PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28444938-0	2017	Low concentration arsenite activated JAK2/STAT3 signal and increased proliferative factor expressions in SV-HUC-1cells after short and long time treatment.	arsenite	18-26	Janus kinase 2	Homo sapiens	37-41
28444938-0	2017	Low concentration arsenite activated JAK2/STAT3 signal and increased proliferative factor expressions in SV-HUC-1cells after short and long time treatment.	arsenite	18-26	signal transducer and activator of transcription 3	Homo sapiens	42-47
28444938-2	2017	This study examined the effects of arsenite on JAK2/STAT3 pathway and expressions of proliferation and anti-apoptosis factors.	arsenite	35-43	Janus kinase 2	Homo sapiens	47-51
28444938-2	2017	This study examined the effects of arsenite on JAK2/STAT3 pathway and expressions of proliferation and anti-apoptosis factors.	arsenite	35-43	signal transducer and activator of transcription 3	Homo sapiens	52-57
28444938-4	2017	mRNA and protein expressions of proliferation factors, such as cyclin D1, COX-2, and proliferating cell nuclear antigen (PCNA), increased in chronically exposed arsenite SV-HUC-1 cells with exposure time.	arsenite	161-169	cyclin D1	Homo sapiens	63-72
28444938-4	2017	mRNA and protein expressions of proliferation factors, such as cyclin D1, COX-2, and proliferating cell nuclear antigen (PCNA), increased in chronically exposed arsenite SV-HUC-1 cells with exposure time.	arsenite	161-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
28444938-4	2017	mRNA and protein expressions of proliferation factors, such as cyclin D1, COX-2, and proliferating cell nuclear antigen (PCNA), increased in chronically exposed arsenite SV-HUC-1 cells with exposure time.	arsenite	161-169	proliferating cell nuclear antigen	Homo sapiens	85-119
28444938-4	2017	mRNA and protein expressions of proliferation factors, such as cyclin D1, COX-2, and proliferating cell nuclear antigen (PCNA), increased in chronically exposed arsenite SV-HUC-1 cells with exposure time.	arsenite	161-169	proliferating cell nuclear antigen	Homo sapiens	121-125
28444938-5	2017	Furthermore, JAK2/STAT3 signal pathway was activated following exposure to arsenite in SV-HUC-1 cells.	arsenite	75-83	Janus kinase 2	Homo sapiens	13-17
28444938-5	2017	Furthermore, JAK2/STAT3 signal pathway was activated following exposure to arsenite in SV-HUC-1 cells.	arsenite	75-83	signal transducer and activator of transcription 3	Homo sapiens	18-23
28444938-6	2017	Knockdown of STAT3 reduced expressions of cyclin D1, COX-2, PCNA, and BCL2 induced by arsenite.	arsenite	86-94	signal transducer and activator of transcription 3	Homo sapiens	13-18
28444938-6	2017	Knockdown of STAT3 reduced expressions of cyclin D1, COX-2, PCNA, and BCL2 induced by arsenite.	arsenite	86-94	cyclin D1	Homo sapiens	42-51
28444938-6	2017	Knockdown of STAT3 reduced expressions of cyclin D1, COX-2, PCNA, and BCL2 induced by arsenite.	arsenite	86-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
28444938-6	2017	Knockdown of STAT3 reduced expressions of cyclin D1, COX-2, PCNA, and BCL2 induced by arsenite.	arsenite	86-94	proliferating cell nuclear antigen	Homo sapiens	60-64
28444938-6	2017	Knockdown of STAT3 reduced expressions of cyclin D1, COX-2, PCNA, and BCL2 induced by arsenite.	arsenite	86-94	BCL2 apoptosis regulator	Homo sapiens	70-74
28444938-7	2017	In conclusion, arsenic induced proliferation in human uroepithelial cells after short and long term exposure to arsenite and JAK2/STAT3 signaling pathway might be pivotal in arsenite-induced proliferation by regulating cyclin D1, COX-2, PCNA, and BCL2.	arsenite	112-120	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
28444938-7	2017	In conclusion, arsenic induced proliferation in human uroepithelial cells after short and long term exposure to arsenite and JAK2/STAT3 signaling pathway might be pivotal in arsenite-induced proliferation by regulating cyclin D1, COX-2, PCNA, and BCL2.	arsenite	112-120	proliferating cell nuclear antigen	Homo sapiens	237-241
28444938-7	2017	In conclusion, arsenic induced proliferation in human uroepithelial cells after short and long term exposure to arsenite and JAK2/STAT3 signaling pathway might be pivotal in arsenite-induced proliferation by regulating cyclin D1, COX-2, PCNA, and BCL2.	arsenite	112-120	BCL2 apoptosis regulator	Homo sapiens	247-251
28444938-7	2017	In conclusion, arsenic induced proliferation in human uroepithelial cells after short and long term exposure to arsenite and JAK2/STAT3 signaling pathway might be pivotal in arsenite-induced proliferation by regulating cyclin D1, COX-2, PCNA, and BCL2.	arsenite	174-182	Janus kinase 2	Homo sapiens	125-129
28444938-7	2017	In conclusion, arsenic induced proliferation in human uroepithelial cells after short and long term exposure to arsenite and JAK2/STAT3 signaling pathway might be pivotal in arsenite-induced proliferation by regulating cyclin D1, COX-2, PCNA, and BCL2.	arsenite	174-182	signal transducer and activator of transcription 3	Homo sapiens	130-135
28444938-7	2017	In conclusion, arsenic induced proliferation in human uroepithelial cells after short and long term exposure to arsenite and JAK2/STAT3 signaling pathway might be pivotal in arsenite-induced proliferation by regulating cyclin D1, COX-2, PCNA, and BCL2.	arsenite	174-182	cyclin D1	Homo sapiens	219-228
28444938-7	2017	In conclusion, arsenic induced proliferation in human uroepithelial cells after short and long term exposure to arsenite and JAK2/STAT3 signaling pathway might be pivotal in arsenite-induced proliferation by regulating cyclin D1, COX-2, PCNA, and BCL2.	arsenite	174-182	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-235
28444938-7	2017	In conclusion, arsenic induced proliferation in human uroepithelial cells after short and long term exposure to arsenite and JAK2/STAT3 signaling pathway might be pivotal in arsenite-induced proliferation by regulating cyclin D1, COX-2, PCNA, and BCL2.	arsenite	174-182	proliferating cell nuclear antigen	Homo sapiens	237-241
28444938-7	2017	In conclusion, arsenic induced proliferation in human uroepithelial cells after short and long term exposure to arsenite and JAK2/STAT3 signaling pathway might be pivotal in arsenite-induced proliferation by regulating cyclin D1, COX-2, PCNA, and BCL2.	arsenite	174-182	BCL2 apoptosis regulator	Homo sapiens	247-251
28351811-5	2017	High arsenite concentrations and As(III)/TDIAs ratios were found in areas having high concentrations of chlorophyll-a, particularly in the subsurface waters of the central SYS during the drifting surveys, where a significant SPB occurred.	arsenite	5-13	surfactant protein B	Homo sapiens	225-228
28549828-0	2017	Deficiency of long isoforms of Nfe2l1 sensitizes MIN6 pancreatic beta cells to arsenite-induced cytotoxicity.	arsenite	79-87	nuclear factor, erythroid derived 2,-like 1	Mus musculus	31-37
28549828-3	2017	We previously showed that nuclear factor erythroid 2 like 2 (Nfe2l2)-deficient pancreatic beta-cells were vulnerable to cell damage induced by oxidative stressors including arsenite, due to a muted antioxidant response.	arsenite	173-181	nuclear factor, erythroid derived 2, like 2	Mus musculus	26-59
28549828-3	2017	We previously showed that nuclear factor erythroid 2 like 2 (Nfe2l2)-deficient pancreatic beta-cells were vulnerable to cell damage induced by oxidative stressors including arsenite, due to a muted antioxidant response.	arsenite	173-181	nuclear factor, erythroid derived 2, like 2	Mus musculus	61-67
28549828-6	2017	In the current study, we demonstrated that MIN6 cells with a specific knockdown of long isoforms of Nfe2l1 (L-Nfe2l1) by lentiviral shRNA (Nfe2l1(L)-KD) were vulnerable to arsenite-induced apoptosis and cell damage.	arsenite	172-180	nuclear factor, erythroid derived 2,-like 1	Mus musculus	100-106
28549828-6	2017	In the current study, we demonstrated that MIN6 cells with a specific knockdown of long isoforms of Nfe2l1 (L-Nfe2l1) by lentiviral shRNA (Nfe2l1(L)-KD) were vulnerable to arsenite-induced apoptosis and cell damage.	arsenite	172-180	nuclear factor, erythroid derived 2,-like 1	Mus musculus	108-116
28549828-6	2017	In the current study, we demonstrated that MIN6 cells with a specific knockdown of long isoforms of Nfe2l1 (L-Nfe2l1) by lentiviral shRNA (Nfe2l1(L)-KD) were vulnerable to arsenite-induced apoptosis and cell damage.	arsenite	172-180	nuclear factor, erythroid derived 2,-like 1	Mus musculus	110-116
28549828-10	2017	These results showed that deficiency of L-Nfe2l1 in pancreatic beta-cells increased susceptibility to acute arsenite-induced cytotoxicity by promoting arsenic biotransformation and intracellular MMA levels.	arsenite	108-116	nuclear factor, erythroid derived 2,-like 1	Mus musculus	40-48
28688901-0	2017	MicroRNA-155 regulates arsenite-induced malignant transformation by targeting Nrf2-mediated oxidative damage in human bronchial epithelial cells.	arsenite	23-31	NFE2 like bZIP transcription factor 2	Homo sapiens	78-82
28688901-7	2017	Together, our findings provide the novel mechanism that miR-155 may regulate arsenite-induced cell malignant transformation by targeting Nrf2-mediated oxidative damage, indicating that inhibition of miR-155 may be a potential strategy against lung carcinogenesis of arsenite.	arsenite	77-85	microRNA 155	Homo sapiens	56-63
28688901-7	2017	Together, our findings provide the novel mechanism that miR-155 may regulate arsenite-induced cell malignant transformation by targeting Nrf2-mediated oxidative damage, indicating that inhibition of miR-155 may be a potential strategy against lung carcinogenesis of arsenite.	arsenite	77-85	NFE2 like bZIP transcription factor 2	Homo sapiens	137-141
28688901-7	2017	Together, our findings provide the novel mechanism that miR-155 may regulate arsenite-induced cell malignant transformation by targeting Nrf2-mediated oxidative damage, indicating that inhibition of miR-155 may be a potential strategy against lung carcinogenesis of arsenite.	arsenite	77-85	microRNA 155	Homo sapiens	199-206
28688901-7	2017	Together, our findings provide the novel mechanism that miR-155 may regulate arsenite-induced cell malignant transformation by targeting Nrf2-mediated oxidative damage, indicating that inhibition of miR-155 may be a potential strategy against lung carcinogenesis of arsenite.	arsenite	266-274	microRNA 155	Homo sapiens	56-63
28688901-7	2017	Together, our findings provide the novel mechanism that miR-155 may regulate arsenite-induced cell malignant transformation by targeting Nrf2-mediated oxidative damage, indicating that inhibition of miR-155 may be a potential strategy against lung carcinogenesis of arsenite.	arsenite	266-274	NFE2 like bZIP transcription factor 2	Homo sapiens	137-141
28688901-7	2017	Together, our findings provide the novel mechanism that miR-155 may regulate arsenite-induced cell malignant transformation by targeting Nrf2-mediated oxidative damage, indicating that inhibition of miR-155 may be a potential strategy against lung carcinogenesis of arsenite.	arsenite	266-274	microRNA 155	Homo sapiens	199-206
28785074-7	2017	In addition, treatment of PD98059 reversed low-dose arsenite-induced MDM2 expression, and the inhibition of ERK2 expression could significantly block MDM2 expression as a consequence, and p53 expression automatically was increased.	arsenite	52-60	MDM2 proto-oncogene	Homo sapiens	69-73
28785074-0	2017	Low dose arsenite confers resistance to UV induced apoptosis via p53-MDM2 pathway in ketatinocytes.	arsenite	9-17	tumor protein p53	Homo sapiens	65-68
28785074-0	2017	Low dose arsenite confers resistance to UV induced apoptosis via p53-MDM2 pathway in ketatinocytes.	arsenite	9-17	MDM2 proto-oncogene	Homo sapiens	69-73
28785074-4	2017	We found that the cell apoptosis induced by UV exposure was significantly attenuated after exposure to low-dose arsenite, and knockdown of p53 could block UV-induced apoptosis indicating that this phenomenon depended on p53.	arsenite	112-120	tumor protein p53	Homo sapiens	139-142
28785074-4	2017	We found that the cell apoptosis induced by UV exposure was significantly attenuated after exposure to low-dose arsenite, and knockdown of p53 could block UV-induced apoptosis indicating that this phenomenon depended on p53.	arsenite	112-120	tumor protein p53	Homo sapiens	220-223
28785074-5	2017	Interestingly, the expression of murine double minute 2 (MDM2), including its protein and transcriptional levels, was remarkably high after exposure to low-dose arsenite.	arsenite	161-169	transformed mouse 3T3 cell double minute 2	Mus musculus	33-55
28785074-5	2017	Interestingly, the expression of murine double minute 2 (MDM2), including its protein and transcriptional levels, was remarkably high after exposure to low-dose arsenite.	arsenite	161-169	transformed mouse 3T3 cell double minute 2	Mus musculus	57-61
28785074-6	2017	Moreover, low-dose arsenite treatment dramatically decreased the MDM2 gene promoter activity, suggesting that this effect has been mediated through transcription.	arsenite	19-27	MDM2 proto-oncogene	Homo sapiens	65-69
28739695-8	2017	Increased radiosensitivity by arsenite was also abolished following knock-down of BRCA2.	arsenite	30-38	BRCA2 DNA repair associated	Homo sapiens	82-87
28739695-9	2017	In addition, the increased radiosensitization by arsenite was correlated with AAC, which was abolished by BRCA2 knock-down.	arsenite	49-57	BRCA2 DNA repair associated	Homo sapiens	106-111
28739695-10	2017	CONCLUSION: We conclude that radiosensitization by arsenite is related to ROS and BRCA2 function.	arsenite	51-59	BRCA2 DNA repair associated	Homo sapiens	82-87
28785074-7	2017	In addition, treatment of PD98059 reversed low-dose arsenite-induced MDM2 expression, and the inhibition of ERK2 expression could significantly block MDM2 expression as a consequence, and p53 expression automatically was increased.	arsenite	52-60	tumor protein p53	Homo sapiens	188-191
28785074-9	2017	Taken together, our results demonstrated that low-dose arsenite-induced resistance to apoptosis through p53 mediated by MDM2 in keratinocytes.	arsenite	55-63	tumor protein p53	Homo sapiens	104-107
28785074-9	2017	Taken together, our results demonstrated that low-dose arsenite-induced resistance to apoptosis through p53 mediated by MDM2 in keratinocytes.	arsenite	55-63	MDM2 proto-oncogene	Homo sapiens	120-124
27774770-0	2017	Protection of Nrf2 against arsenite-induced oxidative damage is regulated by the cyclic guanosine monophosphate-protein kinase G signaling pathway.	arsenite	27-35	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
27774770-3	2017	We previously showed that the level of Nrf2, a nuclear transcription factor significantly increased in arsenite-treated human bronchial epithelial (HBE) cells suggesting that Nrf2 is involved in responding to arsenite-induced oxidative damage.	arsenite	103-111	NFE2 like bZIP transcription factor 2	Homo sapiens	39-43
27774770-3	2017	We previously showed that the level of Nrf2, a nuclear transcription factor significantly increased in arsenite-treated human bronchial epithelial (HBE) cells suggesting that Nrf2 is involved in responding to arsenite-induced oxidative damage.	arsenite	103-111	NFE2 like bZIP transcription factor 2	Homo sapiens	175-179
27774770-3	2017	We previously showed that the level of Nrf2, a nuclear transcription factor significantly increased in arsenite-treated human bronchial epithelial (HBE) cells suggesting that Nrf2 is involved in responding to arsenite-induced oxidative damage.	arsenite	209-217	NFE2 like bZIP transcription factor 2	Homo sapiens	39-43
27774770-3	2017	We previously showed that the level of Nrf2, a nuclear transcription factor significantly increased in arsenite-treated human bronchial epithelial (HBE) cells suggesting that Nrf2 is involved in responding to arsenite-induced oxidative damage.	arsenite	209-217	NFE2 like bZIP transcription factor 2	Homo sapiens	175-179
27774770-4	2017	To explore how Nrf2 can impact arsenite-induced oxidative damage, in this study, we examined Nrf2 activation and its regulation upon cellular arsenite exposure as well as its effects on arsenite-induced oxidative damage in HBE cells.	arsenite	31-39	NFE2 like bZIP transcription factor 2	Homo sapiens	15-19
27774770-4	2017	To explore how Nrf2 can impact arsenite-induced oxidative damage, in this study, we examined Nrf2 activation and its regulation upon cellular arsenite exposure as well as its effects on arsenite-induced oxidative damage in HBE cells.	arsenite	142-150	NFE2 like bZIP transcription factor 2	Homo sapiens	15-19
27774770-4	2017	To explore how Nrf2 can impact arsenite-induced oxidative damage, in this study, we examined Nrf2 activation and its regulation upon cellular arsenite exposure as well as its effects on arsenite-induced oxidative damage in HBE cells.	arsenite	142-150	NFE2 like bZIP transcription factor 2	Homo sapiens	93-97
27774770-4	2017	To explore how Nrf2 can impact arsenite-induced oxidative damage, in this study, we examined Nrf2 activation and its regulation upon cellular arsenite exposure as well as its effects on arsenite-induced oxidative damage in HBE cells.	arsenite	142-150	NFE2 like bZIP transcription factor 2	Homo sapiens	15-19
27774770-4	2017	To explore how Nrf2 can impact arsenite-induced oxidative damage, in this study, we examined Nrf2 activation and its regulation upon cellular arsenite exposure as well as its effects on arsenite-induced oxidative damage in HBE cells.	arsenite	142-150	NFE2 like bZIP transcription factor 2	Homo sapiens	93-97
27774770-5	2017	We found that Nrf2 mRNA and protein levels were significantly increased by arsenite in a dose- and time-dependent manner.	arsenite	75-83	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
27774770-6	2017	Furthermore, we showed that over-expression of Nrf2 significantly reduced the level of arsenite-induced oxidative damage in HBE cells including DNA damage, chromosomal breakage, lipid peroxidation and depletion of antioxidants.	arsenite	87-95	NFE2 like bZIP transcription factor 2	Homo sapiens	47-51
28709527-12	2017	The predicted optimal conditions for the maximum removal efficiency were achieved with initial arsenite concentration, 0.68mgL-1; C-nZVI, 0.3 (gL-1); time, 31.25 (min) and pH, 5.2.	arsenite	95-103	LLGL scribble cell polarity complex component 1	Homo sapiens	123-128
28502835-0	2017	The ADMA/DDAH/NO pathway in human vein endothelial cells exposed to arsenite.	arsenite	68-76	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	4-16
28502835-6	2017	We aimed to determine the ADMA/DDAH/NO pathway in human vein endothelial cells (HUVEC-CS) exposed to arsenite.	arsenite	101-109	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	31-35
28502835-9	2017	We also found a decrease in DDAH-1 protein expression with 5muM of arsenite compared to the control group.	arsenite	67-75	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	28-34
28502835-11	2017	Finally, arsenite (2.5 and 5muM) increased NADPH oxidase 4 protein levels compared with the control group.	arsenite	9-17	NADPH oxidase 4	Homo sapiens	43-58
28502835-12	2017	We conclude that ADMA, l-arginine and DDAH are involved in NO depletion produced by arsenite, and that the mechanism is related to oxidative stress.	arsenite	84-92	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	38-42
28746877-3	2017	In contrast to arsenite treatment, where dephosphorylated Ser142 Rasputin is recruited to stress granules, we find that, upon amino acid starvation, only the phosphorylated Ser142 form is recruited.	arsenite	15-23	rasputin	Drosophila melanogaster	65-73
28535027-0	2017	Arsenite Binds to the RING Finger Domain of FANCL E3 Ubiquitin Ligase and Inhibits DNA Interstrand Crosslink Repair.	arsenite	0-8	FA complementation group L	Homo sapiens	44-49
28715409-6	2017	We demonstrate that ZIKV negatively impacts SG assembly under oxidative stress conditions induced by sodium arsenite (Ars), a treatment that leads to the phosphorylation of eIF2alpha.	arsenite	118-121	eukaryotic translation initiation factor 2A	Homo sapiens	173-182
28769902-3	2017	The arxA gene, encoding anaerobic arsenite oxidase, was successfully amplified from the genome of strain TC-1, indicating it has a potential ability to oxidize arsenite under anaerobic condition.	arsenite	34-42	transcobalamin 1	Homo sapiens	105-109
28769902-4	2017	In anaerobic arsenite oxidation experiments inoculated with strain TC-1, a small amount of arsenate was detected in the beginning but became undetectable over longer time.	arsenite	13-21	transcobalamin 1	Homo sapiens	67-71
28382961-4	2017	The analysis of their catalytic properties clearly demonstrates that C. reinhardtii ArsA proteins exhibit oxyanion-independent ATPase activity, as neither arsenite nor antimonite showed strong effects.	arsenite	155-163	arylsulfatase A	Homo sapiens	84-88
28419250-0	2017	Enhanced glycolysis, regulated by HIF-1alpha via MCT-4, promotes inflammation in arsenite-induced carcinogenesis.	arsenite	81-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-44
28419250-0	2017	Enhanced glycolysis, regulated by HIF-1alpha via MCT-4, promotes inflammation in arsenite-induced carcinogenesis.	arsenite	81-89	solute carrier family 16 member 3	Homo sapiens	49-54
28419250-5	2017	In liver cells exposed to arsenite, hypoxia inducible factor-1alpha (HIF-1alpha) and monocarboxylate transporter-4 (MCT-4) are over-expressed.	arsenite	26-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-67
28419250-5	2017	In liver cells exposed to arsenite, hypoxia inducible factor-1alpha (HIF-1alpha) and monocarboxylate transporter-4 (MCT-4) are over-expressed.	arsenite	26-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-79
28419250-5	2017	In liver cells exposed to arsenite, hypoxia inducible factor-1alpha (HIF-1alpha) and monocarboxylate transporter-4 (MCT-4) are over-expressed.	arsenite	26-34	solute carrier family 16 member 3	Homo sapiens	85-114
28419250-5	2017	In liver cells exposed to arsenite, hypoxia inducible factor-1alpha (HIF-1alpha) and monocarboxylate transporter-4 (MCT-4) are over-expressed.	arsenite	26-34	solute carrier family 16 member 3	Homo sapiens	116-121
28419250-9	2017	In sum, these findings indicate that MCT-4, mediated by HIF-1alpha, enhances the glycolysis induced by arsenite.	arsenite	103-111	solute carrier family 16 member 3	Homo sapiens	37-42
28419250-9	2017	In sum, these findings indicate that MCT-4, mediated by HIF-1alpha, enhances the glycolysis induced by arsenite.	arsenite	103-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-66
28359760-0	2017	Effect of p62/SQSTM1 polyubiquitination on its autophagic adaptor function and cellular survival under oxidative stress induced by arsenite.	arsenite	131-139	sequestosome 1	Homo sapiens	10-13
28359760-0	2017	Effect of p62/SQSTM1 polyubiquitination on its autophagic adaptor function and cellular survival under oxidative stress induced by arsenite.	arsenite	131-139	sequestosome 1	Homo sapiens	14-20
28140569-6	2017	Ingenuity pathway analysis revealed the arsenite-induced alteration of more than 10 biological pathways, including the Nrf2-mediated oxidative stress response pathway, which is represented by the upregulation of nine proteins in this pathway.	arsenite	40-48	NFE2 like bZIP transcription factor 2	Homo sapiens	119-123
27774770-7	2017	This indicates a protective role of Nrf2 against arsenite toxicity.	arsenite	49-57	NFE2 like bZIP transcription factor 2	Homo sapiens	36-40
27774770-8	2017	This was further supported by the fact that activation of Nrf2 by its agonists, tertiary butylhydroquinone (t-BHQ) and sulforaphane (SFN) resulted in the same protective effects against arsenite toxicity.	arsenite	186-194	NFE2 like bZIP transcription factor 2	Homo sapiens	58-62
27774770-9	2017	Moreover, we demonstrated that arsenite-induced activation of Nrf2 was mediated by the cyclic guanosine monophosphate (cGMP)-protein kinase G (PKG) signaling pathway.	arsenite	31-39	NFE2 like bZIP transcription factor 2	Homo sapiens	62-66
27774770-9	2017	Moreover, we demonstrated that arsenite-induced activation of Nrf2 was mediated by the cyclic guanosine monophosphate (cGMP)-protein kinase G (PKG) signaling pathway.	arsenite	31-39	protein kinase cGMP-dependent 1	Homo sapiens	143-146
27774770-10	2017	This is the first evidence showing that Nrf2 protects against arsenite-induced oxidative damage through the cGMP-PKG pathway.	arsenite	62-70	NFE2 like bZIP transcription factor 2	Homo sapiens	40-44
27774770-10	2017	This is the first evidence showing that Nrf2 protects against arsenite-induced oxidative damage through the cGMP-PKG pathway.	arsenite	62-70	protein kinase cGMP-dependent 1	Homo sapiens	113-116
27774770-11	2017	Our study suggests that activation of Nrf2 through the cGMP-PKG signaling pathway in HBE cells may be developed as a new strategy for prevention of arsenite toxicity.	arsenite	148-156	NFE2 like bZIP transcription factor 2	Homo sapiens	38-42
27774770-11	2017	Our study suggests that activation of Nrf2 through the cGMP-PKG signaling pathway in HBE cells may be developed as a new strategy for prevention of arsenite toxicity.	arsenite	148-156	protein kinase cGMP-dependent 1	Homo sapiens	60-63
30505209-2	2017	Pilot scale experiments were performed in a distribution system simulator by injecting arsenic and measuring both adsorption onto iron pipe material and the oxidation of arsenite by hypochlorite in tap water to form arsenate.	arsenite	170-178	nuclear RNA export factor 1	Homo sapiens	198-201
27993642-9	2017	However, caspase-3 cleavage and Bax/Bcl-2 ratio were notably greater in 100nM, and lesser in 5nM arsenite group in comparison with control animals.	arsenite	97-105	caspase 3	Rattus norvegicus	9-18
28296918-0	2017	Calcium-dependent protein kinase CPK31 interacts with arsenic transporter AtNIP1;1 and regulates arsenite uptake in Arabidopsis thaliana.	arsenite	97-105	calcium-dependent protein kinase 31	Arabidopsis thaliana	33-38
28062277-0	2017	Circ100284, via miR-217 regulation of EZH2, is involved in the arsenite-accelerated cell cycle of human keratinocytes in carcinogenesis.	arsenite	63-71	microRNA 217	Homo sapiens	16-23
28062277-0	2017	Circ100284, via miR-217 regulation of EZH2, is involved in the arsenite-accelerated cell cycle of human keratinocytes in carcinogenesis.	arsenite	63-71	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	38-42
28062277-6	2017	In these cells, arsenite induced increases of EZH2 and cyclin D1 and accelerated the cell cycle.	arsenite	16-24	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	46-50
28062277-6	2017	In these cells, arsenite induced increases of EZH2 and cyclin D1 and accelerated the cell cycle.	arsenite	16-24	cyclin D1	Homo sapiens	55-64
28062277-8	2017	Further, in HaCaT cells exposed to arsenite, EZH2 regulated the cell cycle by binding to the promoter of CCND1, which codes for cyclin D1.	arsenite	35-43	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	45-49
28062277-8	2017	Further, in HaCaT cells exposed to arsenite, EZH2 regulated the cell cycle by binding to the promoter of CCND1, which codes for cyclin D1.	arsenite	35-43	cyclin D1	Homo sapiens	105-110
28062277-8	2017	Further, in HaCaT cells exposed to arsenite, EZH2 regulated the cell cycle by binding to the promoter of CCND1, which codes for cyclin D1.	arsenite	35-43	cyclin D1	Homo sapiens	128-137
28062277-9	2017	Moreover, knockdown of circ100284 with siRNA inhibited the cell cycle acceleration induced by arsenite, but this inhibition was reversed by co-transfection with circ100284 siRNA and by a miR-217 inhibitor.	arsenite	94-102	microRNA 217	Homo sapiens	187-194
28062277-11	2017	These results suggest that, in HaCaT cells, arsenite increases circ100284 levels, which act as a sponge for miR-217 and up-regulate the miR-217 target, EZH2, which, in turn, up-regulates cyclin D1and CDK4, and thus accelerates the cell cycle and leads to malignant transformation.	arsenite	44-52	microRNA 217	Homo sapiens	108-115
28062277-11	2017	These results suggest that, in HaCaT cells, arsenite increases circ100284 levels, which act as a sponge for miR-217 and up-regulate the miR-217 target, EZH2, which, in turn, up-regulates cyclin D1and CDK4, and thus accelerates the cell cycle and leads to malignant transformation.	arsenite	44-52	microRNA 217	Homo sapiens	136-143
28062277-11	2017	These results suggest that, in HaCaT cells, arsenite increases circ100284 levels, which act as a sponge for miR-217 and up-regulate the miR-217 target, EZH2, which, in turn, up-regulates cyclin D1and CDK4, and thus accelerates the cell cycle and leads to malignant transformation.	arsenite	44-52	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	152-156
28062277-11	2017	These results suggest that, in HaCaT cells, arsenite increases circ100284 levels, which act as a sponge for miR-217 and up-regulate the miR-217 target, EZH2, which, in turn, up-regulates cyclin D1and CDK4, and thus accelerates the cell cycle and leads to malignant transformation.	arsenite	44-52	cyclin D1	Homo sapiens	187-196
28062277-11	2017	These results suggest that, in HaCaT cells, arsenite increases circ100284 levels, which act as a sponge for miR-217 and up-regulate the miR-217 target, EZH2, which, in turn, up-regulates cyclin D1and CDK4, and thus accelerates the cell cycle and leads to malignant transformation.	arsenite	44-52	cyclin dependent kinase 4	Homo sapiens	200-204
28062277-12	2017	Thus, circ100284, via miR-217 regulation of EZH2, is involved in the arsenite-accelerated cell cycle of human keratinocytes in carcinogenesis.	arsenite	69-77	microRNA 217	Homo sapiens	22-29
28062277-12	2017	Thus, circ100284, via miR-217 regulation of EZH2, is involved in the arsenite-accelerated cell cycle of human keratinocytes in carcinogenesis.	arsenite	69-77	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	44-48
27913196-5	2017	The results show that the exosomes from arsenite-transformed L-02 cells enhance miR-155 expression and the pro-inflammatory properties of normal L-02 and THLE-3 cells.	arsenite	40-48	microRNA 155	Homo sapiens	80-87
27913196-10	2017	In addition, miR-155, IL-6, and IL-8 were over-expressed in the serum of arsenite exposure group.	arsenite	73-81	microRNA 155	Homo sapiens	13-20
27913196-10	2017	In addition, miR-155, IL-6, and IL-8 were over-expressed in the serum of arsenite exposure group.	arsenite	73-81	interleukin 6	Homo sapiens	22-26
27913196-10	2017	In addition, miR-155, IL-6, and IL-8 were over-expressed in the serum of arsenite exposure group.	arsenite	73-81	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
27913196-12	2017	Further, exosomal miR-155 was up-regulated in the serum of arsenite exposure group.	arsenite	59-67	microRNA 155	Homo sapiens	18-25
28237703-1	2017	The polyubiquitin genes Ubb and Ubc are upregulated under oxidative stress induced by arsenite [As(III)].	arsenite	86-94	ubiquitin B	Mus musculus	24-27
28237703-1	2017	The polyubiquitin genes Ubb and Ubc are upregulated under oxidative stress induced by arsenite [As(III)].	arsenite	86-94	ubiquitin C	Mus musculus	32-35
28237621-8	2017	Treatment of both cell types with arsenite resulted in a significant reduction in the abundance of XPC, a protein that is critical for DNA damage recognition in NER.	arsenite	34-42	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	99-102
28238834-9	2017	ROR-alpha seems also to play role in cellular sensitivity to environmental substances like arsenite and chloroprene.	arsenite	91-99	RAR related orphan receptor A	Homo sapiens	0-9
30090515-0	2017	ATF2 partly mediated the expressions of proliferative factors and inhibited pro-inflammatory factors" secretion in arsenite-treated human uroepithelial cells.	arsenite	115-123	activating transcription factor 2	Homo sapiens	0-4
30090515-5	2017	The results showed that low concentration arsenite increased the expressions of proliferative factors BCL2, cyclin D1, COX-2, MMP1 and PCNA in SV-HUC-1 cells, and ATF2 siRNA partly decreased the expressions of BCL2, cyclin D1, and COX-2.	arsenite	42-50	BCL2 apoptosis regulator	Homo sapiens	102-106
30090515-5	2017	The results showed that low concentration arsenite increased the expressions of proliferative factors BCL2, cyclin D1, COX-2, MMP1 and PCNA in SV-HUC-1 cells, and ATF2 siRNA partly decreased the expressions of BCL2, cyclin D1, and COX-2.	arsenite	42-50	cyclin D1	Homo sapiens	108-117
30090515-5	2017	The results showed that low concentration arsenite increased the expressions of proliferative factors BCL2, cyclin D1, COX-2, MMP1 and PCNA in SV-HUC-1 cells, and ATF2 siRNA partly decreased the expressions of BCL2, cyclin D1, and COX-2.	arsenite	42-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
30090515-5	2017	The results showed that low concentration arsenite increased the expressions of proliferative factors BCL2, cyclin D1, COX-2, MMP1 and PCNA in SV-HUC-1 cells, and ATF2 siRNA partly decreased the expressions of BCL2, cyclin D1, and COX-2.	arsenite	42-50	matrix metallopeptidase 1	Homo sapiens	126-130
30090515-5	2017	The results showed that low concentration arsenite increased the expressions of proliferative factors BCL2, cyclin D1, COX-2, MMP1 and PCNA in SV-HUC-1 cells, and ATF2 siRNA partly decreased the expressions of BCL2, cyclin D1, and COX-2.	arsenite	42-50	proliferating cell nuclear antigen	Homo sapiens	135-139
30090515-5	2017	The results showed that low concentration arsenite increased the expressions of proliferative factors BCL2, cyclin D1, COX-2, MMP1 and PCNA in SV-HUC-1 cells, and ATF2 siRNA partly decreased the expressions of BCL2, cyclin D1, and COX-2.	arsenite	42-50	activating transcription factor 2	Homo sapiens	163-167
30090515-5	2017	The results showed that low concentration arsenite increased the expressions of proliferative factors BCL2, cyclin D1, COX-2, MMP1 and PCNA in SV-HUC-1 cells, and ATF2 siRNA partly decreased the expressions of BCL2, cyclin D1, and COX-2.	arsenite	42-50	BCL2 apoptosis regulator	Homo sapiens	210-214
30090515-5	2017	The results showed that low concentration arsenite increased the expressions of proliferative factors BCL2, cyclin D1, COX-2, MMP1 and PCNA in SV-HUC-1 cells, and ATF2 siRNA partly decreased the expressions of BCL2, cyclin D1, and COX-2.	arsenite	42-50	cyclin D1	Homo sapiens	216-225
30090515-5	2017	The results showed that low concentration arsenite increased the expressions of proliferative factors BCL2, cyclin D1, COX-2, MMP1 and PCNA in SV-HUC-1 cells, and ATF2 siRNA partly decreased the expressions of BCL2, cyclin D1, and COX-2.	arsenite	42-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	231-236
30090515-7	2017	In addition, ATF2 knockdown did not decrease the expressions of pro-inflammatory cytokines induced by arsenite in SV-HUC-1 cells, but dramatically increased mRNA expressions of TNFalpha, TGFalpha and IL-8 under arsenite and non-arsenite conditions.	arsenite	211-219	activating transcription factor 2	Homo sapiens	13-17
30090515-7	2017	In addition, ATF2 knockdown did not decrease the expressions of pro-inflammatory cytokines induced by arsenite in SV-HUC-1 cells, but dramatically increased mRNA expressions of TNFalpha, TGFalpha and IL-8 under arsenite and non-arsenite conditions.	arsenite	211-219	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
30090515-7	2017	In addition, ATF2 knockdown did not decrease the expressions of pro-inflammatory cytokines induced by arsenite in SV-HUC-1 cells, but dramatically increased mRNA expressions of TNFalpha, TGFalpha and IL-8 under arsenite and non-arsenite conditions.	arsenite	211-219	activating transcription factor 2	Homo sapiens	13-17
30090515-7	2017	In addition, ATF2 knockdown did not decrease the expressions of pro-inflammatory cytokines induced by arsenite in SV-HUC-1 cells, but dramatically increased mRNA expressions of TNFalpha, TGFalpha and IL-8 under arsenite and non-arsenite conditions.	arsenite	211-219	C-X-C motif chemokine ligand 8	Homo sapiens	200-204
30090515-8	2017	In conclusion, our present study indicated that ATF2, but not IL-8, played a partial role in the expressions of proliferative factors induced by arsenite in human uroepithelial cells.	arsenite	145-153	activating transcription factor 2	Homo sapiens	48-52
28011284-4	2017	In this study, we demonstrated that the Tudor-SN protein was phosphorylated at threonine 103 (T103) upon stimulation with arsenite.	arsenite	122-130	staphylococcal nuclease and tudor domain containing 1	Homo sapiens	40-48
27993642-9	2017	However, caspase-3 cleavage and Bax/Bcl-2 ratio were notably greater in 100nM, and lesser in 5nM arsenite group in comparison with control animals.	arsenite	97-105	BCL2 associated X, apoptosis regulator	Rattus norvegicus	32-35
27993642-9	2017	However, caspase-3 cleavage and Bax/Bcl-2 ratio were notably greater in 100nM, and lesser in 5nM arsenite group in comparison with control animals.	arsenite	97-105	BCL2, apoptosis regulator	Rattus norvegicus	36-41
27810535-7	2017	X-ray absorption near-edge spectroscopy (XANES) analysis showed that 44.2-97.6% of arsenite [As(III)] generated due to arsenate [As(V)] reduction was in the soil solid phase after the colon phase.	arsenite	83-91	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	129-134
28068585-0	2017	Effects of phosphate binders on the gastrointestinal absorption of arsenate and of an SGLT2 inhibitor drug on the urinary excretion of arsenite in mice.	arsenite	135-143	solute carrier family 5 (sodium/glucose cotransporter), member 2	Mus musculus	86-91
28025110-7	2017	In vitro experiments confirmed that arsenite treatment at short-term high doses (10-100muM) and long-term low doses (0.5-1muM) in human lymphoblasts (RPMI 1788) caused promoter hypomethylation of these genes, which was in concordance with an increase in their mRNA expression.	arsenite	36-44	latexin	Homo sapiens	87-90
28125064-0	2017	Phenylarsine Oxide Can Induce the Arsenite-Resistance Mutant PML Protein Solubility Changes.	arsenite	34-42	PML nuclear body scaffold	Homo sapiens	61-64
27856639-7	2017	Interestingly, hYVH1-positive stress granules were significantly smaller, whereas knocking down hYVH1 expression attenuated stress granule breakdown during recovery from arsenite stress, indicating a possible role for hYVH1 in stress granule disassembly.	arsenite	170-178	dual specificity phosphatase 12	Homo sapiens	96-101
27856639-7	2017	Interestingly, hYVH1-positive stress granules were significantly smaller, whereas knocking down hYVH1 expression attenuated stress granule breakdown during recovery from arsenite stress, indicating a possible role for hYVH1 in stress granule disassembly.	arsenite	170-178	dual specificity phosphatase 12	Homo sapiens	96-101
26677073-7	2017	Together, we demonstrated for the first time that arsenite disturbed the Ca2+ homeostasis in ER, which subsequently led to ER stress, mitochondrial dysfunction, and NF-kappaB nuclear translocation, and thus consequently triggering cell apoptosis.	arsenite	50-58	nuclear factor kappa B subunit 1	Homo sapiens	165-174
26306706-0	2016	Nuclear translocation of nuclear factor kappa B is regulated by G protein signaling pathway in arsenite-induced apoptosis in HBE cell line.	arsenite	95-103	nuclear factor kappa B subunit 1	Homo sapiens	25-47
27741521-0	2016	S-nitrosation on zinc finger motif of PARP-1 as a mechanism of DNA repair inhibition by arsenite.	arsenite	88-96	poly(ADP-ribose) polymerase 1	Homo sapiens	38-44
27741521-2	2016	Our recent work suggests that reactive oxygen/nitrogen species (ROS/RNS) induced by arsenite (AsIII) play an important role in the inhibition of the DNA repair protein Poly(ADP-ribose) polymerase 1 (PARP-1).	arsenite	84-92	poly(ADP-ribose) polymerase 1	Homo sapiens	168-197
27741521-2	2016	Our recent work suggests that reactive oxygen/nitrogen species (ROS/RNS) induced by arsenite (AsIII) play an important role in the inhibition of the DNA repair protein Poly(ADP-ribose) polymerase 1 (PARP-1).	arsenite	84-92	poly(ADP-ribose) polymerase 1	Homo sapiens	199-205
27278863-3	2017	Here, we show that oxidative stress, induced by stimulation of the cells with the oxidant arsenite, strongly activated gene transcription via the stress-responsive element (StRE), while phorbol ester or tunicamycin, activators of AP-1/c-Jun or ATF4, respectively, activated AP-1 or nutrient-sensing response element-mediated transcription.	arsenite	90-98	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	230-234
27278863-3	2017	Here, we show that oxidative stress, induced by stimulation of the cells with the oxidant arsenite, strongly activated gene transcription via the stress-responsive element (StRE), while phorbol ester or tunicamycin, activators of AP-1/c-Jun or ATF4, respectively, activated AP-1 or nutrient-sensing response element-mediated transcription.	arsenite	90-98	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	235-240
27278863-3	2017	Here, we show that oxidative stress, induced by stimulation of the cells with the oxidant arsenite, strongly activated gene transcription via the stress-responsive element (StRE), while phorbol ester or tunicamycin, activators of AP-1/c-Jun or ATF4, respectively, activated AP-1 or nutrient-sensing response element-mediated transcription.	arsenite	90-98	activating transcription factor 4	Homo sapiens	244-248
27278863-3	2017	Here, we show that oxidative stress, induced by stimulation of the cells with the oxidant arsenite, strongly activated gene transcription via the stress-responsive element (StRE), while phorbol ester or tunicamycin, activators of AP-1/c-Jun or ATF4, respectively, activated AP-1 or nutrient-sensing response element-mediated transcription.	arsenite	90-98	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	274-278
27278863-4	2017	Preincubation of the cells with N-acetyl-cysteine or overexpression of thioredoxin selectively attenuated arsenite-induced upregulation of StRE-regulated transcription.	arsenite	106-114	thioredoxin	Homo sapiens	71-82
26306706-3	2016	In this study, using human bronchial epithelial cell as a culture system, we demonstrated that arsenite-induced nuclear translocation of nuclear factor kappa B (NF-kappaB) resulted in the release of cytochrome c, the modulation of Fas and FasL, caspase activation, and ultimately leading to cell apoptosis.	arsenite	95-103	nuclear factor kappa B subunit 1	Homo sapiens	137-159
26306706-3	2016	In this study, using human bronchial epithelial cell as a culture system, we demonstrated that arsenite-induced nuclear translocation of nuclear factor kappa B (NF-kappaB) resulted in the release of cytochrome c, the modulation of Fas and FasL, caspase activation, and ultimately leading to cell apoptosis.	arsenite	95-103	nuclear factor kappa B subunit 1	Homo sapiens	161-170
26306706-3	2016	In this study, using human bronchial epithelial cell as a culture system, we demonstrated that arsenite-induced nuclear translocation of nuclear factor kappa B (NF-kappaB) resulted in the release of cytochrome c, the modulation of Fas and FasL, caspase activation, and ultimately leading to cell apoptosis.	arsenite	95-103	cytochrome c, somatic	Homo sapiens	199-211
26306706-3	2016	In this study, using human bronchial epithelial cell as a culture system, we demonstrated that arsenite-induced nuclear translocation of nuclear factor kappa B (NF-kappaB) resulted in the release of cytochrome c, the modulation of Fas and FasL, caspase activation, and ultimately leading to cell apoptosis.	arsenite	95-103	Fas ligand	Homo sapiens	239-243
26306706-4	2016	Importantly, we showed for the first time that the NF-kappaB-mediated apoptosis induced by arsenite was regulated by G protein-adenylate cyclase (AC)-cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) pathway.	arsenite	91-99	nuclear factor kappa B subunit 1	Homo sapiens	51-60
26306706-6	2016	Taken together, our results indicate that arsenite is able to trigger cell apoptosis in human bronchial epithelial cells through the nuclear translocation of NF-kappaB, which can be modulated by G protein signaling pathway.	arsenite	42-50	nuclear factor kappa B subunit 1	Homo sapiens	158-167
27526673-0	2016	TRIB3 increases cell resistance to arsenite toxicity by limiting the expression of the glutathione-degrading enzyme CHAC1.	arsenite	35-43	tribbles pseudokinase 3	Mus musculus	0-5
27526673-0	2016	TRIB3 increases cell resistance to arsenite toxicity by limiting the expression of the glutathione-degrading enzyme CHAC1.	arsenite	35-43	ChaC, cation transport regulator 1	Mus musculus	116-121
27526673-3	2016	In this article, we investigate the role of Tribbles homolog 3 (TRIB3), a regulatory member of the ATF4 pathway, in determining cell sensitivity to arsenite.	arsenite	148-156	tribbles pseudokinase 3	Mus musculus	44-62
27526673-3	2016	In this article, we investigate the role of Tribbles homolog 3 (TRIB3), a regulatory member of the ATF4 pathway, in determining cell sensitivity to arsenite.	arsenite	148-156	tribbles pseudokinase 3	Mus musculus	64-69
27526673-3	2016	In this article, we investigate the role of Tribbles homolog 3 (TRIB3), a regulatory member of the ATF4 pathway, in determining cell sensitivity to arsenite.	arsenite	148-156	activating transcription factor 4	Mus musculus	99-103
27526673-4	2016	Our results show that arsenite potently upregulates Trib3 mRNA and protein in an ATF4-dependent manner in mouse embryonic fibroblasts.	arsenite	22-30	tribbles pseudokinase 3	Mus musculus	52-57
27526673-4	2016	Our results show that arsenite potently upregulates Trib3 mRNA and protein in an ATF4-dependent manner in mouse embryonic fibroblasts.	arsenite	22-30	activating transcription factor 4	Mus musculus	81-85
27526673-5	2016	Trib3-deficient cells display increased susceptibility to arsenite-induced cell death, which is rescued by re-expressing TRIB3.	arsenite	58-66	tribbles pseudokinase 3	Mus musculus	0-5
27526673-5	2016	Trib3-deficient cells display increased susceptibility to arsenite-induced cell death, which is rescued by re-expressing TRIB3.	arsenite	58-66	tribbles pseudokinase 3	Mus musculus	121-126
27526673-6	2016	In cells lacking TRIB3, arsenite stress leads to markedly elevated mRNA and protein levels of Chac1, a gene that encodes a glutathione-degrading enzyme and is not previously known to be repressed by TRIB3.	arsenite	24-32	tribbles pseudokinase 3	Mus musculus	17-22
27526673-6	2016	In cells lacking TRIB3, arsenite stress leads to markedly elevated mRNA and protein levels of Chac1, a gene that encodes a glutathione-degrading enzyme and is not previously known to be repressed by TRIB3.	arsenite	24-32	ChaC, cation transport regulator 1	Mus musculus	94-99
27526673-6	2016	In cells lacking TRIB3, arsenite stress leads to markedly elevated mRNA and protein levels of Chac1, a gene that encodes a glutathione-degrading enzyme and is not previously known to be repressed by TRIB3.	arsenite	24-32	tribbles pseudokinase 3	Mus musculus	199-204
27526673-7	2016	Analysis of the Chac1 promoter identified two regulatory elements that additively mediate the induction of Chac1 by arsenite and ATF4, as well as the robust suppression of Chac1 by TRIB3.	arsenite	116-124	ChaC, cation transport regulator 1	Mus musculus	16-21
27526673-7	2016	Analysis of the Chac1 promoter identified two regulatory elements that additively mediate the induction of Chac1 by arsenite and ATF4, as well as the robust suppression of Chac1 by TRIB3.	arsenite	116-124	ChaC, cation transport regulator 1	Mus musculus	107-112
27526673-7	2016	Analysis of the Chac1 promoter identified two regulatory elements that additively mediate the induction of Chac1 by arsenite and ATF4, as well as the robust suppression of Chac1 by TRIB3.	arsenite	116-124	ChaC, cation transport regulator 1	Mus musculus	107-112
27526673-8	2016	Crucially, Chac1 silencing enhances glutathione levels and eliminates the increased susceptibility of Trib3-deficient cells to arsenite stress.	arsenite	127-135	ChaC, cation transport regulator 1	Mus musculus	11-16
27526673-8	2016	Crucially, Chac1 silencing enhances glutathione levels and eliminates the increased susceptibility of Trib3-deficient cells to arsenite stress.	arsenite	127-135	tribbles pseudokinase 3	Mus musculus	102-107
27526673-10	2016	Taken together, these data indicate that excessive Chac1 expression is detrimental to arsenite-treated cell survival and that TRIB3 is critical for restraining the pro-death potential of Chac1 during arsenite stress, representing a novel mechanism of cell viability regulation that occurs within the ATF4 pathway.	arsenite	200-208	tribbles pseudokinase 3	Mus musculus	126-131
27526673-10	2016	Taken together, these data indicate that excessive Chac1 expression is detrimental to arsenite-treated cell survival and that TRIB3 is critical for restraining the pro-death potential of Chac1 during arsenite stress, representing a novel mechanism of cell viability regulation that occurs within the ATF4 pathway.	arsenite	200-208	ChaC, cation transport regulator 1	Mus musculus	187-192
27428365-7	2016	AtMRP1 showed enhanced tolerance towards arsenite As(III) in yeast.	arsenite	41-49	multidrug resistance-associated protein 1	Arabidopsis thaliana	0-6
27428365-9	2016	AtMRP1-NBD2 and its serine mutants showed distinct change in secondary structure in the presence of arsenite and methotrexate (MTX) controlled by serine triad phosphorylation.	arsenite	100-108	multidrug resistance-associated protein 1	Arabidopsis thaliana	0-6
27607883-0	2016	The mitogen-activated protein kinase Slt2 modulates arsenite transport through the aquaglyceroporin Fps1.	arsenite	52-60	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	37-41
27601476-6	2016	Arsenite stress quickly and reversibly decreased asymmetric arginine methylation on G3BP1.	arsenite	0-8	G3BP stress granule assembly factor 1	Homo sapiens	84-89
27573237-7	2016	Arsenite, as well as other agents, triggered relocalization also of hEndoV to cytoplasmic stress granules.	arsenite	0-8	endonuclease V	Homo sapiens	68-74
27531258-0	2016	Elevated connexin 43 expression in arsenite-and cadmium-transformed human bladder cancer cells, tumor transplants and selected high grade human bladder cancers.	arsenite	35-43	gap junction protein alpha 1	Homo sapiens	9-20
27531258-4	2016	The goal of the present study was to determine if connexin 43 is expressed in the normal human bladder, the arsenite and cadmiun-transformed UROtsa cells as well as human urothelial cancer.	arsenite	108-116	gap junction protein alpha 1	Homo sapiens	50-61
27531258-5	2016	The results obtained showed that connexin 43 is not expressed in the epithelial cells of the human bladder but is expressed in immortalized cultures of human urothelial cells and the expression is variable in the arsenite and cadmium- transformed urothelial cell lines derived from these immortalized cells.	arsenite	213-221	gap junction protein alpha 1	Homo sapiens	33-44
27579588-0	2016	Transgenerational Reproductive Effects of Arsenite Are Associated with H3K4 Dimethylation and SPR-5 Downregulation in Caenorhabditis elegans.	arsenite	42-50	putative lysine-specific histone demethylase 1	Caenorhabditis elegans	94-99
27579588-7	2016	In addition, adult worms from F0 and F1 generations accumulated arsenite and arsenate when F0 L4 larvae were exposed to arsenite for 24 h. We found that the mRNA level of H3K4me2 demethylase LSD/KDM1, spr-5, was significantly reduced in the F0 exposed generation and subsequent unexposed generations (F1-F3).	arsenite	64-72	putative lysine-specific histone demethylase 1	Caenorhabditis elegans	201-206
27579588-7	2016	In addition, adult worms from F0 and F1 generations accumulated arsenite and arsenate when F0 L4 larvae were exposed to arsenite for 24 h. We found that the mRNA level of H3K4me2 demethylase LSD/KDM1, spr-5, was significantly reduced in the F0 exposed generation and subsequent unexposed generations (F1-F3).	arsenite	120-128	putative lysine-specific histone demethylase 1	Caenorhabditis elegans	201-206
27579588-10	2016	Our study demonstrates that maternal arsenite exposure causes transgenerational reproductive effects in C. elegans, which might be associated with H3K4 dimethylation and SPR-5 downregulation.	arsenite	37-45	putative lysine-specific histone demethylase 1	Caenorhabditis elegans	170-175
27481264-11	2016	Mutant SOD1 delayed the formation of G3BP1- and TIA1-positive stress granules in response to hyperosmolar shock and arsenite treatment in N2A cells.	arsenite	116-124	superoxide dismutase 1, soluble	Mus musculus	7-11
27481264-11	2016	Mutant SOD1 delayed the formation of G3BP1- and TIA1-positive stress granules in response to hyperosmolar shock and arsenite treatment in N2A cells.	arsenite	116-124	GTPase activating protein (SH3 domain) binding protein 1	Mus musculus	37-42
27481264-11	2016	Mutant SOD1 delayed the formation of G3BP1- and TIA1-positive stress granules in response to hyperosmolar shock and arsenite treatment in N2A cells.	arsenite	116-124	cytotoxic granule-associated RNA binding protein 1	Mus musculus	48-52
27607883-0	2016	The mitogen-activated protein kinase Slt2 modulates arsenite transport through the aquaglyceroporin Fps1.	arsenite	52-60	Fps1p	Saccharomyces cerevisiae S288C	100-104
27607883-2	2016	In yeast (Saccharomyces cerevisiae), the aquaglyceroporin Fps1 mediates arsenite influx and efflux.	arsenite	72-80	Fps1p	Saccharomyces cerevisiae S288C	58-62
27607883-3	2016	The mitogen-activated protein kinase (MAPK) Hog1 has previously been shown to restrict arsenite influx through Fps1.	arsenite	87-95	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	44-48
27607883-3	2016	The mitogen-activated protein kinase (MAPK) Hog1 has previously been shown to restrict arsenite influx through Fps1.	arsenite	87-95	Fps1p	Saccharomyces cerevisiae S288C	111-115
27607883-4	2016	In this study, we show that another MAPK, Slt2, is transiently phosphorylated in response to arsenite influx.	arsenite	93-101	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	42-46
27607883-5	2016	Our findings indicate that the protein kinase activity of Slt2 is required for its role in arsenite tolerance.	arsenite	91-99	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	58-62
27607883-6	2016	While Hog1 prevents arsenite influx via phosphorylation of T231 at the N-terminal domain of Fps1, Slt2 promotes arsenite efflux through phosphorylation of S537 at the C terminus.	arsenite	20-28	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	6-10
27607883-6	2016	While Hog1 prevents arsenite influx via phosphorylation of T231 at the N-terminal domain of Fps1, Slt2 promotes arsenite efflux through phosphorylation of S537 at the C terminus.	arsenite	112-120	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	98-102
27287256-0	2016	The lncRNA MALAT1, acting through HIF-1alpha stabilization, enhances arsenite-induced glycolysis in human hepatic L-02 cells.	arsenite	69-77	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	11-17
27286880-0	2016	Differential transcriptional regulation of hypoxia-inducible factor-1alpha by arsenite under normoxia and hypoxia: involvement of Nrf2.	arsenite	78-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-74
27517564-0	2016	Arsenite inhibits the function of CD133+ CD13+ liver cancer stem cells by reducing PML and Oct4 protein expression.	arsenite	0-8	prominin 1	Homo sapiens	34-39
27517564-0	2016	Arsenite inhibits the function of CD133+ CD13+ liver cancer stem cells by reducing PML and Oct4 protein expression.	arsenite	0-8	alanyl aminopeptidase, membrane	Homo sapiens	34-38
27517564-0	2016	Arsenite inhibits the function of CD133+ CD13+ liver cancer stem cells by reducing PML and Oct4 protein expression.	arsenite	0-8	PML nuclear body scaffold	Homo sapiens	83-86
27517564-0	2016	Arsenite inhibits the function of CD133+ CD13+ liver cancer stem cells by reducing PML and Oct4 protein expression.	arsenite	0-8	POU class 5 homeobox 1	Homo sapiens	91-95
27517564-3	2016	We also found that arsenite treatment reduced the viability and stemness of CD133+CD13+ hepatocytes, enhanced the sensitivity of HuH7 cells to pirarubicin, and reduced the tumorigenicity of CD133+CD13+ hepatocytes xenografts in mice.	arsenite	19-27	prominin 1	Homo sapiens	76-81
27517564-3	2016	We also found that arsenite treatment reduced the viability and stemness of CD133+CD13+ hepatocytes, enhanced the sensitivity of HuH7 cells to pirarubicin, and reduced the tumorigenicity of CD133+CD13+ hepatocytes xenografts in mice.	arsenite	19-27	alanyl aminopeptidase, membrane	Homo sapiens	76-80
27517564-3	2016	We also found that arsenite treatment reduced the viability and stemness of CD133+CD13+ hepatocytes, enhanced the sensitivity of HuH7 cells to pirarubicin, and reduced the tumorigenicity of CD133+CD13+ hepatocytes xenografts in mice.	arsenite	19-27	prominin 1	Homo sapiens	190-195
27517564-3	2016	We also found that arsenite treatment reduced the viability and stemness of CD133+CD13+ hepatocytes, enhanced the sensitivity of HuH7 cells to pirarubicin, and reduced the tumorigenicity of CD133+CD13+ hepatocytes xenografts in mice.	arsenite	19-27	alanyl aminopeptidase, membrane	Homo sapiens	82-86
27287256-0	2016	The lncRNA MALAT1, acting through HIF-1alpha stabilization, enhances arsenite-induced glycolysis in human hepatic L-02 cells.	arsenite	69-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-44
27287256-4	2016	We have found that, in human hepatic epithelial (L-02) cells, arsenite increases lactate production; glucose consumption; and expression of glycolysis-related genes, including HK-2, Eno-1, and Glut-4.	arsenite	62-70	hexokinase 2	Homo sapiens	176-180
27287256-4	2016	We have found that, in human hepatic epithelial (L-02) cells, arsenite increases lactate production; glucose consumption; and expression of glycolysis-related genes, including HK-2, Eno-1, and Glut-4.	arsenite	62-70	enolase 1	Homo sapiens	182-187
27287256-4	2016	We have found that, in human hepatic epithelial (L-02) cells, arsenite increases lactate production; glucose consumption; and expression of glycolysis-related genes, including HK-2, Eno-1, and Glut-4.	arsenite	62-70	solute carrier family 2 member 4	Homo sapiens	193-199
27287256-5	2016	In L-02 cells exposed to arsenite, the lncRNA, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), and hypoxia inducible factors (HIFs)-alpha, the transcriptional regulators of cellular response to hypoxia, are over-expressed.	arsenite	25-33	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	47-101
27287256-6	2016	In addition, HIF-1alpha, not HIF-2alpha, is involved in arsenite-induced glycolysis, and MALAT1 enhances arsenite-induced glycolysis.	arsenite	56-64	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-23
27287256-6	2016	In addition, HIF-1alpha, not HIF-2alpha, is involved in arsenite-induced glycolysis, and MALAT1 enhances arsenite-induced glycolysis.	arsenite	105-113	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	89-95
27287256-8	2016	Moreover, arsenite-increased MALAT1 enhances the disassociation of Von Hippel-Lindau (VHL) tumor suppressor from HIF-1alpha, alleviating VHL-mediated ubiquitination of HIF-1alpha, which causes accumulation of HIF-1alpha.	arsenite	10-18	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	29-35
27287256-8	2016	Moreover, arsenite-increased MALAT1 enhances the disassociation of Von Hippel-Lindau (VHL) tumor suppressor from HIF-1alpha, alleviating VHL-mediated ubiquitination of HIF-1alpha, which causes accumulation of HIF-1alpha.	arsenite	10-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	113-123
27287256-8	2016	Moreover, arsenite-increased MALAT1 enhances the disassociation of Von Hippel-Lindau (VHL) tumor suppressor from HIF-1alpha, alleviating VHL-mediated ubiquitination of HIF-1alpha, which causes accumulation of HIF-1alpha.	arsenite	10-18	von Hippel-Lindau tumor suppressor	Homo sapiens	86-89
27287256-8	2016	Moreover, arsenite-increased MALAT1 enhances the disassociation of Von Hippel-Lindau (VHL) tumor suppressor from HIF-1alpha, alleviating VHL-mediated ubiquitination of HIF-1alpha, which causes accumulation of HIF-1alpha.	arsenite	10-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	168-178
27287256-8	2016	Moreover, arsenite-increased MALAT1 enhances the disassociation of Von Hippel-Lindau (VHL) tumor suppressor from HIF-1alpha, alleviating VHL-mediated ubiquitination of HIF-1alpha, which causes accumulation of HIF-1alpha.	arsenite	10-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	168-178
27287256-9	2016	In sum, these findings indicate that MALAT1, acting through HIF-1alpha stabilization, is a mediator that enhances glycolysis induced by arsenite.	arsenite	136-144	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	37-43
27287256-9	2016	In sum, these findings indicate that MALAT1, acting through HIF-1alpha stabilization, is a mediator that enhances glycolysis induced by arsenite.	arsenite	136-144	hypoxia inducible factor 1 subunit alpha	Homo sapiens	60-70
27475902-0	2016	Arsenite suppresses angiogenesis of vascular endothelial cells mediated by Platelet Derived Growth Factor Receptor-beta.	arsenite	0-8	platelet derived growth factor receptor beta	Homo sapiens	75-119
27475902-5	2016	Finally by using porcine aortic endothelial cells which stably express human PDGFR-beta, we found that arsenite suppressed the angiogenesis mediated by PDGFR-beta.	arsenite	103-111	platelet derived growth factor receptor beta	Homo sapiens	77-87
27475902-5	2016	Finally by using porcine aortic endothelial cells which stably express human PDGFR-beta, we found that arsenite suppressed the angiogenesis mediated by PDGFR-beta.	arsenite	103-111	platelet derived growth factor receptor beta	Homo sapiens	152-162
27475902-6	2016	Based on these results, we conclude that arsenite suppressed the angiogenesis of the vascular endothelial cells, that this effect is mediated by PDGFR-beta, and postulate that it might contribute to the injuries of blood vessel in arsenism.	arsenite	41-49	platelet derived growth factor receptor beta	Homo sapiens	145-155
26731009-6	2016	Compared to the only DOX-loaded vesicle, the DOX-As-co-loaded one induced more than twice the apoptotic ratio of MCF-7/ADR breast cancer cells at a low As concentration (0.5 muM), due to the synergistic effects of DOX and As.	arsenite	49-51	latexin	Homo sapiens	174-177
27306194-4	2016	After treatment with 1mM sodium arsenite, the survival of nrf2a(fh318) larvae was significantly shorter than that of wild-type siblings, suggesting that Nrf2 protected the zebrafish larvae against high-dose arsenite exposure.	arsenite	32-40	nfe2 like bZIP transcription factor 2a	Danio rerio	153-157
27306194-5	2016	To understand the molecular basis of the Nrf2-dependent protection, we analyzed the gene expression profiles after arsenite exposure, and found that the genes involved in the antioxidative function (prdx1 and gclc), arsenic metabolism (gstp1) and xenobiotic elimination (abcc2) were induced in an Nrf2-dependent manner.	arsenite	115-123	nfe2 like bZIP transcription factor 2a	Danio rerio	41-45
27306194-5	2016	To understand the molecular basis of the Nrf2-dependent protection, we analyzed the gene expression profiles after arsenite exposure, and found that the genes involved in the antioxidative function (prdx1 and gclc), arsenic metabolism (gstp1) and xenobiotic elimination (abcc2) were induced in an Nrf2-dependent manner.	arsenite	115-123	peroxiredoxin 1	Danio rerio	199-204
27306194-5	2016	To understand the molecular basis of the Nrf2-dependent protection, we analyzed the gene expression profiles after arsenite exposure, and found that the genes involved in the antioxidative function (prdx1 and gclc), arsenic metabolism (gstp1) and xenobiotic elimination (abcc2) were induced in an Nrf2-dependent manner.	arsenite	115-123	glutamate-cysteine ligase, catalytic subunit	Danio rerio	209-213
27306194-5	2016	To understand the molecular basis of the Nrf2-dependent protection, we analyzed the gene expression profiles after arsenite exposure, and found that the genes involved in the antioxidative function (prdx1 and gclc), arsenic metabolism (gstp1) and xenobiotic elimination (abcc2) were induced in an Nrf2-dependent manner.	arsenite	115-123	glutathione S-transferase pi 1.2	Danio rerio	236-241
27306194-5	2016	To understand the molecular basis of the Nrf2-dependent protection, we analyzed the gene expression profiles after arsenite exposure, and found that the genes involved in the antioxidative function (prdx1 and gclc), arsenic metabolism (gstp1) and xenobiotic elimination (abcc2) were induced in an Nrf2-dependent manner.	arsenite	115-123	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Danio rerio	271-276
27306194-5	2016	To understand the molecular basis of the Nrf2-dependent protection, we analyzed the gene expression profiles after arsenite exposure, and found that the genes involved in the antioxidative function (prdx1 and gclc), arsenic metabolism (gstp1) and xenobiotic elimination (abcc2) were induced in an Nrf2-dependent manner.	arsenite	115-123	nfe2 like bZIP transcription factor 2a	Danio rerio	297-301
27578149-6	2016	We also highlighted that eIF4E2 may exhibit distinct functions under different stresses as it readily localizes to P-bodies during arsenite and heat stresses, whereas it is redirected to stress granules only upon heat shock.	arsenite	131-139	eukaryotic translation initiation factor 4E family member 2	Homo sapiens	25-31
27484730-0	2016	Arsenite-loaded nanoparticles inhibit PARP-1 to overcome multidrug resistance in hepatocellular carcinoma cells.	arsenite	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	38-44
27484730-2	2016	Herein, we report an arsenite-loaded dual-drug (doxorubicin and arsenic trioxide, i.e., DOX and ATO) nanomedicine system (FeAsOx@SiO2-DOX, Combo NP) with significant drug synergy and pH-triggered drug release for effective treatment of DOX resistant HCC cells (HuH-7/ADM).	arsenite	21-29	MIR7-3 host gene	Homo sapiens	261-266
26438402-7	2016	Conversely, MEF Ogg1 (+/+) cells did not present changes in morphology or proliferation, exhibited a milder degree of gene deregulation and needed 10 weeks of additional exposure to the highest arsenite doses to show tumor enhancing effects.	arsenite	194-202	8-oxoguanine DNA glycosylase	Homo sapiens	16-20
27345716-8	2016	It was also observed that reduced expression of NRG2 led to marginal increase in cell survival under arsenite-induced stress.	arsenite	101-109	neuregulin 2	Homo sapiens	48-52
27107786-0	2016	MicroRNA-21 activation of ERK signaling via PTEN is involved in arsenite-induced autophagy in human hepatic L-02 cells.	arsenite	64-72	microRNA 21	Homo sapiens	0-11
27381497-5	2016	We show that SRSF3 is selectively neddylated at Lys85 in response to arsenite.	arsenite	69-77	serine and arginine rich splicing factor 3	Homo sapiens	13-18
27347121-6	2016	In AsPC-1 cells, the levels of cyclin D1 and phosphorylated retinoblastoma protein decreased following treatment with arsenite, but this was not observed in BxPC-3 cells.	arsenite	118-126	cyclin D1	Homo sapiens	31-40
27347121-7	2016	To further examine the differences between these two cell lines, the effect of arsenite on upstream p44/p42 mitogen-activated protein kinase (MAPK) and Akt was investigated.	arsenite	79-87	interferon induced protein 44	Homo sapiens	100-103
27347121-7	2016	To further examine the differences between these two cell lines, the effect of arsenite on upstream p44/p42 mitogen-activated protein kinase (MAPK) and Akt was investigated.	arsenite	79-87	mitogen-activated protein kinase 1	Homo sapiens	142-146
27347121-9	2016	Pretreatment with arsenite significantly suppressed PDGF-BB-induced phosphorylation of Akt, but not of p44/p42 MAPK in AsPC-1 cells.	arsenite	18-26	AKT serine/threonine kinase 1	Homo sapiens	87-90
27347121-11	2016	Since the inhibition of the Akt signaling pathway markedly reduced PDGF-BB-induced migration in AsPC-1 cells, the present results strongly suggest that arsenite inhibits PDGF-BB-induced migration by suppressing the Akt signaling pathway in AsPC-1 cells.	arsenite	152-160	AKT serine/threonine kinase 1	Homo sapiens	28-31
27347121-11	2016	Since the inhibition of the Akt signaling pathway markedly reduced PDGF-BB-induced migration in AsPC-1 cells, the present results strongly suggest that arsenite inhibits PDGF-BB-induced migration by suppressing the Akt signaling pathway in AsPC-1 cells.	arsenite	152-160	AKT serine/threonine kinase 1	Homo sapiens	215-218
27071941-0	2016	Arsenite and Cadmium Activate MAPK/ERK via Membrane Estrogen Receptors and G-Protein Coupled Estrogen Receptor Signaling in Human Lung Adenocarcinoma Cells.	arsenite	0-8	mitogen-activated protein kinase 1	Homo sapiens	35-38
27174133-12	2016	significantly inhibited (p < 0.05) arsenite-induced increased cardiac markers (LDH, CK-MB, AST, ALT, and ALP) and altered lipid metabolism (total cholesterol, triglyceride, LDL, HDL, and VLDL).	arsenite	38-46	PDZ and LIM domain 3	Rattus norvegicus	108-111
27174133-16	2016	Arsenite-induced alteration in heart Nrf-2, HO-1, Smad-3, and TGF-beta mRNA expression were significantly restored (p < 0.05) by naringin (40 and 80 mg/kg) treatment.	arsenite	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	37-42
27174133-16	2016	Arsenite-induced alteration in heart Nrf-2, HO-1, Smad-3, and TGF-beta mRNA expression were significantly restored (p < 0.05) by naringin (40 and 80 mg/kg) treatment.	arsenite	0-8	heme oxygenase 1	Rattus norvegicus	44-48
27174133-16	2016	Arsenite-induced alteration in heart Nrf-2, HO-1, Smad-3, and TGF-beta mRNA expression were significantly restored (p < 0.05) by naringin (40 and 80 mg/kg) treatment.	arsenite	0-8	SMAD family member 3	Rattus norvegicus	50-56
27174133-16	2016	Arsenite-induced alteration in heart Nrf-2, HO-1, Smad-3, and TGF-beta mRNA expression were significantly restored (p < 0.05) by naringin (40 and 80 mg/kg) treatment.	arsenite	0-8	transforming growth factor, beta 1	Rattus norvegicus	62-70
27174133-19	2016	CONCLUSION: The results of present investigation suggest that naringin ameliorates arsenite-induced cardiotoxicity via modulation of TGF-beta/Smad-3 and Nrf-2/HO-1 pathways along with a reduction in myocardial apoptosis.	arsenite	83-91	transforming growth factor, beta 1	Rattus norvegicus	133-141
27174133-19	2016	CONCLUSION: The results of present investigation suggest that naringin ameliorates arsenite-induced cardiotoxicity via modulation of TGF-beta/Smad-3 and Nrf-2/HO-1 pathways along with a reduction in myocardial apoptosis.	arsenite	83-91	SMAD family member 3	Rattus norvegicus	142-148
27174133-19	2016	CONCLUSION: The results of present investigation suggest that naringin ameliorates arsenite-induced cardiotoxicity via modulation of TGF-beta/Smad-3 and Nrf-2/HO-1 pathways along with a reduction in myocardial apoptosis.	arsenite	83-91	NFE2 like bZIP transcription factor 2	Rattus norvegicus	153-158
27174133-19	2016	CONCLUSION: The results of present investigation suggest that naringin ameliorates arsenite-induced cardiotoxicity via modulation of TGF-beta/Smad-3 and Nrf-2/HO-1 pathways along with a reduction in myocardial apoptosis.	arsenite	83-91	heme oxygenase 1	Rattus norvegicus	159-163
27160682-7	2016	We demonstrate that sumoylation of eIF4A2 is modestly increased in response to arsenite and ionising radiation, but decreases in response to heat shock or hippuristanol.	arsenite	79-87	eukaryotic translation initiation factor 4A2	Homo sapiens	35-41
27160682-8	2016	In arsenite-treated cells, but not in hippuristanol-treated cells, eIF4A2 is recruited to stress granules, suggesting sumoylation of eIF4A2 correlates with its recruitment to stress granules.	arsenite	3-11	eukaryotic translation initiation factor 4A2	Homo sapiens	67-73
27160682-8	2016	In arsenite-treated cells, but not in hippuristanol-treated cells, eIF4A2 is recruited to stress granules, suggesting sumoylation of eIF4A2 correlates with its recruitment to stress granules.	arsenite	3-11	eukaryotic translation initiation factor 4A2	Homo sapiens	133-139
27107786-0	2016	MicroRNA-21 activation of ERK signaling via PTEN is involved in arsenite-induced autophagy in human hepatic L-02 cells.	arsenite	64-72	mitogen-activated protein kinase 1	Homo sapiens	26-29
27107786-0	2016	MicroRNA-21 activation of ERK signaling via PTEN is involved in arsenite-induced autophagy in human hepatic L-02 cells.	arsenite	64-72	phosphatase and tensin homolog	Homo sapiens	44-48
27107786-5	2016	Arsenite also activates the ERK pathway in a dose- and time-dependent manner.	arsenite	0-8	mitogen-activated protein kinase 1	Homo sapiens	28-31
27107786-6	2016	In L-02 cells exposed to arsenite, microRNA-21 (miRNA-21) is over-expressed, and its target proteins, PTEN, PDCD4, and Spry1, are decreased.	arsenite	25-33	microRNA 21	Homo sapiens	35-46
27107786-6	2016	In L-02 cells exposed to arsenite, microRNA-21 (miRNA-21) is over-expressed, and its target proteins, PTEN, PDCD4, and Spry1, are decreased.	arsenite	25-33	microRNA 21	Homo sapiens	48-56
27107786-6	2016	In L-02 cells exposed to arsenite, microRNA-21 (miRNA-21) is over-expressed, and its target proteins, PTEN, PDCD4, and Spry1, are decreased.	arsenite	25-33	phosphatase and tensin homolog	Homo sapiens	102-106
27107786-6	2016	In L-02 cells exposed to arsenite, microRNA-21 (miRNA-21) is over-expressed, and its target proteins, PTEN, PDCD4, and Spry1, are decreased.	arsenite	25-33	programmed cell death 4	Homo sapiens	108-113
27107786-6	2016	In L-02 cells exposed to arsenite, microRNA-21 (miRNA-21) is over-expressed, and its target proteins, PTEN, PDCD4, and Spry1, are decreased.	arsenite	25-33	sprouty RTK signaling antagonist 1	Homo sapiens	119-124
27107786-7	2016	Moreover, inhibition of miR-21 increases levels of PTEN, and reduces levels of Beclin 1 and LC3 II/I, indicating that miR-21 is involved in arsenite-induced autophagy.	arsenite	140-148	microRNA 21	Homo sapiens	24-30
27107786-7	2016	Moreover, inhibition of miR-21 increases levels of PTEN, and reduces levels of Beclin 1 and LC3 II/I, indicating that miR-21 is involved in arsenite-induced autophagy.	arsenite	140-148	phosphatase and tensin homolog	Homo sapiens	51-55
27107786-7	2016	Moreover, inhibition of miR-21 increases levels of PTEN, and reduces levels of Beclin 1 and LC3 II/I, indicating that miR-21 is involved in arsenite-induced autophagy.	arsenite	140-148	beclin 1	Homo sapiens	79-87
27107786-7	2016	Moreover, inhibition of miR-21 increases levels of PTEN, and reduces levels of Beclin 1 and LC3 II/I, indicating that miR-21 is involved in arsenite-induced autophagy.	arsenite	140-148	microRNA 21	Homo sapiens	118-124
27107786-8	2016	In addition, ectopic expression of PTEN blocks the effect of miR-21 on the arsenite-induced autophagy and decreases p-ERK levels.	arsenite	75-83	phosphatase and tensin homolog	Homo sapiens	35-39
27107786-8	2016	In addition, ectopic expression of PTEN blocks the effect of miR-21 on the arsenite-induced autophagy and decreases p-ERK levels.	arsenite	75-83	microRNA 21	Homo sapiens	61-67
27107786-9	2016	Also, ERK promotes the autophagy induced by arsenite.	arsenite	44-52	mitogen-activated protein kinase 1	Homo sapiens	6-9
27107786-10	2016	In sum, upon exposure of cells to arsenite, over-expression of miR-21 activates ERK through PTEN, factors that participate in arsenite-induced autophagy.	arsenite	34-42	microRNA 21	Homo sapiens	63-69
27107786-10	2016	In sum, upon exposure of cells to arsenite, over-expression of miR-21 activates ERK through PTEN, factors that participate in arsenite-induced autophagy.	arsenite	34-42	mitogen-activated protein kinase 1	Homo sapiens	80-83
27107786-10	2016	In sum, upon exposure of cells to arsenite, over-expression of miR-21 activates ERK through PTEN, factors that participate in arsenite-induced autophagy.	arsenite	34-42	phosphatase and tensin homolog	Homo sapiens	92-96
27107786-10	2016	In sum, upon exposure of cells to arsenite, over-expression of miR-21 activates ERK through PTEN, factors that participate in arsenite-induced autophagy.	arsenite	126-134	microRNA 21	Homo sapiens	63-69
27107786-10	2016	In sum, upon exposure of cells to arsenite, over-expression of miR-21 activates ERK through PTEN, factors that participate in arsenite-induced autophagy.	arsenite	126-134	mitogen-activated protein kinase 1	Homo sapiens	80-83
27107786-10	2016	In sum, upon exposure of cells to arsenite, over-expression of miR-21 activates ERK through PTEN, factors that participate in arsenite-induced autophagy.	arsenite	126-134	phosphatase and tensin homolog	Homo sapiens	92-96
26104857-0	2016	Synergistic augmentation of ATP-induced interleukin-6 production by arsenite in HaCaT cells.	arsenite	68-76	interleukin 6	Homo sapiens	40-53
27106762-4	2016	AurkB and its downstream target histone-3 are phosphorylated during arsenite-induced stress.	arsenite	68-76	aurora kinase B	Homo sapiens	0-5
27106764-3	2016	Here, we investigated the role of VCP in cellular stress and found that the oxidative stressor arsenite and heat shock-activated stress responses evident by T-intracellular antigen-1-positive granules in C2C12 myoblasts.	arsenite	95-103	valosin containing protein	Mus musculus	34-37
26921788-0	2016	Environmentally relevant concentrations of arsenite and monomethylarsonous acid inhibit IL-7/STAT5 cytokine signaling pathways in mouse CD3+CD4-CD8- double negative thymus cells.	arsenite	43-51	interleukin 7	Mus musculus	88-92
30090420-0	2016	MicroRNA-21 activation of Akt via PTEN is involved in the epithelial-mesenchymal transition and malignant transformation of human keratinocytes induced by arsenite.	arsenite	155-163	microRNA 21	Homo sapiens	0-11
30090420-0	2016	MicroRNA-21 activation of Akt via PTEN is involved in the epithelial-mesenchymal transition and malignant transformation of human keratinocytes induced by arsenite.	arsenite	155-163	AKT serine/threonine kinase 1	Homo sapiens	26-29
30090420-0	2016	MicroRNA-21 activation of Akt via PTEN is involved in the epithelial-mesenchymal transition and malignant transformation of human keratinocytes induced by arsenite.	arsenite	155-163	phosphatase and tensin homolog	Homo sapiens	34-38
30090420-5	2016	In HaCaT cells, arsenite caused an increase of miR-21 levels and a decrease of PTEN, which activated Akt signaling and induced the EMT.	arsenite	16-24	microRNA 21	Homo sapiens	47-53
30090420-5	2016	In HaCaT cells, arsenite caused an increase of miR-21 levels and a decrease of PTEN, which activated Akt signaling and induced the EMT.	arsenite	16-24	phosphatase and tensin homolog	Homo sapiens	79-83
30090420-5	2016	In HaCaT cells, arsenite caused an increase of miR-21 levels and a decrease of PTEN, which activated Akt signaling and induced the EMT.	arsenite	16-24	AKT serine/threonine kinase 1	Homo sapiens	101-104
26796881-0	2016	Arsenite exposure accelerates aging process regulated by the transcription factor DAF-16/FOXO in Caenorhabditis elegans.	arsenite	0-8	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	82-88
26796881-7	2016	Moreover, the mRNA levels of transcriptional makers of aging (hsp-16.1, hsp-16.49, and hsp-70) were increased in aged worms under arsenite exposure (100 muM).	arsenite	130-138	Heat shock protein Hsp-16.1/Hsp-16.11	Caenorhabditis elegans	62-70
26796881-7	2016	Moreover, the mRNA levels of transcriptional makers of aging (hsp-16.1, hsp-16.49, and hsp-70) were increased in aged worms under arsenite exposure (100 muM).	arsenite	130-138	Heat shock protein Hsp-16.48/Hsp-16.49	Caenorhabditis elegans	72-81
26796881-7	2016	Moreover, the mRNA levels of transcriptional makers of aging (hsp-16.1, hsp-16.49, and hsp-70) were increased in aged worms under arsenite exposure (100 muM).	arsenite	130-138	Heat Shock Protein	Caenorhabditis elegans	87-93
26796881-8	2016	Finally, we showed that daf-16 mutant worms were more sensitive to arsenite exposure (100 muM) on lifespan and failed to induce the expression of its target gene sod-3 in aged daf-16 mutant under arsenite exposure (100 muM).	arsenite	67-75	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	24-30
26796881-10	2016	The overproduction of intracellular ROS and the transcription factor DAF-16/FOXO play roles in mediating the accelerated aging process by arsenite exposure in C. elegans.	arsenite	138-146	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	69-75
26921788-0	2016	Environmentally relevant concentrations of arsenite and monomethylarsonous acid inhibit IL-7/STAT5 cytokine signaling pathways in mouse CD3+CD4-CD8- double negative thymus cells.	arsenite	43-51	signal transducer and activator of transcription 5A	Mus musculus	93-98
26921788-0	2016	Environmentally relevant concentrations of arsenite and monomethylarsonous acid inhibit IL-7/STAT5 cytokine signaling pathways in mouse CD3+CD4-CD8- double negative thymus cells.	arsenite	43-51	CD3 antigen, epsilon polypeptide	Mus musculus	136-139
26921788-0	2016	Environmentally relevant concentrations of arsenite and monomethylarsonous acid inhibit IL-7/STAT5 cytokine signaling pathways in mouse CD3+CD4-CD8- double negative thymus cells.	arsenite	43-51	CD4 antigen	Mus musculus	140-143
25787150-2	2016	Our previous studies demonstrated that arsenite exposure for 24 h induces G0/G1 arrest in mouse B lymphoma A20 cells and the arrest is caused through induction of cyclin-dependent kinase inhibitor p16(INK4a) followed by accumulation of an Rb family protein, p130.	arsenite	39-47	cyclin dependent kinase inhibitor 2A	Mus musculus	201-206
25787150-2	2016	Our previous studies demonstrated that arsenite exposure for 24 h induces G0/G1 arrest in mouse B lymphoma A20 cells and the arrest is caused through induction of cyclin-dependent kinase inhibitor p16(INK4a) followed by accumulation of an Rb family protein, p130.	arsenite	39-47	cyclin dependent kinase inhibitor 2A	Mus musculus	197-200
25787150-2	2016	Our previous studies demonstrated that arsenite exposure for 24 h induces G0/G1 arrest in mouse B lymphoma A20 cells and the arrest is caused through induction of cyclin-dependent kinase inhibitor p16(INK4a) followed by accumulation of an Rb family protein, p130.	arsenite	39-47	nucleolar and coiled-body phosphoprotein 1	Mus musculus	258-262
25787150-5	2016	The long-term arsenite exposure also induced up-regulation of p16(INK4a) followed by robust accumulation of p130 and activation of the p53 pathway.	arsenite	14-22	cyclin dependent kinase inhibitor 2A	Mus musculus	62-65
25787150-5	2016	The long-term arsenite exposure also induced up-regulation of p16(INK4a) followed by robust accumulation of p130 and activation of the p53 pathway.	arsenite	14-22	cyclin dependent kinase inhibitor 2A	Mus musculus	66-71
25787150-5	2016	The long-term arsenite exposure also induced up-regulation of p16(INK4a) followed by robust accumulation of p130 and activation of the p53 pathway.	arsenite	14-22	nucleolar and coiled-body phosphoprotein 1	Mus musculus	108-112
26296331-0	2016	Role of PTEN-Akt-CREB Signaling Pathway in Nervous System impairment of Rats with Chronic Arsenite Exposure.	arsenite	90-98	phosphatase and tensin homolog	Rattus norvegicus	8-12
25787150-5	2016	The long-term arsenite exposure also induced up-regulation of p16(INK4a) followed by robust accumulation of p130 and activation of the p53 pathway.	arsenite	14-22	transformation related protein 53, pseudogene	Mus musculus	135-138
26296331-0	2016	Role of PTEN-Akt-CREB Signaling Pathway in Nervous System impairment of Rats with Chronic Arsenite Exposure.	arsenite	90-98	AKT serine/threonine kinase 1	Rattus norvegicus	13-16
26296331-0	2016	Role of PTEN-Akt-CREB Signaling Pathway in Nervous System impairment of Rats with Chronic Arsenite Exposure.	arsenite	90-98	cAMP responsive element binding protein 1	Rattus norvegicus	17-21
25787150-6	2016	Knockdown experiments with siRNA showed that p130 accumulation is essential for cell cycle arrest by long-term arsenite exposure.	arsenite	111-119	nucleolar and coiled-body phosphoprotein 1	Mus musculus	45-49
26296331-7	2016	Moreover, the protein levels of PTEN and Akt in brain tissue were not significantly changed compared with the control group, but p-Akt, CREB, and p-CREB were all significantly downregulated in arsenite-exposed groups with a dose-dependent pattern.	arsenite	193-201	phosphatase and tensin homolog	Rattus norvegicus	32-36
25787150-8	2016	We found that a variety of DNA repair-related genes were significantly down-regulated from 24 h of arsenite exposure and activation-induced cytidine deaminase was greatly up-regulated after long-term arsenite exposure.	arsenite	200-208	activation-induced cytidine deaminase	Mus musculus	121-158
26296331-7	2016	Moreover, the protein levels of PTEN and Akt in brain tissue were not significantly changed compared with the control group, but p-Akt, CREB, and p-CREB were all significantly downregulated in arsenite-exposed groups with a dose-dependent pattern.	arsenite	193-201	AKT serine/threonine kinase 1	Rattus norvegicus	41-44
26296331-7	2016	Moreover, the protein levels of PTEN and Akt in brain tissue were not significantly changed compared with the control group, but p-Akt, CREB, and p-CREB were all significantly downregulated in arsenite-exposed groups with a dose-dependent pattern.	arsenite	193-201	AKT serine/threonine kinase 1	Rattus norvegicus	131-134
26296331-7	2016	Moreover, the protein levels of PTEN and Akt in brain tissue were not significantly changed compared with the control group, but p-Akt, CREB, and p-CREB were all significantly downregulated in arsenite-exposed groups with a dose-dependent pattern.	arsenite	193-201	cAMP responsive element binding protein 1	Rattus norvegicus	136-140
26296331-7	2016	Moreover, the protein levels of PTEN and Akt in brain tissue were not significantly changed compared with the control group, but p-Akt, CREB, and p-CREB were all significantly downregulated in arsenite-exposed groups with a dose-dependent pattern.	arsenite	193-201	cAMP responsive element binding protein 1	Rattus norvegicus	148-152
25787150-9	2016	Consistent with these findings, long-term arsenite exposure increased a DNA double-strand break marker, gamma-H2AX and increased mutation frequency in a Bcl6 gene region.	arsenite	42-50	H2A.X variant histone	Mus musculus	104-114
26296331-8	2016	These results suggested that chronic arsenite exposure negatively regulated the PTEN-Akt-CREB signaling pathway, and dysfunction of the signaling pathway might be one of the mechanisms of nervous system impairment induced by chronic arsenite exposure.	arsenite	37-45	phosphatase and tensin homolog	Rattus norvegicus	80-84
26296331-8	2016	These results suggested that chronic arsenite exposure negatively regulated the PTEN-Akt-CREB signaling pathway, and dysfunction of the signaling pathway might be one of the mechanisms of nervous system impairment induced by chronic arsenite exposure.	arsenite	37-45	AKT serine/threonine kinase 1	Rattus norvegicus	85-88
26296331-8	2016	These results suggested that chronic arsenite exposure negatively regulated the PTEN-Akt-CREB signaling pathway, and dysfunction of the signaling pathway might be one of the mechanisms of nervous system impairment induced by chronic arsenite exposure.	arsenite	37-45	cAMP responsive element binding protein 1	Rattus norvegicus	89-93
26296331-8	2016	These results suggested that chronic arsenite exposure negatively regulated the PTEN-Akt-CREB signaling pathway, and dysfunction of the signaling pathway might be one of the mechanisms of nervous system impairment induced by chronic arsenite exposure.	arsenite	233-241	phosphatase and tensin homolog	Rattus norvegicus	80-84
26296331-8	2016	These results suggested that chronic arsenite exposure negatively regulated the PTEN-Akt-CREB signaling pathway, and dysfunction of the signaling pathway might be one of the mechanisms of nervous system impairment induced by chronic arsenite exposure.	arsenite	233-241	AKT serine/threonine kinase 1	Rattus norvegicus	85-88
26296331-8	2016	These results suggested that chronic arsenite exposure negatively regulated the PTEN-Akt-CREB signaling pathway, and dysfunction of the signaling pathway might be one of the mechanisms of nervous system impairment induced by chronic arsenite exposure.	arsenite	233-241	cAMP responsive element binding protein 1	Rattus norvegicus	89-93
25787150-9	2016	Consistent with these findings, long-term arsenite exposure increased a DNA double-strand break marker, gamma-H2AX and increased mutation frequency in a Bcl6 gene region.	arsenite	42-50	B cell leukemia/lymphoma 6	Mus musculus	153-157
25787150-10	2016	These results revealed that long-term arsenite exposure induces premature senescence through DNA damage increase and p130 accumulation in lymphoid cells.	arsenite	38-46	nucleolar and coiled-body phosphoprotein 1	Mus musculus	117-121
26864988-5	2016	This conceptual self-powered arsenic biosensor demonstrated limits of detection (LODs) of 13 muM for arsenite and 132 muM for arsenate.	arsenite	101-109	latexin	Homo sapiens	93-96
26581878-4	2016	Moreover, mRNA expression levels were evaluated by RT-PCR for DNMT1, DNMT3A, DNMT3B, HMLH1, and HMSH2 genes, demonstrating that the down regulation of DNMT3A and DNMT3B genes, but not DNMT1, occurred in an arsenic dose-dependent manner, and persisted for many cell generations following removal of the arsenite, offering a plausible mechanism of persistently genotoxic arsenic action.	arsenite	302-310	DNA methyltransferase 1	Homo sapiens	62-67
26581878-4	2016	Moreover, mRNA expression levels were evaluated by RT-PCR for DNMT1, DNMT3A, DNMT3B, HMLH1, and HMSH2 genes, demonstrating that the down regulation of DNMT3A and DNMT3B genes, but not DNMT1, occurred in an arsenic dose-dependent manner, and persisted for many cell generations following removal of the arsenite, offering a plausible mechanism of persistently genotoxic arsenic action.	arsenite	302-310	DNA methyltransferase 3 alpha	Homo sapiens	69-75
26581878-4	2016	Moreover, mRNA expression levels were evaluated by RT-PCR for DNMT1, DNMT3A, DNMT3B, HMLH1, and HMSH2 genes, demonstrating that the down regulation of DNMT3A and DNMT3B genes, but not DNMT1, occurred in an arsenic dose-dependent manner, and persisted for many cell generations following removal of the arsenite, offering a plausible mechanism of persistently genotoxic arsenic action.	arsenite	302-310	DNA methyltransferase 3 beta	Homo sapiens	77-83
26581878-4	2016	Moreover, mRNA expression levels were evaluated by RT-PCR for DNMT1, DNMT3A, DNMT3B, HMLH1, and HMSH2 genes, demonstrating that the down regulation of DNMT3A and DNMT3B genes, but not DNMT1, occurred in an arsenic dose-dependent manner, and persisted for many cell generations following removal of the arsenite, offering a plausible mechanism of persistently genotoxic arsenic action.	arsenite	302-310	mutL homolog 1	Homo sapiens	85-90
26581878-4	2016	Moreover, mRNA expression levels were evaluated by RT-PCR for DNMT1, DNMT3A, DNMT3B, HMLH1, and HMSH2 genes, demonstrating that the down regulation of DNMT3A and DNMT3B genes, but not DNMT1, occurred in an arsenic dose-dependent manner, and persisted for many cell generations following removal of the arsenite, offering a plausible mechanism of persistently genotoxic arsenic action.	arsenite	302-310	mutS homolog 2	Homo sapiens	96-101
26581878-4	2016	Moreover, mRNA expression levels were evaluated by RT-PCR for DNMT1, DNMT3A, DNMT3B, HMLH1, and HMSH2 genes, demonstrating that the down regulation of DNMT3A and DNMT3B genes, but not DNMT1, occurred in an arsenic dose-dependent manner, and persisted for many cell generations following removal of the arsenite, offering a plausible mechanism of persistently genotoxic arsenic action.	arsenite	302-310	DNA methyltransferase 3 alpha	Homo sapiens	151-157
26581878-4	2016	Moreover, mRNA expression levels were evaluated by RT-PCR for DNMT1, DNMT3A, DNMT3B, HMLH1, and HMSH2 genes, demonstrating that the down regulation of DNMT3A and DNMT3B genes, but not DNMT1, occurred in an arsenic dose-dependent manner, and persisted for many cell generations following removal of the arsenite, offering a plausible mechanism of persistently genotoxic arsenic action.	arsenite	302-310	DNA methyltransferase 3 beta	Homo sapiens	162-168
26735578-3	2016	We have found that MALAT1, a non-coding RNA, is over-expressed in the sera of people exposed to arsenite and in hepatocellular carcinomas (HCCs), and MALAT1 has a close relation with the clinicopathological characteristics of HCC.	arsenite	96-104	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	19-25
26898223-1	2016	The Arabidopsis aquaglyceroporin NIP7;1 is involved in uptake and tolerance to the trivalent arsenic species arsenite.	arsenite	109-117	NOD26-like intrinsic protein 7;1	Arabidopsis thaliana	33-39
26876100-2	2016	Here we report selective binding of AIRAPL, a protein that associates with the proteasome upon exposure to arsenite, to Lys48-linked tri-ubiquitin chains.	arsenite	107-115	zinc finger AN1-type containing 2B	Homo sapiens	36-42
26735578-3	2016	We have found that MALAT1, a non-coding RNA, is over-expressed in the sera of people exposed to arsenite and in hepatocellular carcinomas (HCCs), and MALAT1 has a close relation with the clinicopathological characteristics of HCC.	arsenite	96-104	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	150-156
26735578-6	2016	In addition, arsenite-induced MALAT1 causes disassociation of the von Hippel-Lindau (VHL) protein from HIF-2alpha, therefore, alleviating VHL-mediated HIF-2alpha ubiquitination, which causes HIF-2alpha accumulation.	arsenite	13-21	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	30-36
26735578-6	2016	In addition, arsenite-induced MALAT1 causes disassociation of the von Hippel-Lindau (VHL) protein from HIF-2alpha, therefore, alleviating VHL-mediated HIF-2alpha ubiquitination, which causes HIF-2alpha accumulation.	arsenite	13-21	von Hippel-Lindau tumor suppressor	Homo sapiens	66-83
26735578-6	2016	In addition, arsenite-induced MALAT1 causes disassociation of the von Hippel-Lindau (VHL) protein from HIF-2alpha, therefore, alleviating VHL-mediated HIF-2alpha ubiquitination, which causes HIF-2alpha accumulation.	arsenite	13-21	endothelial PAS domain protein 1	Homo sapiens	103-113
26735578-7	2016	In turn, HIF-2alpha transcriptionally regulates MALAT1, thus forming a positive feedback loop to ensure expression of arsenite-induced MALAT1 and HIF-2alpha, which are involved in malignant transformation.	arsenite	118-126	endothelial PAS domain protein 1	Homo sapiens	9-19
26735578-7	2016	In turn, HIF-2alpha transcriptionally regulates MALAT1, thus forming a positive feedback loop to ensure expression of arsenite-induced MALAT1 and HIF-2alpha, which are involved in malignant transformation.	arsenite	118-126	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	48-54
26735578-7	2016	In turn, HIF-2alpha transcriptionally regulates MALAT1, thus forming a positive feedback loop to ensure expression of arsenite-induced MALAT1 and HIF-2alpha, which are involved in malignant transformation.	arsenite	118-126	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	135-141
26735578-7	2016	In turn, HIF-2alpha transcriptionally regulates MALAT1, thus forming a positive feedback loop to ensure expression of arsenite-induced MALAT1 and HIF-2alpha, which are involved in malignant transformation.	arsenite	118-126	endothelial PAS domain protein 1	Homo sapiens	146-156
26735578-8	2016	Moreover, MALAT1 and HIF-2alpha promote the invasive and metastatic capacities of arsenite-induced transformed L-02 cells and in HCC-LM3 cells.	arsenite	82-90	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	10-16
26735578-8	2016	Moreover, MALAT1 and HIF-2alpha promote the invasive and metastatic capacities of arsenite-induced transformed L-02 cells and in HCC-LM3 cells.	arsenite	82-90	endothelial PAS domain protein 1	Homo sapiens	21-31
26735578-11	2016	Together, these findings suggest that the MALAT1/HIF-2alpha feedback loop is involved in regulation of arsenite-induced malignant transformation.	arsenite	103-111	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	42-48
26735578-11	2016	Together, these findings suggest that the MALAT1/HIF-2alpha feedback loop is involved in regulation of arsenite-induced malignant transformation.	arsenite	103-111	endothelial PAS domain protein 1	Homo sapiens	49-59
26735578-12	2016	Our results not only confirm a novel mechanism involving reciprocal regulation between MALAT1 and HIF-2alpha, but also expand the understanding of the carcinogenic potential of arsenite.	arsenite	177-185	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	87-93
26735578-12	2016	Our results not only confirm a novel mechanism involving reciprocal regulation between MALAT1 and HIF-2alpha, but also expand the understanding of the carcinogenic potential of arsenite.	arsenite	177-185	endothelial PAS domain protein 1	Homo sapiens	98-108
25825268-8	2016	Gene expressions of hepatocellular carcinoma markers beta-catenin (CTNNB1) and interleukin-1 receptor antagonist in the tumors were significantly upregulated in the F2 males born to arsenite-F1 males compared to those born to the control F1 males.	arsenite	182-190	catenin (cadherin associated protein), beta 1	Mus musculus	53-65
26469543-3	2016	The maximum adsorptions of arsenite (As(III)) and arsenate (As(V)) appear at pH values 8 and 4, respectively.	arsenite	27-35	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	60-65
25825268-8	2016	Gene expressions of hepatocellular carcinoma markers beta-catenin (CTNNB1) and interleukin-1 receptor antagonist in the tumors were significantly upregulated in the F2 males born to arsenite-F1 males compared to those born to the control F1 males.	arsenite	182-190	catenin (cadherin associated protein), beta 1	Mus musculus	67-73
26692333-1	2016	AIRAPL (arsenite-inducible RNA-associated protein-like) is an evolutionarily conserved regulator of cellular proteostasis linked to longevity in nematodes, but its biological function in mammals is unknown.	arsenite	8-16	zinc finger AN1-type containing 2B	Homo sapiens	0-6
26409248-8	2015	Taken together, the present study strongly suggests that loss of Keap1 function by hypermethylation of its promoter region leading to Nrf2 nuclear accumulation appears to play a role in arsenite-induced human keratinocyte transformation.	arsenite	186-194	NFE2 like bZIP transcription factor 2	Homo sapiens	134-138
26443841-0	2016	Environmentally Relevant Concentrations of Arsenite Induce Dose-Dependent Differential Genotoxicity Through Poly(ADP-Ribose) Polymerase Inhibition and Oxidative Stress in Mouse Thymus Cells.	arsenite	43-51	poly (ADP-ribose) polymerase family, member 1	Mus musculus	108-135
26711267-3	2015	Here we demonstrate that Yap8 directly binds to trivalent arsenite [As(III)] in vitro and in vivo and that approximately one As(III) molecule is bound per molecule of Yap8.	arsenite	58-66	Arr1p	Saccharomyces cerevisiae S288C	25-29
26432159-0	2015	Roles of oxidative stress and the ERK1/2, PTEN and p70S6K signaling pathways in arsenite-induced autophagy.	arsenite	80-88	mitogen-activated protein kinase 3	Homo sapiens	34-40
26432159-0	2015	Roles of oxidative stress and the ERK1/2, PTEN and p70S6K signaling pathways in arsenite-induced autophagy.	arsenite	80-88	phosphatase and tensin homolog	Homo sapiens	42-46
26432159-0	2015	Roles of oxidative stress and the ERK1/2, PTEN and p70S6K signaling pathways in arsenite-induced autophagy.	arsenite	80-88	ribosomal protein S6 kinase B1	Homo sapiens	51-57
26432159-5	2015	Arsenite also increased the number of autophagosomes and increased levels of the autophagy markers Beclin-1 and microtubule-associated protein 1 light chain 3B.	arsenite	0-8	beclin 1	Homo sapiens	99-159
26432159-7	2015	Our previous work showed that arsenite induced phosphorylation of the ERK1/2 signaling pathway.	arsenite	30-38	mitogen-activated protein kinase 3	Homo sapiens	70-76
26432159-8	2015	The current study further showed that arsenite decreased phosphatase and tensin homologue (PTEN) levels and increased phospho-p70S6 kinase (p-p70S6K) in SV-HUC-1 cells.	arsenite	38-46	phosphatase and tensin homolog	Homo sapiens	57-89
26432159-8	2015	The current study further showed that arsenite decreased phosphatase and tensin homologue (PTEN) levels and increased phospho-p70S6 kinase (p-p70S6K) in SV-HUC-1 cells.	arsenite	38-46	phosphatase and tensin homolog	Homo sapiens	91-95
26432159-8	2015	The current study further showed that arsenite decreased phosphatase and tensin homologue (PTEN) levels and increased phospho-p70S6 kinase (p-p70S6K) in SV-HUC-1 cells.	arsenite	38-46	ribosomal protein S6 kinase B1	Homo sapiens	142-148
26432159-9	2015	However, both kinase inhibitor U0126 and the DNA (cytosine-5-)-methyltransferase 1 (DNMT1) inhibitor 5-aza-deoxycytidine abolished the effect of arsenite on expressions of PTEN and p-p70S6K.	arsenite	145-153	DNA methyltransferase 1	Homo sapiens	45-82
26432159-9	2015	However, both kinase inhibitor U0126 and the DNA (cytosine-5-)-methyltransferase 1 (DNMT1) inhibitor 5-aza-deoxycytidine abolished the effect of arsenite on expressions of PTEN and p-p70S6K.	arsenite	145-153	DNA methyltransferase 1	Homo sapiens	84-89
26432159-9	2015	However, both kinase inhibitor U0126 and the DNA (cytosine-5-)-methyltransferase 1 (DNMT1) inhibitor 5-aza-deoxycytidine abolished the effect of arsenite on expressions of PTEN and p-p70S6K.	arsenite	145-153	phosphatase and tensin homolog	Homo sapiens	172-176
26432159-9	2015	However, both kinase inhibitor U0126 and the DNA (cytosine-5-)-methyltransferase 1 (DNMT1) inhibitor 5-aza-deoxycytidine abolished the effect of arsenite on expressions of PTEN and p-p70S6K.	arsenite	145-153	ribosomal protein S6 kinase B1	Homo sapiens	183-189
26432159-10	2015	These results show that autophagy induced by arsenite exposure is mediated by oxidative stress, which regulates activation of the PTEN, p70S6K and ERK1/2 signaling pathways.	arsenite	45-53	phosphatase and tensin homolog	Homo sapiens	130-134
26432159-10	2015	These results show that autophagy induced by arsenite exposure is mediated by oxidative stress, which regulates activation of the PTEN, p70S6K and ERK1/2 signaling pathways.	arsenite	45-53	ribosomal protein S6 kinase B1	Homo sapiens	136-142
26432159-10	2015	These results show that autophagy induced by arsenite exposure is mediated by oxidative stress, which regulates activation of the PTEN, p70S6K and ERK1/2 signaling pathways.	arsenite	45-53	mitogen-activated protein kinase 3	Homo sapiens	147-153
26409248-0	2015	Hypermethylation of the Keap1 gene inactivates its function, promotes Nrf2 nuclear accumulation, and is involved in arsenite-induced human keratinocyte transformation.	arsenite	116-124	kelch like ECH associated protein 1	Homo sapiens	24-29
26409248-4	2015	By establishing transformed human keratinocyte cells via chronic arsenite treatment, we observed a continuous reduction in reactive oxygen species levels and enhanced levels of Nrf2 and its target antioxidant enzymes in the later stage of arsenite-induced cell transformation.	arsenite	65-73	NFE2 like bZIP transcription factor 2	Homo sapiens	177-181
26409248-4	2015	By establishing transformed human keratinocyte cells via chronic arsenite treatment, we observed a continuous reduction in reactive oxygen species levels and enhanced levels of Nrf2 and its target antioxidant enzymes in the later stage of arsenite-induced cell transformation.	arsenite	239-247	NFE2 like bZIP transcription factor 2	Homo sapiens	177-181
26409248-6	2015	To validate these observations, the expression of Keap1 protein was restored in arsenite-transformed cells by treatment with a DNA methyltransferase inhibitor, 5-aza-2"-deoxycytidine (5-Aza-dC), and protein levels of Nrf2 and colony formation were then determined after these treatments.	arsenite	80-88	kelch like ECH associated protein 1	Homo sapiens	50-55
26409248-6	2015	To validate these observations, the expression of Keap1 protein was restored in arsenite-transformed cells by treatment with a DNA methyltransferase inhibitor, 5-aza-2"-deoxycytidine (5-Aza-dC), and protein levels of Nrf2 and colony formation were then determined after these treatments.	arsenite	80-88	NFE2 like bZIP transcription factor 2	Homo sapiens	217-221
26409248-8	2015	Taken together, the present study strongly suggests that loss of Keap1 function by hypermethylation of its promoter region leading to Nrf2 nuclear accumulation appears to play a role in arsenite-induced human keratinocyte transformation.	arsenite	186-194	kelch like ECH associated protein 1	Homo sapiens	65-70
27004129-6	2016	Transformation of Saccharomyces cerevisiae with AtINT2 or AtINT4 led to increased arsenic accumulation and increased sensitivity to arsenite.	arsenite	132-140	inositol transporter 2	Arabidopsis thaliana	48-54
27004129-6	2016	Transformation of Saccharomyces cerevisiae with AtINT2 or AtINT4 led to increased arsenic accumulation and increased sensitivity to arsenite.	arsenite	132-140	inositol transporter 4	Arabidopsis thaliana	58-64
27004129-7	2016	Expression of AtINT2 in Xenopus laevis oocytes also induced arsenite import.	arsenite	60-68	inositol transporter 2	Arabidopsis thaliana	14-20
27004129-8	2016	Disruption of AtINT2 or AtINT4 in Arabidopsis thaliana led to a reduction in phloem, silique and seed arsenic concentrations in plants fed with arsenite through the roots, relative to wild-type plants.	arsenite	144-152	inositol transporter 2	Arabidopsis thaliana	14-20
27004129-8	2016	Disruption of AtINT2 or AtINT4 in Arabidopsis thaliana led to a reduction in phloem, silique and seed arsenic concentrations in plants fed with arsenite through the roots, relative to wild-type plants.	arsenite	144-152	inositol transporter 4	Arabidopsis thaliana	24-30
26420645-0	2015	Continuous activation of Nrf2 and its target antioxidant enzymes leads to arsenite-induced malignant transformation of human bronchial epithelial cells.	arsenite	74-82	NFE2 like bZIP transcription factor 2	Homo sapiens	25-29
26483381-7	2015	Moreover, exposure to arsenite induced expression of Sqstm1-GFP, followed by accumulation of the fusion protein in large aggregates that were degraded by autophagy.	arsenite	22-30	sequestosome 1	Mus musculus	53-59
26420645-4	2015	However, the role of Nrf2 in the occurrence of cancer induced by long-term arsenite exposure remains to be fully understood.	arsenite	75-83	NFE2 like bZIP transcription factor 2	Homo sapiens	21-25
26354774-0	2015	Arsenite Disrupts Zinc-Dependent TGFbeta2-SMAD Activity During Murine Cardiac Progenitor Cell Differentiation.	arsenite	0-8	transforming growth factor, beta 2	Mus musculus	33-41
26420645-5	2015	By establishing transformed human bronchial epithelial (HBE) cells via chronic low-dose arsenite treatment, we showed that, in acquiring this malignant phenotype, continuous low level of ROS and sustained enhancement of Nrf2 and its target antioxidant enzyme levels were observed in the later-stage of arsenite-induced cell transformation.	arsenite	88-96	NFE2 like bZIP transcription factor 2	Homo sapiens	220-224
26420645-5	2015	By establishing transformed human bronchial epithelial (HBE) cells via chronic low-dose arsenite treatment, we showed that, in acquiring this malignant phenotype, continuous low level of ROS and sustained enhancement of Nrf2 and its target antioxidant enzyme levels were observed in the later-stage of arsenite-induced cell transformation.	arsenite	302-310	NFE2 like bZIP transcription factor 2	Homo sapiens	220-224
26354774-4	2015	Arsenite exposure of 1.34 muM for 24-48 h has been reported to disrupt Smad phosphorylation leading to deficits in TGFbeta2-mediated cardiac precursor differentiation and transformation.	arsenite	0-8	transforming growth factor, beta 2	Mus musculus	115-123
26354774-5	2015	In this study, the molecular mechanism of acute arsenite toxicity on TGFbeta2-induced Smad2/3 nuclear shuttling and TGFbeta2-mediated cardiac EMT was investigated.	arsenite	48-56	transforming growth factor, beta 2	Mus musculus	69-77
26420645-7	2015	To validate these observations, Nrf2 was knocked down in arsenite-transformed HBE cells by SiRNA transfection, and the levels of Nrf2 and its target antioxidant enzymes, ROS, cell proliferation, migration, and colony formation were determined following these treatments.	arsenite	57-65	NFE2 like bZIP transcription factor 2	Homo sapiens	32-36
26420645-9	2015	In summary, the results of the study strongly suggested that the continuous activation of Nrf2 and its target antioxidant enzymes led to the over-depletion of intracellular ROS levels, which contributed to arsenite-induced HBE cell transformation.	arsenite	206-214	NFE2 like bZIP transcription factor 2	Homo sapiens	90-94
26354774-5	2015	In this study, the molecular mechanism of acute arsenite toxicity on TGFbeta2-induced Smad2/3 nuclear shuttling and TGFbeta2-mediated cardiac EMT was investigated.	arsenite	48-56	SMAD family member 2	Mus musculus	86-93
26354774-5	2015	In this study, the molecular mechanism of acute arsenite toxicity on TGFbeta2-induced Smad2/3 nuclear shuttling and TGFbeta2-mediated cardiac EMT was investigated.	arsenite	48-56	transforming growth factor, beta 2	Mus musculus	116-124
26823637-4	2015	The results of shaken batch bioassays indicated that the original, unexposed sludge was severely inhibited by arsenite (AsIII) as evidenced by the low 50% inhibition concentrations (IC50) determined, i.e., 19 and 90 muM for acetoclastic- and hydrogenotrophic methanogenesis, respectively.	arsenite	110-118	latexin	Homo sapiens	216-219
26354774-6	2015	A 4-h exposure to 5 muM arsenite blocks nuclear accumulation of Smad2/3 in response to TGFbeta2 without disrupting Smad phosphorylation or nuclear importation.	arsenite	24-32	SMAD family member 2	Mus musculus	64-71
26354774-6	2015	A 4-h exposure to 5 muM arsenite blocks nuclear accumulation of Smad2/3 in response to TGFbeta2 without disrupting Smad phosphorylation or nuclear importation.	arsenite	24-32	transforming growth factor, beta 2	Mus musculus	87-95
26354774-7	2015	The depletion of nuclear Smad is restored by knocking-down Smad-specific exportins, suggesting that arsenite augments Smad2/3 nuclear exportation.	arsenite	100-108	SMAD family member 2	Mus musculus	118-125
26354774-8	2015	The blockage in TGFbeta2-Smad signaling is likely due to the loss of Zn(2+) cofactor in Smad proteins, as Zn(2+) supplementation reverses the disruption in Smad2/3 nuclear translocation and transcriptional activity by arsenite.	arsenite	218-226	transforming growth factor, beta 2	Mus musculus	16-24
26291278-0	2015	Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme oxygenase-1 gene.	arsenite	75-83	NFE2 like bZIP transcription factor 2	Homo sapiens	26-30
30090327-0	2016	HIF-2alpha, acting via miR-191, is involved in angiogenesis and metastasis of arsenite-transformed HBE cells.	arsenite	78-86	endothelial PAS domain protein 1	Homo sapiens	0-10
26537450-5	2015	Both real-time PCR analysis and whole in-mount hybridization showed that folic acid significantly rescued the decrease in Dvr1 expression caused by arsenite.	arsenite	148-156	growth differentiation factor 3	Danio rerio	122-126
26537450-6	2015	Subsequently, our data demonstrated that arsenite significantly decreased cell viability and GDF1 mRNA and protein levels in HEK293ET cells, while folic acid reversed these effects.	arsenite	41-49	growth differentiation factor 1	Homo sapiens	93-97
26537450-8	2015	P66Shc knockdown significantly inhibited the production of ROS and the down-regulation of GDF1 induced by arsenite.	arsenite	106-114	growth differentiation factor 1	Homo sapiens	90-94
26528920-6	2015	In ~80% of cells treated with sodium arsenite (Ars) to induce cytoplasmic stress granules, the nuclear localization of WT and F115C mutant Matrin 3 was not disturbed.	arsenite	47-50	matrin 3	Homo sapiens	139-147
26291278-8	2015	In response to arsenite, binding of Nrf2 to the HO-1 ARE preceded phosphorylation of H3S10 at the HO-1 ARE.	arsenite	15-23	NFE2 like bZIP transcription factor 2	Homo sapiens	36-40
26291278-8	2015	In response to arsenite, binding of Nrf2 to the HO-1 ARE preceded phosphorylation of H3S10 at the HO-1 ARE.	arsenite	15-23	heme oxygenase 1	Homo sapiens	48-52
26291278-8	2015	In response to arsenite, binding of Nrf2 to the HO-1 ARE preceded phosphorylation of H3S10 at the HO-1 ARE.	arsenite	15-23	heme oxygenase 1	Homo sapiens	98-102
26291278-9	2015	Furthermore, arsenite-mediated occupancy of phosphorylated H3S10 at the HO-1 ARE was decreased in Nrf2-deficient mouse embryonic fibroblasts.	arsenite	13-21	heme oxygenase 1	Homo sapiens	72-76
26291278-0	2015	Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme oxygenase-1 gene.	arsenite	75-83	heme oxygenase 1	Homo sapiens	121-137
26291278-4	2015	The environmental contaminant arsenite is a potent inducer of both HO-1 expression and phosphorylation of histone H3 serine 10 (H3S10); therefore, we investigated the relationships between Nrf2 and H3S10 phosphorylation in arsenite-induced, ARE-dependent, transcriptional activation of the human HO-1 gene.	arsenite	30-38	heme oxygenase 1	Homo sapiens	67-71
26291278-4	2015	The environmental contaminant arsenite is a potent inducer of both HO-1 expression and phosphorylation of histone H3 serine 10 (H3S10); therefore, we investigated the relationships between Nrf2 and H3S10 phosphorylation in arsenite-induced, ARE-dependent, transcriptional activation of the human HO-1 gene.	arsenite	30-38	NFE2 like bZIP transcription factor 2	Homo sapiens	189-193
26291278-4	2015	The environmental contaminant arsenite is a potent inducer of both HO-1 expression and phosphorylation of histone H3 serine 10 (H3S10); therefore, we investigated the relationships between Nrf2 and H3S10 phosphorylation in arsenite-induced, ARE-dependent, transcriptional activation of the human HO-1 gene.	arsenite	30-38	heme oxygenase 1	Homo sapiens	296-300
26291278-9	2015	Furthermore, arsenite-mediated occupancy of phosphorylated H3S10 at the HO-1 ARE was decreased in Nrf2-deficient mouse embryonic fibroblasts.	arsenite	13-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	98-102
26291278-5	2015	Arsenite increased phosphorylation of H3S10 both globally and at the HO-1 promoter concomitantly with HO-1 transcription in human HaCaT keratinocytes.	arsenite	0-8	heme oxygenase 1	Homo sapiens	69-73
26291278-11	2015	Our data highlights the complex interplay between Nrf2 and H3S10 phosphorylation in arsenite-activated HO-1 transcription.	arsenite	84-92	NFE2 like bZIP transcription factor 2	Homo sapiens	50-54
26291278-6	2015	Conversely, arsenite-induced H3S10 phosphorylation and HO-1 expression were blocked by N-acetylcysteine (NAC), the c-Jun N-terminal kinase (JNK) inhibitor SP600125, and JNK knockdown (siJNK).	arsenite	12-20	heme oxygenase 1	Homo sapiens	55-59
26291278-11	2015	Our data highlights the complex interplay between Nrf2 and H3S10 phosphorylation in arsenite-activated HO-1 transcription.	arsenite	84-92	heme oxygenase 1	Homo sapiens	103-107
26291278-6	2015	Conversely, arsenite-induced H3S10 phosphorylation and HO-1 expression were blocked by N-acetylcysteine (NAC), the c-Jun N-terminal kinase (JNK) inhibitor SP600125, and JNK knockdown (siJNK).	arsenite	12-20	mitogen-activated protein kinase 8	Homo sapiens	115-138
26291278-6	2015	Conversely, arsenite-induced H3S10 phosphorylation and HO-1 expression were blocked by N-acetylcysteine (NAC), the c-Jun N-terminal kinase (JNK) inhibitor SP600125, and JNK knockdown (siJNK).	arsenite	12-20	mitogen-activated protein kinase 8	Homo sapiens	140-143
26291278-6	2015	Conversely, arsenite-induced H3S10 phosphorylation and HO-1 expression were blocked by N-acetylcysteine (NAC), the c-Jun N-terminal kinase (JNK) inhibitor SP600125, and JNK knockdown (siJNK).	arsenite	12-20	mitogen-activated protein kinase 8	Homo sapiens	169-172
26063592-5	2015	Because 3-methyladenine (an autophagic inhibitor) attenuated the arsenite-reduced alpha-synuclein levels (a protein essential for the neurite outgrowth and synaptic plasticity), melatonin via inhibiting autophagy attenuated the arsenite-reduced alpha-synuclein levels.	arsenite	65-73	synuclein alpha	Rattus norvegicus	82-97
26063592-5	2015	Because 3-methyladenine (an autophagic inhibitor) attenuated the arsenite-reduced alpha-synuclein levels (a protein essential for the neurite outgrowth and synaptic plasticity), melatonin via inhibiting autophagy attenuated the arsenite-reduced alpha-synuclein levels.	arsenite	65-73	synuclein alpha	Rattus norvegicus	245-260
26063592-6	2015	At the same time, melatonin ameliorated the arsenite-induced reduction in growth associated protein 43 (a hallmark protein of neurite outgrowth) and discontinuous neurites of rat primary cultured cortical neurons.	arsenite	44-52	growth associated protein 43	Rattus norvegicus	74-102
26063592-8	2015	Moreover, melatonin prevented arsenite-induced reduction in peroxisome proliferator-activated receptor gamma co-activator 1 alpha, a transcriptional co-activator of mitochondrial biosynthesis.	arsenite	30-38	PPARG coactivator 1 alpha	Rattus norvegicus	60-129
24912785-3	2015	The present research aimed to determine whether miRNAs secreted from human bronchial epithelial (HBE) cells transformed by 1.0 muM arsenite are transferred into normal HBE cells and are functionally active in the recipient cells.	arsenite	131-139	latexin	Homo sapiens	127-130
26422469-10	2015	We performed a detailed comparison of the two arsenic-related islands found in CB2, carrying the genes required for arsenite oxidation and As resistance, with those found in K12, 3As, and five other Thiomonas strains also isolated from Carnoules (CB1, CB3, CB6, ACO3 and ACO7).	arsenite	116-124	cannabinoid receptor 2	Homo sapiens	79-82
26101800-0	2015	The IL-6/STAT3 pathway via miR-21 is involved in the neoplastic and metastatic properties of arsenite-transformed human keratinocytes.	arsenite	93-101	interleukin 6	Homo sapiens	4-8
26101800-0	2015	The IL-6/STAT3 pathway via miR-21 is involved in the neoplastic and metastatic properties of arsenite-transformed human keratinocytes.	arsenite	93-101	signal transducer and activator of transcription 3	Homo sapiens	9-14
26101800-0	2015	The IL-6/STAT3 pathway via miR-21 is involved in the neoplastic and metastatic properties of arsenite-transformed human keratinocytes.	arsenite	93-101	microRNA 21	Homo sapiens	27-33
26101800-4	2015	In HaCaT cells, arsenite caused increases of IL-6 and miR-21 levels and activation of STAT3, which induced the epithelial-mesenchymal transition (EMT).	arsenite	16-24	interleukin 6	Homo sapiens	45-49
26101800-4	2015	In HaCaT cells, arsenite caused increases of IL-6 and miR-21 levels and activation of STAT3, which induced the epithelial-mesenchymal transition (EMT).	arsenite	16-24	microRNA 21	Homo sapiens	54-60
26101800-4	2015	In HaCaT cells, arsenite caused increases of IL-6 and miR-21 levels and activation of STAT3, which induced the epithelial-mesenchymal transition (EMT).	arsenite	16-24	signal transducer and activator of transcription 3	Homo sapiens	86-91
26101800-7	2015	In arsenite-transformed HaCaT (HaCaT-30T) cells, down-regulation of STAT3 by siRNA blocked the process of EMT and decreased their neoplastic properties and migratory capacity, effects that were antagonized by over-expression of miR-21.Thus, the IL-6/STAT3 pathway via miR-21 is involved in EMT, neoplastic properties, and migratory capacity of arsenite-transformed HaCaT cells.	arsenite	3-11	signal transducer and activator of transcription 3	Homo sapiens	68-73
26101800-7	2015	In arsenite-transformed HaCaT (HaCaT-30T) cells, down-regulation of STAT3 by siRNA blocked the process of EMT and decreased their neoplastic properties and migratory capacity, effects that were antagonized by over-expression of miR-21.Thus, the IL-6/STAT3 pathway via miR-21 is involved in EMT, neoplastic properties, and migratory capacity of arsenite-transformed HaCaT cells.	arsenite	3-11	microRNA 21	Homo sapiens	228-234
26101800-7	2015	In arsenite-transformed HaCaT (HaCaT-30T) cells, down-regulation of STAT3 by siRNA blocked the process of EMT and decreased their neoplastic properties and migratory capacity, effects that were antagonized by over-expression of miR-21.Thus, the IL-6/STAT3 pathway via miR-21 is involved in EMT, neoplastic properties, and migratory capacity of arsenite-transformed HaCaT cells.	arsenite	3-11	interleukin 6	Homo sapiens	245-249
26101800-7	2015	In arsenite-transformed HaCaT (HaCaT-30T) cells, down-regulation of STAT3 by siRNA blocked the process of EMT and decreased their neoplastic properties and migratory capacity, effects that were antagonized by over-expression of miR-21.Thus, the IL-6/STAT3 pathway via miR-21 is involved in EMT, neoplastic properties, and migratory capacity of arsenite-transformed HaCaT cells.	arsenite	3-11	signal transducer and activator of transcription 3	Homo sapiens	250-255
26101800-7	2015	In arsenite-transformed HaCaT (HaCaT-30T) cells, down-regulation of STAT3 by siRNA blocked the process of EMT and decreased their neoplastic properties and migratory capacity, effects that were antagonized by over-expression of miR-21.Thus, the IL-6/STAT3 pathway via miR-21 is involved in EMT, neoplastic properties, and migratory capacity of arsenite-transformed HaCaT cells.	arsenite	3-11	microRNA 21	Homo sapiens	268-274
25721523-9	2015	Antimonite sensitivity correlated with the presence of ACR3(1) mainly present in Bacteroidetes and Actinobacteria, and arsenite or antimonite resistance correlated with arsB gene presence.	arsenite	119-127	arylsulfatase B	Homo sapiens	169-173
26210637-5	2015	Results indicate that MEF Ogg1(+/+) and Ogg1(-/-) cells chronically exposed to i-As repair the DNA damage induced by arsenite, potassium bromide and UVC radiation less efficiently than control cells, being that observation clearly more pronounced in MEF Ogg1(-/-) cells.	arsenite	117-125	8-oxoguanine DNA glycosylase	Homo sapiens	26-30
26210637-5	2015	Results indicate that MEF Ogg1(+/+) and Ogg1(-/-) cells chronically exposed to i-As repair the DNA damage induced by arsenite, potassium bromide and UVC radiation less efficiently than control cells, being that observation clearly more pronounced in MEF Ogg1(-/-) cells.	arsenite	117-125	8-oxoguanine DNA glycosylase	Homo sapiens	40-44
26210637-5	2015	Results indicate that MEF Ogg1(+/+) and Ogg1(-/-) cells chronically exposed to i-As repair the DNA damage induced by arsenite, potassium bromide and UVC radiation less efficiently than control cells, being that observation clearly more pronounced in MEF Ogg1(-/-) cells.	arsenite	117-125	8-oxoguanine DNA glycosylase	Homo sapiens	40-44
26260897-0	2015	The small heat shock protein, HSP30, is associated with aggresome-like inclusion bodies in proteasomal inhibitor-, arsenite-, and cadmium-treated Xenopus kidney cells.	arsenite	115-123	heat shock 70kDa protein L homeolog	Xenopus laevis	10-28
26260897-0	2015	The small heat shock protein, HSP30, is associated with aggresome-like inclusion bodies in proteasomal inhibitor-, arsenite-, and cadmium-treated Xenopus kidney cells.	arsenite	115-123	heat shock protein 30E L homeolog	Xenopus laevis	30-35
25808059-8	2015	Intriguingly, loss of PRDX-2 increases DAF-16 and SKN-1 activities sufficiently to increase arsenite resistance without initiating other IIS-inhibited processes.	arsenite	92-100	peroxiredoxin 2	Homo sapiens	22-28
26622574-7	2015	Additionally, it was found that arsenite accumulation in the PC-9 cell line was affected through the downregulation of GS-X pump systems.	arsenite	32-40	proprotein convertase subtilisin/kexin type 9	Homo sapiens	61-65
26622574-7	2015	Additionally, it was found that arsenite accumulation in the PC-9 cell line was affected through the downregulation of GS-X pump systems.	arsenite	32-40	ATP binding cassette subfamily C member 1	Homo sapiens	119-123
25493652-5	2015	The arsenite-mediated promotion of anchorage-independent growth was strongly inhibited by PlGF depletion with decreased activities of the PlGF/VEGFR1/MEK/ERK pathway.	arsenite	4-12	placental growth factor	Homo sapiens	138-142
26044777-11	2015	Arsenite (150 ppm As) and arsenate (100 ppm As) inhibited hepatic HMG CoA reductase.	arsenite	0-8	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	66-83
25701757-0	2015	Disruption of polyubiquitin gene Ubc leads to attenuated resistance against arsenite-induced toxicity in mouse embryonic fibroblasts.	arsenite	76-84	ubiquitin C	Mus musculus	33-36
25701757-1	2015	The polyubiquitin gene Ubc is upregulated under oxidative stress induced by arsenite [As(III)].	arsenite	76-84	ubiquitin C	Mus musculus	23-26
25732589-0	2015	Arabidopsis NIP3;1 Plays an Important Role in Arsenic Uptake and Root-to-Shoot Translocation under Arsenite Stress Conditions.	arsenite	99-107	NOD26-like intrinsic protein 3;1	Arabidopsis thaliana	12-18
25732589-3	2015	In this study, using reverse genetic strategies, Arabidopsis NIP3;1 was identified to play an important role in both the arsenic uptake and root-to-shoot distribution under arsenite stress conditions.	arsenite	173-181	NOD26-like intrinsic protein 3;1	Arabidopsis thaliana	61-67
25732589-4	2015	The nip3;1 loss-of-function mutants displayed obvious improvements in arsenite tolerance for aboveground growth and accumulated less arsenic in shoots than those of the wild-type plants, whereas the nip3;1 nip1;1 double mutant showed strong arsenite tolerance and improved growth of both roots and shoots under arsenite stress conditions.	arsenite	70-78	NOD26-like intrinsic protein 3;1	Arabidopsis thaliana	4-10
25732589-4	2015	The nip3;1 loss-of-function mutants displayed obvious improvements in arsenite tolerance for aboveground growth and accumulated less arsenic in shoots than those of the wild-type plants, whereas the nip3;1 nip1;1 double mutant showed strong arsenite tolerance and improved growth of both roots and shoots under arsenite stress conditions.	arsenite	241-249	NOD26-like intrinsic protein 3;1	Arabidopsis thaliana	4-10
25732589-4	2015	The nip3;1 loss-of-function mutants displayed obvious improvements in arsenite tolerance for aboveground growth and accumulated less arsenic in shoots than those of the wild-type plants, whereas the nip3;1 nip1;1 double mutant showed strong arsenite tolerance and improved growth of both roots and shoots under arsenite stress conditions.	arsenite	241-249	NOD26-like intrinsic protein 3;1	Arabidopsis thaliana	199-205
25732589-4	2015	The nip3;1 loss-of-function mutants displayed obvious improvements in arsenite tolerance for aboveground growth and accumulated less arsenic in shoots than those of the wild-type plants, whereas the nip3;1 nip1;1 double mutant showed strong arsenite tolerance and improved growth of both roots and shoots under arsenite stress conditions.	arsenite	241-249	NOD26-like major intrinsic protein 1	Arabidopsis thaliana	206-212
25732589-4	2015	The nip3;1 loss-of-function mutants displayed obvious improvements in arsenite tolerance for aboveground growth and accumulated less arsenic in shoots than those of the wild-type plants, whereas the nip3;1 nip1;1 double mutant showed strong arsenite tolerance and improved growth of both roots and shoots under arsenite stress conditions.	arsenite	241-249	NOD26-like intrinsic protein 3;1	Arabidopsis thaliana	4-10
25732589-4	2015	The nip3;1 loss-of-function mutants displayed obvious improvements in arsenite tolerance for aboveground growth and accumulated less arsenic in shoots than those of the wild-type plants, whereas the nip3;1 nip1;1 double mutant showed strong arsenite tolerance and improved growth of both roots and shoots under arsenite stress conditions.	arsenite	241-249	NOD26-like intrinsic protein 3;1	Arabidopsis thaliana	199-205
25732589-4	2015	The nip3;1 loss-of-function mutants displayed obvious improvements in arsenite tolerance for aboveground growth and accumulated less arsenic in shoots than those of the wild-type plants, whereas the nip3;1 nip1;1 double mutant showed strong arsenite tolerance and improved growth of both roots and shoots under arsenite stress conditions.	arsenite	241-249	NOD26-like major intrinsic protein 1	Arabidopsis thaliana	206-212
25732589-5	2015	A promoter-beta-glucuronidase analysis revealed that NIP3;1 was expressed almost exclusively in roots (with the exception of the root tips), and heterologous expression in the yeast Saccharomyces cerevisiae demonstrated that NIP3;1 was able to mediate arsenite transport.	arsenite	252-260	NOD26-like intrinsic protein 3;1	Arabidopsis thaliana	53-59
25732589-5	2015	A promoter-beta-glucuronidase analysis revealed that NIP3;1 was expressed almost exclusively in roots (with the exception of the root tips), and heterologous expression in the yeast Saccharomyces cerevisiae demonstrated that NIP3;1 was able to mediate arsenite transport.	arsenite	252-260	NOD26-like intrinsic protein 3;1	Arabidopsis thaliana	225-231
25732589-6	2015	Taken together, our results suggest that NIP3;1 is involved in arsenite uptake and root-to-shoot translocation in Arabidopsis, probably as a passive and bidirectional arsenite transporter.	arsenite	63-71	NOD26-like intrinsic protein 3;1	Arabidopsis thaliana	41-47
25788710-2	2015	The most sensitive target of arsenic toxicity in the vasculature is the endothelium, and incubation of these cells with low concentrations of arsenite, a naturally occurring and highly toxic inorganic form of arsenic, rapidly induces reactive oxygen species (ROS) formation via activation of a specific NADPH oxidase (Nox2).	arsenite	142-150	cytochrome b-245 beta chain	Homo sapiens	318-322
25788710-3	2015	Arsenite also induces ROS accumulation in vascular smooth muscle cells, but this is relatively delayed because, depending on the vessel from which they originate, these cells often lack Nox2 and/or its essential regulatory cytosolic subunits.	arsenite	0-8	cytochrome b-245 beta chain	Homo sapiens	186-190
25252218-7	2015	In HBE cells, arsenite induced increases of miR-191 and WT1 levels, decreased BASP1 expression, and activated the Wnt/beta-catenin pathway, effects that were blocked by miR-191 knockdown.	arsenite	14-22	microRNA 191	Homo sapiens	44-51
25252218-7	2015	In HBE cells, arsenite induced increases of miR-191 and WT1 levels, decreased BASP1 expression, and activated the Wnt/beta-catenin pathway, effects that were blocked by miR-191 knockdown.	arsenite	14-22	WT1 transcription factor	Homo sapiens	56-59
25252218-7	2015	In HBE cells, arsenite induced increases of miR-191 and WT1 levels, decreased BASP1 expression, and activated the Wnt/beta-catenin pathway, effects that were blocked by miR-191 knockdown.	arsenite	14-22	brain abundant membrane attached signal protein 1	Homo sapiens	78-83
25252218-7	2015	In HBE cells, arsenite induced increases of miR-191 and WT1 levels, decreased BASP1 expression, and activated the Wnt/beta-catenin pathway, effects that were blocked by miR-191 knockdown.	arsenite	14-22	catenin beta 1	Homo sapiens	118-130
25252218-7	2015	In HBE cells, arsenite induced increases of miR-191 and WT1 levels, decreased BASP1 expression, and activated the Wnt/beta-catenin pathway, effects that were blocked by miR-191 knockdown.	arsenite	14-22	microRNA 191	Homo sapiens	169-176
26137629-11	2015	CONCLUSION: Long-term exposure to low concentrations of inorganic arsenic-induced malignant transformation of HaCaT cells is accompanied by intracellular imbalance between oxidative-antioxidant, which increased expression of SOD and low levels of ROS found in the later-stage of arsenite-induced transformation.	arsenite	279-287	superoxide dismutase 1	Homo sapiens	225-228
25922308-9	2015	CONCLUSION: Our results indicate that sudden exposure of cells to arsenite (As(+3)) resulted in cytotoxicity and mitochondrial-mediated apoptosis resulting from up-regulation of caspases.	arsenite	66-74	caspase 9	Homo sapiens	178-186
24862236-4	2015	The present study has evaluated the effect of 1 microM arsenite [As(III)], 0.1 microM MMA(III) and 1 microM DMA(III) upon the release of cytokines [interleukin-6 (IL6), IL8, tumor necrosis factor alpha (TNFalpha)], using a compartmentalized co-culture model with differentiated Caco-2 cells in the apical compartment and peripheral blood mononuclear cells in the basolateral compartment.	arsenite	55-63	interleukin 6	Homo sapiens	148-161
25493652-0	2015	Arsenite-mediated promotion of anchorage-independent growth of HaCaT cells through placental growth factor.	arsenite	0-8	placental growth factor	Homo sapiens	83-106
25493652-4	2015	Our experimental study in human nontumorigenic HaCaT skin keratinocytes showed that arsenite promoted anchorage-independent growth with increased expression and secretion of PlGF, a ligand of vascular endothelial growth factor receptor1 (VEGFR1), and increased VEGFR1/mitogen-activated protein kinase/ERK kinase (MEK)/extracellular signal-regulated kinase (ERK) activities.	arsenite	84-92	placental growth factor	Homo sapiens	174-178
25493652-4	2015	Our experimental study in human nontumorigenic HaCaT skin keratinocytes showed that arsenite promoted anchorage-independent growth with increased expression and secretion of PlGF, a ligand of vascular endothelial growth factor receptor1 (VEGFR1), and increased VEGFR1/mitogen-activated protein kinase/ERK kinase (MEK)/extracellular signal-regulated kinase (ERK) activities.	arsenite	84-92	fms related receptor tyrosine kinase 1	Homo sapiens	192-236
25493652-4	2015	Our experimental study in human nontumorigenic HaCaT skin keratinocytes showed that arsenite promoted anchorage-independent growth with increased expression and secretion of PlGF, a ligand of vascular endothelial growth factor receptor1 (VEGFR1), and increased VEGFR1/mitogen-activated protein kinase/ERK kinase (MEK)/extracellular signal-regulated kinase (ERK) activities.	arsenite	84-92	fms related receptor tyrosine kinase 1	Homo sapiens	238-244
25493652-4	2015	Our experimental study in human nontumorigenic HaCaT skin keratinocytes showed that arsenite promoted anchorage-independent growth with increased expression and secretion of PlGF, a ligand of vascular endothelial growth factor receptor1 (VEGFR1), and increased VEGFR1/mitogen-activated protein kinase/ERK kinase (MEK)/extracellular signal-regulated kinase (ERK) activities.	arsenite	84-92	fms related receptor tyrosine kinase 1	Homo sapiens	261-267
25493652-4	2015	Our experimental study in human nontumorigenic HaCaT skin keratinocytes showed that arsenite promoted anchorage-independent growth with increased expression and secretion of PlGF, a ligand of vascular endothelial growth factor receptor1 (VEGFR1), and increased VEGFR1/mitogen-activated protein kinase/ERK kinase (MEK)/extracellular signal-regulated kinase (ERK) activities.	arsenite	84-92	mitogen-activated protein kinase 1	Homo sapiens	301-304
25493652-5	2015	The arsenite-mediated promotion of anchorage-independent growth was strongly inhibited by PlGF depletion with decreased activities of the PlGF/VEGFR1/MEK/ERK pathway.	arsenite	4-12	fms related receptor tyrosine kinase 1	Homo sapiens	143-149
25493652-4	2015	Our experimental study in human nontumorigenic HaCaT skin keratinocytes showed that arsenite promoted anchorage-independent growth with increased expression and secretion of PlGF, a ligand of vascular endothelial growth factor receptor1 (VEGFR1), and increased VEGFR1/mitogen-activated protein kinase/ERK kinase (MEK)/extracellular signal-regulated kinase (ERK) activities.	arsenite	84-92	mitogen-activated protein kinase kinase 7	Homo sapiens	313-316
25493652-4	2015	Our experimental study in human nontumorigenic HaCaT skin keratinocytes showed that arsenite promoted anchorage-independent growth with increased expression and secretion of PlGF, a ligand of vascular endothelial growth factor receptor1 (VEGFR1), and increased VEGFR1/mitogen-activated protein kinase/ERK kinase (MEK)/extracellular signal-regulated kinase (ERK) activities.	arsenite	84-92	mitogen-activated protein kinase 1	Homo sapiens	357-360
25493652-5	2015	The arsenite-mediated promotion of anchorage-independent growth was strongly inhibited by PlGF depletion with decreased activities of the PlGF/VEGFR1/MEK/ERK pathway.	arsenite	4-12	placental growth factor	Homo sapiens	90-94
25493652-5	2015	The arsenite-mediated promotion of anchorage-independent growth was strongly inhibited by PlGF depletion with decreased activities of the PlGF/VEGFR1/MEK/ERK pathway.	arsenite	4-12	mitogen-activated protein kinase kinase 7	Homo sapiens	150-153
25493652-5	2015	The arsenite-mediated promotion of anchorage-independent growth was strongly inhibited by PlGF depletion with decreased activities of the PlGF/VEGFR1/MEK/ERK pathway.	arsenite	4-12	mitogen-activated protein kinase 1	Homo sapiens	154-157
25493652-8	2015	These results suggest that arsenite-mediated MTF-1 degradation enhances the activity of PlGF/VEGFR1/MEK/ERK signaling, resulting in promotion of the malignant transformation of keratinocytes.	arsenite	27-35	metal regulatory transcription factor 1	Homo sapiens	45-50
25493652-8	2015	These results suggest that arsenite-mediated MTF-1 degradation enhances the activity of PlGF/VEGFR1/MEK/ERK signaling, resulting in promotion of the malignant transformation of keratinocytes.	arsenite	27-35	placental growth factor	Homo sapiens	88-92
25493652-8	2015	These results suggest that arsenite-mediated MTF-1 degradation enhances the activity of PlGF/VEGFR1/MEK/ERK signaling, resulting in promotion of the malignant transformation of keratinocytes.	arsenite	27-35	fms related receptor tyrosine kinase 1	Homo sapiens	93-99
25493652-8	2015	These results suggest that arsenite-mediated MTF-1 degradation enhances the activity of PlGF/VEGFR1/MEK/ERK signaling, resulting in promotion of the malignant transformation of keratinocytes.	arsenite	27-35	mitogen-activated protein kinase kinase 7	Homo sapiens	100-103
25493652-8	2015	These results suggest that arsenite-mediated MTF-1 degradation enhances the activity of PlGF/VEGFR1/MEK/ERK signaling, resulting in promotion of the malignant transformation of keratinocytes.	arsenite	27-35	mitogen-activated protein kinase 1	Homo sapiens	104-107
25517993-6	2015	We provide biochemical evidence that GstB acts to directly reduce arsenate to arsenite with reduced glutathione (GSH) as the electron donor.	arsenite	78-86	glutathione S-transferase mu 3	Homo sapiens	37-41
25923732-3	2015	Using immortalized and cancer cell lines, retroviral expression of a phosphomimetic (S209D) form of eIF4E, but not phospho-dead (S209A) eIF4E or GFP control, significantly increased cellular resistance to stress induced by DNA-damaging agents (cisplatin), starvation (glucose+glutamine withdrawal), and oxidative stress (arsenite).	arsenite	321-329	eukaryotic translation initiation factor 4E	Mus musculus	100-105
25923732-5	2015	Increased resistance to cellular stress induced by eIF4E-S209D was lost upon knockdown of endogenous 4E-T or use of an eIF4E-W73A-S209D mutant unable to bind 4E-T. Cancer cells treated with the Mnk1/2 inhibitor CGP57380 to prevent eIF4E phosphorylation and mouse embryonic fibroblasts derived from Mnk1/2 knockout mice were also more sensitive to arsenite and cisplatin treatment.	arsenite	347-355	eukaryotic translation initiation factor 4E	Mus musculus	51-56
25923732-5	2015	Increased resistance to cellular stress induced by eIF4E-S209D was lost upon knockdown of endogenous 4E-T or use of an eIF4E-W73A-S209D mutant unable to bind 4E-T. Cancer cells treated with the Mnk1/2 inhibitor CGP57380 to prevent eIF4E phosphorylation and mouse embryonic fibroblasts derived from Mnk1/2 knockout mice were also more sensitive to arsenite and cisplatin treatment.	arsenite	347-355	eukaryotic translation initiation factor 4E	Mus musculus	119-124
25923732-5	2015	Increased resistance to cellular stress induced by eIF4E-S209D was lost upon knockdown of endogenous 4E-T or use of an eIF4E-W73A-S209D mutant unable to bind 4E-T. Cancer cells treated with the Mnk1/2 inhibitor CGP57380 to prevent eIF4E phosphorylation and mouse embryonic fibroblasts derived from Mnk1/2 knockout mice were also more sensitive to arsenite and cisplatin treatment.	arsenite	347-355	eukaryotic translation initiation factor 4E	Mus musculus	119-124
25923732-6	2015	Polysome analysis revealed an 80S peak 2 hours after arsenite treatment in cells overexpressing phosphomimetic eIF4E, indicating translational stalling.	arsenite	53-61	eukaryotic translation initiation factor 4E	Mus musculus	111-116
25639566-4	2015	Incubation of 3-methyladenine (an autophagy inhibitor) prevented arsenite-induced LC3-II elevation, autolysosome formation, reduction in GAP 43 (a biomarker of neurite outgrowth), caspase 3 activation and neuronal cell loss.	arsenite	65-73	growth associated protein 43	Rattus norvegicus	137-143
25639566-4	2015	Incubation of 3-methyladenine (an autophagy inhibitor) prevented arsenite-induced LC3-II elevation, autolysosome formation, reduction in GAP 43 (a biomarker of neurite outgrowth), caspase 3 activation and neuronal cell loss.	arsenite	65-73	caspase 3	Rattus norvegicus	180-189
25639566-5	2015	Furthermore, Atg7 siRNA transfection attenuated arsenite-induced autophagy and neurotoxicity.	arsenite	48-56	autophagy related 7	Rattus norvegicus	13-17
25639566-6	2015	At the same time, Atg7siRNA transfection ameliorated arsenite-induced reduction in alpha-synuclein levels (a synaptic protein essential for neuroplasticity), suggesting that arsenite via autophagy may engulf alpha-synuclein.	arsenite	53-61	autophagy related 7	Rattus norvegicus	18-22
25639566-6	2015	At the same time, Atg7siRNA transfection ameliorated arsenite-induced reduction in alpha-synuclein levels (a synaptic protein essential for neuroplasticity), suggesting that arsenite via autophagy may engulf alpha-synuclein.	arsenite	53-61	synuclein alpha	Rattus norvegicus	83-98
25639566-6	2015	At the same time, Atg7siRNA transfection ameliorated arsenite-induced reduction in alpha-synuclein levels (a synaptic protein essential for neuroplasticity), suggesting that arsenite via autophagy may engulf alpha-synuclein.	arsenite	53-61	synuclein alpha	Rattus norvegicus	208-223
25639566-6	2015	At the same time, Atg7siRNA transfection ameliorated arsenite-induced reduction in alpha-synuclein levels (a synaptic protein essential for neuroplasticity), suggesting that arsenite via autophagy may engulf alpha-synuclein.	arsenite	174-182	autophagy related 7	Rattus norvegicus	18-22
25639566-6	2015	At the same time, Atg7siRNA transfection ameliorated arsenite-induced reduction in alpha-synuclein levels (a synaptic protein essential for neuroplasticity), suggesting that arsenite via autophagy may engulf alpha-synuclein.	arsenite	174-182	synuclein alpha	Rattus norvegicus	83-98
25639566-6	2015	At the same time, Atg7siRNA transfection ameliorated arsenite-induced reduction in alpha-synuclein levels (a synaptic protein essential for neuroplasticity), suggesting that arsenite via autophagy may engulf alpha-synuclein.	arsenite	174-182	synuclein alpha	Rattus norvegicus	208-223
25639566-7	2015	Cytotoxic activities as well as potencies in elevating LC3-II and reducing alpha-synuclein levels by arsenite, arsenate, monomethyl arsenite (MMA(III)), and dimethyl arsenate (DMA(V)) were compared as follows: MMA(III)>arsenite>>arsenate and DMA(V).	arsenite	101-109	synuclein alpha	Rattus norvegicus	75-90
25639566-7	2015	Cytotoxic activities as well as potencies in elevating LC3-II and reducing alpha-synuclein levels by arsenite, arsenate, monomethyl arsenite (MMA(III)), and dimethyl arsenate (DMA(V)) were compared as follows: MMA(III)>arsenite>>arsenate and DMA(V).	arsenite	132-140	synuclein alpha	Rattus norvegicus	75-90
25310083-3	2014	Pretreatment with 20 mM NAC prior to arsenite exposure suppressed apoptosis up to 75% in the monocytes and 100% in the macrophages.	arsenite	37-45	X-linked Kx blood group	Homo sapiens	24-27
25561743-0	2015	A novel post-translational modification of nucleolin, SUMOylation at Lys-294, mediates arsenite-induced cell death by regulating gadd45alpha mRNA stability.	arsenite	87-95	nucleolin	Homo sapiens	43-52
25561743-0	2015	A novel post-translational modification of nucleolin, SUMOylation at Lys-294, mediates arsenite-induced cell death by regulating gadd45alpha mRNA stability.	arsenite	87-95	growth arrest and DNA damage inducible alpha	Homo sapiens	129-140
25561743-6	2015	On the other hand, ectopic expression of Mn-SOD attenuated the arsenite-generated superoxide radical level, abrogated nucleolin-SUMO, and in turn inhibited arsenite-induced apoptosis by reducing GADD45alpha expression.	arsenite	63-71	superoxide dismutase 2	Homo sapiens	41-47
25561743-6	2015	On the other hand, ectopic expression of Mn-SOD attenuated the arsenite-generated superoxide radical level, abrogated nucleolin-SUMO, and in turn inhibited arsenite-induced apoptosis by reducing GADD45alpha expression.	arsenite	156-164	superoxide dismutase 2	Homo sapiens	41-47
25561743-6	2015	On the other hand, ectopic expression of Mn-SOD attenuated the arsenite-generated superoxide radical level, abrogated nucleolin-SUMO, and in turn inhibited arsenite-induced apoptosis by reducing GADD45alpha expression.	arsenite	156-164	growth arrest and DNA damage inducible alpha	Homo sapiens	195-206
25445583-6	2015	In addition, PDCD4 interacted with Twist1 and inhibited its expression function, which is involved in arsenite-induced EMT.	arsenite	102-110	programmed cell death 4	Homo sapiens	13-18
25445583-6	2015	In addition, PDCD4 interacted with Twist1 and inhibited its expression function, which is involved in arsenite-induced EMT.	arsenite	102-110	twist family bHLH transcription factor 1	Homo sapiens	35-41
25445583-7	2015	Thus, miR-21, acting on PDCD4, which interacts with Twist1 and represses the expression of Twist1, contributes to the EMT induced by arsenite.	arsenite	133-141	microRNA 21	Homo sapiens	6-12
25445583-7	2015	Thus, miR-21, acting on PDCD4, which interacts with Twist1 and represses the expression of Twist1, contributes to the EMT induced by arsenite.	arsenite	133-141	programmed cell death 4	Homo sapiens	24-29
25445583-7	2015	Thus, miR-21, acting on PDCD4, which interacts with Twist1 and represses the expression of Twist1, contributes to the EMT induced by arsenite.	arsenite	133-141	twist family bHLH transcription factor 1	Homo sapiens	52-58
25445583-7	2015	Thus, miR-21, acting on PDCD4, which interacts with Twist1 and represses the expression of Twist1, contributes to the EMT induced by arsenite.	arsenite	133-141	twist family bHLH transcription factor 1	Homo sapiens	91-97
25704077-2	2015	Earlier, we reported that ATF5 expression is up-regulated in response to stress, such as amino acid limitation or arsenite exposure.	arsenite	114-122	activating transcription factor 5	Mus musculus	26-30
26160017-0	2015	Neuroglobin Plays a Protective Role in Arsenite-Induced Cytotoxicity by Inhibition of Cdc42 and Rac1GTPases in Rat Cerebellar Granule Neurons.	arsenite	39-47	neuroglobin	Rattus norvegicus	0-11
26160017-0	2015	Neuroglobin Plays a Protective Role in Arsenite-Induced Cytotoxicity by Inhibition of Cdc42 and Rac1GTPases in Rat Cerebellar Granule Neurons.	arsenite	39-47	cell division cycle 42	Rattus norvegicus	86-91
25809564-1	2015	Arsenite directly triggers cytochrome c and Smac/DIABLO release in mitochondria isolated from U937 cells.	arsenite	0-8	cytochrome c, somatic	Homo sapiens	27-39
25809564-1	2015	Arsenite directly triggers cytochrome c and Smac/DIABLO release in mitochondria isolated from U937 cells.	arsenite	0-8	diablo IAP-binding mitochondrial protein	Homo sapiens	44-48
28349811-9	2015	Conclusion Our results indicate that sudden exposure of cells to arsenite (As+3) resulted in cytotoxicity and mitochondrial-mediated apoptosis resulting from up-regulation of caspases.	arsenite	65-73	caspase 9	Homo sapiens	175-183
26042454-2	2015	Arsenite alters the expression of aryl hydrocarbon receptor (AhR)-regulated genes in extrahepatic tissues; yet, the effect of organic arsenicals still unknown.	arsenite	0-8	aryl-hydrocarbon receptor	Mus musculus	34-59
26042454-2	2015	Arsenite alters the expression of aryl hydrocarbon receptor (AhR)-regulated genes in extrahepatic tissues; yet, the effect of organic arsenicals still unknown.	arsenite	0-8	aryl-hydrocarbon receptor	Mus musculus	61-64
25513814-3	2014	Hypoxia inducible factor-1 alpha (HIF-1A) is a key regulator of energy metabolism, and it has been found to accumulate during arsenite exposure under oxygen-replete conditions.	arsenite	126-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
25513814-3	2014	Hypoxia inducible factor-1 alpha (HIF-1A) is a key regulator of energy metabolism, and it has been found to accumulate during arsenite exposure under oxygen-replete conditions.	arsenite	126-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-40
25513814-6	2014	This arsenite exposure resulted in HIF-1A accumulation and increased glycolysis, similar to the physiologic response to hypoxia, but in this case under oxygen-replete conditions.	arsenite	5-13	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-41
25513814-8	2014	The HIF-1A accumulation and induction in glycolysis was sustained throughout a 52 week course of arsenite exposure in BEAS-2B.	arsenite	97-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	4-10
25513814-10	2014	When HIF-1A expression was stably suppressed, arsenite-induced glycolysis was abrogated, and the anchorage-independent growth was reduced.	arsenite	46-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	5-11
25448440-6	2014	We found that arsenite exposure significantly reduced transcript levels of genes in the Shh pathway in both a time and dose-dependent manner.	arsenite	14-22	sonic hedgehog signaling molecule	Homo sapiens	88-91
25446091-0	2014	Arsenite inhibits mRNA deadenylation through proteolytic degradation of Tob and Pan3.	arsenite	0-8	transducer of ERBB2, 1	Homo sapiens	72-75
25446091-0	2014	Arsenite inhibits mRNA deadenylation through proteolytic degradation of Tob and Pan3.	arsenite	0-8	poly(A) specific ribonuclease subunit PAN3	Homo sapiens	80-84
25446091-4	2014	Here, we show that arsenite-induced oxidative stress inhibits deadenylation of mRNA primarily through downregulation of Tob and Pan3, both of which mediate the recruitment of deadenylases to mRNA.	arsenite	19-27	transducer of ERBB2, 1	Homo sapiens	120-123
25446091-4	2014	Here, we show that arsenite-induced oxidative stress inhibits deadenylation of mRNA primarily through downregulation of Tob and Pan3, both of which mediate the recruitment of deadenylases to mRNA.	arsenite	19-27	poly(A) specific ribonuclease subunit PAN3	Homo sapiens	128-132
25446091-5	2014	Arsenite selectively induces the proteolytic degradation of Tob and Pan3, and siRNA-mediated knockdown of Tob and Pan3 recapitulates stabilization of the mRNA poly(A) tail observed during arsenite stress.	arsenite	0-8	transducer of ERBB2, 1	Homo sapiens	60-63
25446091-5	2014	Arsenite selectively induces the proteolytic degradation of Tob and Pan3, and siRNA-mediated knockdown of Tob and Pan3 recapitulates stabilization of the mRNA poly(A) tail observed during arsenite stress.	arsenite	0-8	poly(A) specific ribonuclease subunit PAN3	Homo sapiens	68-72
25446091-5	2014	Arsenite selectively induces the proteolytic degradation of Tob and Pan3, and siRNA-mediated knockdown of Tob and Pan3 recapitulates stabilization of the mRNA poly(A) tail observed during arsenite stress.	arsenite	188-196	transducer of ERBB2, 1	Homo sapiens	106-109
25446091-5	2014	Arsenite selectively induces the proteolytic degradation of Tob and Pan3, and siRNA-mediated knockdown of Tob and Pan3 recapitulates stabilization of the mRNA poly(A) tail observed during arsenite stress.	arsenite	188-196	poly(A) specific ribonuclease subunit PAN3	Homo sapiens	114-118
25310083-1	2014	In the present study, in order to clarify the preventive mechanism of N-acetyl-L-cysteine (NAC) on arsenite-induced apoptosis in U937 cells, which lack functional p53, the cytotoxicity among U937 cells [monocytes and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated macrophages] receiving NAC treatment at different times post arsenite treatment was examined.	arsenite	99-107	X-linked Kx blood group	Homo sapiens	91-94
25310083-1	2014	In the present study, in order to clarify the preventive mechanism of N-acetyl-L-cysteine (NAC) on arsenite-induced apoptosis in U937 cells, which lack functional p53, the cytotoxicity among U937 cells [monocytes and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated macrophages] receiving NAC treatment at different times post arsenite treatment was examined.	arsenite	329-337	X-linked Kx blood group	Homo sapiens	91-94
25310083-2	2014	TPA-treated macrophages were more resistant to arsenite-induced apoptosis than monocytes, which may be associated with the induction of Bcl-2 expression.	arsenite	47-55	BCL2 apoptosis regulator	Homo sapiens	136-141
25310083-5	2014	Post-treatment by NAC up to 1 h following arsenite exposure almost completely inhibited the cytotoxic effects of arsenite in U937 monocytes and macrophages.	arsenite	42-50	X-linked Kx blood group	Homo sapiens	18-21
25310083-5	2014	Post-treatment by NAC up to 1 h following arsenite exposure almost completely inhibited the cytotoxic effects of arsenite in U937 monocytes and macrophages.	arsenite	113-121	X-linked Kx blood group	Homo sapiens	18-21
25310083-6	2014	The results of the current study indicate that the preventive mechanism of NAC on arsenite-induced apoptosis in U937 monocytes and macrophages mainly involves chelation of arsenite in culture medium.	arsenite	82-90	X-linked Kx blood group	Homo sapiens	75-78
25310083-6	2014	The results of the current study indicate that the preventive mechanism of NAC on arsenite-induced apoptosis in U937 monocytes and macrophages mainly involves chelation of arsenite in culture medium.	arsenite	172-180	X-linked Kx blood group	Homo sapiens	75-78
25281835-5	2014	Acetylation of histone H4 at lysine 16 (H4K16) increased in keratinocytes exposed to 0.5muM arsenite [As(III)]; and this was associated with chromatin remodelling at the miR-34a promoter.	arsenite	92-100	microRNA 34a	Homo sapiens	170-177
25452698-6	2014	Gene neighborhood analysis of the arsenic resistance operon in the genome of Bacteroides thetaiotaomicron VPI-5482, a human gut symbiont, revealed the adjacent arrangement of genes for arsenite binding/transfer (ArsD) and cytochrome c biosynthesis (DsbD_2).	arsenite	185-193	arylsulfatase D	Homo sapiens	212-216
25412313-3	2014	Our findings showed that depletion of p27 expression by knockout and knockdown approaches efficiently enhanced S6 phosphorylation in arsenite response via overactivating Ras/Raf/MEK/ERK pathway, which consequently resulted in the stimulation of p90RSK (90 kDa ribosomal S6 kinase), a direct kinase for S6 phosphorylation.	arsenite	133-141	interferon alpha inducible protein 27	Homo sapiens	38-41
25412313-3	2014	Our findings showed that depletion of p27 expression by knockout and knockdown approaches efficiently enhanced S6 phosphorylation in arsenite response via overactivating Ras/Raf/MEK/ERK pathway, which consequently resulted in the stimulation of p90RSK (90 kDa ribosomal S6 kinase), a direct kinase for S6 phosphorylation.	arsenite	133-141	zinc fingers and homeoboxes 2	Homo sapiens	174-177
25412313-3	2014	Our findings showed that depletion of p27 expression by knockout and knockdown approaches efficiently enhanced S6 phosphorylation in arsenite response via overactivating Ras/Raf/MEK/ERK pathway, which consequently resulted in the stimulation of p90RSK (90 kDa ribosomal S6 kinase), a direct kinase for S6 phosphorylation.	arsenite	133-141	mitogen-activated protein kinase kinase 7	Homo sapiens	178-181
25412313-3	2014	Our findings showed that depletion of p27 expression by knockout and knockdown approaches efficiently enhanced S6 phosphorylation in arsenite response via overactivating Ras/Raf/MEK/ERK pathway, which consequently resulted in the stimulation of p90RSK (90 kDa ribosomal S6 kinase), a direct kinase for S6 phosphorylation.	arsenite	133-141	mitogen-activated protein kinase 1	Homo sapiens	182-185
25412313-3	2014	Our findings showed that depletion of p27 expression by knockout and knockdown approaches efficiently enhanced S6 phosphorylation in arsenite response via overactivating Ras/Raf/MEK/ERK pathway, which consequently resulted in the stimulation of p90RSK (90 kDa ribosomal S6 kinase), a direct kinase for S6 phosphorylation.	arsenite	133-141	ribosomal protein S6 kinase A1	Homo sapiens	245-251
25412313-6	2014	Mechanistic investigations showed that HIF-1alpha translation was upregulated in p27-deficient cells in an S6 phosphorylation-dependent manner and functioned as a driving force in arsenite-induced cell transformation.	arsenite	180-188	hypoxia inducible factor 1 subunit alpha	Homo sapiens	39-49
25412313-6	2014	Mechanistic investigations showed that HIF-1alpha translation was upregulated in p27-deficient cells in an S6 phosphorylation-dependent manner and functioned as a driving force in arsenite-induced cell transformation.	arsenite	180-188	interferon alpha inducible protein 27	Homo sapiens	81-84
25412313-7	2014	Knockdown of HIF-1alpha efficiently reversed arsenite-induced cell transformation in p27-depleted cells.	arsenite	45-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-23
25412313-7	2014	Knockdown of HIF-1alpha efficiently reversed arsenite-induced cell transformation in p27-depleted cells.	arsenite	45-53	interferon alpha inducible protein 27	Homo sapiens	85-88
25412313-8	2014	Taken together, our findings provided strong evidence showing that by targeting Ras/ERK pathway, p27 provided a negative control over HIF-1alpha protein synthesis in an S6-dependent manner, and abrogated arsenite-induced cell transformation via downregulation of HIF-1alpha translation.	arsenite	204-212	mitogen-activated protein kinase 1	Homo sapiens	84-87
25412313-8	2014	Taken together, our findings provided strong evidence showing that by targeting Ras/ERK pathway, p27 provided a negative control over HIF-1alpha protein synthesis in an S6-dependent manner, and abrogated arsenite-induced cell transformation via downregulation of HIF-1alpha translation.	arsenite	204-212	interferon alpha inducible protein 27	Homo sapiens	97-100
25412313-8	2014	Taken together, our findings provided strong evidence showing that by targeting Ras/ERK pathway, p27 provided a negative control over HIF-1alpha protein synthesis in an S6-dependent manner, and abrogated arsenite-induced cell transformation via downregulation of HIF-1alpha translation.	arsenite	204-212	hypoxia inducible factor 1 subunit alpha	Homo sapiens	263-273
24499675-0	2014	Arsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells.	arsenite	0-8	tumor protein p53	Homo sapiens	42-45
25489418-9	2014	Overall, our study demonstrates firstly that arsenite acutely decreases NO production at least in part by increasing eNOS-Thr(497) phosphorylation via ROS-PP1 signaling pathway, which provide the molecular mechanism underlying arsenite-induced increase in vascular disease.	arsenite	45-53	nitric oxide synthase 3	Bos taurus	117-121
25489418-9	2014	Overall, our study demonstrates firstly that arsenite acutely decreases NO production at least in part by increasing eNOS-Thr(497) phosphorylation via ROS-PP1 signaling pathway, which provide the molecular mechanism underlying arsenite-induced increase in vascular disease.	arsenite	227-235	nitric oxide synthase 3	Bos taurus	117-121
25286945-3	2014	Arsenic(III) S-adenosylmethionine methyltransferases (AS3MT in animals and ArsM in microbes) are key enzymes of arsenic biotransformation, catalyzing the methylation of inorganic arsenite to give methyl, dimethyl and trimethyl products.	arsenite	179-187	arsenite methyltransferase	Homo sapiens	54-59
24934751-0	2014	AP-1 activation attenuates the arsenite-induced apoptotic response in human bronchial epithelial cells by up-regulating HO-1 expression.	arsenite	31-39	heme oxygenase 1	Homo sapiens	120-124
24934751-4	2014	Here, we show that a significant induction of HO-1 expression is present in human bronchial epithelial cells (Beas-2B) treated with lethal doses of arsenite treatment.	arsenite	148-156	heme oxygenase 1	Homo sapiens	46-50
24934751-6	2014	As expected, HO-1 RNAi knockdown, or ERK/AP1 inhibition, renders the Beas-2B cells more sensitive to arsenite damage.	arsenite	101-109	heme oxygenase 1	Homo sapiens	13-17
24934751-6	2014	As expected, HO-1 RNAi knockdown, or ERK/AP1 inhibition, renders the Beas-2B cells more sensitive to arsenite damage.	arsenite	101-109	mitogen-activated protein kinase 1	Homo sapiens	37-40
24934751-7	2014	Our data thus suggest that transcriptional upregulation of HO-1 expression via a putative ERK/AP-1 pathway constitutes an inherent mechanism by which arsenite-induced apoptosis is attenuated.	arsenite	150-158	heme oxygenase 1	Homo sapiens	59-63
24934751-7	2014	Our data thus suggest that transcriptional upregulation of HO-1 expression via a putative ERK/AP-1 pathway constitutes an inherent mechanism by which arsenite-induced apoptosis is attenuated.	arsenite	150-158	mitogen-activated protein kinase 1	Homo sapiens	90-93
25048913-2	2014	By using the nematode Caenorhabditis elegans as an in vivo model, we found that insulin-like growth factor-1 networks and their target protein DAF-16/FOXO, known as key regulators of energy metabolism and growth, played important roles in arsenite-induced apoptosis.	arsenite	239-247	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	143-149
25048913-3	2014	Inactivation of DAF-2, AGE-1 and AKT-1 caused worms more susceptible to arsenite-induced apoptosis, which could be attenuated by DAF-16 knockout.	arsenite	72-80	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	16-21
25048913-3	2014	Inactivation of DAF-2, AGE-1 and AKT-1 caused worms more susceptible to arsenite-induced apoptosis, which could be attenuated by DAF-16 knockout.	arsenite	72-80	Phosphatidylinositol 3-kinase age-1	Caenorhabditis elegans	23-28
25048913-3	2014	Inactivation of DAF-2, AGE-1 and AKT-1 caused worms more susceptible to arsenite-induced apoptosis, which could be attenuated by DAF-16 knockout.	arsenite	72-80	Serine/threonine-protein kinase akt-1	Caenorhabditis elegans	33-38
25048913-3	2014	Inactivation of DAF-2, AGE-1 and AKT-1 caused worms more susceptible to arsenite-induced apoptosis, which could be attenuated by DAF-16 knockout.	arsenite	72-80	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	129-135
25048913-5	2014	Our results demonstrated that DAF-2/IGF-1R, AGE-1/PI3K, PDK-1/PDK1 and AKT-1/PKB negatively regulated the arsenite-induced apoptosis, whereas AKT-2 and SGK-1 acted proapoptotically.	arsenite	106-114	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	30-35
25048913-5	2014	Our results demonstrated that DAF-2/IGF-1R, AGE-1/PI3K, PDK-1/PDK1 and AKT-1/PKB negatively regulated the arsenite-induced apoptosis, whereas AKT-2 and SGK-1 acted proapoptotically.	arsenite	106-114	Phosphatidylinositol 3-kinase age-1	Caenorhabditis elegans	44-49
25048913-5	2014	Our results demonstrated that DAF-2/IGF-1R, AGE-1/PI3K, PDK-1/PDK1 and AKT-1/PKB negatively regulated the arsenite-induced apoptosis, whereas AKT-2 and SGK-1 acted proapoptotically.	arsenite	106-114	3-phosphoinositide-dependent protein kinase 1	Caenorhabditis elegans	56-61
25048913-5	2014	Our results demonstrated that DAF-2/IGF-1R, AGE-1/PI3K, PDK-1/PDK1 and AKT-1/PKB negatively regulated the arsenite-induced apoptosis, whereas AKT-2 and SGK-1 acted proapoptotically.	arsenite	106-114	3-phosphoinositide-dependent protein kinase 1	Caenorhabditis elegans	62-66
25048913-5	2014	Our results demonstrated that DAF-2/IGF-1R, AGE-1/PI3K, PDK-1/PDK1 and AKT-1/PKB negatively regulated the arsenite-induced apoptosis, whereas AKT-2 and SGK-1 acted proapoptotically.	arsenite	106-114	Serine/threonine-protein kinase akt-1	Caenorhabditis elegans	71-76
25048913-5	2014	Our results demonstrated that DAF-2/IGF-1R, AGE-1/PI3K, PDK-1/PDK1 and AKT-1/PKB negatively regulated the arsenite-induced apoptosis, whereas AKT-2 and SGK-1 acted proapoptotically.	arsenite	106-114	Serine/threonine-protein kinase akt-2	Caenorhabditis elegans	142-147
25048913-5	2014	Our results demonstrated that DAF-2/IGF-1R, AGE-1/PI3K, PDK-1/PDK1 and AKT-1/PKB negatively regulated the arsenite-induced apoptosis, whereas AKT-2 and SGK-1 acted proapoptotically.	arsenite	106-114	Serine/threonine-protein kinase sgk-1	Caenorhabditis elegans	152-157
25048913-6	2014	DAF-16/FOXO antagonized IGF-1 signals in signaling the arsenite-induced apoptosis, and apoptosis promoted by DAF-16 inactivation was attributed to its higher sensitivity to oxidative stress.	arsenite	55-63	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	0-6
25489418-1	2014	Chronic (>24 h) exposure of arsenite, an environmental toxicant, has shown the decreased nitric oxide (NO) production in endothelial cells (EC) by decreasing endothelial NO synthase (eNOS) expression and/or its phosphorylation at serine 1179 (eNOS-Ser(1179) in bovine sequence), which is associated with increased risk of vascular diseases.	arsenite	31-39	nitric oxide synthase 3	Bos taurus	186-190
25489418-1	2014	Chronic (>24 h) exposure of arsenite, an environmental toxicant, has shown the decreased nitric oxide (NO) production in endothelial cells (EC) by decreasing endothelial NO synthase (eNOS) expression and/or its phosphorylation at serine 1179 (eNOS-Ser(1179) in bovine sequence), which is associated with increased risk of vascular diseases.	arsenite	31-39	nitric oxide synthase 3	Bos taurus	246-250
25489418-3	2014	Arsenite acutely increased the phosphorylation of eNOS-Thr(497), but not of eNOS-Ser(116) or eNOS-Ser(1179), which was accompanied by decreased NO production.	arsenite	0-8	nitric oxide synthase 3	Bos taurus	50-54
25489418-5	2014	Treatment with arsenite also induced reactive oxygen species (ROS) production, and pretreatment with a ROS scavenger N-acetyl-L-cysteine (NAC) completely reversed the observed effect of arsenite on eNOS-Thr(497) phosphorylation.	arsenite	15-23	nitric oxide synthase 3	Bos taurus	198-202
25489418-5	2014	Treatment with arsenite also induced reactive oxygen species (ROS) production, and pretreatment with a ROS scavenger N-acetyl-L-cysteine (NAC) completely reversed the observed effect of arsenite on eNOS-Thr(497) phosphorylation.	arsenite	186-194	nitric oxide synthase 3	Bos taurus	198-202
25489418-7	2014	In contrast, treatment with PP1 inhibitor, calyculin A, mimicked the observed effect of arsenite on eNOS-Thr(497) phosphorylation.	arsenite	88-96	nitric oxide synthase 3	Bos taurus	100-104
25145660-6	2014	Smad2/3 mediated TGFbeta2 signaling, the key regulator of cardiac EMT, is disrupted by arsenite exposure.	arsenite	87-95	SMAD family member 2	Homo sapiens	0-7
25145660-6	2014	Smad2/3 mediated TGFbeta2 signaling, the key regulator of cardiac EMT, is disrupted by arsenite exposure.	arsenite	87-95	transforming growth factor beta 2	Homo sapiens	17-25
25145660-12	2014	Both arsenite and MMA (III) significantly inhibited Erk1/2 and Erk5 phosphorylation.	arsenite	5-13	mitogen-activated protein kinase 3	Homo sapiens	52-58
25145660-12	2014	Both arsenite and MMA (III) significantly inhibited Erk1/2 and Erk5 phosphorylation.	arsenite	5-13	mitogen-activated protein kinase 7	Homo sapiens	63-67
25010681-3	2014	We hypothesize that low concentration of AS could enhance metastasis and proliferation of transformed cancer cells by promoting EMT.	arsenite	41-43	IL2 inducible T cell kinase	Homo sapiens	128-131
24499675-0	2014	Arsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells.	arsenite	0-8	H3 histone pseudogene 16	Homo sapiens	46-49
24499675-1	2014	In this study, we investigate whether arsenite-induced DNA damage leads to p53-dependent premature senescence using human glioblastoma cells with p53-wild type (U87MG-neo) and p53 deficient (U87MG-E6).	arsenite	38-46	tumor protein p53	Homo sapiens	75-78
24499675-5	2014	This suggests that arsenite induces premature senescence as a result of DNA damage with heterochromatin forming through a p53/p21 dependent pathway.	arsenite	19-27	tumor protein p53	Homo sapiens	122-125
24499675-5	2014	This suggests that arsenite induces premature senescence as a result of DNA damage with heterochromatin forming through a p53/p21 dependent pathway.	arsenite	19-27	H3 histone pseudogene 16	Homo sapiens	126-129
24499675-7	2014	Taken together, arsenite reduces cell growth independently of p53 and induces premature senescence via p53/p21-dependent pathway following DNA damage.	arsenite	16-24	tumor protein p53	Homo sapiens	62-65
24499675-7	2014	Taken together, arsenite reduces cell growth independently of p53 and induces premature senescence via p53/p21-dependent pathway following DNA damage.	arsenite	16-24	tumor protein p53	Homo sapiens	103-106
24499675-7	2014	Taken together, arsenite reduces cell growth independently of p53 and induces premature senescence via p53/p21-dependent pathway following DNA damage.	arsenite	16-24	H3 histone pseudogene 16	Homo sapiens	107-110
25554729-2	2014	Endogenous PACT/RAX activates PKR in response to diverse stress signals such as serum starvation, and peroxide or arsenite treatment.	arsenite	114-122	protein kinase, interferon inducible double stranded RNA dependent activator	Mus musculus	11-15
25554729-2	2014	Endogenous PACT/RAX activates PKR in response to diverse stress signals such as serum starvation, and peroxide or arsenite treatment.	arsenite	114-122	retina and anterior neural fold homeobox	Mus musculus	16-19
25554729-2	2014	Endogenous PACT/RAX activates PKR in response to diverse stress signals such as serum starvation, and peroxide or arsenite treatment.	arsenite	114-122	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	30-33
24995390-9	2014	The strong stimulation of GSH export by arsenite was prevented by MK571, an inhibitor of the multidrug resistance protein 1, suggesting that this transporter mediates the accelerated GSH export.	arsenite	40-48	ATP binding cassette subfamily C member 1	Rattus norvegicus	93-123
25237887-0	2014	Arsenite-activated JNK signaling enhances CPEB4-Vinexin interaction to facilitate stress granule assembly and cell survival.	arsenite	0-8	mitogen-activated protein kinase 8	Homo sapiens	19-22
25271956-7	2014	In an arsenite-susceptible individual, arsenite suppressed the activation of Th1 (Tbet) cells, and decreased the percentage of cells in the double positive Th17 (RORgammat) and Treg (FoxP3) population.	arsenite	6-14	negative elongation factor complex member C/D	Homo sapiens	77-80
25271956-7	2014	In an arsenite-susceptible individual, arsenite suppressed the activation of Th1 (Tbet) cells, and decreased the percentage of cells in the double positive Th17 (RORgammat) and Treg (FoxP3) population.	arsenite	6-14	forkhead box P3	Homo sapiens	183-188
25271956-7	2014	In an arsenite-susceptible individual, arsenite suppressed the activation of Th1 (Tbet) cells, and decreased the percentage of cells in the double positive Th17 (RORgammat) and Treg (FoxP3) population.	arsenite	39-47	negative elongation factor complex member C/D	Homo sapiens	77-80
25271956-7	2014	In an arsenite-susceptible individual, arsenite suppressed the activation of Th1 (Tbet) cells, and decreased the percentage of cells in the double positive Th17 (RORgammat) and Treg (FoxP3) population.	arsenite	39-47	forkhead box P3	Homo sapiens	183-188
25237887-0	2014	Arsenite-activated JNK signaling enhances CPEB4-Vinexin interaction to facilitate stress granule assembly and cell survival.	arsenite	0-8	cytoplasmic polyadenylation element binding protein 4	Homo sapiens	42-47
25170678-0	2014	Arsenite binds to the RING finger domains of RNF20-RNF40 histone E3 ubiquitin ligase and inhibits DNA double-strand break repair.	arsenite	0-8	ring finger protein 20	Homo sapiens	45-50
25237887-0	2014	Arsenite-activated JNK signaling enhances CPEB4-Vinexin interaction to facilitate stress granule assembly and cell survival.	arsenite	0-8	sorbin and SH3 domain containing 3	Homo sapiens	48-55
25170678-0	2014	Arsenite binds to the RING finger domains of RNF20-RNF40 histone E3 ubiquitin ligase and inhibits DNA double-strand break repair.	arsenite	0-8	ring finger protein 40	Homo sapiens	51-56
25170678-5	2014	Herein, we found that arsenite could bind directly to the RING finger domains of RNF20 and RNF40 in vitro and in cells, and treatment with arsenite resulted in substantially impaired H2B ubiquitination in multiple cell lines.	arsenite	22-30	ring finger protein 20	Homo sapiens	81-86
25170678-5	2014	Herein, we found that arsenite could bind directly to the RING finger domains of RNF20 and RNF40 in vitro and in cells, and treatment with arsenite resulted in substantially impaired H2B ubiquitination in multiple cell lines.	arsenite	22-30	ring finger protein 40	Homo sapiens	91-96
25170678-5	2014	Herein, we found that arsenite could bind directly to the RING finger domains of RNF20 and RNF40 in vitro and in cells, and treatment with arsenite resulted in substantially impaired H2B ubiquitination in multiple cell lines.	arsenite	139-147	ring finger protein 20	Homo sapiens	81-86
25170678-5	2014	Herein, we found that arsenite could bind directly to the RING finger domains of RNF20 and RNF40 in vitro and in cells, and treatment with arsenite resulted in substantially impaired H2B ubiquitination in multiple cell lines.	arsenite	139-147	ring finger protein 40	Homo sapiens	91-96
25237887-3	2014	In keeping with the results obtained from the study of other RNA-binding proteins, we found CPEB4 localized in SGs in various arsenite-treated cells.	arsenite	126-134	cytoplasmic polyadenylation element binding protein 4	Homo sapiens	92-97
25237887-6	2014	Unexpectedly, Vinexin is translocated from FAs to SGs under arsenite-induced stress.	arsenite	60-68	sorbin and SH3 domain containing 3	Homo sapiens	14-21
25170678-6	2014	Exposure to arsenite also diminished the recruitment of BRCA1 and RAD51 to laser-induced DNA double-strand break (DSB) sites, compromised DNA DSB repair in human cells, and rendered cells sensitive toward a radiomimetic agent, neocarzinostatin.	arsenite	12-20	BRCA1 DNA repair associated	Homo sapiens	56-61
24942733-0	2014	Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution.	arsenite	0-8	leucine rich repeat kinase 2	Homo sapiens	69-97
25170678-6	2014	Exposure to arsenite also diminished the recruitment of BRCA1 and RAD51 to laser-induced DNA double-strand break (DSB) sites, compromised DNA DSB repair in human cells, and rendered cells sensitive toward a radiomimetic agent, neocarzinostatin.	arsenite	12-20	RAD51 recombinase	Homo sapiens	66-71
25258480-0	2014	Comparative Molecular Docking Studies with ABCC1 and Aquaporin 9 in the Arsenite Complex Efflux.	arsenite	72-80	ATP binding cassette subfamily C member 1	Homo sapiens	43-48
25258480-0	2014	Comparative Molecular Docking Studies with ABCC1 and Aquaporin 9 in the Arsenite Complex Efflux.	arsenite	72-80	aquaporin 9	Homo sapiens	53-64
24957728-9	2014	Further, a solution-phase, non-resonant SERS spectroscopic detection method for an inorganic contaminant of ground water, arsenite, has also been developed.	arsenite	122-130	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	40-44
25204677-4	2014	For instance, the Caenorhabditis elegans Nrf2 orthologue, SKN-1, is activated in response to arsenite by the stress-activated p38-related kinase, PMK-1, leading to increased expression of phase 2 enzymes.	arsenite	93-101	NFE2 like bZIP transcription factor 2	Homo sapiens	41-45
25204677-4	2014	For instance, the Caenorhabditis elegans Nrf2 orthologue, SKN-1, is activated in response to arsenite by the stress-activated p38-related kinase, PMK-1, leading to increased expression of phase 2 enzymes.	arsenite	93-101	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	58-63
25204677-4	2014	For instance, the Caenorhabditis elegans Nrf2 orthologue, SKN-1, is activated in response to arsenite by the stress-activated p38-related kinase, PMK-1, leading to increased expression of phase 2 enzymes.	arsenite	93-101	Mitogen-activated protein kinase pmk-1	Caenorhabditis elegans	146-151
25204677-10	2014	Notably, we demonstrate that the candidate activator TIR-1(SARM1) and the MAPKKK NSY-1(Ask1) are required for the arsenite-induced activation of PMK-1.	arsenite	114-122	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase;NAD(+) hydrolase tir-1	Caenorhabditis elegans	53-58
25204677-10	2014	Notably, we demonstrate that the candidate activator TIR-1(SARM1) and the MAPKKK NSY-1(Ask1) are required for the arsenite-induced activation of PMK-1.	arsenite	114-122	Mitogen-activated protein kinase pmk-1	Caenorhabditis elegans	145-150
24942733-0	2014	Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution.	arsenite	0-8	leucine rich repeat kinase 2	Homo sapiens	99-104
24942733-6	2014	Arsenite-induced dephosphorylation is accompanied by loss of 14-3-3 binding and is observed in wild type, G2019S, and kinase-dead D2017A LRRK2.	arsenite	0-8	leucine rich repeat kinase 2	Homo sapiens	137-142
24942733-7	2014	Arsenite stress stimulates LRRK2 self-association and association with protein phosphatase 1alpha, decreases kinase activity and GTP binding in vitro, and induces translocation of LRRK2 to centrosomes.	arsenite	0-8	leucine rich repeat kinase 2	Homo sapiens	27-32
24942733-7	2014	Arsenite stress stimulates LRRK2 self-association and association with protein phosphatase 1alpha, decreases kinase activity and GTP binding in vitro, and induces translocation of LRRK2 to centrosomes.	arsenite	0-8	leucine rich repeat kinase 2	Homo sapiens	180-185
24942733-8	2014	Our data indicate that signaling events induced by arsenite and oxidative stress may regulate LRRK2 function.	arsenite	51-59	leucine rich repeat kinase 2	Homo sapiens	94-99
24898249-0	2014	Stress-induced start codon fidelity regulates arsenite-inducible regulatory particle-associated protein (AIRAP) translation.	arsenite	46-54	zinc finger AN1-type containing 2A	Homo sapiens	105-110
24865968-5	2014	HuR knockdown or Chk2/p38(MAPK) double knockdown inhibited the arsenite-stimulated production of TRA2beta4 and increased Tra2beta protein, facilitating Tra2beta-dependent inclusion of exons in target pre-mRNAs.	arsenite	63-71	ELAV like RNA binding protein 1	Homo sapiens	0-3
24865968-5	2014	HuR knockdown or Chk2/p38(MAPK) double knockdown inhibited the arsenite-stimulated production of TRA2beta4 and increased Tra2beta protein, facilitating Tra2beta-dependent inclusion of exons in target pre-mRNAs.	arsenite	63-71	checkpoint kinase 2	Homo sapiens	17-21
24865968-5	2014	HuR knockdown or Chk2/p38(MAPK) double knockdown inhibited the arsenite-stimulated production of TRA2beta4 and increased Tra2beta protein, facilitating Tra2beta-dependent inclusion of exons in target pre-mRNAs.	arsenite	63-71	mitogen-activated protein kinase 14	Homo sapiens	22-25
24865968-5	2014	HuR knockdown or Chk2/p38(MAPK) double knockdown inhibited the arsenite-stimulated production of TRA2beta4 and increased Tra2beta protein, facilitating Tra2beta-dependent inclusion of exons in target pre-mRNAs.	arsenite	63-71	transformer 2 beta homolog	Homo sapiens	121-129
24865968-5	2014	HuR knockdown or Chk2/p38(MAPK) double knockdown inhibited the arsenite-stimulated production of TRA2beta4 and increased Tra2beta protein, facilitating Tra2beta-dependent inclusion of exons in target pre-mRNAs.	arsenite	63-71	transformer 2 beta homolog	Homo sapiens	152-160
24898249-6	2014	We have identified arsenite- inducible regulatory particle-associated protein (AIRAP) transcript to be translationally induced during arsenite stress conditions.	arsenite	19-27	zinc finger AN1-type containing 2A	Homo sapiens	79-84
24768856-8	2014	At later time points, matrix metalloproteinase 9 (mmp9) expression was upregulated, suggesting that arsenite affects the composition of the extracellular matrix.	arsenite	100-108	matrix metallopeptidase 9	Danio rerio	22-48
24768856-8	2014	At later time points, matrix metalloproteinase 9 (mmp9) expression was upregulated, suggesting that arsenite affects the composition of the extracellular matrix.	arsenite	100-108	matrix metallopeptidase 9	Danio rerio	50-54
24689980-7	2014	Furthermore, we show that stress-independent HSF1 activation decreases intracellular aggregation of a model polyglutamine-containing protein and reduces the cellular toxicity of environmental toxins like arsenite that disrupt cytosolic proteostasis.	arsenite	204-212	heat shock transcription factor 1	Homo sapiens	45-49
22859221-10	2014	These results suggested that beta-catenin plays a role in arsenite-induced VEGF in SH-SY5Y cells, and the induction of beta-catenin by arsenite is mediated by inhibition of GSK3 without activating its upstream kinase Akt.	arsenite	58-66	catenin beta 1	Homo sapiens	29-41
24704393-0	2014	The acquisition of cancer stem cell-like properties and neoplastic transformation of human keratinocytes induced by arsenite involves epigenetic silencing of let-7c via Ras/NF-kappaB.	arsenite	116-124	microRNA let-7c	Homo sapiens	158-164
24704393-0	2014	The acquisition of cancer stem cell-like properties and neoplastic transformation of human keratinocytes induced by arsenite involves epigenetic silencing of let-7c via Ras/NF-kappaB.	arsenite	116-124	nuclear factor kappa B subunit 1	Homo sapiens	173-182
24704393-4	2014	Here, we report that there are decreased levels of let-7a, let-7b, and let-7c in human keratinocyte HaCaT cells during malignant transformation induced by a low concentration (1.0muM) of arsenite.	arsenite	187-195	microRNA let-7b	Homo sapiens	59-65
24704393-4	2014	Here, we report that there are decreased levels of let-7a, let-7b, and let-7c in human keratinocyte HaCaT cells during malignant transformation induced by a low concentration (1.0muM) of arsenite.	arsenite	187-195	microRNA let-7c	Homo sapiens	71-77
24704393-5	2014	The process by which arsenite reduces the level of let-7c apparently involves methylation, for 5-aza-2"-deoxycytidine, an inhibitor of methyltransferases, prevents arsenite-induced hypermethylation, decreases the level of let-7c, and thereby blocks arsenite-induced activation of the Ras/NF-kappaB signal pathway.	arsenite	21-29	microRNA let-7c	Homo sapiens	51-57
24704393-5	2014	The process by which arsenite reduces the level of let-7c apparently involves methylation, for 5-aza-2"-deoxycytidine, an inhibitor of methyltransferases, prevents arsenite-induced hypermethylation, decreases the level of let-7c, and thereby blocks arsenite-induced activation of the Ras/NF-kappaB signal pathway.	arsenite	21-29	microRNA let-7c	Homo sapiens	222-228
24704393-5	2014	The process by which arsenite reduces the level of let-7c apparently involves methylation, for 5-aza-2"-deoxycytidine, an inhibitor of methyltransferases, prevents arsenite-induced hypermethylation, decreases the level of let-7c, and thereby blocks arsenite-induced activation of the Ras/NF-kappaB signal pathway.	arsenite	21-29	nuclear factor kappa B subunit 1	Homo sapiens	288-297
24704393-5	2014	The process by which arsenite reduces the level of let-7c apparently involves methylation, for 5-aza-2"-deoxycytidine, an inhibitor of methyltransferases, prevents arsenite-induced hypermethylation, decreases the level of let-7c, and thereby blocks arsenite-induced activation of the Ras/NF-kappaB signal pathway.	arsenite	164-172	microRNA let-7c	Homo sapiens	51-57
24704393-5	2014	The process by which arsenite reduces the level of let-7c apparently involves methylation, for 5-aza-2"-deoxycytidine, an inhibitor of methyltransferases, prevents arsenite-induced hypermethylation, decreases the level of let-7c, and thereby blocks arsenite-induced activation of the Ras/NF-kappaB signal pathway.	arsenite	164-172	microRNA let-7c	Homo sapiens	222-228
24704393-5	2014	The process by which arsenite reduces the level of let-7c apparently involves methylation, for 5-aza-2"-deoxycytidine, an inhibitor of methyltransferases, prevents arsenite-induced hypermethylation, decreases the level of let-7c, and thereby blocks arsenite-induced activation of the Ras/NF-kappaB signal pathway.	arsenite	164-172	nuclear factor kappa B subunit 1	Homo sapiens	288-297
24704393-5	2014	The process by which arsenite reduces the level of let-7c apparently involves methylation, for 5-aza-2"-deoxycytidine, an inhibitor of methyltransferases, prevents arsenite-induced hypermethylation, decreases the level of let-7c, and thereby blocks arsenite-induced activation of the Ras/NF-kappaB signal pathway.	arsenite	164-172	microRNA let-7c	Homo sapiens	51-57
24704393-5	2014	The process by which arsenite reduces the level of let-7c apparently involves methylation, for 5-aza-2"-deoxycytidine, an inhibitor of methyltransferases, prevents arsenite-induced hypermethylation, decreases the level of let-7c, and thereby blocks arsenite-induced activation of the Ras/NF-kappaB signal pathway.	arsenite	164-172	microRNA let-7c	Homo sapiens	222-228
24704393-5	2014	The process by which arsenite reduces the level of let-7c apparently involves methylation, for 5-aza-2"-deoxycytidine, an inhibitor of methyltransferases, prevents arsenite-induced hypermethylation, decreases the level of let-7c, and thereby blocks arsenite-induced activation of the Ras/NF-kappaB signal pathway.	arsenite	164-172	nuclear factor kappa B subunit 1	Homo sapiens	288-297
24704393-8	2014	Thus, we conclude that epigenetic silencing of let-7c via Ras/NF-kappaB is involved in the acquisition of cancer stem cell-like properties and neoplastic transformation of HaCaT cells induced by arsenite, which contribute to the tumorigenesis of arsenite.	arsenite	195-203	microRNA let-7c	Homo sapiens	47-53
24704393-8	2014	Thus, we conclude that epigenetic silencing of let-7c via Ras/NF-kappaB is involved in the acquisition of cancer stem cell-like properties and neoplastic transformation of HaCaT cells induced by arsenite, which contribute to the tumorigenesis of arsenite.	arsenite	195-203	nuclear factor kappa B subunit 1	Homo sapiens	62-71
24704393-8	2014	Thus, we conclude that epigenetic silencing of let-7c via Ras/NF-kappaB is involved in the acquisition of cancer stem cell-like properties and neoplastic transformation of HaCaT cells induced by arsenite, which contribute to the tumorigenesis of arsenite.	arsenite	246-254	microRNA let-7c	Homo sapiens	47-53
24704393-8	2014	Thus, we conclude that epigenetic silencing of let-7c via Ras/NF-kappaB is involved in the acquisition of cancer stem cell-like properties and neoplastic transformation of HaCaT cells induced by arsenite, which contribute to the tumorigenesis of arsenite.	arsenite	246-254	nuclear factor kappa B subunit 1	Homo sapiens	62-71
22859221-0	2014	beta-catenin involvement in arsenite-induced VEGF expression in neuroblastoma SH-SY5Y cells.	arsenite	28-36	catenin beta 1	Homo sapiens	0-12
22859221-0	2014	beta-catenin involvement in arsenite-induced VEGF expression in neuroblastoma SH-SY5Y cells.	arsenite	28-36	vascular endothelial growth factor A	Homo sapiens	45-49
22859221-4	2014	In the present study, we demonstrated that arsenite induced VEGF expression in neuroblastoma SH-SY5Y cells without induction of HIF-1alpha, a well-known transcriptional activator for VEGF suggesting that arsenite-induced VEGF expression in SH-SY5Y cells may not require HIF-1alpha activation.	arsenite	43-51	vascular endothelial growth factor A	Homo sapiens	60-64
22859221-4	2014	In the present study, we demonstrated that arsenite induced VEGF expression in neuroblastoma SH-SY5Y cells without induction of HIF-1alpha, a well-known transcriptional activator for VEGF suggesting that arsenite-induced VEGF expression in SH-SY5Y cells may not require HIF-1alpha activation.	arsenite	43-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	270-280
22859221-4	2014	In the present study, we demonstrated that arsenite induced VEGF expression in neuroblastoma SH-SY5Y cells without induction of HIF-1alpha, a well-known transcriptional activator for VEGF suggesting that arsenite-induced VEGF expression in SH-SY5Y cells may not require HIF-1alpha activation.	arsenite	204-212	hypoxia inducible factor 1 subunit alpha	Homo sapiens	270-280
22859221-6	2014	We therefore investigated whether beta-catenin was involved in arsenite-induced VEGF expression in SH-SY5Y cells.	arsenite	63-71	catenin beta 1	Homo sapiens	34-46
22859221-6	2014	We therefore investigated whether beta-catenin was involved in arsenite-induced VEGF expression in SH-SY5Y cells.	arsenite	63-71	vascular endothelial growth factor A	Homo sapiens	80-84
22859221-7	2014	Treatment of arsenite caused beta-catenin accumulation in the nucleus.	arsenite	13-21	catenin beta 1	Homo sapiens	29-41
22859221-8	2014	Additionally, arsenite treatment decreased the activity of GSK3, an enzyme that phosphorylates and targets beta-catenin for degradation by proteasome, without activation of its upstream kinase, Akt.	arsenite	14-22	catenin beta 1	Homo sapiens	107-119
22859221-10	2014	These results suggested that beta-catenin plays a role in arsenite-induced VEGF in SH-SY5Y cells, and the induction of beta-catenin by arsenite is mediated by inhibition of GSK3 without activating its upstream kinase Akt.	arsenite	58-66	vascular endothelial growth factor A	Homo sapiens	75-79
22859221-9	2014	Inhibition of PI3K/Akt which negatively regulates GSK3 activity by LY294002 resulted in a decrease in arsenite-mediated beta-catenin nuclear accumulation, and VEGF expression.	arsenite	102-110	AKT serine/threonine kinase 1	Homo sapiens	19-22
22859221-9	2014	Inhibition of PI3K/Akt which negatively regulates GSK3 activity by LY294002 resulted in a decrease in arsenite-mediated beta-catenin nuclear accumulation, and VEGF expression.	arsenite	102-110	catenin beta 1	Homo sapiens	120-132
22859221-10	2014	These results suggested that beta-catenin plays a role in arsenite-induced VEGF in SH-SY5Y cells, and the induction of beta-catenin by arsenite is mediated by inhibition of GSK3 without activating its upstream kinase Akt.	arsenite	135-143	catenin beta 1	Homo sapiens	119-131
22859221-10	2014	These results suggested that beta-catenin plays a role in arsenite-induced VEGF in SH-SY5Y cells, and the induction of beta-catenin by arsenite is mediated by inhibition of GSK3 without activating its upstream kinase Akt.	arsenite	135-143	AKT serine/threonine kinase 1	Homo sapiens	217-220
24190502-5	2014	Our findings indicate that MEF Ogg1-/- cells are more sensitive to arsenite-induced acute toxicity, genotoxicity and ODD.	arsenite	67-75	E74 like ETS transcription factor 4	Homo sapiens	27-30
24611629-4	2014	Herein we analyzed the interaction of arsenite, MMA(III), and ATO with C2H2, C3H1, and C4 configurations of zinc fingers using UV-vis, cobalt, fluorescence, and mass spectrometry.	arsenite	38-46	complement C4A (Rodgers blood group)	Homo sapiens	77-89
24535192-0	2014	Acute and long-term effects of arsenite in HepG2 cells: modulation of insulin signaling.	arsenite	31-39	insulin	Homo sapiens	70-77
24535192-4	2014	The present study aimed at investigating the effect of short and long-term exposure to arsenite on insulin signaling in HepG2 human hepatoma cells, the role of PI3K/Akt signaling therein and the modulation of target genes controlled by insulin.	arsenite	87-95	insulin	Homo sapiens	99-106
24535192-5	2014	Exposure of cells to arsenite for 24 h rendered cells less responsive toward stimulation of Akt by insulin.	arsenite	21-29	AKT serine/threonine kinase 1	Homo sapiens	92-95
24535192-5	2014	Exposure of cells to arsenite for 24 h rendered cells less responsive toward stimulation of Akt by insulin.	arsenite	21-29	insulin	Homo sapiens	99-106
24535192-6	2014	At the same time, short-term exposure to arsenite induced a concentration-dependent increase in phosphorylation of Akt at Ser-473, followed by phosphorylation of FoxO proteins at sites known to be phosphorylated by Akt.	arsenite	41-49	AKT serine/threonine kinase 1	Homo sapiens	115-118
24535192-6	2014	At the same time, short-term exposure to arsenite induced a concentration-dependent increase in phosphorylation of Akt at Ser-473, followed by phosphorylation of FoxO proteins at sites known to be phosphorylated by Akt.	arsenite	41-49	AKT serine/threonine kinase 1	Homo sapiens	215-218
24535192-8	2014	Arsenite exposure resulted in attenuation of FoxO DNA binding and in nuclear exclusion of FoxO1a-EGFP.	arsenite	0-8	forkhead box O1	Homo sapiens	90-96
24535192-9	2014	A 24-h exposure of HepG2 cells to submicromolar concentrations of arsenite resulted in downregulation of glucose 6-phosphatase (G6Pase) and selenoprotein P (SelP) mRNA levels.	arsenite	66-74	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	105-126
24535192-9	2014	A 24-h exposure of HepG2 cells to submicromolar concentrations of arsenite resulted in downregulation of glucose 6-phosphatase (G6Pase) and selenoprotein P (SelP) mRNA levels.	arsenite	66-74	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	128-134
24535192-9	2014	A 24-h exposure of HepG2 cells to submicromolar concentrations of arsenite resulted in downregulation of glucose 6-phosphatase (G6Pase) and selenoprotein P (SelP) mRNA levels.	arsenite	66-74	selenoprotein P	Homo sapiens	140-155
24535192-9	2014	A 24-h exposure of HepG2 cells to submicromolar concentrations of arsenite resulted in downregulation of glucose 6-phosphatase (G6Pase) and selenoprotein P (SelP) mRNA levels.	arsenite	66-74	selenoprotein P	Homo sapiens	157-161
24535192-10	2014	Curiously, arsenite had a dual effect on SelP protein levels, inducing a small increase in the nanomolar and a distinct decrease in the micromolar concentration range.	arsenite	11-19	selenoprotein P	Homo sapiens	41-45
24535192-11	2014	Interestingly, arsenite-induced long-term effects on G6Pase and SelP mRNA or SelP protein levels were not blocked by the PI3K inhibitor, wortmannin.	arsenite	15-23	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	53-59
24535192-11	2014	Interestingly, arsenite-induced long-term effects on G6Pase and SelP mRNA or SelP protein levels were not blocked by the PI3K inhibitor, wortmannin.	arsenite	15-23	selenoprotein P	Homo sapiens	64-68
24535192-11	2014	Interestingly, arsenite-induced long-term effects on G6Pase and SelP mRNA or SelP protein levels were not blocked by the PI3K inhibitor, wortmannin.	arsenite	15-23	selenoprotein P	Homo sapiens	77-81
24535192-12	2014	In conclusion, arsenite perturbs cellular signaling pathways involved in fuel metabolism: it impairs cellular responsiveness toward insulin, while at the same time stimulating insulin-like signaling to attenuate the expression of genes involved in glucose metabolism and the release of the hepatokine SelP, which is known to modulate peripheral insulin sensitivity.	arsenite	15-23	insulin	Homo sapiens	132-139
24535192-12	2014	In conclusion, arsenite perturbs cellular signaling pathways involved in fuel metabolism: it impairs cellular responsiveness toward insulin, while at the same time stimulating insulin-like signaling to attenuate the expression of genes involved in glucose metabolism and the release of the hepatokine SelP, which is known to modulate peripheral insulin sensitivity.	arsenite	15-23	insulin	Homo sapiens	176-183
24617811-1	2014	This study demonstrates that the production of reactive oxidizing species (e.g., hydroxyl radical ( OH)) during the photolysis of nitrite (NO2(-)) or nitrate (NO3(-)) leads to the oxidative conversion of arsenite (As(III)) to arsenate (As(V)).	arsenite	204-212	NBL1, DAN family BMP antagonist	Homo sapiens	159-162
24357338-4	2014	Annexin V-fluorescein isothiocyanate assay showed that apoptosis was obviously induced by arsenite treatment.	arsenite	90-98	annexin A5	Rattus norvegicus	0-9
24357338-5	2014	High phosphorylation expressions of p38 and extracellular signal-regulated kinases (ERK1/2), but not of c-Jun N-terminal kinases were observed due to arsenite treatment by western blotting analysis.	arsenite	150-158	mitogen activated protein kinase 14	Rattus norvegicus	36-39
24357338-5	2014	High phosphorylation expressions of p38 and extracellular signal-regulated kinases (ERK1/2), but not of c-Jun N-terminal kinases were observed due to arsenite treatment by western blotting analysis.	arsenite	150-158	mitogen activated protein kinase 3	Rattus norvegicus	84-90
24357338-6	2014	Furthermore, SB203580 (an inhibitor of p38) decreased the percentage of apoptotic cells whereas arsenite-stimulated toxicity was enhanced by U0126 (an inhibitor of ERK1/2).	arsenite	96-104	mitogen activated protein kinase 3	Rattus norvegicus	164-170
24357338-7	2014	Taken together, these data suggest that p38 contributes to arsenite-induced apoptosis of rat CGNs, but ERK1/2 may involve in cell growth and survival.	arsenite	59-67	mitogen activated protein kinase 14	Rattus norvegicus	40-43
24231679-0	2014	Roles of YB-1 under arsenite-induced stress: translational activation of HSP70 mRNA and control of the number of stress granules.	arsenite	20-28	Y box protein 1	Mus musculus	9-13
24751519-0	2014	IKK-beta/NF-kappaB p65 mediates p27(Kip1) protein degradation in arsenite response.	arsenite	65-73	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	0-8
24751519-0	2014	IKK-beta/NF-kappaB p65 mediates p27(Kip1) protein degradation in arsenite response.	arsenite	65-73	nuclear factor kappa B subunit 1	Homo sapiens	9-18
24751519-0	2014	IKK-beta/NF-kappaB p65 mediates p27(Kip1) protein degradation in arsenite response.	arsenite	65-73	RELA proto-oncogene, NF-kB subunit	Homo sapiens	19-22
24751519-0	2014	IKK-beta/NF-kappaB p65 mediates p27(Kip1) protein degradation in arsenite response.	arsenite	65-73	zinc ribbon domain containing 2	Homo sapiens	32-35
24751519-0	2014	IKK-beta/NF-kappaB p65 mediates p27(Kip1) protein degradation in arsenite response.	arsenite	65-73	cyclin dependent kinase inhibitor 1B	Homo sapiens	36-40
24751519-3	2014	We here explored the inhibitory regulation of IKKbeta on p27(Kip1) expression following arsenite exposure.	arsenite	88-96	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	46-53
24751519-3	2014	We here explored the inhibitory regulation of IKKbeta on p27(Kip1) expression following arsenite exposure.	arsenite	88-96	zinc ribbon domain containing 2	Homo sapiens	57-60
24751519-3	2014	We here explored the inhibitory regulation of IKKbeta on p27(Kip1) expression following arsenite exposure.	arsenite	88-96	cyclin dependent kinase inhibitor 1B	Homo sapiens	61-65
24751519-4	2014	We found that although the basal level of p27(Kip1) expression in the IKKbeta(-/-) cells is much lower than that in the IKKbeta(+/+) cells, the deletion of IKKbeta in the MEFs led to a marked increase in p27(Kip1) protein induction due to arsenite exposure in comparison to that in the IKKbeta(+/+) cells.	arsenite	239-247	zinc ribbon domain containing 2	Homo sapiens	42-45
24751519-7	2014	Moreover, the results obtained from the comparison of arsenite-induced GSK3beta activation among transfectants of WT, IKKbeta(-/-) and IKKbeta(-/-) (IKKbeta), and the utilization of GSKbeta shRNA, demonstrated that IKKbeta regulation of p27 protein degradation was mediated by GSK3beta following arsenite exposure.	arsenite	54-62	glycogen synthase kinase 3 beta	Homo sapiens	71-79
24751519-7	2014	Moreover, the results obtained from the comparison of arsenite-induced GSK3beta activation among transfectants of WT, IKKbeta(-/-) and IKKbeta(-/-) (IKKbeta), and the utilization of GSKbeta shRNA, demonstrated that IKKbeta regulation of p27 protein degradation was mediated by GSK3beta following arsenite exposure.	arsenite	54-62	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	118-125
24751519-7	2014	Moreover, the results obtained from the comparison of arsenite-induced GSK3beta activation among transfectants of WT, IKKbeta(-/-) and IKKbeta(-/-) (IKKbeta), and the utilization of GSKbeta shRNA, demonstrated that IKKbeta regulation of p27 protein degradation was mediated by GSK3beta following arsenite exposure.	arsenite	54-62	zinc ribbon domain containing 2	Homo sapiens	237-240
24751519-7	2014	Moreover, the results obtained from the comparison of arsenite-induced GSK3beta activation among transfectants of WT, IKKbeta(-/-) and IKKbeta(-/-) (IKKbeta), and the utilization of GSKbeta shRNA, demonstrated that IKKbeta regulation of p27 protein degradation was mediated by GSK3beta following arsenite exposure.	arsenite	54-62	glycogen synthase kinase 3 beta	Homo sapiens	277-285
24535192-12	2014	In conclusion, arsenite perturbs cellular signaling pathways involved in fuel metabolism: it impairs cellular responsiveness toward insulin, while at the same time stimulating insulin-like signaling to attenuate the expression of genes involved in glucose metabolism and the release of the hepatokine SelP, which is known to modulate peripheral insulin sensitivity.	arsenite	15-23	selenoprotein P	Homo sapiens	301-305
24535192-12	2014	In conclusion, arsenite perturbs cellular signaling pathways involved in fuel metabolism: it impairs cellular responsiveness toward insulin, while at the same time stimulating insulin-like signaling to attenuate the expression of genes involved in glucose metabolism and the release of the hepatokine SelP, which is known to modulate peripheral insulin sensitivity.	arsenite	15-23	insulin	Homo sapiens	176-183
24231679-0	2014	Roles of YB-1 under arsenite-induced stress: translational activation of HSP70 mRNA and control of the number of stress granules.	arsenite	20-28	heat shock protein 1B	Mus musculus	73-78
24231679-6	2014	RESULTS: Arsenite treatment reduced the translation level of GluR2 mRNA; concomitantly, YB-1-bound HSP70 mRNA was increased and its translation was induced.	arsenite	9-17	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	61-66
24231679-6	2014	RESULTS: Arsenite treatment reduced the translation level of GluR2 mRNA; concomitantly, YB-1-bound HSP70 mRNA was increased and its translation was induced.	arsenite	9-17	heat shock protein 1B	Mus musculus	99-104
24231679-9	2014	YB-1 depletion abrogated the arsenite-responsive activation of HSP70 synthesis, but SGs harboring both mRNAs were still assembled.	arsenite	29-37	Y box protein 1	Mus musculus	0-4
24231679-9	2014	YB-1 depletion abrogated the arsenite-responsive activation of HSP70 synthesis, but SGs harboring both mRNAs were still assembled.	arsenite	29-37	heat shock protein 1B	Mus musculus	63-68
24231679-11	2014	CONCLUSION: In arsenite-treated cells, YB-1 mediates the translational activation of HSP70 mRNA and also controls the number of SGs through inhibition of their assembly.	arsenite	15-23	Y box protein 1	Mus musculus	39-43
24231679-11	2014	CONCLUSION: In arsenite-treated cells, YB-1 mediates the translational activation of HSP70 mRNA and also controls the number of SGs through inhibition of their assembly.	arsenite	15-23	heat shock protein 1B	Mus musculus	85-90
24190502-5	2014	Our findings indicate that MEF Ogg1-/- cells are more sensitive to arsenite-induced acute toxicity, genotoxicity and ODD.	arsenite	67-75	8-oxoguanine DNA glycosylase	Homo sapiens	31-35
24190502-6	2014	Long-term exposure to sub-toxic doses of arsenite generates a detectable increase in ODD and genotoxic DNA damage only in MEF Ogg1-deficient cells.	arsenite	41-49	odd-skipped related transcription factor 1	Homo sapiens	85-88
24190502-6	2014	Long-term exposure to sub-toxic doses of arsenite generates a detectable increase in ODD and genotoxic DNA damage only in MEF Ogg1-deficient cells.	arsenite	41-49	E74 like ETS transcription factor 4	Homo sapiens	122-125
24190502-6	2014	Long-term exposure to sub-toxic doses of arsenite generates a detectable increase in ODD and genotoxic DNA damage only in MEF Ogg1-deficient cells.	arsenite	41-49	8-oxoguanine DNA glycosylase	Homo sapiens	126-130
24284797-5	2014	A chemiluminescence-based NMD reporter assay system demonstrated that arsenite treatment inhibited NMD activity and increased SRSF3-PTC mRNA levels in the cytoplasm, facilitating translation of a truncated SRSF3 protein (SRSF3-TR) from SRSF3-PTC mRNA.	arsenite	70-78	serine and arginine rich splicing factor 3	Homo sapiens	126-131
24554125-0	2014	In silico and in vivo studies of molecular structures and mechanisms of AtPCS1 protein involved in binding arsenite and/or cadmium in plant cells.	arsenite	107-115	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	72-78
24473123-5	2014	Exposure of HEK293 cells to inorganic arsenic (arsenite) showed reduced levels of MAML1, in combination with a decreased proliferation rate.	arsenite	47-55	mastermind like transcriptional coactivator 1	Homo sapiens	82-87
23957350-9	2014	The MDT-15 interacting nuclear hormone receptor, NHR-64, is specifically required for tBOOH but not arsenite resistance, but NHR-64 is dispensable for the transcriptional response to tBOOH.	arsenite	100-108	Mediator of RNA polymerase II transcription subunit 15	Caenorhabditis elegans	4-10
23961884-5	2014	The activity of lipoamide dehydrogenase in isolated mitochondria was sensitive to arsenite, but not arsenate, indicating that arsenite could be the mediator of the observed phenotypes.	arsenite	82-90	lipoamide dehydrogenase 1	Arabidopsis thaliana	16-39
23961884-5	2014	The activity of lipoamide dehydrogenase in isolated mitochondria was sensitive to arsenite, but not arsenate, indicating that arsenite could be the mediator of the observed phenotypes.	arsenite	126-134	lipoamide dehydrogenase 1	Arabidopsis thaliana	16-39
23396362-3	2014	We found that the deletion of p50 (p50-/-) impaired arsenite-induced p53 protein expression, which could be restored after reconstitutive expression of HA-p50 in p50-/- cells, p50-/-(Ad-HA-p50).	arsenite	52-60	nuclear factor kappa B subunit 1	Homo sapiens	30-33
23396362-3	2014	We found that the deletion of p50 (p50-/-) impaired arsenite-induced p53 protein expression, which could be restored after reconstitutive expression of HA-p50 in p50-/- cells, p50-/-(Ad-HA-p50).	arsenite	52-60	nuclear factor kappa B subunit 1	Homo sapiens	35-38
23396362-3	2014	We found that the deletion of p50 (p50-/-) impaired arsenite-induced p53 protein expression, which could be restored after reconstitutive expression of HA-p50 in p50-/- cells, p50-/-(Ad-HA-p50).	arsenite	52-60	tumor protein p53	Homo sapiens	69-72
23396362-3	2014	We found that the deletion of p50 (p50-/-) impaired arsenite-induced p53 protein expression, which could be restored after reconstitutive expression of HA-p50 in p50-/- cells, p50-/-(Ad-HA-p50).	arsenite	52-60	nuclear factor kappa B subunit 1	Homo sapiens	35-38
23396362-3	2014	We found that the deletion of p50 (p50-/-) impaired arsenite-induced p53 protein expression, which could be restored after reconstitutive expression of HA-p50 in p50-/- cells, p50-/-(Ad-HA-p50).	arsenite	52-60	nuclear factor kappa B subunit 1	Homo sapiens	35-38
23396362-3	2014	We found that the deletion of p50 (p50-/-) impaired arsenite-induced p53 protein expression, which could be restored after reconstitutive expression of HA-p50 in p50-/- cells, p50-/-(Ad-HA-p50).	arsenite	52-60	nuclear factor kappa B subunit 1	Homo sapiens	35-38
23396362-3	2014	We found that the deletion of p50 (p50-/-) impaired arsenite-induced p53 protein expression, which could be restored after reconstitutive expression of HA-p50 in p50-/- cells, p50-/-(Ad-HA-p50).	arsenite	52-60	nuclear factor kappa B subunit 1	Homo sapiens	35-38
23957350-9	2014	The MDT-15 interacting nuclear hormone receptor, NHR-64, is specifically required for tBOOH but not arsenite resistance, but NHR-64 is dispensable for the transcriptional response to tBOOH.	arsenite	100-108	Nuclear hormone receptor family member nhr-64	Caenorhabditis elegans	49-55
24284797-5	2014	A chemiluminescence-based NMD reporter assay system demonstrated that arsenite treatment inhibited NMD activity and increased SRSF3-PTC mRNA levels in the cytoplasm, facilitating translation of a truncated SRSF3 protein (SRSF3-TR) from SRSF3-PTC mRNA.	arsenite	70-78	serine and arginine rich splicing factor 3	Homo sapiens	206-211
24284797-5	2014	A chemiluminescence-based NMD reporter assay system demonstrated that arsenite treatment inhibited NMD activity and increased SRSF3-PTC mRNA levels in the cytoplasm, facilitating translation of a truncated SRSF3 protein (SRSF3-TR) from SRSF3-PTC mRNA.	arsenite	70-78	serine and arginine rich splicing factor 3	Homo sapiens	206-211
24284797-5	2014	A chemiluminescence-based NMD reporter assay system demonstrated that arsenite treatment inhibited NMD activity and increased SRSF3-PTC mRNA levels in the cytoplasm, facilitating translation of a truncated SRSF3 protein (SRSF3-TR) from SRSF3-PTC mRNA.	arsenite	70-78	serine and arginine rich splicing factor 3	Homo sapiens	206-211
24284797-9	2014	Interestingly, treatment of HCT116 cells with a small interference RNA specifically targeting SRSF3-PTC mRNA significantly attenuated arsenite-stimulated induction of c-JUN protein, its binding activity to the AP-1 binding site (-126 to 120 bp) in the interleukin (IL)-8 gene promoter, and AP-1 promoter activity, resulting in significant reduction of arsenite-stimulated IL-8 production.	arsenite	134-142	serine and arginine rich splicing factor 3	Homo sapiens	94-99
24284797-9	2014	Interestingly, treatment of HCT116 cells with a small interference RNA specifically targeting SRSF3-PTC mRNA significantly attenuated arsenite-stimulated induction of c-JUN protein, its binding activity to the AP-1 binding site (-126 to 120 bp) in the interleukin (IL)-8 gene promoter, and AP-1 promoter activity, resulting in significant reduction of arsenite-stimulated IL-8 production.	arsenite	134-142	C-X-C motif chemokine ligand 8	Homo sapiens	252-270
24284797-9	2014	Interestingly, treatment of HCT116 cells with a small interference RNA specifically targeting SRSF3-PTC mRNA significantly attenuated arsenite-stimulated induction of c-JUN protein, its binding activity to the AP-1 binding site (-126 to 120 bp) in the interleukin (IL)-8 gene promoter, and AP-1 promoter activity, resulting in significant reduction of arsenite-stimulated IL-8 production.	arsenite	134-142	C-X-C motif chemokine ligand 8	Homo sapiens	372-376
24284797-9	2014	Interestingly, treatment of HCT116 cells with a small interference RNA specifically targeting SRSF3-PTC mRNA significantly attenuated arsenite-stimulated induction of c-JUN protein, its binding activity to the AP-1 binding site (-126 to 120 bp) in the interleukin (IL)-8 gene promoter, and AP-1 promoter activity, resulting in significant reduction of arsenite-stimulated IL-8 production.	arsenite	352-360	serine and arginine rich splicing factor 3	Homo sapiens	94-99
24457827-2	2014	Here we discovered a novel biological function of p50 as a regulator of oncogenic c-Myc protein degradation upon arsenite treatment in a NF-kappaB transcriptional-independent mechanism.	arsenite	113-121	nuclear factor kappa B subunit 1	Homo sapiens	50-53
24184208-3	2014	However, quantitative image analysis of JNK1 localization following exposure of cells to either arsenite or hyperosmotic stress did not indicate its nuclear accumulation.	arsenite	96-104	mitogen-activated protein kinase 8	Homo sapiens	40-44
24184208-7	2014	In contrast, arsenite exposure which did not alter the initial rates of nuclear accumulation of GFP, GFP-T-antigen or GFP-JNK1, decreased the t1/2 for nuclear accumulation of both GFP and GFP-JNK1.	arsenite	13-21	mitogen-activated protein kinase 8	Homo sapiens	192-196
24270004-6	2014	Melanocytes were more resistant to arsenite and UVR stimulation of superoxide production than keratinocytes, but the concentration of arsenite necessary to inhibit the activity of the DNA repair protein poly(ADP-ribose)polymerase and enhance retention of UVR-induced DNA damage was essentially equivalent in both cell types.	arsenite	134-142	poly(ADP-ribose) polymerase 1	Homo sapiens	203-229
24457827-3	2014	Our results found that p50 was crucial for c-Myc protein induction following arsenite treatment by using specific knockdown and deletion of p50 in its normal expressed cells as well as reconstituting expression of p50 in its deficient cells.	arsenite	77-85	nuclear factor kappa B subunit 1	Homo sapiens	23-26
24457827-2	2014	Here we discovered a novel biological function of p50 as a regulator of oncogenic c-Myc protein degradation upon arsenite treatment in a NF-kappaB transcriptional-independent mechanism.	arsenite	113-121	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	82-87
24457827-3	2014	Our results found that p50 was crucial for c-Myc protein induction following arsenite treatment by using specific knockdown and deletion of p50 in its normal expressed cells as well as reconstituting expression of p50 in its deficient cells.	arsenite	77-85	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	43-48
24457827-3	2014	Our results found that p50 was crucial for c-Myc protein induction following arsenite treatment by using specific knockdown and deletion of p50 in its normal expressed cells as well as reconstituting expression of p50 in its deficient cells.	arsenite	77-85	nuclear factor kappa B subunit 1	Homo sapiens	140-143
24457827-3	2014	Our results found that p50 was crucial for c-Myc protein induction following arsenite treatment by using specific knockdown and deletion of p50 in its normal expressed cells as well as reconstituting expression of p50 in its deficient cells.	arsenite	77-85	nuclear factor kappa B subunit 1	Homo sapiens	140-143
24275069-0	2014	Arsenite binding-induced zinc loss from PARP-1 is equivalent to zinc deficiency in reducing PARP-1 activity, leading to inhibition of DNA repair.	arsenite	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	40-46
24457827-6	2014	FBW7 was profoundly upregulated in p50-deficient cells in comparison to that in p50 intact cells, whereas knockdown of FBW7 in p50-/- cells restored arsenite-induced c-Myc protein accumulation, assuring that FBW7 up-regulation was responsible for defect of c-Myc protein expression in p50-/- cells.	arsenite	149-157	F-box and WD repeat domain containing 7	Homo sapiens	119-123
24457827-6	2014	FBW7 was profoundly upregulated in p50-deficient cells in comparison to that in p50 intact cells, whereas knockdown of FBW7 in p50-/- cells restored arsenite-induced c-Myc protein accumulation, assuring that FBW7 up-regulation was responsible for defect of c-Myc protein expression in p50-/- cells.	arsenite	149-157	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	166-171
24457827-6	2014	FBW7 was profoundly upregulated in p50-deficient cells in comparison to that in p50 intact cells, whereas knockdown of FBW7 in p50-/- cells restored arsenite-induced c-Myc protein accumulation, assuring that FBW7 up-regulation was responsible for defect of c-Myc protein expression in p50-/- cells.	arsenite	149-157	F-box and WD repeat domain containing 7	Homo sapiens	119-123
24457827-6	2014	FBW7 was profoundly upregulated in p50-deficient cells in comparison to that in p50 intact cells, whereas knockdown of FBW7 in p50-/- cells restored arsenite-induced c-Myc protein accumulation, assuring that FBW7 up-regulation was responsible for defect of c-Myc protein expression in p50-/- cells.	arsenite	149-157	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	257-262
24333349-0	2014	In vivo mutagenicity of arsenite in the livers of gpt delta transgenic mice.	arsenite	24-32	glutamic pyruvic transaminase, soluble	Mus musculus	50-53
24333349-2	2014	The aim of this study was to assess the in vivo mutagenicity of arsenite in C57BL/6J gpt delta mice.	arsenite	64-72	glutamic pyruvic transaminase, soluble	Mus musculus	85-88
24333349-4	2014	The gpt mutation assays showed a significant increase in mutation frequency in the liver following arsenite exposure.	arsenite	99-107	glutamic pyruvic transaminase, soluble	Mus musculus	4-7
24188932-5	2014	Arsenite treatment inhibited HIF-1alpha hydroxylation by prolyl hydroxylases (PHDs) and increased HIF-1alpha stabilization, but did not affect HIF-1alpha mRNA expression and Akt activation.	arsenite	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	29-39
24188932-5	2014	Arsenite treatment inhibited HIF-1alpha hydroxylation by prolyl hydroxylases (PHDs) and increased HIF-1alpha stabilization, but did not affect HIF-1alpha mRNA expression and Akt activation.	arsenite	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	98-108
24188932-5	2014	Arsenite treatment inhibited HIF-1alpha hydroxylation by prolyl hydroxylases (PHDs) and increased HIF-1alpha stabilization, but did not affect HIF-1alpha mRNA expression and Akt activation.	arsenite	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	98-108
24302736-4	2014	STMN was phosphorylated on Ser-38 and Ser-63 in response to hyperosmolarity, heat shock, and arsenite treatment but rapidly dephosphorylated after oxidative stress treatment.	arsenite	93-101	stathmin 1	Homo sapiens	0-4
24188932-0	2014	NADPH oxidase-mitochondria axis-derived ROS mediate arsenite-induced HIF-1alpha stabilization by inhibiting prolyl hydroxylases activity.	arsenite	52-60	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-79
24275069-0	2014	Arsenite binding-induced zinc loss from PARP-1 is equivalent to zinc deficiency in reducing PARP-1 activity, leading to inhibition of DNA repair.	arsenite	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	92-98
24275069-4	2014	Since cellular poly(ADP-ribosyl)ation capacity has been positively correlated with zinc status in cells, we hypothesize that arsenite binding-induced zinc loss from PARP-1 is equivalent to zinc deficiency in reducing PARP-1 activity, leading to inhibition of DNA repair.	arsenite	125-133	poly(ADP-ribose) polymerase 1	Homo sapiens	165-171
24275069-4	2014	Since cellular poly(ADP-ribosyl)ation capacity has been positively correlated with zinc status in cells, we hypothesize that arsenite binding-induced zinc loss from PARP-1 is equivalent to zinc deficiency in reducing PARP-1 activity, leading to inhibition of DNA repair.	arsenite	125-133	poly(ADP-ribose) polymerase 1	Homo sapiens	217-223
24275069-5	2014	To test this hypothesis, we compared the effects of arsenite exposure with zinc deficiency, created by using the membrane-permeable zinc chelator TPEN, on 8-OHdG formation, PARP-1 activity and zinc binding to PARP-1 in HaCat cells.	arsenite	52-60	poly(ADP-ribose) polymerase 1	Homo sapiens	209-215
24275069-6	2014	Our results show that arsenite exposure and zinc deficiency had similar effects on PARP-1 protein, whereas supplemental zinc reversed these effects.	arsenite	22-30	poly(ADP-ribose) polymerase 1	Homo sapiens	83-89
24275069-8	2014	We found that arsenite binding as well as zinc loss altered the conformation of zinc finger structure which functionally leads to PARP-1 inhibition.	arsenite	14-22	poly(ADP-ribose) polymerase 1	Homo sapiens	130-136
24275069-9	2014	These findings suggest that arsenite binding to PARP-1 protein created similar adverse biological effects as zinc deficiency, which establishes the molecular mechanism for zinc supplementation as a potentially effective treatment to reverse the detrimental outcomes of arsenic exposure.	arsenite	28-36	poly(ADP-ribose) polymerase 1	Homo sapiens	48-54
25087952-4	2014	The exposure to arsenite increased O-GlcNAcylation and Hsp 70 levels in HeLa cells.	arsenite	16-24	heat shock protein family A (Hsp70) member 4	Homo sapiens	55-61
25087952-5	2014	However, the pre-treatment with PUGNAc or GlcN, which enhanced O-GlcNAcylation levels, decreased the arsenite-induced expression of Hsp 70.	arsenite	101-109	heat shock protein family A (Hsp70) member 4	Homo sapiens	132-138
25087952-8	2014	Finally, Hsp 70 mRNA expression was induced by arsenite, whereas the addition of PUGNAc slightly suppressed its induction.	arsenite	47-55	heat shock protein family A (Hsp70) member 4	Homo sapiens	9-15
25087952-9	2014	These results indicate that O-GlcNAcylation is related to arsenite-induced Hsp 70 expression, and demonstrated that hyper-O-GlcNAcylation inhibited the induction of Hsp 70 via transcriptional factors instead of HSF1.	arsenite	58-66	heat shock protein family A (Hsp70) member 4	Homo sapiens	75-81
25087952-9	2014	These results indicate that O-GlcNAcylation is related to arsenite-induced Hsp 70 expression, and demonstrated that hyper-O-GlcNAcylation inhibited the induction of Hsp 70 via transcriptional factors instead of HSF1.	arsenite	58-66	heat shock protein family A (Hsp70) member 4	Homo sapiens	165-171
25087952-9	2014	These results indicate that O-GlcNAcylation is related to arsenite-induced Hsp 70 expression, and demonstrated that hyper-O-GlcNAcylation inhibited the induction of Hsp 70 via transcriptional factors instead of HSF1.	arsenite	58-66	heat shock transcription factor 1	Homo sapiens	211-215
25200073-4	2014	SRP9/14, but not SRP, localizes to SGs following arsenite or hippuristanol treatment.	arsenite	49-57	signal recognition particle 9	Homo sapiens	0-4
24801890-6	2014	We further demonstrated that on acute exposure to arsenite, p21(waf1/Cip1) is upregulated and Notch1 downmodulated, whereas on chronic exposure to arsenite, malignant progression of arsenite-treated keratinocytes cells was accompanied by regained expression and activity of Notch1.	arsenite	147-155	notch receptor 1	Homo sapiens	274-280
24801890-6	2014	We further demonstrated that on acute exposure to arsenite, p21(waf1/Cip1) is upregulated and Notch1 downmodulated, whereas on chronic exposure to arsenite, malignant progression of arsenite-treated keratinocytes cells was accompanied by regained expression and activity of Notch1.	arsenite	147-155	cyclin dependent kinase inhibitor 1A	Homo sapiens	60-63
24801890-6	2014	We further demonstrated that on acute exposure to arsenite, p21(waf1/Cip1) is upregulated and Notch1 downmodulated, whereas on chronic exposure to arsenite, malignant progression of arsenite-treated keratinocytes cells was accompanied by regained expression and activity of Notch1.	arsenite	147-155	notch receptor 1	Homo sapiens	274-280
24801890-7	2014	Notch1 activity in arsenite-transformed keratinocytes inhibits arsenite-induced upregulation of p21(waf1/Cip1) by sustaining c-myc expression.	arsenite	19-27	notch receptor 1	Homo sapiens	0-6
24801890-7	2014	Notch1 activity in arsenite-transformed keratinocytes inhibits arsenite-induced upregulation of p21(waf1/Cip1) by sustaining c-myc expression.	arsenite	19-27	cyclin dependent kinase inhibitor 1A	Homo sapiens	96-109
24801890-7	2014	Notch1 activity in arsenite-transformed keratinocytes inhibits arsenite-induced upregulation of p21(waf1/Cip1) by sustaining c-myc expression.	arsenite	19-27	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	125-130
24801890-10	2014	Our results not only demonstrate that sustained Notch1 expression is at least one key event implicated in the arsenite human skin carcinogenic effect, but also may provide mechanistic insights into the molecular aspects that determine whether Notch signaling will be either oncogenic or tumor suppressive.	arsenite	110-118	notch receptor 1	Homo sapiens	48-54
24801890-10	2014	Our results not only demonstrate that sustained Notch1 expression is at least one key event implicated in the arsenite human skin carcinogenic effect, but also may provide mechanistic insights into the molecular aspects that determine whether Notch signaling will be either oncogenic or tumor suppressive.	arsenite	110-118	notch receptor 1	Homo sapiens	48-53
24205981-3	2014	We also show that, after arsenite treatment, a proportion of full-length SERBP1 protein co-localizes with the typical stress granule marker T-cell intracellular antigen-1 in the cytoplasmic stress granules.	arsenite	25-33	SERPINE1 mRNA binding protein 1	Homo sapiens	73-79
24205981-4	2014	Truncated SERBP1 with an N-terminal, central RG or C-terminal deletion, or single-domain segments comprising the N-terminal, central or C-terminal region, were recruited to stress granules upon arsenite treatment but with reduced efficiency.	arsenite	194-202	SERPINE1 mRNA binding protein 1	Homo sapiens	10-16
24205981-5	2014	In addition, upon arsenite treatment, the localization of SERBP1 changed from a diffuse cytoplasmic localization to nuclear-dominant (concentrated in the nucleolus) A similar distribution was observed when cells were treated with the methylation inhibitor adenosine periodate, and was also detected for N- or C-terminal domain deletions and all three single-domain fragments even without stress induction.	arsenite	18-26	SERPINE1 mRNA binding protein 1	Homo sapiens	58-64
25436473-5	2014	The structural/functional impairment of dialyzed and centrifugally concentrated (6-8 kd cutoff) hepatic SOD1 via its important Cys modifications by H2O2/arsenite redox-stress and that protection by CS/2-mercaptoethanol are shown in in vitro/in situ studies paralleling the present Swiss-Model-generated rSOD1 structural data.	arsenite	153-161	superoxide dismutase 1	Rattus norvegicus	104-108
24858502-6	2014	Using the same experimental model, we found that maternal arsenite exposure increases the incidence of hepatic tumors caused by a somatic mutation of the C61A Ha-ras gene, which encodes an activated oncogenic Ha-ras protein.	arsenite	58-66	Harvey rat sarcoma virus oncogene	Mus musculus	159-165
24858502-6	2014	Using the same experimental model, we found that maternal arsenite exposure increases the incidence of hepatic tumors caused by a somatic mutation of the C61A Ha-ras gene, which encodes an activated oncogenic Ha-ras protein.	arsenite	58-66	Harvey rat sarcoma virus oncogene	Mus musculus	209-215
24801890-4	2014	We found that acute exposure to arsenite increases oxidative stress and inhibits proliferation of keratinocyte cells by upregulation of p21(waf1/Cip1).	arsenite	32-40	cyclin dependent kinase inhibitor 1A	Homo sapiens	136-149
24801890-5	2014	The necessity of p21(waf1/Cip1) for arsenite-induced cell death was demonstrated by targeted downregulation of p21(waf1/Cip1) by using RNA interference.	arsenite	36-44	cyclin dependent kinase inhibitor 1A	Homo sapiens	17-30
24801890-5	2014	The necessity of p21(waf1/Cip1) for arsenite-induced cell death was demonstrated by targeted downregulation of p21(waf1/Cip1) by using RNA interference.	arsenite	36-44	cyclin dependent kinase inhibitor 1A	Homo sapiens	111-124
24801890-6	2014	We further demonstrated that on acute exposure to arsenite, p21(waf1/Cip1) is upregulated and Notch1 downmodulated, whereas on chronic exposure to arsenite, malignant progression of arsenite-treated keratinocytes cells was accompanied by regained expression and activity of Notch1.	arsenite	50-58	cyclin dependent kinase inhibitor 1A	Homo sapiens	60-63
24801890-6	2014	We further demonstrated that on acute exposure to arsenite, p21(waf1/Cip1) is upregulated and Notch1 downmodulated, whereas on chronic exposure to arsenite, malignant progression of arsenite-treated keratinocytes cells was accompanied by regained expression and activity of Notch1.	arsenite	50-58	cyclin dependent kinase inhibitor 1A	Homo sapiens	64-68
24801890-6	2014	We further demonstrated that on acute exposure to arsenite, p21(waf1/Cip1) is upregulated and Notch1 downmodulated, whereas on chronic exposure to arsenite, malignant progression of arsenite-treated keratinocytes cells was accompanied by regained expression and activity of Notch1.	arsenite	50-58	cyclin dependent kinase inhibitor 1A	Homo sapiens	69-73
24801890-6	2014	We further demonstrated that on acute exposure to arsenite, p21(waf1/Cip1) is upregulated and Notch1 downmodulated, whereas on chronic exposure to arsenite, malignant progression of arsenite-treated keratinocytes cells was accompanied by regained expression and activity of Notch1.	arsenite	50-58	notch receptor 1	Homo sapiens	94-100
24801890-6	2014	We further demonstrated that on acute exposure to arsenite, p21(waf1/Cip1) is upregulated and Notch1 downmodulated, whereas on chronic exposure to arsenite, malignant progression of arsenite-treated keratinocytes cells was accompanied by regained expression and activity of Notch1.	arsenite	50-58	notch receptor 1	Homo sapiens	274-280
24801890-6	2014	We further demonstrated that on acute exposure to arsenite, p21(waf1/Cip1) is upregulated and Notch1 downmodulated, whereas on chronic exposure to arsenite, malignant progression of arsenite-treated keratinocytes cells was accompanied by regained expression and activity of Notch1.	arsenite	147-155	cyclin dependent kinase inhibitor 1A	Homo sapiens	60-63
24361376-1	2014	Arsenic(III)methyltransferase (AS3MT) has been demonstrated to be the key enzyme in the metabolism of arsenic as it catalyses the methylation of arsenite and monomethylarsonic acid (MMA) to form methylated arsenic species, which have higher toxic and genotoxic potential than the parent compounds.	arsenite	145-153	arsenite methyltransferase	Homo sapiens	31-36
24106086-3	2014	Here, we investigated the localization of human antigen R (HuR), an mRNA-stabilizing RNA-binding protein, in SGs following exposure to the stress agent arsenite.	arsenite	152-160	ELAV like RNA binding protein 1	Homo sapiens	59-62
24121501-4	2013	Here we characterize the Cuz1 protein (Cdc48-associated UBL/zinc finger protein-1), encoded by a previously uncharacterized arsenite-inducible gene in budding yeast.	arsenite	124-132	Cuz1p	Saccharomyces cerevisiae S288C	25-29
24121501-9	2013	Cuz1-proteasome interaction is strongly enhanced by exposure of cells to the environmental toxin arsenite, and in a proteasome mutant, loss of Cuz1 enhances arsenite sensitivity.	arsenite	157-165	Cuz1p	Saccharomyces cerevisiae S288C	143-147
24184494-0	2014	Knockdown of p66Shc by siRNA injection rescues arsenite-induced developmental retardation in mouse preimplantation embryos.	arsenite	47-55	src homology 2 domain-containing transforming protein C1	Mus musculus	13-19
24184494-4	2014	The arsenite-induced 2-cell arrests, along with a reduction in the levels of reactive oxygen species (ROS), were significantly inhibited and the number of embryos developing to morula stage concurrently increased upon p66(shc) siRNA microinjection.	arsenite	4-12	src homology 2 domain-containing transforming protein C1	Mus musculus	218-221
24184494-4	2014	The arsenite-induced 2-cell arrests, along with a reduction in the levels of reactive oxygen species (ROS), were significantly inhibited and the number of embryos developing to morula stage concurrently increased upon p66(shc) siRNA microinjection.	arsenite	4-12	src homology 2 domain-containing transforming protein C1	Mus musculus	222-225
24184494-5	2014	These findings indicate that knockdown of p66(shc) improves the developmental competence of arsenite-exposed embryos in vitro by increasing the resistance to oxidative stress.	arsenite	92-100	src homology 2 domain-containing transforming protein C1	Mus musculus	42-45
24184494-5	2014	These findings indicate that knockdown of p66(shc) improves the developmental competence of arsenite-exposed embryos in vitro by increasing the resistance to oxidative stress.	arsenite	92-100	src homology 2 domain-containing transforming protein C1	Mus musculus	46-49
24391030-4	2013	When cells were exposed to lower sodium arsenite for 24 h, the arsenite content of ARG1 gene-overexpressing cells decreased and arsenic efflux increased.	arsenite	40-48	arginase 1	Homo sapiens	83-87
24135626-0	2013	Effects of arsenic on modification of promyelocytic leukemia (PML): PML responds to low levels of arsenite.	arsenite	98-106	PML nuclear body scaffold	Homo sapiens	38-66
24135626-0	2013	Effects of arsenic on modification of promyelocytic leukemia (PML): PML responds to low levels of arsenite.	arsenite	98-106	PML nuclear body scaffold	Homo sapiens	62-65
24183723-6	2013	Indeed, DDX3 localized in the cytoplasmic foci P-bodies or stress granules under stress condition after the treatment with arsenite.	arsenite	123-131	DEAD-box helicase 3 X-linked	Homo sapiens	8-12
24121501-4	2013	Here we characterize the Cuz1 protein (Cdc48-associated UBL/zinc finger protein-1), encoded by a previously uncharacterized arsenite-inducible gene in budding yeast.	arsenite	124-132	AAA family ATPase CDC48	Saccharomyces cerevisiae S288C	39-44
24121501-9	2013	Cuz1-proteasome interaction is strongly enhanced by exposure of cells to the environmental toxin arsenite, and in a proteasome mutant, loss of Cuz1 enhances arsenite sensitivity.	arsenite	97-105	Cuz1p	Saccharomyces cerevisiae S288C	0-4
24121501-9	2013	Cuz1-proteasome interaction is strongly enhanced by exposure of cells to the environmental toxin arsenite, and in a proteasome mutant, loss of Cuz1 enhances arsenite sensitivity.	arsenite	157-165	Cuz1p	Saccharomyces cerevisiae S288C	0-4
24012885-0	2013	Angiogenesis, mediated by miR-21, is involved arsenite-induced carcinogenesis.	arsenite	46-54	microRNA 21	Homo sapiens	26-32
24004609-0	2013	Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells.	arsenite	0-8	interleukin 6	Homo sapiens	16-20
24004609-0	2013	Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells.	arsenite	0-8	signal transducer and activator of transcription 3	Homo sapiens	56-61
24004609-0	2013	Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells.	arsenite	0-8	microRNA 21	Homo sapiens	77-83
24004609-0	2013	Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells.	arsenite	0-8	IL2 inducible T cell kinase	Homo sapiens	122-125
24004609-2	2013	The present results showed that, evoked by arsenite, secretion of interleukin-6 (IL-6), a pro-inflammatory cytokine, led to the activation of STAT3, a transcription activator, and to increased levels of a microRNA, miR-21.	arsenite	43-51	interleukin 6	Homo sapiens	66-79
24004609-2	2013	The present results showed that, evoked by arsenite, secretion of interleukin-6 (IL-6), a pro-inflammatory cytokine, led to the activation of STAT3, a transcription activator, and to increased levels of a microRNA, miR-21.	arsenite	43-51	interleukin 6	Homo sapiens	81-85
24004609-2	2013	The present results showed that, evoked by arsenite, secretion of interleukin-6 (IL-6), a pro-inflammatory cytokine, led to the activation of STAT3, a transcription activator, and to increased levels of a microRNA, miR-21.	arsenite	43-51	signal transducer and activator of transcription 3	Homo sapiens	142-147
24004609-2	2013	The present results showed that, evoked by arsenite, secretion of interleukin-6 (IL-6), a pro-inflammatory cytokine, led to the activation of STAT3, a transcription activator, and to increased levels of a microRNA, miR-21.	arsenite	43-51	microRNA 21	Homo sapiens	215-221
24004609-4	2013	For human bronchial epithelial cells, cultured in the presence of anti-IL-6 antibody for 3days, the arsenite-induced EMT and malignant transformation were reversed.	arsenite	100-108	interleukin 6	Homo sapiens	71-75
24004609-4	2013	For human bronchial epithelial cells, cultured in the presence of anti-IL-6 antibody for 3days, the arsenite-induced EMT and malignant transformation were reversed.	arsenite	100-108	IL2 inducible T cell kinase	Homo sapiens	117-120
24004609-5	2013	Thus, IL-6, acting on STAT3 signaling, which up-regulates miR-21in an autocrine manner, contributes to the EMT induced by arsenite.	arsenite	122-130	interleukin 6	Homo sapiens	6-10
24004609-5	2013	Thus, IL-6, acting on STAT3 signaling, which up-regulates miR-21in an autocrine manner, contributes to the EMT induced by arsenite.	arsenite	122-130	signal transducer and activator of transcription 3	Homo sapiens	22-27
24004609-5	2013	Thus, IL-6, acting on STAT3 signaling, which up-regulates miR-21in an autocrine manner, contributes to the EMT induced by arsenite.	arsenite	122-130	microRNA 21	Homo sapiens	58-64
24004609-5	2013	Thus, IL-6, acting on STAT3 signaling, which up-regulates miR-21in an autocrine manner, contributes to the EMT induced by arsenite.	arsenite	122-130	IL2 inducible T cell kinase	Homo sapiens	107-110
24004609-6	2013	These data define a link from inflammation to EMT in the arsenite-induced malignant transformation of HBE cells.	arsenite	57-65	IL2 inducible T cell kinase	Homo sapiens	46-49
24214398-6	2013	5-OP levels were further increased by the addition of arsenite and GSH to the medium, indicating that GGCT2;1 participates in the cellular response to arsenic (As) via GSH degradation.	arsenite	54-62	ChaC-like family protein	Arabidopsis thaliana	102-109
24012885-4	2013	Tumors formed from human bronchial epithelial (HBE) cells transformed by arsenite developed new blood vessels, which were prevented by the knockdown of miR-21, and cultures of human umbilical vein endothelial cells (HUVEC) exposed to arsenite developed endothelial tubes, a characteristic of angiogenesis.	arsenite	73-81	microRNA 21	Homo sapiens	152-158
24012885-6	2013	Down-regulation of miR-21 in these cells inhibited the arsenite-induced increases of VEGF levels.	arsenite	55-63	microRNA 21	Homo sapiens	19-25
24012885-6	2013	Down-regulation of miR-21 in these cells inhibited the arsenite-induced increases of VEGF levels.	arsenite	55-63	vascular endothelial growth factor A	Homo sapiens	85-89
24012885-7	2013	Thus, we conclude that arsenite induces tumor angiogenesis through processes mediated by miR-21.	arsenite	23-31	microRNA 21	Homo sapiens	89-95
23968587-3	2013	In U87MG cell monolayers, we have previously shown that arsenite cytotoxicity significantly increases upon transient inhibition of lysosomal protease Cathepsin L (CatL).	arsenite	56-64	cathepsin L	Homo sapiens	150-161
23968587-8	2013	Arsenite cytotoxicity was enhanced by lower CatL activity, since similar cytotoxicity increase was also observed using the novel CatL inhibitor AT094.	arsenite	0-8	cathepsin L	Homo sapiens	44-48
23968587-8	2013	Arsenite cytotoxicity was enhanced by lower CatL activity, since similar cytotoxicity increase was also observed using the novel CatL inhibitor AT094.	arsenite	0-8	cathepsin L	Homo sapiens	129-133
23968587-9	2013	The results have significant translational impact, since stable CatL silencing would enable the application of lower systemic doses of arsenite to achieve the desired cytotoxic effects on GBMs in vivo.	arsenite	135-143	cathepsin L	Homo sapiens	64-68
23968587-3	2013	In U87MG cell monolayers, we have previously shown that arsenite cytotoxicity significantly increases upon transient inhibition of lysosomal protease Cathepsin L (CatL).	arsenite	56-64	cathepsin L	Homo sapiens	163-167
23968587-4	2013	As multicellular spheroids more closely represent in vivo tumours, we aimed to evaluate the impact of permanent CatL silencing on arsenite treatment in U87MG spheroids.	arsenite	130-138	cathepsin L	Homo sapiens	112-116
23968587-6	2013	By using metabolic- and cell viability assays, we demonstrated that long-term CatL silencing significantly increased arsenite cytotoxicity in U87MG spheroids.	arsenite	117-125	cathepsin L	Homo sapiens	78-82
23968587-7	2013	Silenced CatL also increased arsenite-mediated apoptosis in spheroids via elevated p53 expression, Bax/Bcl2 ratio and caspase 3/7 activity, though with lower efficacy than in monolayers.	arsenite	29-37	cathepsin L	Homo sapiens	9-13
23811328-4	2013	The results showed that, on acute or chronic exposure to arsenite, HBE cells over-expressed the pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-1beta (IL-1beta).	arsenite	57-65	interleukin 6	Homo sapiens	124-137
23811328-4	2013	The results showed that, on acute or chronic exposure to arsenite, HBE cells over-expressed the pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-1beta (IL-1beta).	arsenite	57-65	interleukin 6	Homo sapiens	139-143
23811328-0	2013	Involvement of HIF-2alpha-mediated inflammation in arsenite-induced transformation of human bronchial epithelial cells.	arsenite	51-59	endothelial PAS domain protein 1	Homo sapiens	15-25
23811328-4	2013	The results showed that, on acute or chronic exposure to arsenite, HBE cells over-expressed the pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-1beta (IL-1beta).	arsenite	57-65	C-X-C motif chemokine ligand 8	Homo sapiens	146-159
23811328-4	2013	The results showed that, on acute or chronic exposure to arsenite, HBE cells over-expressed the pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-1beta (IL-1beta).	arsenite	57-65	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
23811328-4	2013	The results showed that, on acute or chronic exposure to arsenite, HBE cells over-expressed the pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-1beta (IL-1beta).	arsenite	57-65	interleukin 1 beta	Homo sapiens	172-189
23811328-4	2013	The results showed that, on acute or chronic exposure to arsenite, HBE cells over-expressed the pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-1beta (IL-1beta).	arsenite	57-65	interleukin 1 beta	Homo sapiens	191-199
23811328-5	2013	The data also indicated that HIF-2alpha was involved in arsenite-induced inflammation.	arsenite	56-64	endothelial PAS domain protein 1	Homo sapiens	29-39
23811328-6	2013	Moreover, IL-6 and IL-8 were essential for the malignant progression of arsenite-transformed HBE cells.	arsenite	72-80	interleukin 6	Homo sapiens	10-14
23811328-6	2013	Moreover, IL-6 and IL-8 were essential for the malignant progression of arsenite-transformed HBE cells.	arsenite	72-80	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
23811328-7	2013	Thus, these experiments show that HIF-2alpha mediates arsenite-induced inflammation and that such inflammation is involved in arsenite-induced malignant transformation of HBE cells.	arsenite	54-62	endothelial PAS domain protein 1	Homo sapiens	34-44
23824679-9	2013	HO-1 siRNA transfection was employed to prevent arsenite-induced HO-1 elevation.	arsenite	48-56	heme oxygenase 1	Homo sapiens	65-69
23744399-3	2013	In addition, arsenite reduced mitochondria membrane potential (MMP) and decreased neurotrophic gene expressions such as n-myc downstream-regulated gene 4 (NDRG-4), brain-derived neurotrophic factor (BDNF) and sirtuin-1 (SIRT-1) in SH-SY5Y cells.	arsenite	13-21	NDRG family member 4	Homo sapiens	120-153
23744399-3	2013	In addition, arsenite reduced mitochondria membrane potential (MMP) and decreased neurotrophic gene expressions such as n-myc downstream-regulated gene 4 (NDRG-4), brain-derived neurotrophic factor (BDNF) and sirtuin-1 (SIRT-1) in SH-SY5Y cells.	arsenite	13-21	NDRG family member 4	Homo sapiens	155-161
23744399-3	2013	In addition, arsenite reduced mitochondria membrane potential (MMP) and decreased neurotrophic gene expressions such as n-myc downstream-regulated gene 4 (NDRG-4), brain-derived neurotrophic factor (BDNF) and sirtuin-1 (SIRT-1) in SH-SY5Y cells.	arsenite	13-21	brain derived neurotrophic factor	Homo sapiens	164-197
23744399-3	2013	In addition, arsenite reduced mitochondria membrane potential (MMP) and decreased neurotrophic gene expressions such as n-myc downstream-regulated gene 4 (NDRG-4), brain-derived neurotrophic factor (BDNF) and sirtuin-1 (SIRT-1) in SH-SY5Y cells.	arsenite	13-21	brain derived neurotrophic factor	Homo sapiens	199-203
23744399-3	2013	In addition, arsenite reduced mitochondria membrane potential (MMP) and decreased neurotrophic gene expressions such as n-myc downstream-regulated gene 4 (NDRG-4), brain-derived neurotrophic factor (BDNF) and sirtuin-1 (SIRT-1) in SH-SY5Y cells.	arsenite	13-21	sirtuin 1	Homo sapiens	209-218
23744399-3	2013	In addition, arsenite reduced mitochondria membrane potential (MMP) and decreased neurotrophic gene expressions such as n-myc downstream-regulated gene 4 (NDRG-4), brain-derived neurotrophic factor (BDNF) and sirtuin-1 (SIRT-1) in SH-SY5Y cells.	arsenite	13-21	sirtuin 1	Homo sapiens	220-226
23890198-8	2013	We also showed that arsenite increases mRNA and protein of p16(INK4a), an inhibitor of CDK4/6 that phosphorylates p130.	arsenite	20-28	cyclin dependent kinase inhibitor 2A	Mus musculus	63-68
23890198-8	2013	We also showed that arsenite increases mRNA and protein of p16(INK4a), an inhibitor of CDK4/6 that phosphorylates p130.	arsenite	20-28	cyclin-dependent kinase 4	Mus musculus	87-93
23890198-8	2013	We also showed that arsenite increases mRNA and protein of p16(INK4a), an inhibitor of CDK4/6 that phosphorylates p130.	arsenite	20-28	nucleolar and coiled-body phosphoprotein 1	Mus musculus	114-118
23890198-9	2013	Down-regulation of arsenite-induced p16(INK4a) by siRNA suppressed the p130 accumulation.	arsenite	19-27	cyclin dependent kinase inhibitor 2A	Mus musculus	36-39
23890198-9	2013	Down-regulation of arsenite-induced p16(INK4a) by siRNA suppressed the p130 accumulation.	arsenite	19-27	cyclin dependent kinase inhibitor 2A	Mus musculus	40-45
23890198-9	2013	Down-regulation of arsenite-induced p16(INK4a) by siRNA suppressed the p130 accumulation.	arsenite	19-27	nucleolar and coiled-body phosphoprotein 1	Mus musculus	71-75
23890198-10	2013	We propose a novel mechanism in which arsenite inhibits phosphorylation/ubiquitin-dependent proteasome degradation of p130 by inducing p16(INK4a) and the accumulated p130 causes cell cycle arrest with E2F4.	arsenite	38-46	nucleolar and coiled-body phosphoprotein 1	Mus musculus	118-122
23890198-10	2013	We propose a novel mechanism in which arsenite inhibits phosphorylation/ubiquitin-dependent proteasome degradation of p130 by inducing p16(INK4a) and the accumulated p130 causes cell cycle arrest with E2F4.	arsenite	38-46	cyclin dependent kinase inhibitor 2A	Mus musculus	135-138
23890198-10	2013	We propose a novel mechanism in which arsenite inhibits phosphorylation/ubiquitin-dependent proteasome degradation of p130 by inducing p16(INK4a) and the accumulated p130 causes cell cycle arrest with E2F4.	arsenite	38-46	cyclin dependent kinase inhibitor 2A	Mus musculus	139-144
23890198-10	2013	We propose a novel mechanism in which arsenite inhibits phosphorylation/ubiquitin-dependent proteasome degradation of p130 by inducing p16(INK4a) and the accumulated p130 causes cell cycle arrest with E2F4.	arsenite	38-46	nucleolar and coiled-body phosphoprotein 1	Mus musculus	166-170
23890198-10	2013	We propose a novel mechanism in which arsenite inhibits phosphorylation/ubiquitin-dependent proteasome degradation of p130 by inducing p16(INK4a) and the accumulated p130 causes cell cycle arrest with E2F4.	arsenite	38-46	E2F transcription factor 4	Mus musculus	201-205
23824679-0	2013	Role of HO-1 in the arsenite-induced neurotoxicity in primary cultured cortical neurons.	arsenite	20-28	heme oxygenase 1	Homo sapiens	8-12
23824679-1	2013	In the present study, the role of heme oxygenase (HO)-1 in sodium arsenite (arsenite)-induced neurotoxicity was investigated using primary cultured cortical neurons.	arsenite	66-74	heme oxygenase 1	Homo sapiens	34-55
23824679-3	2013	Furthermore, arsenite induced caspase 3 activation and decreased procaspase 12 levels, indicating that apoptosis is involved in the arsenite-induced neurotoxicity.	arsenite	13-21	caspase 3	Homo sapiens	30-39
23824679-5	2013	Western blot assay showed that arsenite significantly increased HO-1 levels, a redox-regulated protein.	arsenite	31-39	heme oxygenase 1	Homo sapiens	64-68
23824679-6	2013	Co-incubation with glutathione (10 mM) attenuated arsenite-induced HO-1 elevation and caspase 3 activation, suggesting that oxidative stress is involved in the arsenite-induced neurotoxicity.	arsenite	50-58	heme oxygenase 1	Homo sapiens	67-71
23824679-6	2013	Co-incubation with glutathione (10 mM) attenuated arsenite-induced HO-1 elevation and caspase 3 activation, suggesting that oxidative stress is involved in the arsenite-induced neurotoxicity.	arsenite	160-168	caspase 3	Homo sapiens	86-95
23824679-7	2013	The neurotoxic effects of inorganic arsenics were compared; arsenite was more potent than arsenate in inducing HO-1 expression and caspase 3 activation.	arsenite	60-68	heme oxygenase 1	Homo sapiens	111-115
23968725-4	2013	Arsenite-induced HIF-1alpha, VEGF and COX-2 expressions were decreased by PI3K inhibitors.	arsenite	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-27
23968725-4	2013	Arsenite-induced HIF-1alpha, VEGF and COX-2 expressions were decreased by PI3K inhibitors.	arsenite	0-8	vascular endothelial growth factor A	Homo sapiens	29-33
23968725-4	2013	Arsenite-induced HIF-1alpha, VEGF and COX-2 expressions were decreased by PI3K inhibitors.	arsenite	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	38-43
23968725-5	2013	Blockage of the ERK1/2, p38 and JNK down-regulated the VEGF level, while ERK1/2 and p38 inhibitors were more effective than JNK in attenuating arsenite-induced COX-2 expression.	arsenite	143-151	mitogen-activated protein kinase 3	Homo sapiens	16-22
23968725-5	2013	Blockage of the ERK1/2, p38 and JNK down-regulated the VEGF level, while ERK1/2 and p38 inhibitors were more effective than JNK in attenuating arsenite-induced COX-2 expression.	arsenite	143-151	mitogen-activated protein kinase 1	Homo sapiens	24-27
23968725-5	2013	Blockage of the ERK1/2, p38 and JNK down-regulated the VEGF level, while ERK1/2 and p38 inhibitors were more effective than JNK in attenuating arsenite-induced COX-2 expression.	arsenite	143-151	mitogen-activated protein kinase 8	Homo sapiens	32-35
23968725-5	2013	Blockage of the ERK1/2, p38 and JNK down-regulated the VEGF level, while ERK1/2 and p38 inhibitors were more effective than JNK in attenuating arsenite-induced COX-2 expression.	arsenite	143-151	vascular endothelial growth factor A	Homo sapiens	55-59
23968725-5	2013	Blockage of the ERK1/2, p38 and JNK down-regulated the VEGF level, while ERK1/2 and p38 inhibitors were more effective than JNK in attenuating arsenite-induced COX-2 expression.	arsenite	143-151	mitogen-activated protein kinase 3	Homo sapiens	73-79
23968725-5	2013	Blockage of the ERK1/2, p38 and JNK down-regulated the VEGF level, while ERK1/2 and p38 inhibitors were more effective than JNK in attenuating arsenite-induced COX-2 expression.	arsenite	143-151	mitogen-activated protein kinase 1	Homo sapiens	84-87
23968725-5	2013	Blockage of the ERK1/2, p38 and JNK down-regulated the VEGF level, while ERK1/2 and p38 inhibitors were more effective than JNK in attenuating arsenite-induced COX-2 expression.	arsenite	143-151	mitogen-activated protein kinase 8	Homo sapiens	124-127
23968725-5	2013	Blockage of the ERK1/2, p38 and JNK down-regulated the VEGF level, while ERK1/2 and p38 inhibitors were more effective than JNK in attenuating arsenite-induced COX-2 expression.	arsenite	143-151	prostaglandin-endoperoxide synthase 2	Homo sapiens	160-165
23968725-7	2013	It was found that superoxide (O2(-)) generation was involved in arsenite-induced the activation of MAPK and PI3K pathways, which led to the HIF-1alpha, COX-2 and VEGF overexpressions.	arsenite	64-72	mitogen-activated protein kinase 3	Homo sapiens	99-103
23968725-7	2013	It was found that superoxide (O2(-)) generation was involved in arsenite-induced the activation of MAPK and PI3K pathways, which led to the HIF-1alpha, COX-2 and VEGF overexpressions.	arsenite	64-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	140-150
23968725-7	2013	It was found that superoxide (O2(-)) generation was involved in arsenite-induced the activation of MAPK and PI3K pathways, which led to the HIF-1alpha, COX-2 and VEGF overexpressions.	arsenite	64-72	prostaglandin-endoperoxide synthase 2	Homo sapiens	152-157
23968725-7	2013	It was found that superoxide (O2(-)) generation was involved in arsenite-induced the activation of MAPK and PI3K pathways, which led to the HIF-1alpha, COX-2 and VEGF overexpressions.	arsenite	64-72	vascular endothelial growth factor A	Homo sapiens	162-166
23968725-8	2013	In conclusion, arsenite-induced COX-2, VEGF and HIF-1alpha expressions, mediated partially by reactive oxygen species (ROS), were regulated by MAPK and PI3K/AKT signaling pathways in human uroepithelial cells.	arsenite	15-23	prostaglandin-endoperoxide synthase 2	Homo sapiens	32-37
23968725-8	2013	In conclusion, arsenite-induced COX-2, VEGF and HIF-1alpha expressions, mediated partially by reactive oxygen species (ROS), were regulated by MAPK and PI3K/AKT signaling pathways in human uroepithelial cells.	arsenite	15-23	vascular endothelial growth factor A	Homo sapiens	39-43
23968725-8	2013	In conclusion, arsenite-induced COX-2, VEGF and HIF-1alpha expressions, mediated partially by reactive oxygen species (ROS), were regulated by MAPK and PI3K/AKT signaling pathways in human uroepithelial cells.	arsenite	15-23	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-58
23968725-8	2013	In conclusion, arsenite-induced COX-2, VEGF and HIF-1alpha expressions, mediated partially by reactive oxygen species (ROS), were regulated by MAPK and PI3K/AKT signaling pathways in human uroepithelial cells.	arsenite	15-23	mitogen-activated protein kinase 3	Homo sapiens	143-147
23968725-8	2013	In conclusion, arsenite-induced COX-2, VEGF and HIF-1alpha expressions, mediated partially by reactive oxygen species (ROS), were regulated by MAPK and PI3K/AKT signaling pathways in human uroepithelial cells.	arsenite	15-23	AKT serine/threonine kinase 1	Homo sapiens	157-160
23744399-4	2013	In parallel, taurine prevented cell cycle, restored MMP and reduced the intracellular ROS level, and taurine recovered NDRG-4, BDNF and SIRT-1 gene expressions in arsenite-treated SH-SY5Y cells while taurine alone has no effect on these parameters.	arsenite	163-171	NDRG family member 4	Homo sapiens	119-125
23744399-4	2013	In parallel, taurine prevented cell cycle, restored MMP and reduced the intracellular ROS level, and taurine recovered NDRG-4, BDNF and SIRT-1 gene expressions in arsenite-treated SH-SY5Y cells while taurine alone has no effect on these parameters.	arsenite	163-171	brain derived neurotrophic factor	Homo sapiens	127-131
23744399-4	2013	In parallel, taurine prevented cell cycle, restored MMP and reduced the intracellular ROS level, and taurine recovered NDRG-4, BDNF and SIRT-1 gene expressions in arsenite-treated SH-SY5Y cells while taurine alone has no effect on these parameters.	arsenite	163-171	sirtuin 1	Homo sapiens	136-142
23890198-4	2013	Arsenite exposure of A20 cells was showed to increase the protein level of p130, a RB family member, without changing the mRNA level.	arsenite	0-8	nucleolar and coiled-body phosphoprotein 1	Mus musculus	75-79
23890198-5	2013	Suppression of arsenite-induced p130 by siRNA reduced the G0/G1 phase, indicating that p130 accumulation is responsible for arsenite-induced G0/G1 arrest.	arsenite	15-23	nucleolar and coiled-body phosphoprotein 1	Mus musculus	32-36
23890198-5	2013	Suppression of arsenite-induced p130 by siRNA reduced the G0/G1 phase, indicating that p130 accumulation is responsible for arsenite-induced G0/G1 arrest.	arsenite	15-23	nucleolar and coiled-body phosphoprotein 1	Mus musculus	87-91
23890198-5	2013	Suppression of arsenite-induced p130 by siRNA reduced the G0/G1 phase, indicating that p130 accumulation is responsible for arsenite-induced G0/G1 arrest.	arsenite	124-132	nucleolar and coiled-body phosphoprotein 1	Mus musculus	32-36
23890198-5	2013	Suppression of arsenite-induced p130 by siRNA reduced the G0/G1 phase, indicating that p130 accumulation is responsible for arsenite-induced G0/G1 arrest.	arsenite	124-132	nucleolar and coiled-body phosphoprotein 1	Mus musculus	87-91
23890198-7	2013	Comparison by Western blotting of arsenite-induced p130 and p130 accumulated by a proteasome inhibitor suggested that arsenite-induced p130 is hypophosphorylated and hypoubiquitinated and refractory to proteasome-dependent degradation.	arsenite	34-42	nucleolar and coiled-body phosphoprotein 1	Mus musculus	51-55
23890198-7	2013	Comparison by Western blotting of arsenite-induced p130 and p130 accumulated by a proteasome inhibitor suggested that arsenite-induced p130 is hypophosphorylated and hypoubiquitinated and refractory to proteasome-dependent degradation.	arsenite	118-126	nucleolar and coiled-body phosphoprotein 1	Mus musculus	51-55
23890198-7	2013	Comparison by Western blotting of arsenite-induced p130 and p130 accumulated by a proteasome inhibitor suggested that arsenite-induced p130 is hypophosphorylated and hypoubiquitinated and refractory to proteasome-dependent degradation.	arsenite	118-126	nucleolar and coiled-body phosphoprotein 1	Mus musculus	60-64
23890198-7	2013	Comparison by Western blotting of arsenite-induced p130 and p130 accumulated by a proteasome inhibitor suggested that arsenite-induced p130 is hypophosphorylated and hypoubiquitinated and refractory to proteasome-dependent degradation.	arsenite	118-126	nucleolar and coiled-body phosphoprotein 1	Mus musculus	60-64
23890198-8	2013	We also showed that arsenite increases mRNA and protein of p16(INK4a), an inhibitor of CDK4/6 that phosphorylates p130.	arsenite	20-28	cyclin dependent kinase inhibitor 2A	Mus musculus	59-62
23824679-7	2013	The neurotoxic effects of inorganic arsenics were compared; arsenite was more potent than arsenate in inducing HO-1 expression and caspase 3 activation.	arsenite	60-68	caspase 3	Homo sapiens	131-140
23824679-9	2013	HO-1 siRNA transfection was employed to prevent arsenite-induced HO-1 elevation.	arsenite	48-56	heme oxygenase 1	Homo sapiens	0-4
23824679-10	2013	At the same time, arsenite-induced caspase 3 activation and neuronal death were attenuated in the HO-1 siRNA-transfected cells.	arsenite	18-26	caspase 3	Homo sapiens	35-44
23824679-10	2013	At the same time, arsenite-induced caspase 3 activation and neuronal death were attenuated in the HO-1 siRNA-transfected cells.	arsenite	18-26	heme oxygenase 1	Homo sapiens	98-102
23824679-11	2013	Taken together, HO-1 appears to be neuroprotective in the arsenite-induced neurotoxicity in primary cultured cortical neurons.	arsenite	58-66	heme oxygenase 1	Homo sapiens	16-20
23824679-12	2013	In addition to antioxidants, HO-1 elevation may be a neuroprotective strategy for arsenite-induced neurotoxicity.	arsenite	82-90	heme oxygenase 1	Homo sapiens	29-33
23732083-7	2013	The expression of EMT genes including TGFbeta2, TGFbeta receptor-3, Snail, and Has-2 are decreased in a dose-dependent manner following exposure to arsenite.	arsenite	148-156	transforming growth factor, beta 2	Mus musculus	38-46
23489261-8	2013	Compared to the WT, the mutant aux1 was significantly more sensitive to high-temperature stress and salinity, also suggesting auxin transport influences a common element shared by plant tolerance to arsenite, salinity and high-temperature stress.	arsenite	199-207	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	31-35
23732083-7	2013	The expression of EMT genes including TGFbeta2, TGFbeta receptor-3, Snail, and Has-2 are decreased in a dose-dependent manner following exposure to arsenite.	arsenite	148-156	transforming growth factor, beta 1	Mus musculus	38-45
23732083-7	2013	The expression of EMT genes including TGFbeta2, TGFbeta receptor-3, Snail, and Has-2 are decreased in a dose-dependent manner following exposure to arsenite.	arsenite	148-156	snail family zinc finger 1	Mus musculus	68-73
23732083-7	2013	The expression of EMT genes including TGFbeta2, TGFbeta receptor-3, Snail, and Has-2 are decreased in a dose-dependent manner following exposure to arsenite.	arsenite	148-156	hyaluronan synthase 2	Mus musculus	79-84
23732083-8	2013	TGFbeta2 cell signaling is abrogated as detected by decreases in phosphorylated Smad2/3 when cells are exposed to 1.34muM arsenite.	arsenite	122-130	transforming growth factor, beta 2	Mus musculus	0-8
23732083-8	2013	TGFbeta2 cell signaling is abrogated as detected by decreases in phosphorylated Smad2/3 when cells are exposed to 1.34muM arsenite.	arsenite	122-130	SMAD family member 2	Mus musculus	80-85
23832056-5	2013	Arsenite sorption on both WTRs increased with increasing pH up to circum-neutral pHs and then decreased at higher pHs, whereas As(V) sorption decreased steadily with increasing pH.	arsenite	0-8	WTRS	Homo sapiens	26-30
23639288-0	2013	p27 suppresses cyclooxygenase-2 expression by inhibiting p38beta and p38delta-mediated CREB phosphorylation upon arsenite exposure.	arsenite	113-121	interferon alpha inducible protein 27	Homo sapiens	0-3
23811142-0	2013	Maternal and early life arsenite exposure impairs neurodevelopment and increases the expression of PSA-NCAM in hippocampus of rat offspring.	arsenite	24-32	neural cell adhesion molecule 1	Rattus norvegicus	99-107
23811142-4	2013	The present study aimed at investigating the effects of maternal and early life arsenite exposure on NCAM and PSA-NCAM in rat offspring.	arsenite	80-88	neural cell adhesion molecule 1	Rattus norvegicus	101-105
23811142-4	2013	The present study aimed at investigating the effects of maternal and early life arsenite exposure on NCAM and PSA-NCAM in rat offspring.	arsenite	80-88	neural cell adhesion molecule 1	Rattus norvegicus	110-118
23811142-9	2013	Neurons and capillaries presented pathological changes and the expression of NCAM, PSA-NCAM, STX and PST were up-regulated in hippocampus of rat offspring exposed to arsenite.	arsenite	166-174	neural cell adhesion molecule 1	Rattus norvegicus	77-81
23811142-9	2013	Neurons and capillaries presented pathological changes and the expression of NCAM, PSA-NCAM, STX and PST were up-regulated in hippocampus of rat offspring exposed to arsenite.	arsenite	166-174	neural cell adhesion molecule 1	Rattus norvegicus	83-91
23811142-9	2013	Neurons and capillaries presented pathological changes and the expression of NCAM, PSA-NCAM, STX and PST were up-regulated in hippocampus of rat offspring exposed to arsenite.	arsenite	166-174	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Rattus norvegicus	93-96
23811142-10	2013	These results indicated that maternal arsenite exposure increases the expression of PSA-NCAM, NCAM and polysialyltransferases in hippocampus of rat offspring on postnatal day (PND) 21 and PND120, which might contribute to the impaired neurodevelopment following arsenite exposure.	arsenite	38-46	neural cell adhesion molecule 1	Rattus norvegicus	84-92
23811142-10	2013	These results indicated that maternal arsenite exposure increases the expression of PSA-NCAM, NCAM and polysialyltransferases in hippocampus of rat offspring on postnatal day (PND) 21 and PND120, which might contribute to the impaired neurodevelopment following arsenite exposure.	arsenite	38-46	neural cell adhesion molecule 1	Rattus norvegicus	88-92
23639288-0	2013	p27 suppresses cyclooxygenase-2 expression by inhibiting p38beta and p38delta-mediated CREB phosphorylation upon arsenite exposure.	arsenite	113-121	prostaglandin-endoperoxide synthase 2	Homo sapiens	15-31
23639288-0	2013	p27 suppresses cyclooxygenase-2 expression by inhibiting p38beta and p38delta-mediated CREB phosphorylation upon arsenite exposure.	arsenite	113-121	mitogen-activated protein kinase 13	Homo sapiens	69-77
23639288-0	2013	p27 suppresses cyclooxygenase-2 expression by inhibiting p38beta and p38delta-mediated CREB phosphorylation upon arsenite exposure.	arsenite	113-121	cAMP responsive element binding protein 1	Homo sapiens	87-91
23639288-2	2013	Our most recent studies demonstrate that upon arsenite exposure, p27 suppresses Hsp27 and Hsp70 expressions through the JNK2/c-Jun- and HSF-1-dependent pathways, suggesting a novel molecular mechanism underlying the tumor suppressive function of p27 in a CDK-independent manner.	arsenite	46-54	interferon alpha inducible protein 27	Homo sapiens	65-68
23639288-2	2013	Our most recent studies demonstrate that upon arsenite exposure, p27 suppresses Hsp27 and Hsp70 expressions through the JNK2/c-Jun- and HSF-1-dependent pathways, suggesting a novel molecular mechanism underlying the tumor suppressive function of p27 in a CDK-independent manner.	arsenite	46-54	heat shock protein family B (small) member 1	Homo sapiens	80-85
23639288-2	2013	Our most recent studies demonstrate that upon arsenite exposure, p27 suppresses Hsp27 and Hsp70 expressions through the JNK2/c-Jun- and HSF-1-dependent pathways, suggesting a novel molecular mechanism underlying the tumor suppressive function of p27 in a CDK-independent manner.	arsenite	46-54	heat shock protein family A (Hsp70) member 4	Homo sapiens	90-95
23639288-2	2013	Our most recent studies demonstrate that upon arsenite exposure, p27 suppresses Hsp27 and Hsp70 expressions through the JNK2/c-Jun- and HSF-1-dependent pathways, suggesting a novel molecular mechanism underlying the tumor suppressive function of p27 in a CDK-independent manner.	arsenite	46-54	mitogen-activated protein kinase 9	Homo sapiens	120-124
23639288-2	2013	Our most recent studies demonstrate that upon arsenite exposure, p27 suppresses Hsp27 and Hsp70 expressions through the JNK2/c-Jun- and HSF-1-dependent pathways, suggesting a novel molecular mechanism underlying the tumor suppressive function of p27 in a CDK-independent manner.	arsenite	46-54	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	125-130
23639288-2	2013	Our most recent studies demonstrate that upon arsenite exposure, p27 suppresses Hsp27 and Hsp70 expressions through the JNK2/c-Jun- and HSF-1-dependent pathways, suggesting a novel molecular mechanism underlying the tumor suppressive function of p27 in a CDK-independent manner.	arsenite	46-54	heat shock transcription factor 1	Homo sapiens	136-141
23639288-2	2013	Our most recent studies demonstrate that upon arsenite exposure, p27 suppresses Hsp27 and Hsp70 expressions through the JNK2/c-Jun- and HSF-1-dependent pathways, suggesting a novel molecular mechanism underlying the tumor suppressive function of p27 in a CDK-independent manner.	arsenite	46-54	interferon alpha inducible protein 27	Homo sapiens	82-85
23721794-6	2013	Conjugation of scFv(CD44v6) with mal-PEG-PDLLA (scFv-As-NPs) enabled more efficient delivery of As and exhibited higher cytotoxic activity than non-targeted ones (As-NPs) in human pancreatic cancer cells PANC-1.	arsenite	53-55	immunglobulin heavy chain variable region	Homo sapiens	15-19
23603037-6	2013	Overall results suggested that both insulin and NIn improved mitochondrial functioning in arsenite-intoxicated L6 cells, NIn showing better effects at a much lower dose (at nearly 10-fold decreased dose) than that produced by insulin.	arsenite	90-98	insulin	Homo sapiens	36-43
24351558-0	2013	[Chronic combined effects of fluoride and arsenite on the Runx2 and downstream related factors of bone metabolism in rats].	arsenite	42-50	RUNX family transcription factor 2	Rattus norvegicus	58-63
24351558-11	2013	There was negative correlation between arsenite gavage concentration with Runx2 level (r = -0.527, P < 0.05) and was no correlation between arsenite gavage concentration with MMP-9, RANKL,Osterix level (P > 0.05).	arsenite	39-47	RUNX family transcription factor 2	Rattus norvegicus	74-79
24351558-12	2013	There was interaction between fluoride and arsenite to Runx2, MMP-9, RANKL,Osterix (F = 3.88, 15.66, 2.92, 6.42, respectively, P = 0.01, <0.01, 0.031, <0.01, respectively).	arsenite	43-51	RUNX family transcription factor 2	Rattus norvegicus	55-60
24351558-12	2013	There was interaction between fluoride and arsenite to Runx2, MMP-9, RANKL,Osterix (F = 3.88, 15.66, 2.92, 6.42, respectively, P = 0.01, <0.01, 0.031, <0.01, respectively).	arsenite	43-51	Sp7 transcription factor	Rattus norvegicus	75-82
23692256-7	2013	Furthermore, siRNA-mediated p32 knockdown resulted in differential stress-dependent effects on cell death, with enhanced cell death observed in the presence of hyperosmotic stress or cisplatin treatment, but decreased cell death in the presence of arsenite.	arsenite	248-256	complement C1q binding protein	Homo sapiens	28-31
23721794-6	2013	Conjugation of scFv(CD44v6) with mal-PEG-PDLLA (scFv-As-NPs) enabled more efficient delivery of As and exhibited higher cytotoxic activity than non-targeted ones (As-NPs) in human pancreatic cancer cells PANC-1.	arsenite	53-55	immunglobulin heavy chain variable region	Homo sapiens	48-52
23721794-9	2013	In animal tests, scFv-As-NPs were found to greatly increase accumulation of drug in tumor site and potentiate the efficacy of As in inhibiting tumor growth owing to the enhanced cell apoptosis.	arsenite	22-24	immunglobulin heavy chain variable region	Homo sapiens	17-21
23602911-6	2013	Furthermore, the effects of arsenite on PARP-1 activity, DNA binding, and zinc content were partially reversed by the antioxidant ascorbic acid, catalase, and the NOS inhibitor, aminoguanidine.	arsenite	28-36	poly(ADP-ribose) polymerase 1	Homo sapiens	40-46
23602911-7	2013	Most importantly, arsenite incubation with purified PARP-1 protein in vitro did not alter PARP-1 activity or DNA-binding ability, whereas hydrogen peroxide or NONOate retained PARP-1 inhibitory activity.	arsenite	18-26	poly(ADP-ribose) polymerase 1	Homo sapiens	52-58
23602911-0	2013	Arsenite-induced ROS/RNS generation causes zinc loss and inhibits the activity of poly(ADP-ribose) polymerase-1.	arsenite	0-8	FAM20C golgi associated secretory pathway kinase	Homo sapiens	21-24
23602911-8	2013	These results strongly suggest that cellular generation of ROS/RNS plays an important role in arsenite inhibition of PARP-1 activity, leading to the loss of PARP-1 DNA-binding ability and enzymatic activity.	arsenite	94-102	FAM20C golgi associated secretory pathway kinase	Homo sapiens	63-66
23602911-0	2013	Arsenite-induced ROS/RNS generation causes zinc loss and inhibits the activity of poly(ADP-ribose) polymerase-1.	arsenite	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	82-111
23602911-4	2013	We report herein that arsenite-generated ROS/RNS inhibits PARP-1 activity in cells.	arsenite	22-30	FAM20C golgi associated secretory pathway kinase	Homo sapiens	45-48
23602911-4	2013	We report herein that arsenite-generated ROS/RNS inhibits PARP-1 activity in cells.	arsenite	22-30	poly(ADP-ribose) polymerase 1	Homo sapiens	58-64
23602911-5	2013	Cellular exposure to arsenite, as well as hydrogen peroxide and NONOate (nitric oxide donor), decreased PARP-1 zinc content, enzymatic activity, and PARP-1 DNA binding.	arsenite	21-29	poly(ADP-ribose) polymerase 1	Homo sapiens	104-110
23602911-5	2013	Cellular exposure to arsenite, as well as hydrogen peroxide and NONOate (nitric oxide donor), decreased PARP-1 zinc content, enzymatic activity, and PARP-1 DNA binding.	arsenite	21-29	poly(ADP-ribose) polymerase 1	Homo sapiens	149-155
23602911-8	2013	These results strongly suggest that cellular generation of ROS/RNS plays an important role in arsenite inhibition of PARP-1 activity, leading to the loss of PARP-1 DNA-binding ability and enzymatic activity.	arsenite	94-102	poly(ADP-ribose) polymerase 1	Homo sapiens	117-123
23602911-8	2013	These results strongly suggest that cellular generation of ROS/RNS plays an important role in arsenite inhibition of PARP-1 activity, leading to the loss of PARP-1 DNA-binding ability and enzymatic activity.	arsenite	94-102	poly(ADP-ribose) polymerase 1	Homo sapiens	157-163
22354777-0	2013	Phosphorylation of histone H3 at serine 10 has an essential role in arsenite-induced expression of FOS, EGR1 and IL8 mRNA in cultured human cell lines.	arsenite	68-76	C-X-C motif chemokine ligand 8	Homo sapiens	113-116
23618899-0	2013	Expression of WWOX and FHIT is downregulated by exposure to arsenite in human uroepithelial cells.	arsenite	60-68	WW domain containing oxidoreductase	Homo sapiens	14-18
22354777-0	2013	Phosphorylation of histone H3 at serine 10 has an essential role in arsenite-induced expression of FOS, EGR1 and IL8 mRNA in cultured human cell lines.	arsenite	68-76	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	99-102
22354777-0	2013	Phosphorylation of histone H3 at serine 10 has an essential role in arsenite-induced expression of FOS, EGR1 and IL8 mRNA in cultured human cell lines.	arsenite	68-76	early growth response 1	Homo sapiens	104-108
23824327-4	2013	Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq).	arsenite	69-77	argonaute RISC catalytic component 2	Homo sapiens	41-45
23618899-7	2013	In fact, the results for the arsenite-treated groups showed that ATR, WWOX and FHIT are downregulated by arsenite in SV-HUC-1.	arsenite	29-37	fragile histidine triad diadenosine triphosphatase	Homo sapiens	79-83
23715767-6	2013	The expression of Egr-1, p21 and JNK was strongly increased after treatment of the cells with TPA, tumor necrosis factor-alpha (TNF-alpha) or arsenite.	arsenite	142-150	early growth response 1	Homo sapiens	18-23
23715767-6	2013	The expression of Egr-1, p21 and JNK was strongly increased after treatment of the cells with TPA, tumor necrosis factor-alpha (TNF-alpha) or arsenite.	arsenite	142-150	cyclin dependent kinase inhibitor 1A	Homo sapiens	25-28
23715767-6	2013	The expression of Egr-1, p21 and JNK was strongly increased after treatment of the cells with TPA, tumor necrosis factor-alpha (TNF-alpha) or arsenite.	arsenite	142-150	mitogen-activated protein kinase 8	Homo sapiens	33-36
23618899-0	2013	Expression of WWOX and FHIT is downregulated by exposure to arsenite in human uroepithelial cells.	arsenite	60-68	fragile histidine triad diadenosine triphosphatase	Homo sapiens	23-27
23618899-7	2013	In fact, the results for the arsenite-treated groups showed that ATR, WWOX and FHIT are downregulated by arsenite in SV-HUC-1.	arsenite	29-37	ATR serine/threonine kinase	Homo sapiens	65-68
23618899-7	2013	In fact, the results for the arsenite-treated groups showed that ATR, WWOX and FHIT are downregulated by arsenite in SV-HUC-1.	arsenite	29-37	WW domain containing oxidoreductase	Homo sapiens	70-74
23618899-7	2013	In fact, the results for the arsenite-treated groups showed that ATR, WWOX and FHIT are downregulated by arsenite in SV-HUC-1.	arsenite	105-113	ATR serine/threonine kinase	Homo sapiens	65-68
23618899-7	2013	In fact, the results for the arsenite-treated groups showed that ATR, WWOX and FHIT are downregulated by arsenite in SV-HUC-1.	arsenite	105-113	WW domain containing oxidoreductase	Homo sapiens	70-74
23618899-7	2013	In fact, the results for the arsenite-treated groups showed that ATR, WWOX and FHIT are downregulated by arsenite in SV-HUC-1.	arsenite	105-113	fragile histidine triad diadenosine triphosphatase	Homo sapiens	79-83
23618899-8	2013	However, the inhibitors suppressed the effects of arsenite on WWOX and FHIT proteins and mRNA expression.	arsenite	50-58	WW domain containing oxidoreductase	Homo sapiens	62-66
23618899-9	2013	In conclusion, arsenite decreased expressions of ATR, WWOX and FHIT via ERK1/2 activation in SV-HUC-1 cells.	arsenite	15-23	ATR serine/threonine kinase	Homo sapiens	49-52
23618899-9	2013	In conclusion, arsenite decreased expressions of ATR, WWOX and FHIT via ERK1/2 activation in SV-HUC-1 cells.	arsenite	15-23	WW domain containing oxidoreductase	Homo sapiens	54-58
23618899-9	2013	In conclusion, arsenite decreased expressions of ATR, WWOX and FHIT via ERK1/2 activation in SV-HUC-1 cells.	arsenite	15-23	fragile histidine triad diadenosine triphosphatase	Homo sapiens	63-67
23618899-9	2013	In conclusion, arsenite decreased expressions of ATR, WWOX and FHIT via ERK1/2 activation in SV-HUC-1 cells.	arsenite	15-23	mitogen-activated protein kinase 3	Homo sapiens	72-78
23463292-1	2013	Aquaporin-3 (AQP3), a water/glycerol-transporting protein that facilitates water, urea, and glycerol transport, can inhibit arsenite-induced apoptosis by up-regulating Bcl-2.	arsenite	124-132	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
23463292-1	2013	Aquaporin-3 (AQP3), a water/glycerol-transporting protein that facilitates water, urea, and glycerol transport, can inhibit arsenite-induced apoptosis by up-regulating Bcl-2.	arsenite	124-132	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
23463292-1	2013	Aquaporin-3 (AQP3), a water/glycerol-transporting protein that facilitates water, urea, and glycerol transport, can inhibit arsenite-induced apoptosis by up-regulating Bcl-2.	arsenite	124-132	BCL2 apoptosis regulator	Homo sapiens	168-173
24218851-8	2013	The function loss of orf8 resulted in a remarkable decrease in resistance to arsenate, though not arsenite.	arsenite	98-106	putative regulator	Escherichia coli	21-25
23069812-0	2013	EMT and CSC-like properties mediated by the IKKbeta/IkappaBalpha/RelA signal pathway via the transcriptional regulator, Snail, are involved in the arsenite-induced neoplastic transformation of human keratinocytes.	arsenite	147-155	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	44-51
23566955-0	2013	Arsenite suppression of BMP signaling in human keratinocytes.	arsenite	0-8	bone morphogenetic protein 1	Homo sapiens	24-27
23566955-2	2013	Exploring the mechanism of this suppression revealed that BMP-6 greatly increased levels of mRNA for keratins 1 and 10, two of the earliest differentiation markers expressed, a process prevented by co-treatment with arsenite.	arsenite	216-224	bone morphogenetic protein 6	Homo sapiens	58-63
23566955-3	2013	BMP also stimulated, and arsenite suppressed, mRNA for FOXN1, an important transcription factor driving early keratinocyte differentiation.	arsenite	25-33	forkhead box N1	Homo sapiens	55-60
23566955-6	2013	Supporting a requirement for Notch1 signaling in keratin induction, BMP increased levels of activated Notch1, which was blocked by arsenite.	arsenite	131-139	notch receptor 1	Homo sapiens	29-35
23566955-6	2013	Supporting a requirement for Notch1 signaling in keratin induction, BMP increased levels of activated Notch1, which was blocked by arsenite.	arsenite	131-139	bone morphogenetic protein 1	Homo sapiens	68-71
23566955-6	2013	Supporting a requirement for Notch1 signaling in keratin induction, BMP increased levels of activated Notch1, which was blocked by arsenite.	arsenite	131-139	notch receptor 1	Homo sapiens	102-108
23566955-7	2013	BMP also greatly decreased active ERK, while co-treatment with arsenite maintained active ERK.	arsenite	63-71	mitogen-activated protein kinase 1	Homo sapiens	90-93
23566955-8	2013	Inhibition of ERK signaling mimicked BMP by inducing keratin and FOXN1 mRNAs and by increasing active Notch1, effects blocked by arsenite.	arsenite	129-137	mitogen-activated protein kinase 1	Homo sapiens	14-17
23566955-8	2013	Inhibition of ERK signaling mimicked BMP by inducing keratin and FOXN1 mRNAs and by increasing active Notch1, effects blocked by arsenite.	arsenite	129-137	bone morphogenetic protein 1	Homo sapiens	37-40
23566955-8	2013	Inhibition of ERK signaling mimicked BMP by inducing keratin and FOXN1 mRNAs and by increasing active Notch1, effects blocked by arsenite.	arsenite	129-137	notch receptor 1	Homo sapiens	102-108
23566955-9	2013	Of 6 dual-specificity phosphatases (DUSPs) targeting ERK, two were induced by BMP unless prevented by simultaneous exposure to arsenite and EGF.	arsenite	127-135	mitogen-activated protein kinase 1	Homo sapiens	53-56
23566955-9	2013	Of 6 dual-specificity phosphatases (DUSPs) targeting ERK, two were induced by BMP unless prevented by simultaneous exposure to arsenite and EGF.	arsenite	127-135	bone morphogenetic protein 1	Homo sapiens	78-81
23566955-13	2013	Arsenite prevents this cascade by maintaining ERK signaling, at least in part by suppressing DUSP expression.	arsenite	0-8	mitogen-activated protein kinase 1	Homo sapiens	46-49
23566955-13	2013	Arsenite prevents this cascade by maintaining ERK signaling, at least in part by suppressing DUSP expression.	arsenite	0-8	dual specificity phosphatase 5	Homo sapiens	93-97
23069812-0	2013	EMT and CSC-like properties mediated by the IKKbeta/IkappaBalpha/RelA signal pathway via the transcriptional regulator, Snail, are involved in the arsenite-induced neoplastic transformation of human keratinocytes.	arsenite	147-155	NFKB inhibitor alpha	Homo sapiens	52-64
23069812-0	2013	EMT and CSC-like properties mediated by the IKKbeta/IkappaBalpha/RelA signal pathway via the transcriptional regulator, Snail, are involved in the arsenite-induced neoplastic transformation of human keratinocytes.	arsenite	147-155	RELA proto-oncogene, NF-kB subunit	Homo sapiens	65-69
23069812-0	2013	EMT and CSC-like properties mediated by the IKKbeta/IkappaBalpha/RelA signal pathway via the transcriptional regulator, Snail, are involved in the arsenite-induced neoplastic transformation of human keratinocytes.	arsenite	147-155	snail family transcriptional repressor 1	Homo sapiens	120-125
23069812-6	2013	Inhibition of NF-kappaB RelA blocked the arsenite-induced EMT, acquisition of a CSC-like phenotype, and neoplastic transformation.	arsenite	41-49	nuclear factor kappa B subunit 1	Homo sapiens	14-23
23069812-6	2013	Inhibition of NF-kappaB RelA blocked the arsenite-induced EMT, acquisition of a CSC-like phenotype, and neoplastic transformation.	arsenite	41-49	RELA proto-oncogene, NF-kB subunit	Homo sapiens	24-28
23069812-7	2013	These observations show that EMT, along with acquisition of a CSC-like phenotype mediated by IKKbeta/IkappaBalpha/RelA signal pathway via Snail, contributes to a low concentration of arsenite-induced tumorigenesis.	arsenite	183-191	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	93-100
23069812-7	2013	These observations show that EMT, along with acquisition of a CSC-like phenotype mediated by IKKbeta/IkappaBalpha/RelA signal pathway via Snail, contributes to a low concentration of arsenite-induced tumorigenesis.	arsenite	183-191	NFKB inhibitor alpha	Homo sapiens	101-113
23069812-7	2013	These observations show that EMT, along with acquisition of a CSC-like phenotype mediated by IKKbeta/IkappaBalpha/RelA signal pathway via Snail, contributes to a low concentration of arsenite-induced tumorigenesis.	arsenite	183-191	RELA proto-oncogene, NF-kB subunit	Homo sapiens	114-118
23069812-7	2013	These observations show that EMT, along with acquisition of a CSC-like phenotype mediated by IKKbeta/IkappaBalpha/RelA signal pathway via Snail, contributes to a low concentration of arsenite-induced tumorigenesis.	arsenite	183-191	snail family transcriptional repressor 1	Homo sapiens	138-143
23369756-0	2013	Differential modulation of cytochrome P450 1a1 by arsenite in vivo and in vitro in C57BL/6 mice.	arsenite	50-58	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	27-46
23563754-8	2013	These findings suggest that the AQP9 expression status of APL patients is a predictive marker for the successful outcome of ATO treatment, since AQP9 plays a pivotal role in various arsenite-mediated biological effects on normal and cancer cells.	arsenite	182-190	aquaporin 9	Homo sapiens	32-36
23563754-8	2013	These findings suggest that the AQP9 expression status of APL patients is a predictive marker for the successful outcome of ATO treatment, since AQP9 plays a pivotal role in various arsenite-mediated biological effects on normal and cancer cells.	arsenite	182-190	aquaporin 9	Homo sapiens	145-149
23681232-0	2013	GADD45beta mediates p53 protein degradation via Src/PP2A/MDM2 pathway upon arsenite treatment.	arsenite	75-83	growth arrest and DNA-damage-inducible 45 beta	Mus musculus	0-10
23681232-0	2013	GADD45beta mediates p53 protein degradation via Src/PP2A/MDM2 pathway upon arsenite treatment.	arsenite	75-83	transformation related protein 53, pseudogene	Mus musculus	20-23
23681232-0	2013	GADD45beta mediates p53 protein degradation via Src/PP2A/MDM2 pathway upon arsenite treatment.	arsenite	75-83	Rous sarcoma oncogene	Mus musculus	48-51
23681232-0	2013	GADD45beta mediates p53 protein degradation via Src/PP2A/MDM2 pathway upon arsenite treatment.	arsenite	75-83	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	52-56
23681232-0	2013	GADD45beta mediates p53 protein degradation via Src/PP2A/MDM2 pathway upon arsenite treatment.	arsenite	75-83	transformed mouse 3T3 cell double minute 2	Mus musculus	57-61
23681232-2	2013	We demonstrated here that GADD45beta mediated its anti-apoptotic effect via promoting p53 protein degradation following arsenite treatment.	arsenite	120-128	growth arrest and DNA-damage-inducible 45 beta	Mus musculus	26-36
23681232-2	2013	We demonstrated here that GADD45beta mediated its anti-apoptotic effect via promoting p53 protein degradation following arsenite treatment.	arsenite	120-128	transformation related protein 53, pseudogene	Mus musculus	86-89
23681232-3	2013	We found that p53 protein expression was upregulated in GADD45beta-/- cells upon arsenite exposure as compared with those in GADD45beta+/+ cells.	arsenite	81-89	transformation related protein 53, pseudogene	Mus musculus	14-17
23681232-3	2013	We found that p53 protein expression was upregulated in GADD45beta-/- cells upon arsenite exposure as compared with those in GADD45beta+/+ cells.	arsenite	81-89	growth arrest and DNA-damage-inducible 45 beta	Mus musculus	56-66
23681232-5	2013	Moreover, we identified that GADD45beta-mediated p53 protein degradation was crucial for its anti-apoptotic effect due to arsenite exposure, whereas increased JNK activation was not involved in the increased cell apoptotic response in GADD45beta-/- cells under same experimental conditions.	arsenite	122-130	growth arrest and DNA-damage-inducible 45 beta	Mus musculus	29-39
23681232-5	2013	Moreover, we identified that GADD45beta-mediated p53 protein degradation was crucial for its anti-apoptotic effect due to arsenite exposure, whereas increased JNK activation was not involved in the increased cell apoptotic response in GADD45beta-/- cells under same experimental conditions.	arsenite	122-130	transformation related protein 53, pseudogene	Mus musculus	49-52
23681232-6	2013	Collectively, our results demonstrate a novel molecular mechanism responsible for GADD45beta protection of arsenite-exposed cells from cell death, which provides insight into our understanding of GADD45beta function and a unique compound arsenite as both a cancer therapeutic reagent and an environmental carcinogen.	arsenite	107-115	growth arrest and DNA-damage-inducible 45 beta	Mus musculus	82-92
23681232-6	2013	Collectively, our results demonstrate a novel molecular mechanism responsible for GADD45beta protection of arsenite-exposed cells from cell death, which provides insight into our understanding of GADD45beta function and a unique compound arsenite as both a cancer therapeutic reagent and an environmental carcinogen.	arsenite	107-115	growth arrest and DNA-damage-inducible 45 beta	Mus musculus	196-206
23681232-6	2013	Collectively, our results demonstrate a novel molecular mechanism responsible for GADD45beta protection of arsenite-exposed cells from cell death, which provides insight into our understanding of GADD45beta function and a unique compound arsenite as both a cancer therapeutic reagent and an environmental carcinogen.	arsenite	238-246	growth arrest and DNA-damage-inducible 45 beta	Mus musculus	82-92
23369756-1	2013	Heavy metals, typified by arsenite (As(III)), have been implicated in altering the carcinogenicity of aryl hydrocarbon receptor (AhR) ligands, typified by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), by modulating the induction of the Cyp1a1 enzyme, but the mechanism remains unresolved.	arsenite	26-34	aryl-hydrocarbon receptor	Mus musculus	102-127
23369756-1	2013	Heavy metals, typified by arsenite (As(III)), have been implicated in altering the carcinogenicity of aryl hydrocarbon receptor (AhR) ligands, typified by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), by modulating the induction of the Cyp1a1 enzyme, but the mechanism remains unresolved.	arsenite	26-34	aryl-hydrocarbon receptor	Mus musculus	129-132
23369756-1	2013	Heavy metals, typified by arsenite (As(III)), have been implicated in altering the carcinogenicity of aryl hydrocarbon receptor (AhR) ligands, typified by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), by modulating the induction of the Cyp1a1 enzyme, but the mechanism remains unresolved.	arsenite	26-34	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	234-240
23563151-0	2013	Ribosomal protein S7 regulates arsenite-induced GADD45alpha expression by attenuating MDM2-mediated GADD45alpha ubiquitination and degradation.	arsenite	31-39	growth arrest and DNA damage inducible alpha	Homo sapiens	48-59
23563151-0	2013	Ribosomal protein S7 regulates arsenite-induced GADD45alpha expression by attenuating MDM2-mediated GADD45alpha ubiquitination and degradation.	arsenite	31-39	MDM2 proto-oncogene	Homo sapiens	86-90
23563151-0	2013	Ribosomal protein S7 regulates arsenite-induced GADD45alpha expression by attenuating MDM2-mediated GADD45alpha ubiquitination and degradation.	arsenite	31-39	growth arrest and DNA damage inducible alpha	Homo sapiens	100-111
23563151-2	2013	In our recent study, we demonstrate that GADD45alpha undergoes a dynamic ubiquitination and degradation in vivo, which process can be blocked by the cytotoxic reagent, arsenite, resulting in GADD45alpha accumulation to activate JNKs cell death pathway, thereby revealing a novel mechanism for the cellular GADD45alpha functional regulation.	arsenite	168-176	growth arrest and DNA damage inducible alpha	Homo sapiens	41-52
23563151-2	2013	In our recent study, we demonstrate that GADD45alpha undergoes a dynamic ubiquitination and degradation in vivo, which process can be blocked by the cytotoxic reagent, arsenite, resulting in GADD45alpha accumulation to activate JNKs cell death pathway, thereby revealing a novel mechanism for the cellular GADD45alpha functional regulation.	arsenite	168-176	growth arrest and DNA damage inducible alpha	Homo sapiens	191-202
23563151-2	2013	In our recent study, we demonstrate that GADD45alpha undergoes a dynamic ubiquitination and degradation in vivo, which process can be blocked by the cytotoxic reagent, arsenite, resulting in GADD45alpha accumulation to activate JNKs cell death pathway, thereby revealing a novel mechanism for the cellular GADD45alpha functional regulation.	arsenite	168-176	growth arrest and DNA damage inducible alpha	Homo sapiens	191-202
23563151-7	2013	Further investigations indicated that arsenite treatment enhanced S7-MDM2 interaction, resulting in attenuation of MDM2-dependent GADD45alpha ubiquitination and degradation, thereby leading to GADD45alpha-dependent cell death pathway activation.	arsenite	38-46	MDM2 proto-oncogene	Homo sapiens	69-73
23563151-7	2013	Further investigations indicated that arsenite treatment enhanced S7-MDM2 interaction, resulting in attenuation of MDM2-dependent GADD45alpha ubiquitination and degradation, thereby leading to GADD45alpha-dependent cell death pathway activation.	arsenite	38-46	MDM2 proto-oncogene	Homo sapiens	115-119
23563151-7	2013	Further investigations indicated that arsenite treatment enhanced S7-MDM2 interaction, resulting in attenuation of MDM2-dependent GADD45alpha ubiquitination and degradation, thereby leading to GADD45alpha-dependent cell death pathway activation.	arsenite	38-46	growth arrest and DNA damage inducible alpha	Homo sapiens	130-141
23563151-7	2013	Further investigations indicated that arsenite treatment enhanced S7-MDM2 interaction, resulting in attenuation of MDM2-dependent GADD45alpha ubiquitination and degradation, thereby leading to GADD45alpha-dependent cell death pathway activation.	arsenite	38-46	growth arrest and DNA damage inducible alpha	Homo sapiens	193-204
23563151-8	2013	Silencing S7 expression suppressed GADD45alpha-dependent cytotoxicity induced by arsenite.	arsenite	81-89	growth arrest and DNA damage inducible alpha	Homo sapiens	35-46
23341463-10	2013	Endogenous WDR62 and MAPKBP1 co-localize to stress granules following arsenite treatment, but not during mitosis.	arsenite	70-78	WD repeat domain 62	Homo sapiens	11-16
23523789-0	2013	The metalloid arsenite induces nuclear export of Id3 possibly via binding to the N-terminal cysteine residues.	arsenite	14-22	inhibitor of DNA binding 3, HLH protein	Homo sapiens	49-52
23523789-3	2013	In this study, we found that treatment with the stress-inducing metalloid arsenite led to the accumulation of GFP-tagged Id3 in the cytoplasm.	arsenite	74-82	inhibitor of DNA binding 3, HLH protein	Homo sapiens	121-124
23333640-0	2013	The inhibition of HIF-2alpha on the ATM/Chk-2 pathway is involved in the promotion effect of arsenite on benzo(a)pyrene-induced cell transformation.	arsenite	93-101	endothelial PAS domain protein 1	Homo sapiens	18-28
23333640-0	2013	The inhibition of HIF-2alpha on the ATM/Chk-2 pathway is involved in the promotion effect of arsenite on benzo(a)pyrene-induced cell transformation.	arsenite	93-101	ATM serine/threonine kinase	Homo sapiens	36-39
23333640-0	2013	The inhibition of HIF-2alpha on the ATM/Chk-2 pathway is involved in the promotion effect of arsenite on benzo(a)pyrene-induced cell transformation.	arsenite	93-101	checkpoint kinase 2	Homo sapiens	40-45
23376440-10	2013	These data indicate that arsenite promotes an induction of ROS, which results in an induction of COX-2 expression through activation of the MAPK pathway.	arsenite	25-33	prostaglandin-endoperoxide synthase 2	Homo sapiens	97-102
23523789-6	2013	Importantly, we showed that the closely spaced N-terminal cysteine residues of Id3 interacted with the arsenic derivative phenylarsine oxide (PAO) and were essential for the arsenite-induced cytoplasmic accumulation, suggesting that arsenite induces the CRM1-dependent nuclear export of Id3 via binding to the N-terminal cysteines.	arsenite	174-182	inhibitor of DNA binding 3, HLH protein	Homo sapiens	79-82
23523789-6	2013	Importantly, we showed that the closely spaced N-terminal cysteine residues of Id3 interacted with the arsenic derivative phenylarsine oxide (PAO) and were essential for the arsenite-induced cytoplasmic accumulation, suggesting that arsenite induces the CRM1-dependent nuclear export of Id3 via binding to the N-terminal cysteines.	arsenite	174-182	exportin 1	Homo sapiens	254-258
23523789-6	2013	Importantly, we showed that the closely spaced N-terminal cysteine residues of Id3 interacted with the arsenic derivative phenylarsine oxide (PAO) and were essential for the arsenite-induced cytoplasmic accumulation, suggesting that arsenite induces the CRM1-dependent nuclear export of Id3 via binding to the N-terminal cysteines.	arsenite	174-182	inhibitor of DNA binding 3, HLH protein	Homo sapiens	287-290
23523789-6	2013	Importantly, we showed that the closely spaced N-terminal cysteine residues of Id3 interacted with the arsenic derivative phenylarsine oxide (PAO) and were essential for the arsenite-induced cytoplasmic accumulation, suggesting that arsenite induces the CRM1-dependent nuclear export of Id3 via binding to the N-terminal cysteines.	arsenite	233-241	inhibitor of DNA binding 3, HLH protein	Homo sapiens	79-82
23523789-6	2013	Importantly, we showed that the closely spaced N-terminal cysteine residues of Id3 interacted with the arsenic derivative phenylarsine oxide (PAO) and were essential for the arsenite-induced cytoplasmic accumulation, suggesting that arsenite induces the CRM1-dependent nuclear export of Id3 via binding to the N-terminal cysteines.	arsenite	233-241	exportin 1	Homo sapiens	254-258
23523789-6	2013	Importantly, we showed that the closely spaced N-terminal cysteine residues of Id3 interacted with the arsenic derivative phenylarsine oxide (PAO) and were essential for the arsenite-induced cytoplasmic accumulation, suggesting that arsenite induces the CRM1-dependent nuclear export of Id3 via binding to the N-terminal cysteines.	arsenite	233-241	inhibitor of DNA binding 3, HLH protein	Homo sapiens	287-290
23523789-7	2013	Finally, we demonstrated that Id3 significantly repressed arsenite-stimulated transcription of the immediate-early gene Egr-1 and that this repression activity was inversely correlated with the arsenite-induced nuclear export.	arsenite	58-66	inhibitor of DNA binding 3, HLH protein	Homo sapiens	30-33
23523789-7	2013	Finally, we demonstrated that Id3 significantly repressed arsenite-stimulated transcription of the immediate-early gene Egr-1 and that this repression activity was inversely correlated with the arsenite-induced nuclear export.	arsenite	58-66	early growth response 1	Homo sapiens	120-125
23523789-7	2013	Finally, we demonstrated that Id3 significantly repressed arsenite-stimulated transcription of the immediate-early gene Egr-1 and that this repression activity was inversely correlated with the arsenite-induced nuclear export.	arsenite	194-202	inhibitor of DNA binding 3, HLH protein	Homo sapiens	30-33
23523789-8	2013	Our results imply that Id3 may be involved in the biological action of arsenite.	arsenite	71-79	inhibitor of DNA binding 3, HLH protein	Homo sapiens	23-26
23333640-1	2013	Both arsenite and benzo(a)pyrene (BaP) are known human carcinogens.	arsenite	5-13	prohibitin 2	Homo sapiens	34-37
23123503-10	2013	Indeed, both nutrient (amino acid deprivation) and oxidative stress (arsenite) were found to induce Fgf21 expression in hepatoma cells and isolated rat hepatocytes.	arsenite	69-77	fibroblast growth factor 21	Rattus norvegicus	100-105
23219847-7	2013	Beside caspase-9 and caspase-3 inhibitors, suppression of JNK activity decreased levels of arsenite-induced apoptosis in NSC.	arsenite	91-99	mitogen-activated protein kinase 8	Homo sapiens	58-61
23376440-6	2013	Our results demonstrate that arsenite (1-10 muM) elevates COX-2 expression, GSH levels, ROS and Nrf2 expression.	arsenite	29-37	prostaglandin-endoperoxide synthase 2	Homo sapiens	58-63
23376440-6	2013	Our results demonstrate that arsenite (1-10 muM) elevates COX-2 expression, GSH levels, ROS and Nrf2 expression.	arsenite	29-37	NFE2 like bZIP transcription factor 2	Homo sapiens	96-100
23376440-7	2013	Arsenite treatment for 24h stimulates phosphorylation of ERK and p38, but not JNK in SV-HUC-1 cells.	arsenite	0-8	mitogen-activated protein kinase 14	Homo sapiens	65-68
23376440-8	2013	Induction of Cox-2 mRNA levels by arsenite was attenuated by inhibitors of ERK, p38 and JNK.	arsenite	34-42	prostaglandin-endoperoxide synthase 2	Homo sapiens	13-18
23376440-8	2013	Induction of Cox-2 mRNA levels by arsenite was attenuated by inhibitors of ERK, p38 and JNK.	arsenite	34-42	mitogen-activated protein kinase 14	Homo sapiens	80-83
23376440-8	2013	Induction of Cox-2 mRNA levels by arsenite was attenuated by inhibitors of ERK, p38 and JNK.	arsenite	34-42	mitogen-activated protein kinase 8	Homo sapiens	88-91
23376440-9	2013	Arsenite-induced ROS generation and COX-2 expression were significantly attenuated by treatment with melatonin (a ROS scavenger), but enhanced by DL-buthionine-(S, R)-sulfoximine (BSO, an inhibitor of gamma-glutamylcysteine synthetase (gamma-GCS) resulting in lower GSH and increased ROS levels).	arsenite	0-8	glutamate-cysteine ligase catalytic subunit	Homo sapiens	201-234
23376440-9	2013	Arsenite-induced ROS generation and COX-2 expression were significantly attenuated by treatment with melatonin (a ROS scavenger), but enhanced by DL-buthionine-(S, R)-sulfoximine (BSO, an inhibitor of gamma-glutamylcysteine synthetase (gamma-GCS) resulting in lower GSH and increased ROS levels).	arsenite	0-8	glutamate-cysteine ligase catalytic subunit	Homo sapiens	236-245
23341463-10	2013	Endogenous WDR62 and MAPKBP1 co-localize to stress granules following arsenite treatment, but not during mitosis.	arsenite	70-78	mitogen-activated protein kinase binding protein 1	Homo sapiens	21-28
23279204-6	2013	Although single knockdown of either G3BP1 or G3BP2 in 293T cells partially reduced the number of SG-positive cells induced by arsenite, the knockdowns of both genes significantly reduced the number.	arsenite	126-134	G3BP stress granule assembly factor 1	Homo sapiens	36-41
23238642-7	2013	Arsenate reductase activity was found to be conferred by arsC gene, which in many strains was coupled with arsenite efflux gene arsB as well.	arsenite	107-115	steroid sulfatase	Homo sapiens	57-61
23238642-7	2013	Arsenate reductase activity was found to be conferred by arsC gene, which in many strains was coupled with arsenite efflux gene arsB as well.	arsenite	107-115	arylsulfatase B	Homo sapiens	128-132
23283970-10	2013	Similarly, in dopaminergic MN9D cells, arsenite induced the export of endogenous Nurr1, resulting in the loss of expression of Nurr1-dependent genes.	arsenite	39-47	nuclear receptor subfamily 4, group A, member 2	Mus musculus	81-86
23283970-10	2013	Similarly, in dopaminergic MN9D cells, arsenite induced the export of endogenous Nurr1, resulting in the loss of expression of Nurr1-dependent genes.	arsenite	39-47	nuclear receptor subfamily 4, group A, member 2	Mus musculus	127-132
24024143-0	2013	Arsenite-induced stress signaling: modulation of the phosphoinositide 3"-kinase/Akt/FoxO signaling cascade.	arsenite	0-8	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	53-79
24024143-0	2013	Arsenite-induced stress signaling: modulation of the phosphoinositide 3"-kinase/Akt/FoxO signaling cascade.	arsenite	0-8	AKT serine/threonine kinase 1	Homo sapiens	80-83
24024143-5	2013	In contrast, a strong phosphorylation of FoxO1a/FoxO3a and Akt was observed at subcytotoxic concentrations of arsenite in HaCaT human keratinocytes.	arsenite	110-118	forkhead box O1	Homo sapiens	41-47
24024143-5	2013	In contrast, a strong phosphorylation of FoxO1a/FoxO3a and Akt was observed at subcytotoxic concentrations of arsenite in HaCaT human keratinocytes.	arsenite	110-118	forkhead box O3	Homo sapiens	48-54
24024143-5	2013	In contrast, a strong phosphorylation of FoxO1a/FoxO3a and Akt was observed at subcytotoxic concentrations of arsenite in HaCaT human keratinocytes.	arsenite	110-118	AKT serine/threonine kinase 1	Homo sapiens	59-62
23229538-7	2013	PEDF protein level was only changed when the arsenite dose reached 50 mg/L in liver and brain, whereas it was not changed in the kidney.	arsenite	45-53	serpin family F member 1	Rattus norvegicus	0-4
23229538-8	2013	In order to investigate the possible mechanism of PEDF-exerted damages upon arsenite exposure, apoptosis in liver and brain was assessed.	arsenite	76-84	serpin family F member 1	Rattus norvegicus	50-54
23159405-0	2013	Differential regulation of M3/6 (DUSP8) signaling complexes in response to arsenite-induced oxidative stress.	arsenite	75-83	dual specificity phosphatase 8	Homo sapiens	33-38
23159405-9	2013	After activation of the pathway by exposure of cells to arsenite, the interaction of M3/6 with JNK1alpha and JNK3 was enhanced, whereas that with JNK1beta or JNK2alpha decreased.	arsenite	56-64	mitogen-activated protein kinase 10	Homo sapiens	109-113
23159405-9	2013	After activation of the pathway by exposure of cells to arsenite, the interaction of M3/6 with JNK1alpha and JNK3 was enhanced, whereas that with JNK1beta or JNK2alpha decreased.	arsenite	56-64	mitogen-activated protein kinase 9	Homo sapiens	158-167
23159405-11	2013	Furthermore, arsenite treatment resulted in an inducible recruitment of M3/6 to JNK-interacting protein 3 (JIP3) scaffold complexes, while its interaction with JIP1 or JIP2 was constitutive.	arsenite	13-21	mitogen-activated protein kinase 8 interacting protein 3	Homo sapiens	80-105
23159405-11	2013	Furthermore, arsenite treatment resulted in an inducible recruitment of M3/6 to JNK-interacting protein 3 (JIP3) scaffold complexes, while its interaction with JIP1 or JIP2 was constitutive.	arsenite	13-21	mitogen-activated protein kinase 8 interacting protein 3	Homo sapiens	107-111
23159405-11	2013	Furthermore, arsenite treatment resulted in an inducible recruitment of M3/6 to JNK-interacting protein 3 (JIP3) scaffold complexes, while its interaction with JIP1 or JIP2 was constitutive.	arsenite	13-21	mitogen-activated protein kinase 8 interacting protein 1	Homo sapiens	160-164
23159405-11	2013	Furthermore, arsenite treatment resulted in an inducible recruitment of M3/6 to JNK-interacting protein 3 (JIP3) scaffold complexes, while its interaction with JIP1 or JIP2 was constitutive.	arsenite	13-21	mitogen-activated protein kinase 8 interacting protein 2	Homo sapiens	168-172
23279204-6	2013	Although single knockdown of either G3BP1 or G3BP2 in 293T cells partially reduced the number of SG-positive cells induced by arsenite, the knockdowns of both genes significantly reduced the number.	arsenite	126-134	G3BP stress granule assembly factor 2	Homo sapiens	45-50
23152511-7	2013	The sequestration of p38-P and OGT in IBs appeared to be reversible: oxidative stress resulting from arsenite treatment transformed large IBs into a scattering of smaller bodies, suggestive of partial disassembly, and this was associated with MK2 phosphorylation and OGN addition.	arsenite	101-109	mitogen-activated protein kinase 14	Homo sapiens	21-24
23152511-7	2013	The sequestration of p38-P and OGT in IBs appeared to be reversible: oxidative stress resulting from arsenite treatment transformed large IBs into a scattering of smaller bodies, suggestive of partial disassembly, and this was associated with MK2 phosphorylation and OGN addition.	arsenite	101-109	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	31-34
23152511-7	2013	The sequestration of p38-P and OGT in IBs appeared to be reversible: oxidative stress resulting from arsenite treatment transformed large IBs into a scattering of smaller bodies, suggestive of partial disassembly, and this was associated with MK2 phosphorylation and OGN addition.	arsenite	101-109	MAPK activated protein kinase 2	Homo sapiens	243-246
23303087-3	2013	Arsenite (As(III)) which was not retained on the column was oxidized to As(V).	arsenite	0-8	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	72-77
23230274-9	2013	However, following exposure to arsenite, G3BP1 and USP10 induce the formation of SGs, which uncovers the antioxidant activity of USP10.	arsenite	31-39	ubiquitin specific peptidase 10	Homo sapiens	129-134
23137061-10	2013	During arsenite exposure, expression of several genes associated with normal kidney development and SC regulation and differentiation (i.e., Wt-1, Wnt-4, Bmp-7, etc.)	arsenite	7-15	Wnt family member 4	Homo sapiens	147-152
23137061-10	2013	During arsenite exposure, expression of several genes associated with normal kidney development and SC regulation and differentiation (i.e., Wt-1, Wnt-4, Bmp-7, etc.)	arsenite	7-15	bone morphogenetic protein 7	Homo sapiens	154-159
23194660-0	2013	The accumulations of HIF-1alpha and HIF-2alpha by JNK and ERK are involved in biphasic effects induced by different levels of arsenite in human bronchial epithelial cells.	arsenite	126-134	mitogen-activated protein kinase 8	Homo sapiens	50-53
23194660-0	2013	The accumulations of HIF-1alpha and HIF-2alpha by JNK and ERK are involved in biphasic effects induced by different levels of arsenite in human bronchial epithelial cells.	arsenite	126-134	mitogen-activated protein kinase 1	Homo sapiens	58-61
23194660-4	2013	Our results show that a low level of arsenite activates extracellular signal-regulated kinases (ERK), which probably mediate arsenite-inhibited degradation of ubiquitinated hypoxia-inducible factor-2alpha (HIF-2alpha) in HBE cells.	arsenite	37-45	mitogen-activated protein kinase 1	Homo sapiens	56-94
23194660-4	2013	Our results show that a low level of arsenite activates extracellular signal-regulated kinases (ERK), which probably mediate arsenite-inhibited degradation of ubiquitinated hypoxia-inducible factor-2alpha (HIF-2alpha) in HBE cells.	arsenite	37-45	mitogen-activated protein kinase 1	Homo sapiens	96-99
23194660-4	2013	Our results show that a low level of arsenite activates extracellular signal-regulated kinases (ERK), which probably mediate arsenite-inhibited degradation of ubiquitinated hypoxia-inducible factor-2alpha (HIF-2alpha) in HBE cells.	arsenite	37-45	endothelial PAS domain protein 1	Homo sapiens	173-204
23194660-4	2013	Our results show that a low level of arsenite activates extracellular signal-regulated kinases (ERK), which probably mediate arsenite-inhibited degradation of ubiquitinated hypoxia-inducible factor-2alpha (HIF-2alpha) in HBE cells.	arsenite	37-45	endothelial PAS domain protein 1	Homo sapiens	206-216
23194660-4	2013	Our results show that a low level of arsenite activates extracellular signal-regulated kinases (ERK), which probably mediate arsenite-inhibited degradation of ubiquitinated hypoxia-inducible factor-2alpha (HIF-2alpha) in HBE cells.	arsenite	125-133	mitogen-activated protein kinase 1	Homo sapiens	56-94
23194660-4	2013	Our results show that a low level of arsenite activates extracellular signal-regulated kinases (ERK), which probably mediate arsenite-inhibited degradation of ubiquitinated hypoxia-inducible factor-2alpha (HIF-2alpha) in HBE cells.	arsenite	125-133	mitogen-activated protein kinase 1	Homo sapiens	96-99
23194660-4	2013	Our results show that a low level of arsenite activates extracellular signal-regulated kinases (ERK), which probably mediate arsenite-inhibited degradation of ubiquitinated hypoxia-inducible factor-2alpha (HIF-2alpha) in HBE cells.	arsenite	125-133	endothelial PAS domain protein 1	Homo sapiens	173-204
23194660-4	2013	Our results show that a low level of arsenite activates extracellular signal-regulated kinases (ERK), which probably mediate arsenite-inhibited degradation of ubiquitinated hypoxia-inducible factor-2alpha (HIF-2alpha) in HBE cells.	arsenite	125-133	endothelial PAS domain protein 1	Homo sapiens	206-216
23194660-5	2013	ERK inhibition blocks cell proliferation induced by a low level of arsenite, in part via HIF-2alpha.	arsenite	67-75	mitogen-activated protein kinase 1	Homo sapiens	0-3
23194660-5	2013	ERK inhibition blocks cell proliferation induced by a low level of arsenite, in part via HIF-2alpha.	arsenite	67-75	endothelial PAS domain protein 1	Homo sapiens	89-99
23194660-6	2013	In contrast, a high level of arsenite activates c-Jun N-terminal kinases (JNK), which provoke a response to suppress ubiquitinated HIF-1alpha degradation.	arsenite	29-37	mitogen-activated protein kinase 8	Homo sapiens	48-72
23194660-6	2013	In contrast, a high level of arsenite activates c-Jun N-terminal kinases (JNK), which provoke a response to suppress ubiquitinated HIF-1alpha degradation.	arsenite	29-37	mitogen-activated protein kinase 8	Homo sapiens	74-77
23194660-6	2013	In contrast, a high level of arsenite activates c-Jun N-terminal kinases (JNK), which provoke a response to suppress ubiquitinated HIF-1alpha degradation.	arsenite	29-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-141
23194660-7	2013	Down-regulation of HIF-1alpha by inhibiting JNK, however, increases the DNA damage but decreases the apoptosis induced by a high level of arsenite.	arsenite	138-146	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-29
23194660-7	2013	Down-regulation of HIF-1alpha by inhibiting JNK, however, increases the DNA damage but decreases the apoptosis induced by a high level of arsenite.	arsenite	138-146	mitogen-activated protein kinase 8	Homo sapiens	44-47
23194660-8	2013	Thus, data in the present study suggest that the accumulations of HIF-1alpha and HIF-2alpha by JNK and ERK are involved in different levels of arsenite-induced biphasic effects, with low levels of arsenite inducing cell proliferation and high levels of arsenite inducing DNA damage and apoptosis in HBE cells.	arsenite	143-151	mitogen-activated protein kinase 8	Homo sapiens	95-98
23194660-8	2013	Thus, data in the present study suggest that the accumulations of HIF-1alpha and HIF-2alpha by JNK and ERK are involved in different levels of arsenite-induced biphasic effects, with low levels of arsenite inducing cell proliferation and high levels of arsenite inducing DNA damage and apoptosis in HBE cells.	arsenite	143-151	mitogen-activated protein kinase 1	Homo sapiens	103-106
23194660-8	2013	Thus, data in the present study suggest that the accumulations of HIF-1alpha and HIF-2alpha by JNK and ERK are involved in different levels of arsenite-induced biphasic effects, with low levels of arsenite inducing cell proliferation and high levels of arsenite inducing DNA damage and apoptosis in HBE cells.	arsenite	197-205	mitogen-activated protein kinase 8	Homo sapiens	95-98
23194660-8	2013	Thus, data in the present study suggest that the accumulations of HIF-1alpha and HIF-2alpha by JNK and ERK are involved in different levels of arsenite-induced biphasic effects, with low levels of arsenite inducing cell proliferation and high levels of arsenite inducing DNA damage and apoptosis in HBE cells.	arsenite	197-205	mitogen-activated protein kinase 8	Homo sapiens	95-98
22967758-5	2012	RESULTS: Results showed that increase in nitric oxide synthase (NOS) activity, inflammatory markers expression, platelet aggregation, lipid peroxidation, protein oxidation, DNA damage and altered expression of liver X receptor-alpha (LXR-alpha) after arsenite treatment were restored with the supplementation of oils containing CLnA isomers.	arsenite	251-259	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	210-232
23469214-8	2013	Moreover, in arsenite-transformed HELF cells, inhibition of miR-21 promoted cell apoptosis, inhibited clonogenicity, and reduced migration.	arsenite	13-21	microRNA 21	Homo sapiens	60-66
23469214-9	2013	CONCLUSION: The results indicate that miR-21 is both a target and a regulator of ERK/NF-kappaB and JNK/c-Jun and the feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1, respectively, are involved in arsenite-induced malignant transformation of HELF cells.	arsenite	209-217	microRNA 21	Homo sapiens	38-44
23469214-9	2013	CONCLUSION: The results indicate that miR-21 is both a target and a regulator of ERK/NF-kappaB and JNK/c-Jun and the feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1, respectively, are involved in arsenite-induced malignant transformation of HELF cells.	arsenite	209-217	mitogen-activated protein kinase 1	Homo sapiens	81-84
23469214-9	2013	CONCLUSION: The results indicate that miR-21 is both a target and a regulator of ERK/NF-kappaB and JNK/c-Jun and the feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1, respectively, are involved in arsenite-induced malignant transformation of HELF cells.	arsenite	209-217	nuclear factor kappa B subunit 1	Homo sapiens	85-94
23469214-9	2013	CONCLUSION: The results indicate that miR-21 is both a target and a regulator of ERK/NF-kappaB and JNK/c-Jun and the feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1, respectively, are involved in arsenite-induced malignant transformation of HELF cells.	arsenite	209-217	mitogen-activated protein kinase 8	Homo sapiens	99-102
23469214-9	2013	CONCLUSION: The results indicate that miR-21 is both a target and a regulator of ERK/NF-kappaB and JNK/c-Jun and the feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1, respectively, are involved in arsenite-induced malignant transformation of HELF cells.	arsenite	209-217	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	103-108
23469214-9	2013	CONCLUSION: The results indicate that miR-21 is both a target and a regulator of ERK/NF-kappaB and JNK/c-Jun and the feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1, respectively, are involved in arsenite-induced malignant transformation of HELF cells.	arsenite	209-217	microRNA 21	Homo sapiens	141-147
23469214-9	2013	CONCLUSION: The results indicate that miR-21 is both a target and a regulator of ERK/NF-kappaB and JNK/c-Jun and the feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1, respectively, are involved in arsenite-induced malignant transformation of HELF cells.	arsenite	209-217	programmed cell death 4	Homo sapiens	162-167
23469214-9	2013	CONCLUSION: The results indicate that miR-21 is both a target and a regulator of ERK/NF-kappaB and JNK/c-Jun and the feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1, respectively, are involved in arsenite-induced malignant transformation of HELF cells.	arsenite	209-217	sprouty RTK signaling antagonist 1	Homo sapiens	172-177
23165982-0	2013	Involvement of Nrf2 activation in the upregulation of S100A9 by exposure             to inorganic arsenite.	arsenite	98-106	NFE2 like bZIP transcription factor 2	Homo sapiens	15-19
23165982-0	2013	Involvement of Nrf2 activation in the upregulation of S100A9 by exposure             to inorganic arsenite.	arsenite	98-106	S100 calcium binding protein A9	Homo sapiens	54-60
23469214-0	2013	Feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1 are involved in arsenite-induced cell malignant transformation.	arsenite	77-85	microRNA 21	Homo sapiens	24-30
23469214-0	2013	Feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1 are involved in arsenite-induced cell malignant transformation.	arsenite	77-85	programmed cell death 4	Homo sapiens	45-50
23469214-0	2013	Feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1 are involved in arsenite-induced cell malignant transformation.	arsenite	77-85	sprouty RTK signaling antagonist 1	Homo sapiens	55-60
23469214-4	2013	RESULTS: MiR-21 was highly expressed in arsenite-transformed HELF cells and normal HELF cells acutely treated with arsenite, an effect that was concomitant with activation of JNK/c-Jun and ERK/NF-kappaB and down-regulation of Pdcd4 and Spry1 protein levels.	arsenite	40-48	microRNA 21	Homo sapiens	9-15
23469214-4	2013	RESULTS: MiR-21 was highly expressed in arsenite-transformed HELF cells and normal HELF cells acutely treated with arsenite, an effect that was concomitant with activation of JNK/c-Jun and ERK/NF-kappaB and down-regulation of Pdcd4 and Spry1 protein levels.	arsenite	40-48	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	179-184
23469214-4	2013	RESULTS: MiR-21 was highly expressed in arsenite-transformed HELF cells and normal HELF cells acutely treated with arsenite, an effect that was concomitant with activation of JNK/c-Jun and ERK/NF-kappaB and down-regulation of Pdcd4 and Spry1 protein levels.	arsenite	115-123	microRNA 21	Homo sapiens	9-15
23469214-7	2013	Down-regulation of miR-21 and up-regulations of Pdcd44 or Spry1 blocked the arsenite-induced activations of JNK/c-Jun or ERK/NF-kappaB, indicating that knockdown of miR-21 inhibits feedback of ERK activation and JNK activation via increases of Pdcd4 and Spry1 protein levels, respectively.	arsenite	76-84	microRNA 21	Homo sapiens	19-25
23469214-7	2013	Down-regulation of miR-21 and up-regulations of Pdcd44 or Spry1 blocked the arsenite-induced activations of JNK/c-Jun or ERK/NF-kappaB, indicating that knockdown of miR-21 inhibits feedback of ERK activation and JNK activation via increases of Pdcd4 and Spry1 protein levels, respectively.	arsenite	76-84	sprouty RTK signaling antagonist 1	Homo sapiens	58-63
23469214-7	2013	Down-regulation of miR-21 and up-regulations of Pdcd44 or Spry1 blocked the arsenite-induced activations of JNK/c-Jun or ERK/NF-kappaB, indicating that knockdown of miR-21 inhibits feedback of ERK activation and JNK activation via increases of Pdcd4 and Spry1 protein levels, respectively.	arsenite	76-84	mitogen-activated protein kinase 8	Homo sapiens	108-111
23469214-7	2013	Down-regulation of miR-21 and up-regulations of Pdcd44 or Spry1 blocked the arsenite-induced activations of JNK/c-Jun or ERK/NF-kappaB, indicating that knockdown of miR-21 inhibits feedback of ERK activation and JNK activation via increases of Pdcd4 and Spry1 protein levels, respectively.	arsenite	76-84	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	112-117
23469214-7	2013	Down-regulation of miR-21 and up-regulations of Pdcd44 or Spry1 blocked the arsenite-induced activations of JNK/c-Jun or ERK/NF-kappaB, indicating that knockdown of miR-21 inhibits feedback of ERK activation and JNK activation via increases of Pdcd4 and Spry1 protein levels, respectively.	arsenite	76-84	mitogen-activated protein kinase 1	Homo sapiens	121-124
23469214-7	2013	Down-regulation of miR-21 and up-regulations of Pdcd44 or Spry1 blocked the arsenite-induced activations of JNK/c-Jun or ERK/NF-kappaB, indicating that knockdown of miR-21 inhibits feedback of ERK activation and JNK activation via increases of Pdcd4 and Spry1 protein levels, respectively.	arsenite	76-84	nuclear factor kappa B subunit 1	Homo sapiens	125-134
23469214-7	2013	Down-regulation of miR-21 and up-regulations of Pdcd44 or Spry1 blocked the arsenite-induced activations of JNK/c-Jun or ERK/NF-kappaB, indicating that knockdown of miR-21 inhibits feedback of ERK activation and JNK activation via increases of Pdcd4 and Spry1 protein levels, respectively.	arsenite	76-84	microRNA 21	Homo sapiens	165-171
23469214-7	2013	Down-regulation of miR-21 and up-regulations of Pdcd44 or Spry1 blocked the arsenite-induced activations of JNK/c-Jun or ERK/NF-kappaB, indicating that knockdown of miR-21 inhibits feedback of ERK activation and JNK activation via increases of Pdcd4 and Spry1 protein levels, respectively.	arsenite	76-84	mitogen-activated protein kinase 1	Homo sapiens	193-196
23469214-7	2013	Down-regulation of miR-21 and up-regulations of Pdcd44 or Spry1 blocked the arsenite-induced activations of JNK/c-Jun or ERK/NF-kappaB, indicating that knockdown of miR-21 inhibits feedback of ERK activation and JNK activation via increases of Pdcd4 and Spry1 protein levels, respectively.	arsenite	76-84	mitogen-activated protein kinase 8	Homo sapiens	212-215
23469214-7	2013	Down-regulation of miR-21 and up-regulations of Pdcd44 or Spry1 blocked the arsenite-induced activations of JNK/c-Jun or ERK/NF-kappaB, indicating that knockdown of miR-21 inhibits feedback of ERK activation and JNK activation via increases of Pdcd4 and Spry1 protein levels, respectively.	arsenite	76-84	programmed cell death 4	Homo sapiens	48-53
23469214-7	2013	Down-regulation of miR-21 and up-regulations of Pdcd44 or Spry1 blocked the arsenite-induced activations of JNK/c-Jun or ERK/NF-kappaB, indicating that knockdown of miR-21 inhibits feedback of ERK activation and JNK activation via increases of Pdcd4 and Spry1 protein levels, respectively.	arsenite	76-84	sprouty RTK signaling antagonist 1	Homo sapiens	254-259
22967758-5	2012	RESULTS: Results showed that increase in nitric oxide synthase (NOS) activity, inflammatory markers expression, platelet aggregation, lipid peroxidation, protein oxidation, DNA damage and altered expression of liver X receptor-alpha (LXR-alpha) after arsenite treatment were restored with the supplementation of oils containing CLnA isomers.	arsenite	251-259	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	234-243
23075303-3	2012	Here we tested the molecular-scale interaction of bisulfide (S(-II)) with NOM and its consequences for arsenite (As(III)) binding.	arsenite	103-111	transcription elongation factor A1	Homo sapiens	61-66
22706169-0	2012	Opposed arsenite-mediated regulation of p53-survivin is involved in neoplastic transformation, DNA damage, or apoptosis in human keratinocytes.	arsenite	8-16	tumor protein p53	Homo sapiens	40-43
22955273-0	2012	Rapid equilibrium kinetic analysis of arsenite methylation catalyzed by recombinant human arsenic (+3 oxidation state) methyltransferase (hAS3MT).	arsenite	38-46	arsenite methyltransferase	Homo sapiens	90-136
22955273-0	2012	Rapid equilibrium kinetic analysis of arsenite methylation catalyzed by recombinant human arsenic (+3 oxidation state) methyltransferase (hAS3MT).	arsenite	38-46	arsenite methyltransferase	Homo sapiens	138-144
22872678-4	2012	Enhanced mutant fibulin-3 secretion can also be achieved by activation of a PERK-independent eIF2alpha kinase through arsenite treatment and is independent of activating transcription factor 4 signaling and protein translation.	arsenite	118-126	EGF containing fibulin extracellular matrix protein 1	Homo sapiens	16-25
22872678-4	2012	Enhanced mutant fibulin-3 secretion can also be achieved by activation of a PERK-independent eIF2alpha kinase through arsenite treatment and is independent of activating transcription factor 4 signaling and protein translation.	arsenite	118-126	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	76-80
22872678-4	2012	Enhanced mutant fibulin-3 secretion can also be achieved by activation of a PERK-independent eIF2alpha kinase through arsenite treatment and is independent of activating transcription factor 4 signaling and protein translation.	arsenite	118-126	eukaryotic translation initiation factor 2A	Homo sapiens	93-102
23000044-3	2012	However, persistent activation of Nrf2 in response to chronic oxidative stress, including inorganic arsenite (iAs3+) exposure, blunts glucose-triggered reactive oxygen species (ROS) signaling and impairs glucose-stimulated insulin secretion (GSIS).	arsenite	100-108	nuclear factor, erythroid derived 2, like 2	Mus musculus	34-38
22706169-3	2012	Our present study shows that, for human keratinocytes (HaCaT) cells, a low concentration of arsenite activates extracellular signal-regulated kinases (ERKs), which leads to up-regulation of nuclear factor kappaB (NF-kappaB) binding to DNA and to elevated, NF-kappaB-dependent expression of mot-2 (a p53 inhibitor) and survivin (an inhibitor of apoptosis).	arsenite	92-100	nuclear factor kappa B subunit 1	Homo sapiens	213-222
22706169-3	2012	Our present study shows that, for human keratinocytes (HaCaT) cells, a low concentration of arsenite activates extracellular signal-regulated kinases (ERKs), which leads to up-regulation of nuclear factor kappaB (NF-kappaB) binding to DNA and to elevated, NF-kappaB-dependent expression of mot-2 (a p53 inhibitor) and survivin (an inhibitor of apoptosis).	arsenite	92-100	nuclear factor kappa B subunit 1	Homo sapiens	256-265
22706169-3	2012	Our present study shows that, for human keratinocytes (HaCaT) cells, a low concentration of arsenite activates extracellular signal-regulated kinases (ERKs), which leads to up-regulation of nuclear factor kappaB (NF-kappaB) binding to DNA and to elevated, NF-kappaB-dependent expression of mot-2 (a p53 inhibitor) and survivin (an inhibitor of apoptosis).	arsenite	92-100	heat shock protein family A (Hsp70) member 9	Homo sapiens	290-295
22706169-3	2012	Our present study shows that, for human keratinocytes (HaCaT) cells, a low concentration of arsenite activates extracellular signal-regulated kinases (ERKs), which leads to up-regulation of nuclear factor kappaB (NF-kappaB) binding to DNA and to elevated, NF-kappaB-dependent expression of mot-2 (a p53 inhibitor) and survivin (an inhibitor of apoptosis).	arsenite	92-100	tumor protein p53	Homo sapiens	299-302
22706169-6	2012	In contrast, a high concentration of arsenite activates c-Jun N-terminal kinases (JNKs), positive regulators of p53, by binding to p53 and preventing its murine double minute 2 (mdm2)-mediated degradation.	arsenite	37-45	transformation related protein 53, pseudogene	Mus musculus	112-115
22706169-6	2012	In contrast, a high concentration of arsenite activates c-Jun N-terminal kinases (JNKs), positive regulators of p53, by binding to p53 and preventing its murine double minute 2 (mdm2)-mediated degradation.	arsenite	37-45	transformation related protein 53, pseudogene	Mus musculus	131-134
22706169-6	2012	In contrast, a high concentration of arsenite activates c-Jun N-terminal kinases (JNKs), positive regulators of p53, by binding to p53 and preventing its murine double minute 2 (mdm2)-mediated degradation.	arsenite	37-45	transformed mouse 3T3 cell double minute 2	Mus musculus	178-182
22706169-9	2012	By identifying a mechanism whereby ERKs and JNKs-mediated regulation of the p53-survivin signal pathway is involved in the biphasic effects of arsenite on human keratinocytes, our data expand understanding of arsenite-induced cell proliferation, neoplastic transformation, DNA damage, and apoptosis.	arsenite	143-151	tumor protein p53	Homo sapiens	76-79
22706169-9	2012	By identifying a mechanism whereby ERKs and JNKs-mediated regulation of the p53-survivin signal pathway is involved in the biphasic effects of arsenite on human keratinocytes, our data expand understanding of arsenite-induced cell proliferation, neoplastic transformation, DNA damage, and apoptosis.	arsenite	209-217	tumor protein p53	Homo sapiens	76-79
22745270-6	2012	The activation of Crz1 by arsenite culminates in the induction of the endogenous genes PMR1, PMC1 and GSC2.	arsenite	26-34	DNA-binding transcription factor CRZ1	Saccharomyces cerevisiae S288C	18-22
22824620-5	2012	Immunocytochemical staining and Western blotting results revealed increased expression of Caveolin-1, IKKbeta, and COX-2 but decreased eNOS in SV-HUC-1 cells treated with low concentration of arsenite.	arsenite	192-200	caveolin 1	Homo sapiens	90-100
22824620-5	2012	Immunocytochemical staining and Western blotting results revealed increased expression of Caveolin-1, IKKbeta, and COX-2 but decreased eNOS in SV-HUC-1 cells treated with low concentration of arsenite.	arsenite	192-200	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	102-109
22824620-5	2012	Immunocytochemical staining and Western blotting results revealed increased expression of Caveolin-1, IKKbeta, and COX-2 but decreased eNOS in SV-HUC-1 cells treated with low concentration of arsenite.	arsenite	192-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
22824620-5	2012	Immunocytochemical staining and Western blotting results revealed increased expression of Caveolin-1, IKKbeta, and COX-2 but decreased eNOS in SV-HUC-1 cells treated with low concentration of arsenite.	arsenite	192-200	nitric oxide synthase 3	Homo sapiens	135-139
22824620-6	2012	Additionally, MEK inhibitor (U0126) significantly attenuated arsenite-induced expression of Caveolin-1, IKKbeta and COX-2 while reducing eNOS expression.	arsenite	61-69	mitogen-activated protein kinase kinase 7	Homo sapiens	14-17
22824620-6	2012	Additionally, MEK inhibitor (U0126) significantly attenuated arsenite-induced expression of Caveolin-1, IKKbeta and COX-2 while reducing eNOS expression.	arsenite	61-69	caveolin 1	Homo sapiens	92-102
22824620-6	2012	Additionally, MEK inhibitor (U0126) significantly attenuated arsenite-induced expression of Caveolin-1, IKKbeta and COX-2 while reducing eNOS expression.	arsenite	61-69	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	104-111
22824620-6	2012	Additionally, MEK inhibitor (U0126) significantly attenuated arsenite-induced expression of Caveolin-1, IKKbeta and COX-2 while reducing eNOS expression.	arsenite	61-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
22824620-6	2012	Additionally, MEK inhibitor (U0126) significantly attenuated arsenite-induced expression of Caveolin-1, IKKbeta and COX-2 while reducing eNOS expression.	arsenite	61-69	nitric oxide synthase 3	Homo sapiens	137-141
22959463-8	2012	The arsenite-induced activation of the UPR was associated with an accumulation of protein aggregates containing p62 and LC3, proteins with established roles in the sequestration and autophagic clearance of protein aggregates.	arsenite	4-12	nucleoporin 62	Homo sapiens	112-115
22959463-8	2012	The arsenite-induced activation of the UPR was associated with an accumulation of protein aggregates containing p62 and LC3, proteins with established roles in the sequestration and autophagic clearance of protein aggregates.	arsenite	4-12	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	120-123
22771847-5	2012	In the present study, we have focused on the interaction of cellular PTPs with toxic trivalent arsenite (iAs(III)) and its intermediate metabolites such as monomethylarsonous acid (MMA(III)) and dimethylarsinous acid (DMA(III)) in vitro, and then determined the arsenic binding site in PTP by the use of recombinant PTPs (e.g., PTP1B and CD45).	arsenite	95-103	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	69-72
22771847-5	2012	In the present study, we have focused on the interaction of cellular PTPs with toxic trivalent arsenite (iAs(III)) and its intermediate metabolites such as monomethylarsonous acid (MMA(III)) and dimethylarsinous acid (DMA(III)) in vitro, and then determined the arsenic binding site in PTP by the use of recombinant PTPs (e.g., PTP1B and CD45).	arsenite	95-103	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	328-333
22771847-5	2012	In the present study, we have focused on the interaction of cellular PTPs with toxic trivalent arsenite (iAs(III)) and its intermediate metabolites such as monomethylarsonous acid (MMA(III)) and dimethylarsinous acid (DMA(III)) in vitro, and then determined the arsenic binding site in PTP by the use of recombinant PTPs (e.g., PTP1B and CD45).	arsenite	95-103	protein tyrosine phosphatase receptor type C	Homo sapiens	338-342
22887765-0	2012	Analysis of neuroglobin mRNA expression in rat brain due to arsenite-induced oxidative stress.	arsenite	60-68	neuroglobin	Rattus norvegicus	12-23
22887765-8	2012	Ngb may play a protective role in cerebellum when oxidative stress occurs due to arsenite exposure.	arsenite	81-89	neuroglobin	Rattus norvegicus	0-3
22562211-6	2012	Thus, functional predictions suggest that the ACR2 protein is involved in the conversion of arsenate to arsenite in plant cells.	arsenite	104-112	Rhodanese/Cell cycle control phosphatase superfamily protein	Arabidopsis thaliana	46-50
22745270-5	2012	In response to an arsenite-induced increase of Ca(2+) in the cytosol, Crz1 is dephosphorylated and translocated to the nucleus, and stimulates CDRE-driven expression of the lacZ reporter gene in a Cnb1-dependent manner.	arsenite	18-26	DNA-binding transcription factor CRZ1	Saccharomyces cerevisiae S288C	70-74
22745270-5	2012	In response to an arsenite-induced increase of Ca(2+) in the cytosol, Crz1 is dephosphorylated and translocated to the nucleus, and stimulates CDRE-driven expression of the lacZ reporter gene in a Cnb1-dependent manner.	arsenite	18-26	calcineurin regulatory subunit B	Saccharomyces cerevisiae S288C	197-201
22745270-6	2012	The activation of Crz1 by arsenite culminates in the induction of the endogenous genes PMR1, PMC1 and GSC2.	arsenite	26-34	Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1	Saccharomyces cerevisiae S288C	87-91
22745270-6	2012	The activation of Crz1 by arsenite culminates in the induction of the endogenous genes PMR1, PMC1 and GSC2.	arsenite	26-34	calcium-transporting ATPase PMC1	Saccharomyces cerevisiae S288C	93-97
22550998-3	2012	In this study real-time PCR, western analysis, immunostaining and fluorescent localization were used to define the expression of ZIP8 in human kidney, cultured human proximal tubule (HPT) cells, normal and malignant human urothelium and Cd+2 and arsenite (As+3) transformed urothelial cells.	arsenite	246-254	solute carrier family 39 member 8	Homo sapiens	129-133
22745270-6	2012	The activation of Crz1 by arsenite culminates in the induction of the endogenous genes PMR1, PMC1 and GSC2.	arsenite	26-34	1,3-beta-glucan synthase GSC2	Saccharomyces cerevisiae S288C	102-106
22641621-8	2012	Interestingly, the expression of Nanog, a transcription factor that maintains the pluripotency of stem cells, was increased after arsenite exposure, indicating that arsenite inhibits their differentiation but not proliferation.	arsenite	130-138	Nanog homeobox	Mus musculus	33-38
22641621-8	2012	Interestingly, the expression of Nanog, a transcription factor that maintains the pluripotency of stem cells, was increased after arsenite exposure, indicating that arsenite inhibits their differentiation but not proliferation.	arsenite	165-173	Nanog homeobox	Mus musculus	33-38
22703473-2	2012	Irradiation of the arsenite/goethite under conditions where dissolved oxygen was present in solution led to the presence of arsenate (As(V)) product adsorbed on goethite and in solution.	arsenite	19-27	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	134-139
22613180-2	2012	This laboratory has shown that ENO2 might be a biomarker for exposure to cadmium and arsenite.	arsenite	85-93	enolase 2	Homo sapiens	31-35
22613031-4	2012	Here, real-time quantitative RT-PCR and whole-mount in situ hybridization data showed that zebrafish Dvr1, a mammalian homolog of GDF1 related to the formation of left-right axis, was significantly down-regulated in embryos exposed to arsenite.	arsenite	235-243	growth differentiation factor 3	Danio rerio	101-105
22613031-4	2012	Here, real-time quantitative RT-PCR and whole-mount in situ hybridization data showed that zebrafish Dvr1, a mammalian homolog of GDF1 related to the formation of left-right axis, was significantly down-regulated in embryos exposed to arsenite.	arsenite	235-243	growth differentiation factor 1	Homo sapiens	130-134
22613031-6	2012	Furthermore, overexpression of GDF1 significantly rescued development anomalies caused by morpholino or arsenite.	arsenite	104-112	growth differentiation factor 1	Homo sapiens	31-35
22526669-2	2012	The samples were subjected to microwave-assisted extraction using diluted hydrochloric acid and hydrogen peroxide, which solubilised the analytes and oxidised arsenite (As(III)) to arsenate (As(V)).	arsenite	159-167	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	191-196
22555848-4	2012	Increasing the levels of cellular polyamines by ectopic overexpression of the ornithine decarboxylase gene decreased cytoplasmic levels of SG-signature constituent proteins eukaryotic initiation factor 3b and T-cell intracellular antigen-1 (TIA-1)-related protein and repressed the assembly of SGs induced by exposure to arsenite-induced oxidative stress.	arsenite	321-329	ornithine decarboxylase 1	Homo sapiens	78-101
22555848-5	2012	In contrast, depletion of cellular polyamines by inhibiting ornithine decarboxylase with alpha-difluoromethylornithine increased cytoplasmic eukaryotic initiation factor 3b and TIA-1 related protein abundance and enhanced arsenite-induced SG assembly.	arsenite	222-230	ornithine decarboxylase 1	Homo sapiens	60-83
22463588-0	2012	Cyclooxygenase-2 (COX-2) mediates arsenite inhibition of UVB-induced cellular apoptosis in mouse epidermal Cl41 cells.	arsenite	34-42	prostaglandin-endoperoxide synthase 2	Mus musculus	0-16
22463588-0	2012	Cyclooxygenase-2 (COX-2) mediates arsenite inhibition of UVB-induced cellular apoptosis in mouse epidermal Cl41 cells.	arsenite	34-42	prostaglandin-endoperoxide synthase 2	Mus musculus	18-23
22463588-6	2012	We found that treatment of cells with low concentration (5 muM) arsenite attenuated cellular apoptosis upon UVB radiation accompanied with a coinductive effect on COX-2 expression and nuclear factor-kappaB (NFkappaB) transactivation.	arsenite	64-72	prostaglandin-endoperoxide synthase 2	Mus musculus	163-168
22463588-6	2012	We found that treatment of cells with low concentration (5 muM) arsenite attenuated cellular apoptosis upon UVB radiation accompanied with a coinductive effect on COX-2 expression and nuclear factor-kappaB (NFkappaB) transactivation.	arsenite	64-72	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	207-215
22463588-7	2012	Our results also showed that the COX-2 induction by arsenite and UVB depended on an NFkappaB pathway because COX-2 co-induction could be attenuated in either p65-deficient or p50-deficient cells.	arsenite	52-60	prostaglandin-endoperoxide synthase 2	Mus musculus	33-38
22463588-7	2012	Our results also showed that the COX-2 induction by arsenite and UVB depended on an NFkappaB pathway because COX-2 co-induction could be attenuated in either p65-deficient or p50-deficient cells.	arsenite	52-60	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	84-92
22463588-7	2012	Our results also showed that the COX-2 induction by arsenite and UVB depended on an NFkappaB pathway because COX-2 co-induction could be attenuated in either p65-deficient or p50-deficient cells.	arsenite	52-60	prostaglandin-endoperoxide synthase 2	Mus musculus	109-114
22463588-7	2012	Our results also showed that the COX-2 induction by arsenite and UVB depended on an NFkappaB pathway because COX-2 co-induction could be attenuated in either p65-deficient or p50-deficient cells.	arsenite	52-60	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	158-161
22463588-7	2012	Our results also showed that the COX-2 induction by arsenite and UVB depended on an NFkappaB pathway because COX-2 co-induction could be attenuated in either p65-deficient or p50-deficient cells.	arsenite	52-60	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	175-178
22463588-8	2012	Moreover, UVB-induced cell apoptosis could be dramatically reduced by the introduction of exogenous COX-2 expression, whereas the inhibitory effect of arsenite on UVB-induced cell apoptosis could be impaired in COX-2 knockdown C141 cells.	arsenite	151-159	prostaglandin-endoperoxide synthase 2	Mus musculus	211-216
22463588-9	2012	Our results indicated that COX-2 mediated the anti-apoptotic effect of arsenite in UVB radiation through an NFkappaB-dependent pathway.	arsenite	71-79	prostaglandin-endoperoxide synthase 2	Mus musculus	27-32
22463588-9	2012	Our results indicated that COX-2 mediated the anti-apoptotic effect of arsenite in UVB radiation through an NFkappaB-dependent pathway.	arsenite	71-79	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	108-116
22463588-10	2012	Given the importance of apoptosis evasion during carcinogenesis, we anticipated that COX-2 induction might be at least partially responsible for the co-carcinogenic effect of arsenite on UVB-induced skin carcinogenesis.	arsenite	175-183	prostaglandin-endoperoxide synthase 2	Mus musculus	85-90
22521605-0	2012	Arsenite activates NFkappaB through induction of C-reactive protein.	arsenite	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	19-27
22496356-1	2012	Heat shock factor 1 (HSF1) is a key regulator of the cytoprotective and anti-apoptotic heat shock response and can be activated by arsenite.	arsenite	131-139	heat shock transcription factor 1	Homo sapiens	0-19
22496356-1	2012	Heat shock factor 1 (HSF1) is a key regulator of the cytoprotective and anti-apoptotic heat shock response and can be activated by arsenite.	arsenite	131-139	heat shock transcription factor 1	Homo sapiens	21-25
22577148-6	2012	Moreover, cells induced to undergo apoptosis by arsenite show increased R-CRT on their cell surface.	arsenite	48-56	calreticulin	Homo sapiens	72-77
22521605-0	2012	Arsenite activates NFkappaB through induction of C-reactive protein.	arsenite	0-8	C-reactive protein, pentraxin-related	Mus musculus	49-67
22521605-5	2012	In this study we show that exposure of the hepatic cell line, HepG2, to environmentally relevant levels of arsenite (0.13 to 2 muM) results in elevated CRP expression and secretion.	arsenite	107-115	C-reactive protein, pentraxin-related	Mus musculus	152-155
22421273-6	2012	Decreased protein expression of NR2A, PSD-95 and p-CaMKII alpha in the hippocampus of arsenite-exposed rats was observed, while the expression of SynGAP, a negative regulator of Ras-MAPK activity, was increased when compared with the controls.	arsenite	86-94	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	32-36
22447124-0	2012	Blockade of p53 by HIF-2alpha, but not HIF-1alpha, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells.	arsenite	66-74	tumor protein p53	Homo sapiens	12-15
22447124-0	2012	Blockade of p53 by HIF-2alpha, but not HIF-1alpha, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells.	arsenite	66-74	endothelial PAS domain protein 1	Homo sapiens	19-29
22447124-7	2012	The present report demonstrates that, with increased time of exposure to arsenite, there is more increased expression of HIF-2alpha, but not HIF-1alpha.	arsenite	73-81	endothelial PAS domain protein 1	Homo sapiens	121-131
22447124-7	2012	The present report demonstrates that, with increased time of exposure to arsenite, there is more increased expression of HIF-2alpha, but not HIF-1alpha.	arsenite	73-81	hypoxia inducible factor 1 subunit alpha	Homo sapiens	141-151
22447124-9	2012	Arsenite induces accumulation of HIF-2alpha by inhibiting its degradation through the ubiquitin-mediated proteasome pathway.	arsenite	0-8	endothelial PAS domain protein 1	Homo sapiens	33-43
22447124-11	2012	Finally, inhibition of HIF-2alpha blocks arsenite-induced proliferation and malignant transformation.	arsenite	41-49	endothelial PAS domain protein 1	Homo sapiens	23-33
22447124-12	2012	Thus, our studies show that blockade of p53 function by inhibiting the ubiquitin-mediated proteasome degradation of HIF-2alpha, but not that of HIF-1alpha, is involved in arsenite-induced proliferation and neoplastic transformation of HBE cells.	arsenite	171-179	tumor protein p53	Homo sapiens	40-43
22447124-12	2012	Thus, our studies show that blockade of p53 function by inhibiting the ubiquitin-mediated proteasome degradation of HIF-2alpha, but not that of HIF-1alpha, is involved in arsenite-induced proliferation and neoplastic transformation of HBE cells.	arsenite	171-179	endothelial PAS domain protein 1	Homo sapiens	116-126
22421273-6	2012	Decreased protein expression of NR2A, PSD-95 and p-CaMKII alpha in the hippocampus of arsenite-exposed rats was observed, while the expression of SynGAP, a negative regulator of Ras-MAPK activity, was increased when compared with the controls.	arsenite	86-94	discs large MAGUK scaffold protein 4	Rattus norvegicus	38-44
22421273-6	2012	Decreased protein expression of NR2A, PSD-95 and p-CaMKII alpha in the hippocampus of arsenite-exposed rats was observed, while the expression of SynGAP, a negative regulator of Ras-MAPK activity, was increased when compared with the controls.	arsenite	86-94	synaptic Ras GTPase activating protein 1	Rattus norvegicus	146-152
22421273-6	2012	Decreased protein expression of NR2A, PSD-95 and p-CaMKII alpha in the hippocampus of arsenite-exposed rats was observed, while the expression of SynGAP, a negative regulator of Ras-MAPK activity, was increased when compared with the controls.	arsenite	86-94	mitogen activated protein kinase 3	Rattus norvegicus	182-186
22421273-7	2012	Additionally, decreased p-ERK1/2 activity was found in the hippocampus of arsenite-exposed rats.	arsenite	74-82	mitogen activated protein kinase 3	Rattus norvegicus	26-32
22366412-0	2012	DNA-PKcs-mediated stabilization of p53 by JNK2 is involved in arsenite-induced DNA damage and apoptosis in human embryo lung fibroblast cells.	arsenite	62-70	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	0-8
22366412-0	2012	DNA-PKcs-mediated stabilization of p53 by JNK2 is involved in arsenite-induced DNA damage and apoptosis in human embryo lung fibroblast cells.	arsenite	62-70	tumor protein p53	Homo sapiens	35-38
22366412-0	2012	DNA-PKcs-mediated stabilization of p53 by JNK2 is involved in arsenite-induced DNA damage and apoptosis in human embryo lung fibroblast cells.	arsenite	62-70	mitogen-activated protein kinase 9	Homo sapiens	42-46
22366412-4	2012	Here, we find that, in human embryo lung fibroblast (HELF) cells, arsenite induces the activation of dependent protein kinase catalytic subunit (DNA-PKcs), which then phosphorylates and activates c-Jun N-terminal kinases 2 (JNK2), but not JNK1.	arsenite	66-74	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	145-153
22366412-4	2012	Here, we find that, in human embryo lung fibroblast (HELF) cells, arsenite induces the activation of dependent protein kinase catalytic subunit (DNA-PKcs), which then phosphorylates and activates c-Jun N-terminal kinases 2 (JNK2), but not JNK1.	arsenite	66-74	mitogen-activated protein kinase 9	Homo sapiens	196-222
22366412-4	2012	Here, we find that, in human embryo lung fibroblast (HELF) cells, arsenite induces the activation of dependent protein kinase catalytic subunit (DNA-PKcs), which then phosphorylates and activates c-Jun N-terminal kinases 2 (JNK2), but not JNK1.	arsenite	66-74	mitogen-activated protein kinase 9	Homo sapiens	224-228
22366412-4	2012	Here, we find that, in human embryo lung fibroblast (HELF) cells, arsenite induces the activation of dependent protein kinase catalytic subunit (DNA-PKcs), which then phosphorylates and activates c-Jun N-terminal kinases 2 (JNK2), but not JNK1.	arsenite	66-74	mitogen-activated protein kinase 8	Homo sapiens	239-243
22366412-6	2012	Knockdown of DNA-PKcs/JNK2 signal pathway or p53 reduces apoptosis but elevates the DNA damage induced by a high level of arsenite.	arsenite	122-130	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	13-21
22366412-6	2012	Knockdown of DNA-PKcs/JNK2 signal pathway or p53 reduces apoptosis but elevates the DNA damage induced by a high level of arsenite.	arsenite	122-130	mitogen-activated protein kinase 9	Homo sapiens	22-26
22366412-6	2012	Knockdown of DNA-PKcs/JNK2 signal pathway or p53 reduces apoptosis but elevates the DNA damage induced by a high level of arsenite.	arsenite	122-130	tumor protein p53	Homo sapiens	45-48
22551203-6	2012	In the in vitro study, human lymphoblasts were treated with arsenite at 0-100 muM for two, four and eight hours (short-term) and at 0, 0.5 and 1.0 muM for eight-weeks period (long-term).	arsenite	60-68	latexin	Homo sapiens	78-81
22551203-11	2012	Short-term in vitro arsenite treatment in lymphoblastoid cells clearly demonstrated a significant global hypomethylation, determined as reduction in LINE-1 methylation and total 5-MedC content, and p53 hypermethylation (p < 0.05).	arsenite	20-28	tumor protein p53	Homo sapiens	198-201
22366412-7	2012	These results suggest that DNA-PKcs-mediated stabilization of p53 by JNK2 is involved in arsenite-induced DNA damage and apoptosis.	arsenite	89-97	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	27-35
22366412-7	2012	These results suggest that DNA-PKcs-mediated stabilization of p53 by JNK2 is involved in arsenite-induced DNA damage and apoptosis.	arsenite	89-97	tumor protein p53	Homo sapiens	62-65
22366412-7	2012	These results suggest that DNA-PKcs-mediated stabilization of p53 by JNK2 is involved in arsenite-induced DNA damage and apoptosis.	arsenite	89-97	mitogen-activated protein kinase 9	Homo sapiens	69-73
22380876-0	2012	Heterologous expression of the yeast arsenite efflux system ACR3 improves Arabidopsis thaliana tolerance to arsenic stress.	arsenite	37-45	Arr3p	Saccharomyces cerevisiae S288C	60-64
22387281-0	2012	Regulation of miRNA-21 by reactive oxygen species-activated ERK/NF-kappaB in arsenite-induced cell transformation.	arsenite	77-85	microRNA 21	Homo sapiens	14-22
22387281-0	2012	Regulation of miRNA-21 by reactive oxygen species-activated ERK/NF-kappaB in arsenite-induced cell transformation.	arsenite	77-85	mitogen-activated protein kinase 1	Homo sapiens	60-63
22387281-0	2012	Regulation of miRNA-21 by reactive oxygen species-activated ERK/NF-kappaB in arsenite-induced cell transformation.	arsenite	77-85	nuclear factor kappa B subunit 1	Homo sapiens	64-73
22387281-4	2012	The purpose of this study was to determine if miR-21 is involved in arsenite-induced malignant transformation and to characterize the associated signaling pathways.	arsenite	68-76	microRNA 21	Homo sapiens	46-52
22387281-5	2012	During arsenite-induced transformation of human embryo lung fibroblast (HELF) cells, miR-21 was upregulated, and the extracellular signal-regulated kinase (ERK)/nuclear factor-kappaB (NF-kappaB) signal pathway was activated.	arsenite	7-15	microRNA 21	Homo sapiens	85-91
22387281-5	2012	During arsenite-induced transformation of human embryo lung fibroblast (HELF) cells, miR-21 was upregulated, and the extracellular signal-regulated kinase (ERK)/nuclear factor-kappaB (NF-kappaB) signal pathway was activated.	arsenite	7-15	mitogen-activated protein kinase 1	Homo sapiens	156-159
22387281-5	2012	During arsenite-induced transformation of human embryo lung fibroblast (HELF) cells, miR-21 was upregulated, and the extracellular signal-regulated kinase (ERK)/nuclear factor-kappaB (NF-kappaB) signal pathway was activated.	arsenite	7-15	nuclear factor kappa B subunit 1	Homo sapiens	184-193
22387281-7	2012	Blockage of ERK by the inhibitor U0126 or inhibition of NF-kappaB p65 by siRNA or Bay 11-7082 prevented the increases in miR-21 and the decreases in Spry1, Pten, and Pdcd4, the target proteins of miR-21, induced by arsenite.	arsenite	215-223	mitogen-activated protein kinase 1	Homo sapiens	12-15
22387281-7	2012	Blockage of ERK by the inhibitor U0126 or inhibition of NF-kappaB p65 by siRNA or Bay 11-7082 prevented the increases in miR-21 and the decreases in Spry1, Pten, and Pdcd4, the target proteins of miR-21, induced by arsenite.	arsenite	215-223	nuclear factor kappa B subunit 1	Homo sapiens	56-65
22387281-7	2012	Blockage of ERK by the inhibitor U0126 or inhibition of NF-kappaB p65 by siRNA or Bay 11-7082 prevented the increases in miR-21 and the decreases in Spry1, Pten, and Pdcd4, the target proteins of miR-21, induced by arsenite.	arsenite	215-223	microRNA 21	Homo sapiens	121-127
22367689-0	2012	Histone deacetylase 6 associates with ribosomes and regulates de novo protein translation during arsenite stress.	arsenite	97-105	histone deacetylase 6	Homo sapiens	0-21
22387281-9	2012	Further, anti-miR-21 downregulated miR-21 expression and prevented the arsenite-induced activation of ERK via the increase in Spry1, indicating that miR-21 has a feedback effect in regulating ERK activation.	arsenite	71-79	microRNA 21	Homo sapiens	14-20
22387281-9	2012	Further, anti-miR-21 downregulated miR-21 expression and prevented the arsenite-induced activation of ERK via the increase in Spry1, indicating that miR-21 has a feedback effect in regulating ERK activation.	arsenite	71-79	microRNA 21	Homo sapiens	35-41
22387281-9	2012	Further, anti-miR-21 downregulated miR-21 expression and prevented the arsenite-induced activation of ERK via the increase in Spry1, indicating that miR-21 has a feedback effect in regulating ERK activation.	arsenite	71-79	mitogen-activated protein kinase 1	Homo sapiens	102-105
22387281-9	2012	Further, anti-miR-21 downregulated miR-21 expression and prevented the arsenite-induced activation of ERK via the increase in Spry1, indicating that miR-21 has a feedback effect in regulating ERK activation.	arsenite	71-79	sprouty RTK signaling antagonist 1	Homo sapiens	126-131
22387281-9	2012	Further, anti-miR-21 downregulated miR-21 expression and prevented the arsenite-induced activation of ERK via the increase in Spry1, indicating that miR-21 has a feedback effect in regulating ERK activation.	arsenite	71-79	microRNA 21	Homo sapiens	35-41
22387281-9	2012	Further, anti-miR-21 downregulated miR-21 expression and prevented the arsenite-induced activation of ERK via the increase in Spry1, indicating that miR-21 has a feedback effect in regulating ERK activation.	arsenite	71-79	mitogen-activated protein kinase 1	Homo sapiens	192-195
22387281-10	2012	Overexpression of miR-21 with an miR-21 mimic and feedback activation of ERK and NF-kappaB via the decrease in Spry1 promoted the malignancy of HELF cells exposed to arsenite, but knockdown of miR-21 with anti-miR-21 and feedback blockage of ERK and NF-kappaB activation through an increase in Spry1 decreased anchorage-independent growth of arsenite-transformed cells.	arsenite	166-174	microRNA 21	Homo sapiens	18-24
22387281-10	2012	Overexpression of miR-21 with an miR-21 mimic and feedback activation of ERK and NF-kappaB via the decrease in Spry1 promoted the malignancy of HELF cells exposed to arsenite, but knockdown of miR-21 with anti-miR-21 and feedback blockage of ERK and NF-kappaB activation through an increase in Spry1 decreased anchorage-independent growth of arsenite-transformed cells.	arsenite	166-174	mitogen-activated protein kinase 1	Homo sapiens	73-76
22387281-10	2012	Overexpression of miR-21 with an miR-21 mimic and feedback activation of ERK and NF-kappaB via the decrease in Spry1 promoted the malignancy of HELF cells exposed to arsenite, but knockdown of miR-21 with anti-miR-21 and feedback blockage of ERK and NF-kappaB activation through an increase in Spry1 decreased anchorage-independent growth of arsenite-transformed cells.	arsenite	342-350	microRNA 21	Homo sapiens	18-24
22387281-11	2012	Thus, the transformation of HELF cells induced by chronic exposure to arsenite is mediated by increased miR-21 expression, which, in turn, is mediated by reactive oxygen species activation of the ERK/NF-kappaB pathway.	arsenite	70-78	microRNA 21	Homo sapiens	104-110
22387281-11	2012	Thus, the transformation of HELF cells induced by chronic exposure to arsenite is mediated by increased miR-21 expression, which, in turn, is mediated by reactive oxygen species activation of the ERK/NF-kappaB pathway.	arsenite	70-78	mitogen-activated protein kinase 1	Homo sapiens	196-199
22387281-11	2012	Thus, the transformation of HELF cells induced by chronic exposure to arsenite is mediated by increased miR-21 expression, which, in turn, is mediated by reactive oxygen species activation of the ERK/NF-kappaB pathway.	arsenite	70-78	nuclear factor kappa B subunit 1	Homo sapiens	200-209
22367689-4	2012	Separation of ribosomal subunits versus intact ribosomes or polysomes indicated that HDAC6 was mainly detected in 40/43S fractions containing the small ribosomal subunit in untreated cells but was associated with 40/43S and 60/80S ribosomal fractions in arsenite-treated cells.	arsenite	254-262	histone deacetylase 6	Homo sapiens	85-90
22367689-5	2012	Immunocytochemistry studies revealed that arsenite caused colocalization of HDAC6 with the ribosomal large and small subunit protein L36a and S6.	arsenite	42-50	histone deacetylase 6	Homo sapiens	76-81
22367689-6	2012	Both L36a and S6 were detected in the immunocomplex of HDAC6 isolated from arsenite-treated cells.	arsenite	75-83	histone deacetylase 6	Homo sapiens	55-60
22367689-8	2012	Among arsenite stress-induced proteins, de novo Nrf2 protein translation was inhibited by Tubastatin A.	arsenite	6-14	NFE2 like bZIP transcription factor 2	Homo sapiens	48-52
22367689-9	2012	These data demonstrate that HDAC6 was recruited to ribosomes, physically interacted with ribosomal proteins, and regulated de novo protein translation in keratinocytes responding to arsenite stress.	arsenite	182-190	histone deacetylase 6	Homo sapiens	28-33
22387748-0	2012	Poly(ADP-ribose) polymerase-1 inhibition by arsenite promotes the survival of cells with unrepaired DNA lesions induced by UV exposure.	arsenite	44-52	poly(ADP-ribose) polymerase 1	Homo sapiens	0-29
22387748-3	2012	We have previously demonstrated that low concentrations of arsenite inhibit poly(ADP-ribose) polymerase (PARP)-1, thus interfering with DNA repair process triggered by UV radiation.	arsenite	59-67	poly(ADP-ribose) polymerase 1	Homo sapiens	76-112
22387748-10	2012	Notably, knockdown of PARP-1 with small interfering RNA completely abolished the antagonism of arsenite.	arsenite	95-103	poly(ADP-ribose) polymerase 1	Homo sapiens	22-28
22387748-12	2012	Together, these results suggest that low concentration of arsenite reduces UV-induced apoptosis via inhibiting PARP-1, thus promoting the survival of cells with unrepaired DNA lesions, which may be an important mechanism underlying arsenic cocarcinogenic action.	arsenite	58-66	poly(ADP-ribose) polymerase 1	Homo sapiens	111-117
22492492-8	2012	The cytotoxicity of arsenite was augmented by p38 MAP kinase inhibitor SB202190 and HO-1 inhibitor tin protoporphyrin IX (SnPP), whereas p38 MAP kinase inhibitor SB202190 also inhibited HO-1 induction by NaAsO(2) .	arsenite	20-28	mitogen-activated protein kinase 14	Homo sapiens	46-49
22452989-7	2012	Targeted knockdown of HRI or G3BP, a protein required for SG assembly, inhibits spontaneous and arsenite-induced assembly of SGs in erythroid progenitor cells.	arsenite	96-104	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	22-25
22452989-7	2012	Targeted knockdown of HRI or G3BP, a protein required for SG assembly, inhibits spontaneous and arsenite-induced assembly of SGs in erythroid progenitor cells.	arsenite	96-104	G3BP stress granule assembly factor 1	Homo sapiens	29-33
22492492-8	2012	The cytotoxicity of arsenite was augmented by p38 MAP kinase inhibitor SB202190 and HO-1 inhibitor tin protoporphyrin IX (SnPP), whereas p38 MAP kinase inhibitor SB202190 also inhibited HO-1 induction by NaAsO(2) .	arsenite	20-28	heme oxygenase 1	Homo sapiens	84-88
22492492-8	2012	The cytotoxicity of arsenite was augmented by p38 MAP kinase inhibitor SB202190 and HO-1 inhibitor tin protoporphyrin IX (SnPP), whereas p38 MAP kinase inhibitor SB202190 also inhibited HO-1 induction by NaAsO(2) .	arsenite	20-28	heme oxygenase 1	Homo sapiens	186-190
22310326-5	2012	Our work has shown that arsenite decreases nuclear levels of RXRalpha the nuclear receptor that, as a heterodimer partner with PXR, transactivates the CYP3A gene.	arsenite	24-32	retinoid X receptor alpha	Homo sapiens	61-69
22720424-2	2012	Photocatalysis can rapidly oxidize arsenite, i.e. As(III), to less labile arsenate, i.e. As(V), which then can be removed by adsorption on to various adsorbents.	arsenite	35-43	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	89-94
22310326-5	2012	Our work has shown that arsenite decreases nuclear levels of RXRalpha the nuclear receptor that, as a heterodimer partner with PXR, transactivates the CYP3A gene.	arsenite	24-32	nuclear receptor subfamily 1 group I member 2	Homo sapiens	127-130
22310326-5	2012	Our work has shown that arsenite decreases nuclear levels of RXRalpha the nuclear receptor that, as a heterodimer partner with PXR, transactivates the CYP3A gene.	arsenite	24-32	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	151-156
22310326-6	2012	These results suggest that arsenite decreases transcription of CYP3A by decreasing RXRalpha.	arsenite	27-35	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	63-68
22310326-6	2012	These results suggest that arsenite decreases transcription of CYP3A by decreasing RXRalpha.	arsenite	27-35	retinoid X receptor alpha	Homo sapiens	83-91
22310326-7	2012	The present report shows that exposure to 5 muM arsenite decreased the activity of a rat CYP3A promoter luciferase reporter in HepG2 cells.	arsenite	48-56	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	89-94
22310326-10	2012	When rifampicin-treated primary human hepatocyte cultures were exposed to arsenite concentrations as low as 50 nM, CYP3A mRNA was decreased.	arsenite	74-82	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	115-120
22310326-13	2012	Surprisingly, we show that in hepatocytes arsenite decreases expression of two inflammatory mediators, TNF and VEGF, an effect that is not predicted from suppression of RXRalpha activity.	arsenite	42-50	tumor necrosis factor	Homo sapiens	103-106
22476201-4	2012	RESULTS: In human keratinocyte HaCaT cells, selective knockdown (KD) of NRF2 by lentiviral short hairpin RNAs (shRNAs) significantly reduced the expression of many antioxidant enzymes and sensitized the cells to acute cytotoxicity of inorganic arsenite (iAs(3+)).	arsenite	244-252	NFE2 like bZIP transcription factor 2	Homo sapiens	72-76
22310326-13	2012	Surprisingly, we show that in hepatocytes arsenite decreases expression of two inflammatory mediators, TNF and VEGF, an effect that is not predicted from suppression of RXRalpha activity.	arsenite	42-50	vascular endothelial growth factor A	Homo sapiens	111-115
22244921-3	2012	Pretreatment with U-73122 (a specific PLC inhibitor) or 2-APB (a specific IP3 receptor antagonist) attenuated this effect, suggesting that PLC/IP3 signaling cascade is involved in arsenite-induced elevation of [Ca2+]i. Cytotoxic concentrations of arsenite (5 and 10 muM) significantly enhanced endothelial nitric oxide synthase (eNOS) phosphorylation, nitric oxide (NO) production and apoptosis after 24-h exposure.	arsenite	180-188	heparan sulfate proteoglycan 2	Homo sapiens	38-41
22244921-3	2012	Pretreatment with U-73122 (a specific PLC inhibitor) or 2-APB (a specific IP3 receptor antagonist) attenuated this effect, suggesting that PLC/IP3 signaling cascade is involved in arsenite-induced elevation of [Ca2+]i. Cytotoxic concentrations of arsenite (5 and 10 muM) significantly enhanced endothelial nitric oxide synthase (eNOS) phosphorylation, nitric oxide (NO) production and apoptosis after 24-h exposure.	arsenite	180-188	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	74-86
22244921-3	2012	Pretreatment with U-73122 (a specific PLC inhibitor) or 2-APB (a specific IP3 receptor antagonist) attenuated this effect, suggesting that PLC/IP3 signaling cascade is involved in arsenite-induced elevation of [Ca2+]i. Cytotoxic concentrations of arsenite (5 and 10 muM) significantly enhanced endothelial nitric oxide synthase (eNOS) phosphorylation, nitric oxide (NO) production and apoptosis after 24-h exposure.	arsenite	180-188	heparan sulfate proteoglycan 2	Homo sapiens	139-142
22244921-3	2012	Pretreatment with U-73122 (a specific PLC inhibitor) or 2-APB (a specific IP3 receptor antagonist) attenuated this effect, suggesting that PLC/IP3 signaling cascade is involved in arsenite-induced elevation of [Ca2+]i. Cytotoxic concentrations of arsenite (5 and 10 muM) significantly enhanced endothelial nitric oxide synthase (eNOS) phosphorylation, nitric oxide (NO) production and apoptosis after 24-h exposure.	arsenite	180-188	latexin	Homo sapiens	266-269
22244921-3	2012	Pretreatment with U-73122 (a specific PLC inhibitor) or 2-APB (a specific IP3 receptor antagonist) attenuated this effect, suggesting that PLC/IP3 signaling cascade is involved in arsenite-induced elevation of [Ca2+]i. Cytotoxic concentrations of arsenite (5 and 10 muM) significantly enhanced endothelial nitric oxide synthase (eNOS) phosphorylation, nitric oxide (NO) production and apoptosis after 24-h exposure.	arsenite	180-188	nitric oxide synthase 3	Homo sapiens	294-327
22244921-3	2012	Pretreatment with U-73122 (a specific PLC inhibitor) or 2-APB (a specific IP3 receptor antagonist) attenuated this effect, suggesting that PLC/IP3 signaling cascade is involved in arsenite-induced elevation of [Ca2+]i. Cytotoxic concentrations of arsenite (5 and 10 muM) significantly enhanced endothelial nitric oxide synthase (eNOS) phosphorylation, nitric oxide (NO) production and apoptosis after 24-h exposure.	arsenite	247-255	heparan sulfate proteoglycan 2	Homo sapiens	139-142
22244921-5	2012	Moreover, we also found that non-apoptotic concentrations of arsenite (0.5 and 1 muM) dramatically mitigated thrombin-induced rapid transient rise of [Ca2+]i, eNOS phosphorylation and NO production, suggesting functional disruption of endothelial by arsenite, and these effects occurred without an alteration of PLC-beta1 and thrombin receptor levels.	arsenite	61-69	latexin	Homo sapiens	81-84
22244921-5	2012	Moreover, we also found that non-apoptotic concentrations of arsenite (0.5 and 1 muM) dramatically mitigated thrombin-induced rapid transient rise of [Ca2+]i, eNOS phosphorylation and NO production, suggesting functional disruption of endothelial by arsenite, and these effects occurred without an alteration of PLC-beta1 and thrombin receptor levels.	arsenite	61-69	coagulation factor II, thrombin	Homo sapiens	109-117
22244921-5	2012	Moreover, we also found that non-apoptotic concentrations of arsenite (0.5 and 1 muM) dramatically mitigated thrombin-induced rapid transient rise of [Ca2+]i, eNOS phosphorylation and NO production, suggesting functional disruption of endothelial by arsenite, and these effects occurred without an alteration of PLC-beta1 and thrombin receptor levels.	arsenite	61-69	phospholipase C beta 1	Homo sapiens	312-321
22244921-5	2012	Moreover, we also found that non-apoptotic concentrations of arsenite (0.5 and 1 muM) dramatically mitigated thrombin-induced rapid transient rise of [Ca2+]i, eNOS phosphorylation and NO production, suggesting functional disruption of endothelial by arsenite, and these effects occurred without an alteration of PLC-beta1 and thrombin receptor levels.	arsenite	61-69	coagulation factor II, thrombin	Homo sapiens	326-334
22244921-5	2012	Moreover, we also found that non-apoptotic concentrations of arsenite (0.5 and 1 muM) dramatically mitigated thrombin-induced rapid transient rise of [Ca2+]i, eNOS phosphorylation and NO production, suggesting functional disruption of endothelial by arsenite, and these effects occurred without an alteration of PLC-beta1 and thrombin receptor levels.	arsenite	250-258	coagulation factor II, thrombin	Homo sapiens	109-117
22244921-6	2012	Altogether, the results reveal that arsenite induces apoptotic cell death and endothelial dysfunction as indicated by the reduction of thrombin responses, particularly related to an alteration of intracellular Ca2+ homeostasis.	arsenite	36-44	coagulation factor II, thrombin	Homo sapiens	135-143
22240577-6	2012	Here we show that Tudor-SN localizes to cytoplasmic stress granules in HeLa cells undergoing arsenite-induced oxidative stress, or following transfection with long dsRNA (poly[IC]), which initiates an interferon cascade.	arsenite	93-101	staphylococcal nuclease and tudor domain containing 1	Homo sapiens	18-26
22260869-0	2012	Arsenite-induced apoptosis of human neuroblastoma cells requires p53 but occurs independently of c-Jun.	arsenite	0-8	tumor protein p53	Homo sapiens	65-68
22260869-0	2012	Arsenite-induced apoptosis of human neuroblastoma cells requires p53 but occurs independently of c-Jun.	arsenite	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	97-102
22260869-1	2012	Arsenite treatment of human SH-SY5Y neuroblastoma cells leads to an upregulation of caspase-3/7 activity and to the fragmentation of chromatin that is accompanied by elevated p53 and c-Jun levels.	arsenite	0-8	caspase 3	Homo sapiens	84-93
22260869-1	2012	Arsenite treatment of human SH-SY5Y neuroblastoma cells leads to an upregulation of caspase-3/7 activity and to the fragmentation of chromatin that is accompanied by elevated p53 and c-Jun levels.	arsenite	0-8	tumor protein p53	Homo sapiens	175-178
22260869-1	2012	Arsenite treatment of human SH-SY5Y neuroblastoma cells leads to an upregulation of caspase-3/7 activity and to the fragmentation of chromatin that is accompanied by elevated p53 and c-Jun levels.	arsenite	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	183-188
22260869-2	2012	Expression of a truncated mutant of p53, p53DD, which interfered with the oligomerization of p53, suppressed the arsenite-induced upregulation of caspase-3/7 activity and the fragmentation of chromatin, indicating that p53 is required for arsenite-induced cell death.	arsenite	113-121	tumor protein p53	Homo sapiens	36-39
22260869-2	2012	Expression of a truncated mutant of p53, p53DD, which interfered with the oligomerization of p53, suppressed the arsenite-induced upregulation of caspase-3/7 activity and the fragmentation of chromatin, indicating that p53 is required for arsenite-induced cell death.	arsenite	113-121	tumor protein p53	Homo sapiens	41-44
22260869-2	2012	Expression of a truncated mutant of p53, p53DD, which interfered with the oligomerization of p53, suppressed the arsenite-induced upregulation of caspase-3/7 activity and the fragmentation of chromatin, indicating that p53 is required for arsenite-induced cell death.	arsenite	113-121	caspase 3	Homo sapiens	146-155
22260869-2	2012	Expression of a truncated mutant of p53, p53DD, which interfered with the oligomerization of p53, suppressed the arsenite-induced upregulation of caspase-3/7 activity and the fragmentation of chromatin, indicating that p53 is required for arsenite-induced cell death.	arsenite	113-121	tumor protein p53	Homo sapiens	41-44
22260869-2	2012	Expression of a truncated mutant of p53, p53DD, which interfered with the oligomerization of p53, suppressed the arsenite-induced upregulation of caspase-3/7 activity and the fragmentation of chromatin, indicating that p53 is required for arsenite-induced cell death.	arsenite	239-247	tumor protein p53	Homo sapiens	36-39
22260869-2	2012	Expression of a truncated mutant of p53, p53DD, which interfered with the oligomerization of p53, suppressed the arsenite-induced upregulation of caspase-3/7 activity and the fragmentation of chromatin, indicating that p53 is required for arsenite-induced cell death.	arsenite	239-247	tumor protein p53	Homo sapiens	41-44
22260869-2	2012	Expression of a truncated mutant of p53, p53DD, which interfered with the oligomerization of p53, suppressed the arsenite-induced upregulation of caspase-3/7 activity and the fragmentation of chromatin, indicating that p53 is required for arsenite-induced cell death.	arsenite	239-247	caspase 3	Homo sapiens	146-155
22260869-2	2012	Expression of a truncated mutant of p53, p53DD, which interfered with the oligomerization of p53, suppressed the arsenite-induced upregulation of caspase-3/7 activity and the fragmentation of chromatin, indicating that p53 is required for arsenite-induced cell death.	arsenite	239-247	tumor protein p53	Homo sapiens	41-44
22260869-5	2012	Transcriptional upregulation of a chromatin-embedded p53-responsive reporter gene in either arsenite or nutlin-3 stimulated neuroblastoma cells revealed that the transcriptional activity of p53 was increased under these conditions.	arsenite	92-100	tumor protein p53	Homo sapiens	53-56
22260869-5	2012	Transcriptional upregulation of a chromatin-embedded p53-responsive reporter gene in either arsenite or nutlin-3 stimulated neuroblastoma cells revealed that the transcriptional activity of p53 was increased under these conditions.	arsenite	92-100	tumor protein p53	Homo sapiens	190-193
22260869-9	2012	Together, these data show that the upregulation of p53 is causally linked with arsenite-induced cell death in neuroblastoma cells, whereas the upregulation of c-Jun is not part of this apoptotic signaling cascade.	arsenite	79-87	tumor protein p53	Homo sapiens	51-54
22100391-0	2012	Phosphorylation of the M3/6 dual-specificity phosphatase enhances the activation of JNK by arsenite.	arsenite	91-99	mitogen-activated protein kinase 8	Homo sapiens	84-87
22100391-4	2012	It has been shown that M3/6 itself is phosphorylated by JNK upon stimulation with arsenite, but the role of this phosphorylation has not been investigated.	arsenite	82-90	mitogen-activated protein kinase 8	Homo sapiens	56-59
22100391-9	2012	Interestingly, expression of M3/6 phosphorylation mutants delayed the time-course of JNK phosphorylation and activation by arsenite.	arsenite	123-131	mitogen-activated protein kinase 8	Homo sapiens	85-88
22159698-0	2012	Inhibition of heme oxygenase-1 partially reverses the arsenite-mediated decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 catalytic activity in isolated rat hepatocytes.	arsenite	54-62	heme oxygenase 1	Rattus norvegicus	14-30
22159698-0	2012	Inhibition of heme oxygenase-1 partially reverses the arsenite-mediated decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 catalytic activity in isolated rat hepatocytes.	arsenite	54-62	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	84-90
22159698-0	2012	Inhibition of heme oxygenase-1 partially reverses the arsenite-mediated decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 catalytic activity in isolated rat hepatocytes.	arsenite	54-62	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	92-98
22159698-0	2012	Inhibition of heme oxygenase-1 partially reverses the arsenite-mediated decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 catalytic activity in isolated rat hepatocytes.	arsenite	54-62	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	100-107
22159698-0	2012	Inhibition of heme oxygenase-1 partially reverses the arsenite-mediated decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 catalytic activity in isolated rat hepatocytes.	arsenite	54-62	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	100-106
22159698-1	2012	Heme oxygenase (HO-1), the rate-limiting enzyme in the physiological breakdown of heme, is ubiquitous, and its expression can be increased by arsenite [As(III)], and similar other stimuli that induce cellular oxidative stress.	arsenite	142-150	heme oxygenase 1	Rattus norvegicus	16-20
22266315-0	2012	The Drosophila DUSP puckered is phosphorylated by JNK and p38 in response to arsenite-induced oxidative stress.	arsenite	77-85	basket	Drosophila melanogaster	50-53
22215663-5	2012	Our screen discovered several genes modulating arsenite-induced ER stress, including sodium-dependent neutral amino acid transporter, SNAT2.	arsenite	47-55	solute carrier family 38 member 2	Homo sapiens	134-139
22215663-6	2012	SNAT2 expression and activity are up-regulated by arsenite, in a manner dependent on activating transcription factor 4 (ATF4), an important mediator of the integrated stress response.	arsenite	50-58	solute carrier family 38 member 2	Homo sapiens	0-5
22215663-6	2012	SNAT2 expression and activity are up-regulated by arsenite, in a manner dependent on activating transcription factor 4 (ATF4), an important mediator of the integrated stress response.	arsenite	50-58	activating transcription factor 4	Homo sapiens	85-118
22215663-6	2012	SNAT2 expression and activity are up-regulated by arsenite, in a manner dependent on activating transcription factor 4 (ATF4), an important mediator of the integrated stress response.	arsenite	50-58	activating transcription factor 4	Homo sapiens	120-124
22266315-0	2012	The Drosophila DUSP puckered is phosphorylated by JNK and p38 in response to arsenite-induced oxidative stress.	arsenite	77-85	p38b MAP kinase	Drosophila melanogaster	58-61
22215663-7	2012	Inhibition of SNAT2 expression or activity or deprivation of its primary substrate, glutamine, specifically suppressed ER stress induced by arsenite but not tunicamycin.	arsenite	140-148	solute carrier family 38 member 2	Homo sapiens	14-19
22215663-8	2012	Induction of SNAT2 is coincident with the activation of the nutrient-sensing mammalian target of rapamycin (mTOR) pathway, which is at least partially required for arsenite-induced ER stress.	arsenite	164-172	solute carrier family 38 member 2	Homo sapiens	13-18
22215663-8	2012	Induction of SNAT2 is coincident with the activation of the nutrient-sensing mammalian target of rapamycin (mTOR) pathway, which is at least partially required for arsenite-induced ER stress.	arsenite	164-172	mechanistic target of rapamycin kinase	Homo sapiens	77-106
22266315-6	2012	In this study we show that Puckered is phosphorylated by JNK and p38 in response to arsenite-induced oxidative stress and that phosphorylation affects the interaction between Puckered and these MAPKs.	arsenite	84-92	basket	Drosophila melanogaster	57-60
22215663-8	2012	Induction of SNAT2 is coincident with the activation of the nutrient-sensing mammalian target of rapamycin (mTOR) pathway, which is at least partially required for arsenite-induced ER stress.	arsenite	164-172	mechanistic target of rapamycin kinase	Homo sapiens	108-112
22215663-9	2012	Importantly, inhibition of the SNAT2 or the System L transporter, LAT1, suppressed mTOR activation by arsenite, supporting a role for these transporters in modulating amino acid signaling.	arsenite	102-110	solute carrier family 38 member 2	Homo sapiens	31-36
22266315-6	2012	In this study we show that Puckered is phosphorylated by JNK and p38 in response to arsenite-induced oxidative stress and that phosphorylation affects the interaction between Puckered and these MAPKs.	arsenite	84-92	p38b MAP kinase	Drosophila melanogaster	65-68
22020379-4	2012	On the other hand, activities and protein expression of GS, GLAST and GLT-1 were significantly inhibited by arsenite exposure.	arsenite	108-116	solute carrier family 1 member 3	Homo sapiens	60-65
22215663-9	2012	Importantly, inhibition of the SNAT2 or the System L transporter, LAT1, suppressed mTOR activation by arsenite, supporting a role for these transporters in modulating amino acid signaling.	arsenite	102-110	solute carrier family 7 member 5	Homo sapiens	66-70
22215663-9	2012	Importantly, inhibition of the SNAT2 or the System L transporter, LAT1, suppressed mTOR activation by arsenite, supporting a role for these transporters in modulating amino acid signaling.	arsenite	102-110	mechanistic target of rapamycin kinase	Homo sapiens	83-87
22370793-6	2012	Arsenite, added concurrently with Con A or anti-CD3, significantly inhibited the production of interleukin-2 (IL-2), interferon-gamma (IFN-gamma), and interleukin-4 (IL-4) by splenocytes from young mice and significantly reduced the production of IL-10 by splenocytes from aged mice.	arsenite	0-8	interleukin 2	Mus musculus	95-108
22370793-6	2012	Arsenite, added concurrently with Con A or anti-CD3, significantly inhibited the production of interleukin-2 (IL-2), interferon-gamma (IFN-gamma), and interleukin-4 (IL-4) by splenocytes from young mice and significantly reduced the production of IL-10 by splenocytes from aged mice.	arsenite	0-8	interleukin 2	Mus musculus	110-114
22370793-6	2012	Arsenite, added concurrently with Con A or anti-CD3, significantly inhibited the production of interleukin-2 (IL-2), interferon-gamma (IFN-gamma), and interleukin-4 (IL-4) by splenocytes from young mice and significantly reduced the production of IL-10 by splenocytes from aged mice.	arsenite	0-8	interferon gamma	Mus musculus	117-133
22370793-6	2012	Arsenite, added concurrently with Con A or anti-CD3, significantly inhibited the production of interleukin-2 (IL-2), interferon-gamma (IFN-gamma), and interleukin-4 (IL-4) by splenocytes from young mice and significantly reduced the production of IL-10 by splenocytes from aged mice.	arsenite	0-8	interferon gamma	Mus musculus	135-144
22370793-6	2012	Arsenite, added concurrently with Con A or anti-CD3, significantly inhibited the production of interleukin-2 (IL-2), interferon-gamma (IFN-gamma), and interleukin-4 (IL-4) by splenocytes from young mice and significantly reduced the production of IL-10 by splenocytes from aged mice.	arsenite	0-8	interleukin 4	Mus musculus	151-164
22370793-6	2012	Arsenite, added concurrently with Con A or anti-CD3, significantly inhibited the production of interleukin-2 (IL-2), interferon-gamma (IFN-gamma), and interleukin-4 (IL-4) by splenocytes from young mice and significantly reduced the production of IL-10 by splenocytes from aged mice.	arsenite	0-8	interleukin 4	Mus musculus	166-170
22370793-6	2012	Arsenite, added concurrently with Con A or anti-CD3, significantly inhibited the production of interleukin-2 (IL-2), interferon-gamma (IFN-gamma), and interleukin-4 (IL-4) by splenocytes from young mice and significantly reduced the production of IL-10 by splenocytes from aged mice.	arsenite	0-8	interleukin 10	Mus musculus	247-252
22370793-7	2012	In contrast, the production of IL-2 and IL-4 by splenocytes from aged mice was only slightly affected by arsenite.	arsenite	105-113	interleukin 2	Mus musculus	31-35
22020379-4	2012	On the other hand, activities and protein expression of GS, GLAST and GLT-1 were significantly inhibited by arsenite exposure.	arsenite	108-116	solute carrier family 1 member 2	Homo sapiens	70-75
22020379-5	2012	Moreover, protein expression of GLAST and activities of GS were much more sensitive to arsenite.	arsenite	87-95	solute carrier family 1 member 3	Homo sapiens	32-37
22120617-0	2012	Low arsenite concentrations induce cell proliferation via activation of VEGF signaling in human neuroblastoma SH-SY5Y cells.	arsenite	4-12	vascular endothelial growth factor A	Homo sapiens	72-76
22130551-3	2012	To understand the role of aberrant expression of AQP in this disease, we over-expressed AQP3 and AQP9 in human melanoma WM266.4 cells and found that both AQPs significantly increased the chemoresistance of WM266.4 cells to arsenite.	arsenite	223-231	aquaporin 9	Homo sapiens	97-101
22130551-4	2012	Functional studies showed that AQP3 and AQP9 can inhibit cell apoptosis induced by arsenite through down-regulating p53 and up-regulating Bcl-2 and XIAP.	arsenite	83-91	aquaporin 3 (Gill blood group)	Homo sapiens	31-35
22130551-4	2012	Functional studies showed that AQP3 and AQP9 can inhibit cell apoptosis induced by arsenite through down-regulating p53 and up-regulating Bcl-2 and XIAP.	arsenite	83-91	aquaporin 9	Homo sapiens	40-44
22130551-4	2012	Functional studies showed that AQP3 and AQP9 can inhibit cell apoptosis induced by arsenite through down-regulating p53 and up-regulating Bcl-2 and XIAP.	arsenite	83-91	tumor protein p53	Homo sapiens	116-119
22130551-4	2012	Functional studies showed that AQP3 and AQP9 can inhibit cell apoptosis induced by arsenite through down-regulating p53 and up-regulating Bcl-2 and XIAP.	arsenite	83-91	BCL2 apoptosis regulator	Homo sapiens	138-143
22130551-4	2012	Functional studies showed that AQP3 and AQP9 can inhibit cell apoptosis induced by arsenite through down-regulating p53 and up-regulating Bcl-2 and XIAP.	arsenite	83-91	X-linked inhibitor of apoptosis	Homo sapiens	148-152
22130551-5	2012	Our data suggest the implication of APQ in melanoma progression and that the over-expression of AQP3 and AQP9 contributes to the chemoresistance of melanoma to arsenite.	arsenite	160-168	aquaporin 3 (Gill blood group)	Homo sapiens	96-100
22130551-5	2012	Our data suggest the implication of APQ in melanoma progression and that the over-expression of AQP3 and AQP9 contributes to the chemoresistance of melanoma to arsenite.	arsenite	160-168	aquaporin 9	Homo sapiens	105-109
22119299-3	2012	When grown on cadmium or arsenic (arsenite/arsenate), Dual-gene transgenic lines accumulated over 2-10 folds cadmium/arsenite and 2-3 folds arsenate than wild type or plants expressing AsPCS1 or YCF1 alone.	arsenite	34-42	hypothetical protein	Arabidopsis thaliana	195-199
22120617-5	2012	Inhibition of VEGF-induced signaling by SU4312, the inhibitor of VEGF receptor 2 kinase, and by treatment with anti-VEGF antibody blocked arsenite-induced increases in cell proliferation.	arsenite	138-146	vascular endothelial growth factor A	Homo sapiens	14-18
22120617-5	2012	Inhibition of VEGF-induced signaling by SU4312, the inhibitor of VEGF receptor 2 kinase, and by treatment with anti-VEGF antibody blocked arsenite-induced increases in cell proliferation.	arsenite	138-146	vascular endothelial growth factor A	Homo sapiens	65-69
22120617-5	2012	Inhibition of VEGF-induced signaling by SU4312, the inhibitor of VEGF receptor 2 kinase, and by treatment with anti-VEGF antibody blocked arsenite-induced increases in cell proliferation.	arsenite	138-146	vascular endothelial growth factor A	Homo sapiens	65-69
22120617-6	2012	Moreover, arsenite caused activation of ERK, a key signaling molecule involved in cell proliferation, and this activation was attenuated by SU4312, suggesting that ERK activation contributes to VEGF-mediated cell proliferation induced by arsenite.	arsenite	10-18	mitogen-activated protein kinase 1	Homo sapiens	40-43
22120617-6	2012	Moreover, arsenite caused activation of ERK, a key signaling molecule involved in cell proliferation, and this activation was attenuated by SU4312, suggesting that ERK activation contributes to VEGF-mediated cell proliferation induced by arsenite.	arsenite	10-18	mitogen-activated protein kinase 1	Homo sapiens	164-167
22120617-6	2012	Moreover, arsenite caused activation of ERK, a key signaling molecule involved in cell proliferation, and this activation was attenuated by SU4312, suggesting that ERK activation contributes to VEGF-mediated cell proliferation induced by arsenite.	arsenite	10-18	vascular endothelial growth factor A	Homo sapiens	194-198
22120617-6	2012	Moreover, arsenite caused activation of ERK, a key signaling molecule involved in cell proliferation, and this activation was attenuated by SU4312, suggesting that ERK activation contributes to VEGF-mediated cell proliferation induced by arsenite.	arsenite	238-246	mitogen-activated protein kinase 1	Homo sapiens	40-43
22120617-6	2012	Moreover, arsenite caused activation of ERK, a key signaling molecule involved in cell proliferation, and this activation was attenuated by SU4312, suggesting that ERK activation contributes to VEGF-mediated cell proliferation induced by arsenite.	arsenite	238-246	mitogen-activated protein kinase 1	Homo sapiens	164-167
22120617-6	2012	Moreover, arsenite caused activation of ERK, a key signaling molecule involved in cell proliferation, and this activation was attenuated by SU4312, suggesting that ERK activation contributes to VEGF-mediated cell proliferation induced by arsenite.	arsenite	238-246	vascular endothelial growth factor A	Homo sapiens	194-198
23285195-5	2012	Consistent with a functional ortholog, CNBP also associates with the poly(A) binding protein and accumulates in stress granules during arsenite treatment of human cells.	arsenite	135-143	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	39-43
21391215-6	2012	This implied that the effect of arsenite on progesterone production may require cAMP/PKA and ERK1/2 signaling but not depend on them.	arsenite	32-40	mitogen activated protein kinase 3	Rattus norvegicus	93-99
21391215-9	2012	Arsenite treatment induced caspase-3 activation, although no apoptosis was observed.	arsenite	0-8	caspase 3	Rattus norvegicus	27-36
21391215-10	2012	Inhibition of caspase-3 activity significantly decreased progesterone production stimulated by arsenite or follicle-stimulating hormone (FSH).	arsenite	95-103	caspase 3	Rattus norvegicus	14-23
21391215-12	2012	Collectively, this study demonstrated for the first time that arsenite stimulates progesterone production through cleaved/active caspase-3-dependent pathway, and the increase of GSH level promoted by progesterone production may protect GCs against apoptosis and maintain the steroidogenesis of GCs in response to arsenite treatment.	arsenite	62-70	caspase 3	Rattus norvegicus	129-138
21344382-4	2011	To further characterize the role of oxidative stress in arsenite-induced cell transformation via the reactive oxygen species (ROS)-mediated Ras/Erk pathway, here we demonstrated arsenite-induced rat lung epithelial cell (LEC) transformation, epithelial-mesenchymal transition, stimulation of the extracellular signal-regulated kinase signaling pathway, and enhancement of cell proliferation.	arsenite	56-64	Eph receptor B1	Rattus norvegicus	144-147
22662215-0	2012	EMT and stem cell-like properties associated with HIF-2alpha are involved in arsenite-induced transformation of human bronchial epithelial cells.	arsenite	77-85	endothelial PAS domain protein 1	Homo sapiens	50-60
22662215-8	2012	Twist1 and Bmi1 are involved in arsenite-induced EMT.	arsenite	32-40	twist family bHLH transcription factor 1	Homo sapiens	0-6
22662215-8	2012	Twist1 and Bmi1 are involved in arsenite-induced EMT.	arsenite	32-40	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	11-15
22662215-10	2012	The self-renewal genes, Oct4, Bmi1, and ALDH1, are necessary for arsenite-mediated maintenance of stem cells.	arsenite	65-73	POU class 5 homeobox 1	Homo sapiens	24-28
22662215-10	2012	The self-renewal genes, Oct4, Bmi1, and ALDH1, are necessary for arsenite-mediated maintenance of stem cells.	arsenite	65-73	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	30-34
22662215-10	2012	The self-renewal genes, Oct4, Bmi1, and ALDH1, are necessary for arsenite-mediated maintenance of stem cells.	arsenite	65-73	aldehyde dehydrogenase 1 family member A1	Homo sapiens	40-45
22662215-11	2012	CONCLUSIONS: EMT, regulated by HIF-2alpha, and the development of a cancer stem cell-like phenotype are associated with arsenite-induced transformation of HBE cells.	arsenite	120-128	endothelial PAS domain protein 1	Homo sapiens	31-41
21465251-0	2011	Rat H9c2 cardiac myocytes are sensitive to arsenite due to a modest activation of transcription factor Nrf2.	arsenite	43-51	NFE2 like bZIP transcription factor 2	Rattus norvegicus	103-107
21933836-8	2011	In further studies, we show that arsenite-induced oxidative stress caused relocalization of PQBP1 to stress granules (SGs), where PQBP1 co-localizes with the new binding partners as well as with FMRP.	arsenite	33-41	polyglutamine binding protein 1	Homo sapiens	92-97
21933836-8	2011	In further studies, we show that arsenite-induced oxidative stress caused relocalization of PQBP1 to stress granules (SGs), where PQBP1 co-localizes with the new binding partners as well as with FMRP.	arsenite	33-41	polyglutamine binding protein 1	Homo sapiens	130-135
21933836-8	2011	In further studies, we show that arsenite-induced oxidative stress caused relocalization of PQBP1 to stress granules (SGs), where PQBP1 co-localizes with the new binding partners as well as with FMRP.	arsenite	33-41	fragile X messenger ribonucleoprotein 1	Homo sapiens	195-199
21344382-4	2011	To further characterize the role of oxidative stress in arsenite-induced cell transformation via the reactive oxygen species (ROS)-mediated Ras/Erk pathway, here we demonstrated arsenite-induced rat lung epithelial cell (LEC) transformation, epithelial-mesenchymal transition, stimulation of the extracellular signal-regulated kinase signaling pathway, and enhancement of cell proliferation.	arsenite	178-186	Eph receptor B1	Rattus norvegicus	144-147
21344382-6	2011	Since ROS is involved in arsenite-induced LEC cell transformation, Redox-status regulatory proteins (Cu/Zn SOD and thioredoxin) and arsenite-induced LEC cell transformation were significantly inhibited by concurrent treatment with the antioxidants.	arsenite	25-33	superoxide dismutase 1	Rattus norvegicus	101-110
21344382-6	2011	Since ROS is involved in arsenite-induced LEC cell transformation, Redox-status regulatory proteins (Cu/Zn SOD and thioredoxin) and arsenite-induced LEC cell transformation were significantly inhibited by concurrent treatment with the antioxidants.	arsenite	25-33	thioredoxin 1	Rattus norvegicus	115-126
21344382-7	2011	Our experimental results clearly demonstrated that induction of p-ERK and cell proliferation by arsenite is mediated via oxidative stress, since antioxidants can inhibit arsenite-induced cell transformation.	arsenite	96-104	Eph receptor B1	Rattus norvegicus	66-69
21813702-0	2011	Junin virus infection impairs stress-granule formation in Vero cells treated with arsenite via inhibition of eIF2alpha phosphorylation.	arsenite	82-90	eukaryotic translation initiation factor 2A	Chlorocebus sabaeus	109-118
22135363-4	2011	In arsenite-stressed cells, endogenous mRNAs aggregated in granules that colocalized with SGs marked by TIA-1-GFP.	arsenite	3-11	TIA1 cytotoxic granule associated RNA binding protein	Homo sapiens	104-109
21813702-6	2011	Expression of N and GPC also impaired eIF2alpha phosphorylation triggered by arsenite.	arsenite	77-85	eukaryotic translation initiation factor 2A	Chlorocebus sabaeus	38-47
23724280-6	2011	The expressions of arsenic-sensitive stress gene metallothionein-1 were increased 3-7-folds after arsenite or arsenate, but were unaltered after NHJD and realgar.	arsenite	98-106	metallothionein 1	Mus musculus	49-66
21688155-0	2011	IKKbeta downregulation is critical for triggering JNKs-dependent cell apoptotic response in the human hepatoma cells under arsenite exposure.	arsenite	123-131	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	0-7
21688155-4	2011	We found that arsenite exposure induced JNKs and AP-1 activation accompanying with a significant reduction of both IKKalpha and IKKbeta expressions.	arsenite	14-22	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	115-123
21688155-4	2011	We found that arsenite exposure induced JNKs and AP-1 activation accompanying with a significant reduction of both IKKalpha and IKKbeta expressions.	arsenite	14-22	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	128-135
21688155-5	2011	Overexpression of IKKbeta, but not of IKKalpha, inhibited arsenite-induced MKK7/JNKs/AP-1 pathway activation as well as the apoptotic response.	arsenite	58-66	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	18-25
21688155-5	2011	Overexpression of IKKbeta, but not of IKKalpha, inhibited arsenite-induced MKK7/JNKs/AP-1 pathway activation as well as the apoptotic response.	arsenite	58-66	mitogen-activated protein kinase kinase 7	Homo sapiens	75-79
21688155-6	2011	Therefore,  we conclude that the downregulation of IKKbeta expression is the prerequisite signaling event for mediating JNKs pathway activation and the cellular apoptotic response in the HepG2 cells under arsenite exposure.	arsenite	205-213	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	51-58
21688155-7	2011	Targeting IKKbeta might be helpful to enhance the tumor therapeutic effect of arsenite.	arsenite	78-86	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	10-17
22098917-2	2011	The goal of the present study was to determine if ENO2 expression in the breast epithelial cell is influenced by the environmental pollutants, arsenite and cadmium.	arsenite	143-151	enolase 2	Homo sapiens	50-54
21934131-0	2011	Mouse arsenic (+3 oxidation state) methyltransferase genotype affects metabolism and tissue dosimetry of arsenicals after arsenite administration in drinking water.	arsenite	122-130	arsenite methyltransferase	Mus musculus	6-52
21971544-0	2011	Arsenite induces cell transformation by reactive oxygen species, AKT, ERK1/2, and p70S6K1.	arsenite	0-8	AKT serine/threonine kinase 1	Homo sapiens	65-68
21971544-0	2011	Arsenite induces cell transformation by reactive oxygen species, AKT, ERK1/2, and p70S6K1.	arsenite	0-8	mitogen-activated protein kinase 3	Homo sapiens	70-76
20196163-4	2011	The 2,4-dinitrophenylhydrazine (DNPH) dot-blot assay revealed that arsenite (0-50 muM) dose-dependently increased protein carbonylation.	arsenite	67-75	latexin	Homo sapiens	82-85
21726611-0	2011	Up-regulation of cyclin D1 by JNK1/c-Jun is involved in tumorigenesis of human embryo lung fibroblast cells induced by a low concentration of arsenite.	arsenite	142-150	cyclin D1	Homo sapiens	17-26
21726611-0	2011	Up-regulation of cyclin D1 by JNK1/c-Jun is involved in tumorigenesis of human embryo lung fibroblast cells induced by a low concentration of arsenite.	arsenite	142-150	mitogen-activated protein kinase 8	Homo sapiens	30-34
21726611-0	2011	Up-regulation of cyclin D1 by JNK1/c-Jun is involved in tumorigenesis of human embryo lung fibroblast cells induced by a low concentration of arsenite.	arsenite	142-150	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	35-40
21726611-6	2011	Moreover, arsenite activates the JNK1/c-Jun signal pathway, but not JNK2, which up-regulates the expression of cyclin D1/CDK4 and phosphorylates the retinoblastoma (Rb) protein.	arsenite	10-18	mitogen-activated protein kinase 8	Homo sapiens	33-37
21726611-6	2011	Moreover, arsenite activates the JNK1/c-Jun signal pathway, but not JNK2, which up-regulates the expression of cyclin D1/CDK4 and phosphorylates the retinoblastoma (Rb) protein.	arsenite	10-18	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	38-43
21726611-6	2011	Moreover, arsenite activates the JNK1/c-Jun signal pathway, but not JNK2, which up-regulates the expression of cyclin D1/CDK4 and phosphorylates the retinoblastoma (Rb) protein.	arsenite	10-18	cyclin D1	Homo sapiens	111-120
21726611-6	2011	Moreover, arsenite activates the JNK1/c-Jun signal pathway, but not JNK2, which up-regulates the expression of cyclin D1/CDK4 and phosphorylates the retinoblastoma (Rb) protein.	arsenite	10-18	cyclin dependent kinase 4	Homo sapiens	121-125
21726611-6	2011	Moreover, arsenite activates the JNK1/c-Jun signal pathway, but not JNK2, which up-regulates the expression of cyclin D1/CDK4 and phosphorylates the retinoblastoma (Rb) protein.	arsenite	10-18	RB transcriptional corepressor 1	Homo sapiens	149-163
21726611-6	2011	Moreover, arsenite activates the JNK1/c-Jun signal pathway, but not JNK2, which up-regulates the expression of cyclin D1/CDK4 and phosphorylates the retinoblastoma (Rb) protein.	arsenite	10-18	RB transcriptional corepressor 1	Homo sapiens	165-167
21726611-7	2011	Blocking of the JNK1/c-Jun signal pathway suppresses the increases of cyclin D1 expression and Rb phosphorylation, which attenuates cell proliferation, reduces the transition from the G1 to the S phase, and thereby inhibits the neoplastic transformation of HELF cells induced by a low concentration of arsenite.	arsenite	302-310	mitogen-activated protein kinase 8	Homo sapiens	16-20
21726611-7	2011	Blocking of the JNK1/c-Jun signal pathway suppresses the increases of cyclin D1 expression and Rb phosphorylation, which attenuates cell proliferation, reduces the transition from the G1 to the S phase, and thereby inhibits the neoplastic transformation of HELF cells induced by a low concentration of arsenite.	arsenite	302-310	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	21-26
21726611-7	2011	Blocking of the JNK1/c-Jun signal pathway suppresses the increases of cyclin D1 expression and Rb phosphorylation, which attenuates cell proliferation, reduces the transition from the G1 to the S phase, and thereby inhibits the neoplastic transformation of HELF cells induced by a low concentration of arsenite.	arsenite	302-310	cyclin D1	Homo sapiens	70-79
21726611-7	2011	Blocking of the JNK1/c-Jun signal pathway suppresses the increases of cyclin D1 expression and Rb phosphorylation, which attenuates cell proliferation, reduces the transition from the G1 to the S phase, and thereby inhibits the neoplastic transformation of HELF cells induced by a low concentration of arsenite.	arsenite	302-310	RB transcriptional corepressor 1	Homo sapiens	95-97
21726611-8	2011	Thus, activation of the JNK1/c-Jun pathway up-regulates the expression of cyclin D1, which is involved in the tumorigenesis caused by a low concentration of arsenite.	arsenite	157-165	mitogen-activated protein kinase 8	Homo sapiens	24-28
21726611-8	2011	Thus, activation of the JNK1/c-Jun pathway up-regulates the expression of cyclin D1, which is involved in the tumorigenesis caused by a low concentration of arsenite.	arsenite	157-165	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	29-34
21726611-8	2011	Thus, activation of the JNK1/c-Jun pathway up-regulates the expression of cyclin D1, which is involved in the tumorigenesis caused by a low concentration of arsenite.	arsenite	157-165	cyclin D1	Homo sapiens	74-83
23175888-9	2011	The serum ALT, AST and GGT activities +/- SEM were 67.04 + 3.71, 39.12 +/- 3.45 and 11.54 +/- 0.42 lu respectively for the rats treated with arsenite alone.	arsenite	141-149	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	15-18
23175888-9	2011	The serum ALT, AST and GGT activities +/- SEM were 67.04 + 3.71, 39.12 +/- 3.45 and 11.54 +/- 0.42 lu respectively for the rats treated with arsenite alone.	arsenite	141-149	gamma-glutamyltransferase 1	Rattus norvegicus	23-26
23175888-10	2011	Combined treatment of arsenite and the extract significantly decrease (p<0.05) in the activity of the enzymes, 29.75 +/- 3.43, 15.8 +/- 4.42, 6.87 +/- 0.433 lu for serum ALT, AST and GGT respectively.	arsenite	22-30	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	178-181
23175888-10	2011	Combined treatment of arsenite and the extract significantly decrease (p<0.05) in the activity of the enzymes, 29.75 +/- 3.43, 15.8 +/- 4.42, 6.87 +/- 0.433 lu for serum ALT, AST and GGT respectively.	arsenite	22-30	gamma-glutamyltransferase 1	Rattus norvegicus	186-189
21370284-7	2011	Our results demonstrated that the viability of Pol beta-deficient mouse embryonic fibroblasts was much lower than that of Pol beta wild-type cells after treatment with arsenite (As(3+) ).	arsenite	168-176	polymerase (DNA directed), beta	Mus musculus	47-55
21586431-8	2011	The results reveal that the residue at the H5 position of the ar/R filter of both OsLsi1 and AtNIP5;1 plays a key role in the permeability to Si and B, but there is a relatively low selectivity for arsenite.	arsenite	198-206	NOD26-like intrinsic protein 5;1	Arabidopsis thaliana	93-101
21447319-4	2011	In this work, we show that arsenite and antimonite uptake into everted membrane vesicles via the yeast Acr3 transporter is coupled to the electrochemical potential gradient of protons generated by the plasma membrane H(+)-translocating P-type ATPase.	arsenite	27-35	Arr3p	Saccharomyces cerevisiae S288C	103-107
21447319-6	2011	Two differential kinetic assays revealed that Acr3p-mediated arsenite/H(+) and antimonite/H(+) exchange demonstrates Michaelis-Menten-type saturation kinetics characterized by a maximum flux for permeating metalloids.	arsenite	61-69	Arr3p	Saccharomyces cerevisiae S288C	46-51
21447319-7	2011	The approximate K(m) values for arsenite and antimonite transport were the same, suggesting that Acr3p exhibits similar low affinity for both metalloids.	arsenite	32-40	Arr3p	Saccharomyces cerevisiae S288C	97-102
21447319-9	2011	These findings may explain a predominant role of Acr3p in conferring arsenite tolerance in S. cerevisiae.	arsenite	69-77	Arr3p	Saccharomyces cerevisiae S288C	49-54
21782832-6	2011	For the first time gene expression, protein level and in case of human 8-oxoguanine DNA glycosylase 1 (hOGG1) protein function was examined in one study, comparing inorganic arsenite and its trivalent and pentavalent mono- and dimethylated metabolites, also taking into account their cellular bioavailability.	arsenite	174-182	8-oxoguanine DNA glycosylase	Homo sapiens	103-108
21757713-0	2011	Phosphorylation of Raptor by p38beta participates in arsenite-induced mammalian target of rapamycin complex 1 (mTORC1) activation.	arsenite	53-61	regulatory associated protein of MTOR complex 1	Homo sapiens	19-25
21757713-0	2011	Phosphorylation of Raptor by p38beta participates in arsenite-induced mammalian target of rapamycin complex 1 (mTORC1) activation.	arsenite	53-61	mitogen-activated protein kinase 11	Homo sapiens	29-36
21757713-0	2011	Phosphorylation of Raptor by p38beta participates in arsenite-induced mammalian target of rapamycin complex 1 (mTORC1) activation.	arsenite	53-61	mechanistic target of rapamycin kinase	Homo sapiens	70-99
21757713-0	2011	Phosphorylation of Raptor by p38beta participates in arsenite-induced mammalian target of rapamycin complex 1 (mTORC1) activation.	arsenite	53-61	CREB regulated transcription coactivator 1	Mus musculus	111-117
21757713-6	2011	Here we show the activation of p38beta participates in activation of mTOR complex 1 (mTORC1) induced by arsenite but not insulin, nutrients, anisomycin, or H(2)O(2).	arsenite	104-112	mitogen-activated protein kinase 11	Homo sapiens	31-38
21757713-6	2011	Here we show the activation of p38beta participates in activation of mTOR complex 1 (mTORC1) induced by arsenite but not insulin, nutrients, anisomycin, or H(2)O(2).	arsenite	104-112	mechanistic target of rapamycin kinase	Homo sapiens	69-73
21757713-6	2011	Here we show the activation of p38beta participates in activation of mTOR complex 1 (mTORC1) induced by arsenite but not insulin, nutrients, anisomycin, or H(2)O(2).	arsenite	104-112	CREB regulated transcription coactivator 1	Mus musculus	85-91
21757713-7	2011	Arsenite treatment of cells activates p38beta and induces interaction between p38beta and Raptor, a regulatory component of mTORC1, resulting in phosphorylation of Raptor on Ser(863) and Ser(771).	arsenite	0-8	mitogen-activated protein kinase 11	Homo sapiens	38-45
21757713-7	2011	Arsenite treatment of cells activates p38beta and induces interaction between p38beta and Raptor, a regulatory component of mTORC1, resulting in phosphorylation of Raptor on Ser(863) and Ser(771).	arsenite	0-8	mitogen-activated protein kinase 11	Homo sapiens	78-85
21757713-7	2011	Arsenite treatment of cells activates p38beta and induces interaction between p38beta and Raptor, a regulatory component of mTORC1, resulting in phosphorylation of Raptor on Ser(863) and Ser(771).	arsenite	0-8	regulatory associated protein of MTOR complex 1	Homo sapiens	90-96
21757713-7	2011	Arsenite treatment of cells activates p38beta and induces interaction between p38beta and Raptor, a regulatory component of mTORC1, resulting in phosphorylation of Raptor on Ser(863) and Ser(771).	arsenite	0-8	CREB regulated transcription coactivator 1	Mus musculus	124-130
21757713-7	2011	Arsenite treatment of cells activates p38beta and induces interaction between p38beta and Raptor, a regulatory component of mTORC1, resulting in phosphorylation of Raptor on Ser(863) and Ser(771).	arsenite	0-8	regulatory associated protein of MTOR complex 1	Homo sapiens	164-170
21757713-8	2011	The phosphorylation of Raptor on these sites enhances mTORC1 activity, and contributes largely to arsenite-induced mTORC1 activation.	arsenite	98-106	regulatory associated protein of MTOR complex 1	Homo sapiens	23-29
21757713-8	2011	The phosphorylation of Raptor on these sites enhances mTORC1 activity, and contributes largely to arsenite-induced mTORC1 activation.	arsenite	98-106	CREB regulated transcription coactivator 1	Mus musculus	115-121
21596116-2	2011	Using RNA interference technique, we investigated the possible mechanism involved in GAL1 modulation of arsenite-inhibited cell survival in 3T3 fibroblast and KB oral cancer cells.	arsenite	104-112	lectin, galactose binding, soluble 1	Mus musculus	85-89
21550982-3	2011	Here, we report that arsenite binds to both CCHC DNA-binding zinc fingers of the DNA repair protein PARP-1 (poly(ADP-ribose) polymerase-1).	arsenite	21-29	poly(ADP-ribose) polymerase 1	Homo sapiens	100-106
21550982-3	2011	Here, we report that arsenite binds to both CCHC DNA-binding zinc fingers of the DNA repair protein PARP-1 (poly(ADP-ribose) polymerase-1).	arsenite	21-29	poly(ADP-ribose) polymerase 1	Homo sapiens	108-137
21550982-5	2011	MALDI-TOF-MS analysis of peptides harboring site-directed substitutions of cysteine with histidine residues within the PARP-1 zinc finger revealed that arsenite bound to peptides containing three or four cysteine residues, but not to peptides with two cysteines, demonstrating arsenite binding selectivity.	arsenite	152-160	poly(ADP-ribose) polymerase 1	Homo sapiens	119-125
21550982-6	2011	This finding was not unique to PARP-1; arsenite did not bind to a peptide representing the CCHH zinc finger of the DNA repair protein aprataxin, but did bind to an aprataxin peptide mutated to a CCHC zinc finger.	arsenite	39-47	aprataxin	Homo sapiens	164-173
21550982-7	2011	To investigate the impact of arsenite on PARP-1 zinc finger function, we measured the zinc content and DNA-binding capacity of PARP-1 immunoprecipitated from arsenite-exposed cells.	arsenite	158-166	poly(ADP-ribose) polymerase 1	Homo sapiens	127-133
21550982-10	2011	These findings demonstrate that PARP-1 is a direct molecular target of arsenite and that arsenite interacts selectively with zinc finger motifs containing three or more cysteine residues.	arsenite	71-79	poly(ADP-ribose) polymerase 1	Homo sapiens	32-38
21550982-10	2011	These findings demonstrate that PARP-1 is a direct molecular target of arsenite and that arsenite interacts selectively with zinc finger motifs containing three or more cysteine residues.	arsenite	89-97	poly(ADP-ribose) polymerase 1	Homo sapiens	32-38
21370284-8	2011	An increased level of DNA damage and significantly delayed arsenite-induced DNA damage repair in Pol beta-deficient cells indicated reduced repair of DNA lesions under Pol beta deficiency.	arsenite	59-67	DNA polymerase beta	Homo sapiens	97-105
21370284-9	2011	This was consistent with the increase in the frequency of micronuclei (MN), an indicator of chromosomal breakage, which was also observed in Pol beta-deficient cells treated with arsenite.	arsenite	179-187	DNA polymerase beta	Homo sapiens	141-149
21370284-11	2011	In conclusion, our results indicate an important role for Pol beta in repairing arsenite-induced DNA damage and maintaining chromosomal integrity and further suggest deficiency of BER may be involved in arsenic genotoxicity and carcinogenicity.	arsenite	80-88	DNA polymerase beta	Homo sapiens	58-66
21624607-0	2011	Kindlin-2 expression in arsenite- and cadmium-transformed bladder cancer cell lines and in archival specimens of human bladder cancer.	arsenite	24-32	FERM domain containing kindlin 2	Homo sapiens	0-9
21537954-11	2011	These findings indicated that AS3MT expression enhanced the cytotoxic effect of arsenite in tet(+) cells because these cells accumulated more arsenic metabolites than did the tet(-) cells, and accordingly, the tet(+) cells were more susceptible to arsenic than were the tet(-) cells.	arsenite	80-88	arsenite methyltransferase	Homo sapiens	30-35
21385732-2	2011	In a previous study, female As3mt knockout (KO) mice treated with diet containing 100 or 150 ppm arsenic as arsenite showed systemic toxicity and significant effects on the urothelium.	arsenite	108-116	arsenite methyltransferase	Mus musculus	28-33
21385732-9	2011	The present study shows a dose-response for the effects of orally administered arsenite on the bladder urothelium of wild-type and As3mt KO mice, with greater effects in the KO strain but with a no effect level of 1 ppm for both.	arsenite	79-87	arsenite methyltransferase	Mus musculus	131-136
21268130-4	2011	The phosphorylation of AKT and its downstream targets, 70-kDa ribosomal protein S6 kinase (p70S6K) and translation initiation factor 4B (eIF4B), are increased in the arsenite treated cells, indicating that long-term arsenite treatment activates AKT-p70S6K signaling pathway.	arsenite	166-174	AKT serine/threonine kinase 1	Homo sapiens	23-26
21268130-4	2011	The phosphorylation of AKT and its downstream targets, 70-kDa ribosomal protein S6 kinase (p70S6K) and translation initiation factor 4B (eIF4B), are increased in the arsenite treated cells, indicating that long-term arsenite treatment activates AKT-p70S6K signaling pathway.	arsenite	166-174	ribosomal protein S6 kinase B1	Homo sapiens	91-97
21268130-4	2011	The phosphorylation of AKT and its downstream targets, 70-kDa ribosomal protein S6 kinase (p70S6K) and translation initiation factor 4B (eIF4B), are increased in the arsenite treated cells, indicating that long-term arsenite treatment activates AKT-p70S6K signaling pathway.	arsenite	166-174	eukaryotic translation initiation factor 4B	Homo sapiens	137-142
21268130-4	2011	The phosphorylation of AKT and its downstream targets, 70-kDa ribosomal protein S6 kinase (p70S6K) and translation initiation factor 4B (eIF4B), are increased in the arsenite treated cells, indicating that long-term arsenite treatment activates AKT-p70S6K signaling pathway.	arsenite	166-174	AKT serine/threonine kinase 1	Homo sapiens	245-248
21268130-4	2011	The phosphorylation of AKT and its downstream targets, 70-kDa ribosomal protein S6 kinase (p70S6K) and translation initiation factor 4B (eIF4B), are increased in the arsenite treated cells, indicating that long-term arsenite treatment activates AKT-p70S6K signaling pathway.	arsenite	166-174	ribosomal protein S6 kinase B1	Homo sapiens	249-255
21268130-4	2011	The phosphorylation of AKT and its downstream targets, 70-kDa ribosomal protein S6 kinase (p70S6K) and translation initiation factor 4B (eIF4B), are increased in the arsenite treated cells, indicating that long-term arsenite treatment activates AKT-p70S6K signaling pathway.	arsenite	216-224	AKT serine/threonine kinase 1	Homo sapiens	23-26
21268130-4	2011	The phosphorylation of AKT and its downstream targets, 70-kDa ribosomal protein S6 kinase (p70S6K) and translation initiation factor 4B (eIF4B), are increased in the arsenite treated cells, indicating that long-term arsenite treatment activates AKT-p70S6K signaling pathway.	arsenite	216-224	ribosomal protein S6 kinase B1	Homo sapiens	91-97
21268130-5	2011	In addition, long-term exposure to arsenite up-regulates eIF4B expression and increases the rate of translation.	arsenite	35-43	eukaryotic translation initiation factor 4B	Homo sapiens	57-62
21268130-7	2011	Moreover, the expression of c-Myc which is up-regulated by long-term arsenite treatment is inhibited by eIF4B knockdown.	arsenite	69-77	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	28-33
21268130-7	2011	Moreover, the expression of c-Myc which is up-regulated by long-term arsenite treatment is inhibited by eIF4B knockdown.	arsenite	69-77	eukaryotic translation initiation factor 4B	Homo sapiens	104-109
21439358-6	2011	Arsenite leads to an increase in intracellular Ca levels and generation of reactive oxygen species, which may cause a decrease in mitochondrial transmembrane potential, release of cytochrome c, and consequent activation of caspases.	arsenite	0-8	cytochrome c, somatic	Homo sapiens	180-192
21624607-3	2011	METHODS: A combination of real-time polymerase chain reaction, Western analysis, and immunohistochemistry was used to characterize Kindlin-2 expression in arsenite (As(+3))- and cadmium (Cd(+2))-transformed human cell lines, their tumor transplants in immunocompromised mice, and in archival specimens of human bladder and bladder cancer.	arsenite	155-163	FERM domain containing kindlin 2	Homo sapiens	131-140
21266531-7	2011	Arsenite-induced ABCB6 expression was transcriptionally regulated, but this induction was not mediated by the redox-sensitive transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2).	arsenite	0-8	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	17-22
21292642-4	2011	We found that prolonged exposure of immortalized p53-knocked down human bronchial epithelial cells (p53(low)HBECs) to low levels of arsenite (NaAsO2, 2.5 muM) caused malignant transformation that was accompanied by epithelial to mesenchymal transition (EMT) and reduction in the levels of miR-200 family members.	arsenite	132-140	tumor protein p53	Homo sapiens	49-52
21292642-4	2011	We found that prolonged exposure of immortalized p53-knocked down human bronchial epithelial cells (p53(low)HBECs) to low levels of arsenite (NaAsO2, 2.5 muM) caused malignant transformation that was accompanied by epithelial to mesenchymal transition (EMT) and reduction in the levels of miR-200 family members.	arsenite	132-140	tumor protein p53	Homo sapiens	100-103
21292642-5	2011	Stably reexpressing miR-200b in arsenite-transformed cells (As-p53(low)HBECs) completely reversed their transformed phenotypes, as evidenced by inhibition of colony formation in soft agar and prevention of xenograft tumor formation in nude mice.	arsenite	32-40	microRNA 200b	Mus musculus	20-28
21292642-5	2011	Stably reexpressing miR-200b in arsenite-transformed cells (As-p53(low)HBECs) completely reversed their transformed phenotypes, as evidenced by inhibition of colony formation in soft agar and prevention of xenograft tumor formation in nude mice.	arsenite	32-40	transformation related protein 53, pseudogene	Mus musculus	63-66
21292642-6	2011	Moreover, stably expressing miR-200b alone in parental nontransformed p53(low)HBECs was sufficient to completely prevent arsenite exposure from inducing EMT and malignant transformation.	arsenite	121-129	microRNA 200b	Homo sapiens	28-36
21292642-6	2011	Moreover, stably expressing miR-200b alone in parental nontransformed p53(low)HBECs was sufficient to completely prevent arsenite exposure from inducing EMT and malignant transformation.	arsenite	121-129	tumor protein p53	Homo sapiens	70-73
21292642-8	2011	Stably expressing ZEB1 alone in parental nontransformed p53(low)HBECs was sufficient to deplete miR-200, induce EMT and cause cell transformation, phenocopying the oncogenic effect of 16-week arsenite exposure.	arsenite	192-200	zinc finger E-box binding homeobox 1	Homo sapiens	18-22
21396911-0	2011	Prolonged inorganic arsenite exposure suppresses insulin-stimulated AKT S473 phosphorylation and glucose uptake in 3T3-L1 adipocytes: involvement of the adaptive antioxidant response.	arsenite	20-28	insulin	Homo sapiens	49-56
21396911-0	2011	Prolonged inorganic arsenite exposure suppresses insulin-stimulated AKT S473 phosphorylation and glucose uptake in 3T3-L1 adipocytes: involvement of the adaptive antioxidant response.	arsenite	20-28	AKT serine/threonine kinase 1	Homo sapiens	68-71
21266531-8	2011	We demonstrate that, in HepG2 and Hep3B cells, knockdown of ABCB6 expression using ABCB6-specific small interfering RNA sensitized the cells to arsenite toxicity.	arsenite	144-152	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	60-65
21266531-8	2011	We demonstrate that, in HepG2 and Hep3B cells, knockdown of ABCB6 expression using ABCB6-specific small interfering RNA sensitized the cells to arsenite toxicity.	arsenite	144-152	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	83-88
21266531-9	2011	In contrast, stable overexpression of ABCB6 conferred a strong survival advantage toward arsenite-induced oxidative stress.	arsenite	89-97	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	38-43
21266531-10	2011	Collectively, these results, obtained by both loss of function and gain of function analysis, suggest that ABCB6 expression in response to sodium arsenite might be an endogenous protective mechanism activated to protect cells against arsenite-induced oxidative stress.	arsenite	146-154	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	107-112
21167264-0	2011	Effects of DNMT and MEK inhibitors on the expression of RECK, MMP-9, -2, uPA and VEGF in response to arsenite stimulation in human uroepithelial cells.	arsenite	101-109	DNA methyltransferase 1	Homo sapiens	11-15
21129479-6	2011	RESULTS: Arsenite and arsenate increased serum alanine aminotransferase (ALT) levels, indicative of liver injury; blood urea nitrogen (BUN) was also increased by arsenite and arsenate, indicative of nephrotoxicity.	arsenite	9-17	glutamic pyruvic transaminase, soluble	Mus musculus	47-71
21129479-6	2011	RESULTS: Arsenite and arsenate increased serum alanine aminotransferase (ALT) levels, indicative of liver injury; blood urea nitrogen (BUN) was also increased by arsenite and arsenate, indicative of nephrotoxicity.	arsenite	9-17	glutamic pyruvic transaminase, soluble	Mus musculus	73-76
21129479-10	2011	The expressions of arsenic-sensitive stress genes, namely metallothionein-1 and heme oxygenase-1, were increased after arsenite or arsenate by 3-10-folds, but were unaltered after LWS and realgar.	arsenite	119-127	metallothionein 1	Mus musculus	58-75
21129479-10	2011	The expressions of arsenic-sensitive stress genes, namely metallothionein-1 and heme oxygenase-1, were increased after arsenite or arsenate by 3-10-folds, but were unaltered after LWS and realgar.	arsenite	119-127	heme oxygenase 1	Mus musculus	80-96
21167264-9	2011	Our results show that arsenite downregulation of RECK is caused by epigenetic inactivation via promoter hypermethylation, and that levels of MMP-9, -2, uPA and VEGF were increased in human uroepithelial cells (SV-HUC-1).	arsenite	22-30	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	49-53
21167264-10	2011	However, when the cells were pretreated with inhibitors (5-aza-CdR or U0126) for 24h, the effects of arsenite on RECK, MMP-9, -2, uPA and VEGF expression were suppressed.	arsenite	101-109	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	113-117
21167264-10	2011	However, when the cells were pretreated with inhibitors (5-aza-CdR or U0126) for 24h, the effects of arsenite on RECK, MMP-9, -2, uPA and VEGF expression were suppressed.	arsenite	101-109	matrix metallopeptidase 9	Homo sapiens	119-124
21167264-10	2011	However, when the cells were pretreated with inhibitors (5-aza-CdR or U0126) for 24h, the effects of arsenite on RECK, MMP-9, -2, uPA and VEGF expression were suppressed.	arsenite	101-109	vascular endothelial growth factor A	Homo sapiens	138-142
21167264-0	2011	Effects of DNMT and MEK inhibitors on the expression of RECK, MMP-9, -2, uPA and VEGF in response to arsenite stimulation in human uroepithelial cells.	arsenite	101-109	mitogen-activated protein kinase kinase 7	Homo sapiens	20-23
21167264-12	2011	In in vivo study, our results showed the RECK protein expression was reduced and the expression of MMP-9, -2, uPA and VEGF increased in arsenite treatment groups.	arsenite	136-144	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	41-45
21167264-12	2011	In in vivo study, our results showed the RECK protein expression was reduced and the expression of MMP-9, -2, uPA and VEGF increased in arsenite treatment groups.	arsenite	136-144	matrix metallopeptidase 9	Homo sapiens	99-104
21167264-0	2011	Effects of DNMT and MEK inhibitors on the expression of RECK, MMP-9, -2, uPA and VEGF in response to arsenite stimulation in human uroepithelial cells.	arsenite	101-109	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	56-60
21167264-12	2011	In in vivo study, our results showed the RECK protein expression was reduced and the expression of MMP-9, -2, uPA and VEGF increased in arsenite treatment groups.	arsenite	136-144	proline rich acidic protein 1	Homo sapiens	110-113
21167264-12	2011	In in vivo study, our results showed the RECK protein expression was reduced and the expression of MMP-9, -2, uPA and VEGF increased in arsenite treatment groups.	arsenite	136-144	vascular endothelial growth factor A	Homo sapiens	118-122
21167264-0	2011	Effects of DNMT and MEK inhibitors on the expression of RECK, MMP-9, -2, uPA and VEGF in response to arsenite stimulation in human uroepithelial cells.	arsenite	101-109	matrix metallopeptidase 9	Homo sapiens	62-67
21167264-13	2011	In conclusion, our results support the notion that arsenite might cause the histologic changes, RECK, MMP-9, -2, uPA and VEGF dysregulation through epigenetic inactivation and ERK1/2 activation in SV-HUC-1 cells.	arsenite	51-59	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	96-100
21167264-0	2011	Effects of DNMT and MEK inhibitors on the expression of RECK, MMP-9, -2, uPA and VEGF in response to arsenite stimulation in human uroepithelial cells.	arsenite	101-109	proline rich acidic protein 1	Homo sapiens	73-76
21167264-13	2011	In conclusion, our results support the notion that arsenite might cause the histologic changes, RECK, MMP-9, -2, uPA and VEGF dysregulation through epigenetic inactivation and ERK1/2 activation in SV-HUC-1 cells.	arsenite	51-59	matrix metallopeptidase 9	Homo sapiens	102-107
21167264-0	2011	Effects of DNMT and MEK inhibitors on the expression of RECK, MMP-9, -2, uPA and VEGF in response to arsenite stimulation in human uroepithelial cells.	arsenite	101-109	vascular endothelial growth factor A	Homo sapiens	81-85
21167264-13	2011	In conclusion, our results support the notion that arsenite might cause the histologic changes, RECK, MMP-9, -2, uPA and VEGF dysregulation through epigenetic inactivation and ERK1/2 activation in SV-HUC-1 cells.	arsenite	51-59	proline rich acidic protein 1	Homo sapiens	113-116
21167264-5	2011	The purpose of the study was to investigate the relationship between the expression of RECK, MMP-9, -2, uPA and VEGF in arsenite-treated human and rat uroepithelial cells.	arsenite	120-128	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	87-91
21167264-13	2011	In conclusion, our results support the notion that arsenite might cause the histologic changes, RECK, MMP-9, -2, uPA and VEGF dysregulation through epigenetic inactivation and ERK1/2 activation in SV-HUC-1 cells.	arsenite	51-59	vascular endothelial growth factor A	Homo sapiens	121-125
21167264-5	2011	The purpose of the study was to investigate the relationship between the expression of RECK, MMP-9, -2, uPA and VEGF in arsenite-treated human and rat uroepithelial cells.	arsenite	120-128	matrix metallopeptidase 9	Homo sapiens	93-98
21167264-13	2011	In conclusion, our results support the notion that arsenite might cause the histologic changes, RECK, MMP-9, -2, uPA and VEGF dysregulation through epigenetic inactivation and ERK1/2 activation in SV-HUC-1 cells.	arsenite	51-59	mitogen-activated protein kinase 3	Homo sapiens	176-182
21167264-5	2011	The purpose of the study was to investigate the relationship between the expression of RECK, MMP-9, -2, uPA and VEGF in arsenite-treated human and rat uroepithelial cells.	arsenite	120-128	proline rich acidic protein 1	Homo sapiens	104-107
21167264-5	2011	The purpose of the study was to investigate the relationship between the expression of RECK, MMP-9, -2, uPA and VEGF in arsenite-treated human and rat uroepithelial cells.	arsenite	120-128	vascular endothelial growth factor A	Homo sapiens	112-116
21167264-8	2011	We demonstrated the effect of arsenite on methylation status of RECK promoter as determined by using methylation-specific PCR (MSP).	arsenite	30-38	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	64-68
20571777-1	2011	Human arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite.	arsenite	101-109	arsenite methyltransferase	Homo sapiens	6-52
21303554-1	2011	BACKGROUND: Studies have shown that metallothionein 3 (MT-3) is not expressed in normal urothelium or in the UROtsa cell line, but is expressed in urothelial cancer and in tumors generated from the UROtsa cells that have been transformed by cadmium (Cd+2) or arsenite (As+3).The present study had two major goals.	arsenite	259-267	metallothionein 3	Homo sapiens	36-53
21303554-1	2011	BACKGROUND: Studies have shown that metallothionein 3 (MT-3) is not expressed in normal urothelium or in the UROtsa cell line, but is expressed in urothelial cancer and in tumors generated from the UROtsa cells that have been transformed by cadmium (Cd+2) or arsenite (As+3).The present study had two major goals.	arsenite	259-267	metallothionein 3	Homo sapiens	55-59
20571777-1	2011	Human arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite.	arsenite	101-109	arsenite methyltransferase	Homo sapiens	54-59
20835880-5	2011	Moreover, the results using EMSA and Supershift assays indicate that p85alpha is crucial for arsenite-induced activation of the heat-shock transcription factor 1 (HSF-1), which is responsible for transcription of inducible Hsp70.	arsenite	93-101	heat shock factor 1	Mus musculus	128-161
20835880-0	2011	Arsenite stabilizes HIF-1alpha protein through p85alpha-mediated up-regulation of inducible Hsp70 protein expression.	arsenite	0-8	hypoxia inducible factor 1, alpha subunit	Mus musculus	20-30
20835880-5	2011	Moreover, the results using EMSA and Supershift assays indicate that p85alpha is crucial for arsenite-induced activation of the heat-shock transcription factor 1 (HSF-1), which is responsible for transcription of inducible Hsp70.	arsenite	93-101	heat shock factor 1	Mus musculus	163-168
20835880-0	2011	Arsenite stabilizes HIF-1alpha protein through p85alpha-mediated up-regulation of inducible Hsp70 protein expression.	arsenite	0-8	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	47-55
20835880-5	2011	Moreover, the results using EMSA and Supershift assays indicate that p85alpha is crucial for arsenite-induced activation of the heat-shock transcription factor 1 (HSF-1), which is responsible for transcription of inducible Hsp70.	arsenite	93-101	heat shock protein 1B	Mus musculus	223-228
20835880-0	2011	Arsenite stabilizes HIF-1alpha protein through p85alpha-mediated up-regulation of inducible Hsp70 protein expression.	arsenite	0-8	heat shock protein 1B	Mus musculus	92-97
20835880-6	2011	Taken together, p85alpha-mediated HIF-1alpha stabilization upon arsenite exposure is specifically through HSF-1 activation and subsequent up-regulation of the inducible Hsp70 expression.	arsenite	64-72	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	16-24
20835880-2	2011	In the present study, we found that arsenite could induce HIF-1alpha protein accumulation in both mouse epidermal Cl41 cells and mouse embryonic fibroblasts (MEFs).	arsenite	36-44	hypoxia inducible factor 1, alpha subunit	Mus musculus	58-68
20835880-6	2011	Taken together, p85alpha-mediated HIF-1alpha stabilization upon arsenite exposure is specifically through HSF-1 activation and subsequent up-regulation of the inducible Hsp70 expression.	arsenite	64-72	hypoxia inducible factor 1, alpha subunit	Mus musculus	34-44
20835880-3	2011	Knockout of p85alpha, a regulatory subunit of PI-3K, in MEFs (p85alpha(-/-)) dramatically decreased the arsenite-induced HIF-1alpha accumulation, indicating that p85alpha is crucial for arsenite effects on the stabilization of HIF-1alpha protein.	arsenite	104-112	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	12-20
20835880-6	2011	Taken together, p85alpha-mediated HIF-1alpha stabilization upon arsenite exposure is specifically through HSF-1 activation and subsequent up-regulation of the inducible Hsp70 expression.	arsenite	64-72	heat shock factor 1	Mus musculus	106-111
20835880-3	2011	Knockout of p85alpha, a regulatory subunit of PI-3K, in MEFs (p85alpha(-/-)) dramatically decreased the arsenite-induced HIF-1alpha accumulation, indicating that p85alpha is crucial for arsenite effects on the stabilization of HIF-1alpha protein.	arsenite	104-112	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	62-70
20835880-3	2011	Knockout of p85alpha, a regulatory subunit of PI-3K, in MEFs (p85alpha(-/-)) dramatically decreased the arsenite-induced HIF-1alpha accumulation, indicating that p85alpha is crucial for arsenite effects on the stabilization of HIF-1alpha protein.	arsenite	104-112	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	62-70
20835880-6	2011	Taken together, p85alpha-mediated HIF-1alpha stabilization upon arsenite exposure is specifically through HSF-1 activation and subsequent up-regulation of the inducible Hsp70 expression.	arsenite	64-72	heat shock protein 1B	Mus musculus	169-174
20835880-3	2011	Knockout of p85alpha, a regulatory subunit of PI-3K, in MEFs (p85alpha(-/-)) dramatically decreased the arsenite-induced HIF-1alpha accumulation, indicating that p85alpha is crucial for arsenite effects on the stabilization of HIF-1alpha protein.	arsenite	104-112	hypoxia inducible factor 1, alpha subunit	Mus musculus	121-131
20835880-3	2011	Knockout of p85alpha, a regulatory subunit of PI-3K, in MEFs (p85alpha(-/-)) dramatically decreased the arsenite-induced HIF-1alpha accumulation, indicating that p85alpha is crucial for arsenite effects on the stabilization of HIF-1alpha protein.	arsenite	186-194	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	12-20
21266075-5	2011	The model simulates uptake of arsenite (iAsIII) via aquaporin isozymes 9 (AQP9s), glutathione (GSH) conjugation, methylation by arsenic methyltransferase (AS3MT), efflux through multidrug resistant proteins (MRPs) and the induced antioxidant response via thioredoxin reductase (TR) activity.	arsenite	30-38	arsenite methyltransferase	Homo sapiens	155-160
20835880-3	2011	Knockout of p85alpha, a regulatory subunit of PI-3K, in MEFs (p85alpha(-/-)) dramatically decreased the arsenite-induced HIF-1alpha accumulation, indicating that p85alpha is crucial for arsenite effects on the stabilization of HIF-1alpha protein.	arsenite	186-194	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	62-70
20835880-3	2011	Knockout of p85alpha, a regulatory subunit of PI-3K, in MEFs (p85alpha(-/-)) dramatically decreased the arsenite-induced HIF-1alpha accumulation, indicating that p85alpha is crucial for arsenite effects on the stabilization of HIF-1alpha protein.	arsenite	186-194	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	62-70
20835880-3	2011	Knockout of p85alpha, a regulatory subunit of PI-3K, in MEFs (p85alpha(-/-)) dramatically decreased the arsenite-induced HIF-1alpha accumulation, indicating that p85alpha is crucial for arsenite effects on the stabilization of HIF-1alpha protein.	arsenite	186-194	hypoxia inducible factor 1, alpha subunit	Mus musculus	121-131
20835880-4	2011	Our further studies suggest that arsenite could induce inducible Hsp70 expression, and transfection of inducible Hsp70 into p85alpha(-/-) MEFs could restore HIF-1alpha protein accumulation.	arsenite	33-41	heat shock protein 1B	Mus musculus	65-70
20835880-5	2011	Moreover, the results using EMSA and Supershift assays indicate that p85alpha is crucial for arsenite-induced activation of the heat-shock transcription factor 1 (HSF-1), which is responsible for transcription of inducible Hsp70.	arsenite	93-101	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	69-77
21321321-9	2011	Expressions of metallothionein-1 and heme oxygenase-1, biomarkers for metal toxicity, were increased 2-5 folds by arsenite, arsenate, MeHg and HgCl(2), but not by realgar, cinnabar and AGNH.	arsenite	114-122	metallothionein 1	Mus musculus	15-32
21321321-9	2011	Expressions of metallothionein-1 and heme oxygenase-1, biomarkers for metal toxicity, were increased 2-5 folds by arsenite, arsenate, MeHg and HgCl(2), but not by realgar, cinnabar and AGNH.	arsenite	114-122	heme oxygenase 1	Mus musculus	37-53
21321321-11	2011	Expressions of cell adhesion gene S100a9 and E-cadherin were altered by HgCl(2), arsenite and realgar.	arsenite	81-89	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	34-40
21321321-11	2011	Expressions of cell adhesion gene S100a9 and E-cadherin were altered by HgCl(2), arsenite and realgar.	arsenite	81-89	cadherin 1	Mus musculus	45-55
21094152-13	2011	The expression of metallothionein-1, a biomarker of metal exposure, was increased 4-10-fold by arsenite and HgCl2, but was unchanged by AGNH, realgar and cinnabar.	arsenite	95-103	metallothionein 1	Mus musculus	18-35
22040890-0	2011	Involvement of c-Met- and phosphatidylinositol 3-kinase dependent pathways in arsenite-induced downregulation of catalase in hepatoma cells.	arsenite	78-86	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	15-20
21040761-10	2011	In addition, the Cyclin-D1 increased expression but decreased p16 expression in arsenite-treated SV-HUC-1 cells.	arsenite	80-88	cyclin D1	Homo sapiens	17-26
21040761-10	2011	In addition, the Cyclin-D1 increased expression but decreased p16 expression in arsenite-treated SV-HUC-1 cells.	arsenite	80-88	cyclin dependent kinase inhibitor 2A	Homo sapiens	62-65
21040761-11	2011	However, when cells were pretreated with inhibitors (5-aza-CdR or U0126), the effects of arsenite on Cyclin-D1 and p16 expression were suppressed.	arsenite	89-97	cyclin D1	Homo sapiens	101-110
21040761-11	2011	However, when cells were pretreated with inhibitors (5-aza-CdR or U0126), the effects of arsenite on Cyclin-D1 and p16 expression were suppressed.	arsenite	89-97	cyclin dependent kinase inhibitor 2A	Homo sapiens	115-118
22040890-0	2011	Involvement of c-Met- and phosphatidylinositol 3-kinase dependent pathways in arsenite-induced downregulation of catalase in hepatoma cells.	arsenite	78-86	catalase	Homo sapiens	113-121
22040890-2	2011	Arsenite decreases catalase activity; it activates phosphatidylinositol 3-kinase (PI3K) and its key downstream effector Akt in a variety of cells.	arsenite	0-8	catalase	Homo sapiens	19-27
22040890-2	2011	Arsenite decreases catalase activity; it activates phosphatidylinositol 3-kinase (PI3K) and its key downstream effector Akt in a variety of cells.	arsenite	0-8	AKT serine/threonine kinase 1	Homo sapiens	120-123
22040890-5	2011	To examine the involvement of c-Met and PI3K pathways in the arsenite-induced downregulation of catalase, catalase mRNA and protein expression were analyzed in the human hepatoma cell line HepG2 treated with arsenite and either an inhibitor of c-Met (PHA665752 (PHA)) or of PI3K (LY294002 (LY)).	arsenite	61-69	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	30-35
22040890-5	2011	To examine the involvement of c-Met and PI3K pathways in the arsenite-induced downregulation of catalase, catalase mRNA and protein expression were analyzed in the human hepatoma cell line HepG2 treated with arsenite and either an inhibitor of c-Met (PHA665752 (PHA)) or of PI3K (LY294002 (LY)).	arsenite	61-69	catalase	Homo sapiens	96-104
22040890-5	2011	To examine the involvement of c-Met and PI3K pathways in the arsenite-induced downregulation of catalase, catalase mRNA and protein expression were analyzed in the human hepatoma cell line HepG2 treated with arsenite and either an inhibitor of c-Met (PHA665752 (PHA)) or of PI3K (LY294002 (LY)).	arsenite	61-69	catalase	Homo sapiens	106-114
22040890-5	2011	To examine the involvement of c-Met and PI3K pathways in the arsenite-induced downregulation of catalase, catalase mRNA and protein expression were analyzed in the human hepatoma cell line HepG2 treated with arsenite and either an inhibitor of c-Met (PHA665752 (PHA)) or of PI3K (LY294002 (LY)).	arsenite	61-69	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	244-249
22040890-6	2011	Arsenite treatment markedly activated Akt and decreased the levels of both catalase mRNA and protein.	arsenite	0-8	AKT serine/threonine kinase 1	Homo sapiens	38-41
22040890-6	2011	Arsenite treatment markedly activated Akt and decreased the levels of both catalase mRNA and protein.	arsenite	0-8	catalase	Homo sapiens	75-83
22040890-7	2011	Both PHA and LY attenuated arsenite-induced activation of Akt.	arsenite	27-35	AKT serine/threonine kinase 1	Homo sapiens	58-61
22040890-8	2011	PHA and LY treatment also prevented the inhibitory effect of arsenite on catalase protein expression but did not affect the level of catalase mRNA.	arsenite	61-69	catalase	Homo sapiens	73-81
22040890-9	2011	These findings suggest that arsenite-induced inhibition of catalase expression is regulated at the mRNA and post-transcriptional levels in HepG2 cells, and that the post-transcriptional regulation is mediated via c-Met- and PI3K-dependent mechanisms.	arsenite	28-36	catalase	Homo sapiens	59-67
22040890-9	2011	These findings suggest that arsenite-induced inhibition of catalase expression is regulated at the mRNA and post-transcriptional levels in HepG2 cells, and that the post-transcriptional regulation is mediated via c-Met- and PI3K-dependent mechanisms.	arsenite	28-36	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	213-218
20805060-4	2011	RESULTS: In cultured human keratinocyte HaCaT cells, inorganic arsenite (iAs3+) enhanced the protein accumulation of long isoforms (120-140 kDa) of NRF1 in a dose- and time-dependent fashion.	arsenite	63-71	NFE2 like bZIP transcription factor 1	Homo sapiens	148-152
21297353-0	2011	Chronic exposure to arsenite induces S100A8 and S100A9 expression in rat RBL-2H3 mast cells.	arsenite	20-28	S100 calcium binding protein A8	Rattus norvegicus	37-43
22102309-0	2011	Induction of cyclin D1 by arsenite and UVB-irradiation in human keratinocytes.	arsenite	26-34	cyclin D1	Homo sapiens	13-22
22102309-5	2011	Here, we employed this system to demonstrate concordant cyclin D1-related induction profiles of ultraviolet B radiation and arsenite using cDNA microarray analysis.	arsenite	124-132	cyclin D1	Homo sapiens	56-65
21297353-0	2011	Chronic exposure to arsenite induces S100A8 and S100A9 expression in rat RBL-2H3 mast cells.	arsenite	20-28	S100 calcium binding protein A9	Rattus norvegicus	48-54
22129753-2	2011	We found that the knockdown of YPT1, ERG8, or RKI1 enhanced arsenite sensitivity  in yeast.	arsenite	60-68	Rab family GTPase YPT1	Saccharomyces cerevisiae S288C	31-35
21297353-2	2011	Upregulated genes include calcium-binding S100 proteins such as S100A9, S100A10, S100A6, and S100A13, and granzymes B and C. Among S100 proteins, S100A9 showed the highest expression (8.62-fold of untreated cells) after 4-weeks of exposure to arsenite.	arsenite	243-251	S100 calcium binding protein A9	Rattus norvegicus	146-152
21297353-4	2011	The results demonstrated that exposure of RBL-2H3 cells to arsenite for a few weeks induces marked increases in mRNA levels of S100A8 and S100A9.	arsenite	59-67	RB transcriptional corepressor like 2	Rattus norvegicus	42-47
22129753-2	2011	We found that the knockdown of YPT1, ERG8, or RKI1 enhanced arsenite sensitivity  in yeast.	arsenite	60-68	phosphomevalonate kinase	Saccharomyces cerevisiae S288C	37-41
22129753-2	2011	We found that the knockdown of YPT1, ERG8, or RKI1 enhanced arsenite sensitivity  in yeast.	arsenite	60-68	ribose-5-phosphate isomerase RKI1	Saccharomyces cerevisiae S288C	46-50
21297353-4	2011	The results demonstrated that exposure of RBL-2H3 cells to arsenite for a few weeks induces marked increases in mRNA levels of S100A8 and S100A9.	arsenite	59-67	S100 calcium binding protein A8	Rattus norvegicus	127-133
21297353-4	2011	The results demonstrated that exposure of RBL-2H3 cells to arsenite for a few weeks induces marked increases in mRNA levels of S100A8 and S100A9.	arsenite	59-67	S100 calcium binding protein A9	Rattus norvegicus	138-144
21059470-7	2010	Speciation study revealed arsenite fraction was mainly eliminated through milk, whereas organoarsenic species were mainly excreted through feces.	arsenite	26-34	Weaning weight-maternal milk	Bos taurus	74-78
21655328-6	2011	Next, we use these novel inhibitors to pinpoint the time of Hog1 action during recovery from G(1) checkpoint arrest, providing further evidence for a specific role of Hog1 in regulating cell cycle resumption during arsenite stress.	arsenite	215-223	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	60-64
21655328-6	2011	Next, we use these novel inhibitors to pinpoint the time of Hog1 action during recovery from G(1) checkpoint arrest, providing further evidence for a specific role of Hog1 in regulating cell cycle resumption during arsenite stress.	arsenite	215-223	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	167-171
20862710-0	2010	Activation of the p38 MAPK/Akt/ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arsenite-induced cell proliferation.	arsenite	130-138	AKT serine/threonine kinase 1	Homo sapiens	27-30
20862710-0	2010	Activation of the p38 MAPK/Akt/ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arsenite-induced cell proliferation.	arsenite	130-138	mitogen-activated protein kinase 3	Homo sapiens	31-37
20862710-0	2010	Activation of the p38 MAPK/Akt/ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arsenite-induced cell proliferation.	arsenite	130-138	cell division cycle 6	Homo sapiens	99-103
20862710-0	2010	Activation of the p38 MAPK/Akt/ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arsenite-induced cell proliferation.	arsenite	130-138	cyclin D1	Homo sapiens	108-117
20837119-0	2010	SPARC gene expression is repressed in human urothelial cells (UROtsa) exposed to or malignantly transformed by cadmium or arsenite.	arsenite	122-130	secreted protein acidic and cysteine rich	Homo sapiens	0-5
21039781-3	2010	We have identified the histidine kinase (AroS) and the cognate response regulator (AroR) involved in the arsenite-dependent transcriptional regulation of the arsenite oxidase aroBA operon.	arsenite	105-113	ribosomal protein S19 binding protein 1	Homo sapiens	41-45
21039781-9	2010	Mutational analysis in NT-26 confirmed that both proteins are essential for arsenite oxidation and the AroS mutant affected growth with arsenite, also implicating it in the regulation of arsenite tolerance.	arsenite	136-144	ribosomal protein S19 binding protein 1	Homo sapiens	103-107
21039781-9	2010	Mutational analysis in NT-26 confirmed that both proteins are essential for arsenite oxidation and the AroS mutant affected growth with arsenite, also implicating it in the regulation of arsenite tolerance.	arsenite	136-144	ribosomal protein S19 binding protein 1	Homo sapiens	103-107
21139346-0	2010	Overexpression of FAP7, MIG3, TMA19, or YLR392c confers resistance to arsenite on Saccharomyces cerevisiae.	arsenite	70-78	nucleoside-triphosphatase	Saccharomyces cerevisiae S288C	18-22
21139346-0	2010	Overexpression of FAP7, MIG3, TMA19, or YLR392c confers resistance to arsenite on Saccharomyces cerevisiae.	arsenite	70-78	Mig3p	Saccharomyces cerevisiae S288C	24-28
21139346-0	2010	Overexpression of FAP7, MIG3, TMA19, or YLR392c confers resistance to arsenite on Saccharomyces cerevisiae.	arsenite	70-78	Tma19p	Saccharomyces cerevisiae S288C	30-35
21139346-2	2010	Employing a Saccharomyces cerevisiae open reading frame (ORF) library, four genes associated with arsenite resistance, FAP7, MIG3, TMA19, and YLR392c, were identified.	arsenite	98-106	nucleoside-triphosphatase	Saccharomyces cerevisiae S288C	119-123
21139346-2	2010	Employing a Saccharomyces cerevisiae open reading frame (ORF) library, four genes associated with arsenite resistance, FAP7, MIG3, TMA19, and YLR392c, were identified.	arsenite	98-106	Mig3p	Saccharomyces cerevisiae S288C	125-129
21139346-2	2010	Employing a Saccharomyces cerevisiae open reading frame (ORF) library, four genes associated with arsenite resistance, FAP7, MIG3, TMA19, and YLR392c, were identified.	arsenite	98-106	Tma19p	Saccharomyces cerevisiae S288C	131-136
21062045-1	2010	Using TiO(2) photocatalyst, arsenite, As(III), can be rapidly oxidized to arsenate, As(V), which is less toxic and less mobile in the aquatic environment.	arsenite	28-36	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	84-89
20864298-2	2010	METHODS: The ability of MK2i to reduce HSP27 phosphorylation and cell migration was evaluated in A7R5 cells stimulated with arsenite or lysophosphatidic acid.	arsenite	124-132	heat shock protein family B (small) member 1	Rattus norvegicus	39-44
20837119-3	2010	The objective of this study was to determine if SPARC expression was altered in cadmium (Cd(2+)) and arsenite (As(3+)) induced bladder cancer and if these alterations were present in archival specimens of human bladder cancer.	arsenite	101-109	secreted protein acidic and cysteine rich	Homo sapiens	48-53
20837119-8	2010	Acute exposure of UROtsa cells to both cadmium and arsenite reduced the expression of SPARC through a mechanism that did not involve changes in DNA methylation or histone acetylation.	arsenite	51-59	secreted protein acidic and cysteine rich	Homo sapiens	86-91
20600853-3	2010	However, the PDE4 inhibitor rolipram decreases arsenite-induced SGs and increases the amount of PBs, while arsenite challenge ablates rolipram-induced PDE4A4 aggregates.	arsenite	47-55	phosphodiesterase 4A	Homo sapiens	13-17
20655873-0	2010	The yeast permease Acr3p is a dual arsenite and antimonite plasma membrane transporter.	arsenite	35-43	Arr3p	Saccharomyces cerevisiae S288C	19-24
20655873-3	2010	Here, we show that the yeast Acr3p mediates not only high-level resistance to arsenite but also moderate tolerance to antimonite.	arsenite	78-86	Arr3p	Saccharomyces cerevisiae S288C	29-34
20655873-6	2010	Moreover, both antimonite and arsenite induce transcription of the ACR3 gene resulting in the accumulation of Acr3 transporter at the plasma membrane.	arsenite	30-38	Arr3p	Saccharomyces cerevisiae S288C	67-71
20655873-6	2010	Moreover, both antimonite and arsenite induce transcription of the ACR3 gene resulting in the accumulation of Acr3 transporter at the plasma membrane.	arsenite	30-38	Arr3p	Saccharomyces cerevisiae S288C	110-114
20655873-9	2010	Finally, transport experiments confirmed that Acr3p indeed mediates efflux of antimonite and thus possesses a dual arsenite and antimonite specificity.	arsenite	115-123	Arr3p	Saccharomyces cerevisiae S288C	46-51
20621156-0	2010	New insights into the mechanism of arsenite methylation with the recombinant human arsenic (+3) methyltransferase (hAS3MT).	arsenite	35-43	arsenite methyltransferase	Homo sapiens	115-121
20621156-7	2010	Initial velocity studies illuminate an ordered sequence for the binding of SAM and arsenite to the hAS3MT; while GSH should probably be placed either as the first reactant or as a reactant combining with the enzyme only after products have been released.	arsenite	83-91	arsenite methyltransferase	Homo sapiens	99-105
20954712-0	2010	Arsenite induces endothelial cell permeability increase through a reactive oxygen species-vascular endothelial growth factor pathway.	arsenite	0-8	vascular endothelial growth factor A	Mus musculus	90-124
20954712-4	2010	The mouse brain vascular endothelial cell bEnd3 monolayer was exposed to arsenite for 1, 3, and 6 days.	arsenite	73-81	BEN domain containing 3	Mus musculus	42-47
20954712-7	2010	The roles of ROS and VEGF in arsenite-induced permeability was determined by inhibiting ROS with antioxidants and immuno-depleting VEGF with a VEGF antibody.	arsenite	29-37	vascular endothelial growth factor A	Mus musculus	21-25
20954712-7	2010	The roles of ROS and VEGF in arsenite-induced permeability was determined by inhibiting ROS with antioxidants and immuno-depleting VEGF with a VEGF antibody.	arsenite	29-37	vascular endothelial growth factor A	Mus musculus	131-135
20954712-7	2010	The roles of ROS and VEGF in arsenite-induced permeability was determined by inhibiting ROS with antioxidants and immuno-depleting VEGF with a VEGF antibody.	arsenite	29-37	vascular endothelial growth factor A	Mus musculus	131-135
20954712-8	2010	We observed that arsenite increased bEnd3 monolayer permeability, elevated the production of cellular ROS, and increased VEGF release.	arsenite	17-25	BEN domain containing 3	Mus musculus	36-41
20954712-8	2010	We observed that arsenite increased bEnd3 monolayer permeability, elevated the production of cellular ROS, and increased VEGF release.	arsenite	17-25	vascular endothelial growth factor A	Mus musculus	121-125
20954712-9	2010	VE-cadherin and ZO-1 disruptions were also found in cells treated with arsenite.	arsenite	71-79	cadherin 5	Mus musculus	0-11
20954712-9	2010	VE-cadherin and ZO-1 disruptions were also found in cells treated with arsenite.	arsenite	71-79	tight junction protein 1	Mus musculus	16-20
20954712-10	2010	Furthermore, both antioxidant (N-acetyl cysteine and tempol) and the VEGF antibody treatments significantly lowered the arsenite-induced permeability of the bEnd3 monolayer as well as VEGF expression.	arsenite	120-128	vascular endothelial growth factor A	Mus musculus	69-73
20954712-10	2010	Furthermore, both antioxidant (N-acetyl cysteine and tempol) and the VEGF antibody treatments significantly lowered the arsenite-induced permeability of the bEnd3 monolayer as well as VEGF expression.	arsenite	120-128	BEN domain containing 3	Mus musculus	157-162
20954712-12	2010	Our data suggest that the increase in VEGF expression caused by ROS may play an important role in the arsenite-induced increase in endothelial cell permeability.	arsenite	102-110	vascular endothelial growth factor A	Mus musculus	38-42
20740275-5	2010	However, lack of URE2 specifically caused sensitivity to arsenite but not to arsenate.	arsenite	57-65	glutathione peroxidase	Saccharomyces cerevisiae S288C	17-21
20740275-6	2010	The protective role of URE2 against arsenite depended solely on the GST-encoding 3"-end portion of the gene.	arsenite	36-44	glutathione peroxidase	Saccharomyces cerevisiae S288C	23-27
20818482-9	2010	Concordantly, we found that, if most cells in the culture are still alive (i.e. up to 10 microM arsenite), they show a treatment-dependent increase in the concentration of SOD1.	arsenite	96-104	superoxide dismutase 1	Rattus norvegicus	172-176
20818482-12	2010	Here we also report that, in cells exposed to high doses of arsenite, an anti-PIPPin antibody-positive faster migrating protein appears.	arsenite	60-68	cold shock domain containing C2	Rattus norvegicus	78-84
20558743-8	2010	Differential oxidation of glutathione or thioredoxin proteins by copper (II) or arsenite, respectively, provided further support for the thioredoxin/peroxiredoxin system as the major contributor to mitochondrial H(2)O(2) removal.	arsenite	80-88	thioredoxin 1	Rattus norvegicus	41-52
20457661-0	2010	Polynucleotide phosphorylase and mitochondrial ATP synthase mediate reduction of arsenate to the more toxic arsenite by forming arsenylated analogues of ADP and ATP.	arsenite	108-116	polyribonucleotide nucleotidyltransferase 1	Homo sapiens	0-28
20558743-8	2010	Differential oxidation of glutathione or thioredoxin proteins by copper (II) or arsenite, respectively, provided further support for the thioredoxin/peroxiredoxin system as the major contributor to mitochondrial H(2)O(2) removal.	arsenite	80-88	thioredoxin 1	Rattus norvegicus	137-148
20654631-2	2010	We have shown that ATF5 is a stress response transcription factor that responds to amino acid limitation, arsenite exposure, or cadmium exposure.	arsenite	106-114	activating transcription factor 5	Homo sapiens	19-23
20654631-5	2010	We also studied the effect of ATF5 knockdown on arsenite-induced CHOP protein expression and arsenite-induced cell death of HepG2 cells.	arsenite	48-56	activating transcription factor 5	Homo sapiens	30-34
20654631-5	2010	We also studied the effect of ATF5 knockdown on arsenite-induced CHOP protein expression and arsenite-induced cell death of HepG2 cells.	arsenite	48-56	DNA damage inducible transcript 3	Homo sapiens	65-69
20654631-8	2010	Furthermore, the existence of either AARE1 or activating protein-1 (AP-1) site is sufficient for transcriptional activation of the CHOP gene promoter by arsenite exposure, although complete induction requires the existence of both elements.	arsenite	153-161	DNA damage inducible transcript 3	Homo sapiens	131-135
20566634-0	2010	p27 suppresses arsenite-induced Hsp27/Hsp70 expression through inhibiting JNK2/c-Jun- and HSF-1-dependent pathways.	arsenite	15-23	interferon alpha inducible protein 27	Homo sapiens	0-3
20566634-0	2010	p27 suppresses arsenite-induced Hsp27/Hsp70 expression through inhibiting JNK2/c-Jun- and HSF-1-dependent pathways.	arsenite	15-23	heat shock protein family B (small) member 1	Homo sapiens	32-37
20566634-0	2010	p27 suppresses arsenite-induced Hsp27/Hsp70 expression through inhibiting JNK2/c-Jun- and HSF-1-dependent pathways.	arsenite	15-23	heat shock protein family A (Hsp70) member 4	Homo sapiens	38-43
20566634-0	2010	p27 suppresses arsenite-induced Hsp27/Hsp70 expression through inhibiting JNK2/c-Jun- and HSF-1-dependent pathways.	arsenite	15-23	mitogen-activated protein kinase 9	Homo sapiens	74-78
20566634-0	2010	p27 suppresses arsenite-induced Hsp27/Hsp70 expression through inhibiting JNK2/c-Jun- and HSF-1-dependent pathways.	arsenite	15-23	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	79-84
20566634-0	2010	p27 suppresses arsenite-induced Hsp27/Hsp70 expression through inhibiting JNK2/c-Jun- and HSF-1-dependent pathways.	arsenite	15-23	heat shock transcription factor 1	Homo sapiens	90-95
20566634-4	2010	In this study, we found that depletion of p27 expression by either gene knock-out or knockdown approaches resulted in up-regulation of both Hsp27 and Hsp70 expression at mRNA- and promoter-derived transcription as well as protein levels upon arsenite exposure, indicating that p27 provides a negative signal for regulating the expression of Hsp27 and Hsp70.	arsenite	242-250	interferon alpha inducible protein 27	Homo sapiens	42-45
20566634-4	2010	In this study, we found that depletion of p27 expression by either gene knock-out or knockdown approaches resulted in up-regulation of both Hsp27 and Hsp70 expression at mRNA- and promoter-derived transcription as well as protein levels upon arsenite exposure, indicating that p27 provides a negative signal for regulating the expression of Hsp27 and Hsp70.	arsenite	242-250	heat shock protein family A (Hsp70) member 4	Homo sapiens	150-155
20566634-5	2010	Consistently, arsenite-induced activation of JNK2/c-Jun and HSF-1 pathways was also markedly elevated in p27 knock-out (p27(-/-)) and knockdown (p27 shRNA) cells.	arsenite	14-22	mitogen-activated protein kinase 9	Homo sapiens	45-49
20566634-5	2010	Consistently, arsenite-induced activation of JNK2/c-Jun and HSF-1 pathways was also markedly elevated in p27 knock-out (p27(-/-)) and knockdown (p27 shRNA) cells.	arsenite	14-22	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	50-55
20566634-5	2010	Consistently, arsenite-induced activation of JNK2/c-Jun and HSF-1 pathways was also markedly elevated in p27 knock-out (p27(-/-)) and knockdown (p27 shRNA) cells.	arsenite	14-22	heat shock transcription factor 1	Homo sapiens	60-65
20566634-5	2010	Consistently, arsenite-induced activation of JNK2/c-Jun and HSF-1 pathways was also markedly elevated in p27 knock-out (p27(-/-)) and knockdown (p27 shRNA) cells.	arsenite	14-22	interferon alpha inducible protein 27	Homo sapiens	105-108
20566634-5	2010	Consistently, arsenite-induced activation of JNK2/c-Jun and HSF-1 pathways was also markedly elevated in p27 knock-out (p27(-/-)) and knockdown (p27 shRNA) cells.	arsenite	14-22	interferon alpha inducible protein 27	Homo sapiens	120-123
20566634-5	2010	Consistently, arsenite-induced activation of JNK2/c-Jun and HSF-1 pathways was also markedly elevated in p27 knock-out (p27(-/-)) and knockdown (p27 shRNA) cells.	arsenite	14-22	interferon alpha inducible protein 27	Homo sapiens	120-123
20566634-6	2010	Moreover, interference with the expression or function of JNK2, c-Jun, and HSF-1, but not JNK1, led to dramatic inhibition of arsenite-induced Hsp27 and Hsp70 expression.	arsenite	126-134	mitogen-activated protein kinase 9	Homo sapiens	58-62
20566634-6	2010	Moreover, interference with the expression or function of JNK2, c-Jun, and HSF-1, but not JNK1, led to dramatic inhibition of arsenite-induced Hsp27 and Hsp70 expression.	arsenite	126-134	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	64-69
20566634-6	2010	Moreover, interference with the expression or function of JNK2, c-Jun, and HSF-1, but not JNK1, led to dramatic inhibition of arsenite-induced Hsp27 and Hsp70 expression.	arsenite	126-134	heat shock transcription factor 1	Homo sapiens	75-80
20566634-6	2010	Moreover, interference with the expression or function of JNK2, c-Jun, and HSF-1, but not JNK1, led to dramatic inhibition of arsenite-induced Hsp27 and Hsp70 expression.	arsenite	126-134	heat shock protein family B (small) member 1	Homo sapiens	143-148
20566634-6	2010	Moreover, interference with the expression or function of JNK2, c-Jun, and HSF-1, but not JNK1, led to dramatic inhibition of arsenite-induced Hsp27 and Hsp70 expression.	arsenite	126-134	heat shock protein family A (Hsp70) member 4	Homo sapiens	153-158
20566634-7	2010	Collectively, our results demonstrate that p27 suppresses Hsp27 and Hsp70 expression at the transcriptional level specifically through JNK2/c-Jun- and HSF-1-dependent pathways upon arsenite exposure, which provides additional important molecular mechanisms for the tumor-suppressive function of p27.	arsenite	181-189	interferon alpha inducible protein 27	Homo sapiens	43-46
20566634-7	2010	Collectively, our results demonstrate that p27 suppresses Hsp27 and Hsp70 expression at the transcriptional level specifically through JNK2/c-Jun- and HSF-1-dependent pathways upon arsenite exposure, which provides additional important molecular mechanisms for the tumor-suppressive function of p27.	arsenite	181-189	heat shock protein family B (small) member 1	Homo sapiens	58-63
20566634-7	2010	Collectively, our results demonstrate that p27 suppresses Hsp27 and Hsp70 expression at the transcriptional level specifically through JNK2/c-Jun- and HSF-1-dependent pathways upon arsenite exposure, which provides additional important molecular mechanisms for the tumor-suppressive function of p27.	arsenite	181-189	heat shock protein family A (Hsp70) member 4	Homo sapiens	68-73
20566634-7	2010	Collectively, our results demonstrate that p27 suppresses Hsp27 and Hsp70 expression at the transcriptional level specifically through JNK2/c-Jun- and HSF-1-dependent pathways upon arsenite exposure, which provides additional important molecular mechanisms for the tumor-suppressive function of p27.	arsenite	181-189	mitogen-activated protein kinase 9	Homo sapiens	135-139
20566634-7	2010	Collectively, our results demonstrate that p27 suppresses Hsp27 and Hsp70 expression at the transcriptional level specifically through JNK2/c-Jun- and HSF-1-dependent pathways upon arsenite exposure, which provides additional important molecular mechanisms for the tumor-suppressive function of p27.	arsenite	181-189	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	140-145
20566634-7	2010	Collectively, our results demonstrate that p27 suppresses Hsp27 and Hsp70 expression at the transcriptional level specifically through JNK2/c-Jun- and HSF-1-dependent pathways upon arsenite exposure, which provides additional important molecular mechanisms for the tumor-suppressive function of p27.	arsenite	181-189	heat shock transcription factor 1	Homo sapiens	151-156
20566634-7	2010	Collectively, our results demonstrate that p27 suppresses Hsp27 and Hsp70 expression at the transcriptional level specifically through JNK2/c-Jun- and HSF-1-dependent pathways upon arsenite exposure, which provides additional important molecular mechanisms for the tumor-suppressive function of p27.	arsenite	181-189	interferon alpha inducible protein 27	Homo sapiens	60-63
20654631-9	2010	We also demonstrated that knockdown of ATF5 reduced arsenite-induced CHOP protein expression and arsenite-induced cell death of HepG2 cells.	arsenite	52-60	activating transcription factor 5	Homo sapiens	39-43
20654631-9	2010	We also demonstrated that knockdown of ATF5 reduced arsenite-induced CHOP protein expression and arsenite-induced cell death of HepG2 cells.	arsenite	52-60	DNA damage inducible transcript 3	Homo sapiens	69-73
20654631-9	2010	We also demonstrated that knockdown of ATF5 reduced arsenite-induced CHOP protein expression and arsenite-induced cell death of HepG2 cells.	arsenite	97-105	activating transcription factor 5	Homo sapiens	39-43
20654631-10	2010	SIGNIFICANCE: These results suggested that the CHOP gene is a potential target for ATF5, and that ATF5 raises the arsenite-induced CHOP gene expression level via the AARE1 site in HepG2 cells.	arsenite	114-122	DNA damage inducible transcript 3	Homo sapiens	47-51
20654631-10	2010	SIGNIFICANCE: These results suggested that the CHOP gene is a potential target for ATF5, and that ATF5 raises the arsenite-induced CHOP gene expression level via the AARE1 site in HepG2 cells.	arsenite	114-122	activating transcription factor 5	Homo sapiens	83-87
20654631-10	2010	SIGNIFICANCE: These results suggested that the CHOP gene is a potential target for ATF5, and that ATF5 raises the arsenite-induced CHOP gene expression level via the AARE1 site in HepG2 cells.	arsenite	114-122	activating transcription factor 5	Homo sapiens	98-102
20654631-10	2010	SIGNIFICANCE: These results suggested that the CHOP gene is a potential target for ATF5, and that ATF5 raises the arsenite-induced CHOP gene expression level via the AARE1 site in HepG2 cells.	arsenite	114-122	DNA damage inducible transcript 3	Homo sapiens	131-135
20573744-3	2010	We show that LARP4B is a cytosolic protein that accumulates upon arsenite treatment in cellular stress granules.	arsenite	65-73	La ribonucleoprotein 4B	Homo sapiens	13-19
20138265-0	2010	Arsenic species, AS3MT amount, and AS3MT gene expression in different brain regions of mouse exposed to arsenite.	arsenite	104-112	arsenite methyltransferase	Mus musculus	35-40
20589738-4	2010	In the current study, we investigated 4E-BP1 expression in mouse insulinoma line 6 (MIN6) cells treated with arsenite, an inducer of oxidative stress which is another contributor of beta-cell loss.	arsenite	109-117	eukaryotic translation initiation factor 4E binding protein 1	Mus musculus	38-44
20589738-5	2010	We found that arsenite-induced 4E-BP1 expression level was lower than that induced by thapsigargin, an ER stress inducer, although ATF4 was similarly induced by these agents.	arsenite	14-22	eukaryotic translation initiation factor 4E binding protein 1	Mus musculus	31-37
20589738-6	2010	The ratio of the dephosphorylated form of 4E-BP1, which has the highest activity, to phosphorylated forms was, however, greater in MIN6 cells treated with arsenite as compared to that in thapsigargin-treated cells.	arsenite	155-163	eukaryotic translation initiation factor 4E binding protein 1	Mus musculus	42-48
20589738-7	2010	Arsenite-induced 4E-BP1 mRNA and protein expressions were augmented by simultaneous treatment with a c-Jun N-terminal kinase (JNK) specific inhibitor, SP600125.	arsenite	0-8	eukaryotic translation initiation factor 4E binding protein 1	Mus musculus	17-23
20589738-7	2010	Arsenite-induced 4E-BP1 mRNA and protein expressions were augmented by simultaneous treatment with a c-Jun N-terminal kinase (JNK) specific inhibitor, SP600125.	arsenite	0-8	mitogen-activated protein kinase 8	Mus musculus	101-124
20589738-7	2010	Arsenite-induced 4E-BP1 mRNA and protein expressions were augmented by simultaneous treatment with a c-Jun N-terminal kinase (JNK) specific inhibitor, SP600125.	arsenite	0-8	mitogen-activated protein kinase 8	Mus musculus	126-129
20589738-8	2010	The agent also suppressed the level of the dephosphrylated form of 4E-BP1 in arsenite-treated MIN6 cells.	arsenite	77-85	eukaryotic translation initiation factor 4E binding protein 1	Mus musculus	67-73
19733843-0	2010	Arsenite induces aquaglyceroporin 9 expression in murine livers.	arsenite	0-8	aquaporin 9	Mus musculus	17-35
20199942-0	2010	mot-2-Mediated cross talk between nuclear factor-B and p53 is involved in arsenite-induced tumorigenesis of human embryo lung fibroblast cells.	arsenite	74-82	heat shock protein family A (Hsp70) member 9	Homo sapiens	0-5
20199942-0	2010	mot-2-Mediated cross talk between nuclear factor-B and p53 is involved in arsenite-induced tumorigenesis of human embryo lung fibroblast cells.	arsenite	74-82	tumor protein p53	Homo sapiens	55-58
20199942-1	2010	BACKGROUND: Inactivation of p53 is involved in arsenite-induced tumorigenesis; however, the molecular mechanisms remain poorly understood.	arsenite	47-55	tumor protein p53	Homo sapiens	28-31
20199942-2	2010	OBJECTIVE: We investigated the molecular mechanisms underlying the inactivation of p53 and neoplastic transformation induced by arsenite in human embryo lung fibroblast (HELF) cells.	arsenite	128-136	tumor protein p53	Homo sapiens	83-86
20488895-8	2010	Moreover, both the ptlpd1 and ptlpd2 mutants were more sensitive to arsenite than wild-type plants, and the LPD activity in isolated chloroplasts from wild-type plants was sensitive to arsenite but not arsenate.	arsenite	68-76	lipoamide dehydrogenase 1	Arabidopsis thaliana	19-25
20199942-4	2010	We determined the levels and functions of p53, nuclear factor-kappa B (NF-B; a key transcriptional regulator), and mot-2 (a p53 inhibitor) and their relationships in arsenite-induced transformed HELF cells by two-dimensional electrophoresis, reverse-transcriptase polymerase chain reaction, Western blot, immunofluorescence, and co-immunoprecipitation assays.	arsenite	166-174	tumor protein p53	Homo sapiens	42-45
20199942-4	2010	We determined the levels and functions of p53, nuclear factor-kappa B (NF-B; a key transcriptional regulator), and mot-2 (a p53 inhibitor) and their relationships in arsenite-induced transformed HELF cells by two-dimensional electrophoresis, reverse-transcriptase polymerase chain reaction, Western blot, immunofluorescence, and co-immunoprecipitation assays.	arsenite	166-174	heat shock protein family A (Hsp70) member 9	Homo sapiens	115-120
20199942-4	2010	We determined the levels and functions of p53, nuclear factor-kappa B (NF-B; a key transcriptional regulator), and mot-2 (a p53 inhibitor) and their relationships in arsenite-induced transformed HELF cells by two-dimensional electrophoresis, reverse-transcriptase polymerase chain reaction, Western blot, immunofluorescence, and co-immunoprecipitation assays.	arsenite	166-174	tumor protein p53	Homo sapiens	124-127
20199942-13	2010	CONCLUSIONS: mot-2-mediated cross talk between NF-B and p53 appears to be involved in arsenite-induced tumorigenesis of HELF cells.	arsenite	86-94	heat shock protein family A (Hsp70) member 9	Homo sapiens	13-18
20199942-13	2010	CONCLUSIONS: mot-2-mediated cross talk between NF-B and p53 appears to be involved in arsenite-induced tumorigenesis of HELF cells.	arsenite	86-94	tumor protein p53	Homo sapiens	56-59
20382397-1	2010	A modified mirror reaction was developed to prepare a sensitive and reproducible Ag nanofilm substrate for the surface-enhanced Raman scattering (SERS) analysis of arsenate (As(V)) and arsenite (As(III)).	arsenite	185-193	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	146-150
20632810-9	2010	Activation of the Hog1 MAP kinase in response to osmotic stress or arsenite leads to the transient arrest of the cell cycle in G1 phase, which is mediated by direct phosphorylation of the CDK inhibitor, Sic1, and by downregulation of cyclin expression.	arsenite	67-75	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	18-22
20632810-9	2010	Activation of the Hog1 MAP kinase in response to osmotic stress or arsenite leads to the transient arrest of the cell cycle in G1 phase, which is mediated by direct phosphorylation of the CDK inhibitor, Sic1, and by downregulation of cyclin expression.	arsenite	67-75	cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1	Saccharomyces cerevisiae S288C	203-207
20488895-8	2010	Moreover, both the ptlpd1 and ptlpd2 mutants were more sensitive to arsenite than wild-type plants, and the LPD activity in isolated chloroplasts from wild-type plants was sensitive to arsenite but not arsenate.	arsenite	185-193	lipoamide dehydrogenase 1	Arabidopsis thaliana	19-25
20375080-0	2010	The repressive effect of NF-kappaB on p53 by mot-2 is involved in human keratinocyte transformation induced by low levels of arsenite.	arsenite	125-133	nuclear factor kappa B subunit 1	Homo sapiens	25-34
20423714-0	2010	Severe systemic toxicity and urinary bladder cytotoxicity and regenerative hyperplasia induced by arsenite in arsenic (+3 oxidation state) methyltransferase knockout mice.	arsenite	98-106	arsenite methyltransferase	Mus musculus	110-156
20375080-10	2010	Together, the results suggest that the repressive effect of NF-kappaB on p53 by mot-2 leads to genomic instability, which is involved in arsenite-induced malignant transformation of human keratinocytes.	arsenite	137-145	nuclear factor kappa B subunit 1	Homo sapiens	60-69
20375080-0	2010	The repressive effect of NF-kappaB on p53 by mot-2 is involved in human keratinocyte transformation induced by low levels of arsenite.	arsenite	125-133	tumor protein p53	Homo sapiens	38-41
20375080-10	2010	Together, the results suggest that the repressive effect of NF-kappaB on p53 by mot-2 leads to genomic instability, which is involved in arsenite-induced malignant transformation of human keratinocytes.	arsenite	137-145	tumor protein p53	Homo sapiens	73-76
20375080-0	2010	The repressive effect of NF-kappaB on p53 by mot-2 is involved in human keratinocyte transformation induced by low levels of arsenite.	arsenite	125-133	heat shock protein family A (Hsp70) member 9	Homo sapiens	45-50
20375080-10	2010	Together, the results suggest that the repressive effect of NF-kappaB on p53 by mot-2 leads to genomic instability, which is involved in arsenite-induced malignant transformation of human keratinocytes.	arsenite	137-145	heat shock protein family A (Hsp70) member 9	Homo sapiens	80-85
20375080-5	2010	In arsenite-exposed cells, the levels of phospho-p53, p21, and mdm2 increase at early times after exposure.	arsenite	3-11	tumor protein p53	Homo sapiens	49-52
20375080-5	2010	In arsenite-exposed cells, the levels of phospho-p53, p21, and mdm2 increase at early times after exposure.	arsenite	3-11	H3 histone pseudogene 16	Homo sapiens	54-57
20375080-5	2010	In arsenite-exposed cells, the levels of phospho-p53, p21, and mdm2 increase at early times after exposure.	arsenite	3-11	MDM2 proto-oncogene	Homo sapiens	63-67
20375080-8	2010	Blockage of NF-kappaB prevents the increases of arsenite-induced mot-2 levels, and knockdown of mot-2 facilitates the nuclear translocation of p53, indicating that, in HaCaT cells exposed to arsenite, NF-kappaB inhibits p53 function by mot-2.	arsenite	48-56	heat shock protein family A (Hsp70) member 9	Homo sapiens	65-70
20375080-8	2010	Blockage of NF-kappaB prevents the increases of arsenite-induced mot-2 levels, and knockdown of mot-2 facilitates the nuclear translocation of p53, indicating that, in HaCaT cells exposed to arsenite, NF-kappaB inhibits p53 function by mot-2.	arsenite	191-199	nuclear factor kappa B subunit 1	Homo sapiens	12-21
20375080-8	2010	Blockage of NF-kappaB prevents the increases of arsenite-induced mot-2 levels, and knockdown of mot-2 facilitates the nuclear translocation of p53, indicating that, in HaCaT cells exposed to arsenite, NF-kappaB inhibits p53 function by mot-2.	arsenite	191-199	heat shock protein family A (Hsp70) member 9	Homo sapiens	96-101
20375080-8	2010	Blockage of NF-kappaB prevents the increases of arsenite-induced mot-2 levels, and knockdown of mot-2 facilitates the nuclear translocation of p53, indicating that, in HaCaT cells exposed to arsenite, NF-kappaB inhibits p53 function by mot-2.	arsenite	191-199	tumor protein p53	Homo sapiens	143-146
20375080-8	2010	Blockage of NF-kappaB prevents the increases of arsenite-induced mot-2 levels, and knockdown of mot-2 facilitates the nuclear translocation of p53, indicating that, in HaCaT cells exposed to arsenite, NF-kappaB inhibits p53 function by mot-2.	arsenite	191-199	nuclear factor kappa B subunit 1	Homo sapiens	201-210
20375080-8	2010	Blockage of NF-kappaB prevents the increases of arsenite-induced mot-2 levels, and knockdown of mot-2 facilitates the nuclear translocation of p53, indicating that, in HaCaT cells exposed to arsenite, NF-kappaB inhibits p53 function by mot-2.	arsenite	191-199	tumor protein p53	Homo sapiens	220-223
20375080-8	2010	Blockage of NF-kappaB prevents the increases of arsenite-induced mot-2 levels, and knockdown of mot-2 facilitates the nuclear translocation of p53, indicating that, in HaCaT cells exposed to arsenite, NF-kappaB inhibits p53 function by mot-2.	arsenite	191-199	heat shock protein family A (Hsp70) member 9	Homo sapiens	96-101
20375080-9	2010	Moreover, inactivation of NF-kappaB facilitated p53-mediated DNA repair and prevented arsenite-induced malignant transformation.	arsenite	86-94	nuclear factor kappa B subunit 1	Homo sapiens	26-35
20420878-9	2010	Activation and nuclear localization of p52 and Bcl3 in response to low concentration arsenite indicated that the non-canonical NF-kappaB pathway was involved in arsenite-induced cyclin D1 expression.	arsenite	161-169	cyclin D1	Homo sapiens	178-187
20420878-11	2010	The up-regulation of cyclin D1 mediated by the p52-Bcl3 complex in response to low concentration arsenite might be important in assessing the health risk of low concentration arsenite and understanding the mechanisms of the harmful effects of arsenite.	arsenite	97-105	cyclin D1	Homo sapiens	21-30
20420878-0	2010	p52-Bcl3 complex promotes cyclin D1 expression in BEAS-2B cells in response to low concentration arsenite.	arsenite	97-105	nuclear factor kappa B subunit 2	Homo sapiens	0-3
20420878-11	2010	The up-regulation of cyclin D1 mediated by the p52-Bcl3 complex in response to low concentration arsenite might be important in assessing the health risk of low concentration arsenite and understanding the mechanisms of the harmful effects of arsenite.	arsenite	97-105	nuclear factor kappa B subunit 2	Homo sapiens	47-50
20420878-11	2010	The up-regulation of cyclin D1 mediated by the p52-Bcl3 complex in response to low concentration arsenite might be important in assessing the health risk of low concentration arsenite and understanding the mechanisms of the harmful effects of arsenite.	arsenite	97-105	BCL3 transcription coactivator	Homo sapiens	51-55
20420878-0	2010	p52-Bcl3 complex promotes cyclin D1 expression in BEAS-2B cells in response to low concentration arsenite.	arsenite	97-105	BCL3 transcription coactivator	Homo sapiens	4-8
20420878-0	2010	p52-Bcl3 complex promotes cyclin D1 expression in BEAS-2B cells in response to low concentration arsenite.	arsenite	97-105	cyclin D1	Homo sapiens	26-35
20420878-11	2010	The up-regulation of cyclin D1 mediated by the p52-Bcl3 complex in response to low concentration arsenite might be important in assessing the health risk of low concentration arsenite and understanding the mechanisms of the harmful effects of arsenite.	arsenite	175-183	cyclin D1	Homo sapiens	21-30
20420878-3	2010	It is also known that arsenite exposure enhances cyclin D1 expression, which involves NF-kappaB activation.	arsenite	22-30	cyclin D1	Homo sapiens	49-58
20420878-11	2010	The up-regulation of cyclin D1 mediated by the p52-Bcl3 complex in response to low concentration arsenite might be important in assessing the health risk of low concentration arsenite and understanding the mechanisms of the harmful effects of arsenite.	arsenite	175-183	nuclear factor kappa B subunit 2	Homo sapiens	47-50
20420878-7	2010	To profile the canonical and non-canonical NF-kappaB pathways involved in cell growth and cyclin D1 expression induced by low concentration arsenite, the NF-kappaB-specific inhibitor-phenethyl caffeate (CAPE) and NF-kappaB2 mRNA target sequences were used, and cyclin D1 expression in BEAS-2B cells was assessed.	arsenite	140-148	cyclin D1	Homo sapiens	90-99
20420878-7	2010	To profile the canonical and non-canonical NF-kappaB pathways involved in cell growth and cyclin D1 expression induced by low concentration arsenite, the NF-kappaB-specific inhibitor-phenethyl caffeate (CAPE) and NF-kappaB2 mRNA target sequences were used, and cyclin D1 expression in BEAS-2B cells was assessed.	arsenite	140-148	cyclin D1	Homo sapiens	261-270
20420878-11	2010	The up-regulation of cyclin D1 mediated by the p52-Bcl3 complex in response to low concentration arsenite might be important in assessing the health risk of low concentration arsenite and understanding the mechanisms of the harmful effects of arsenite.	arsenite	175-183	BCL3 transcription coactivator	Homo sapiens	51-55
20420878-8	2010	Our results demonstrated that exposure to low concentration arsenite enhanced BEAS-2B cells growth and cyclin D1 mRNA and protein expression.	arsenite	60-68	cyclin D1	Homo sapiens	103-112
20420878-11	2010	The up-regulation of cyclin D1 mediated by the p52-Bcl3 complex in response to low concentration arsenite might be important in assessing the health risk of low concentration arsenite and understanding the mechanisms of the harmful effects of arsenite.	arsenite	175-183	cyclin D1	Homo sapiens	21-30
20420878-9	2010	Activation and nuclear localization of p52 and Bcl3 in response to low concentration arsenite indicated that the non-canonical NF-kappaB pathway was involved in arsenite-induced cyclin D1 expression.	arsenite	85-93	nuclear factor kappa B subunit 2	Homo sapiens	39-42
20420878-9	2010	Activation and nuclear localization of p52 and Bcl3 in response to low concentration arsenite indicated that the non-canonical NF-kappaB pathway was involved in arsenite-induced cyclin D1 expression.	arsenite	85-93	BCL3 transcription coactivator	Homo sapiens	47-51
20420878-11	2010	The up-regulation of cyclin D1 mediated by the p52-Bcl3 complex in response to low concentration arsenite might be important in assessing the health risk of low concentration arsenite and understanding the mechanisms of the harmful effects of arsenite.	arsenite	175-183	nuclear factor kappa B subunit 2	Homo sapiens	47-50
20420878-9	2010	Activation and nuclear localization of p52 and Bcl3 in response to low concentration arsenite indicated that the non-canonical NF-kappaB pathway was involved in arsenite-induced cyclin D1 expression.	arsenite	85-93	cyclin D1	Homo sapiens	178-187
20420878-11	2010	The up-regulation of cyclin D1 mediated by the p52-Bcl3 complex in response to low concentration arsenite might be important in assessing the health risk of low concentration arsenite and understanding the mechanisms of the harmful effects of arsenite.	arsenite	175-183	BCL3 transcription coactivator	Homo sapiens	51-55
20420878-9	2010	Activation and nuclear localization of p52 and Bcl3 in response to low concentration arsenite indicated that the non-canonical NF-kappaB pathway was involved in arsenite-induced cyclin D1 expression.	arsenite	161-169	nuclear factor kappa B subunit 2	Homo sapiens	39-42
20420878-9	2010	Activation and nuclear localization of p52 and Bcl3 in response to low concentration arsenite indicated that the non-canonical NF-kappaB pathway was involved in arsenite-induced cyclin D1 expression.	arsenite	161-169	BCL3 transcription coactivator	Homo sapiens	47-51
20633106-11	2010	Moreover, expression of heme oxygenase-1, alpha-synuclein aggregation, and DNA fragmentation were significantly enhanced in SN co-infused with low doses of arsenite and iron.	arsenite	156-164	heme oxygenase 1	Rattus norvegicus	24-40
20633106-11	2010	Moreover, expression of heme oxygenase-1, alpha-synuclein aggregation, and DNA fragmentation were significantly enhanced in SN co-infused with low doses of arsenite and iron.	arsenite	156-164	synuclein alpha	Rattus norvegicus	42-57
20678253-0	2010	Inhibition of poly (ADP-Ribose) polymerase-1 in telomerase deficient mouse embryonic fibroblasts increases arsenite-induced genome instability.	arsenite	107-115	poly (ADP-ribose) polymerase family, member 1	Mus musculus	14-44
20519851-1	2010	Our previous study indicated that Nrf2 is a key transcription factor in cellular defenses against inorganic arsenite (iAsIII).	arsenite	108-116	NFE2 like bZIP transcription factor 2	Homo sapiens	34-38
20423156-0	2010	Caenorhabditis elegans bicarbonate transporter ABTS-1 is involved in arsenite toxicity and cholinergic signaling.	arsenite	69-77	Anion exchange protein	Caenorhabditis elegans	47-53
20423156-4	2010	We found that abts-1, which encodes a Na(+)-dependent Cl(-)/HCO(3)(-) transporter, is required to protect C. elegans from arsenite toxicity.	arsenite	122-130	Anion exchange protein	Caenorhabditis elegans	14-20
20423156-5	2010	The abts-1::GFP transgene is primarily expressed in neurons and the hypodermis, but stronger expression was also observed in the pharynx and body wall muscle cells after exposure to arsenite.	arsenite	182-190	Anion exchange protein	Caenorhabditis elegans	4-10
20423156-6	2010	The steady-state level of ABTS-1 mRNA increased in response to arsenite exposure.	arsenite	63-71	Anion exchange protein	Caenorhabditis elegans	26-32
20423156-8	2010	We also showed that arsenite enhanced sensitivity to aldicarb and levamisole in abts-1 mutant worms.	arsenite	20-28	Anion exchange protein	Caenorhabditis elegans	80-86
20188822-0	2010	Arsenite down-regulates cytochrome P450 1A1 at the transcriptional and posttranslational levels in human HepG2 cells.	arsenite	0-8	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	24-43
20188822-1	2010	Aryl hydrocarbon receptor (AhR) ligands, typified by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and metals, typified by arsenite (As(III)), are environmental cocontaminants, and their molecular interaction may disrupt the coordinated regulation of the carcinogen activating enzyme cytochrome P450 1A1 (CYP1A1).	arsenite	121-129	aryl hydrocarbon receptor	Homo sapiens	0-25
20188822-1	2010	Aryl hydrocarbon receptor (AhR) ligands, typified by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and metals, typified by arsenite (As(III)), are environmental cocontaminants, and their molecular interaction may disrupt the coordinated regulation of the carcinogen activating enzyme cytochrome P450 1A1 (CYP1A1).	arsenite	121-129	aryl hydrocarbon receptor	Homo sapiens	27-30
20188822-1	2010	Aryl hydrocarbon receptor (AhR) ligands, typified by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and metals, typified by arsenite (As(III)), are environmental cocontaminants, and their molecular interaction may disrupt the coordinated regulation of the carcinogen activating enzyme cytochrome P450 1A1 (CYP1A1).	arsenite	121-129	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	282-301
20188822-1	2010	Aryl hydrocarbon receptor (AhR) ligands, typified by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and metals, typified by arsenite (As(III)), are environmental cocontaminants, and their molecular interaction may disrupt the coordinated regulation of the carcinogen activating enzyme cytochrome P450 1A1 (CYP1A1).	arsenite	121-129	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	303-309
20377179-0	2010	Protective effect of quercetin against arsenite-induced COX-2 expression by targeting PI3K in rat liver epithelial cells.	arsenite	39-47	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	56-61
20377179-3	2010	The present study demonstrates that COX-2 expression and PGE(2) secretion are up-regulated by arsenite in rat liver epithelial (RLE) cells.	arsenite	94-102	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	36-41
20377179-4	2010	The possible inhibitory effect of quercetin, a naturally occurring dietary flavonol, on arsenite-induced COX-2 expression and PGE(2) production was investigated.	arsenite	88-96	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	105-110
20377179-5	2010	Pretreatment with quercetin resulted in the reduction of arsenite-induced expression of COX-2 and production of PGE(2).	arsenite	57-65	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	88-93
20377179-6	2010	The arsenite-induced phosphorylation of Akt, p70S6K, and extracellular signal-regulated protein kinases (ERKs), but not p38, was inhibited by quercetin treatment.	arsenite	4-12	AKT serine/threonine kinase 1	Rattus norvegicus	40-43
20377179-6	2010	The arsenite-induced phosphorylation of Akt, p70S6K, and extracellular signal-regulated protein kinases (ERKs), but not p38, was inhibited by quercetin treatment.	arsenite	4-12	ribosomal protein S6 kinase B1	Rattus norvegicus	45-51
20377179-7	2010	An ex vivo kinase assay revealed that quercetin suppressed arsenite-induced phosphoinositide 3-kinase (PI3K) activity upstream of Akt in RLE cell lysates.	arsenite	59-67	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	76-101
20377179-7	2010	An ex vivo kinase assay revealed that quercetin suppressed arsenite-induced phosphoinositide 3-kinase (PI3K) activity upstream of Akt in RLE cell lysates.	arsenite	59-67	AKT serine/threonine kinase 1	Rattus norvegicus	130-133
20100676-7	2010	Consistent with our hypothesis, a significantly enhanced Nrf2 activity, determined by its nuclear accumulation and induction of its target genes, was observed in arsenite-exposed cells.	arsenite	162-170	NFE2 like bZIP transcription factor 2	Homo sapiens	57-61
20100676-8	2010	In keeping with the activation of Nrf2-mediated antioxidant response, intracellular glutathione and intracellular hydrogen peroxide-scavenging activity was dose dependently increased by arsenite exposure.	arsenite	186-194	NFE2 like bZIP transcription factor 2	Homo sapiens	34-38
20530755-3	2010	Here, we describe the isolation and characterization of two P. vittata genes, ACR3 and ACR3;1, which encode proteins similar to the ACR3 arsenite effluxer of yeast.	arsenite	137-145	Arr3p	Saccharomyces cerevisiae S288C	78-82
20530755-3	2010	Here, we describe the isolation and characterization of two P. vittata genes, ACR3 and ACR3;1, which encode proteins similar to the ACR3 arsenite effluxer of yeast.	arsenite	137-145	Arr3p	Saccharomyces cerevisiae S288C	87-91
20530755-3	2010	Here, we describe the isolation and characterization of two P. vittata genes, ACR3 and ACR3;1, which encode proteins similar to the ACR3 arsenite effluxer of yeast.	arsenite	137-145	Arr3p	Saccharomyces cerevisiae S288C	87-91
20530755-6	2010	Knocking down the expression of ACR3, but not ACR3;1, in the gametophyte results in an arsenite-sensitive phenotype, indicating that ACR3 plays a necessary role in arsenic tolerance in the gametophyte.	arsenite	87-95	Arr3p	Saccharomyces cerevisiae S288C	32-36
20530755-7	2010	We show that ACR3 localizes to the vacuolar membrane in gametophytes, indicating that it likely effluxes arsenite into the vacuole for sequestration.	arsenite	105-113	Arr3p	Saccharomyces cerevisiae S288C	13-17
20377179-9	2010	Moreover, LY294002 (a PI3K inhibitor) significantly attenuated COX-2 expression and PGE(2) production in arsenite-treated RLE cells.	arsenite	105-113	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	63-68
20377179-10	2010	These results suggest that quercetin suppresses arsenite-induced COX-2 expression mainly by blocking the activation of the PI3K signaling pathway, which may contribute to its chemopreventive potential.	arsenite	48-56	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	65-70
20678253-6	2010	RESULTS: Inhibition of PARP in telomerase deficient MEFs induced an increase in arsenite-induced DNA damage as compared to control cells.	arsenite	80-88	poly (ADP-ribose) polymerase family, member 1	Mus musculus	23-27
20302512-4	2010	Arsenite treatment induced autophagosome formation and permeabilization of mitochondria, followed by caspase 3/7-mediated apoptosis.	arsenite	0-8	caspase 3	Homo sapiens	101-110
20138231-9	2010	The availability of amphibian cultured cells has enabled the analysis of hsp gene expression induced by different stresses (e.g. cadmium, arsenite, proteasome inhibitors etc.	arsenite	138-146	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	73-76
20083128-8	2010	Arsenite induced HO-1 mRNA and protein expression.	arsenite	0-8	heme oxygenase 1	Homo sapiens	17-21
20412057-4	2010	The ROQ domain is necessary and sufficient for localization to arsenite-induced stress granules and to induce these structures upon overexpression, and is required to trigger Icos mRNA decay.	arsenite	63-71	inducible T cell costimulator	Homo sapiens	175-179
20129672-0	2010	Transition metal ions and selenite modulate the methylation of arsenite by the recombinant human arsenic (+3 oxidation state) methyltransferase (hAS3MT).	arsenite	63-71	arsenite methyltransferase	Homo sapiens	97-143
20129672-0	2010	Transition metal ions and selenite modulate the methylation of arsenite by the recombinant human arsenic (+3 oxidation state) methyltransferase (hAS3MT).	arsenite	63-71	arsenite methyltransferase	Homo sapiens	145-151
20129672-1	2010	This report demonstrates that transition metal ions and selenite affect the arsenite methylation by the recombinant human arsenic (+3 oxidation state) methyltransferase (hAS3MT) in vitro.	arsenite	76-84	arsenite methyltransferase	Homo sapiens	122-168
20129672-1	2010	This report demonstrates that transition metal ions and selenite affect the arsenite methylation by the recombinant human arsenic (+3 oxidation state) methyltransferase (hAS3MT) in vitro.	arsenite	76-84	arsenite methyltransferase	Homo sapiens	170-176
20129672-2	2010	Co(2+), Mn(2+), and Zn(2+) inhibited the arsenite methylation by hAS3MT in a concentration-dependent manner and the kinetics indicated Co(2+) and Mn(2+) to be mixed (competitive and non-competitive) inhibitors while Zn(2+) to be a competitive inhibitor.	arsenite	41-49	arsenite methyltransferase	Homo sapiens	65-71
20129672-6	2010	The inhibition of arsenite methylating activity of hAS3MT by selenite was reversed by 2mM DTT (dithiothreitol) but neither by cysteine nor by beta-mercaptoethanol.	arsenite	18-26	PDS5 cohesin associated factor B	Homo sapiens	51-55
20083128-9	2010	Knock down of HO-1 expression decreased arsenite-induced VEGF expression, cell migration, and tube formation.	arsenite	40-48	heme oxygenase 1	Homo sapiens	14-18
20083128-9	2010	Knock down of HO-1 expression decreased arsenite-induced VEGF expression, cell migration, and tube formation.	arsenite	40-48	vascular endothelial growth factor A	Homo sapiens	57-61
20083128-10	2010	We showed that arsenite promoted dissociation of Bach1 (a transcriptional repressor) from the HO-1 enhancers and increased Nrf2 binding to these elements.	arsenite	15-23	BTB domain and CNC homolog 1	Homo sapiens	49-54
20083128-10	2010	We showed that arsenite promoted dissociation of Bach1 (a transcriptional repressor) from the HO-1 enhancers and increased Nrf2 binding to these elements.	arsenite	15-23	heme oxygenase 1	Homo sapiens	94-98
20083128-10	2010	We showed that arsenite promoted dissociation of Bach1 (a transcriptional repressor) from the HO-1 enhancers and increased Nrf2 binding to these elements.	arsenite	15-23	NFE2 like bZIP transcription factor 2	Homo sapiens	123-127
20083128-11	2010	Site directed mutagenesis assay identified that Bach1 cysteine residues 557 and 574 were essential for the induction of HO-1 gene in response to arsenite.	arsenite	145-153	BTB domain and CNC homolog 1	Homo sapiens	48-53
20083128-11	2010	Site directed mutagenesis assay identified that Bach1 cysteine residues 557 and 574 were essential for the induction of HO-1 gene in response to arsenite.	arsenite	145-153	heme oxygenase 1	Homo sapiens	120-124
20083128-12	2010	These findings demonstrate a role for HO-1 in arsenite-mediated angiogenesis in vitro.	arsenite	46-54	heme oxygenase 1	Homo sapiens	38-42
20083129-0	2010	Arsenite induces apoptosis in human mesenchymal stem cells by altering Bcl-2 family proteins and by activating intrinsic pathway.	arsenite	0-8	BCL2 apoptosis regulator	Homo sapiens	71-76
20376341-2	2010	We have identified ornithine decarboxylase (ODC), an enzyme required for polyamine synthesis, and eIF5A, a polyamine (hypusine)-modified translation factor, as proteins required for arsenite-induced SG assembly.	arsenite	182-190	ornithine decarboxylase 1	Homo sapiens	19-42
20186883-0	2010	GADD45alpha mediates arsenite-induced cell apoptotic effect in human hepatoma cells via JNKs/AP-1-dependent pathway.	arsenite	21-29	growth arrest and DNA damage inducible alpha	Homo sapiens	0-11
20186883-3	2010	In this study, we have disclosed that arsenite effectively induces the apoptotic response in the HepG2 human hepatoma cells by triggering GADD45alpha induction and the subsequent activation of JNKs/AP-1 cell death pathway.	arsenite	38-46	growth arrest and DNA damage inducible alpha	Homo sapiens	138-149
20186883-4	2010	However, signaling events relating to GADD45alpha/JNKs/AP-1 pathway activation have not been observed in HL7702 human diploid hepatic cells under the same arsenite exposure condition.	arsenite	155-163	growth arrest and DNA damage inducible alpha	Homo sapiens	38-49
20186883-5	2010	Our results thus have illustrated the selective pro-apoptotic role of arsenite in the hepatoma cells by activating GADD45alpha-dependent cell death pathway whereas with little effect on the normal hepatic cells.	arsenite	70-78	growth arrest and DNA damage inducible alpha	Homo sapiens	115-126
20186883-6	2010	The approaches to up-regulate GADD45alpha levels might be helpful in improving the chemotherapeutic action of arsenite on certain solid tumors including hepatoma.	arsenite	110-118	growth arrest and DNA damage inducible alpha	Homo sapiens	30-41
20154146-2	2010	We identified the human OGFOD1 protein as a novel stress granule component that regulates the phosphorylation of eIF2alpha and the resumption of translation in cells recovering from arsenite-induced stress.	arsenite	182-190	2-oxoglutarate and iron dependent oxygenase domain containing 1	Homo sapiens	24-30
20154146-2	2010	We identified the human OGFOD1 protein as a novel stress granule component that regulates the phosphorylation of eIF2alpha and the resumption of translation in cells recovering from arsenite-induced stress.	arsenite	182-190	eukaryotic translation initiation factor 2A	Homo sapiens	113-122
20154146-4	2010	Overexpression of OGFOD1 led to increased abundance of phosphorylated eIF2alpha, both in unstressed cells and in cells exposed to arsenite-induced stress, and to accelerated apoptosis during stress.	arsenite	130-138	2-oxoglutarate and iron dependent oxygenase domain containing 1	Homo sapiens	18-24
20154146-4	2010	Overexpression of OGFOD1 led to increased abundance of phosphorylated eIF2alpha, both in unstressed cells and in cells exposed to arsenite-induced stress, and to accelerated apoptosis during stress.	arsenite	130-138	eukaryotic translation initiation factor 2A	Homo sapiens	70-79
20154146-7	2010	These findings argue that OGFOD1 plays important proapoptotic roles in the regulation of translation and HRI-mediated phosphorylation of eIF2alpha in cells subjected to arsenite-induced stress.	arsenite	169-177	2-oxoglutarate and iron dependent oxygenase domain containing 1	Homo sapiens	26-32
20154146-7	2010	These findings argue that OGFOD1 plays important proapoptotic roles in the regulation of translation and HRI-mediated phosphorylation of eIF2alpha in cells subjected to arsenite-induced stress.	arsenite	169-177	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	105-108
20154146-7	2010	These findings argue that OGFOD1 plays important proapoptotic roles in the regulation of translation and HRI-mediated phosphorylation of eIF2alpha in cells subjected to arsenite-induced stress.	arsenite	169-177	eukaryotic translation initiation factor 2A	Homo sapiens	137-146
20129916-2	2010	Here we show that ANG inhibits protein synthesis and promotes arsenite- and pateamine A-induced assembly of stress granules (SGs).	arsenite	62-70	angiogenin	Homo sapiens	18-21
20082316-0	2010	Opposing actions of insulin and arsenite converge on PKCdelta to alter keratinocyte proliferative potential and differentiation.	arsenite	32-40	protein kinase C delta	Homo sapiens	53-61
20082316-3	2010	In present work, we show that insulin signaling, probably through the IGF-I receptor, is required for the increase in cell size accompanying differentiation and that this is opposed by arsenite.	arsenite	185-193	insulin	Homo sapiens	30-37
20082316-3	2010	In present work, we show that insulin signaling, probably through the IGF-I receptor, is required for the increase in cell size accompanying differentiation and that this is opposed by arsenite.	arsenite	185-193	insulin like growth factor 1 receptor	Homo sapiens	70-84
20082316-4	2010	We further examine the impact of insulin and arsenite on PKCdelta, a known key regulator of keratinocyte differentiation, and show that insulin increases the amount, tyrosine phosphorylation, and membrane localization of PKCdelta.	arsenite	45-53	protein kinase C delta	Homo sapiens	57-65
20082316-4	2010	We further examine the impact of insulin and arsenite on PKCdelta, a known key regulator of keratinocyte differentiation, and show that insulin increases the amount, tyrosine phosphorylation, and membrane localization of PKCdelta.	arsenite	45-53	insulin	Homo sapiens	136-143
20082316-4	2010	We further examine the impact of insulin and arsenite on PKCdelta, a known key regulator of keratinocyte differentiation, and show that insulin increases the amount, tyrosine phosphorylation, and membrane localization of PKCdelta.	arsenite	45-53	protein kinase C delta	Homo sapiens	221-229
20082316-5	2010	All these effects are prevented by exposure of cells to arsenite or to inhibitors of downstream effectors of insulin (phosphotidylinositol 3-kinase and mammalian target of rapamycin).	arsenite	56-64	insulin	Homo sapiens	109-116
20082316-5	2010	All these effects are prevented by exposure of cells to arsenite or to inhibitors of downstream effectors of insulin (phosphotidylinositol 3-kinase and mammalian target of rapamycin).	arsenite	56-64	mechanistic target of rapamycin kinase	Homo sapiens	152-181
20082316-9	2010	Finally, inhibiting epidermal growth factor receptor kinase activity diminished the ability of arsenite to prevent cell enlargement and to suppress insulin-dependent PKCdelta amount and tyrosine 311 phosphorylation.	arsenite	95-103	insulin	Homo sapiens	148-155
20082316-9	2010	Finally, inhibiting epidermal growth factor receptor kinase activity diminished the ability of arsenite to prevent cell enlargement and to suppress insulin-dependent PKCdelta amount and tyrosine 311 phosphorylation.	arsenite	95-103	protein kinase C delta	Homo sapiens	166-174
20082316-10	2010	Thus suppression of PKCdelta signaling is a critical feature of arsenite action in preventing keratinocyte differentiation and maintaining proliferative capability.	arsenite	64-72	protein kinase C delta	Homo sapiens	20-28
20376341-2	2010	We have identified ornithine decarboxylase (ODC), an enzyme required for polyamine synthesis, and eIF5A, a polyamine (hypusine)-modified translation factor, as proteins required for arsenite-induced SG assembly.	arsenite	182-190	ornithine decarboxylase 1	Homo sapiens	44-47
20376341-2	2010	We have identified ornithine decarboxylase (ODC), an enzyme required for polyamine synthesis, and eIF5A, a polyamine (hypusine)-modified translation factor, as proteins required for arsenite-induced SG assembly.	arsenite	182-190	eukaryotic translation initiation factor 5A	Homo sapiens	98-103
20376341-3	2010	Knockdown of deoxyhypusine synthase (DHS) or treatment with a deoxyhypusine synthase inhibitor (GC7) prevents hypusine modification of eIF5A as well as arsenite-induced polysome disassembly and stress granule assembly.	arsenite	152-160	deoxyhypusine synthase	Homo sapiens	13-35
20376341-3	2010	Knockdown of deoxyhypusine synthase (DHS) or treatment with a deoxyhypusine synthase inhibitor (GC7) prevents hypusine modification of eIF5A as well as arsenite-induced polysome disassembly and stress granule assembly.	arsenite	152-160	deoxyhypusine synthase	Homo sapiens	62-84
20376341-6	2010	Our results reveal that hypusine-eIF5A-facilitated translation elongation promotes arsenite-induced polysome disassembly and stress granule assembly in cells subjected to adverse environmental conditions.	arsenite	83-91	eukaryotic translation initiation factor 5A	Homo sapiens	33-38
20006635-0	2010	Arsenite suppression of involucrin transcription through AP1 promoter sites in cultured human keratinocytes.	arsenite	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	57-60
20036271-10	2010	Our results suggest that arsenite"s interference with activation of P53 via poly(ADP-ribosyl)ation may play a role in the comutagenic and cocarcinogenic effects of arsenite.	arsenite	164-172	tumor protein p53	Homo sapiens	68-71
20006635-1	2010	While preserving keratinocyte proliferative ability, arsenite suppresses cellular differentiation markers by preventing utilization of AP1 transcriptional response elements.	arsenite	53-61	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	135-138
19932709-1	2010	Human arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite.	arsenite	101-109	arsenite methyltransferase	Homo sapiens	6-52
20006635-2	2010	In present experiments, arsenite had a dramatic effect in electrophoretic mobility supershift analysis of proteins binding to an involucrin promoter AP1 response element.	arsenite	24-32	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	149-152
19932709-1	2010	Human arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite.	arsenite	101-109	arsenite methyltransferase	Homo sapiens	54-59
20006635-4	2010	By contrast, band shift of nuclear extracts from arsenite treated cultures showed only JunB and Fra1 binding in postconfluent as well as preconfluent cultures.	arsenite	49-57	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	87-91
20006635-4	2010	By contrast, band shift of nuclear extracts from arsenite treated cultures showed only JunB and Fra1 binding in postconfluent as well as preconfluent cultures.	arsenite	49-57	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	96-100
20006635-5	2010	Immunoblotting of cell extracts showed that arsenite treatment prevented the loss of Fra1 and the increase in c-Fos proteins that occurred after confluence in untreated cultures.	arsenite	44-52	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	85-89
20006635-5	2010	Immunoblotting of cell extracts showed that arsenite treatment prevented the loss of Fra1 and the increase in c-Fos proteins that occurred after confluence in untreated cultures.	arsenite	44-52	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	110-115
20036271-0	2010	Arsenite induced poly(ADP-ribosyl)ation of tumor suppressor P53 in human skin keratinocytes as a possible mechanism for carcinogenesis associated with arsenic exposure.	arsenite	0-8	tumor protein p53	Homo sapiens	60-63
20036271-6	2010	This laboratory demonstrated earlier that in cells treated with arsenite, the P53-dependent increase in p21(WAF1/CIP1) expression, normally a block to cell cycle progression after DNA damage, is deficient.	arsenite	64-72	tumor protein p53	Homo sapiens	78-81
20036271-6	2010	This laboratory demonstrated earlier that in cells treated with arsenite, the P53-dependent increase in p21(WAF1/CIP1) expression, normally a block to cell cycle progression after DNA damage, is deficient.	arsenite	64-72	cyclin dependent kinase inhibitor 1A	Homo sapiens	104-107
20036271-6	2010	This laboratory demonstrated earlier that in cells treated with arsenite, the P53-dependent increase in p21(WAF1/CIP1) expression, normally a block to cell cycle progression after DNA damage, is deficient.	arsenite	64-72	cyclin dependent kinase inhibitor 1A	Homo sapiens	108-112
20036271-6	2010	This laboratory demonstrated earlier that in cells treated with arsenite, the P53-dependent increase in p21(WAF1/CIP1) expression, normally a block to cell cycle progression after DNA damage, is deficient.	arsenite	64-72	cyclin dependent kinase inhibitor 1A	Homo sapiens	113-117
20036271-7	2010	Here we show that although long-term exposure of human keratinocytes (HaCaT) to a nontoxic concentration (0.1 microM) of arsenite decreases the level of global protein poly(ADP-ribosyl)ation, it increases poly(ADP-ribosyl)ation of P53 protein and PARP-1 protein abundance.	arsenite	121-129	tumor protein p53	Homo sapiens	231-234
20036271-7	2010	Here we show that although long-term exposure of human keratinocytes (HaCaT) to a nontoxic concentration (0.1 microM) of arsenite decreases the level of global protein poly(ADP-ribosyl)ation, it increases poly(ADP-ribosyl)ation of P53 protein and PARP-1 protein abundance.	arsenite	121-129	poly(ADP-ribose) polymerase 1	Homo sapiens	247-253
20036271-8	2010	We also demonstrate that exposure to 0.1 microM arsenite depresses the constitutive expression of p21 mRNA and P21 protein in HaCaT cells.	arsenite	48-56	cyclin dependent kinase inhibitor 1A	Homo sapiens	98-101
20036271-8	2010	We also demonstrate that exposure to 0.1 microM arsenite depresses the constitutive expression of p21 mRNA and P21 protein in HaCaT cells.	arsenite	48-56	cyclin dependent kinase inhibitor 1A	Homo sapiens	111-114
20036271-10	2010	Our results suggest that arsenite"s interference with activation of P53 via poly(ADP-ribosyl)ation may play a role in the comutagenic and cocarcinogenic effects of arsenite.	arsenite	25-33	tumor protein p53	Homo sapiens	68-71
19931552-0	2010	Arsenite promotes centrosome abnormalities under a p53 compromised status induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).	arsenite	0-8	tumor protein p53	Homo sapiens	51-54
20179204-4	2010	Overexpression of the dominant negative mutant of HIF-1alpha (DN-HIF) significantly enhanced cyclin D1 expression upon hypoxia or arsenite exposure, suggesting the negative regulation of cyclin D1 by HIF-1.	arsenite	130-138	hypoxia inducible factor 1, alpha subunit	Mus musculus	50-60
20179204-4	2010	Overexpression of the dominant negative mutant of HIF-1alpha (DN-HIF) significantly enhanced cyclin D1 expression upon hypoxia or arsenite exposure, suggesting the negative regulation of cyclin D1 by HIF-1.	arsenite	130-138	cyclin D1	Mus musculus	93-102
20179204-4	2010	Overexpression of the dominant negative mutant of HIF-1alpha (DN-HIF) significantly enhanced cyclin D1 expression upon hypoxia or arsenite exposure, suggesting the negative regulation of cyclin D1 by HIF-1.	arsenite	130-138	cyclin D1	Mus musculus	187-196
20026328-1	2010	The stress-activated kinase Hog1p mediates arsenic tolerance by decreasing arsenite influx through the aquaglyceroporin Fps1p in Saccharomyces cerevisiae.	arsenite	75-83	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	28-33
20026328-1	2010	The stress-activated kinase Hog1p mediates arsenic tolerance by decreasing arsenite influx through the aquaglyceroporin Fps1p in Saccharomyces cerevisiae.	arsenite	75-83	Fps1p	Saccharomyces cerevisiae S288C	120-125
20026328-2	2010	Unexpectedly, we found that overexpression of FPS1 increased arsenite tolerance suggesting a physiological role of Fps1p in arsenic detoxification.	arsenite	61-69	Fps1p	Saccharomyces cerevisiae S288C	46-50
20026328-3	2010	Consistently, during arsenite treatment transcription of FPS1 gene was strongly upregulated, while Fps1p was not degraded and remained localized to the plasma membrane.	arsenite	21-29	Fps1p	Saccharomyces cerevisiae S288C	57-61
20026328-5	2010	Finally, transport experiments revealed that Fps1p in concert with the arsenite transporter Acr3p mediates arsenite efflux.	arsenite	71-79	Arr3p	Saccharomyces cerevisiae S288C	92-97
20000476-0	2010	Suppression of p53 and p21CIP1/WAF1 reduces arsenite-induced aneuploidy.	arsenite	44-52	tumor protein p53	Homo sapiens	15-18
20000476-0	2010	Suppression of p53 and p21CIP1/WAF1 reduces arsenite-induced aneuploidy.	arsenite	44-52	cyclin dependent kinase inhibitor 1A	Homo sapiens	23-30
20000476-0	2010	Suppression of p53 and p21CIP1/WAF1 reduces arsenite-induced aneuploidy.	arsenite	44-52	cyclin dependent kinase inhibitor 1A	Homo sapiens	31-35
20000476-7	2010	Although suppression of p53 increased the fraction of arsenite-treated cells with MN, it caused a decrease in the fraction with centromeric DNA.	arsenite	54-62	tumor protein p53	Homo sapiens	24-27
20000476-10	2010	Furthermore, our current results support this role for p21(CIP1/WAF1) since suppression of p21(CIP1/WAF1) caused a decrease in aneuploidy induced by arsenite, suggesting that p21(CIP1/WAF1) plays a role in mitotic exit.	arsenite	149-157	cyclin dependent kinase inhibitor 1A	Homo sapiens	55-58
20000476-10	2010	Furthermore, our current results support this role for p21(CIP1/WAF1) since suppression of p21(CIP1/WAF1) caused a decrease in aneuploidy induced by arsenite, suggesting that p21(CIP1/WAF1) plays a role in mitotic exit.	arsenite	149-157	cyclin dependent kinase inhibitor 1A	Homo sapiens	59-63
20000476-10	2010	Furthermore, our current results support this role for p21(CIP1/WAF1) since suppression of p21(CIP1/WAF1) caused a decrease in aneuploidy induced by arsenite, suggesting that p21(CIP1/WAF1) plays a role in mitotic exit.	arsenite	149-157	cyclin dependent kinase inhibitor 1A	Homo sapiens	64-68
20000476-10	2010	Furthermore, our current results support this role for p21(CIP1/WAF1) since suppression of p21(CIP1/WAF1) caused a decrease in aneuploidy induced by arsenite, suggesting that p21(CIP1/WAF1) plays a role in mitotic exit.	arsenite	149-157	cyclin dependent kinase inhibitor 1A	Homo sapiens	91-94
20000476-10	2010	Furthermore, our current results support this role for p21(CIP1/WAF1) since suppression of p21(CIP1/WAF1) caused a decrease in aneuploidy induced by arsenite, suggesting that p21(CIP1/WAF1) plays a role in mitotic exit.	arsenite	149-157	cyclin dependent kinase inhibitor 1A	Homo sapiens	95-99
20000476-10	2010	Furthermore, our current results support this role for p21(CIP1/WAF1) since suppression of p21(CIP1/WAF1) caused a decrease in aneuploidy induced by arsenite, suggesting that p21(CIP1/WAF1) plays a role in mitotic exit.	arsenite	149-157	cyclin dependent kinase inhibitor 1A	Homo sapiens	100-104
20000476-10	2010	Furthermore, our current results support this role for p21(CIP1/WAF1) since suppression of p21(CIP1/WAF1) caused a decrease in aneuploidy induced by arsenite, suggesting that p21(CIP1/WAF1) plays a role in mitotic exit.	arsenite	149-157	cyclin dependent kinase inhibitor 1A	Homo sapiens	91-94
20000476-10	2010	Furthermore, our current results support this role for p21(CIP1/WAF1) since suppression of p21(CIP1/WAF1) caused a decrease in aneuploidy induced by arsenite, suggesting that p21(CIP1/WAF1) plays a role in mitotic exit.	arsenite	149-157	cyclin dependent kinase inhibitor 1A	Homo sapiens	95-99
20000476-10	2010	Furthermore, our current results support this role for p21(CIP1/WAF1) since suppression of p21(CIP1/WAF1) caused a decrease in aneuploidy induced by arsenite, suggesting that p21(CIP1/WAF1) plays a role in mitotic exit.	arsenite	149-157	cyclin dependent kinase inhibitor 1A	Homo sapiens	100-104
20050688-6	2010	We further demonstrated that the arsenite-induced growth inhibition of HL-60 cells could be rescued by treatment with palmitate, the final product of fatty acid synthase, supporting that arsenite exerts its cytotoxic effect, in part, via suppressing the expression of fatty acid synthase and inhibiting the endogenous production of fatty acid.	arsenite	33-41	fatty acid synthase	Homo sapiens	150-169
20050688-6	2010	We further demonstrated that the arsenite-induced growth inhibition of HL-60 cells could be rescued by treatment with palmitate, the final product of fatty acid synthase, supporting that arsenite exerts its cytotoxic effect, in part, via suppressing the expression of fatty acid synthase and inhibiting the endogenous production of fatty acid.	arsenite	33-41	fatty acid synthase	Homo sapiens	268-287
20050688-6	2010	We further demonstrated that the arsenite-induced growth inhibition of HL-60 cells could be rescued by treatment with palmitate, the final product of fatty acid synthase, supporting that arsenite exerts its cytotoxic effect, in part, via suppressing the expression of fatty acid synthase and inhibiting the endogenous production of fatty acid.	arsenite	187-195	fatty acid synthase	Homo sapiens	150-169
20050688-6	2010	We further demonstrated that the arsenite-induced growth inhibition of HL-60 cells could be rescued by treatment with palmitate, the final product of fatty acid synthase, supporting that arsenite exerts its cytotoxic effect, in part, via suppressing the expression of fatty acid synthase and inhibiting the endogenous production of fatty acid.	arsenite	187-195	fatty acid synthase	Homo sapiens	268-287
19931552-7	2010	NNK treatment could also reduce arsenite-induced G2/M cell cycle arrest and apoptosis, these cellular effects were found to be correlated with p53 dysfunction.	arsenite	32-40	tumor protein p53	Homo sapiens	143-146
19931552-10	2010	Arsenite would act specifically on this p53 compromised status to induce centrosomal abnormality and colony formation.	arsenite	0-8	tumor protein p53	Homo sapiens	40-43
19933842-4	2010	Treatment of control cells with arsenite, an inducer of Nrf2 activity, increases their resistance to paraquat, hydrogen peroxide, cadmium, and UV light, rendering these cells as stress resistant as untreated cells from dwarf mice.	arsenite	32-40	nuclear factor, erythroid derived 2, like 2	Mus musculus	56-60
19802720-1	2010	Liver aquaglyceroporin AQP9 facilitates movement of trivalent inorganic arsenite (As(III)) and organic monomethylarsonous acid (MAs(III)).	arsenite	72-80	aquaporin 9	Homo sapiens	23-27
19918794-4	2010	Here we demonstrate that high-level arsenite induces severe redox imbalance by decreasing the levels of glutathione and increasing the levels of ROS through the oxidative stress adaptor p66Shc, which induces apoptosis by activating the cytochrome c-caspase.	arsenite	36-44	src homology 2 domain-containing transforming protein C1	Mus musculus	186-192
19918794-7	2010	In conclusion, we suggest that p66Shc-linked redox imbalance and abnormal extracellular amino acid metabolism mediate arsenite-induced embryonic retardation.	arsenite	118-126	src homology 2 domain-containing transforming protein C1	Mus musculus	31-37
20025242-8	2010	Our observations suggest that Cdc25B and -C may adventitiously reduce arsenate to the more toxic arsenite and may also provide a framework for identifying other human protein tyrosine phosphatases containing the active site Cys-X(5)-Arg loop that might moonlight as arsenate reductases.	arsenite	97-105	cell division cycle 25B	Homo sapiens	30-36
20008137-0	2010	The absence of interleukin-6 enhanced arsenite-induced renal injury by promoting autophagy of tubular epithelial cells with aberrant extracellular signal-regulated kinase activation.	arsenite	38-46	interleukin 6	Mus musculus	15-28
20043101-5	2010	In arsenite-treated cells, phosphorylation of EGFR, InsulinR and Flt3R showed an increase when compared to their non-arsenite treated counterparts.	arsenite	3-11	epidermal growth factor receptor	Homo sapiens	46-50
20043101-5	2010	In arsenite-treated cells, phosphorylation of EGFR, InsulinR and Flt3R showed an increase when compared to their non-arsenite treated counterparts.	arsenite	117-125	epidermal growth factor receptor	Homo sapiens	46-50
19836878-3	2010	The results showed that arsenite transformation occurred and was accompanied by the adsorption and fixation of both As(III) and As(V) on alpha-MnO(2).	arsenite	24-32	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	128-133
19836878-7	2010	The oxidation rate decreased and adsorbed As(III) and As(V) increased with increasing initial arsenite concentration.	arsenite	94-102	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	54-59
20008137-0	2010	The absence of interleukin-6 enhanced arsenite-induced renal injury by promoting autophagy of tubular epithelial cells with aberrant extracellular signal-regulated kinase activation.	arsenite	38-46	mitogen-activated protein kinase 1	Mus musculus	133-170
19766132-3	2009	Arsenite treatment (0-10 microM) for 4 h decreased MTHFR levels in a concentration-dependent fashion without significant effects on DHFR.	arsenite	0-8	methylenetetrahydrofolate reductase	Homo sapiens	51-56
20039738-5	2010	Even in the presence of the more toxic arsenic species, arsenite, cell metabolism was significantly impaired only at the highest arsenite concentration (500 muM) for one of the Fe(II)-oxidizers.	arsenite	56-64	latexin	Homo sapiens	157-160
20039738-5	2010	Even in the presence of the more toxic arsenic species, arsenite, cell metabolism was significantly impaired only at the highest arsenite concentration (500 muM) for one of the Fe(II)-oxidizers.	arsenite	129-137	latexin	Homo sapiens	157-160
20056578-9	2010	An early loss of NSC self-renewal gene expression (p63, ABCG2, BMI-1, SHH, OCT-4, NOTCH-1) during arsenite exposure was sub-sequently reversed as the tumor suppressor gene PTEN was progressively suppressed and the CSC-like phenotype acquired.	arsenite	98-106	tumor protein p63	Homo sapiens	51-54
20056578-9	2010	An early loss of NSC self-renewal gene expression (p63, ABCG2, BMI-1, SHH, OCT-4, NOTCH-1) during arsenite exposure was sub-sequently reversed as the tumor suppressor gene PTEN was progressively suppressed and the CSC-like phenotype acquired.	arsenite	98-106	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	56-61
20056578-9	2010	An early loss of NSC self-renewal gene expression (p63, ABCG2, BMI-1, SHH, OCT-4, NOTCH-1) during arsenite exposure was sub-sequently reversed as the tumor suppressor gene PTEN was progressively suppressed and the CSC-like phenotype acquired.	arsenite	98-106	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	63-68
20056578-9	2010	An early loss of NSC self-renewal gene expression (p63, ABCG2, BMI-1, SHH, OCT-4, NOTCH-1) during arsenite exposure was sub-sequently reversed as the tumor suppressor gene PTEN was progressively suppressed and the CSC-like phenotype acquired.	arsenite	98-106	sonic hedgehog signaling molecule	Homo sapiens	70-73
20056578-9	2010	An early loss of NSC self-renewal gene expression (p63, ABCG2, BMI-1, SHH, OCT-4, NOTCH-1) during arsenite exposure was sub-sequently reversed as the tumor suppressor gene PTEN was progressively suppressed and the CSC-like phenotype acquired.	arsenite	98-106	POU class 5 homeobox 1	Homo sapiens	75-80
20056578-9	2010	An early loss of NSC self-renewal gene expression (p63, ABCG2, BMI-1, SHH, OCT-4, NOTCH-1) during arsenite exposure was sub-sequently reversed as the tumor suppressor gene PTEN was progressively suppressed and the CSC-like phenotype acquired.	arsenite	98-106	notch receptor 1	Homo sapiens	82-89
20056578-9	2010	An early loss of NSC self-renewal gene expression (p63, ABCG2, BMI-1, SHH, OCT-4, NOTCH-1) during arsenite exposure was sub-sequently reversed as the tumor suppressor gene PTEN was progressively suppressed and the CSC-like phenotype acquired.	arsenite	98-106	phosphatase and tensin homolog	Homo sapiens	172-176
20020104-5	2010	Our results show that the retention of iAs and methylarsenic metabolites (MAs) by hepatocytes exposed to sub-micromolar concentrations of arsenite correlates negatively with MRP2 expression.	arsenite	138-146	ATP binding cassette subfamily C member 2	Homo sapiens	174-178
20020104-7	2010	After exposures to high micromolar concentrations of arsenite which almost completely inhibited MAs and DMAs production, a positive correlation was found between the expression of GLUT2 and cellular retention of iAs and MAs.	arsenite	53-61	solute carrier family 2 member 2	Homo sapiens	180-185
20020104-11	2010	The membrane transport of iAs by high-capacity GLUT2 transporters is not a rate-limiting step for the metabolism of arsenite at low exposure level, but may play a key role in accumulation of iAs after acute exposures which inhibit iAs methylation.	arsenite	116-124	solute carrier family 2 member 2	Homo sapiens	47-52
19910486-9	2010	In addition, cell treatment with arsenite results in recruitment of WDR62 to SG and activated JNK to processing bodies (PB).	arsenite	33-41	WD repeat domain 62	Homo sapiens	68-73
19910486-9	2010	In addition, cell treatment with arsenite results in recruitment of WDR62 to SG and activated JNK to processing bodies (PB).	arsenite	33-41	mitogen-activated protein kinase 8	Homo sapiens	94-97
19732783-3	2009	Previously, we reported that the SAS2 gene is required for optimal growth of yeast in the presence of arsenite (As(III)).	arsenite	102-110	histone acetyltransferase	Saccharomyces cerevisiae S288C	33-37
19766132-4	2009	The effects on MTHFR were observed at arsenite concentrations not significantly affecting cell viability.	arsenite	38-46	methylenetetrahydrofolate reductase	Homo sapiens	15-20
19766132-8	2009	Arsenite also induced dose-dependent increases in MT1/2 and c-Myc protein levels.	arsenite	0-8	metallothionein 1I, pseudogene	Homo sapiens	50-55
19766132-8	2009	Arsenite also induced dose-dependent increases in MT1/2 and c-Myc protein levels.	arsenite	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	60-65
19956799-5	2009	Accumulation of glycerol in the rgc1/2Delta mutant results from a defect in Fps1 activity as evidenced by suppression of the defect through Fps1 overexpression, failure to release glycerol upon hypo-osmotic shock, and resistance to arsenite, a toxic metalloid that enters the cell through Fps1.	arsenite	232-240	Rgc1p	Saccharomyces cerevisiae S288C	32-36
19956799-5	2009	Accumulation of glycerol in the rgc1/2Delta mutant results from a defect in Fps1 activity as evidenced by suppression of the defect through Fps1 overexpression, failure to release glycerol upon hypo-osmotic shock, and resistance to arsenite, a toxic metalloid that enters the cell through Fps1.	arsenite	232-240	Fps1p	Saccharomyces cerevisiae S288C	76-80
19577553-4	2009	Previously, we have demonstrated that arsenite can induce autophagy and death-associated protein kinase (DAPK) promoter hypermethylation in the SV-40 immortalized human uroepithelial cell line (SV-HUC-1).	arsenite	38-46	death associated protein kinase 1	Homo sapiens	72-103
19808956-0	2009	Tpl2 is a key mediator of arsenite-induced signal transduction.	arsenite	26-34	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	0-4
19808956-3	2009	However, the relevance of Tpl2 in arsenite-induced carcinogenesis and the underlying mechanisms remain to be explored.	arsenite	34-42	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	26-30
19808956-4	2009	We show that arsenite increased Tpl2 kinase activity and its phosphorylation in mouse epidermal JB6 P+ cells in a dose- and time-dependent manner.	arsenite	13-21	mitogen-activated protein kinase kinase kinase 8	Mus musculus	32-36
19808956-5	2009	Exposure to arsenite resulted in a marked induction of cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)), important mediators of inflammation and tumor promotion.	arsenite	12-20	prostaglandin-endoperoxide synthase 2	Homo sapiens	55-71
19808956-5	2009	Exposure to arsenite resulted in a marked induction of cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)), important mediators of inflammation and tumor promotion.	arsenite	12-20	prostaglandin-endoperoxide synthase 2	Homo sapiens	73-78
19808956-6	2009	Treatment with a Tpl2 kinase inhibitor or Tpl2 short hairpin RNA suppressed COX-2 expression and PGE(2) production induced by arsenite treatment, suggesting that Tpl2 is critical in arsenite-induced carcinogenesis.	arsenite	126-134	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	17-21
19808956-6	2009	Treatment with a Tpl2 kinase inhibitor or Tpl2 short hairpin RNA suppressed COX-2 expression and PGE(2) production induced by arsenite treatment, suggesting that Tpl2 is critical in arsenite-induced carcinogenesis.	arsenite	126-134	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	42-46
19808956-6	2009	Treatment with a Tpl2 kinase inhibitor or Tpl2 short hairpin RNA suppressed COX-2 expression and PGE(2) production induced by arsenite treatment, suggesting that Tpl2 is critical in arsenite-induced carcinogenesis.	arsenite	126-134	prostaglandin-endoperoxide synthase 2	Homo sapiens	76-81
19808956-6	2009	Treatment with a Tpl2 kinase inhibitor or Tpl2 short hairpin RNA suppressed COX-2 expression and PGE(2) production induced by arsenite treatment, suggesting that Tpl2 is critical in arsenite-induced carcinogenesis.	arsenite	126-134	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	42-46
19808956-6	2009	Treatment with a Tpl2 kinase inhibitor or Tpl2 short hairpin RNA suppressed COX-2 expression and PGE(2) production induced by arsenite treatment, suggesting that Tpl2 is critical in arsenite-induced carcinogenesis.	arsenite	182-190	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	42-46
19808956-6	2009	Treatment with a Tpl2 kinase inhibitor or Tpl2 short hairpin RNA suppressed COX-2 expression and PGE(2) production induced by arsenite treatment, suggesting that Tpl2 is critical in arsenite-induced carcinogenesis.	arsenite	182-190	prostaglandin-endoperoxide synthase 2	Homo sapiens	76-81
19808956-6	2009	Treatment with a Tpl2 kinase inhibitor or Tpl2 short hairpin RNA suppressed COX-2 expression and PGE(2) production induced by arsenite treatment, suggesting that Tpl2 is critical in arsenite-induced carcinogenesis.	arsenite	182-190	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	42-46
19808956-7	2009	We also found that arsenite-induced phosphorylation of extracellular signal-regulated kinases (ERK) or c-Jun NH(2)-terminal kinases (JNK) was markedly suppressed by Tpl2 kinase inhibitor or Tpl2 short hairpin RNA.	arsenite	19-27	mitogen-activated protein kinase 8	Homo sapiens	103-131
19808956-7	2009	We also found that arsenite-induced phosphorylation of extracellular signal-regulated kinases (ERK) or c-Jun NH(2)-terminal kinases (JNK) was markedly suppressed by Tpl2 kinase inhibitor or Tpl2 short hairpin RNA.	arsenite	19-27	mitogen-activated protein kinase 8	Homo sapiens	133-136
19808956-7	2009	We also found that arsenite-induced phosphorylation of extracellular signal-regulated kinases (ERK) or c-Jun NH(2)-terminal kinases (JNK) was markedly suppressed by Tpl2 kinase inhibitor or Tpl2 short hairpin RNA.	arsenite	19-27	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	165-169
19808956-7	2009	We also found that arsenite-induced phosphorylation of extracellular signal-regulated kinases (ERK) or c-Jun NH(2)-terminal kinases (JNK) was markedly suppressed by Tpl2 kinase inhibitor or Tpl2 short hairpin RNA.	arsenite	19-27	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	190-194
19808956-8	2009	Inhibition of arsenite-induced ERK or JNK signaling using a pharmacologic inhibitor of ERK or JNK substantially blocked COX-2 expression.	arsenite	14-22	mitogen-activated protein kinase 8	Homo sapiens	38-41
19808956-8	2009	Inhibition of arsenite-induced ERK or JNK signaling using a pharmacologic inhibitor of ERK or JNK substantially blocked COX-2 expression.	arsenite	14-22	mitogen-activated protein kinase 8	Homo sapiens	94-97
19808956-8	2009	Inhibition of arsenite-induced ERK or JNK signaling using a pharmacologic inhibitor of ERK or JNK substantially blocked COX-2 expression.	arsenite	14-22	prostaglandin-endoperoxide synthase 2	Homo sapiens	120-125
19808956-9	2009	Furthermore, inhibition of Tpl2 reduced the arsenite-induced promoter activity of NF-kappaB and activator protein-1 (AP-1), indicating that NF-kappaB and AP-1 are downstream transducers of arsenite-triggered Tpl2.	arsenite	44-52	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	27-31
19808956-9	2009	Furthermore, inhibition of Tpl2 reduced the arsenite-induced promoter activity of NF-kappaB and activator protein-1 (AP-1), indicating that NF-kappaB and AP-1 are downstream transducers of arsenite-triggered Tpl2.	arsenite	44-52	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	96-115
19808956-9	2009	Furthermore, inhibition of Tpl2 reduced the arsenite-induced promoter activity of NF-kappaB and activator protein-1 (AP-1), indicating that NF-kappaB and AP-1 are downstream transducers of arsenite-triggered Tpl2.	arsenite	44-52	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	117-121
19808956-9	2009	Furthermore, inhibition of Tpl2 reduced the arsenite-induced promoter activity of NF-kappaB and activator protein-1 (AP-1), indicating that NF-kappaB and AP-1 are downstream transducers of arsenite-triggered Tpl2.	arsenite	44-52	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	154-158
19808956-9	2009	Furthermore, inhibition of Tpl2 reduced the arsenite-induced promoter activity of NF-kappaB and activator protein-1 (AP-1), indicating that NF-kappaB and AP-1 are downstream transducers of arsenite-triggered Tpl2.	arsenite	44-52	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	208-212
19808956-9	2009	Furthermore, inhibition of Tpl2 reduced the arsenite-induced promoter activity of NF-kappaB and activator protein-1 (AP-1), indicating that NF-kappaB and AP-1 are downstream transducers of arsenite-triggered Tpl2.	arsenite	189-197	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	27-31
19808956-9	2009	Furthermore, inhibition of Tpl2 reduced the arsenite-induced promoter activity of NF-kappaB and activator protein-1 (AP-1), indicating that NF-kappaB and AP-1 are downstream transducers of arsenite-triggered Tpl2.	arsenite	189-197	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	96-115
19808956-9	2009	Furthermore, inhibition of Tpl2 reduced the arsenite-induced promoter activity of NF-kappaB and activator protein-1 (AP-1), indicating that NF-kappaB and AP-1 are downstream transducers of arsenite-triggered Tpl2.	arsenite	189-197	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	117-121
19808956-9	2009	Furthermore, inhibition of Tpl2 reduced the arsenite-induced promoter activity of NF-kappaB and activator protein-1 (AP-1), indicating that NF-kappaB and AP-1 are downstream transducers of arsenite-triggered Tpl2.	arsenite	189-197	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	154-158
19808956-9	2009	Furthermore, inhibition of Tpl2 reduced the arsenite-induced promoter activity of NF-kappaB and activator protein-1 (AP-1), indicating that NF-kappaB and AP-1 are downstream transducers of arsenite-triggered Tpl2.	arsenite	189-197	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	208-212
19808956-10	2009	Our results show that Tpl2 plays a key role in arsenite-induced COX-2 expression and PGE(2) production and further elucidate the role of Tpl2 in arsenite signals that activate ERK/JNK and NF-kappaB/AP-1 in JB6 P+ cells.	arsenite	47-55	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	22-26
19808956-10	2009	Our results show that Tpl2 plays a key role in arsenite-induced COX-2 expression and PGE(2) production and further elucidate the role of Tpl2 in arsenite signals that activate ERK/JNK and NF-kappaB/AP-1 in JB6 P+ cells.	arsenite	47-55	prostaglandin-endoperoxide synthase 2	Homo sapiens	64-69
19808956-10	2009	Our results show that Tpl2 plays a key role in arsenite-induced COX-2 expression and PGE(2) production and further elucidate the role of Tpl2 in arsenite signals that activate ERK/JNK and NF-kappaB/AP-1 in JB6 P+ cells.	arsenite	47-55	mitogen-activated protein kinase 8	Homo sapiens	180-183
19808956-10	2009	Our results show that Tpl2 plays a key role in arsenite-induced COX-2 expression and PGE(2) production and further elucidate the role of Tpl2 in arsenite signals that activate ERK/JNK and NF-kappaB/AP-1 in JB6 P+ cells.	arsenite	47-55	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	198-202
19808956-10	2009	Our results show that Tpl2 plays a key role in arsenite-induced COX-2 expression and PGE(2) production and further elucidate the role of Tpl2 in arsenite signals that activate ERK/JNK and NF-kappaB/AP-1 in JB6 P+ cells.	arsenite	145-153	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	137-141
19808956-10	2009	Our results show that Tpl2 plays a key role in arsenite-induced COX-2 expression and PGE(2) production and further elucidate the role of Tpl2 in arsenite signals that activate ERK/JNK and NF-kappaB/AP-1 in JB6 P+ cells.	arsenite	145-153	mitogen-activated protein kinase 8	Homo sapiens	180-183
19808956-10	2009	Our results show that Tpl2 plays a key role in arsenite-induced COX-2 expression and PGE(2) production and further elucidate the role of Tpl2 in arsenite signals that activate ERK/JNK and NF-kappaB/AP-1 in JB6 P+ cells.	arsenite	145-153	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	198-202
19577553-4	2009	Previously, we have demonstrated that arsenite can induce autophagy and death-associated protein kinase (DAPK) promoter hypermethylation in the SV-40 immortalized human uroepithelial cell line (SV-HUC-1).	arsenite	38-46	death associated protein kinase 1	Homo sapiens	105-109
19577553-6	2009	In the present study, we demonstrate that arsenite can activate the extracellular signaling-regulated protein kinase 1/2 (ERK1/2) signaling pathway after treatment in SV-HUC-1 cells by using immunocytochemistry and Western blotting.	arsenite	42-50	mitogen-activated protein kinase 3	Homo sapiens	122-128
19577553-9	2009	When the cells were pretreated with inhibitors 5-aza-CdR or U0126 for 24h, the effect of arsenite on ERK1/2, LC3B, Beclin-1 and DAPK proteins expression is suppressed.	arsenite	89-97	mitogen-activated protein kinase 3	Homo sapiens	101-107
19577553-9	2009	When the cells were pretreated with inhibitors 5-aza-CdR or U0126 for 24h, the effect of arsenite on ERK1/2, LC3B, Beclin-1 and DAPK proteins expression is suppressed.	arsenite	89-97	microtubule associated protein 1 light chain 3 beta	Homo sapiens	109-113
19577553-9	2009	When the cells were pretreated with inhibitors 5-aza-CdR or U0126 for 24h, the effect of arsenite on ERK1/2, LC3B, Beclin-1 and DAPK proteins expression is suppressed.	arsenite	89-97	beclin 1	Homo sapiens	115-123
19577553-9	2009	When the cells were pretreated with inhibitors 5-aza-CdR or U0126 for 24h, the effect of arsenite on ERK1/2, LC3B, Beclin-1 and DAPK proteins expression is suppressed.	arsenite	89-97	death associated protein kinase 1	Homo sapiens	128-132
19577553-10	2009	Furthermore, our results support the notion that arsenite can induce the ERK1/2 signaling pathway to stimulate autophagy and DAPK promoter hypermethylation in human uroepithelial SV-HUC-1 cells.	arsenite	49-57	mitogen-activated protein kinase 3	Homo sapiens	73-79
19577553-10	2009	Furthermore, our results support the notion that arsenite can induce the ERK1/2 signaling pathway to stimulate autophagy and DAPK promoter hypermethylation in human uroepithelial SV-HUC-1 cells.	arsenite	49-57	death associated protein kinase 1	Homo sapiens	125-129
19661161-4	2009	We further examine the role of the two Drosophila eIF2alpha kinases, PEK and GCN2, in regulating SG formation in response to heat and arsenite stress.	arsenite	134-142	eukaryotic translation initiation factor 2 subunit alpha	Drosophila melanogaster	50-59
19724867-0	2009	Increased sensitivity to platinating agents and arsenite in human ovarian cancer by downregulation of ASNA1.	arsenite	48-56	guided entry of tail-anchored proteins factor 3, ATPase	Homo sapiens	102-107
19724867-3	2009	ASNA1 is a possible subunit of a transport system for cisplatin and arsenite due to homology to arsA, an ATPase in the E. coli ars-complex responsible for efflux of arsenite and antimonite.	arsenite	68-76	guided entry of tail-anchored proteins factor 3, ATPase	Homo sapiens	0-5
19724867-3	2009	ASNA1 is a possible subunit of a transport system for cisplatin and arsenite due to homology to arsA, an ATPase in the E. coli ars-complex responsible for efflux of arsenite and antimonite.	arsenite	68-76	ATPase	Escherichia coli	105-111
19724867-3	2009	ASNA1 is a possible subunit of a transport system for cisplatin and arsenite due to homology to arsA, an ATPase in the E. coli ars-complex responsible for efflux of arsenite and antimonite.	arsenite	165-173	guided entry of tail-anchored proteins factor 3, ATPase	Homo sapiens	0-5
19724867-3	2009	ASNA1 is a possible subunit of a transport system for cisplatin and arsenite due to homology to arsA, an ATPase in the E. coli ars-complex responsible for efflux of arsenite and antimonite.	arsenite	165-173	ATPase	Escherichia coli	105-111
19724867-5	2009	The purpose with this study was to evaluate if ASNA1 expression influenced cisplatin, carboplatin, oxaliplatin or arsenite sensitivity in ovarian cancer.	arsenite	114-122	guided entry of tail-anchored proteins factor 3, ATPase	Homo sapiens	47-52
19724867-9	2009	Down-regulated ASNA1 expression was associated with retarded growth and increased sensitivity to cisplatin, carboplatin, oxaliplatin and arsenite whereas the cisplatin resistant 2008/A overexpresses ASNA1.	arsenite	137-145	guided entry of tail-anchored proteins factor 3, ATPase	Homo sapiens	15-20
19661161-4	2009	We further examine the role of the two Drosophila eIF2alpha kinases, PEK and GCN2, in regulating SG formation in response to heat and arsenite stress.	arsenite	134-142	pancreatic eIF-2alpha kinase	Drosophila melanogaster	69-72
19661161-4	2009	We further examine the role of the two Drosophila eIF2alpha kinases, PEK and GCN2, in regulating SG formation in response to heat and arsenite stress.	arsenite	134-142	Gcn2	Drosophila melanogaster	77-81
19661161-5	2009	While arsenite-induced SGs are dependent upon eIF2alpha phosphorylation, primarily via PEK, heat-induced SGs are phospho-eIF2alpha-independent.	arsenite	6-14	eukaryotic translation initiation factor 2 subunit alpha	Drosophila melanogaster	46-55
19661161-5	2009	While arsenite-induced SGs are dependent upon eIF2alpha phosphorylation, primarily via PEK, heat-induced SGs are phospho-eIF2alpha-independent.	arsenite	6-14	pancreatic eIF-2alpha kinase	Drosophila melanogaster	87-90
19764221-1	2009	The objective of this study was to explore a bioremediation strategy based on injecting NO3- to support the anoxic oxidation of ferrous iron (Fe(II)) and arsenite (As(II)) in the subsurface as a means to immobilize As in the form of arsenate (As(V)) adsorbed onto biogenic ferric (Fe(III)) (hydr)oxides.	arsenite	154-162	NBL1, DAN family BMP antagonist	Homo sapiens	88-91
19622383-8	2009	Although arsenite did not alter Ang-1 mRNA expression, it increased intracellular Ang-1 protein levels in a dose-dependent manner, suggesting a role for arsenite in the intracellular trapping of Ang-1.	arsenite	9-17	angiopoietin 1	Homo sapiens	82-87
19622383-9	2009	Contrary to Ang-1, the expression of VEGF mRNA was dose-dependently up-regulated by arsenite.	arsenite	84-92	vascular endothelial growth factor A	Homo sapiens	37-41
19622383-10	2009	Treatment with N-actyl-l:-cysteine (NAC) alone decreased the release of Ang-1, but failed to attenuate the arsenite-induced decrease in Ang-1 secretion, while NAC completely blocked the arsenite-stimulated VEGF secretion.	arsenite	186-194	X-linked Kx blood group	Homo sapiens	159-162
19622383-10	2009	Treatment with N-actyl-l:-cysteine (NAC) alone decreased the release of Ang-1, but failed to attenuate the arsenite-induced decrease in Ang-1 secretion, while NAC completely blocked the arsenite-stimulated VEGF secretion.	arsenite	186-194	vascular endothelial growth factor A	Homo sapiens	206-210
19622383-11	2009	These results indicate that reactive oxygen species are involved in the regulation of VEGF, but not of Ang-1, secretion in response to arsenite treatment in pericytes.	arsenite	135-143	vascular endothelial growth factor A	Homo sapiens	86-90
19622383-13	2009	In conclusion, arsenite decreases Ang-1 secretion and increases VEGF secretion, which may offer new insight into understanding the arsenite toxicity associated with vascular instability and subsequent development of vascular disease.	arsenite	15-23	angiopoietin 1	Homo sapiens	34-39
19622383-13	2009	In conclusion, arsenite decreases Ang-1 secretion and increases VEGF secretion, which may offer new insight into understanding the arsenite toxicity associated with vascular instability and subsequent development of vascular disease.	arsenite	15-23	vascular endothelial growth factor A	Homo sapiens	64-68
23100771-3	2009	The gene product of arsB is an integral membrane protein and it is sufficient to provide resistance to arsenite and antimonite.	arsenite	103-111	arsenic efflux pump protein	Staphylococcus aureus	20-24
23100771-5	2009	Cells containing the His-tagged arsB gene were resistant to arsenite and antimonite.	arsenite	60-68	arsenic efflux pump protein	Staphylococcus aureus	32-36
19622383-0	2009	Coordinated regulation of angiopoietin-1 and vascular endothelial growth factor by arsenite in human brain microvascular pericytes: implications of arsenite-induced vascular dysfunction.	arsenite	83-91	angiopoietin 1	Homo sapiens	26-40
19622383-0	2009	Coordinated regulation of angiopoietin-1 and vascular endothelial growth factor by arsenite in human brain microvascular pericytes: implications of arsenite-induced vascular dysfunction.	arsenite	83-91	vascular endothelial growth factor A	Homo sapiens	45-79
19622383-5	2009	In this study, we used human brain microvascular pericytes (HBMP) to evaluate the effects of arsenite on Ang-1 and VEGF regulation.	arsenite	93-101	angiopoietin 1	Homo sapiens	105-110
19622383-5	2009	In this study, we used human brain microvascular pericytes (HBMP) to evaluate the effects of arsenite on Ang-1 and VEGF regulation.	arsenite	93-101	vascular endothelial growth factor A	Homo sapiens	115-119
19622383-7	2009	Arsenite decreased Ang-1 secretion in a time and dose-dependent manner, while it increased VEGF secretion.	arsenite	0-8	angiopoietin 1	Homo sapiens	19-24
19622383-7	2009	Arsenite decreased Ang-1 secretion in a time and dose-dependent manner, while it increased VEGF secretion.	arsenite	0-8	vascular endothelial growth factor A	Homo sapiens	91-95
19622383-8	2009	Although arsenite did not alter Ang-1 mRNA expression, it increased intracellular Ang-1 protein levels in a dose-dependent manner, suggesting a role for arsenite in the intracellular trapping of Ang-1.	arsenite	9-17	angiopoietin 1	Homo sapiens	82-87
19805235-1	2009	Expressed in liver, aquaglyceroporin-9 (AQP9) is permeated by glycerol, arsenite, and other small, neutral solutes.	arsenite	72-80	aquaporin 9	Mus musculus	20-38
19805235-1	2009	Expressed in liver, aquaglyceroporin-9 (AQP9) is permeated by glycerol, arsenite, and other small, neutral solutes.	arsenite	72-80	aquaporin 9	Mus musculus	40-44
19453443-2	2009	ars5 was the strongest arsenate- and arsenite-resistant mutant identified in this genetic screen.	arsenite	37-45	proteasome alpha subunit F1	Arabidopsis thaliana	0-4
19084030-8	2009	Arsenite treatment induces the accumulation of Ub-protein conjugates, indicating that the activation of this mechanism may explain the differences observed between the mRNA and protein expression of CYP3A4 induction.	arsenite	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	199-205
19248796-1	2009	Three cytosolic phosphorolytic/arsenolytic enzymes, (purine nucleoside phosphorylase [PNP], glycogen phosphorylase, glyceraldehyde-3-phosphate dehydrogenase) have been shown to mediate reduction of arsenate (AsV) to the more toxic arsenite (AsIII) in a thiol-dependent manner.	arsenite	231-239	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	116-156
19084030-0	2009	Arsenite and its metabolites, MMA(III) and DMA(III), modify CYP3A4, PXR and RXR alpha expression in the small intestine of CYP3A4 transgenic mice.	arsenite	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	60-66
19084030-0	2009	Arsenite and its metabolites, MMA(III) and DMA(III), modify CYP3A4, PXR and RXR alpha expression in the small intestine of CYP3A4 transgenic mice.	arsenite	0-8	nuclear receptor subfamily 1, group I, member 2	Mus musculus	68-71
19084030-0	2009	Arsenite and its metabolites, MMA(III) and DMA(III), modify CYP3A4, PXR and RXR alpha expression in the small intestine of CYP3A4 transgenic mice.	arsenite	0-8	retinoid X receptor alpha	Mus musculus	76-85
19084030-0	2009	Arsenite and its metabolites, MMA(III) and DMA(III), modify CYP3A4, PXR and RXR alpha expression in the small intestine of CYP3A4 transgenic mice.	arsenite	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	123-129
19084030-3	2009	Several reports have established that exposure to arsenite modifies P450 expression by decreasing or increasing mRNA and protein levels.	arsenite	50-58	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	68-72
19526463-7	2009	Together these findings demonstrate that a posttranslational mechanism involving decreases in the cellular heme pool by arsenite-induced HO-1 may contribute to arsenite-mediated downregulation of CYP1A1.	arsenite	120-128	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	196-202
19414066-5	2009	We report that exposure to UVA after arsenite pretreatment enhanced ROS production, p38 MAP kinase activation, and induction of a redox-sensitive gene product, heme oxygenase-1, compared to either stimulus alone.	arsenite	37-45	mitogen-activated protein kinase 14	Mus musculus	84-87
19414066-8	2009	Furthermore, arsenite-induced, but not UVA-induced, p38 activation and HO-1 expression were dependent upon NADPH oxidase activity.	arsenite	13-21	mitogen-activated protein kinase 14	Mus musculus	52-55
19519318-0	2009	PI3K/Akt/JNK/c-Jun signaling pathway is a mediator for arsenite-induced cyclin D1 expression and cell growth in human bronchial epithelial cells.	arsenite	55-63	AKT serine/threonine kinase 1	Homo sapiens	5-8
19519318-0	2009	PI3K/Akt/JNK/c-Jun signaling pathway is a mediator for arsenite-induced cyclin D1 expression and cell growth in human bronchial epithelial cells.	arsenite	55-63	mitogen-activated protein kinase 8	Homo sapiens	9-12
19519318-0	2009	PI3K/Akt/JNK/c-Jun signaling pathway is a mediator for arsenite-induced cyclin D1 expression and cell growth in human bronchial epithelial cells.	arsenite	55-63	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	13-18
19519318-0	2009	PI3K/Akt/JNK/c-Jun signaling pathway is a mediator for arsenite-induced cyclin D1 expression and cell growth in human bronchial epithelial cells.	arsenite	55-63	cyclin D1	Homo sapiens	72-81
19519318-3	2009	In this study, we demonstrated that arsenite upregulates cyclin D1 expression/activity to promote the growth of human bronchial epithelial Beas-2B cells.	arsenite	36-44	cyclin D1	Homo sapiens	57-66
19519318-5	2009	The inhibition of JNKs or c-Jun by chemical or genetic inhibitors blocks the cyclin D1 induction mediated by arsenite.	arsenite	109-117	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	26-31
19519318-5	2009	The inhibition of JNKs or c-Jun by chemical or genetic inhibitors blocks the cyclin D1 induction mediated by arsenite.	arsenite	109-117	cyclin D1	Homo sapiens	77-86
19519318-6	2009	Furthermore, using a loss of function mutant of p85 (Deltap85, a subunit of PI3K) or dominant-negative Akt (DN-Akt), we showed that PI3K and Akt act as the upstream regulators of JNKs and c-Jun in arsenite-mediated growth promotion.	arsenite	197-205	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	48-51
19519318-7	2009	Overall, our data suggest a pathway of PI-3K/Akt/JNK/c-Jun/cylin D1 signaling in response to arsenite in human bronchial epithelial cells.	arsenite	93-101	AKT serine/threonine kinase 1	Homo sapiens	45-48
19519318-7	2009	Overall, our data suggest a pathway of PI-3K/Akt/JNK/c-Jun/cylin D1 signaling in response to arsenite in human bronchial epithelial cells.	arsenite	93-101	mitogen-activated protein kinase 8	Homo sapiens	49-52
19519318-7	2009	Overall, our data suggest a pathway of PI-3K/Akt/JNK/c-Jun/cylin D1 signaling in response to arsenite in human bronchial epithelial cells.	arsenite	93-101	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	53-58
19524636-5	2009	Indeed, we observed clear evidence of acquired cancer phenotype by 20 weeks of arsenite exposure including the formation of giant cells, a >4-fold increase in colony formation in soft agar and a approximately 2.5-fold increase in matrix metalloproteinase-9 secretion, an enzyme often secreted by cancer cells to help invade through the local extra-cellular matrix.	arsenite	79-87	matrix metallopeptidase 9	Homo sapiens	233-259
19439532-5	2009	Treatment of a gastric cancer cell line (AGS) with arsenite (100 microM) preferentially generated tra2beta4 isoform and caused translocation of Tra2beta from the nucleus to the cytoplasm in association with enhanced phosphorylation during the initial 4-6 h (acute phase).	arsenite	51-59	transformer 2 beta	Rattus norvegicus	144-152
19553191-0	2009	BRCA2-dependent homologous recombination is required for repair of Arsenite-induced replication lesions in mammalian cells.	arsenite	67-75	BRCA2 DNA repair associated	Homo sapiens	0-5
19470404-1	2009	Arsenite effects on the benzo[a]pyrene diol epoxide (BPDE)-DNA adduct-induced mutation were evaluated in three human lung cell-lines--A549 (wild-type p53), WI38-VA13 (p53 inhibited by SV40 large-T antigen), and H1299 (p53-null)--by using the pSP189 shuttle vector, which carries a mutation target supF gene.	arsenite	0-8	tumor protein p53	Homo sapiens	167-170
19470404-1	2009	Arsenite effects on the benzo[a]pyrene diol epoxide (BPDE)-DNA adduct-induced mutation were evaluated in three human lung cell-lines--A549 (wild-type p53), WI38-VA13 (p53 inhibited by SV40 large-T antigen), and H1299 (p53-null)--by using the pSP189 shuttle vector, which carries a mutation target supF gene.	arsenite	0-8	tumor protein p53	Homo sapiens	167-170
19470404-5	2009	These results suggest that arsenite potentiates the BPDE-induced supF mutation via a p53-independent mechanism.	arsenite	27-35	tumor protein p53	Homo sapiens	85-88
19442679-10	2009	Because the cellular uptake of iAs(III) is mediated by aquaporin proteins, and because the resistance of cells to arsenite can be influenced by lower arsenic uptake due to lower expression of aquaporin proteins (AQP 3, 7 and 9), the expression of several members of the aquaporin family was also examined.	arsenite	114-122	aquaporin 3 (Gill blood group)	Homo sapiens	212-226
19350206-6	2009	Aquaporins of the NIP (nodulin26-like intrinsic protein) subfamily were shown to transport arsenite in planta and in heterologous systems.	arsenite	91-99	CDP-L-ribitol pyrophosphorylase A	Homo sapiens	18-21
19350206-6	2009	Aquaporins of the NIP (nodulin26-like intrinsic protein) subfamily were shown to transport arsenite in planta and in heterologous systems.	arsenite	91-99	CDP-L-ribitol pyrophosphorylase A	Homo sapiens	23-55
19429265-6	2009	Besides, arsenite exposure increased the levels of reactive oxygen species (ROS), serum TNF-alpha, As accumulation and lipid peroxidation and decreased the activities of the antioxidant enzymes and glutathione in the testicular tissue.	arsenite	9-17	tumor necrosis factor	Rattus norvegicus	88-97
19341753-1	2009	Aquaporin (AQP) 9 is a member of the aquaglyceroporin subfamily of AQPs in the transfer of water and small solutes such as glycerol and arsenite.	arsenite	136-144	aquaporin 9	Mus musculus	0-17
19341753-3	2009	In the present study, we examined the contribution of AQP9 to the uptake of inorganic arsenite, thereby increasing arsenic-induced cytotoxicity in primary mouse hepatocytes.	arsenite	86-94	aquaporin 9	Mus musculus	54-58
19341753-4	2009	Pretreatment with sorbitol as a competitive inhibitor of AQP9 and siRNA-mediated knockdown of AQP9 resulted in a significant decrease of arsenite uptake in the cell and its cytotoxicity.	arsenite	137-145	aquaporin 9	Mus musculus	57-61
19341753-4	2009	Pretreatment with sorbitol as a competitive inhibitor of AQP9 and siRNA-mediated knockdown of AQP9 resulted in a significant decrease of arsenite uptake in the cell and its cytotoxicity.	arsenite	137-145	aquaporin 9	Mus musculus	94-98
19341753-5	2009	Furthermore, overexpression of AQP9 in HEK293 cells led to the enhancement of intracellular arsenic concentration, resulting in enhanced cytotoxicity after arsenite exposure.	arsenite	156-164	aquaporin 9	Homo sapiens	31-35
19341753-6	2009	These results suggest that AQP9 is a channel to define arsenite sensitivity in primary mouse hepatocytes.	arsenite	55-63	aquaporin 9	Mus musculus	27-31
19526463-0	2009	Investigations of the posttranslational mechanism of arsenite-mediated downregulation of human cytochrome P4501A1 levels: the role of heme oxygenase-1.	arsenite	53-61	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	95-113
19526463-0	2009	Investigations of the posttranslational mechanism of arsenite-mediated downregulation of human cytochrome P4501A1 levels: the role of heme oxygenase-1.	arsenite	53-61	heme oxygenase 1	Homo sapiens	134-150
19526463-1	2009	Arsenite, an environmental cocontaminant of polycyclic aromatic hydrocarbons (PAHs), diminishes the PAH-mediated upregulation of human CYP1A1, the enzyme that bioactivates PAHs to carcinogenic metabolites.	arsenite	0-8	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	135-141
19526463-3	2009	We hypothesize that arsenite induces heme oxygenase-1 (HO-1), which catabolizes CYP1A1 heme or cellular heme pools, thereby downregulating CYP1A1.	arsenite	20-28	heme oxygenase 1	Homo sapiens	37-53
19526463-3	2009	We hypothesize that arsenite induces heme oxygenase-1 (HO-1), which catabolizes CYP1A1 heme or cellular heme pools, thereby downregulating CYP1A1.	arsenite	20-28	heme oxygenase 1	Homo sapiens	55-59
19526463-3	2009	We hypothesize that arsenite induces heme oxygenase-1 (HO-1), which catabolizes CYP1A1 heme or cellular heme pools, thereby downregulating CYP1A1.	arsenite	20-28	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	80-86
19526463-3	2009	We hypothesize that arsenite induces heme oxygenase-1 (HO-1), which catabolizes CYP1A1 heme or cellular heme pools, thereby downregulating CYP1A1.	arsenite	20-28	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	139-145
19526463-4	2009	Arsenite (5 microM), in HepG2 cells, induced HO-1 mRNA 7.4-fold over the 48 h observation period, and it upregulated HO-1 protein expression.	arsenite	0-8	heme oxygenase 1	Homo sapiens	45-49
19526463-4	2009	Arsenite (5 microM), in HepG2 cells, induced HO-1 mRNA 7.4-fold over the 48 h observation period, and it upregulated HO-1 protein expression.	arsenite	0-8	heme oxygenase 1	Homo sapiens	117-121
19526463-5	2009	Arsenite decreased the induction of CYP1A1 by a PAH, benzo[k]fluoranthene (BKF), by 50%; and transfection of HepG2 cells with siRNA targeting the human HO-1 gene, reduced the arsenite downregulation of BKF-induced CYP1A1 from 54% to 27%, relative to untransfected cells.	arsenite	0-8	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	36-42
19526463-5	2009	Arsenite decreased the induction of CYP1A1 by a PAH, benzo[k]fluoranthene (BKF), by 50%; and transfection of HepG2 cells with siRNA targeting the human HO-1 gene, reduced the arsenite downregulation of BKF-induced CYP1A1 from 54% to 27%, relative to untransfected cells.	arsenite	0-8	heme oxygenase 1	Homo sapiens	152-156
19526463-5	2009	Arsenite decreased the induction of CYP1A1 by a PAH, benzo[k]fluoranthene (BKF), by 50%; and transfection of HepG2 cells with siRNA targeting the human HO-1 gene, reduced the arsenite downregulation of BKF-induced CYP1A1 from 54% to 27%, relative to untransfected cells.	arsenite	0-8	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	214-220
19526463-5	2009	Arsenite decreased the induction of CYP1A1 by a PAH, benzo[k]fluoranthene (BKF), by 50%; and transfection of HepG2 cells with siRNA targeting the human HO-1 gene, reduced the arsenite downregulation of BKF-induced CYP1A1 from 54% to 27%, relative to untransfected cells.	arsenite	175-183	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	36-42
19526463-5	2009	Arsenite decreased the induction of CYP1A1 by a PAH, benzo[k]fluoranthene (BKF), by 50%; and transfection of HepG2 cells with siRNA targeting the human HO-1 gene, reduced the arsenite downregulation of BKF-induced CYP1A1 from 54% to 27%, relative to untransfected cells.	arsenite	175-183	heme oxygenase 1	Homo sapiens	152-156
19526463-7	2009	Together these findings demonstrate that a posttranslational mechanism involving decreases in the cellular heme pool by arsenite-induced HO-1 may contribute to arsenite-mediated downregulation of CYP1A1.	arsenite	120-128	heme oxygenase 1	Homo sapiens	137-141
19526463-7	2009	Together these findings demonstrate that a posttranslational mechanism involving decreases in the cellular heme pool by arsenite-induced HO-1 may contribute to arsenite-mediated downregulation of CYP1A1.	arsenite	160-168	heme oxygenase 1	Homo sapiens	137-141
19526463-7	2009	Together these findings demonstrate that a posttranslational mechanism involving decreases in the cellular heme pool by arsenite-induced HO-1 may contribute to arsenite-mediated downregulation of CYP1A1.	arsenite	160-168	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	196-202
19382146-5	2009	Here, we report that arsenite and its metabolite monomethylarsonous acid (MMA(III)) strongly decreased expression and protein level of Xeroderma pigmentosum complementation group C (XPC), which is believed to be the principle initiator of global genome NER.	arsenite	21-29	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	135-180
19273602-4	2009	Here, we report that p300/CBP directly acetylates Nrf2 in response to arsenite-induced stress.	arsenite	70-78	E1A binding protein p300	Homo sapiens	21-25
19273602-4	2009	Here, we report that p300/CBP directly acetylates Nrf2 in response to arsenite-induced stress.	arsenite	70-78	CREB binding protein	Homo sapiens	26-29
19273602-4	2009	Here, we report that p300/CBP directly acetylates Nrf2 in response to arsenite-induced stress.	arsenite	70-78	NFE2 like bZIP transcription factor 2	Homo sapiens	50-54
19382146-5	2009	Here, we report that arsenite and its metabolite monomethylarsonous acid (MMA(III)) strongly decreased expression and protein level of Xeroderma pigmentosum complementation group C (XPC), which is believed to be the principle initiator of global genome NER.	arsenite	21-29	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	182-185
19371606-0	2009	Induction of heme oxygenase 1 by arsenite inhibits cytokine-induced monocyte adhesion to human endothelial cells.	arsenite	33-41	heme oxygenase 1	Homo sapiens	13-29
19371606-2	2009	Arsenite, as an oxidative stressor, is a potent inducer of HO-1 in human and rodent cells.	arsenite	0-8	heme oxygenase 1	Homo sapiens	59-63
19371606-3	2009	In this study, we investigated the mechanistic role of arsenite-induced HO-1 in modulating tumor necrosis factor alpha (TNF-alpha) induced monocyte adhesion to human umbilical vein endothelial cells (HUVEC).	arsenite	55-63	heme oxygenase 1	Homo sapiens	72-76
19371606-3	2009	In this study, we investigated the mechanistic role of arsenite-induced HO-1 in modulating tumor necrosis factor alpha (TNF-alpha) induced monocyte adhesion to human umbilical vein endothelial cells (HUVEC).	arsenite	55-63	tumor necrosis factor	Homo sapiens	91-118
19371606-3	2009	In this study, we investigated the mechanistic role of arsenite-induced HO-1 in modulating tumor necrosis factor alpha (TNF-alpha) induced monocyte adhesion to human umbilical vein endothelial cells (HUVEC).	arsenite	55-63	tumor necrosis factor	Homo sapiens	120-129
19371606-4	2009	Arsenite pretreatment, which upregulated HO-1 in a time- and concentration-dependent manner, inhibited TNF-alpha-induced monocyte adhesion to HUVEC and intercellular adhesion molecule 1 protein expression by 50% and 40%, respectively.	arsenite	0-8	heme oxygenase 1	Homo sapiens	41-45
19371606-4	2009	Arsenite pretreatment, which upregulated HO-1 in a time- and concentration-dependent manner, inhibited TNF-alpha-induced monocyte adhesion to HUVEC and intercellular adhesion molecule 1 protein expression by 50% and 40%, respectively.	arsenite	0-8	tumor necrosis factor	Homo sapiens	103-112
19371606-4	2009	Arsenite pretreatment, which upregulated HO-1 in a time- and concentration-dependent manner, inhibited TNF-alpha-induced monocyte adhesion to HUVEC and intercellular adhesion molecule 1 protein expression by 50% and 40%, respectively.	arsenite	0-8	intercellular adhesion molecule 1	Homo sapiens	152-185
19371606-5	2009	Importantly, knockdown of HO-1 by small interfering RNA abolished the arsenite-induced inhibitory effects.	arsenite	70-78	heme oxygenase 1	Homo sapiens	26-30
19371606-6	2009	These results indicate that induction of HO-1 by arsenite inhibits the cytokine-induced monocyte adhesion to HUVEC by suppressing adhesion molecule expression.	arsenite	49-57	heme oxygenase 1	Homo sapiens	41-45
19371606-7	2009	These findings established an important mechanistic link between the functional monocyte adhesion properties of HUVEC and the induction of HO-1 by arsenite.	arsenite	147-155	heme oxygenase 1	Homo sapiens	139-143
19331829-0	2009	Human hnRNP Q re-localizes to cytoplasmic granules upon PMA, thapsigargin, arsenite and heat-shock treatments.	arsenite	75-83	synaptotagmin binding cytoplasmic RNA interacting protein	Homo sapiens	6-13
19332886-5	2009	Knockdown of angiogenin, but not related ribonucleases, inhibits arsenite-induced tiRNA production and translational arrest.	arsenite	65-73	angiogenin	Homo sapiens	13-23
19332886-6	2009	In contrast, knockdown of the angiogenin inhibitor RNH1 enhances tiRNA production and promotes arsenite-induced translational arrest.	arsenite	95-103	angiogenin	Homo sapiens	30-40
19332886-6	2009	In contrast, knockdown of the angiogenin inhibitor RNH1 enhances tiRNA production and promotes arsenite-induced translational arrest.	arsenite	95-103	ribonuclease/angiogenin inhibitor 1	Homo sapiens	51-55
19331829-9	2009	Our data suggest that the nuclear localization of hnRNP Q might be modified after different treatments, such as: PMA, thapsigargin, arsenite and heat shock.	arsenite	132-140	synaptotagmin binding cytoplasmic RNA interacting protein	Homo sapiens	50-57
19432328-0	2009	[Arsenite removal performance by modified GAC].	arsenite	1-9	glutaminase	Homo sapiens	42-45
19432328-1	2009	Two kinds of Fe-Mn oxide impregnated GAC (FM-GAC-1, FM-GAC-2) were prepared and their arsenite removal performance were studied.	arsenite	86-94	glutaminase	Homo sapiens	37-40
19432328-2	2009	The adsorption isotherm and reaction kinetic models of arsenite on the two kinds of modified GAC and influence of solution pH, temperature and co-exist anions were investigated in the study.	arsenite	55-63	glutaminase	Homo sapiens	93-96
19432328-3	2009	The results showed FM-GAC-1 and FM-GAC-2 can adsorb arsenite effectively, the adsorption capacities were 32.37 mg x g(-1) and 26.67 mg x g(-1) respectively.	arsenite	52-60	glutaminase	Homo sapiens	19-27
19432328-3	2009	The results showed FM-GAC-1 and FM-GAC-2 can adsorb arsenite effectively, the adsorption capacities were 32.37 mg x g(-1) and 26.67 mg x g(-1) respectively.	arsenite	52-60	glutaminase	Homo sapiens	22-25
19432328-8	2009	Some co-exist anions can influence arsenite adsorption on modified GAC when their concentration were 200 times of arsenite.	arsenite	35-43	glutaminase	Homo sapiens	67-70
19432328-8	2009	Some co-exist anions can influence arsenite adsorption on modified GAC when their concentration were 200 times of arsenite.	arsenite	114-122	glutaminase	Homo sapiens	67-70
19432328-9	2009	It was found that SiO3(2-), PO3(2-), NO3(-) had a significant negative influence on arsenite removal by FM-GAC-1 and SiO3(2-), CO3(2-) can markedly decrease arsenite adsorption on FM-GAC-2.	arsenite	84-92	glutaminase	Homo sapiens	104-112
19056730-5	2009	Inhibition of PARP-1 activity by 3-aminobenzamide or small interfering RNA silencing of PARP-1 expression significantly increases UVR-induced 8-OHdG formation, suggesting that inhibition of PARP-1 activity by arsenite contributes to oxidative DNA damage.	arsenite	209-217	poly(ADP-ribose) polymerase 1	Homo sapiens	14-20
19056730-5	2009	Inhibition of PARP-1 activity by 3-aminobenzamide or small interfering RNA silencing of PARP-1 expression significantly increases UVR-induced 8-OHdG formation, suggesting that inhibition of PARP-1 activity by arsenite contributes to oxidative DNA damage.	arsenite	209-217	poly(ADP-ribose) polymerase 1	Homo sapiens	88-94
19056730-0	2009	Inhibition of poly(ADP-ribose) polymerase-1 by arsenite interferes with repair of oxidative DNA damage.	arsenite	47-55	poly(ADP-ribose) polymerase 1	Homo sapiens	14-43
19056730-5	2009	Inhibition of PARP-1 activity by 3-aminobenzamide or small interfering RNA silencing of PARP-1 expression significantly increases UVR-induced 8-OHdG formation, suggesting that inhibition of PARP-1 activity by arsenite contributes to oxidative DNA damage.	arsenite	209-217	poly(ADP-ribose) polymerase 1	Homo sapiens	88-94
19432328-9	2009	It was found that SiO3(2-), PO3(2-), NO3(-) had a significant negative influence on arsenite removal by FM-GAC-1 and SiO3(2-), CO3(2-) can markedly decrease arsenite adsorption on FM-GAC-2.	arsenite	84-92	glutaminase	Homo sapiens	107-110
19056730-6	2009	PARP-1 is a zinc finger protein, and mass spectrometry analysis reveals that arsenite can occupy a synthetic apopeptide representing the first zinc finger of PARP-1 (PARPzf).	arsenite	77-85	poly(ADP-ribose) polymerase 1	Homo sapiens	0-6
19056730-4	2009	Arsenite suppresses UVR-induced PARP-1 activation in a concentration-dependent manner.	arsenite	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	32-38
19432328-9	2009	It was found that SiO3(2-), PO3(2-), NO3(-) had a significant negative influence on arsenite removal by FM-GAC-1 and SiO3(2-), CO3(2-) can markedly decrease arsenite adsorption on FM-GAC-2.	arsenite	157-165	glutaminase	Homo sapiens	104-112
19056730-6	2009	PARP-1 is a zinc finger protein, and mass spectrometry analysis reveals that arsenite can occupy a synthetic apopeptide representing the first zinc finger of PARP-1 (PARPzf).	arsenite	77-85	poly(ADP-ribose) polymerase 1	Homo sapiens	158-164
19056730-8	2009	Addition of Zn(II) abolished arsenite enhancement of UVR-stimulated 8-OHdG generation and restored PARP-1 activity.	arsenite	29-37	poly(ADP-ribose) polymerase 1	Homo sapiens	99-105
19432328-9	2009	It was found that SiO3(2-), PO3(2-), NO3(-) had a significant negative influence on arsenite removal by FM-GAC-1 and SiO3(2-), CO3(2-) can markedly decrease arsenite adsorption on FM-GAC-2.	arsenite	157-165	glutaminase	Homo sapiens	107-110
19056730-9	2009	Our findings demonstrate that arsenite inhibits oxidative DNA damage repair and suggest that interaction of arsenite with the PARP-1 zinc finger domain contributes to the inhibition of PARP-1 activity by arsenite.	arsenite	30-38	poly(ADP-ribose) polymerase 1	Homo sapiens	126-132
19056730-9	2009	Our findings demonstrate that arsenite inhibits oxidative DNA damage repair and suggest that interaction of arsenite with the PARP-1 zinc finger domain contributes to the inhibition of PARP-1 activity by arsenite.	arsenite	30-38	poly(ADP-ribose) polymerase 1	Homo sapiens	185-191
19056730-9	2009	Our findings demonstrate that arsenite inhibits oxidative DNA damage repair and suggest that interaction of arsenite with the PARP-1 zinc finger domain contributes to the inhibition of PARP-1 activity by arsenite.	arsenite	108-116	poly(ADP-ribose) polymerase 1	Homo sapiens	126-132
19056730-9	2009	Our findings demonstrate that arsenite inhibits oxidative DNA damage repair and suggest that interaction of arsenite with the PARP-1 zinc finger domain contributes to the inhibition of PARP-1 activity by arsenite.	arsenite	108-116	poly(ADP-ribose) polymerase 1	Homo sapiens	185-191
19056730-9	2009	Our findings demonstrate that arsenite inhibits oxidative DNA damage repair and suggest that interaction of arsenite with the PARP-1 zinc finger domain contributes to the inhibition of PARP-1 activity by arsenite.	arsenite	108-116	poly(ADP-ribose) polymerase 1	Homo sapiens	126-132
19056730-9	2009	Our findings demonstrate that arsenite inhibits oxidative DNA damage repair and suggest that interaction of arsenite with the PARP-1 zinc finger domain contributes to the inhibition of PARP-1 activity by arsenite.	arsenite	108-116	poly(ADP-ribose) polymerase 1	Homo sapiens	185-191
19432328-10	2009	As a whole, FM-GAC-1 had better arsenite removal performance than FM-GAC-2.	arsenite	32-40	glutaminase	Homo sapiens	12-20
19432328-10	2009	As a whole, FM-GAC-1 had better arsenite removal performance than FM-GAC-2.	arsenite	32-40	glutaminase	Homo sapiens	15-18
19337508-15	2009	The in vitro results also showed a dose-response relationship between arsenite concentrations and hTERT expression and reached the peak at 1 microM.	arsenite	70-78	telomerase reverse transcriptase	Homo sapiens	98-103
19059425-0	2009	c-Jun/AP-1 pathway-mediated cyclin D1 expression participates in low dose arsenite-induced transformation in mouse epidermal JB6 Cl41 cells.	arsenite	74-82	jun proto-oncogene	Mus musculus	0-5
19059425-0	2009	c-Jun/AP-1 pathway-mediated cyclin D1 expression participates in low dose arsenite-induced transformation in mouse epidermal JB6 Cl41 cells.	arsenite	74-82	cyclin D1	Mus musculus	28-37
19059425-2	2009	Our previous work reveals that arsenite exposure is able to induce cell transformation in mouse epidermal cell JB6 Cl41 through the activation of ERK, rather than JNK pathway.	arsenite	31-39	mitogen-activated protein kinase 8	Mus musculus	163-166
19059425-4	2009	Our results showed that treatment of cells with low dose arsenite induced activation of c-Jun/AP-1 pathway, and ectopic expression of dominant negative mutant of c-Jun (TAM67) blocked arsenite-induced transformation.	arsenite	57-65	jun proto-oncogene	Mus musculus	88-93
19059425-4	2009	Our results showed that treatment of cells with low dose arsenite induced activation of c-Jun/AP-1 pathway, and ectopic expression of dominant negative mutant of c-Jun (TAM67) blocked arsenite-induced transformation.	arsenite	184-192	jun proto-oncogene	Mus musculus	88-93
19059425-4	2009	Our results showed that treatment of cells with low dose arsenite induced activation of c-Jun/AP-1 pathway, and ectopic expression of dominant negative mutant of c-Jun (TAM67) blocked arsenite-induced transformation.	arsenite	184-192	jun proto-oncogene	Mus musculus	162-167
19059425-5	2009	Furthermore, our data indicated that cyclin D1 was an important downstream molecule involved in c-Jun/AP-1-mediated cell transformation upon low dose arsenite exposure, because inhibition of cyclin D1 expression by its specific siRNA in the JB6 Cl41 cells resulted in impairment of anchorage-independent growth of cells induced by low dose arsenite.	arsenite	150-158	cyclin D1	Mus musculus	37-46
19059425-5	2009	Furthermore, our data indicated that cyclin D1 was an important downstream molecule involved in c-Jun/AP-1-mediated cell transformation upon low dose arsenite exposure, because inhibition of cyclin D1 expression by its specific siRNA in the JB6 Cl41 cells resulted in impairment of anchorage-independent growth of cells induced by low dose arsenite.	arsenite	150-158	jun proto-oncogene	Mus musculus	96-101
19059425-5	2009	Furthermore, our data indicated that cyclin D1 was an important downstream molecule involved in c-Jun/AP-1-mediated cell transformation upon low dose arsenite exposure, because inhibition of cyclin D1 expression by its specific siRNA in the JB6 Cl41 cells resulted in impairment of anchorage-independent growth of cells induced by low dose arsenite.	arsenite	150-158	cyclin D1	Mus musculus	191-200
19059425-5	2009	Furthermore, our data indicated that cyclin D1 was an important downstream molecule involved in c-Jun/AP-1-mediated cell transformation upon low dose arsenite exposure, because inhibition of cyclin D1 expression by its specific siRNA in the JB6 Cl41 cells resulted in impairment of anchorage-independent growth of cells induced by low dose arsenite.	arsenite	340-348	cyclin D1	Mus musculus	37-46
19059425-5	2009	Furthermore, our data indicated that cyclin D1 was an important downstream molecule involved in c-Jun/AP-1-mediated cell transformation upon low dose arsenite exposure, because inhibition of cyclin D1 expression by its specific siRNA in the JB6 Cl41 cells resulted in impairment of anchorage-independent growth of cells induced by low dose arsenite.	arsenite	340-348	jun proto-oncogene	Mus musculus	96-101
19059425-6	2009	Collectively, our results demonstrate that c-Jun/AP-1-mediated cyclin D1 expression is at least one of the key events implicated in cell transformation upon low dose arsenite exposure.	arsenite	166-174	jun proto-oncogene	Mus musculus	43-48
19059425-6	2009	Collectively, our results demonstrate that c-Jun/AP-1-mediated cyclin D1 expression is at least one of the key events implicated in cell transformation upon low dose arsenite exposure.	arsenite	166-174	cyclin D1	Mus musculus	63-72
18478230-0	2009	ASNA1, an ATPase targeting tail-anchored proteins, regulates melanoma cell growth and sensitivity to cisplatin and arsenite.	arsenite	115-123	guided entry of tail-anchored proteins factor 3, ATPase	Homo sapiens	0-5
18478230-0	2009	ASNA1, an ATPase targeting tail-anchored proteins, regulates melanoma cell growth and sensitivity to cisplatin and arsenite.	arsenite	115-123	dynein axonemal heavy chain 8	Homo sapiens	10-16
18478230-1	2009	PURPOSE: ASNA1 is homologous to E. coli ArsA, a well characterized ATPase involved in efflux of arsenite and antimonite.	arsenite	96-104	guided entry of tail-anchored proteins factor 3, ATPase	Homo sapiens	9-14
18478230-1	2009	PURPOSE: ASNA1 is homologous to E. coli ArsA, a well characterized ATPase involved in efflux of arsenite and antimonite.	arsenite	96-104	ATPase	Escherichia coli	67-73
18478230-4	2009	The aim of this study was to determine if altered ASNA1 levels influenced growth and sensitivity to arsenite and cisplatin in human melanoma cells.	arsenite	100-108	guided entry of tail-anchored proteins factor 3, ATPase	Homo sapiens	50-55
18478230-12	2009	CONCLUSIONS: Reduced ASNA1 expression is associated with significant inhibition of cell growth, increased apoptosis and increased sensitivity to cisplatin and arsenite.	arsenite	159-167	guided entry of tail-anchored proteins factor 3, ATPase	Homo sapiens	21-26
19073175-4	2009	CCAR1, caprin-1 and AKAP350A along with G3BP, a stress granule marker, relocate to RNA stress granules after arsenite treatment.	arsenite	109-117	cell division cycle and apoptosis regulator 1	Homo sapiens	0-5
19073175-4	2009	CCAR1, caprin-1 and AKAP350A along with G3BP, a stress granule marker, relocate to RNA stress granules after arsenite treatment.	arsenite	109-117	cell cycle associated protein 1	Homo sapiens	7-15
19073175-4	2009	CCAR1, caprin-1 and AKAP350A along with G3BP, a stress granule marker, relocate to RNA stress granules after arsenite treatment.	arsenite	109-117	A-kinase anchoring protein 9	Homo sapiens	20-27
19073175-4	2009	CCAR1, caprin-1 and AKAP350A along with G3BP, a stress granule marker, relocate to RNA stress granules after arsenite treatment.	arsenite	109-117	G3BP stress granule assembly factor 1	Homo sapiens	40-44
19073175-7	2009	In the presence of nocodazole, arsenite induced smaller granules with the vast majority of AKAP350A and CCAR1 separated from G3BP-containing granules.	arsenite	31-39	cell division cycle and apoptosis regulator 1	Homo sapiens	104-109
19073175-7	2009	In the presence of nocodazole, arsenite induced smaller granules with the vast majority of AKAP350A and CCAR1 separated from G3BP-containing granules.	arsenite	31-39	G3BP stress granule assembly factor 1	Homo sapiens	125-129
19073175-8	2009	Similar to nocodazole treatment, reduction of AKAP350A or CCAR1 expression also altered the size and number of G3BP-containing stress granules induced by arsenite treatment.	arsenite	154-162	cell division cycle and apoptosis regulator 1	Homo sapiens	58-63
19073175-8	2009	Similar to nocodazole treatment, reduction of AKAP350A or CCAR1 expression also altered the size and number of G3BP-containing stress granules induced by arsenite treatment.	arsenite	154-162	G3BP stress granule assembly factor 1	Homo sapiens	111-115
18715270-4	2009	Furthermore, melatonin inhibited arsenite-induced phosphorylation of p38 and DNA fragmentation.	arsenite	33-41	mitogen-activated protein kinase 14	Homo sapiens	69-72
18779381-5	2009	Using an FRT-based recombination approach, we created lines harboring small, overlapping deficiencies within this region and found that relative arsenite sensitivity arose when the dose of the glutathione synthetase (GS) gene (located at 16F1) was reduced by half.	arsenite	145-153	glutathione synthetase	Homo sapiens	193-215
18779381-6	2009	Knockdown of GS expression by RNA interference (RNAi) in cultured S2 cells led to enhanced arsenite sensitivity, while GS RNAi applied to intact organisms dramatically reduced the concentration of food-borne arsenite compatible with successful growth and development.	arsenite	91-99	glutathione synthetase	Homo sapiens	13-15
19026558-1	2009	Expression of interleukin-1 receptor type II (IL1R2), a decoy receptor for pro-inflammatory interleukin 1 (IL-1), is enhanced by chronic exposure of the human uroepithelial cell line HUC-1 to arsenite.	arsenite	192-200	interleukin 1 receptor type 2	Homo sapiens	14-44
19026558-1	2009	Expression of interleukin-1 receptor type II (IL1R2), a decoy receptor for pro-inflammatory interleukin 1 (IL-1), is enhanced by chronic exposure of the human uroepithelial cell line HUC-1 to arsenite.	arsenite	192-200	interleukin 1 receptor type 2	Homo sapiens	46-51
19026558-1	2009	Expression of interleukin-1 receptor type II (IL1R2), a decoy receptor for pro-inflammatory interleukin 1 (IL-1), is enhanced by chronic exposure of the human uroepithelial cell line HUC-1 to arsenite.	arsenite	192-200	interleukin 1 alpha	Homo sapiens	75-111
19411561-0	2009	Expression of AS3MT alters transcriptional profiles in human urothelial cells exposed to arsenite.	arsenite	89-97	arsenite methyltransferase	Homo sapiens	14-19
19411561-3	2009	We have shown that clonal human urothelial cells (UROtsa/F35) that express rat AS3MT and methylate iAs are more susceptible to acute toxicity of arsenite (iAs(III)) than parental UROtsa cells that do not express AS3MT and do not methylate iAs.	arsenite	145-153	arsenite methyltransferase	Rattus norvegicus	79-84
18633435-0	2009	Arsenite suppresses Notch1 signaling in human keratinocytes.	arsenite	0-8	notch receptor 1	Homo sapiens	20-26
18633435-2	2009	In this work using cultured human epidermal cells, arsenite suppressed accumulation of the transcriptionally active intracellular domain of Notch1.	arsenite	51-59	notch receptor 1	Homo sapiens	140-146
18633435-4	2009	Arsenite suppressed Jagged1 effects and expression of Jagged1 mRNA as well.	arsenite	0-8	jagged canonical Notch ligand 1	Homo sapiens	20-27
18633435-4	2009	Arsenite suppressed Jagged1 effects and expression of Jagged1 mRNA as well.	arsenite	0-8	jagged canonical Notch ligand 1	Homo sapiens	54-61
18633435-5	2009	Moreover, exposure of the cells to a gamma-secretase inhibitor prevented Notch1 processing, decreased cell size and differentiation marker expression, and increased proliferative potential, all effects that occur with arsenite treatment.	arsenite	218-226	notch receptor 1	Homo sapiens	73-79
18633435-6	2009	Thus, arsenite action in suppressing keratinocyte differentiation while maintaining germinative capability could be due to inhibition of Notch1 signaling subsequent to ligand binding.	arsenite	6-14	notch receptor 1	Homo sapiens	137-143
18633435-8	2009	These findings may help to explain how arsenite, by decreasing generation of the tumor suppressor Notch1, contributes to skin carcinogenesis.	arsenite	39-47	notch receptor 1	Homo sapiens	98-104
19170760-6	2009	When cells were treated with agents, puromycin, sorbitol or arsenite, which induced the formation of stress granules (SGs), cytoplasmic aggregates of stalled translational pre-initiation complexes, both hnRNP K and RBM42 localized at SGs.	arsenite	60-68	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	203-210
19170760-6	2009	When cells were treated with agents, puromycin, sorbitol or arsenite, which induced the formation of stress granules (SGs), cytoplasmic aggregates of stalled translational pre-initiation complexes, both hnRNP K and RBM42 localized at SGs.	arsenite	60-68	RNA binding motif protein 42	Homo sapiens	215-220
19217550-2	2009	Bacterial As(V) reduction can cause arsenic extraction from the solid to the liquid phase because arsenite, As(III), is much less adsorptive than As(V).	arsenite	98-106	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	10-15
19029297-0	2009	NIP1;1, an aquaporin homolog, determines the arsenite sensitivity of Arabidopsis thaliana.	arsenite	45-53	NOD26-like major intrinsic protein 1	Arabidopsis thaliana	0-6
18715270-6	2009	In the ER pathway, melatonin suppressed arsenite-induced elevation in activating transcription factor-6 and CCAAT/enhancer-binding protein homologous protein in the nuclear fraction of the treated DRG explants.	arsenite	40-48	transcription factor A, mitochondrial	Homo sapiens	81-103
18715270-8	2009	In the mitochondrial pathway, arsenite-induced increases in Bcl-2 levels and cytosolic cytochrome c were reduced by melatonin.	arsenite	30-38	BCL2 apoptosis regulator	Homo sapiens	60-65
18715270-8	2009	In the mitochondrial pathway, arsenite-induced increases in Bcl-2 levels and cytosolic cytochrome c were reduced by melatonin.	arsenite	30-38	cytochrome c, somatic	Homo sapiens	87-99
18715270-9	2009	At the same time, melatonin inhibited arsenite-induced activation of caspase 3 in the treated DRG explants.	arsenite	38-46	caspase 3	Homo sapiens	69-78
18936160-8	2009	In HEK293T and HeLa cells, arsenite, peroxide, and serum starvation-mediated stresses dissociated the TRBP-PACT interaction and increased PACT-induced PKR activation, demonstrating the relevance of this control in a physiological context.	arsenite	27-35	TARBP2 pseudogene 1	Homo sapiens	102-106
18936160-8	2009	In HEK293T and HeLa cells, arsenite, peroxide, and serum starvation-mediated stresses dissociated the TRBP-PACT interaction and increased PACT-induced PKR activation, demonstrating the relevance of this control in a physiological context.	arsenite	27-35	protein activator of interferon induced protein kinase EIF2AK2	Homo sapiens	107-111
18936160-8	2009	In HEK293T and HeLa cells, arsenite, peroxide, and serum starvation-mediated stresses dissociated the TRBP-PACT interaction and increased PACT-induced PKR activation, demonstrating the relevance of this control in a physiological context.	arsenite	27-35	protein activator of interferon induced protein kinase EIF2AK2	Homo sapiens	138-142
18936160-8	2009	In HEK293T and HeLa cells, arsenite, peroxide, and serum starvation-mediated stresses dissociated the TRBP-PACT interaction and increased PACT-induced PKR activation, demonstrating the relevance of this control in a physiological context.	arsenite	27-35	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	151-154
19274090-4	2009	Specifically, eIF4G was cleaved by expression of the poliovirus 2A protease (2A(pro)) and the alpha subunit of eIF2 was inactivated by phosphorylation induced by arsenite treatment.	arsenite	162-170	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	14-19
19064914-9	2008	(iii) Unexpectedly, loss of PRDX-2 increases the resistance of C. elegans to some oxidative stress-causing agents, such as arsenite, apparently through a signaling mechanism that increases the levels of other antioxidants and phase II detoxification enzymes.	arsenite	123-131	Peroxiredoxin prdx-2	Caenorhabditis elegans	28-34
18976679-1	2009	Human arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite, and intronic single-nucleotide polymorphisms (SNPs: G7395A, G12390C, T14215C, T35587C, and G35991A) in the AS3MT gene were shown to be related to inter-individual variation in the arsenic metabolism.	arsenite	101-109	arsenite methyltransferase	Homo sapiens	6-52
18976679-1	2009	Human arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite, and intronic single-nucleotide polymorphisms (SNPs: G7395A, G12390C, T14215C, T35587C, and G35991A) in the AS3MT gene were shown to be related to inter-individual variation in the arsenic metabolism.	arsenite	101-109	arsenite methyltransferase	Homo sapiens	54-59
18929588-4	2008	In this study, we found that arsenite (As(3+)) induced apoptosis and cell cycle arrest in a dose-dependent manner in both p53(+/+) and p53(-/-) mouse embryonic fibroblasts (MEFs).	arsenite	29-37	transformation related protein 53, pseudogene	Mus musculus	122-125
18929588-4	2008	In this study, we found that arsenite (As(3+)) induced apoptosis and cell cycle arrest in a dose-dependent manner in both p53(+/+) and p53(-/-) mouse embryonic fibroblasts (MEFs).	arsenite	29-37	transformation related protein 53, pseudogene	Mus musculus	135-138
19033667-2	2008	We found that the addition of low doses of arsenite to the drinking water of mice resulted in marked pathologic remodeling in liver sinusoidal endothelial cells (SECs), including SEC defenestration, capillarization, increased junctional PECAM-1 expression, protein nitration, and decreased liver clearance of modified albumin.	arsenite	43-51	platelet/endothelial cell adhesion molecule 1	Mus musculus	237-244
18621123-4	2008	The current study demonstrates that low concentrations of arsenite (As(III)) inhibit UVR-induced CPD repair in a human keratinocyte cell line via nitric oxide (NO) and inducible nitric oxide synthase (iNOS).	arsenite	58-66	nitric oxide synthase 2	Homo sapiens	168-199
19010883-3	2008	Through the mitogen-activated protein kinase pathway, arsenite stimulates the P2 promoter-mediated expression of Hdm2, which then promotes p53 nuclear export.	arsenite	54-62	MDM2 proto-oncogene	Homo sapiens	113-117
18762312-1	2008	In this study, denitrification linked to the oxidation of arsenite (As(III)) to arsenate (As(V)) was shown to be a widespread microbial activity in anaerobic sludge and sediment samples that were not previously exposed to arsenic contamination.	arsenite	58-66	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	90-95
19010883-3	2008	Through the mitogen-activated protein kinase pathway, arsenite stimulates the P2 promoter-mediated expression of Hdm2, which then promotes p53 nuclear export.	arsenite	54-62	tumor protein p53	Homo sapiens	139-142
19010883-5	2008	The ability of arsenite to impede p53 activation is further demonstrated by a significantly blunted p53-dependent tissue response to 5FU treatment when mice were fed with arsenite-containing water.	arsenite	15-23	transformation related protein 53, pseudogene	Mus musculus	34-37
19010883-5	2008	The ability of arsenite to impede p53 activation is further demonstrated by a significantly blunted p53-dependent tissue response to 5FU treatment when mice were fed with arsenite-containing water.	arsenite	15-23	transformation related protein 53, pseudogene	Mus musculus	100-103
19010883-5	2008	The ability of arsenite to impede p53 activation is further demonstrated by a significantly blunted p53-dependent tissue response to 5FU treatment when mice were fed with arsenite-containing water.	arsenite	171-179	transformation related protein 53, pseudogene	Mus musculus	34-37
19010883-5	2008	The ability of arsenite to impede p53 activation is further demonstrated by a significantly blunted p53-dependent tissue response to 5FU treatment when mice were fed with arsenite-containing water.	arsenite	171-179	transformation related protein 53, pseudogene	Mus musculus	100-103
18621123-4	2008	The current study demonstrates that low concentrations of arsenite (As(III)) inhibit UVR-induced CPD repair in a human keratinocyte cell line via nitric oxide (NO) and inducible nitric oxide synthase (iNOS).	arsenite	58-66	nitric oxide synthase 2	Homo sapiens	201-205
18439143-1	2008	In the budding yeast Saccharomyces cerevisiae, arsenic detoxification involves the activation of Yap8, a member of the Yap (yeast AP-1-like) family of transcription factors, which in turn regulates ACR2 and ACR3, genes encoding an arsenate reductase and a plasma-membrane arsenite-efflux protein respectively.	arsenite	272-280	Arr1p	Saccharomyces cerevisiae S288C	97-101
18991936-5	2008	Arsenite exposure produced a concentration-dependent induction of heme oxygenase-1 (up to eight-fold) and metallothionein-1 (up to five-fold), indicative of stress response to adapt to arsenic insult.	arsenite	0-8	heme oxygenase 1	Mus musculus	66-82
18991936-5	2008	Arsenite exposure produced a concentration-dependent induction of heme oxygenase-1 (up to eight-fold) and metallothionein-1 (up to five-fold), indicative of stress response to adapt to arsenic insult.	arsenite	0-8	metallothionein 1	Mus musculus	106-123
18619636-0	2008	Low concentration of arsenite exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activity.	arsenite	21-29	poly(ADP-ribose) polymerase 1	Homo sapiens	86-92
18619636-9	2008	Further studies showed that 2 microM arsenite effectively inhibited PARP-1 activity.	arsenite	37-45	poly(ADP-ribose) polymerase 1	Homo sapiens	68-74
18619636-10	2008	Zinc supplementation of arsenite-treated cells restored PARP-1 activity and significantly diminished the exacerbating effect of arsenite on UVR-induced DNA strand breaks.	arsenite	24-32	poly(ADP-ribose) polymerase 1	Homo sapiens	56-62
18619636-12	2008	Combination treatments of arsenite with PARP-1 inhibitor 3-aminobenzamide or PARP-1 siRNA demonstrate that PARP-1 is the target of arsenite.	arsenite	131-139	poly(ADP-ribose) polymerase 1	Homo sapiens	40-46
18619636-12	2008	Combination treatments of arsenite with PARP-1 inhibitor 3-aminobenzamide or PARP-1 siRNA demonstrate that PARP-1 is the target of arsenite.	arsenite	131-139	poly(ADP-ribose) polymerase 1	Homo sapiens	77-83
18619636-12	2008	Combination treatments of arsenite with PARP-1 inhibitor 3-aminobenzamide or PARP-1 siRNA demonstrate that PARP-1 is the target of arsenite.	arsenite	131-139	poly(ADP-ribose) polymerase 1	Homo sapiens	77-83
18619636-13	2008	Together, these findings show that arsenite at low concentration exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activity, which may represent an important mechanism underlying the co-carcinogenicity of arsenic.	arsenite	35-43	poly(ADP-ribose) polymerase 1	Homo sapiens	121-127
18707137-8	2008	Zinc supplementation reduced the formation of 8-OHdG, restored the PARP-1 activity inhibited by arsenite, but did not decrease ROS production.	arsenite	96-104	poly(ADP-ribose) polymerase 1	Homo sapiens	67-73
18707137-9	2008	SiRNA knockdown of PARP-1 did not affect the 8-OHdG level induced by arsenic, while it greatly increased the 8-OHdG level produced by hydrogen peroxide indicating that PARP-1 is a molecular target of arsenite.	arsenite	200-208	poly(ADP-ribose) polymerase 1	Homo sapiens	19-25
18707137-9	2008	SiRNA knockdown of PARP-1 did not affect the 8-OHdG level induced by arsenic, while it greatly increased the 8-OHdG level produced by hydrogen peroxide indicating that PARP-1 is a molecular target of arsenite.	arsenite	200-208	poly(ADP-ribose) polymerase 1	Homo sapiens	168-174
18707137-10	2008	Our findings demonstrate that in addition to inducing oxidative stress at higher concentrations, arsenite can also inhibit the function of a key DNA repair protein, PARP-1, even at very low concentrations, thus exacerbating the overall oxidative DNA damage produced by arsenite, and potentially, by other oxidants as well.	arsenite	97-105	X-ray repair cross complementing 6 pseudogene 5	Homo sapiens	145-163
18707137-10	2008	Our findings demonstrate that in addition to inducing oxidative stress at higher concentrations, arsenite can also inhibit the function of a key DNA repair protein, PARP-1, even at very low concentrations, thus exacerbating the overall oxidative DNA damage produced by arsenite, and potentially, by other oxidants as well.	arsenite	97-105	poly(ADP-ribose) polymerase 1	Homo sapiens	165-171
18707137-10	2008	Our findings demonstrate that in addition to inducing oxidative stress at higher concentrations, arsenite can also inhibit the function of a key DNA repair protein, PARP-1, even at very low concentrations, thus exacerbating the overall oxidative DNA damage produced by arsenite, and potentially, by other oxidants as well.	arsenite	269-277	X-ray repair cross complementing 6 pseudogene 5	Homo sapiens	145-163
18707137-10	2008	Our findings demonstrate that in addition to inducing oxidative stress at higher concentrations, arsenite can also inhibit the function of a key DNA repair protein, PARP-1, even at very low concentrations, thus exacerbating the overall oxidative DNA damage produced by arsenite, and potentially, by other oxidants as well.	arsenite	269-277	poly(ADP-ribose) polymerase 1	Homo sapiens	165-171
18597805-0	2008	Arsenite reduces insulin secretion in rat pancreatic beta-cells by decreasing the calcium-dependent calpain-10 proteolysis of SNAP-25.	arsenite	0-8	calpain 10	Rattus norvegicus	100-110
18597805-0	2008	Arsenite reduces insulin secretion in rat pancreatic beta-cells by decreasing the calcium-dependent calpain-10 proteolysis of SNAP-25.	arsenite	0-8	synaptosome associated protein 25	Rattus norvegicus	126-133
18597805-7	2008	However, during the secretion of insulin stimulated with glucose (15.6 mM), 1 microM arsenite decreased the activity of calpain-10, measured as SNAP-25 proteolysis.	arsenite	85-93	calpain 10	Rattus norvegicus	120-130
18597805-7	2008	However, during the secretion of insulin stimulated with glucose (15.6 mM), 1 microM arsenite decreased the activity of calpain-10, measured as SNAP-25 proteolysis.	arsenite	85-93	synaptosome associated protein 25	Rattus norvegicus	144-151
18597805-10	2008	Data obtained showed that one of the mechanisms by which arsenite impairs insulin secretion is by decreasing the oscillations of free [Ca(2+)]i, thus reducing calcium-dependent calpain-10 partial proteolysis of SNAP-25.	arsenite	57-65	calpain 10	Rattus norvegicus	177-187
18597805-10	2008	Data obtained showed that one of the mechanisms by which arsenite impairs insulin secretion is by decreasing the oscillations of free [Ca(2+)]i, thus reducing calcium-dependent calpain-10 partial proteolysis of SNAP-25.	arsenite	57-65	synaptosome associated protein 25	Rattus norvegicus	211-218
18707137-3	2008	The present study tests the hypothesis that arsenite not only induces oxidative stress but also inhibits the activity of the DNA base excision repair protein, poly(ADP-ribose) polymerase-1 (PARP-1), leading to exacerbation of the oxidative DNA damage induced by arsenic.	arsenite	44-52	poly(ADP-ribose) polymerase 1	Homo sapiens	159-188
18707137-3	2008	The present study tests the hypothesis that arsenite not only induces oxidative stress but also inhibits the activity of the DNA base excision repair protein, poly(ADP-ribose) polymerase-1 (PARP-1), leading to exacerbation of the oxidative DNA damage induced by arsenic.	arsenite	44-52	poly(ADP-ribose) polymerase 1	Homo sapiens	190-196
18707137-7	2008	At lower concentrations (1 microM), arsenite did not produce detectable 8-OHdG, but was still able to effectively inhibit PARP-1 activity.	arsenite	36-44	poly(ADP-ribose) polymerase 1	Homo sapiens	122-128
18572023-7	2008	In contrast to increased basal Nrf2 activity in As-TM cells, a diminished Nrf2-mediated antioxidant response induced by acute exposure to high doses of arsenite or tert-butyl hydroxyquinone occurred.	arsenite	152-160	NFE2 like bZIP transcription factor 2	Homo sapiens	74-78
18505831-10	2008	Results from our study suggest that sodium arsenite induces SHP via AMPK to inhibit the expression of hepatic gluconeogenic genes and also provide us with a novel molecular mechanism of arsenite-mediated regulation of hepatic glucose homeostasis.	arsenite	43-51	nuclear receptor subfamily 0 group B member 2	Homo sapiens	60-63
18550526-0	2008	BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite.	arsenite	62-70	BTB domain and CNC homolog 1	Homo sapiens	0-5
18550526-0	2008	BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite.	arsenite	62-70	heme oxygenase 1	Homo sapiens	33-38
18550526-6	2008	We show that BACH1 is inactivated at low micromolar arsenite concentrations and that BACH1 inactivation is necessary and sufficient for transcriptional induction of HMOX1.	arsenite	52-60	BTB domain and CNC homolog 1	Homo sapiens	13-18
18550526-6	2008	We show that BACH1 is inactivated at low micromolar arsenite concentrations and that BACH1 inactivation is necessary and sufficient for transcriptional induction of HMOX1.	arsenite	52-60	heme oxygenase 1	Homo sapiens	165-170
18505831-5	2008	The arsenite-induced SHP mRNA level was blocked by adenoviral overexpression of dominant negative AMPK (Ad-dnAMPKalpha) or by the AMPK inhibitor compound C in hepatic cell lines.	arsenite	4-12	nuclear receptor subfamily 0 group B member 2	Homo sapiens	21-24
18505831-5	2008	The arsenite-induced SHP mRNA level was blocked by adenoviral overexpression of dominant negative AMPK (Ad-dnAMPKalpha) or by the AMPK inhibitor compound C in hepatic cell lines.	arsenite	4-12	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	98-102
18505831-5	2008	The arsenite-induced SHP mRNA level was blocked by adenoviral overexpression of dominant negative AMPK (Ad-dnAMPKalpha) or by the AMPK inhibitor compound C in hepatic cell lines.	arsenite	4-12	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	109-113
18501396-2	2008	Our previous studies indicated that decreased arsenite sensitivity correlated with reduced mitotic spindle checkpoint function and reduced expression of the checkpoint protein BUBR1.	arsenite	46-54	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	176-181
18501396-3	2008	In the current study, arsenite induced securin and cyclin B stabilization, BUBR1 phosphorylation, and spindle checkpoint activation.	arsenite	22-30	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	39-46
18501396-3	2008	In the current study, arsenite induced securin and cyclin B stabilization, BUBR1 phosphorylation, and spindle checkpoint activation.	arsenite	22-30	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	75-80
18501396-4	2008	Arsenite also increased activating cyclin dependent kinase 1 (CDK1) Thr(161) phosphorylation but decreased inhibitory Tyr15 phosphorylation.	arsenite	0-8	cyclin dependent kinase 1	Homo sapiens	35-60
18501396-4	2008	Arsenite also increased activating cyclin dependent kinase 1 (CDK1) Thr(161) phosphorylation but decreased inhibitory Tyr15 phosphorylation.	arsenite	0-8	cyclin dependent kinase 1	Homo sapiens	62-66
18501396-7	2008	Inhibition of CDK1 with roscovitine in arsenite-treated mitotic cells inhibited spindle checkpoint maintenance as inferred from reduced BUBR1 phosphorylation, reduced cyclin B expression, and diminution of mitotic index.	arsenite	39-47	cyclin dependent kinase 1	Homo sapiens	14-18
18501396-7	2008	Inhibition of CDK1 with roscovitine in arsenite-treated mitotic cells inhibited spindle checkpoint maintenance as inferred from reduced BUBR1 phosphorylation, reduced cyclin B expression, and diminution of mitotic index.	arsenite	39-47	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	136-141
18501396-9	2008	In addition, suppression of BUBR1 with siRNA prevented arsenite-induced mitotic arrest and apoptosis.	arsenite	55-63	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	28-33
18157586-0	2008	Identification and characterisation of arsenite (+3 Oxidation State) methyltransferase (AS3MT) in mouse neuroblastoma cell line N1E-115.	arsenite	39-47	arsenite methyltransferase	Mus musculus	88-93
18505831-7	2008	Ad-dnAMPKalpha blocked the repressive effects of arsenite-induced SHP on PEPCK and G6Pase.	arsenite	49-57	nuclear receptor subfamily 0 group B member 2	Homo sapiens	66-69
18505831-7	2008	Ad-dnAMPKalpha blocked the repressive effects of arsenite-induced SHP on PEPCK and G6Pase.	arsenite	49-57	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	73-78
18505831-7	2008	Ad-dnAMPKalpha blocked the repressive effects of arsenite-induced SHP on PEPCK and G6Pase.	arsenite	49-57	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	83-89
18505831-10	2008	Results from our study suggest that sodium arsenite induces SHP via AMPK to inhibit the expression of hepatic gluconeogenic genes and also provide us with a novel molecular mechanism of arsenite-mediated regulation of hepatic glucose homeostasis.	arsenite	43-51	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	68-72
18552285-0	2008	Mitogen-activated protein kinase Hog1 mediates adaptation to G1 checkpoint arrest during arsenite and hyperosmotic stress.	arsenite	89-97	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	33-37
18597494-7	2008	These results suggest that arsenite-induced apoptosis occurs independently of p53/ cep-1 and the DNA damage response (DDR) genes hus-1, clk-2, and egl-1 and that the C. elegans caspase gene ced-3, Apaf-1 homologue ced-4, and the MAPK signaling pathways are essential for germline apoptosis.	arsenite	27-35	Telomere length regulation protein clk-2	Caenorhabditis elegans	136-141
18597494-7	2008	These results suggest that arsenite-induced apoptosis occurs independently of p53/ cep-1 and the DNA damage response (DDR) genes hus-1, clk-2, and egl-1 and that the C. elegans caspase gene ced-3, Apaf-1 homologue ced-4, and the MAPK signaling pathways are essential for germline apoptosis.	arsenite	27-35	Programmed cell death activator egl-1	Caenorhabditis elegans	147-152
18597494-7	2008	These results suggest that arsenite-induced apoptosis occurs independently of p53/ cep-1 and the DNA damage response (DDR) genes hus-1, clk-2, and egl-1 and that the C. elegans caspase gene ced-3, Apaf-1 homologue ced-4, and the MAPK signaling pathways are essential for germline apoptosis.	arsenite	27-35	Cell death protein 4	Caenorhabditis elegans	214-219
18476811-4	2008	Phosphorylation of Ago2 at serine-387 was significantly induced by treatment with sodium arsenite or anisomycin, and arsenite-induced phosphorylation was inhibited by a p38 MAPK (mitogen-activated protein kinase) inhibitor, but not by inhibitors of JNK (c-Jun N-terminal kinase) or MEK [MAPK/ERK (extracellular-signal-regulated kinase) kinase].	arsenite	89-97	argonaute RISC catalytic component 2	Homo sapiens	19-23
18550147-7	2008	In all the systems, a high concentration of As(V) was found under reducing conditions, indicating that the chemical kinetics for the conversion of arsenate to arsenite is slow.	arsenite	159-167	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	44-49
18552285-8	2008	Moreover, the Sic1 protein was stabilized in arsenite-treated hog1Delta cells.	arsenite	45-53	cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1	Saccharomyces cerevisiae S288C	14-18
18552285-8	2008	Moreover, the Sic1 protein was stabilized in arsenite-treated hog1Delta cells.	arsenite	45-53	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	62-66
18529053-1	2008	The binding of arsenite (As(III)) and monomethylarsenite (MMAIII) to the DNA-binding domain of the glucocorticoid receptor (GR-DBD) and their competition with the two required Zn2+ ions of this domain have been investigated with isothermal titration calorimetry (ITC) and circular dichroism (CD).	arsenite	15-23	nuclear receptor subfamily 3 group C member 1	Homo sapiens	99-122
18417180-0	2008	Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction.	arsenite	22-30	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
18474416-0	2008	Arsenite and cadmium, but not chromium, induce NAD(P)H:quinone oxidoreductase 1 through transcriptional mechanisms, in spite of post-transcriptional modifications.	arsenite	0-8	NAD(P)H dehydrogenase, quinone 1	Mus musculus	47-79
18485433-9	2008	Of the three drugs tested, only arsenite treatment increased expression of the inducible isoform of heat shock protein 70 (HSP70i).	arsenite	32-40	heat shock protein family A (Hsp70) member 1A	Homo sapiens	123-129
18485433-11	2008	HSP90 inhibitor 17-DMAG sensitized cells to arsenite treatment and increased arsenite-induced centrosome abnormalities.	arsenite	44-52	heat shock protein 90 alpha family class A member 1	Homo sapiens	0-5
18485433-11	2008	HSP90 inhibitor 17-DMAG sensitized cells to arsenite treatment and increased arsenite-induced centrosome abnormalities.	arsenite	77-85	heat shock protein 90 alpha family class A member 1	Homo sapiens	0-5
18485433-13	2008	Thus, arsenite-induced abnormal centrosome amplification and subsequent mitotic arrest is independent of effects on tubulin polymerization and may be due to specific stresses that are protected against by HSP90 and HSP70.	arsenite	6-14	heat shock protein 90 alpha family class A member 1	Homo sapiens	205-210
18485433-13	2008	Thus, arsenite-induced abnormal centrosome amplification and subsequent mitotic arrest is independent of effects on tubulin polymerization and may be due to specific stresses that are protected against by HSP90 and HSP70.	arsenite	6-14	heat shock protein family A (Hsp70) member 4	Homo sapiens	215-220
18508047-0	2008	Both IKKalpha and IKKbeta are implicated in the arsenite-induced AP-1 transactivation correlating with cell apoptosis through NF-kappaB activity-independent manner.	arsenite	48-56	conserved helix-loop-helix ubiquitous kinase	Mus musculus	5-13
18508047-0	2008	Both IKKalpha and IKKbeta are implicated in the arsenite-induced AP-1 transactivation correlating with cell apoptosis through NF-kappaB activity-independent manner.	arsenite	48-56	inhibitor of kappaB kinase beta	Mus musculus	18-25
18508047-7	2008	Therefore, we concluded that both IKKalpha and IKKbeta can mediate arsenite-induced AP-1 transactivation through NF-kappaB activity-independent manner.	arsenite	67-75	inhibitor of kappaB kinase beta	Mus musculus	47-54
18508047-7	2008	Therefore, we concluded that both IKKalpha and IKKbeta can mediate arsenite-induced AP-1 transactivation through NF-kappaB activity-independent manner.	arsenite	67-75	jun proto-oncogene	Mus musculus	84-88
18508047-0	2008	Both IKKalpha and IKKbeta are implicated in the arsenite-induced AP-1 transactivation correlating with cell apoptosis through NF-kappaB activity-independent manner.	arsenite	48-56	jun proto-oncogene	Mus musculus	65-69
18508047-2	2008	AP-1 is one of the transcription factors that can be induced upon arsenite stimulation.	arsenite	66-74	jun proto-oncogene	Mus musculus	0-4
18508047-3	2008	However, the study on the mechanism and the function of the arsenite-induced AP-1 transactivation remains far complete.	arsenite	60-68	jun proto-oncogene	Mus musculus	77-81
18508047-4	2008	Here we demonstrated that high dose of arsenite induced apoptotic response in mouse fibroblasts correlating with AP-1 transactivation, which events were mediated by both IKKalpha and IKKbeta, two major protein kinases responsible for NF-kappaB activation.	arsenite	39-47	jun proto-oncogene	Mus musculus	113-117
18508047-4	2008	Here we demonstrated that high dose of arsenite induced apoptotic response in mouse fibroblasts correlating with AP-1 transactivation, which events were mediated by both IKKalpha and IKKbeta, two major protein kinases responsible for NF-kappaB activation.	arsenite	39-47	conserved helix-loop-helix ubiquitous kinase	Mus musculus	170-178
18508047-4	2008	Here we demonstrated that high dose of arsenite induced apoptotic response in mouse fibroblasts correlating with AP-1 transactivation, which events were mediated by both IKKalpha and IKKbeta, two major protein kinases responsible for NF-kappaB activation.	arsenite	39-47	inhibitor of kappaB kinase beta	Mus musculus	183-190
18508047-5	2008	In addition, the regulatory effect of IKKs on the arsenite-induced AP-1 activation was delivered by sequential induction of GADD45alpha expression and the activation of MAPKK (MKK3/4/6) and MAPK (JNK and p38K)-dependent pathways.	arsenite	50-58	jun proto-oncogene	Mus musculus	67-71
18508047-5	2008	In addition, the regulatory effect of IKKs on the arsenite-induced AP-1 activation was delivered by sequential induction of GADD45alpha expression and the activation of MAPKK (MKK3/4/6) and MAPK (JNK and p38K)-dependent pathways.	arsenite	50-58	growth arrest and DNA-damage-inducible 45 alpha	Mus musculus	124-135
18508047-6	2008	We further provided evidence that p50, but not p65 subunit of NF-kappaB, was involved in GADD45alpha induction and the subsequent MAPKK/MAPK/AP-1 activation under arsenite exposure, while functional NF-kappaB induced by arsenite stimulation consisted of p65 but not of p50 subunit.	arsenite	163-171	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	34-37
18508047-6	2008	We further provided evidence that p50, but not p65 subunit of NF-kappaB, was involved in GADD45alpha induction and the subsequent MAPKK/MAPK/AP-1 activation under arsenite exposure, while functional NF-kappaB induced by arsenite stimulation consisted of p65 but not of p50 subunit.	arsenite	163-171	growth arrest and DNA-damage-inducible 45 alpha	Mus musculus	89-100
18508047-6	2008	We further provided evidence that p50, but not p65 subunit of NF-kappaB, was involved in GADD45alpha induction and the subsequent MAPKK/MAPK/AP-1 activation under arsenite exposure, while functional NF-kappaB induced by arsenite stimulation consisted of p65 but not of p50 subunit.	arsenite	163-171	jun proto-oncogene	Mus musculus	141-145
18508047-6	2008	We further provided evidence that p50, but not p65 subunit of NF-kappaB, was involved in GADD45alpha induction and the subsequent MAPKK/MAPK/AP-1 activation under arsenite exposure, while functional NF-kappaB induced by arsenite stimulation consisted of p65 but not of p50 subunit.	arsenite	163-171	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	254-257
18508047-6	2008	We further provided evidence that p50, but not p65 subunit of NF-kappaB, was involved in GADD45alpha induction and the subsequent MAPKK/MAPK/AP-1 activation under arsenite exposure, while functional NF-kappaB induced by arsenite stimulation consisted of p65 but not of p50 subunit.	arsenite	163-171	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	269-272
18508047-6	2008	We further provided evidence that p50, but not p65 subunit of NF-kappaB, was involved in GADD45alpha induction and the subsequent MAPKK/MAPK/AP-1 activation under arsenite exposure, while functional NF-kappaB induced by arsenite stimulation consisted of p65 but not of p50 subunit.	arsenite	220-228	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	34-37
18508047-7	2008	Therefore, we concluded that both IKKalpha and IKKbeta can mediate arsenite-induced AP-1 transactivation through NF-kappaB activity-independent manner.	arsenite	67-75	conserved helix-loop-helix ubiquitous kinase	Mus musculus	34-42
18465250-6	2008	RNAi knock down of FOXO3a inhibited Bim promoter activity, Bim(EL) protein expression, and arsenite-induced apoptosis.	arsenite	91-99	forkhead box O3	Rattus norvegicus	19-25
18465250-0	2008	p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription.	arsenite	24-32	mitogen activated protein kinase 14	Rattus norvegicus	0-3
18629308-0	2008	A novel role of the NRF2 transcription factor in the regulation of arsenite-mediated keratin 16 gene expression in human keratinocytes.	arsenite	67-75	NFE2 like bZIP transcription factor 2	Homo sapiens	20-24
18629308-0	2008	A novel role of the NRF2 transcription factor in the regulation of arsenite-mediated keratin 16 gene expression in human keratinocytes.	arsenite	67-75	keratin 16	Homo sapiens	85-95
18604262-5	2008	Licorice (0.1 and 1.0 mg ml(-1)) treatment significantly inhibited cell death and the activity of caspase-3 in response to As exposure.	arsenite	123-125	caspase 3	Rattus norvegicus	98-107
18465250-0	2008	p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription.	arsenite	24-32	forkhead box O3	Rattus norvegicus	59-65
18465250-0	2008	p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription.	arsenite	24-32	Bcl2-like 11	Rattus norvegicus	94-97
18504176-0	2008	[Construction and expression of different mutants of human p53 and their effects on arsenite-induced cell apoptosis].	arsenite	84-92	tumor protein p53	Homo sapiens	59-62
18328521-4	2008	Inhibition of glutathione synthesis, glutathione S-transferase (GST) activity, and multidrug resistance protein (MRP) transporter function attenuated arsenite resistance, consistent with studies suggesting that arsenite is extruded from the cell as a glutathione conjugate by MRP-1.	arsenite	150-158	ATP binding cassette subfamily C member 1	Homo sapiens	83-111
18328521-4	2008	Inhibition of glutathione synthesis, glutathione S-transferase (GST) activity, and multidrug resistance protein (MRP) transporter function attenuated arsenite resistance, consistent with studies suggesting that arsenite is extruded from the cell as a glutathione conjugate by MRP-1.	arsenite	150-158	ATP binding cassette subfamily C member 1	Homo sapiens	113-116
18328521-4	2008	Inhibition of glutathione synthesis, glutathione S-transferase (GST) activity, and multidrug resistance protein (MRP) transporter function attenuated arsenite resistance, consistent with studies suggesting that arsenite is extruded from the cell as a glutathione conjugate by MRP-1.	arsenite	211-219	glutathione S-transferase kappa 1	Homo sapiens	64-67
18328521-4	2008	Inhibition of glutathione synthesis, glutathione S-transferase (GST) activity, and multidrug resistance protein (MRP) transporter function attenuated arsenite resistance, consistent with studies suggesting that arsenite is extruded from the cell as a glutathione conjugate by MRP-1.	arsenite	211-219	ATP binding cassette subfamily C member 1	Homo sapiens	83-111
18328521-4	2008	Inhibition of glutathione synthesis, glutathione S-transferase (GST) activity, and multidrug resistance protein (MRP) transporter function attenuated arsenite resistance, consistent with studies suggesting that arsenite is extruded from the cell as a glutathione conjugate by MRP-1.	arsenite	211-219	ATP binding cassette subfamily C member 1	Homo sapiens	113-116
18328521-4	2008	Inhibition of glutathione synthesis, glutathione S-transferase (GST) activity, and multidrug resistance protein (MRP) transporter function attenuated arsenite resistance, consistent with studies suggesting that arsenite is extruded from the cell as a glutathione conjugate by MRP-1.	arsenite	211-219	ATP binding cassette subfamily C member 1	Homo sapiens	276-281
18328521-11	2008	The lack of arsenite-induced mitotic arrest in resistant cell lines was associated with a weakened spindle checkpoint resulting from reduced expression of spindle checkpoint protein BUBR1.	arsenite	12-20	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	182-187
18467495-3	2008	We report that worms lacking aip-1, a homologue of mammalian AIRAP (arsenic-inducible proteasomal 19S regulatory particle-associated protein), are not only impaired in their ability to resist exposure to arsenite but also exhibit shortened lifespan and hypersensitivity to misfolding-prone proteins under normal laboratory conditions.	arsenite	204-212	DAB2 interacting protein	Homo sapiens	29-34
18467495-3	2008	We report that worms lacking aip-1, a homologue of mammalian AIRAP (arsenic-inducible proteasomal 19S regulatory particle-associated protein), are not only impaired in their ability to resist exposure to arsenite but also exhibit shortened lifespan and hypersensitivity to misfolding-prone proteins under normal laboratory conditions.	arsenite	204-212	zinc finger AN1-type containing 2A	Homo sapiens	68-140
18467495-5	2008	Genetic rescue experiments suggest that features common to the constitutively expressed worm AIP-1 and mammalian AIRAPL (but missing in the smaller, arsenite-inducible AIRAP) are important to lifespan extension.	arsenite	149-157	DAB2 interacting protein	Homo sapiens	93-98
18467495-5	2008	Genetic rescue experiments suggest that features common to the constitutively expressed worm AIP-1 and mammalian AIRAPL (but missing in the smaller, arsenite-inducible AIRAP) are important to lifespan extension.	arsenite	149-157	zinc finger AN1-type containing 2B	Homo sapiens	113-119
18467495-5	2008	Genetic rescue experiments suggest that features common to the constitutively expressed worm AIP-1 and mammalian AIRAPL (but missing in the smaller, arsenite-inducible AIRAP) are important to lifespan extension.	arsenite	149-157	zinc finger AN1-type containing 2A	Homo sapiens	113-118
17849503-4	2008	Investigation of the involvement of GSK3 in arsenite-induced apoptosis demonstrated that arsenite induced apoptosis in SH-SY5Y human neuroblastoma cells, activating the executioner caspase-3 which caused cleavage of poly-ADP ribose-polymerase (PARP).	arsenite	44-52	caspase 3	Homo sapiens	181-190
17849503-4	2008	Investigation of the involvement of GSK3 in arsenite-induced apoptosis demonstrated that arsenite induced apoptosis in SH-SY5Y human neuroblastoma cells, activating the executioner caspase-3 which caused cleavage of poly-ADP ribose-polymerase (PARP).	arsenite	44-52	poly(ADP-ribose) polymerase 1	Homo sapiens	216-242
17849503-4	2008	Investigation of the involvement of GSK3 in arsenite-induced apoptosis demonstrated that arsenite induced apoptosis in SH-SY5Y human neuroblastoma cells, activating the executioner caspase-3 which caused cleavage of poly-ADP ribose-polymerase (PARP).	arsenite	44-52	poly(ADP-ribose) polymerase 1	Homo sapiens	244-248
17849503-4	2008	Investigation of the involvement of GSK3 in arsenite-induced apoptosis demonstrated that arsenite induced apoptosis in SH-SY5Y human neuroblastoma cells, activating the executioner caspase-3 which caused cleavage of poly-ADP ribose-polymerase (PARP).	arsenite	89-97	caspase 3	Homo sapiens	181-190
17849503-4	2008	Investigation of the involvement of GSK3 in arsenite-induced apoptosis demonstrated that arsenite induced apoptosis in SH-SY5Y human neuroblastoma cells, activating the executioner caspase-3 which caused cleavage of poly-ADP ribose-polymerase (PARP).	arsenite	89-97	poly(ADP-ribose) polymerase 1	Homo sapiens	216-242
17849503-4	2008	Investigation of the involvement of GSK3 in arsenite-induced apoptosis demonstrated that arsenite induced apoptosis in SH-SY5Y human neuroblastoma cells, activating the executioner caspase-3 which caused cleavage of poly-ADP ribose-polymerase (PARP).	arsenite	89-97	poly(ADP-ribose) polymerase 1	Homo sapiens	244-248
17849503-5	2008	Two selective GSK3 inhibitors, lithium and SB216763, attenuated caspase-3 activation and PARP cleavage induced by arsenite treatment indicating that GSK3 contributed to arsenite-induced apoptosis.	arsenite	114-122	caspase 3	Homo sapiens	64-73
17849503-5	2008	Two selective GSK3 inhibitors, lithium and SB216763, attenuated caspase-3 activation and PARP cleavage induced by arsenite treatment indicating that GSK3 contributed to arsenite-induced apoptosis.	arsenite	114-122	poly(ADP-ribose) polymerase 1	Homo sapiens	89-93
17849503-5	2008	Two selective GSK3 inhibitors, lithium and SB216763, attenuated caspase-3 activation and PARP cleavage induced by arsenite treatment indicating that GSK3 contributed to arsenite-induced apoptosis.	arsenite	169-177	poly(ADP-ribose) polymerase 1	Homo sapiens	89-93
17849503-6	2008	Apoptotic signaling following exposure to arsenite involved cytochrome C release from mitochondria, and this was reduced by inhibition of GSK3 indicating that GSK3 promotes arsenite-induced apoptotic signaling upstream of mitochondrial disruption.	arsenite	42-50	cytochrome c, somatic	Homo sapiens	60-72
17849503-7	2008	Moreover, arsenite induced the translocation of Bax and p53 to the mitochondria and the activation-associated oligomerization of Bax, and these crucial events were reduced by inhibition of GSK3, indicating that GSK3 promotes arsenite-induced apoptosis by facilitating signals leading to mitochondrial apoptotic events.	arsenite	10-18	BCL2 associated X, apoptosis regulator	Homo sapiens	48-51
17849503-7	2008	Moreover, arsenite induced the translocation of Bax and p53 to the mitochondria and the activation-associated oligomerization of Bax, and these crucial events were reduced by inhibition of GSK3, indicating that GSK3 promotes arsenite-induced apoptosis by facilitating signals leading to mitochondrial apoptotic events.	arsenite	10-18	tumor protein p53	Homo sapiens	56-59
17849503-7	2008	Moreover, arsenite induced the translocation of Bax and p53 to the mitochondria and the activation-associated oligomerization of Bax, and these crucial events were reduced by inhibition of GSK3, indicating that GSK3 promotes arsenite-induced apoptosis by facilitating signals leading to mitochondrial apoptotic events.	arsenite	10-18	BCL2 associated X, apoptosis regulator	Homo sapiens	129-132
17849503-7	2008	Moreover, arsenite induced the translocation of Bax and p53 to the mitochondria and the activation-associated oligomerization of Bax, and these crucial events were reduced by inhibition of GSK3, indicating that GSK3 promotes arsenite-induced apoptosis by facilitating signals leading to mitochondrial apoptotic events.	arsenite	225-233	BCL2 associated X, apoptosis regulator	Homo sapiens	129-132
18435919-0	2008	The Arabidopsis thaliana aquaglyceroporin AtNIP7;1 is a pathway for arsenite uptake.	arsenite	68-76	NOD26-like intrinsic protein 7;1	Arabidopsis thaliana	42-50
18183357-4	2008	Hepatic reduced catalase (CAT) and glutathione peroxidase activities showed a depletion, whereas thiobarbituric acid reactive substances (TBARS) levels increased on arsenic exposure indicating arsenite-induced oxidative stress in blood and liver.	arsenite	193-201	catalase	Mus musculus	16-24
18252256-0	2008	Modulation of DNA polymerase beta-dependent base excision repair in cultured human cells after low dose exposure to arsenite.	arsenite	116-124	DNA polymerase beta	Homo sapiens	14-33
18504176-6	2008	The apoptotic ratio of p53(WT)-transfected cells induced by arsenite increased and that of p53(S15A)-transfected cells decreased significantly after arsenite stimulation, but no significant changes occurred in the apoptosis of p53(S46A)-transfected cells.	arsenite	60-68	tumor protein p53	Homo sapiens	23-26
18504176-6	2008	The apoptotic ratio of p53(WT)-transfected cells induced by arsenite increased and that of p53(S15A)-transfected cells decreased significantly after arsenite stimulation, but no significant changes occurred in the apoptosis of p53(S46A)-transfected cells.	arsenite	149-157	tumor protein p53	Homo sapiens	91-94
18504176-6	2008	The apoptotic ratio of p53(WT)-transfected cells induced by arsenite increased and that of p53(S15A)-transfected cells decreased significantly after arsenite stimulation, but no significant changes occurred in the apoptosis of p53(S46A)-transfected cells.	arsenite	149-157	tumor protein p53	Homo sapiens	91-94
18504176-7	2008	CONCLUSION: The phosphorylation on Ser15 of p53 plays an important role in mediating arsenite-induced cell apoptosis.	arsenite	85-93	tumor protein p53	Homo sapiens	44-47
18242949-5	2008	P35-RNA expression levels were significantly (p<0.01) increased by arsenite metabolites, while p35 protein was cleaved to p25 (and p10) after incubation with these metabolites.	arsenite	70-78	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	0-3
18334919-2	2008	It has recently been shown that arsenic(III)methyltransferase (AS3MT) enzyme catalyses the methylation of arsenite and monomethylarsonous acid (MMA).	arsenite	106-114	arsenite methyltransferase	Homo sapiens	63-68
18226606-3	2008	Incubation with arsenite concentration- and time-dependently increased the expression of stress proteins, heat shock protein 70, and heme oxygenase-1 in DRG explants.	arsenite	16-24	heme oxygenase 1	Homo sapiens	133-149
18226606-6	2008	At the same time, increases in the activating transcription factor-4 and C/EBP homologous protein and reduction in procaspase 12 levels indicated activation of the endoplasmic reticulum (ER) pathway in the arsenite-induced cytotoxicity in DRG explants.	arsenite	206-214	activating transcription factor 4	Homo sapiens	35-68
18226606-6	2008	At the same time, increases in the activating transcription factor-4 and C/EBP homologous protein and reduction in procaspase 12 levels indicated activation of the endoplasmic reticulum (ER) pathway in the arsenite-induced cytotoxicity in DRG explants.	arsenite	206-214	CCAAT enhancer binding protein alpha	Homo sapiens	73-78
18226606-14	2008	Glial-cell-derived neurotrophic factor appears to be protective against arsenite-induced peripheral neuropathy.	arsenite	72-80	glial cell derived neurotrophic factor	Homo sapiens	0-38
18404528-0	2008	Differential roles for Nrf2 and AP-1 in upregulation of HO-1 expression by arsenite in murine embryonic fibroblasts.	arsenite	75-83	nuclear factor, erythroid derived 2, like 2	Mus musculus	23-27
18404528-0	2008	Differential roles for Nrf2 and AP-1 in upregulation of HO-1 expression by arsenite in murine embryonic fibroblasts.	arsenite	75-83	jun proto-oncogene	Mus musculus	32-36
18404528-0	2008	Differential roles for Nrf2 and AP-1 in upregulation of HO-1 expression by arsenite in murine embryonic fibroblasts.	arsenite	75-83	heme oxygenase 1	Mus musculus	56-60
18404528-1	2008	Heme oxygenase-1 (HO-1) is markedly upregulated by sodium arsenite and previous studies implicated the transcriptional enhancers Nrf2 and AP-1 in arsenite-induced ho-1 gene expression in murine cells.	arsenite	58-66	heme oxygenase 1	Mus musculus	0-16
18404528-1	2008	Heme oxygenase-1 (HO-1) is markedly upregulated by sodium arsenite and previous studies implicated the transcriptional enhancers Nrf2 and AP-1 in arsenite-induced ho-1 gene expression in murine cells.	arsenite	58-66	heme oxygenase 1	Mus musculus	18-22
18404528-1	2008	Heme oxygenase-1 (HO-1) is markedly upregulated by sodium arsenite and previous studies implicated the transcriptional enhancers Nrf2 and AP-1 in arsenite-induced ho-1 gene expression in murine cells.	arsenite	58-66	nuclear factor, erythroid derived 2, like 2	Mus musculus	129-133
18404528-1	2008	Heme oxygenase-1 (HO-1) is markedly upregulated by sodium arsenite and previous studies implicated the transcriptional enhancers Nrf2 and AP-1 in arsenite-induced ho-1 gene expression in murine cells.	arsenite	58-66	heme oxygenase 1	Mus musculus	163-167
18404528-2	2008	To further evaluate the role of Nrf2 and its signalling pathway in the induction of HO-1 in response to low levels of arsenite, this paper studied wild-type and Nrf2-deficient murine embryonic fibroblasts.	arsenite	118-126	nuclear factor, erythroid derived 2, like 2	Mus musculus	32-36
18404528-2	2008	To further evaluate the role of Nrf2 and its signalling pathway in the induction of HO-1 in response to low levels of arsenite, this paper studied wild-type and Nrf2-deficient murine embryonic fibroblasts.	arsenite	118-126	heme oxygenase 1	Mus musculus	84-88
18404528-4	2008	The tyrosine kinase inhibitor genistein and JNK inhibitor SP600125 significantly attenuated arsenite induced increases in ho-1 mRNA levels in Nrf2 deficient cells but had negligible effects on Nrf2 activation, suggesting tyrosine kinase/JNK/c-Jun plays a key role in the HO-1 upregulation via AP-1.	arsenite	92-100	mitogen-activated protein kinase 8	Mus musculus	44-47
18404528-4	2008	The tyrosine kinase inhibitor genistein and JNK inhibitor SP600125 significantly attenuated arsenite induced increases in ho-1 mRNA levels in Nrf2 deficient cells but had negligible effects on Nrf2 activation, suggesting tyrosine kinase/JNK/c-Jun plays a key role in the HO-1 upregulation via AP-1.	arsenite	92-100	heme oxygenase 1	Mus musculus	122-126
18404528-4	2008	The tyrosine kinase inhibitor genistein and JNK inhibitor SP600125 significantly attenuated arsenite induced increases in ho-1 mRNA levels in Nrf2 deficient cells but had negligible effects on Nrf2 activation, suggesting tyrosine kinase/JNK/c-Jun plays a key role in the HO-1 upregulation via AP-1.	arsenite	92-100	nuclear factor, erythroid derived 2, like 2	Mus musculus	142-146
18404528-4	2008	The tyrosine kinase inhibitor genistein and JNK inhibitor SP600125 significantly attenuated arsenite induced increases in ho-1 mRNA levels in Nrf2 deficient cells but had negligible effects on Nrf2 activation, suggesting tyrosine kinase/JNK/c-Jun plays a key role in the HO-1 upregulation via AP-1.	arsenite	92-100	mitogen-activated protein kinase 8	Mus musculus	237-240
18404528-4	2008	The tyrosine kinase inhibitor genistein and JNK inhibitor SP600125 significantly attenuated arsenite induced increases in ho-1 mRNA levels in Nrf2 deficient cells but had negligible effects on Nrf2 activation, suggesting tyrosine kinase/JNK/c-Jun plays a key role in the HO-1 upregulation via AP-1.	arsenite	92-100	jun proto-oncogene	Mus musculus	241-246
18404528-4	2008	The tyrosine kinase inhibitor genistein and JNK inhibitor SP600125 significantly attenuated arsenite induced increases in ho-1 mRNA levels in Nrf2 deficient cells but had negligible effects on Nrf2 activation, suggesting tyrosine kinase/JNK/c-Jun plays a key role in the HO-1 upregulation via AP-1.	arsenite	92-100	heme oxygenase 1	Mus musculus	271-275
18404528-4	2008	The tyrosine kinase inhibitor genistein and JNK inhibitor SP600125 significantly attenuated arsenite induced increases in ho-1 mRNA levels in Nrf2 deficient cells but had negligible effects on Nrf2 activation, suggesting tyrosine kinase/JNK/c-Jun plays a key role in the HO-1 upregulation via AP-1.	arsenite	92-100	jun proto-oncogene	Mus musculus	293-297
18201741-2	2008	The goal of the present study was to determine the role of JNK pathway signaling for regulating B-cell apoptosis in two important but contrasting situations--global proteotoxic damage, induced by arsenite and hyperthermia, versus specific microtubule inhibition, induced by the anti-cancer drug vincristine, using the EW36 B-cell line.	arsenite	196-204	mitogen-activated protein kinase 8	Homo sapiens	59-62
18201741-4	2008	Exposure of EW36 B-cells to arsenite or lethal hyperthermia resulted in activation of the JNK pathway and induction of apoptosis.	arsenite	28-36	mitogen-activated protein kinase 8	Homo sapiens	90-93
18201741-9	2008	Furthermore, arsenite and hyperthermia treatments activated a p53/p21 pathway associated with apoptosis induction, whereas vincristine did not activate this pathway.	arsenite	13-21	tumor protein p53	Homo sapiens	62-65
18201741-9	2008	Furthermore, arsenite and hyperthermia treatments activated a p53/p21 pathway associated with apoptosis induction, whereas vincristine did not activate this pathway.	arsenite	13-21	H3 histone pseudogene 16	Homo sapiens	66-69
18247522-4	2008	Here, we identified the major arsenic-binding protein (As-BP) in the plasma of rats after oral administration of arsenite by the use of two different HPLC columns, gel filtration and anion exchange ones, coupled with an inductively coupled argon plasma mass spectrometer (ICP MS).	arsenite	113-121	par-3 family cell polarity regulator	Rattus norvegicus	55-60
18195013-4	2008	We show that the expression of the basic zipper transcriptional regulator ATF5 is induced in response to many different stresses, including endoplasmic reticulum stress, arsenite exposure, and proteasome inhibition, by a mechanism requiring eIF2 phosphorylation.	arsenite	170-178	activating transcription factor 5	Mus musculus	74-78
18195013-4	2008	We show that the expression of the basic zipper transcriptional regulator ATF5 is induced in response to many different stresses, including endoplasmic reticulum stress, arsenite exposure, and proteasome inhibition, by a mechanism requiring eIF2 phosphorylation.	arsenite	170-178	eukaryotic translation initiation factor 2, subunit 2 (beta)	Mus musculus	241-245
18222423-6	2008	Hence, an initial increase in DR5 surface expression (either by gamma-irradiation or arsenite), and subsequent downregulation of antiapoptotic cFLIP and Bcl-xL (by resveratrol), appear to constitute an efficient approach to reactivate apoptotic death pathways in TRAIL-resistant human melanomas.	arsenite	85-93	TNF receptor superfamily member 10b	Homo sapiens	30-33
18247522-4	2008	Here, we identified the major arsenic-binding protein (As-BP) in the plasma of rats after oral administration of arsenite by the use of two different HPLC columns, gel filtration and anion exchange ones, coupled with an inductively coupled argon plasma mass spectrometer (ICP MS).	arsenite	113-121	par-3 family cell polarity regulator	Rattus norvegicus	30-53
18296743-4	2008	Serum aspartate aminotransferase (AST), indicative of liver injury, was elevated in both arsenite and arsenate groups, and a high fat diet further increased these levels.	arsenite	89-97	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	6-32
18220366-5	2008	Previously, we demonstrated that methylated As (III) compounds are more efficient than arsenite in releasing zinc from ZnXPAzf, the zinc finger of XPA, a crucial member of the NER complex [Schwerdtle, T., Walter, I., and Hartwig, A.	arsenite	87-95	XPA, DNA damage recognition and repair factor	Homo sapiens	121-124
18296743-4	2008	Serum aspartate aminotransferase (AST), indicative of liver injury, was elevated in both arsenite and arsenate groups, and a high fat diet further increased these levels.	arsenite	89-97	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	34-37
18164070-4	2008	According to our experimental data some of the protein targets to which arsenite may bind in vivo include tubulin, poly(ADP-ribose)polymerase (PARP-1), thioredoxin reductase, estrogen receptor-alpha, arsenic(+3)methyltransferase and Keap-1.	arsenite	72-80	poly [ADP-ribose] polymerase 1	Bos taurus	143-149
18336662-3	2008	Using knock-out and transgenic animal approach, as well as standard, methods of heat shock protein 70 (HSP70) induction (i.e. thermal stress and arsenite administration), it has been shown that HSP70 protects against cell injury and acinar necrosis in experimental model of pancreatitis in animals.	arsenite	145-153	heat shock protein family A (Hsp70) member 4	Homo sapiens	80-101
18336662-3	2008	Using knock-out and transgenic animal approach, as well as standard, methods of heat shock protein 70 (HSP70) induction (i.e. thermal stress and arsenite administration), it has been shown that HSP70 protects against cell injury and acinar necrosis in experimental model of pancreatitis in animals.	arsenite	145-153	heat shock protein family A (Hsp70) member 4	Homo sapiens	103-108
18336662-3	2008	Using knock-out and transgenic animal approach, as well as standard, methods of heat shock protein 70 (HSP70) induction (i.e. thermal stress and arsenite administration), it has been shown that HSP70 protects against cell injury and acinar necrosis in experimental model of pancreatitis in animals.	arsenite	145-153	heat shock protein family A (Hsp70) member 4	Homo sapiens	194-199
18164070-4	2008	According to our experimental data some of the protein targets to which arsenite may bind in vivo include tubulin, poly(ADP-ribose)polymerase (PARP-1), thioredoxin reductase, estrogen receptor-alpha, arsenic(+3)methyltransferase and Keap-1.	arsenite	72-80	estrogen receptor 1	Bos taurus	175-198
18164070-4	2008	According to our experimental data some of the protein targets to which arsenite may bind in vivo include tubulin, poly(ADP-ribose)polymerase (PARP-1), thioredoxin reductase, estrogen receptor-alpha, arsenic(+3)methyltransferase and Keap-1.	arsenite	72-80	kelch like ECH associated protein 1	Bos taurus	233-239
18164070-6	2008	Among many other possible arsenite binding sites are rat hemoglobin, the DNA repair enzyme xeroderma pigmentosum protein A (XPA), and other C2H2, C3H and C4 zinc finger proteins including members of the steroid receptor superfamily (e.g. glucocorticoid receptor).	arsenite	26-34	XPA, DNA damage recognition and repair factor	Rattus norvegicus	124-127
19209639-3	2008	It was found that As(V) was completely reduced to As(III) (i.e., arsenite) in 21 h. After 3-d incubation, a yellow solid was precipitated and the concentration of As(III) decreased sharply.	arsenite	65-73	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	18-23
18086880-2	2008	ARS2 is an evolutionarily conserved gene that confers arsenite resistance on arsenite-sensitive Chinese hamster ovary cells.	arsenite	54-62	serrate RNA effector molecule homolog	Cricetulus griseus	0-4
18086880-2	2008	ARS2 is an evolutionarily conserved gene that confers arsenite resistance on arsenite-sensitive Chinese hamster ovary cells.	arsenite	77-85	serrate RNA effector molecule homolog	Cricetulus griseus	0-4
18197291-0	2008	PI-3K/Akt pathway-dependent cyclin D1 expression is responsible for arsenite-induced human keratinocyte transformation.	arsenite	68-76	AKT serine/threonine kinase 1	Homo sapiens	6-9
18197291-0	2008	PI-3K/Akt pathway-dependent cyclin D1 expression is responsible for arsenite-induced human keratinocyte transformation.	arsenite	68-76	cyclin D1	Homo sapiens	28-37
18197291-3	2008	OBJECTIVES: In this study, we investigated the potential role of PI-3K/Akt/cyclin D1in the transformation of human keratinocytic cells upon arsenite exposure.	arsenite	140-148	AKT serine/threonine kinase 1	Homo sapiens	71-74
18197291-3	2008	OBJECTIVES: In this study, we investigated the potential role of PI-3K/Akt/cyclin D1in the transformation of human keratinocytic cells upon arsenite exposure.	arsenite	140-148	cyclin D1	Homo sapiens	75-84
18197291-8	2008	Treatment of cells with arsenite also induced significant activation of PI-3K and Akt, which was responsible for the anchorage-independent cell growth induced by arsenite exposure.	arsenite	24-32	AKT serine/threonine kinase 1	Homo sapiens	82-85
18197291-8	2008	Treatment of cells with arsenite also induced significant activation of PI-3K and Akt, which was responsible for the anchorage-independent cell growth induced by arsenite exposure.	arsenite	162-170	AKT serine/threonine kinase 1	Homo sapiens	82-85
18197291-9	2008	Furthermore, our data also indicated that cyclin D1 is an important downstream molecule involved in PI-3K/Akt-mediated cell transformation upon arsenite exposure based on the facts that inhibition of cyclin D1 expression by dominant negative mutants of PI-3K, and Akt, or the knockdown of the cyclin D1 expression by its specific siRNA in the HaCat cells resulted in impairing of anchorage-independent growth of HaCat cells induced by arsenite.	arsenite	144-152	cyclin D1	Homo sapiens	42-51
18197291-9	2008	Furthermore, our data also indicated that cyclin D1 is an important downstream molecule involved in PI-3K/Akt-mediated cell transformation upon arsenite exposure based on the facts that inhibition of cyclin D1 expression by dominant negative mutants of PI-3K, and Akt, or the knockdown of the cyclin D1 expression by its specific siRNA in the HaCat cells resulted in impairing of anchorage-independent growth of HaCat cells induced by arsenite.	arsenite	144-152	AKT serine/threonine kinase 1	Homo sapiens	106-109
18197291-9	2008	Furthermore, our data also indicated that cyclin D1 is an important downstream molecule involved in PI-3K/Akt-mediated cell transformation upon arsenite exposure based on the facts that inhibition of cyclin D1 expression by dominant negative mutants of PI-3K, and Akt, or the knockdown of the cyclin D1 expression by its specific siRNA in the HaCat cells resulted in impairing of anchorage-independent growth of HaCat cells induced by arsenite.	arsenite	144-152	cyclin D1	Homo sapiens	200-209
18197291-9	2008	Furthermore, our data also indicated that cyclin D1 is an important downstream molecule involved in PI-3K/Akt-mediated cell transformation upon arsenite exposure based on the facts that inhibition of cyclin D1 expression by dominant negative mutants of PI-3K, and Akt, or the knockdown of the cyclin D1 expression by its specific siRNA in the HaCat cells resulted in impairing of anchorage-independent growth of HaCat cells induced by arsenite.	arsenite	144-152	AKT serine/threonine kinase 1	Homo sapiens	264-267
18197291-9	2008	Furthermore, our data also indicated that cyclin D1 is an important downstream molecule involved in PI-3K/Akt-mediated cell transformation upon arsenite exposure based on the facts that inhibition of cyclin D1 expression by dominant negative mutants of PI-3K, and Akt, or the knockdown of the cyclin D1 expression by its specific siRNA in the HaCat cells resulted in impairing of anchorage-independent growth of HaCat cells induced by arsenite.	arsenite	144-152	cyclin D1	Homo sapiens	200-209
18197291-9	2008	Furthermore, our data also indicated that cyclin D1 is an important downstream molecule involved in PI-3K/Akt-mediated cell transformation upon arsenite exposure based on the facts that inhibition of cyclin D1 expression by dominant negative mutants of PI-3K, and Akt, or the knockdown of the cyclin D1 expression by its specific siRNA in the HaCat cells resulted in impairing of anchorage-independent growth of HaCat cells induced by arsenite.	arsenite	435-443	cyclin D1	Homo sapiens	42-51
18197291-9	2008	Furthermore, our data also indicated that cyclin D1 is an important downstream molecule involved in PI-3K/Akt-mediated cell transformation upon arsenite exposure based on the facts that inhibition of cyclin D1 expression by dominant negative mutants of PI-3K, and Akt, or the knockdown of the cyclin D1 expression by its specific siRNA in the HaCat cells resulted in impairing of anchorage-independent growth of HaCat cells induced by arsenite.	arsenite	435-443	AKT serine/threonine kinase 1	Homo sapiens	106-109
18197291-10	2008	CONCLUSION: Our results demonstrate that PI-3K/Akt-mediated cyclin D1 expression is at least one key event implicated in the arsenite human skin carcinogenic effect.	arsenite	125-133	AKT serine/threonine kinase 1	Homo sapiens	47-50
18197291-10	2008	CONCLUSION: Our results demonstrate that PI-3K/Akt-mediated cyclin D1 expression is at least one key event implicated in the arsenite human skin carcinogenic effect.	arsenite	125-133	cyclin D1	Homo sapiens	60-69
18551895-0	2008	Tissue levels of arsenicals and skin tumor response following administration of monomethylarsonous acid and arsenite to K6/ODC mice.	arsenite	108-116	keratin 6	Mus musculus	120-126
18551895-4	2008	In K6/ODC transgenic mice that consumed a normal diet (Purina 5002), a 26-week drinking water exposure to 10 ppm arsenite resulted in 5% of the treated animals having squamous skin tumors.	arsenite	113-121	ornithine decarboxylase, structural 1	Mus musculus	6-9
18551895-9	2008	In summary, studies with MMA(III) and arsenite-treated K6/ODC transgenic mice showed (1) a low-methionine diet substantially altered mouse tissue arsenical levels and (2) numerically elevated incidence of mouse skin tumors following arsenical exposures.	arsenite	38-46	ornithine decarboxylase, structural 1	Mus musculus	58-61
18418899-0	2008	Selective activation of NF-kappaB and E2F by low concentration of arsenite in U937 human monocytic leukemia cells.	arsenite	66-74	nuclear factor kappa B subunit 1	Homo sapiens	24-33
18418899-6	2008	In contrast, activation of NF-kappaB took place only at 1 microM arsenite, whereas 10 microM arsenite showed no recognizable effect on this nuclear transcription factor in the protein/DNA array analysis.	arsenite	65-73	nuclear factor kappa B subunit 1	Homo sapiens	27-36
18418899-7	2008	EMSA using a NF-kappaB consensus probe indicates the functional activation of RelB/p50 in the presence of 1 microM arsenite, confirming the above results.	arsenite	115-123	nuclear factor kappa B subunit 1	Homo sapiens	13-22
18418899-7	2008	EMSA using a NF-kappaB consensus probe indicates the functional activation of RelB/p50 in the presence of 1 microM arsenite, confirming the above results.	arsenite	115-123	nuclear factor kappa B subunit 1	Homo sapiens	83-86
18418899-8	2008	Luciferase reporter assay for NF-kappaB showed activation of NF-kappaB in the presence of 1 microM arsenite.	arsenite	99-107	nuclear factor kappa B subunit 1	Homo sapiens	30-39
18418899-8	2008	Luciferase reporter assay for NF-kappaB showed activation of NF-kappaB in the presence of 1 microM arsenite.	arsenite	99-107	nuclear factor kappa B subunit 1	Homo sapiens	61-70
18418899-9	2008	Interleukin (IL)-8 and B-cell-activating factor of the tumor necrosis factor family (BAFF) mRNA expression, which have been shown to be regulated through NF-kappaB, were activated in the presence of 1 microM arsenite.	arsenite	208-216	TNF superfamily member 13b	Homo sapiens	85-89
18418899-9	2008	Interleukin (IL)-8 and B-cell-activating factor of the tumor necrosis factor family (BAFF) mRNA expression, which have been shown to be regulated through NF-kappaB, were activated in the presence of 1 microM arsenite.	arsenite	208-216	nuclear factor kappa B subunit 1	Homo sapiens	154-163
18418899-10	2008	These results support the hypothesis that the primary action of nonapoptotic concentrations of arsenite in this cell line is activation of NF-kappaB, signaling as a decision maker for end results such as inflammation disease or cancer.	arsenite	95-103	nuclear factor kappa B subunit 1	Homo sapiens	139-148
17901115-10	2008	Specific silencing of the GSTO-1 by RNAi created worms with an increased sensitivity to several prooxidants, arsenite, and heat shock.	arsenite	109-117	Glutathione transferase omega-1	Caenorhabditis elegans	26-32
17976673-5	2008	Among these, gamma-glutamyltranspeptidase 1 (GGT1) and NF kappa B inhibitor-epsilon (NFKBIE) showed higher expression levels in arsenite-resistant cells.	arsenite	128-136	gamma-glutamyltransferase 1	Homo sapiens	13-43
17976673-5	2008	Among these, gamma-glutamyltranspeptidase 1 (GGT1) and NF kappa B inhibitor-epsilon (NFKBIE) showed higher expression levels in arsenite-resistant cells.	arsenite	128-136	gamma-glutamyltransferase 1	Homo sapiens	45-49
17976673-5	2008	Among these, gamma-glutamyltranspeptidase 1 (GGT1) and NF kappa B inhibitor-epsilon (NFKBIE) showed higher expression levels in arsenite-resistant cells.	arsenite	128-136	NFKB inhibitor epsilon	Homo sapiens	55-83
17976673-5	2008	Among these, gamma-glutamyltranspeptidase 1 (GGT1) and NF kappa B inhibitor-epsilon (NFKBIE) showed higher expression levels in arsenite-resistant cells.	arsenite	128-136	NFKB inhibitor epsilon	Homo sapiens	85-91
17976673-7	2008	Reduction of GGT1 expression level in arsenite-resistant lymphoblasts with GGT1-specific siRNA resulted in increased cell sensitivity to arsenite.	arsenite	38-46	gamma-glutamyltransferase 1	Homo sapiens	13-17
17976673-7	2008	Reduction of GGT1 expression level in arsenite-resistant lymphoblasts with GGT1-specific siRNA resulted in increased cell sensitivity to arsenite.	arsenite	38-46	gamma-glutamyltransferase 1	Homo sapiens	75-79
17976673-7	2008	Reduction of GGT1 expression level in arsenite-resistant lymphoblasts with GGT1-specific siRNA resulted in increased cell sensitivity to arsenite.	arsenite	137-145	gamma-glutamyltransferase 1	Homo sapiens	13-17
17976673-7	2008	Reduction of GGT1 expression level in arsenite-resistant lymphoblasts with GGT1-specific siRNA resulted in increased cell sensitivity to arsenite.	arsenite	137-145	gamma-glutamyltransferase 1	Homo sapiens	75-79
17976673-8	2008	In conclusion, we have demonstrated for the first time that expression levels of GGT1 and possibly NFKBIE might be useful as biomarkers of genetic susceptibility to arsenite.	arsenite	165-173	gamma-glutamyltransferase 1	Homo sapiens	81-85
17976673-8	2008	In conclusion, we have demonstrated for the first time that expression levels of GGT1 and possibly NFKBIE might be useful as biomarkers of genetic susceptibility to arsenite.	arsenite	165-173	NFKB inhibitor epsilon	Homo sapiens	99-105
20467584-3	2008	We have recently shown that arsenite and its methylated metabolites inhibit insulin-stimulated glucose uptake in cultured adipocytes by disrupting insulin-activated signal transduction pathway and preventing insulin-dependent translocation of GLUT4 transporters to the plasma membrane.	arsenite	28-36	insulin	Homo sapiens	76-83
20467584-3	2008	We have recently shown that arsenite and its methylated metabolites inhibit insulin-stimulated glucose uptake in cultured adipocytes by disrupting insulin-activated signal transduction pathway and preventing insulin-dependent translocation of GLUT4 transporters to the plasma membrane.	arsenite	28-36	insulin	Homo sapiens	147-154
20467584-3	2008	We have recently shown that arsenite and its methylated metabolites inhibit insulin-stimulated glucose uptake in cultured adipocytes by disrupting insulin-activated signal transduction pathway and preventing insulin-dependent translocation of GLUT4 transporters to the plasma membrane.	arsenite	28-36	insulin	Homo sapiens	147-154
20467584-3	2008	We have recently shown that arsenite and its methylated metabolites inhibit insulin-stimulated glucose uptake in cultured adipocytes by disrupting insulin-activated signal transduction pathway and preventing insulin-dependent translocation of GLUT4 transporters to the plasma membrane.	arsenite	28-36	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	243-248
18077580-5	2007	Furthermore, NAC inhibited arsenite-induced elevation in the expression of stress proteins, such as heat shock protein 70 and heme oxygenase 1, as well as arsenite-induced phosphorylation of p38 mitogen-activated protein kinase.	arsenite	27-35	heme oxygenase 1	Homo sapiens	126-142
20020861-6	2008	Induction of the HMOX1 was detected with a dose of arsenite at as low as 0.3 muM (0.04 ppm) and reached its maximum at 4 h after the treatment.	arsenite	51-59	heme oxygenase 1	Homo sapiens	17-22
20020861-7	2008	The arsenite-induced HMOX1 expression was attenuated by the promoted glutathione (GSH) synthesis by N-acetyl-L-cysteine (NAC).	arsenite	4-12	heme oxygenase 1	Homo sapiens	21-26
20020861-7	2008	The arsenite-induced HMOX1 expression was attenuated by the promoted glutathione (GSH) synthesis by N-acetyl-L-cysteine (NAC).	arsenite	4-12	X-linked Kx blood group	Homo sapiens	121-124
20020861-9	2008	Thus, induction of HMOX1 gene is highly sensitive and also selective against arsenite in the cells.	arsenite	77-85	heme oxygenase 1	Homo sapiens	19-24
17889916-2	2007	Human arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite.	arsenite	101-109	arsenite methyltransferase	Homo sapiens	6-52
17889916-2	2007	Human arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite.	arsenite	101-109	arsenite methyltransferase	Homo sapiens	54-59
18070357-9	2007	beta-actin glutathionylation by GSH was inhibited by arsenite and dimedone suggesting that the mechanism involved formation of a cysteinyl sulfenic acid residue in beta-actin.	arsenite	53-61	POTE ankyrin domain family member F	Homo sapiens	0-10
18070357-9	2007	beta-actin glutathionylation by GSH was inhibited by arsenite and dimedone suggesting that the mechanism involved formation of a cysteinyl sulfenic acid residue in beta-actin.	arsenite	53-61	POTE ankyrin domain family member F	Homo sapiens	164-174
18077580-7	2007	In the mitochondrial pathway, NAC attenuated arsenite-induced elevation in Bcl-2 level and cytosolic cytochrome c, as well as arsenite-induced reduction in procaspase-3 levels.	arsenite	45-53	BCL2 apoptosis regulator	Homo sapiens	75-80
18077580-7	2007	In the mitochondrial pathway, NAC attenuated arsenite-induced elevation in Bcl-2 level and cytosolic cytochrome c, as well as arsenite-induced reduction in procaspase-3 levels.	arsenite	45-53	cytochrome c, somatic	Homo sapiens	101-113
18077580-7	2007	In the mitochondrial pathway, NAC attenuated arsenite-induced elevation in Bcl-2 level and cytosolic cytochrome c, as well as arsenite-induced reduction in procaspase-3 levels.	arsenite	126-134	caspase 3	Homo sapiens	156-168
18077580-8	2007	In the ER pathway, NAC suppressed arsenite-induced increases in activating transcription factor 6 and C/EBP homologous protein in the nuclear fraction.	arsenite	34-42	transcription factor A, mitochondrial	Homo sapiens	75-97
18077580-8	2007	In the ER pathway, NAC suppressed arsenite-induced increases in activating transcription factor 6 and C/EBP homologous protein in the nuclear fraction.	arsenite	34-42	CCAAT enhancer binding protein alpha	Homo sapiens	102-107
18077580-9	2007	Furthermore, arsenite-induced reductions in procaspase-12 and elevation in BIP and caspase-12, an ER-specific enzyme, were prevented after NAC incubation.	arsenite	13-21	heat shock protein family A (Hsp70) member 5	Homo sapiens	75-78
17945324-7	2007	TUNEL analysis confirmed that there was indeed a significantly reduced arsenite-induced apoptosis found in p53-compromised cells.	arsenite	71-79	tumor protein p53	Homo sapiens	107-110
17765279-0	2007	Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity.	arsenite	50-58	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
17915961-3	2007	While arsenite alone did not induce procoagulant activity, it significantly enhanced thrombin-induced procoagulant activity of human platelets in a concentration- and time-dependent manner.	arsenite	6-14	coagulation factor II, thrombin	Homo sapiens	85-93
17938202-0	2007	ATF4-dependent oxidative induction of the DNA repair enzyme Ape1 counteracts arsenite cytotoxicity and suppresses arsenite-mediated mutagenesis.	arsenite	77-85	activating transcription factor 4	Homo sapiens	0-4
17938202-0	2007	ATF4-dependent oxidative induction of the DNA repair enzyme Ape1 counteracts arsenite cytotoxicity and suppresses arsenite-mediated mutagenesis.	arsenite	77-85	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	60-64
17938202-0	2007	ATF4-dependent oxidative induction of the DNA repair enzyme Ape1 counteracts arsenite cytotoxicity and suppresses arsenite-mediated mutagenesis.	arsenite	114-122	activating transcription factor 4	Homo sapiens	0-4
17938202-0	2007	ATF4-dependent oxidative induction of the DNA repair enzyme Ape1 counteracts arsenite cytotoxicity and suppresses arsenite-mediated mutagenesis.	arsenite	114-122	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	60-64
17938202-3	2007	In mouse 10T(1/2) fibroblasts, Ape1 induction in response to arsenite occurred about equally at the mRNA, protein, and enzyme activity levels.	arsenite	61-69	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	31-35
17938202-4	2007	Analysis of the APE1 promoter region revealed an AP-1/CREB binding site essential for arsenite-induced transcriptional activation in both mouse and human cells.	arsenite	86-94	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	16-20
17938202-6	2007	RNA interference targeting c-Jun or ATF4 eliminated arsenite-induced APE1 transcription.	arsenite	52-60	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	27-32
17938202-6	2007	RNA interference targeting c-Jun or ATF4 eliminated arsenite-induced APE1 transcription.	arsenite	52-60	activating transcription factor 4	Homo sapiens	36-40
17938202-6	2007	RNA interference targeting c-Jun or ATF4 eliminated arsenite-induced APE1 transcription.	arsenite	52-60	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	69-73
17938202-7	2007	Suppression of Ape1 or ATF4 sensitized both mouse fibroblasts (10T(1/2)) and human lymphoblastoid cells (TK6) to arsenite cytotoxicity.	arsenite	113-121	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	15-19
17938202-7	2007	Suppression of Ape1 or ATF4 sensitized both mouse fibroblasts (10T(1/2)) and human lymphoblastoid cells (TK6) to arsenite cytotoxicity.	arsenite	113-121	activating transcription factor 4	Mus musculus	23-27
17938202-8	2007	Expression of Ape1 from a transgene did not efficiently restore arsenite resistance in ATF4-depleted cells but did offset initial accumulation of abasic DNA damage following arsenite treatment.	arsenite	174-182	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	14-18
17945324-9	2007	In our present study, reduced p21 and Gadd45a expressions and increased centrosomal abnormality (atopic and multiple centrosomes) were observed in both arsenite-treated H1355 and p53-inhibited BEAS-2B cells as compared with similarly treated BEAS-2B cells.	arsenite	152-160	H3 histone pseudogene 16	Homo sapiens	30-33
17938202-9	2007	Mutagenesis by arsenite (at the TK and HPRT loci in TK6 cells) was observed only for ATF4-depleted cells, which was strongly offset by Ape1 expression from a transgene.	arsenite	15-23	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	39-43
17945324-9	2007	In our present study, reduced p21 and Gadd45a expressions and increased centrosomal abnormality (atopic and multiple centrosomes) were observed in both arsenite-treated H1355 and p53-inhibited BEAS-2B cells as compared with similarly treated BEAS-2B cells.	arsenite	152-160	growth arrest and DNA damage inducible alpha	Homo sapiens	38-45
17938202-9	2007	Mutagenesis by arsenite (at the TK and HPRT loci in TK6 cells) was observed only for ATF4-depleted cells, which was strongly offset by Ape1 expression from a transgene.	arsenite	15-23	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	135-139
17945324-9	2007	In our present study, reduced p21 and Gadd45a expressions and increased centrosomal abnormality (atopic and multiple centrosomes) were observed in both arsenite-treated H1355 and p53-inhibited BEAS-2B cells as compared with similarly treated BEAS-2B cells.	arsenite	152-160	tumor protein p53	Homo sapiens	179-182
17938202-10	2007	Therefore, the ATF4-mediated up-regulation of Ape1 and other genes plays a key role against arsenite-mediated toxicity and mutagenesis.	arsenite	92-100	activating transcription factor 4	Homo sapiens	15-19
17699585-2	2007	We show that the same conditions (a 30-min, 42 degrees C heat shock or oxidative stress induced by arsenite) also reduce the endoplasmic reticulum (ER)-associated turnover of disease-causing mutants of Cx32 and the cystic fibrosis transmembrane conductance regulator (CFTR), as well as that of WT CFTR and unassembled Ig light chain.	arsenite	99-107	gap junction protein beta 1	Homo sapiens	202-206
17938202-10	2007	Therefore, the ATF4-mediated up-regulation of Ape1 and other genes plays a key role against arsenite-mediated toxicity and mutagenesis.	arsenite	92-100	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	46-50
17699585-2	2007	We show that the same conditions (a 30-min, 42 degrees C heat shock or oxidative stress induced by arsenite) also reduce the endoplasmic reticulum (ER)-associated turnover of disease-causing mutants of Cx32 and the cystic fibrosis transmembrane conductance regulator (CFTR), as well as that of WT CFTR and unassembled Ig light chain.	arsenite	99-107	CF transmembrane conductance regulator	Homo sapiens	215-266
17699585-2	2007	We show that the same conditions (a 30-min, 42 degrees C heat shock or oxidative stress induced by arsenite) also reduce the endoplasmic reticulum (ER)-associated turnover of disease-causing mutants of Cx32 and the cystic fibrosis transmembrane conductance regulator (CFTR), as well as that of WT CFTR and unassembled Ig light chain.	arsenite	99-107	CF transmembrane conductance regulator	Homo sapiens	268-272
17699585-2	2007	We show that the same conditions (a 30-min, 42 degrees C heat shock or oxidative stress induced by arsenite) also reduce the endoplasmic reticulum (ER)-associated turnover of disease-causing mutants of Cx32 and the cystic fibrosis transmembrane conductance regulator (CFTR), as well as that of WT CFTR and unassembled Ig light chain.	arsenite	99-107	CF transmembrane conductance regulator	Homo sapiens	297-301
17942904-10	2007	Furthermore, our study revealed that ABF1, a multifunctional transcriptional factor, regulates genes involved in both arsenite and arsenate sensitivity and resistance.	arsenite	118-126	DNA-binding protein ABF1	Saccharomyces cerevisiae S288C	37-41
17906315-8	2007	In addition, the expression of mutant p53 increased in parallel with comet scores, and the maximal expression of mutant p53 was observed at 4 microM arsenite.	arsenite	149-157	tumor protein p53	Homo sapiens	38-41
17906315-8	2007	In addition, the expression of mutant p53 increased in parallel with comet scores, and the maximal expression of mutant p53 was observed at 4 microM arsenite.	arsenite	149-157	tumor protein p53	Homo sapiens	120-123
17906315-11	2007	This study provides us with knowledge of the relationship between p53 and COX-2 over-expression in arsenite-treated urothelial cells and suggests a potential therapeutic role of COX-2 inhibitors in human urothelial malignancies.	arsenite	99-107	tumor protein p53	Homo sapiens	66-69
17906315-11	2007	This study provides us with knowledge of the relationship between p53 and COX-2 over-expression in arsenite-treated urothelial cells and suggests a potential therapeutic role of COX-2 inhibitors in human urothelial malignancies.	arsenite	99-107	prostaglandin-endoperoxide synthase 2	Homo sapiens	74-79
17906315-11	2007	This study provides us with knowledge of the relationship between p53 and COX-2 over-expression in arsenite-treated urothelial cells and suggests a potential therapeutic role of COX-2 inhibitors in human urothelial malignancies.	arsenite	99-107	prostaglandin-endoperoxide synthase 2	Homo sapiens	178-183
17874847-6	2007	Copper, a severe interfering species commonly found in groundwater, did not interfere, and the biosensor was applicable for repeated analysis of spiked arsenite in tap water, river water, and a commercial mineral water.	arsenite	152-160	nuclear RNA export factor 1	Homo sapiens	164-167
17942904-11	2007	However, REB1 and RAP1 transcriptional regulators were common to only arsenate- and arsenite-sensitive genes, respectively.	arsenite	84-92	DNA-binding protein REB1	Saccharomyces cerevisiae S288C	9-13
17942904-11	2007	However, REB1 and RAP1 transcriptional regulators were common to only arsenate- and arsenite-sensitive genes, respectively.	arsenite	84-92	DNA-binding transcription factor RAP1	Saccharomyces cerevisiae S288C	18-22
17681577-4	2007	Furthermore, local infusion of arsenite (5 nmol) decreased GSH content and increased expression of heat shock protein 70 and heme oxygenase-1 in the infused SN.	arsenite	31-39	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	99-120
17707572-6	2007	The sequencing of four arsenite-sensitive RAPD bands showed that the RB1CC1 and PACE4 genes might be the DNA targets of sodium arsenite treatment.	arsenite	23-31	RB1 inducible coiled-coil 1	Homo sapiens	69-75
17681577-4	2007	Furthermore, local infusion of arsenite (5 nmol) decreased GSH content and increased expression of heat shock protein 70 and heme oxygenase-1 in the infused SN.	arsenite	31-39	heme oxygenase 1	Rattus norvegicus	125-141
17681577-5	2007	Aggregation of alpha-synuclein, a putative pathological protein involved in several CNS neurodegenerative diseases, was elevated in the arsenite-infused SN.	arsenite	136-144	synuclein alpha	Rattus norvegicus	15-30
17681577-9	2007	For mitochondrial activation, cytosolic cytochrome c and caspase-3 levels were elevated in the arsenite-infused SN.	arsenite	95-103	caspase 3	Rattus norvegicus	57-66
17681577-10	2007	In ER pathway, arsenite increased activating transcription factor-4, X-box binding protein 1, C/EBP homologues protein (CHOP) and cytosolic immunoglobulin binding protein levels.	arsenite	15-23	activating transcription factor 4	Rattus norvegicus	34-67
17681577-10	2007	In ER pathway, arsenite increased activating transcription factor-4, X-box binding protein 1, C/EBP homologues protein (CHOP) and cytosolic immunoglobulin binding protein levels.	arsenite	15-23	X-box binding protein 1	Rattus norvegicus	69-92
17681577-10	2007	In ER pathway, arsenite increased activating transcription factor-4, X-box binding protein 1, C/EBP homologues protein (CHOP) and cytosolic immunoglobulin binding protein levels.	arsenite	15-23	CCAAT/enhancer binding protein gamma	Rattus norvegicus	94-99
17681577-10	2007	In ER pathway, arsenite increased activating transcription factor-4, X-box binding protein 1, C/EBP homologues protein (CHOP) and cytosolic immunoglobulin binding protein levels.	arsenite	15-23	DNA-damage inducible transcript 3	Rattus norvegicus	120-124
17707572-6	2007	The sequencing of four arsenite-sensitive RAPD bands showed that the RB1CC1 and PACE4 genes might be the DNA targets of sodium arsenite treatment.	arsenite	23-31	proprotein convertase subtilisin/kexin type 6	Homo sapiens	80-85
17645694-0	2007	Melatonin attenuates arsenite-induced apoptosis in rat brain: involvement of mitochondrial and endoplasmic reticulum pathways and aggregation of alpha-synuclein.	arsenite	21-29	synuclein alpha	Rattus norvegicus	145-160
17340120-0	2007	Arsenite induced oxidative damage in mouse liver is associated with increased cytokeratin 18 expression.	arsenite	0-8	keratin 18	Mus musculus	78-92
17340120-12	2007	Results suggest that CK18 expression may be a sensible early biomarker of oxidative stress and damage induced by arsenite in vitro and in vivo.	arsenite	113-121	keratin 18	Mus musculus	21-25
17645694-4	2007	Furthermore, melatonin attenuated arsenite-induced increases in heat shock protein 70 and heme oxygenase-1 as well as phosphorylation of p38 mitogen-activated protein kinase and elevations in cyclooxygenase II and inducible nitric oxide synthase expression.	arsenite	34-42	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	64-85
17645694-4	2007	Furthermore, melatonin attenuated arsenite-induced increases in heat shock protein 70 and heme oxygenase-1 as well as phosphorylation of p38 mitogen-activated protein kinase and elevations in cyclooxygenase II and inducible nitric oxide synthase expression.	arsenite	34-42	heme oxygenase 1	Rattus norvegicus	90-106
17645694-7	2007	In the mitochondrial pathway, systemic melatonin inhibited arsenite-induced elevations in Bcl-2 and cytosolic cytochrome c as well as arsenite-induced reductions in procaspase-3 levels and elevations in active caspase-3 levels in the infused SN.	arsenite	59-67	BCL2, apoptosis regulator	Rattus norvegicus	90-95
17645694-7	2007	In the mitochondrial pathway, systemic melatonin inhibited arsenite-induced elevations in Bcl-2 and cytosolic cytochrome c as well as arsenite-induced reductions in procaspase-3 levels and elevations in active caspase-3 levels in the infused SN.	arsenite	134-142	caspase 3	Rattus norvegicus	168-177
17645694-8	2007	Regarding the ER pathway, melatonin attenuated arsenite-induced elevations in activating transcription factor-4, CCAAT/enhancer binding protein (C/EBP) homologues protein, X-bon binding protein (XBP-1) and cytosolic immunoglobulin binding protein (BIP) as well as reductions in procaspase 12 levels.	arsenite	47-55	activating transcription factor 4	Rattus norvegicus	78-111
17645694-8	2007	Regarding the ER pathway, melatonin attenuated arsenite-induced elevations in activating transcription factor-4, CCAAT/enhancer binding protein (C/EBP) homologues protein, X-bon binding protein (XBP-1) and cytosolic immunoglobulin binding protein (BIP) as well as reductions in procaspase 12 levels.	arsenite	47-55	CCAAT/enhancer binding protein gamma	Rattus norvegicus	113-143
17645694-8	2007	Regarding the ER pathway, melatonin attenuated arsenite-induced elevations in activating transcription factor-4, CCAAT/enhancer binding protein (C/EBP) homologues protein, X-bon binding protein (XBP-1) and cytosolic immunoglobulin binding protein (BIP) as well as reductions in procaspase 12 levels.	arsenite	47-55	CCAAT/enhancer binding protein gamma	Rattus norvegicus	145-150
17645694-8	2007	Regarding the ER pathway, melatonin attenuated arsenite-induced elevations in activating transcription factor-4, CCAAT/enhancer binding protein (C/EBP) homologues protein, X-bon binding protein (XBP-1) and cytosolic immunoglobulin binding protein (BIP) as well as reductions in procaspase 12 levels.	arsenite	47-55	X-box binding protein 1	Rattus norvegicus	195-200
17645694-8	2007	Regarding the ER pathway, melatonin attenuated arsenite-induced elevations in activating transcription factor-4, CCAAT/enhancer binding protein (C/EBP) homologues protein, X-bon binding protein (XBP-1) and cytosolic immunoglobulin binding protein (BIP) as well as reductions in procaspase 12 levels.	arsenite	47-55	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	248-251
17645694-9	2007	Moreover, aggregation of alpha-synuclein was reduced in the arsenite-infused SN of melatonin-treated rats.	arsenite	60-68	synuclein alpha	Rattus norvegicus	25-40
17626845-11	2007	In further studies, arsenite rapidly induced the formation of stress granules containing HuR and TIA-1 but not AUF1.	arsenite	20-28	ELAV like RNA binding protein 1	Homo sapiens	89-92
17626845-11	2007	In further studies, arsenite rapidly induced the formation of stress granules containing HuR and TIA-1 but not AUF1.	arsenite	20-28	TIA1 cytotoxic granule associated RNA binding protein	Homo sapiens	97-102
17373649-0	2007	Cyclin B1 proteolysis via p38 MAPK signaling participates in G2 checkpoint elicited by arsenite.	arsenite	87-95	cyclin B1	Homo sapiens	0-9
17467962-3	2007	It has been proved that Mrp2 can transport arsenite in vitro, but its effects in vivo are not clear.	arsenite	43-51	ATP binding cassette subfamily B member 4	Rattus norvegicus	24-28
17545210-0	2007	Arsenite slows S phase progression via inhibition of cdc25A dual specificity phosphatase gene transcription.	arsenite	0-8	cell division cycle 25A	Homo sapiens	53-59
17545210-5	2007	Coimmunoprecipitation experiments confirm that cyclin E-cdk2 is more phosphorylated at Thr14 and Tyr15 in the presence of arsenite, and kinase activity assays reveal a decrease in cyclin E-associated cdk2 activity.	arsenite	122-130	cyclin dependent kinase 2	Homo sapiens	56-60
17545210-6	2007	Therefore, arsenite-dependent cdc25A depletion could contribute to S phase inhibition.	arsenite	11-19	cell division cycle 25A	Homo sapiens	30-36
17545210-8	2007	However, cycloheximide half-life assay reveals that cdc25A is actually stabilized in arsenite-treated cells.	arsenite	85-93	cell division cycle 25A	Homo sapiens	52-58
17545210-9	2007	Real-time RT-PCR shows that cdc25A mRNA levels are substantially decreased with arsenite treatment, and actinomycin D half-life assay reveals no change in message stability.	arsenite	80-88	cell division cycle 25A	Homo sapiens	28-34
17545210-10	2007	Decreased cdc25A message translation is shown by sucrose density gradient polysomal analysis to be an unlikely cause for the profound arsenite-dependent reduction in cdc25A protein levels.	arsenite	134-142	cell division cycle 25A	Homo sapiens	166-172
17545210-11	2007	Studies are ongoing to establish the mechanism by which 5 microM arsenite decreases cdc25A message abundance, but we surmise that, given the lack of effect on mRNA stability, an inhibition of gene transcription is likely involved.	arsenite	65-73	cell division cycle 25A	Homo sapiens	84-90
17689208-6	2007	Our results showed that the expression of Bcl-6 increased dose-dependently in arsenite-treated urothelial cells.	arsenite	78-86	BCL6 transcription repressor	Homo sapiens	42-47
17689208-8	2007	However, treatment of SV-HUC-1 cells with arsenite at concentration ranges from 2 and 4microM for 48h dramatically increased p-STAT3 (Tyr 705), but the levels decreased at 8-40microM of arsenite.	arsenite	42-50	signal transducer and activator of transcription 3	Homo sapiens	127-132
17334397-3	2007	Activation of p38 MAPK by arsenite resulted in inactivation of the ERK1,2 signaling pathway by dephosphorylation of MEK1,2 in primary human epidermal keratinocytes (HEKs), whereas in HNSCC cells this p38-mediated inhibition of the ERK1,2 pathway was absent.	arsenite	26-34	mitogen-activated protein kinase 1	Homo sapiens	14-17
17334397-3	2007	Activation of p38 MAPK by arsenite resulted in inactivation of the ERK1,2 signaling pathway by dephosphorylation of MEK1,2 in primary human epidermal keratinocytes (HEKs), whereas in HNSCC cells this p38-mediated inhibition of the ERK1,2 pathway was absent.	arsenite	26-34	mitogen-activated protein kinase 3	Homo sapiens	67-73
17334397-3	2007	Activation of p38 MAPK by arsenite resulted in inactivation of the ERK1,2 signaling pathway by dephosphorylation of MEK1,2 in primary human epidermal keratinocytes (HEKs), whereas in HNSCC cells this p38-mediated inhibition of the ERK1,2 pathway was absent.	arsenite	26-34	mitogen-activated protein kinase kinase 1	Homo sapiens	116-122
17334397-3	2007	Activation of p38 MAPK by arsenite resulted in inactivation of the ERK1,2 signaling pathway by dephosphorylation of MEK1,2 in primary human epidermal keratinocytes (HEKs), whereas in HNSCC cells this p38-mediated inhibition of the ERK1,2 pathway was absent.	arsenite	26-34	mitogen-activated protein kinase 1	Homo sapiens	200-203
17334397-3	2007	Activation of p38 MAPK by arsenite resulted in inactivation of the ERK1,2 signaling pathway by dephosphorylation of MEK1,2 in primary human epidermal keratinocytes (HEKs), whereas in HNSCC cells this p38-mediated inhibition of the ERK1,2 pathway was absent.	arsenite	26-34	mitogen-activated protein kinase 3	Homo sapiens	231-237
17922641-1	2007	Evidence is presented that Tim18, a mitochondria translocase, plays a role in the previously described apoptosis induced by arsenite in Saccharomyces cerevisiae.	arsenite	124-132	Tim18p	Saccharomyces cerevisiae S288C	27-32
17922641-2	2007	Tim18 deletion mutant exhibited resistance to arsenite.	arsenite	46-54	Tim18p	Saccharomyces cerevisiae S288C	0-5
17922641-3	2007	After arsenite treatment, both the wild type and Tim18-deficient cells showed reactive oxygen species (ROS) production.	arsenite	6-14	Tim18p	Saccharomyces cerevisiae S288C	49-54
17922641-4	2007	Arsenite induced the higher expression of tim18 in wild type yeast cells.	arsenite	0-8	Tim18p	Saccharomyces cerevisiae S288C	42-47
17373649-5	2007	Exposing early G(2) cells to arsenite impeded cyclin B1 protein accumulation, Cdk1 activation, and G(2)-to-M progression.	arsenite	29-37	cyclin B1	Homo sapiens	46-55
17373649-5	2007	Exposing early G(2) cells to arsenite impeded cyclin B1 protein accumulation, Cdk1 activation, and G(2)-to-M progression.	arsenite	29-37	cyclin dependent kinase 1	Homo sapiens	78-82
17373649-6	2007	Conversely, cyclin B1 was non-degradable in late G(2) and mitotic cells after arsenite.	arsenite	78-86	cyclin B1	Homo sapiens	12-21
17373649-7	2007	Cyclin B1 proteolysis was enhanced by arsenite in early G(2) and asynchronous cells.	arsenite	38-46	cyclin B1	Homo sapiens	0-9
17373649-0	2007	Cyclin B1 proteolysis via p38 MAPK signaling participates in G2 checkpoint elicited by arsenite.	arsenite	87-95	mitogen-activated protein kinase 14	Homo sapiens	26-29
17373649-9	2007	Under arsenite, inhibition of p38 activation or depletion of p38alpha suppressed cyclin B1 ubiquitination and proteolysis, while forced expression of MKK6-p38 accelerated these events.	arsenite	6-14	mitogen-activated protein kinase 14	Homo sapiens	30-33
17606337-0	2007	Transcriptional activation and posttranscriptional modification of Cyp1a1 by arsenite, cadmium, and chromium.	arsenite	77-85	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	67-73
17373649-9	2007	Under arsenite, inhibition of p38 activation or depletion of p38alpha suppressed cyclin B1 ubiquitination and proteolysis, while forced expression of MKK6-p38 accelerated these events.	arsenite	6-14	cyclin B1	Homo sapiens	81-90
17373649-9	2007	Under arsenite, inhibition of p38 activation or depletion of p38alpha suppressed cyclin B1 ubiquitination and proteolysis, while forced expression of MKK6-p38 accelerated these events.	arsenite	6-14	mitogen-activated protein kinase kinase 6	Homo sapiens	150-154
17373649-10	2007	Inactivation of p38 in arsenite-treated early G(2) cells allowed G(2)-to-M progression, blocked apoptosis, increased cell viability, and decreased micronucleus formation.	arsenite	23-31	mitogen-activated protein kinase 14	Homo sapiens	16-19
17373649-11	2007	Thus, p38 signaling pathway triggering cyclin B1 proteolysis after arsenite may play an important role in connecting G(2) arrest with apoptosis or genome instability.	arsenite	67-75	mitogen-activated protein kinase 14	Homo sapiens	6-9
17373649-11	2007	Thus, p38 signaling pathway triggering cyclin B1 proteolysis after arsenite may play an important role in connecting G(2) arrest with apoptosis or genome instability.	arsenite	67-75	cyclin B1	Homo sapiens	39-48
17416483-10	2007	Using a transfected human hsp 70 promoter-enhanced green fluorescent protein (EGFP) reporter, pHhsp70-EGFP, the induction of HSP70 against oxidative stress-induced apoptosis by arsenite was observed.	arsenite	177-185	heat shock protein family A (Hsp70) member 4	Homo sapiens	125-130
17416483-11	2007	The induction of HSP70 by arsenite increased in a dose-dependent manner, and pretreatment of transfected ZFL cells with NAC or DTT before arsenite insult reduced EGFP expression.	arsenite	26-34	heat shock protein 8-like	Danio rerio	17-22
17616671-1	2007	We have previously shown that trivalent arsenic (arsenite, As(3+)) is able to induce GADD45 alpha expression in human bronchial epithelial cells through activation of c-Jun NH(2)-terminal kinase and nucleolin-dependent mRNA stabilization.	arsenite	49-57	growth arrest and DNA damage inducible alpha	Homo sapiens	85-97
17616671-1	2007	We have previously shown that trivalent arsenic (arsenite, As(3+)) is able to induce GADD45 alpha expression in human bronchial epithelial cells through activation of c-Jun NH(2)-terminal kinase and nucleolin-dependent mRNA stabilization.	arsenite	49-57	nucleolin	Homo sapiens	199-208
17283378-6	2007	At noncytotoxic doses (1-50 micromol/kg arsenite) As strongly suppressed ER-dependent gene transcription of the 17beta-estradiol (E2)-inducible vitellogenin II gene in chick embryo liver in vivo.	arsenite	40-48	vitellogenin 2	Gallus gallus	144-159
17370311-0	2007	PI-3K/Akt signal pathway plays a crucial role in arsenite-induced cell proliferation of human keratinocytes through induction of cyclin D1.	arsenite	49-57	AKT serine/threonine kinase 1	Homo sapiens	6-9
17370311-0	2007	PI-3K/Akt signal pathway plays a crucial role in arsenite-induced cell proliferation of human keratinocytes through induction of cyclin D1.	arsenite	49-57	cyclin D1	Homo sapiens	129-138
17370311-4	2007	Taken together, we provide the direct evidence that PI-3K/Akt pathway plays a role in the regulation of cell proliferation through the induction of cyclin D1 in human keratinocytes upon arsenite treatment.	arsenite	186-194	AKT serine/threonine kinase 1	Homo sapiens	58-61
17370311-4	2007	Taken together, we provide the direct evidence that PI-3K/Akt pathway plays a role in the regulation of cell proliferation through the induction of cyclin D1 in human keratinocytes upon arsenite treatment.	arsenite	186-194	cyclin D1	Homo sapiens	148-157
17370311-5	2007	Given the importance of aberrant cell proliferation in cell transformation, we propose that the activation of PI-3K/Akt pathway and cyclin D1 induction may be the important mediators of human skin carcinogenic effect of arsenite.	arsenite	220-228	AKT serine/threonine kinase 1	Homo sapiens	116-119
17370311-5	2007	Given the importance of aberrant cell proliferation in cell transformation, we propose that the activation of PI-3K/Akt pathway and cyclin D1 induction may be the important mediators of human skin carcinogenic effect of arsenite.	arsenite	220-228	cyclin D1	Homo sapiens	132-141
17479409-0	2007	Arsenite-induced alterations in Ku70-deficient cells: a model to study genotoxic effects.	arsenite	0-8	X-ray repair cross complementing 6	Homo sapiens	32-36
17327492-8	2007	Taken together, our data reveal that arsenite-exposed cells channel a large part of assimilated sulfur into glutathione biosynthesis, and we provide evidence that the transcriptional regulators Yap1p and Met4p control this response in concert.	arsenite	37-45	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	194-199
17327492-8	2007	Taken together, our data reveal that arsenite-exposed cells channel a large part of assimilated sulfur into glutathione biosynthesis, and we provide evidence that the transcriptional regulators Yap1p and Met4p control this response in concert.	arsenite	37-45	Met4p	Saccharomyces cerevisiae S288C	204-209
17292378-0	2007	Adsorption of arsenite and arsenate onto muscovite and biotite mica.	arsenite	14-22	MHC class I polypeptide-related sequence A	Homo sapiens	63-67
17520061-0	2007	Molecular mechanisms of the diabetogenic effects of arsenic: inhibition of insulin signaling by arsenite and methylarsonous acid.	arsenite	96-104	insulin	Homo sapiens	75-82
17400267-0	2007	Arsenite and insulin exhibit opposing effects on epidermal growth factor receptor and keratinocyte proliferative potential.	arsenite	0-8	epidermal growth factor receptor	Homo sapiens	49-81
17400267-2	2007	To find a molecular basis for this action, present work has explored the influence of arsenite on keratinocyte responses to epidermal growth factor (EGF).	arsenite	86-94	epidermal growth factor	Homo sapiens	124-147
17400267-2	2007	To find a molecular basis for this action, present work has explored the influence of arsenite on keratinocyte responses to epidermal growth factor (EGF).	arsenite	86-94	epidermal growth factor	Homo sapiens	149-152
17400267-4	2007	Arsenite prevented the loss of EGF receptor protein and phosphorylation of tyrosine 1173, preserving its capability to signal.	arsenite	0-8	epidermal growth factor receptor	Homo sapiens	31-43
17400267-5	2007	The level of nuclear beta-catenin was higher in cells treated with arsenite and EGF in parallel to elevated colony forming ability, and expression of a dominant negative beta-catenin suppressed the increase in both colony forming ability and yield of putative stem cells induced by arsenite and EGF.	arsenite	67-75	catenin beta 1	Homo sapiens	21-33
17400267-5	2007	The level of nuclear beta-catenin was higher in cells treated with arsenite and EGF in parallel to elevated colony forming ability, and expression of a dominant negative beta-catenin suppressed the increase in both colony forming ability and yield of putative stem cells induced by arsenite and EGF.	arsenite	67-75	catenin beta 1	Homo sapiens	170-182
17400267-5	2007	The level of nuclear beta-catenin was higher in cells treated with arsenite and EGF in parallel to elevated colony forming ability, and expression of a dominant negative beta-catenin suppressed the increase in both colony forming ability and yield of putative stem cells induced by arsenite and EGF.	arsenite	67-75	epidermal growth factor	Homo sapiens	295-298
17400267-5	2007	The level of nuclear beta-catenin was higher in cells treated with arsenite and EGF in parallel to elevated colony forming ability, and expression of a dominant negative beta-catenin suppressed the increase in both colony forming ability and yield of putative stem cells induced by arsenite and EGF.	arsenite	282-290	catenin beta 1	Homo sapiens	21-33
17400267-5	2007	The level of nuclear beta-catenin was higher in cells treated with arsenite and EGF in parallel to elevated colony forming ability, and expression of a dominant negative beta-catenin suppressed the increase in both colony forming ability and yield of putative stem cells induced by arsenite and EGF.	arsenite	282-290	epidermal growth factor	Homo sapiens	80-83
17400267-5	2007	The level of nuclear beta-catenin was higher in cells treated with arsenite and EGF in parallel to elevated colony forming ability, and expression of a dominant negative beta-catenin suppressed the increase in both colony forming ability and yield of putative stem cells induced by arsenite and EGF.	arsenite	282-290	catenin beta 1	Homo sapiens	170-182
17400267-6	2007	As judged by expression of three genes regulated by beta-catenin, this transcription factor had substantially higher activity in the arsenite/EGF-treated cells.	arsenite	133-141	catenin beta 1	Homo sapiens	52-64
17400267-6	2007	As judged by expression of three genes regulated by beta-catenin, this transcription factor had substantially higher activity in the arsenite/EGF-treated cells.	arsenite	133-141	epidermal growth factor	Homo sapiens	142-145
17400267-8	2007	A novel finding is that insulin in the medium induced the loss of EGF receptor protein, which was largely prevented by arsenite exposure.	arsenite	119-127	insulin	Homo sapiens	24-31
17400267-8	2007	A novel finding is that insulin in the medium induced the loss of EGF receptor protein, which was largely prevented by arsenite exposure.	arsenite	119-127	epidermal growth factor receptor	Homo sapiens	66-78
17520061-3	2007	We have previously shown that trivalent metabolites of iAs, arsenite (iAs(III)) and methylarsonous acid (MAs(III)) inhibit insulin-stimulated glucose uptake (ISGU) in 3T3-L1 adipocytes by suppressing the insulin-dependent phosphorylation of protein kinase B (PKB/Akt).	arsenite	60-68	insulin	Homo sapiens	123-130
17520061-3	2007	We have previously shown that trivalent metabolites of iAs, arsenite (iAs(III)) and methylarsonous acid (MAs(III)) inhibit insulin-stimulated glucose uptake (ISGU) in 3T3-L1 adipocytes by suppressing the insulin-dependent phosphorylation of protein kinase B (PKB/Akt).	arsenite	60-68	insulin	Homo sapiens	204-211
17520061-3	2007	We have previously shown that trivalent metabolites of iAs, arsenite (iAs(III)) and methylarsonous acid (MAs(III)) inhibit insulin-stimulated glucose uptake (ISGU) in 3T3-L1 adipocytes by suppressing the insulin-dependent phosphorylation of protein kinase B (PKB/Akt).	arsenite	60-68	AKT serine/threonine kinase 1	Homo sapiens	259-262
17520061-3	2007	We have previously shown that trivalent metabolites of iAs, arsenite (iAs(III)) and methylarsonous acid (MAs(III)) inhibit insulin-stimulated glucose uptake (ISGU) in 3T3-L1 adipocytes by suppressing the insulin-dependent phosphorylation of protein kinase B (PKB/Akt).	arsenite	60-68	AKT serine/threonine kinase 1	Homo sapiens	263-266
17339575-10	2007	In cells subjected to arsenite-induced oxidative stress, YB-1 localized to TIA-containing stress granules.	arsenite	22-30	Y-box binding protein 1	Homo sapiens	57-61
17161839-5	2007	To address this, the effect of miltefosine in arsenite-resistant Leishmania donovani (Ld-As20) promastigotes displaying an MDR phenotype and overexpressing Pgp-like protein was investigated in the current study.	arsenite	46-54	p-glycoprotein	Leishmania donovani	156-159
17185630-8	2007	Induction of HSP70 with arsenite resulted in a >50% reduction in liver injury as determined by serum transaminases and histology.	arsenite	24-32	heat shock protein 1B	Mus musculus	13-18
17185630-9	2007	In addition, arsenite similarly reduced liver neutrophil recruitment and liver nuclear factor-kappaB activation, and attenuated serum levels of tumor necrosis factor-alpha and macrophage inflammatory protein-2, but increased levels of interleukin (IL)-6.	arsenite	13-21	tumor necrosis factor	Mus musculus	144-171
17185630-9	2007	In addition, arsenite similarly reduced liver neutrophil recruitment and liver nuclear factor-kappaB activation, and attenuated serum levels of tumor necrosis factor-alpha and macrophage inflammatory protein-2, but increased levels of interleukin (IL)-6.	arsenite	13-21	chemokine (C-X-C motif) ligand 2	Mus musculus	176-209
17185630-9	2007	In addition, arsenite similarly reduced liver neutrophil recruitment and liver nuclear factor-kappaB activation, and attenuated serum levels of tumor necrosis factor-alpha and macrophage inflammatory protein-2, but increased levels of interleukin (IL)-6.	arsenite	13-21	interleukin 6	Mus musculus	235-253
17185630-10	2007	In HSP70 knockout mice, arsenite did not protect against liver injury but did reduce liver neutrophil accumulation.	arsenite	24-32	heat shock protein 1B	Mus musculus	3-8
17185630-11	2007	Arsenite-induced reductions in neutrophil accumulation in HSP70 knockout mice were found to be mediated by IL-6.	arsenite	0-8	heat shock protein 1B	Mus musculus	58-63
17185630-11	2007	Arsenite-induced reductions in neutrophil accumulation in HSP70 knockout mice were found to be mediated by IL-6.	arsenite	0-8	interleukin 6	Mus musculus	107-111
17450217-0	2007	Cyclooxygenase-2 induction by arsenite through the IKKbeta/NFkappaB pathway exerts an antiapoptotic effect in mouse epidermal Cl41 cells.	arsenite	30-38	inhibitor of kappaB kinase beta	Mus musculus	51-58
17009048-2	2007	However, the effects of arsenite on IL-2 mRNA expression or on the ERK pathway in activated-T cells have not yet been described.	arsenite	24-32	interleukin 2	Mus musculus	36-40
17009048-3	2007	We examined the effect of arsenite on IL-2 mRNA expression, cell activation and proliferation in PHA-stimulated murine lymphocytes.	arsenite	26-34	interleukin 2	Mus musculus	38-42
17009048-4	2007	Arsenite (1 and 10 microM) decreased IL-2 mRNA expression, IL-2 secretion and cell proliferation.	arsenite	0-8	interleukin 2	Mus musculus	37-41
17009048-4	2007	Arsenite (1 and 10 microM) decreased IL-2 mRNA expression, IL-2 secretion and cell proliferation.	arsenite	0-8	interleukin 2	Mus musculus	59-63
17009048-5	2007	Arsenite (10 microM) strongly inhibited ERK-phosphorylation.	arsenite	0-8	mitogen-activated protein kinase 1	Mus musculus	40-43
17009048-8	2007	Arsenite also decreased early activation (surface CD69+ expression) in both CD4+ and CD8+, and decreased total CD8+ count without significantly affecting CD4+, supporting that the cellular immune response mediated by cytotoxic T cells is an arsenic target.	arsenite	0-8	CD4 antigen	Mus musculus	76-79
17009048-9	2007	Thus, our results suggest that arsenite decreases IL-2 mRNA levels and T-cell activation and proliferation.	arsenite	31-39	interleukin 2	Mus musculus	50-54
17009048-10	2007	However, further studies on the effects of arsenite on IL-2 gene transcription and IL-2 mRNA stability are needed.	arsenite	43-51	interleukin 2	Mus musculus	55-59
17450217-0	2007	Cyclooxygenase-2 induction by arsenite through the IKKbeta/NFkappaB pathway exerts an antiapoptotic effect in mouse epidermal Cl41 cells.	arsenite	30-38	prostaglandin-endoperoxide synthase 2	Mus musculus	0-16
17450217-0	2007	Cyclooxygenase-2 induction by arsenite through the IKKbeta/NFkappaB pathway exerts an antiapoptotic effect in mouse epidermal Cl41 cells.	arsenite	30-38	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	59-67
17450217-4	2007	OBJECTIVES: In the present study we evaluated cyclooxygenase-2 (COX-2) expression, the signaling pathways leading to COX-2 induction, and its antiapoptotic function in the response to arsenite exposure in mouse epidermal JB6 Cl41 cells.	arsenite	184-192	prostaglandin-endoperoxide synthase 2	Mus musculus	46-62
17450217-5	2007	METHODS: We used the luciferase reporter assay and Western blots to determine COX-2 induction by arsenite.	arsenite	97-105	prostaglandin-endoperoxide synthase 2	Mus musculus	78-83
17450217-7	2007	RESULTS: The induction of COX-2 by arsenite was inhibited in Cl41 cells transfected with IKKbeta-KM, a dominant mutant inhibitor of kbeta (Ikbeta) kinase (IKKbeta), and in IKKbeta-knockout (IKKbeta(-/-)) mouse embryonic fibroblasts (MEFs).	arsenite	35-43	prostaglandin-endoperoxide synthase 2	Mus musculus	26-31
17450217-7	2007	RESULTS: The induction of COX-2 by arsenite was inhibited in Cl41 cells transfected with IKKbeta-KM, a dominant mutant inhibitor of kbeta (Ikbeta) kinase (IKKbeta), and in IKKbeta-knockout (IKKbeta(-/-)) mouse embryonic fibroblasts (MEFs).	arsenite	35-43	inhibitor of kappaB kinase beta	Mus musculus	89-96
17450217-7	2007	RESULTS: The induction of COX-2 by arsenite was inhibited in Cl41 cells transfected with IKKbeta-KM, a dominant mutant inhibitor of kbeta (Ikbeta) kinase (IKKbeta), and in IKKbeta-knockout (IKKbeta(-/-)) mouse embryonic fibroblasts (MEFs).	arsenite	35-43	inhibitor of kappaB kinase beta	Mus musculus	155-162
17450217-7	2007	RESULTS: The induction of COX-2 by arsenite was inhibited in Cl41 cells transfected with IKKbeta-KM, a dominant mutant inhibitor of kbeta (Ikbeta) kinase (IKKbeta), and in IKKbeta-knockout (IKKbeta(-/-)) mouse embryonic fibroblasts (MEFs).	arsenite	35-43	inhibitor of kappaB kinase beta	Mus musculus	155-162
17450217-7	2007	RESULTS: The induction of COX-2 by arsenite was inhibited in Cl41 cells transfected with IKKbeta-KM, a dominant mutant inhibitor of kbeta (Ikbeta) kinase (IKKbeta), and in IKKbeta-knockout (IKKbeta(-/-)) mouse embryonic fibroblasts (MEFs).	arsenite	35-43	inhibitor of kappaB kinase beta	Mus musculus	155-162
17450217-8	2007	IKKbeta/nuclear factor kappaB (NFkappaB) pathway-mediated COX-2 induction exerted an antiapoptotic effect on the cells exposed to arsenite because cell apoptosis was significantly enhanced in the Cl41 cells transfected with IKKbeta-KM or COX-2 small interference RNA (siCOX-2).	arsenite	130-138	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-29
17450217-8	2007	IKKbeta/nuclear factor kappaB (NFkappaB) pathway-mediated COX-2 induction exerted an antiapoptotic effect on the cells exposed to arsenite because cell apoptosis was significantly enhanced in the Cl41 cells transfected with IKKbeta-KM or COX-2 small interference RNA (siCOX-2).	arsenite	130-138	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	31-39
17450217-8	2007	IKKbeta/nuclear factor kappaB (NFkappaB) pathway-mediated COX-2 induction exerted an antiapoptotic effect on the cells exposed to arsenite because cell apoptosis was significantly enhanced in the Cl41 cells transfected with IKKbeta-KM or COX-2 small interference RNA (siCOX-2).	arsenite	130-138	prostaglandin-endoperoxide synthase 2	Mus musculus	58-63
17450217-8	2007	IKKbeta/nuclear factor kappaB (NFkappaB) pathway-mediated COX-2 induction exerted an antiapoptotic effect on the cells exposed to arsenite because cell apoptosis was significantly enhanced in the Cl41 cells transfected with IKKbeta-KM or COX-2 small interference RNA (siCOX-2).	arsenite	130-138	inhibitor of kappaB kinase beta	Mus musculus	0-7
17450217-8	2007	IKKbeta/nuclear factor kappaB (NFkappaB) pathway-mediated COX-2 induction exerted an antiapoptotic effect on the cells exposed to arsenite because cell apoptosis was significantly enhanced in the Cl41 cells transfected with IKKbeta-KM or COX-2 small interference RNA (siCOX-2).	arsenite	130-138	prostaglandin-endoperoxide synthase 2	Mus musculus	238-243
17450217-9	2007	In addition, IKKbeta(-/-) MEFs stably transfected with COX-2 showed more resistance to arsenite-induced apoptosis compared with the same control vector-transfected cells.	arsenite	87-95	inhibitor of kappaB kinase beta	Mus musculus	13-20
17450217-9	2007	In addition, IKKbeta(-/-) MEFs stably transfected with COX-2 showed more resistance to arsenite-induced apoptosis compared with the same control vector-transfected cells.	arsenite	87-95	prostaglandin-endoperoxide synthase 2	Mus musculus	55-60
17450217-10	2007	CONCLUSIONS: These results demonstrate that arsenite exposure can induce COX-2 expression through the IKKbeta/NFkappaB pathway, which thereby exerts an antiapoptotic effect in response to arsenite.	arsenite	44-52	prostaglandin-endoperoxide synthase 2	Mus musculus	73-78
17450217-10	2007	CONCLUSIONS: These results demonstrate that arsenite exposure can induce COX-2 expression through the IKKbeta/NFkappaB pathway, which thereby exerts an antiapoptotic effect in response to arsenite.	arsenite	44-52	inhibitor of kappaB kinase beta	Mus musculus	102-109
17450217-10	2007	CONCLUSIONS: These results demonstrate that arsenite exposure can induce COX-2 expression through the IKKbeta/NFkappaB pathway, which thereby exerts an antiapoptotic effect in response to arsenite.	arsenite	44-52	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	110-118
17450217-10	2007	CONCLUSIONS: These results demonstrate that arsenite exposure can induce COX-2 expression through the IKKbeta/NFkappaB pathway, which thereby exerts an antiapoptotic effect in response to arsenite.	arsenite	188-196	prostaglandin-endoperoxide synthase 2	Mus musculus	73-78
17450217-10	2007	CONCLUSIONS: These results demonstrate that arsenite exposure can induce COX-2 expression through the IKKbeta/NFkappaB pathway, which thereby exerts an antiapoptotic effect in response to arsenite.	arsenite	188-196	inhibitor of kappaB kinase beta	Mus musculus	102-109
17450217-10	2007	CONCLUSIONS: These results demonstrate that arsenite exposure can induce COX-2 expression through the IKKbeta/NFkappaB pathway, which thereby exerts an antiapoptotic effect in response to arsenite.	arsenite	188-196	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	110-118
17450217-11	2007	In light of the importance of apoptosis evasion during carcinogenesis, we anticipate that COX-2 induction may be at least partially responsible for the carcinogenic effect of arsenite on skin.	arsenite	175-183	prostaglandin-endoperoxide synthase 2	Mus musculus	90-95
17450228-8	2007	Validation of the putative biomarkers was carried out by evaluating As-induced alterations in RAGE in humans.	arsenite	68-70	advanced glycosylation end-product specific receptor	Homo sapiens	94-98
17450228-9	2007	Regression analysis demonstrated a significant negative correlation (p = 0.016) between sputum levels of RAGE and total urinary inorganic As, similar to results seen in our animal model.	arsenite	138-140	advanced glycosylation end-product specific receptor	Homo sapiens	105-109
17289100-0	2007	Biphasic effect of arsenite on cell proliferation and apoptosis is associated with the activation of JNK and ERK1/2 in human embryo lung fibroblast cells.	arsenite	19-27	mitogen-activated protein kinase 8	Homo sapiens	101-104
17289100-0	2007	Biphasic effect of arsenite on cell proliferation and apoptosis is associated with the activation of JNK and ERK1/2 in human embryo lung fibroblast cells.	arsenite	19-27	mitogen-activated protein kinase 3	Homo sapiens	109-115
17289100-3	2007	In the present study, we aimed at investigating the relationship between biphasic effect of arsenite on cell proliferation and apoptosis and activation of JNK and ERK1/2 in human embryo lung fibroblast (HELF) cells.	arsenite	92-100	mitogen-activated protein kinase 8	Homo sapiens	155-158
17289100-3	2007	In the present study, we aimed at investigating the relationship between biphasic effect of arsenite on cell proliferation and apoptosis and activation of JNK and ERK1/2 in human embryo lung fibroblast (HELF) cells.	arsenite	92-100	mitogen-activated protein kinase 3	Homo sapiens	163-169
17289100-6	2007	During stimulation phospho-JNK levels were significantly increased at 3, 6, and 12 h after 0.1 or 0.5 microM arsenite exposure.	arsenite	109-117	mitogen-activated protein kinase 8	Homo sapiens	27-30
17289100-7	2007	Phospho-ERK1/2 levels were increased with different concentrations (0.1-10 microM) of arsenite at 6, 12, and 24 h. Blocking of JNK pathway with 20 microM SP600125 or ERK1/2 by 100 microM PD98059 significantly inhibited biphasic effect of arsenite in cells.	arsenite	86-94	mitogen-activated protein kinase 3	Homo sapiens	8-14
17289100-7	2007	Phospho-ERK1/2 levels were increased with different concentrations (0.1-10 microM) of arsenite at 6, 12, and 24 h. Blocking of JNK pathway with 20 microM SP600125 or ERK1/2 by 100 microM PD98059 significantly inhibited biphasic effect of arsenite in cells.	arsenite	86-94	mitogen-activated protein kinase 8	Homo sapiens	127-130
17289100-7	2007	Phospho-ERK1/2 levels were increased with different concentrations (0.1-10 microM) of arsenite at 6, 12, and 24 h. Blocking of JNK pathway with 20 microM SP600125 or ERK1/2 by 100 microM PD98059 significantly inhibited biphasic effect of arsenite in cells.	arsenite	86-94	mitogen-activated protein kinase 3	Homo sapiens	166-172
17289100-7	2007	Phospho-ERK1/2 levels were increased with different concentrations (0.1-10 microM) of arsenite at 6, 12, and 24 h. Blocking of JNK pathway with 20 microM SP600125 or ERK1/2 by 100 microM PD98059 significantly inhibited biphasic effect of arsenite in cells.	arsenite	238-246	mitogen-activated protein kinase 3	Homo sapiens	8-14
17289100-7	2007	Phospho-ERK1/2 levels were increased with different concentrations (0.1-10 microM) of arsenite at 6, 12, and 24 h. Blocking of JNK pathway with 20 microM SP600125 or ERK1/2 by 100 microM PD98059 significantly inhibited biphasic effect of arsenite in cells.	arsenite	238-246	mitogen-activated protein kinase 8	Homo sapiens	127-130
17289100-7	2007	Phospho-ERK1/2 levels were increased with different concentrations (0.1-10 microM) of arsenite at 6, 12, and 24 h. Blocking of JNK pathway with 20 microM SP600125 or ERK1/2 by 100 microM PD98059 significantly inhibited biphasic effect of arsenite in cells.	arsenite	238-246	mitogen-activated protein kinase 3	Homo sapiens	166-172
17289100-8	2007	Data in the present study suggest that activation of JNK and ERK1/2 may be involved in biphasic effect of arsenite when measuring cell proliferation and apoptosis in HELF cells.	arsenite	106-114	mitogen-activated protein kinase 8	Homo sapiens	53-56
17289100-8	2007	Data in the present study suggest that activation of JNK and ERK1/2 may be involved in biphasic effect of arsenite when measuring cell proliferation and apoptosis in HELF cells.	arsenite	106-114	mitogen-activated protein kinase 3	Homo sapiens	61-67
17431482-10	2007	CONCLUSIONS: These results suggest that arsenite and MMA(III) are key metabolites that trigger higher levels of TrxR1, and both lead to a reduction in the expression of cGpx.	arsenite	40-48	thioredoxin reductase 1	Homo sapiens	112-117
17196236-6	2007	Inhibition of EGF receptor, MEK I/II or Src decreased arsenite-stimulated HO-1 expression by 20-30%.	arsenite	54-62	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	40-43
17284590-2	2007	We show here that cell stress such as arsenite exposure induces phosphorylation of RBM4 at serine 309 and also drives its cytoplasmic accumulation and targeting to stress granule via the MKK(3/6)-p38 signaling pathway.	arsenite	38-46	RNA binding motif protein 4	Homo sapiens	83-87
17284590-6	2007	Whereas arsenite treatment promotes RBM4 loading onto IRES mRNAs and enhances RBM4-eIF4A interactions, a nonphosphorylatable mutant of RBM4 was unresponsive to arsenite stress and failed to activate IRES-mediated translation.	arsenite	8-16	RNA binding motif protein 4	Homo sapiens	36-40
17284590-6	2007	Whereas arsenite treatment promotes RBM4 loading onto IRES mRNAs and enhances RBM4-eIF4A interactions, a nonphosphorylatable mutant of RBM4 was unresponsive to arsenite stress and failed to activate IRES-mediated translation.	arsenite	8-16	RNA binding motif protein 4	Homo sapiens	78-82
17284590-6	2007	Whereas arsenite treatment promotes RBM4 loading onto IRES mRNAs and enhances RBM4-eIF4A interactions, a nonphosphorylatable mutant of RBM4 was unresponsive to arsenite stress and failed to activate IRES-mediated translation.	arsenite	8-16	eukaryotic translation initiation factor 4A1	Homo sapiens	83-88
17284590-6	2007	Whereas arsenite treatment promotes RBM4 loading onto IRES mRNAs and enhances RBM4-eIF4A interactions, a nonphosphorylatable mutant of RBM4 was unresponsive to arsenite stress and failed to activate IRES-mediated translation.	arsenite	8-16	RNA binding motif protein 4	Homo sapiens	78-82
17306216-0	2007	The NT-26 cytochrome c552 and its role in arsenite oxidation.	arsenite	42-50	cytochrome c, somatic	Equus caballus	10-22
17200139-4	2007	We show that Yap8p is stabilized in arsenite-exposed cells in a time- and dose-dependent manner.	arsenite	36-44	Arr1p	Saccharomyces cerevisiae S288C	13-18
17200139-8	2007	Instead, arsenite-stimulated Yap8p stabilization and transcriptional activation of ACR3 requires critical cysteine residues within Yap8p.	arsenite	9-17	Arr1p	Saccharomyces cerevisiae S288C	29-34
17200139-8	2007	Instead, arsenite-stimulated Yap8p stabilization and transcriptional activation of ACR3 requires critical cysteine residues within Yap8p.	arsenite	9-17	Arr3p	Saccharomyces cerevisiae S288C	83-87
17200139-8	2007	Instead, arsenite-stimulated Yap8p stabilization and transcriptional activation of ACR3 requires critical cysteine residues within Yap8p.	arsenite	9-17	Arr1p	Saccharomyces cerevisiae S288C	131-136
17200139-9	2007	Collectively, our data is consistent with a model where Yap8p is degraded by the ubiquitin-proteasome pathway in untreated cells, whereas arsenite-exposure results in Yap8p stabilization and gene activation.	arsenite	138-146	Arr1p	Saccharomyces cerevisiae S288C	167-172
17101720-0	2007	8-Oxoguanine DNA glycosylase and MutY homolog are involved in the incision of arsenite-induced DNA adducts.	arsenite	78-86	8-oxoguanine DNA glycosylase	Homo sapiens	0-28
17196236-7	2007	In contrast, addition of a superoxide scavenger or inhibition of p38 activity decreased the arsenite-dependent response by 80-90% suggesting that ROS and p38 are required for HO-1 induction.	arsenite	92-100	mitogen-activated protein kinase 14	Homo sapiens	65-68
17196236-7	2007	In contrast, addition of a superoxide scavenger or inhibition of p38 activity decreased the arsenite-dependent response by 80-90% suggesting that ROS and p38 are required for HO-1 induction.	arsenite	92-100	mitogen-activated protein kinase 14	Homo sapiens	154-157
17196236-9	2007	Cooperation between ERK signaling and ROS generation was demonstrated by synergistic induction of HO-1 in cells co-treated with EGF and xanthine/xanthine oxidase resulting in a response nearly equivalent to that observed with arsenite.	arsenite	226-234	mitogen-activated protein kinase 1	Homo sapiens	20-23
17196236-10	2007	These findings suggest that the ERK/MAPK activation is necessary but not sufficient for optimal arsenite-stimulated HO-1 induction.	arsenite	96-104	mitogen-activated protein kinase 1	Homo sapiens	32-35
17939155-7	2007	Determination of binding constants indicated that affinity to Trx was higher for monomethylarsonous acid (MMA(III)) and phenylarsine oxide (PhAs(III)) than inorganic arsenite (iAs(III)) and dimethylarsinous acid (DMA(III)), probably because MMA(III) and PhAs(III) were able to form stable complexes by binding to two vicinal cysteines in the -CysGlyProCys- region of the Trx.	arsenite	166-174	thioredoxin	Homo sapiens	62-65
17011244-0	2007	Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cells.	arsenite	10-18	poly(ADP-ribose) polymerase 1	Homo sapiens	53-59
17645930-3	2007	However, a similarity between hyperthermic- and arsenite-induced brain patterns of Hsp70 expression supports the view that denaturation of specific proteins plays a major role in the selectivity of glial/vascular expression also during hyperthermia in vivo.	arsenite	48-56	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	83-88
17188940-3	2007	Arsenite exposure led to a significant depletion of blood delta-aminolevulinic acid dehydratase (ALAD) activity, glutathione and platelet levels while significantly increased the level of reactive oxygen species (in RBCs).	arsenite	0-8	aminolevulinate dehydratase	Rattus norvegicus	58-95
17188940-3	2007	Arsenite exposure led to a significant depletion of blood delta-aminolevulinic acid dehydratase (ALAD) activity, glutathione and platelet levels while significantly increased the level of reactive oxygen species (in RBCs).	arsenite	0-8	aminolevulinate dehydratase	Rattus norvegicus	97-101
17942419-4	2007	HMOX1 induction, elicited by arsenite-mediated oxidative stress, follows inactivation of BACH1 and precedes activation of NRF2.	arsenite	29-37	heme oxygenase 1	Homo sapiens	0-5
17083955-1	2006	Previous work in our laboratory has shown that acute exposure of primary rat hepatocyte cultures to non-toxic concentrations of arsenite causes major decreases in the DEX-mediated induction of CYP3A23 protein, with minor decreases in CYP3A23 mRNA.	arsenite	128-136	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	193-200
17083955-1	2006	Previous work in our laboratory has shown that acute exposure of primary rat hepatocyte cultures to non-toxic concentrations of arsenite causes major decreases in the DEX-mediated induction of CYP3A23 protein, with minor decreases in CYP3A23 mRNA.	arsenite	128-136	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	234-241
17083955-8	2006	These results suggest that arsenite and lactacystin act by similar mechanisms to inhibit translation of CYP3A23.	arsenite	27-35	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	104-111
17082820-7	2006	We also show that PLIC-1 is upregulated by arsenite-induced protein misfolding.	arsenite	43-51	ubiquilin 1	Homo sapiens	18-24
16645841-0	2006	ATM/ATR-related checkpoint signals mediate arsenite-induced G2/M arrest in primary aortic endothelial cells.	arsenite	43-51	ATM serine/threonine kinase	Homo sapiens	0-3
16645841-0	2006	ATM/ATR-related checkpoint signals mediate arsenite-induced G2/M arrest in primary aortic endothelial cells.	arsenite	43-51	ATR serine/threonine kinase	Homo sapiens	4-7
16645841-6	2006	We found that this arsenite-induced G2/M phase arrest was accompanied by accumulation and/or phosphorylation of checkpoint-related molecules, including p53, Cdc25B, Cdc25C, and securin.	arsenite	19-27	tumor protein p53	Homo sapiens	152-155
16645841-6	2006	We found that this arsenite-induced G2/M phase arrest was accompanied by accumulation and/or phosphorylation of checkpoint-related molecules, including p53, Cdc25B, Cdc25C, and securin.	arsenite	19-27	cell division cycle 25B	Homo sapiens	157-163
16645841-6	2006	We found that this arsenite-induced G2/M phase arrest was accompanied by accumulation and/or phosphorylation of checkpoint-related molecules, including p53, Cdc25B, Cdc25C, and securin.	arsenite	19-27	cell division cycle 25C	Homo sapiens	165-171
16645841-6	2006	We found that this arsenite-induced G2/M phase arrest was accompanied by accumulation and/or phosphorylation of checkpoint-related molecules, including p53, Cdc25B, Cdc25C, and securin.	arsenite	19-27	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	177-184
16645841-8	2006	Our data suggest that the DNA damage responsive kinases ATM (ataxia-telangiectasia mutated) and ATR (ATM and Rad3-related) play critical roles in arsenite-induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint-related signaling molecules including p53, Cdc25B, Cdc25C, and securin.	arsenite	146-154	ATM serine/threonine kinase	Homo sapiens	56-90
16645841-8	2006	Our data suggest that the DNA damage responsive kinases ATM (ataxia-telangiectasia mutated) and ATR (ATM and Rad3-related) play critical roles in arsenite-induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint-related signaling molecules including p53, Cdc25B, Cdc25C, and securin.	arsenite	146-154	ATR serine/threonine kinase	Homo sapiens	96-99
16645841-8	2006	Our data suggest that the DNA damage responsive kinases ATM (ataxia-telangiectasia mutated) and ATR (ATM and Rad3-related) play critical roles in arsenite-induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint-related signaling molecules including p53, Cdc25B, Cdc25C, and securin.	arsenite	146-154	ATM serine/threonine kinase	Homo sapiens	56-59
16645841-8	2006	Our data suggest that the DNA damage responsive kinases ATM (ataxia-telangiectasia mutated) and ATR (ATM and Rad3-related) play critical roles in arsenite-induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint-related signaling molecules including p53, Cdc25B, Cdc25C, and securin.	arsenite	146-154	tumor protein p53	Homo sapiens	285-288
16645841-8	2006	Our data suggest that the DNA damage responsive kinases ATM (ataxia-telangiectasia mutated) and ATR (ATM and Rad3-related) play critical roles in arsenite-induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint-related signaling molecules including p53, Cdc25B, Cdc25C, and securin.	arsenite	146-154	cell division cycle 25B	Homo sapiens	290-296
16645841-8	2006	Our data suggest that the DNA damage responsive kinases ATM (ataxia-telangiectasia mutated) and ATR (ATM and Rad3-related) play critical roles in arsenite-induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint-related signaling molecules including p53, Cdc25B, Cdc25C, and securin.	arsenite	146-154	cell division cycle 25C	Homo sapiens	298-304
16645841-8	2006	Our data suggest that the DNA damage responsive kinases ATM (ataxia-telangiectasia mutated) and ATR (ATM and Rad3-related) play critical roles in arsenite-induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint-related signaling molecules including p53, Cdc25B, Cdc25C, and securin.	arsenite	146-154	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	310-317
17070520-6	2006	Arsenite treatment upregulated surface levels of death receptors, TRAIL-R1 and TRAIL-R2, through increased translocation of these proteins from cytoplasm to the cell surface.	arsenite	0-8	TNF receptor superfamily member 10a	Homo sapiens	66-74
17070520-6	2006	Arsenite treatment upregulated surface levels of death receptors, TRAIL-R1 and TRAIL-R2, through increased translocation of these proteins from cytoplasm to the cell surface.	arsenite	0-8	TNF receptor superfamily member 10b	Homo sapiens	79-87
17070520-8	2006	Direct suppression of cFLIP expression by cFLIP RNAi also accelerated TRAIL-induced apoptosis in these melanomas, while COX-2 suppression substantially increased levels of both TRAIL-induced and arsenite-induced apoptosis.	arsenite	195-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
17145805-0	2006	Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells.	arsenite	102-110	PDZ binding kinase	Homo sapiens	0-60
17145805-0	2006	Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells.	arsenite	102-110	H2A.X variant histone	Homo sapiens	80-92
17145805-6	2006	RESULTS: Melanoma cell lines expressing high levels of TOPK were more resistant to arsenite (As(3+))-induced apoptosis.	arsenite	83-91	PDZ binding kinase	Homo sapiens	55-59
17005224-0	2006	Induction of cyclin D1 by submicromolar concentrations of arsenite in human epidermal keratinocytes.	arsenite	58-66	cyclin D1	Homo sapiens	13-22
16982678-5	2006	Arsenite stress disrupts the polysome binding of PMR1 and its substrate mRNA but has no impact on the critical tyrosine phosphorylation of PMR1, its association with substrate mRNA, or its association with the functional approximately 680-kDa mRNP complex in which it normally resides on polysomes.	arsenite	0-8	ATPase secretory pathway Ca2+ transporting 1	Homo sapiens	49-53
16982678-6	2006	We show that arsenite stress drives PMR1 into an RNase-resistant complex with TIA-1, and we identify a distinct domain in the N terminus of PMR1 that facilitates its interaction with TIA-1.	arsenite	13-21	ATPase secretory pathway Ca2+ transporting 1	Homo sapiens	36-40
16982678-6	2006	We show that arsenite stress drives PMR1 into an RNase-resistant complex with TIA-1, and we identify a distinct domain in the N terminus of PMR1 that facilitates its interaction with TIA-1.	arsenite	13-21	TIA1 cytotoxic granule associated RNA binding protein	Homo sapiens	78-83
16982678-6	2006	We show that arsenite stress drives PMR1 into an RNase-resistant complex with TIA-1, and we identify a distinct domain in the N terminus of PMR1 that facilitates its interaction with TIA-1.	arsenite	13-21	ATPase secretory pathway Ca2+ transporting 1	Homo sapiens	140-144
16982678-6	2006	We show that arsenite stress drives PMR1 into an RNase-resistant complex with TIA-1, and we identify a distinct domain in the N terminus of PMR1 that facilitates its interaction with TIA-1.	arsenite	13-21	TIA1 cytotoxic granule associated RNA binding protein	Homo sapiens	183-188
16982678-7	2006	Finally, we show that arsenite promotes the delayed association of PMR1 with SGs under conditions which cause tristetraprolin and butyrate response factor 1, proteins that facilitate exonucleolytic mRNA, to exit SGs.	arsenite	22-30	ATPase secretory pathway Ca2+ transporting 1	Homo sapiens	67-71
16982678-7	2006	Finally, we show that arsenite promotes the delayed association of PMR1 with SGs under conditions which cause tristetraprolin and butyrate response factor 1, proteins that facilitate exonucleolytic mRNA, to exit SGs.	arsenite	22-30	ZFP36 ring finger protein	Homo sapiens	110-125
16982678-7	2006	Finally, we show that arsenite promotes the delayed association of PMR1 with SGs under conditions which cause tristetraprolin and butyrate response factor 1, proteins that facilitate exonucleolytic mRNA, to exit SGs.	arsenite	22-30	ZFP36 ring finger protein like 1	Homo sapiens	130-156
17005224-6	2006	Real-time PCR analysis of cyclin D1 transcription showed that there was an induction of more than three-fold in cells exposed to 400 nM arsenite for 3 days.	arsenite	136-144	cyclin D1	Homo sapiens	26-35
17005224-8	2006	Electrophoretic mobility shift assays (EMSA) showed that arsenite also stimulated binding of the transcription factors, AP1 and CREBP to their respective binding motifs within 3 days.	arsenite	57-65	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	120-123
16973625-0	2006	Coordination of JNK1 and JNK2 is critical for GADD45alpha induction and its mediated cell apoptosis in arsenite responses.	arsenite	103-111	mitogen-activated protein kinase 8	Mus musculus	16-20
17116751-0	2006	IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response.	arsenite	105-113	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	0-7
17116751-0	2006	IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response.	arsenite	105-113	growth arrest and DNA damage inducible alpha	Homo sapiens	32-43
17116751-0	2006	IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response.	arsenite	105-113	mitogen-activated protein kinase kinase 4	Homo sapiens	44-48
17116751-0	2006	IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response.	arsenite	105-113	mitogen-activated protein kinase 8	Homo sapiens	49-52
17116751-0	2006	IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response.	arsenite	105-113	nuclear factor kappa B subunit 1	Homo sapiens	88-91
17116751-0	2006	IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response.	arsenite	105-113	nuclear factor kappa B subunit 1	Homo sapiens	92-101
17116751-3	2006	We provide a novel scenario of the proapoptotic role of IkappaB kinase beta (IKKbeta)-NF-kappaB, which can act as the activator of the JNK pathway through the induction of GADD45alpha for triggering MKK4/JNK activation, in response to the stimulation of arsenite, a cancer therapeutic reagent.	arsenite	254-262	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	56-75
17116751-3	2006	We provide a novel scenario of the proapoptotic role of IkappaB kinase beta (IKKbeta)-NF-kappaB, which can act as the activator of the JNK pathway through the induction of GADD45alpha for triggering MKK4/JNK activation, in response to the stimulation of arsenite, a cancer therapeutic reagent.	arsenite	254-262	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	77-84
17116751-3	2006	We provide a novel scenario of the proapoptotic role of IkappaB kinase beta (IKKbeta)-NF-kappaB, which can act as the activator of the JNK pathway through the induction of GADD45alpha for triggering MKK4/JNK activation, in response to the stimulation of arsenite, a cancer therapeutic reagent.	arsenite	254-262	nuclear factor kappa B subunit 1	Homo sapiens	86-95
17116751-3	2006	We provide a novel scenario of the proapoptotic role of IkappaB kinase beta (IKKbeta)-NF-kappaB, which can act as the activator of the JNK pathway through the induction of GADD45alpha for triggering MKK4/JNK activation, in response to the stimulation of arsenite, a cancer therapeutic reagent.	arsenite	254-262	mitogen-activated protein kinase 8	Homo sapiens	135-138
17116751-3	2006	We provide a novel scenario of the proapoptotic role of IkappaB kinase beta (IKKbeta)-NF-kappaB, which can act as the activator of the JNK pathway through the induction of GADD45alpha for triggering MKK4/JNK activation, in response to the stimulation of arsenite, a cancer therapeutic reagent.	arsenite	254-262	growth arrest and DNA damage inducible alpha	Homo sapiens	172-183
17116751-3	2006	We provide a novel scenario of the proapoptotic role of IkappaB kinase beta (IKKbeta)-NF-kappaB, which can act as the activator of the JNK pathway through the induction of GADD45alpha for triggering MKK4/JNK activation, in response to the stimulation of arsenite, a cancer therapeutic reagent.	arsenite	254-262	mitogen-activated protein kinase kinase 4	Homo sapiens	199-203
17116751-3	2006	We provide a novel scenario of the proapoptotic role of IkappaB kinase beta (IKKbeta)-NF-kappaB, which can act as the activator of the JNK pathway through the induction of GADD45alpha for triggering MKK4/JNK activation, in response to the stimulation of arsenite, a cancer therapeutic reagent.	arsenite	254-262	mitogen-activated protein kinase 8	Homo sapiens	204-207
16973625-0	2006	Coordination of JNK1 and JNK2 is critical for GADD45alpha induction and its mediated cell apoptosis in arsenite responses.	arsenite	103-111	mitogen-activated protein kinase 9	Mus musculus	25-29
16973625-0	2006	Coordination of JNK1 and JNK2 is critical for GADD45alpha induction and its mediated cell apoptosis in arsenite responses.	arsenite	103-111	growth arrest and DNA-damage-inducible 45 alpha	Mus musculus	46-57
16973625-5	2006	The present study further revealed that the coordination of JNK1 and JNK2 was critical for the arsenite-induced expression of GADD45alpha (growth arrest and DNA damage 45alpha), which in turn mediated the cellular apoptosis.	arsenite	95-103	mitogen-activated protein kinase 8	Mus musculus	60-64
16973625-5	2006	The present study further revealed that the coordination of JNK1 and JNK2 was critical for the arsenite-induced expression of GADD45alpha (growth arrest and DNA damage 45alpha), which in turn mediated the cellular apoptosis.	arsenite	95-103	mitogen-activated protein kinase 9	Mus musculus	69-73
16973625-5	2006	The present study further revealed that the coordination of JNK1 and JNK2 was critical for the arsenite-induced expression of GADD45alpha (growth arrest and DNA damage 45alpha), which in turn mediated the cellular apoptosis.	arsenite	95-103	growth arrest and DNA-damage-inducible 45 alpha	Mus musculus	126-137
16973625-6	2006	The arsenite-induced apoptosis and GADD45alpha expression were significantly impaired in mouse embryonic fibroblasts deficient in either jnk1 (JNK1-/-) or jnk2 (JNK2-/-).	arsenite	4-12	growth arrest and DNA-damage-inducible 45 alpha	Mus musculus	35-46
16973625-6	2006	The arsenite-induced apoptosis and GADD45alpha expression were significantly impaired in mouse embryonic fibroblasts deficient in either jnk1 (JNK1-/-) or jnk2 (JNK2-/-).	arsenite	4-12	mitogen-activated protein kinase 8	Mus musculus	137-141
16973625-6	2006	The arsenite-induced apoptosis and GADD45alpha expression were significantly impaired in mouse embryonic fibroblasts deficient in either jnk1 (JNK1-/-) or jnk2 (JNK2-/-).	arsenite	4-12	mitogen-activated protein kinase 8	Mus musculus	143-147
16973625-6	2006	The arsenite-induced apoptosis and GADD45alpha expression were significantly impaired in mouse embryonic fibroblasts deficient in either jnk1 (JNK1-/-) or jnk2 (JNK2-/-).	arsenite	4-12	mitogen-activated protein kinase 9	Mus musculus	155-159
16973625-6	2006	The arsenite-induced apoptosis and GADD45alpha expression were significantly impaired in mouse embryonic fibroblasts deficient in either jnk1 (JNK1-/-) or jnk2 (JNK2-/-).	arsenite	4-12	mitogen-activated protein kinase 9	Mus musculus	161-165
16973625-9	2006	Our results demonstrate that the coordination of JNK1 and JNK2 is critical for c-Jun/GADD45alpha-mediated cellular apoptosis induced by arsenite.	arsenite	136-144	mitogen-activated protein kinase 8	Mus musculus	49-53
16973625-9	2006	Our results demonstrate that the coordination of JNK1 and JNK2 is critical for c-Jun/GADD45alpha-mediated cellular apoptosis induced by arsenite.	arsenite	136-144	mitogen-activated protein kinase 9	Mus musculus	58-62
16973625-9	2006	Our results demonstrate that the coordination of JNK1 and JNK2 is critical for c-Jun/GADD45alpha-mediated cellular apoptosis induced by arsenite.	arsenite	136-144	jun proto-oncogene	Mus musculus	79-84
16973625-9	2006	Our results demonstrate that the coordination of JNK1 and JNK2 is critical for c-Jun/GADD45alpha-mediated cellular apoptosis induced by arsenite.	arsenite	136-144	growth arrest and DNA-damage-inducible 45 alpha	Mus musculus	85-96
16739126-7	2006	These data suggest that the direct inhibition of p53 functional activation is one of the mechanisms through which arsenite interferes with p53 function, and thus may be a significant mechanism for the co-carcinogenic effects of arsenite.	arsenite	228-236	transformation related protein 53, pseudogene	Mus musculus	139-142
17038550-2	2006	Arsenite strongly induced p38 MAPK phosphorylation in isolated rat cardiac myocytes but also moderately enhanced phosphorylation of p42/44 ERK and p70 S6K.	arsenite	0-8	Eph receptor B1	Rattus norvegicus	139-142
17038550-2	2006	Arsenite strongly induced p38 MAPK phosphorylation in isolated rat cardiac myocytes but also moderately enhanced phosphorylation of p42/44 ERK and p70 S6K.	arsenite	0-8	ribosomal protein S6 kinase B1	Rattus norvegicus	147-154
16739126-0	2006	Arsenite inhibits p53 phosphorylation, DNA binding activity, and p53 target gene p21 expression in mouse epidermal JB6 cells.	arsenite	0-8	transformation related protein 53, pseudogene	Mus musculus	18-21
16739126-0	2006	Arsenite inhibits p53 phosphorylation, DNA binding activity, and p53 target gene p21 expression in mouse epidermal JB6 cells.	arsenite	0-8	transformation related protein 53, pseudogene	Mus musculus	65-68
17030823-7	2006	Interaction with ArsD increases the affinity of ArsA for arsenite, thus increasing its ATPase activity at lower concentrations of arsenite and enhancing the rate of arsenite extrusion.	arsenite	57-65	ArsD	Escherichia coli	17-21
16739126-0	2006	Arsenite inhibits p53 phosphorylation, DNA binding activity, and p53 target gene p21 expression in mouse epidermal JB6 cells.	arsenite	0-8	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	81-84
16739126-3	2006	Arsenite may function as a co-carcinogen, acting by inhibiting repair of carcinogen-induced DNA damage mediated by p53 and p21, a p53 target gene.	arsenite	0-8	transformation related protein 53, pseudogene	Mus musculus	115-118
16739126-3	2006	Arsenite may function as a co-carcinogen, acting by inhibiting repair of carcinogen-induced DNA damage mediated by p53 and p21, a p53 target gene.	arsenite	0-8	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	123-126
16739126-3	2006	Arsenite may function as a co-carcinogen, acting by inhibiting repair of carcinogen-induced DNA damage mediated by p53 and p21, a p53 target gene.	arsenite	0-8	transformation related protein 53, pseudogene	Mus musculus	130-133
16739126-5	2006	Our results indicated that arsenite suppressed UVB-induced p53 phosphorylation and p53 DNA binding activity.	arsenite	27-35	transformation related protein 53, pseudogene	Mus musculus	59-62
16739126-5	2006	Our results indicated that arsenite suppressed UVB-induced p53 phosphorylation and p53 DNA binding activity.	arsenite	27-35	transformation related protein 53, pseudogene	Mus musculus	83-86
16739126-6	2006	Arsenite also inhibited casein kinase 2 (CK2) activity and decreased p53-regulated p21 protein expression.	arsenite	0-8	casein kinase 2, alpha prime polypeptide	Mus musculus	24-39
16739126-6	2006	Arsenite also inhibited casein kinase 2 (CK2) activity and decreased p53-regulated p21 protein expression.	arsenite	0-8	casein kinase 2, alpha prime polypeptide	Mus musculus	41-44
16739126-6	2006	Arsenite also inhibited casein kinase 2 (CK2) activity and decreased p53-regulated p21 protein expression.	arsenite	0-8	transformation related protein 53, pseudogene	Mus musculus	69-72
16739126-6	2006	Arsenite also inhibited casein kinase 2 (CK2) activity and decreased p53-regulated p21 protein expression.	arsenite	0-8	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	83-86
16739126-7	2006	These data suggest that the direct inhibition of p53 functional activation is one of the mechanisms through which arsenite interferes with p53 function, and thus may be a significant mechanism for the co-carcinogenic effects of arsenite.	arsenite	114-122	transformation related protein 53, pseudogene	Mus musculus	49-52
16739126-7	2006	These data suggest that the direct inhibition of p53 functional activation is one of the mechanisms through which arsenite interferes with p53 function, and thus may be a significant mechanism for the co-carcinogenic effects of arsenite.	arsenite	114-122	transformation related protein 53, pseudogene	Mus musculus	139-142
16739126-7	2006	These data suggest that the direct inhibition of p53 functional activation is one of the mechanisms through which arsenite interferes with p53 function, and thus may be a significant mechanism for the co-carcinogenic effects of arsenite.	arsenite	228-236	transformation related protein 53, pseudogene	Mus musculus	49-52
17290776-3	2006	Experiments with p53 + / - and K6/ODC transgenic mice administered dimethylarsinic acid (DMA) or arsenite have shown some degree of carcinogenic, cocarcinogenic, or promotional activity in skin or bladder.	arsenite	97-105	keratin 6	Mus musculus	31-37
17030823-7	2006	Interaction with ArsD increases the affinity of ArsA for arsenite, thus increasing its ATPase activity at lower concentrations of arsenite and enhancing the rate of arsenite extrusion.	arsenite	57-65	ATPase	Escherichia coli	87-93
17030823-7	2006	Interaction with ArsD increases the affinity of ArsA for arsenite, thus increasing its ATPase activity at lower concentrations of arsenite and enhancing the rate of arsenite extrusion.	arsenite	130-138	ArsD	Escherichia coli	17-21
17030823-7	2006	Interaction with ArsD increases the affinity of ArsA for arsenite, thus increasing its ATPase activity at lower concentrations of arsenite and enhancing the rate of arsenite extrusion.	arsenite	130-138	ATPase	Escherichia coli	87-93
17030823-7	2006	Interaction with ArsD increases the affinity of ArsA for arsenite, thus increasing its ATPase activity at lower concentrations of arsenite and enhancing the rate of arsenite extrusion.	arsenite	130-138	ArsD	Escherichia coli	17-21
17030823-7	2006	Interaction with ArsD increases the affinity of ArsA for arsenite, thus increasing its ATPase activity at lower concentrations of arsenite and enhancing the rate of arsenite extrusion.	arsenite	130-138	ATPase	Escherichia coli	87-93
16887808-8	2006	For example arsenite, which inhibits 5"-cap-dependent translational initiation, shifted mRNA-A3G-PABP from polysomes into stress granules in a manner that was blocked and reversed by the elongation inhibitor cycloheximide.	arsenite	12-20	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	93-96
17079871-2	2006	Cys-179 in the activation loop of IKKbeta is known to be the target site for IKK inhibitors such as cyclopentenone prostaglandins, arsenite, and antirheumatic gold compounds.	arsenite	131-139	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	34-41
17079871-2	2006	Cys-179 in the activation loop of IKKbeta is known to be the target site for IKK inhibitors such as cyclopentenone prostaglandins, arsenite, and antirheumatic gold compounds.	arsenite	131-139	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	34-37
16927016-6	2006	Arsenite, a direct stimulator of p38 MAPK, also led to an increased PPARgamma expression, thereby mimicking the effects of butyrate.	arsenite	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	68-77
16920868-0	2006	Mitogen-activated protein kinase Hog1 is essential for the response to arsenite in Saccharomyces cerevisiae.	arsenite	71-79	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	33-37
16920868-1	2006	Here we describe, for the first time, that budding yeast mitogen-activated protein kinase Hog1 and its upstream activators Pbs2 and Ssk1 are essential for the response to arsenite.	arsenite	171-179	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	90-94
16920868-1	2006	Here we describe, for the first time, that budding yeast mitogen-activated protein kinase Hog1 and its upstream activators Pbs2 and Ssk1 are essential for the response to arsenite.	arsenite	171-179	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	123-127
16920868-1	2006	Here we describe, for the first time, that budding yeast mitogen-activated protein kinase Hog1 and its upstream activators Pbs2 and Ssk1 are essential for the response to arsenite.	arsenite	171-179	mitogen-activated protein kinase kinase kinase SSK1	Saccharomyces cerevisiae S288C	132-136
16920868-2	2006	Hog1 is rapidly phosphorylated in response to arsenite and triggers a transcriptional response that involves the upregulation of genes essential for arsenite detoxification.	arsenite	46-54	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	0-4
16920868-2	2006	Hog1 is rapidly phosphorylated in response to arsenite and triggers a transcriptional response that involves the upregulation of genes essential for arsenite detoxification.	arsenite	149-157	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	0-4
16959797-6	2006	511, 21-27], and then examined the effect of DCFH-DA on the induction of HO-1 expression by arsenite, cadmium and hemin, which induce oxidative stress and cytotoxicity.	arsenite	92-100	heme oxygenase 1	Homo sapiens	73-77
16959797-7	2006	We found suppression of the arsenite-, cadmium- and hemin-dependent induction of HO-1 with DCFH-DA.	arsenite	28-36	heme oxygenase 1	Homo sapiens	81-85
16885417-0	2006	The MAPK Hog1p modulates Fps1p-dependent arsenite uptake and tolerance in yeast.	arsenite	41-49	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	9-14
16885417-0	2006	The MAPK Hog1p modulates Fps1p-dependent arsenite uptake and tolerance in yeast.	arsenite	41-49	Fps1p	Saccharomyces cerevisiae S288C	25-30
16885417-3	2006	Here, we describe a novel role of the S. cerevisiae mitogen-activated protein kinase Hog1p in protecting cells during exposure to arsenite and the related metalloid antimonite.	arsenite	130-138	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	85-90
16885417-5	2006	Hog1p is phosphorylated in response to arsenite and this phosphorylation requires Ssk1p and Pbs2p.	arsenite	39-47	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	0-5
16885417-5	2006	Hog1p is phosphorylated in response to arsenite and this phosphorylation requires Ssk1p and Pbs2p.	arsenite	39-47	mitogen-activated protein kinase kinase kinase SSK1	Saccharomyces cerevisiae S288C	82-87
16885417-5	2006	Hog1p is phosphorylated in response to arsenite and this phosphorylation requires Ssk1p and Pbs2p.	arsenite	39-47	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	92-97
16885417-7	2006	Instead, hog1delta sensitivity is accompanied by elevated cellular arsenic levels and we demonstrate that increased arsenite influx is dependent on the aquaglyceroporin Fps1p.	arsenite	116-124	Fps1p	Saccharomyces cerevisiae S288C	169-174
16887808-8	2006	For example arsenite, which inhibits 5"-cap-dependent translational initiation, shifted mRNA-A3G-PABP from polysomes into stress granules in a manner that was blocked and reversed by the elongation inhibitor cycloheximide.	arsenite	12-20	poly(A) binding protein cytoplasmic 1	Homo sapiens	97-101
16973439-1	2006	Protein misfolding caused by exposure to arsenite is associated with transcriptional activation of the AIRAP gene.	arsenite	41-49	zinc finger, AN1-type domain 2A	Mus musculus	103-108
16840785-5	2006	Similarly, green fluorescent protein-tagged Hsp25 shows retarded subcellular accumulation into stress granules in MK2-deficient cells after arsenite treatment.	arsenite	140-148	heat shock protein family B (small) member 1	Homo sapiens	44-49
16840785-5	2006	Similarly, green fluorescent protein-tagged Hsp25 shows retarded subcellular accumulation into stress granules in MK2-deficient cells after arsenite treatment.	arsenite	140-148	MAPK activated protein kinase 2	Homo sapiens	114-117
16840785-6	2006	Decreased insolubilization of Hsp25 in MK2-deficient cells correlates with increased resistance against arsenite, H2O2, and sublethal heat shock treatment and with decreased apoptosis.	arsenite	104-112	heat shock protein family B (small) member 1	Homo sapiens	30-35
16840785-6	2006	Decreased insolubilization of Hsp25 in MK2-deficient cells correlates with increased resistance against arsenite, H2O2, and sublethal heat shock treatment and with decreased apoptosis.	arsenite	104-112	MAPK activated protein kinase 2	Homo sapiens	39-42
16973439-2	2006	We report here that AIRAP is an arsenite-inducible subunit of the proteasome"s 19S cap that binds near PSMD2 at the 19S base.	arsenite	32-40	zinc finger, AN1-type domain 2A	Mus musculus	20-25
16973439-2	2006	We report here that AIRAP is an arsenite-inducible subunit of the proteasome"s 19S cap that binds near PSMD2 at the 19S base.	arsenite	32-40	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	Mus musculus	103-108
16973439-3	2006	Compared to the wild-type, knockout mouse cells or C. elegans lacking AIRAP accumulate more polyubiquitylated proteins and exhibit higher levels of stress when exposed to arsenite, and proteasomes isolated from arsenite-treated AIRAP knockout cells are relatively impaired in substrate degradation in vitro.	arsenite	171-179	zinc finger, AN1-type domain 2A	Mus musculus	70-75
16973439-3	2006	Compared to the wild-type, knockout mouse cells or C. elegans lacking AIRAP accumulate more polyubiquitylated proteins and exhibit higher levels of stress when exposed to arsenite, and proteasomes isolated from arsenite-treated AIRAP knockout cells are relatively impaired in substrate degradation in vitro.	arsenite	211-219	zinc finger, AN1-type domain 2A	Mus musculus	228-233
16809336-6	2006	Site-directed mutation of two putative NFAT binding sites between-111 to +65 in the COX-2 promoter region eliminated the COX-2 transcriptional activity induced by arsenite, confirming that those two NFAT binding sites in the COX-2 promoter region are critical for COX-2 induction by arsenite.	arsenite	163-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
16797887-0	2006	Arsenite induces apoptosis in hepatocytes through an enhancement of the activation of Jun N-terminal kinase and p38 mitogen-activated protein kinase caused by partial hepatectomy.	arsenite	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	86-107
16797887-0	2006	Arsenite induces apoptosis in hepatocytes through an enhancement of the activation of Jun N-terminal kinase and p38 mitogen-activated protein kinase caused by partial hepatectomy.	arsenite	0-8	mitogen activated protein kinase 14	Rattus norvegicus	112-148
16797887-3	2006	The effect of the arsenite-injection on the activation of extracellular signal-regulated kinase (ERK) was not observed in the normal or the partially hepatectomized liver.	arsenite	18-26	Eph receptor B1	Rattus norvegicus	58-95
16797887-3	2006	The effect of the arsenite-injection on the activation of extracellular signal-regulated kinase (ERK) was not observed in the normal or the partially hepatectomized liver.	arsenite	18-26	Eph receptor B1	Rattus norvegicus	97-100
16797887-4	2006	The activity of p38 mitogen-activated protein kinase (MAPK) markedly increased after 15min to 2h after the arsenite-injection in partially hepatectomized liver while no or a less increase was observed in the arsenite-injected normal or the control, respectively.	arsenite	107-115	mitogen activated protein kinase 14	Rattus norvegicus	16-52
16797887-6	2006	The arsenite-injection markedly increased the phosphorylated forms of c-Jun and ATF-2 and the protein levels of c-Jun, p53 and p21(WAF1/CIP1) in the partially hepatectomized liver.	arsenite	4-12	activating transcription factor 2	Rattus norvegicus	80-85
16797887-6	2006	The arsenite-injection markedly increased the phosphorylated forms of c-Jun and ATF-2 and the protein levels of c-Jun, p53 and p21(WAF1/CIP1) in the partially hepatectomized liver.	arsenite	4-12	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	119-122
16809336-0	2006	Cyclooxygenase-2 induction by arsenite is through a nuclear factor of activated T-cell-dependent pathway and plays an antiapoptotic role in Beas-2B cells.	arsenite	30-38	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-16
16809336-3	2006	The current study demonstrated that exposure of human bronchial epithelial cells (Beas-2B) to arsenite resulted in a marked induction of cyclooxygenase (COX)-2, an important mediator for inflammation and tumor promotion.	arsenite	94-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-159
16809336-4	2006	Exposure of the Beas-2B cells to arsenite also led to significant transactivation of nuclear factor of activated T-cells (NFAT), but not activator protein-1 (AP-1) and NFkappaB, suggesting that NFAT, rather than AP-1 or NFkappaB, is implicated in the responses of Beas-2B cells to arsenite exposure.	arsenite	33-41	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	137-156
16809336-4	2006	Exposure of the Beas-2B cells to arsenite also led to significant transactivation of nuclear factor of activated T-cells (NFAT), but not activator protein-1 (AP-1) and NFkappaB, suggesting that NFAT, rather than AP-1 or NFkappaB, is implicated in the responses of Beas-2B cells to arsenite exposure.	arsenite	33-41	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	212-216
16809336-4	2006	Exposure of the Beas-2B cells to arsenite also led to significant transactivation of nuclear factor of activated T-cells (NFAT), but not activator protein-1 (AP-1) and NFkappaB, suggesting that NFAT, rather than AP-1 or NFkappaB, is implicated in the responses of Beas-2B cells to arsenite exposure.	arsenite	33-41	nuclear factor kappa B subunit 1	Homo sapiens	220-228
16809336-5	2006	Furthermore, we found that inhibition of the NFAT pathway by either chemical inhibitors, dominant negative mutants of NFAT, or NFAT3 small interference RNA resulted in the impairment of COX-2 induction and caused cell apoptosis in Beas-2B cells exposed to arsenite.	arsenite	256-264	nuclear factor of activated T cells 4	Homo sapiens	127-132
16797887-6	2006	The arsenite-injection markedly increased the phosphorylated forms of c-Jun and ATF-2 and the protein levels of c-Jun, p53 and p21(WAF1/CIP1) in the partially hepatectomized liver.	arsenite	4-12	KRAS proto-oncogene, GTPase	Rattus norvegicus	127-130
16797887-6	2006	The arsenite-injection markedly increased the phosphorylated forms of c-Jun and ATF-2 and the protein levels of c-Jun, p53 and p21(WAF1/CIP1) in the partially hepatectomized liver.	arsenite	4-12	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	131-135
16797887-6	2006	The arsenite-injection markedly increased the phosphorylated forms of c-Jun and ATF-2 and the protein levels of c-Jun, p53 and p21(WAF1/CIP1) in the partially hepatectomized liver.	arsenite	4-12	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	136-140
16797887-7	2006	These results suggested that arsenite induced apoptosis in the hepatocytes in vivo, through the enhancement of the activation of JNK and p38 MAPK caused by partial hepatectomy and the p53-dependent p21(WAF1/CIP1) protein expression.	arsenite	29-37	mitogen-activated protein kinase 8	Rattus norvegicus	129-132
16797887-7	2006	These results suggested that arsenite induced apoptosis in the hepatocytes in vivo, through the enhancement of the activation of JNK and p38 MAPK caused by partial hepatectomy and the p53-dependent p21(WAF1/CIP1) protein expression.	arsenite	29-37	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	184-187
16797887-7	2006	These results suggested that arsenite induced apoptosis in the hepatocytes in vivo, through the enhancement of the activation of JNK and p38 MAPK caused by partial hepatectomy and the p53-dependent p21(WAF1/CIP1) protein expression.	arsenite	29-37	KRAS proto-oncogene, GTPase	Rattus norvegicus	198-201
16797887-7	2006	These results suggested that arsenite induced apoptosis in the hepatocytes in vivo, through the enhancement of the activation of JNK and p38 MAPK caused by partial hepatectomy and the p53-dependent p21(WAF1/CIP1) protein expression.	arsenite	29-37	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	202-211
16966095-0	2006	Exit from arsenite-induced mitotic arrest is p53 dependent.	arsenite	10-18	tumor protein p53	Homo sapiens	45-48
16966095-2	2006	Using a model cell line in which p53 expression is regulated exogenously in a tetracycline-off system (TR9-7 cells) , our laboratory has shown that arsenite disrupts mitosis and that p53-deficient cells [p53(-)], in contrast to p53-expressing cells [p53(+)], display greater sensitivity to arsenite-induced mitotic arrest and apoptosis.	arsenite	148-156	tumor protein p53	Homo sapiens	33-36
16966095-3	2006	OBJECTIVE: Our goal was to examine the role p53 plays in protecting cells from arsenite-induced mitotic arrest.	arsenite	79-87	tumor protein p53	Homo sapiens	44-47
16966095-5	2006	RESULTS: Mitotic index analysis demonstrated that arsenite treatment delayed exit from G2 in p53(+) and p53(-) cells.	arsenite	50-58	tumor protein p53	Homo sapiens	93-96
16966095-5	2006	RESULTS: Mitotic index analysis demonstrated that arsenite treatment delayed exit from G2 in p53(+) and p53(-) cells.	arsenite	50-58	tumor protein p53	Homo sapiens	104-107
16966095-6	2006	Arsenite-treated p53(+) cells exited mitosis normally, whereas p53(-) cells exited mitosis with delayed kinetics.	arsenite	0-8	tumor protein p53	Homo sapiens	17-20
16966095-7	2006	Microarray analysis performed on mRNAs of cells exposed to arsenite for 0 and 3 hr after release from G2 phase synchrony showed that arsenite induced inhibitor of DNA binding-1 (ID1) differentially in p53(+) and p53(-) cells.	arsenite	59-67	inhibitor of DNA binding 1, HLH protein	Homo sapiens	150-176
16966095-7	2006	Microarray analysis performed on mRNAs of cells exposed to arsenite for 0 and 3 hr after release from G2 phase synchrony showed that arsenite induced inhibitor of DNA binding-1 (ID1) differentially in p53(+) and p53(-) cells.	arsenite	59-67	inhibitor of DNA binding 1, HLH protein	Homo sapiens	178-181
16966095-7	2006	Microarray analysis performed on mRNAs of cells exposed to arsenite for 0 and 3 hr after release from G2 phase synchrony showed that arsenite induced inhibitor of DNA binding-1 (ID1) differentially in p53(+) and p53(-) cells.	arsenite	59-67	tumor protein p53	Homo sapiens	201-204
16966095-7	2006	Microarray analysis performed on mRNAs of cells exposed to arsenite for 0 and 3 hr after release from G2 phase synchrony showed that arsenite induced inhibitor of DNA binding-1 (ID1) differentially in p53(+) and p53(-) cells.	arsenite	59-67	tumor protein p53	Homo sapiens	212-215
16966095-7	2006	Microarray analysis performed on mRNAs of cells exposed to arsenite for 0 and 3 hr after release from G2 phase synchrony showed that arsenite induced inhibitor of DNA binding-1 (ID1) differentially in p53(+) and p53(-) cells.	arsenite	133-141	inhibitor of DNA binding 1, HLH protein	Homo sapiens	150-176
16966095-7	2006	Microarray analysis performed on mRNAs of cells exposed to arsenite for 0 and 3 hr after release from G2 phase synchrony showed that arsenite induced inhibitor of DNA binding-1 (ID1) differentially in p53(+) and p53(-) cells.	arsenite	133-141	inhibitor of DNA binding 1, HLH protein	Homo sapiens	178-181
16966095-7	2006	Microarray analysis performed on mRNAs of cells exposed to arsenite for 0 and 3 hr after release from G2 phase synchrony showed that arsenite induced inhibitor of DNA binding-1 (ID1) differentially in p53(+) and p53(-) cells.	arsenite	133-141	tumor protein p53	Homo sapiens	201-204
16966095-7	2006	Microarray analysis performed on mRNAs of cells exposed to arsenite for 0 and 3 hr after release from G2 phase synchrony showed that arsenite induced inhibitor of DNA binding-1 (ID1) differentially in p53(+) and p53(-) cells.	arsenite	133-141	tumor protein p53	Homo sapiens	212-215
16966095-9	2006	CONCLUSIONS: p53 promotes mitotic exit and leads to more extensive ID1 induction by arsenite.	arsenite	84-92	tumor protein p53	Homo sapiens	13-16
16966095-9	2006	CONCLUSIONS: p53 promotes mitotic exit and leads to more extensive ID1 induction by arsenite.	arsenite	84-92	inhibitor of DNA binding 1, HLH protein	Homo sapiens	67-70
16966095-11	2006	ID1 may play a role in the survival of arsenite-treated p53(+) cells and contribute to arsenic carcinogenicity.	arsenite	39-47	inhibitor of DNA binding 1, HLH protein	Homo sapiens	0-3
16966095-11	2006	ID1 may play a role in the survival of arsenite-treated p53(+) cells and contribute to arsenic carcinogenicity.	arsenite	39-47	tumor protein p53	Homo sapiens	56-59
16809336-6	2006	Site-directed mutation of two putative NFAT binding sites between-111 to +65 in the COX-2 promoter region eliminated the COX-2 transcriptional activity induced by arsenite, confirming that those two NFAT binding sites in the COX-2 promoter region are critical for COX-2 induction by arsenite.	arsenite	163-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
16809336-6	2006	Site-directed mutation of two putative NFAT binding sites between-111 to +65 in the COX-2 promoter region eliminated the COX-2 transcriptional activity induced by arsenite, confirming that those two NFAT binding sites in the COX-2 promoter region are critical for COX-2 induction by arsenite.	arsenite	163-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
16809336-6	2006	Site-directed mutation of two putative NFAT binding sites between-111 to +65 in the COX-2 promoter region eliminated the COX-2 transcriptional activity induced by arsenite, confirming that those two NFAT binding sites in the COX-2 promoter region are critical for COX-2 induction by arsenite.	arsenite	163-171	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
16809336-6	2006	Site-directed mutation of two putative NFAT binding sites between-111 to +65 in the COX-2 promoter region eliminated the COX-2 transcriptional activity induced by arsenite, confirming that those two NFAT binding sites in the COX-2 promoter region are critical for COX-2 induction by arsenite.	arsenite	283-291	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
16809336-6	2006	Site-directed mutation of two putative NFAT binding sites between-111 to +65 in the COX-2 promoter region eliminated the COX-2 transcriptional activity induced by arsenite, confirming that those two NFAT binding sites in the COX-2 promoter region are critical for COX-2 induction by arsenite.	arsenite	283-291	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
16809336-6	2006	Site-directed mutation of two putative NFAT binding sites between-111 to +65 in the COX-2 promoter region eliminated the COX-2 transcriptional activity induced by arsenite, confirming that those two NFAT binding sites in the COX-2 promoter region are critical for COX-2 induction by arsenite.	arsenite	283-291	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
16809336-6	2006	Site-directed mutation of two putative NFAT binding sites between-111 to +65 in the COX-2 promoter region eliminated the COX-2 transcriptional activity induced by arsenite, confirming that those two NFAT binding sites in the COX-2 promoter region are critical for COX-2 induction by arsenite.	arsenite	283-291	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126
16809336-7	2006	Moreover, knockdown of COX-2 expression by COX-2-specific small interference RNA also led to an increased cell apoptosis in Beas-2B cells upon arsenite exposure.	arsenite	143-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	23-28
16809336-7	2006	Moreover, knockdown of COX-2 expression by COX-2-specific small interference RNA also led to an increased cell apoptosis in Beas-2B cells upon arsenite exposure.	arsenite	143-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
16809336-8	2006	Together, our results demonstrate that COX-2 induction by arsenite is through NFAT3-dependent and AP-1- or NFkappaB-independent pathways and plays a crucial role in antagonizing arsenite-induced cell apoptosis in human bronchial epithelial Beas-2B cells.	arsenite	58-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
16809336-8	2006	Together, our results demonstrate that COX-2 induction by arsenite is through NFAT3-dependent and AP-1- or NFkappaB-independent pathways and plays a crucial role in antagonizing arsenite-induced cell apoptosis in human bronchial epithelial Beas-2B cells.	arsenite	58-66	nuclear factor of activated T cells 4	Homo sapiens	78-83
16809336-8	2006	Together, our results demonstrate that COX-2 induction by arsenite is through NFAT3-dependent and AP-1- or NFkappaB-independent pathways and plays a crucial role in antagonizing arsenite-induced cell apoptosis in human bronchial epithelial Beas-2B cells.	arsenite	58-66	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	98-102
16809336-8	2006	Together, our results demonstrate that COX-2 induction by arsenite is through NFAT3-dependent and AP-1- or NFkappaB-independent pathways and plays a crucial role in antagonizing arsenite-induced cell apoptosis in human bronchial epithelial Beas-2B cells.	arsenite	58-66	nuclear factor kappa B subunit 1	Homo sapiens	107-115
16809336-8	2006	Together, our results demonstrate that COX-2 induction by arsenite is through NFAT3-dependent and AP-1- or NFkappaB-independent pathways and plays a crucial role in antagonizing arsenite-induced cell apoptosis in human bronchial epithelial Beas-2B cells.	arsenite	178-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44
16479312-7	2006	Rifampin and taurocholic acid (a substrate of OATP-C) reversed the increased toxicity of arsenate and arsenite seen in OATP-C-transfected cells.	arsenite	102-110	solute carrier organic anion transporter family member 1B1	Homo sapiens	46-52
16494910-0	2006	Arsenite pretreatment enhances the cytotoxicity of mitomycin C in human cancer cell lines via increased NAD(P)H quinone oxidoreductase 1 expression.	arsenite	0-8	NAD(P)H quinone dehydrogenase 1	Homo sapiens	104-136
16494910-3	2006	Here, we report that arsenite-resistant human lung cancer CL3R15 cells constitutively overexpress NAD(P)H quinone oxidoreductase 1 (NQO1), an enzyme responsible for activation of mitomycin C (MMC), and are more susceptible to MMC cytotoxicity than parental CL3 cells.	arsenite	21-29	NAD(P)H dehydrogenase, quinone 1	Mus musculus	98-130
16494910-3	2006	Here, we report that arsenite-resistant human lung cancer CL3R15 cells constitutively overexpress NAD(P)H quinone oxidoreductase 1 (NQO1), an enzyme responsible for activation of mitomycin C (MMC), and are more susceptible to MMC cytotoxicity than parental CL3 cells.	arsenite	21-29	NAD(P)H dehydrogenase, quinone 1	Mus musculus	132-136
16494910-4	2006	The effects of arsenite pretreatment on NQO1 induction were examined in CL3, H1299, H460, and MC-T2 cells.	arsenite	15-23	NAD(P)H dehydrogenase, quinone 1	Mus musculus	40-44
16494910-5	2006	Arsenite pretreatment significantly enhanced the expression of NQO1 and susceptibility to MMC in CL3, H1299, and MC-T2 cells, but not in H460 cells that express high endogenous levels of NQO1.	arsenite	0-8	NAD(P)H dehydrogenase, quinone 1	Mus musculus	63-67
16494910-5	2006	Arsenite pretreatment significantly enhanced the expression of NQO1 and susceptibility to MMC in CL3, H1299, and MC-T2 cells, but not in H460 cells that express high endogenous levels of NQO1.	arsenite	0-8	NAD(P)H quinone dehydrogenase 1	Homo sapiens	187-191
16494910-7	2006	Arsenite-mediated MMC susceptibility was abrogated by dicumarol (DIC), an NQO1 inhibitor, indicating that NQO1 is one of the key regulators of arsenite-mediated MMC susceptibility.	arsenite	0-8	NAD(P)H quinone dehydrogenase 1	Homo sapiens	74-78
16494910-7	2006	Arsenite-mediated MMC susceptibility was abrogated by dicumarol (DIC), an NQO1 inhibitor, indicating that NQO1 is one of the key regulators of arsenite-mediated MMC susceptibility.	arsenite	0-8	NAD(P)H quinone dehydrogenase 1	Homo sapiens	106-110
16494910-7	2006	Arsenite-mediated MMC susceptibility was abrogated by dicumarol (DIC), an NQO1 inhibitor, indicating that NQO1 is one of the key regulators of arsenite-mediated MMC susceptibility.	arsenite	143-151	NAD(P)H quinone dehydrogenase 1	Homo sapiens	106-110
16494910-8	2006	Various cancer cell lines showed different basal levels of NQO1 activity and a different capacity for NQO1 induction in response to arsenite treatment.	arsenite	132-140	NAD(P)H quinone dehydrogenase 1	Homo sapiens	102-106
16494910-9	2006	However, overall, there was a positive correlation between induced NQO1 activity and MMC susceptibility in cells pretreated with various doses of arsenite.	arsenite	146-154	NAD(P)H quinone dehydrogenase 1	Homo sapiens	67-71
16494910-10	2006	These results suggest that arsenite may increase NQO1 activity and thus enhance the antineoplastic activity of MMC.	arsenite	27-35	NAD(P)H quinone dehydrogenase 1	Homo sapiens	49-53
16494910-11	2006	In addition, our results also showed that inhibition of NQO1 activity by DIC reversed the arsenite resistance of CL3R15 cells.	arsenite	90-98	NAD(P)H dehydrogenase, quinone 1	Mus musculus	56-60
16815819-6	2006	Arsenite induced expression of heat shock proteins Hsp72, Hsp32, and Hsp90, but endothelial nitric oxide synthase expression was not changed.	arsenite	0-8	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	51-56
16815819-6	2006	Arsenite induced expression of heat shock proteins Hsp72, Hsp32, and Hsp90, but endothelial nitric oxide synthase expression was not changed.	arsenite	0-8	heme oxygenase 1	Rattus norvegicus	58-63
16815819-6	2006	Arsenite induced expression of heat shock proteins Hsp72, Hsp32, and Hsp90, but endothelial nitric oxide synthase expression was not changed.	arsenite	0-8	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	69-74
16479312-6	2006	Transfection of OATP-C increased uptake and cytotoxicity of arsenate and arsenite, but not of MMA(V) or DMA(V).	arsenite	73-81	solute carrier organic anion transporter family member 1B1	Homo sapiens	16-22
16479312-7	2006	Rifampin and taurocholic acid (a substrate of OATP-C) reversed the increased toxicity of arsenate and arsenite seen in OATP-C-transfected cells.	arsenite	102-110	solute carrier organic anion transporter family member 1B1	Homo sapiens	119-125
16614167-0	2006	p53 suppression of arsenite-induced mitotic catastrophe is mediated by p21CIP1/WAF1.	arsenite	19-27	tumor protein p53	Homo sapiens	0-3
16773642-10	2006	Therefore, based on depolarization of mitochondria and the externalization of phosphatidylserine, HK-2 cells appear to initiate apoptosis following subcytotoxic arsenite insult, but morphological changes indicate that HK-2 cells fail to complete apoptosis and ultimately undergo necrosis.	arsenite	161-169	hexokinase 2	Homo sapiens	98-102
16614167-0	2006	p53 suppression of arsenite-induced mitotic catastrophe is mediated by p21CIP1/WAF1.	arsenite	19-27	cyclin dependent kinase inhibitor 1A	Homo sapiens	71-78
16614167-0	2006	p53 suppression of arsenite-induced mitotic catastrophe is mediated by p21CIP1/WAF1.	arsenite	19-27	cyclin dependent kinase inhibitor 1A	Homo sapiens	79-83
16614167-3	2006	Arsenite sensitivity correlates with deficient p53 pathways in multiple cell lines.	arsenite	0-8	tumor protein p53	Homo sapiens	47-50
16614167-4	2006	The role of p53 in preventing arsenite-induced mitotic arrest-associated apoptosis (MAAA), a form of mitotic catastrophe, was examined in TR9-7 cells, a model cell line with p53 exogenously regulated in a tetracycline-off expression system.	arsenite	30-38	tumor protein p53	Homo sapiens	12-15
16737587-16	2006	CONCLUSION: Sodium arsenite can induce expression of MRP2 and the up-regulation of MRP2 may play an important role in the bile secretion of arsenite and its metabolites.	arsenite	19-27	ATP binding cassette subfamily C member 2	Rattus norvegicus	53-57
16678800-5	2006	Here, we present evidence that carcinogenic metals such as arsenite, vanadate, and cobalt, induce AMPK activation and VEGF expression via several different mechanisms, and that AMPK is able to regulate the expression of VEGF mRNA in a hypoxia-inducible factor-1-dependent or -independent manner, depending on the metal applied.	arsenite	59-67	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	98-102
16678800-5	2006	Here, we present evidence that carcinogenic metals such as arsenite, vanadate, and cobalt, induce AMPK activation and VEGF expression via several different mechanisms, and that AMPK is able to regulate the expression of VEGF mRNA in a hypoxia-inducible factor-1-dependent or -independent manner, depending on the metal applied.	arsenite	59-67	vascular endothelial growth factor A	Homo sapiens	118-122
16678800-5	2006	Here, we present evidence that carcinogenic metals such as arsenite, vanadate, and cobalt, induce AMPK activation and VEGF expression via several different mechanisms, and that AMPK is able to regulate the expression of VEGF mRNA in a hypoxia-inducible factor-1-dependent or -independent manner, depending on the metal applied.	arsenite	59-67	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	177-181
16678800-5	2006	Here, we present evidence that carcinogenic metals such as arsenite, vanadate, and cobalt, induce AMPK activation and VEGF expression via several different mechanisms, and that AMPK is able to regulate the expression of VEGF mRNA in a hypoxia-inducible factor-1-dependent or -independent manner, depending on the metal applied.	arsenite	59-67	vascular endothelial growth factor A	Homo sapiens	220-224
16614167-6	2006	Cyclin B/CDC2(CDK1) stabilization and caspase-3 activation persisted in arsenite-treated p53- cells consistent with MAAA/mitotic catastrophe.	arsenite	72-80	cyclin dependent kinase 1	Homo sapiens	9-13
16614167-6	2006	Cyclin B/CDC2(CDK1) stabilization and caspase-3 activation persisted in arsenite-treated p53- cells consistent with MAAA/mitotic catastrophe.	arsenite	72-80	cyclin dependent kinase 1	Homo sapiens	14-18
16614167-6	2006	Cyclin B/CDC2(CDK1) stabilization and caspase-3 activation persisted in arsenite-treated p53- cells consistent with MAAA/mitotic catastrophe.	arsenite	72-80	caspase 3	Homo sapiens	38-47
16614167-6	2006	Cyclin B/CDC2(CDK1) stabilization and caspase-3 activation persisted in arsenite-treated p53- cells consistent with MAAA/mitotic catastrophe.	arsenite	72-80	tumor protein p53	Homo sapiens	89-92
16614167-9	2006	CDC2-Y15-P was transiently elevated in arsenite-treated p53+ cells but persisted in p53- cells.	arsenite	39-47	cyclin dependent kinase 1	Homo sapiens	0-4
16614167-9	2006	CDC2-Y15-P was transiently elevated in arsenite-treated p53+ cells but persisted in p53- cells.	arsenite	39-47	tumor protein p53	Homo sapiens	56-59
16614167-10	2006	Arsenite induced p53-S15-P and p21CIP1/WAF1 only in p53+ cells.	arsenite	0-8	tumor protein p53	Homo sapiens	17-20
16614167-10	2006	Arsenite induced p53-S15-P and p21CIP1/WAF1 only in p53+ cells.	arsenite	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	31-38
16614167-10	2006	Arsenite induced p53-S15-P and p21CIP1/WAF1 only in p53+ cells.	arsenite	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	39-43
16614167-10	2006	Arsenite induced p53-S15-P and p21CIP1/WAF1 only in p53+ cells.	arsenite	0-8	tumor protein p53	Homo sapiens	52-55
16376500-0	2006	A keratin 18 transgenic zebrafish Tg(k18(2.9):RFP) treated with inorganic arsenite reveals visible overproliferation of epithelial cells.	arsenite	74-82	keratin 18a, tandem duplicate 1	Danio rerio	2-12
16487513-6	2006	Furthermore, silencing COX-2 expression by specific RNAi also effectively increased surface FasL expression following arsenite treatment.	arsenite	118-126	prostaglandin-endoperoxide synthase 2	Homo sapiens	23-28
16487513-6	2006	Furthermore, silencing COX-2 expression by specific RNAi also effectively increased surface FasL expression following arsenite treatment.	arsenite	118-126	Fas ligand	Homo sapiens	92-96
16487513-8	2006	Data obtained demonstrate that the combination of arsenite with inhibitors of COX-2 may affect the target cancer cells via induction of FasL-mediated death signaling.	arsenite	50-58	prostaglandin-endoperoxide synthase 2	Homo sapiens	78-83
16487513-8	2006	Data obtained demonstrate that the combination of arsenite with inhibitors of COX-2 may affect the target cancer cells via induction of FasL-mediated death signaling.	arsenite	50-58	Fas ligand	Homo sapiens	136-140
16447264-2	2006	We show here that arsenite is a ubiquitous inducer of the heat shock response in mammalian cells: that it activated heat shock transcription factor 1 (HSF1) DNA-binding activity, enhanced hsp 70 promoter, and induced hsp70mRNA and synthesis of HSP chaperones.	arsenite	18-26	heat shock transcription factor 1	Homo sapiens	116-149
16447264-2	2006	We show here that arsenite is a ubiquitous inducer of the heat shock response in mammalian cells: that it activated heat shock transcription factor 1 (HSF1) DNA-binding activity, enhanced hsp 70 promoter, and induced hsp70mRNA and synthesis of HSP chaperones.	arsenite	18-26	heat shock transcription factor 1	Homo sapiens	151-155
16447264-2	2006	We show here that arsenite is a ubiquitous inducer of the heat shock response in mammalian cells: that it activated heat shock transcription factor 1 (HSF1) DNA-binding activity, enhanced hsp 70 promoter, and induced hsp70mRNA and synthesis of HSP chaperones.	arsenite	18-26	heat shock protein family A (Hsp70) member 4	Homo sapiens	188-194
16447264-2	2006	We show here that arsenite is a ubiquitous inducer of the heat shock response in mammalian cells: that it activated heat shock transcription factor 1 (HSF1) DNA-binding activity, enhanced hsp 70 promoter, and induced hsp70mRNA and synthesis of HSP chaperones.	arsenite	18-26	heat shock protein family A (Hsp70) member 4	Homo sapiens	217-222
16447264-3	2006	Using a high throughput hsp70 promoter-luciferase reporter assay, we observed a hormetic dose response where low concentrations of arsenite stimulated and high concentrations inhibited.	arsenite	131-139	heat shock protein family A (Hsp70) member 4	Homo sapiens	24-29
16447264-5	2006	The effect of arsenite in inducing the hsp 70-luciferase reporter absolutely required a functional HSF1 as it was not observed in HSF1 minus cells but re-instated by expression of HSF1.	arsenite	14-22	heat shock protein family A (Hsp70) member 4	Homo sapiens	39-45
16447264-5	2006	The effect of arsenite in inducing the hsp 70-luciferase reporter absolutely required a functional HSF1 as it was not observed in HSF1 minus cells but re-instated by expression of HSF1.	arsenite	14-22	heat shock transcription factor 1	Homo sapiens	99-103
16447264-5	2006	The effect of arsenite in inducing the hsp 70-luciferase reporter absolutely required a functional HSF1 as it was not observed in HSF1 minus cells but re-instated by expression of HSF1.	arsenite	14-22	heat shock transcription factor 1	Homo sapiens	130-134
16447264-5	2006	The effect of arsenite in inducing the hsp 70-luciferase reporter absolutely required a functional HSF1 as it was not observed in HSF1 minus cells but re-instated by expression of HSF1.	arsenite	14-22	heat shock transcription factor 1	Homo sapiens	130-134
16447264-7	2006	Assays of cell viability and caspase showed that arsenite caused a dose-dependent increase in cell death by activation of caspase 3/7 and pre-induction of HSPs blunted these effects.	arsenite	49-57	caspase 3	Homo sapiens	122-131
16737587-16	2006	CONCLUSION: Sodium arsenite can induce expression of MRP2 and the up-regulation of MRP2 may play an important role in the bile secretion of arsenite and its metabolites.	arsenite	19-27	ATP binding cassette subfamily C member 2	Rattus norvegicus	83-87
16387740-0	2006	Essential roles of PI-3K/Akt/IKKbeta/NFkappaB pathway in cyclin D1 induction by arsenite in JB6 Cl41 cells.	arsenite	80-88	thymoma viral proto-oncogene 1	Mus musculus	25-28
16567632-1	2006	Endogenous plant arsenate reductase (ACR) activity converts arsenate to arsenite in roots, immobilizing arsenic below ground.	arsenite	72-80	Rhodanese/Cell cycle control phosphatase superfamily protein	Arabidopsis thaliana	17-35
16387740-0	2006	Essential roles of PI-3K/Akt/IKKbeta/NFkappaB pathway in cyclin D1 induction by arsenite in JB6 Cl41 cells.	arsenite	80-88	inhibitor of kappaB kinase beta	Mus musculus	29-36
16387740-0	2006	Essential roles of PI-3K/Akt/IKKbeta/NFkappaB pathway in cyclin D1 induction by arsenite in JB6 Cl41 cells.	arsenite	80-88	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	37-45
16387740-0	2006	Essential roles of PI-3K/Akt/IKKbeta/NFkappaB pathway in cyclin D1 induction by arsenite in JB6 Cl41 cells.	arsenite	80-88	cyclin D1	Mus musculus	57-66
16387740-3	2006	Cyclin D1, a nuclear protein playing a pivotal role in cell proliferation and cell cycle transition from G1 to S phases, has been reported to be induced in human fibroblast by arsenite via uncertain molecular mechanisms.	arsenite	176-184	cyclin D1	Homo sapiens	0-9
16387740-4	2006	In the present study, the potential roles of PI-3K/Akt/IKKbeta/NFkappaB signal pathway in cyclin D1 induction by arsenite were addressed in mouse epidermal Cl41 cells.	arsenite	113-121	thymoma viral proto-oncogene 1	Mus musculus	51-54
16387740-4	2006	In the present study, the potential roles of PI-3K/Akt/IKKbeta/NFkappaB signal pathway in cyclin D1 induction by arsenite were addressed in mouse epidermal Cl41 cells.	arsenite	113-121	inhibitor of kappaB kinase beta	Mus musculus	55-62
16387740-4	2006	In the present study, the potential roles of PI-3K/Akt/IKKbeta/NFkappaB signal pathway in cyclin D1 induction by arsenite were addressed in mouse epidermal Cl41 cells.	arsenite	113-121	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	63-71
16387740-4	2006	In the present study, the potential roles of PI-3K/Akt/IKKbeta/NFkappaB signal pathway in cyclin D1 induction by arsenite were addressed in mouse epidermal Cl41 cells.	arsenite	113-121	cyclin D1	Mus musculus	90-99
16387740-5	2006	We found that exposure of Cl41 cells to arsenite was able to induce cell proliferation, activate PI-3K-->Akt/p70(S6k) signal pathway and increase cyclin D1 expression at both transcription and protein levels.	arsenite	40-48	thymoma viral proto-oncogene 1	Mus musculus	108-111
16387740-5	2006	We found that exposure of Cl41 cells to arsenite was able to induce cell proliferation, activate PI-3K-->Akt/p70(S6k) signal pathway and increase cyclin D1 expression at both transcription and protein levels.	arsenite	40-48	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	112-119
16387740-5	2006	We found that exposure of Cl41 cells to arsenite was able to induce cell proliferation, activate PI-3K-->Akt/p70(S6k) signal pathway and increase cyclin D1 expression at both transcription and protein levels.	arsenite	40-48	cyclin D1	Mus musculus	149-158
16387740-6	2006	Pre-treatment of Cl41 cells with PI-3K inhibitor, wortmannin, significantly inhibited the phosphorylation of Akt and p70(S6k) and thereby dramatically impaired the cyclin D1 induction by arsenite, implicating the importance of the PI-3K signal pathway in the cyclin D1 induction by arsenite.	arsenite	187-195	thymoma viral proto-oncogene 1	Mus musculus	109-112
16387740-6	2006	Pre-treatment of Cl41 cells with PI-3K inhibitor, wortmannin, significantly inhibited the phosphorylation of Akt and p70(S6k) and thereby dramatically impaired the cyclin D1 induction by arsenite, implicating the importance of the PI-3K signal pathway in the cyclin D1 induction by arsenite.	arsenite	187-195	cyclin D1	Mus musculus	164-173
16387740-6	2006	Pre-treatment of Cl41 cells with PI-3K inhibitor, wortmannin, significantly inhibited the phosphorylation of Akt and p70(S6k) and thereby dramatically impaired the cyclin D1 induction by arsenite, implicating the importance of the PI-3K signal pathway in the cyclin D1 induction by arsenite.	arsenite	187-195	cyclin D1	Mus musculus	259-268
16387740-6	2006	Pre-treatment of Cl41 cells with PI-3K inhibitor, wortmannin, significantly inhibited the phosphorylation of Akt and p70(S6k) and thereby dramatically impaired the cyclin D1 induction by arsenite, implicating the importance of the PI-3K signal pathway in the cyclin D1 induction by arsenite.	arsenite	282-290	thymoma viral proto-oncogene 1	Mus musculus	109-112
16387740-7	2006	Furthermore, inhibition of PI-3K/Akt by overexpression of Deltap85 or DN-Akt blocked arsenite-induced IKK phosphorylation, IkappaBalpha degradation and cyclin D1 expression, indicating that IKK/NFkappaB is the downstream transducer of arsenite-triggered PI-3K/Akt cascade.	arsenite	85-93	thymoma viral proto-oncogene 1	Mus musculus	33-36
16387740-7	2006	Furthermore, inhibition of PI-3K/Akt by overexpression of Deltap85 or DN-Akt blocked arsenite-induced IKK phosphorylation, IkappaBalpha degradation and cyclin D1 expression, indicating that IKK/NFkappaB is the downstream transducer of arsenite-triggered PI-3K/Akt cascade.	arsenite	85-93	thymoma viral proto-oncogene 1	Mus musculus	73-76
16387740-7	2006	Furthermore, inhibition of PI-3K/Akt by overexpression of Deltap85 or DN-Akt blocked arsenite-induced IKK phosphorylation, IkappaBalpha degradation and cyclin D1 expression, indicating that IKK/NFkappaB is the downstream transducer of arsenite-triggered PI-3K/Akt cascade.	arsenite	85-93	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	123-135
16387740-7	2006	Furthermore, inhibition of PI-3K/Akt by overexpression of Deltap85 or DN-Akt blocked arsenite-induced IKK phosphorylation, IkappaBalpha degradation and cyclin D1 expression, indicating that IKK/NFkappaB is the downstream transducer of arsenite-triggered PI-3K/Akt cascade.	arsenite	85-93	cyclin D1	Mus musculus	152-161
16387740-7	2006	Furthermore, inhibition of PI-3K/Akt by overexpression of Deltap85 or DN-Akt blocked arsenite-induced IKK phosphorylation, IkappaBalpha degradation and cyclin D1 expression, indicating that IKK/NFkappaB is the downstream transducer of arsenite-triggered PI-3K/Akt cascade.	arsenite	85-93	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	194-202
16387740-7	2006	Furthermore, inhibition of PI-3K/Akt by overexpression of Deltap85 or DN-Akt blocked arsenite-induced IKK phosphorylation, IkappaBalpha degradation and cyclin D1 expression, indicating that IKK/NFkappaB is the downstream transducer of arsenite-triggered PI-3K/Akt cascade.	arsenite	85-93	thymoma viral proto-oncogene 1	Mus musculus	73-76
16387740-7	2006	Furthermore, inhibition of PI-3K/Akt by overexpression of Deltap85 or DN-Akt blocked arsenite-induced IKK phosphorylation, IkappaBalpha degradation and cyclin D1 expression, indicating that IKK/NFkappaB is the downstream transducer of arsenite-triggered PI-3K/Akt cascade.	arsenite	235-243	thymoma viral proto-oncogene 1	Mus musculus	33-36
16387740-8	2006	Moreover, inhibition of IKKbeta/NFkappaB signal pathway by overexpression of its dominant negative mutant, IKKbeta-KM, also significantly blocked arsenite-induced cyclin D1 expression.	arsenite	146-154	inhibitor of kappaB kinase beta	Mus musculus	24-31
16387740-8	2006	Moreover, inhibition of IKKbeta/NFkappaB signal pathway by overexpression of its dominant negative mutant, IKKbeta-KM, also significantly blocked arsenite-induced cyclin D1 expression.	arsenite	146-154	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	32-40
16387740-8	2006	Moreover, inhibition of IKKbeta/NFkappaB signal pathway by overexpression of its dominant negative mutant, IKKbeta-KM, also significantly blocked arsenite-induced cyclin D1 expression.	arsenite	146-154	inhibitor of kappaB kinase beta	Mus musculus	107-114
16387740-8	2006	Moreover, inhibition of IKKbeta/NFkappaB signal pathway by overexpression of its dominant negative mutant, IKKbeta-KM, also significantly blocked arsenite-induced cyclin D1 expression.	arsenite	146-154	cyclin D1	Mus musculus	163-172
16387740-9	2006	Overall, arsenite exposure triggered PI-3K/Akt/IKKbeta/NFkappaB signal cascade which in turn plays essential roles in inducing cyclin D1 expression.	arsenite	9-17	thymoma viral proto-oncogene 1	Mus musculus	43-46
16387740-9	2006	Overall, arsenite exposure triggered PI-3K/Akt/IKKbeta/NFkappaB signal cascade which in turn plays essential roles in inducing cyclin D1 expression.	arsenite	9-17	inhibitor of kappaB kinase beta	Mus musculus	47-54
16387740-9	2006	Overall, arsenite exposure triggered PI-3K/Akt/IKKbeta/NFkappaB signal cascade which in turn plays essential roles in inducing cyclin D1 expression.	arsenite	9-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	55-63
16387740-9	2006	Overall, arsenite exposure triggered PI-3K/Akt/IKKbeta/NFkappaB signal cascade which in turn plays essential roles in inducing cyclin D1 expression.	arsenite	9-17	cyclin D1	Mus musculus	127-136
16581540-3	2006	We have previously shown that aquaglyceroporin channels, including Escherichia coli GlpF, Saccharomyces cerevisiae Fps1p, AQP7, and AQP9 from rat and human, conduct trivalent inorganic arsenic [As(III)] as arsenic trioxide, the protonated form of arsenite.	arsenite	247-255	Fps1p	Saccharomyces cerevisiae S288C	115-120
16581540-3	2006	We have previously shown that aquaglyceroporin channels, including Escherichia coli GlpF, Saccharomyces cerevisiae Fps1p, AQP7, and AQP9 from rat and human, conduct trivalent inorganic arsenic [As(III)] as arsenic trioxide, the protonated form of arsenite.	arsenite	247-255	aquaporin 9	Homo sapiens	132-136
16484376-10	2006	After cells were subjected to arsenite-induced stress, RAP55 was detected in TIA-containing stress granules.	arsenite	30-38	LSM14A mRNA processing body assembly factor	Homo sapiens	55-60
16484376-13	2006	The results of this study show that RAP55 is a component of P-bodies in cells at rest and localizes in stress granules in arsenite-treated cells.	arsenite	122-130	LSM14A mRNA processing body assembly factor	Homo sapiens	36-41
16338954-7	2006	Concomitantly, arsenite markedly diminished the securin protein expression and induced the abnormal sister chromatid separation.	arsenite	15-23	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	48-55
16510718-0	2006	Fragile X mental retardation protein shifts between polyribosomes and stress granules after neuronal injury by arsenite stress or in vivo hippocampal electrode insertion.	arsenite	111-119	fragile X messenger ribonucleoprotein 1	Homo sapiens	0-36
16338954-0	2006	Depletion of securin increases arsenite-induced chromosome instability and apoptosis via a p53-independent pathway.	arsenite	31-39	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	13-20
16338954-8	2006	The depletion of securin proteins increased the induction of mitotic arrest, aberrant chromosome segregation, and apoptosis after arsenite treatment.	arsenite	130-138	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	17-24
16338954-10	2006	Arsenite raised the levels of phospho-p53 (serine-15) and p53 (DO-1) proteins in both the securin-wild-type and -null cells.	arsenite	0-8	tumor protein p53	Homo sapiens	38-41
16338954-10	2006	Arsenite raised the levels of phospho-p53 (serine-15) and p53 (DO-1) proteins in both the securin-wild-type and -null cells.	arsenite	0-8	tumor protein p53	Homo sapiens	58-61
16338954-10	2006	Arsenite raised the levels of phospho-p53 (serine-15) and p53 (DO-1) proteins in both the securin-wild-type and -null cells.	arsenite	0-8	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	90-97
16338954-11	2006	The p53-functional cells were more susceptible than the p53-mutational cells to arsenite on the cytotoxicity and apoptosis.	arsenite	80-88	tumor protein p53	Homo sapiens	4-7
16338954-11	2006	The p53-functional cells were more susceptible than the p53-mutational cells to arsenite on the cytotoxicity and apoptosis.	arsenite	80-88	tumor protein p53	Homo sapiens	56-59
16338954-12	2006	Besides, arsenite decreased the levels of securin proteins to a similar degree in both the p53-functional and -mutational cells.	arsenite	9-17	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	42-49
16338954-12	2006	Besides, arsenite decreased the levels of securin proteins to a similar degree in both the p53-functional and -mutational cells.	arsenite	9-17	tumor protein p53	Homo sapiens	91-94
16338954-13	2006	Together, it is the first time to demonstrate that the inhibition of securin expression induced by arsenite increases the chromosomal instability and apoptosis via a p53-independent pathway.	arsenite	99-107	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	69-76
16338954-13	2006	Together, it is the first time to demonstrate that the inhibition of securin expression induced by arsenite increases the chromosomal instability and apoptosis via a p53-independent pathway.	arsenite	99-107	tumor protein p53	Homo sapiens	166-169
16489010-10	2006	These results indicate that centrosome amplification is induced in arsenite-arrested mitotic CGL-2 cells in a spindle checkpoint-dependent manner and is involved in the induction of arsenite-induced mitotic death.	arsenite	182-190	granzyme H	Homo sapiens	93-98
16451733-0	2006	D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells.	arsenite	130-138	Mekk1	Drosophila melanogaster	0-7
16489010-0	2006	Induction of centrosome amplification during arsenite-induced mitotic arrest in CGL-2 cells.	arsenite	45-53	granzyme H	Homo sapiens	80-85
16489010-3	2006	We have previously shown that arsenite induces mitotic arrest, mitotic abnormalities, and mitotic death in CGL-2 cells.	arsenite	30-38	granzyme H	Homo sapiens	107-112
16489010-9	2006	Furthermore, termination of mitotic arrest by treatment of arsenite-arrested mitotic cells with cyclin-dependent kinase 1 inhibitors or by suppression of spindle checkpoint function by small interfering RNA-mediated silencing of BubR1 or Mad2 markedly reduced the induction of centrosome amplification and mitotic death in arsenite-treated cells.	arsenite	323-331	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	229-234
16489010-9	2006	Furthermore, termination of mitotic arrest by treatment of arsenite-arrested mitotic cells with cyclin-dependent kinase 1 inhibitors or by suppression of spindle checkpoint function by small interfering RNA-mediated silencing of BubR1 or Mad2 markedly reduced the induction of centrosome amplification and mitotic death in arsenite-treated cells.	arsenite	323-331	mitotic arrest deficient 2 like 1	Homo sapiens	238-242
16489010-10	2006	These results indicate that centrosome amplification is induced in arsenite-arrested mitotic CGL-2 cells in a spindle checkpoint-dependent manner and is involved in the induction of arsenite-induced mitotic death.	arsenite	67-75	granzyme H	Homo sapiens	93-98
16451733-0	2006	D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells.	arsenite	130-138	mitogen-activated protein kinase kinase kinase 4	Homo sapiens	48-53
16451733-0	2006	D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells.	arsenite	130-138	mitogen-activated protein kinase kinase kinase 4	Homo sapiens	54-58
16451733-0	2006	D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells.	arsenite	130-138	basket	Drosophila melanogaster	111-114
16451733-5	2006	RESULTS: Using Drosophila melanogaster S2 cells, we demonstrate here that cadmium and arsenite activate Drosophila JNK (D-JNK) via oxidative stress as well, thus providing a simpler model system to study JNK signaling.	arsenite	86-94	basket	Drosophila melanogaster	115-118
16451733-5	2006	RESULTS: Using Drosophila melanogaster S2 cells, we demonstrate here that cadmium and arsenite activate Drosophila JNK (D-JNK) via oxidative stress as well, thus providing a simpler model system to study JNK signaling.	arsenite	86-94	basket	Drosophila melanogaster	120-125
16451733-5	2006	RESULTS: Using Drosophila melanogaster S2 cells, we demonstrate here that cadmium and arsenite activate Drosophila JNK (D-JNK) via oxidative stress as well, thus providing a simpler model system to study JNK signaling.	arsenite	86-94	basket	Drosophila melanogaster	122-125
16451733-6	2006	To elucidate the signaling pathways that lead to activation of D-JNK in response to cadmium or arsenite, we employed RNA interference (RNAi) to knock down thirteen upstream regulators of D-JNK, either singly or in combinations of up to seven at a time.	arsenite	95-103	basket	Drosophila melanogaster	65-68
16451733-7	2006	CONCLUSION: D-MEKK1, the fly orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediates the activation of D-JNK by cadmium and arsenite.	arsenite	136-144	Mekk1	Drosophila melanogaster	12-19
16451733-7	2006	CONCLUSION: D-MEKK1, the fly orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediates the activation of D-JNK by cadmium and arsenite.	arsenite	136-144	mitogen-activated protein kinase kinase kinase 4	Homo sapiens	53-58
16451733-7	2006	CONCLUSION: D-MEKK1, the fly orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediates the activation of D-JNK by cadmium and arsenite.	arsenite	136-144	mitogen-activated protein kinase kinase kinase 4	Homo sapiens	59-63
16451733-7	2006	CONCLUSION: D-MEKK1, the fly orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediates the activation of D-JNK by cadmium and arsenite.	arsenite	136-144	basket	Drosophila melanogaster	117-120
16443159-6	2006	Increased iron levels in arsenite transformed cells should theoretically lead to higher ferritin and lower TfR in these cells than in controls.	arsenite	25-33	transferrin receptor	Homo sapiens	107-110
16114012-0	2006	Arsenite pre-conditioning reduces UVB-induced apoptosis in corneal epithelial cells through the anti-apoptotic activity of 27 kDa heat shock protein (HSP27).	arsenite	0-8	heat shock protein family B (small) member 1	Homo sapiens	150-155
16114012-4	2006	When cells were pre-conditioned with arsenite prior to UVB exposure, the UVB-induced cell death was reduced, and UVB-induced activation of caspases and DNA fragmentation was inhibited.	arsenite	37-45	caspase 9	Homo sapiens	139-147
16114012-5	2006	When cells were pre-treated with SB 203580, which inhibits HSP27 phosphorylation through inhibition of p38 MAP kinase activation, the arsenite-induced reduction of UVB-induced apoptosis was partially reversed.	arsenite	134-142	heat shock protein family B (small) member 1	Homo sapiens	59-64
16114012-5	2006	When cells were pre-treated with SB 203580, which inhibits HSP27 phosphorylation through inhibition of p38 MAP kinase activation, the arsenite-induced reduction of UVB-induced apoptosis was partially reversed.	arsenite	134-142	mitogen-activated protein kinase 14	Homo sapiens	103-106
16114012-6	2006	Arsenite pre-conditioning inhibited UVB-induced apoptosis in a two-phase pattern, which was temporally correlated with arsenite-induced HSP27 expression and phosphorylation.	arsenite	0-8	heat shock protein family B (small) member 1	Homo sapiens	136-141
16114012-6	2006	Arsenite pre-conditioning inhibited UVB-induced apoptosis in a two-phase pattern, which was temporally correlated with arsenite-induced HSP27 expression and phosphorylation.	arsenite	119-127	heat shock protein family B (small) member 1	Homo sapiens	136-141
16114012-7	2006	Neutralization of intracellular HSP27 with its antibody reduced arsenite"s inhibition of UVB-induced caspase3 activation.	arsenite	64-72	heat shock protein family B (small) member 1	Homo sapiens	32-37
16114012-7	2006	Neutralization of intracellular HSP27 with its antibody reduced arsenite"s inhibition of UVB-induced caspase3 activation.	arsenite	64-72	caspase 3	Homo sapiens	101-109
16990255-9	2006	Heat shock and arsenite exposure had opposing effects on ZBP1 isoforms: while ZBP1DeltaZalpha granules disassembled, full length ZBP1 accumulated in SGs.	arsenite	15-23	Z-DNA binding protein 1	Homo sapiens	57-61
16990255-9	2006	Heat shock and arsenite exposure had opposing effects on ZBP1 isoforms: while ZBP1DeltaZalpha granules disassembled, full length ZBP1 accumulated in SGs.	arsenite	15-23	Z-DNA binding protein 1	Homo sapiens	78-82
16322246-0	2005	Lack of poly(ADP-ribose) polymerase-1 gene product enhances cellular sensitivity to arsenite.	arsenite	84-92	poly(ADP-ribose) polymerase 1	Homo sapiens	8-37
16207941-0	2006	ERK activation in arsenite-treated G1-enriched CL3 cells contributes to survival, DNA repair inhibition, and micronucleus formation.	arsenite	18-26	mitogen-activated protein kinase 1	Mus musculus	0-3
16207941-1	2006	Arsenite is known to induce chromosomal damage and extracellular signal-regulated kinases 1/2 (ERK) signaling transduction pathway.	arsenite	0-8	mitogen-activated protein kinase 1	Mus musculus	51-93
16207941-1	2006	Arsenite is known to induce chromosomal damage and extracellular signal-regulated kinases 1/2 (ERK) signaling transduction pathway.	arsenite	0-8	mitogen-activated protein kinase 1	Mus musculus	95-98
16207941-4	2006	In this study, we investigate the roles of ERK activation in survival, micronucleus formation, and nucleotide excision repair (NER) synthesis in arsenite-treated G1-enriched CL3 human non-small-cell lung carcinoma cells.	arsenite	145-153	mitogen-activated protein kinase 1	Mus musculus	43-46
16207941-7	2006	Arsenite activated sustained-ERK signal in G1 cells whose suppression further decreased cell proliferation and survival and could lower the micronucleus induction.	arsenite	0-8	mitogen-activated protein kinase 1	Mus musculus	29-32
16207941-9	2006	Intriguingly, blockage of ERK activation recovered NER synthesis activity in the arsenite-treated G1 cells.	arsenite	81-89	mitogen-activated protein kinase 1	Mus musculus	26-29
16207941-10	2006	Together, these results suggest that ERK activation in arsenite-treated G1 cells counteracts cytotoxicity and contributes to genomic instability via NER synthesis inhibition and micronucleus induction.	arsenite	55-63	mitogen-activated protein kinase 1	Mus musculus	37-40
16322246-5	2005	Our study revealed that telomere attrition, probably owing to arsenite-induced oxidative stress, was much more pronounced in PARP-1-/- mouse embryonic fibroblasts (MEF; 40%) compared with PARP-1+/+ MEFs (10-20%).	arsenite	62-70	poly (ADP-ribose) polymerase family, member 1	Mus musculus	125-131
16322246-6	2005	Correlation observed between telomere reduction and apoptotic death in PARP-1 null cells strongly indicates that the telomere attrition might be a trigger for enhanced apoptotic death after arsenite treatment.	arsenite	190-198	poly(ADP-ribose) polymerase 1	Homo sapiens	71-77
16322246-7	2005	Elevated DNA damage detected by alkaline comet assay points to an impaired repair ability of arsenite-induced DNA lesions in PARP-1-/- MEFs.	arsenite	93-101	poly(ADP-ribose) polymerase 1	Homo sapiens	125-131
16322246-8	2005	Consistent with elevated DNA damage, increased micronuclei induction reflecting gross genomic instability was also observed in arsenite-treated PARP-1-/- MEFs.	arsenite	127-135	poly(ADP-ribose) polymerase 1	Homo sapiens	144-150
16322246-10	2005	Our results suggest an important role for PARP-1 gene product in the maintenance of chromosome-genome stability in response to arsenite-induced DNA damage.	arsenite	127-135	poly(ADP-ribose) polymerase 1	Homo sapiens	42-48
15907335-6	2005	However, arsenite treatment only reduced DEX-induced levels of CYP3A23 mRNA by 30%.	arsenite	9-17	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	63-70
15907335-7	2005	The effects of arsenite on CYP3A23 transcription were examined using a luciferase reporter construct containing 1.4 kb of the CYP3A23 promoter.	arsenite	15-23	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	27-34
15907335-0	2005	Arsenite decreases CYP3A23 induction in cultured rat hepatocytes by transcriptional and translational mechanisms.	arsenite	0-8	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	19-26
15907335-9	2005	Since arsenite abolished induction of CYP3A23 protein, but caused only a small decrease in CYP3A23 mRNA, the effects of arsenite on translation of CYP3A23 mRNA were investigated.	arsenite	6-14	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	38-45
15907335-4	2005	The present study investigated whether arsenite utilizes transcriptional or post-transcriptional mechanisms to decrease CYP3A23 in primary cultures of rat hepatocytes.	arsenite	39-47	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	120-127
15907335-5	2005	In these cultures, a 6-h treatment with 5 microM arsenite abolished dexamethasone (DEX)-mediated induction of CYP3A23 protein and activity, but did not inhibit general protein synthesis.	arsenite	49-57	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	110-117
15907335-10	2005	Polysomal distribution analysis showed that arsenite decreased translation by decreasing the DEX-mediated increase in CYP3A23 mRNA association with polyribosomes.	arsenite	44-52	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	118-125
15907335-11	2005	Arsenite did not decrease intracellular glutathione or increase lipid peroxidation, suggesting that the effect of arsenite on CYP3A23 does not involve oxidative stress.	arsenite	114-122	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	126-133
15907335-12	2005	Overall, the results suggest that low-level arsenite decreases both transcription and translation of CYP3A23 in primary rat hepatocyte cultures.	arsenite	44-52	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	101-108
16271621-0	2005	Arsenite enhances tumor necrosis factor-alpha-induced expression of vascular cell adhesion molecule-1.	arsenite	0-8	tumor necrosis factor	Homo sapiens	18-45
16008523-0	2005	Arsenite induces a cell stress-response gene, RTP801, through reactive oxygen species and transcription factors Elk-1 and CCAAT/enhancer-binding protein.	arsenite	0-8	ETS transcription factor ELK1	Homo sapiens	112-117
16008523-0	2005	Arsenite induces a cell stress-response gene, RTP801, through reactive oxygen species and transcription factors Elk-1 and CCAAT/enhancer-binding protein.	arsenite	0-8	CCAAT enhancer binding protein alpha	Homo sapiens	122-152
16008523-8	2005	Point mutations of the putative Elk-1 site and the C/EBP (CCAAT/enhancer-binding protein) site within this region were able to reduce the stimulatory effect of arsenite, indicating that Elk-1 and C/EBP are involved in transcriptional regulation of the RTP801 gene by arsenite.	arsenite	160-168	ETS transcription factor ELK1	Homo sapiens	32-37
16008523-8	2005	Point mutations of the putative Elk-1 site and the C/EBP (CCAAT/enhancer-binding protein) site within this region were able to reduce the stimulatory effect of arsenite, indicating that Elk-1 and C/EBP are involved in transcriptional regulation of the RTP801 gene by arsenite.	arsenite	160-168	CCAAT enhancer binding protein alpha	Homo sapiens	51-56
16008523-8	2005	Point mutations of the putative Elk-1 site and the C/EBP (CCAAT/enhancer-binding protein) site within this region were able to reduce the stimulatory effect of arsenite, indicating that Elk-1 and C/EBP are involved in transcriptional regulation of the RTP801 gene by arsenite.	arsenite	160-168	CCAAT enhancer binding protein alpha	Homo sapiens	58-88
16008523-8	2005	Point mutations of the putative Elk-1 site and the C/EBP (CCAAT/enhancer-binding protein) site within this region were able to reduce the stimulatory effect of arsenite, indicating that Elk-1 and C/EBP are involved in transcriptional regulation of the RTP801 gene by arsenite.	arsenite	160-168	ETS transcription factor ELK1	Homo sapiens	186-191
16008523-8	2005	Point mutations of the putative Elk-1 site and the C/EBP (CCAAT/enhancer-binding protein) site within this region were able to reduce the stimulatory effect of arsenite, indicating that Elk-1 and C/EBP are involved in transcriptional regulation of the RTP801 gene by arsenite.	arsenite	160-168	CCAAT enhancer binding protein alpha	Homo sapiens	196-201
16008523-8	2005	Point mutations of the putative Elk-1 site and the C/EBP (CCAAT/enhancer-binding protein) site within this region were able to reduce the stimulatory effect of arsenite, indicating that Elk-1 and C/EBP are involved in transcriptional regulation of the RTP801 gene by arsenite.	arsenite	267-275	ETS transcription factor ELK1	Homo sapiens	32-37
16008523-8	2005	Point mutations of the putative Elk-1 site and the C/EBP (CCAAT/enhancer-binding protein) site within this region were able to reduce the stimulatory effect of arsenite, indicating that Elk-1 and C/EBP are involved in transcriptional regulation of the RTP801 gene by arsenite.	arsenite	267-275	CCAAT enhancer binding protein alpha	Homo sapiens	51-56
16008523-8	2005	Point mutations of the putative Elk-1 site and the C/EBP (CCAAT/enhancer-binding protein) site within this region were able to reduce the stimulatory effect of arsenite, indicating that Elk-1 and C/EBP are involved in transcriptional regulation of the RTP801 gene by arsenite.	arsenite	267-275	CCAAT enhancer binding protein alpha	Homo sapiens	58-88
16008523-8	2005	Point mutations of the putative Elk-1 site and the C/EBP (CCAAT/enhancer-binding protein) site within this region were able to reduce the stimulatory effect of arsenite, indicating that Elk-1 and C/EBP are involved in transcriptional regulation of the RTP801 gene by arsenite.	arsenite	267-275	CCAAT enhancer binding protein alpha	Homo sapiens	196-201
16008523-9	2005	Furthermore, a gel mobility-shift assay demonstrated that arsenite was able to mount the rapid formation of a protein complex that bound the arsenic-responsive region as well as the C/EBP-containing sequence.	arsenite	58-66	CCAAT enhancer binding protein alpha	Homo sapiens	182-187
16008523-10	2005	The arsenite stimulation on RTP801 transcription was partly mediated by the ERK (extracellular-signal-regulated kinase) pathway, since the effect of RTP801 was inhibited by a selective ERK inhibitor.	arsenite	4-12	mitogen-activated protein kinase 1	Homo sapiens	76-79
16008523-10	2005	The arsenite stimulation on RTP801 transcription was partly mediated by the ERK (extracellular-signal-regulated kinase) pathway, since the effect of RTP801 was inhibited by a selective ERK inhibitor.	arsenite	4-12	mitogen-activated protein kinase 1	Homo sapiens	81-118
16008523-10	2005	The arsenite stimulation on RTP801 transcription was partly mediated by the ERK (extracellular-signal-regulated kinase) pathway, since the effect of RTP801 was inhibited by a selective ERK inhibitor.	arsenite	4-12	mitogen-activated protein kinase 1	Homo sapiens	185-188
16271621-6	2005	Our investigation revealed that, by depleting GSH, arsenite attenuated the TNF-alpha-induced VCAM-1 expression as well as a potentiation of AP-1 and an attenuation of NF-kappaB activations by TNF-alpha.	arsenite	51-59	tumor necrosis factor	Homo sapiens	75-84
16271621-6	2005	Our investigation revealed that, by depleting GSH, arsenite attenuated the TNF-alpha-induced VCAM-1 expression as well as a potentiation of AP-1 and an attenuation of NF-kappaB activations by TNF-alpha.	arsenite	51-59	vascular cell adhesion molecule 1	Homo sapiens	93-99
16271621-6	2005	Our investigation revealed that, by depleting GSH, arsenite attenuated the TNF-alpha-induced VCAM-1 expression as well as a potentiation of AP-1 and an attenuation of NF-kappaB activations by TNF-alpha.	arsenite	51-59	tumor necrosis factor	Homo sapiens	192-201
16271621-9	2005	In summary, we demonstrate that arsenite enhances the TNF-alpha-induced VCAM-1 expression in HUVECs via regulation of AP-1 and NF-kappaB activities in a GSH-sensitive manner.	arsenite	32-40	tumor necrosis factor	Homo sapiens	54-63
16271621-9	2005	In summary, we demonstrate that arsenite enhances the TNF-alpha-induced VCAM-1 expression in HUVECs via regulation of AP-1 and NF-kappaB activities in a GSH-sensitive manner.	arsenite	32-40	vascular cell adhesion molecule 1	Homo sapiens	72-78
16271621-9	2005	In summary, we demonstrate that arsenite enhances the TNF-alpha-induced VCAM-1 expression in HUVECs via regulation of AP-1 and NF-kappaB activities in a GSH-sensitive manner.	arsenite	32-40	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	118-122
16271621-9	2005	In summary, we demonstrate that arsenite enhances the TNF-alpha-induced VCAM-1 expression in HUVECs via regulation of AP-1 and NF-kappaB activities in a GSH-sensitive manner.	arsenite	32-40	nuclear factor kappa B subunit 1	Homo sapiens	127-136
16271621-0	2005	Arsenite enhances tumor necrosis factor-alpha-induced expression of vascular cell adhesion molecule-1.	arsenite	0-8	vascular cell adhesion molecule 1	Homo sapiens	68-101
16271621-3	2005	In this study, we investigated the effect of arsenite and its induction of glutathione (GSH) on vascular cell adhesion molecule-1 (VCAM-1) protein expression in human umbilical vein endothelial cells (HUVECs) in response to tumor necrosis factor-alpha (TNF-alpha), a typical proinflammatory cytokine.	arsenite	45-53	vascular cell adhesion molecule 1	Homo sapiens	96-129
16271621-3	2005	In this study, we investigated the effect of arsenite and its induction of glutathione (GSH) on vascular cell adhesion molecule-1 (VCAM-1) protein expression in human umbilical vein endothelial cells (HUVECs) in response to tumor necrosis factor-alpha (TNF-alpha), a typical proinflammatory cytokine.	arsenite	45-53	vascular cell adhesion molecule 1	Homo sapiens	131-137
16271621-4	2005	Our study demonstrated that arsenite pretreatment potentiated the TNF-alpha-induced VCAM-1 expression with up-regulations of both activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB).	arsenite	28-36	tumor necrosis factor	Homo sapiens	66-75
16271621-4	2005	Our study demonstrated that arsenite pretreatment potentiated the TNF-alpha-induced VCAM-1 expression with up-regulations of both activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB).	arsenite	28-36	vascular cell adhesion molecule 1	Homo sapiens	84-90
16271621-4	2005	Our study demonstrated that arsenite pretreatment potentiated the TNF-alpha-induced VCAM-1 expression with up-regulations of both activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB).	arsenite	28-36	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	130-149
16271621-4	2005	Our study demonstrated that arsenite pretreatment potentiated the TNF-alpha-induced VCAM-1 expression with up-regulations of both activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB).	arsenite	28-36	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	151-155
16271621-4	2005	Our study demonstrated that arsenite pretreatment potentiated the TNF-alpha-induced VCAM-1 expression with up-regulations of both activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB).	arsenite	28-36	nuclear factor kappa B subunit 1	Homo sapiens	184-193
16014739-6	2005	Gclm(-/-) mouse embryo fibroblasts (MEFs) are eight times more sensitive to arsenite-induced apoptotic death.	arsenite	76-84	glutamate-cysteine ligase, modifier subunit	Mus musculus	0-4
16239170-0	2005	Arsenite induces endothelial cytotoxicity by down-regulation of vascular endothelial nitric oxide synthase.	arsenite	0-8	nitric oxide synthase 3	Homo sapiens	73-106
16239170-3	2005	However, the role of eNOS in regulating the arsenite-induced vascular dysfunction still remains to be clarified.	arsenite	44-52	nitric oxide synthase 3	Homo sapiens	21-25
16239170-4	2005	In our present study, we investigated the effect of arsenite on Akt1 and eNOS and its involvement in cytotoxicity of vascular endothelial cells.	arsenite	52-60	AKT serine/threonine kinase 1	Homo sapiens	64-68
16239170-4	2005	In our present study, we investigated the effect of arsenite on Akt1 and eNOS and its involvement in cytotoxicity of vascular endothelial cells.	arsenite	52-60	nitric oxide synthase 3	Homo sapiens	73-77
16239170-5	2005	Our study demonstrated that arsenite decreased the protein levels of both Akt1 and eNOS accompanied with increased levels of ubiquitination of total cell lysates.	arsenite	28-36	AKT serine/threonine kinase 1	Homo sapiens	74-78
16239170-5	2005	Our study demonstrated that arsenite decreased the protein levels of both Akt1 and eNOS accompanied with increased levels of ubiquitination of total cell lysates.	arsenite	28-36	nitric oxide synthase 3	Homo sapiens	83-87
16239170-6	2005	We found that inhibition of the ubiquitin-proteasome pathway by MG-132 could partially protect Akt1 and eNOS from degradation by arsenite together with a proportional protection from the arsenite-induced cytoxicity.	arsenite	129-137	AKT serine/threonine kinase 1	Homo sapiens	95-99
16239170-6	2005	We found that inhibition of the ubiquitin-proteasome pathway by MG-132 could partially protect Akt1 and eNOS from degradation by arsenite together with a proportional protection from the arsenite-induced cytoxicity.	arsenite	129-137	nitric oxide synthase 3	Homo sapiens	104-108
16239170-7	2005	Moreover, up-regulation of eNOS protein expression significantly attenuated the arsenite-induced cytotoxicity and eNOS activity could be significantly inhibited after incubation with arsenite for 24 h in a cell-free system.	arsenite	80-88	nitric oxide synthase 3	Homo sapiens	27-31
16239170-7	2005	Moreover, up-regulation of eNOS protein expression significantly attenuated the arsenite-induced cytotoxicity and eNOS activity could be significantly inhibited after incubation with arsenite for 24 h in a cell-free system.	arsenite	183-191	nitric oxide synthase 3	Homo sapiens	27-31
16239170-7	2005	Moreover, up-regulation of eNOS protein expression significantly attenuated the arsenite-induced cytotoxicity and eNOS activity could be significantly inhibited after incubation with arsenite for 24 h in a cell-free system.	arsenite	183-191	nitric oxide synthase 3	Homo sapiens	114-118
16239170-8	2005	Our study indicated that endothelial eNOS activity could be attenuated by arsenite via the ubiquitin-proteasome-mediated degradation of Akt1/eNOS as well as via direct inhibition of eNOS activity.	arsenite	74-82	nitric oxide synthase 3	Homo sapiens	37-41
16239170-8	2005	Our study indicated that endothelial eNOS activity could be attenuated by arsenite via the ubiquitin-proteasome-mediated degradation of Akt1/eNOS as well as via direct inhibition of eNOS activity.	arsenite	74-82	AKT serine/threonine kinase 1	Homo sapiens	136-140
16239170-8	2005	Our study indicated that endothelial eNOS activity could be attenuated by arsenite via the ubiquitin-proteasome-mediated degradation of Akt1/eNOS as well as via direct inhibition of eNOS activity.	arsenite	74-82	nitric oxide synthase 3	Homo sapiens	141-145
16239170-8	2005	Our study indicated that endothelial eNOS activity could be attenuated by arsenite via the ubiquitin-proteasome-mediated degradation of Akt1/eNOS as well as via direct inhibition of eNOS activity.	arsenite	74-82	nitric oxide synthase 3	Homo sapiens	141-145
16239170-9	2005	Our study also demonstrated that eNOS actually played a protective role in arsenite-induced cytoxicity.	arsenite	75-83	nitric oxide synthase 3	Homo sapiens	33-37
16239170-10	2005	These observations supported the hypothesis that the impairment of eNOS function by arsenite is one of the mechanisms leading to vascular changes and diseases.	arsenite	84-92	nitric oxide synthase 3	Homo sapiens	67-71
15961264-0	2005	Inhibition of alpha7-nicotinic acetylcholine receptor expression by arsenite in the vascular endothelial cells.	arsenite	68-76	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	14-53
15961264-3	2005	In this study, we investigated the expression of the alpha7-nAChR in the arsenite-exposed vascular endothelial cells.	arsenite	73-81	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	53-65
15961264-7	2005	The level of alpha7-nAChR proteins was concentration dependently decreased in the arsenite-treated endothelial cells.	arsenite	82-90	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	13-25
15961264-11	2005	Together, our results indicate that arsenite can inhibit the alpha7-nAChR protein expression and cause the cell injury in the vascular endothelial cells.	arsenite	36-44	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	61-73
16166651-0	2005	Mutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arsenite.	arsenite	170-178	transformation related protein 53, pseudogene	Mus musculus	69-72
16166651-0	2005	Mutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arsenite.	arsenite	170-178	jun proto-oncogene	Mus musculus	77-82
16166651-0	2005	Mutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arsenite.	arsenite	170-178	jun proto-oncogene	Mus musculus	101-106
16166651-3	2005	We show that arsenite activates both the JNK/c-Jun and p53 pathways in cortical neurons, which together account for >95% of apoptosis, as determined by using the mixed-lineage kinase (JNK/c-Jun) pathway inhibitor CEP11004 and p53-null mice.	arsenite	13-21	mitogen-activated protein kinase 8	Mus musculus	41-44
16166651-3	2005	We show that arsenite activates both the JNK/c-Jun and p53 pathways in cortical neurons, which together account for >95% of apoptosis, as determined by using the mixed-lineage kinase (JNK/c-Jun) pathway inhibitor CEP11004 and p53-null mice.	arsenite	13-21	jun proto-oncogene	Mus musculus	45-50
16166651-3	2005	We show that arsenite activates both the JNK/c-Jun and p53 pathways in cortical neurons, which together account for >95% of apoptosis, as determined by using the mixed-lineage kinase (JNK/c-Jun) pathway inhibitor CEP11004 and p53-null mice.	arsenite	13-21	transformation related protein 53, pseudogene	Mus musculus	55-58
16166651-3	2005	We show that arsenite activates both the JNK/c-Jun and p53 pathways in cortical neurons, which together account for >95% of apoptosis, as determined by using the mixed-lineage kinase (JNK/c-Jun) pathway inhibitor CEP11004 and p53-null mice.	arsenite	13-21	mitogen-activated protein kinase 8	Mus musculus	187-190
16166651-3	2005	We show that arsenite activates both the JNK/c-Jun and p53 pathways in cortical neurons, which together account for >95% of apoptosis, as determined by using the mixed-lineage kinase (JNK/c-Jun) pathway inhibitor CEP11004 and p53-null mice.	arsenite	13-21	jun proto-oncogene	Mus musculus	191-196
16166651-3	2005	We show that arsenite activates both the JNK/c-Jun and p53 pathways in cortical neurons, which together account for >95% of apoptosis, as determined by using the mixed-lineage kinase (JNK/c-Jun) pathway inhibitor CEP11004 and p53-null mice.	arsenite	13-21	transformation related protein 53, pseudogene	Mus musculus	229-232
16230390-0	2005	Cyclin D1 induction through IkappaB kinase beta/nuclear factor-kappaB pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytes.	arsenite	97-105	cyclin D1	Homo sapiens	0-9
16230390-0	2005	Cyclin D1 induction through IkappaB kinase beta/nuclear factor-kappaB pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytes.	arsenite	97-105	inhibitor of kappaB kinase beta	Mus musculus	28-47
16230390-4	2005	Further studies found that arsenite exposure was able to induce cyclin D1 expression.	arsenite	27-35	cyclin D1	Homo sapiens	64-73
16230390-5	2005	The induction of cyclin D1 by arsenite required nuclear factor-kappaB (NF-kappaB) activation, because the inhibition of IkappaB phosphorylation by overexpression of the dominant-negative mutant, IKKbeta-KM, impaired arsenite-induced cyclin D1 expression and G1-S transition.	arsenite	30-38	cyclin D1	Homo sapiens	17-26
16230390-5	2005	The induction of cyclin D1 by arsenite required nuclear factor-kappaB (NF-kappaB) activation, because the inhibition of IkappaB phosphorylation by overexpression of the dominant-negative mutant, IKKbeta-KM, impaired arsenite-induced cyclin D1 expression and G1-S transition.	arsenite	30-38	nuclear factor kappa B subunit 1	Homo sapiens	71-80
16230390-5	2005	The induction of cyclin D1 by arsenite required nuclear factor-kappaB (NF-kappaB) activation, because the inhibition of IkappaB phosphorylation by overexpression of the dominant-negative mutant, IKKbeta-KM, impaired arsenite-induced cyclin D1 expression and G1-S transition.	arsenite	30-38	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	195-202
16230390-5	2005	The induction of cyclin D1 by arsenite required nuclear factor-kappaB (NF-kappaB) activation, because the inhibition of IkappaB phosphorylation by overexpression of the dominant-negative mutant, IKKbeta-KM, impaired arsenite-induced cyclin D1 expression and G1-S transition.	arsenite	30-38	cyclin D1	Homo sapiens	233-242
16230390-5	2005	The induction of cyclin D1 by arsenite required nuclear factor-kappaB (NF-kappaB) activation, because the inhibition of IkappaB phosphorylation by overexpression of the dominant-negative mutant, IKKbeta-KM, impaired arsenite-induced cyclin D1 expression and G1-S transition.	arsenite	216-224	cyclin D1	Homo sapiens	17-26
16230390-6	2005	The requirement of IkappaB kinase beta (IKKbeta) for cyclin D1 induction was further confirmed by the findings that arsenite-induced cyclin D1 expression was totally blocked in IKKbeta knockout (IKKbeta(-/-)) mouse embryo fibroblasts.	arsenite	116-124	inhibitor of kappaB kinase beta	Mus musculus	19-38
16230390-6	2005	The requirement of IkappaB kinase beta (IKKbeta) for cyclin D1 induction was further confirmed by the findings that arsenite-induced cyclin D1 expression was totally blocked in IKKbeta knockout (IKKbeta(-/-)) mouse embryo fibroblasts.	arsenite	116-124	inhibitor of kappaB kinase beta	Mus musculus	40-47
16230390-6	2005	The requirement of IkappaB kinase beta (IKKbeta) for cyclin D1 induction was further confirmed by the findings that arsenite-induced cyclin D1 expression was totally blocked in IKKbeta knockout (IKKbeta(-/-)) mouse embryo fibroblasts.	arsenite	116-124	cyclin D1	Mus musculus	53-62
16230390-6	2005	The requirement of IkappaB kinase beta (IKKbeta) for cyclin D1 induction was further confirmed by the findings that arsenite-induced cyclin D1 expression was totally blocked in IKKbeta knockout (IKKbeta(-/-)) mouse embryo fibroblasts.	arsenite	116-124	cyclin D1	Mus musculus	133-142
16230390-6	2005	The requirement of IkappaB kinase beta (IKKbeta) for cyclin D1 induction was further confirmed by the findings that arsenite-induced cyclin D1 expression was totally blocked in IKKbeta knockout (IKKbeta(-/-)) mouse embryo fibroblasts.	arsenite	116-124	inhibitor of kappaB kinase beta	Mus musculus	177-207
16230390-7	2005	In addition, knockdown of cyclin D1 expression using cyclin D1-specific small interference RNA significantly blocked arsenite-induced cell cycle progression in HaCat cells.	arsenite	117-125	cyclin D1	Homo sapiens	26-35
16230390-7	2005	In addition, knockdown of cyclin D1 expression using cyclin D1-specific small interference RNA significantly blocked arsenite-induced cell cycle progression in HaCat cells.	arsenite	117-125	cyclin D1	Homo sapiens	53-62
16230390-8	2005	Taken together, our results show that arsenite-induced cell cycle from G(1) to S phase transition is through IKKbeta/NF-kappaB/cyclin D1-dependent pathway.	arsenite	38-46	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	109-116
16230390-8	2005	Taken together, our results show that arsenite-induced cell cycle from G(1) to S phase transition is through IKKbeta/NF-kappaB/cyclin D1-dependent pathway.	arsenite	38-46	nuclear factor kappa B subunit 1	Homo sapiens	117-126
16230390-8	2005	Taken together, our results show that arsenite-induced cell cycle from G(1) to S phase transition is through IKKbeta/NF-kappaB/cyclin D1-dependent pathway.	arsenite	38-46	cyclin D1	Homo sapiens	127-136
16333752-3	2005	We have evaluated the responses of wild-type and gcs-1 mutant nematodes to both inorganic arsenite (As(III)) and arsenate (As(V)) ions and found that gcs-1 mutant nematodes are more sensitive to arsenic toxicity than that of wild-type animals.	arsenite	90-98	Glutamate--cysteine ligase	Caenorhabditis elegans	49-54
16014739-7	2005	Because of a dramatic decrease in glutathione levels, Gclm(-/-) MEFs have a high prooxidant status that is not significantly relieved by treatment with the phenolic antioxidant tBHQ; however, tBHQ blocks arsenite-induced apoptosis in both Gclm(+/+) and Gclm(-/-) cells, although it raises a significant antioxidant response only in Gclm(+/+) cells.	arsenite	204-212	glutamate-cysteine ligase, modifier subunit	Mus musculus	54-58
16014739-8	2005	Global gene expression profiles indicate that tBHQ is significantly effective in reversing arsenite-induced gene deregulation in Gclm(+/+) but not in Gclm(-/-) MEFs.	arsenite	91-99	glutamate-cysteine ligase, modifier subunit	Mus musculus	129-133
16160914-5	2005	Expression of mRNA coding for TNF-alpha and IL-6 in liver was significantly lower in arsenite-pretreated animals.	arsenite	85-93	tumor necrosis factor	Mus musculus	30-39
16085347-6	2005	Co-incubation of N-HOS with As and CAPE (0.5-2.5 microM) prevented As-mediated declines in cytokine mRNAs in the co-treated cells, as well as their transformation to anchorage independence, while it caused decreases in c-jun mRNA.	arsenite	28-30	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	219-224
16160914-5	2005	Expression of mRNA coding for TNF-alpha and IL-6 in liver was significantly lower in arsenite-pretreated animals.	arsenite	85-93	interleukin 6	Mus musculus	44-48
15894712-0	2005	Arsenite-induced aryl hydrocarbon receptor nuclear translocation results in additive induction of phase I genes and synergistic induction of phase II genes.	arsenite	0-8	aryl-hydrocarbon receptor	Mus musculus	17-42
16102566-6	2005	Here, we characterize the metabolism and cytotoxicity of arsenite (iAs(III)) and methylated trivalent arsenicals in parental cells and clonal cells expressing AS3MT.	arsenite	57-65	arsenite methyltransferase	Homo sapiens	159-164
16054901-4	2005	Arsenite-treated cultures exhibited elevated levels of beta1-integrin and beta-catenin, two proteins enriched in cells with high proliferative potential.	arsenite	0-8	integrin subunit beta 1	Homo sapiens	55-69
16054901-4	2005	Arsenite-treated cultures exhibited elevated levels of beta1-integrin and beta-catenin, two proteins enriched in cells with high proliferative potential.	arsenite	0-8	catenin beta 1	Homo sapiens	74-86
15979568-0	2005	Mechanism of arsenite-mediated decreases in CYP3A23 in rat hepatocytes.	arsenite	13-21	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	44-51
15979568-1	2005	In primary cultures of rat hepatocytes, exposure to arsenite causes a major decrease in dexamethasone (DEX)-mediated induction of CYP3A23 hemoprotein, with a minor decrease in CYP3A23 mRNA.	arsenite	52-60	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	130-137
15979568-1	2005	In primary cultures of rat hepatocytes, exposure to arsenite causes a major decrease in dexamethasone (DEX)-mediated induction of CYP3A23 hemoprotein, with a minor decrease in CYP3A23 mRNA.	arsenite	52-60	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	176-183
15979568-3	2005	We also investigated whether arsenite decreases CYP3A23 protein by increasing CYP3A23 degradation by the calpain pathway.	arsenite	29-37	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	48-55
15979568-3	2005	We also investigated whether arsenite decreases CYP3A23 protein by increasing CYP3A23 degradation by the calpain pathway.	arsenite	29-37	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	78-85
15979568-5	2005	However, calpeptin enhanced the effect of arsenite to decrease induction of CYP3A23 protein.	arsenite	42-50	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	76-83
15979568-7	2005	Our findings suggest that CYP3A23 protein is not degraded by calpain-mediated proteolysis, even in the presence of arsenite.	arsenite	115-123	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	26-33
16087744-6	2005	Spc1 (Sty1) mitogen-activated protein kinase (MAPK), a homologue of mammalian p38 MAPK, and the upstream MAPK kinase (MAPKK) Wis1 are essential for survival of both arsenite and hydrogen peroxide.	arsenite	165-173	signal peptidase complex subunit 1	Homo sapiens	0-4
16087744-7	2005	Inactivation of two MAPKK kinases, Win1 and Wis4, almost completely eliminates Spc1 activation by arsenite, yet these cells survive arsenite treatment.	arsenite	98-106	signal peptidase complex subunit 1	Homo sapiens	79-83
15894712-6	2005	Treatment of mouse Hepa-1 cells with arsenite induces AHR nuclear translocation and binding to the Cyp1a1 gene promoter with the same efficiency as tetrachlorodibenzo-p-dioxin (TCDD), the most potent ligand of the AHR; however, TCDD and B[a]P are an order of magnitude more potent than arsenite in up-regulating Cyp1a1 transcription.	arsenite	286-294	aryl-hydrocarbon receptor	Mus musculus	54-57
16079067-7	2005	Arsenite decreased the UVR-induced caspase-3/7 activity in parallel with the inhibition of apoptosis.	arsenite	0-8	caspase 3	Mus musculus	35-44
15894712-5	2005	We have studied the effects of arsenite exposure on the activation of the aryl hydrocarbon receptor (AHR) and its subsequent role in gene transactivation.	arsenite	31-39	aryl-hydrocarbon receptor	Mus musculus	74-99
15894712-5	2005	We have studied the effects of arsenite exposure on the activation of the aryl hydrocarbon receptor (AHR) and its subsequent role in gene transactivation.	arsenite	31-39	aryl-hydrocarbon receptor	Mus musculus	101-104
15894712-6	2005	Treatment of mouse Hepa-1 cells with arsenite induces AHR nuclear translocation and binding to the Cyp1a1 gene promoter with the same efficiency as tetrachlorodibenzo-p-dioxin (TCDD), the most potent ligand of the AHR; however, TCDD and B[a]P are an order of magnitude more potent than arsenite in up-regulating Cyp1a1 transcription.	arsenite	37-45	aryl-hydrocarbon receptor	Mus musculus	54-57
15894712-6	2005	Treatment of mouse Hepa-1 cells with arsenite induces AHR nuclear translocation and binding to the Cyp1a1 gene promoter with the same efficiency as tetrachlorodibenzo-p-dioxin (TCDD), the most potent ligand of the AHR; however, TCDD and B[a]P are an order of magnitude more potent than arsenite in up-regulating Cyp1a1 transcription.	arsenite	37-45	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	99-105
15894712-6	2005	Treatment of mouse Hepa-1 cells with arsenite induces AHR nuclear translocation and binding to the Cyp1a1 gene promoter with the same efficiency as tetrachlorodibenzo-p-dioxin (TCDD), the most potent ligand of the AHR; however, TCDD and B[a]P are an order of magnitude more potent than arsenite in up-regulating Cyp1a1 transcription.	arsenite	37-45	aryl-hydrocarbon receptor	Mus musculus	214-217
15894712-6	2005	Treatment of mouse Hepa-1 cells with arsenite induces AHR nuclear translocation and binding to the Cyp1a1 gene promoter with the same efficiency as tetrachlorodibenzo-p-dioxin (TCDD), the most potent ligand of the AHR; however, TCDD and B[a]P are an order of magnitude more potent than arsenite in up-regulating Cyp1a1 transcription.	arsenite	37-45	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	312-318
15684421-0	2005	Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure.	arsenite	186-194	eukaryotic translation initiation factor 2 alpha kinase 1	Mus musculus	0-31
15734884-0	2005	EGF receptor-dependent JNK activation is involved in arsenite-induced p21Cip1/Waf1 upregulation and endothelial apoptosis.	arsenite	53-61	epidermal growth factor	Homo sapiens	0-3
15734884-0	2005	EGF receptor-dependent JNK activation is involved in arsenite-induced p21Cip1/Waf1 upregulation and endothelial apoptosis.	arsenite	53-61	mitogen-activated protein kinase 8	Homo sapiens	23-26
15734884-0	2005	EGF receptor-dependent JNK activation is involved in arsenite-induced p21Cip1/Waf1 upregulation and endothelial apoptosis.	arsenite	53-61	cyclin dependent kinase inhibitor 1A	Homo sapiens	70-77
15734884-0	2005	EGF receptor-dependent JNK activation is involved in arsenite-induced p21Cip1/Waf1 upregulation and endothelial apoptosis.	arsenite	53-61	cyclin dependent kinase inhibitor 1A	Homo sapiens	78-82
15734884-6	2005	We also found that arsenite-stimulated EGF (ErbB1) and ErbB2 receptor transactivation, manifest as receptor tyrosine phosphorylation, appeared to be a proximal signaling event leading to p21Cip1/Waf1 induction, because both pharmacological inhibitors and knockdown of receptors by RNA interference blocked arsenite-induced p21Cip1/Waf1 upregulation.	arsenite	19-27	epidermal growth factor	Homo sapiens	39-42
15734884-6	2005	We also found that arsenite-stimulated EGF (ErbB1) and ErbB2 receptor transactivation, manifest as receptor tyrosine phosphorylation, appeared to be a proximal signaling event leading to p21Cip1/Waf1 induction, because both pharmacological inhibitors and knockdown of receptors by RNA interference blocked arsenite-induced p21Cip1/Waf1 upregulation.	arsenite	19-27	epidermal growth factor receptor	Homo sapiens	44-49
15734884-6	2005	We also found that arsenite-stimulated EGF (ErbB1) and ErbB2 receptor transactivation, manifest as receptor tyrosine phosphorylation, appeared to be a proximal signaling event leading to p21Cip1/Waf1 induction, because both pharmacological inhibitors and knockdown of receptors by RNA interference blocked arsenite-induced p21Cip1/Waf1 upregulation.	arsenite	19-27	erb-b2 receptor tyrosine kinase 2	Homo sapiens	55-60
15734884-6	2005	We also found that arsenite-stimulated EGF (ErbB1) and ErbB2 receptor transactivation, manifest as receptor tyrosine phosphorylation, appeared to be a proximal signaling event leading to p21Cip1/Waf1 induction, because both pharmacological inhibitors and knockdown of receptors by RNA interference blocked arsenite-induced p21Cip1/Waf1 upregulation.	arsenite	19-27	cyclin dependent kinase inhibitor 1A	Homo sapiens	187-194
15833926-6	2005	Here, in primary cultures of human hepatocytes, we assessed the effects of acute arsenite exposure on CYP3A4 and several transcription factors involved in CYP3A4 expression.	arsenite	81-89	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	102-108
15833926-6	2005	Here, in primary cultures of human hepatocytes, we assessed the effects of acute arsenite exposure on CYP3A4 and several transcription factors involved in CYP3A4 expression.	arsenite	81-89	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	155-161
15833926-8	2005	Treatment with arsenite in the presence of CYP3A4 inducers, rifampicin (Rif) or phenobarbital, caused major decreases in CYP3A4 mRNA, protein, and activity.	arsenite	15-23	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	43-49
15833926-8	2005	Treatment with arsenite in the presence of CYP3A4 inducers, rifampicin (Rif) or phenobarbital, caused major decreases in CYP3A4 mRNA, protein, and activity.	arsenite	15-23	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	121-127
15833926-9	2005	In addition, the levels of CYP3A4 in untreated cells were decreased following arsenite treatment.	arsenite	78-86	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	27-33
15833926-11	2005	We found that arsenite failed to affect expression of PXR or the transcription factor Sp1, yet caused a significant decrease in PXR responsiveness to Rif.	arsenite	14-22	nuclear receptor subfamily 1 group I member 2	Homo sapiens	128-131
15833926-12	2005	Arsenite caused a large decrease in nuclear RXRalpha protein and, to a lesser extent, RXRalpha mRNA.	arsenite	0-8	retinoid X receptor alpha	Homo sapiens	44-52
15833926-12	2005	Arsenite caused a large decrease in nuclear RXRalpha protein and, to a lesser extent, RXRalpha mRNA.	arsenite	0-8	retinoid X receptor alpha	Homo sapiens	86-94
15833926-13	2005	These results suggest that arsenite inhibits both untreated and induced CYP3A4 transcription in primary human hepatocytes by decreasing the activity of PXR, as well as expression of the nuclear receptor RXRalpha.	arsenite	27-35	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	72-78
15833926-13	2005	These results suggest that arsenite inhibits both untreated and induced CYP3A4 transcription in primary human hepatocytes by decreasing the activity of PXR, as well as expression of the nuclear receptor RXRalpha.	arsenite	27-35	nuclear receptor subfamily 1 group I member 2	Homo sapiens	152-155
15833926-13	2005	These results suggest that arsenite inhibits both untreated and induced CYP3A4 transcription in primary human hepatocytes by decreasing the activity of PXR, as well as expression of the nuclear receptor RXRalpha.	arsenite	27-35	retinoid X receptor alpha	Homo sapiens	203-211
15944294-8	2005	In contrast, arsenite treatment enhanced stress granule localization of the MK2 mutant, consistent with the involvement of additional pathways regulating this event.	arsenite	13-21	MAPK activated protein kinase 2	Homo sapiens	76-79
15788408-0	2005	The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism.	arsenite	23-31	vascular endothelial growth factor A	Homo sapiens	42-76
15788408-0	2005	The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism.	arsenite	23-31	activating transcription factor 4	Homo sapiens	102-106
15788408-3	2005	Arsenite, a thiol-reactive oxidative stressor, induces VEGF expression by a HIF-1alpha-independent mechanism.	arsenite	0-8	vascular endothelial growth factor A	Homo sapiens	55-59
15788408-3	2005	Arsenite, a thiol-reactive oxidative stressor, induces VEGF expression by a HIF-1alpha-independent mechanism.	arsenite	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	76-86
15788408-5	2005	Because ATF4 is expressed in response to oxidative stress, we hypothesized that ATF4 was also responsible for increased VEGF transcription in response to arsenite.	arsenite	154-162	activating transcription factor 4	Homo sapiens	8-12
15788408-5	2005	Because ATF4 is expressed in response to oxidative stress, we hypothesized that ATF4 was also responsible for increased VEGF transcription in response to arsenite.	arsenite	154-162	activating transcription factor 4	Homo sapiens	80-84
15788408-5	2005	Because ATF4 is expressed in response to oxidative stress, we hypothesized that ATF4 was also responsible for increased VEGF transcription in response to arsenite.	arsenite	154-162	vascular endothelial growth factor A	Homo sapiens	120-124
15788408-6	2005	We now show that arsenite increased steady state levels of VEGF mRNA and activated transcription from a VEGF promoter construct.	arsenite	17-25	vascular endothelial growth factor A	Homo sapiens	59-63
15788408-6	2005	We now show that arsenite increased steady state levels of VEGF mRNA and activated transcription from a VEGF promoter construct.	arsenite	17-25	vascular endothelial growth factor A	Homo sapiens	104-108
15788408-7	2005	Arsenite induced eIF2alpha phosphorylation, resulting in increased ATF4 protein levels.	arsenite	0-8	eukaryotic translation initiation factor 2A	Homo sapiens	17-26
15788408-7	2005	Arsenite induced eIF2alpha phosphorylation, resulting in increased ATF4 protein levels.	arsenite	0-8	activating transcription factor 4	Homo sapiens	67-71
15788408-8	2005	Inactivation or loss of ATF4 greatly diminished the VEGF response to arsenite treatment.	arsenite	69-77	activating transcription factor 4	Homo sapiens	24-28
15788408-8	2005	Inactivation or loss of ATF4 greatly diminished the VEGF response to arsenite treatment.	arsenite	69-77	vascular endothelial growth factor A	Homo sapiens	52-56
15788408-10	2005	A complex containing ATF4 binds a DNA element at +1767 bp relative to the VEGF transcription start site, and DNA binding activity is increased by arsenite treatment.	arsenite	146-154	activating transcription factor 4	Homo sapiens	21-25
15788408-10	2005	A complex containing ATF4 binds a DNA element at +1767 bp relative to the VEGF transcription start site, and DNA binding activity is increased by arsenite treatment.	arsenite	146-154	vascular endothelial growth factor A	Homo sapiens	74-78
15741166-4	2005	Presently, small interference (si) RNA constructs were used to investigate the role of human BVR in sodium arsenite (As)-mediated induction of HO-1 and in cytoprotection against apoptosis.	arsenite	117-119	biliverdin reductase A	Homo sapiens	93-96
15741166-4	2005	Presently, small interference (si) RNA constructs were used to investigate the role of human BVR in sodium arsenite (As)-mediated induction of HO-1 and in cytoprotection against apoptosis.	arsenite	117-119	heme oxygenase 1	Homo sapiens	143-147
15963345-0	2005	Arsenite binding to synthetic peptides based on the Zn finger region and the estrogen binding region of the human estrogen receptor-alpha.	arsenite	0-8	estrogen receptor 1	Homo sapiens	114-137
15734884-6	2005	We also found that arsenite-stimulated EGF (ErbB1) and ErbB2 receptor transactivation, manifest as receptor tyrosine phosphorylation, appeared to be a proximal signaling event leading to p21Cip1/Waf1 induction, because both pharmacological inhibitors and knockdown of receptors by RNA interference blocked arsenite-induced p21Cip1/Waf1 upregulation.	arsenite	19-27	cyclin dependent kinase inhibitor 1A	Homo sapiens	195-199
15734884-6	2005	We also found that arsenite-stimulated EGF (ErbB1) and ErbB2 receptor transactivation, manifest as receptor tyrosine phosphorylation, appeared to be a proximal signaling event leading to p21Cip1/Waf1 induction, because both pharmacological inhibitors and knockdown of receptors by RNA interference blocked arsenite-induced p21Cip1/Waf1 upregulation.	arsenite	19-27	cyclin dependent kinase inhibitor 1A	Homo sapiens	323-330
15734884-6	2005	We also found that arsenite-stimulated EGF (ErbB1) and ErbB2 receptor transactivation, manifest as receptor tyrosine phosphorylation, appeared to be a proximal signaling event leading to p21Cip1/Waf1 induction, because both pharmacological inhibitors and knockdown of receptors by RNA interference blocked arsenite-induced p21Cip1/Waf1 upregulation.	arsenite	19-27	cyclin dependent kinase inhibitor 1A	Homo sapiens	331-335
15734884-6	2005	We also found that arsenite-stimulated EGF (ErbB1) and ErbB2 receptor transactivation, manifest as receptor tyrosine phosphorylation, appeared to be a proximal signaling event leading to p21Cip1/Waf1 induction, because both pharmacological inhibitors and knockdown of receptors by RNA interference blocked arsenite-induced p21Cip1/Waf1 upregulation.	arsenite	306-314	epidermal growth factor	Homo sapiens	39-42
15734884-6	2005	We also found that arsenite-stimulated EGF (ErbB1) and ErbB2 receptor transactivation, manifest as receptor tyrosine phosphorylation, appeared to be a proximal signaling event leading to p21Cip1/Waf1 induction, because both pharmacological inhibitors and knockdown of receptors by RNA interference blocked arsenite-induced p21Cip1/Waf1 upregulation.	arsenite	306-314	epidermal growth factor receptor	Homo sapiens	44-49
15734884-6	2005	We also found that arsenite-stimulated EGF (ErbB1) and ErbB2 receptor transactivation, manifest as receptor tyrosine phosphorylation, appeared to be a proximal signaling event leading to p21Cip1/Waf1 induction, because both pharmacological inhibitors and knockdown of receptors by RNA interference blocked arsenite-induced p21Cip1/Waf1 upregulation.	arsenite	306-314	erb-b2 receptor tyrosine kinase 2	Homo sapiens	55-60
15734884-6	2005	We also found that arsenite-stimulated EGF (ErbB1) and ErbB2 receptor transactivation, manifest as receptor tyrosine phosphorylation, appeared to be a proximal signaling event leading to p21Cip1/Waf1 induction, because both pharmacological inhibitors and knockdown of receptors by RNA interference blocked arsenite-induced p21Cip1/Waf1 upregulation.	arsenite	306-314	cyclin dependent kinase inhibitor 1A	Homo sapiens	187-194
15734884-7	2005	Arsenite-induced activation of JNK and p38 MAPK was distinct, with only JNK as a downstream target of the EGF receptor.	arsenite	0-8	mitogen-activated protein kinase 8	Homo sapiens	31-34
15734884-7	2005	Arsenite-induced activation of JNK and p38 MAPK was distinct, with only JNK as a downstream target of the EGF receptor.	arsenite	0-8	epidermal growth factor	Homo sapiens	106-109
15734884-9	2005	Functionally, inhibition of p21Cip1/Waf1 induction prevented endothelial apoptosis due to arsenite treatment.	arsenite	90-98	cyclin dependent kinase inhibitor 1A	Homo sapiens	28-35
15734884-9	2005	Functionally, inhibition of p21Cip1/Waf1 induction prevented endothelial apoptosis due to arsenite treatment.	arsenite	90-98	cyclin dependent kinase inhibitor 1A	Homo sapiens	36-40
15833926-0	2005	Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes.	arsenite	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	19-25
15833926-0	2005	Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes.	arsenite	0-8	retinoid X receptor alpha	Homo sapiens	30-38
15833926-5	2005	Acute exposure to arsenite decreases the induction of CYP1A1/2 proteins and activities in cultured human hepatocytes, as well as CYP3A23 in cultured rat hepatocytes.	arsenite	18-26	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	54-60
15521073-9	2005	We further found that in addition to cadmium, the activators of Nrf2, such as diethyl maleate (DEM) and arsenite, induced both TrxR1 and Trx gene expression in BAEC.	arsenite	104-112	NFE2 like bZIP transcription factor 2	Homo sapiens	64-68
15521073-9	2005	We further found that in addition to cadmium, the activators of Nrf2, such as diethyl maleate (DEM) and arsenite, induced both TrxR1 and Trx gene expression in BAEC.	arsenite	104-112	thioredoxin reductase 1	Homo sapiens	127-132
15521073-9	2005	We further found that in addition to cadmium, the activators of Nrf2, such as diethyl maleate (DEM) and arsenite, induced both TrxR1 and Trx gene expression in BAEC.	arsenite	104-112	thioredoxin	Homo sapiens	127-130
15788408-11	2005	In addition, the ability of a thiol antioxidant, N-acetylcysteine, to inhibit the effect of arsenite on VEGF expression coincided with its ability to inhibit phosphorylation of eIF2alpha and ATF4 protein expression.	arsenite	92-100	vascular endothelial growth factor A	Homo sapiens	104-108
15788408-11	2005	In addition, the ability of a thiol antioxidant, N-acetylcysteine, to inhibit the effect of arsenite on VEGF expression coincided with its ability to inhibit phosphorylation of eIF2alpha and ATF4 protein expression.	arsenite	92-100	eukaryotic translation initiation factor 2A	Homo sapiens	177-186
15788408-11	2005	In addition, the ability of a thiol antioxidant, N-acetylcysteine, to inhibit the effect of arsenite on VEGF expression coincided with its ability to inhibit phosphorylation of eIF2alpha and ATF4 protein expression.	arsenite	92-100	activating transcription factor 4	Homo sapiens	191-195
15788408-12	2005	Thus, arsenite-induced up-regulation of VEGF gene transcription occurs by an ATF4-dependent mechanism.	arsenite	6-14	vascular endothelial growth factor A	Homo sapiens	40-44
15788408-12	2005	Thus, arsenite-induced up-regulation of VEGF gene transcription occurs by an ATF4-dependent mechanism.	arsenite	6-14	activating transcription factor 4	Homo sapiens	77-81
15791647-0	2005	Involvement of protein kinase PKN1 in G2/M delay caused by arsenite.	arsenite	59-67	protein kinase N1	Homo sapiens	30-34
15791647-2	2005	We show here that in response to arsenite exposure, PKN1 kinase activity was stimulated, which was associated with increased binding of PKN1 to Cdc25C and delayed mitotic entry.	arsenite	33-41	protein kinase N1	Homo sapiens	52-56
15791647-2	2005	We show here that in response to arsenite exposure, PKN1 kinase activity was stimulated, which was associated with increased binding of PKN1 to Cdc25C and delayed mitotic entry.	arsenite	33-41	protein kinase N1	Homo sapiens	136-140
15791647-2	2005	We show here that in response to arsenite exposure, PKN1 kinase activity was stimulated, which was associated with increased binding of PKN1 to Cdc25C and delayed mitotic entry.	arsenite	33-41	cell division cycle 25C	Homo sapiens	144-150
15791647-3	2005	A role for PKN1 in mediating arsenite-induced G(2)/M delay was supported by the finding that expression of a constitutively active form of PKN1 (PKN1AF3) in HeLa cells delayed the mitotic entry of cell cycle.	arsenite	29-37	protein kinase N1	Homo sapiens	11-15
15791647-3	2005	A role for PKN1 in mediating arsenite-induced G(2)/M delay was supported by the finding that expression of a constitutively active form of PKN1 (PKN1AF3) in HeLa cells delayed the mitotic entry of cell cycle.	arsenite	29-37	protein kinase N1	Homo sapiens	139-143
15791647-3	2005	A role for PKN1 in mediating arsenite-induced G(2)/M delay was supported by the finding that expression of a constitutively active form of PKN1 (PKN1AF3) in HeLa cells delayed the mitotic entry of cell cycle.	arsenite	29-37	protein kinase N1	Homo sapiens	145-152
15791647-5	2005	Significantly, expression of a phosphorylation mutant of Cdc25C (S216A) partially abrogated the cell-cycle arrest in response to arsenite.	arsenite	129-137	cell division cycle 25C	Homo sapiens	57-63
15791647-6	2005	Together, our results suggest that PKN1 mediates arsenite-induced delay of the G(2)/M transition by binding to and phoshorylating Cdc25C.	arsenite	49-57	protein kinase N1	Homo sapiens	35-39
15791647-6	2005	Together, our results suggest that PKN1 mediates arsenite-induced delay of the G(2)/M transition by binding to and phoshorylating Cdc25C.	arsenite	49-57	cell division cycle 25C	Homo sapiens	130-136
15741166-0	2005	Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells.	arsenite	123-131	biliverdin reductase A	Homo sapiens	56-66
15781252-4	2005	The induction of hNIPK gene in response to thapsigargin and arsenite treatments is mediated by a promoter segment consisting of tandemly arranged 33-bp repeats that contain a regulatory element similar to C/EBP-ATF composite site of the Chop gene promoter.	arsenite	60-68	tribbles pseudokinase 3	Homo sapiens	17-22
15781252-4	2005	The induction of hNIPK gene in response to thapsigargin and arsenite treatments is mediated by a promoter segment consisting of tandemly arranged 33-bp repeats that contain a regulatory element similar to C/EBP-ATF composite site of the Chop gene promoter.	arsenite	60-68	DNA damage inducible transcript 3	Homo sapiens	237-241
15781252-5	2005	ATF4, whose level is upregulated in the cells exposed to thapsigargin or arsenite, is able to bind to the 33-bp repeat and activate the hNIPK promoter.	arsenite	73-81	activating transcription factor 4	Homo sapiens	0-4
15781252-5	2005	ATF4, whose level is upregulated in the cells exposed to thapsigargin or arsenite, is able to bind to the 33-bp repeat and activate the hNIPK promoter.	arsenite	73-81	tribbles pseudokinase 3	Homo sapiens	136-141
15526190-0	2005	A new metabolic pathway of arsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19.	arsenite	27-35	arsenite methyltransferase	Homo sapiens	100-123
15630080-0	2005	Arsenite inhibition of CYP1A1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is independent of cell cycle arrest.	arsenite	0-8	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	23-29
15630080-1	2005	We show here that arsenite (As(3+)) elicits multiple effects on gene control, such as the interruption of cell cycle control by initiating G(2)/M arrest as well as inhibiting the aryl hydrocarbon (Ah) receptor-mediated 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible expression of CYP1A1.	arsenite	18-26	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	286-292
15819251-1	2005	Oxidation of arsenite, As(III), to arsenate, As(V), is required for the efficient removal of arsenic by many water treatment technologies.	arsenite	13-21	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	45-50
15725613-7	2005	Following arsenite treatment or irradiation, a significant increase compared with that of the control was observed for glutathione (GSH) transferase omega 1 and proteasome subunit beta type 4 precursor.	arsenite	10-18	proteasome 20S subunit beta 4	Homo sapiens	119-191
15725613-10	2005	Ubiquinol-cytochrome C reductase complex core protein I, adenine phosphoribosyl transferase and endoplasmic reticulum protein hERp29 showed decreased levels after irradiation or arsenite treatment, but not after the combined exposure.	arsenite	178-186	endoplasmic reticulum protein 29	Homo sapiens	126-132
15576448-0	2005	Mechanisms of arsenite-mediated decreases in benzo[k]fluoranthene-induced human cytochrome P4501A1 levels in HepG2 cells.	arsenite	14-22	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	80-98
15576448-2	2005	The heavy metal, arsenite, and the PAH, benzo[k]fluoranthene, were used as prototypes to investigate, in human HepG2 cells, mechanisms whereby the bioactivation of benzo[k]fluoranthene by human CYP1A1 could be diminished by arsenite-mediated decreases in CYP1A1 induction by benzo[k]fluoranthene.	arsenite	224-232	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	194-200
15576448-3	2005	To determine whether arsenite down-regulates CYP1A1 transcription, quantitative real-time reverse transcriptase-polymerase chain reaction assays and luciferase reporter gene expression assays were used with HepG2 cells treated with benzo[k]fluoranthene and arsenite, separately and as a mixture.	arsenite	21-29	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	45-51
15576448-4	2005	Benzo[k]fluoranthene (0.5 microM) and arsenite (5 microM) markedly decreased benzo[k]fluoranthene-mediated induction of CYP1A1 mRNA by 45%.	arsenite	38-46	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	120-126
15576448-5	2005	Plasmids containing the CYP1A1 promoter region (pHu-1A1-FL) were induced 7.4-fold over vehicle by benzo[k]fluoranthene (0.5 microM), whereas arsenite (1, 2.5, or 5 microM) decreased reporter gene expression by 46%, 45%, and 61%, respectively.	arsenite	141-149	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	24-30
15576448-8	2005	Arsenite is stable for at least 48 h in the HepG2 cell medium with respect to its ability to diminish CYP1A1 benzo[k]fluoranthene induction.	arsenite	0-8	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	102-108
15576448-10	2005	Thus, arsenite affects the transcriptional regulation of the benzo[k]fluoranthene-mediated induction of CYP1A1 and could diminish PAH carcinogenicity by decreasing bioactivation by CYP1A1.	arsenite	6-14	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	104-110
15576448-10	2005	Thus, arsenite affects the transcriptional regulation of the benzo[k]fluoranthene-mediated induction of CYP1A1 and could diminish PAH carcinogenicity by decreasing bioactivation by CYP1A1.	arsenite	6-14	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	181-187
15684421-3	2005	Of the four protein kinases known to phosphorylate eukaryotic translation initiation factor 2alpha, only the heme-regulated inhibitor kinase (HRI) was required for the translational inhibition in response to arsenite treatment in mouse embryonic fibroblasts.	arsenite	208-216	eukaryotic translation initiation factor 2A	Mus musculus	51-98
15684421-3	2005	Of the four protein kinases known to phosphorylate eukaryotic translation initiation factor 2alpha, only the heme-regulated inhibitor kinase (HRI) was required for the translational inhibition in response to arsenite treatment in mouse embryonic fibroblasts.	arsenite	208-216	eukaryotic translation initiation factor 2 alpha kinase 1	Mus musculus	109-140
15684421-3	2005	Of the four protein kinases known to phosphorylate eukaryotic translation initiation factor 2alpha, only the heme-regulated inhibitor kinase (HRI) was required for the translational inhibition in response to arsenite treatment in mouse embryonic fibroblasts.	arsenite	208-216	eukaryotic translation initiation factor 2 alpha kinase 1	Mus musculus	142-145
15684421-4	2005	In addition, HRI expression was required for stress granule formation and cellular survival after arsenite treatment.	arsenite	98-106	eukaryotic translation initiation factor 2 alpha kinase 1	Mus musculus	13-16
15684421-5	2005	In vivo studies elucidated a fundamental requirement for HRI in murine survival upon acute arsenite exposure.	arsenite	91-99	eukaryotic translation initiation factor 2 alpha kinase 1	Mus musculus	57-60
15684421-6	2005	The results demonstrated an essential role for HRI in mediating arsenite stress-induced phosphorylation of eukaryotic translation initiation factor 2alpha, inhibition of protein synthesis, stress granule formation, and survival.	arsenite	64-72	eukaryotic translation initiation factor 2 alpha kinase 1	Mus musculus	47-50
15684421-6	2005	The results demonstrated an essential role for HRI in mediating arsenite stress-induced phosphorylation of eukaryotic translation initiation factor 2alpha, inhibition of protein synthesis, stress granule formation, and survival.	arsenite	64-72	eukaryotic translation initiation factor 2A	Mus musculus	107-154
15618017-1	2005	We examined a possible role for heat shock factor-1 (HSF-1) in the negative regulation of HO-1 gene expression in human Hep3B hepatoma cells responding to stimulation with 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and arsenite.	arsenite	224-232	heat shock transcription factor 1	Homo sapiens	53-58
15618017-2	2005	Overexpression of HSF-1 and heat-shock experiments indicated that HSF-1 repressed the 15d-PGJ2-and arsenite-induced HO-1 gene expression through directly binding to the consensus heat shock element (HSE) of the HO-1 gene promoter.	arsenite	99-107	heat shock transcription factor 1	Homo sapiens	18-23
15618017-2	2005	Overexpression of HSF-1 and heat-shock experiments indicated that HSF-1 repressed the 15d-PGJ2-and arsenite-induced HO-1 gene expression through directly binding to the consensus heat shock element (HSE) of the HO-1 gene promoter.	arsenite	99-107	heat shock transcription factor 1	Homo sapiens	66-71
15618017-2	2005	Overexpression of HSF-1 and heat-shock experiments indicated that HSF-1 repressed the 15d-PGJ2-and arsenite-induced HO-1 gene expression through directly binding to the consensus heat shock element (HSE) of the HO-1 gene promoter.	arsenite	99-107	heme oxygenase 1	Homo sapiens	116-120
15618017-2	2005	Overexpression of HSF-1 and heat-shock experiments indicated that HSF-1 repressed the 15d-PGJ2-and arsenite-induced HO-1 gene expression through directly binding to the consensus heat shock element (HSE) of the HO-1 gene promoter.	arsenite	99-107	heme oxygenase 1	Homo sapiens	211-215
15710175-3	2005	While arsenite was found to induce cell death in a culture system containing macrophage colony stimulating factor (M-CSF), macrophages induced by granulocyte-macrophage CSF (GM-CSF) survived the treatment, but were morphologically, phenotypically, and functionally altered.	arsenite	6-14	colony stimulating factor 1	Homo sapiens	115-120
15710175-4	2005	In particular, arsenite-induced cells expressed higher levels of a major histocompatibility complex (MHC) class II antigen, HLA-DR, and CD14.	arsenite	15-23	CD14 molecule	Homo sapiens	136-140
15601678-3	2005	Glutathione (GSH) is extensively involved in the metabolism of inorganic arsenic, and both arsenite and its methylated metabolites have been shown to be potent inhibitors of glutathione reductase (GR) in vitro.	arsenite	91-99	glutathione reductase	Mus musculus	174-195
15710175-6	2005	On the other hand, arsenite-induced cells expressed lower levels of CD11b and CD54 and phagocytosed latex beads or zymosan particles less efficiently.	arsenite	19-27	integrin subunit alpha M	Homo sapiens	68-73
15601678-3	2005	Glutathione (GSH) is extensively involved in the metabolism of inorganic arsenic, and both arsenite and its methylated metabolites have been shown to be potent inhibitors of glutathione reductase (GR) in vitro.	arsenite	91-99	glutathione reductase	Mus musculus	197-199
15710175-6	2005	On the other hand, arsenite-induced cells expressed lower levels of CD11b and CD54 and phagocytosed latex beads or zymosan particles less efficiently.	arsenite	19-27	intercellular adhesion molecule 1	Homo sapiens	78-82
15713539-0	2005	Novel signaling stimulated by arsenite increases cholesterol metabolism through increases in unphosphorylated steroidogenic acute regulatory (StAR) protein.	arsenite	30-38	steroidogenic acute regulatory protein	Mus musculus	142-146
15713539-4	2005	Arsenite produced parallel increases in StAR protein expression and cholesterol metabolism, but not for P450scc-mediated metabolism of 20alpha-hydroxycholesterol.	arsenite	0-8	steroidogenic acute regulatory protein	Mus musculus	40-44
15713539-7	2005	Arsenite and anisomycin each elevated StAR mRNA but preferentially increased the 3.5 kb form relative to the 1.6 kb form.	arsenite	0-8	steroidogenic acute regulatory protein	Mus musculus	38-42
15713539-5	2005	Although arsenite and anisomycin each stimulated the phosphorylation of p38, the p38 inhibitor SB203580 (SB) produced additive increases in StAR expression.	arsenite	9-17	mitogen-activated protein kinase 14	Mus musculus	72-75
15713539-10	2005	Arsenite and anisomycin may therefore activate a novel SB-independent MAP kinase which in part increases StAR expression through stabilizing the 3.5 kb mRNA but which may also activate a mechanism that by-passes transcription factors detected by the reporter.	arsenite	0-8	steroidogenic acute regulatory protein	Mus musculus	105-109
15580309-0	2005	Combined treatment with EGFR inhibitors and arsenite upregulated apoptosis in human EGFR-positive melanomas: a role of suppression of the PI3K-AKT pathway.	arsenite	44-52	epidermal growth factor receptor	Homo sapiens	84-88
15713539-12	2005	These activations contrast with inhibition of StAR expression by arsenite at higher concentrations or longer incubation times.	arsenite	65-73	steroidogenic acute regulatory protein	Mus musculus	46-50
15487973-11	2005	The phosphorylation of endogenous eIF4E in Drosophila cells is increased by activation of the ERK pathway but not by arsenite, an activator of p38 MAPK.	arsenite	117-125	eukaryotic translation initiation factor 4E1	Drosophila melanogaster	34-39
15590125-0	2005	Role of glutathione in reduction of arsenate and of gamma-glutamyltranspeptidase in disposition of arsenite in rats.	arsenite	99-107	gamma-glutamyltransferase 1	Rattus norvegicus	52-80
15580309-4	2005	We recently reported that arsenite, particularly in combination with inhibitors of the PI3K-AKT and mitogen-activated protein kinase (MAPK) kinase (MEK)-extracellular signal-regulated kinase (ERK) pathways, induces high levels of apoptosis in different melanomas.	arsenite	26-34	mitogen-activated protein kinase 1	Homo sapiens	134-138
15580309-4	2005	We recently reported that arsenite, particularly in combination with inhibitors of the PI3K-AKT and mitogen-activated protein kinase (MAPK) kinase (MEK)-extracellular signal-regulated kinase (ERK) pathways, induces high levels of apoptosis in different melanomas.	arsenite	26-34	mitogen-activated protein kinase kinase 7	Homo sapiens	148-151
15580309-4	2005	We recently reported that arsenite, particularly in combination with inhibitors of the PI3K-AKT and mitogen-activated protein kinase (MAPK) kinase (MEK)-extracellular signal-regulated kinase (ERK) pathways, induces high levels of apoptosis in different melanomas.	arsenite	26-34	mitogen-activated protein kinase 1	Homo sapiens	192-195
15580309-5	2005	Since EGFR signaling operates via activation of the PI3K-AKT and MEK-ERK pathways, we suggested that the combination of arsenite and EGFR inhibitors might also effectively induce apoptosis in melanoma.	arsenite	120-128	epidermal growth factor receptor	Homo sapiens	6-10
15580309-5	2005	Since EGFR signaling operates via activation of the PI3K-AKT and MEK-ERK pathways, we suggested that the combination of arsenite and EGFR inhibitors might also effectively induce apoptosis in melanoma.	arsenite	120-128	mitogen-activated protein kinase kinase 7	Homo sapiens	65-68
15580309-5	2005	Since EGFR signaling operates via activation of the PI3K-AKT and MEK-ERK pathways, we suggested that the combination of arsenite and EGFR inhibitors might also effectively induce apoptosis in melanoma.	arsenite	120-128	mitogen-activated protein kinase 1	Homo sapiens	69-72
15580309-6	2005	Here, we demonstrate that a moderate concentration of arsenite (5-10 muM) indeed upregulates apoptosis induced by EGFR inhibitors in EGFR-positive melanomas.	arsenite	54-62	epidermal growth factor receptor	Homo sapiens	114-118
15580309-6	2005	Here, we demonstrate that a moderate concentration of arsenite (5-10 muM) indeed upregulates apoptosis induced by EGFR inhibitors in EGFR-positive melanomas.	arsenite	54-62	epidermal growth factor receptor	Homo sapiens	133-137
15580309-7	2005	In contrast, induction of apoptosis in melanomas with negligible surface expression of EGFR or with defective EGFR signaling requires direct suppression of the PI3K-AKT and MAPK pathways by specific pharmacological inhibitors in the presence of arsenite.	arsenite	245-253	epidermal growth factor receptor	Homo sapiens	110-114
15580309-7	2005	In contrast, induction of apoptosis in melanomas with negligible surface expression of EGFR or with defective EGFR signaling requires direct suppression of the PI3K-AKT and MAPK pathways by specific pharmacological inhibitors in the presence of arsenite.	arsenite	245-253	mitogen-activated protein kinase 1	Homo sapiens	173-177
15849723-0	2005	Low levels of arsenite activates nuclear factor-kappaB and activator protein-1 in immortalized mesencephalic cells.	arsenite	14-22	jun proto-oncogene	Mus musculus	59-78
15471901-0	2005	Arsenite induces prominent mitotic arrest via inhibition of G2 checkpoint activation in CGL-2 cells.	arsenite	0-8	granzyme H	Homo sapiens	88-93
15471901-3	2005	In this study, we showed that arsenite could induce prominent mitotic arrest in CGL-2 cells and demonstrated the presence of damaged DNA in arsenite-arrested mitotic cells.	arsenite	30-38	granzyme H	Homo sapiens	80-85
15471901-5	2005	When synchronized CGL-2 cells were treated with arsenite at stage G1, S or G2, all progressed into, and arrested at, the mitotic stage and contained damaged DNA, as demonstrated by the appearance of the DNA double-strand break marker, phosphorylated histone H2A.X (gamma-H2AX).	arsenite	48-56	granzyme H	Homo sapiens	18-23
15471901-7	2005	However, treatment of X-irradiated CGL-2 cells with arsenite resulted in a decrease in G2 cells and an increase in mitotic cells, suggesting that arsenite may inhibit activation of the G2 DNA damage checkpoint and thus allow cells with damaged DNA to proceed from G2 into mitosis.	arsenite	52-60	granzyme H	Homo sapiens	35-40
15471901-7	2005	However, treatment of X-irradiated CGL-2 cells with arsenite resulted in a decrease in G2 cells and an increase in mitotic cells, suggesting that arsenite may inhibit activation of the G2 DNA damage checkpoint and thus allow cells with damaged DNA to proceed from G2 into mitosis.	arsenite	146-154	granzyme H	Homo sapiens	35-40
15471901-8	2005	Immunoblot analysis confirmed that arsenite treatment reduced the X-irradiation-induced phosphorylation of both ataxia-telangiectasia, mutated at serine 1981 and Cdc25C at serine 216, events which are crucial for G2 checkpoint activation and G2 arrest.	arsenite	35-43	cell division cycle 25C	Homo sapiens	162-168
15471901-9	2005	Moreover, a higher frequency of apoptotic cells is observed in mitotic CGL-2 cells arrested by arsenite than those arrested by nocodazole or taxol.	arsenite	95-103	granzyme H	Homo sapiens	71-76
15471901-10	2005	Our results show that the combined effects of arsenite in inducing DNA damages, inhibiting the activation of G2 checkpoint, and arresting cells with damaged DNA in the mitotic stage may subsequently enhance the induction of apoptosis in arsenite-arrested mitotic CGL-2 cells.	arsenite	46-54	granzyme H	Homo sapiens	263-268
15471901-10	2005	Our results show that the combined effects of arsenite in inducing DNA damages, inhibiting the activation of G2 checkpoint, and arresting cells with damaged DNA in the mitotic stage may subsequently enhance the induction of apoptosis in arsenite-arrested mitotic CGL-2 cells.	arsenite	237-245	granzyme H	Homo sapiens	263-268
16121039-0	2005	Arsenite regulates Cystic Fibrosis Transmembrane Conductance Regulator and P-glycoprotein: evidence of pathway independence.	arsenite	0-8	CF transmembrane conductance regulator	Homo sapiens	19-70
16121039-0	2005	Arsenite regulates Cystic Fibrosis Transmembrane Conductance Regulator and P-glycoprotein: evidence of pathway independence.	arsenite	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	75-89
16121039-5	2005	The goal of this study was to investigate the effects of trivalent arsenic (arsenite), a known transcriptional activator of Pgp, on CFTR expression.	arsenite	76-84	ATP binding cassette subfamily B member 1	Homo sapiens	124-127
16121039-5	2005	The goal of this study was to investigate the effects of trivalent arsenic (arsenite), a known transcriptional activator of Pgp, on CFTR expression.	arsenite	76-84	CF transmembrane conductance regulator	Homo sapiens	132-136
16121039-8	2005	CFTR expression was suppressed almost three-fold by arsenite, along with a concomitant increase in P-glycoprotein expression.	arsenite	52-60	CF transmembrane conductance regulator	Homo sapiens	0-4
16121039-9	2005	We also report that a member of the MAPK-family, the ERK-mediated signaling cascade is implicated in suppression of CFTR expression following treatment with arsenite.	arsenite	157-165	mitogen-activated protein kinase 1	Homo sapiens	36-40
16121039-9	2005	We also report that a member of the MAPK-family, the ERK-mediated signaling cascade is implicated in suppression of CFTR expression following treatment with arsenite.	arsenite	157-165	mitogen-activated protein kinase 1	Homo sapiens	53-56
16121039-9	2005	We also report that a member of the MAPK-family, the ERK-mediated signaling cascade is implicated in suppression of CFTR expression following treatment with arsenite.	arsenite	157-165	CF transmembrane conductance regulator	Homo sapiens	116-120
16121039-11	2005	Thus, the regulatory pathways that control functional expression of CFTR and P-glycoprotein following arsenite treatment in T-84 cells are distinct and independent.	arsenite	102-110	CF transmembrane conductance regulator	Homo sapiens	68-72
16121039-11	2005	Thus, the regulatory pathways that control functional expression of CFTR and P-glycoprotein following arsenite treatment in T-84 cells are distinct and independent.	arsenite	102-110	ATP binding cassette subfamily B member 1	Homo sapiens	77-91
15849723-7	2005	Arsenite, in a dose-dependent manner, induced generation of reactive oxygen species (ROS) and activation of early transcription factors such as nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) as shown by electro mobility shift assay.	arsenite	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	144-166
15849723-7	2005	Arsenite, in a dose-dependent manner, induced generation of reactive oxygen species (ROS) and activation of early transcription factors such as nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) as shown by electro mobility shift assay.	arsenite	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	168-177
15849723-7	2005	Arsenite, in a dose-dependent manner, induced generation of reactive oxygen species (ROS) and activation of early transcription factors such as nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) as shown by electro mobility shift assay.	arsenite	0-8	jun proto-oncogene	Mus musculus	183-202
15849723-7	2005	Arsenite, in a dose-dependent manner, induced generation of reactive oxygen species (ROS) and activation of early transcription factors such as nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) as shown by electro mobility shift assay.	arsenite	0-8	jun proto-oncogene	Mus musculus	204-208
15849723-9	2005	Arsenite at 1 microM concentration was sufficient for maximal activation of NF-kappaB and AP-1 activation.	arsenite	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	76-85
15849723-9	2005	Arsenite at 1 microM concentration was sufficient for maximal activation of NF-kappaB and AP-1 activation.	arsenite	0-8	jun proto-oncogene	Mus musculus	90-94
15849723-10	2005	Time kinetics studies showed maximal activation of NF-kappaB by 1 microM concentration of arsenite was seen at 120 min and correlated with complete degradation of Ikappa Balpha at 60 min.	arsenite	90-98	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	51-60
15849723-11	2005	Similarly, maximal activation of AP-1 by 1 microM concentration of arsenite occurred at 120 min.	arsenite	67-75	jun proto-oncogene	Mus musculus	33-37
15849723-12	2005	N-acetyl-L-cysteine at 50 microM concentration inhibited arsenite-induced NF-kappa B and AP-1.	arsenite	57-65	jun proto-oncogene	Mus musculus	89-93
15849723-13	2005	In addition, arsenite was shown to induce phosphorylation of extracellular signal regulated kinase (ERK) 1/2 at concentrations of 1 microM and above.	arsenite	13-21	mitogen-activated protein kinase 3	Mus musculus	61-108
15868481-4	2004	Arsenite induced the expression of HO1, HIF1alpha, KLF5, PPARgamma and C/EBPalpha.	arsenite	0-8	heme oxygenase 1	Mus musculus	35-38
15579417-6	2004	Cell lines derived from the tumors formed by injection of arsenite-exposed HaCaT cells into nude mice expressed higher levels of keratin 6, a proliferation marker of keratinocytes, than did parental HaCaT cells, whereas the expression of keratins 5, 8, and 10 was significantly decreased.	arsenite	58-66	keratin 6	Mus musculus	129-138
15611163-6	2004	We find that Hri2p is the primary activated eIF2 kinase in response to exposure to heat shock, arsenite, or cadmium.	arsenite	95-103	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	44-48
15371533-6	2004	Mouse embryomic fibroblasts (MEFs) lacking TIA-1 exhibit impaired ability to form SGs, although they exhibit normal phosphorylation of eukaryotic initiation factor (eIF)2alpha in response to arsenite.	arsenite	191-199	eukaryotic translation initiation factor 2A	Mus musculus	165-175
15504345-6	2004	The essential role of the p38 pathway in up-regulation of VDR expression was further confirmed by using the p38 stimulator arsenite.	arsenite	123-131	mitogen-activated protein kinase 1	Homo sapiens	26-29
15504345-6	2004	The essential role of the p38 pathway in up-regulation of VDR expression was further confirmed by using the p38 stimulator arsenite.	arsenite	123-131	vitamin D receptor	Homo sapiens	58-61
15504345-6	2004	The essential role of the p38 pathway in up-regulation of VDR expression was further confirmed by using the p38 stimulator arsenite.	arsenite	123-131	mitogen-activated protein kinase 1	Homo sapiens	108-111
15868481-4	2004	Arsenite induced the expression of HO1, HIF1alpha, KLF5, PPARgamma and C/EBPalpha.	arsenite	0-8	hypoxia inducible factor 1, alpha subunit	Mus musculus	40-49
15868481-4	2004	Arsenite induced the expression of HO1, HIF1alpha, KLF5, PPARgamma and C/EBPalpha.	arsenite	0-8	Kruppel-like factor 5	Mus musculus	51-55
15868481-4	2004	Arsenite induced the expression of HO1, HIF1alpha, KLF5, PPARgamma and C/EBPalpha.	arsenite	0-8	peroxisome proliferator activated receptor gamma	Mus musculus	57-66
15868481-4	2004	Arsenite induced the expression of HO1, HIF1alpha, KLF5, PPARgamma and C/EBPalpha.	arsenite	0-8	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	71-81
15451184-5	2004	In conclusion, cellular stress response induced by arsenite in BAE cells inhibited replication of BHV-4, and probably resulted from the induction of HSP70 and interference of cell cycle progression.	arsenite	51-59	heat shock protein family A (Hsp70) member 4	Homo sapiens	149-154
15504454-3	2004	In this study, we investigated activation of the extracellular signal regulated kinase (ERK) and the stress-associated kinase p38 by arsenite in HaCat cells, a spontaneously immortalized human keratinocyte cell line.	arsenite	133-141	mitogen-activated protein kinase 1	Homo sapiens	49-86
15504454-3	2004	In this study, we investigated activation of the extracellular signal regulated kinase (ERK) and the stress-associated kinase p38 by arsenite in HaCat cells, a spontaneously immortalized human keratinocyte cell line.	arsenite	133-141	mitogen-activated protein kinase 1	Homo sapiens	88-91
15504454-3	2004	In this study, we investigated activation of the extracellular signal regulated kinase (ERK) and the stress-associated kinase p38 by arsenite in HaCat cells, a spontaneously immortalized human keratinocyte cell line.	arsenite	133-141	mitogen-activated protein kinase 14	Homo sapiens	126-129
15504454-4	2004	Arsenite concentrations > or =100 microM stimulate rapid activation of p38 and ERK MAP kinases.	arsenite	0-8	mitogen-activated protein kinase 14	Homo sapiens	74-77
15504454-4	2004	Arsenite concentrations > or =100 microM stimulate rapid activation of p38 and ERK MAP kinases.	arsenite	0-8	mitogen-activated protein kinase 1	Homo sapiens	82-85
15504454-5	2004	However, upon extended exposure (24 h), persistent stimulation of p38 and ERK MAP kinases was detected at low micromolar concentrations of arsenite.	arsenite	139-147	mitogen-activated protein kinase 14	Homo sapiens	66-69
15504454-5	2004	However, upon extended exposure (24 h), persistent stimulation of p38 and ERK MAP kinases was detected at low micromolar concentrations of arsenite.	arsenite	139-147	mitogen-activated protein kinase 1	Homo sapiens	74-77
15504454-7	2004	ERK activation by arsenite was fully dependent on the catalytic activity of the epidermal growth factor (EGF) receptor and partially dependent on Src-family kinase activity.	arsenite	18-26	mitogen-activated protein kinase 1	Homo sapiens	0-3
15504454-7	2004	ERK activation by arsenite was fully dependent on the catalytic activity of the epidermal growth factor (EGF) receptor and partially dependent on Src-family kinase activity.	arsenite	18-26	epidermal growth factor receptor	Homo sapiens	80-118
15504454-9	2004	Arsenite-stimulated MAP kinase signal transduction resulted in increased production of matrix metalloproteinase (MMP)-9, an AP-1 regulated gene product.	arsenite	0-8	matrix metallopeptidase 9	Homo sapiens	87-119
15504454-10	2004	MMP-9 induction by arsenite was prevented when EGF receptor or MAP kinase signaling was inhibited.	arsenite	19-27	matrix metallopeptidase 9	Homo sapiens	0-5
15504454-10	2004	MMP-9 induction by arsenite was prevented when EGF receptor or MAP kinase signaling was inhibited.	arsenite	19-27	epidermal growth factor receptor	Homo sapiens	47-59
15504454-11	2004	These studies indicate that EGF receptor activation is a component of arsenite-mediated signal transduction and gene expression in keratinocytes and that low micromolar concentrations of arsenite stimulate key signaling pathways upon extended exposure.	arsenite	70-78	epidermal growth factor receptor	Homo sapiens	28-40
15486292-3	2004	Using molecular genetics, we show that the functional gene for As(V) respiration, arrA, is highly conserved; that it is required for As(V) reduction to arsenite when arsenic is sorbed onto iron minerals; and that it can be used to identify the presence and activity of As(V)-respiring bacteria in arsenic-contaminated iron-rich sediments.	arsenite	152-160	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	63-68
15486292-3	2004	Using molecular genetics, we show that the functional gene for As(V) respiration, arrA, is highly conserved; that it is required for As(V) reduction to arsenite when arsenic is sorbed onto iron minerals; and that it can be used to identify the presence and activity of As(V)-respiring bacteria in arsenic-contaminated iron-rich sediments.	arsenite	152-160	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	133-138
15486292-3	2004	Using molecular genetics, we show that the functional gene for As(V) respiration, arrA, is highly conserved; that it is required for As(V) reduction to arsenite when arsenic is sorbed onto iron minerals; and that it can be used to identify the presence and activity of As(V)-respiring bacteria in arsenic-contaminated iron-rich sediments.	arsenite	152-160	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	133-138
15337587-0	2004	Modulation of aryl hydrocarbon receptor-regulated gene expression by arsenite, cadmium, and chromium.	arsenite	69-77	aryl-hydrocarbon receptor	Mus musculus	14-39
15276411-8	2004	Our studies with recombinant rat cyt19 find that, in the presence of an exogenous or a physiological reductant, this protein can catalyze the entire sequence of reactions that convert arsenite to methylated metabolites.	arsenite	184-192	arsenite methyltransferase	Rattus norvegicus	33-38
15327774-5	2004	Arsenite, but not heat shock, requires signaling via p38 MAP kinase for Hsp70 induction and histone H3 phosphorylation.	arsenite	0-8	mitogen-activated protein kinase 14	Homo sapiens	53-56
15327774-5	2004	Arsenite, but not heat shock, requires signaling via p38 MAP kinase for Hsp70 induction and histone H3 phosphorylation.	arsenite	0-8	heat shock protein family A (Hsp70) member 4	Homo sapiens	72-77
15292961-0	2004	The zinc finger transcription factor Egr-1 is upregulated in arsenite-treated human keratinocytes.	arsenite	61-69	early growth response 1	Homo sapiens	37-42
15292961-3	2004	In particular, the activation of the stress-induced protein kinase c-Jun N-terminal protein kinase and p38 and the phosphorylation and activation of the transcription factor c-Jun have been linked to the biological effects of arsenite.	arsenite	226-234	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	67-72
15292961-3	2004	In particular, the activation of the stress-induced protein kinase c-Jun N-terminal protein kinase and p38 and the phosphorylation and activation of the transcription factor c-Jun have been linked to the biological effects of arsenite.	arsenite	226-234	mitogen-activated protein kinase 14	Homo sapiens	103-106
15292961-3	2004	In particular, the activation of the stress-induced protein kinase c-Jun N-terminal protein kinase and p38 and the phosphorylation and activation of the transcription factor c-Jun have been linked to the biological effects of arsenite.	arsenite	226-234	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	174-179
15292961-4	2004	We analyzed whether arsenite has an impact on the biosynthesis of the zinc finger transcription factor Egr-1.	arsenite	20-28	early growth response 1	Homo sapiens	103-108
15292961-6	2004	Here, we show by Western blot experiments that arsenite induces a transient synthesis of Egr-1 in human HaCaT keratinocytes.	arsenite	47-55	early growth response 1	Homo sapiens	89-94
15292961-7	2004	Egr-1 biosynthesis was activated by arsenite concentrations insufficient for the induction of c-Jun biosynthesis.	arsenite	36-44	early growth response 1	Homo sapiens	0-5
15292961-8	2004	This arsenite-triggered Egr-1 biosynthesis was completely inhibited by the mitogen-activated protein kinase kinase inhibitor PD98059 and by AG1487, an epidermal growth factor (EGF) receptor-specific tyrosine kinase inhibitor.	arsenite	5-13	early growth response 1	Homo sapiens	24-29
15292961-8	2004	This arsenite-triggered Egr-1 biosynthesis was completely inhibited by the mitogen-activated protein kinase kinase inhibitor PD98059 and by AG1487, an epidermal growth factor (EGF) receptor-specific tyrosine kinase inhibitor.	arsenite	5-13	epidermal growth factor receptor	Homo sapiens	151-189
15292961-9	2004	These results indicate that activation of the EGF receptor as well as stimulation of the mitogen activated/extracellular signal-regulated protein kinase is essential for arsenite-induced upregulation of Egr-1.	arsenite	170-178	epidermal growth factor receptor	Homo sapiens	46-58
15292961-9	2004	These results indicate that activation of the EGF receptor as well as stimulation of the mitogen activated/extracellular signal-regulated protein kinase is essential for arsenite-induced upregulation of Egr-1.	arsenite	170-178	early growth response 1	Homo sapiens	203-208
15292961-12	2004	Accordingly, we observed an increase in Egr-1 promoter activity as a result of arsenite treatment.	arsenite	79-87	early growth response 1	Homo sapiens	40-45
15292961-13	2004	The fact that low concentrations of arsenite are sufficient to induce Egr-1 biosynthesis suggests that Egr-1 may be an integral part of arsenite-triggered signaling cascades leading to tumor formation or cell death via alterations of the cellular genetic program.	arsenite	36-44	early growth response 1	Homo sapiens	70-75
15292961-13	2004	The fact that low concentrations of arsenite are sufficient to induce Egr-1 biosynthesis suggests that Egr-1 may be an integral part of arsenite-triggered signaling cascades leading to tumor formation or cell death via alterations of the cellular genetic program.	arsenite	36-44	early growth response 1	Homo sapiens	103-108
15292961-13	2004	The fact that low concentrations of arsenite are sufficient to induce Egr-1 biosynthesis suggests that Egr-1 may be an integral part of arsenite-triggered signaling cascades leading to tumor formation or cell death via alterations of the cellular genetic program.	arsenite	136-144	early growth response 1	Homo sapiens	70-75
15292961-13	2004	The fact that low concentrations of arsenite are sufficient to induce Egr-1 biosynthesis suggests that Egr-1 may be an integral part of arsenite-triggered signaling cascades leading to tumor formation or cell death via alterations of the cellular genetic program.	arsenite	136-144	early growth response 1	Homo sapiens	103-108
15355704-0	2004	[Toxic effect of arsenite on the expression of liver multidrug resistance-associated protein 2 in rat].	arsenite	17-25	ATP binding cassette subfamily C member 2	Rattus norvegicus	53-94
15355704-8	2004	CONCLUSIONS: Bile is one of the major routes for the excretion of arsenite and its metabolites, and the overexpression of MRP2 may play an important role in the bile excretion of them at early stage.	arsenite	66-74	ATP binding cassette subfamily C member 2	Rattus norvegicus	122-126
15276423-5	2004	In contrast, trivalent arsenicals, arsenite (iAs(III)), methylarsine oxide (MAs(III)O), and iododimethylarsine (DMAs(III)O) inhibited insulin-stimulated glucose uptake in a concentration-dependent manner.	arsenite	35-43	insulin	Homo sapiens	134-141
15147840-2	2004	ArsC catalyses the reduction of arsenate to arsenite.	arsenite	44-52	arsenate reductase	Staphylococcus aureus	0-4
15153785-5	2004	Treatment of BHV-4-infected BAE cells with either U0126, a potent inhibitor of MAPK/ERK kinase, or arsenite dose-dependently blocked ERK activation and inhibited viral DNA synthesis and viral replication in the culture.	arsenite	99-107	mitogen-activated protein kinase 1	Homo sapiens	133-136
15161912-5	2004	Using membrane vesicles prepared from the MRP1-overexpressing lung cancer cell line, H69AR, we found that MRP1 transports arsenite (As(III)) only in the presence of GSH but does not transport arsenate (As(V)) (with or without GSH).	arsenite	122-130	ATP binding cassette subfamily C member 1	Homo sapiens	42-46
15161912-5	2004	Using membrane vesicles prepared from the MRP1-overexpressing lung cancer cell line, H69AR, we found that MRP1 transports arsenite (As(III)) only in the presence of GSH but does not transport arsenate (As(V)) (with or without GSH).	arsenite	122-130	ATP binding cassette subfamily C member 1	Homo sapiens	106-110
15163543-5	2004	On the other hand, arsenite has high affinity for sulfhydryl groups and thus can form covalent bonds with the disulfide bridges in the molecules of insulin, insulin receptors, glucose transporters (GLUTs), and enzymes involved in glucose metabolism (e.g., pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase).	arsenite	19-27	insulin	Homo sapiens	148-155
15056798-4	2004	Our results demonstrate that arsenite (0.005-5 microM) elevates COX-2 expression, PGE(2) secretion (2.5-5 microM), and DNA synthesis (1-5 microM).	arsenite	29-37	prostaglandin-endoperoxide synthase 2	Homo sapiens	64-69
15056798-5	2004	Arsenite stimulated p42/44 but not p38 MAPK phosphorylation (2.5 microM), responses different than those produced by epidermal growth factor.	arsenite	0-8	cyclin dependent kinase 20	Homo sapiens	20-23
15056798-6	2004	Inhibition of mitogen-activated protein kinase kinase (MAPKK) and p38 MAPK using PD98059 (20 microM) and SB202190 (5 microM), respectively, attenuated the elevation of COX-2 protein induced by arsenite, whereas physiological concentrations of three COX-2 inhibitors (e.g., NS-398, piroxicam, and aspirin) reduced arsenite-stimulated DNA synthesis.	arsenite	193-201	mitogen-activated protein kinase 14	Homo sapiens	66-69
15056798-6	2004	Inhibition of mitogen-activated protein kinase kinase (MAPKK) and p38 MAPK using PD98059 (20 microM) and SB202190 (5 microM), respectively, attenuated the elevation of COX-2 protein induced by arsenite, whereas physiological concentrations of three COX-2 inhibitors (e.g., NS-398, piroxicam, and aspirin) reduced arsenite-stimulated DNA synthesis.	arsenite	193-201	prostaglandin-endoperoxide synthase 2	Homo sapiens	168-173
15056798-6	2004	Inhibition of mitogen-activated protein kinase kinase (MAPKK) and p38 MAPK using PD98059 (20 microM) and SB202190 (5 microM), respectively, attenuated the elevation of COX-2 protein induced by arsenite, whereas physiological concentrations of three COX-2 inhibitors (e.g., NS-398, piroxicam, and aspirin) reduced arsenite-stimulated DNA synthesis.	arsenite	193-201	prostaglandin-endoperoxide synthase 2	Homo sapiens	249-254
15056798-6	2004	Inhibition of mitogen-activated protein kinase kinase (MAPKK) and p38 MAPK using PD98059 (20 microM) and SB202190 (5 microM), respectively, attenuated the elevation of COX-2 protein induced by arsenite, whereas physiological concentrations of three COX-2 inhibitors (e.g., NS-398, piroxicam, and aspirin) reduced arsenite-stimulated DNA synthesis.	arsenite	313-321	mitogen-activated protein kinase 14	Homo sapiens	66-69
15056798-6	2004	Inhibition of mitogen-activated protein kinase kinase (MAPKK) and p38 MAPK using PD98059 (20 microM) and SB202190 (5 microM), respectively, attenuated the elevation of COX-2 protein induced by arsenite, whereas physiological concentrations of three COX-2 inhibitors (e.g., NS-398, piroxicam, and aspirin) reduced arsenite-stimulated DNA synthesis.	arsenite	313-321	prostaglandin-endoperoxide synthase 2	Homo sapiens	168-173
15056798-7	2004	These data indicate that arsenite elevates COX-2 in NHEK at the transcriptional and translational levels as well as increases PGE(2) secretion.	arsenite	25-33	prostaglandin-endoperoxide synthase 2	Homo sapiens	43-48
15028728-0	2004	Arsenite sensitizes human melanomas to apoptosis via tumor necrosis factor alpha-mediated pathway.	arsenite	0-8	tumor necrosis factor	Homo sapiens	53-80
15028728-4	2004	The two prerequisites that dictate apoptotic response of melanomas upon arsenite treatment are low nuclear NF-kappaB activity and an endogenous expression of tumor necrosis factor alpha.	arsenite	72-80	tumor necrosis factor	Homo sapiens	158-185
15028728-6	2004	On the other hand, signaling pathways including those of phosphatidylinositol 3-kinase-AKT, MEK-ERK, and JNK play a protective role against arsenite-induced oxidative stress and apoptosis in melanoma cells.	arsenite	140-148	AKT serine/threonine kinase 1	Homo sapiens	87-90
15028728-6	2004	On the other hand, signaling pathways including those of phosphatidylinositol 3-kinase-AKT, MEK-ERK, and JNK play a protective role against arsenite-induced oxidative stress and apoptosis in melanoma cells.	arsenite	140-148	mitogen-activated protein kinase kinase 7	Homo sapiens	92-95
15028728-6	2004	On the other hand, signaling pathways including those of phosphatidylinositol 3-kinase-AKT, MEK-ERK, and JNK play a protective role against arsenite-induced oxidative stress and apoptosis in melanoma cells.	arsenite	140-148	mitogen-activated protein kinase 1	Homo sapiens	96-99
15028728-6	2004	On the other hand, signaling pathways including those of phosphatidylinositol 3-kinase-AKT, MEK-ERK, and JNK play a protective role against arsenite-induced oxidative stress and apoptosis in melanoma cells.	arsenite	140-148	mitogen-activated protein kinase 8	Homo sapiens	105-108
14729728-8	2004	The chemical stressors anisomycin and arsenite each increased the levels of HSP27 phosphorylation and, at the same time, decreased bead motions.	arsenite	38-46	heat shock protein family B (small) member 1	Homo sapiens	76-81
14729728-10	2004	Finally, ASM cells overexpressing phospho-mimicking human HSP27, but not wild-type or phosphorylation-deficient HSP27, exhibited decreases in bead motions that were comparable to the arsenite response.	arsenite	183-191	heat shock protein family B (small) member 1	Homo sapiens	58-63
14966117-3	2004	In the absence of glucose, strains with disruption of the arsenite efflux gene ACR3 accumulated high levels of (73)As(OH)(3).	arsenite	58-66	Arr3p	Saccharomyces cerevisiae S288C	79-83
15014438-4	2004	Exclusion of TTP from arsenite-induced SGs is a consequence of MAPKAP kinase-2 (MK2)-induced phosphorylation at serines 52 and 178, which promotes the assembly of TTP:14-3-3 complexes.	arsenite	22-30	ZFP36 ring finger protein	Homo sapiens	13-16
15014438-4	2004	Exclusion of TTP from arsenite-induced SGs is a consequence of MAPKAP kinase-2 (MK2)-induced phosphorylation at serines 52 and 178, which promotes the assembly of TTP:14-3-3 complexes.	arsenite	22-30	MAPK activated protein kinase 2	Homo sapiens	63-78
15014438-4	2004	Exclusion of TTP from arsenite-induced SGs is a consequence of MAPKAP kinase-2 (MK2)-induced phosphorylation at serines 52 and 178, which promotes the assembly of TTP:14-3-3 complexes.	arsenite	22-30	MAPK activated protein kinase 2	Homo sapiens	80-83
15014438-4	2004	Exclusion of TTP from arsenite-induced SGs is a consequence of MAPKAP kinase-2 (MK2)-induced phosphorylation at serines 52 and 178, which promotes the assembly of TTP:14-3-3 complexes.	arsenite	22-30	ZFP36 ring finger protein	Homo sapiens	163-166
15163543-12	2004	Arsenite at physiologically relevant concentration also shows inhibitory effect on the expression of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear hormone receptor important for activating insulin action.	arsenite	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	101-149
15163543-12	2004	Arsenite at physiologically relevant concentration also shows inhibitory effect on the expression of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear hormone receptor important for activating insulin action.	arsenite	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	151-160
15163543-12	2004	Arsenite at physiologically relevant concentration also shows inhibitory effect on the expression of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear hormone receptor important for activating insulin action.	arsenite	0-8	insulin	Homo sapiens	215-222
15163543-5	2004	On the other hand, arsenite has high affinity for sulfhydryl groups and thus can form covalent bonds with the disulfide bridges in the molecules of insulin, insulin receptors, glucose transporters (GLUTs), and enzymes involved in glucose metabolism (e.g., pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase).	arsenite	19-27	insulin	Homo sapiens	157-164
14967008-2	2004	Exposure of PAECs to l-buthionine sulfoximine (BSO), an inhibitor of gamma-glutamylcysteine synthetase (gamma-GCS), markedly enhanced the arsenite-induced cytotoxicity.	arsenite	138-146	glutamate-cysteine ligase catalytic subunit	Homo sapiens	69-102
15037631-6	2004	p38 activation by both adenovirus-mediated gene delivery of constitutively active p38 activator MKK6 and by arsenite selectively induces cell death in K-ras-activated human colon cancer HCT116 cells but not in the K-ras-disrupted HCT116-derived sublines.	arsenite	108-116	mitogen-activated protein kinase 14	Homo sapiens	0-3
15037631-6	2004	p38 activation by both adenovirus-mediated gene delivery of constitutively active p38 activator MKK6 and by arsenite selectively induces cell death in K-ras-activated human colon cancer HCT116 cells but not in the K-ras-disrupted HCT116-derived sublines.	arsenite	108-116	KRAS proto-oncogene, GTPase	Homo sapiens	151-156
15037631-9	2004	Forced VDR expression in K-ras-activated cells inhibits p38 activation-induced cell death, and inhibition of endogenous VDR protein expression in K-ras-disrupted cells increased the arsenite-induced toxicity.	arsenite	182-190	vitamin D receptor	Homo sapiens	120-123
15037631-9	2004	Forced VDR expression in K-ras-activated cells inhibits p38 activation-induced cell death, and inhibition of endogenous VDR protein expression in K-ras-disrupted cells increased the arsenite-induced toxicity.	arsenite	182-190	KRAS proto-oncogene, GTPase	Homo sapiens	146-151
14967008-2	2004	Exposure of PAECs to l-buthionine sulfoximine (BSO), an inhibitor of gamma-glutamylcysteine synthetase (gamma-GCS), markedly enhanced the arsenite-induced cytotoxicity.	arsenite	138-146	glutamate-cysteine ligase catalytic subunit	Homo sapiens	104-113
14967008-8	2004	Moreover, exposure of PAECs to NAC alleviated the arsenite-induced JNK/AP-1 activation and apoptosis, whereas exposure of PAECs to BSO enhanced the arsenite-induced JNK/AP-1 activation and apoptosis.	arsenite	50-58	mitogen-activated protein kinase 8	Homo sapiens	67-70
14967008-8	2004	Moreover, exposure of PAECs to NAC alleviated the arsenite-induced JNK/AP-1 activation and apoptosis, whereas exposure of PAECs to BSO enhanced the arsenite-induced JNK/AP-1 activation and apoptosis.	arsenite	148-156	mitogen-activated protein kinase 8	Homo sapiens	165-168
14514659-4	2004	Our results indicate a molecular mechanism by which MAPK pathways might differentially contribute to cell growth regulation and cell death in response to different dosages of arsenite.	arsenite	175-183	mitogen-activated protein kinase 1	Homo sapiens	52-56
14514659-5	2004	A low level (2 micro M) of arsenite stimulated extracellular signal-regulated kinase (ERK) signaling pathway and enhanced cell proliferation, and this arsenite-induced ERK activity was blocked by MEK inhibitor, PD98059.	arsenite	27-35	mitogen-activated protein kinase 1	Homo sapiens	47-84
14514659-5	2004	A low level (2 micro M) of arsenite stimulated extracellular signal-regulated kinase (ERK) signaling pathway and enhanced cell proliferation, and this arsenite-induced ERK activity was blocked by MEK inhibitor, PD98059.	arsenite	27-35	mitogen-activated protein kinase 1	Homo sapiens	86-89
14514659-5	2004	A low level (2 micro M) of arsenite stimulated extracellular signal-regulated kinase (ERK) signaling pathway and enhanced cell proliferation, and this arsenite-induced ERK activity was blocked by MEK inhibitor, PD98059.	arsenite	27-35	mitogen-activated protein kinase 1	Homo sapiens	168-171
14514659-5	2004	A low level (2 micro M) of arsenite stimulated extracellular signal-regulated kinase (ERK) signaling pathway and enhanced cell proliferation, and this arsenite-induced ERK activity was blocked by MEK inhibitor, PD98059.	arsenite	27-35	mitogen-activated protein kinase kinase 7	Homo sapiens	196-199
14514659-5	2004	A low level (2 micro M) of arsenite stimulated extracellular signal-regulated kinase (ERK) signaling pathway and enhanced cell proliferation, and this arsenite-induced ERK activity was blocked by MEK inhibitor, PD98059.	arsenite	151-159	mitogen-activated protein kinase 1	Homo sapiens	47-84
14514659-5	2004	A low level (2 micro M) of arsenite stimulated extracellular signal-regulated kinase (ERK) signaling pathway and enhanced cell proliferation, and this arsenite-induced ERK activity was blocked by MEK inhibitor, PD98059.	arsenite	151-159	mitogen-activated protein kinase 1	Homo sapiens	86-89
14514659-5	2004	A low level (2 micro M) of arsenite stimulated extracellular signal-regulated kinase (ERK) signaling pathway and enhanced cell proliferation, and this arsenite-induced ERK activity was blocked by MEK inhibitor, PD98059.	arsenite	151-159	mitogen-activated protein kinase 1	Homo sapiens	168-171
14514659-5	2004	A low level (2 micro M) of arsenite stimulated extracellular signal-regulated kinase (ERK) signaling pathway and enhanced cell proliferation, and this arsenite-induced ERK activity was blocked by MEK inhibitor, PD98059.	arsenite	151-159	mitogen-activated protein kinase kinase 7	Homo sapiens	196-199
14514659-6	2004	In contrast, a high level (40 micro M) of arsenite stimulated the c-Jun N-terminal kinase (JNK) signaling pathway and induced cell apoptosis, and this arsenite-induced JNK activity was blocked by JNK inhibitor II, SP600125.	arsenite	42-50	mitogen-activated protein kinase 8	Homo sapiens	66-89
14514659-6	2004	In contrast, a high level (40 micro M) of arsenite stimulated the c-Jun N-terminal kinase (JNK) signaling pathway and induced cell apoptosis, and this arsenite-induced JNK activity was blocked by JNK inhibitor II, SP600125.	arsenite	42-50	mitogen-activated protein kinase 8	Homo sapiens	91-94
14514659-6	2004	In contrast, a high level (40 micro M) of arsenite stimulated the c-Jun N-terminal kinase (JNK) signaling pathway and induced cell apoptosis, and this arsenite-induced JNK activity was blocked by JNK inhibitor II, SP600125.	arsenite	42-50	mitogen-activated protein kinase 8	Homo sapiens	168-171
14514659-6	2004	In contrast, a high level (40 micro M) of arsenite stimulated the c-Jun N-terminal kinase (JNK) signaling pathway and induced cell apoptosis, and this arsenite-induced JNK activity was blocked by JNK inhibitor II, SP600125.	arsenite	42-50	mitogen-activated protein kinase 8	Homo sapiens	168-171
14514659-6	2004	In contrast, a high level (40 micro M) of arsenite stimulated the c-Jun N-terminal kinase (JNK) signaling pathway and induced cell apoptosis, and this arsenite-induced JNK activity was blocked by JNK inhibitor II, SP600125.	arsenite	151-159	mitogen-activated protein kinase 8	Homo sapiens	66-89
14514659-6	2004	In contrast, a high level (40 micro M) of arsenite stimulated the c-Jun N-terminal kinase (JNK) signaling pathway and induced cell apoptosis, and this arsenite-induced JNK activity was blocked by JNK inhibitor II, SP600125.	arsenite	151-159	mitogen-activated protein kinase 8	Homo sapiens	91-94
14514659-6	2004	In contrast, a high level (40 micro M) of arsenite stimulated the c-Jun N-terminal kinase (JNK) signaling pathway and induced cell apoptosis, and this arsenite-induced JNK activity was blocked by JNK inhibitor II, SP600125.	arsenite	151-159	mitogen-activated protein kinase 8	Homo sapiens	168-171
14514659-6	2004	In contrast, a high level (40 micro M) of arsenite stimulated the c-Jun N-terminal kinase (JNK) signaling pathway and induced cell apoptosis, and this arsenite-induced JNK activity was blocked by JNK inhibitor II, SP600125.	arsenite	151-159	mitogen-activated protein kinase 8	Homo sapiens	168-171
12881212-3	2003	Adult rat ventricular myocytes treated with 1 mM arsenite for 30 min had a 16-fold increase in p38 MAPK phosphorylation that was attenuated by SB-203580 (a p38 MAPK inhibitor).	arsenite	49-57	mitogen activated protein kinase 14	Rattus norvegicus	95-98
14971642-0	2004	Arsenite induces p70S6K1 activation and HIF-1alpha expression in prostate cancer cells.	arsenite	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-50
14971642-6	2004	In this study we demonstrated that arsenite treatment increased levels of p70S6K1 phosphorylation and p70S6K1 activity in a PI3K and mTOR sensitive manner.	arsenite	35-43	mechanistic target of rapamycin kinase	Homo sapiens	133-137
14971642-7	2004	We have also shown that arsenite specifically induces HIF-1alpha, but not HIF-1beta, protein levels in prostate cancer cells in a mTOR-dependent manner.	arsenite	24-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	54-64
14971642-7	2004	We have also shown that arsenite specifically induces HIF-1alpha, but not HIF-1beta, protein levels in prostate cancer cells in a mTOR-dependent manner.	arsenite	24-32	mechanistic target of rapamycin kinase	Homo sapiens	130-134
14971644-0	2004	Arsenite induces HIF-1alpha and VEGF through PI3K, Akt and reactive oxygen species in DU145 human prostate carcinoma cells.	arsenite	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-27
14971644-0	2004	Arsenite induces HIF-1alpha and VEGF through PI3K, Akt and reactive oxygen species in DU145 human prostate carcinoma cells.	arsenite	0-8	vascular endothelial growth factor A	Homo sapiens	32-36
14971644-0	2004	Arsenite induces HIF-1alpha and VEGF through PI3K, Akt and reactive oxygen species in DU145 human prostate carcinoma cells.	arsenite	0-8	AKT serine/threonine kinase 1	Homo sapiens	51-54
14971644-3	2004	In this study, we investigated whether arsenite induces expression of hypoxia-inducible factor 1 (HIF-1).	arsenite	39-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-96
14971644-3	2004	In this study, we investigated whether arsenite induces expression of hypoxia-inducible factor 1 (HIF-1).	arsenite	39-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	98-103
14971644-5	2004	Here we demonstrate that arsenite induces the expression of HIF-1alpha but not HIF-1beta subunit in DU145 human prostate carcinoma cells.	arsenite	25-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	60-70
14971644-6	2004	Arsenite also increases the expression of VEGF through the induction of HIF-1.	arsenite	0-8	vascular endothelial growth factor A	Homo sapiens	42-46
14971644-6	2004	Arsenite also increases the expression of VEGF through the induction of HIF-1.	arsenite	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	72-77
14971644-7	2004	We also found that arsenite activates PI3K and Akt that are required for arsenite-induced expression of HIF-1alpha and VEGF.	arsenite	19-27	AKT serine/threonine kinase 1	Homo sapiens	47-50
14971644-7	2004	We also found that arsenite activates PI3K and Akt that are required for arsenite-induced expression of HIF-1alpha and VEGF.	arsenite	19-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	104-114
14971644-7	2004	We also found that arsenite activates PI3K and Akt that are required for arsenite-induced expression of HIF-1alpha and VEGF.	arsenite	19-27	vascular endothelial growth factor A	Homo sapiens	119-123
14971644-7	2004	We also found that arsenite activates PI3K and Akt that are required for arsenite-induced expression of HIF-1alpha and VEGF.	arsenite	73-81	AKT serine/threonine kinase 1	Homo sapiens	47-50
14971644-7	2004	We also found that arsenite activates PI3K and Akt that are required for arsenite-induced expression of HIF-1alpha and VEGF.	arsenite	73-81	hypoxia inducible factor 1 subunit alpha	Homo sapiens	104-114
14971644-7	2004	We also found that arsenite activates PI3K and Akt that are required for arsenite-induced expression of HIF-1alpha and VEGF.	arsenite	73-81	vascular endothelial growth factor A	Homo sapiens	119-123
14971644-8	2004	The induction of HIF-1 and VEGF by arsenite can not be inhibited by MAP kinase inhibitors.	arsenite	35-43	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-22
14971644-8	2004	The induction of HIF-1 and VEGF by arsenite can not be inhibited by MAP kinase inhibitors.	arsenite	35-43	vascular endothelial growth factor A	Homo sapiens	27-31
14971644-11	2004	These data indicate that the arsenite-induced activation of PI3K/Akt signaling and the expression of HIF-1 and VEGF through the generation of ROS could be an important mechanism in the arsenite-induced carcinogenesis.	arsenite	29-37	AKT serine/threonine kinase 1	Homo sapiens	65-68
14971644-11	2004	These data indicate that the arsenite-induced activation of PI3K/Akt signaling and the expression of HIF-1 and VEGF through the generation of ROS could be an important mechanism in the arsenite-induced carcinogenesis.	arsenite	29-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	101-106
14971644-11	2004	These data indicate that the arsenite-induced activation of PI3K/Akt signaling and the expression of HIF-1 and VEGF through the generation of ROS could be an important mechanism in the arsenite-induced carcinogenesis.	arsenite	29-37	vascular endothelial growth factor A	Homo sapiens	111-115
14971644-11	2004	These data indicate that the arsenite-induced activation of PI3K/Akt signaling and the expression of HIF-1 and VEGF through the generation of ROS could be an important mechanism in the arsenite-induced carcinogenesis.	arsenite	185-193	AKT serine/threonine kinase 1	Homo sapiens	65-68
14971644-11	2004	These data indicate that the arsenite-induced activation of PI3K/Akt signaling and the expression of HIF-1 and VEGF through the generation of ROS could be an important mechanism in the arsenite-induced carcinogenesis.	arsenite	185-193	hypoxia inducible factor 1 subunit alpha	Homo sapiens	101-106
14971644-11	2004	These data indicate that the arsenite-induced activation of PI3K/Akt signaling and the expression of HIF-1 and VEGF through the generation of ROS could be an important mechanism in the arsenite-induced carcinogenesis.	arsenite	185-193	vascular endothelial growth factor A	Homo sapiens	111-115
12881212-3	2003	Adult rat ventricular myocytes treated with 1 mM arsenite for 30 min had a 16-fold increase in p38 MAPK phosphorylation that was attenuated by SB-203580 (a p38 MAPK inhibitor).	arsenite	49-57	mitogen activated protein kinase 14	Rattus norvegicus	156-159
12881212-5	2003	In addition, arsenite caused a p38 MAPK-independent translocation/activation of protein phosphatase 2a (PP2a) and decrease in phosphorylation of myosin light chain 2 (LC2).	arsenite	13-21	mitogen activated protein kinase 14	Rattus norvegicus	31-34
12881212-5	2003	In addition, arsenite caused a p38 MAPK-independent translocation/activation of protein phosphatase 2a (PP2a) and decrease in phosphorylation of myosin light chain 2 (LC2).	arsenite	13-21	myosin light chain 2	Rattus norvegicus	145-165
12881212-6	2003	Arsenite-p38 MAPK activation led to translocation of heat shock protein 27 but not alpha B-crystallin to the myofilaments.	arsenite	0-8	mitogen activated protein kinase 14	Rattus norvegicus	9-12
12881212-7	2003	Using isolated cardiomyocytes, we determined that arsenite reduces isometric tension without a change in Ca2+ sensitivity of tension via p38 MAPK and lowers myofibrillar actomyosin Mg2+-ATPase activity in a p38 MAPK-independent manner.	arsenite	50-58	mitogen activated protein kinase 14	Rattus norvegicus	207-210
12881212-8	2003	Thus arsenite induces a p38 MAPK-independent change in PP2a and LC2 that may account for the arsenite-dependent decrease in ATPase and a p38 MAPK-dependent modification of the myofilaments that decreases myocardial force development.	arsenite	5-13	mitogen activated protein kinase 14	Rattus norvegicus	24-27
12881212-8	2003	Thus arsenite induces a p38 MAPK-independent change in PP2a and LC2 that may account for the arsenite-dependent decrease in ATPase and a p38 MAPK-dependent modification of the myofilaments that decreases myocardial force development.	arsenite	5-13	mitogen activated protein kinase 14	Rattus norvegicus	137-140
12881212-8	2003	Thus arsenite induces a p38 MAPK-independent change in PP2a and LC2 that may account for the arsenite-dependent decrease in ATPase and a p38 MAPK-dependent modification of the myofilaments that decreases myocardial force development.	arsenite	93-101	mitogen activated protein kinase 14	Rattus norvegicus	24-27
14599775-6	2003	Also, Fpg and XPA involved in BER and NER, respectively, are inactivated by arsenite, MMA(III) and DMA(III).	arsenite	76-84	XPA, DNA damage recognition and repair factor	Homo sapiens	14-17
14674888-0	2003	Arsenite and arsenate activate extracellular signal-regulated kinases 1/2 by an epidermal growth factor receptor-mediated pathway in normal human keratinocytes.	arsenite	0-8	mitogen-activated protein kinase 1	Homo sapiens	31-73
14674888-0	2003	Arsenite and arsenate activate extracellular signal-regulated kinases 1/2 by an epidermal growth factor receptor-mediated pathway in normal human keratinocytes.	arsenite	0-8	epidermal growth factor receptor	Homo sapiens	80-112
14674888-16	2003	CONCLUSIONS: Our data indicate that both arsenite and arsenate activate the EGFR-Shc-Grb2-MEK1/2-ERK1/2 signalling cascade in NHEK.	arsenite	41-49	epidermal growth factor receptor	Homo sapiens	76-80
14674888-16	2003	CONCLUSIONS: Our data indicate that both arsenite and arsenate activate the EGFR-Shc-Grb2-MEK1/2-ERK1/2 signalling cascade in NHEK.	arsenite	41-49	SHC adaptor protein 1	Homo sapiens	81-84
14674888-16	2003	CONCLUSIONS: Our data indicate that both arsenite and arsenate activate the EGFR-Shc-Grb2-MEK1/2-ERK1/2 signalling cascade in NHEK.	arsenite	41-49	growth factor receptor bound protein 2	Homo sapiens	85-89
14674888-16	2003	CONCLUSIONS: Our data indicate that both arsenite and arsenate activate the EGFR-Shc-Grb2-MEK1/2-ERK1/2 signalling cascade in NHEK.	arsenite	41-49	mitogen-activated protein kinase kinase 1	Homo sapiens	90-96
14674888-16	2003	CONCLUSIONS: Our data indicate that both arsenite and arsenate activate the EGFR-Shc-Grb2-MEK1/2-ERK1/2 signalling cascade in NHEK.	arsenite	41-49	mitogen-activated protein kinase 3	Homo sapiens	97-103
14592461-4	2003	Treatment of FGF-1 with ONOO(-) induced a dose-dependent (10-50 microM) loss of sulfhydryl groups that correlated with formation of reducible (dithiothreitol, arsenite) FGF-1 aggregates containing 50% latent biologic activity.	arsenite	159-167	fibroblast growth factor 1	Homo sapiens	13-18
14592461-4	2003	Treatment of FGF-1 with ONOO(-) induced a dose-dependent (10-50 microM) loss of sulfhydryl groups that correlated with formation of reducible (dithiothreitol, arsenite) FGF-1 aggregates containing 50% latent biologic activity.	arsenite	159-167	fibroblast growth factor 1	Homo sapiens	169-174
14516795-0	2003	Hydrogen peroxide mediates arsenite activation of p70(s6k) and extracellular signal-regulated kinase.	arsenite	27-35	ribosomal protein S6 kinase B1	Homo sapiens	50-57
14560018-6	2003	In contrast to MK2, which shows interaction with and chaperoning properties for p38 MAPK and which is activated by extracellular stresses such as arsenite or sorbitol treatment, endogenous MK5 did not show these properties.	arsenite	146-154	MAP kinase-activated protein kinase 2	Mus musculus	15-18
14516795-8	2003	DNA binding activity of AP-1, downstream of ERK1/2, was also inhibited by catalase, N-acetyl-L-cysteine, and the MEK inhibitor PD98059, which significantly blocked arsenite activation of ERK1/2.	arsenite	164-172	mitogen-activated protein kinase 3	Homo sapiens	44-50
14516795-8	2003	DNA binding activity of AP-1, downstream of ERK1/2, was also inhibited by catalase, N-acetyl-L-cysteine, and the MEK inhibitor PD98059, which significantly blocked arsenite activation of ERK1/2.	arsenite	164-172	mitogen-activated protein kinase kinase 7	Homo sapiens	113-116
14516795-8	2003	DNA binding activity of AP-1, downstream of ERK1/2, was also inhibited by catalase, N-acetyl-L-cysteine, and the MEK inhibitor PD98059, which significantly blocked arsenite activation of ERK1/2.	arsenite	164-172	mitogen-activated protein kinase 3	Homo sapiens	187-193
14516795-9	2003	Taken together, these studies provide insight into mechanisms of arsenite-induced tumor promotion and suggest that H(2)O(2) plays a critical role in tumor promotion by arsenite through activation of the ERK1/2 and p70(s6k) signaling pathways.	arsenite	65-73	mitogen-activated protein kinase 3	Homo sapiens	203-209
14516795-9	2003	Taken together, these studies provide insight into mechanisms of arsenite-induced tumor promotion and suggest that H(2)O(2) plays a critical role in tumor promotion by arsenite through activation of the ERK1/2 and p70(s6k) signaling pathways.	arsenite	65-73	ubiquitin associated and SH3 domain containing B	Homo sapiens	214-217
14516795-9	2003	Taken together, these studies provide insight into mechanisms of arsenite-induced tumor promotion and suggest that H(2)O(2) plays a critical role in tumor promotion by arsenite through activation of the ERK1/2 and p70(s6k) signaling pathways.	arsenite	168-176	mitogen-activated protein kinase 3	Homo sapiens	203-209
14516795-9	2003	Taken together, these studies provide insight into mechanisms of arsenite-induced tumor promotion and suggest that H(2)O(2) plays a critical role in tumor promotion by arsenite through activation of the ERK1/2 and p70(s6k) signaling pathways.	arsenite	168-176	ubiquitin associated and SH3 domain containing B	Homo sapiens	214-217
14530437-4	2003	Transcript profiling of arsenite and antimony resistant mutants with these arrays pinpointed a number of genes overexpressed in mutants, including the ABC transporter PGPA, the glutathione biosynthesis genes gamma-glutamylcysteine synthetase (GSH1) and the glutathione synthetase (GSH2).	arsenite	24-32	glutamate-cysteine ligase catalytic subunit	Homo sapiens	208-241
14530437-4	2003	Transcript profiling of arsenite and antimony resistant mutants with these arrays pinpointed a number of genes overexpressed in mutants, including the ABC transporter PGPA, the glutathione biosynthesis genes gamma-glutamylcysteine synthetase (GSH1) and the glutathione synthetase (GSH2).	arsenite	24-32	GS homeobox 1	Homo sapiens	243-247
14530437-4	2003	Transcript profiling of arsenite and antimony resistant mutants with these arrays pinpointed a number of genes overexpressed in mutants, including the ABC transporter PGPA, the glutathione biosynthesis genes gamma-glutamylcysteine synthetase (GSH1) and the glutathione synthetase (GSH2).	arsenite	24-32	glutathione synthetase	Homo sapiens	257-279
14530437-4	2003	Transcript profiling of arsenite and antimony resistant mutants with these arrays pinpointed a number of genes overexpressed in mutants, including the ABC transporter PGPA, the glutathione biosynthesis genes gamma-glutamylcysteine synthetase (GSH1) and the glutathione synthetase (GSH2).	arsenite	24-32	GS homeobox 2	Homo sapiens	281-285
14511371-0	2003	Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both Glut4 translocation and p38 MAPK activity.	arsenite	0-8	solute carrier family 2 member 4	Homo sapiens	73-78
14511371-0	2003	Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both Glut4 translocation and p38 MAPK activity.	arsenite	0-8	mitogen-activated protein kinase 14	Homo sapiens	97-100
14511371-3	2003	By subcellular fractionation we observed that arsenite, like insulin, induces translocation of the GLUT1 and GLUT4 glucose transporters from the low-density membrane fraction to the plasma membrane.	arsenite	46-54	insulin	Homo sapiens	61-68
14511371-3	2003	By subcellular fractionation we observed that arsenite, like insulin, induces translocation of the GLUT1 and GLUT4 glucose transporters from the low-density membrane fraction to the plasma membrane.	arsenite	46-54	solute carrier family 2 member 1	Homo sapiens	99-104
14511371-3	2003	By subcellular fractionation we observed that arsenite, like insulin, induces translocation of the GLUT1 and GLUT4 glucose transporters from the low-density membrane fraction to the plasma membrane.	arsenite	46-54	solute carrier family 2 member 4	Homo sapiens	109-114
14511371-6	2003	However, arsenite-treatment did induce tyrosine-phosphorylation of c-Cbl.	arsenite	9-17	Cbl proto-oncogene	Homo sapiens	67-72
14511371-8	2003	Both arsenite and insulin-induced glucose uptake were inhibited partially by the p38 MAP kinase inhibitor, SB203580.	arsenite	5-13	mitogen-activated protein kinase 14	Homo sapiens	81-84
14511371-10	2003	Arsenite- and insulin-induced glucose uptake responded in a remarkably similar dose-dependent fashion to a range of pharmacological- and peptide-inhibitors for atypical PKC-lambda, a downstream target of PI-3" kinase signalling in insulin-induced glucose uptake.	arsenite	0-8	insulin	Homo sapiens	231-238
14511371-11	2003	These data show that in 3T3-L1 adipocytes both arsenite- and insulin-induced signalling pathways project towards a similar cellular response, namely GLUT1 and GLUT4 translocation and glucose uptake.	arsenite	47-55	solute carrier family 2 member 1	Homo sapiens	149-154
14511371-11	2003	These data show that in 3T3-L1 adipocytes both arsenite- and insulin-induced signalling pathways project towards a similar cellular response, namely GLUT1 and GLUT4 translocation and glucose uptake.	arsenite	47-55	solute carrier family 2 member 4	Homo sapiens	159-164
14511371-12	2003	This response to arsenite is not functionally linked to early steps of the IR-IRS-PI-3" kinase pathway, but does coincide with c-Cbl phosphorylation, basal levels of PKC-lambda activity and p38 MAPK activation.	arsenite	17-25	Cbl proto-oncogene	Homo sapiens	127-132
14511371-12	2003	This response to arsenite is not functionally linked to early steps of the IR-IRS-PI-3" kinase pathway, but does coincide with c-Cbl phosphorylation, basal levels of PKC-lambda activity and p38 MAPK activation.	arsenite	17-25	mitogen-activated protein kinase 14	Homo sapiens	190-193
14583462-11	2003	In addition, the association of Mad2 with the APC/C(cdc20) complex and the accumulation of Pds1, an anaphase inhibitor, were remarkably reduced in arsenite-arrested mitotic cells as compared with nocodazole-arrested mitotic cells.	arsenite	147-155	mitotic arrest deficient 2 like 1	Homo sapiens	32-36
14583462-11	2003	In addition, the association of Mad2 with the APC/C(cdc20) complex and the accumulation of Pds1, an anaphase inhibitor, were remarkably reduced in arsenite-arrested mitotic cells as compared with nocodazole-arrested mitotic cells.	arsenite	147-155	cell division cycle 20	Homo sapiens	52-57
14583462-11	2003	In addition, the association of Mad2 with the APC/C(cdc20) complex and the accumulation of Pds1, an anaphase inhibitor, were remarkably reduced in arsenite-arrested mitotic cells as compared with nocodazole-arrested mitotic cells.	arsenite	147-155	Pigment dispersion syndrome-1	Homo sapiens	91-95
12958179-7	2003	Treatment of stable L1-3 transfectants with 50 microM arsenite induced more significant formation of intracellular hydroperoxides than that of vector-control cells.	arsenite	54-62	immunoglobulin kappa variable 2-4 (pseudogene)	Homo sapiens	20-24
12946653-0	2003	The protective role of NF-kappaB and AP-1 in arsenite-induced apoptosis in aortic endothelial cells.	arsenite	45-53	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	37-41
12946653-4	2003	Here we demonstrated that arsenite exposure induced apoptosis accompanied by the occurrence of apoptotic signals including degradation of poly(ADP-ribose) polymerase (PARP) and CPP32 (cleavage/activation) and DNA ladder formation.	arsenite	26-34	poly(ADP-ribose) polymerase 1	Homo sapiens	138-165
12946653-4	2003	Here we demonstrated that arsenite exposure induced apoptosis accompanied by the occurrence of apoptotic signals including degradation of poly(ADP-ribose) polymerase (PARP) and CPP32 (cleavage/activation) and DNA ladder formation.	arsenite	26-34	poly(ADP-ribose) polymerase 1	Homo sapiens	167-171
12946653-4	2003	Here we demonstrated that arsenite exposure induced apoptosis accompanied by the occurrence of apoptotic signals including degradation of poly(ADP-ribose) polymerase (PARP) and CPP32 (cleavage/activation) and DNA ladder formation.	arsenite	26-34	caspase 3	Homo sapiens	177-182
12946653-5	2003	By using the luciferase reporter assay, we demonstrated that arsenite exposure differentially activated two redox-sensitive transcription factors, NF-kappaB and AP-1.	arsenite	61-69	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	161-165
12946653-6	2003	Lower levels of arsenite exposure (25 microM NaAsO(2), 24 h) induced co-activation of NF-kappaB and AP-1, accompanied by 9% total apoptosis.	arsenite	16-24	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	100-104
12946653-7	2003	In contrast, higher levels of arsenite exposure (40 microM NaAsO(2), 24 h) induced higher levels of AP-1 activation, accompanied by 45% total apoptosis.	arsenite	30-38	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	100-104
12946653-8	2003	Blockade of NF-kappaB or JNK activity further enhanced arsenite-induced apoptosis.	arsenite	55-63	mitogen-activated protein kinase 8	Homo sapiens	25-28
12946653-10	2003	Based on these data, we propose that activation of redox-sensitive transcription factors, NF-kappaB and AP-1, plays a very important role in the protection of PAECs from arsenite-induced apoptosis.	arsenite	170-178	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	104-108
14516795-2	2003	Arsenite treatment resulted in the persistent activation of p70(s6k) and extracellular signal-regulated kinase 1/2 (ERK1/2) which was accompanied by an increase in intracellular ROS production.	arsenite	0-8	ribosomal protein S6 kinase B1	Homo sapiens	60-67
14516795-2	2003	Arsenite treatment resulted in the persistent activation of p70(s6k) and extracellular signal-regulated kinase 1/2 (ERK1/2) which was accompanied by an increase in intracellular ROS production.	arsenite	0-8	mitogen-activated protein kinase 1	Homo sapiens	73-114
14516795-2	2003	Arsenite treatment resulted in the persistent activation of p70(s6k) and extracellular signal-regulated kinase 1/2 (ERK1/2) which was accompanied by an increase in intracellular ROS production.	arsenite	0-8	mitogen-activated protein kinase 3	Homo sapiens	116-122
14516795-4	2003	Elimination of H(2)O(2) by catalase or N-acetyl-L-cysteine inhibited the arsenite-induced activation of p70(s6k) and ERK1/2, indicating the possible role of H(2)O(2) in the arsenite activation of the p70(s6k) and the ERK1/2 signaling pathways.	arsenite	73-81	ribosomal protein S6 kinase B1	Homo sapiens	104-111
14516795-4	2003	Elimination of H(2)O(2) by catalase or N-acetyl-L-cysteine inhibited the arsenite-induced activation of p70(s6k) and ERK1/2, indicating the possible role of H(2)O(2) in the arsenite activation of the p70(s6k) and the ERK1/2 signaling pathways.	arsenite	73-81	mitogen-activated protein kinase 3	Homo sapiens	117-123
14516795-4	2003	Elimination of H(2)O(2) by catalase or N-acetyl-L-cysteine inhibited the arsenite-induced activation of p70(s6k) and ERK1/2, indicating the possible role of H(2)O(2) in the arsenite activation of the p70(s6k) and the ERK1/2 signaling pathways.	arsenite	73-81	ribosomal protein S6 kinase B1	Homo sapiens	200-207
14516795-4	2003	Elimination of H(2)O(2) by catalase or N-acetyl-L-cysteine inhibited the arsenite-induced activation of p70(s6k) and ERK1/2, indicating the possible role of H(2)O(2) in the arsenite activation of the p70(s6k) and the ERK1/2 signaling pathways.	arsenite	73-81	mitogen-activated protein kinase 3	Homo sapiens	217-223
14516795-4	2003	Elimination of H(2)O(2) by catalase or N-acetyl-L-cysteine inhibited the arsenite-induced activation of p70(s6k) and ERK1/2, indicating the possible role of H(2)O(2) in the arsenite activation of the p70(s6k) and the ERK1/2 signaling pathways.	arsenite	173-181	ribosomal protein S6 kinase B1	Homo sapiens	104-111
14516795-5	2003	A specific inhibitor of p70(s6k), rapamycin, and calcium chelators significantly blocked the activation of p70(s6k) induced by arsenite.	arsenite	127-135	ubiquitin associated and SH3 domain containing B	Homo sapiens	24-27
14516795-5	2003	A specific inhibitor of p70(s6k), rapamycin, and calcium chelators significantly blocked the activation of p70(s6k) induced by arsenite.	arsenite	127-135	ubiquitin associated and SH3 domain containing B	Homo sapiens	107-110
14516795-6	2003	While the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002 completely abrogated arsenite activation of p70(s6k), ERK1/2 activation by arsenite was not affected by these inhibitors, indicating that H(2)O(2) might act as an upstream molecule of PI3K as well as ERK1/2.	arsenite	103-111	ribosomal protein S6 kinase B1	Homo sapiens	126-133
14516795-6	2003	While the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002 completely abrogated arsenite activation of p70(s6k), ERK1/2 activation by arsenite was not affected by these inhibitors, indicating that H(2)O(2) might act as an upstream molecule of PI3K as well as ERK1/2.	arsenite	103-111	mitogen-activated protein kinase 3	Homo sapiens	136-142
14516795-6	2003	While the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002 completely abrogated arsenite activation of p70(s6k), ERK1/2 activation by arsenite was not affected by these inhibitors, indicating that H(2)O(2) might act as an upstream molecule of PI3K as well as ERK1/2.	arsenite	103-111	mitogen-activated protein kinase 3	Homo sapiens	282-288
14516795-6	2003	While the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002 completely abrogated arsenite activation of p70(s6k), ERK1/2 activation by arsenite was not affected by these inhibitors, indicating that H(2)O(2) might act as an upstream molecule of PI3K as well as ERK1/2.	arsenite	157-165	mitogen-activated protein kinase 3	Homo sapiens	136-142
12928150-4	2003	We screened two genes responsible for arsenic metabolism, human purine nucleoside phosphorylase (hNP), which functions as an arsenate reductase converting arsenate to arsenite, and human glutathione S-transferase omega 1-1 (hGSTO1-1), which functions as a monomethylarsonic acid (MMA) reductase, converting MMA(V) to MMA(III), to develop a comprehensive catalog of commonly occurring genetic polymorphisms in these genes.	arsenite	167-175	purine nucleoside phosphorylase	Homo sapiens	64-95
12781867-4	2003	These data show that while the arsenite-induced increase in the phosphorylation of eIF4E and hsp25 was sensitive to SB203580 in cells expressing WT-SAPK2a, these responses to SB203580 were abrogated in cells expressing DR-SAPK2a.	arsenite	31-39	eukaryotic translation initiation factor 4E	Homo sapiens	83-88
12781867-4	2003	These data show that while the arsenite-induced increase in the phosphorylation of eIF4E and hsp25 was sensitive to SB203580 in cells expressing WT-SAPK2a, these responses to SB203580 were abrogated in cells expressing DR-SAPK2a.	arsenite	31-39	heat shock protein family B (small) member 1	Homo sapiens	93-98
12781867-4	2003	These data show that while the arsenite-induced increase in the phosphorylation of eIF4E and hsp25 was sensitive to SB203580 in cells expressing WT-SAPK2a, these responses to SB203580 were abrogated in cells expressing DR-SAPK2a.	arsenite	31-39	mitogen-activated protein kinase 14	Homo sapiens	148-154
12928150-4	2003	We screened two genes responsible for arsenic metabolism, human purine nucleoside phosphorylase (hNP), which functions as an arsenate reductase converting arsenate to arsenite, and human glutathione S-transferase omega 1-1 (hGSTO1-1), which functions as a monomethylarsonic acid (MMA) reductase, converting MMA(V) to MMA(III), to develop a comprehensive catalog of commonly occurring genetic polymorphisms in these genes.	arsenite	167-175	kallikrein related peptidase 8	Homo sapiens	97-100
12877744-2	2003	The arsC gene, which codes for an arsenate reductase is essential for arsenate resistance and transforms arsenate into arsenite, which is extruded from the cell.	arsenite	119-127	steroid sulfatase	Homo sapiens	4-8
12839928-3	2003	Our results show that activation of p38 by adenoviral expression of MKK3b or arsenite treatment was followed by rapid dephosphorylation of MEK1,2 and subsequent apoptosis in human skin fibroblasts.	arsenite	77-85	mitogen-activated protein kinase 14	Homo sapiens	36-39
12682056-1	2003	Arsenate reductase (ArsC) from Staphylococcus aureus plasmid pI258 catalyzes the reduction of arsenate to arsenite and plays a role in bacterial heavy metal resistance.	arsenite	106-114	Arsenate reductase	Staphylococcus aureus	0-18
12682056-1	2003	Arsenate reductase (ArsC) from Staphylococcus aureus plasmid pI258 catalyzes the reduction of arsenate to arsenite and plays a role in bacterial heavy metal resistance.	arsenite	106-114	Arsenate reductase	Staphylococcus aureus	20-24
12839928-3	2003	Our results show that activation of p38 by adenoviral expression of MKK3b or arsenite treatment was followed by rapid dephosphorylation of MEK1,2 and subsequent apoptosis in human skin fibroblasts.	arsenite	77-85	mitogen-activated protein kinase kinase 1	Homo sapiens	139-145
12730627-0	2003	Reversal of Bcl-2-mediated resistance of the EW36 human B-cell lymphoma cell line to arsenite- and pesticide-induced apoptosis by PK11195, a ligand of the mitochondrial benzodiazepine receptor.	arsenite	85-93	BCL2 apoptosis regulator	Homo sapiens	12-17
12730627-0	2003	Reversal of Bcl-2-mediated resistance of the EW36 human B-cell lymphoma cell line to arsenite- and pesticide-induced apoptosis by PK11195, a ligand of the mitochondrial benzodiazepine receptor.	arsenite	85-93	translocator protein	Homo sapiens	155-192
14758801-1	2003	The article highlighted in this issue is "Reversal of Bcl-2 Mediated Resistance of the EW36 Human B-Cell Lymphoma Cell Line to Arsenite and Pesticide-Induced Apoptosis by PK11195, a Ligand of the Mitochondrial Benzodiazepine Receptor" by Donna E. Muscarella, Kerry A. O"Brien, Ann T. Lemley, and Stephen E Bloom from Cornell University in Ithaca, NY (pp.	arsenite	127-135	BCL2 apoptosis regulator	Homo sapiens	54-59
14758801-1	2003	The article highlighted in this issue is "Reversal of Bcl-2 Mediated Resistance of the EW36 Human B-Cell Lymphoma Cell Line to Arsenite and Pesticide-Induced Apoptosis by PK11195, a Ligand of the Mitochondrial Benzodiazepine Receptor" by Donna E. Muscarella, Kerry A. O"Brien, Ann T. Lemley, and Stephen E Bloom from Cornell University in Ithaca, NY (pp.	arsenite	127-135	translocator protein	Homo sapiens	196-233
12767237-7	2003	In addition, autophosphorylation of Thr485 was necessary for arsenite-induced activation of the eIF2alpha kinase activity of HRI, while autophosphorylation at Thr483 was not required for activation by arsenite.	arsenite	61-69	eukaryotic translation initiation factor 2A	Homo sapiens	96-105
12767237-7	2003	In addition, autophosphorylation of Thr485 was necessary for arsenite-induced activation of the eIF2alpha kinase activity of HRI, while autophosphorylation at Thr483 was not required for activation by arsenite.	arsenite	61-69	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	125-128
12711313-3	2003	The S. pombe and wheat phytochelatin synthase (PCS) genes, when expressed in S. cerevisiae, mediate only modest resistance to arsenite and thus cannot functionally compensate for Acr3p.	arsenite	126-134	glutathione gamma-glutamylcysteinyltransferase 1	Triticum aestivum	47-50
12796304-1	2003	Ycf1p, a member of the yeast multidrug resistance-associated protein (MRP) subfamily of ATP-binding cassette proteins, is a vacuolar membrane transporter that confers resistance to a variety of toxic substances such as cadmium and arsenite.	arsenite	231-239	ATP-binding cassette glutathione S-conjugate transporter YCF1	Saccharomyces cerevisiae S288C	0-5
12796304-6	2003	Instead, the L6(ins) appears to regulate substrate specificity of Ycf1p, since certain mutations in this region lower cellular cadmium resistance with a concomitant gain in arsenite resistance.	arsenite	173-181	ATP-binding cassette glutathione S-conjugate transporter YCF1	Saccharomyces cerevisiae S288C	66-71
12745069-3	2003	Treatment of cultured MC3T3-E1 osteoblasts with arsenite or arsenate induced increase of Nrf2, followed by transcriptional activation of target genes encoding HO-1, Prx I, and A170.	arsenite	48-56	NFE2 like bZIP transcription factor 2	Homo sapiens	89-93
12745069-3	2003	Treatment of cultured MC3T3-E1 osteoblasts with arsenite or arsenate induced increase of Nrf2, followed by transcriptional activation of target genes encoding HO-1, Prx I, and A170.	arsenite	48-56	peroxiredoxin 1	Homo sapiens	165-170
12745069-3	2003	Treatment of cultured MC3T3-E1 osteoblasts with arsenite or arsenate induced increase of Nrf2, followed by transcriptional activation of target genes encoding HO-1, Prx I, and A170.	arsenite	48-56	sequestosome 1	Homo sapiens	176-180
12745069-6	2003	Arsenite (50-100 micro M) also induced accumulation of HMM-A170 and ubiquitin-conjugated proteins.	arsenite	0-8	sequestosome 1	Homo sapiens	55-63
12637567-2	2003	Since mitogen-activated protein kinases (MAPKs) are involved in stress signaling we investigated the role of arsenite and MAPKs for HO-1 gene regulation in primary rat hepatocytes.	arsenite	109-117	heme oxygenase 1	Rattus norvegicus	132-136
12711313-3	2003	The S. pombe and wheat phytochelatin synthase (PCS) genes, when expressed in S. cerevisiae, mediate only modest resistance to arsenite and thus cannot functionally compensate for Acr3p.	arsenite	126-134	glutathione gamma-glutamylcysteinyltransferase 1	Triticum aestivum	23-45
12614848-0	2003	Caspase activation is accelerated by the inhibition of arsenite-induced, membrane rafts-dependent Akt activation.	arsenite	55-63	AKT serine/threonine kinase 1	Homo sapiens	98-101
12547826-0	2003	Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts.	arsenite	15-23	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	84-89
12547826-0	2003	Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts.	arsenite	15-23	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	94-99
12547826-3	2003	We have shown previously that arsenite can potently activate the mitogen-activated protein kinase cascades and induce the expression of proliferation-associated genes, including proto-oncogenes c-jun and c-fos.	arsenite	30-38	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	194-199
12547826-3	2003	We have shown previously that arsenite can potently activate the mitogen-activated protein kinase cascades and induce the expression of proliferation-associated genes, including proto-oncogenes c-jun and c-fos.	arsenite	30-38	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	204-209
12547826-4	2003	In order to elucidate further the molecular mechanisms underlying its tumor-promoting properties, we investigated the signaling events involved in arsenite-mediated induction of c-fos and c-jun.	arsenite	147-155	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	178-183
12547826-4	2003	In order to elucidate further the molecular mechanisms underlying its tumor-promoting properties, we investigated the signaling events involved in arsenite-mediated induction of c-fos and c-jun.	arsenite	147-155	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	188-193
12547826-5	2003	We found that induction of both c-fos and c-jun by arsenite can be substantially inhibited by the MEK- selective inhibitor U0126, suggesting that the ERK pathway is critically involved in their up-regulation.	arsenite	51-59	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	32-37
12547826-5	2003	We found that induction of both c-fos and c-jun by arsenite can be substantially inhibited by the MEK- selective inhibitor U0126, suggesting that the ERK pathway is critically involved in their up-regulation.	arsenite	51-59	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	42-47
12547826-5	2003	We found that induction of both c-fos and c-jun by arsenite can be substantially inhibited by the MEK- selective inhibitor U0126, suggesting that the ERK pathway is critically involved in their up-regulation.	arsenite	51-59	mitogen-activated protein kinase kinase 7	Homo sapiens	98-101
12547826-5	2003	We found that induction of both c-fos and c-jun by arsenite can be substantially inhibited by the MEK- selective inhibitor U0126, suggesting that the ERK pathway is critically involved in their up-regulation.	arsenite	51-59	mitogen-activated protein kinase 1	Homo sapiens	150-153
12547826-6	2003	Interestingly, arsenite dramatically induced the phosphorylation and acetylation of histone H3 preceding the induction of mRNAs encoding c-fos and c-jun.	arsenite	15-23	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	137-142
12547826-6	2003	Interestingly, arsenite dramatically induced the phosphorylation and acetylation of histone H3 preceding the induction of mRNAs encoding c-fos and c-jun.	arsenite	15-23	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	147-152
12547826-7	2003	Finally, chromatin immunoprecipitation assays revealed that arsenite treatment markedly induced the phosphorylation/acetylation of histone H3 associated with the c-fos and c-jun genes through an ERK-dependent pathway.	arsenite	60-68	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	162-167
12547826-7	2003	Finally, chromatin immunoprecipitation assays revealed that arsenite treatment markedly induced the phosphorylation/acetylation of histone H3 associated with the c-fos and c-jun genes through an ERK-dependent pathway.	arsenite	60-68	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	172-177
12547826-7	2003	Finally, chromatin immunoprecipitation assays revealed that arsenite treatment markedly induced the phosphorylation/acetylation of histone H3 associated with the c-fos and c-jun genes through an ERK-dependent pathway.	arsenite	60-68	mitogen-activated protein kinase 1	Homo sapiens	195-198
12854658-10	2003	CONCLUSIONS: If arsenite produces exencephaly by inactivating the Pax3 protein, then the fact that the exencephaly rate was increased in Sp/Sp embryos with no functional Pax3 indicates that arsenite may either induce this defect through additional pathways, or may alter the response via modifier genes.	arsenite	16-24	paired box 3	Mus musculus	66-70
12854658-10	2003	CONCLUSIONS: If arsenite produces exencephaly by inactivating the Pax3 protein, then the fact that the exencephaly rate was increased in Sp/Sp embryos with no functional Pax3 indicates that arsenite may either induce this defect through additional pathways, or may alter the response via modifier genes.	arsenite	190-198	paired box 3	Mus musculus	66-70
12676608-5	2003	In cultured human aortic endothelial cells, treatment with arsenite resulted in a concentration-dependent inhibition of endothelial nitric oxide synthase (eNOS).	arsenite	59-67	nitric oxide synthase 3	Homo sapiens	120-153
12640124-0	2003	Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity.	arsenite	87-95	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	35-64
12640124-0	2003	Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity.	arsenite	87-95	AKT serine/threonine kinase 1	Homo sapiens	65-68
12640124-6	2003	In contrast to its extensively documented antiapoptotic influence, the elevated activity of Akt appears to be important in sensitizing caveolin-expressing cells to arsenite-induced toxicity, as both pretreatment of cells with the PI3K inhibitor wortmannin and overexpression of a dominant-negative Akt mutant markedly improved the survival of arsenite-treated cells.	arsenite	164-172	AKT serine/threonine kinase 1	Homo sapiens	92-95
12640124-6	2003	In contrast to its extensively documented antiapoptotic influence, the elevated activity of Akt appears to be important in sensitizing caveolin-expressing cells to arsenite-induced toxicity, as both pretreatment of cells with the PI3K inhibitor wortmannin and overexpression of a dominant-negative Akt mutant markedly improved the survival of arsenite-treated cells.	arsenite	164-172	caveolin 1	Homo sapiens	135-143
12640124-6	2003	In contrast to its extensively documented antiapoptotic influence, the elevated activity of Akt appears to be important in sensitizing caveolin-expressing cells to arsenite-induced toxicity, as both pretreatment of cells with the PI3K inhibitor wortmannin and overexpression of a dominant-negative Akt mutant markedly improved the survival of arsenite-treated cells.	arsenite	343-351	AKT serine/threonine kinase 1	Homo sapiens	92-95
12640124-8	2003	In summary, our results indicate that caveolin-induced upregulation of the PI3K/Akt signaling pathway, which appears to be a death signal in the presence of arsenite and H(2)O(2), sensitizes cells to environmental stress.	arsenite	157-165	caveolin 1	Homo sapiens	38-46
12640124-8	2003	In summary, our results indicate that caveolin-induced upregulation of the PI3K/Akt signaling pathway, which appears to be a death signal in the presence of arsenite and H(2)O(2), sensitizes cells to environmental stress.	arsenite	157-165	AKT serine/threonine kinase 1	Homo sapiens	80-83
12650666-2	2003	A previous report has demonstrated that arsenite-induced phosphorylation of Mre11, a protein involved in the repair of DNA double strand breaks (DSBs), is M phase-dependent and requires the Nijmegen breakage syndrome (NBS) protein, NBS1 [DNA Repair 1 (2002) 137].	arsenite	40-48	MRE11 homolog, double strand break repair nuclease	Homo sapiens	76-81
12650666-2	2003	A previous report has demonstrated that arsenite-induced phosphorylation of Mre11, a protein involved in the repair of DNA double strand breaks (DSBs), is M phase-dependent and requires the Nijmegen breakage syndrome (NBS) protein, NBS1 [DNA Repair 1 (2002) 137].	arsenite	40-48	nibrin	Homo sapiens	232-236
12650666-5	2003	Arsenite-induced NO generation is impaired in DSB repair-defective NBS cells, but not in NBS1-reconstituted NBS cells, suggesting NBS1 is required for effective NO generation.	arsenite	0-8	nibrin	Homo sapiens	130-134
12650666-6	2003	In summary, our study showed, for the first time, that arsenite-induced NO generation is cell-cycle- and NBS1-dependent.	arsenite	55-63	nibrin	Homo sapiens	105-109
12660817-2	2003	Previously, expression cloning for cDNAs whose overexpression confers arsenite-resistance in Chinese hamster V79 cells identified two genes: fau and a novel gene, asr2.	arsenite	70-78	40S ribosomal protein S30	Cricetulus griseus	141-144
12660817-2	2003	Previously, expression cloning for cDNAs whose overexpression confers arsenite-resistance in Chinese hamster V79 cells identified two genes: fau and a novel gene, asr2.	arsenite	70-78	serrate RNA effector molecule homolog	Cricetulus griseus	163-167
12660819-0	2003	Immediate-early gene induction by the stresses anisomycin and arsenite in human osteosarcoma cells involves MAPK cascade signaling to Elk-1, CREB and SRF.	arsenite	62-70	ETS transcription factor ELK1	Homo sapiens	134-139
12660819-0	2003	Immediate-early gene induction by the stresses anisomycin and arsenite in human osteosarcoma cells involves MAPK cascade signaling to Elk-1, CREB and SRF.	arsenite	62-70	cAMP responsive element binding protein 1	Homo sapiens	141-145
12660819-0	2003	Immediate-early gene induction by the stresses anisomycin and arsenite in human osteosarcoma cells involves MAPK cascade signaling to Elk-1, CREB and SRF.	arsenite	62-70	serum response factor	Homo sapiens	150-153
12660819-8	2003	Thus, all three MAPK cascades mediate anisomycin- and arsenite-induced signaling to IEG promoters in HOS cells through the differential targeting of Elk-1, SRF and CREB.	arsenite	54-62	ETS transcription factor ELK1	Homo sapiens	149-154
12660819-8	2003	Thus, all three MAPK cascades mediate anisomycin- and arsenite-induced signaling to IEG promoters in HOS cells through the differential targeting of Elk-1, SRF and CREB.	arsenite	54-62	serum response factor	Homo sapiens	156-159
12660819-8	2003	Thus, all three MAPK cascades mediate anisomycin- and arsenite-induced signaling to IEG promoters in HOS cells through the differential targeting of Elk-1, SRF and CREB.	arsenite	54-62	cAMP responsive element binding protein 1	Homo sapiens	164-168
12642610-3	2003	Here, we show that G3BP, a phosphorylation-dependent endoribonuclease that interacts with RasGAP, is recruited to SGs in cells exposed to arsenite.	arsenite	138-146	G3BP stress granule assembly factor 1	Homo sapiens	19-23
12642610-3	2003	Here, we show that G3BP, a phosphorylation-dependent endoribonuclease that interacts with RasGAP, is recruited to SGs in cells exposed to arsenite.	arsenite	138-146	RAS p21 protein activator 1	Homo sapiens	90-96
12642610-6	2003	This region binds RasGAP and contains serine 149, whose dephosphorylation is induced by arsenite treatment.	arsenite	88-96	RAS p21 protein activator 1	Homo sapiens	18-24
12641425-3	2003	Here, we compare the effects of sodium selenite and mono-, di-, and trimethylated selenium compounds on the methylation of arsenite by purified recombinant rat As(III)-methyltransferase (Cyt19) and by primary rat and human hepatocytes.	arsenite	123-131	arsenite methyltransferase	Rattus norvegicus	187-192
12641442-1	2003	Arsenite was shown to inhibit pyruvate dehydrogenase (PDH) activity through binding to vicinal dithiols in pure enzyme and tissue extract.	arsenite	0-8	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	54-57
12641442-2	2003	However, no data are available on how arsenite inhibits PDH activity in human cells.	arsenite	38-46	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	56-59
12614848-7	2003	These results suggested that selective blockade of the arsenite-provoked PI-3 kinase/Akt pathway can promote the arsenite-triggered pathway for caspase activation, and this may open a new study area for wider applications of arsenic as a drug for treating various kinds of leukemia.	arsenite	55-63	AKT serine/threonine kinase 1	Homo sapiens	85-88
12614848-7	2003	These results suggested that selective blockade of the arsenite-provoked PI-3 kinase/Akt pathway can promote the arsenite-triggered pathway for caspase activation, and this may open a new study area for wider applications of arsenic as a drug for treating various kinds of leukemia.	arsenite	113-121	AKT serine/threonine kinase 1	Homo sapiens	85-88
12650620-8	2003	Rice hsp101 cDNA expression in hsp104 deficient yeast also caused recovery in tolerance against arsenite.	arsenite	96-104	heat shock protein 101	Arabidopsis thaliana	5-11
12529330-0	2003	Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1.	arsenite	0-8	thymoma viral proto-oncogene 1	Mus musculus	75-79
12529330-0	2003	Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1.	arsenite	0-8	mitogen-activated protein kinase 1	Mus musculus	81-120
12529330-4	2003	Arsenite induces phosphorylation of Akt1 at serine 473 and increases Akt1 activity.	arsenite	0-8	thymoma viral proto-oncogene 1	Mus musculus	36-40
12529330-4	2003	Arsenite induces phosphorylation of Akt1 at serine 473 and increases Akt1 activity.	arsenite	0-8	thymoma viral proto-oncogene 1	Mus musculus	69-73
12529330-5	2003	A dominant-negative mutant of Akt1 inhibits the arsenite-induced phosphorylation of histone H3 at serine 10.	arsenite	48-56	thymoma viral proto-oncogene 1	Mus musculus	30-34
12529330-7	2003	The arsenite-induced phosphorylation of histone H3 at serine 10 was almost completely blocked by a dominant-negative mutant of extracellular signal-regulated kinase 2 and the mitogen-activated protein kinase/extracellular signal-regulated kinase inhibitor PD98059.	arsenite	4-12	mitogen-activated protein kinase 1	Mus musculus	127-166
12529330-10	2003	Taken together, these results suggested that arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2 and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1.	arsenite	45-53	thymoma viral proto-oncogene 1	Mus musculus	120-124
12529330-10	2003	Taken together, these results suggested that arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2 and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1.	arsenite	45-53	mitogen-activated protein kinase 1	Mus musculus	126-165
12475989-4	2003	We report opposite effects of the p38 isoforms on regulation of AP-1-dependent activities by p38 activators MAPK kinase 6 (MKK6) and/or arsenite in human breast cancer cells.	arsenite	136-144	mitogen-activated protein kinase 14	Homo sapiens	34-37
12475989-5	2003	The p38beta isoform increases the activation of AP-1 transcriptional activities by MKK6 and/or arsenite, whereas p38gamma/p38delta inhibits or has no effect on the stimulation.	arsenite	95-103	mitogen-activated protein kinase 11	Mus musculus	4-11
12464623-0	2003	Cross-linking of surface IgM in the Burkitt"s lymphoma cell line ST486 provides protection against arsenite- and stress-induced apoptosis that is mediated by ERK and phosphoinositide 3-kinase signaling pathways.	arsenite	99-107	mitogen-activated protein kinase 1	Homo sapiens	158-161
12464623-5	2003	We examined the question of whether IgM-mediated activation of the ERK and PI3K pathways can influence the apoptotic response of ST486 cells following exposure to arsenite and selected drugs with different molecular targets, including cycloheximide, etoposide, and camptothecin, and a physical stress, hyperthermia.	arsenite	163-171	mitogen-activated protein kinase 1	Homo sapiens	67-70
12614848-4	2003	Arsenite-induced Akt phosphorylation also was inhibited by sequestrating membrane cholesterol with beta cyclodextrin.	arsenite	0-8	AKT serine/threonine kinase 1	Homo sapiens	17-20
12614848-5	2003	Reducing reagents/reactive oxygen species (ROS) scavengers reduced arsenite-induced Akt phosphorylation and beta cyclodextrin reduced arsenite-mediated ROS production, suggesting that arsenite-induced G-protein/Akt/GSK3beta pathway is membrane raft dependent and redox linked.	arsenite	67-75	AKT serine/threonine kinase 1	Homo sapiens	84-87
12614848-5	2003	Reducing reagents/reactive oxygen species (ROS) scavengers reduced arsenite-induced Akt phosphorylation and beta cyclodextrin reduced arsenite-mediated ROS production, suggesting that arsenite-induced G-protein/Akt/GSK3beta pathway is membrane raft dependent and redox linked.	arsenite	67-75	AKT serine/threonine kinase 1	Homo sapiens	211-214
12614848-5	2003	Reducing reagents/reactive oxygen species (ROS) scavengers reduced arsenite-induced Akt phosphorylation and beta cyclodextrin reduced arsenite-mediated ROS production, suggesting that arsenite-induced G-protein/Akt/GSK3beta pathway is membrane raft dependent and redox linked.	arsenite	67-75	glycogen synthase kinase 3 beta	Homo sapiens	215-223
14576462-8	2003	Reduction of arachidonate metabolism through 12(S)-lipoxygenase and cyclooxygenase 1 and that of the arsenite-induced generation of reactive oxygen species are observed in cells overexpressing PHGPx.	arsenite	101-109	glutathione peroxidase 4	Homo sapiens	193-198
12802802-8	2003	We also found that arsenite induced gene amplification of the dihydrofolate reductase (DHFR) gene in a dose-dependent manner.	arsenite	19-27	dihydrofolate reductase	Homo sapiens	62-85
12802802-8	2003	We also found that arsenite induced gene amplification of the dihydrofolate reductase (DHFR) gene in a dose-dependent manner.	arsenite	19-27	dihydrofolate reductase	Homo sapiens	87-91
12475910-4	2003	In this study, we show that short-time exposures to 0.1-5 microM arsenite (iAsIII) or the methylated trivalent arsenicals methylarsine oxide (MAsIIIO), or iododimethylarsine (DMAsIIII) induce phosphorylation of c-Jun and increase AP-1 DNA binding activity in human bladder epithelial cells.	arsenite	65-73	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	211-216
12475910-4	2003	In this study, we show that short-time exposures to 0.1-5 microM arsenite (iAsIII) or the methylated trivalent arsenicals methylarsine oxide (MAsIIIO), or iododimethylarsine (DMAsIIII) induce phosphorylation of c-Jun and increase AP-1 DNA binding activity in human bladder epithelial cells.	arsenite	65-73	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	230-234
14576462-9	2003	On the other hand, enhancement of arachidonate metabolism and the arsenite-induced generation of reactive oxygen species is detected in PHGPx-depleted cells.	arsenite	66-74	glutathione peroxidase 4	Homo sapiens	136-141
12608580-0	2003	Overexpression and increased DNA topoisomerase II-like enzyme activity in arsenite resistant Leishmania donovani.	arsenite	74-82	DNA topoisomerase ii	Leishmania donovani	29-49
12488483-4	2002	After 29 weeks of exposure, the arsenite-exposed RWPE-1 cells (referred to as CAsE-PE) showed a marked increase in matrix metalloproteinase-9 secretion, a common finding in prostate malignancies.	arsenite	32-40	matrix metallopeptidase 9	Homo sapiens	115-141
12359242-7	2002	Furthermore, we also found that arsenite decreased the activity of the 8-OH-Gua repair enzyme, hOGG1 (8-oxoguanine-DNA glycosylase 1) as well as its gene and protein expression.	arsenite	32-40	8-oxoguanine DNA glycosylase	Homo sapiens	95-100
12460802-10	2002	The substantial level of basal expression of hsp 27, hsp 60, and hsc 70 shown previously in human bladder urothelium, coupled with the inducible expression of hsp 70, could provide the human urothelium with a mechanism to withstand and recover from a low level of arsenite exposure.	arsenite	264-272	heat shock protein family B (small) member 1	Homo sapiens	45-51
12460802-10	2002	The substantial level of basal expression of hsp 27, hsp 60, and hsc 70 shown previously in human bladder urothelium, coupled with the inducible expression of hsp 70, could provide the human urothelium with a mechanism to withstand and recover from a low level of arsenite exposure.	arsenite	264-272	heat shock protein family A (Hsp70) member 8	Homo sapiens	65-71
12460802-10	2002	The substantial level of basal expression of hsp 27, hsp 60, and hsc 70 shown previously in human bladder urothelium, coupled with the inducible expression of hsp 70, could provide the human urothelium with a mechanism to withstand and recover from a low level of arsenite exposure.	arsenite	264-272	heat shock protein family A (Hsp70) member 4	Homo sapiens	159-165
12472888-10	2002	The results show that transient arsenite pre-treatment induces Hsp72, HO-1 and, to a lesser extent, Hsp27; it reduces H2O2-induced astrocyte death; and it causes selective activation of Akt following H2O2.	arsenite	32-40	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	63-68
12472888-10	2002	The results show that transient arsenite pre-treatment induces Hsp72, HO-1 and, to a lesser extent, Hsp27; it reduces H2O2-induced astrocyte death; and it causes selective activation of Akt following H2O2.	arsenite	32-40	heme oxygenase 1	Rattus norvegicus	70-74
12472888-10	2002	The results show that transient arsenite pre-treatment induces Hsp72, HO-1 and, to a lesser extent, Hsp27; it reduces H2O2-induced astrocyte death; and it causes selective activation of Akt following H2O2.	arsenite	32-40	heat shock protein family B (small) member 1	Rattus norvegicus	100-105
12472888-10	2002	The results show that transient arsenite pre-treatment induces Hsp72, HO-1 and, to a lesser extent, Hsp27; it reduces H2O2-induced astrocyte death; and it causes selective activation of Akt following H2O2.	arsenite	32-40	AKT serine/threonine kinase 1	Rattus norvegicus	186-189
12368812-2	2002	The Escherichia coli arsC gene encodes arsenate reductase (ArsC), which catalyzes the glutathione (GSH)-coupled electrochemical reduction of arsenate to the more toxic arsenite.	arsenite	168-176	Arsenate reductase	Escherichia coli	21-25
12368812-2	2002	The Escherichia coli arsC gene encodes arsenate reductase (ArsC), which catalyzes the glutathione (GSH)-coupled electrochemical reduction of arsenate to the more toxic arsenite.	arsenite	168-176	Arsenate reductase	Escherichia coli	39-57
12368812-2	2002	The Escherichia coli arsC gene encodes arsenate reductase (ArsC), which catalyzes the glutathione (GSH)-coupled electrochemical reduction of arsenate to the more toxic arsenite.	arsenite	168-176	Arsenate reductase	Escherichia coli	59-63
12270680-4	2002	We report that Ahp1p protects yeast against toxicity induced by copper, cobalt, chromium, arsenite, arsenate, mercury, zinc and diethyl maleate, suggesting that Ahp1p plays an important role in S. cerevisiae in the protection against metals possibly by reducing peroxides generated in cells by these compounds.	arsenite	90-98	thioredoxin peroxidase AHP1	Saccharomyces cerevisiae S288C	15-20
12270680-4	2002	We report that Ahp1p protects yeast against toxicity induced by copper, cobalt, chromium, arsenite, arsenate, mercury, zinc and diethyl maleate, suggesting that Ahp1p plays an important role in S. cerevisiae in the protection against metals possibly by reducing peroxides generated in cells by these compounds.	arsenite	90-98	thioredoxin peroxidase AHP1	Saccharomyces cerevisiae S288C	161-166
12241537-0	2002	Arsenite inhibits interleukin-6 production in human intestinal epithelial cells by down-regulating nuclear factor-kappaB activity.	arsenite	0-8	interleukin 6	Homo sapiens	18-31
12241537-0	2002	Arsenite inhibits interleukin-6 production in human intestinal epithelial cells by down-regulating nuclear factor-kappaB activity.	arsenite	0-8	nuclear factor kappa B subunit 1	Homo sapiens	99-120
12241537-2	2002	We tested the hypothesis that sodium arsenite inhibits IL-6 production in stimulated enterocytes and that this effect of arsenite is caused by down-regulation of NF-kappaB activity.	arsenite	37-45	interleukin 6	Homo sapiens	55-59
12426125-5	2002	Rather, low concentrations of arsenite disrupt p53 function and upregulate cyclin D1.	arsenite	30-38	transformation related protein 53, pseudogene	Mus musculus	47-50
12426125-5	2002	Rather, low concentrations of arsenite disrupt p53 function and upregulate cyclin D1.	arsenite	30-38	cyclin D1	Mus musculus	75-84
12426128-6	2002	Results indicate the term LC(50) for arsenite is approximately 10-15 microM in NHEK and HEL30 keratinocytes and 30 microM in HaCaT keratinocytes.	arsenite	37-45	crystallin lambda 1	Homo sapiens	88-93
12426128-7	2002	Compared with HaCaT and HEL30 keratinocytes, a nontoxic concentration of arsenite (2.5 microM) increases stk25 and nad(p)h quinone oxidoreductase gene expression in NHEK, an effect partially attenuated by BSO.	arsenite	73-81	crystallin lambda 1	Homo sapiens	24-29
12426127-5	2002	Arsenite induces phosphorylation of extracellular signal-regulated protein kinases (Erks) and c-Jun NH(2)-terminal kinases (JNKs).	arsenite	0-8	mitogen-activated protein kinase 1	Homo sapiens	84-88
12426127-6	2002	Arsenite-induced Erk activation was markedly inhibited by introduction of dominant-negative Erk2 into cells, whereas expression of dominant-negative Erk2 did not inhibit JNKs or mitogen-activated protein kinase Erk kinase 1/2.	arsenite	0-8	mitogen-activated protein kinase 1	Homo sapiens	17-20
12426128-7	2002	Compared with HaCaT and HEL30 keratinocytes, a nontoxic concentration of arsenite (2.5 microM) increases stk25 and nad(p)h quinone oxidoreductase gene expression in NHEK, an effect partially attenuated by BSO.	arsenite	73-81	serine/threonine kinase 25	Homo sapiens	105-110
12426127-6	2002	Arsenite-induced Erk activation was markedly inhibited by introduction of dominant-negative Erk2 into cells, whereas expression of dominant-negative Erk2 did not inhibit JNKs or mitogen-activated protein kinase Erk kinase 1/2.	arsenite	0-8	mitogen-activated protein kinase 1	Homo sapiens	92-96
12426128-7	2002	Compared with HaCaT and HEL30 keratinocytes, a nontoxic concentration of arsenite (2.5 microM) increases stk25 and nad(p)h quinone oxidoreductase gene expression in NHEK, an effect partially attenuated by BSO.	arsenite	73-81	crystallin zeta	Homo sapiens	123-145
12426128-8	2002	These data indicate that NHEK and HaCaT/HEL30 keratinocytes have similar sensitivities toward arsenite-induced cytotoxicity but unique gene expression responses.	arsenite	94-102	crystallin lambda 1	Homo sapiens	40-45
12426127-6	2002	Arsenite-induced Erk activation was markedly inhibited by introduction of dominant-negative Erk2 into cells, whereas expression of dominant-negative Erk2 did not inhibit JNKs or mitogen-activated protein kinase Erk kinase 1/2.	arsenite	0-8	mitogen-activated protein kinase 1	Homo sapiens	92-95
12426127-7	2002	Furthermore, arsenite-induced cell transformation was blocked in cells expressing dominant-negative Erk2.	arsenite	13-21	mitogen-activated protein kinase 1	Homo sapiens	100-104
12426127-8	2002	In contrast, overexpression of dominant-negative JNK1 increased cell transformation even though it inhibited arsenite-induced JNK activation.	arsenite	109-117	mitogen-activated protein kinase 8	Homo sapiens	49-53
12426127-8	2002	In contrast, overexpression of dominant-negative JNK1 increased cell transformation even though it inhibited arsenite-induced JNK activation.	arsenite	109-117	mitogen-activated protein kinase 8	Homo sapiens	49-52
12392964-4	2002	Expression of the inflammatory mediator cyclooxygenase-2 (COX-2) was also upregulated in response to arsenite exposure as demonstrated by Western blot analysis.	arsenite	101-109	prostaglandin-endoperoxide synthase 2	Bos taurus	40-56
12392964-4	2002	Expression of the inflammatory mediator cyclooxygenase-2 (COX-2) was also upregulated in response to arsenite exposure as demonstrated by Western blot analysis.	arsenite	101-109	prostaglandin-endoperoxide synthase 2	Bos taurus	58-63
12208374-0	2002	Involvement of reactive oxygen species in arsenite-induced downregulation of phospholipid hydroperoxide glutathione peroxidase in human epidermoid carcinoma A431 cells.	arsenite	42-50	glutathione peroxidase 4	Homo sapiens	77-126
12220541-0	2002	Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite.	arsenite	96-104	heme oxygenase 1	Mus musculus	71-87
12220541-1	2002	The mechanism of heme oxygenase-1 (ho-1) gene activation by arsenite was examined.	arsenite	60-68	heme oxygenase 1	Mus musculus	17-33
12220541-1	2002	The mechanism of heme oxygenase-1 (ho-1) gene activation by arsenite was examined.	arsenite	60-68	heme oxygenase 1	Mus musculus	35-39
12220541-2	2002	Arsenite-stimulated expression of a ho-1 promoter/luciferase chimera in a dose-dependent manner in mouse hepatoma (Hepa) cells.	arsenite	0-8	heme oxygenase 1	Mus musculus	36-40
12220541-5	2002	Antibody "supershift" experiments identified Nrf2, JunD, and ATF3 in control complexes and the amount of these factors increased significantly in the arsenite-induced complex.	arsenite	150-158	nuclear factor, erythroid derived 2, like 2	Mus musculus	45-49
12220541-5	2002	Antibody "supershift" experiments identified Nrf2, JunD, and ATF3 in control complexes and the amount of these factors increased significantly in the arsenite-induced complex.	arsenite	150-158	jun D proto-oncogene	Mus musculus	51-55
12220541-6	2002	MafG, ATF2, FosB, and JunB were also detected in the arsenite complex.	arsenite	53-61	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)	Mus musculus	0-4
12220541-6	2002	MafG, ATF2, FosB, and JunB were also detected in the arsenite complex.	arsenite	53-61	activating transcription factor 2	Mus musculus	6-10
12220541-6	2002	MafG, ATF2, FosB, and JunB were also detected in the arsenite complex.	arsenite	53-61	FBJ osteosarcoma oncogene B	Mus musculus	12-16
12220541-6	2002	MafG, ATF2, FosB, and JunB were also detected in the arsenite complex.	arsenite	53-61	jun B proto-oncogene	Mus musculus	22-26
12220541-7	2002	Activation of a StRE-dependent luciferase gene by arsenite was inhibited to varying degrees by dominant-negative mutants of Nrf2, MafK, c-Fos, and CREB but most strongly with the latter.	arsenite	50-58	nuclear factor, erythroid derived 2, like 2	Mus musculus	124-128
12220541-7	2002	Activation of a StRE-dependent luciferase gene by arsenite was inhibited to varying degrees by dominant-negative mutants of Nrf2, MafK, c-Fos, and CREB but most strongly with the latter.	arsenite	50-58	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)	Mus musculus	130-134
12220541-7	2002	Activation of a StRE-dependent luciferase gene by arsenite was inhibited to varying degrees by dominant-negative mutants of Nrf2, MafK, c-Fos, and CREB but most strongly with the latter.	arsenite	50-58	FBJ osteosarcoma oncogene	Mus musculus	136-141
12220541-7	2002	Activation of a StRE-dependent luciferase gene by arsenite was inhibited to varying degrees by dominant-negative mutants of Nrf2, MafK, c-Fos, and CREB but most strongly with the latter.	arsenite	50-58	cAMP responsive element binding protein 1	Mus musculus	147-151
12220541-8	2002	Together, these results implicate multiple basic-leucine zipper transcription factors in ho-1 gene activation by arsenite.	arsenite	113-121	heme oxygenase 1	Mus musculus	89-93
11985496-5	2002	Endogenous PACT acts as an activator of PKR in response to diverse stress signals, such as serum starvation and peroxide or arsenite treatment, and is therefore a novel, stress-modulated physiological activator of PKR.	arsenite	124-132	protein activator of interferon induced protein kinase EIF2AK2	Homo sapiens	11-15
11985496-5	2002	Endogenous PACT acts as an activator of PKR in response to diverse stress signals, such as serum starvation and peroxide or arsenite treatment, and is therefore a novel, stress-modulated physiological activator of PKR.	arsenite	124-132	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	40-43
12225878-2	2002	The effect of arsenite exposure on cell viability, protein synthesis, energy metabolism and the expression of genes coding for cytoplasmic (hsp70) and endoplasmic reticulum (ER; gadd153, grp78, grp94) stress proteins was investigated in primary neuronal cell cultures.	arsenite	14-22	heat shock protein family A (Hsp70) member 4	Homo sapiens	140-145
12225878-6	2002	Arsenite induced a transient inhibition of energy metabolism after 1 h of exposure, but energy state recovered completely after 3 h. Arsenite exposure affected the expression and translation of genes coding for HSP70 and GRP78, GRP94, GADD153 to different extents.	arsenite	0-8	heat shock protein family A (Hsp70) member 4	Homo sapiens	211-216
12225878-6	2002	Arsenite induced a transient inhibition of energy metabolism after 1 h of exposure, but energy state recovered completely after 3 h. Arsenite exposure affected the expression and translation of genes coding for HSP70 and GRP78, GRP94, GADD153 to different extents.	arsenite	0-8	heat shock protein family A (Hsp70) member 5	Homo sapiens	221-226
12225878-6	2002	Arsenite induced a transient inhibition of energy metabolism after 1 h of exposure, but energy state recovered completely after 3 h. Arsenite exposure affected the expression and translation of genes coding for HSP70 and GRP78, GRP94, GADD153 to different extents.	arsenite	0-8	heat shock protein 90 beta family member 1	Homo sapiens	228-233
12225878-6	2002	Arsenite induced a transient inhibition of energy metabolism after 1 h of exposure, but energy state recovered completely after 3 h. Arsenite exposure affected the expression and translation of genes coding for HSP70 and GRP78, GRP94, GADD153 to different extents.	arsenite	0-8	DNA damage inducible transcript 3	Homo sapiens	235-242
12225878-6	2002	Arsenite induced a transient inhibition of energy metabolism after 1 h of exposure, but energy state recovered completely after 3 h. Arsenite exposure affected the expression and translation of genes coding for HSP70 and GRP78, GRP94, GADD153 to different extents.	arsenite	133-141	heat shock protein family A (Hsp70) member 4	Homo sapiens	211-216
12225878-6	2002	Arsenite induced a transient inhibition of energy metabolism after 1 h of exposure, but energy state recovered completely after 3 h. Arsenite exposure affected the expression and translation of genes coding for HSP70 and GRP78, GRP94, GADD153 to different extents.	arsenite	133-141	heat shock protein family A (Hsp70) member 5	Homo sapiens	221-226
12225878-6	2002	Arsenite induced a transient inhibition of energy metabolism after 1 h of exposure, but energy state recovered completely after 3 h. Arsenite exposure affected the expression and translation of genes coding for HSP70 and GRP78, GRP94, GADD153 to different extents.	arsenite	133-141	heat shock protein 90 beta family member 1	Homo sapiens	228-233
12225878-6	2002	Arsenite induced a transient inhibition of energy metabolism after 1 h of exposure, but energy state recovered completely after 3 h. Arsenite exposure affected the expression and translation of genes coding for HSP70 and GRP78, GRP94, GADD153 to different extents.	arsenite	133-141	DNA damage inducible transcript 3	Homo sapiens	235-242
12208374-7	2002	Overexpression of PHGPx prevented arsenite-induced increase of intracellular peroxide levels, downregulation of PHGPx, upregulation of p21(WAF1/CIP1), and apoptosis in A431 cells.	arsenite	34-42	glutathione peroxidase 4	Homo sapiens	18-23
12208374-7	2002	Overexpression of PHGPx prevented arsenite-induced increase of intracellular peroxide levels, downregulation of PHGPx, upregulation of p21(WAF1/CIP1), and apoptosis in A431 cells.	arsenite	34-42	glutathione peroxidase 4	Homo sapiens	112-117
12208374-7	2002	Overexpression of PHGPx prevented arsenite-induced increase of intracellular peroxide levels, downregulation of PHGPx, upregulation of p21(WAF1/CIP1), and apoptosis in A431 cells.	arsenite	34-42	cyclin dependent kinase inhibitor 1A	Homo sapiens	135-138
12208374-7	2002	Overexpression of PHGPx prevented arsenite-induced increase of intracellular peroxide levels, downregulation of PHGPx, upregulation of p21(WAF1/CIP1), and apoptosis in A431 cells.	arsenite	34-42	cyclin dependent kinase inhibitor 1A	Homo sapiens	139-143
12208374-7	2002	Overexpression of PHGPx prevented arsenite-induced increase of intracellular peroxide levels, downregulation of PHGPx, upregulation of p21(WAF1/CIP1), and apoptosis in A431 cells.	arsenite	34-42	cyclin dependent kinase inhibitor 1A	Homo sapiens	144-148
12208374-9	2002	Therefore, we concluded that reactive oxygen species were involved in arsenite-induced downregulation of PHGPx, upregulation of p21(WAF1/CIP1), and apoptosis in A431 cells.	arsenite	70-78	glutathione peroxidase 4	Homo sapiens	105-110
12208374-9	2002	Therefore, we concluded that reactive oxygen species were involved in arsenite-induced downregulation of PHGPx, upregulation of p21(WAF1/CIP1), and apoptosis in A431 cells.	arsenite	70-78	cyclin dependent kinase inhibitor 1A	Homo sapiens	128-131
12208374-9	2002	Therefore, we concluded that reactive oxygen species were involved in arsenite-induced downregulation of PHGPx, upregulation of p21(WAF1/CIP1), and apoptosis in A431 cells.	arsenite	70-78	cyclin dependent kinase inhibitor 1A	Homo sapiens	132-136
12208374-9	2002	Therefore, we concluded that reactive oxygen species were involved in arsenite-induced downregulation of PHGPx, upregulation of p21(WAF1/CIP1), and apoptosis in A431 cells.	arsenite	70-78	cyclin dependent kinase inhibitor 1A	Homo sapiens	137-141
12122434-0	2002	Resistance to arsenite modulates expression of beta- and gamma-tubulin and sensitivity to paclitaxel during differentiation of Leishmania donovani.	arsenite	14-22	beta tubulin	Leishmania donovani	47-70
12122434-3	2002	In this study, beta- and gamma-tubulin expression under various stages of differentiation was measured in an in vitro generated arsenite-resistant L. donovani strain.	arsenite	128-136	beta tubulin	Leishmania donovani	15-38
12122434-8	2002	Data suggest that the beta- and gamma-tubulin expression and the response to paclitaxel is affected due to arsenite resistance.	arsenite	107-115	beta tubulin	Leishmania donovani	22-45
11983707-6	2002	The essential role of the p38 and JNK stress pathways in up-regulation of VDR expression is further confirmed by using the chemical stimulator arsenite.	arsenite	143-151	mitogen-activated protein kinase 14	Homo sapiens	26-29
11983707-6	2002	The essential role of the p38 and JNK stress pathways in up-regulation of VDR expression is further confirmed by using the chemical stimulator arsenite.	arsenite	143-151	mitogen-activated protein kinase 8	Homo sapiens	34-37
11983707-6	2002	The essential role of the p38 and JNK stress pathways in up-regulation of VDR expression is further confirmed by using the chemical stimulator arsenite.	arsenite	143-151	vitamin D receptor	Homo sapiens	74-77
12161171-0	2002	Differential activation of ERK and JNK by arsenite in mouse muscle cells.	arsenite	42-50	mitogen-activated protein kinase 8	Mus musculus	35-38
12114568-8	2002	In contrast, under arsenite induction, proximal sequences induce AtHsp90-1 gene expression only in the shoot meristem.	arsenite	19-27	heat shock-like protein	Arabidopsis thaliana	65-74
12161171-1	2002	We studied the activation of MAPKs, such as ERK and JNK, by arsenite in C2C12 mouse skeletal muscle cells as a function of proliferation and differentiation.	arsenite	60-68	mitogen-activated protein kinase 1	Mus musculus	44-47
12161171-1	2002	We studied the activation of MAPKs, such as ERK and JNK, by arsenite in C2C12 mouse skeletal muscle cells as a function of proliferation and differentiation.	arsenite	60-68	mitogen-activated protein kinase 8	Mus musculus	52-55
12161171-2	2002	Data showed that both ERK and JNK were activated by arsenite in proliferated and differentiated cells in a differential manner.	arsenite	52-60	mitogen-activated protein kinase 1	Mus musculus	22-25
12161171-2	2002	Data showed that both ERK and JNK were activated by arsenite in proliferated and differentiated cells in a differential manner.	arsenite	52-60	mitogen-activated protein kinase 8	Mus musculus	30-33
12075113-0	2002	Differential activation of the c-Jun N-terminal kinase pathway in arsenite-induced apoptosis and sensitization of chemically resistant compared to susceptible B-lymphoma cell lines.	arsenite	66-74	mitogen-activated protein kinase 8	Homo sapiens	31-54
12075113-7	2002	Importantly, we found that EW36 cells, which overexpress the Bcl-2 protein, can be substantially sensitized to arsenite-induced apoptosis by prior exposure to nonlethal hyperthermia.	arsenite	111-119	BCL2 apoptosis regulator	Homo sapiens	61-66
12075113-10	2002	Significantly, the sensitization of resistant cells is characterized by a lowering of the threshold concentration of arsenite required to activate the JNK pathway and induce apoptosis.	arsenite	117-125	mitogen-activated protein kinase 8	Homo sapiens	151-154
12034312-5	2002	We find that exposure of mouse hepatoma Hepa-1 cells to low concentrations of arsenite increases BaP-DNA adduct levels by as much as 18-fold.	arsenite	78-86	prohibitin 2	Mus musculus	97-100
12161171-0	2002	Differential activation of ERK and JNK by arsenite in mouse muscle cells.	arsenite	42-50	mitogen-activated protein kinase 1	Mus musculus	27-30
12034312-6	2002	This effect requires the activation of BaP by cytochrome p450 1A1 (CYP1A1), although arsenite does not alter BaP-inducible CYP1A1 enzymatic activity, suggesting that arsenite acts downstream of metabolic BaP activation.	arsenite	166-174	prohibitin 2	Mus musculus	39-42
12034312-6	2002	This effect requires the activation of BaP by cytochrome p450 1A1 (CYP1A1), although arsenite does not alter BaP-inducible CYP1A1 enzymatic activity, suggesting that arsenite acts downstream of metabolic BaP activation.	arsenite	166-174	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	46-65
12034312-6	2002	This effect requires the activation of BaP by cytochrome p450 1A1 (CYP1A1), although arsenite does not alter BaP-inducible CYP1A1 enzymatic activity, suggesting that arsenite acts downstream of metabolic BaP activation.	arsenite	166-174	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	67-73
12034312-8	2002	In cells depleted of reduced glutathione, arsenite increased BaP-DNA adduct formation by an even greater degree than in cells co-treated with BaP and arsenite in control medium.	arsenite	42-50	prohibitin 2	Mus musculus	61-64
12034312-10	2002	Concentrations of arsenite and BaP that had no measurable mutagenic effect alone, increased mutation frequency at the Hprt locus by eight-fold when given in combination, demonstrating a comutagenic response between BaP and arsenite.	arsenite	18-26	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	118-122
12034312-10	2002	Concentrations of arsenite and BaP that had no measurable mutagenic effect alone, increased mutation frequency at the Hprt locus by eight-fold when given in combination, demonstrating a comutagenic response between BaP and arsenite.	arsenite	18-26	prohibitin 2	Mus musculus	215-218
12034312-10	2002	Concentrations of arsenite and BaP that had no measurable mutagenic effect alone, increased mutation frequency at the Hprt locus by eight-fold when given in combination, demonstrating a comutagenic response between BaP and arsenite.	arsenite	223-231	prohibitin 2	Mus musculus	31-34
12018983-7	2002	Arsenite cytotoxicity increased markedly when cellular GSH was depleted with the glutathione synthase inhibitor, L-buthionine-[S,R]-sulfoximine (BSO).	arsenite	0-8	glutathione synthetase	Homo sapiens	81-101
12162448-4	2002	Concurrent treatment of cells with either superoxide dismutase or catalase reduced both the cytotoxicity and mutagenicity of arsenite by an average of 2-3 fold, respectively.	arsenite	125-133	catalase	Homo sapiens	66-74
11948422-4	2002	Both anisomycin and arsenite activate the JNK pathway and, in addition, inactivate the M3/6 phosphatase.	arsenite	20-28	mitogen-activated protein kinase 8	Homo sapiens	42-45
12034312-10	2002	Concentrations of arsenite and BaP that had no measurable mutagenic effect alone, increased mutation frequency at the Hprt locus by eight-fold when given in combination, demonstrating a comutagenic response between BaP and arsenite.	arsenite	223-231	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	118-122
11993874-6	2002	At high As(III) or As(V) concentrations, arsenate or arsenite species form, probably as sorption complexes, along with poorly crystalline arsenic sulfide (the only product at low As(V) concentrations).	arsenite	53-61	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	19-24
11790780-5	2002	Reverse transcription-polymerase chain reaction detects S-adenosyl-l-methionine:arsenic(III) methyltransferase mRNA in rat tissues and in HepG2 cells, a human cell line that methylates arsenite and methylarsonous acid.	arsenite	185-193	arsenite methyltransferase	Rattus norvegicus	56-110
11836020-1	2002	In the present study, we investigated the inducibility of the drug conjugate transporter genes MRP1 and MRP2 by redox-active compounds such as tertiary butylated hydroquinone (tBHQ) and quercetin and by chemicals known to activate the pregnane X receptor (PXR) such as rifampicin and clotrimazol and by the metalloid compound arsenite.	arsenite	326-334	ATP binding cassette subfamily C member 1	Homo sapiens	95-99
11855834-4	2002	These observations further demonstrate that glutathione is an important component of MRP1-mediated cellular resistance to arsenite and antimony.	arsenite	122-130	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	85-89
11854143-0	2002	Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[a]pyrene is diminished by arsenite.	arsenite	101-109	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-19
11854143-0	2002	Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[a]pyrene is diminished by arsenite.	arsenite	101-109	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	24-30
11854143-8	2002	These results indicate a post-transcriptional inhibitory effect of arsenite on the expression of CYP1A1 and CYP1B1 in T-47D cells, possibly resulting from reduced heme availability.	arsenite	67-75	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	97-103
11854143-8	2002	These results indicate a post-transcriptional inhibitory effect of arsenite on the expression of CYP1A1 and CYP1B1 in T-47D cells, possibly resulting from reduced heme availability.	arsenite	67-75	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	108-114
11972053-0	2002	Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9.	arsenite	0-8	aquaporin 7	Homo sapiens	50-54
11972053-0	2002	Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9.	arsenite	0-8	aquaporin 9	Homo sapiens	59-63
11972053-4	2002	Fps1p has been shown to facilitate uptake of the metalloids arsenite and antimonite, and the Escherichia coli homolog, GlpF, facilitates the uptake and sensitivity to metalloid salts.	arsenite	60-68	Fps1p	Saccharomyces cerevisiae S288C	0-5
11972053-11	2002	These results suggest that AQP9 and AQP7 may be a major routes of arsenite uptake into mammalian cells, an observation potentially of large importance for understanding the action of arsenite as a human toxin and carcinogen, as well as its efficacy as a chemotherapeutic agent for acute promyelocytic leukemia.	arsenite	66-74	aquaporin 9	Homo sapiens	27-31
11972053-11	2002	These results suggest that AQP9 and AQP7 may be a major routes of arsenite uptake into mammalian cells, an observation potentially of large importance for understanding the action of arsenite as a human toxin and carcinogen, as well as its efficacy as a chemotherapeutic agent for acute promyelocytic leukemia.	arsenite	66-74	aquaporin 7	Homo sapiens	36-40
11972053-11	2002	These results suggest that AQP9 and AQP7 may be a major routes of arsenite uptake into mammalian cells, an observation potentially of large importance for understanding the action of arsenite as a human toxin and carcinogen, as well as its efficacy as a chemotherapeutic agent for acute promyelocytic leukemia.	arsenite	183-191	aquaporin 9	Homo sapiens	27-31
11972053-11	2002	These results suggest that AQP9 and AQP7 may be a major routes of arsenite uptake into mammalian cells, an observation potentially of large importance for understanding the action of arsenite as a human toxin and carcinogen, as well as its efficacy as a chemotherapeutic agent for acute promyelocytic leukemia.	arsenite	183-191	aquaporin 7	Homo sapiens	36-40
11836020-1	2002	In the present study, we investigated the inducibility of the drug conjugate transporter genes MRP1 and MRP2 by redox-active compounds such as tertiary butylated hydroquinone (tBHQ) and quercetin and by chemicals known to activate the pregnane X receptor (PXR) such as rifampicin and clotrimazol and by the metalloid compound arsenite.	arsenite	326-334	synaptonemal complex central element protein 1 like	Homo sapiens	104-108
11836020-2	2002	The human MRP2 gene was found to be inducible in HepG2 cells by rifampicin, clotrimazol, arsenite and tBHQ.	arsenite	89-97	synaptonemal complex central element protein 1 like	Homo sapiens	10-14
11842186-0	2002	Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway.	arsenite	0-8	cell division cycle 25C	Homo sapiens	17-23
11842186-4	2002	Analysis of cell cycle profile and cell cycle regulatory proteins indicated that arsenite arrested the cell cycle at G(2)/M phase, partially through induction of cell division cycle 25 (Cdc25) isoform C (Cdc25C) degradation via ubiquitin-proteasome pathways.	arsenite	81-89	cell division cycle 25C	Homo sapiens	186-191
11842186-4	2002	Analysis of cell cycle profile and cell cycle regulatory proteins indicated that arsenite arrested the cell cycle at G(2)/M phase, partially through induction of cell division cycle 25 (Cdc25) isoform C (Cdc25C) degradation via ubiquitin-proteasome pathways.	arsenite	81-89	cell division cycle 25C	Homo sapiens	204-210
11842186-5	2002	Mutation of the putative KEN box within the region 151 to 157 of human Cdc25C or treatment of the cells with a peptide competitor encompassing the KEN box partially inhibited arsenite-induced ubiquitination of Cdc25C.	arsenite	175-183	cell division cycle 25C	Homo sapiens	71-77
11842186-5	2002	Mutation of the putative KEN box within the region 151 to 157 of human Cdc25C or treatment of the cells with a peptide competitor encompassing the KEN box partially inhibited arsenite-induced ubiquitination of Cdc25C.	arsenite	175-183	cell division cycle 25C	Homo sapiens	210-216
11842186-6	2002	Thus, these results indicate that the regulated ubiquitination of Cdc25C may be involved in the arsenite-induced proteolytic down-regulation of Cdc25C activity in the G(2)/M phase of the cell cycle and suggest a link between cell cycle and the carcinogenic effects of arsenite.	arsenite	96-104	cell division cycle 25C	Homo sapiens	66-72
11842186-6	2002	Thus, these results indicate that the regulated ubiquitination of Cdc25C may be involved in the arsenite-induced proteolytic down-regulation of Cdc25C activity in the G(2)/M phase of the cell cycle and suggest a link between cell cycle and the carcinogenic effects of arsenite.	arsenite	96-104	cell division cycle 25C	Homo sapiens	144-150
11842186-6	2002	Thus, these results indicate that the regulated ubiquitination of Cdc25C may be involved in the arsenite-induced proteolytic down-regulation of Cdc25C activity in the G(2)/M phase of the cell cycle and suggest a link between cell cycle and the carcinogenic effects of arsenite.	arsenite	268-276	cell division cycle 25C	Homo sapiens	66-72
11842186-6	2002	Thus, these results indicate that the regulated ubiquitination of Cdc25C may be involved in the arsenite-induced proteolytic down-regulation of Cdc25C activity in the G(2)/M phase of the cell cycle and suggest a link between cell cycle and the carcinogenic effects of arsenite.	arsenite	268-276	cell division cycle 25C	Homo sapiens	144-150
11911489-0	2002	Arsenite pretreatment attenuates benzo[a]pyrene cytotoxicity in a human lung adenocarcinoma cell line by decreasing cyclooxygenase-2 levels.	arsenite	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	116-132
11911489-1	2002	Both simultaneous and sequential exposure to arsenite and benzo[a]pyrene (BaP) potentially occur in human populations drinking arsenic-contaminated water or burning arsenic-contaminated coal.	arsenite	45-53	prohibitin 2	Homo sapiens	74-77
11911489-3	2002	In this study, we demonstrated that posttreatment with arsenite synergistically enhanced the cytotoxicity of BaP for a human lung adenocarcinoma cell line, CL3.	arsenite	55-63	prohibitin 2	Homo sapiens	109-112
11862762-3	2002	Chemical stress by sodium arsenite (arsenite) induces HSP27 coupled to the metabolic activity of the arachidonic acid cascade, and the HSP27 induction by arsenite is negatively regulated by activation of protein kinase C (PKC).	arsenite	26-34	heat shock protein family B (small) member 1	Homo sapiens	54-59
11862762-3	2002	Chemical stress by sodium arsenite (arsenite) induces HSP27 coupled to the metabolic activity of the arachidonic acid cascade, and the HSP27 induction by arsenite is negatively regulated by activation of protein kinase C (PKC).	arsenite	36-44	heat shock protein family B (small) member 1	Homo sapiens	54-59
11750083-7	2002	The mdr1a/1b(-/-) mice were more sensitive than wild-type mice to arsenite-induced lethality, with LD(50) of 14.5 and 17 mg/kg, respectively.	arsenite	66-74	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	4-9
11750083-8	2002	Histologically, arsenite produced more frequent and more severe lesions in the liver and kidney of the mdr1a/1b(-/-) mice than in wild-type mice.	arsenite	16-24	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	103-108
11756236-6	2002	Ro318220, a strong activator of JNK, enhanced arsenite-induced apoptosis in transformed cells.	arsenite	46-54	mitogen-activated protein kinase 8	Rattus norvegicus	32-35
11807808-5	2002	In addition, arsenite induced CDK inhibitor p21(CIP1/WAF1) and enhanced its binding to the CDK2, which resulted in inhibition of CDK2 activity.	arsenite	13-21	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	44-47
11807808-5	2002	In addition, arsenite induced CDK inhibitor p21(CIP1/WAF1) and enhanced its binding to the CDK2, which resulted in inhibition of CDK2 activity.	arsenite	13-21	cyclin-dependent kinase 2	Mus musculus	91-95
11807808-5	2002	In addition, arsenite induced CDK inhibitor p21(CIP1/WAF1) and enhanced its binding to the CDK2, which resulted in inhibition of CDK2 activity.	arsenite	13-21	cyclin-dependent kinase 2	Mus musculus	129-133
11807808-8	2002	SB203580, a specific inhibitor of p38MAPK, blocked arsenite-induced growth inhibition as well as the arsenite-induced p21(CIP1/WAF1) expression.	arsenite	51-59	mitogen-activated protein kinase 14	Mus musculus	34-41
11807808-8	2002	SB203580, a specific inhibitor of p38MAPK, blocked arsenite-induced growth inhibition as well as the arsenite-induced p21(CIP1/WAF1) expression.	arsenite	101-109	mitogen-activated protein kinase 14	Mus musculus	34-41
11807808-8	2002	SB203580, a specific inhibitor of p38MAPK, blocked arsenite-induced growth inhibition as well as the arsenite-induced p21(CIP1/WAF1) expression.	arsenite	101-109	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	118-121
11807808-9	2002	Expression of dominant negative p38MAPK also blocked arsenite-induced p21(CIP1/WAF1) expression.	arsenite	53-61	mitogen-activated protein kinase 14	Mus musculus	32-39
11807808-9	2002	Expression of dominant negative p38MAPK also blocked arsenite-induced p21(CIP1/WAF1) expression.	arsenite	53-61	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	70-73
11835400-0	2002	Arsenite stimulates cyclooxygenase-2 expression through activating IkappaB kinase and nuclear factor kappaB in primary and ECV304 endothelial cells.	arsenite	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	20-36
11835400-3	2002	However, the effect of arsenite on Cox-2 gene expression in endothelial cells was left to be investigated.	arsenite	23-31	prostaglandin-endoperoxide synthase 2	Homo sapiens	35-40
11835400-4	2002	Western Blot analysis of HUVECs revealed a two-fold induction of Cox-2 protein by arsenite.	arsenite	82-90	prostaglandin-endoperoxide synthase 2	Homo sapiens	65-70
11835400-7	2002	Transfection of an immortalized human endothelium cell line (ECV304) with Cox-2 reporter gene constructs demonstrated that the transcription of Cox-2 gene was enhanced by arsenite.	arsenite	171-179	prostaglandin-endoperoxide synthase 2	Homo sapiens	74-79
11835400-7	2002	Transfection of an immortalized human endothelium cell line (ECV304) with Cox-2 reporter gene constructs demonstrated that the transcription of Cox-2 gene was enhanced by arsenite.	arsenite	171-179	prostaglandin-endoperoxide synthase 2	Homo sapiens	144-149
11835400-9	2002	In addition, electrophoretic mobility shift assays indicated that NFkappaB activity was induced by arsenite.	arsenite	99-107	nuclear factor kappa B subunit 1	Homo sapiens	66-74
11835400-11	2002	These findings indicated that the induction of Cox-2 gene transcription by arsenite was through the stimulation of NFkappaB activity.	arsenite	75-83	prostaglandin-endoperoxide synthase 2	Homo sapiens	47-52
11835400-11	2002	These findings indicated that the induction of Cox-2 gene transcription by arsenite was through the stimulation of NFkappaB activity.	arsenite	75-83	nuclear factor kappa B subunit 1	Homo sapiens	115-123
11884240-3	2002	Trivalent inorganic arsenic (arsenite) induced in vitro aggregation when platelets were exposed to subthreshold challenge by thrombin and several other agonists in a concentration-dependent manner, with arsenite being the most potent form tested.	arsenite	29-37	coagulation factor II, thrombin	Homo sapiens	125-133
11884240-3	2002	Trivalent inorganic arsenic (arsenite) induced in vitro aggregation when platelets were exposed to subthreshold challenge by thrombin and several other agonists in a concentration-dependent manner, with arsenite being the most potent form tested.	arsenite	203-211	coagulation factor II, thrombin	Homo sapiens	125-133
12489113-0	2002	Effects of heat shock protein 70 (Hsp70) on arsenite-induced genotoxicity.	arsenite	44-52	heat shock protein family A (Hsp70) member 4	Homo sapiens	11-32
12489113-0	2002	Effects of heat shock protein 70 (Hsp70) on arsenite-induced genotoxicity.	arsenite	44-52	heat shock protein family A (Hsp70) member 4	Homo sapiens	34-39
12489113-3	2002	In the present study, we evaluated the effects of Hsp70 expression on arsenite (As)-induced structural and numerical chromosome anomalies in human cells.	arsenite	70-78	heat shock protein family A (Hsp70) member 4	Homo sapiens	50-55
12489113-3	2002	In the present study, we evaluated the effects of Hsp70 expression on arsenite (As)-induced structural and numerical chromosome anomalies in human cells.	arsenite	80-82	heat shock protein family A (Hsp70) member 4	Homo sapiens	50-55
12489113-10	2002	Both K+ and K- types of As-induced MN were lower in cells with elevated Hsp70 as compared to cells without overexpression of Hsp70.	arsenite	24-26	heat shock protein family A (Hsp70) member 4	Homo sapiens	72-77
12489113-10	2002	Both K+ and K- types of As-induced MN were lower in cells with elevated Hsp70 as compared to cells without overexpression of Hsp70.	arsenite	24-26	heat shock protein family A (Hsp70) member 4	Homo sapiens	125-130
11862551-1	2002	Arsenate reductase (ArsC) encoded by Staphylococcus aureus arsenic-resistance plasmid pI258 reduces intracellular arsenate(V) to the more toxic arsenite(III), which is subsequently extruded from the cell.	arsenite	144-152	Arsenate reductase	Staphylococcus aureus	0-18
11862551-1	2002	Arsenate reductase (ArsC) encoded by Staphylococcus aureus arsenic-resistance plasmid pI258 reduces intracellular arsenate(V) to the more toxic arsenite(III), which is subsequently extruded from the cell.	arsenite	144-152	Arsenate reductase	Staphylococcus aureus	20-24
11862551-8	2002	Under these new conditions and in contrast to previous observations, ArsC has a high substrate specificity, as only arsenate could be reduced ( Km=68 microM, k(cat)/ Km =5.2 x 10(4 )M-1s-1), while its product, arsenite, was identified as a mixed inhibitor ( K*iu=534 microM, K*ic=377 microM).	arsenite	210-218	Arsenate reductase	Staphylococcus aureus	69-73
11813266-5	2002	P53, p21, and MDM2 were induced in E6-transfected TK6 cells, as well as in parental TK6 cells after arsenite treatment.	arsenite	100-108	tumor protein p53	Homo sapiens	0-3
11813266-5	2002	P53, p21, and MDM2 were induced in E6-transfected TK6 cells, as well as in parental TK6 cells after arsenite treatment.	arsenite	100-108	H3 histone pseudogene 16	Homo sapiens	5-8
11813266-5	2002	P53, p21, and MDM2 were induced in E6-transfected TK6 cells, as well as in parental TK6 cells after arsenite treatment.	arsenite	100-108	MDM2 proto-oncogene	Homo sapiens	14-18
11813266-7	2002	It indicated that arsenite, but not X-ray, could suppress the transcription of E6 gene and therefore activate the p53 tumor suppressor pathway in TK6-E6 cells.	arsenite	18-26	tumor protein p53	Homo sapiens	114-117
11813266-8	2002	After arsenite treatment, TK6-E6 cells showed more sub-G1 apoptosis, activated caspase-3/CPP32 fragment, DNA ladder, and less viability than parental TK6 cells, indicating that arsenite enhanced apoptosis in E6-transfected TK6 cells.	arsenite	177-185	caspase 3	Homo sapiens	79-88
11813266-8	2002	After arsenite treatment, TK6-E6 cells showed more sub-G1 apoptosis, activated caspase-3/CPP32 fragment, DNA ladder, and less viability than parental TK6 cells, indicating that arsenite enhanced apoptosis in E6-transfected TK6 cells.	arsenite	177-185	caspase 3	Homo sapiens	89-94
11835394-0	2002	Arsenite stabilizes IkappaBalpha and prevents NF-kappaB activation in IL-1 beta-stimulated Caco-2 cells independent of the heat shock response.	arsenite	0-8	NFKB inhibitor alpha	Homo sapiens	20-32
11835394-0	2002	Arsenite stabilizes IkappaBalpha and prevents NF-kappaB activation in IL-1 beta-stimulated Caco-2 cells independent of the heat shock response.	arsenite	0-8	nuclear factor kappa B subunit 1	Homo sapiens	46-55
11835394-0	2002	Arsenite stabilizes IkappaBalpha and prevents NF-kappaB activation in IL-1 beta-stimulated Caco-2 cells independent of the heat shock response.	arsenite	0-8	interleukin 1 beta	Homo sapiens	70-79
11835394-3	2002	The role of the heat shock response in arsenite-induced inhibition of NF-kappaB, however, is not known.	arsenite	39-47	nuclear factor kappa B subunit 1	Homo sapiens	70-79
11835394-4	2002	We examined the involvement of the heat shock response in arsenite-induced inhibition of NF-kappaB activity in IL-1beta-stimulated Caco-2 cells, a human colorectal adenocarcinoma cell line with enterocytic properties.	arsenite	58-66	nuclear factor kappa B subunit 1	Homo sapiens	89-98
11835394-4	2002	We examined the involvement of the heat shock response in arsenite-induced inhibition of NF-kappaB activity in IL-1beta-stimulated Caco-2 cells, a human colorectal adenocarcinoma cell line with enterocytic properties.	arsenite	58-66	interleukin 1 beta	Homo sapiens	111-119
12210719-5	2002	Exposure of LEC to 5 microM arsenite cause time-dependent increase in gamma-glutamylcysteine synthetase (gamma-GCS) expression.	arsenite	28-36	glutamate-cysteine ligase catalytic subunit	Homo sapiens	70-103
12210719-5	2002	Exposure of LEC to 5 microM arsenite cause time-dependent increase in gamma-glutamylcysteine synthetase (gamma-GCS) expression.	arsenite	28-36	glutamate-cysteine ligase catalytic subunit	Homo sapiens	105-114
11809833-6	2002	Cells expressing a phosphomimetic mutant (S51D) of eIF2alpha assemble SGs of similar composition, confirming that the recruitment of these factors is a direct consequence of blocked translational initiation and not due to other effects of arsenite.	arsenite	239-247	eukaryotic translation initiation factor 2A	Homo sapiens	51-60
11809833-7	2002	Surprisingly, phospho-eIF2alpha is recruited to SGs that are disassembling in cells recovering from arsenite-induced stress.	arsenite	100-108	eukaryotic translation initiation factor 2A	Homo sapiens	22-31
11911489-4	2002	In contrast, pretreatment of CL3 cells with arsenite attenuated BaP cytotoxicity.	arsenite	44-52	prohibitin 2	Mus musculus	64-67
11911489-5	2002	Involvement of heat-shock protein 70 and heme oxygenase-1 in this arsenite-mediated attenuation of BaP cytotoxicity was ruled out.	arsenite	66-74	prohibitin 2	Homo sapiens	99-102
11911489-6	2002	Our data also indicated that arsenite pretreatment did not affect the BaP-mediated induction of CYP1A1, the initial enzyme involved in its metabolic activation, but did result in a significant decrease in mRNA and protein levels of cyclooxygenase-2 (COX-2), which is required to convert the BaP metabolite BaP 7,8-dihydrodiol to the ultimate epoxide.	arsenite	29-37	prostaglandin-endoperoxide synthase 2	Homo sapiens	232-248
11864708-5	2002	Incubation of human microvascular endothelial cells (HMEC-1), but not human umbilical vein endothelial cells (HUVECs), with arsenite caused a decrease of t-PA mRNA level, a rise of both PAI-1 mRNA level and PAI activity.	arsenite	124-132	plasminogen activator, tissue type	Homo sapiens	154-158
11864708-5	2002	Incubation of human microvascular endothelial cells (HMEC-1), but not human umbilical vein endothelial cells (HUVECs), with arsenite caused a decrease of t-PA mRNA level, a rise of both PAI-1 mRNA level and PAI activity.	arsenite	124-132	serpin family E member 1	Homo sapiens	186-191
11864708-6	2002	Arsenite could also inhibit the thrombomodulin (TM) mRNA expression and reduce the TM antigen level in HMEC-1.	arsenite	0-8	thrombomodulin	Homo sapiens	32-46
11641398-0	2001	Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite.	arsenite	129-137	vascular endothelial growth factor A	Homo sapiens	13-47
11641398-0	2001	Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite.	arsenite	129-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	63-94
11641398-2	2001	To investigate whether this is a general phenomenon, we studied the effects of the sulfhydryl reagent arsenite on VEGF expression in human ovarian cancer cells.	arsenite	102-110	vascular endothelial growth factor A	Homo sapiens	114-118
11641398-4	2001	We report that arsenite induces VEGF mRNA and protein levels in normoxic H134 and OVCAR-3 cells.	arsenite	15-23	vascular endothelial growth factor A	Homo sapiens	32-36
11641398-5	2001	Arsenite also increases HIF-1alpha protein levels, suggesting a role for HIF-1 in the induction of VEGF expression.	arsenite	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	24-34
11641398-5	2001	Arsenite also increases HIF-1alpha protein levels, suggesting a role for HIF-1 in the induction of VEGF expression.	arsenite	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	24-29
11641398-5	2001	Arsenite also increases HIF-1alpha protein levels, suggesting a role for HIF-1 in the induction of VEGF expression.	arsenite	0-8	vascular endothelial growth factor A	Homo sapiens	99-103
11641398-8	2001	These results demonstrate that arsenite-induced VEGF mRNA and HIF-1alpha protein expression is independent of increased ROS production but critically regulated by the cellular reduced glutathione content.	arsenite	31-39	vascular endothelial growth factor A	Homo sapiens	48-52
11641398-8	2001	These results demonstrate that arsenite-induced VEGF mRNA and HIF-1alpha protein expression is independent of increased ROS production but critically regulated by the cellular reduced glutathione content.	arsenite	31-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-72
11689689-3	2001	We have demonstrated that HRI in reticulocytes and fetal liver nucleated erythroid progenitors is activated by oxidative stress induced by arsenite, heat shock, and osmotic stress but not by endoplasmic reticulum stress or nutrient starvation.	arsenite	139-147	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	26-29
11689689-6	2001	HRI is the only eIF2alpha kinase activated by arsenite in erythroid cells, since HRI-null cells do not induce eIF2alpha phosphorylation upon arsenite treatment.	arsenite	46-54	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	0-3
11689689-6	2001	HRI is the only eIF2alpha kinase activated by arsenite in erythroid cells, since HRI-null cells do not induce eIF2alpha phosphorylation upon arsenite treatment.	arsenite	46-54	eukaryotic translation initiation factor 2A	Homo sapiens	16-25
11689689-10	2001	However, reactive oxygen species are involved only in HRI activation by arsenite.	arsenite	72-80	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	54-57
11689710-3	2001	Here we show that MKP-1 mRNA was potently induced by arsenite and ultraviolet light and modestly increased by heat shock and hydrogen peroxide.	arsenite	53-61	dual specificity phosphatase 1	Homo sapiens	18-23
11689710-4	2001	Interestingly, arsenite also dramatically induces phosphorylation-acetylation of histone H3 at a global level which precedes the induction of MKP-1 mRNA.	arsenite	15-23	dual specificity phosphatase 1	Homo sapiens	142-147
11689710-5	2001	The transcriptional induction of MKP-1, histone H3 modification, and elevation in MKP-1 mRNA in response to arsenite are all partially prevented by the p38 MAP kinase inhibitor SB203580, suggesting that the p38 pathway is involved in these processes.	arsenite	108-116	dual specificity phosphatase 1	Homo sapiens	33-38
11689710-5	2001	The transcriptional induction of MKP-1, histone H3 modification, and elevation in MKP-1 mRNA in response to arsenite are all partially prevented by the p38 MAP kinase inhibitor SB203580, suggesting that the p38 pathway is involved in these processes.	arsenite	108-116	dual specificity phosphatase 1	Homo sapiens	82-87
11689710-5	2001	The transcriptional induction of MKP-1, histone H3 modification, and elevation in MKP-1 mRNA in response to arsenite are all partially prevented by the p38 MAP kinase inhibitor SB203580, suggesting that the p38 pathway is involved in these processes.	arsenite	108-116	mitogen-activated protein kinase 14	Homo sapiens	152-155
11689710-5	2001	The transcriptional induction of MKP-1, histone H3 modification, and elevation in MKP-1 mRNA in response to arsenite are all partially prevented by the p38 MAP kinase inhibitor SB203580, suggesting that the p38 pathway is involved in these processes.	arsenite	108-116	mitogen-activated protein kinase 14	Homo sapiens	207-210
11689710-6	2001	Finally, analysis of the DNA brought down by chromatin immunoprecipitation (ChIP) reveals that arsenite induces phosphorylation-acetylation of histone H3 associated with the MKP-1 gene and enhances binding of RNA polymerase II to MKP-1 chromatin.	arsenite	95-103	dual specificity phosphatase 1	Homo sapiens	174-179
11689710-6	2001	Finally, analysis of the DNA brought down by chromatin immunoprecipitation (ChIP) reveals that arsenite induces phosphorylation-acetylation of histone H3 associated with the MKP-1 gene and enhances binding of RNA polymerase II to MKP-1 chromatin.	arsenite	95-103	dual specificity phosphatase 1	Homo sapiens	230-235
11753636-4	2001	In a cell-free system, lonidamine, arsenite, and CD437 induced the permeabilization of ANT proteoliposomes, yet had no effect on protein-free liposomes.	arsenite	35-43	solute carrier family 25 member 6	Homo sapiens	87-90
11753636-6	2001	Lonidamine, arsenite, and CD437, added to synthetic planar lipid bilayers containing ANT, elicited ANT channel activities with clearly distinct conductance levels of 20+/-7, 100+/-30, and 47+/-7 pS, respectively.	arsenite	12-20	solute carrier family 25 member 6	Homo sapiens	85-88
11753636-6	2001	Lonidamine, arsenite, and CD437, added to synthetic planar lipid bilayers containing ANT, elicited ANT channel activities with clearly distinct conductance levels of 20+/-7, 100+/-30, and 47+/-7 pS, respectively.	arsenite	12-20	solute carrier family 25 member 6	Homo sapiens	99-102
11753636-9	2001	In contrast, only the combined inhibition of glycolysis plus F(0)F(1)ATPase sensitized to arsenite-induced cell death.	arsenite	90-98	ATP synthase F1 subunit epsilon	Homo sapiens	61-75
11753636-11	2001	These results indicate that ANT is a target of lonidamine, arsenite, and CD437 and unravel an unexpected heterogeneity in the mode of action of these three compounds.	arsenite	59-67	solute carrier family 25 member 6	Homo sapiens	28-31
11485391-3	2001	Four representative differentiation marker mRNAs (involucrin, keratinocyte transglutaminase, small proline-rich protein 1, and filaggrin) were suppressed by both arsenate and arsenite in normal, spontaneously immortalized (premalignant), and malignant keratinocytes with EC50 values in the low micromolar range.	arsenite	175-183	opiorphin prepropeptide	Homo sapiens	99-121
11585900-4	2001	We report here that arsenite is a potent inhibitor of the interaction of SMRT with its transcription factor partners, including PML-RARalpha.	arsenite	20-28	retinoic acid receptor alpha	Homo sapiens	132-140
11585900-5	2001	Arsenite operates, in part, through a mitogen-activated protein (MAP) kinase cascade culminating in phosphorylation of the SMRT protein, dissociation of SMRT from its nuclear receptor partners, and a relocalization of SMRT out of the nucleus into the cytoplasm of the cell.	arsenite	0-8	nuclear receptor corepressor 2	Homo sapiens	123-127
11585900-5	2001	Arsenite operates, in part, through a mitogen-activated protein (MAP) kinase cascade culminating in phosphorylation of the SMRT protein, dissociation of SMRT from its nuclear receptor partners, and a relocalization of SMRT out of the nucleus into the cytoplasm of the cell.	arsenite	0-8	nuclear receptor corepressor 2	Homo sapiens	153-157
11585900-5	2001	Arsenite operates, in part, through a mitogen-activated protein (MAP) kinase cascade culminating in phosphorylation of the SMRT protein, dissociation of SMRT from its nuclear receptor partners, and a relocalization of SMRT out of the nucleus into the cytoplasm of the cell.	arsenite	0-8	nuclear receptor corepressor 2	Homo sapiens	153-157
11585900-7	2001	Our results implicate SMRT as an important biological target for the actions of arsenite in both normal and neoplastic cells.	arsenite	80-88	nuclear receptor corepressor 2	Homo sapiens	22-26
11788791-0	2001	Arsenite activation of P13K/AKT cell survival pathway is mediated by p38 in cultured human keratinocytes.	arsenite	0-8	AKT serine/threonine kinase 1	Homo sapiens	28-31
11788791-0	2001	Arsenite activation of P13K/AKT cell survival pathway is mediated by p38 in cultured human keratinocytes.	arsenite	0-8	mitogen-activated protein kinase 14	Homo sapiens	69-72
11788791-4	2001	The objective of this study was to investigate the pathway leading to the activation of eNOS in response to arsenite using human keratinocytes.	arsenite	108-116	nitric oxide synthase 3	Homo sapiens	88-92
11788791-10	2001	RESULTS: Arsenite induced the activation of AKT at both Ser473 and Thr308, and its downstream effector eNOS in cultured human keratinocytes.	arsenite	9-17	AKT serine/threonine kinase 1	Homo sapiens	44-47
11788791-10	2001	RESULTS: Arsenite induced the activation of AKT at both Ser473 and Thr308, and its downstream effector eNOS in cultured human keratinocytes.	arsenite	9-17	nitric oxide synthase 3	Homo sapiens	103-107
11788791-11	2001	Arsenite also induced phosphorylation of p38.	arsenite	0-8	mitogen-activated protein kinase 14	Homo sapiens	41-44
11574405-12	2001	Arsenite-stimulated import of PDX-1 into the nucleus was inhibited by SB 203580 but not by wortmannin.	arsenite	0-8	pancreatic and duodenal homeobox 1	Homo sapiens	30-35
11573087-1	2001	Arsenate reductase (ArsC) from Staphylococcus aureus plasmid pI258 plays a role in bacterial heavy metal resistance and catalyzes the reduction of arsenate to arsenite.	arsenite	159-167	Arsenate reductase	Staphylococcus aureus	0-18
11573087-1	2001	Arsenate reductase (ArsC) from Staphylococcus aureus plasmid pI258 plays a role in bacterial heavy metal resistance and catalyzes the reduction of arsenate to arsenite.	arsenite	159-167	Arsenate reductase	Staphylococcus aureus	20-24
11461905-1	2001	Acr2p detoxifies arsenate by reduction to arsenite in Saccharomyces cerevisiae.	arsenite	42-50	Arr2p	Saccharomyces cerevisiae S288C	0-5
11835400-13	2002	Therefore, it appears that IKK signaling pathway is involved in arsenite-mediated Cox-2 expression.	arsenite	64-72	prostaglandin-endoperoxide synthase 2	Homo sapiens	82-87
11585900-4	2001	We report here that arsenite is a potent inhibitor of the interaction of SMRT with its transcription factor partners, including PML-RARalpha.	arsenite	20-28	nuclear receptor corepressor 2	Homo sapiens	73-77
11788791-12	2001	PI-3-kinase inhibitors, Wortmannin and LY294002 inhibited arsenite-induced phosphorylation of AKT and eNOS but had no effect on phosphorylation of p38.	arsenite	58-66	AKT serine/threonine kinase 1	Homo sapiens	94-97
11788791-12	2001	PI-3-kinase inhibitors, Wortmannin and LY294002 inhibited arsenite-induced phosphorylation of AKT and eNOS but had no effect on phosphorylation of p38.	arsenite	58-66	nitric oxide synthase 3	Homo sapiens	102-106
11788791-13	2001	Interestingly, however, SB203580, a known p38 inhibitor, completely inhibited arsenite-induced phosphorylation of AKT and eNOS.	arsenite	78-86	mitogen-activated protein kinase 14	Homo sapiens	42-45
11788791-13	2001	Interestingly, however, SB203580, a known p38 inhibitor, completely inhibited arsenite-induced phosphorylation of AKT and eNOS.	arsenite	78-86	AKT serine/threonine kinase 1	Homo sapiens	114-117
11788791-13	2001	Interestingly, however, SB203580, a known p38 inhibitor, completely inhibited arsenite-induced phosphorylation of AKT and eNOS.	arsenite	78-86	nitric oxide synthase 3	Homo sapiens	122-126
11788791-15	2001	CONCLUSIONS: Collectively, our data indicate that arsenite induces activation of AKT and eNOS, via PI-3-kinase and p38 pathway, likely bypassing the activation of EGF receptor in cultured human keratinocytes.	arsenite	50-58	AKT serine/threonine kinase 1	Homo sapiens	81-84
11788791-15	2001	CONCLUSIONS: Collectively, our data indicate that arsenite induces activation of AKT and eNOS, via PI-3-kinase and p38 pathway, likely bypassing the activation of EGF receptor in cultured human keratinocytes.	arsenite	50-58	nitric oxide synthase 3	Homo sapiens	89-93
11788791-15	2001	CONCLUSIONS: Collectively, our data indicate that arsenite induces activation of AKT and eNOS, via PI-3-kinase and p38 pathway, likely bypassing the activation of EGF receptor in cultured human keratinocytes.	arsenite	50-58	mitogen-activated protein kinase 14	Homo sapiens	115-118
11578149-5	2001	Recently we found that low concentrations of arsenite disrupted p53 function and upregulated cyclin D1.	arsenite	45-53	transformation related protein 53, pseudogene	Mus musculus	64-67
11578149-5	2001	Recently we found that low concentrations of arsenite disrupted p53 function and upregulated cyclin D1.	arsenite	45-53	cyclin D1	Mus musculus	93-102
11461905-10	2001	These results suggest that Acr2p utilizes a phosphatase-like Cys(X)(5)Arg motif as the catalytic center to reduce arsenate to arsenite.	arsenite	126-134	Arr2p	Saccharomyces cerevisiae S288C	27-32
11848479-4	2001	Arsenite induced AP-1 transcriptional activity at the same concentration (20 microM) as was effective for inducing apoptosis.	arsenite	0-8	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	17-21
11848479-8	2001	These results indicate that aspirin and SA inhibit arsenite-induced apoptosis through the inhibition of the Erks/AP-1 pathway.	arsenite	51-59	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	113-117
11514101-0	2001	Suppression of Fas ligand expression on endothelial cells by arsenite through reactive oxygen species.	arsenite	61-69	Fas ligand	Homo sapiens	15-25
11514101-3	2001	The present study has demonstrated that arsenite not arsenate decreased the Fas ligand (FasL) expression on ECV304 cells through reactive oxygen species.	arsenite	40-48	Fas ligand	Homo sapiens	76-86
11514101-3	2001	The present study has demonstrated that arsenite not arsenate decreased the Fas ligand (FasL) expression on ECV304 cells through reactive oxygen species.	arsenite	40-48	Fas ligand	Homo sapiens	88-92
11514101-4	2001	Incubation of ECV304 cells with arsenite decreased the FasL expression and increased the intracellular peroxide levels.	arsenite	32-40	Fas ligand	Homo sapiens	55-59
11514101-6	2001	The antioxidant, N-acetyl-cysteine, blocked the suppression of FasL expression in response to arsenite.	arsenite	94-102	Fas ligand	Homo sapiens	63-67
11514101-7	2001	These data suggested that arsenite initiates endothelium dysfunction, at least partly, by suppressing the FasL expression through activating reactive oxygen species sensitive endothelial cell signaling.	arsenite	26-34	Fas ligand	Homo sapiens	106-110
11461769-7	2001	We also show that catalase, and inhibitors of calcium, nitric oxide synthase, superoxide dismutase, and myeloperoxidase, could modulate arsenite-induced DNA damage.	arsenite	136-144	myeloperoxidase	Homo sapiens	104-119
11470536-2	2001	Arsenite or antimonite allosterically activates the ArsA ATPase activity.	arsenite	0-8	arylsulfatase A	Homo sapiens	52-56
11439243-5	2001	Using these two assays, we show that DJNK activity is stimulated in cultured cells by several treatments that activate mammalian JNKs, including addition of arsenite, vanadate and ceramide derivatives.	arsenite	157-165	basket	Drosophila melanogaster	37-41
11446828-8	2001	Blocking the p38 or JNK signaling pathways using the inhibitors SB203580 or CEP-1347 protected cerebellar neurons against arsenite-induced apoptosis.	arsenite	122-130	mitogen activated protein kinase 14	Rattus norvegicus	13-16
11446828-8	2001	Blocking the p38 or JNK signaling pathways using the inhibitors SB203580 or CEP-1347 protected cerebellar neurons against arsenite-induced apoptosis.	arsenite	122-130	mitogen-activated protein kinase 8	Rattus norvegicus	20-23
11424214-0	2001	Heat shock proteins Hsp70-1 and Hsp70-3 Are necessary and sufficient to prevent arsenite-induced dysmorphology in mouse embryos.	arsenite	80-88	heat shock protein 1B	Mus musculus	20-27
11489357-1	2001	In a previous study we reported that methylation within the promoter region of p53 was altered in human lung A549 cells exposed to arsenite over a 2-week period in culture.	arsenite	131-139	tumor protein p53	Homo sapiens	79-82
11406180-0	2001	Effects of arsenite on p53, p21 and cyclin D expression in normal human fibroblasts -- a possible mechanism for arsenite"s comutagenicity.	arsenite	112-120	tumor protein p53	Homo sapiens	23-26
11406180-3	2001	To determine whether arsenite affects signaling which might alter DNA repair, this study assesses the effect of arsenite on p53-related signal transduction pathways after ionizing radiation.	arsenite	112-120	tumor protein p53	Homo sapiens	124-127
11406180-4	2001	Long-term (14 day) low dose (0.1 microM) arsenite caused a modest increase in p53 expression in WI38 normal human fibroblasts, while only toxic (50 microM) concentrations increased p53 levels after short-term (18 h) exposure.	arsenite	41-49	tumor protein p53	Homo sapiens	78-81
11406180-6	2001	Both long-term, low dose and short-term, high dose exposure to arsenite greatly suppressed the radiation-induced increase in p21 abundance.	arsenite	63-71	H3 histone pseudogene 16	Homo sapiens	125-128
11406180-7	2001	In addition, long-term, low dose (but not short-term, high dose) exposure to arsenite resulted in increased expression of cyclin D1.	arsenite	77-85	cyclin D1	Homo sapiens	122-131
11406180-8	2001	These results show that in cells treated with arsenite, p53-dependent increase in p21 expression, normally a block to cell cycle progression after DNA damage, is deficient.	arsenite	46-54	tumor protein p53	Homo sapiens	56-59
11406180-8	2001	These results show that in cells treated with arsenite, p53-dependent increase in p21 expression, normally a block to cell cycle progression after DNA damage, is deficient.	arsenite	46-54	H3 histone pseudogene 16	Homo sapiens	82-85
11406180-10	2001	We suggest that the absence of normal p53 functioning, along with increased positive growth signaling in the presence of DNA damage may result in defective DNA repair and account for the comutagenic effects of arsenite.	arsenite	210-218	tumor protein p53	Homo sapiens	38-41
11429707-0	2001	Contrasting roles of NF-kappaB and JNK in arsenite-induced p53-independent expression of GADD45alpha.	arsenite	42-50	nuclear factor kappa B subunit 1	Homo sapiens	21-30
11429707-0	2001	Contrasting roles of NF-kappaB and JNK in arsenite-induced p53-independent expression of GADD45alpha.	arsenite	42-50	mitogen-activated protein kinase 8	Homo sapiens	35-38
11429707-0	2001	Contrasting roles of NF-kappaB and JNK in arsenite-induced p53-independent expression of GADD45alpha.	arsenite	42-50	tumor protein p53	Homo sapiens	59-62
11429707-0	2001	Contrasting roles of NF-kappaB and JNK in arsenite-induced p53-independent expression of GADD45alpha.	arsenite	42-50	growth arrest and DNA damage inducible alpha	Homo sapiens	89-100
11429707-2	2001	We report here that arsenite induces GADD45alpha expression in a p53-independent fashion and that this GADD45alpha induction by arsenite is regulated by NF-kappaB and c-Jun-N-terminal kinase (JNK) oppositely.	arsenite	20-28	growth arrest and DNA damage inducible alpha	Homo sapiens	37-48
11429707-2	2001	We report here that arsenite induces GADD45alpha expression in a p53-independent fashion and that this GADD45alpha induction by arsenite is regulated by NF-kappaB and c-Jun-N-terminal kinase (JNK) oppositely.	arsenite	20-28	tumor protein p53	Homo sapiens	65-68
11429707-2	2001	We report here that arsenite induces GADD45alpha expression in a p53-independent fashion and that this GADD45alpha induction by arsenite is regulated by NF-kappaB and c-Jun-N-terminal kinase (JNK) oppositely.	arsenite	128-136	growth arrest and DNA damage inducible alpha	Homo sapiens	103-114
11429707-2	2001	We report here that arsenite induces GADD45alpha expression in a p53-independent fashion and that this GADD45alpha induction by arsenite is regulated by NF-kappaB and c-Jun-N-terminal kinase (JNK) oppositely.	arsenite	128-136	nuclear factor kappa B subunit 1	Homo sapiens	153-162
11429707-2	2001	We report here that arsenite induces GADD45alpha expression in a p53-independent fashion and that this GADD45alpha induction by arsenite is regulated by NF-kappaB and c-Jun-N-terminal kinase (JNK) oppositely.	arsenite	128-136	mitogen-activated protein kinase 8	Homo sapiens	192-195
11429707-4	2001	However, the G2/M cell cycle arrest and expression of GADD45alpha was substantially enhanced in response to arsenite in these cells.	arsenite	108-116	growth arrest and DNA damage inducible alpha	Homo sapiens	54-65
11429707-5	2001	Expression of a dominant-negative mutant of SEK1 that blocks JNK activation decreased arsenite-induced GADD45alpha expression.	arsenite	86-94	mitogen-activated protein kinase kinase 4	Homo sapiens	44-48
11429707-5	2001	Expression of a dominant-negative mutant of SEK1 that blocks JNK activation decreased arsenite-induced GADD45alpha expression.	arsenite	86-94	mitogen-activated protein kinase 8	Homo sapiens	61-64
11429707-5	2001	Expression of a dominant-negative mutant of SEK1 that blocks JNK activation decreased arsenite-induced GADD45alpha expression.	arsenite	86-94	growth arrest and DNA damage inducible alpha	Homo sapiens	103-114
11429707-6	2001	Analysis of GADD45alpha expression in both wild-type and p53-/- fibroblasts indicated that the induction of GADD45alpha by arsenite was independent of the status of p53 protein.	arsenite	123-131	growth arrest and DNA damage inducible alpha	Homo sapiens	12-23
11429707-6	2001	Analysis of GADD45alpha expression in both wild-type and p53-/- fibroblasts indicated that the induction of GADD45alpha by arsenite was independent of the status of p53 protein.	arsenite	123-131	tumor protein p53	Homo sapiens	57-60
11429707-6	2001	Analysis of GADD45alpha expression in both wild-type and p53-/- fibroblasts indicated that the induction of GADD45alpha by arsenite was independent of the status of p53 protein.	arsenite	123-131	growth arrest and DNA damage inducible alpha	Homo sapiens	108-119
11409934-5	2001	In addition, inhibition of hamster kidney or purified porcine heart pyruvate dehydrogenase (PDH) activity by MMA(III) or arsenite was determined.	arsenite	121-129	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	92-95
11409934-7	2001	To inhibit activity of purified porcine heart PDH activity by 50%, the concentrations (mean +/- SE) of MMA(III) as methylarsine oxide and arsenite were 17.6 +/- 4.1 and 106.1 +/- 19.8 microM, respectively.	arsenite	138-146	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	46-49
11424214-0	2001	Heat shock proteins Hsp70-1 and Hsp70-3 Are necessary and sufficient to prevent arsenite-induced dysmorphology in mouse embryos.	arsenite	80-88	heat shock protein 1A	Mus musculus	32-39
11424214-4	2001	Therefore, we evaluated the specific ability of stress-inducible Hsp70-1 and Hsp70-3 to prevent arsenite-induced dysmorphology in the cultured mouse embryo using gain- and loss-of-function models.	arsenite	96-104	heat shock protein 1B	Mus musculus	65-72
11424214-4	2001	Therefore, we evaluated the specific ability of stress-inducible Hsp70-1 and Hsp70-3 to prevent arsenite-induced dysmorphology in the cultured mouse embryo using gain- and loss-of-function models.	arsenite	96-104	heat shock protein 1A	Mus musculus	77-84
11312654-3	2001	Experiments with p53(+/-) and K6/ODC transgenic mice administered dimethylarsinic acid or arsenite have shown some degree of carcinogenic, cocarcinogenic, or promotional activity in skin or bladder.	arsenite	90-98	keratin 6	Mus musculus	30-36
11424214-6	2001	Suppression of hsp70-1 and hsp70-3 expression resulted in an up to six-fold increase in the incidence of arsenite-induced neural tube defects.	arsenite	105-113	heat shock protein 1B	Mus musculus	15-22
11424214-6	2001	Suppression of hsp70-1 and hsp70-3 expression resulted in an up to six-fold increase in the incidence of arsenite-induced neural tube defects.	arsenite	105-113	heat shock protein 1A	Mus musculus	27-34
11424214-7	2001	Gain of HSP function was accomplished by microinjecting a transgene with a constitutive promotor driving expression of the hsp70-1 coding region, and resulted in a decreased incidence of arsenite-induced neural tube defects.	arsenite	187-195	heat shock protein 1B	Mus musculus	123-130
11424214-8	2001	These results indicate that Hsp70-1 and Hsp70-3 are both necessary and sufficient for preventing arsenite-induced dysmorphology in early-somite staged mouse embryos.	arsenite	97-105	heat shock protein 1B	Mus musculus	28-35
11424214-8	2001	These results indicate that Hsp70-1 and Hsp70-3 are both necessary and sufficient for preventing arsenite-induced dysmorphology in early-somite staged mouse embryos.	arsenite	97-105	heat shock protein 1A	Mus musculus	40-47
11442837-0	2001	The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces cerevisiae.	arsenite	50-58	Fps1p	Saccharomyces cerevisiae S288C	21-26
11442837-2	2001	We present evidence that Fps1p mediates influx of the trivalent metalloids arsenite and antimonite in yeast.	arsenite	75-83	Fps1p	Saccharomyces cerevisiae S288C	25-30
11442837-3	2001	Deletion of FPS1 improves tolerance to arsenite and potassium antimonyl tartrate.	arsenite	39-47	Fps1p	Saccharomyces cerevisiae S288C	12-16
11442837-5	2001	Additional deletion of FPS1 in mutants defective in arsenite and antimonite detoxification partially suppresses their hypersensitivity to metalloid salts.	arsenite	52-60	Fps1p	Saccharomyces cerevisiae S288C	23-27
11442837-6	2001	Cells expressing a constitutively open form of the Fps1p channel are highly sensitive to both arsenite and antimonite.	arsenite	94-102	Fps1p	Saccharomyces cerevisiae S288C	51-56
11442837-7	2001	We also show by direct transport assays that arsenite uptake is mediated by Fps1p.	arsenite	45-53	Fps1p	Saccharomyces cerevisiae S288C	76-81
11678607-4	2001	Exposure of cells to arsenite or arsenate led to NFkappaB transactivation in mouse epidermal JB6 NFkappaB-luciferase reporter stable transfectants, C141 NFkappaB mass1.	arsenite	21-29	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	49-57
11678607-4	2001	Exposure of cells to arsenite or arsenate led to NFkappaB transactivation in mouse epidermal JB6 NFkappaB-luciferase reporter stable transfectants, C141 NFkappaB mass1.	arsenite	21-29	nuclear factor kappa B subunit 1	Homo sapiens	97-105
11678607-4	2001	Exposure of cells to arsenite or arsenate led to NFkappaB transactivation in mouse epidermal JB6 NFkappaB-luciferase reporter stable transfectants, C141 NFkappaB mass1.	arsenite	21-29	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	97-105
11353137-8	2001	HSP 32 was increased by 1.0 and 10 microM arsenite, while HSP 72 was increased by only 100 microM arsenite.	arsenite	42-50	heme oxygenase 1	Rattus norvegicus	0-6
11353137-8	2001	HSP 32 was increased by 1.0 and 10 microM arsenite, while HSP 72 was increased by only 100 microM arsenite.	arsenite	98-106	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	58-64
11259586-4	2001	In contrast, activation of stress-activated c-Jun N-terminal kinase and p38 pathways by expression of constitutively active mutants of Rac, transforming growth factor beta-activated kinase 1 (TAK1), MAPK kinase 3 (MKK3), or MKK6 or by treatment with arsenite or anisomycin did not alone markedly enhance MMP-1 promoter activity.	arsenite	250-258	mitogen-activated protein kinase 1	Homo sapiens	72-75
11357877-6	2001	Arsenite suppressed enzymatic activity within TA3 cells after 4 h exposure without affecting cell viability.	arsenite	0-8	trace amine associated receptor 9	Homo sapiens	46-49
11357877-9	2001	Morphological analysis and annexin V staining showed that arsenite-exposed TA3 cells underwent apoptosis within 18 h, and early stages of apoptosis began by 4 h. These findings suggest that apoptosis may be an important mechanism for arsenic-induced immunosuppression.	arsenite	58-66	trace amine associated receptor 9	Homo sapiens	75-78
11259586-4	2001	In contrast, activation of stress-activated c-Jun N-terminal kinase and p38 pathways by expression of constitutively active mutants of Rac, transforming growth factor beta-activated kinase 1 (TAK1), MAPK kinase 3 (MKK3), or MKK6 or by treatment with arsenite or anisomycin did not alone markedly enhance MMP-1 promoter activity.	arsenite	250-258	AKT serine/threonine kinase 1	Homo sapiens	135-138
11259586-4	2001	In contrast, activation of stress-activated c-Jun N-terminal kinase and p38 pathways by expression of constitutively active mutants of Rac, transforming growth factor beta-activated kinase 1 (TAK1), MAPK kinase 3 (MKK3), or MKK6 or by treatment with arsenite or anisomycin did not alone markedly enhance MMP-1 promoter activity.	arsenite	250-258	mitogen-activated protein kinase kinase 3	Homo sapiens	214-218
11259586-6	2001	Activation of p38 MAPK by arsenite also potently abrogated stimulation of MMP-1 gene expression by constitutively active Ras and Raf-1 and by phorbol ester.	arsenite	26-34	mitogen-activated protein kinase 1	Homo sapiens	14-17
11259586-6	2001	Activation of p38 MAPK by arsenite also potently abrogated stimulation of MMP-1 gene expression by constitutively active Ras and Raf-1 and by phorbol ester.	arsenite	26-34	matrix metallopeptidase 1	Homo sapiens	74-79
11259586-6	2001	Activation of p38 MAPK by arsenite also potently abrogated stimulation of MMP-1 gene expression by constitutively active Ras and Raf-1 and by phorbol ester.	arsenite	26-34	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	129-134
11259586-8	2001	Furthermore, arsenite prevented phorbol ester-induced phosphorylation of ERK1,2 kinase-MEK1,2, and this effect was dependent on p38-mediated activation of protein phosphatase 1 (PP1) and PP2A.	arsenite	13-21	mitogen-activated protein kinase 3	Homo sapiens	73-79
11259586-8	2001	Furthermore, arsenite prevented phorbol ester-induced phosphorylation of ERK1,2 kinase-MEK1,2, and this effect was dependent on p38-mediated activation of protein phosphatase 1 (PP1) and PP2A.	arsenite	13-21	mitogen-activated protein kinase kinase 1	Homo sapiens	87-93
11259586-8	2001	Furthermore, arsenite prevented phorbol ester-induced phosphorylation of ERK1,2 kinase-MEK1,2, and this effect was dependent on p38-mediated activation of protein phosphatase 1 (PP1) and PP2A.	arsenite	13-21	mitogen-activated protein kinase 1	Homo sapiens	128-131
11259586-8	2001	Furthermore, arsenite prevented phorbol ester-induced phosphorylation of ERK1,2 kinase-MEK1,2, and this effect was dependent on p38-mediated activation of protein phosphatase 1 (PP1) and PP2A.	arsenite	13-21	inorganic pyrophosphatase 1	Homo sapiens	155-176
11259586-8	2001	Furthermore, arsenite prevented phorbol ester-induced phosphorylation of ERK1,2 kinase-MEK1,2, and this effect was dependent on p38-mediated activation of protein phosphatase 1 (PP1) and PP2A.	arsenite	13-21	inorganic pyrophosphatase 1	Homo sapiens	178-181
11259586-8	2001	Furthermore, arsenite prevented phorbol ester-induced phosphorylation of ERK1,2 kinase-MEK1,2, and this effect was dependent on p38-mediated activation of protein phosphatase 1 (PP1) and PP2A.	arsenite	13-21	protein phosphatase 2 phosphatase activator	Homo sapiens	187-191
11162468-5	2001	The oxidative stressor cadmium, and the heavy metals cadmium, zinc, and arsenite induced mafG RNA levels within two hours, and maximally at five hours for cadmium and zinc.	arsenite	72-80	MAF bZIP transcription factor G	Homo sapiens	89-93
11159027-6	2001	In contrast, cytosolic Rac1 translocated to the membrane fractions of cells treated with arsenite or angiotensin II but not with tumor necrosis factor.	arsenite	89-97	Rac family small GTPase 1	Homo sapiens	23-27
11159027-8	2001	However, depleting Rac1 inhibited responses only to arsenite and angiotensin II.	arsenite	52-60	Rac family small GTPase 1	Homo sapiens	19-23
11333185-3	2001	Previous studies in our laboratory demonstrated that effects of low-dose arsenic (III) (arsenite) on expression of the hormone-regulated phosphoenolpyruvate carboxykinase (PEPCK) gene were strongly associated with the glucocorticoid receptor (GR)-mediated regulatory pathway.	arsenite	88-96	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	172-177
11333185-3	2001	Previous studies in our laboratory demonstrated that effects of low-dose arsenic (III) (arsenite) on expression of the hormone-regulated phosphoenolpyruvate carboxykinase (PEPCK) gene were strongly associated with the glucocorticoid receptor (GR)-mediated regulatory pathway.	arsenite	88-96	nuclear receptor subfamily 3 group C member 1	Homo sapiens	218-241
11333185-3	2001	Previous studies in our laboratory demonstrated that effects of low-dose arsenic (III) (arsenite) on expression of the hormone-regulated phosphoenolpyruvate carboxykinase (PEPCK) gene were strongly associated with the glucocorticoid receptor (GR)-mediated regulatory pathway.	arsenite	88-96	nuclear receptor subfamily 3 group C member 1	Homo sapiens	243-245
11333185-5	2001	Completely noncytotoxic arsenite treatments (0.3-3.3 microM) significantly decreased dexamethasone-induced expression of transiently transfected luciferase constructs containing either an intact hormone-responsive promoter from the mammalian PEPCK gene or two tandem glucocorticoid response elements (GRE).	arsenite	24-32	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	242-247
11333185-7	2001	These data indicate that nontoxic doses of arsenite can interact directly with GR complexes and selectively inhibit GR-mediated transcription, which is associated with altered nuclear function rather than a decrease in hormone-induced GR activation or nuclear translocation.	arsenite	43-51	nuclear receptor subfamily 3 group C member 1	Homo sapiens	79-81
11333185-7	2001	These data indicate that nontoxic doses of arsenite can interact directly with GR complexes and selectively inhibit GR-mediated transcription, which is associated with altered nuclear function rather than a decrease in hormone-induced GR activation or nuclear translocation.	arsenite	43-51	nuclear receptor subfamily 3 group C member 1	Homo sapiens	116-118
11333185-7	2001	These data indicate that nontoxic doses of arsenite can interact directly with GR complexes and selectively inhibit GR-mediated transcription, which is associated with altered nuclear function rather than a decrease in hormone-induced GR activation or nuclear translocation.	arsenite	43-51	nuclear receptor subfamily 3 group C member 1	Homo sapiens	116-118
11322385-0	2001	Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells.	arsenite	89-97	heat shock protein family A (Hsp70) member 4	Homo sapiens	106-111
11322385-8	2001	Overexpression of a dominant negative mutant of mitogen-activated protein kinase kinase kinase 1 (MEKK1-DN) prevents arsenite-induced ERK1/2 phosphorylation and HSP70 protein synthesis.	arsenite	117-125	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	48-96
11322385-8	2001	Overexpression of a dominant negative mutant of mitogen-activated protein kinase kinase kinase 1 (MEKK1-DN) prevents arsenite-induced ERK1/2 phosphorylation and HSP70 protein synthesis.	arsenite	117-125	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	98-103
11322385-8	2001	Overexpression of a dominant negative mutant of mitogen-activated protein kinase kinase kinase 1 (MEKK1-DN) prevents arsenite-induced ERK1/2 phosphorylation and HSP70 protein synthesis.	arsenite	117-125	mitogen-activated protein kinase 3	Homo sapiens	134-140
11322385-8	2001	Overexpression of a dominant negative mutant of mitogen-activated protein kinase kinase kinase 1 (MEKK1-DN) prevents arsenite-induced ERK1/2 phosphorylation and HSP70 protein synthesis.	arsenite	117-125	heat shock protein family A (Hsp70) member 4	Homo sapiens	161-166
11321952-1	2001	The feasible methods for oxidation and removal of arsenite[As(III)] from dispersed drinking water were based on the removal of arsenate[As(V)] by ferric sulfate.	arsenite	50-58	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	136-141
11299744-3	2001	Induction of AP-1 DNA binding activity and c-jun and c-fos expression was reported to be only observed in cells responding to arsenite, but not to arsenate.	arsenite	126-134	jun proto-oncogene	Mus musculus	43-48
11299744-3	2001	Induction of AP-1 DNA binding activity and c-jun and c-fos expression was reported to be only observed in cells responding to arsenite, but not to arsenate.	arsenite	126-134	FBJ osteosarcoma oncogene	Mus musculus	53-58
11527213-0	2001	Yap1 overproduction restores arsenite resistance to the ABC transporter deficient mutant ycf1 by activating ACR3 expression.	arsenite	29-37	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	0-4
11527213-0	2001	Yap1 overproduction restores arsenite resistance to the ABC transporter deficient mutant ycf1 by activating ACR3 expression.	arsenite	29-37	ATP-binding cassette glutathione S-conjugate transporter YCF1	Saccharomyces cerevisiae S288C	89-93
11527213-0	2001	Yap1 overproduction restores arsenite resistance to the ABC transporter deficient mutant ycf1 by activating ACR3 expression.	arsenite	29-37	Arr3p	Saccharomyces cerevisiae S288C	108-112
11527213-1	2001	Ycf1 and Acr3 are transporters that have been previously shown to protect Saccharomyces cerevisiae cells from the toxic effects of arsenite.	arsenite	131-139	ATP-binding cassette glutathione S-conjugate transporter YCF1	Saccharomyces cerevisiae S288C	0-4
11527213-1	2001	Ycf1 and Acr3 are transporters that have been previously shown to protect Saccharomyces cerevisiae cells from the toxic effects of arsenite.	arsenite	131-139	Arr3p	Saccharomyces cerevisiae S288C	9-13
11527213-3	2001	In this study, we show that overexpression of Yap1 complemented the arsenite hypersensitivity of the ycf1 null mutant, but only if the ACR3 gene is functional.	arsenite	68-76	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	46-50
11527213-3	2001	In this study, we show that overexpression of Yap1 complemented the arsenite hypersensitivity of the ycf1 null mutant, but only if the ACR3 gene is functional.	arsenite	68-76	ATP-binding cassette glutathione S-conjugate transporter YCF1	Saccharomyces cerevisiae S288C	101-105
11527213-4	2001	We further show that the expression of either an ACR3-lacZ promoter fusion reporter or the endogenous ACR3 gene was stimulated by the overproduction of Yap1 upon exposure to arsenite.	arsenite	174-182	Arr3p	Saccharomyces cerevisiae S288C	49-53
11527213-4	2001	We further show that the expression of either an ACR3-lacZ promoter fusion reporter or the endogenous ACR3 gene was stimulated by the overproduction of Yap1 upon exposure to arsenite.	arsenite	174-182	Arr3p	Saccharomyces cerevisiae S288C	102-106
11527213-4	2001	We further show that the expression of either an ACR3-lacZ promoter fusion reporter or the endogenous ACR3 gene was stimulated by the overproduction of Yap1 upon exposure to arsenite.	arsenite	174-182	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	152-156
11527213-5	2001	These data suggest that Yap1 confers arsenite resistance to the ycf1 null mutant by activating expression of the Yap8-dependent target gene, ACR3.	arsenite	37-45	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	24-28
11527213-5	2001	These data suggest that Yap1 confers arsenite resistance to the ycf1 null mutant by activating expression of the Yap8-dependent target gene, ACR3.	arsenite	37-45	ATP-binding cassette glutathione S-conjugate transporter YCF1	Saccharomyces cerevisiae S288C	64-68
11527213-5	2001	These data suggest that Yap1 confers arsenite resistance to the ycf1 null mutant by activating expression of the Yap8-dependent target gene, ACR3.	arsenite	37-45	Arr1p	Saccharomyces cerevisiae S288C	113-117
11527213-5	2001	These data suggest that Yap1 confers arsenite resistance to the ycf1 null mutant by activating expression of the Yap8-dependent target gene, ACR3.	arsenite	37-45	Arr3p	Saccharomyces cerevisiae S288C	141-145
11527213-6	2001	Our data also show Yap8-dependent ACR3-lacZ expression was greatly stimulated by arsenite in a dose-dependent manner in the parental strain.	arsenite	81-89	Arr1p	Saccharomyces cerevisiae S288C	19-23
11527213-6	2001	Our data also show Yap8-dependent ACR3-lacZ expression was greatly stimulated by arsenite in a dose-dependent manner in the parental strain.	arsenite	81-89	Arr3p	Saccharomyces cerevisiae S288C	34-38
11527213-7	2001	However, overproduction of Yap1 in the parental strain severely limited dose-dependent activation of the reporter by arsenite.	arsenite	117-125	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	27-31
11525238-4	2001	The presence of 1 mM dithiothreitol in the culture medium during exposure to chemicals suppressed the dissociation of Hsp27 induced by arsenite and CdCl2 but not by other chemicals.	arsenite	135-143	heat shock protein family B (small) member 1	Homo sapiens	118-123
11525245-4	2001	The expression of a C elegans homologue of AIRAP, aip-1, is also induced by exposure to arsenite, and expression of an aip-1::gfp transgene is most pronounced in hypodermal cells.	arsenite	88-96	flare	Drosophila melanogaster	50-55
11525245-5	2001	RNA-mediated interference (RNAi) of aip-1 lowers the resistance of nematodes to arsenite yet does not appear to affect viability under standard growth conditions.	arsenite	80-88	flare	Drosophila melanogaster	36-41
11525245-6	2001	These experiments suggest a role for AIRAP/AIP-1 in protecting cells from the toxic effects of arsenite.	arsenite	95-103	flare	Drosophila melanogaster	43-48
11147836-5	2000	The effect of Hsp90 can be blocked by sulfhydryl reagents including arsenite and cadmium, which indicates the involvement of the vicinal cysteines Cys589/590 in the reduction of cytochrome c.	arsenite	68-76	heat shock protein 90 alpha family class A member 1	Homo sapiens	14-19
11746514-2	2001	In the present study, we examined the effects of midazolam, an intravenous anesthetic, on the HSP27 induction stimulated by vasopressin, heat, or sodium arsenite (arsenite) in A10 cells.	arsenite	153-161	heat shock protein family B (small) member 1	Homo sapiens	94-99
11746514-4	2001	In contrast, midazolam enhanced the HSP27-accumulation induced by heat or arsenite.	arsenite	74-82	heat shock protein family B (small) member 1	Homo sapiens	36-41
11746514-7	2001	These results suggest that midazolam suppresses vasopressin-stimulated HSP27 induction in vascular smooth muscle cells, and that this inhibitory effect is exerted at a point downstream from protein kinase C. In contrast, midazolam enhanced heat- or arsenite-stimulated HSP27 induction.	arsenite	249-257	arginine vasopressin	Homo sapiens	48-59
11147836-5	2000	The effect of Hsp90 can be blocked by sulfhydryl reagents including arsenite and cadmium, which indicates the involvement of the vicinal cysteines Cys589/590 in the reduction of cytochrome c.	arsenite	68-76	cytochrome c, somatic	Homo sapiens	178-190
10967126-0	2000	Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase.	arsenite	39-47	nuclear factor kappa B subunit 1	Homo sapiens	14-24
10988289-8	2000	Here, we present evidence that endogenous PACT acts as a protein activator of PKR in response to diverse stress signals such as serum starvation, and peroxide or arsenite treatment.	arsenite	162-170	protein activator of interferon induced protein kinase EIF2AK2	Homo sapiens	42-46
10988289-8	2000	Here, we present evidence that endogenous PACT acts as a protein activator of PKR in response to diverse stress signals such as serum starvation, and peroxide or arsenite treatment.	arsenite	162-170	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	78-81
10967126-7	2000	The addition of 1,2-dithiol antidotes or replacement of Cys-179 with an alanine residue abolished dye binding to and arsenite inhibition of IKKbeta.	arsenite	117-125	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	140-147
10967126-8	2000	Overexpression of IKKbeta (C179A) protects NF-kappaB from inhibition by arsenite, indicating that despite the involvement of a large number of distinct gene products in this activation pathway, the critical target for inhibition by arsenite is on the IKK catalytic subunits.	arsenite	72-80	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	18-25
10967126-8	2000	Overexpression of IKKbeta (C179A) protects NF-kappaB from inhibition by arsenite, indicating that despite the involvement of a large number of distinct gene products in this activation pathway, the critical target for inhibition by arsenite is on the IKK catalytic subunits.	arsenite	72-80	nuclear factor kappa B subunit 1	Homo sapiens	43-52
10967126-8	2000	Overexpression of IKKbeta (C179A) protects NF-kappaB from inhibition by arsenite, indicating that despite the involvement of a large number of distinct gene products in this activation pathway, the critical target for inhibition by arsenite is on the IKK catalytic subunits.	arsenite	232-240	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	18-25
10967126-3	2000	Here, we describe the mechanism by which arsenite affects the NF-kappaB signaling pathway.	arsenite	41-49	nuclear factor kappa B subunit 1	Homo sapiens	62-71
10967126-5	2000	We found that arsenite potently inhibits NF-kappaB and IKK activation by binding to Cys-179 in the activation loop of the IKK catalytic subunits, IKKalpha/beta.	arsenite	14-22	nuclear factor kappa B subunit 1	Homo sapiens	41-50
10967126-5	2000	We found that arsenite potently inhibits NF-kappaB and IKK activation by binding to Cys-179 in the activation loop of the IKK catalytic subunits, IKKalpha/beta.	arsenite	14-22	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	146-159
11103796-0	2000	Arsenite induces p53 accumulation through an ATM-dependent pathway in human fibroblasts.	arsenite	0-8	tumor protein p53	Homo sapiens	17-20
11103796-0	2000	Arsenite induces p53 accumulation through an ATM-dependent pathway in human fibroblasts.	arsenite	0-8	ATM serine/threonine kinase	Homo sapiens	45-48
11103796-3	2000	Because p53 plays a guarding role in maintaining genome integrity and accuracy of chromosome segregation, the mechanistic effects of arsenite on p53 activation were analyzed.	arsenite	133-141	tumor protein p53	Homo sapiens	145-148
11103796-5	2000	Accompanying the appearance of DNA strand breaks was a significant accumulation of p53 in arsenite-treated HFW cells, as demonstrated by immunoblotting and immunofluorescence techniques.	arsenite	90-98	tumor protein p53	Homo sapiens	83-86
11103796-6	2000	p53 downstream proteins, such as p21 and the human homologue of murine double minute-2, were also significantly induced by arsenite treatment.	arsenite	123-131	tumor protein p53	Homo sapiens	0-3
11103796-6	2000	p53 downstream proteins, such as p21 and the human homologue of murine double minute-2, were also significantly induced by arsenite treatment.	arsenite	123-131	H3 histone pseudogene 16	Homo sapiens	33-36
11103796-8	2000	Wortmannin, an inhibitor of phosphatidylinositol 3-kinases, inhibited arsenite- or X-ray irradiation-induced p53 accumulation but did not alter UV irradiation- or N-acetyl-Leu-Leu-norleucinal-induced p53 accumulation.	arsenite	70-78	tumor protein p53	Homo sapiens	109-112
11103796-9	2000	p53 phosphorylation on serine 15 was also confirmed by immunoblotting technique in arsenite- and X-ray-treated HFW cells but was not observed in UV- or N-acetyl-Leu-Leu-norleucinal-treated HFW cells.	arsenite	83-91	tumor protein p53	Homo sapiens	0-3
11103796-10	2000	These results suggest the involvement of a phosphatidylinositol 3-kinase-related protein kinase in arsenite-induced p53 accumulation.	arsenite	99-107	tumor protein p53	Homo sapiens	116-119
11103796-13	2000	Together, these findings infer that arsenite-induced DNA strand breaks may lead to p53 phosphorylation and accumulation through an ataxia telangiectasia mutated-dependent pathway in HFW cells.	arsenite	36-44	tumor protein p53	Homo sapiens	83-86
10952989-2	2000	Exposition of Granta 519 cells to osmotic shock, oxidative stress, and arsenite induced the post-transcriptional down-regulation of cyclin D1.	arsenite	71-79	cyclin D1	Homo sapiens	132-141
11205256-7	2000	A variety of stimuli increase the expression of the mdr1 gene: lowered extracellular pH, heat shock, arsenite, cytotoxic agents, anticancer drugs, transfection with oncogenes, HIV-I, and UV-irradiation.	arsenite	101-109	ATP binding cassette subfamily B member 1	Homo sapiens	52-56
11046111-6	2000	Two markers of monocyte differentiation, Mac-1 expression and nitroblue tetrazolium reduction, are increased in arsenite-exposed, D(3)-costimulated cells.	arsenite	112-120	integrin subunit alpha M	Homo sapiens	41-46
11046111-11	2000	Arsenite-induced apoptosis was caspase-3 dependent.	arsenite	0-8	caspase 3	Homo sapiens	31-40
11042089-0	2000	Effect of arsenite on the induction of CYP1A4 and CYP1A5 in cultured chick embryo hepatocytes.	arsenite	10-18	cytochrome P450 1A4	Gallus gallus	39-45
11042089-0	2000	Effect of arsenite on the induction of CYP1A4 and CYP1A5 in cultured chick embryo hepatocytes.	arsenite	10-18	cytochrome P450 1A2	Gallus gallus	50-56
11042089-5	2000	Glutathione depletion enhanced the effect of arsenite to decrease induction of CYP1A4.	arsenite	45-53	cytochrome P450 1A4	Gallus gallus	79-85
10923011-8	2000	RESULTS: Arsenite treatment led to increases in the phosphorylation of HSP27, a redistribution of some HSP27 from a cytosolic to a particulate fraction and to the formation of larger macromolecular aggregates of HSP27.	arsenite	9-17	heat shock protein beta-1	Bos taurus	71-76
11014213-0	2000	Effects of arsenite on estrogen receptor-alpha expression and activity in MCF-7 breast cancer cells.	arsenite	11-19	estrogen receptor 1	Homo sapiens	23-46
11014213-2	2000	Treatment of cells with 1 microM arsenite resulted in a 60% decrease in the amount of ERalpha and in a parallel decrease of 40% in ERalpha messenger RNA.	arsenite	33-41	estrogen receptor 1	Homo sapiens	86-93
11014213-2	2000	Treatment of cells with 1 microM arsenite resulted in a 60% decrease in the amount of ERalpha and in a parallel decrease of 40% in ERalpha messenger RNA.	arsenite	33-41	estrogen receptor 1	Homo sapiens	131-138
11014213-3	2000	Progesterone receptor concentration increased 22-fold after arsenite treatment.	arsenite	60-68	progesterone receptor	Homo sapiens	0-21
11014213-7	2000	In transient cotransfection experiments of wild-type ERalpha and an estrogen response element-reporter construct, arsenite stimulated chloramphenicol acetyltransferase (CAT) activity.	arsenite	114-122	estrogen receptor 1	Homo sapiens	53-60
11014213-10	2000	In binding assays, arsenite blocked the binding of estradiol to ERalpha (Ki = 5 +/- 0.5 nM; n = 3), suggesting that the compound interacts with the hormone-binding domain of the receptor.	arsenite	19-27	estrogen receptor 1	Homo sapiens	64-71
11014213-13	2000	The effects of arsenite on the chimeric receptor were blocked by the antiestrogen, suggesting that arsenite activates ERalpha through an interaction with the hormone-binding domain of the receptor.	arsenite	15-23	estrogen receptor 1	Homo sapiens	118-125
11014213-13	2000	The effects of arsenite on the chimeric receptor were blocked by the antiestrogen, suggesting that arsenite activates ERalpha through an interaction with the hormone-binding domain of the receptor.	arsenite	99-107	estrogen receptor 1	Homo sapiens	118-125
11014213-14	2000	Transfection assays with ERalpha mutants identified C381, C447, H524, and N532 as interaction sites of arsenite with the hormone-binding domain.	arsenite	103-111	estrogen receptor 1	Homo sapiens	25-32
11055208-13	2000	The signal cascade triggered by arsenite-like heat stress induces the activity of the mitogen-activated protein (MAP) kinases, extracellular regulated kinase (ERK), c-jun terminal kinase (JNK), and p38.	arsenite	32-40	mitogen-activated protein kinase 8	Homo sapiens	165-186
11055208-13	2000	The signal cascade triggered by arsenite-like heat stress induces the activity of the mitogen-activated protein (MAP) kinases, extracellular regulated kinase (ERK), c-jun terminal kinase (JNK), and p38.	arsenite	32-40	mitogen-activated protein kinase 8	Homo sapiens	188-191
11055208-13	2000	The signal cascade triggered by arsenite-like heat stress induces the activity of the mitogen-activated protein (MAP) kinases, extracellular regulated kinase (ERK), c-jun terminal kinase (JNK), and p38.	arsenite	32-40	mitogen-activated protein kinase 14	Homo sapiens	198-201
11055208-14	2000	Through the JNK and p38 pathways, arsenite activates the immediate early genes c-fos, c-jun, and egr-1, usually activated by various growth factors, cytokines, differentiation signals, and DNA-damaging agents.	arsenite	34-42	mitogen-activated protein kinase 8	Homo sapiens	12-15
11055208-14	2000	Through the JNK and p38 pathways, arsenite activates the immediate early genes c-fos, c-jun, and egr-1, usually activated by various growth factors, cytokines, differentiation signals, and DNA-damaging agents.	arsenite	34-42	mitogen-activated protein kinase 14	Homo sapiens	20-23
11055208-14	2000	Through the JNK and p38 pathways, arsenite activates the immediate early genes c-fos, c-jun, and egr-1, usually activated by various growth factors, cytokines, differentiation signals, and DNA-damaging agents.	arsenite	34-42	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	79-84
11055208-14	2000	Through the JNK and p38 pathways, arsenite activates the immediate early genes c-fos, c-jun, and egr-1, usually activated by various growth factors, cytokines, differentiation signals, and DNA-damaging agents.	arsenite	34-42	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	86-91
11055208-14	2000	Through the JNK and p38 pathways, arsenite activates the immediate early genes c-fos, c-jun, and egr-1, usually activated by various growth factors, cytokines, differentiation signals, and DNA-damaging agents.	arsenite	34-42	early growth response 1	Homo sapiens	97-102
11068817-0	2000	Resistance to arsenite modulates levels of alpha-tubulin and sensitivity to paclitaxel in Leishmania donovani.	arsenite	14-22	alpha tubulin	Leishmania donovani	43-56
11068817-3	2000	In this study, alpha-tubulin expression under various stages of differentiation was measured in an in vitro generated arsenite-resistant L. donovani strain.	arsenite	118-126	alpha tubulin	Leishmania donovani	15-28
10930531-4	2000	After release from arsenite treatment, more than 80% of arsenite-arrested mitotic cells subsequently underwent apoptosis, as indicated by anachronistic nuclear envelope reformation, DNA ladder occurrence, chromatin condensation, and activation of caspases 3 and 9.	arsenite	19-27	caspase 3	Homo sapiens	247-263
10930531-4	2000	After release from arsenite treatment, more than 80% of arsenite-arrested mitotic cells subsequently underwent apoptosis, as indicated by anachronistic nuclear envelope reformation, DNA ladder occurrence, chromatin condensation, and activation of caspases 3 and 9.	arsenite	56-64	caspase 3	Homo sapiens	247-263
10964950-0	2000	Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase.	arsenite	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	62-67
10964950-0	2000	Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase.	arsenite	0-8	mitogen-activated protein kinase 14	Homo sapiens	100-103
10964950-9	2000	Expression of dominant-interfering mutants of the JNK or p38 pathways inhibited apoptosis induced by arsenite, whereas expression of constitutive active mutants for either pathway induced apoptosis.	arsenite	101-109	mitogen-activated protein kinase 8	Homo sapiens	50-53
10964950-9	2000	Expression of dominant-interfering mutants of the JNK or p38 pathways inhibited apoptosis induced by arsenite, whereas expression of constitutive active mutants for either pathway induced apoptosis.	arsenite	101-109	mitogen-activated protein kinase 14	Homo sapiens	57-60
10964950-10	2000	Moreover, the caspase inhibitor zVAD-fluoromethylketone as well as expression of bcl-2 or bcl-xL inhibited cortical neuron apoptosis induced by arsenite or by constitutive activation of JNK or p38.	arsenite	144-152	BCL2 apoptosis regulator	Homo sapiens	81-86
10964950-10	2000	Moreover, the caspase inhibitor zVAD-fluoromethylketone as well as expression of bcl-2 or bcl-xL inhibited cortical neuron apoptosis induced by arsenite or by constitutive activation of JNK or p38.	arsenite	144-152	BCL2 like 1	Homo sapiens	90-96
10964950-11	2000	These data indicate that both JNK and p38 contribute to arsenite-induced apoptosis in primary CNS neurons, and this apoptosis requires the bcl-2-caspase pathway.	arsenite	56-64	mitogen-activated protein kinase 8	Homo sapiens	30-33
10964950-11	2000	These data indicate that both JNK and p38 contribute to arsenite-induced apoptosis in primary CNS neurons, and this apoptosis requires the bcl-2-caspase pathway.	arsenite	56-64	mitogen-activated protein kinase 14	Homo sapiens	38-41
10964950-11	2000	These data indicate that both JNK and p38 contribute to arsenite-induced apoptosis in primary CNS neurons, and this apoptosis requires the bcl-2-caspase pathway.	arsenite	56-64	BCL2 apoptosis regulator	Homo sapiens	139-144
10944550-6	2000	MRP1 can even confer resistance to arsenite and MRP2 to cisplatin, again probably by transporting these compounds in complexes with GSH.	arsenite	35-43	ATP binding cassette subfamily C member 1	Homo sapiens	0-4
10816597-5	2000	The stress inducers arsenite, butyrate, and etoposide also increased pMDR1(-1202) promoter activity, but the increase was not inhibited (in the case of butyrate) or was only partially inhibited (in the case of arsenite and etoposide) by HSF1(-).	arsenite	20-28	heat shock transcription factor 1	Homo sapiens	237-241
11059771-6	2000	Lines lacking both P-gp and Mrp1 were (compared with wild-type lines) hypersensitive to an even broader array of drugs, including epipodophyllotoxins (4-7-fold), anthracyclines (6-7-fold), camptothecins (3-fold), arsenite (4-fold) and Vinca alkaloids, especially vincristine (28-fold).	arsenite	213-221	phosphoglycolate phosphatase	Mus musculus	19-23
11059771-6	2000	Lines lacking both P-gp and Mrp1 were (compared with wild-type lines) hypersensitive to an even broader array of drugs, including epipodophyllotoxins (4-7-fold), anthracyclines (6-7-fold), camptothecins (3-fold), arsenite (4-fold) and Vinca alkaloids, especially vincristine (28-fold).	arsenite	213-221	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	28-32
10923011-8	2000	RESULTS: Arsenite treatment led to increases in the phosphorylation of HSP27, a redistribution of some HSP27 from a cytosolic to a particulate fraction and to the formation of larger macromolecular aggregates of HSP27.	arsenite	9-17	heat shock protein beta-1	Bos taurus	103-108
10923011-8	2000	RESULTS: Arsenite treatment led to increases in the phosphorylation of HSP27, a redistribution of some HSP27 from a cytosolic to a particulate fraction and to the formation of larger macromolecular aggregates of HSP27.	arsenite	9-17	heat shock protein beta-1	Bos taurus	103-108
10894889-2	2000	Arsenite is also a potent inducer of heme oxygenase (HO)-1.	arsenite	0-8	heme oxygenase 1	Homo sapiens	37-58
10801893-3	2000	It reduces arsenate to arsenite, which is then extruded from cells by Acr3p.	arsenite	23-31	Arr3p	Saccharomyces cerevisiae S288C	70-75
10910055-6	2000	Gene expression studies using RNase protection assays, reverse transcription-PCR, and cDNA microarrays indicated that arsenite alters the expression of a number of genes associated with cell growth, such as c-fos, c-jun, and EGR-1, as well as cell arrest, such as GADD153 and GADD45.	arsenite	118-126	FBJ osteosarcoma oncogene	Mus musculus	207-212
10910055-6	2000	Gene expression studies using RNase protection assays, reverse transcription-PCR, and cDNA microarrays indicated that arsenite alters the expression of a number of genes associated with cell growth, such as c-fos, c-jun, and EGR-1, as well as cell arrest, such as GADD153 and GADD45.	arsenite	118-126	jun proto-oncogene	Mus musculus	214-219
10910055-6	2000	Gene expression studies using RNase protection assays, reverse transcription-PCR, and cDNA microarrays indicated that arsenite alters the expression of a number of genes associated with cell growth, such as c-fos, c-jun, and EGR-1, as well as cell arrest, such as GADD153 and GADD45.	arsenite	118-126	early growth response 1	Mus musculus	225-230
10910055-6	2000	Gene expression studies using RNase protection assays, reverse transcription-PCR, and cDNA microarrays indicated that arsenite alters the expression of a number of genes associated with cell growth, such as c-fos, c-jun, and EGR-1, as well as cell arrest, such as GADD153 and GADD45.	arsenite	118-126	DNA-damage inducible transcript 3	Mus musculus	264-271
10910055-6	2000	Gene expression studies using RNase protection assays, reverse transcription-PCR, and cDNA microarrays indicated that arsenite alters the expression of a number of genes associated with cell growth, such as c-fos, c-jun, and EGR-1, as well as cell arrest, such as GADD153 and GADD45.	arsenite	118-126	growth arrest and DNA-damage-inducible 45 alpha	Mus musculus	276-282
11005379-0	2000	Heat shock and arsenite induce expression of the nonclassical class I histocompatibility HLA-G gene in tumor cell lines.	arsenite	15-23	major histocompatibility complex, class I, G	Homo sapiens	89-94
11005379-2	2000	To explore mechanisms involved in HLA-G transcriptional regulation, we have investigated the effect of stress, including heat shock and arsenite treatment, on HLA-G expression in tumor cell lines.	arsenite	136-144	major histocompatibility complex, class I, G	Homo sapiens	159-164
10747897-2	2000	Here we demonstrate that the stress signaling agents anisomycin, arsenite, and tumor necrosis factor-alpha stimulate the specific enzyme activity of CK2 in the human cervical carcinoma HeLa cells by up to 8-fold, and this could be blocked by the p38 MAP kinase inhibitor SB203580.	arsenite	65-73	mitogen-activated protein kinase 14	Homo sapiens	246-249
10897240-8	2000	It includes an additional, inversely oriented gene (ARS), tentatively associated with arsenite resistance.	arsenite	86-94	RIEG2	Homo sapiens	52-55
10652248-2	2000	Previously, we showed that the cell death induced in day 9 mouse embryos by three teratogens, hyperthermia (HS), 4-hydroperoxycyclophosphamide (4-CP), and sodium arsenite (As), is apoptotic in nature involving the activation of caspase-3, cleavage of poly(ADP-ribose) polymerase (PARP), and DNA fragmentation.	arsenite	172-174	caspase 3	Mus musculus	228-237
11035063-0	2000	Arsenite induces apoptosis of murine T lymphocytes through membrane raft-linked signaling for activation of c-Jun amino-terminal kinase.	arsenite	0-8	jun proto-oncogene	Mus musculus	108-113
10775461-6	2000	Exposing the cells to 500 microM arsenite, prior to adding TNF-alpha, completely inhibited IkappaBalpha degradation, NF-kappaB translocation, NF-kappaB-dependent gene transcription, and transcription of the endogenous gene for IL-8.	arsenite	33-41	nuclear factor kappa B subunit 1	Homo sapiens	142-151
10775461-6	2000	Exposing the cells to 500 microM arsenite, prior to adding TNF-alpha, completely inhibited IkappaBalpha degradation, NF-kappaB translocation, NF-kappaB-dependent gene transcription, and transcription of the endogenous gene for IL-8.	arsenite	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	227-231
10775461-7	2000	In comparison with the proteasome inhibitor MG-132, which does not affect the phosphorylation and ubiquitination of IkappaBalpha, arsenite inhibited the phosphorylation of IkappaBalpha.	arsenite	130-138	NFKB inhibitor alpha	Homo sapiens	172-184
10775461-8	2000	Furthermore, arsenite directly blocked the activity of IKK, the kinase responsible for IkappaBalpha phosphorylation.	arsenite	13-21	NFKB inhibitor alpha	Homo sapiens	87-99
10775461-6	2000	Exposing the cells to 500 microM arsenite, prior to adding TNF-alpha, completely inhibited IkappaBalpha degradation, NF-kappaB translocation, NF-kappaB-dependent gene transcription, and transcription of the endogenous gene for IL-8.	arsenite	33-41	tumor necrosis factor	Homo sapiens	59-68
10775461-6	2000	Exposing the cells to 500 microM arsenite, prior to adding TNF-alpha, completely inhibited IkappaBalpha degradation, NF-kappaB translocation, NF-kappaB-dependent gene transcription, and transcription of the endogenous gene for IL-8.	arsenite	33-41	NFKB inhibitor alpha	Homo sapiens	91-103
10775461-6	2000	Exposing the cells to 500 microM arsenite, prior to adding TNF-alpha, completely inhibited IkappaBalpha degradation, NF-kappaB translocation, NF-kappaB-dependent gene transcription, and transcription of the endogenous gene for IL-8.	arsenite	33-41	nuclear factor kappa B subunit 1	Homo sapiens	117-126
10699972-1	2000	We have isolated cisplatin-resistant human liver carcinoma (7404-CP20) cells with reduced accumulation of cisplatin and other drugs (methotrexate, arsenate, and arsenite) to which these cells are cross-resistant.	arsenite	161-169	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	65-69
10733587-5	2000	We determined that expression of the mutant BRG1 or BRM proteins impaired the ability of cells to activate the endogenous stress response gene hsp70 in response to arsenite, a metabolic inhibitor, or cadmium, a heavy metal.	arsenite	164-172	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	44-48
10733587-5	2000	We determined that expression of the mutant BRG1 or BRM proteins impaired the ability of cells to activate the endogenous stress response gene hsp70 in response to arsenite, a metabolic inhibitor, or cadmium, a heavy metal.	arsenite	164-172	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Homo sapiens	52-55
10733587-5	2000	We determined that expression of the mutant BRG1 or BRM proteins impaired the ability of cells to activate the endogenous stress response gene hsp70 in response to arsenite, a metabolic inhibitor, or cadmium, a heavy metal.	arsenite	164-172	heat shock protein family A (Hsp70) member 4	Homo sapiens	143-148
10720412-7	2000	Superoxide production and DNA strand breaks in arsenite-treated cells were also suppressed by transfecting antisense oligonucleotides of p22phox, an essential component of NADH oxidase.	arsenite	47-55	cytochrome b-245 alpha chain	Homo sapiens	137-144
10720412-8	2000	Treatment with arsenite also increased the mRNA level of p22phox.	arsenite	15-23	cytochrome b-245 alpha chain	Homo sapiens	57-64
10841042-3	2000	Arsenite induced the synthesis of IL-6 after 6 h from the stimulation up to 48 h. The effect of arsenite on IL-6 synthesis was dose-dependent in the range between 10 and 500 microM.	arsenite	96-104	interleukin 6	Mus musculus	108-112
10841042-4	2000	The arsenite-induced IL-6 synthesis was enhanced by the pretreatment with indomethacin, an inhibitor of cyclooxygenase.	arsenite	4-12	interleukin 6	Mus musculus	21-25
10841042-5	2000	Nordihydroguaiaretic acid, a lipoxygenase inhibitor, significantly amplified the arsenite-induced IL-6 synthesis.	arsenite	81-89	interleukin 6	Mus musculus	98-102
10841042-6	2000	Melittin, an activator of phospholipase A2, which by itself hardly affected the levels of IL-6, markedly enhanced the arsenite-induced IL-6 synthesis.	arsenite	118-126	phospholipase A2, group IB, pancreas	Mus musculus	26-42
10841042-6	2000	Melittin, an activator of phospholipase A2, which by itself hardly affected the levels of IL-6, markedly enhanced the arsenite-induced IL-6 synthesis.	arsenite	118-126	interleukin 6	Mus musculus	135-139
10841042-7	2000	These results strongly suggest that chemical stress induces IL-6 synthesis in osteoblasts, and that the IL-6 synthesis is coupled to the arachidonic acid cascade as well as the HSP27 induction by arsenite.	arsenite	196-204	heat shock protein 1	Mus musculus	177-182
10652248-2	2000	Previously, we showed that the cell death induced in day 9 mouse embryos by three teratogens, hyperthermia (HS), 4-hydroperoxycyclophosphamide (4-CP), and sodium arsenite (As), is apoptotic in nature involving the activation of caspase-3, cleavage of poly(ADP-ribose) polymerase (PARP), and DNA fragmentation.	arsenite	172-174	poly (ADP-ribose) polymerase family, member 1	Mus musculus	251-278
10652248-2	2000	Previously, we showed that the cell death induced in day 9 mouse embryos by three teratogens, hyperthermia (HS), 4-hydroperoxycyclophosphamide (4-CP), and sodium arsenite (As), is apoptotic in nature involving the activation of caspase-3, cleavage of poly(ADP-ribose) polymerase (PARP), and DNA fragmentation.	arsenite	172-174	poly (ADP-ribose) polymerase family, member 1	Mus musculus	280-284
10681053-1	2000	Arsenate reductase (ArsC) encoded by Staphylococcus aureus arsenic-resistance plasmid pI258 reduces intracellular As(V) (arsenate) to the more toxic As(III) (arsenite).	arsenite	158-166	Arsenate reductase	Staphylococcus aureus	0-18
10681053-1	2000	Arsenate reductase (ArsC) encoded by Staphylococcus aureus arsenic-resistance plasmid pI258 reduces intracellular As(V) (arsenate) to the more toxic As(III) (arsenite).	arsenite	158-166	Arsenate reductase	Staphylococcus aureus	20-24
10961952-2	2000	This transport ATPase confers resistance to arsenite and antimonite by their extrusion from the cells.	arsenite	44-52	ATPase	Escherichia coli	15-21
10983896-0	2000	Activation of PKC is required for arsenite-induced signal transduction.	arsenite	34-42	protein kinase C alpha	Homo sapiens	14-17
10983896-3	2000	In this study, we found that arsenite induced translocation of PKCepsilon, PKCdelta, and PKCalpha from cytosol to membranes.	arsenite	29-37	protein kinase C epsilon	Homo sapiens	63-73
10983896-3	2000	In this study, we found that arsenite induced translocation of PKCepsilon, PKCdelta, and PKCalpha from cytosol to membranes.	arsenite	29-37	protein kinase C delta	Homo sapiens	75-83
10983896-3	2000	In this study, we found that arsenite induced translocation of PKCepsilon, PKCdelta, and PKCalpha from cytosol to membranes.	arsenite	29-37	protein kinase C alpha	Homo sapiens	89-97
10983896-4	2000	Rottlerin, a selective inhibitor for PKCdelta, and safingol, a specific inhibitor for PKCalpha, both markedly inhibited arsenite-induced AP-1 activity.	arsenite	120-128	protein kinase C delta	Homo sapiens	37-45
10983896-4	2000	Rottlerin, a selective inhibitor for PKCdelta, and safingol, a specific inhibitor for PKCalpha, both markedly inhibited arsenite-induced AP-1 activity.	arsenite	120-128	protein kinase C alpha	Homo sapiens	86-94
10983896-6	2000	Arsenite-induced phosphorylation of Erks was inhibited by rottlerin, while safingol inhibited arsenite-induced phosphorylation of JNKs and p38 kinases.	arsenite	94-102	mitogen-activated protein kinase 14	Homo sapiens	139-142
10983896-7	2000	Dominant negative mutant transfectant of PKCepsilon markedly blocked arsenite-induced AP-1 activity and the phosphorylation of Erks, JNKs, and p38 kinases.	arsenite	69-77	protein kinase C epsilon	Homo sapiens	41-51
10983896-8	2000	These data demonstrate that PKCdelta, PKCepsilon, and PKCalpha mediate arsenite-induced AP-1 activation in JB6 cells through different MAP kinase (Erks, JNKs, and p38 kinases) pathways.	arsenite	71-79	protein kinase C delta	Homo sapiens	28-36
10983896-8	2000	These data demonstrate that PKCdelta, PKCepsilon, and PKCalpha mediate arsenite-induced AP-1 activation in JB6 cells through different MAP kinase (Erks, JNKs, and p38 kinases) pathways.	arsenite	71-79	protein kinase C epsilon	Homo sapiens	38-48
10983896-8	2000	These data demonstrate that PKCdelta, PKCepsilon, and PKCalpha mediate arsenite-induced AP-1 activation in JB6 cells through different MAP kinase (Erks, JNKs, and p38 kinases) pathways.	arsenite	71-79	protein kinase C alpha	Homo sapiens	54-62
10983896-8	2000	These data demonstrate that PKCdelta, PKCepsilon, and PKCalpha mediate arsenite-induced AP-1 activation in JB6 cells through different MAP kinase (Erks, JNKs, and p38 kinases) pathways.	arsenite	71-79	mitogen-activated protein kinase 14	Homo sapiens	163-166
10593884-1	1999	In Escherichia coli ArsC catalyzes the reduction of arsenate to arsenite using GSH with glutaredoxin as electron donors.	arsenite	64-72	steroid sulfatase	Homo sapiens	20-24
10606519-1	1999	Arsenate reductase (ArsC) encoded by Staphylococcus aureus arsenic-resistance plasmid pI258 reduces intracellular As(V) (arsenate) to the more toxic As(III) (arsenite), which is subsequently extruded from the cell.	arsenite	158-166	Arsenate reductase	Staphylococcus aureus	0-18
10606519-1	1999	Arsenate reductase (ArsC) encoded by Staphylococcus aureus arsenic-resistance plasmid pI258 reduces intracellular As(V) (arsenate) to the more toxic As(III) (arsenite), which is subsequently extruded from the cell.	arsenite	158-166	Arsenate reductase	Staphylococcus aureus	20-24
10606519-9	1999	From the peptide-mass profiles, cysteines 82 and 89 were identified as the redox couple of ArsC necessary to reduce arsenate to arsenite.	arsenite	128-136	Arsenate reductase	Staphylococcus aureus	91-95
10585871-8	1999	Glox I was selectively inactivated by NO; compounds that induce oxidative stress (H(2)O(2), paraquat and arsenite) failed to inhibit this enzyme.	arsenite	105-113	glyoxalase I	Homo sapiens	0-6
10618720-1	1999	Arsenate and arsenite activate c-Jun N-terminal kinase (JNK), however, the mechanism by which this occurs is not known.	arsenite	13-21	mitogen-activated protein kinase 8	Homo sapiens	31-54
10618720-1	1999	Arsenate and arsenite activate c-Jun N-terminal kinase (JNK), however, the mechanism by which this occurs is not known.	arsenite	13-21	mitogen-activated protein kinase 8	Homo sapiens	56-59
10618720-2	1999	By expressing inhibitory mutant small GTP-binding proteins, p21-activated kinase (PAK) and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinases (MEKKs), we have identified specific proteins that are involved in arsenate- and arsenite-mediated activation of JNK.	arsenite	258-266	mitogen-activated protein kinase 8	Homo sapiens	290-293
10618720-4	1999	Both arsenate and arsenite activation of JNK requires Rac and Rho.	arsenite	18-26	mitogen-activated protein kinase 8	Homo sapiens	41-44
10618720-6	1999	Arsenite stimulation of JNK requires PAK, whereas arsenate-mediated activation of JNK was unaffected by inhibitory mutant PAK.	arsenite	0-8	mitogen-activated protein kinase 8	Homo sapiens	24-27
10618720-8	1999	In contrast, arsenite-mediated JNK activation requires MEKK2, MEKK3 and MEKK4.	arsenite	13-21	mitogen-activated protein kinase 8	Homo sapiens	31-34
10618720-8	1999	In contrast, arsenite-mediated JNK activation requires MEKK2, MEKK3 and MEKK4.	arsenite	13-21	mitogen-activated protein kinase kinase kinase 2	Homo sapiens	55-60
10618720-8	1999	In contrast, arsenite-mediated JNK activation requires MEKK2, MEKK3 and MEKK4.	arsenite	13-21	mitogen-activated protein kinase kinase kinase 3	Homo sapiens	62-67
10618720-8	1999	In contrast, arsenite-mediated JNK activation requires MEKK2, MEKK3 and MEKK4.	arsenite	13-21	mitogen-activated protein kinase kinase kinase 4	Homo sapiens	72-77
10618720-9	1999	These results better define the mechanisms by which arsenate and arsenite activate JNK and demonstrate differences in the regulation of signal transduction pathways by these inorganic arsenic species.	arsenite	65-73	mitogen-activated protein kinase 8	Homo sapiens	83-86
10477262-3	1999	We now show that cellular stresses such as arsenite, anisomycin and heat shock also result in increased phosphorylation of eIF4E, eIF4F complex formation and the association of PABP with eIF4G, in conditions under which the rate of protein synthesis is severely inhibited.	arsenite	43-51	eukaryotic translation initiation factor 4E L homeolog	Xenopus laevis	123-128
10567216-5	1999	Arsenite caused a steady increase of MAPKAP-K2 activity up to 15 min.	arsenite	0-8	MAPK activated protein kinase 2	Homo sapiens	37-46
10604879-8	1999	When the K(m) values of rabbit liver arsenite methyltransferase (5.5 x 10(-)(6) M) and MMA(III) methyltransferase (9.2 x 10(-)(6)) were compared to that of MMA(V) reductase (2.16 x 10(-)(3) M), it can be concluded that MMA(V) reductase was the rate-limiting enzyme of inorganic arsenite biotransformation.	arsenite	37-45	glutathione S-transferase omega 2	Homo sapiens	156-172
10604879-8	1999	When the K(m) values of rabbit liver arsenite methyltransferase (5.5 x 10(-)(6) M) and MMA(III) methyltransferase (9.2 x 10(-)(6)) were compared to that of MMA(V) reductase (2.16 x 10(-)(3) M), it can be concluded that MMA(V) reductase was the rate-limiting enzyme of inorganic arsenite biotransformation.	arsenite	37-45	glutathione S-transferase omega 2	Homo sapiens	219-235
10841042-1	2000	In a previous study, we have demonstrated that sodium arsenite (arsenite) as chemical stress stimulates heat shock protein 27 (HSP27) induction and arachidonic acid release in osteoblast-like MC3T3-E1 cells, and that the response of HSP27 induction is coupled with metabolic activity of the arachidonic acid cascade.	arsenite	54-62	heat shock protein 1	Mus musculus	104-125
10841042-1	2000	In a previous study, we have demonstrated that sodium arsenite (arsenite) as chemical stress stimulates heat shock protein 27 (HSP27) induction and arachidonic acid release in osteoblast-like MC3T3-E1 cells, and that the response of HSP27 induction is coupled with metabolic activity of the arachidonic acid cascade.	arsenite	54-62	heat shock protein 1	Mus musculus	127-132
10841042-1	2000	In a previous study, we have demonstrated that sodium arsenite (arsenite) as chemical stress stimulates heat shock protein 27 (HSP27) induction and arachidonic acid release in osteoblast-like MC3T3-E1 cells, and that the response of HSP27 induction is coupled with metabolic activity of the arachidonic acid cascade.	arsenite	54-62	heat shock protein 1	Mus musculus	233-238
10841042-2	2000	In the present study, we examined the effect of exposure to arsenite on the synthesis of interleukin-6 (IL-6) in these cells.	arsenite	60-68	interleukin 6	Mus musculus	89-102
10841042-2	2000	In the present study, we examined the effect of exposure to arsenite on the synthesis of interleukin-6 (IL-6) in these cells.	arsenite	60-68	interleukin 6	Mus musculus	104-108
10841042-3	2000	Arsenite induced the synthesis of IL-6 after 6 h from the stimulation up to 48 h. The effect of arsenite on IL-6 synthesis was dose-dependent in the range between 10 and 500 microM.	arsenite	0-8	interleukin 6	Mus musculus	34-38
10841042-3	2000	Arsenite induced the synthesis of IL-6 after 6 h from the stimulation up to 48 h. The effect of arsenite on IL-6 synthesis was dose-dependent in the range between 10 and 500 microM.	arsenite	0-8	interleukin 6	Mus musculus	108-112
10841042-3	2000	Arsenite induced the synthesis of IL-6 after 6 h from the stimulation up to 48 h. The effect of arsenite on IL-6 synthesis was dose-dependent in the range between 10 and 500 microM.	arsenite	96-104	interleukin 6	Mus musculus	34-38
10564512-0	1999	Elevated levels of polyamines and trypanothione resulting from overexpression of the ornithine decarboxylase gene in arsenite-resistant Leishmania.	arsenite	117-125	ornithine decarboxylase 1	Homo sapiens	85-108
10564512-7	1999	Stable transfection of the ODC gene increases the level of trypanothione, which can contribute to arsenite resistance.	arsenite	98-106	ornithine decarboxylase 1	Homo sapiens	27-30
10521501-0	1999	Arsenite exposure of cultured airway epithelial cells activates kappaB-dependent interleukin-8 gene expression in the absence of nuclear factor-kappaB nuclear translocation.	arsenite	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	81-94
10491313-4	1999	Arsenite reduced p53 levels while concomitantly increasing the p53 regulatory protein mdm2 levels in a dose- and time-dependent manner.	arsenite	0-8	tumor protein p53	Homo sapiens	17-20
10491313-4	1999	Arsenite reduced p53 levels while concomitantly increasing the p53 regulatory protein mdm2 levels in a dose- and time-dependent manner.	arsenite	0-8	tumor protein p53	Homo sapiens	63-66
10491313-4	1999	Arsenite reduced p53 levels while concomitantly increasing the p53 regulatory protein mdm2 levels in a dose- and time-dependent manner.	arsenite	0-8	MDM2 proto-oncogene	Homo sapiens	86-90
10477262-3	1999	We now show that cellular stresses such as arsenite, anisomycin and heat shock also result in increased phosphorylation of eIF4E, eIF4F complex formation and the association of PABP with eIF4G, in conditions under which the rate of protein synthesis is severely inhibited.	arsenite	43-51	eukaryotic translation initiation factor 4A2 L homeolog	Xenopus laevis	130-135
10477262-3	1999	We now show that cellular stresses such as arsenite, anisomycin and heat shock also result in increased phosphorylation of eIF4E, eIF4F complex formation and the association of PABP with eIF4G, in conditions under which the rate of protein synthesis is severely inhibited.	arsenite	43-51	poly(A) binding protein, cytoplasmic 1 S homeolog	Xenopus laevis	177-181
10477262-3	1999	We now show that cellular stresses such as arsenite, anisomycin and heat shock also result in increased phosphorylation of eIF4E, eIF4F complex formation and the association of PABP with eIF4G, in conditions under which the rate of protein synthesis is severely inhibited.	arsenite	43-51	eukaryotic translation initiation factor 4 gamma, 1 S homeolog	Xenopus laevis	187-192
10473555-5	1999	Under conditions of Nrf2M overexpression, HO-1 mRNA accumulation in response to heme, cadmium, zinc, arsenite, and tert-butylhydroquinone was inhibited by 85-95%.	arsenite	101-109	heme oxygenase 1	Mus musculus	42-46
10519165-6	1999	Using deletion-reporter gene constructs, we have mapped sites that mediate the arsenite-dependent induction of HO-1, and we have shown that components of the extracellular signal-regulated kinase (ERK) and p38 (a homologue of the yeast HOG1 kinase), but not c-jun N-terminal kinase (JNK), mitogen-activated protein (MAP) kinase pathways are involved in arsenite-dependent upregulation.	arsenite	79-87	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	236-240
10428782-7	1999	Sorbitol, H(2)O(2), and arsenite each blocked IkappaBalpha phosphorylation induced by TNF, and SB203580 reversed the inhibitory effects of sorbitol and H(2)O(2), but not arsenite.	arsenite	24-32	NFKB inhibitor alpha	Homo sapiens	46-58
10428782-7	1999	Sorbitol, H(2)O(2), and arsenite each blocked IkappaBalpha phosphorylation induced by TNF, and SB203580 reversed the inhibitory effects of sorbitol and H(2)O(2), but not arsenite.	arsenite	24-32	tumor necrosis factor	Homo sapiens	86-89
10428782-8	1999	In addition, sorbitol and H(2)O(2) blocked TNF-induced but not interleukin-1-induced IkappaBalpha phosphorylation, whereas arsenite inhibited IkappaBalpha phosphorylation induced by TNF and interleukin-1.	arsenite	123-131	NFKB inhibitor alpha	Homo sapiens	142-154
10354596-2	1999	Yeasts extrude arsenite using Acr3p, a plasma membrane carrier protein, or sequester it in vacuoles as the glutathione conjugate using Ycf1p, an ABC transporter.	arsenite	15-23	Arr3p	Saccharomyces cerevisiae S288C	30-35
10366441-5	1999	In contrast, Bcl-2 expression induced by gene transfer prevents all hallmarks of arsenite-induced cell death, including the Delta Psim collapse.	arsenite	81-89	BCL2 apoptosis regulator	Homo sapiens	13-18
10366441-10	1999	Arsenite also opens the purified, reconstituted PT pore in vitro in a cyclosporin A- and Bcl-2-inhibitible fashion.	arsenite	0-8	BCL2 apoptosis regulator	Homo sapiens	89-94
10336432-7	1999	However, IL-3 deprivation as well as diverse cell stress treatments including arsenite, thapsigargin, and H2O2, which are known to inhibit protein synthesis, induce the rapid phosphorylation of RAX followed by RAX-PKR association and activation of PKR.	arsenite	78-86	retina and anterior neural fold homeobox	Homo sapiens	194-197
10336432-7	1999	However, IL-3 deprivation as well as diverse cell stress treatments including arsenite, thapsigargin, and H2O2, which are known to inhibit protein synthesis, induce the rapid phosphorylation of RAX followed by RAX-PKR association and activation of PKR.	arsenite	78-86	retina and anterior neural fold homeobox	Homo sapiens	210-213
10336432-7	1999	However, IL-3 deprivation as well as diverse cell stress treatments including arsenite, thapsigargin, and H2O2, which are known to inhibit protein synthesis, induce the rapid phosphorylation of RAX followed by RAX-PKR association and activation of PKR.	arsenite	78-86	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	214-217
10336432-7	1999	However, IL-3 deprivation as well as diverse cell stress treatments including arsenite, thapsigargin, and H2O2, which are known to inhibit protein synthesis, induce the rapid phosphorylation of RAX followed by RAX-PKR association and activation of PKR.	arsenite	78-86	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	248-251
10329651-0	1999	Requirement of Erk, but not JNK, for arsenite-induced cell transformation.	arsenite	37-45	mitogen-activated protein kinase 1	Homo sapiens	15-18
10329651-4	1999	Interestingly, arsenite induces Erk phosphorylation and increased Erk activity at doses ranging from 0.8 to 200 microM, while higher doses (more than 50 microM) are required for activation of JNK.	arsenite	15-23	mitogen-activated protein kinase 1	Homo sapiens	32-35
10329651-4	1999	Interestingly, arsenite induces Erk phosphorylation and increased Erk activity at doses ranging from 0.8 to 200 microM, while higher doses (more than 50 microM) are required for activation of JNK.	arsenite	15-23	mitogen-activated protein kinase 1	Homo sapiens	66-69
10329651-4	1999	Interestingly, arsenite induces Erk phosphorylation and increased Erk activity at doses ranging from 0.8 to 200 microM, while higher doses (more than 50 microM) are required for activation of JNK.	arsenite	15-23	mitogen-activated protein kinase 8	Homo sapiens	192-195
10329651-5	1999	Arsenite-induced Erk activation was markedly inhibited by introduction of dominant negative Erk2 into cells, while expression of dominant negative Erk2 did not show inhibition of JNK and MEK1/2.	arsenite	0-8	mitogen-activated protein kinase 1	Homo sapiens	17-20
10329651-5	1999	Arsenite-induced Erk activation was markedly inhibited by introduction of dominant negative Erk2 into cells, while expression of dominant negative Erk2 did not show inhibition of JNK and MEK1/2.	arsenite	0-8	mitogen-activated protein kinase 1	Homo sapiens	92-96
10329651-6	1999	Furthermore, arsenite-induced cell transformation was blocked in cells expressing the dominant negative Erk2.	arsenite	13-21	mitogen-activated protein kinase 1	Homo sapiens	104-108
10329651-7	1999	In contrast, overexpression of dominant negative JNK1 was shown to increase cell transformation even though it inhibits arsenite-induced JNK activation.	arsenite	120-128	mitogen-activated protein kinase 8	Homo sapiens	49-53
10329651-7	1999	In contrast, overexpression of dominant negative JNK1 was shown to increase cell transformation even though it inhibits arsenite-induced JNK activation.	arsenite	120-128	mitogen-activated protein kinase 8	Homo sapiens	49-52
10329651-8	1999	Our results not only show that arsenite induces Erk activation, but also for the first time demonstrates that activation of Erk, but not JNK, by arsenite is required for its effects on cell transformation.	arsenite	31-39	mitogen-activated protein kinase 1	Homo sapiens	48-51
10329651-8	1999	Our results not only show that arsenite induces Erk activation, but also for the first time demonstrates that activation of Erk, but not JNK, by arsenite is required for its effects on cell transformation.	arsenite	31-39	mitogen-activated protein kinase 1	Homo sapiens	124-127
10329651-8	1999	Our results not only show that arsenite induces Erk activation, but also for the first time demonstrates that activation of Erk, but not JNK, by arsenite is required for its effects on cell transformation.	arsenite	145-153	mitogen-activated protein kinase 1	Homo sapiens	124-127
10318792-1	1999	The ATPase activity of ArsA, the catalytic subunit of the plasmid-encoded, ATP-dependent extrusion pump for arsenicals and antimonials in Escherichia coli, is allosterically activated by arsenite or antimonite.	arsenite	187-195	arylsulfatase A	Homo sapiens	23-27
10318869-3	1999	We show that treatment of cells with anisomycin, arsenite, sodium fluoride, or tetrafluoroaluminate induces phosphorylation of SRF at Ser-103 in both HeLa and NIH3T3 cells.	arsenite	49-57	serum response factor	Homo sapiens	127-130
10318869-6	1999	Comparison of wild type murine fibroblasts with those derived from MK2-deficient mice (Mk(-/-)) reveals MK2 as the major SRF kinase induced by arsenite.	arsenite	143-151	serum response factor	Mus musculus	121-124
10329507-0	1999	Effect of arsenite on induction of CYP1A, CYP2B, and CYP3A in primary cultures of rat hepatocytes.	arsenite	10-18	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	53-58
10329507-5	1999	With 3-methylcholanthrene as inducer, 5 microM arsenite caused a 55% decrease in CYP1A1 immunoreactive protein and enzyme activity, but only a 25% decrease in CYP1A1 mRNA.	arsenite	47-55	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	81-87
10329507-5	1999	With 3-methylcholanthrene as inducer, 5 microM arsenite caused a 55% decrease in CYP1A1 immunoreactive protein and enzyme activity, but only a 25% decrease in CYP1A1 mRNA.	arsenite	47-55	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	159-165
10329507-6	1999	With phenobarbital (PB) as the inducer, 2.5 microM arsenite decreased CYP2B enzyme activity and immunoreactive protein 50%, with only a 25% decrease in CYP2B1 mRNA.	arsenite	51-59	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	152-158
10329507-7	1999	5 microM Arsenite decreased CYP2B enzyme activity and immunoreactive protein 80%, but decreased CYP2B1 mRNA only 50%, while CYP3A protein was decreased greater than 75% with no decrease in CYP3A23 mRNA.	arsenite	9-17	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	96-102
10220408-2	1999	Acr3p is a plasma membrane transporter that confers resistance to arsenite, presumably by arsenite extrusion from the cells.	arsenite	66-74	Arr3p	Saccharomyces cerevisiae S288C	0-5
10220408-2	1999	Acr3p is a plasma membrane transporter that confers resistance to arsenite, presumably by arsenite extrusion from the cells.	arsenite	90-98	Arr3p	Saccharomyces cerevisiae S288C	0-5
10220408-3	1999	Ycf1p, a member of the ABC transporter superfamily, catalyzes the ATP-driven uptake of As(III) into the vacuole, also producing resistance to arsenite.	arsenite	142-150	ATP-binding cassette glutathione S-conjugate transporter YCF1	Saccharomyces cerevisiae S288C	0-5
10220408-5	1999	Disruption of either the ACR3 or YCF1 gene results in sensitivity to arsenite and disruption of both genes produces additive hypersensitivity.	arsenite	69-77	Arr3p	Saccharomyces cerevisiae S288C	25-29
10220408-5	1999	Disruption of either the ACR3 or YCF1 gene results in sensitivity to arsenite and disruption of both genes produces additive hypersensitivity.	arsenite	69-77	ATP-binding cassette glutathione S-conjugate transporter YCF1	Saccharomyces cerevisiae S288C	33-37
10220408-6	1999	Thus, Acr3p and Ycf1p represent separate pathways for the detoxification of arsenite in yeast.	arsenite	76-84	Arr3p	Saccharomyces cerevisiae S288C	6-11
10220408-6	1999	Thus, Acr3p and Ycf1p represent separate pathways for the detoxification of arsenite in yeast.	arsenite	76-84	ATP-binding cassette glutathione S-conjugate transporter YCF1	Saccharomyces cerevisiae S288C	16-21
10085237-2	1999	We recently demonstrated that arsenite treatment of rat pheochromocytoma PC12 cells results in the biphasic induction of Gadd153 mRNA expression, controlled in part through binding of C/EBPbeta and two uncharacterized protein complexes to the C/EBP-ATF (activating transcription factor) composite site in the Gadd153 promoter.	arsenite	30-38	DNA-damage inducible transcript 3	Rattus norvegicus	121-128
10085237-2	1999	We recently demonstrated that arsenite treatment of rat pheochromocytoma PC12 cells results in the biphasic induction of Gadd153 mRNA expression, controlled in part through binding of C/EBPbeta and two uncharacterized protein complexes to the C/EBP-ATF (activating transcription factor) composite site in the Gadd153 promoter.	arsenite	30-38	CCAAT/enhancer binding protein beta	Rattus norvegicus	184-193
10085237-2	1999	We recently demonstrated that arsenite treatment of rat pheochromocytoma PC12 cells results in the biphasic induction of Gadd153 mRNA expression, controlled in part through binding of C/EBPbeta and two uncharacterized protein complexes to the C/EBP-ATF (activating transcription factor) composite site in the Gadd153 promoter.	arsenite	30-38	CCAAT/enhancer binding protein gamma	Rattus norvegicus	184-189
10085237-2	1999	We recently demonstrated that arsenite treatment of rat pheochromocytoma PC12 cells results in the biphasic induction of Gadd153 mRNA expression, controlled in part through binding of C/EBPbeta and two uncharacterized protein complexes to the C/EBP-ATF (activating transcription factor) composite site in the Gadd153 promoter.	arsenite	30-38	glial cell derived neurotrophic factor	Rattus norvegicus	249-252
10085237-2	1999	We recently demonstrated that arsenite treatment of rat pheochromocytoma PC12 cells results in the biphasic induction of Gadd153 mRNA expression, controlled in part through binding of C/EBPbeta and two uncharacterized protein complexes to the C/EBP-ATF (activating transcription factor) composite site in the Gadd153 promoter.	arsenite	30-38	glial cell derived neurotrophic factor	Rattus norvegicus	254-285
10085237-2	1999	We recently demonstrated that arsenite treatment of rat pheochromocytoma PC12 cells results in the biphasic induction of Gadd153 mRNA expression, controlled in part through binding of C/EBPbeta and two uncharacterized protein complexes to the C/EBP-ATF (activating transcription factor) composite site in the Gadd153 promoter.	arsenite	30-38	DNA-damage inducible transcript 3	Rattus norvegicus	309-316
10085237-3	1999	In this report, we identified components of these additional complexes as two ATF/CREB (cAMP-responsive-element-binding protein) transcription factors having differential binding activities dependent upon the time of arsenite exposure.	arsenite	217-225	glial cell derived neurotrophic factor	Rattus norvegicus	78-81
10085237-3	1999	In this report, we identified components of these additional complexes as two ATF/CREB (cAMP-responsive-element-binding protein) transcription factors having differential binding activities dependent upon the time of arsenite exposure.	arsenite	217-225	cAMP responsive element binding protein 1	Rattus norvegicus	82-86
10085237-4	1999	During arsenite treatment of PC12 cells, we observed enhanced binding of ATF4 to the C/EBP-ATF site at 2 h as Gadd153 mRNA levels increased, and enhanced binding of ATF3 complexes at 6 h as Gadd153 expression declined.	arsenite	7-15	activating transcription factor 4	Rattus norvegicus	73-77
10085237-4	1999	During arsenite treatment of PC12 cells, we observed enhanced binding of ATF4 to the C/EBP-ATF site at 2 h as Gadd153 mRNA levels increased, and enhanced binding of ATF3 complexes at 6 h as Gadd153 expression declined.	arsenite	7-15	CCAAT/enhancer binding protein gamma	Rattus norvegicus	85-90
10085237-4	1999	During arsenite treatment of PC12 cells, we observed enhanced binding of ATF4 to the C/EBP-ATF site at 2 h as Gadd153 mRNA levels increased, and enhanced binding of ATF3 complexes at 6 h as Gadd153 expression declined.	arsenite	7-15	glial cell derived neurotrophic factor	Rattus norvegicus	73-76
10085237-4	1999	During arsenite treatment of PC12 cells, we observed enhanced binding of ATF4 to the C/EBP-ATF site at 2 h as Gadd153 mRNA levels increased, and enhanced binding of ATF3 complexes at 6 h as Gadd153 expression declined.	arsenite	7-15	DNA-damage inducible transcript 3	Rattus norvegicus	110-117
10085237-4	1999	During arsenite treatment of PC12 cells, we observed enhanced binding of ATF4 to the C/EBP-ATF site at 2 h as Gadd153 mRNA levels increased, and enhanced binding of ATF3 complexes at 6 h as Gadd153 expression declined.	arsenite	7-15	activating transcription factor 3	Rattus norvegicus	165-169
10085237-4	1999	During arsenite treatment of PC12 cells, we observed enhanced binding of ATF4 to the C/EBP-ATF site at 2 h as Gadd153 mRNA levels increased, and enhanced binding of ATF3 complexes at 6 h as Gadd153 expression declined.	arsenite	7-15	DNA-damage inducible transcript 3	Rattus norvegicus	190-197
10085237-6	1999	ATF3 also repressed ATF4-mediated transactivation and arsenite-induced activation of the Gadd153 promoter.	arsenite	54-62	activating transcription factor 3	Rattus norvegicus	0-4
10085237-6	1999	ATF3 also repressed ATF4-mediated transactivation and arsenite-induced activation of the Gadd153 promoter.	arsenite	54-62	DNA-damage inducible transcript 3	Rattus norvegicus	89-96
10220854-9	1999	Our results suggest that Menkes protein is a potential target of arsenite.	arsenite	65-73	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	25-39
10082520-5	1999	Conversely, exposure of cells to heat shock and other protein-damaging conditions, including ethanol, arsenite, and oxidative stress, strongly reduced the rate of JNK dephosphorylation.	arsenite	102-110	mitogen-activated protein kinase 8	Homo sapiens	163-166
10069470-0	1999	Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis.	arsenite	23-31	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	85-88
10069470-9	1999	These results suggest that the tumor suppressor fau gene product or some other aspect of the ubiquitin system may be a target for arsenic toxicity and that disruption of the ubiquitin system may contribute to the genotoxicity and carcinogenicity of arsenite.	arsenite	249-257	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	48-51
9920779-0	1999	c-fos induction by heat, arsenite, and cadmium is mediated by a heat shock element in its promoter.	arsenite	25-33	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
9867869-10	1999	The cytoplasmic stressor, arsenite, which inhibits translational initiation through eIF-2 phosphorylation without affecting the ER, also produced ADP-ribosylation of GRP78.	arsenite	26-34	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	166-171
9851830-7	1998	Peroxynitrite-inactivated GAPDH was resistant to arsenite reduction and only 15% recovered by 20 mM dithiothreitol, suggesting that GAPDH-SH has been mainly oxidized to sulfinic or sulfonic acid, with a minor proportion yielding a disulfide.	arsenite	49-57	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	26-31
9920779-3	1999	In this report, we revealed that the human and rodent c-fos promoters do contain HSEs which are highly responsive to heat, arsenite, and cadmium.	arsenite	123-131	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	54-59
9766529-0	1998	Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis.	arsenite	67-75	caspase 3	Homo sapiens	43-52
9766529-7	1998	Activation of CPP32 activity, PARP (a DNA repair enzyme) degradation, and release of cytochrome c from mitochondria to the cytosol are involved in arsenite-induced apoptosis, and Bcl-2 antagonize arsenite-induced apoptosis by a mechanism that interferes in the activity of CPP32.	arsenite	147-155	caspase 3	Homo sapiens	14-19
9766529-7	1998	Activation of CPP32 activity, PARP (a DNA repair enzyme) degradation, and release of cytochrome c from mitochondria to the cytosol are involved in arsenite-induced apoptosis, and Bcl-2 antagonize arsenite-induced apoptosis by a mechanism that interferes in the activity of CPP32.	arsenite	147-155	collagen type XI alpha 2 chain	Homo sapiens	30-34
9766529-7	1998	Activation of CPP32 activity, PARP (a DNA repair enzyme) degradation, and release of cytochrome c from mitochondria to the cytosol are involved in arsenite-induced apoptosis, and Bcl-2 antagonize arsenite-induced apoptosis by a mechanism that interferes in the activity of CPP32.	arsenite	147-155	cytochrome c, somatic	Homo sapiens	85-97
9766529-7	1998	Activation of CPP32 activity, PARP (a DNA repair enzyme) degradation, and release of cytochrome c from mitochondria to the cytosol are involved in arsenite-induced apoptosis, and Bcl-2 antagonize arsenite-induced apoptosis by a mechanism that interferes in the activity of CPP32.	arsenite	147-155	BCL2 apoptosis regulator	Homo sapiens	179-184
9766529-7	1998	Activation of CPP32 activity, PARP (a DNA repair enzyme) degradation, and release of cytochrome c from mitochondria to the cytosol are involved in arsenite-induced apoptosis, and Bcl-2 antagonize arsenite-induced apoptosis by a mechanism that interferes in the activity of CPP32.	arsenite	147-155	caspase 3	Homo sapiens	273-278
9766529-7	1998	Activation of CPP32 activity, PARP (a DNA repair enzyme) degradation, and release of cytochrome c from mitochondria to the cytosol are involved in arsenite-induced apoptosis, and Bcl-2 antagonize arsenite-induced apoptosis by a mechanism that interferes in the activity of CPP32.	arsenite	196-204	caspase 3	Homo sapiens	14-19
9766529-7	1998	Activation of CPP32 activity, PARP (a DNA repair enzyme) degradation, and release of cytochrome c from mitochondria to the cytosol are involved in arsenite-induced apoptosis, and Bcl-2 antagonize arsenite-induced apoptosis by a mechanism that interferes in the activity of CPP32.	arsenite	196-204	BCL2 apoptosis regulator	Homo sapiens	179-184
9766529-8	1998	These results lead to a working hypothesis that arsenite-induced apoptosis is triggered by the generation of hydrogen peroxide through activation of flavoprotein-dependent superoxide-producing enzymes (such as NADPH oxidase), and hydrogen peroxide might play a role as a mediator to induce apoptosis through release of cytochrome c to cytosol, activation of CPP32 protease, and PARP degradation.	arsenite	48-56	cytochrome c, somatic	Homo sapiens	319-331
9766529-8	1998	These results lead to a working hypothesis that arsenite-induced apoptosis is triggered by the generation of hydrogen peroxide through activation of flavoprotein-dependent superoxide-producing enzymes (such as NADPH oxidase), and hydrogen peroxide might play a role as a mediator to induce apoptosis through release of cytochrome c to cytosol, activation of CPP32 protease, and PARP degradation.	arsenite	48-56	caspase 3	Homo sapiens	358-363
9766529-8	1998	These results lead to a working hypothesis that arsenite-induced apoptosis is triggered by the generation of hydrogen peroxide through activation of flavoprotein-dependent superoxide-producing enzymes (such as NADPH oxidase), and hydrogen peroxide might play a role as a mediator to induce apoptosis through release of cytochrome c to cytosol, activation of CPP32 protease, and PARP degradation.	arsenite	48-56	collagen type XI alpha 2 chain	Homo sapiens	378-382
9848127-12	1998	Arsenite (1 microM) alone modestly increased c-myc expression from 1 to 4 h after treatment (maximum of 2.0-fold over control).	arsenite	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	45-50
9848127-13	1998	After GSH depletion cells responded to arsenite exposure with much larger increases in c-myc transcription (3.2-fold over control).	arsenite	39-47	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	87-92
9722676-4	1998	Genistein (50 microM), another tyrosine kinase inhibitor, also inhibited the induction of HO-1 mRNA by hemin, arsenite, and cadmium.	arsenite	110-118	heme oxygenase 1	Homo sapiens	90-94
9784401-2	1998	We report the induction of HO1 in human lymphoblastoid cells (LBs) by arsenite in a dose-related manner.	arsenite	70-78	heme oxygenase 1	Homo sapiens	27-30
9784401-4	1998	HO1 levels in LBs treated with arsenite increased by de novo synthesis as demonstrated by incorporation of 35S-methionine and by inhibition of HO1 synthesis by actinomycin D.	arsenite	31-39	heme oxygenase 1	Homo sapiens	0-3
9784401-4	1998	HO1 levels in LBs treated with arsenite increased by de novo synthesis as demonstrated by incorporation of 35S-methionine and by inhibition of HO1 synthesis by actinomycin D.	arsenite	31-39	heme oxygenase 1	Homo sapiens	143-146
9722676-3	1998	Herbimycin also inhibited arsenite- and cadmium-dependent induction of HO-1 mRNA in a dose-dependent manner, but less inhibition was observed in cadmium-treated cells than in ones treated with hemin- or arsenite.	arsenite	26-34	heme oxygenase 1	Homo sapiens	71-75
9710602-0	1998	Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc.	arsenite	15-23	Eph receptor B1	Rattus norvegicus	34-71
9710602-0	1998	Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc.	arsenite	15-23	epidermal growth factor receptor	Rattus norvegicus	112-144
9710602-2	1998	Previously, we reported that arsenite treatment leads to the activation of the extracellular signal-regulated kinase (ERK) in rat PC12 cells through a Ras-dependent pathway.	arsenite	29-37	Eph receptor B1	Rattus norvegicus	79-116
9710602-2	1998	Previously, we reported that arsenite treatment leads to the activation of the extracellular signal-regulated kinase (ERK) in rat PC12 cells through a Ras-dependent pathway.	arsenite	29-37	Eph receptor B1	Rattus norvegicus	118-121
9710602-4	1998	Arsenite treatment rapidly stimulated tyrosine phosphorylation of several proteins in a Ras-independent manner, with a pattern similar to that seen in response to epidermal growth factor (EGF) treatment.	arsenite	0-8	epidermal growth factor like 1	Rattus norvegicus	188-191
9710602-7	1998	The arsenite-induced tyrosine phosphorylation of Shc, enhancement of Shc and Grb2 interactions, and activation of ERK were all drastically reduced by treatment of cells with either the general growth factor receptor poison suramin or the EGFR-selective inhibitor tyrphostin AG1478.	arsenite	4-12	growth factor receptor bound protein 2	Rattus norvegicus	77-81
9710602-7	1998	The arsenite-induced tyrosine phosphorylation of Shc, enhancement of Shc and Grb2 interactions, and activation of ERK were all drastically reduced by treatment of cells with either the general growth factor receptor poison suramin or the EGFR-selective inhibitor tyrphostin AG1478.	arsenite	4-12	Eph receptor B1	Rattus norvegicus	114-117
9710602-7	1998	The arsenite-induced tyrosine phosphorylation of Shc, enhancement of Shc and Grb2 interactions, and activation of ERK were all drastically reduced by treatment of cells with either the general growth factor receptor poison suramin or the EGFR-selective inhibitor tyrphostin AG1478.	arsenite	4-12	epidermal growth factor receptor	Rattus norvegicus	238-242
9710602-8	1998	Down-regulation of EGFR expression through pretreatment of cells with EGF also attenuated ERK activation and Shc tyrosine phosphorylation in response to arsenite treatment.	arsenite	153-161	epidermal growth factor receptor	Rattus norvegicus	19-23
9710602-8	1998	Down-regulation of EGFR expression through pretreatment of cells with EGF also attenuated ERK activation and Shc tyrosine phosphorylation in response to arsenite treatment.	arsenite	153-161	epidermal growth factor like 1	Rattus norvegicus	19-22
9710602-8	1998	Down-regulation of EGFR expression through pretreatment of cells with EGF also attenuated ERK activation and Shc tyrosine phosphorylation in response to arsenite treatment.	arsenite	153-161	Eph receptor B1	Rattus norvegicus	90-93
9710602-9	1998	These results demonstrate that the EGFR and Shc are critical mediators in the activation of the Ras/ERK signaling cascade by arsenite and suggest that arsenite acts as a tumor promoter largely by usurping this growth factor signaling pathway.	arsenite	125-133	epidermal growth factor receptor	Rattus norvegicus	35-39
9710602-9	1998	These results demonstrate that the EGFR and Shc are critical mediators in the activation of the Ras/ERK signaling cascade by arsenite and suggest that arsenite acts as a tumor promoter largely by usurping this growth factor signaling pathway.	arsenite	125-133	Eph receptor B1	Rattus norvegicus	100-103
9710602-9	1998	These results demonstrate that the EGFR and Shc are critical mediators in the activation of the Ras/ERK signaling cascade by arsenite and suggest that arsenite acts as a tumor promoter largely by usurping this growth factor signaling pathway.	arsenite	151-159	epidermal growth factor receptor	Rattus norvegicus	35-39
9710602-9	1998	These results demonstrate that the EGFR and Shc are critical mediators in the activation of the Ras/ERK signaling cascade by arsenite and suggest that arsenite acts as a tumor promoter largely by usurping this growth factor signaling pathway.	arsenite	151-159	Eph receptor B1	Rattus norvegicus	100-103
10696239-1	1998	The hASNA-I is a novel human arsenite-stimulated ATPase identified as the human paralogue of the ATPase component of the arsenite efflux system in E. coli.	arsenite	29-37	guided entry of tail-anchored proteins factor 3, ATPase	Homo sapiens	4-11
10696239-1	1998	The hASNA-I is a novel human arsenite-stimulated ATPase identified as the human paralogue of the ATPase component of the arsenite efflux system in E. coli.	arsenite	29-37	dynein axonemal heavy chain 8	Homo sapiens	49-55
10696239-1	1998	The hASNA-I is a novel human arsenite-stimulated ATPase identified as the human paralogue of the ATPase component of the arsenite efflux system in E. coli.	arsenite	29-37	dynein axonemal heavy chain 8	Homo sapiens	97-103
9712828-5	1998	The GST-hASNA-I exhibited a basal level of ATPase activity of 18.5 +/- 8 nmol/min/mg in the absence of arsenite.	arsenite	103-111	guided entry of tail-anchored proteins factor 3, ATPase	Homo sapiens	8-15
9722676-8	1998	When HeLa cells were treated with a specific inhibitor of the mitogen-activated protein kinase (MAPK)/extracellular-signal regulated kinase cascade, PD58059 (100 microM), suppression of the cadmium-dependent HO-1 induction was not observed, but the hemin- or arsenite-dependent induction was slightly inhibited.	arsenite	259-267	heme oxygenase 1	Homo sapiens	208-212
9671371-13	1998	Conversely, cells exposed to cytokines or LPS before arsenite had the highest number of bacteria crossing the monolayer (p < .05).	arsenite	53-61	interferon regulatory factor 6	Homo sapiens	42-45
9671371-14	1998	CONCLUSIONS: These results indicate that preinduction of a heat-shock response (arsenite) can protect against cytokine or LPS-induced apoptosis and enterocyte dysfunction, as manifested by the passage of E. coli across an intact enterocyte monolayer.	arsenite	80-88	interferon regulatory factor 6	Homo sapiens	122-125
9688289-4	1998	These results not only suggested that both arsenite and arsenate induced apoptosis of NB4 cells through 2 different mechanisms--at low doses, arsenical might directly induce apoptosis through regulation of cell cycle checkpoint, while at high doses they might directly induce it, but also indicated that bcl-2 might not play an important role in arsenite or arsenate-induced apoptosis of NB4 cells, whereas chemical valence of As in a compound might be related to efficiency in arsenical induction of apoptosis.	arsenite	43-51	BCL2 apoptosis regulator	Homo sapiens	304-309
9650071-3	1998	Oxidative stress caused by treatment of the cells with diamide, arsenite, or hydrogen peroxide leads to an increase in Hsp25-dimerisation which can be blocked by simultaneous treatment with reducing agents.	arsenite	64-72	heat shock protein 1	Mus musculus	119-124
9548797-5	1998	This strong cytotoxicity of an inorganic arsenical, arsenite, might be mediated via active oxygen and protease activation because it was inhibited by the addition of some antioxidant reagents, such as superoxide dismutase (SOD), catalase, and GSH, or by a peptide inhibitor of interleukin-1 beta-converting enzyme (ICE).	arsenite	52-60	catalase	Mus musculus	229-237
9551088-3	1998	The HSE-binding activity of HSF1 was induced by a number of chemical stresses including cadmium, aluminum, iron, mercury, arsenite, ethanol, methanol, and salicylate.	arsenite	122-130	heat shock factor protein	Xenopus laevis	28-32
9551088-6	1998	The transcriptional activity of oocyte HSF1 was induced by heat, cadmium, and arsenite, but many of the agents that induced HSE-binding failed to stimulate HSF1-mediated transcription.	arsenite	78-86	heat shock factor protein	Xenopus laevis	39-43
9442025-0	1998	The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway.	arsenite	19-27	mitogen-activated protein kinase 3	Homo sapiens	72-118
9442025-0	1998	The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway.	arsenite	19-27	mitogen-activated protein kinase 3	Homo sapiens	125-129
9442025-0	1998	The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway.	arsenite	19-27	mitogen-activated protein kinase 1	Homo sapiens	139-142
9442025-3	1998	We show here that the stress cascade activator arsenite activates extracellular signal-regulated kinase (ERK) in addition to p38 albeit with different kinetics.	arsenite	47-55	mitogen-activated protein kinase 1	Homo sapiens	66-103
9442025-3	1998	We show here that the stress cascade activator arsenite activates extracellular signal-regulated kinase (ERK) in addition to p38 albeit with different kinetics.	arsenite	47-55	mitogen-activated protein kinase 1	Homo sapiens	105-108
9442025-3	1998	We show here that the stress cascade activator arsenite activates extracellular signal-regulated kinase (ERK) in addition to p38 albeit with different kinetics.	arsenite	47-55	mitogen-activated protein kinase 1	Homo sapiens	125-128
9442025-4	1998	Whereas p38 is an early response kinase, ERK activation occurs with delayed time kinetics at 2-4 h. We observed activation of ERK upon arsenite treatment in many different cell lines.	arsenite	135-143	mitogen-activated protein kinase 1	Homo sapiens	8-11
9442025-4	1998	Whereas p38 is an early response kinase, ERK activation occurs with delayed time kinetics at 2-4 h. We observed activation of ERK upon arsenite treatment in many different cell lines.	arsenite	135-143	mitogen-activated protein kinase 1	Homo sapiens	41-44
9442025-4	1998	Whereas p38 is an early response kinase, ERK activation occurs with delayed time kinetics at 2-4 h. We observed activation of ERK upon arsenite treatment in many different cell lines.	arsenite	135-143	mitogen-activated protein kinase 1	Homo sapiens	126-129
9442025-6	1998	Arsenite-induced ERK activation is mediated by Ras, Raf, and MEK but appears to be independent of de novo protein synthesis.	arsenite	0-8	mitogen-activated protein kinase 1	Homo sapiens	17-20
9442025-6	1998	Arsenite-induced ERK activation is mediated by Ras, Raf, and MEK but appears to be independent of de novo protein synthesis.	arsenite	0-8	zinc fingers and homeoboxes 2	Homo sapiens	52-55
9442025-6	1998	Arsenite-induced ERK activation is mediated by Ras, Raf, and MEK but appears to be independent of de novo protein synthesis.	arsenite	0-8	mitogen-activated protein kinase kinase 7	Homo sapiens	61-64
9545260-5	1998	Cell stresses such as arsenite and anisomycin and the cytokines tumor necrosis factor-alpha and interleukin-1beta also cause increased phosphorylation of eIF4E, which is abolished by the specific p38 MAP kinase inhibitor, SB203580.	arsenite	22-30	tumor necrosis factor	Homo sapiens	64-91
9545260-5	1998	Cell stresses such as arsenite and anisomycin and the cytokines tumor necrosis factor-alpha and interleukin-1beta also cause increased phosphorylation of eIF4E, which is abolished by the specific p38 MAP kinase inhibitor, SB203580.	arsenite	22-30	interleukin 1 beta	Homo sapiens	96-113
9545260-5	1998	Cell stresses such as arsenite and anisomycin and the cytokines tumor necrosis factor-alpha and interleukin-1beta also cause increased phosphorylation of eIF4E, which is abolished by the specific p38 MAP kinase inhibitor, SB203580.	arsenite	22-30	eukaryotic translation initiation factor 4E	Homo sapiens	154-159
9545260-5	1998	Cell stresses such as arsenite and anisomycin and the cytokines tumor necrosis factor-alpha and interleukin-1beta also cause increased phosphorylation of eIF4E, which is abolished by the specific p38 MAP kinase inhibitor, SB203580.	arsenite	22-30	mitogen-activated protein kinase 14	Homo sapiens	196-199
9535875-5	1998	This construct was used to investigate the role of mitogen-activated protein (MAP) kinases in arsenite-mediated heme oxygenase-1 gene expression.	arsenite	94-102	heme oxygenase 1	Gallus gallus	112-128
9535875-8	1998	Involvement of an AP-1 site in arsenite induction of heme oxygenase-1 gene expression was studied.	arsenite	31-39	heme oxygenase 1	Gallus gallus	53-69
9506981-3	1998	A second site revertant (A344V) adjacent to the C-terminal nucleotide binding site was previously shown to restore arsenite resistance, suggesting the interaction of the nucleotide binding sites in ArsA (Li, J., Liu, S., and Rosen, B. P. (1996) J. Biol.	arsenite	115-123	arylsulfatase A	Homo sapiens	198-202
9448725-0	1998	Inhibition of NF-kappa B binding to DNA by chromium, cadmium, mercury, zinc, and arsenite in vitro: evidence of a thiol mechanism.	arsenite	81-89	nuclear factor kappa B subunit 1	Homo sapiens	14-24
9448725-2	1998	Gel mobility shift assays using total nuclear extracts isolated from tumor necrosis factor alpha-treated A549 cells demonstrated dose-dependent inhibition of NF-kappa B binding by chromium, cadmium, mercury, zinc, and arsenite.	arsenite	218-226	tumor necrosis factor	Homo sapiens	69-96
9448725-2	1998	Gel mobility shift assays using total nuclear extracts isolated from tumor necrosis factor alpha-treated A549 cells demonstrated dose-dependent inhibition of NF-kappa B binding by chromium, cadmium, mercury, zinc, and arsenite.	arsenite	218-226	nuclear factor kappa B subunit 1	Homo sapiens	158-168
9548797-5	1998	This strong cytotoxicity of an inorganic arsenical, arsenite, might be mediated via active oxygen and protease activation because it was inhibited by the addition of some antioxidant reagents, such as superoxide dismutase (SOD), catalase, and GSH, or by a peptide inhibitor of interleukin-1 beta-converting enzyme (ICE).	arsenite	52-60	caspase 1	Mus musculus	277-313
9548797-5	1998	This strong cytotoxicity of an inorganic arsenical, arsenite, might be mediated via active oxygen and protease activation because it was inhibited by the addition of some antioxidant reagents, such as superoxide dismutase (SOD), catalase, and GSH, or by a peptide inhibitor of interleukin-1 beta-converting enzyme (ICE).	arsenite	52-60	caspase 1	Mus musculus	315-318
9369529-5	1997	Arsenite-treated retinas displayed hsp70-like immunoreactivity in a pattern that was also like that of control retinas.	arsenite	0-8	heat shock 70kDa protein L homeolog	Xenopus laevis	35-40
9374482-11	1997	However, the high dosage of ACR3 gene resulted in loss of arsenite uptake.	arsenite	58-66	Arr3p	Saccharomyces cerevisiae S288C	28-32
9374482-12	1997	These results suggest that arsenite resistance in yeast is mediated by an arsenite transporter (Acr3p).	arsenite	27-35	Arr3p	Saccharomyces cerevisiae S288C	96-101
9368070-1	1997	Phosphorylation of alphaB-crystallin, a member of the hsp27 family, in human glioma (U373 MG) cells was stimulated by exposure of the cells to various stimuli, which included heat, arsenite, phorbol 12-myristate 13-acetate (PMA), okadaic acid, H2O2, anisomycin, and high concentrations of NaCl or sorbitol, but not in response to agents that elevated intracellular levels of cyclic AMP.	arsenite	181-189	crystallin, alpha B	Rattus norvegicus	19-36
9368070-8	1997	Although PMA and arsenite preferentially stimulated the phosphorylation of Ser-45 and Ser-59, respectively, as determined with antibodies that recognized the respective phosphorylated forms of alphaB-crystallin, all three sites were phosphorylated in response to each stimulus.	arsenite	17-25	crystallin, alpha B	Rattus norvegicus	193-210
9371502-5	1997	Arsenite-induced G2 and mitotic delay are accompanied by accumulation of cyclin B1 and hyperphosphorylation of cdc2 and Mos proteins.	arsenite	0-8	cyclin B1	Homo sapiens	73-82
9371502-5	1997	Arsenite-induced G2 and mitotic delay are accompanied by accumulation of cyclin B1 and hyperphosphorylation of cdc2 and Mos proteins.	arsenite	0-8	cyclin dependent kinase 1	Homo sapiens	111-115
9371502-5	1997	Arsenite-induced G2 and mitotic delay are accompanied by accumulation of cyclin B1 and hyperphosphorylation of cdc2 and Mos proteins.	arsenite	0-8	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	120-123
9299480-2	1997	Unexpectedly, we have found that, in adult rat cardiomyocytes, arsenite, which generally induces stress responses, markedly and rapidly activates p70 S6k.	arsenite	63-71	ribosomal protein S6 kinase B1	Rattus norvegicus	146-153
9374482-0	1997	The Saccharomyces cerevisiae ACR3 gene encodes a putative membrane protein involved in arsenite transport.	arsenite	87-95	Arr3p	Saccharomyces cerevisiae S288C	29-33
9374482-2	1997	The overexpression of ACR3 induced high level arsenite resistance.	arsenite	46-54	Arr3p	Saccharomyces cerevisiae S288C	22-26
9299480-4	1997	In trying to delineate the mechanism underlying this effect, we found that arsenite did not activate protein kinase B, JNK or MAP kinase, but did activate p38 MAP kinase in cardiac myocytes.	arsenite	75-83	mitogen activated protein kinase 14	Rattus norvegicus	155-158
9299480-5	1997	A specific inhibitor of p38 MAP kinase (SB203580) partially attenuated the stimulation of p70 S6k by arsenite.	arsenite	101-109	mitogen activated protein kinase 14	Rattus norvegicus	24-27
9299480-5	1997	A specific inhibitor of p38 MAP kinase (SB203580) partially attenuated the stimulation of p70 S6k by arsenite.	arsenite	101-109	ribosomal protein S6 kinase B1	Rattus norvegicus	90-97
9299480-6	1997	These data indicate that the activation of p70 S6k by arsenite involves p38 MAP kinase and phosphatidylinositol 3-kinase but not PKB.	arsenite	54-62	ribosomal protein S6 kinase B1	Rattus norvegicus	43-50
9299480-6	1997	These data indicate that the activation of p70 S6k by arsenite involves p38 MAP kinase and phosphatidylinositol 3-kinase but not PKB.	arsenite	54-62	mitogen activated protein kinase 14	Rattus norvegicus	72-75
9314608-4	1997	The enhanced expression of mRNAs for hsp27, alpha B crystallin and hsp70, as well as the prolonged activation of heat shock transcription factor 1 (HSF1), were also observed in cells that had been treated with arsenite in the presence of 0.05 mM dithiothreitol.	arsenite	210-218	heat shock protein family B (small) member 1	Rattus norvegicus	37-42
9231701-0	1997	Glutathione peroxidase and catalase modulate the genotoxicity of arsenite.	arsenite	65-73	catalase	Cricetulus griseus	27-35
9231701-5	1997	The addition of catalase or glutathione peroxidase to cultures reduced the arsenite-induced micronuclei in xrs-5 cells.	arsenite	75-83	catalase	Cricetulus griseus	16-24
9231701-6	1997	Whereas, simultaneous treatment with mercaptosuccinate, an inhibitor of glutathione peroxidase, and 3-aminotriazole, an inhibitor of catalase, synergistically increased the arsenite-induced micronuclei.	arsenite	173-181	catalase	Cricetulus griseus	133-141
9231701-7	1997	These results suggest that both catalase and glutathione peroxidase are involved in defense against arsenite genotoxicity.	arsenite	100-108	catalase	Cricetulus griseus	32-40
9231701-10	1997	These results suggest that glutathione peroxidase is more important than catalase in defending against arsenite toxicity.	arsenite	103-111	catalase	Cricetulus griseus	73-81
9314608-4	1997	The enhanced expression of mRNAs for hsp27, alpha B crystallin and hsp70, as well as the prolonged activation of heat shock transcription factor 1 (HSF1), were also observed in cells that had been treated with arsenite in the presence of 0.05 mM dithiothreitol.	arsenite	210-218	crystallin, alpha B	Rattus norvegicus	44-62
9314608-4	1997	The enhanced expression of mRNAs for hsp27, alpha B crystallin and hsp70, as well as the prolonged activation of heat shock transcription factor 1 (HSF1), were also observed in cells that had been treated with arsenite in the presence of 0.05 mM dithiothreitol.	arsenite	210-218	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	67-72
9314608-4	1997	The enhanced expression of mRNAs for hsp27, alpha B crystallin and hsp70, as well as the prolonged activation of heat shock transcription factor 1 (HSF1), were also observed in cells that had been treated with arsenite in the presence of 0.05 mM dithiothreitol.	arsenite	210-218	heat shock transcription factor 1	Rattus norvegicus	113-146
9314608-4	1997	The enhanced expression of mRNAs for hsp27, alpha B crystallin and hsp70, as well as the prolonged activation of heat shock transcription factor 1 (HSF1), were also observed in cells that had been treated with arsenite in the presence of 0.05 mM dithiothreitol.	arsenite	210-218	heat shock transcription factor 1	Rattus norvegicus	148-152
9252422-6	1997	Cellular stresses that trigger the activation of SAPK2 and MAPKAP kinase-2 (arsenite, heat shock) also stimulated IUF1 binding to DNA and IUF1-dependent gene transcription, and these effects were also prevented by SB 203580.	arsenite	76-84	mitogen-activated protein kinase 11	Homo sapiens	49-54
9271073-4	1997	ArsA, ArsB, and ArsC form a protein pump system that extrudes antimonite, arsenite, and arsenate once these anions reach the cytoplasm of the bacterium.	arsenite	74-82	arylsulfatase A	Homo sapiens	0-4
9271073-4	1997	ArsA, ArsB, and ArsC form a protein pump system that extrudes antimonite, arsenite, and arsenate once these anions reach the cytoplasm of the bacterium.	arsenite	74-82	arylsulfatase B	Homo sapiens	6-10
9271073-4	1997	ArsA, ArsB, and ArsC form a protein pump system that extrudes antimonite, arsenite, and arsenate once these anions reach the cytoplasm of the bacterium.	arsenite	74-82	steroid sulfatase	Homo sapiens	16-20
9252422-6	1997	Cellular stresses that trigger the activation of SAPK2 and MAPKAP kinase-2 (arsenite, heat shock) also stimulated IUF1 binding to DNA and IUF1-dependent gene transcription, and these effects were also prevented by SB 203580.	arsenite	76-84	MAPK activated protein kinase 2	Homo sapiens	59-74
9252422-6	1997	Cellular stresses that trigger the activation of SAPK2 and MAPKAP kinase-2 (arsenite, heat shock) also stimulated IUF1 binding to DNA and IUF1-dependent gene transcription, and these effects were also prevented by SB 203580.	arsenite	76-84	pancreatic and duodenal homeobox 1	Homo sapiens	114-118
9252422-6	1997	Cellular stresses that trigger the activation of SAPK2 and MAPKAP kinase-2 (arsenite, heat shock) also stimulated IUF1 binding to DNA and IUF1-dependent gene transcription, and these effects were also prevented by SB 203580.	arsenite	76-84	pancreatic and duodenal homeobox 1	Homo sapiens	138-142
9261921-1	1997	In a previous study, we found that sodium arsenite increased hepatic ornithine decarboxylase (ODC) activity and hepatic heme oxygenase (HO) activity, but did not cause any DNA damage in adult female rat liver or lung, suggesting that arsenite may be a promoter of carcinogenesis.	arsenite	42-50	ornithine decarboxylase 1	Rattus norvegicus	69-92
9139689-4	1997	Arsenite or osmotic stress potently activated p38 but were ineffective in inducing NF-kappaB activation.	arsenite	0-8	mitogen-activated protein kinase 14	Homo sapiens	46-49
9145211-2	1997	A significant induction of Hsp72 in the cells was observed by exposure to 10mM DMAA for 6 h. The induction was similar to the case by arsenite for 6 h or by heat treatment at 42 degrees C for 3h.	arsenite	134-142	heat shock protein family A (Hsp70) member 1A	Homo sapiens	27-32
9145211-3	1997	However, the nuclear distribution of Hsp72 differed greatly between DMAA and 42 degrees C treatment or arsenite exposure, i.e., Hsp72 induced by exposure to DMAA accumulated not only in the nucleoli but also in the nucleoplasm, whereas that by 42 degrees C or arsenite exposure did not accumulate in the nucleoplasm.	arsenite	103-111	heat shock protein family A (Hsp70) member 1A	Homo sapiens	37-42
9145211-3	1997	However, the nuclear distribution of Hsp72 differed greatly between DMAA and 42 degrees C treatment or arsenite exposure, i.e., Hsp72 induced by exposure to DMAA accumulated not only in the nucleoli but also in the nucleoplasm, whereas that by 42 degrees C or arsenite exposure did not accumulate in the nucleoplasm.	arsenite	103-111	heat shock protein family A (Hsp70) member 1A	Homo sapiens	128-133
9145211-3	1997	However, the nuclear distribution of Hsp72 differed greatly between DMAA and 42 degrees C treatment or arsenite exposure, i.e., Hsp72 induced by exposure to DMAA accumulated not only in the nucleoli but also in the nucleoplasm, whereas that by 42 degrees C or arsenite exposure did not accumulate in the nucleoplasm.	arsenite	260-268	heat shock protein family A (Hsp70) member 1A	Homo sapiens	37-42
9145211-3	1997	However, the nuclear distribution of Hsp72 differed greatly between DMAA and 42 degrees C treatment or arsenite exposure, i.e., Hsp72 induced by exposure to DMAA accumulated not only in the nucleoli but also in the nucleoplasm, whereas that by 42 degrees C or arsenite exposure did not accumulate in the nucleoplasm.	arsenite	260-268	heat shock protein family A (Hsp70) member 1A	Homo sapiens	128-133
9066782-6	1997	When cells were exposed to arsenite in the presence of 10-40 microM prostaglandin, the accumulation of hsp27 and alpha B crystallin in cells was enhanced markedly.	arsenite	27-35	heat shock protein family B (small) member 1	Rattus norvegicus	103-108
9066782-6	1997	When cells were exposed to arsenite in the presence of 10-40 microM prostaglandin, the accumulation of hsp27 and alpha B crystallin in cells was enhanced markedly.	arsenite	27-35	crystallin, alpha B	Rattus norvegicus	113-131
9066782-7	1997	The levels of hsp70 also increased in cells that had been treated with arsenite in the presence of a prostaglandin, as estimated by Western blot analysis.	arsenite	71-79	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	14-19
9066782-8	1997	Northern blot analysis revealed that the expression of messenger RNAs (mRNAs) for hsp27, alpha B crystallin, and hsp70 was enhanced in cells that had been exposed to arsenite in the presence of each prostaglandin.	arsenite	166-174	heat shock protein family B (small) member 1	Rattus norvegicus	82-96
9066782-8	1997	Northern blot analysis revealed that the expression of messenger RNAs (mRNAs) for hsp27, alpha B crystallin, and hsp70 was enhanced in cells that had been exposed to arsenite in the presence of each prostaglandin.	arsenite	166-174	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	113-118
9249041-7	1997	This activation was due to a rise in the number of cell-surface glucose transporters, based on an increase in the Vmax of glucose transport and the observation that arsenite increases the plasma membrane content of GLUT1 and GLUT4 glucose transporters by 95% and 60%, respectively, from an intracellular compartment.	arsenite	165-173	solute carrier family 2 member 1	Rattus norvegicus	215-220
9249041-7	1997	This activation was due to a rise in the number of cell-surface glucose transporters, based on an increase in the Vmax of glucose transport and the observation that arsenite increases the plasma membrane content of GLUT1 and GLUT4 glucose transporters by 95% and 60%, respectively, from an intracellular compartment.	arsenite	165-173	solute carrier family 2 member 4	Rattus norvegicus	225-230
9234670-4	1997	Disruption of the ACR1 gene conduces to an arsenite and arsenate hypersensitivity phenotype.	arsenite	43-51	Arr1p	Saccharomyces cerevisiae S288C	18-22
9234670-7	1997	Overexpression of the ACR3 gene confers an arsenite- but not an arsenate-resistance phenotype.	arsenite	43-51	Arr3p	Saccharomyces cerevisiae S288C	22-26
9219564-5	1997	In experiments with arsenite, DNA sequencing using bisulfite to visualize 5-methylcytosine (5-MeC) over the entire promoter region confirmed data obtained by restriction analysis.	arsenite	20-28	C-C motif chemokine ligand 28	Homo sapiens	94-97
9219571-0	1997	Inhibition of poly(ADP-ribose) polymerase by arsenite.	arsenite	45-53	poly(ADP-ribose) polymerase 1	Homo sapiens	14-41
9219571-12	1997	Results show that arsenite decreases PARP activity in a dose-dependent manner with an approximately 50% decrease in enzyme activity at 10 microM arsenite and 80% viability.	arsenite	18-26	poly(ADP-ribose) polymerase 1	Homo sapiens	37-41
9219571-12	1997	Results show that arsenite decreases PARP activity in a dose-dependent manner with an approximately 50% decrease in enzyme activity at 10 microM arsenite and 80% viability.	arsenite	145-153	poly(ADP-ribose) polymerase 1	Homo sapiens	37-41
9219571-14	1997	These results provide further indication that arsenite may potentiate genetic damage through reaction with dithiols in DNA repair proteins such as PARP, perhaps resulting in interference with normal repair function.	arsenite	46-54	poly(ADP-ribose) polymerase 1	Homo sapiens	147-151
9261921-1	1997	In a previous study, we found that sodium arsenite increased hepatic ornithine decarboxylase (ODC) activity and hepatic heme oxygenase (HO) activity, but did not cause any DNA damage in adult female rat liver or lung, suggesting that arsenite may be a promoter of carcinogenesis.	arsenite	42-50	ornithine decarboxylase 1	Rattus norvegicus	94-97
8997314-6	1996	Arsenite pretreatment resulted in expression of HSP 70 mRNA and of HSP 70 and heme oxygenase-1 proteins, inhibition of LPS-mediated iNOS mRNA induction, reversal of the LPS-induced hyporesponsiveness to norepinephrine ex vivo in isolated mesenteric arteries, and attenuation of LPS-induced hypotension in vivo.	arsenite	0-8	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	48-54
8997314-6	1996	Arsenite pretreatment resulted in expression of HSP 70 mRNA and of HSP 70 and heme oxygenase-1 proteins, inhibition of LPS-mediated iNOS mRNA induction, reversal of the LPS-induced hyporesponsiveness to norepinephrine ex vivo in isolated mesenteric arteries, and attenuation of LPS-induced hypotension in vivo.	arsenite	0-8	heme oxygenase 1	Rattus norvegicus	78-94
8997314-6	1996	Arsenite pretreatment resulted in expression of HSP 70 mRNA and of HSP 70 and heme oxygenase-1 proteins, inhibition of LPS-mediated iNOS mRNA induction, reversal of the LPS-induced hyporesponsiveness to norepinephrine ex vivo in isolated mesenteric arteries, and attenuation of LPS-induced hypotension in vivo.	arsenite	0-8	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	67-73
8997314-6	1996	Arsenite pretreatment resulted in expression of HSP 70 mRNA and of HSP 70 and heme oxygenase-1 proteins, inhibition of LPS-mediated iNOS mRNA induction, reversal of the LPS-induced hyporesponsiveness to norepinephrine ex vivo in isolated mesenteric arteries, and attenuation of LPS-induced hypotension in vivo.	arsenite	0-8	nitric oxide synthase 2	Rattus norvegicus	132-136
8706660-4	1996	Cross-linking of mitochondrial dithiols with arsenite or phenylarsine oxide, or treatment with tert-butylhydroperoxide leading to complete oxidation of glutathione, increased the sensitivity of MTP opening to Ca2+.	arsenite	45-53	microsomal triglyceride transfer protein	Rattus norvegicus	194-197
8947035-5	1996	Targeted inactivation of mrp-l resulted in increased sensitivity to the heavy metal ions cadmium and arsenite, to which wild-type worms are highly tolerant.	arsenite	101-109	ATP binding cassette subfamily C member 1	Homo sapiens	25-28
8991852-7	1996	The arsenic resistance efflux system transports arsenite [As(III)], alternatively using either a double-polypeptide (ArsA and ArsB) ATPase or a single-polypeptide (ArsB) functioning as a chemiosmotic transporter.	arsenite	48-56	arylsulfatase A	Homo sapiens	117-121
8991852-7	1996	The arsenic resistance efflux system transports arsenite [As(III)], alternatively using either a double-polypeptide (ArsA and ArsB) ATPase or a single-polypeptide (ArsB) functioning as a chemiosmotic transporter.	arsenite	48-56	arylsulfatase B	Homo sapiens	126-130
8991852-7	1996	The arsenic resistance efflux system transports arsenite [As(III)], alternatively using either a double-polypeptide (ArsA and ArsB) ATPase or a single-polypeptide (ArsB) functioning as a chemiosmotic transporter.	arsenite	48-56	dynein axonemal heavy chain 8	Homo sapiens	132-138
8991852-7	1996	The arsenic resistance efflux system transports arsenite [As(III)], alternatively using either a double-polypeptide (ArsA and ArsB) ATPase or a single-polypeptide (ArsB) functioning as a chemiosmotic transporter.	arsenite	48-56	arylsulfatase B	Homo sapiens	164-168
8991852-8	1996	The third gene in the arsenic resistance system, arsC, encodes an enzyme that converts intracellular arsenate [As(V)] to arsenite [As(III)], the substrate of the efflux system.	arsenite	121-129	steroid sulfatase	Homo sapiens	49-53
8841493-0	1996	Polymerase chain reaction-based deletion analysis of spontaneous and arsenite-enhanced gpt mutants in CHO-AS52 cells.	arsenite	69-77	alanine aminotransferase 1	Cricetulus griseus	87-90
8841493-2	1996	Our results provide very weak evidence for arsenite as a gene mutagen because the chemical at high doses and at high cytotoxicity enhances barely a doubling of mutant frequency (MF) and a doubling of the gpt gene deletion frequency compared to controls.	arsenite	43-51	alanine aminotransferase 1	Cricetulus griseus	204-207
8841493-5	1996	For the spontaneous, 50 microM arsenite- and 100 microM arsenite-enhanced spontaneous mutants in AS52 cells, the percentages of total deletion of the gpt gene are 36.00%, 54.72% and 66.67%, respectively.	arsenite	31-39	alanine aminotransferase 1	Cricetulus griseus	150-153
8836877-1	1996	Exposure of osteoblast-like MC3T3-E1 cells to sodium arsenite (arsenite) increased the level of heat shock protein 27 (hsp27).	arsenite	53-61	heat shock protein 1	Mus musculus	96-117
8836877-1	1996	Exposure of osteoblast-like MC3T3-E1 cells to sodium arsenite (arsenite) increased the level of heat shock protein 27 (hsp27).	arsenite	53-61	heat shock protein 1	Mus musculus	119-124
8836877-4	1996	Both indomethacin, an inhibitor of cyclooxygenase, and nordihydroguaiaretic acid, a lipoxygenase inhibitor, significantly enhanced the arsenite-induced accumulation of hsp27.	arsenite	135-143	heat shock protein 1	Mus musculus	168-173
8836877-5	1996	Melittin, an activator of phospholipase A2, significantly enhanced the arsenite-induced accumulation of hsp27.	arsenite	71-79	phospholipase A2, group IB, pancreas	Mus musculus	26-42
8836877-5	1996	Melittin, an activator of phospholipase A2, significantly enhanced the arsenite-induced accumulation of hsp27.	arsenite	71-79	heat shock protein 1	Mus musculus	104-109
8836877-6	1996	12-O-Tetradecanoylphorbol-13-acetate (TPA), a protein kinase C (PKC)-activating phorbol ester, inhibited the arsenite-induced accumulation of hsp27.	arsenite	109-117	heat shock protein 1	Mus musculus	142-147
8662954-5	1996	Coimmunoprecipitation experiments provided evidence for the formation of endogenous GADD153-C/EBP-beta complexes in arsenite-treated cells.	arsenite	116-124	DNA-damage inducible transcript 3	Rattus norvegicus	84-91
8662954-5	1996	Coimmunoprecipitation experiments provided evidence for the formation of endogenous GADD153-C/EBP-beta complexes in arsenite-treated cells.	arsenite	116-124	CCAAT/enhancer binding protein beta	Rattus norvegicus	92-102
8662954-8	1996	Here, we demonstrate that extracts prepared from arsenite-treated PC12 cells likewise show increased amounts of factors capable of binding to the GADD153-C/EBP site and that these complexes are comprised at least in part of C/EBP-beta.	arsenite	49-57	DNA-damage inducible transcript 3	Rattus norvegicus	146-153
8662954-8	1996	Here, we demonstrate that extracts prepared from arsenite-treated PC12 cells likewise show increased amounts of factors capable of binding to the GADD153-C/EBP site and that these complexes are comprised at least in part of C/EBP-beta.	arsenite	49-57	CCAAT/enhancer binding protein beta	Rattus norvegicus	224-234
8903404-6	1996	Sodium arsenite (Ars) or hyperthermia (43 degrees C) induced the synthesis of hsp72 messenger RNA (mRNA) and protein in hepatocytes, indicating activation of the HSR.	arsenite	17-20	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	78-83
8798781-10	1996	When incubated with double-stranded RNA, extracts derived from arsenite-treated cells displayed greater degrees of phosphorylation of PKR and eIF-2alpha than did control extracts.	arsenite	63-71	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	134-137
8798781-10	1996	When incubated with double-stranded RNA, extracts derived from arsenite-treated cells displayed greater degrees of phosphorylation of PKR and eIF-2alpha than did control extracts.	arsenite	63-71	eukaryotic translation initiation factor 2A	Homo sapiens	142-152
8798781-12	1996	Induction of either the HSP or GRP chaperones was accompanied by development of translational tolerance to either Ca2+-mobilizing agents or arsenite.	arsenite	140-148	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	24-27
8798781-12	1996	Induction of either the HSP or GRP chaperones was accompanied by development of translational tolerance to either Ca2+-mobilizing agents or arsenite.	arsenite	140-148	gastrin releasing peptide	Homo sapiens	31-34
8798781-14	1996	Conversely, cells possessing induced GRP contents in response to Ca2+-mobilizing agents readily induced the HSPs in response to arsenite.	arsenite	128-136	gastrin releasing peptide	Homo sapiens	37-40
8841493-5	1996	For the spontaneous, 50 microM arsenite- and 100 microM arsenite-enhanced spontaneous mutants in AS52 cells, the percentages of total deletion of the gpt gene are 36.00%, 54.72% and 66.67%, respectively.	arsenite	56-64	alanine aminotransferase 1	Cricetulus griseus	150-153
8884272-1	1996	Arsenite resistance in bacteria is mediated by an efflux pump composed of the arsA and arsB gene products.	arsenite	0-8	arylsulfatase A	Homo sapiens	78-82
8884272-1	1996	Arsenite resistance in bacteria is mediated by an efflux pump composed of the arsA and arsB gene products.	arsenite	0-8	arylsulfatase B	Homo sapiens	87-91
21781682-10	1996	These results indicate that arsenite is an effective modifier of cisplatin-induced resistance and enhanced DNA repair in HeLa/CPR cells.	arsenite	28-36	cytochrome p450 oxidoreductase	Homo sapiens	126-129
8911639-4	1996	Depletion of cell GSH by L-buthionine-SR-sulfoximine, a selective inhibitor of gamma-glutamylcysteine synthetase, enhanced the cytotoxicity of arsenite, arsenate, and MAA, while such depletion suppressed the cytotoxicity of DMAA.	arsenite	143-151	glutamate-cysteine ligase catalytic subunit	Homo sapiens	79-112
8670069-4	1996	GADD153 mRNA induction by both H2O2 and arsenite was potentiated by GSH depletion, and completely inhibited by N-acetyl-cysteine.	arsenite	40-48	DNA damage inducible transcript 3	Homo sapiens	0-7
8769853-2	1996	When C6 cells were exposed to arsenite (50-100 microM for 1 h) or heat (42 degrees C for 30 min), expression of hsp27 and alpha B-crystallin was stimulated, with levels of the two proteins reaching a maximum after 10-16 h of culture.	arsenite	30-38	heat shock protein family B (small) member 1	Rattus norvegicus	112-117
8769853-2	1996	When C6 cells were exposed to arsenite (50-100 microM for 1 h) or heat (42 degrees C for 30 min), expression of hsp27 and alpha B-crystallin was stimulated, with levels of the two proteins reaching a maximum after 10-16 h of culture.	arsenite	30-38	crystallin, alpha B	Rattus norvegicus	122-140
8769853-3	1996	Induction of hsp27 was markedly enhanced when cells were exposed to arsenite in the presence of isoproterenol (20 microM) or epinephrine (20 microM) but not in the presence of phenylephrine.	arsenite	68-76	heat shock protein family B (small) member 1	Rattus norvegicus	13-18
8769853-7	1996	The level of hsp70 in C6 cells, as estimated by western blot analysis, was also enhanced by arsenite or heat stress.	arsenite	92-100	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	13-18
8769853-9	1996	By contrast, induction of alpha B-crystallin by heat or arsenite stress was suppressed when isoproterenol, cholera toxin, forskolin, or dibutyryl cyclic AMP was present during the stress period.	arsenite	56-64	crystallin, alpha B	Rattus norvegicus	26-44
8634298-6	1996	An unusually large, reticulocyte-specific enzyme, known as E2-230K, is unique among the large family of E2 enzymes is being susceptible to inhibition by inorganic arsenite [Klemperer et al.	arsenite	163-171	ubiquitin conjugating enzyme E2 O	Homo sapiens	59-66
8550532-1	1996	The single cysteine in the ArsB protein subunit of the arsenite resistance pump was changed to serine and alanine residues.	arsenite	55-63	arylsulfatase B	Homo sapiens	27-31
8556713-0	1996	Arsenite, but not cadmium, induces ornithine decarboxylase and heme oxygenase activity in rat liver: relevance to arsenic carcinogenesis.	arsenite	0-8	ornithine decarboxylase 1	Rattus norvegicus	35-58
8670069-7	1996	However, GADD153 induction by arsenite was only modestly reduced in the same cells, suggesting a lesser contribution of peroxides to gene activation by arsenite.	arsenite	30-38	DNA damage inducible transcript 3	Homo sapiens	9-16
23888893-9	1996	Elevated levels of metallothionein and haem oxygenase (HO) were indicated in Western blots after treatment with cadmium or arsenite (only HO).	arsenite	123-131	metallothionein	Salmo salar	19-34
8902523-0	1996	Differential activation of ERK, JNK/SAPK and P38/CSBP/RK map kinase family members during the cellular response to arsenite.	arsenite	115-123	Eph receptor B1	Rattus norvegicus	27-30
8902523-0	1996	Differential activation of ERK, JNK/SAPK and P38/CSBP/RK map kinase family members during the cellular response to arsenite.	arsenite	115-123	mitogen-activated protein kinase 8	Rattus norvegicus	32-40
8902523-0	1996	Differential activation of ERK, JNK/SAPK and P38/CSBP/RK map kinase family members during the cellular response to arsenite.	arsenite	115-123	mitogen activated protein kinase 14	Rattus norvegicus	45-48
8905098-10	1996	The arsenic resistance efflux system transports arsenite, using alternatively either a two-component (ArsA and ArsB) ATPase or a single polypeptide (ArsB) functioning as a chemiosmotic transporter.	arsenite	48-56	arylsulfatase A	Homo sapiens	102-106
8905098-10	1996	The arsenic resistance efflux system transports arsenite, using alternatively either a two-component (ArsA and ArsB) ATPase or a single polypeptide (ArsB) functioning as a chemiosmotic transporter.	arsenite	48-56	arylsulfatase B	Homo sapiens	111-115
8905098-10	1996	The arsenic resistance efflux system transports arsenite, using alternatively either a two-component (ArsA and ArsB) ATPase or a single polypeptide (ArsB) functioning as a chemiosmotic transporter.	arsenite	48-56	arylsulfatase B	Homo sapiens	149-153
8905098-11	1996	The third gene in the arsenic resistance system, arsC, encodes an enzyme that converts intracellular arsenate [As (V)] to arsenite [As (III)], the substrate of the efflux system.	arsenite	122-130	steroid sulfatase	Homo sapiens	49-53
8902524-8	1996	The antioxidants, N-acetylcysteine or dimethylfumaric acid, increased intracellular thiol status and prevented both oxidant formation and translocation of NF-kappa B binding proteins in response to arsenite.	arsenite	198-206	nuclear factor kappa B subunit 1	Homo sapiens	155-165
8902523-0	1996	Differential activation of ERK, JNK/SAPK and P38/CSBP/RK map kinase family members during the cellular response to arsenite.	arsenite	115-123	mitogen activated protein kinase 14	Rattus norvegicus	49-53
8902523-4	1996	Arsenite treatment potently activated both JNK/SAPK and p38, but only moderately activated ERK.	arsenite	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	43-46
8902523-4	1996	Arsenite treatment potently activated both JNK/SAPK and p38, but only moderately activated ERK.	arsenite	0-8	mitogen-activated protein kinase 9	Rattus norvegicus	47-51
8902523-4	1996	Arsenite treatment potently activated both JNK/SAPK and p38, but only moderately activated ERK.	arsenite	0-8	mitogen activated protein kinase 14	Rattus norvegicus	56-59
8902523-6	1996	Suramin, a growth factor receptor poison, significantly inhibited ERK activation by arsenite, but had little effect on either JNK/SAPK or p38 activity.	arsenite	84-92	Eph receptor B1	Rattus norvegicus	66-69
8902523-8	1996	In addition, comparative studies with wild-type PC12 cells and PC12 cells expressing a dominant negative Ras mutant allele indicated that arsenite activates ERK primarily through a Ras-dependent pathway(s), while activation of both JNK/SAPK and p38 occurs through a mechanism relatively independent of Ras.	arsenite	138-146	Eph receptor B1	Rattus norvegicus	157-160
8902523-8	1996	In addition, comparative studies with wild-type PC12 cells and PC12 cells expressing a dominant negative Ras mutant allele indicated that arsenite activates ERK primarily through a Ras-dependent pathway(s), while activation of both JNK/SAPK and p38 occurs through a mechanism relatively independent of Ras.	arsenite	138-146	mitogen activated protein kinase 14	Rattus norvegicus	245-248
8902524-7	1996	Supershift analysis demonstrated that p65/p50 heterodimers accounted for the majority of proteins binding consensus kappa B sequences in cells treated with arsenite or oxidants.	arsenite	156-164	RELA proto-oncogene, NF-kB subunit	Homo sapiens	38-41
8902524-7	1996	Supershift analysis demonstrated that p65/p50 heterodimers accounted for the majority of proteins binding consensus kappa B sequences in cells treated with arsenite or oxidants.	arsenite	156-164	nuclear factor kappa B subunit 1	Homo sapiens	42-45
7644478-5	1995	We also show that MRP increases the export of glutathione from the cell and this increased export is further elevated in the presence of arsenite.	arsenite	137-145	ATP binding cassette subfamily C member 3	Homo sapiens	18-21
8900573-6	1995	Arsenate (AsV) is converted to arsenite by a soluble reductase (ArsC).	arsenite	31-39	steroid sulfatase	Homo sapiens	64-68
8690728-1	1995	The expression of alphaB crystallin, hsp27, and hsp70 in C6 cells increased when they were exposed to arsenite (50 microM for 1 h) or heat (42 degrees C for 30 min), as detected by specific immunoassays, Western blot analysis, and Northern blot analysis.	arsenite	102-110	heat shock protein family B (small) member 1	Homo sapiens	37-42
8690728-1	1995	The expression of alphaB crystallin, hsp27, and hsp70 in C6 cells increased when they were exposed to arsenite (50 microM for 1 h) or heat (42 degrees C for 30 min), as detected by specific immunoassays, Western blot analysis, and Northern blot analysis.	arsenite	102-110	heat shock protein family A (Hsp70) member 4	Homo sapiens	48-53
8690728-6	1995	The arsenite-induced release of arachidonic acid from cells was also stimulated in the presence of PMA and/or akadaic acid, and the stimulatory effects of PMA and okadaic acid on the arsenite-induced accumulation of alphaB crystallin and hsp27 were strongly suppressed by quinacrine, an inhibitor of phospholipase A2.	arsenite	4-12	heat shock protein family B (small) member 1	Homo sapiens	238-243
8690728-6	1995	The arsenite-induced release of arachidonic acid from cells was also stimulated in the presence of PMA and/or akadaic acid, and the stimulatory effects of PMA and okadaic acid on the arsenite-induced accumulation of alphaB crystallin and hsp27 were strongly suppressed by quinacrine, an inhibitor of phospholipase A2.	arsenite	4-12	phospholipase A2 group IB	Homo sapiens	300-316
8690728-6	1995	The arsenite-induced release of arachidonic acid from cells was also stimulated in the presence of PMA and/or akadaic acid, and the stimulatory effects of PMA and okadaic acid on the arsenite-induced accumulation of alphaB crystallin and hsp27 were strongly suppressed by quinacrine, an inhibitor of phospholipase A2.	arsenite	183-191	heat shock protein family B (small) member 1	Homo sapiens	238-243
8690728-6	1995	The arsenite-induced release of arachidonic acid from cells was also stimulated in the presence of PMA and/or akadaic acid, and the stimulatory effects of PMA and okadaic acid on the arsenite-induced accumulation of alphaB crystallin and hsp27 were strongly suppressed by quinacrine, an inhibitor of phospholipase A2.	arsenite	183-191	phospholipase A2 group IB	Homo sapiens	300-316
7891750-2	1994	The first P-glycoprotein related gene described in Leishmania was ltpgpA, a gene frequently amplified in arsenite resistant Leishmania.	arsenite	105-113	ATP binding cassette subfamily B member 1	Homo sapiens	10-24
7626663-0	1995	Consequences of the overexpression of ubiquitin in yeast: elevated tolerances of osmostress, ethanol and canavanine, yet reduced tolerances of cadmium, arsenite and paromomycin.	arsenite	152-160	ubiquitin	Saccharomyces cerevisiae S288C	38-47
8537304-3	1995	When cells were exposed to arsenite or heat in the presence of mastoparan, a peptide toxin from wasp venom, the induction of hsp27 and alpha B crystallin was markedly stimulated, as detected by means of specific immunoassays, Western blot analysis, and Northern blot analysis.	arsenite	27-35	heat shock protein family B (small) member 1	Rattus norvegicus	125-130
8537304-3	1995	When cells were exposed to arsenite or heat in the presence of mastoparan, a peptide toxin from wasp venom, the induction of hsp27 and alpha B crystallin was markedly stimulated, as detected by means of specific immunoassays, Western blot analysis, and Northern blot analysis.	arsenite	27-35	crystallin, alpha B	Rattus norvegicus	135-153
7883968-3	1995	The DDP-resistant variant 2008/A was also cross-resistant to arsenite but not to stibogluconate, which contains pentavalent antimony.	arsenite	61-69	translocase of inner mitochondrial membrane 8A	Homo sapiens	4-7
7621791-6	1995	Arsenate (As(V)) can react with glutathione in buffered aqueous solutions to produce arsenite (As(III)) and oxidized glutathione.	arsenite	85-93	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	10-15
7744758-1	1995	The ArsA protein, the catalytic subunit of the oxyanion-translocating ATPase responsible for resistance to arsenicals and antimonials in Escherichia coli, is activated by arsenite or antimonite.	arsenite	171-179	arylsulfatase A	Mus musculus	4-8
7747278-1	1995	The present study is aimed at determining whether the induction of heat-shock protein (hsp) synthesis, heat-shock mRNAs, and tolerance development after arsenite application has been sensitized to low concentrations of arsenite in Reuber H35 rat hepatoma cells.	arsenite	219-227	selenoprotein K	Rattus norvegicus	67-85
7747278-1	1995	The present study is aimed at determining whether the induction of heat-shock protein (hsp) synthesis, heat-shock mRNAs, and tolerance development after arsenite application has been sensitized to low concentrations of arsenite in Reuber H35 rat hepatoma cells.	arsenite	219-227	selenoprotein K	Rattus norvegicus	87-90
7747278-4	1995	It was observed that under conditions of enhanced sensitivity, an additional increase occurred in hsp synthesis as well as in hsp mRNA (as exemplified by hsp68 mRNA behavior) when low concentrations of arsenite were applied to arsenite pretreated cells.	arsenite	202-210	selenoprotein K	Rattus norvegicus	98-101
7747278-4	1995	It was observed that under conditions of enhanced sensitivity, an additional increase occurred in hsp synthesis as well as in hsp mRNA (as exemplified by hsp68 mRNA behavior) when low concentrations of arsenite were applied to arsenite pretreated cells.	arsenite	202-210	selenoprotein K	Rattus norvegicus	126-129
7747278-4	1995	It was observed that under conditions of enhanced sensitivity, an additional increase occurred in hsp synthesis as well as in hsp mRNA (as exemplified by hsp68 mRNA behavior) when low concentrations of arsenite were applied to arsenite pretreated cells.	arsenite	227-235	selenoprotein K	Rattus norvegicus	126-129
7629056-4	1995	The ArsC protein is an arsenate reductase that reduces arsenate to arsenite, which is subsequently pumped out of the cell.	arsenite	67-75	steroid sulfatase	Homo sapiens	4-8
7999084-0	1994	Metallothionein-II and ferritin H mRNA levels are increased in arsenite-exposed HeLa cells.	arsenite	63-71	metallothionein 2A	Homo sapiens	0-18
7999084-4	1994	Isolation and sequencing of three clones that showed a higher hybridization signal to RNA from arsenite-exposed cells, versus unexposed cells, revealed that two of the cDNAs coded for human ferritin H chain and the other coded for metallothionein-II.	arsenite	95-103	metallothionein 2A	Homo sapiens	231-249
7954421-7	1994	The MRP-transfected cells were also resistant to some heavy metal anions including arsenite, arsenate, and trivalent and pentavalent antimonials but were not resistant to cadmium chloride.	arsenite	83-91	ATP binding cassette subfamily C member 1	Homo sapiens	4-7
7858064-5	1994	Treatment of FS-4 cells with sodium arsenite led to a very strong increase in the phosphorylation of Hsp28 demonstrable after 5 min and persisting for at least 4 h. Tyrosine phosphorylation of pp42 and pp44 MAP kinases was increased by TNF treatment, whereas arsenite produced a modest increase in tyrosine phosphorylation of pp44 while decreasing that of pp42 MAP kinase.	arsenite	36-44	heat shock protein family B (small) member 1	Homo sapiens	101-106
7858064-5	1994	Treatment of FS-4 cells with sodium arsenite led to a very strong increase in the phosphorylation of Hsp28 demonstrable after 5 min and persisting for at least 4 h. Tyrosine phosphorylation of pp42 and pp44 MAP kinases was increased by TNF treatment, whereas arsenite produced a modest increase in tyrosine phosphorylation of pp44 while decreasing that of pp42 MAP kinase.	arsenite	36-44	tumor necrosis factor	Homo sapiens	236-239
7934966-7	1994	Moreover, catalase could effectively reduce the frequency of arsenite-induced micronuclei.	arsenite	61-69	catalase	Cricetulus griseus	10-18
8048913-3	1994	According to its substrate- and inhibitor-specificity, this arsenite-induced proteolytic activity was very similar to lysosomal cathepsin B.	arsenite	60-68	cathepsin B	Cricetulus griseus	128-139
8003493-2	1994	The purified enzyme reduced radioactive arsenate to arsenite when coupled to thioredoxin, thioredoxin reductase, and NADPH.	arsenite	52-60	AT695_RS07555	Staphylococcus aureus	77-88
8003493-2	1994	The purified enzyme reduced radioactive arsenate to arsenite when coupled to thioredoxin, thioredoxin reductase, and NADPH.	arsenite	52-60	AT695_RS13830	Staphylococcus aureus	90-111
7934966-8	1994	These results indicate that the low catalase activity may be an important reason why XRS-5 cells are more sensitive to the toxic effects of arsenite, and arsenite probably induces micronuclei via the overproduction of H2O2.	arsenite	140-148	catalase	Cricetulus griseus	36-44
8016744-6	1994	Maximal levels of HSP 72 were observed 24 hours after AS exposure and 10 hours after SAL exposure.	arsenite	54-56	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	18-24
8097705-8	1993	Arsenite also increased glutathione S-transferase [EC 2.5.1.18] activity in rat kidney.	arsenite	0-8	hematopoietic prostaglandin D synthase	Rattus norvegicus	24-49
8501052-4	1993	Active efflux from cells loaded with arsenite required the presence of the plasmid-determined arsB gene.	arsenite	37-45	arsenic efflux pump protein	Staphylococcus aureus	94-98
8501052-9	1993	Cloning of the E. coli plasmid R773 arsA gene (the determinant of the arsenite-dependent ATPase) in trans to the S. aureus gene arsB resulted in increased resistance to arsenite.	arsenite	70-78	arsenic efflux pump protein	Staphylococcus aureus	128-132
8482719-4	1993	It is shown that the concentrations of arsenite that enhance the mitogenic effect of serum also increase the mRNA levels of c-fos, HSP68, and HSP84 and induce the specific synthesis of Heat Shock Proteins (HSPs).	arsenite	39-47	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	124-129
8482719-4	1993	It is shown that the concentrations of arsenite that enhance the mitogenic effect of serum also increase the mRNA levels of c-fos, HSP68, and HSP84 and induce the specific synthesis of Heat Shock Proteins (HSPs).	arsenite	39-47	heat shock protein 90 alpha family class B member 1	Homo sapiens	142-147
8466913-0	1993	Differential effects of the reversible thiol-reactive agents arsenite and methyl methanethiosulfonate on steroid binding by the glucocorticoid receptor.	arsenite	61-69	nuclear receptor subfamily 3 group C member 1	Homo sapiens	128-151
8466913-1	1993	The hormone binding domain of the glucocorticoid receptor contains a unique vicinally spaced dithiol, and when it is bound by arsenite under conditions that are specific for reaction with vicinally spaced dithiols versus monothiols, steroid binding activity is eliminated [Simons, S. S., Jr., Chakraborti, P. K., & Cavanaugh, A. H. (1990) J. Biol.	arsenite	126-134	nuclear receptor subfamily 3 group C member 1	Homo sapiens	34-57
8267588-3	1993	Stressors, including heat shock, arsenite and cadmium can induce c-fos transcription, but a heat shock element in the c-fos promoter has not been described.	arsenite	33-41	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-70
8267588-4	1993	In this report we show that the induction of c-fos by heat shock, arsenite and cadmium can be mediated by the serum response element.	arsenite	66-74	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	45-50
8267588-5	1993	Furthermore we show that casein kinase II, which has been proposed to be involved in serum induction via the serum response element, may also be involved in heat shock, arsenite and cadmium induction of c-fos.	arsenite	169-177	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	203-208
8433029-3	1993	HSP72 was constitutively expressed in HeLa S3 cells and elevated upon heat or arsenite stress.	arsenite	78-86	heat shock protein family A (Hsp70) member 1A	Homo sapiens	0-5
8113214-0	1993	Coinduction of two low-molecular-weight stress proteins, alpha B crystallin and HSP28, by heat or arsenite stress in human glioma cells.	arsenite	98-106	heat shock protein family B (small) member 1	Homo sapiens	80-85
8113214-6	1993	Expression of alpha B crystallin and HSP28 mRNAs in cells was enhanced after heat stress and after exposure to arsenite.	arsenite	111-119	heat shock protein family B (small) member 1	Homo sapiens	37-42
8433029-5	1993	However, at the time of maximal thermotolerance, elevated levels of HSP72 were found associated with nuclei isolated from both heat- and arsenite-induced thermotolerant cells.	arsenite	137-145	heat shock protein family A (Hsp70) member 1A	Homo sapiens	68-73
1456954-4	1992	The role of flavin in the nitroreductase activity was supported by (a) the nitrofuran effect on the spectral properties of anaerobic, arsenite-inhibited, NADH-reduced LipDH; (b) FAD catalytic activity in a NADH-nitrofuran model system; and (c) the nitroreductase activity of LipDH monomer.	arsenite	134-142	dihydrolipoamide dehydrogenase	Homo sapiens	167-172
1331097-4	1992	Azurin and a c-type cytochrome, both isolated from A. faecalis, each serves as an electron acceptor to arsenite oxidase and may form a periplasmic electron transfer pathway for arsenite detoxification.	arsenite	103-111	azurin	Alcaligenes faecalis	0-6
1417983-7	1992	Moreover, the induction of heme oxygenase and p67 syntheses by the thiol-reactive agents arsenite and diethylmaleate was also inhibited by GSH treatment and enhanced by BSO treatment.	arsenite	89-97	CD33 molecule	Homo sapiens	46-49
1409657-0	1992	Reduction of arsenate to arsenite by the ArsC protein of the arsenic resistance operon of Staphylococcus aureus plasmid pI258.	arsenite	25-33	arsenate reductase	Staphylococcus aureus	41-45
1409657-2	1992	ArsC has now been shown to be an arsenate reductase, converting intracellular arsenate [As(V)] to arsenite [As(III)], which is then exported from the cells by an energy-dependent efflux process.	arsenite	98-106	arsenate reductase	Staphylococcus aureus	0-4
1409657-4	1992	Purified ArsC protein coupled in vitro with thioredoxin plus dithiothreitol (but not 2-mercaptoethanol or reduced glutathione) to reduce arsenate to arsenite.	arsenite	149-157	arsenate reductase	Staphylococcus aureus	9-13
1644825-18	1992	As expected from prior results with arsenite, p-aminophenylarsenoxide was also a potent inhibitor of the turnover of ubiquitin-(human) alpha-lactalbumin conjugates.	arsenite	36-44	lactalbumin alpha	Homo sapiens	135-152
8264344-6	1993	In PBL 4-OOH-IF also induced rapid phosphorylation of the small heat shock protein (HSP27) signaling a similar type of stress response as reported for several other agents (e.g. arsenite, phorbol ester, tumor necrosis factor).	arsenite	178-186	heat shock protein family B (small) member 1	Homo sapiens	84-89
1748722-5	1991	In these circumstances, as with arsenite, stimulation is reversible, with t1/2 of 1-2 hours; stimulation is compatible with a translocation of the glucose transporter protein between an intracellular site and the plasma membrane (shown here for serum and previously for arsenite).	arsenite	32-40	interleukin 1 receptor like 1	Homo sapiens	74-85
1581359-8	1992	This suggests that stress-treatment of cells enhanced SAT activity posttranslationally and that some factor(s) which was synthesized de novo during the treatment of arsenite is involved in the stabilization of the enzyme.	arsenite	165-173	spermidine/spermine N1-acetyl transferase 1	Mus musculus	54-57
1413874-2	1992	Injection of arsenite (As3+) to control rats results in losses of total hepatic cytochrome P-450 and significant decreases of ethoxycoumarin O-deethylase (ECOD) and ethoxyresorufin O-deethylase (EROD) activities.	arsenite	13-21	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	80-96
1534328-12	1992	An internal deletion mutation in arsB resulted in decreased resistance to arsenate and total loss of arsenite and antimonite resistances.	arsenite	101-109	arsenic efflux pump protein	Staphylococcus aureus	33-37
1534328-13	1992	Partial deletion of 56 bp from the 3" end of the arsC gene resulted in loss of resistance to arsenate; the determinant retained arsenite and antimonite resistances.	arsenite	128-136	arsenate reductase	Staphylococcus aureus	49-53
1349537-0	1992	Quercetin, a bioflavonoid, inhibits the increase of human multidrug resistance gene (MDR1) expression caused by arsenite.	arsenite	112-120	ATP binding cassette subfamily B member 1	Homo sapiens	85-89
1349537-4	1992	The increase of P-glycoprotein synthesis and MDR1 mRNA accumulation caused by exposure to arsenite were inhibited by quercetin.	arsenite	90-98	ATP binding cassette subfamily B member 1	Homo sapiens	16-30
1349537-4	1992	The increase of P-glycoprotein synthesis and MDR1 mRNA accumulation caused by exposure to arsenite were inhibited by quercetin.	arsenite	90-98	ATP binding cassette subfamily B member 1	Homo sapiens	45-49
1349537-5	1992	The CAT assay suggested that quercetin suppressed the transcriptional activation of the MDR1 gene after exposure to arsenite.	arsenite	116-124	ATP binding cassette subfamily B member 1	Homo sapiens	88-92
1360409-3	1992	Deletion analysis of the MDR1 promoter indicated that the transcriptional activation after exposure to arsenite depends on a 60-bp region containing two heat-shock responsive elements.	arsenite	103-111	ATP binding cassette subfamily B member 1	Homo sapiens	25-29
1370842-3	1992	Inhibition of overall protein and heat shock protein (HSP) synthesis (greater than 95%) by cycloheximide (25 micrograms/ml) during tolerance development nearly completely abolished thermotolerance induced by arsenite, while significant levels of heat-induced thermotolerance were still apparent.	arsenite	208-216	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	54-57
1730670-3	1992	Heat shock of HeLa cell cultures, or treatment with arsenite, phorbol ester, or tumor necrosis factor, caused a rapid phosphorylation of preexisting HSP27 and the appearance of three phosphorylated isoforms, HSP27 B, C, and D. Digestion with trypsin and fractionation of the peptides by reverse phase high performance liquid chromatography revealed three 32P-labeled phosphopeptides.	arsenite	52-60	heat shock protein family B (small) member 1	Homo sapiens	149-154
1730670-3	1992	Heat shock of HeLa cell cultures, or treatment with arsenite, phorbol ester, or tumor necrosis factor, caused a rapid phosphorylation of preexisting HSP27 and the appearance of three phosphorylated isoforms, HSP27 B, C, and D. Digestion with trypsin and fractionation of the peptides by reverse phase high performance liquid chromatography revealed three 32P-labeled phosphopeptides.	arsenite	52-60	heat shock protein family B (small) member 1	Homo sapiens	208-213
1747062-6	1991	Thus, we suggested that ubiquitin is possibly involved in the action of arsenite in potentiating UV-induced cell killing.	arsenite	72-80	ubiquitin	Cricetulus griseus	24-33
1867634-4	1991	Using two-dimensional polyacrylamide gel electrophoresis, p31 induced by PGJ2 had an isoelectric point of 5.4, which overlapped exactly with that induced by by arsenite.	arsenite	160-168	ATPase H+ transporting V1 subunit E1	Rattus norvegicus	58-61
1824941-1	1991	The ArsA protein, the catalytic component of the plasmid-encoded resistance system for removal of the toxic oxyanions arsenite, antimonite, and arsenate from bacterial cells, catalyzes oxyanion-stimulated ATP hydrolysis.	arsenite	118-126	arylsulfatase A	Homo sapiens	4-8
2170528-5	1990	We find that after induction of the cellular heat shock response by either heat or arsenite treatment, both spontaneously TNF-sensitive cells and those cells made sensitive by inhibition of protein synthesis are nearly completely protected from TNF cytolysis.	arsenite	83-91	tumor necrosis factor	Mus musculus	122-125
2170528-5	1990	We find that after induction of the cellular heat shock response by either heat or arsenite treatment, both spontaneously TNF-sensitive cells and those cells made sensitive by inhibition of protein synthesis are nearly completely protected from TNF cytolysis.	arsenite	83-91	tumor necrosis factor	Mus musculus	245-248
25199681-5	2015	Our results showed that H-Ras(G12V)-transformed human urothelial cells (HUC-RAS) were more susceptible to arsenite-induced cell death, DNA damage, micronuclei formation and anchorage-independent growth than control cells (HUC-neo).	arsenite	106-114	HRas proto-oncogene, GTPase	Homo sapiens	24-29
33939924-8	2021	We validated four Caprin-1 interactors that localized to arsenite-induced SGs: ANKHD1, TALIN-1, GEMIN5, and SNRNP200.	arsenite	57-65	cell cycle associated protein 1	Homo sapiens	18-26
33939924-8	2021	We validated four Caprin-1 interactors that localized to arsenite-induced SGs: ANKHD1, TALIN-1, GEMIN5, and SNRNP200.	arsenite	57-65	ankyrin repeat and KH domain containing 1	Homo sapiens	79-85
33939924-8	2021	We validated four Caprin-1 interactors that localized to arsenite-induced SGs: ANKHD1, TALIN-1, GEMIN5, and SNRNP200.	arsenite	57-65	talin 1	Homo sapiens	87-94
33939924-8	2021	We validated four Caprin-1 interactors that localized to arsenite-induced SGs: ANKHD1, TALIN-1, GEMIN5, and SNRNP200.	arsenite	57-65	gem nuclear organelle associated protein 5	Homo sapiens	96-102
33939924-8	2021	We validated four Caprin-1 interactors that localized to arsenite-induced SGs: ANKHD1, TALIN-1, GEMIN5, and SNRNP200.	arsenite	57-65	small nuclear ribonucleoprotein U5 subunit 200	Homo sapiens	108-116
32890875-4	2021	We found that HER2 was up-regulated in human uroepithelial cells treated with arsenite as well as in the bladder tissues of DMAV-exposed rats.	arsenite	78-86	erb-b2 receptor tyrosine kinase 2	Homo sapiens	14-18
32890875-7	2021	Furthermore, inhibition of HER2, as well as that of the MAPK, AKT and STAT3 pathways, attenuated arsenite-induced proliferation, migration and angiogenesis of human uroepithelial cells, and increased apoptosis rates in vitro.	arsenite	97-105	erb-b2 receptor tyrosine kinase 2	Homo sapiens	27-31
32890875-7	2021	Furthermore, inhibition of HER2, as well as that of the MAPK, AKT and STAT3 pathways, attenuated arsenite-induced proliferation, migration and angiogenesis of human uroepithelial cells, and increased apoptosis rates in vitro.	arsenite	97-105	AKT serine/threonine kinase 1	Homo sapiens	62-65
32890875-7	2021	Furthermore, inhibition of HER2, as well as that of the MAPK, AKT and STAT3 pathways, attenuated arsenite-induced proliferation, migration and angiogenesis of human uroepithelial cells, and increased apoptosis rates in vitro.	arsenite	97-105	signal transducer and activator of transcription 3	Homo sapiens	70-75
33814512-0	2021	Arsenite induces tissue factor synthesis through Nrf2 activation in cultured human aortic smooth muscle cells.	arsenite	0-8	coagulation factor III, tissue factor	Homo sapiens	17-30
33814512-0	2021	Arsenite induces tissue factor synthesis through Nrf2 activation in cultured human aortic smooth muscle cells.	arsenite	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	49-53
33814512-4	2021	In the present study, we investigated the effect of arsenite on the expression of TF in human aortic smooth muscle cells (HASMCs) and the underlying molecular mechanisms.	arsenite	52-60	coagulation factor III, tissue factor	Homo sapiens	82-84
33814512-5	2021	We found that (1) arsenite stimulated TF synthesis and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in HASMCs, (2) sulforaphane, an Nrf2 activator, also stimulated TF synthesis in HASMCs, and (3) arsenite-induced upregulation of TF synthesis was prevented by Nrf2 knockdown in HASMCs.	arsenite	18-26	coagulation factor III, tissue factor	Homo sapiens	38-40
33814512-5	2021	We found that (1) arsenite stimulated TF synthesis and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in HASMCs, (2) sulforaphane, an Nrf2 activator, also stimulated TF synthesis in HASMCs, and (3) arsenite-induced upregulation of TF synthesis was prevented by Nrf2 knockdown in HASMCs.	arsenite	18-26	NFE2 like bZIP transcription factor 2	Homo sapiens	69-112
33814512-5	2021	We found that (1) arsenite stimulated TF synthesis and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in HASMCs, (2) sulforaphane, an Nrf2 activator, also stimulated TF synthesis in HASMCs, and (3) arsenite-induced upregulation of TF synthesis was prevented by Nrf2 knockdown in HASMCs.	arsenite	18-26	NFE2 like bZIP transcription factor 2	Homo sapiens	114-118
33814512-5	2021	We found that (1) arsenite stimulated TF synthesis and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in HASMCs, (2) sulforaphane, an Nrf2 activator, also stimulated TF synthesis in HASMCs, and (3) arsenite-induced upregulation of TF synthesis was prevented by Nrf2 knockdown in HASMCs.	arsenite	18-26	NFE2 like bZIP transcription factor 2	Homo sapiens	160-164
33814512-5	2021	We found that (1) arsenite stimulated TF synthesis and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in HASMCs, (2) sulforaphane, an Nrf2 activator, also stimulated TF synthesis in HASMCs, and (3) arsenite-induced upregulation of TF synthesis was prevented by Nrf2 knockdown in HASMCs.	arsenite	18-26	coagulation factor III, tissue factor	Homo sapiens	192-194
33814512-5	2021	We found that (1) arsenite stimulated TF synthesis and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in HASMCs, (2) sulforaphane, an Nrf2 activator, also stimulated TF synthesis in HASMCs, and (3) arsenite-induced upregulation of TF synthesis was prevented by Nrf2 knockdown in HASMCs.	arsenite	18-26	coagulation factor III, tissue factor	Homo sapiens	192-194
33814512-5	2021	We found that (1) arsenite stimulated TF synthesis and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in HASMCs, (2) sulforaphane, an Nrf2 activator, also stimulated TF synthesis in HASMCs, and (3) arsenite-induced upregulation of TF synthesis was prevented by Nrf2 knockdown in HASMCs.	arsenite	18-26	NFE2 like bZIP transcription factor 2	Homo sapiens	160-164
33814512-6	2021	These results suggest that arsenite promotes TF synthesis by activating the Nrf2 pathway in HASMCs and that the induction of TF expression by arsenite may be related to the progression of atherosclerosis.	arsenite	27-35	coagulation factor III, tissue factor	Homo sapiens	45-47
33814512-6	2021	These results suggest that arsenite promotes TF synthesis by activating the Nrf2 pathway in HASMCs and that the induction of TF expression by arsenite may be related to the progression of atherosclerosis.	arsenite	27-35	NFE2 like bZIP transcription factor 2	Homo sapiens	76-80
33814512-6	2021	These results suggest that arsenite promotes TF synthesis by activating the Nrf2 pathway in HASMCs and that the induction of TF expression by arsenite may be related to the progression of atherosclerosis.	arsenite	142-150	coagulation factor III, tissue factor	Homo sapiens	125-127
1703776-3	1990	In previous studies, expression of the human MDR1 gene has been shown to be regulated by heat shock, arsenite, and cadmium in a kidney carcinoma cell line, and mdr RNA is dramatically elevated in rat liver after partial hepatectomy or treatment of the animals with cytotoxic agents.	arsenite	101-109	ATP binding cassette subfamily B member 1	Homo sapiens	45-49
2298732-0	1990	Arsenite and cadmium(II) as probes of glucocorticoid receptor structure and function.	arsenite	0-8	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	38-61
2298732-2	1990	Inhibition by arsenite was faster and occurred at lower concentrations than for Cd2+.	arsenite	14-22	Cd2 molecule	Rattus norvegicus	80-83
2105965-8	1990	Chemical inducers of thermotolerance (arsenite and diamide) increased GalNAcT activity, but the increase was modest when compared to that following hyperthermia.	arsenite	38-46	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	70-77
2302229-2	1990	The p40 was induced not only by heat shock but by arsenite and 2-azetidine carboxylic acid.	arsenite	50-58	interleukin 9	Homo sapiens	4-7
1967174-0	1990	Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells.	arsenite	15-23	ATP binding cassette subfamily B member 1	Homo sapiens	73-77
7843081-6	1994	The arsenic-resistance system of gram-negative bacteria functions as an oxyanion efflux ATPase for arsenite and presumably antimonite.	arsenite	99-107	dynein axonemal heavy chain 8	Homo sapiens	88-94
25493608-8	2015	Real-time RT-PCR confirmed a major, significant arsenite-induced stabilization of the mRNA encoding delta aminolevulinate synthase 1 (ALAS1), the rate-limiting enzyme in heme biosynthesis.	arsenite	48-56	5'-aminolevulinate synthase 1	Homo sapiens	100-132
25493608-8	2015	Real-time RT-PCR confirmed a major, significant arsenite-induced stabilization of the mRNA encoding delta aminolevulinate synthase 1 (ALAS1), the rate-limiting enzyme in heme biosynthesis.	arsenite	48-56	5'-aminolevulinate synthase 1	Homo sapiens	134-139
25493608-9	2015	This change presumably accounted for at least part of the 2.7-fold increase in steady-state ALAS1 mRNA levels seen after arsenite treatment.	arsenite	121-129	5'-aminolevulinate synthase 1	Homo sapiens	92-97
25493608-10	2015	This could reflect decreases in cellular heme caused by the massive induction by arsenite of heme oxygenase mRNA (HMOX1; 68-fold increase), the rate-limiting enzyme in heme catabolism.	arsenite	81-89	heme oxygenase 1	Homo sapiens	114-119
7843081-8	1994	The absence of the arsA gene (for the ATPase subunit) in gram-positive bacteria raises questions of energy-coupling for arsenite efflux.	arsenite	120-128	arylsulfatase A	Homo sapiens	19-23
7843081-8	1994	The absence of the arsA gene (for the ATPase subunit) in gram-positive bacteria raises questions of energy-coupling for arsenite efflux.	arsenite	120-128	dynein axonemal heavy chain 8	Homo sapiens	38-44
34861471-10	2022	p38 inhibition markedly increased arsenite-induced Nix protein and reduced p62 protein levels, resulting in increased autophagy and apoptosis.	arsenite	34-42	mitogen-activated protein kinase 14	Homo sapiens	0-3
34968464-3	2022	The aim of this work was to evaluate leptin and adiponectin in mature 3T3-L1 adipocytes exposed to palmitate (simulating excess fat intake), arsenite, or both throughout two different stages of adipogenesis.	arsenite	141-149	leptin	Homo sapiens	37-43
34968464-3	2022	The aim of this work was to evaluate leptin and adiponectin in mature 3T3-L1 adipocytes exposed to palmitate (simulating excess fat intake), arsenite, or both throughout two different stages of adipogenesis.	arsenite	141-149	adiponectin, C1Q and collagen domain containing	Homo sapiens	48-59
34968464-5	2022	KEY FINDINGS: Leptin and adiponectin secretion decreased by arsenite alone or in combination with palmitate due to reduced gene and protein expression of both adipokines.	arsenite	60-68	leptin	Homo sapiens	14-20
34968464-5	2022	KEY FINDINGS: Leptin and adiponectin secretion decreased by arsenite alone or in combination with palmitate due to reduced gene and protein expression of both adipokines.	arsenite	60-68	adiponectin, C1Q and collagen domain containing	Homo sapiens	25-36
34861471-0	2022	Arsenite-induced cytotoxicity is regulated by p38-SQSTM1/p62 and JNK-BNIP3L/Nix signaling in lung cancer cells.	arsenite	0-8	mitogen-activated protein kinase 14	Homo sapiens	46-49
34861471-0	2022	Arsenite-induced cytotoxicity is regulated by p38-SQSTM1/p62 and JNK-BNIP3L/Nix signaling in lung cancer cells.	arsenite	0-8	sequestosome 1	Homo sapiens	50-56
34861471-0	2022	Arsenite-induced cytotoxicity is regulated by p38-SQSTM1/p62 and JNK-BNIP3L/Nix signaling in lung cancer cells.	arsenite	0-8	sequestosome 1	Homo sapiens	57-60
34861471-0	2022	Arsenite-induced cytotoxicity is regulated by p38-SQSTM1/p62 and JNK-BNIP3L/Nix signaling in lung cancer cells.	arsenite	0-8	mitogen-activated protein kinase 8	Homo sapiens	65-68
34861471-0	2022	Arsenite-induced cytotoxicity is regulated by p38-SQSTM1/p62 and JNK-BNIP3L/Nix signaling in lung cancer cells.	arsenite	0-8	BCL2 interacting protein 3 like	Homo sapiens	69-75
34861471-0	2022	Arsenite-induced cytotoxicity is regulated by p38-SQSTM1/p62 and JNK-BNIP3L/Nix signaling in lung cancer cells.	arsenite	0-8	BCL2 interacting protein 3 like	Homo sapiens	76-79
34861471-3	2022	Here, we report that arsenite-induced cytotoxicity is regulated by SQSTM1/p62 and BNIP3L/Nix signaling in non-small-cell lung cancer H460 cells.	arsenite	21-29	sequestosome 1	Homo sapiens	67-73
34861471-3	2022	Here, we report that arsenite-induced cytotoxicity is regulated by SQSTM1/p62 and BNIP3L/Nix signaling in non-small-cell lung cancer H460 cells.	arsenite	21-29	sequestosome 1	Homo sapiens	74-77
34861471-3	2022	Here, we report that arsenite-induced cytotoxicity is regulated by SQSTM1/p62 and BNIP3L/Nix signaling in non-small-cell lung cancer H460 cells.	arsenite	21-29	BCL2 interacting protein 3 like	Homo sapiens	82-88
34861471-3	2022	Here, we report that arsenite-induced cytotoxicity is regulated by SQSTM1/p62 and BNIP3L/Nix signaling in non-small-cell lung cancer H460 cells.	arsenite	21-29	BCL2 interacting protein 3 like	Homo sapiens	89-92
34861471-4	2022	Arsenite exposure resulted in dose-dependent growth inhibition, which was associated with apoptosis, as demonstrated by depolarized mitochondrial membrane potential and cleavage of caspase-8, caspase-3, PARP-1, and Bax.	arsenite	0-8	caspase 8	Homo sapiens	181-190
34861471-4	2022	Arsenite exposure resulted in dose-dependent growth inhibition, which was associated with apoptosis, as demonstrated by depolarized mitochondrial membrane potential and cleavage of caspase-8, caspase-3, PARP-1, and Bax.	arsenite	0-8	caspase 3	Homo sapiens	192-201
34861471-4	2022	Arsenite exposure resulted in dose-dependent growth inhibition, which was associated with apoptosis, as demonstrated by depolarized mitochondrial membrane potential and cleavage of caspase-8, caspase-3, PARP-1, and Bax.	arsenite	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	203-209
34861471-4	2022	Arsenite exposure resulted in dose-dependent growth inhibition, which was associated with apoptosis, as demonstrated by depolarized mitochondrial membrane potential and cleavage of caspase-8, caspase-3, PARP-1, and Bax.	arsenite	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	215-218
34861471-5	2022	The autophagy adaptor p62 was detected in the monomeric and multiple high-molecular-weight (HMW) forms, and protein levels were upregulated depending on both arsenite concentrations (<=45 muM) and exposure times (<24 h).	arsenite	158-166	sequestosome 1	Homo sapiens	22-25
34861471-7	2022	Expression of Nix, a mitochondrial outer membrane protein, continued to increase with arsenite concentration and exposure time; it was detected in the monomeric and multiple HMW forms.	arsenite	86-94	BCL2 interacting protein 3 like	Homo sapiens	14-17
34861471-8	2022	Soon after arsenite exposure, p62 colocalized with Nix in the cytoplasm, and p62 knockdown reduced the Nix levels and increased the LC3-II levels.	arsenite	11-19	sequestosome 1	Homo sapiens	30-33
34861471-8	2022	Soon after arsenite exposure, p62 colocalized with Nix in the cytoplasm, and p62 knockdown reduced the Nix levels and increased the LC3-II levels.	arsenite	11-19	sequestosome 1	Homo sapiens	77-80
34929507-0	2022	Downregulation of beclin 1 restores arsenite-induced impaired autophagic flux by improving the lysosomal function in cortex.	arsenite	36-44	beclin 1	Homo sapiens	18-26
34929507-3	2022	In this study, both adult beclin 1+/+ and beclin 1+/- mice were employed to establish a model of chronic arsenite exposure by treating with arsenite via drinking water for 6 months.	arsenite	140-148	beclin 1, autophagy related	Mus musculus	26-34
34929507-5	2022	Heterozygous disruption of beclin 1 in animals remarkably alleviated the neurotoxic effects of arsenite.	arsenite	95-103	beclin 1, autophagy related	Mus musculus	27-35
34929507-9	2022	Either knockdown of beclin in cells or heterozygous disruption of beclin 1 in animals remarkably alleviated the lysosomal dysfunction induced by arsenite.	arsenite	145-153	beclin 1	Homo sapiens	66-74
34929507-10	2022	These findings indicate that downregulation of beclin 1 could restore arsenite-induced impaired autophagic flux possibly through improving lysosomal function, and suggesting that regulation of autophagy via beclin 1 would be an alternative approach for the treatment of arsenite neurotoxicity.	arsenite	70-78	beclin 1	Homo sapiens	47-55
34929507-10	2022	These findings indicate that downregulation of beclin 1 could restore arsenite-induced impaired autophagic flux possibly through improving lysosomal function, and suggesting that regulation of autophagy via beclin 1 would be an alternative approach for the treatment of arsenite neurotoxicity.	arsenite	270-278	beclin 1	Homo sapiens	47-55
34798142-7	2022	Knockdown or inhibition of NOX decreased arsenite-induced ROS, PARP-1 oxidation and DNA damage retention, while restoring arsenite inhibition of PARP-1 activity.	arsenite	41-49	poly (ADP-ribose) polymerase family, member 1	Mus musculus	63-69
34798142-7	2022	Knockdown or inhibition of NOX decreased arsenite-induced ROS, PARP-1 oxidation and DNA damage retention, while restoring arsenite inhibition of PARP-1 activity.	arsenite	41-49	poly (ADP-ribose) polymerase family, member 1	Mus musculus	145-151
34798142-7	2022	Knockdown or inhibition of NOX decreased arsenite-induced ROS, PARP-1 oxidation and DNA damage retention, while restoring arsenite inhibition of PARP-1 activity.	arsenite	122-130	poly (ADP-ribose) polymerase family, member 1	Mus musculus	145-151
34798142-8	2022	The NOX2 isoform was determined to be the major contributor to arsenite-induced ROS generation and DNA damage retention.	arsenite	63-71	cytochrome b-245 beta chain	Homo sapiens	4-8
34378050-5	2021	We show that sorbitol drives TDP-43 redistribution to the cytoplasm, while arsenite induces the recruitment of cytoplasmic TDP-43 to TIA-1 positive SGs.	arsenite	75-83	TAR DNA binding protein	Homo sapiens	123-129
34378050-5	2021	We show that sorbitol drives TDP-43 redistribution to the cytoplasm, while arsenite induces the recruitment of cytoplasmic TDP-43 to TIA-1 positive SGs.	arsenite	75-83	TIA1 cytotoxic granule associated RNA binding protein	Homo sapiens	133-138
34874156-5	2021	We find that a brief exposure of HEK293T cells to meta-arsenite increases the affinity of two dozen proteins to DNAJB8, including known arsenite-sensitive proteins.	arsenite	136-144	DnaJ heat shock protein family (Hsp40) member B8	Homo sapiens	112-118
34846385-0	2021	Arsenite-loaded albumin nanoparticles for targeted synergistic chemo-photothermal therapy of HCC.	arsenite	0-8	albumin	Homo sapiens	16-23
34861471-10	2022	p38 inhibition markedly increased arsenite-induced Nix protein and reduced p62 protein levels, resulting in increased autophagy and apoptosis.	arsenite	34-42	BCL2 interacting protein 3 like	Homo sapiens	51-54
34861471-10	2022	p38 inhibition markedly increased arsenite-induced Nix protein and reduced p62 protein levels, resulting in increased autophagy and apoptosis.	arsenite	34-42	sequestosome 1	Homo sapiens	75-78
34861471-12	2022	Our results suggest that arsenite-induced cytotoxicity is modulated by the coordinated action of p62 and Nix through MAPK.	arsenite	25-33	sequestosome 1	Homo sapiens	97-100
34861471-12	2022	Our results suggest that arsenite-induced cytotoxicity is modulated by the coordinated action of p62 and Nix through MAPK.	arsenite	25-33	BCL2 interacting protein 3 like	Homo sapiens	105-108
34390821-0	2021	Thioredoxin 1 is required for stress granule assembly upon arsenite-induced oxidative stress.	arsenite	59-67	thioredoxin	Homo sapiens	0-13
34089843-5	2021	Arsenite induced a slow and limited mobilization of Ca2+ from IP3R via a saturable mechanism, failing to increase the (Ca2+)m. This effect was however associated with the triggering of an intraluminal crosstalk between the IP3R and the ryanodine receptor (RyR), causing a large and concentration dependent release of Ca2+ from RyR and a parallel increase in (Ca2+)m. Thus, the Ca2+-dependent mitoO2-.	arsenite	0-8	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	62-66
34089843-5	2021	Arsenite induced a slow and limited mobilization of Ca2+ from IP3R via a saturable mechanism, failing to increase the (Ca2+)m. This effect was however associated with the triggering of an intraluminal crosstalk between the IP3R and the ryanodine receptor (RyR), causing a large and concentration dependent release of Ca2+ from RyR and a parallel increase in (Ca2+)m. Thus, the Ca2+-dependent mitoO2-.	arsenite	0-8	ryanodine receptor 2	Homo sapiens	327-330
34768886-0	2021	Effects of the Toxic Metals Arsenite and Cadmium on alpha-Synuclein Aggregation In Vitro and in Cells.	arsenite	28-36	synuclein alpha	Homo sapiens	52-67
34964269-2	2022	Here, we showed that arsenite-induced proteotoxic stress resulted in upregulation of Arabidopsis homologous PUB22 and PUB23 U-box E3 ubiquitin ligases and that pub22pub23 double mutants displayed arsenite-insensitive seed germination and root growth phenotypes.	arsenite	21-29	plant U-box 22	Arabidopsis thaliana	108-113
34964269-2	2022	Here, we showed that arsenite-induced proteotoxic stress resulted in upregulation of Arabidopsis homologous PUB22 and PUB23 U-box E3 ubiquitin ligases and that pub22pub23 double mutants displayed arsenite-insensitive seed germination and root growth phenotypes.	arsenite	21-29	plant U-box 23	Arabidopsis thaliana	118-123
34964269-4	2022	These results suggest that PUB22/PUB23 play a critical role in arsenite-induced proteotoxic stress response via negative regulation of 26S proteasome integrity.	arsenite	63-71	plant U-box 22	Arabidopsis thaliana	27-32
34964269-4	2022	These results suggest that PUB22/PUB23 play a critical role in arsenite-induced proteotoxic stress response via negative regulation of 26S proteasome integrity.	arsenite	63-71	plant U-box 23	Arabidopsis thaliana	33-38
34764389-0	2021	Arsenite exposure inhibits the erythroid differentiation of human hematopoietic progenitor CD34+ cells and causes decreased levels of hemoglobin.	arsenite	0-8	CD34 molecule	Homo sapiens	91-95
34390821-2	2021	Arsenic exerts its pronounced cellular toxicity through its trivalent oxide arsenite (ASN), which directly inhibits numerous proteins including Thioredoxin 1 (Trx1), and causes severe oxidative stress.	arsenite	86-89	thioredoxin	Homo sapiens	144-157
34390821-2	2021	Arsenic exerts its pronounced cellular toxicity through its trivalent oxide arsenite (ASN), which directly inhibits numerous proteins including Thioredoxin 1 (Trx1), and causes severe oxidative stress.	arsenite	86-89	thioredoxin	Homo sapiens	159-163
34390821-6	2021	Trx1 is required for the assembly of ASN-induced SGs, but not for SGs induced by energy deprivation or heat shock.	arsenite	37-40	thioredoxin	Homo sapiens	0-4
34390821-7	2021	Importantly, our results show that Trx1 is essential for cell survival upon acute exposure to ASN, through a mechanism that is independent of translation inhibition.	arsenite	94-97	thioredoxin	Homo sapiens	35-39
34469566-4	2021	At endogenous levels, YB-1 facilitates SG disassembly during arsenite stress recovery.	arsenite	61-69	Y-box binding protein 1	Homo sapiens	22-26
34244458-5	2021	ER-associated SG assembly was also observed during arsenite stress, suggesting broad roles for the ER in SG biogenesis.	arsenite	51-59	epiregulin	Homo sapiens	0-2
34169068-7	2021	Wild type and mutant TDP-43 appeared to be largely retained in the nucleus following exposure to arsenite-induced oxidative stress.	arsenite	97-105	TAR DNA binding protein	Mus musculus	21-27
34572530-3	2021	In this report, we demonstrate that Arsenite Inducible Regulatory Particle-Associate Protein (AIRAP), previously reported as a proteasomal adaptor required for maintaining proteasomal flux during arsenite exposure, can directly bind arsenite molecules.	arsenite	196-204	zinc finger AN1-type containing 2A	Homo sapiens	36-92
34572530-3	2021	In this report, we demonstrate that Arsenite Inducible Regulatory Particle-Associate Protein (AIRAP), previously reported as a proteasomal adaptor required for maintaining proteasomal flux during arsenite exposure, can directly bind arsenite molecules.	arsenite	196-204	zinc finger AN1-type containing 2A	Homo sapiens	94-99
34572530-3	2021	In this report, we demonstrate that Arsenite Inducible Regulatory Particle-Associate Protein (AIRAP), previously reported as a proteasomal adaptor required for maintaining proteasomal flux during arsenite exposure, can directly bind arsenite molecules.	arsenite	233-241	zinc finger AN1-type containing 2A	Homo sapiens	36-92
34572530-3	2021	In this report, we demonstrate that Arsenite Inducible Regulatory Particle-Associate Protein (AIRAP), previously reported as a proteasomal adaptor required for maintaining proteasomal flux during arsenite exposure, can directly bind arsenite molecules.	arsenite	233-241	zinc finger AN1-type containing 2A	Homo sapiens	94-99
34572530-4	2021	We further show that arsenite inhibits Psmd14/Rpn11 metalloprotease deubiquitination activity by substituting zinc binding to the MPN/JAMM domain.	arsenite	21-29	proteasome 26S subunit, non-ATPase 14	Homo sapiens	39-45
34425169-9	2021	A common element in the changing response of cells to arsenite over time appears to involve up-regulation of MDM2 by inflammatory signaling (through AP-1 and NF-kappaB), leading to inhibition of P53 function.	arsenite	54-62	MDM2 proto-oncogene	Homo sapiens	109-113
34425169-9	2021	A common element in the changing response of cells to arsenite over time appears to involve up-regulation of MDM2 by inflammatory signaling (through AP-1 and NF-kappaB), leading to inhibition of P53 function.	arsenite	54-62	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	149-153
34425169-9	2021	A common element in the changing response of cells to arsenite over time appears to involve up-regulation of MDM2 by inflammatory signaling (through AP-1 and NF-kappaB), leading to inhibition of P53 function.	arsenite	54-62	tumor protein p53	Homo sapiens	195-198
34169068-8	2021	Upon arsenite removal, mutant TDP-43 clearly accumulated within HuR positive SGs in the cytoplasm, whereas TDP-43 W T remained mostly within the nucleus.	arsenite	5-13	TAR DNA binding protein	Mus musculus	30-36
34169068-8	2021	Upon arsenite removal, mutant TDP-43 clearly accumulated within HuR positive SGs in the cytoplasm, whereas TDP-43 W T remained mostly within the nucleus.	arsenite	5-13	ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)	Mus musculus	64-67
34453993-8	2021	We therefore conclude that low dose arsenite-induced mitoO2- formation, and the resulting mitochondrial dysfunction and toxicity, are prerequisite of cell types expressing the RyR in close apposition with mitochondria.	arsenite	36-44	ryanodine receptor 2	Homo sapiens	176-179
35604368-7	2022	Loss of SMGL-1 or RAB-8 compromised resistance to environmental colchicine, arsenite, and pathogenic bacteria.	arsenite	76-84	Uncharacterized protein	Caenorhabditis elegans	8-14
35604368-7	2022	Loss of SMGL-1 or RAB-8 compromised resistance to environmental colchicine, arsenite, and pathogenic bacteria.	arsenite	76-84	RAB family	Caenorhabditis elegans	18-23
35569872-1	2022	The present study demonstrate the first time usage of poly (HPMA-s-GPMA) copolymer for the fabrication of three-component based aptasensor for simple, selective, rapid and label free detection of arsenite (As3+).	arsenite	196-204	PDS5 cohesin associated factor B	Homo sapiens	206-209
35624898-0	2022	Mitochondrial ROS, ER Stress, and Nrf2 Crosstalk in the Regulation of Mitochondrial Apoptosis Induced by Arsenite.	arsenite	105-113	NFE2 like bZIP transcription factor 2	Homo sapiens	34-38
35244730-2	2022	In human and mouse, inorganic arsenic (iAs) is metabolized in a series of methylation steps catalyzed by arsenic (3) methyltransferase (AS3MT), forming methylated arsenite (MAsIII), dimethylarsenite (DMAIII) and the volatile trimethylarsine (TMA).	arsenite	163-171	arsenite methyltransferase	Mus musculus	136-141
35513407-4	2022	Here, we report a multiplex small RNA-seq library preparation method (MSR-seq) to investigate cellular small RNA and mRNA response to heat shock, hydrogen peroxide, and arsenite stress.	arsenite	169-177	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	70-73
35090851-10	2022	In sum, arsenite exposure during pregnancy transgenerationally affects glucose metabolism, which is related to altered levels of IGF2 and KCNQ1.	arsenite	8-16	insulin-like growth factor 2	Mus musculus	129-133
35000760-0	2022	Corrigendum to "The yeast permease Acr3p is a dual arsenite and antimonite plasma membrane transporter" (Biochim.	arsenite	51-59	Arr3p	Saccharomyces cerevisiae S288C	35-40
35090851-10	2022	In sum, arsenite exposure during pregnancy transgenerationally affects glucose metabolism, which is related to altered levels of IGF2 and KCNQ1.	arsenite	8-16	potassium voltage-gated channel, subfamily Q, member 1	Mus musculus	138-143
35378400-7	2022	In this study, we found that arsenite induced microglial activation through p38 MAPK signaling pathway, leading to the production of TNF-alpha.	arsenite	29-37	tumor necrosis factor	Homo sapiens	133-142
35378400-9	2022	Our findings suggested that necroptosis induced by microglia-derived TNF-alpha upon arsenite exposure partially played a role in arsenic-induced cell death which underlie the fundamental event of arsenic-related neurotoxicity.	arsenite	84-92	tumor necrosis factor	Homo sapiens	69-78
35363433-8	2022	Finally, alteration of the m6 A levels via knockdown or enhancement of the METTL3 protein could antagonize or aggravate arsenite-induced imbalanced inflammatory homeostasis and human keratinocyte damage in HaCaT cells.	arsenite	120-128	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	75-81
35378400-0	2022	TNF-alpha derived from arsenite-induced microglia activation mediated neuronal necroptosis.	arsenite	23-31	tumor necrosis factor	Homo sapiens	0-9
35323907-0	2022	Etp1 confers arsenite resistance by affecting ACR3 expression.	arsenite	13-21	Etp1p	Saccharomyces cerevisiae S288C	0-4
35323907-0	2022	Etp1 confers arsenite resistance by affecting ACR3 expression.	arsenite	13-21	Arr3p	Saccharomyces cerevisiae S288C	46-50
35323907-5	2022	We show that Etp1 is required for optimal growth in the presence of trivalent arsenite and for optimal expression of the arsenite export protein encoded by ACR3.	arsenite	78-86	Etp1p	Saccharomyces cerevisiae S288C	13-17
35323907-5	2022	We show that Etp1 is required for optimal growth in the presence of trivalent arsenite and for optimal expression of the arsenite export protein encoded by ACR3.	arsenite	121-129	Etp1p	Saccharomyces cerevisiae S288C	13-17
35323907-5	2022	We show that Etp1 is required for optimal growth in the presence of trivalent arsenite and for optimal expression of the arsenite export protein encoded by ACR3.	arsenite	121-129	Arr3p	Saccharomyces cerevisiae S288C	156-160
35189109-0	2022	Crosstalk between ERO1alpha and ryanodine receptor in arsenite-dependent mitochondrial ROS formation.	arsenite	54-62	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	18-27
35189109-0	2022	Crosstalk between ERO1alpha and ryanodine receptor in arsenite-dependent mitochondrial ROS formation.	arsenite	54-62	ryanodine receptor 2	Homo sapiens	32-50
35189109-1	2022	Arsenite, a well-established human carcinogen and toxic compound, promotes the formation of mitochondrial superoxide (mitoO2-.) via a Ca2+-dependent mechanism, in which an initial stimulation of the inositol 1, 4, 5-trisphosphate receptor (IP3R) is followed by the activation of the ryanodine receptor (RyR), critical for providing Ca2+ to the mitochondria.	arsenite	0-8	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	240-244
35189109-1	2022	Arsenite, a well-established human carcinogen and toxic compound, promotes the formation of mitochondrial superoxide (mitoO2-.) via a Ca2+-dependent mechanism, in which an initial stimulation of the inositol 1, 4, 5-trisphosphate receptor (IP3R) is followed by the activation of the ryanodine receptor (RyR), critical for providing Ca2+ to the mitochondria.	arsenite	0-8	ryanodine receptor 2	Homo sapiens	283-301
35189109-1	2022	Arsenite, a well-established human carcinogen and toxic compound, promotes the formation of mitochondrial superoxide (mitoO2-.) via a Ca2+-dependent mechanism, in which an initial stimulation of the inositol 1, 4, 5-trisphosphate receptor (IP3R) is followed by the activation of the ryanodine receptor (RyR), critical for providing Ca2+ to the mitochondria.	arsenite	0-8	ryanodine receptor 2	Homo sapiens	303-306
35189109-2	2022	We now report that, under the same conditions, arsenite triggers endoplasmic reticulum (ER) stress and a threefold increase in ER oxidoreductin 1alpha (ERO1 alpha) levels in proliferating U937 cells.	arsenite	47-55	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	127-162
35189109-6	2022	Moreover, ERO1 alpha knockout C2C12 myotubes responded to arsenite as their wild type counterpart supplemented with EN460.	arsenite	58-66	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	10-20
35189109-7	2022	As a final note, arsenite enhanced the expression of ERO1 alpha via a mechanism mediated by Ca2+ release from both the IP3R and RyR.	arsenite	17-25	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	53-63
35189109-7	2022	As a final note, arsenite enhanced the expression of ERO1 alpha via a mechanism mediated by Ca2+ release from both the IP3R and RyR.	arsenite	17-25	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	119-123
35189109-7	2022	As a final note, arsenite enhanced the expression of ERO1 alpha via a mechanism mediated by Ca2+ release from both the IP3R and RyR.	arsenite	17-25	ryanodine receptor 1, skeletal muscle	Mus musculus	128-131
35189109-8	2022	We therefore conclude that arsenite activates a positive feedback amplification cycle between Ca2+ levels and ERO1 alpha in the ER, by which IP3R-dependent Ca2+ induces ERO1 alpha and ERO1 alpha promotes Ca2+ release via RyR, thereby amplifying the initial Ca2+ load and causing the mitochondrial accumulation of the cation, critical for mitoO2-.	arsenite	27-35	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	110-120
35189109-8	2022	We therefore conclude that arsenite activates a positive feedback amplification cycle between Ca2+ levels and ERO1 alpha in the ER, by which IP3R-dependent Ca2+ induces ERO1 alpha and ERO1 alpha promotes Ca2+ release via RyR, thereby amplifying the initial Ca2+ load and causing the mitochondrial accumulation of the cation, critical for mitoO2-.	arsenite	27-35	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	141-145
35189109-8	2022	We therefore conclude that arsenite activates a positive feedback amplification cycle between Ca2+ levels and ERO1 alpha in the ER, by which IP3R-dependent Ca2+ induces ERO1 alpha and ERO1 alpha promotes Ca2+ release via RyR, thereby amplifying the initial Ca2+ load and causing the mitochondrial accumulation of the cation, critical for mitoO2-.	arsenite	27-35	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	169-179
35189109-8	2022	We therefore conclude that arsenite activates a positive feedback amplification cycle between Ca2+ levels and ERO1 alpha in the ER, by which IP3R-dependent Ca2+ induces ERO1 alpha and ERO1 alpha promotes Ca2+ release via RyR, thereby amplifying the initial Ca2+ load and causing the mitochondrial accumulation of the cation, critical for mitoO2-.	arsenite	27-35	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	184-194
35189109-8	2022	We therefore conclude that arsenite activates a positive feedback amplification cycle between Ca2+ levels and ERO1 alpha in the ER, by which IP3R-dependent Ca2+ induces ERO1 alpha and ERO1 alpha promotes Ca2+ release via RyR, thereby amplifying the initial Ca2+ load and causing the mitochondrial accumulation of the cation, critical for mitoO2-.	arsenite	27-35	ryanodine receptor 1, skeletal muscle	Mus musculus	221-224
35363433-3	2022	In human keratinocytes, arsenite increased the levels of m6 A methylation by upregulating the RNA methyltransferase like 3 (METTL3), mediating the disordered secretion of indicators that reflect inflammatory homeostasis (IL-6, IL-17, and IL-10).	arsenite	24-32	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	124-130
35363433-3	2022	In human keratinocytes, arsenite increased the levels of m6 A methylation by upregulating the RNA methyltransferase like 3 (METTL3), mediating the disordered secretion of indicators that reflect inflammatory homeostasis (IL-6, IL-17, and IL-10).	arsenite	24-32	interleukin 6	Homo sapiens	221-225
35363433-3	2022	In human keratinocytes, arsenite increased the levels of m6 A methylation by upregulating the RNA methyltransferase like 3 (METTL3), mediating the disordered secretion of indicators that reflect inflammatory homeostasis (IL-6, IL-17, and IL-10).	arsenite	24-32	interleukin 17A	Homo sapiens	227-232
35363433-3	2022	In human keratinocytes, arsenite increased the levels of m6 A methylation by upregulating the RNA methyltransferase like 3 (METTL3), mediating the disordered secretion of indicators that reflect inflammatory homeostasis (IL-6, IL-17, and IL-10).	arsenite	24-32	interleukin 10	Homo sapiens	238-243
35124418-7	2022	As expected, silencing of NFE2L1-L gene strikingly inhibited the arsenite-induced EMT and the subsequent malignant transformation.	arsenite	65-73	NFE2 like bZIP transcription factor 1	Homo sapiens	26-34
35124418-10	2022	Collectively, our data suggest that NFE2L1-L promotes EMT by positively regulating SNAIL1 transcription, and is involved in malignant transformation induced by arsenite.	arsenite	160-168	NFE2 like bZIP transcription factor 1	Homo sapiens	36-44
2775267-3	1989	Arsenite enhanced the phosphorylation of the same 28kDa proteins as tumor necrosis factor-alpha in the endothelial cells.	arsenite	0-8	tumor necrosis factor	Mus musculus	68-95
35124418-0	2022	Long-isoform NFE2L1 silencing inhibits acquisition of malignant phenotypes induced by arsenite in human bronchial epithelial cells.	arsenite	86-94	NFE2 like bZIP transcription factor 1	Homo sapiens	13-19
35124418-2	2022	Nuclear factor erythroid 2 like 1 (NFE2L1), a transcription factor belonging to CNC-bZIP family, regulates multiple important cellular functions in response to acute arsenite exposure.	arsenite	166-174	NFE2 like bZIP transcription factor 1	Homo sapiens	0-33
35124418-2	2022	Nuclear factor erythroid 2 like 1 (NFE2L1), a transcription factor belonging to CNC-bZIP family, regulates multiple important cellular functions in response to acute arsenite exposure.	arsenite	166-174	NFE2 like bZIP transcription factor 1	Homo sapiens	35-41
35124418-3	2022	However, the role of NFE2L1 in lung cancer induced by chronic arsenite exposure is unknown.	arsenite	62-70	NFE2 like bZIP transcription factor 1	Homo sapiens	21-27
2617833-0	1989	In vitro effects of cadmium and arsenite on glutathione peroxidase, aspartate and alanine aminotransferases, cholinesterase and glucose-6-phosphate dehydrogenase activities in blood.	arsenite	32-40	butyrylcholinesterase	Homo sapiens	109-123
2617833-0	1989	In vitro effects of cadmium and arsenite on glutathione peroxidase, aspartate and alanine aminotransferases, cholinesterase and glucose-6-phosphate dehydrogenase activities in blood.	arsenite	32-40	glucose-6-phosphate dehydrogenase	Homo sapiens	128-161
2617833-2	1989	Both human and rat blood glutathione peroxidase (GSH-Px) activities were adversely affected by As at the 0.8 and 1.6 micrograms/ml levels.	arsenite	95-97	glutathione peroxidase 1	Rattus norvegicus	49-55
2617833-7	1989	In the case of glutamyl pyruvate transaminase (GPT) both As and Cd had a marked effect, manifested in 70% and 78% inhibition, respectively.	arsenite	57-59	glutamic--pyruvic transaminase	Homo sapiens	15-45
2617833-7	1989	In the case of glutamyl pyruvate transaminase (GPT) both As and Cd had a marked effect, manifested in 70% and 78% inhibition, respectively.	arsenite	57-59	glutamic--pyruvic transaminase	Homo sapiens	47-50
2617833-8	1989	Blood glucose-6-phosphate dehydrogenase (G-G-PD) was inhibited by both Cd and As, however, within the concentration range used, only Cd inhibited it completely.	arsenite	78-80	glucose-6-phosphate dehydrogenase	Homo sapiens	6-39
2617833-9	1989	Cholinesterase (ChE) activity was inhibited completely by both Cd and As.	arsenite	70-72	butyrylcholinesterase	Homo sapiens	0-14
2617833-9	1989	Cholinesterase (ChE) activity was inhibited completely by both Cd and As.	arsenite	70-72	butyrylcholinesterase	Homo sapiens	16-19
2553734-0	1989	Arsenite inhibits two steps in the ubiquitin-dependent proteolytic pathway.	arsenite	0-8	ubiquitin	Bos taurus	35-44
2553734-4	1989	Concentrations of arsenite causing half-maximal inhibition in fraction II varied with the substrate, ranging from 0.025 mM (bovine alpha-lactalbumin) to 3.3 mM (reduced/carboxymethylated bovine serum albumin).	arsenite	18-26	lactalbumin alpha	Bos taurus	131-148
2553734-6	1989	Arsenite inhibited the Ub-dependent proteolytic pathway at one or both of two steps, depending on the substrate.	arsenite	0-8	ubiquitin	Bos taurus	23-25
2553734-9	1989	Arsenite inhibited substrate arginylation, and therefore also inhibited Ub conjugation.	arsenite	0-8	ubiquitin	Bos taurus	72-74
2553734-11	1989	2) Arsenite also inhibited Ub-substrate conjugate turnover, as shown in pulse-chase experiments.	arsenite	3-11	ubiquitin	Bos taurus	27-29
2553734-12	1989	For a given substrate, degradative (protease-dependent) and Ub regenerative (isopeptidase-dependent) components of conjugate turnover were similarly inhibited by arsenite.	arsenite	162-170	ubiquitin	Bos taurus	60-62
2553734-15	1989	Inhibition by arsenite of two steps in the Ub-dependent proteolytic pathway suggests that the relevant pathway components could possess this kind of structural/catalytic feature.	arsenite	14-22	ubiquitin	Bos taurus	43-45
2777774-3	1989	V8 protease digestion of p31 purified from PDGF-, TPA-, and arsenite-treated cells showed identical fragmentation patterns, demonstrating that these agents modulate synthesis of the same (or a highly similar) protein.	arsenite	60-68	ATPase, H+ transporting, lysosomal V1 subunit E1	Mus musculus	25-28
2777774-12	1989	Its nuclear localization and amino acid analysis demonstrate that p31 is not heme oxygenase, a 32-kDa arsenite-induced microsomal protein.	arsenite	102-110	ATPase, H+ transporting, lysosomal V1 subunit E1	Mus musculus	66-69
35001170-3	2022	PML proteins are rapidly modified both with SUMO2/3 and SUMO1 after exposure to arsenite (As3+) and SUMOylated PML are further ubiquitinated and degraded by proteasomes.	arsenite	80-88	PML nuclear body scaffold	Homo sapiens	0-3
35001170-3	2022	PML proteins are rapidly modified both with SUMO2/3 and SUMO1 after exposure to arsenite (As3+) and SUMOylated PML are further ubiquitinated and degraded by proteasomes.	arsenite	80-88	small ubiquitin like modifier 2	Homo sapiens	44-51
35001170-3	2022	PML proteins are rapidly modified both with SUMO2/3 and SUMO1 after exposure to arsenite (As3+) and SUMOylated PML are further ubiquitinated and degraded by proteasomes.	arsenite	80-88	small ubiquitin like modifier 1	Homo sapiens	56-61
2799859-1	1989	Labeled 4,4-dimethyl-5 alpha -cholesta-8,24-dien-3 beta-ol (4,4-dimethylzymosterol) was prepared by incubating labeled mevalonate with rat liver extracts in the presence of arsenite and lanosterol.	arsenite	173-181	integrin subunit beta 1	Rattus norvegicus	51-58
2791215-3	1989	However, addition of arsenite 5 h after cell dilution, i.e. when ODC was already induced, appeared to stabilize the enzyme.	arsenite	21-29	ornithine decarboxylase 1	Homo sapiens	65-68
2557196-6	1989	We conclude that the hsp68 promoter region included in the construct contains sufficient sequence information for heat and arsenite inducibility, but it does not contain sequences controlling tissue-specific expression during development.	arsenite	123-131	heat shock protein 1A	Mus musculus	21-26
2449436-11	1988	In contrast, the ArsA protein exhibited an ATPase activity which was dependent on the presence of arsenite or antimonate.	arsenite	98-106	arylsulfatase A	Homo sapiens	17-21
2449436-11	1988	In contrast, the ArsA protein exhibited an ATPase activity which was dependent on the presence of arsenite or antimonate.	arsenite	98-106	dynein axonemal heavy chain 8	Homo sapiens	43-49
6710506-0	1984	Evaluation of the effect of BAL (2,3-dimercaptopropanol) on arsenite-induced teratogenesis in mice.	arsenite	60-68	poly (ADP-ribose) polymerase family, member 9	Mus musculus	28-31
2947567-7	1986	Inhibitions of N-acetyl-beta-glucosaminidase activities of both isoenzymes by metal salts and organic anions were comparable; acetate and arsenite were effective inhibitors for both isoenzymes.	arsenite	138-146	O-GlcNAcase	Homo sapiens	15-44
3316977-1	1987	Several known inducers of the heat shock response (heat stress, arsenite, and heavy metals) were shown to cause a significant elevation of c-fos mRNA in HeLa cells.	arsenite	64-72	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	139-144
3316977-4	1987	Treatment of HeLa cells with arsenite or heavy metals also resulted in increased levels of hsp 70, as well as c-fos mRNA.	arsenite	29-37	heat shock protein family A (Hsp70) member 4	Homo sapiens	91-97
3316977-4	1987	Treatment of HeLa cells with arsenite or heavy metals also resulted in increased levels of hsp 70, as well as c-fos mRNA.	arsenite	29-37	steroid sulfatase	Homo sapiens	107-111
3316977-4	1987	Treatment of HeLa cells with arsenite or heavy metals also resulted in increased levels of hsp 70, as well as c-fos mRNA.	arsenite	29-37	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	112-115
3597553-7	1987	Arsenite-treated cells showed a great deal of thermotolerance (TTR of about 10) when they were heated at 45 degrees C after 5 hr of heating at 43 degrees C, compared with less thermotolerance (TTR of about 2) for the CHM-treated cells heated at 45 degrees C after 5 hr of heating at 43 degrees C. Therefore, there are two different phenomena.	arsenite	0-8	rab proteins geranylgeranyltransferase component A 1	Cricetulus griseus	217-220
3332481-8	1987	Other experiments suggest such hsp inducers as heat, ethanol, arsenite, or oxygenation after anoxia, may cause protein damage through oxygen-derived free radical action.	arsenite	62-70	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	31-34
3982389-0	1985	Butyrylcholinesterase: inhibition by arsenite, fluoride, and other ligands, cooperativity in binding.	arsenite	37-45	butyrylcholinesterase	Homo sapiens	0-21
3982389-1	1985	Arsenite is a quasi-irreversible inhibitor of human serum butyrylcholinesterase with a dissociation constant of 0.129 mM at pH 7.4, 25 degrees, 0.067 M phosphate, mu = 0.17 M. The inhibition process is second order with a rate constant of 340 M-1 min-1.	arsenite	0-8	butyrylcholinesterase	Homo sapiens	58-79
3982389-1	1985	Arsenite is a quasi-irreversible inhibitor of human serum butyrylcholinesterase with a dissociation constant of 0.129 mM at pH 7.4, 25 degrees, 0.067 M phosphate, mu = 0.17 M. The inhibition process is second order with a rate constant of 340 M-1 min-1.	arsenite	0-8	CD59 molecule (CD59 blood group)	Homo sapiens	247-252
3968080-0	1985	Acetylcholinesterase: inhibition by tetranitromethane and arsenite.	arsenite	58-66	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
3871425-1	1985	The genes encoding for beta-lactamase (bla+) and resistance to metallic ions (cadmium, mercury, lead, arsenate, and arsenite) were located in a 56.2-kilobase plasmid, pZA10, isolated from a clinical strain, Staphylococcus aureus 6344.	arsenite	116-124	beta-lactamase	Staphylococcus aureus	23-37
6092938-5	1984	Northern blot analysis of RNA from arsenite-induced RTG-2 cells, with the trout hsp70 cDNAs as probes, revealed the presence of three hsp70 mRNA species.	arsenite	35-43	heat shock protein family A (Hsp70) member 8b	Oncorhynchus mykiss	134-139
6424670-6	1984	Thus, the arsenite-induced changes in methylation of hsp70 polypeptides are not a generalized phenomenon and may reflect a modulation in the structure or function of these two polypeptides after their induced synthesis by this chemical.	arsenite	10-18	heat shock protein family A (Hsp70) member 2	Gallus gallus	53-58
6710506-1	1984	The effect of the chelating agent dimercaprol (BAL) on the embryotoxic and teratogenic effects of arsenite (As3+) was determined.	arsenite	98-106	poly (ADP-ribose) polymerase family, member 9	Mus musculus	47-50
6710506-2	1984	BAL (sc, 30 mg/kg) was administered to pregnant CD-1 mice, either 8 and 4 hr prior to or 4 and 8 hr after a 12-mg/kg ip dose of arsenite; other females received a single sc injection of 60 mg/kg BAL concurrently with the arsenite.	arsenite	128-136	poly (ADP-ribose) polymerase family, member 9	Mus musculus	0-3
6710506-2	1984	BAL (sc, 30 mg/kg) was administered to pregnant CD-1 mice, either 8 and 4 hr prior to or 4 and 8 hr after a 12-mg/kg ip dose of arsenite; other females received a single sc injection of 60 mg/kg BAL concurrently with the arsenite.	arsenite	221-229	poly (ADP-ribose) polymerase family, member 9	Mus musculus	0-3
6710506-6	1984	When BAL was given prior to arsenite on Day 9, incidences of prenatal mortality and skeletal malformation were significantly diminished, and on Day 12, BAL protected against fetocidal effects of arsenite when given concurrently with the arsenite.	arsenite	195-203	poly (ADP-ribose) polymerase family, member 9	Mus musculus	5-8
6710506-6	1984	When BAL was given prior to arsenite on Day 9, incidences of prenatal mortality and skeletal malformation were significantly diminished, and on Day 12, BAL protected against fetocidal effects of arsenite when given concurrently with the arsenite.	arsenite	195-203	poly (ADP-ribose) polymerase family, member 9	Mus musculus	152-155
6710506-6	1984	When BAL was given prior to arsenite on Day 9, incidences of prenatal mortality and skeletal malformation were significantly diminished, and on Day 12, BAL protected against fetocidal effects of arsenite when given concurrently with the arsenite.	arsenite	195-203	poly (ADP-ribose) polymerase family, member 9	Mus musculus	5-8
6710506-6	1984	When BAL was given prior to arsenite on Day 9, incidences of prenatal mortality and skeletal malformation were significantly diminished, and on Day 12, BAL protected against fetocidal effects of arsenite when given concurrently with the arsenite.	arsenite	195-203	poly (ADP-ribose) polymerase family, member 9	Mus musculus	152-155
6639069-0	1983	The inhibition of acetylcholinesterase by arsenite and fluoride.	arsenite	42-50	acetylcholinesterase (Cartwright blood group)	Homo sapiens	18-38
6639069-1	1983	The effect of fluoride on the rate of reaction of acetylcholinesterase with arsenite, on the rate of dissociation of the enzyme-arsenite complex, and on the equilibrium between enzyme and arsenite was studied.	arsenite	76-84	acetylcholinesterase (Cartwright blood group)	Homo sapiens	50-70
6821333-2	1982	Following transfection of COS cells, no significant amount of Drosophila hsp70 RNA was detected at 37 degrees C. In contrast, a heat-shock at 43 degrees C or arsenite poisoning at 37 degrees C induced the massive production of Drosophila hsp70 RNA of correct size and faithful 5" ends.	arsenite	158-166	Heat-shock-protein-70Ab	Drosophila melanogaster	238-243
16662848-4	1983	Light activation of phosphoenolpyruvate carboxylase and NADP-malate dehydrogenase was completely diminished when the epidermal strips were incubated for 2 hours in light with either sulfite or arsenite at 10 micromolar.	arsenite	193-201	phosphoenolpyruvate carboxykinase 1	Homo sapiens	20-51
7157414-1	1982	Rat liver mitochondria contain an aldehyde dehydrogenase (ALDH, EC 1.2.1.3) with a low Km for acetaldehyde (2 microM) which is susceptible to inhibition by a variety of agents including p-chloromercuribenzoate and arsenite.	arsenite	214-222	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	34-56
7157414-1	1982	Rat liver mitochondria contain an aldehyde dehydrogenase (ALDH, EC 1.2.1.3) with a low Km for acetaldehyde (2 microM) which is susceptible to inhibition by a variety of agents including p-chloromercuribenzoate and arsenite.	arsenite	214-222	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	58-62
6301524-0	1983	Electron paramagnetic resonance and potentiometric studies of arsenite interaction with the molybdenum centers of xanthine oxidase, xanthine dehydrogenase, and aldehyde oxidase: a specific stabilization of the molybdenum(V) oxidation state.	arsenite	62-70	xanthine dehydrogenase	Homo sapiens	132-154
6301524-0	1983	Electron paramagnetic resonance and potentiometric studies of arsenite interaction with the molybdenum centers of xanthine oxidase, xanthine dehydrogenase, and aldehyde oxidase: a specific stabilization of the molybdenum(V) oxidation state.	arsenite	62-70	aldehyde oxidase 1	Homo sapiens	160-176
18963324-0	1983	Determination of arsenite, arsenate and monomethylarsonic acid in aqueous samples by gas chromatography of their 2,3-dimercaptopropanol (bal) complexes.	arsenite	17-25	poly(ADP-ribose) polymerase family member 9	Homo sapiens	137-140
210844-0	1978	The interaction of arsenite with the molybdenum center of chicken liver xanthine dehydrogenase.	arsenite	19-27	xanthine dehydrogenase	Gallus gallus	72-94
728403-4	1978	o-Iodosobenzoate, Cd2+, and the 2,3-dimercapto-1-propanol complex of arsenite were potent, time-dependent, irreversible inhibitors of PEPCK.	arsenite	69-77	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	134-139
210844-1	1978	Inactivation of chicken liver xanthine dehydrogenase by arsenite is reflected in the molybdenum electron paramagnetic resonance signal at g = 1.97.	arsenite	56-64	xanthine dehydrogenase	Gallus gallus	30-52
33481270-4	2021	We found that in the livers of mice exposed to arsenite, there were elevated levels of microRNA-21 (miR-21), phosphorylated mammalian target of rapamycin (p-mTOR), and arginase 1 (Arg1); low levels of phosphatase and tensin homolog (PTEN); and more extensive liver fibrosis.	arsenite	47-55	microRNA 21a	Mus musculus	87-98
187503-0	1976	Turkey liver xanthine dehydrogenase: further observations on the reaction with arsenite.	arsenite	79-87	xanthine dehydrogenase/oxidase	Meleagris gallopavo	13-35
19036-0	1977	Effects of quaternary ligands on the inhibition of acetylcholinesterase by arsenite.	arsenite	75-83	acetylcholinesterase (Cartwright blood group)	Homo sapiens	51-71
19036-1	1977	Arsenite inhibits acetylcholinesterase in a second-order reaction.	arsenite	0-8	acetylcholinesterase (Cartwright blood group)	Homo sapiens	18-38
19036-5	1977	Although the kinetic data are consistent with a covalent reaction between arsenite and acetylcholinesterase, chemical evidence excludes the involvement of sulfhydryl groups which are usually implicated in arsenite inhibition.	arsenite	74-82	acetylcholinesterase (Cartwright blood group)	Homo sapiens	87-107
1265795-1	1976	In vitro conversion of 2-14C-mevalonate to cholest-5en-3 beta-ol (cholesterol) in rat liver homogenates is inhibited by arsenite, beta-mercaptoethanol, dithiothreitol and ethanethiol.	arsenite	120-128	integrin subunit beta 1	Rattus norvegicus	57-64
33481270-4	2021	We found that in the livers of mice exposed to arsenite, there were elevated levels of microRNA-21 (miR-21), phosphorylated mammalian target of rapamycin (p-mTOR), and arginase 1 (Arg1); low levels of phosphatase and tensin homolog (PTEN); and more extensive liver fibrosis.	arsenite	47-55	microRNA 21a	Mus musculus	100-106
33481270-4	2021	We found that in the livers of mice exposed to arsenite, there were elevated levels of microRNA-21 (miR-21), phosphorylated mammalian target of rapamycin (p-mTOR), and arginase 1 (Arg1); low levels of phosphatase and tensin homolog (PTEN); and more extensive liver fibrosis.	arsenite	47-55	mechanistic target of rapamycin kinase	Homo sapiens	124-153
33481270-4	2021	We found that in the livers of mice exposed to arsenite, there were elevated levels of microRNA-21 (miR-21), phosphorylated mammalian target of rapamycin (p-mTOR), and arginase 1 (Arg1); low levels of phosphatase and tensin homolog (PTEN); and more extensive liver fibrosis.	arsenite	47-55	mechanistic target of rapamycin kinase	Homo sapiens	157-161
33481270-4	2021	We found that in the livers of mice exposed to arsenite, there were elevated levels of microRNA-21 (miR-21), phosphorylated mammalian target of rapamycin (p-mTOR), and arginase 1 (Arg1); low levels of phosphatase and tensin homolog (PTEN); and more extensive liver fibrosis.	arsenite	47-55	arginase 1	Homo sapiens	168-178
33481270-4	2021	We found that in the livers of mice exposed to arsenite, there were elevated levels of microRNA-21 (miR-21), phosphorylated mammalian target of rapamycin (p-mTOR), and arginase 1 (Arg1); low levels of phosphatase and tensin homolog (PTEN); and more extensive liver fibrosis.	arsenite	47-55	arginase 1	Homo sapiens	180-184
33781819-0	2021	Targeting SLC1A5 blocks cell proliferation through inhibition of mTORC1 in arsenite-treated human uroepithelial cells.	arsenite	75-83	solute carrier family 1 (neutral amino acid transporter), member 5	Mus musculus	10-16
33781819-7	2021	This study characterized the role of SLC1A5 in cell proliferation in arsenite-treated cells.	arsenite	69-77	solute carrier family 1 (neutral amino acid transporter), member 5	Mus musculus	37-43
33781819-9	2021	In both short-term and long-term experiments, arsenite increased expression of SLC1A5 by 1.89-fold and 2.25-fold, respectively.	arsenite	46-54	solute carrier family 1 member 5	Homo sapiens	79-85
33781819-11	2021	Importantly, inhibiting SLC1A5 blocked cell proliferation by downregulating mTORC1 in long-term arsenite-treated cells.	arsenite	96-104	solute carrier family 1 (neutral amino acid transporter), member 5	Mus musculus	24-30
33781819-11	2021	Importantly, inhibiting SLC1A5 blocked cell proliferation by downregulating mTORC1 in long-term arsenite-treated cells.	arsenite	96-104	CREB regulated transcription coactivator 1	Mus musculus	76-82
33781819-13	2021	Our results suggest that SLC1A5 plays an important role in cell proliferation of arsenite-treated SV-HUC-1 cells.	arsenite	81-89	solute carrier family 1 (neutral amino acid transporter), member 5	Mus musculus	25-31
33781819-0	2021	Targeting SLC1A5 blocks cell proliferation through inhibition of mTORC1 in arsenite-treated human uroepithelial cells.	arsenite	75-83	CREB regulated transcription coactivator 1	Mus musculus	65-71
33881688-6	2021	In arsenite-treated worms, down-regulation of skn-1 significantly exacerbated the arsenite-induced changed expressions of oxidative damage-related genes, xbp-1, apl-1 and trxr-2, but these regulated effects of skn-1 were not observed on spr-4 and sel-12 expressions under arsenite treatment.	arsenite	82-90	Presenilin sel-12	Caenorhabditis elegans	247-253
33481270-4	2021	We found that in the livers of mice exposed to arsenite, there were elevated levels of microRNA-21 (miR-21), phosphorylated mammalian target of rapamycin (p-mTOR), and arginase 1 (Arg1); low levels of phosphatase and tensin homolog (PTEN); and more extensive liver fibrosis.	arsenite	47-55	phosphatase and tensin homolog	Homo sapiens	201-231
33881688-6	2021	In arsenite-treated worms, down-regulation of skn-1 significantly exacerbated the arsenite-induced changed expressions of oxidative damage-related genes, xbp-1, apl-1 and trxr-2, but these regulated effects of skn-1 were not observed on spr-4 and sel-12 expressions under arsenite treatment.	arsenite	82-90	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	46-51
33481270-4	2021	We found that in the livers of mice exposed to arsenite, there were elevated levels of microRNA-21 (miR-21), phosphorylated mammalian target of rapamycin (p-mTOR), and arginase 1 (Arg1); low levels of phosphatase and tensin homolog (PTEN); and more extensive liver fibrosis.	arsenite	47-55	phosphatase and tensin homolog	Homo sapiens	233-237
33481270-5	2021	For cultured cells, arsenite-induced miR-21, p-mTOR, and Arg1; decreased PTEN; and promoted M2 polarization of macrophages derived from THP-1 monocytes (THP-M), which caused secretion of fibrogenic cytokines, including transforming growth factor-beta1.	arsenite	20-28	microRNA 21	Homo sapiens	37-43
33881688-6	2021	In arsenite-treated worms, down-regulation of skn-1 significantly exacerbated the arsenite-induced changed expressions of oxidative damage-related genes, xbp-1, apl-1 and trxr-2, but these regulated effects of skn-1 were not observed on spr-4 and sel-12 expressions under arsenite treatment.	arsenite	82-90	BZIP domain-containing protein	Caenorhabditis elegans	154-159
33481270-5	2021	For cultured cells, arsenite-induced miR-21, p-mTOR, and Arg1; decreased PTEN; and promoted M2 polarization of macrophages derived from THP-1 monocytes (THP-M), which caused secretion of fibrogenic cytokines, including transforming growth factor-beta1.	arsenite	20-28	mechanistic target of rapamycin kinase	Homo sapiens	47-51
33881688-6	2021	In arsenite-treated worms, down-regulation of skn-1 significantly exacerbated the arsenite-induced changed expressions of oxidative damage-related genes, xbp-1, apl-1 and trxr-2, but these regulated effects of skn-1 were not observed on spr-4 and sel-12 expressions under arsenite treatment.	arsenite	82-90	Amyloid-beta-like protein	Caenorhabditis elegans	161-166
33481270-5	2021	For cultured cells, arsenite-induced miR-21, p-mTOR, and Arg1; decreased PTEN; and promoted M2 polarization of macrophages derived from THP-1 monocytes (THP-M), which caused secretion of fibrogenic cytokines, including transforming growth factor-beta1.	arsenite	20-28	arginase 1	Homo sapiens	57-61
33481270-5	2021	For cultured cells, arsenite-induced miR-21, p-mTOR, and Arg1; decreased PTEN; and promoted M2 polarization of macrophages derived from THP-1 monocytes (THP-M), which caused secretion of fibrogenic cytokines, including transforming growth factor-beta1.	arsenite	20-28	phosphatase and tensin homolog	Homo sapiens	73-77
33881688-6	2021	In arsenite-treated worms, down-regulation of skn-1 significantly exacerbated the arsenite-induced changed expressions of oxidative damage-related genes, xbp-1, apl-1 and trxr-2, but these regulated effects of skn-1 were not observed on spr-4 and sel-12 expressions under arsenite treatment.	arsenite	82-90	putative glutathione reductase 2	Caenorhabditis elegans	171-177
33481270-5	2021	For cultured cells, arsenite-induced miR-21, p-mTOR, and Arg1; decreased PTEN; and promoted M2 polarization of macrophages derived from THP-1 monocytes (THP-M), which caused secretion of fibrogenic cytokines, including transforming growth factor-beta1.	arsenite	20-28	GLI family zinc finger 2	Homo sapiens	136-141
33881688-6	2021	In arsenite-treated worms, down-regulation of skn-1 significantly exacerbated the arsenite-induced changed expressions of oxidative damage-related genes, xbp-1, apl-1 and trxr-2, but these regulated effects of skn-1 were not observed on spr-4 and sel-12 expressions under arsenite treatment.	arsenite	82-90	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	210-215
33481270-5	2021	For cultured cells, arsenite-induced miR-21, p-mTOR, and Arg1; decreased PTEN; and promoted M2 polarization of macrophages derived from THP-1 monocytes (THP-M), which caused secretion of fibrogenic cytokines, including transforming growth factor-beta1.	arsenite	20-28	transforming growth factor beta 1	Homo sapiens	219-251
33481270-6	2021	Coculture of arsenite-treated, THP-M with LX-2 cells induced alpha-SMA and collagen I in the LX-2 cells and resulted in the activation of these cells.	arsenite	13-21	actin alpha 1, skeletal muscle	Homo sapiens	61-70
33481270-7	2021	Downregulation of miR-21 in THP-M inhibited arsenite-induced M2 polarization and activation of LX-2 cells, but cotransfection with PTEN siRNA or a miR-21 inhibitor reversed this inhibition.	arsenite	44-52	microRNA 21	Homo sapiens	18-24
33481270-7	2021	Downregulation of miR-21 in THP-M inhibited arsenite-induced M2 polarization and activation of LX-2 cells, but cotransfection with PTEN siRNA or a miR-21 inhibitor reversed this inhibition.	arsenite	44-52	microRNA 21	Homo sapiens	147-153
33481270-8	2021	Moreover, knockout of miR-21 in mice attenuated liver fibrosis and M2 polarization compared with WT mice exposed to arsenite.	arsenite	116-124	microRNA 21a	Mus musculus	22-28
33481270-10	2021	Thus, arsenite induces the M2 polarization of macrophages via miR-21 regulation of PTEN, which is involved in the activation of hepatic stellate cells and hepatic fibrosis.	arsenite	6-14	microRNA 21	Homo sapiens	62-68
33481270-10	2021	Thus, arsenite induces the M2 polarization of macrophages via miR-21 regulation of PTEN, which is involved in the activation of hepatic stellate cells and hepatic fibrosis.	arsenite	6-14	phosphatase and tensin homolog	Homo sapiens	83-87
33881688-6	2021	In arsenite-treated worms, down-regulation of skn-1 significantly exacerbated the arsenite-induced changed expressions of oxidative damage-related genes, xbp-1, apl-1 and trxr-2, but these regulated effects of skn-1 were not observed on spr-4 and sel-12 expressions under arsenite treatment.	arsenite	82-90	Suppressor of presenilin protein 4	Caenorhabditis elegans	237-242
33881688-6	2021	In arsenite-treated worms, down-regulation of skn-1 significantly exacerbated the arsenite-induced changed expressions of oxidative damage-related genes, xbp-1, apl-1 and trxr-2, but these regulated effects of skn-1 were not observed on spr-4 and sel-12 expressions under arsenite treatment.	arsenite	82-90	Presenilin sel-12	Caenorhabditis elegans	247-253
33881688-7	2021	These findings together suggest that skn-1 may play a vital role in protection of C. elegans from arsenite-induced oxidative damage.	arsenite	98-106	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	37-42
33743404-0	2021	MicroRNA-191 blocking the translocation of GLUT4 is involved in arsenite-induced hepatic insulin resistance through inhibiting the IRS1/AKT pathway.	arsenite	64-72	solute carrier family 2 member 4	Homo sapiens	43-48
33743404-0	2021	MicroRNA-191 blocking the translocation of GLUT4 is involved in arsenite-induced hepatic insulin resistance through inhibiting the IRS1/AKT pathway.	arsenite	64-72	insulin receptor substrate 1	Homo sapiens	131-135
33881688-0	2021	Knock-down of transcription factor skinhead-1 exacerbates arsenite-induced oxidative damage in Caenorhabditis elegans.	arsenite	58-66	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	35-45
33743404-0	2021	MicroRNA-191 blocking the translocation of GLUT4 is involved in arsenite-induced hepatic insulin resistance through inhibiting the IRS1/AKT pathway.	arsenite	64-72	AKT serine/threonine kinase 1	Homo sapiens	136-139
33881688-4	2021	Thus, in this study, by using RNAi feeding, different toxic responses of wild-type and skn-1 knockdown nematodes to arsenite were evaluated.	arsenite	116-124	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	87-92
33743404-7	2021	Further, for livers of mice exposed to arsenite, miR-191 levels were higher, and protein levels of insulin receptor substrate 1 (IRS1), p-IRS1, and phospho-protein kinase B (p-AKT) were lower.	arsenite	39-47	microRNA 191	Mus musculus	49-56
33881688-5	2021	Our results demonstrated that arsenite did not show any significant impacts on locomotory behaviors, but skn-1 knock-down worms were much more sensitive to arsenite treatment, manifested by an aggravated reduction of survival rate than that of wild-type nematodes.	arsenite	156-164	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	105-110
33881688-6	2021	In arsenite-treated worms, down-regulation of skn-1 significantly exacerbated the arsenite-induced changed expressions of oxidative damage-related genes, xbp-1, apl-1 and trxr-2, but these regulated effects of skn-1 were not observed on spr-4 and sel-12 expressions under arsenite treatment.	arsenite	3-11	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	46-51
33743404-7	2021	Further, for livers of mice exposed to arsenite, miR-191 levels were higher, and protein levels of insulin receptor substrate 1 (IRS1), p-IRS1, and phospho-protein kinase B (p-AKT) were lower.	arsenite	39-47	insulin receptor substrate 1	Mus musculus	99-127
33881688-6	2021	In arsenite-treated worms, down-regulation of skn-1 significantly exacerbated the arsenite-induced changed expressions of oxidative damage-related genes, xbp-1, apl-1 and trxr-2, but these regulated effects of skn-1 were not observed on spr-4 and sel-12 expressions under arsenite treatment.	arsenite	82-90	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	46-51
33881688-6	2021	In arsenite-treated worms, down-regulation of skn-1 significantly exacerbated the arsenite-induced changed expressions of oxidative damage-related genes, xbp-1, apl-1 and trxr-2, but these regulated effects of skn-1 were not observed on spr-4 and sel-12 expressions under arsenite treatment.	arsenite	82-90	BZIP domain-containing protein	Caenorhabditis elegans	154-159
33743404-7	2021	Further, for livers of mice exposed to arsenite, miR-191 levels were higher, and protein levels of insulin receptor substrate 1 (IRS1), p-IRS1, and phospho-protein kinase B (p-AKT) were lower.	arsenite	39-47	insulin receptor substrate 1	Mus musculus	129-133
33881688-6	2021	In arsenite-treated worms, down-regulation of skn-1 significantly exacerbated the arsenite-induced changed expressions of oxidative damage-related genes, xbp-1, apl-1 and trxr-2, but these regulated effects of skn-1 were not observed on spr-4 and sel-12 expressions under arsenite treatment.	arsenite	82-90	Amyloid-beta-like protein	Caenorhabditis elegans	161-166
33743404-7	2021	Further, for livers of mice exposed to arsenite, miR-191 levels were higher, and protein levels of insulin receptor substrate 1 (IRS1), p-IRS1, and phospho-protein kinase B (p-AKT) were lower.	arsenite	39-47	insulin receptor substrate 1	Mus musculus	138-142
33881688-6	2021	In arsenite-treated worms, down-regulation of skn-1 significantly exacerbated the arsenite-induced changed expressions of oxidative damage-related genes, xbp-1, apl-1 and trxr-2, but these regulated effects of skn-1 were not observed on spr-4 and sel-12 expressions under arsenite treatment.	arsenite	82-90	putative glutathione reductase 2	Caenorhabditis elegans	171-177
33881688-6	2021	In arsenite-treated worms, down-regulation of skn-1 significantly exacerbated the arsenite-induced changed expressions of oxidative damage-related genes, xbp-1, apl-1 and trxr-2, but these regulated effects of skn-1 were not observed on spr-4 and sel-12 expressions under arsenite treatment.	arsenite	82-90	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	210-215
33743404-7	2021	Further, for livers of mice exposed to arsenite, miR-191 levels were higher, and protein levels of insulin receptor substrate 1 (IRS1), p-IRS1, and phospho-protein kinase B (p-AKT) were lower.	arsenite	39-47	thymoma viral proto-oncogene 1	Mus musculus	176-179
33881688-6	2021	In arsenite-treated worms, down-regulation of skn-1 significantly exacerbated the arsenite-induced changed expressions of oxidative damage-related genes, xbp-1, apl-1 and trxr-2, but these regulated effects of skn-1 were not observed on spr-4 and sel-12 expressions under arsenite treatment.	arsenite	82-90	Suppressor of presenilin protein 4	Caenorhabditis elegans	237-242
33743404-9	2021	For insulin-treated L-02 cells, arsenite decreased glucose consumption and glycogen levels, increased miR-191 levels, and inhibited the IRS1/AKT pathway and the translocation of GLUT4 from the cytoplasm to the plasma membrane.	arsenite	32-40	insulin	Homo sapiens	4-11
33743404-9	2021	For insulin-treated L-02 cells, arsenite decreased glucose consumption and glycogen levels, increased miR-191 levels, and inhibited the IRS1/AKT pathway and the translocation of GLUT4 from the cytoplasm to the plasma membrane.	arsenite	32-40	microRNA 191	Homo sapiens	102-109
33743404-9	2021	For insulin-treated L-02 cells, arsenite decreased glucose consumption and glycogen levels, increased miR-191 levels, and inhibited the IRS1/AKT pathway and the translocation of GLUT4 from the cytoplasm to the plasma membrane.	arsenite	32-40	insulin receptor substrate 1	Homo sapiens	136-140
33743404-9	2021	For insulin-treated L-02 cells, arsenite decreased glucose consumption and glycogen levels, increased miR-191 levels, and inhibited the IRS1/AKT pathway and the translocation of GLUT4 from the cytoplasm to the plasma membrane.	arsenite	32-40	AKT serine/threonine kinase 1	Homo sapiens	141-144
33743404-9	2021	For insulin-treated L-02 cells, arsenite decreased glucose consumption and glycogen levels, increased miR-191 levels, and inhibited the IRS1/AKT pathway and the translocation of GLUT4 from the cytoplasm to the plasma membrane.	arsenite	32-40	solute carrier family 2 member 4	Homo sapiens	178-183
33743404-10	2021	For insulin-treated L-02 cells, the decreases of glucose consumption, glycogen levels, GLUT4 on the plasma membrane, and p-AKT levels induced by arsenite were reversed by SC79 (agonist of AKT) and an miR-191 inhibitor; these effects caused by miR-191 inhibitor were restored by IRS1 siRNA.	arsenite	145-153	insulin	Homo sapiens	4-11
33743404-10	2021	For insulin-treated L-02 cells, the decreases of glucose consumption, glycogen levels, GLUT4 on the plasma membrane, and p-AKT levels induced by arsenite were reversed by SC79 (agonist of AKT) and an miR-191 inhibitor; these effects caused by miR-191 inhibitor were restored by IRS1 siRNA.	arsenite	145-153	solute carrier family 2 member 4	Homo sapiens	87-92
33743404-10	2021	For insulin-treated L-02 cells, the decreases of glucose consumption, glycogen levels, GLUT4 on the plasma membrane, and p-AKT levels induced by arsenite were reversed by SC79 (agonist of AKT) and an miR-191 inhibitor; these effects caused by miR-191 inhibitor were restored by IRS1 siRNA.	arsenite	145-153	AKT serine/threonine kinase 1	Homo sapiens	123-126
33743404-10	2021	For insulin-treated L-02 cells, the decreases of glucose consumption, glycogen levels, GLUT4 on the plasma membrane, and p-AKT levels induced by arsenite were reversed by SC79 (agonist of AKT) and an miR-191 inhibitor; these effects caused by miR-191 inhibitor were restored by IRS1 siRNA.	arsenite	145-153	AKT serine/threonine kinase 1	Homo sapiens	188-191
33743404-10	2021	For insulin-treated L-02 cells, the decreases of glucose consumption, glycogen levels, GLUT4 on the plasma membrane, and p-AKT levels induced by arsenite were reversed by SC79 (agonist of AKT) and an miR-191 inhibitor; these effects caused by miR-191 inhibitor were restored by IRS1 siRNA.	arsenite	145-153	microRNA 191	Homo sapiens	200-207
33743404-10	2021	For insulin-treated L-02 cells, the decreases of glucose consumption, glycogen levels, GLUT4 on the plasma membrane, and p-AKT levels induced by arsenite were reversed by SC79 (agonist of AKT) and an miR-191 inhibitor; these effects caused by miR-191 inhibitor were restored by IRS1 siRNA.	arsenite	145-153	microRNA 191	Homo sapiens	243-250
33743404-10	2021	For insulin-treated L-02 cells, the decreases of glucose consumption, glycogen levels, GLUT4 on the plasma membrane, and p-AKT levels induced by arsenite were reversed by SC79 (agonist of AKT) and an miR-191 inhibitor; these effects caused by miR-191 inhibitor were restored by IRS1 siRNA.	arsenite	145-153	insulin receptor substrate 1	Homo sapiens	278-282
33743404-11	2021	In insulin-treated L-02 cells, miR-191, via IRS1, was involved in the arsenite-induced decreases of glucose consumption and glycogen levels and in inhibition of the translocation of GLUT4.	arsenite	70-78	insulin	Homo sapiens	3-10
33743404-11	2021	In insulin-treated L-02 cells, miR-191, via IRS1, was involved in the arsenite-induced decreases of glucose consumption and glycogen levels and in inhibition of the translocation of GLUT4.	arsenite	70-78	microRNA 191	Homo sapiens	31-38
33743404-11	2021	In insulin-treated L-02 cells, miR-191, via IRS1, was involved in the arsenite-induced decreases of glucose consumption and glycogen levels and in inhibition of the translocation of GLUT4.	arsenite	70-78	insulin receptor substrate 1	Homo sapiens	44-48
33743404-11	2021	In insulin-treated L-02 cells, miR-191, via IRS1, was involved in the arsenite-induced decreases of glucose consumption and glycogen levels and in inhibition of the translocation of GLUT4.	arsenite	70-78	solute carrier family 2 member 4	Homo sapiens	182-187
33743404-12	2021	Thus, miR-191 blocking the translocation of GLUT4 was involved in arsenite-induced hepatic insulin resistance through inhibiting the IRS1/AKT pathway.	arsenite	66-74	microRNA 191	Homo sapiens	6-13
33743404-12	2021	Thus, miR-191 blocking the translocation of GLUT4 was involved in arsenite-induced hepatic insulin resistance through inhibiting the IRS1/AKT pathway.	arsenite	66-74	solute carrier family 2 member 4	Homo sapiens	44-49
33743404-12	2021	Thus, miR-191 blocking the translocation of GLUT4 was involved in arsenite-induced hepatic insulin resistance through inhibiting the IRS1/AKT pathway.	arsenite	66-74	insulin receptor substrate 1	Homo sapiens	133-137
33743404-12	2021	Thus, miR-191 blocking the translocation of GLUT4 was involved in arsenite-induced hepatic insulin resistance through inhibiting the IRS1/AKT pathway.	arsenite	66-74	AKT serine/threonine kinase 1	Homo sapiens	138-141
34048950-0	2021	Arsenite Provides A Selective Signal that Coordinates Arsenate Uptake and Detoxificacion Involving Regulation of PHR1 Stability in Arabidopsis thaliana.	arsenite	0-8	photolyase 1	Arabidopsis thaliana	113-117
34048950-6	2021	We also identified an arsenite responsive SKP1-like protein and a PHR1 interactor F-box (PHIF1) as constituents of the SCF complex responsible for PHR1 degradation.	arsenite	22-30	photolyase 1	Arabidopsis thaliana	147-151
34048950-7	2021	Furthermore, we found that arsenite, the form to which arsenate is reduced towards compartmentalization in vacuoles, represses PHT1;1 expression, providing a highly selective signal versus phosphate to control PHT1;1 expression in response to arsenate.	arsenite	27-35	phosphate transporter 1;1	Arabidopsis thaliana	127-133
34048950-7	2021	Furthermore, we found that arsenite, the form to which arsenate is reduced towards compartmentalization in vacuoles, represses PHT1;1 expression, providing a highly selective signal versus phosphate to control PHT1;1 expression in response to arsenate.	arsenite	27-35	phosphate transporter 1;1	Arabidopsis thaliana	210-216
33174204-0	2021	GBE attenuates arsenite-induced hepatotoxicity by regulating E2F1-autophagy-E2F7a pathway and restoring lysosomal activity.	arsenite	15-23	E2F transcription factor 1	Homo sapiens	61-65
34006163-12	2021	Additionally, arsenite-intoxication resulted in significant rise in hepatic parameters (serum aspartate aminotransferase, alanine transferase, alkaline phosphatase, and bilirubin (p < 0.001) along with multi-fold increase in oxidative stress, fibrosis and liver injury score in rats, which was significantly (p < 0.001) attenuated by concurrent administration of iNOS inhibitors).	arsenite	14-22	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	94-120
34006163-12	2021	Additionally, arsenite-intoxication resulted in significant rise in hepatic parameters (serum aspartate aminotransferase, alanine transferase, alkaline phosphatase, and bilirubin (p < 0.001) along with multi-fold increase in oxidative stress, fibrosis and liver injury score in rats, which was significantly (p < 0.001) attenuated by concurrent administration of iNOS inhibitors).	arsenite	14-22	nitric oxide synthase 2	Rattus norvegicus	363-367
33743404-0	2021	MicroRNA-191 blocking the translocation of GLUT4 is involved in arsenite-induced hepatic insulin resistance through inhibiting the IRS1/AKT pathway.	arsenite	64-72	microRNA 191	Homo sapiens	0-12
33545379-4	2021	In this study, we aimed to study the effects of Ngb knockdown in arsenite-treated rat neurons on levels of apoptosis markers and reactive oxygen species and serum Ngb levels of subjects from arsenic-endemic regions in China.	arsenite	65-73	neuroglobin	Rattus norvegicus	48-51
33545379-6	2021	Silencing of Ngb aggravated the arsenic-induced decrease in the rate of Bcl-2/Bax and the levels of Bcl-2 protein following arsenite treatment.	arsenite	124-132	neuroglobin	Rattus norvegicus	13-16
33545379-6	2021	Silencing of Ngb aggravated the arsenic-induced decrease in the rate of Bcl-2/Bax and the levels of Bcl-2 protein following arsenite treatment.	arsenite	124-132	BCL2, apoptosis regulator	Rattus norvegicus	100-105
33722599-6	2021	The results also showed that arsenite significantly decreased the expressions of ferritin and NCOA4, but sharply enhanced the level of autophagy marker LC3B, suggesting the activation of ferritinophagy by arsenite.	arsenite	29-37	nuclear receptor coactivator 4	Rattus norvegicus	94-99
33554343-8	2021	Further characterization of an amiRNA line targeting closely homologous CBF and ERF transcription factors show that the CBF1,2 and 3 transcription factors negatively regulate arsenite sensitivity.	arsenite	175-183	ETS2 repressor factor	Homo sapiens	80-83
33554343-8	2021	Further characterization of an amiRNA line targeting closely homologous CBF and ERF transcription factors show that the CBF1,2 and 3 transcription factors negatively regulate arsenite sensitivity.	arsenite	175-183	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	120-132
33554343-11	2021	These ERF transcription factors differentially regulate arsenite sensitivity and cadmium tolerance.	arsenite	56-64	ETS2 repressor factor	Homo sapiens	6-9
33965804-8	2021	For mice, chronic exposure to arsenite led to high levels of miR-21, AKT activation, elevated glycolysis, and pulmonary fibrosis; however, these effects were blocked by the depletion of miR-21 in miR-21 knockout (miR-21KO) mice.	arsenite	30-38	microRNA 21a	Mus musculus	61-67
33965804-8	2021	For mice, chronic exposure to arsenite led to high levels of miR-21, AKT activation, elevated glycolysis, and pulmonary fibrosis; however, these effects were blocked by the depletion of miR-21 in miR-21 knockout (miR-21KO) mice.	arsenite	30-38	thymoma viral proto-oncogene 1	Mus musculus	69-72
33965804-8	2021	For mice, chronic exposure to arsenite led to high levels of miR-21, AKT activation, elevated glycolysis, and pulmonary fibrosis; however, these effects were blocked by the depletion of miR-21 in miR-21 knockout (miR-21KO) mice.	arsenite	30-38	microRNA 21a	Mus musculus	186-192
33965804-8	2021	For mice, chronic exposure to arsenite led to high levels of miR-21, AKT activation, elevated glycolysis, and pulmonary fibrosis; however, these effects were blocked by the depletion of miR-21 in miR-21 knockout (miR-21KO) mice.	arsenite	30-38	microRNA 21a	Mus musculus	186-192
33965804-9	2021	After MRC-5 cells were co-cultured with arsenite-treated HBE cells, the levels of miR-21, AKT activation, glycolysis, and myofibroblast differentiation were enhanced, effects that were blocked by reducing miR-21 and by inhibiting the EVs in HBE cells.	arsenite	40-48	microRNA 21	Homo sapiens	82-88
33965804-9	2021	After MRC-5 cells were co-cultured with arsenite-treated HBE cells, the levels of miR-21, AKT activation, glycolysis, and myofibroblast differentiation were enhanced, effects that were blocked by reducing miR-21 and by inhibiting the EVs in HBE cells.	arsenite	40-48	AKT serine/threonine kinase 1	Homo sapiens	90-93
33965804-9	2021	After MRC-5 cells were co-cultured with arsenite-treated HBE cells, the levels of miR-21, AKT activation, glycolysis, and myofibroblast differentiation were enhanced, effects that were blocked by reducing miR-21 and by inhibiting the EVs in HBE cells.	arsenite	40-48	microRNA 21	Homo sapiens	205-211
33965804-11	2021	Thus, miR-21 down-regulates PTEN and promotes glycolysis via activating AKT, which is associated with arsenite-induced myofibroblast differentiation and pulmonary fibrosis.	arsenite	102-110	microRNA 21	Homo sapiens	6-12
33965804-11	2021	Thus, miR-21 down-regulates PTEN and promotes glycolysis via activating AKT, which is associated with arsenite-induced myofibroblast differentiation and pulmonary fibrosis.	arsenite	102-110	phosphatase and tensin homolog	Homo sapiens	28-32
33965804-11	2021	Thus, miR-21 down-regulates PTEN and promotes glycolysis via activating AKT, which is associated with arsenite-induced myofibroblast differentiation and pulmonary fibrosis.	arsenite	102-110	AKT serine/threonine kinase 1	Homo sapiens	72-75
33495037-1	2021	Photocatalytic oxidation of arsenite (As(III)) to arsenate (As(V)) was studied in aqueous solution using a series of WO3/TiO2 semiconductors readily synthesized through sol-gel method with WO3 content in the range of 1-5 wt%.	arsenite	28-36	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	59-65
33888601-6	2021	TSC2-deficient cells showed a striking increase in the number of SGs after thermal shock and arsenite treatment relative to Tsc2-expressing cells.	arsenite	93-101	TSC complex subunit 2	Mus musculus	0-4
33561751-4	2021	Previously, we observed that Arabidopsis PIP2;2, encoding a plasma membrane intrinsic protein, is highly expressed in NtCyc07-expressing Arabidopsis, which shows a higher tolerance to arsenite (As(III)).	arsenite	184-192	plasma membrane intrinsic protein 2	Arabidopsis thaliana	41-47
33706700-15	2021	Brain-derived neurotrophic factor (BDNF) and dopamine receptor D1a (Drd1a) gene expressions were significantly decreased (p < 0.05) only in the arsenite-F2 male mice of the 74-week-old group.	arsenite	144-152	brain derived neurotrophic factor	Mus musculus	0-33
33740714-1	2021	Arsenite (AsIII) antiporter ACR3 is crucial for arsenic (As) translocation and sequestration in As-hyperaccumulator Pteris vittata, which has potential for phytoremediation of As-contaminated soils.	arsenite	0-8	Arr3p	Saccharomyces cerevisiae S288C	28-32
33706700-15	2021	Brain-derived neurotrophic factor (BDNF) and dopamine receptor D1a (Drd1a) gene expressions were significantly decreased (p < 0.05) only in the arsenite-F2 male mice of the 74-week-old group.	arsenite	144-152	brain derived neurotrophic factor	Mus musculus	35-39
33706700-15	2021	Brain-derived neurotrophic factor (BDNF) and dopamine receptor D1a (Drd1a) gene expressions were significantly decreased (p < 0.05) only in the arsenite-F2 male mice of the 74-week-old group.	arsenite	144-152	dopamine receptor D1	Mus musculus	45-66
33706700-15	2021	Brain-derived neurotrophic factor (BDNF) and dopamine receptor D1a (Drd1a) gene expressions were significantly decreased (p < 0.05) only in the arsenite-F2 male mice of the 74-week-old group.	arsenite	144-152	dopamine receptor D1	Mus musculus	68-73
33706700-16	2021	Heme oxygenase-1 (HO-1) gene expression was significantly increased (p < 0.001) in the arsenite-F2 male mice of both groups, but plasma 8-hydroxy-2"-deoxyguanosine (8-OHdG) and cyclooxygenase-2 (COX-2) gene expression were not significantly different.	arsenite	87-95	heme oxygenase 1	Mus musculus	0-16
33687997-8	2021	Inhibition of the ubiquitin activating enzyme, deubiquitylating enzymes, the 26S proteasome and p97/VCP impaired the clearance of arsenite- and heat-induced SGs, whereas SGs induced by other stress conditions were little affected.	arsenite	130-138	valosin containing protein	Homo sapiens	96-99
33687997-8	2021	Inhibition of the ubiquitin activating enzyme, deubiquitylating enzymes, the 26S proteasome and p97/VCP impaired the clearance of arsenite- and heat-induced SGs, whereas SGs induced by other stress conditions were little affected.	arsenite	130-138	valosin containing protein	Homo sapiens	100-103
33706700-16	2021	Heme oxygenase-1 (HO-1) gene expression was significantly increased (p < 0.001) in the arsenite-F2 male mice of both groups, but plasma 8-hydroxy-2"-deoxyguanosine (8-OHdG) and cyclooxygenase-2 (COX-2) gene expression were not significantly different.	arsenite	87-95	heme oxygenase 1	Mus musculus	18-22
33706700-17	2021	Interleukin-1beta (IL-1beta) mRNA expression was significantly increased only in 41-week-old arsenite-F2 mice.	arsenite	93-101	interleukin 1 beta	Mus musculus	0-17
33706700-17	2021	Interleukin-1beta (IL-1beta) mRNA expression was significantly increased only in 41-week-old arsenite-F2 mice.	arsenite	93-101	interleukin 1 alpha	Mus musculus	19-27
33416861-7	2021	In response to oxidative cell stress induced by arsenite, SEPT9 localization to lysosomes is enhanced, promoting the perinuclear clustering of lysosomes.	arsenite	48-56	septin 9	Homo sapiens	58-63
33310519-0	2021	microRNA-21, via the HIF-1alpha/VEGF signaling pathway, is involved in arsenite-induced hepatic fibrosis through aberrant cross-talk of hepatocytes and hepatic stellate cells.	arsenite	71-79	microRNA 21	Homo sapiens	0-11
33310519-0	2021	microRNA-21, via the HIF-1alpha/VEGF signaling pathway, is involved in arsenite-induced hepatic fibrosis through aberrant cross-talk of hepatocytes and hepatic stellate cells.	arsenite	71-79	hypoxia inducible factor 1 subunit alpha	Homo sapiens	21-31
33310519-0	2021	microRNA-21, via the HIF-1alpha/VEGF signaling pathway, is involved in arsenite-induced hepatic fibrosis through aberrant cross-talk of hepatocytes and hepatic stellate cells.	arsenite	71-79	vascular endothelial growth factor A	Homo sapiens	32-36
33310519-2	2021	Mice exposed chronically to arsenite developed hepatic damage, inflammation, and fibrosis, as well as increased levels of microRNA-21 (miR-21) and hypoxia-inducible factor (HIF)-1alpha.	arsenite	28-36	microRNA 21a	Mus musculus	122-133
33310519-2	2021	Mice exposed chronically to arsenite developed hepatic damage, inflammation, and fibrosis, as well as increased levels of microRNA-21 (miR-21) and hypoxia-inducible factor (HIF)-1alpha.	arsenite	28-36	microRNA 21a	Mus musculus	135-141
33310519-2	2021	Mice exposed chronically to arsenite developed hepatic damage, inflammation, and fibrosis, as well as increased levels of microRNA-21 (miR-21) and hypoxia-inducible factor (HIF)-1alpha.	arsenite	28-36	hypoxia inducible factor 1, alpha subunit	Mus musculus	147-184
33310519-3	2021	The levels of miR-21 and HIF-1alpha were also enhanced in primary hepatocytes and L-02 cells exposed to arsenite.	arsenite	104-112	microRNA 21	Homo sapiens	14-20
33310519-3	2021	The levels of miR-21 and HIF-1alpha were also enhanced in primary hepatocytes and L-02 cells exposed to arsenite.	arsenite	104-112	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-35
33310519-5	2021	For L-02 cells, knockdown of miR-21 blocked the arsenite-induced up-regulation of HIF-1alpha and vascular endothelial growth factor (VEGF), which prevented the activation of LX-2 cells induced by medium from arsenite-exposed L-02 cells.	arsenite	48-56	microRNA 21	Homo sapiens	29-35
33310519-5	2021	For L-02 cells, knockdown of miR-21 blocked the arsenite-induced up-regulation of HIF-1alpha and vascular endothelial growth factor (VEGF), which prevented the activation of LX-2 cells induced by medium from arsenite-exposed L-02 cells.	arsenite	48-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-92
33310519-5	2021	For L-02 cells, knockdown of miR-21 blocked the arsenite-induced up-regulation of HIF-1alpha and vascular endothelial growth factor (VEGF), which prevented the activation of LX-2 cells induced by medium from arsenite-exposed L-02 cells.	arsenite	48-56	vascular endothelial growth factor A	Homo sapiens	97-131
33310519-5	2021	For L-02 cells, knockdown of miR-21 blocked the arsenite-induced up-regulation of HIF-1alpha and vascular endothelial growth factor (VEGF), which prevented the activation of LX-2 cells induced by medium from arsenite-exposed L-02 cells.	arsenite	48-56	vascular endothelial growth factor A	Homo sapiens	133-137
33310519-5	2021	For L-02 cells, knockdown of miR-21 blocked the arsenite-induced up-regulation of HIF-1alpha and vascular endothelial growth factor (VEGF), which prevented the activation of LX-2 cells induced by medium from arsenite-exposed L-02 cells.	arsenite	208-216	microRNA 21	Homo sapiens	29-35
33310519-5	2021	For L-02 cells, knockdown of miR-21 blocked the arsenite-induced up-regulation of HIF-1alpha and vascular endothelial growth factor (VEGF), which prevented the activation of LX-2 cells induced by medium from arsenite-exposed L-02 cells.	arsenite	208-216	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-92
33310519-5	2021	For L-02 cells, knockdown of miR-21 blocked the arsenite-induced up-regulation of HIF-1alpha and vascular endothelial growth factor (VEGF), which prevented the activation of LX-2 cells induced by medium from arsenite-exposed L-02 cells.	arsenite	208-216	vascular endothelial growth factor A	Homo sapiens	97-131
33310519-5	2021	For L-02 cells, knockdown of miR-21 blocked the arsenite-induced up-regulation of HIF-1alpha and vascular endothelial growth factor (VEGF), which prevented the activation of LX-2 cells induced by medium from arsenite-exposed L-02 cells.	arsenite	208-216	vascular endothelial growth factor A	Homo sapiens	133-137
33310519-7	2021	In arsenite-treated L-02 cells, miR-21 knockdown elevated the levels of ubiquitination and accelerated the degradation of HIF-1alpha via pVHL.	arsenite	3-11	microRNA 21	Homo sapiens	32-38
33310519-7	2021	In arsenite-treated L-02 cells, miR-21 knockdown elevated the levels of ubiquitination and accelerated the degradation of HIF-1alpha via pVHL.	arsenite	3-11	hypoxia inducible factor 1 subunit alpha	Homo sapiens	122-132
33310519-7	2021	In arsenite-treated L-02 cells, miR-21 knockdown elevated the levels of ubiquitination and accelerated the degradation of HIF-1alpha via pVHL.	arsenite	3-11	von Hippel-Lindau tumor suppressor	Homo sapiens	137-141
33310519-8	2021	In the livers of miR-21-/- mice exposed chronically to arsenite, there were less hepatic damage, lower fibrosis, lower levels of HIF-1alpha and VEGF, and higher levels of pVHL than for wild-type mice.	arsenite	55-63	microRNA 21a	Mus musculus	17-23
33310519-8	2021	In the livers of miR-21-/- mice exposed chronically to arsenite, there were less hepatic damage, lower fibrosis, lower levels of HIF-1alpha and VEGF, and higher levels of pVHL than for wild-type mice.	arsenite	55-63	hypoxia inducible factor 1, alpha subunit	Mus musculus	129-139
33310519-8	2021	In the livers of miR-21-/- mice exposed chronically to arsenite, there were less hepatic damage, lower fibrosis, lower levels of HIF-1alpha and VEGF, and higher levels of pVHL than for wild-type mice.	arsenite	55-63	vascular endothelial growth factor A	Mus musculus	144-148
33310519-8	2021	In the livers of miR-21-/- mice exposed chronically to arsenite, there were less hepatic damage, lower fibrosis, lower levels of HIF-1alpha and VEGF, and higher levels of pVHL than for wild-type mice.	arsenite	55-63	von Hippel-Lindau tumor suppressor	Mus musculus	171-175
33310519-9	2021	In summary, we propose that miR-21, acting via the HIF-1alpha/VEGF signaling pathway, is involved in arsenite-induced hepatic fibrosis through mediating aberrant cross-talk of hepatocytes and HSCs.	arsenite	101-109	microRNA 21a	Mus musculus	28-34
33386469-9	2021	Western blotting assays showed that the expression levels of EZH2 and cyclin-D1 proteins in arsenite-transformed cells increased.	arsenite	92-100	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	61-65
33386469-9	2021	Western blotting assays showed that the expression levels of EZH2 and cyclin-D1 proteins in arsenite-transformed cells increased.	arsenite	92-100	cyclin D1	Homo sapiens	70-79
33049506-4	2021	Inconsistent with dampened phosphorylation of immune-related proteins (nuclear factor kappa-B) NF-kappaB, p38 and JNK, the metalloid drastically induced the expression of Heme oxygenase-1 (HO-1) protein, which enlightened us to continuously explore the possible roles of HO-1 pathway in As-induced immune tolerance in BMDCs.	arsenite	287-289	heme oxygenase 1	Mus musculus	171-187
33049506-4	2021	Inconsistent with dampened phosphorylation of immune-related proteins (nuclear factor kappa-B) NF-kappaB, p38 and JNK, the metalloid drastically induced the expression of Heme oxygenase-1 (HO-1) protein, which enlightened us to continuously explore the possible roles of HO-1 pathway in As-induced immune tolerance in BMDCs.	arsenite	287-289	heme oxygenase 1	Mus musculus	189-193
33310519-9	2021	In summary, we propose that miR-21, acting via the HIF-1alpha/VEGF signaling pathway, is involved in arsenite-induced hepatic fibrosis through mediating aberrant cross-talk of hepatocytes and HSCs.	arsenite	101-109	hypoxia inducible factor 1, alpha subunit	Mus musculus	51-61
33310519-9	2021	In summary, we propose that miR-21, acting via the HIF-1alpha/VEGF signaling pathway, is involved in arsenite-induced hepatic fibrosis through mediating aberrant cross-talk of hepatocytes and HSCs.	arsenite	101-109	vascular endothelial growth factor A	Mus musculus	62-66
33261869-0	2021	Sustained high expression of NRF2 and its target genes induces dysregulation of cellular proliferation and apoptosis is associated with arsenite-induced malignant transformation of human bronchial epithelial cells.	arsenite	136-144	NFE2 like bZIP transcription factor 2	Homo sapiens	29-33
33261869-7	2021	This study demonstrated a novel role for the NRF2/NQO1 signaling pathway in mediating arsenite-induced cell transformation by increasing the expression of cyclin E-CDK2, and accelerating the cell cycle and cell proliferation.	arsenite	86-94	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
33261869-7	2021	This study demonstrated a novel role for the NRF2/NQO1 signaling pathway in mediating arsenite-induced cell transformation by increasing the expression of cyclin E-CDK2, and accelerating the cell cycle and cell proliferation.	arsenite	86-94	NAD(P)H quinone dehydrogenase 1	Homo sapiens	50-54
33261869-8	2021	Arsenite promotes activation of the NRF2/BCL-2 signaling pathway inhibited CHOP increasing cellular resistance to apoptosis and further promoting malignant transformation.	arsenite	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	36-40
33261869-8	2021	Arsenite promotes activation of the NRF2/BCL-2 signaling pathway inhibited CHOP increasing cellular resistance to apoptosis and further promoting malignant transformation.	arsenite	0-8	BCL2 apoptosis regulator	Homo sapiens	41-46
33261869-8	2021	Arsenite promotes activation of the NRF2/BCL-2 signaling pathway inhibited CHOP increasing cellular resistance to apoptosis and further promoting malignant transformation.	arsenite	0-8	DNA damage inducible transcript 3	Homo sapiens	75-79
33360347-6	2021	Chromatin immunoprecipitation analysis showed that the occupancy of Sp1 on the GDF1 or SIRT1 promoter was significantly reduced in response to arsenite.	arsenite	143-151	sirtuin 1	Danio rerio	87-92
33360347-8	2021	We found that expression of the oxidative adaptor p66shc was inversely related to that of SIRT1 and that the binding of SIRT1 to the p66shc promoter was sharply attenuated by arsenite treatment.	arsenite	175-183	sirtuin 1	Danio rerio	90-95
33360347-8	2021	We found that expression of the oxidative adaptor p66shc was inversely related to that of SIRT1 and that the binding of SIRT1 to the p66shc promoter was sharply attenuated by arsenite treatment.	arsenite	175-183	sirtuin 1	Danio rerio	120-125
33434570-4	2021	Our previous studies have proven that arsenite activates nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in hepatocytes.	arsenite	38-46	NFE2 like bZIP transcription factor 2	Homo sapiens	57-100
33434570-4	2021	Our previous studies have proven that arsenite activates nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in hepatocytes.	arsenite	38-46	NFE2 like bZIP transcription factor 2	Homo sapiens	102-106
33080309-0	2021	MicroRNA-15b in extracellular vesicles from arsenite-treated macrophages promotes the progression of hepatocellular carcinomas by blocking the LATS1-mediated Hippo pathway.	arsenite	44-52	microRNA 15b	Homo sapiens	0-12
33080309-0	2021	MicroRNA-15b in extracellular vesicles from arsenite-treated macrophages promotes the progression of hepatocellular carcinomas by blocking the LATS1-mediated Hippo pathway.	arsenite	44-52	large tumor suppressor kinase 1	Homo sapiens	143-148
33080309-8	2021	The results show that exposure to arsenite, increased miR-15b levels and induced M2 polarization of THP-1 cells.	arsenite	34-42	microRNA 15b	Homo sapiens	54-61
33080309-9	2021	Elevated levels of miR-15b were transferred from arsenite-treated-THP-1 (As-THP-1) cells to HCC cells via miR-15b in EVs inhibited activation of the Hippo pathway by targeting LATS1, and was involved in promoting the proliferation, migration, and invasion of HCC cells.	arsenite	49-57	microRNA 15b	Homo sapiens	19-26
33080309-9	2021	Elevated levels of miR-15b were transferred from arsenite-treated-THP-1 (As-THP-1) cells to HCC cells via miR-15b in EVs inhibited activation of the Hippo pathway by targeting LATS1, and was involved in promoting the proliferation, migration, and invasion of HCC cells.	arsenite	49-57	microRNA 15b	Homo sapiens	106-113
33080309-9	2021	Elevated levels of miR-15b were transferred from arsenite-treated-THP-1 (As-THP-1) cells to HCC cells via miR-15b in EVs inhibited activation of the Hippo pathway by targeting LATS1, and was involved in promoting the proliferation, migration, and invasion of HCC cells.	arsenite	49-57	large tumor suppressor kinase 1	Homo sapiens	176-181
33451022-0	2021	Arsenite Inhibits Tissue-Type Plasminogen Activator Synthesis through NRF2 Activation in Cultured Human Vascular Endothelial EA.hy926 Cells.	arsenite	0-8	plasminogen activator, tissue type	Homo sapiens	18-51
33451022-0	2021	Arsenite Inhibits Tissue-Type Plasminogen Activator Synthesis through NRF2 Activation in Cultured Human Vascular Endothelial EA.hy926 Cells.	arsenite	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	70-74
33451022-5	2021	We found that arsenite reduced fibrinolytic t-PA activity by inhibiting its synthesis without affecting PAI-1 production.	arsenite	14-22	plasminogen activator, tissue type	Homo sapiens	44-48
33451022-6	2021	The inhibitory effect of arsenite on t-PA expression was partially recovered by the reactive oxygen species (ROS) scavenger Trolox.	arsenite	25-33	plasminogen activator, tissue type	Homo sapiens	37-41
33451022-7	2021	The nuclear factor erythroid 2 related factor 2 (NRF2) pathway is known to be activated by arsenite via ROS production.	arsenite	91-99	NFE2 like bZIP transcription factor 2	Homo sapiens	4-47
33451022-7	2021	The nuclear factor erythroid 2 related factor 2 (NRF2) pathway is known to be activated by arsenite via ROS production.	arsenite	91-99	NFE2 like bZIP transcription factor 2	Homo sapiens	49-53
33451022-8	2021	We confirmed that arsenite activated the NRF2 pathway, and arsenite-induced inhibition of fibrinolytic t-PA activity was abrogated in NRF2-knockdown EA.hy926 cells.	arsenite	18-26	NFE2 like bZIP transcription factor 2	Homo sapiens	41-45
33451022-8	2021	We confirmed that arsenite activated the NRF2 pathway, and arsenite-induced inhibition of fibrinolytic t-PA activity was abrogated in NRF2-knockdown EA.hy926 cells.	arsenite	18-26	NFE2 like bZIP transcription factor 2	Homo sapiens	134-138
33451022-8	2021	We confirmed that arsenite activated the NRF2 pathway, and arsenite-induced inhibition of fibrinolytic t-PA activity was abrogated in NRF2-knockdown EA.hy926 cells.	arsenite	59-67	plasminogen activator, tissue type	Homo sapiens	103-107
33451022-8	2021	We confirmed that arsenite activated the NRF2 pathway, and arsenite-induced inhibition of fibrinolytic t-PA activity was abrogated in NRF2-knockdown EA.hy926 cells.	arsenite	59-67	NFE2 like bZIP transcription factor 2	Homo sapiens	134-138
33451022-9	2021	These results suggest that arsenite inhibits the fibrinolytic activity of t-PA by selectively suppressing its synthesis via activation of the NRF2 pathway in vascular endothelial cells.	arsenite	27-35	plasminogen activator, tissue type	Homo sapiens	74-78
33451022-9	2021	These results suggest that arsenite inhibits the fibrinolytic activity of t-PA by selectively suppressing its synthesis via activation of the NRF2 pathway in vascular endothelial cells.	arsenite	27-35	NFE2 like bZIP transcription factor 2	Homo sapiens	142-146
32827688-8	2020	Upon removal of arsenite, the recovery from chronic stress was complete for SG and P-TDP-43 aggregates at 72 h with the exception of p62, which was reduced but still persistent, supporting the hypothesis that autophagy impairment may drive pathological TDP-43 aggregates formation.	arsenite	16-24	TAR DNA binding protein	Homo sapiens	85-91
33279514-2	2021	Previous studies from our lab show that early developing T cells in the thymus are very sensitive to arsenite (As+3)-induced genotoxicity mediated through PARP-1 inhibition.	arsenite	101-109	poly (ADP-ribose) polymerase family, member 1	Mus musculus	155-161
33097607-1	2020	In our previous report, we demonstrated that one of the catalytic subunits of the I-kappaB kinase (IKK) complex, IKKalpha, performs an NF-kappaB-independent cytoprotective role in human hepatoma cells under the treatment of the anti-tumor therapeutic reagent arsenite.	arsenite	259-267	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	99-102
33097607-1	2020	In our previous report, we demonstrated that one of the catalytic subunits of the I-kappaB kinase (IKK) complex, IKKalpha, performs an NF-kappaB-independent cytoprotective role in human hepatoma cells under the treatment of the anti-tumor therapeutic reagent arsenite.	arsenite	259-267	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	113-121
33097607-2	2020	IKKalpha triggers its own feedback degradation by activating p53-dependent autophagy and therefore contributes largely to hepatoma cell apoptosis induced by arsenite.	arsenite	157-165	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	0-8
33097607-6	2020	Therefore, taken together with the previous report, we conclude that both IKKalpha- and CHK1-dependent p53 phosphorylation and acetylation contribute to mediating selective autophagy targeting feedback degradation of IKKalpha in arsenite-induced proapoptotic responses.	arsenite	229-237	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	74-82
33097607-6	2020	Therefore, taken together with the previous report, we conclude that both IKKalpha- and CHK1-dependent p53 phosphorylation and acetylation contribute to mediating selective autophagy targeting feedback degradation of IKKalpha in arsenite-induced proapoptotic responses.	arsenite	229-237	checkpoint kinase 1	Homo sapiens	88-92
33097607-6	2020	Therefore, taken together with the previous report, we conclude that both IKKalpha- and CHK1-dependent p53 phosphorylation and acetylation contribute to mediating selective autophagy targeting feedback degradation of IKKalpha in arsenite-induced proapoptotic responses.	arsenite	229-237	tumor protein p53	Homo sapiens	103-106
33097607-6	2020	Therefore, taken together with the previous report, we conclude that both IKKalpha- and CHK1-dependent p53 phosphorylation and acetylation contribute to mediating selective autophagy targeting feedback degradation of IKKalpha in arsenite-induced proapoptotic responses.	arsenite	229-237	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	217-225
32980394-3	2020	In the present study, we investigated the role of nuclear factor erythroid 2-related factor (NRF) 1 (NRF1), a sister member of the well-known master regulator in antioxidative response NRF2, in arsenite-induced cytotoxicity in mouse bone marrow-derived MSCs (mBM-MSCs).	arsenite	194-202	nuclear respiratory factor 1	Mus musculus	101-105
32980394-5	2020	Though short-isoform NRF1 (S-NRF1) was induced by arsenite at mRNA level, its protein level was not obviously altered.	arsenite	50-58	nuclear respiratory factor 1	Mus musculus	21-25
32980394-6	2020	Silencing L-Nrf1 sensitized the cells to arsenite-induced cytotoxicity.	arsenite	41-49	nuclear respiratory factor 1	Mus musculus	12-16
32980394-7	2020	L-Nrf1-silenced mBM-MSCs showed decreased arsenic efflux with reduced expression of arsenic transporter ATP-binding cassette subfamily C member 4 (ABCC4), as well as compromised NRF2-mediated antioxidative defense with elevated level of mitochondrial reactive oxygen species (mtROS) under arsenite-exposed conditions.	arsenite	289-297	nuclear respiratory factor 1	Mus musculus	2-6
32980394-8	2020	A specific mtROS scavenger (Mito-quinone) alleviated cell apoptosis induced by arsenite in L-Nrf1-silenced mBM-MSCs.	arsenite	79-87	nuclear respiratory factor 1	Mus musculus	93-97
32980394-9	2020	Taken together, these findings suggest that L-NRF1 protects mBM-MSCs from arsenite-induced cytotoxicity via suppressing mtROS in addition to facilitating cellular arsenic efflux.	arsenite	74-82	nuclear respiratory factor 1	Mus musculus	46-50
33162208-5	2021	We have found that, in lung tissues of mice, arsenite, a biologically active form of arsenic, elevated H19, c-Myc, and Arg1; decreased let-7a; and caused pulmonary fibrosis.	arsenite	45-53	H19, imprinted maternally expressed transcript	Mus musculus	103-106
33162208-5	2021	We have found that, in lung tissues of mice, arsenite, a biologically active form of arsenic, elevated H19, c-Myc, and Arg1; decreased let-7a; and caused pulmonary fibrosis.	arsenite	45-53	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	108-113
33162208-5	2021	We have found that, in lung tissues of mice, arsenite, a biologically active form of arsenic, elevated H19, c-Myc, and Arg1; decreased let-7a; and caused pulmonary fibrosis.	arsenite	45-53	arginase, liver	Mus musculus	119-123
33162208-5	2021	We have found that, in lung tissues of mice, arsenite, a biologically active form of arsenic, elevated H19, c-Myc, and Arg1; decreased let-7a; and caused pulmonary fibrosis.	arsenite	45-53	microRNA let7a-1	Mus musculus	135-141
33162208-6	2021	For THP-1 macrophages (THP-M) and bone-marrow-derived macrophages (BMDMs), 8 muM arsenite increased H19, c-Myc, and Arg1; decreased let-7a; and induced M2 polarization of macrophages, which caused secretion of the fibrogenic cytokine, TGF-beta1.	arsenite	81-89	GLI family zinc finger 2	Homo sapiens	4-9
33162208-6	2021	For THP-1 macrophages (THP-M) and bone-marrow-derived macrophages (BMDMs), 8 muM arsenite increased H19, c-Myc, and Arg1; decreased let-7a; and induced M2 polarization of macrophages, which caused secretion of the fibrogenic cytokine, TGF-beta1.	arsenite	81-89	H19, imprinted maternally expressed transcript	Mus musculus	100-103
33162208-6	2021	For THP-1 macrophages (THP-M) and bone-marrow-derived macrophages (BMDMs), 8 muM arsenite increased H19, c-Myc, and Arg1; decreased let-7a; and induced M2 polarization of macrophages, which caused secretion of the fibrogenic cytokine, TGF-beta1.	arsenite	81-89	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	105-110
33162208-6	2021	For THP-1 macrophages (THP-M) and bone-marrow-derived macrophages (BMDMs), 8 muM arsenite increased H19, c-Myc, and Arg1; decreased let-7a; and induced M2 polarization of macrophages, which caused secretion of the fibrogenic cytokine, TGF-beta1.	arsenite	81-89	arginase, liver	Mus musculus	116-120
33162208-6	2021	For THP-1 macrophages (THP-M) and bone-marrow-derived macrophages (BMDMs), 8 muM arsenite increased H19, c-Myc, and Arg1; decreased let-7a; and induced M2 polarization of macrophages, which caused secretion of the fibrogenic cytokine, TGF-beta1.	arsenite	81-89	microRNA let7a-1	Mus musculus	132-138
33162208-6	2021	For THP-1 macrophages (THP-M) and bone-marrow-derived macrophages (BMDMs), 8 muM arsenite increased H19, c-Myc, and Arg1; decreased let-7a; and induced M2 polarization of macrophages, which caused secretion of the fibrogenic cytokine, TGF-beta1.	arsenite	81-89	transforming growth factor beta 1	Homo sapiens	235-244
33162208-7	2021	Down-regulation of H19 or up-regulation of let-7a reversed the arsenite-induced M2 polarization of macrophages.	arsenite	63-71	H19, imprinted maternally expressed transcript	Mus musculus	19-22
33162208-7	2021	Down-regulation of H19 or up-regulation of let-7a reversed the arsenite-induced M2 polarization of macrophages.	arsenite	63-71	microRNA let7a-1	Mus musculus	43-49
33162208-8	2021	Arsenite-treated THP-M and BMDMs co-cultured with MRC-5 cells or primary lung fibroblasts (PLFs) elevated levels of p-SMAD2/3, SMAD4, alpha-SMA, and collagen I in lung fibroblasts and resulted in the activation of lung fibroblasts.	arsenite	0-8	SMAD family member 2	Homo sapiens	118-125
33162208-8	2021	Arsenite-treated THP-M and BMDMs co-cultured with MRC-5 cells or primary lung fibroblasts (PLFs) elevated levels of p-SMAD2/3, SMAD4, alpha-SMA, and collagen I in lung fibroblasts and resulted in the activation of lung fibroblasts.	arsenite	0-8	SMAD family member 4	Homo sapiens	127-132
33162208-8	2021	Arsenite-treated THP-M and BMDMs co-cultured with MRC-5 cells or primary lung fibroblasts (PLFs) elevated levels of p-SMAD2/3, SMAD4, alpha-SMA, and collagen I in lung fibroblasts and resulted in the activation of lung fibroblasts.	arsenite	0-8	actin alpha 1, skeletal muscle	Homo sapiens	134-143
33162208-10	2021	The results indicated that H19 functioned as an miRNA sponge for let-7a, which was involved in arsenite-induced M2 polarization of macrophages and induced the myofibroblast differentiation phenotype by regulation of c-Myc.	arsenite	95-103	H19 imprinted maternally expressed transcript	Homo sapiens	27-30
33162208-10	2021	The results indicated that H19 functioned as an miRNA sponge for let-7a, which was involved in arsenite-induced M2 polarization of macrophages and induced the myofibroblast differentiation phenotype by regulation of c-Myc.	arsenite	95-103	microRNA let7a-1	Mus musculus	65-71
33162208-10	2021	The results indicated that H19 functioned as an miRNA sponge for let-7a, which was involved in arsenite-induced M2 polarization of macrophages and induced the myofibroblast differentiation phenotype by regulation of c-Myc.	arsenite	95-103	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	216-221
32735129-0	2021	Arsenite induces dysfunction of regulatory T cells through acetylation control of the Foxp3 promoter.	arsenite	0-8	forkhead box P3	Homo sapiens	86-91
33156617-2	2020	In humans and other eukaryotic organisms, the arsenite methyltransferase (AS3MT) protein methylates arsenite.	arsenite	46-54	arsenite methyltransferase	Homo sapiens	74-79
33425986-4	2020	Distinct from stressors such as arsenite that activates Hog1 via inhibiting its phosphatases, activation of Hog1 by MMS is phosphatase-independent.	arsenite	32-40	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	56-60
32991915-7	2020	Furthermore, chronic exposure to arsenite led to lower H2A ubiquitination (ubH2A); histone H3 acetylation K18 (H3AcK18); and histone H4 acetylations K5, K8, K12, and K16 (H4tetraAck) in haploid spermatids from testicular tissues.	arsenite	33-41	keratin 18	Mus musculus	106-109
32991915-7	2020	Furthermore, chronic exposure to arsenite led to lower H2A ubiquitination (ubH2A); histone H3 acetylation K18 (H3AcK18); and histone H4 acetylations K5, K8, K12, and K16 (H4tetraAck) in haploid spermatids from testicular tissues.	arsenite	33-41	keratin 12	Mus musculus	157-160
32991915-7	2020	Furthermore, chronic exposure to arsenite led to lower H2A ubiquitination (ubH2A); histone H3 acetylation K18 (H3AcK18); and histone H4 acetylations K5, K8, K12, and K16 (H4tetraAck) in haploid spermatids from testicular tissues.	arsenite	33-41	keratin 16	Mus musculus	166-169
33010264-5	2020	Gestational arsenite exposure enhanced the expression of p16, p21 and Mmp14 in F1 and p15 and Cxcl1 in F2, respectively.	arsenite	12-20	cyclin dependent kinase inhibitor 2A	Mus musculus	57-60
33010264-5	2020	Gestational arsenite exposure enhanced the expression of p16, p21 and Mmp14 in F1 and p15 and Cxcl1 in F2, respectively.	arsenite	12-20	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	62-65
33010264-5	2020	Gestational arsenite exposure enhanced the expression of p16, p21 and Mmp14 in F1 and p15 and Cxcl1 in F2, respectively.	arsenite	12-20	matrix metallopeptidase 14 (membrane-inserted)	Mus musculus	70-75
33010264-5	2020	Gestational arsenite exposure enhanced the expression of p16, p21 and Mmp14 in F1 and p15 and Cxcl1 in F2, respectively.	arsenite	12-20	cyclin dependent kinase inhibitor 2B	Mus musculus	86-89
33010264-5	2020	Gestational arsenite exposure enhanced the expression of p16, p21 and Mmp14 in F1 and p15 and Cxcl1 in F2, respectively.	arsenite	12-20	chemokine (C-X-C motif) ligand 1	Mus musculus	94-99
33010264-6	2020	Exploring the mechanisms by which arsenite exposure promotes cellular senescence, we found that the expression of antioxidant enzymes (Sod1 and Cat) were reduced in the tumors of F1 in the arsenite group, and Tgf-beta and the receptors of Tgf-beta were increased in the tumors of F2 in the arsenite group.	arsenite	34-42	superoxide dismutase 1, soluble	Mus musculus	135-139
33010264-6	2020	Exploring the mechanisms by which arsenite exposure promotes cellular senescence, we found that the expression of antioxidant enzymes (Sod1 and Cat) were reduced in the tumors of F1 in the arsenite group, and Tgf-beta and the receptors of Tgf-beta were increased in the tumors of F2 in the arsenite group.	arsenite	34-42	catalase	Mus musculus	144-147
33010264-6	2020	Exploring the mechanisms by which arsenite exposure promotes cellular senescence, we found that the expression of antioxidant enzymes (Sod1 and Cat) were reduced in the tumors of F1 in the arsenite group, and Tgf-beta and the receptors of Tgf-beta were increased in the tumors of F2 in the arsenite group.	arsenite	34-42	transforming growth factor alpha	Mus musculus	209-217
33010264-6	2020	Exploring the mechanisms by which arsenite exposure promotes cellular senescence, we found that the expression of antioxidant enzymes (Sod1 and Cat) were reduced in the tumors of F1 in the arsenite group, and Tgf-beta and the receptors of Tgf-beta were increased in the tumors of F2 in the arsenite group.	arsenite	34-42	transforming growth factor alpha	Mus musculus	239-247
33010264-6	2020	Exploring the mechanisms by which arsenite exposure promotes cellular senescence, we found that the expression of antioxidant enzymes (Sod1 and Cat) were reduced in the tumors of F1 in the arsenite group, and Tgf-beta and the receptors of Tgf-beta were increased in the tumors of F2 in the arsenite group.	arsenite	189-197	superoxide dismutase 1, soluble	Mus musculus	135-139
33010264-6	2020	Exploring the mechanisms by which arsenite exposure promotes cellular senescence, we found that the expression of antioxidant enzymes (Sod1 and Cat) were reduced in the tumors of F1 in the arsenite group, and Tgf-beta and the receptors of Tgf-beta were increased in the tumors of F2 in the arsenite group.	arsenite	189-197	catalase	Mus musculus	144-147
33010264-6	2020	Exploring the mechanisms by which arsenite exposure promotes cellular senescence, we found that the expression of antioxidant enzymes (Sod1 and Cat) were reduced in the tumors of F1 in the arsenite group, and Tgf-beta and the receptors of Tgf-beta were increased in the tumors of F2 in the arsenite group.	arsenite	189-197	transforming growth factor alpha	Mus musculus	239-247
33010264-6	2020	Exploring the mechanisms by which arsenite exposure promotes cellular senescence, we found that the expression of antioxidant enzymes (Sod1 and Cat) were reduced in the tumors of F1 in the arsenite group, and Tgf-beta and the receptors of Tgf-beta were increased in the tumors of F2 in the arsenite group.	arsenite	189-197	superoxide dismutase 1, soluble	Mus musculus	135-139
33010264-6	2020	Exploring the mechanisms by which arsenite exposure promotes cellular senescence, we found that the expression of antioxidant enzymes (Sod1 and Cat) were reduced in the tumors of F1 in the arsenite group, and Tgf-beta and the receptors of Tgf-beta were increased in the tumors of F2 in the arsenite group.	arsenite	189-197	catalase	Mus musculus	144-147
33010264-6	2020	Exploring the mechanisms by which arsenite exposure promotes cellular senescence, we found that the expression of antioxidant enzymes (Sod1 and Cat) were reduced in the tumors of F1 in the arsenite group, and Tgf-beta and the receptors of Tgf-beta were increased in the tumors of F2 in the arsenite group.	arsenite	189-197	transforming growth factor alpha	Mus musculus	239-247
33010264-8	2020	These results suggest that cellular senescence and SASP have important roles in hepatic tumorigenesis in C3H mice as well as HCC in humans, and gestational arsenite exposure of C3H mice enhances senescence in F1 and F2 via oxidative stress and Tgf-beta activation, respectively.	arsenite	156-164	transforming growth factor alpha	Mus musculus	244-252
33053406-0	2020	Activation of Lrrk2 and alpha-Synuclein in substantia nigra, striatum, and cerebellum after chronic exposure to arsenite.	arsenite	112-120	leucine-rich repeat kinase 2	Mus musculus	14-19
33053406-0	2020	Activation of Lrrk2 and alpha-Synuclein in substantia nigra, striatum, and cerebellum after chronic exposure to arsenite.	arsenite	112-120	synuclein, alpha	Mus musculus	24-39
33053406-2	2020	Considering that arsenic has the potential to inhibit autophagic flux, it was hypothesized that arsenite (NaAsO2) may interplay with LRRK2 and alpha-Synuclein, affecting their phosphorylation in brain regions prone to neurodegeneration.	arsenite	96-104	leucine-rich repeat kinase 2	Mus musculus	133-138
33053406-2	2020	Considering that arsenic has the potential to inhibit autophagic flux, it was hypothesized that arsenite (NaAsO2) may interplay with LRRK2 and alpha-Synuclein, affecting their phosphorylation in brain regions prone to neurodegeneration.	arsenite	96-104	synuclein, alpha	Mus musculus	143-158
33053406-4	2020	Thirty minutes exposure to arsenite increased phosphorylation of Lrrk2 and alpha-Synuclein in organotypic brain slice cultures from the cerebellum and striatum, respectively.	arsenite	27-35	leucine-rich repeat kinase 2	Mus musculus	65-70
33053406-4	2020	Thirty minutes exposure to arsenite increased phosphorylation of Lrrk2 and alpha-Synuclein in organotypic brain slice cultures from the cerebellum and striatum, respectively.	arsenite	27-35	synuclein, alpha	Mus musculus	75-90
33053406-5	2020	Chronic exposure of mice to a wide-range of concentrations of arsenite led to a significant induction of Lrrk2 phosphorylation in substantia nigra and cerebellum and alpha-Synuclein phosphorylation in substantia nigra and striatum.	arsenite	62-70	leucine-rich repeat kinase 2	Mus musculus	105-110
33053406-5	2020	Chronic exposure of mice to a wide-range of concentrations of arsenite led to a significant induction of Lrrk2 phosphorylation in substantia nigra and cerebellum and alpha-Synuclein phosphorylation in substantia nigra and striatum.	arsenite	62-70	synuclein, alpha	Mus musculus	166-181
33053406-8	2020	Chronic arsenite exposure altered transcripts of glutathione redox reactions and serotonin receptor signaling in striatum, axonal guidance signaling, NF-kappaB and androgen signaling in substantia nigra and mitochondrial dysfunction, oxidative phosphorylation, apoptosis and sirtuin signaling in the cerebellum.	arsenite	8-16	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	150-159
32980394-3	2020	In the present study, we investigated the role of nuclear factor erythroid 2-related factor (NRF) 1 (NRF1), a sister member of the well-known master regulator in antioxidative response NRF2, in arsenite-induced cytotoxicity in mouse bone marrow-derived MSCs (mBM-MSCs).	arsenite	194-202	nuclear respiratory factor 1	Mus musculus	50-99
33153165-0	2020	Mechanism for Higher Tolerance to and Lower Accumulation of Arsenite in NtCyc07-Overexpressing Tobacco.	arsenite	60-68	40S ribosomal protein S3a	Nicotiana tabacum	72-79
32866568-4	2020	Arsenite stimulated an oxidative stress response as detected by Nrf-2 nuclear accumulation and induction of HMOX-1 and NQO1, which was not detected with up to 30 muM uranyl acetate.	arsenite	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	64-69
32736004-3	2020	Arsenite treatment did not affect the gene expression of the main enzyme catalyzing methylation of arsenite, As3mt, while it reduced the expression of GSTO1 mRNA and protein.	arsenite	0-8	glutathione S-transferase omega 1	Rattus norvegicus	151-156
32736004-4	2020	Arsenite decreased the expression of Aqp3, Mrp1, Mrp4, and Mdr1b (i.e., transporters and channels used by arsenic), but not that of Aqp7, Glut1, Mrp2, and Mdr1a.	arsenite	0-8	aquaporin 3 (Gill blood group)	Rattus norvegicus	37-41
32736004-4	2020	Arsenite decreased the expression of Aqp3, Mrp1, Mrp4, and Mdr1b (i.e., transporters and channels used by arsenic), but not that of Aqp7, Glut1, Mrp2, and Mdr1a.	arsenite	0-8	ATP binding cassette subfamily C member 1	Rattus norvegicus	43-47
32866568-4	2020	Arsenite stimulated an oxidative stress response as detected by Nrf-2 nuclear accumulation and induction of HMOX-1 and NQO1, which was not detected with up to 30 muM uranyl acetate.	arsenite	0-8	heme oxygenase 1	Homo sapiens	108-114
32736004-4	2020	Arsenite decreased the expression of Aqp3, Mrp1, Mrp4, and Mdr1b (i.e., transporters and channels used by arsenic), but not that of Aqp7, Glut1, Mrp2, and Mdr1a.	arsenite	0-8	ATP binding cassette subfamily C member 4	Rattus norvegicus	49-53
32736004-4	2020	Arsenite decreased the expression of Aqp3, Mrp1, Mrp4, and Mdr1b (i.e., transporters and channels used by arsenic), but not that of Aqp7, Glut1, Mrp2, and Mdr1a.	arsenite	0-8	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	59-64
32866568-4	2020	Arsenite stimulated an oxidative stress response as detected by Nrf-2 nuclear accumulation and induction of HMOX-1 and NQO1, which was not detected with up to 30 muM uranyl acetate.	arsenite	0-8	NAD(P)H quinone dehydrogenase 1	Homo sapiens	119-123
32683294-0	2020	Arsenite-induced downregulation of occludin in mouse lungs and BEAS-2B cells via the ROS/ERK/ELK1/MLCK and ROS/p38 MAPK signaling pathways.	arsenite	0-8	occludin	Mus musculus	35-43
32736004-4	2020	Arsenite decreased the expression of Aqp3, Mrp1, Mrp4, and Mdr1b (i.e., transporters and channels used by arsenic), but not that of Aqp7, Glut1, Mrp2, and Mdr1a.	arsenite	0-8	ATP binding cassette subfamily B member 1A	Rattus norvegicus	155-160
32736004-5	2020	The protein abundance of AQP3 was also reduced by arsenite.	arsenite	50-58	aquaporin 3 (Gill blood group)	Rattus norvegicus	25-29
32736004-6	2020	Arsenite increased urinary NGAL and FABP3 and decreased Klotho plasma levels, without alteration of creatinine, which evidenced early tubular damage.	arsenite	0-8	lipocalin 2	Rattus norvegicus	27-31
32736004-6	2020	Arsenite increased urinary NGAL and FABP3 and decreased Klotho plasma levels, without alteration of creatinine, which evidenced early tubular damage.	arsenite	0-8	fatty acid binding protein 3	Rattus norvegicus	36-41
32736004-6	2020	Arsenite increased urinary NGAL and FABP3 and decreased Klotho plasma levels, without alteration of creatinine, which evidenced early tubular damage.	arsenite	0-8	Klotho	Rattus norvegicus	56-62
32736004-9	2020	Plasma PTH and FGF23 were similar between groups, but arsenite decreased the renal expression of Fgfr1 mRNA.	arsenite	54-62	Fibroblast growth factor receptor 1	Rattus norvegicus	97-102
32506763-0	2020	ROS-mediated PERK-eIF2alpha-ATF4 pathway plays an important role in arsenite-induced L-02 cells apoptosis via regulating CHOP-DR5 signaling.	arsenite	68-76	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	13-17
32506763-0	2020	ROS-mediated PERK-eIF2alpha-ATF4 pathway plays an important role in arsenite-induced L-02 cells apoptosis via regulating CHOP-DR5 signaling.	arsenite	68-76	eukaryotic translation initiation factor 2A	Homo sapiens	18-27
32506763-0	2020	ROS-mediated PERK-eIF2alpha-ATF4 pathway plays an important role in arsenite-induced L-02 cells apoptosis via regulating CHOP-DR5 signaling.	arsenite	68-76	activating transcription factor 4	Homo sapiens	28-32
32506763-0	2020	ROS-mediated PERK-eIF2alpha-ATF4 pathway plays an important role in arsenite-induced L-02 cells apoptosis via regulating CHOP-DR5 signaling.	arsenite	68-76	DNA damage inducible transcript 3	Homo sapiens	121-125
32506763-0	2020	ROS-mediated PERK-eIF2alpha-ATF4 pathway plays an important role in arsenite-induced L-02 cells apoptosis via regulating CHOP-DR5 signaling.	arsenite	68-76	TNF receptor superfamily member 10b	Homo sapiens	126-129
32992901-8	2020	Following acute arsenite stress, all phospho-TDP-43 foci colocalize with SGs.	arsenite	16-24	TAR DNA binding protein	Homo sapiens	45-51
32992901-10	2020	Finally, formation of TDP-43 cytoplasmic foci following low-dose chronic arsenite stress is impaired, but not completely blocked, in G3BP1/2DeltaDelta cells.	arsenite	73-81	TAR DNA binding protein	Homo sapiens	22-28
32531574-0	2020	Role of GH/IGF axis in arsenite-induced developmental toxicity in zebrafish embryos.	arsenite	23-31	growth hormone 1	Danio rerio	8-14
32531574-2	2020	However, the effect of arsenite exposure on the GH/IGF axis and its toxic mechanism are still unclear.	arsenite	23-31	growth hormone 1	Danio rerio	48-50
32531574-11	2020	These findings suggested that arsenite exerted disruptive effects on the endocrine system by interfering with the GH/IGF axis, leading to zebrafish embryonic developmental toxicity.	arsenite	30-38	growth hormone 1	Danio rerio	114-116
32683294-0	2020	Arsenite-induced downregulation of occludin in mouse lungs and BEAS-2B cells via the ROS/ERK/ELK1/MLCK and ROS/p38 MAPK signaling pathways.	arsenite	0-8	mitogen-activated protein kinase 1	Homo sapiens	89-92
32683294-0	2020	Arsenite-induced downregulation of occludin in mouse lungs and BEAS-2B cells via the ROS/ERK/ELK1/MLCK and ROS/p38 MAPK signaling pathways.	arsenite	0-8	ETS transcription factor ELK1	Homo sapiens	93-97
32683294-0	2020	Arsenite-induced downregulation of occludin in mouse lungs and BEAS-2B cells via the ROS/ERK/ELK1/MLCK and ROS/p38 MAPK signaling pathways.	arsenite	0-8	myosin light chain kinase 3	Homo sapiens	98-102
32899721-8	2020	Our results show that non-toxic concentrations of arsenite induced Hsp70 expression in canine macrophages; Hsp70 upregulation significantly inhibited the LPS-induced expression of the pro-inflammatory mediators TNF-alpha and IL-6, as well as NF-kappaB activation in canine macrophages.	arsenite	50-58	heat shock 70 kDa protein 1	Canis lupus familiaris	67-72
32450402-0	2020	Long-term arsenite exposure decreases autophagy by increased release of Nrf2 in transformed human keratinocytes.	arsenite	10-18	NFE2 like bZIP transcription factor 2	Homo sapiens	72-76
32450402-3	2020	Herein, this study investigated molecular mechanisms of arsenite-induced autophagy dysfunction mediated by nuclear factor erythroid-2 related factor 2 (Nrf2) in human keratinocyte (HaCaT) cells.	arsenite	56-64	NFE2 like bZIP transcription factor 2	Homo sapiens	107-150
32450402-3	2020	Herein, this study investigated molecular mechanisms of arsenite-induced autophagy dysfunction mediated by nuclear factor erythroid-2 related factor 2 (Nrf2) in human keratinocyte (HaCaT) cells.	arsenite	56-64	NFE2 like bZIP transcription factor 2	Homo sapiens	152-156
32450402-4	2020	The effects of long-term arsenite exposure on Nrf2 activation and autophagy were established using a siRNA interference assay and western blots.	arsenite	25-33	NFE2 like bZIP transcription factor 2	Homo sapiens	46-50
32450402-5	2020	A specific siRNA of Nrf2 was used to verify that autophagy induced by arsenite can be influenced by Nrf2.	arsenite	70-78	NFE2 like bZIP transcription factor 2	Homo sapiens	20-24
32450402-5	2020	A specific siRNA of Nrf2 was used to verify that autophagy induced by arsenite can be influenced by Nrf2.	arsenite	70-78	NFE2 like bZIP transcription factor 2	Homo sapiens	100-104
32450402-7	2020	Downstream mTOR and Bcl2 were upregulated by Nrf2 signaling, inhibiting autophagy initiation in arsenite-exposed HaCaT cells.	arsenite	96-104	mechanistic target of rapamycin kinase	Homo sapiens	11-15
32450402-7	2020	Downstream mTOR and Bcl2 were upregulated by Nrf2 signaling, inhibiting autophagy initiation in arsenite-exposed HaCaT cells.	arsenite	96-104	BCL2 apoptosis regulator	Homo sapiens	20-24
32450402-7	2020	Downstream mTOR and Bcl2 were upregulated by Nrf2 signaling, inhibiting autophagy initiation in arsenite-exposed HaCaT cells.	arsenite	96-104	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
32450402-8	2020	In conclusion, our data suggest that long-term exposure to arsenite promotes Nrf2 upregulation via the PI3K/Akt pathway and, along with upregulation of downstream mTOR and Bcl2, contributes to autophagy dysfunction in transformed HaCaT cells.	arsenite	59-67	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
32450402-8	2020	In conclusion, our data suggest that long-term exposure to arsenite promotes Nrf2 upregulation via the PI3K/Akt pathway and, along with upregulation of downstream mTOR and Bcl2, contributes to autophagy dysfunction in transformed HaCaT cells.	arsenite	59-67	AKT serine/threonine kinase 1	Homo sapiens	108-111
32450402-8	2020	In conclusion, our data suggest that long-term exposure to arsenite promotes Nrf2 upregulation via the PI3K/Akt pathway and, along with upregulation of downstream mTOR and Bcl2, contributes to autophagy dysfunction in transformed HaCaT cells.	arsenite	59-67	mechanistic target of rapamycin kinase	Homo sapiens	163-167
32450402-8	2020	In conclusion, our data suggest that long-term exposure to arsenite promotes Nrf2 upregulation via the PI3K/Akt pathway and, along with upregulation of downstream mTOR and Bcl2, contributes to autophagy dysfunction in transformed HaCaT cells.	arsenite	59-67	BCL2 apoptosis regulator	Homo sapiens	172-176
32899721-5	2020	To this end, a canine macrophage cell line was stressed with arsenite, a chemical stressor, which upregulated Hsp70 expression as detected by flow cytometry and qPCR.	arsenite	61-69	heat shock 70 kDa protein 1	Canis lupus familiaris	110-115
32819598-0	2020	Arsenite suppresses the transcriptional activity of EVI1 through the binding to CCHC-type Zn finger domain.	arsenite	0-8	MDS1 and EVI1 complex locus	Homo sapiens	52-56
32819598-3	2020	Here we found that treatment of EVI1-expressing K562 cells with arsenite (As(III)) reduced the mRNA and protein levels of EVI1 and GATA-2.	arsenite	64-72	MDS1 and EVI1 complex locus	Homo sapiens	32-36
32819598-3	2020	Here we found that treatment of EVI1-expressing K562 cells with arsenite (As(III)) reduced the mRNA and protein levels of EVI1 and GATA-2.	arsenite	64-72	MDS1 and EVI1 complex locus	Homo sapiens	122-126
32819598-3	2020	Here we found that treatment of EVI1-expressing K562 cells with arsenite (As(III)) reduced the mRNA and protein levels of EVI1 and GATA-2.	arsenite	64-72	GATA binding protein 2	Homo sapiens	131-137
32899721-8	2020	Our results show that non-toxic concentrations of arsenite induced Hsp70 expression in canine macrophages; Hsp70 upregulation significantly inhibited the LPS-induced expression of the pro-inflammatory mediators TNF-alpha and IL-6, as well as NF-kappaB activation in canine macrophages.	arsenite	50-58	heat shock 70 kDa protein 1	Canis lupus familiaris	107-112
32899721-8	2020	Our results show that non-toxic concentrations of arsenite induced Hsp70 expression in canine macrophages; Hsp70 upregulation significantly inhibited the LPS-induced expression of the pro-inflammatory mediators TNF-alpha and IL-6, as well as NF-kappaB activation in canine macrophages.	arsenite	50-58	tumor necrosis factor	Canis lupus familiaris	211-220
32899721-8	2020	Our results show that non-toxic concentrations of arsenite induced Hsp70 expression in canine macrophages; Hsp70 upregulation significantly inhibited the LPS-induced expression of the pro-inflammatory mediators TNF-alpha and IL-6, as well as NF-kappaB activation in canine macrophages.	arsenite	50-58	interleukin 6	Canis lupus familiaris	225-229
32428768-6	2020	In addition, the electron transfer path in the photocatalytic oxidation system on arsenite was proposed according to the Mott-Schottky (MS) plots of SnS2 and graphitic carbon.	arsenite	82-90	sodium voltage-gated channel alpha subunit 11	Homo sapiens	149-153
32580031-3	2020	In addition, the mitochondrial expression of SVCT2 appeared particularly elevated and, consistently, a brief pre-exposure to low concentrations of Ascorbic Acid (AA) abolished mitochondrial superoxide formation selectively induced by the cocktail arsenite/ATP.	arsenite	247-255	solute carrier family 23 member 2	Homo sapiens	45-50
32435915-2	2020	In contrast, arsenic trioxide (As2O3) is an effective therapeutic agent for the treatment of acute promyelocytic leukemia, in which the binding of arsenite (iAsIII) to promyelocytic leukemia (PML) protein is the proposed initial step.	arsenite	147-155	PML nuclear body scaffold	Homo sapiens	192-195
32520986-4	2020	Using single mRNA imaging, we discovered ribosomes stall on some mRNAs during arsenite stress, and the release of transcripts from stalled ribosomes for their partitioning into stress granules requires the activities of VCP, components of the ribosome-associated quality control (RQC) complex, and the proteasome.	arsenite	78-86	valosin containing protein	Homo sapiens	220-223
32373892-0	2020	Linc-ROR promotes arsenite-transformed keratinocyte proliferation by inhibiting P53 activity.	arsenite	18-26	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	0-8
32428649-0	2020	In utero exposure to arsenite contributes to metabolic and reproductive dysfunction in male offspring of CD-1 mice.	arsenite	21-29	CD1 antigen complex	Mus musculus	105-109
32324387-0	2020	Arsenite Binds to ZNF598 to Perturb Ribosome-Associated Protein Quality Control.	arsenite	0-8	zinc finger protein 598, E3 ubiquitin ligase	Homo sapiens	18-24
32324387-4	2020	Here, we showed that arsenite interacts with ZNF598 protein in cells and exposure of human skin fibroblasts to arsenite resulted in significant decreases in the ubiquitination levels of lysine residues 138 and 139 in RPS10, and lysine 8 in RPS20, which are regulatory post-translational modifications important in ribosome-associated protein quality control.	arsenite	21-29	zinc finger protein 598, E3 ubiquitin ligase	Homo sapiens	45-51
32324387-4	2020	Here, we showed that arsenite interacts with ZNF598 protein in cells and exposure of human skin fibroblasts to arsenite resulted in significant decreases in the ubiquitination levels of lysine residues 138 and 139 in RPS10, and lysine 8 in RPS20, which are regulatory post-translational modifications important in ribosome-associated protein quality control.	arsenite	21-29	ribosomal protein S10	Homo sapiens	217-222
32324387-4	2020	Here, we showed that arsenite interacts with ZNF598 protein in cells and exposure of human skin fibroblasts to arsenite resulted in significant decreases in the ubiquitination levels of lysine residues 138 and 139 in RPS10, and lysine 8 in RPS20, which are regulatory post-translational modifications important in ribosome-associated protein quality control.	arsenite	21-29	ribosomal protein S20	Homo sapiens	240-245
32324387-4	2020	Here, we showed that arsenite interacts with ZNF598 protein in cells and exposure of human skin fibroblasts to arsenite resulted in significant decreases in the ubiquitination levels of lysine residues 138 and 139 in RPS10, and lysine 8 in RPS20, which are regulatory post-translational modifications important in ribosome-associated protein quality control.	arsenite	111-119	zinc finger protein 598, E3 ubiquitin ligase	Homo sapiens	45-51
32324387-4	2020	Here, we showed that arsenite interacts with ZNF598 protein in cells and exposure of human skin fibroblasts to arsenite resulted in significant decreases in the ubiquitination levels of lysine residues 138 and 139 in RPS10, and lysine 8 in RPS20, which are regulatory post-translational modifications important in ribosome-associated protein quality control.	arsenite	111-119	ribosomal protein S10	Homo sapiens	217-222
32324387-4	2020	Here, we showed that arsenite interacts with ZNF598 protein in cells and exposure of human skin fibroblasts to arsenite resulted in significant decreases in the ubiquitination levels of lysine residues 138 and 139 in RPS10, and lysine 8 in RPS20, which are regulatory post-translational modifications important in ribosome-associated protein quality control.	arsenite	111-119	ribosomal protein S20	Homo sapiens	240-245
32324387-5	2020	Furthermore, the arsenite-elicited diminutions in ubiquitinations of RPS10 and RPS20 gave rise to augmented read-through of poly(adenosine)-containing stalling sequences, which was abolished in ZNF598 knockout cells.	arsenite	17-25	ribosomal protein S10	Homo sapiens	69-74
32324387-5	2020	Furthermore, the arsenite-elicited diminutions in ubiquitinations of RPS10 and RPS20 gave rise to augmented read-through of poly(adenosine)-containing stalling sequences, which was abolished in ZNF598 knockout cells.	arsenite	17-25	ribosomal protein S20	Homo sapiens	79-84
32324387-5	2020	Furthermore, the arsenite-elicited diminutions in ubiquitinations of RPS10 and RPS20 gave rise to augmented read-through of poly(adenosine)-containing stalling sequences, which was abolished in ZNF598 knockout cells.	arsenite	17-25	zinc finger protein 598, E3 ubiquitin ligase	Homo sapiens	194-200
32765280-0	2020	JNK and Autophagy Independently Contributed to Cytotoxicity of Arsenite combined With Tetrandrine via Modulating Cell Cycle Progression in Human Breast Cancer Cells.	arsenite	63-71	mitogen-activated protein kinase 8	Homo sapiens	0-3
32373892-4	2020	Then we examined the linc-ROR expression during the transformation and explored the effect of linc-ROR on the cell proliferation of arsenite-transformed HaCaT cells.	arsenite	132-140	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	94-102
32373892-5	2020	We found that the linc-ROR level in HaCaT cells was gradually increased during arsenite-induced malignant transformation, and the activity of P53 was decreased, but the P53 expression was not significantly altered, indicating that linc-ROR may play a role in arsenite-induced HaCaT cell transformation that is associated with P53 activity but not P53 expression.	arsenite	79-87	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	18-26
32373892-5	2020	We found that the linc-ROR level in HaCaT cells was gradually increased during arsenite-induced malignant transformation, and the activity of P53 was decreased, but the P53 expression was not significantly altered, indicating that linc-ROR may play a role in arsenite-induced HaCaT cell transformation that is associated with P53 activity but not P53 expression.	arsenite	79-87	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	231-239
32373892-5	2020	We found that the linc-ROR level in HaCaT cells was gradually increased during arsenite-induced malignant transformation, and the activity of P53 was decreased, but the P53 expression was not significantly altered, indicating that linc-ROR may play a role in arsenite-induced HaCaT cell transformation that is associated with P53 activity but not P53 expression.	arsenite	259-267	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	18-26
32373892-5	2020	We found that the linc-ROR level in HaCaT cells was gradually increased during arsenite-induced malignant transformation, and the activity of P53 was decreased, but the P53 expression was not significantly altered, indicating that linc-ROR may play a role in arsenite-induced HaCaT cell transformation that is associated with P53 activity but not P53 expression.	arsenite	259-267	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	231-239
32373892-6	2020	We further demonstrated that linc-ROR down-regulation by siRNA significantly inhibited the cellular proliferation and restored P53 activity in arsenite-transformed HaCaT cells, suggesting that linc-ROR promotes proliferation of arsenite-transformed HaCaT cells by inhibiting P53 activity.	arsenite	143-151	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	29-37
32373892-6	2020	We further demonstrated that linc-ROR down-regulation by siRNA significantly inhibited the cellular proliferation and restored P53 activity in arsenite-transformed HaCaT cells, suggesting that linc-ROR promotes proliferation of arsenite-transformed HaCaT cells by inhibiting P53 activity.	arsenite	143-151	tumor protein p53	Homo sapiens	127-130
32373892-6	2020	We further demonstrated that linc-ROR down-regulation by siRNA significantly inhibited the cellular proliferation and restored P53 activity in arsenite-transformed HaCaT cells, suggesting that linc-ROR promotes proliferation of arsenite-transformed HaCaT cells by inhibiting P53 activity.	arsenite	143-151	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	193-201
32373892-6	2020	We further demonstrated that linc-ROR down-regulation by siRNA significantly inhibited the cellular proliferation and restored P53 activity in arsenite-transformed HaCaT cells, suggesting that linc-ROR promotes proliferation of arsenite-transformed HaCaT cells by inhibiting P53 activity.	arsenite	228-236	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	29-37
32373892-6	2020	We further demonstrated that linc-ROR down-regulation by siRNA significantly inhibited the cellular proliferation and restored P53 activity in arsenite-transformed HaCaT cells, suggesting that linc-ROR promotes proliferation of arsenite-transformed HaCaT cells by inhibiting P53 activity.	arsenite	228-236	tumor protein p53	Homo sapiens	127-130
32373892-6	2020	We further demonstrated that linc-ROR down-regulation by siRNA significantly inhibited the cellular proliferation and restored P53 activity in arsenite-transformed HaCaT cells, suggesting that linc-ROR promotes proliferation of arsenite-transformed HaCaT cells by inhibiting P53 activity.	arsenite	228-236	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	193-201
32373892-6	2020	We further demonstrated that linc-ROR down-regulation by siRNA significantly inhibited the cellular proliferation and restored P53 activity in arsenite-transformed HaCaT cells, suggesting that linc-ROR promotes proliferation of arsenite-transformed HaCaT cells by inhibiting P53 activity.	arsenite	228-236	tumor protein p53	Homo sapiens	275-278
32373892-7	2020	Moreover, linc-ROR siRNA also down-regulated the PI3K/AKT pathway in arsenite-transformed HaCaT cells, and treatment with AKT inhibitor wortmannin restored P53 activity, implying that linc-ROR inhibits P53 activity by activating the PI3K/AKT pathway.	arsenite	69-77	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	10-18
32373892-7	2020	Moreover, linc-ROR siRNA also down-regulated the PI3K/AKT pathway in arsenite-transformed HaCaT cells, and treatment with AKT inhibitor wortmannin restored P53 activity, implying that linc-ROR inhibits P53 activity by activating the PI3K/AKT pathway.	arsenite	69-77	AKT serine/threonine kinase 1	Homo sapiens	54-57
32373892-7	2020	Moreover, linc-ROR siRNA also down-regulated the PI3K/AKT pathway in arsenite-transformed HaCaT cells, and treatment with AKT inhibitor wortmannin restored P53 activity, implying that linc-ROR inhibits P53 activity by activating the PI3K/AKT pathway.	arsenite	69-77	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	184-192
32373892-7	2020	Moreover, linc-ROR siRNA also down-regulated the PI3K/AKT pathway in arsenite-transformed HaCaT cells, and treatment with AKT inhibitor wortmannin restored P53 activity, implying that linc-ROR inhibits P53 activity by activating the PI3K/AKT pathway.	arsenite	69-77	tumor protein p53	Homo sapiens	202-205
32373892-8	2020	Taken together, the present study shows that linc-ROR promotes arsenite-transformed keratinocyte proliferation by inhibiting P53 activity through activating PI3K/AKT, providing a novel carcinogenic mechanism of arsenite-induced skin cancer.	arsenite	63-71	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	45-53
32373892-8	2020	Taken together, the present study shows that linc-ROR promotes arsenite-transformed keratinocyte proliferation by inhibiting P53 activity through activating PI3K/AKT, providing a novel carcinogenic mechanism of arsenite-induced skin cancer.	arsenite	63-71	tumor protein p53	Homo sapiens	125-128
32373892-8	2020	Taken together, the present study shows that linc-ROR promotes arsenite-transformed keratinocyte proliferation by inhibiting P53 activity through activating PI3K/AKT, providing a novel carcinogenic mechanism of arsenite-induced skin cancer.	arsenite	63-71	AKT serine/threonine kinase 1	Homo sapiens	162-165
32373892-8	2020	Taken together, the present study shows that linc-ROR promotes arsenite-transformed keratinocyte proliferation by inhibiting P53 activity through activating PI3K/AKT, providing a novel carcinogenic mechanism of arsenite-induced skin cancer.	arsenite	211-219	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	45-53
32373892-8	2020	Taken together, the present study shows that linc-ROR promotes arsenite-transformed keratinocyte proliferation by inhibiting P53 activity through activating PI3K/AKT, providing a novel carcinogenic mechanism of arsenite-induced skin cancer.	arsenite	211-219	AKT serine/threonine kinase 1	Homo sapiens	162-165
32406909-4	2020	By comparing these compartments before and after short-term arsenite-induced oxidative stress, we identified three major categories of transcripts, namely those that were G3BP1-associated and PS-depleted, G3BP1-dissociated and PS-enriched, and G3BP1-associated but also PS-enriched.	arsenite	60-68	G3BP stress granule assembly factor 1	Homo sapiens	171-176
32406909-4	2020	By comparing these compartments before and after short-term arsenite-induced oxidative stress, we identified three major categories of transcripts, namely those that were G3BP1-associated and PS-depleted, G3BP1-dissociated and PS-enriched, and G3BP1-associated but also PS-enriched.	arsenite	60-68	G3BP stress granule assembly factor 1	Homo sapiens	205-210
32406909-4	2020	By comparing these compartments before and after short-term arsenite-induced oxidative stress, we identified three major categories of transcripts, namely those that were G3BP1-associated and PS-depleted, G3BP1-dissociated and PS-enriched, and G3BP1-associated but also PS-enriched.	arsenite	60-68	G3BP stress granule assembly factor 1	Homo sapiens	205-210
32406909-6	2020	Under arsenite stress, G3BP1-associated and PS-depleted transcripts correlated with reduced expression of encoded mitochondrial proteins, PS-enriched transcripts that disassociated from G3BP1 encoded cell cycle and cytoprotective proteins whose expression increased, while transcripts that were both G3BP1-associated and PS-enriched encoded proteins involved in diverse stress response pathways.	arsenite	6-14	G3BP stress granule assembly factor 1	Homo sapiens	23-28
32406909-6	2020	Under arsenite stress, G3BP1-associated and PS-depleted transcripts correlated with reduced expression of encoded mitochondrial proteins, PS-enriched transcripts that disassociated from G3BP1 encoded cell cycle and cytoprotective proteins whose expression increased, while transcripts that were both G3BP1-associated and PS-enriched encoded proteins involved in diverse stress response pathways.	arsenite	6-14	G3BP stress granule assembly factor 1	Homo sapiens	186-191
32406909-6	2020	Under arsenite stress, G3BP1-associated and PS-depleted transcripts correlated with reduced expression of encoded mitochondrial proteins, PS-enriched transcripts that disassociated from G3BP1 encoded cell cycle and cytoprotective proteins whose expression increased, while transcripts that were both G3BP1-associated and PS-enriched encoded proteins involved in diverse stress response pathways.	arsenite	6-14	G3BP stress granule assembly factor 1	Homo sapiens	186-191
32443253-0	2020	Calreticulin regulated intrinsic apoptosis through mitochondria-dependent and independent pathways mediated by ER stress in arsenite exposed HT-22 cells.	arsenite	124-132	calreticulin	Mus musculus	0-12
32443253-6	2020	Whether CRT plays a role in arsenite-induced apoptosis and the relationship between CRT and ER stress-mediated apoptosis have not been mentioned before.	arsenite	28-36	calreticulin	Mus musculus	8-11
32443253-7	2020	In this study, we found that CRT expression as well as the cell apoptosis levels increased in a dose dependent manner upon arsenite exposure in HT-22 cells, a mouse hippocampal neural cell line.	arsenite	123-131	calreticulin	Mus musculus	29-32
32443253-8	2020	In addition, arsenite exposure resulted in the up-regulation of ER stress indicator GRP78 and ER stress-related proteins including p-PERK, ATF4, CHOP, calpain2 and cleaved caspases-12, accompanied by the down-regulation of Bcl-2 and up-regulation of Bax and cleaved caspase-3.	arsenite	13-21	heat shock protein 5	Mus musculus	84-89
32443253-8	2020	In addition, arsenite exposure resulted in the up-regulation of ER stress indicator GRP78 and ER stress-related proteins including p-PERK, ATF4, CHOP, calpain2 and cleaved caspases-12, accompanied by the down-regulation of Bcl-2 and up-regulation of Bax and cleaved caspase-3.	arsenite	13-21	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	133-137
32443253-8	2020	In addition, arsenite exposure resulted in the up-regulation of ER stress indicator GRP78 and ER stress-related proteins including p-PERK, ATF4, CHOP, calpain2 and cleaved caspases-12, accompanied by the down-regulation of Bcl-2 and up-regulation of Bax and cleaved caspase-3.	arsenite	13-21	activating transcription factor 4	Mus musculus	139-143
32443253-8	2020	In addition, arsenite exposure resulted in the up-regulation of ER stress indicator GRP78 and ER stress-related proteins including p-PERK, ATF4, CHOP, calpain2 and cleaved caspases-12, accompanied by the down-regulation of Bcl-2 and up-regulation of Bax and cleaved caspase-3.	arsenite	13-21	DNA-damage inducible transcript 3	Mus musculus	145-149
32443253-8	2020	In addition, arsenite exposure resulted in the up-regulation of ER stress indicator GRP78 and ER stress-related proteins including p-PERK, ATF4, CHOP, calpain2 and cleaved caspases-12, accompanied by the down-regulation of Bcl-2 and up-regulation of Bax and cleaved caspase-3.	arsenite	13-21	calpain 2	Mus musculus	151-159
32443253-8	2020	In addition, arsenite exposure resulted in the up-regulation of ER stress indicator GRP78 and ER stress-related proteins including p-PERK, ATF4, CHOP, calpain2 and cleaved caspases-12, accompanied by the down-regulation of Bcl-2 and up-regulation of Bax and cleaved caspase-3.	arsenite	13-21	B cell leukemia/lymphoma 2	Mus musculus	223-228
32443253-8	2020	In addition, arsenite exposure resulted in the up-regulation of ER stress indicator GRP78 and ER stress-related proteins including p-PERK, ATF4, CHOP, calpain2 and cleaved caspases-12, accompanied by the down-regulation of Bcl-2 and up-regulation of Bax and cleaved caspase-3.	arsenite	13-21	BCL2-associated X protein	Mus musculus	250-253
32443253-8	2020	In addition, arsenite exposure resulted in the up-regulation of ER stress indicator GRP78 and ER stress-related proteins including p-PERK, ATF4, CHOP, calpain2 and cleaved caspases-12, accompanied by the down-regulation of Bcl-2 and up-regulation of Bax and cleaved caspase-3.	arsenite	13-21	caspase 3	Mus musculus	266-275
32443253-9	2020	Silence of CRT remarkably alleviated arsenite-induced apoptosis and reversed the expression of the proteins above.	arsenite	37-45	calreticulin	Mus musculus	11-14
32443253-10	2020	Our findings confirmed the role of CRT in the induction of apoptosis upon arsenite exposure and suggested that CRT mediated the intrinsic apoptotic cell death including both mitochondria-dependent (PERK/ATF4/CHOP/Bcl-2) and independent (calpain2/caspases-12) pathways initiated by ER stress, which we believed to be a previously undocumented property of arsenite-induced apoptosis.	arsenite	74-82	calreticulin	Mus musculus	35-38
32443253-10	2020	Our findings confirmed the role of CRT in the induction of apoptosis upon arsenite exposure and suggested that CRT mediated the intrinsic apoptotic cell death including both mitochondria-dependent (PERK/ATF4/CHOP/Bcl-2) and independent (calpain2/caspases-12) pathways initiated by ER stress, which we believed to be a previously undocumented property of arsenite-induced apoptosis.	arsenite	354-362	calreticulin	Mus musculus	111-114
32315827-7	2020	The recovery from arsenite exposure was associated with increased levels of PEDF; decreased protein levels of Fas, FasL, P53, and phospho-p38; and inhibited apoptosis in aortic endothelial cells in vivo.	arsenite	18-26	serpin family F member 1	Rattus norvegicus	76-80
32315827-7	2020	The recovery from arsenite exposure was associated with increased levels of PEDF; decreased protein levels of Fas, FasL, P53, and phospho-p38; and inhibited apoptosis in aortic endothelial cells in vivo.	arsenite	18-26	Fas ligand	Rattus norvegicus	115-119
32315827-7	2020	The recovery from arsenite exposure was associated with increased levels of PEDF; decreased protein levels of Fas, FasL, P53, and phospho-p38; and inhibited apoptosis in aortic endothelial cells in vivo.	arsenite	18-26	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	121-124
32315827-7	2020	The recovery from arsenite exposure was associated with increased levels of PEDF; decreased protein levels of Fas, FasL, P53, and phospho-p38; and inhibited apoptosis in aortic endothelial cells in vivo.	arsenite	18-26	mitogen activated protein kinase 14	Rattus norvegicus	138-141
32315827-8	2020	Recombinant human PEDF treatment (100 nM) prevented the toxic effects of arsenite (50 muM) on endothelial cells in vitro by increasing NO content, decreasing reactive oxygen species (ROS) levels, and inhibiting apoptosis, as well as increasing cell viability and decreasing levels of P53 and phospho-p38.	arsenite	73-81	serpin family F member 1	Homo sapiens	18-22
32315827-8	2020	Recombinant human PEDF treatment (100 nM) prevented the toxic effects of arsenite (50 muM) on endothelial cells in vitro by increasing NO content, decreasing reactive oxygen species (ROS) levels, and inhibiting apoptosis, as well as increasing cell viability and decreasing levels of P53 and phospho-p38.	arsenite	73-81	tumor protein p53	Homo sapiens	284-287
32315827-8	2020	Recombinant human PEDF treatment (100 nM) prevented the toxic effects of arsenite (50 muM) on endothelial cells in vitro by increasing NO content, decreasing reactive oxygen species (ROS) levels, and inhibiting apoptosis, as well as increasing cell viability and decreasing levels of P53 and phospho-p38.	arsenite	73-81	mitogen-activated protein kinase 14	Homo sapiens	300-303
32274925-0	2020	Arsenite Exposure Displaces Zinc from ZRANB2 Leading to Altered Splicing.	arsenite	0-8	zinc finger RANBP2-type containing 2	Homo sapiens	38-44
32142838-0	2020	Arsenite-induced transgenerational glycometabolism is associated with up-regulation of H3K4me2 via inhibiting spr-5 in caenorhabditis elegans.	arsenite	0-8	putative lysine-specific histone demethylase 1	Caenorhabditis elegans	110-115
32142838-8	2020	In addition, arsenite exposure induced transgenerational downregulation of histone demethyltransferase spr-5 and elevated histone dimethylation in F0 generation.	arsenite	13-21	putative lysine-specific histone demethylase 1	Caenorhabditis elegans	103-108
32142838-9	2020	This study highlights that single generation exposure to arsenite causes transgenerational changes in glycometabolism in C. elegans, which may be caused by downregulation of spr-5 and elevation of H3K4me2.	arsenite	57-65	putative lysine-specific histone demethylase 1	Caenorhabditis elegans	174-179
32373892-0	2020	Linc-ROR promotes arsenite-transformed keratinocyte proliferation by inhibiting P53 activity.	arsenite	18-26	tumor protein p53	Homo sapiens	80-83
32373892-3	2020	To explore whether and how linc-ROR plays a role in arsenite-induced carcinogenesis of skin cancer, we established arsenite-transformed keratinocyte HaCaT cells by exposing them to 1 muM arsenite for 50 passages.	arsenite	52-60	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	27-35
32373892-3	2020	To explore whether and how linc-ROR plays a role in arsenite-induced carcinogenesis of skin cancer, we established arsenite-transformed keratinocyte HaCaT cells by exposing them to 1 muM arsenite for 50 passages.	arsenite	115-123	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	27-35
32373892-3	2020	To explore whether and how linc-ROR plays a role in arsenite-induced carcinogenesis of skin cancer, we established arsenite-transformed keratinocyte HaCaT cells by exposing them to 1 muM arsenite for 50 passages.	arsenite	115-123	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	27-35
32265434-0	2020	Selective degradation of IKKalpha by autophagy is essential for arsenite-induced cancer cell apoptosis.	arsenite	64-72	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	25-33
32126253-8	2020	LC3-II and p62 levels were increased after exposure to arsenite and lipopolysaccharide (LPS).	arsenite	55-63	nucleoporin 62	Mus musculus	11-14
32416464-15	2020	However, the cells exposed to arsenite are transformed by the continuous nuclear translocation of Nrf2 due to oxidative stress, and the persulfide from dimethylthioarsenics may promote Nrf2 by the combination with thiol groups, especially redox control key protein, Keap1, eventually cause nuclear translocation of sustained Nrf2.	arsenite	30-38	NFE2 like bZIP transcription factor 2	Homo sapiens	98-102
32416464-15	2020	However, the cells exposed to arsenite are transformed by the continuous nuclear translocation of Nrf2 due to oxidative stress, and the persulfide from dimethylthioarsenics may promote Nrf2 by the combination with thiol groups, especially redox control key protein, Keap1, eventually cause nuclear translocation of sustained Nrf2.	arsenite	30-38	NFE2 like bZIP transcription factor 2	Homo sapiens	185-189
32416464-15	2020	However, the cells exposed to arsenite are transformed by the continuous nuclear translocation of Nrf2 due to oxidative stress, and the persulfide from dimethylthioarsenics may promote Nrf2 by the combination with thiol groups, especially redox control key protein, Keap1, eventually cause nuclear translocation of sustained Nrf2.	arsenite	30-38	kelch like ECH associated protein 1	Homo sapiens	266-271
32416464-15	2020	However, the cells exposed to arsenite are transformed by the continuous nuclear translocation of Nrf2 due to oxidative stress, and the persulfide from dimethylthioarsenics may promote Nrf2 by the combination with thiol groups, especially redox control key protein, Keap1, eventually cause nuclear translocation of sustained Nrf2.	arsenite	30-38	NFE2 like bZIP transcription factor 2	Homo sapiens	185-189
32265434-2	2020	Here we identified the NF-kappaB-unrelated cytoprotective function of IKKalpha in promoting autophagy by triggering p53 transactivation and upregulation of its downstream autophagic mediator, DRAM1, in the arsenite-treated hepatoma cells, which responses depended on IKKalpha kinase activity.	arsenite	206-214	nuclear factor kappa B subunit 1	Homo sapiens	23-32
32265434-2	2020	Here we identified the NF-kappaB-unrelated cytoprotective function of IKKalpha in promoting autophagy by triggering p53 transactivation and upregulation of its downstream autophagic mediator, DRAM1, in the arsenite-treated hepatoma cells, which responses depended on IKKalpha kinase activity.	arsenite	206-214	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	70-78
32265434-2	2020	Here we identified the NF-kappaB-unrelated cytoprotective function of IKKalpha in promoting autophagy by triggering p53 transactivation and upregulation of its downstream autophagic mediator, DRAM1, in the arsenite-treated hepatoma cells, which responses depended on IKKalpha kinase activity.	arsenite	206-214	DNA damage regulated autophagy modulator 1	Homo sapiens	192-197
32265434-6	2020	Taken together, we conclude that IKKalpha attenuates arsenite-induced apoptosis by inducing p53-dependent autophagy, and then selective feedback degradation of IKKalpha by autophagy contributes to the cytotoxic response induced by arsenite.	arsenite	53-61	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	33-41
32265434-6	2020	Taken together, we conclude that IKKalpha attenuates arsenite-induced apoptosis by inducing p53-dependent autophagy, and then selective feedback degradation of IKKalpha by autophagy contributes to the cytotoxic response induced by arsenite.	arsenite	53-61	tumor protein p53	Homo sapiens	92-95
32265434-6	2020	Taken together, we conclude that IKKalpha attenuates arsenite-induced apoptosis by inducing p53-dependent autophagy, and then selective feedback degradation of IKKalpha by autophagy contributes to the cytotoxic response induced by arsenite.	arsenite	231-239	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	33-41
32265434-6	2020	Taken together, we conclude that IKKalpha attenuates arsenite-induced apoptosis by inducing p53-dependent autophagy, and then selective feedback degradation of IKKalpha by autophagy contributes to the cytotoxic response induced by arsenite.	arsenite	231-239	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	160-168
31597699-2	2019	To identify regulators that might control this dual activity of NOTCH1, we screened a chemical library targeting kinases and identified Polo-like kinase 1 (PLK1) as one of the kinases involved in arsenite-induced NOTCH1 down-modulation.	arsenite	196-204	notch receptor 1	Homo sapiens	64-70
31931413-0	2020	N6-methyladenosine mediates arsenite-induced human keratinocyte transformation by suppressing p53 activation.	arsenite	28-36	tumor protein p53	Homo sapiens	94-97
31931413-7	2020	Knockdown of the m6A methyltransferase, METTL3 significantly decreased m6A level, restoring p53 activation and inhibiting cellular transformation phenotypes in the arsenite-transformed cells.	arsenite	164-172	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	40-46
31931413-10	2020	Taken together, our study revealed the novel role of m6A in mediating arsenite-induced human keratinocyte transformation by suppressing p53 activation.	arsenite	70-78	tumor protein p53	Homo sapiens	136-139
33404549-0	2020	PIN FORMED 2 Modulates the Transport of Arsenite in Arabidopsis thaliana.	arsenite	40-48	Auxin efflux carrier family protein	Arabidopsis thaliana	0-12
33404549-6	2020	Root transport assay using radioactive arsenite, X-ray fluorescence imaging (XFI) coupled with X-ray absorption spectroscopy (XAS), and inductively coupled plasma mass spectrometry analysis revealed that pin2 plants accumulate higher concentrations of arsenite in roots compared with the wild-type.	arsenite	39-47	Auxin efflux carrier family protein	Arabidopsis thaliana	204-208
33404549-6	2020	Root transport assay using radioactive arsenite, X-ray fluorescence imaging (XFI) coupled with X-ray absorption spectroscopy (XAS), and inductively coupled plasma mass spectrometry analysis revealed that pin2 plants accumulate higher concentrations of arsenite in roots compared with the wild-type.	arsenite	252-260	Auxin efflux carrier family protein	Arabidopsis thaliana	204-208
33404549-7	2020	At the cellular level, arsenite specifically targets intracellular sorting of PIN2 and thereby alters the cellular auxin homeostasis.	arsenite	23-31	Auxin efflux carrier family protein	Arabidopsis thaliana	78-82
33404549-8	2020	Consistently, loss of PIN2 function results in arsenite hypersensitivity in roots.	arsenite	47-55	Auxin efflux carrier family protein	Arabidopsis thaliana	22-26
31272005-10	2019	N-acetylcysteine antagonized arsenite-mediated induction of HMOX1 expression as well as reduction of neuronal and oligodendrocyte differentiation in hNPC suggesting involvement of oxidative stress in arsenite DNT.	arsenite	29-37	heme oxygenase 1	Homo sapiens	60-65
31421213-6	2019	Previous toxicokinetic studies of arsenite ingestion in neonatal CD-1 mice showed consistent evidence for metabolic and physiologic immaturity that led to elevated internal exposures to trivalent arsenic species in the youngest mice, relative to adults.	arsenite	34-42	CD1 antigen complex	Mus musculus	65-69
31513886-0	2019	Exosomal MALAT1 derived from hepatic cells is involved in the activation of hepatic stellate cells via miRNA-26b in fibrosis induced by arsenite.	arsenite	136-144	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	9-15
31513886-6	2019	In mice, MALAT1 was overexpressed in the progression of liver fibrosis induced by arsenite as well as in L-02 cells exposed to arsenite.	arsenite	82-90	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	Mus musculus	9-15
31513886-6	2019	In mice, MALAT1 was overexpressed in the progression of liver fibrosis induced by arsenite as well as in L-02 cells exposed to arsenite.	arsenite	127-135	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	Mus musculus	9-15
31513886-7	2019	Co-cultures with arsenite-treated L-02 cells induced the activation of LX-2 cells and overexpression of MALAT1.	arsenite	17-25	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	104-110
31513886-8	2019	Arsenite-treated L-02 cells transported MALAT1 into LX-2 cells.	arsenite	0-8	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	40-46
31513886-9	2019	Downregulation of MALAT1, which reduced the MALAT1 levels in exosomes derived from arsenite-treated L-02 cells, inhibited the activation of LX-2 cells.	arsenite	83-91	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	18-24
31513886-9	2019	Downregulation of MALAT1, which reduced the MALAT1 levels in exosomes derived from arsenite-treated L-02 cells, inhibited the activation of LX-2 cells.	arsenite	83-91	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	44-50
31513886-10	2019	Additionally, exosomal MALAT1 derived from arsenite-treated L-02 cells promoted the activation of LX-2 cells via microRNA-26b regulation of COL1A2.	arsenite	43-51	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	23-29
31513886-10	2019	Additionally, exosomal MALAT1 derived from arsenite-treated L-02 cells promoted the activation of LX-2 cells via microRNA-26b regulation of COL1A2.	arsenite	43-51	collagen type I alpha 2 chain	Homo sapiens	140-146
31513886-11	2019	Furthermore, circulating exosomal MALAT1 was up-regulated in people exposed to arsenite.	arsenite	79-87	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	34-40
31513886-12	2019	In sum, exosomes derived from arsenite-treated hepatic cells transferred MALAT1 to HSCs, which induced their activation.	arsenite	30-38	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	73-79
31594991-6	2019	Our study revealed that arsenite significantly reduced differentiation of murine brown adipocytes and mitochondrial biogenesis and respiration, leading to attenuated thermogenesis via decreasing UCP1 expression.	arsenite	24-32	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	195-199
31594991-8	2019	Mechanistically, arsenite exposure significantly inhibited autophagy necessary for homeostasis of brown adipose tissue through suppression of Sestrin2 and ULK1.	arsenite	17-25	sestrin 2	Homo sapiens	142-150
31594991-8	2019	Mechanistically, arsenite exposure significantly inhibited autophagy necessary for homeostasis of brown adipose tissue through suppression of Sestrin2 and ULK1.	arsenite	17-25	unc-51 like autophagy activating kinase 1	Homo sapiens	155-159
31781319-3	2019	In the present study, we found that chronic exposure to an environmentally relevant dose of arsenite induced malignant transformation of human keratinocytes (HaCaT) with dysregulated autophagy as indicated by an increased number of autophagosomes, activation of mTORC1 pathway, and elevated protein levels of p62 and LC3II.	arsenite	92-100	CREB regulated transcription coactivator 1	Mus musculus	262-268
31781319-3	2019	In the present study, we found that chronic exposure to an environmentally relevant dose of arsenite induced malignant transformation of human keratinocytes (HaCaT) with dysregulated autophagy as indicated by an increased number of autophagosomes, activation of mTORC1 pathway, and elevated protein levels of p62 and LC3II.	arsenite	92-100	nucleoporin 62	Homo sapiens	309-312
31781319-5	2019	Silencing p62 ameliorated elevation in mRNA levels of NRF2 downstream genes (AKR1C1 and NQO1) and malignant phenotypes (acquired invasiveness and anchor-independent growth) induced by chronic arsenite exposure.	arsenite	192-200	nucleoporin 62	Homo sapiens	10-13
31781319-5	2019	Silencing p62 ameliorated elevation in mRNA levels of NRF2 downstream genes (AKR1C1 and NQO1) and malignant phenotypes (acquired invasiveness and anchor-independent growth) induced by chronic arsenite exposure.	arsenite	192-200	NFE2 like bZIP transcription factor 2	Homo sapiens	54-58
31781319-5	2019	Silencing p62 ameliorated elevation in mRNA levels of NRF2 downstream genes (AKR1C1 and NQO1) and malignant phenotypes (acquired invasiveness and anchor-independent growth) induced by chronic arsenite exposure.	arsenite	192-200	aldo-keto reductase family 1 member C1	Homo sapiens	77-83
31781319-5	2019	Silencing p62 ameliorated elevation in mRNA levels of NRF2 downstream genes (AKR1C1 and NQO1) and malignant phenotypes (acquired invasiveness and anchor-independent growth) induced by chronic arsenite exposure.	arsenite	192-200	NAD(P)H quinone dehydrogenase 1	Homo sapiens	88-92
31781319-6	2019	On the other hand, silencing NRF2 abrogated the increase in mRNA and protein levels of p62 and malignant phenotypes induced by arsenite.	arsenite	127-135	NFE2 like bZIP transcription factor 2	Homo sapiens	29-33
31781319-6	2019	On the other hand, silencing NRF2 abrogated the increase in mRNA and protein levels of p62 and malignant phenotypes induced by arsenite.	arsenite	127-135	nucleoporin 62	Homo sapiens	87-90
31781319-7	2019	In response to acute arsenite exposure, impaired autophagic flux with an increase in p62 protein level and interrupted autophagosome-lysosome fusion was observed.	arsenite	21-29	nucleoporin 62	Homo sapiens	85-88
31781319-8	2019	The increase in p62 protein levels in response to arsenite was not completely dependent on NRF2 activation and at least partially attributed to protein degradation.	arsenite	50-58	nucleoporin 62	Homo sapiens	16-19
31781319-9	2019	Our data indicate that accumulation of p62 by impaired autophagic flux is involved in the activation of NRF2 and contributes to skin tumorigenesis due to chronic arsenite exposure.	arsenite	162-170	nucleoporin 62	Homo sapiens	39-42
31412519-7	2019	These results suggest that the renal toxicity of As and F is associated with the induction of mitochondrial damage and oxidative stress, and alters the expression of Nrf2 and its regulatory targets.	arsenite	49-51	NFE2 like bZIP transcription factor 2	Rattus norvegicus	166-170
31597699-2	2019	To identify regulators that might control this dual activity of NOTCH1, we screened a chemical library targeting kinases and identified Polo-like kinase 1 (PLK1) as one of the kinases involved in arsenite-induced NOTCH1 down-modulation.	arsenite	196-204	polo like kinase 1	Homo sapiens	136-154
31597699-2	2019	To identify regulators that might control this dual activity of NOTCH1, we screened a chemical library targeting kinases and identified Polo-like kinase 1 (PLK1) as one of the kinases involved in arsenite-induced NOTCH1 down-modulation.	arsenite	196-204	polo like kinase 1	Homo sapiens	156-160
31597699-2	2019	To identify regulators that might control this dual activity of NOTCH1, we screened a chemical library targeting kinases and identified Polo-like kinase 1 (PLK1) as one of the kinases involved in arsenite-induced NOTCH1 down-modulation.	arsenite	196-204	notch receptor 1	Homo sapiens	213-219
31597699-8	2019	Interestingly, we found that arsenite-induced genotoxic stress causes a PLK1-dependent signaling response that antagonizes the involvement of NOTCH1 in the DNA damage checkpoint.	arsenite	29-37	polo like kinase 1	Homo sapiens	72-76
31597699-8	2019	Interestingly, we found that arsenite-induced genotoxic stress causes a PLK1-dependent signaling response that antagonizes the involvement of NOTCH1 in the DNA damage checkpoint.	arsenite	29-37	notch receptor 1	Homo sapiens	142-148
31436974-6	2019	Modeling of the As K-edge extended X-ray absorption fine structure data revealed that As   C interatomic distances were relatively longer in arsenate- (2.83 +- 0.01 A) and monothioarsenate-treated peat (2.80 +- 0.02 A) compared to arsenite treatments (2.73 +- 0.01 A).	arsenite	231-239	PYD and CARD domain containing	Homo sapiens	86-92
31398423-5	2019	Our results showed that arsenite inhibited GLUT1 trafficking, glucose uptake, and calpain activity in the presence of 11.1 mM of glucose.	arsenite	24-32	solute carrier family 2 member 1	Homo sapiens	43-48
31398423-7	2019	We used a cell-free system to evaluate the effect of arsenite over CAPN1, finding that arsenite induced CAPN1 autolysis.	arsenite	87-95	calpain 1	Homo sapiens	67-72
31398423-7	2019	We used a cell-free system to evaluate the effect of arsenite over CAPN1, finding that arsenite induced CAPN1 autolysis.	arsenite	87-95	calpain 1	Homo sapiens	104-109
31398423-11	2019	Altogether, our results suggest that arsenite impairs GLUT1 trafficking and function through calpain dysregulation.	arsenite	37-45	solute carrier family 2 member 1	Homo sapiens	54-59
31176655-9	2019	Analysis of mitoses revealed that chromosome number and structural abnormalities increased in cells overexpressing hsa-miR-186 and were further increased by arsenite exposure.	arsenite	157-165	microRNA 186	Homo sapiens	119-126
31176655-15	2019	Expression of BUB1, a predicted hsa-miR-186 target was suppressed in hsa-miR-186 overexpressing clones, but increased with arsenite exposure.	arsenite	123-131	BUB1 mitotic checkpoint serine/threonine kinase	Homo sapiens	14-18
31141459-0	2019	Methylated metabolite of arsenite blocks glycerol production in yeast by inhibition of glycerol-3-phosphate dehydrogenase.	arsenite	25-33	glycerol-3-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	87-121
31452676-1	2019	Background: A previous screen of a human kinase and phosphatase shRNA library to select genes that mediate arsenite induction of spindle abnormalities resulted in the identification of phosphatidylinositol-5-phosphate 4-kinase type-2 gamma (PIP4KIIgamma), a phosphatidylinositol 4,5-bisphosphate (PIP2)-synthesizing enzyme.	arsenite	107-115	phosphatidylinositol-5-phosphate 4-kinase type 2 gamma	Homo sapiens	185-239
31452676-1	2019	Background: A previous screen of a human kinase and phosphatase shRNA library to select genes that mediate arsenite induction of spindle abnormalities resulted in the identification of phosphatidylinositol-5-phosphate 4-kinase type-2 gamma (PIP4KIIgamma), a phosphatidylinositol 4,5-bisphosphate (PIP2)-synthesizing enzyme.	arsenite	107-115	phosphatidylinositol-5-phosphate 4-kinase type 2 gamma	Homo sapiens	241-253
31452676-8	2019	Consequently, depletion of PLK1 has been shown to counteract the PIP4KIIgamma depletion-induced instability of spindle pole-associated MT and cell resistance to arsenite.	arsenite	161-169	polo like kinase 1	Homo sapiens	27-31
31452676-8	2019	Consequently, depletion of PLK1 has been shown to counteract the PIP4KIIgamma depletion-induced instability of spindle pole-associated MT and cell resistance to arsenite.	arsenite	161-169	phosphatidylinositol-5-phosphate 4-kinase type 2 gamma	Homo sapiens	65-77
31215104-4	2019	Reduced-representation bisulfite sequencing analysis newly identified that DNA methylation levels of regions around the transcriptional start sites of Tmem54 and Cd74 were decreased and the expression of these genes were significantly increased in the hepatic tumors of F2 males of the arsenite group.	arsenite	286-294	transmembrane protein 54	Mus musculus	151-157
31215104-9	2019	These results suggested that an increase in Tmem54 and Cd74 expression via DNA methylation reduction was involved in the tumor increase in the F2 male offspring by gestational arsenite exposure of F0 females.	arsenite	176-184	transmembrane protein 54	Mus musculus	44-50
31215104-9	2019	These results suggested that an increase in Tmem54 and Cd74 expression via DNA methylation reduction was involved in the tumor increase in the F2 male offspring by gestational arsenite exposure of F0 females.	arsenite	176-184	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)	Mus musculus	55-59
31141459-3	2019	Treatment of yeast with the toxic trivalent metalloid arsenite (As(III)) also activates Hog1 as part of a protective response in which Hog1 closes Fps1, the main entry port for As(III).	arsenite	54-62	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	88-92
31141459-3	2019	Treatment of yeast with the toxic trivalent metalloid arsenite (As(III)) also activates Hog1 as part of a protective response in which Hog1 closes Fps1, the main entry port for As(III).	arsenite	54-62	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	135-139
31141459-3	2019	Treatment of yeast with the toxic trivalent metalloid arsenite (As(III)) also activates Hog1 as part of a protective response in which Hog1 closes Fps1, the main entry port for As(III).	arsenite	54-62	Fps1p	Saccharomyces cerevisiae S288C	147-151
31004932-1	2019	N6-methyladenosine (m6A) modification is affected by oxidative stress and gets involved in arsenite toxicity.	arsenite	91-99	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	20-23
31140275-0	2019	Targeted Quantitative Proteomics Revealed Arsenite-induced Proteasomal Degradation of RhoB in Fibroblast Cells.	arsenite	42-50	ras homolog family member B	Homo sapiens	86-90
31140275-7	2019	In addition, the protein level of ectopically expressed RhoB was found to decline in a dose-dependent manner upon arsenite exposure in HEK293T, HeLa, and GM00637 cells as well as that of endogenous RhoB protein in IMR90 cells.	arsenite	114-122	ras homolog family member B	Homo sapiens	56-60
31140275-8	2019	Moreover, the arsenite-elicited down-regulation of RhoB was found to arise from enhanced proteasomal degradation.	arsenite	14-22	ras homolog family member B	Homo sapiens	51-55
31140275-9	2019	Taken together, we demonstrated, for the first time, that exposure to arsenite could attenuate the protein expression of RhoB through proteasomal degradation.	arsenite	70-78	ras homolog family member B	Homo sapiens	121-125
31004932-2	2019	However, whether oxidative stress is one factor in arsenite-induced alteration of m6A levels remains unclear.	arsenite	51-59	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	82-85
31004932-4	2019	Antioxidant N-acetylcysteine was used to assess the influence of arsenite-induced oxidative stress on m6A modification.	arsenite	65-73	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	102-105
31004932-5	2019	Possible regulations of m6A modification induced by arsenite were explored using bioinformatic analysis.	arsenite	52-60	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	24-27
31004932-6	2019	Our results demonstrated that arsenite-induced oxidative stress increased the levels of m6A methylation possibly by mediating m6A methyltransferases and demethylases, especially elevated expressions of WTAP and METTL14, in human keratinocytes.	arsenite	30-38	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	88-91
31004932-6	2019	Our results demonstrated that arsenite-induced oxidative stress increased the levels of m6A methylation possibly by mediating m6A methyltransferases and demethylases, especially elevated expressions of WTAP and METTL14, in human keratinocytes.	arsenite	30-38	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	126-129
31004932-6	2019	Our results demonstrated that arsenite-induced oxidative stress increased the levels of m6A methylation possibly by mediating m6A methyltransferases and demethylases, especially elevated expressions of WTAP and METTL14, in human keratinocytes.	arsenite	30-38	WT1 associated protein	Homo sapiens	202-206
31004932-6	2019	Our results demonstrated that arsenite-induced oxidative stress increased the levels of m6A methylation possibly by mediating m6A methyltransferases and demethylases, especially elevated expressions of WTAP and METTL14, in human keratinocytes.	arsenite	30-38	methyltransferase 14, N6-adenosine-methyltransferase subunit	Homo sapiens	211-218
31004932-7	2019	Whereas N-acetylcysteine suppressed the elevated m6A level and its methyltransferases in human keratinocytes exposed to arsenite.	arsenite	120-128	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	49-52
31004932-8	2019	Furthermore, arsenite-induced oxidative stress might mediate m6A methyltransferases and demethylases by reducing transcription of 4 genes (HECTD4, ABCA5, SLC22 A17 and KCNQ5) according to our bioinformatic analysis and experiments.	arsenite	13-21	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	61-64
31004932-8	2019	Furthermore, arsenite-induced oxidative stress might mediate m6A methyltransferases and demethylases by reducing transcription of 4 genes (HECTD4, ABCA5, SLC22 A17 and KCNQ5) according to our bioinformatic analysis and experiments.	arsenite	13-21	HECT domain E3 ubiquitin protein ligase 4	Homo sapiens	139-145
31004932-8	2019	Furthermore, arsenite-induced oxidative stress might mediate m6A methyltransferases and demethylases by reducing transcription of 4 genes (HECTD4, ABCA5, SLC22 A17 and KCNQ5) according to our bioinformatic analysis and experiments.	arsenite	13-21	ATP binding cassette subfamily A member 5	Homo sapiens	147-152
31004932-8	2019	Furthermore, arsenite-induced oxidative stress might mediate m6A methyltransferases and demethylases by reducing transcription of 4 genes (HECTD4, ABCA5, SLC22 A17 and KCNQ5) according to our bioinformatic analysis and experiments.	arsenite	13-21	solute carrier family 22 member 17	Homo sapiens	154-163
31004932-8	2019	Furthermore, arsenite-induced oxidative stress might mediate m6A methyltransferases and demethylases by reducing transcription of 4 genes (HECTD4, ABCA5, SLC22 A17 and KCNQ5) according to our bioinformatic analysis and experiments.	arsenite	13-21	potassium voltage-gated channel subfamily Q member 5	Homo sapiens	168-173
31004932-9	2019	Additionally, GO and Pathway analysis further suggested that the increase of m6A modification in arsenite-induced oxidative stress might be involved in some biological processes such as positive regulation of GTPase activity, apoptotic process, and platelet activation.	arsenite	97-105	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	77-80
31004932-10	2019	Taken together, our study revealed the significant role of oxidative stress in m6A modification induced by arsenite.	arsenite	107-115	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	79-82
31187253-8	2019	A significant up-regulation of p-p5315 and p-p53392 can be observed when cells were exposed to arsenite at 5 mumol L-1 level for 24 h. Graphical abstract Schematic presentation of the ICP-MS immunoassay using apoferritin templated europium (III) and lutetium (III) phosphate nanoparticles as labels for the simultaneous determination of two phosphorylated p53 proteins.	arsenite	95-103	L1 cell adhesion molecule	Mus musculus	115-118
30806671-5	2019	To address these questions, a quantitative proteomics approach was used to identify proteins that evade stress-induced translational repression in arsenite-treated cells expressing either wild-type or amyotrophic lateral sclerosis (ALS)-linked mutant FUS.	arsenite	147-155	FUS RNA binding protein	Homo sapiens	251-254
31187253-8	2019	A significant up-regulation of p-p5315 and p-p53392 can be observed when cells were exposed to arsenite at 5 mumol L-1 level for 24 h. Graphical abstract Schematic presentation of the ICP-MS immunoassay using apoferritin templated europium (III) and lutetium (III) phosphate nanoparticles as labels for the simultaneous determination of two phosphorylated p53 proteins.	arsenite	95-103	transformation related protein 53, pseudogene	Mus musculus	33-36
31009485-0	2019	Arsenite malignantly transforms human prostate epithelial cells in vitro by gene amplification of mutated KRAS.	arsenite	0-8	KRAS proto-oncogene, GTPase	Homo sapiens	106-110
30776335-1	2019	The yeast plasma membrane transporter Acr3 mediates efflux of toxic arsenite and antimonite.	arsenite	68-76	Arr3p	Saccharomyces cerevisiae S288C	38-42
31191509-0	2019	Arsenite Oxidation by a Newly Isolated Betaproteobacterium Possessing arx Genes and Diversity of the arx Gene Cluster in Bacterial Genomes.	arsenite	0-8	aristaless related homeobox	Homo sapiens	70-73
31191509-0	2019	Arsenite Oxidation by a Newly Isolated Betaproteobacterium Possessing arx Genes and Diversity of the arx Gene Cluster in Bacterial Genomes.	arsenite	0-8	aristaless related homeobox	Homo sapiens	101-104
31191509-2	2019	Microbial arsenite oxidation is catalyzed by either of two distantly related arsenite oxidases, referred to as AIO and ARX.	arsenite	10-18	aristaless related homeobox	Homo sapiens	119-122
30377756-6	2019	Our work has uncovered the mechanisms by which two stresses, arsenite treatment and DNA damage, stimulate the yeast SAPKs Hog1 and Mpk1, respectively.	arsenite	61-69	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	122-126
30853299-4	2019	Cytosolic liquid droplets of TDP-43 accumulate phosphorylated TDP-43 and rapidly convert into gels/solids in response to transient, arsenite-mediated stress.	arsenite	132-140	TAR DNA binding protein	Homo sapiens	29-35
30377756-6	2019	Our work has uncovered the mechanisms by which two stresses, arsenite treatment and DNA damage, stimulate the yeast SAPKs Hog1 and Mpk1, respectively.	arsenite	61-69	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	131-135
30782598-2	2019	The Nrf2 homolog SKN-1 functions in the intestinal cells nonautonomously to negatively regulate neuromuscular junction (NMJ) function in Caenorhabditis elegans To identify additional molecules that mediate SKN-1 signaling to the NMJ, we performed a candidate screen for suppressors of aldicarb resistance caused by acute treatment with the SKN-1 activator arsenite.	arsenite	356-364	NFE2 like bZIP transcription factor 2	Homo sapiens	4-8
30782598-2	2019	The Nrf2 homolog SKN-1 functions in the intestinal cells nonautonomously to negatively regulate neuromuscular junction (NMJ) function in Caenorhabditis elegans To identify additional molecules that mediate SKN-1 signaling to the NMJ, we performed a candidate screen for suppressors of aldicarb resistance caused by acute treatment with the SKN-1 activator arsenite.	arsenite	356-364	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	17-22
30782598-2	2019	The Nrf2 homolog SKN-1 functions in the intestinal cells nonautonomously to negatively regulate neuromuscular junction (NMJ) function in Caenorhabditis elegans To identify additional molecules that mediate SKN-1 signaling to the NMJ, we performed a candidate screen for suppressors of aldicarb resistance caused by acute treatment with the SKN-1 activator arsenite.	arsenite	356-364	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	206-211
30782598-2	2019	The Nrf2 homolog SKN-1 functions in the intestinal cells nonautonomously to negatively regulate neuromuscular junction (NMJ) function in Caenorhabditis elegans To identify additional molecules that mediate SKN-1 signaling to the NMJ, we performed a candidate screen for suppressors of aldicarb resistance caused by acute treatment with the SKN-1 activator arsenite.	arsenite	356-364	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	206-211
30654086-6	2019	Our results demonstrated that the treatment of human HaCaT cells with low levels of arsenite up-regulated m6A modification as well as its methyltransferases (METTL3/METTL14/WTAP) and inactivated the demethylase (FTO), exerting "protective response" against oxidative stress and promoting HaCaT cells survival.	arsenite	84-92	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	158-164
30654086-6	2019	Our results demonstrated that the treatment of human HaCaT cells with low levels of arsenite up-regulated m6A modification as well as its methyltransferases (METTL3/METTL14/WTAP) and inactivated the demethylase (FTO), exerting "protective response" against oxidative stress and promoting HaCaT cells survival.	arsenite	84-92	methyltransferase 14, N6-adenosine-methyltransferase subunit	Homo sapiens	165-172
30654086-6	2019	Our results demonstrated that the treatment of human HaCaT cells with low levels of arsenite up-regulated m6A modification as well as its methyltransferases (METTL3/METTL14/WTAP) and inactivated the demethylase (FTO), exerting "protective response" against oxidative stress and promoting HaCaT cells survival.	arsenite	84-92	WT1 associated protein	Homo sapiens	173-177
30654086-6	2019	Our results demonstrated that the treatment of human HaCaT cells with low levels of arsenite up-regulated m6A modification as well as its methyltransferases (METTL3/METTL14/WTAP) and inactivated the demethylase (FTO), exerting "protective response" against oxidative stress and promoting HaCaT cells survival.	arsenite	84-92	methyl-CpG binding domain protein 2	Homo sapiens	199-210
30654086-6	2019	Our results demonstrated that the treatment of human HaCaT cells with low levels of arsenite up-regulated m6A modification as well as its methyltransferases (METTL3/METTL14/WTAP) and inactivated the demethylase (FTO), exerting "protective response" against oxidative stress and promoting HaCaT cells survival.	arsenite	84-92	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	212-215
30735369-6	2019	Finally, we apply UCK2-mediated RNA labeling with 5-AmU to study RNA trafficking and turnover during normal and stress conditions and find diminished RNA localization in the cytosol during arsenite stress.	arsenite	189-197	uridine-cytidine kinase 2	Homo sapiens	18-22
30643918-0	2019	Regulation of gasdermin D by miR-379-5p is involved in arsenite-induced activation of hepatic stellate cells and in fibrosis via secretion of IL-1beta from human hepatic cells.	arsenite	55-63	gasdermin D	Homo sapiens	14-25
30643918-0	2019	Regulation of gasdermin D by miR-379-5p is involved in arsenite-induced activation of hepatic stellate cells and in fibrosis via secretion of IL-1beta from human hepatic cells.	arsenite	55-63	microRNA 379	Homo sapiens	29-36
30643918-0	2019	Regulation of gasdermin D by miR-379-5p is involved in arsenite-induced activation of hepatic stellate cells and in fibrosis via secretion of IL-1beta from human hepatic cells.	arsenite	55-63	interleukin 1 alpha	Homo sapiens	142-150
30643918-5	2019	In L-02 cells, arsenite caused increases of GSDMD and cleaved caspase-1 levels and decreases of caspase-1 and miR-379-5p levels.	arsenite	15-23	gasdermin D	Homo sapiens	44-49
30643918-5	2019	In L-02 cells, arsenite caused increases of GSDMD and cleaved caspase-1 levels and decreases of caspase-1 and miR-379-5p levels.	arsenite	15-23	caspase 1	Homo sapiens	62-71
30643918-5	2019	In L-02 cells, arsenite caused increases of GSDMD and cleaved caspase-1 levels and decreases of caspase-1 and miR-379-5p levels.	arsenite	15-23	caspase 1	Homo sapiens	96-105
30643918-5	2019	In L-02 cells, arsenite caused increases of GSDMD and cleaved caspase-1 levels and decreases of caspase-1 and miR-379-5p levels.	arsenite	15-23	microRNA 379	Homo sapiens	110-117
30643918-8	2019	In L-02 cells, the over-expression of miR-379-5p blocked the arsenite-induced increases of GSDMD levels and the release of IL-1beta, effects that were reversed by up-regulation of GSDMD.	arsenite	61-69	microRNA 379	Homo sapiens	38-45
30643918-8	2019	In L-02 cells, the over-expression of miR-379-5p blocked the arsenite-induced increases of GSDMD levels and the release of IL-1beta, effects that were reversed by up-regulation of GSDMD.	arsenite	61-69	gasdermin D	Homo sapiens	91-96
30643918-8	2019	In L-02 cells, the over-expression of miR-379-5p blocked the arsenite-induced increases of GSDMD levels and the release of IL-1beta, effects that were reversed by up-regulation of GSDMD.	arsenite	61-69	interleukin 1 alpha	Homo sapiens	123-131
30643918-8	2019	In L-02 cells, the over-expression of miR-379-5p blocked the arsenite-induced increases of GSDMD levels and the release of IL-1beta, effects that were reversed by up-regulation of GSDMD.	arsenite	61-69	gasdermin D	Homo sapiens	180-185
30643918-9	2019	LX-2 cells, cultured in the media from arsenite-treated L-02 cells, showed elevated levels of proliferating cell nuclear antigen (PCNA), collagen I, vimentin, and alpha-smooth muscle actin (alpha-SMA), which indicated activation of these cells.	arsenite	39-47	proliferating cell nuclear antigen	Homo sapiens	94-128
30643918-9	2019	LX-2 cells, cultured in the media from arsenite-treated L-02 cells, showed elevated levels of proliferating cell nuclear antigen (PCNA), collagen I, vimentin, and alpha-smooth muscle actin (alpha-SMA), which indicated activation of these cells.	arsenite	39-47	proliferating cell nuclear antigen	Homo sapiens	130-134
30643918-9	2019	LX-2 cells, cultured in the media from arsenite-treated L-02 cells, showed elevated levels of proliferating cell nuclear antigen (PCNA), collagen I, vimentin, and alpha-smooth muscle actin (alpha-SMA), which indicated activation of these cells.	arsenite	39-47	vimentin	Homo sapiens	149-157
30643918-9	2019	LX-2 cells, cultured in the media from arsenite-treated L-02 cells, showed elevated levels of proliferating cell nuclear antigen (PCNA), collagen I, vimentin, and alpha-smooth muscle actin (alpha-SMA), which indicated activation of these cells.	arsenite	39-47	actin alpha 1, skeletal muscle	Homo sapiens	190-199
30643918-10	2019	Activation of LX-2 cells by media from arsenite-treated L-02 cells was inhibited by IL-1beta neutralizing antibody.	arsenite	39-47	interleukin 1 alpha	Homo sapiens	84-92
30643918-11	2019	The media from arsenite-treated L-02 cells transfected with an miR-379-5p mimic inhibited the activation of LX-2 cells, a process that was reversed by up-regulation of GSDMD and by co-treatment with human recombinant IL-1beta.	arsenite	15-23	microRNA 379	Homo sapiens	63-70
31468445-7	2019	Taurine also reversed the arsenite-induced increase in caspase-3 activity.	arsenite	26-34	caspase 3	Homo sapiens	55-64
31468445-8	2019	The decrease in p-Akt levels induced by arsenite exposure was prevented by taurine treatment.	arsenite	40-48	AKT serine/threonine kinase 1	Homo sapiens	18-21
31468445-9	2019	Thus, taurine attenuated the effect of arsenite on primary cortical neurons, an effect that may involve the Akt pathway.	arsenite	39-47	AKT serine/threonine kinase 1	Homo sapiens	108-111
30404558-6	2019	In non-RNAi cells, arsenite induced the accumulation of Ago2 in SGs as shown by its colocalization and coimmunoprecipitation with SG proteins, but Ago2 was not recruited to SG in the cells with RNAi.	arsenite	19-27	argonaute RISC catalytic component 2	Homo sapiens	56-60
30404558-7	2019	Consistently, arsenite induced the dissociation of Ago2 from RISC proteins in non-RNAi cells but not in RNAi cells.	arsenite	14-22	argonaute RISC catalytic component 2	Homo sapiens	51-55
30404558-8	2019	CRISPR-Cas9-medicated ablation of Ago2 attenuated SG formation during arsenite treatment, suggesting a critical role of Ago2 in SG assembly.	arsenite	70-78	argonaute RISC catalytic component 2	Homo sapiens	34-38
30578631-3	2019	Here, we show that ISR activation by arsenite (Ar) results in suppression of IL-1beta production in macrophages and inhibition of DSS-induced colitis in a murine model through a novel posttranscriptional and translation regulatory (PTR) mechanism.	arsenite	37-45	interleukin 1 alpha	Mus musculus	77-85
30578631-3	2019	Here, we show that ISR activation by arsenite (Ar) results in suppression of IL-1beta production in macrophages and inhibition of DSS-induced colitis in a murine model through a novel posttranscriptional and translation regulatory (PTR) mechanism.	arsenite	47-49	interleukin 1 alpha	Mus musculus	77-85
30687352-3	2018	Here we describe a unique and specific interaction of SYP51 with an ER aquaporin, AtNIP1;1 (also known as NLM1) indicated to be able to transport arsenite [As(III)] and previously localized on PM.	arsenite	146-154	syntaxin of plants 51	Arabidopsis thaliana	54-59
30687352-3	2018	Here we describe a unique and specific interaction of SYP51 with an ER aquaporin, AtNIP1;1 (also known as NLM1) indicated to be able to transport arsenite [As(III)] and previously localized on PM.	arsenite	146-154	NOD26-like major intrinsic protein 1	Arabidopsis thaliana	82-90
30687352-3	2018	Here we describe a unique and specific interaction of SYP51 with an ER aquaporin, AtNIP1;1 (also known as NLM1) indicated to be able to transport arsenite [As(III)] and previously localized on PM.	arsenite	146-154	NOD26-like major intrinsic protein 1	Arabidopsis thaliana	106-110
30687352-7	2018	We also demonstrate that NIP1;1 is important for plant tolerance to arsenite but does not alter its uptake or translocation.	arsenite	68-76	NEP-interacting protein 1	Arabidopsis thaliana	25-29
30687352-8	2018	To explain such phenomenon the hypothesis that SYP51/NIP1;1 interaction modifies ER and vacuole ability to accumulate arsenite is discussed.	arsenite	118-126	syntaxin of plants 51	Arabidopsis thaliana	47-52
30687352-8	2018	To explain such phenomenon the hypothesis that SYP51/NIP1;1 interaction modifies ER and vacuole ability to accumulate arsenite is discussed.	arsenite	118-126	NEP-interacting protein 1	Arabidopsis thaliana	53-57
30726814-0	2019	Arsenite suppresses NO production evoked by lipopolysaccharide and poly(I:C) via the suppression of interferon-beta expression in RAW264.7 cells.	arsenite	0-8	interferon beta 1, fibroblast	Mus musculus	100-115
31708534-4	2019	The effect of arsenite in the expressions of different components of NMDAR (NR1, NR2A, NR2B) and AMPAR (GluR1, GluR2, GluR3), including calcium/calmodulin-dependent protein kinase II (CaMKII) and phosphorylated-CaMKII (p-CaMKII), at PND 7, 14, 21 and 35 was estimated and analyzed from the hippocampus of mice.	arsenite	14-22	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	69-74
31708534-4	2019	The effect of arsenite in the expressions of different components of NMDAR (NR1, NR2A, NR2B) and AMPAR (GluR1, GluR2, GluR3), including calcium/calmodulin-dependent protein kinase II (CaMKII) and phosphorylated-CaMKII (p-CaMKII), at PND 7, 14, 21 and 35 was estimated and analyzed from the hippocampus of mice.	arsenite	14-22	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	76-79
31708534-4	2019	The effect of arsenite in the expressions of different components of NMDAR (NR1, NR2A, NR2B) and AMPAR (GluR1, GluR2, GluR3), including calcium/calmodulin-dependent protein kinase II (CaMKII) and phosphorylated-CaMKII (p-CaMKII), at PND 7, 14, 21 and 35 was estimated and analyzed from the hippocampus of mice.	arsenite	14-22	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	81-85
31708534-4	2019	The effect of arsenite in the expressions of different components of NMDAR (NR1, NR2A, NR2B) and AMPAR (GluR1, GluR2, GluR3), including calcium/calmodulin-dependent protein kinase II (CaMKII) and phosphorylated-CaMKII (p-CaMKII), at PND 7, 14, 21 and 35 was estimated and analyzed from the hippocampus of mice.	arsenite	14-22	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	87-91
31708534-4	2019	The effect of arsenite in the expressions of different components of NMDAR (NR1, NR2A, NR2B) and AMPAR (GluR1, GluR2, GluR3), including calcium/calmodulin-dependent protein kinase II (CaMKII) and phosphorylated-CaMKII (p-CaMKII), at PND 7, 14, 21 and 35 was estimated and analyzed from the hippocampus of mice.	arsenite	14-22	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	104-109
31708534-5	2019	A significant inhibition in the protein and mRNA expressions of NR1, NR2A, NR2B and GluR1 was observed in mice exposed to 50 mg/L arsenite since PND 7.	arsenite	130-138	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	64-67
31708534-5	2019	A significant inhibition in the protein and mRNA expressions of NR1, NR2A, NR2B and GluR1 was observed in mice exposed to 50 mg/L arsenite since PND 7.	arsenite	130-138	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	69-73
31708534-5	2019	A significant inhibition in the protein and mRNA expressions of NR1, NR2A, NR2B and GluR1 was observed in mice exposed to 50 mg/L arsenite since PND 7.	arsenite	130-138	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	75-79
31708534-5	2019	A significant inhibition in the protein and mRNA expressions of NR1, NR2A, NR2B and GluR1 was observed in mice exposed to 50 mg/L arsenite since PND 7.	arsenite	130-138	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	84-89
31708534-6	2019	Down regulation of GluR2 and GluR3 both at mRNA and protein levels was observed in mice exposed to 50 mg/L arsenite till PND 14.	arsenite	107-115	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	19-24
31708534-6	2019	Down regulation of GluR2 and GluR3 both at mRNA and protein levels was observed in mice exposed to 50 mg/L arsenite till PND 14.	arsenite	107-115	glutamate receptor, ionotropic, AMPA3 (alpha 3)	Mus musculus	29-34
31708534-7	2019	Moreover, both CaMKII as well as p-CaMKII expressions were significantly limited since PND 7 in 50 mg/L arsenite exposed mice group.	arsenite	104-112	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	15-21
31708534-7	2019	Moreover, both CaMKII as well as p-CaMKII expressions were significantly limited since PND 7 in 50 mg/L arsenite exposed mice group.	arsenite	104-112	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	35-41
31708534-8	2019	Findings form this study suggested that the previously reported impairment in learning and memorizing abilities in later stage due to early life arsenite exposure is associated with the alterations of NMDARs, AMPARs, CaMKII and p-CaMKII expressions.	arsenite	145-153	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	209-215
31708534-8	2019	Findings form this study suggested that the previously reported impairment in learning and memorizing abilities in later stage due to early life arsenite exposure is associated with the alterations of NMDARs, AMPARs, CaMKII and p-CaMKII expressions.	arsenite	145-153	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	217-223
31708534-8	2019	Findings form this study suggested that the previously reported impairment in learning and memorizing abilities in later stage due to early life arsenite exposure is associated with the alterations of NMDARs, AMPARs, CaMKII and p-CaMKII expressions.	arsenite	145-153	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	230-236
30643918-11	2019	The media from arsenite-treated L-02 cells transfected with an miR-379-5p mimic inhibited the activation of LX-2 cells, a process that was reversed by up-regulation of GSDMD and by co-treatment with human recombinant IL-1beta.	arsenite	15-23	gasdermin D	Homo sapiens	168-173
30643918-11	2019	The media from arsenite-treated L-02 cells transfected with an miR-379-5p mimic inhibited the activation of LX-2 cells, a process that was reversed by up-regulation of GSDMD and by co-treatment with human recombinant IL-1beta.	arsenite	15-23	interleukin 1 alpha	Homo sapiens	217-225
30643918-13	2019	In liver tissue of arsenite-exposed mice, the levels of miR-379-5p were lower, but the levels of GSDMD and cleaved caspase-1 were elevated, and in sera from arsenite-exposed mice, the IL-1beta levels were elevated.	arsenite	19-27	microRNA 379	Mus musculus	56-63
30643918-13	2019	In liver tissue of arsenite-exposed mice, the levels of miR-379-5p were lower, but the levels of GSDMD and cleaved caspase-1 were elevated, and in sera from arsenite-exposed mice, the IL-1beta levels were elevated.	arsenite	19-27	gasdermin D	Mus musculus	97-102
30643918-13	2019	In liver tissue of arsenite-exposed mice, the levels of miR-379-5p were lower, but the levels of GSDMD and cleaved caspase-1 were elevated, and in sera from arsenite-exposed mice, the IL-1beta levels were elevated.	arsenite	19-27	caspase 1	Mus musculus	115-124
30643918-13	2019	In liver tissue of arsenite-exposed mice, the levels of miR-379-5p were lower, but the levels of GSDMD and cleaved caspase-1 were elevated, and in sera from arsenite-exposed mice, the IL-1beta levels were elevated.	arsenite	19-27	interleukin 1 alpha	Mus musculus	184-192
30643918-13	2019	In liver tissue of arsenite-exposed mice, the levels of miR-379-5p were lower, but the levels of GSDMD and cleaved caspase-1 were elevated, and in sera from arsenite-exposed mice, the IL-1beta levels were elevated.	arsenite	157-165	gasdermin D	Mus musculus	97-102
30643918-13	2019	In liver tissue of arsenite-exposed mice, the levels of miR-379-5p were lower, but the levels of GSDMD and cleaved caspase-1 were elevated, and in sera from arsenite-exposed mice, the IL-1beta levels were elevated.	arsenite	157-165	caspase 1	Mus musculus	115-124
30643918-13	2019	In liver tissue of arsenite-exposed mice, the levels of miR-379-5p were lower, but the levels of GSDMD and cleaved caspase-1 were elevated, and in sera from arsenite-exposed mice, the IL-1beta levels were elevated.	arsenite	157-165	interleukin 1 alpha	Mus musculus	184-192
30643918-14	2019	These results indicate that, by elevating the secretion of IL-1beta, miR-379-5p regulation of GSDMD is involved in arsenite-induced activation of HSCs and in hepatic fibrosis.	arsenite	115-123	interleukin 1 alpha	Mus musculus	59-67
30643918-14	2019	These results indicate that, by elevating the secretion of IL-1beta, miR-379-5p regulation of GSDMD is involved in arsenite-induced activation of HSCs and in hepatic fibrosis.	arsenite	115-123	microRNA 379	Mus musculus	69-76
30643918-14	2019	These results indicate that, by elevating the secretion of IL-1beta, miR-379-5p regulation of GSDMD is involved in arsenite-induced activation of HSCs and in hepatic fibrosis.	arsenite	115-123	gasdermin D	Homo sapiens	94-99
30177839-0	2019	Transcriptional repression of IKKbeta by p53 in arsenite-induced GADD45alpha accumulation and apoptosis.	arsenite	48-56	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	30-37
30177839-4	2019	Arsenite stimulation induced transactivation of p53, which formed a complex with its downstream target, Ets-1, and then synergistically repressed IKKbeta transcription, reduced MDM2 stability, and ultimately removed the inhibitory effect of MDM2 on GADD45alpha induction.	arsenite	0-8	growth arrest and DNA damage inducible alpha	Homo sapiens	249-260
29889593-3	2019	In this present study, two gram-positive rod-shaped bacteria were isolated from shallow aquifers of Bhojpur district in Bihar during the early winter season, able to withstand arsenite (As3+) concentration upto 70 mM and 1000 mM of arsenate (As5+) concentration.	arsenite	176-184	PDS5 cohesin associated factor B	Homo sapiens	186-189
30261343-6	2019	FOXO1 nuclear exclusion elicited by insulin or xenobiotics such as arsenite or copper ions was attenuated by DEM, suggesting that DEM interfered with nuclear export.	arsenite	67-75	forkhead box O1	Homo sapiens	0-5
30261343-6	2019	FOXO1 nuclear exclusion elicited by insulin or xenobiotics such as arsenite or copper ions was attenuated by DEM, suggesting that DEM interfered with nuclear export.	arsenite	67-75	insulin	Homo sapiens	36-43
30388683-0	2019	Calcium signals between the ryanodine receptor- and mitochondria critically regulate the effects of arsenite on mitochondrial superoxide formation and on the ensuing survival vs apoptotic signaling.	arsenite	100-108	ryanodine receptor 1	Homo sapiens	28-46
30388683-1	2019	A low concentration of arsenite (6 h), selectively stimulating the intraluminal crosstalk between the inositol-1, 4, 5-triphosphate receptor and the ryanodine receptor (RyR), increased the mitochondrial transport of RyR-derived Ca2+ through the mitochondrial Ca2+ uniporter.	arsenite	23-31	ryanodine receptor 1	Homo sapiens	149-167
30388683-1	2019	A low concentration of arsenite (6 h), selectively stimulating the intraluminal crosstalk between the inositol-1, 4, 5-triphosphate receptor and the ryanodine receptor (RyR), increased the mitochondrial transport of RyR-derived Ca2+ through the mitochondrial Ca2+ uniporter.	arsenite	23-31	ryanodine receptor 1	Homo sapiens	169-172
30388683-1	2019	A low concentration of arsenite (6 h), selectively stimulating the intraluminal crosstalk between the inositol-1, 4, 5-triphosphate receptor and the ryanodine receptor (RyR), increased the mitochondrial transport of RyR-derived Ca2+ through the mitochondrial Ca2+ uniporter.	arsenite	23-31	ryanodine receptor 1	Homo sapiens	216-219
30388683-3	2019	Inhibition of mitochondrial Ca2+ accumulation therefore prevented the effects of arsenite, in both the mitochondrial (e.g., cardiolipin oxidation) and extramitochondrial (e.g., DNA single- strand breakage) compartments, and suppressed the Nrf2/GSH survival signaling.	arsenite	81-89	NFE2 like bZIP transcription factor 2	Homo sapiens	239-243
30388683-8	2019	In conclusion, we report that the fraction of Ca2+ taken up by the mitochondria in response to arsenite derives from the RyR.	arsenite	95-103	ryanodine receptor 1	Homo sapiens	121-124
29905828-0	2019	miR-149 Negative Regulation of mafA Is Involved in the Arsenite-Induced Dysfunction of Insulin Synthesis and Secretion in Pancreatic Beta Cells.	arsenite	55-63	microRNA 149	Mus musculus	0-7
29905828-0	2019	miR-149 Negative Regulation of mafA Is Involved in the Arsenite-Induced Dysfunction of Insulin Synthesis and Secretion in Pancreatic Beta Cells.	arsenite	55-63	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)	Mus musculus	31-35
29905828-3	2019	After CD1 mice were treated with 20 or 40 ppm arsenite in the drinking water for 12 months, the mice showed reduced fasting insulin levels, a depression in glucose clearance, and lower insulin content in the pancreas.	arsenite	46-54	CD1 antigen complex	Mus musculus	6-9
29905828-7	2019	Since microRNAs (miRNAs) are involved in pancreatic beta-cell function and the pathogenesis of diabetes, we hypothesized that arsenite exposure activates miR-149, decreases insulin transcription factor v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (mafA), and induces an insulin synthesis and secretion disorder.	arsenite	126-134	microRNA 149	Mus musculus	154-161
29905828-7	2019	Since microRNAs (miRNAs) are involved in pancreatic beta-cell function and the pathogenesis of diabetes, we hypothesized that arsenite exposure activates miR-149, decreases insulin transcription factor v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (mafA), and induces an insulin synthesis and secretion disorder.	arsenite	126-134	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)	Mus musculus	202-258
29905828-7	2019	Since microRNAs (miRNAs) are involved in pancreatic beta-cell function and the pathogenesis of diabetes, we hypothesized that arsenite exposure activates miR-149, decreases insulin transcription factor v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (mafA), and induces an insulin synthesis and secretion disorder.	arsenite	126-134	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)	Mus musculus	260-264
29905828-8	2019	In arsenite-exposed Min6 cells, mafA activity was lowered by the increase of its target miRNA, miR-149.	arsenite	3-11	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)	Mus musculus	32-36
29905828-8	2019	In arsenite-exposed Min6 cells, mafA activity was lowered by the increase of its target miRNA, miR-149.	arsenite	3-11	microRNA 149	Mus musculus	95-102
29905828-11	2019	In control cells, however, arsenite decreased GSIS or mafA expression.	arsenite	27-35	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)	Mus musculus	54-58
29905828-12	2019	Our results suggest that low levels of arsenite affect beta-cell function and regulate insulin synthesis and secretion by modulating mafA expression through miR-149.	arsenite	39-47	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)	Mus musculus	133-137
29905828-12	2019	Our results suggest that low levels of arsenite affect beta-cell function and regulate insulin synthesis and secretion by modulating mafA expression through miR-149.	arsenite	39-47	microRNA 149	Mus musculus	157-164
30278210-7	2019	Furthermore, arsenite could induce G2/M phase arrest in testes, concurrent with a significant decrease in mRNA and protein levels of cdc2 and cyclin B1, the upregulation of p-cdc2, and an increase in mRNA levels of p53 and p21.	arsenite	13-21	cyclin-dependent kinase 1	Mus musculus	133-137
30278210-7	2019	Furthermore, arsenite could induce G2/M phase arrest in testes, concurrent with a significant decrease in mRNA and protein levels of cdc2 and cyclin B1, the upregulation of p-cdc2, and an increase in mRNA levels of p53 and p21.	arsenite	13-21	cyclin B1	Mus musculus	142-151
30278210-7	2019	Furthermore, arsenite could induce G2/M phase arrest in testes, concurrent with a significant decrease in mRNA and protein levels of cdc2 and cyclin B1, the upregulation of p-cdc2, and an increase in mRNA levels of p53 and p21.	arsenite	13-21	cyclin-dependent kinase 1	Mus musculus	175-179
30278210-7	2019	Furthermore, arsenite could induce G2/M phase arrest in testes, concurrent with a significant decrease in mRNA and protein levels of cdc2 and cyclin B1, the upregulation of p-cdc2, and an increase in mRNA levels of p53 and p21.	arsenite	13-21	transformation related protein 53, pseudogene	Mus musculus	215-218
30278210-7	2019	Furthermore, arsenite could induce G2/M phase arrest in testes, concurrent with a significant decrease in mRNA and protein levels of cdc2 and cyclin B1, the upregulation of p-cdc2, and an increase in mRNA levels of p53 and p21.	arsenite	13-21	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	223-226
30278210-8	2019	Arsenite induced testicular apoptosis with a significant increase in Bax mRNA and protein levels, especially the caspase-3 activation.	arsenite	0-8	BCL2-associated X protein	Mus musculus	69-72
30278210-8	2019	Arsenite induced testicular apoptosis with a significant increase in Bax mRNA and protein levels, especially the caspase-3 activation.	arsenite	0-8	caspase 3	Mus musculus	113-122
30177839-6	2019	Subsequent studies further revealed that the activation of the DAPK1/p53/Ets-1/IKKbeta/MDM2/GADD45alpha cascade was a common signaling event in mediating apoptosis of diverse cancer cells induced by arsenite and other tumor therapeutic agents.	arsenite	199-207	death associated protein kinase 1	Homo sapiens	63-68
30177839-6	2019	Subsequent studies further revealed that the activation of the DAPK1/p53/Ets-1/IKKbeta/MDM2/GADD45alpha cascade was a common signaling event in mediating apoptosis of diverse cancer cells induced by arsenite and other tumor therapeutic agents.	arsenite	199-207	tumor protein p53	Homo sapiens	69-72
30177839-6	2019	Subsequent studies further revealed that the activation of the DAPK1/p53/Ets-1/IKKbeta/MDM2/GADD45alpha cascade was a common signaling event in mediating apoptosis of diverse cancer cells induced by arsenite and other tumor therapeutic agents.	arsenite	199-207	ETS proto-oncogene 1, transcription factor	Homo sapiens	73-78
30177839-6	2019	Subsequent studies further revealed that the activation of the DAPK1/p53/Ets-1/IKKbeta/MDM2/GADD45alpha cascade was a common signaling event in mediating apoptosis of diverse cancer cells induced by arsenite and other tumor therapeutic agents.	arsenite	199-207	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	79-86
30177839-6	2019	Subsequent studies further revealed that the activation of the DAPK1/p53/Ets-1/IKKbeta/MDM2/GADD45alpha cascade was a common signaling event in mediating apoptosis of diverse cancer cells induced by arsenite and other tumor therapeutic agents.	arsenite	199-207	MDM2 proto-oncogene	Homo sapiens	87-91
30177839-6	2019	Subsequent studies further revealed that the activation of the DAPK1/p53/Ets-1/IKKbeta/MDM2/GADD45alpha cascade was a common signaling event in mediating apoptosis of diverse cancer cells induced by arsenite and other tumor therapeutic agents.	arsenite	199-207	growth arrest and DNA damage inducible alpha	Homo sapiens	92-103
30177839-0	2019	Transcriptional repression of IKKbeta by p53 in arsenite-induced GADD45alpha accumulation and apoptosis.	arsenite	48-56	tumor protein p53	Homo sapiens	41-44
30177839-0	2019	Transcriptional repression of IKKbeta by p53 in arsenite-induced GADD45alpha accumulation and apoptosis.	arsenite	48-56	growth arrest and DNA damage inducible alpha	Homo sapiens	65-76
30177839-2	2019	Arsenite exposure induces ribosomal stress responses mediated by the ribosomal protein S7, which can block MDM2 activity and result in GADD45alpha accumulation and cell apoptosis.	arsenite	0-8	MDM2 proto-oncogene	Homo sapiens	107-111
30177839-2	2019	Arsenite exposure induces ribosomal stress responses mediated by the ribosomal protein S7, which can block MDM2 activity and result in GADD45alpha accumulation and cell apoptosis.	arsenite	0-8	growth arrest and DNA damage inducible alpha	Homo sapiens	135-146
30177839-4	2019	Arsenite stimulation induced transactivation of p53, which formed a complex with its downstream target, Ets-1, and then synergistically repressed IKKbeta transcription, reduced MDM2 stability, and ultimately removed the inhibitory effect of MDM2 on GADD45alpha induction.	arsenite	0-8	tumor protein p53	Homo sapiens	48-51
30177839-4	2019	Arsenite stimulation induced transactivation of p53, which formed a complex with its downstream target, Ets-1, and then synergistically repressed IKKbeta transcription, reduced MDM2 stability, and ultimately removed the inhibitory effect of MDM2 on GADD45alpha induction.	arsenite	0-8	ETS proto-oncogene 1, transcription factor	Homo sapiens	104-109
30177839-4	2019	Arsenite stimulation induced transactivation of p53, which formed a complex with its downstream target, Ets-1, and then synergistically repressed IKKbeta transcription, reduced MDM2 stability, and ultimately removed the inhibitory effect of MDM2 on GADD45alpha induction.	arsenite	0-8	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	146-153
30177839-4	2019	Arsenite stimulation induced transactivation of p53, which formed a complex with its downstream target, Ets-1, and then synergistically repressed IKKbeta transcription, reduced MDM2 stability, and ultimately removed the inhibitory effect of MDM2 on GADD45alpha induction.	arsenite	0-8	MDM2 proto-oncogene	Homo sapiens	177-181
30177839-4	2019	Arsenite stimulation induced transactivation of p53, which formed a complex with its downstream target, Ets-1, and then synergistically repressed IKKbeta transcription, reduced MDM2 stability, and ultimately removed the inhibitory effect of MDM2 on GADD45alpha induction.	arsenite	0-8	MDM2 proto-oncogene	Homo sapiens	241-245
29987898-7	2018	The results revealed significant decrease in testicular glutathione peroxidase, catalase and glutathione in arsenite-treated animals relative to controls.	arsenite	108-116	catalase	Rattus norvegicus	80-88
30309986-3	2018	Here, we analyzed the transcriptional up-regulation of HSF1 in human cells upon arsenite- or peroxide-induced oxidative stress.	arsenite	80-88	heat shock transcription factor 1	Homo sapiens	55-59
29987898-9	2018	Concurrent administration of betaine with arsenite significantly increased glutathione and catalase amounts in comparison with arsenite group.	arsenite	42-50	catalase	Rattus norvegicus	91-99
30376133-3	2018	We have previously shown that 200 ppb arsenite in the drinking water increased the atherosclerosis in apolipoprotein E knock-out (apoE-/-) mice after 13 weeks, but the effects of lower concentrations were unknown.	arsenite	38-46	apolipoprotein E	Mus musculus	102-118
30189257-0	2018	Functional suppression of macrophages derived from THP-1 cells by environmentally-relevant concentrations of arsenite.	arsenite	109-117	GLI family zinc finger 2	Homo sapiens	51-56
30189257-3	2018	In this study, we utilized the macrophages derived from the THP-1 human monocyte cell line as the experimental model to study the functional suppression induced by arsenite (As+3), one of the most prevalent forms of inorganic arsenic, at environmentally-relevant concentrations.	arsenite	164-172	GLI family zinc finger 2	Homo sapiens	60-65
30292834-0	2018	Solubility changes of promyelocytic leukemia (PML) and SUMO monomers and dynamics of PML nuclear body proteins in arsenite-treated cells.	arsenite	114-122	PML nuclear body scaffold	Homo sapiens	22-50
30292834-1	2018	Promyelocytic leukemia (PML) and a suite of other proteins form nuclear bodies (NBs) where SUMOylation of PML and tumor suppression events occur in response to arsenite (As3+) treatment.	arsenite	160-168	PML nuclear body scaffold	Homo sapiens	0-28
30292834-1	2018	Promyelocytic leukemia (PML) and a suite of other proteins form nuclear bodies (NBs) where SUMOylation of PML and tumor suppression events occur in response to arsenite (As3+) treatment.	arsenite	160-168	PML nuclear body scaffold	Homo sapiens	24-27
30442959-10	2018	tRF5-AlaCGC activates p65, subsequently leading to enhanced secretion of IL-8 in arsenite response.	arsenite	81-89	RELA proto-oncogene, NF-kB subunit	Homo sapiens	22-25
30442959-10	2018	tRF5-AlaCGC activates p65, subsequently leading to enhanced secretion of IL-8 in arsenite response.	arsenite	81-89	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
30278242-5	2018	Metabolism of arsenite to dimethylarsinate (DMAV) by arsenite-3-methyltransferase (As3MT) promotes clearance, but also generates reactive trivalent intermediates that bind extensively to cellular thiols.	arsenite	14-22	arsenite methyltransferase	Mus musculus	53-81
30278242-5	2018	Metabolism of arsenite to dimethylarsinate (DMAV) by arsenite-3-methyltransferase (As3MT) promotes clearance, but also generates reactive trivalent intermediates that bind extensively to cellular thiols.	arsenite	14-22	arsenite methyltransferase	Mus musculus	83-88
30137596-0	2018	HER2 Activation Factors in Arsenite-Exposed Bladder Epithelial Cells.	arsenite	27-35	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
30137596-3	2018	However, until this point, little is known about HER2 activation and its mechanism in arsenite-exposed urothelial cells.	arsenite	86-94	erb-b2 receptor tyrosine kinase 2	Homo sapiens	49-53
30137596-4	2018	The aim of this study was to identify factors associated with HER2 activation in an arsenite-exposed human bladder epithelial cell line.	arsenite	84-92	erb-b2 receptor tyrosine kinase 2	Homo sapiens	62-66
30137596-5	2018	Results of this study demonstrated that levels of phosphorylated HER2 increased significantly in cells treated with arsenite.	arsenite	116-124	erb-b2 receptor tyrosine kinase 2	Homo sapiens	65-69
30137596-8	2018	Pretreatment of arsenite-exposed cells with exogenous EGF, TGFalpha, NRG1, and HSP90 could promote, whereas exogenous IL-6 and NDRG1 could suppress, the phosphorylation of HER2.	arsenite	16-24	transforming growth factor alpha	Homo sapiens	59-67
30137596-8	2018	Pretreatment of arsenite-exposed cells with exogenous EGF, TGFalpha, NRG1, and HSP90 could promote, whereas exogenous IL-6 and NDRG1 could suppress, the phosphorylation of HER2.	arsenite	16-24	neuregulin 1	Homo sapiens	69-73
30137596-8	2018	Pretreatment of arsenite-exposed cells with exogenous EGF, TGFalpha, NRG1, and HSP90 could promote, whereas exogenous IL-6 and NDRG1 could suppress, the phosphorylation of HER2.	arsenite	16-24	heat shock protein 90 alpha family class A member 1	Homo sapiens	79-84
30137596-8	2018	Pretreatment of arsenite-exposed cells with exogenous EGF, TGFalpha, NRG1, and HSP90 could promote, whereas exogenous IL-6 and NDRG1 could suppress, the phosphorylation of HER2.	arsenite	16-24	interleukin 6	Homo sapiens	118-122
30137596-8	2018	Pretreatment of arsenite-exposed cells with exogenous EGF, TGFalpha, NRG1, and HSP90 could promote, whereas exogenous IL-6 and NDRG1 could suppress, the phosphorylation of HER2.	arsenite	16-24	N-myc downstream regulated 1	Homo sapiens	127-132
30137596-8	2018	Pretreatment of arsenite-exposed cells with exogenous EGF, TGFalpha, NRG1, and HSP90 could promote, whereas exogenous IL-6 and NDRG1 could suppress, the phosphorylation of HER2.	arsenite	16-24	erb-b2 receptor tyrosine kinase 2	Homo sapiens	172-176
30137596-10	2018	In conclusion, our results suggested that HER2 might be activated through promoting the dimerization of HER2 with other members of HER family, maintaining the stability of phosphorylated HER2, and attenuating the suppression of HER2 activation in arsenite-exposed cells.	arsenite	247-255	erb-b2 receptor tyrosine kinase 2	Homo sapiens	42-46
30137596-10	2018	In conclusion, our results suggested that HER2 might be activated through promoting the dimerization of HER2 with other members of HER family, maintaining the stability of phosphorylated HER2, and attenuating the suppression of HER2 activation in arsenite-exposed cells.	arsenite	247-255	erb-b2 receptor tyrosine kinase 2	Homo sapiens	104-108
30137596-10	2018	In conclusion, our results suggested that HER2 might be activated through promoting the dimerization of HER2 with other members of HER family, maintaining the stability of phosphorylated HER2, and attenuating the suppression of HER2 activation in arsenite-exposed cells.	arsenite	247-255	erb-b2 receptor tyrosine kinase 2	Homo sapiens	104-108
30137596-10	2018	In conclusion, our results suggested that HER2 might be activated through promoting the dimerization of HER2 with other members of HER family, maintaining the stability of phosphorylated HER2, and attenuating the suppression of HER2 activation in arsenite-exposed cells.	arsenite	247-255	erb-b2 receptor tyrosine kinase 2	Homo sapiens	104-108
30334557-3	2018	In the present study, chronic arsenite exposure (2 muM or 5 muM, 30 weeks) induced malignant transformation of HK-2 human renal epithelial cells as indicated by elevated colony formation (6.2- and 5.4-fold increase, respectively), secreted MMP-9 activity (10.1- and 11.3-fold increase, respectively) and proliferation rate (1.2- and 1.3-fold increase in 72 h, respectively).	arsenite	30-38	matrix metallopeptidase 9	Homo sapiens	240-245
30334557-5	2018	Overexpression of hypoxia-inducible factor 2alpha (HIF2alpha) and suppression of carnitine palmitoyltransferase 1A (CPT1A) were found at the level of mRNA (1.5- and 0.49-fold of control, respectively) and protein (4.0- and 0.28-fold of control, respectively) after exposure to 2 muM arsenite for 20 weeks.	arsenite	283-291	endothelial PAS domain protein 1	Homo sapiens	18-49
30334557-5	2018	Overexpression of hypoxia-inducible factor 2alpha (HIF2alpha) and suppression of carnitine palmitoyltransferase 1A (CPT1A) were found at the level of mRNA (1.5- and 0.49-fold of control, respectively) and protein (4.0- and 0.28-fold of control, respectively) after exposure to 2 muM arsenite for 20 weeks.	arsenite	283-291	endothelial PAS domain protein 1	Homo sapiens	51-60
30334557-5	2018	Overexpression of hypoxia-inducible factor 2alpha (HIF2alpha) and suppression of carnitine palmitoyltransferase 1A (CPT1A) were found at the level of mRNA (1.5- and 0.49-fold of control, respectively) and protein (4.0- and 0.28-fold of control, respectively) after exposure to 2 muM arsenite for 20 weeks.	arsenite	283-291	carnitine palmitoyltransferase 1A	Homo sapiens	81-114
30334557-5	2018	Overexpression of hypoxia-inducible factor 2alpha (HIF2alpha) and suppression of carnitine palmitoyltransferase 1A (CPT1A) were found at the level of mRNA (1.5- and 0.49-fold of control, respectively) and protein (4.0- and 0.28-fold of control, respectively) after exposure to 2 muM arsenite for 20 weeks.	arsenite	283-291	carnitine palmitoyltransferase 1A	Homo sapiens	116-121
30334557-6	2018	Silencing of HIF2alpha significantly attenuated arsenite-induced malignant phenotypes and lipid accumulation.	arsenite	48-56	endothelial PAS domain protein 1	Homo sapiens	13-22
30334557-12	2018	Moreover, the miR-182-5p/HIF2alpha pathway is indicated to be involved in malignant transformation of human renal epithelial cells under arsenite exposure.	arsenite	137-145	microRNA 182	Homo sapiens	14-21
30334557-12	2018	Moreover, the miR-182-5p/HIF2alpha pathway is indicated to be involved in malignant transformation of human renal epithelial cells under arsenite exposure.	arsenite	137-145	endothelial PAS domain protein 1	Homo sapiens	25-34
30376133-3	2018	We have previously shown that 200 ppb arsenite in the drinking water increased the atherosclerosis in apolipoprotein E knock-out (apoE-/-) mice after 13 weeks, but the effects of lower concentrations were unknown.	arsenite	38-46	apolipoprotein E	Mus musculus	130-138
30713663-0	2019	Arsenite-induced apoptosis can be attenuated via depletion of mTOR activity to restore autophagy.	arsenite	0-8	mechanistic target of rapamycin kinase	Homo sapiens	62-66
30713663-4	2019	The decline of cell viability is due to apoptotic death since arsenite treatment reduces Akt activity and the Bcl2 level but increases caspase 3 activity and the cytochrome c level.	arsenite	62-70	BCL2 apoptosis regulator	Homo sapiens	110-114
30713663-4	2019	The decline of cell viability is due to apoptotic death since arsenite treatment reduces Akt activity and the Bcl2 level but increases caspase 3 activity and the cytochrome c level.	arsenite	62-70	caspase 3	Homo sapiens	135-144
30713663-4	2019	The decline of cell viability is due to apoptotic death since arsenite treatment reduces Akt activity and the Bcl2 level but increases caspase 3 activity and the cytochrome c level.	arsenite	62-70	cytochrome c, somatic	Homo sapiens	162-174
30713663-6	2019	PTEN, the upstream negative regulator of Akt activity, was also reduced with arsenite treatment.	arsenite	77-85	phosphatase and tensin homolog	Homo sapiens	0-4
30713663-10	2019	With arsenite administration, the LC3 and p62 levels increased.	arsenite	5-13	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	34-37
30713663-10	2019	With arsenite administration, the LC3 and p62 levels increased.	arsenite	5-13	nucleoporin 62	Homo sapiens	42-45
30713663-14	2019	Similar to rapamycin treatment, the knockdown of mTOR expression also enhanced the viability of arsenite-treated cells.	arsenite	96-104	mechanistic target of rapamycin kinase	Homo sapiens	49-53
30713663-15	2019	Both rapamycin treatment and mTOR knockdown enhanced ERK activity further, but reduced JNK activity and the p62 level in arsenite-treated cells.	arsenite	121-129	mechanistic target of rapamycin kinase	Homo sapiens	29-33
30713663-15	2019	Both rapamycin treatment and mTOR knockdown enhanced ERK activity further, but reduced JNK activity and the p62 level in arsenite-treated cells.	arsenite	121-129	mitogen-activated protein kinase 8	Homo sapiens	87-90
30713663-15	2019	Both rapamycin treatment and mTOR knockdown enhanced ERK activity further, but reduced JNK activity and the p62 level in arsenite-treated cells.	arsenite	121-129	nucleoporin 62	Homo sapiens	108-111
30713663-17	2019	These results reveal the critical role of mTOR in regulating the cell fate of arsenite-exposed renal cells.	arsenite	78-86	mechanistic target of rapamycin kinase	Homo sapiens	42-46
30392315-8	2018	Conclusion: HIF-1alpha is involved in arsenite-induced EMT and malignant transformation of human liver epithelial cells via regulating Snail.	arsenite	38-46	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-22
32254866-6	2018	Under optimal conditions, the GO-gated aptasensing system exhibited good PGM responses relative to arsenite concentrations within the dynamic working range of 0.01-100 ng mL-1 (ppb) at a detection limit of 2.3 pg mL-1 (ppt).	arsenite	99-107	L1 cell adhesion molecule	Mus musculus	171-175
32254866-6	2018	Under optimal conditions, the GO-gated aptasensing system exhibited good PGM responses relative to arsenite concentrations within the dynamic working range of 0.01-100 ng mL-1 (ppb) at a detection limit of 2.3 pg mL-1 (ppt).	arsenite	99-107	L1 cell adhesion molecule	Mus musculus	213-217
30068729-0	2018	Low Concentrations of Arsenite Target the Intraluminal Inositol 1, 4, 5-Trisphosphate Receptor/Ryanodine Receptor Crosstalk to Significantly Elevate Intracellular Ca2.	arsenite	22-30	ryanodine receptor 1	Homo sapiens	95-113
30068729-4	2018	We therefore conclude that arsenite elevates the [Ca2+]i by directly targeting the IP3R and its intraluminal crosstalk with the RyR.	arsenite	27-35	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	83-87
30068729-4	2018	We therefore conclude that arsenite elevates the [Ca2+]i by directly targeting the IP3R and its intraluminal crosstalk with the RyR.	arsenite	27-35	ryanodine receptor 1	Homo sapiens	128-131
29705342-0	2018	miR-145 via targeting ERCC2 is involved in arsenite-induced DNA damage in human hepatic cells.	arsenite	43-51	microRNA 145	Homo sapiens	0-7
29705342-0	2018	miR-145 via targeting ERCC2 is involved in arsenite-induced DNA damage in human hepatic cells.	arsenite	43-51	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	22-27
29705342-6	2018	In L-02 cells, arsenite, an active form of arsenic, induced up-regulation of miR-145 and down-regulation of ERCC1 and ERCC2, and caused DNA damage.	arsenite	15-23	microRNA 145	Homo sapiens	77-84
29705342-6	2018	In L-02 cells, arsenite, an active form of arsenic, induced up-regulation of miR-145 and down-regulation of ERCC1 and ERCC2, and caused DNA damage.	arsenite	15-23	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	108-113
29705342-6	2018	In L-02 cells, arsenite, an active form of arsenic, induced up-regulation of miR-145 and down-regulation of ERCC1 and ERCC2, and caused DNA damage.	arsenite	15-23	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	118-123
29705342-7	2018	For L-02 cells, transfection with an miR-145 inhibitor prevented arsenite-induced DNA damage and decreased ERCC2 levels.	arsenite	65-73	microRNA 145	Homo sapiens	37-44
29705342-9	2018	The present results demonstrate that arsenite induces the over-expression of miR-145 and inhibits DNA repair via targeting ERCC2, thus promoting DNA damage.	arsenite	37-45	microRNA 145	Homo sapiens	77-84
29705342-9	2018	The present results demonstrate that arsenite induces the over-expression of miR-145 and inhibits DNA repair via targeting ERCC2, thus promoting DNA damage.	arsenite	37-45	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	123-128
29982692-0	2018	m6A Demethylase FTO Regulates Dopaminergic Neurotransmission Deficits Caused by Arsenite.	arsenite	80-88	fat mass and obesity associated	Mus musculus	16-19
29982692-6	2018	Our data demonstrated for the first time that arsenite remarkably increased m6A modification, and FTO possessed the ability to alleviate the deficits in dopaminergic neurotransmission in response to arsenite exposure.	arsenite	199-207	fat mass and obesity associated	Mus musculus	98-101
29982692-7	2018	Our findings not only provide valuable insight into the molecular neurotoxic pathogenesis of arsenite exposure, but are also the first evidence that regulation of FTO may be considered as a novel strategy for the prevention of arsenite-associated neurological disorders.	arsenite	227-235	fat mass and obesity associated	Mus musculus	163-166
30392315-8	2018	Conclusion: HIF-1alpha is involved in arsenite-induced EMT and malignant transformation of human liver epithelial cells via regulating Snail.	arsenite	38-46	snail family transcriptional repressor 1	Homo sapiens	135-140
30392315-0	2018	[Hypoxia-inducible factor-1alpha is involved in arsenite-induced epithelial-mesenchymal transition and malignant transformation of human liver epithelial cells via regulating Snail].	arsenite	48-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-32
30392315-0	2018	[Hypoxia-inducible factor-1alpha is involved in arsenite-induced epithelial-mesenchymal transition and malignant transformation of human liver epithelial cells via regulating Snail].	arsenite	48-56	snail family transcriptional repressor 1	Homo sapiens	175-180
30392315-1	2018	Objective: To investigate the role of hypoxia-inducible factor-1alpha (HIF-1alpha) in arsenite-induced epithelial-mesenchymal transition (EMT) and malignant transformation of human liver epithelial cells (L-02 cells).	arsenite	86-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	38-69
30392315-1	2018	Objective: To investigate the role of hypoxia-inducible factor-1alpha (HIF-1alpha) in arsenite-induced epithelial-mesenchymal transition (EMT) and malignant transformation of human liver epithelial cells (L-02 cells).	arsenite	86-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-81
30066004-0	2018	HER2 and Src co-regulate proliferation, migration and transformation by downstream signaling pathways in arsenite-treated human uroepithelial cells.	arsenite	105-113	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
30167605-0	2018	Circ008913, via miR-889 regulation of DAB2IP/ZEB1, is involved in the arsenite-induced acquisition of CSC-like properties by human keratinocytes in carcinogenesis.	arsenite	70-78	microRNA 889	Homo sapiens	16-23
30167605-0	2018	Circ008913, via miR-889 regulation of DAB2IP/ZEB1, is involved in the arsenite-induced acquisition of CSC-like properties by human keratinocytes in carcinogenesis.	arsenite	70-78	DAB2 interacting protein	Homo sapiens	38-44
30167605-0	2018	Circ008913, via miR-889 regulation of DAB2IP/ZEB1, is involved in the arsenite-induced acquisition of CSC-like properties by human keratinocytes in carcinogenesis.	arsenite	70-78	zinc finger E-box binding homeobox 1	Homo sapiens	45-49
30167605-6	2018	In HaCaT cells, arsenite induced increases of mRNA levels of the genes for cell-surface markers (k5 and CD34) of skin stem cells, decreases of DAB2IP, and increases of ZEB1.	arsenite	16-24	CD34 molecule	Homo sapiens	104-108
30167605-6	2018	In HaCaT cells, arsenite induced increases of mRNA levels of the genes for cell-surface markers (k5 and CD34) of skin stem cells, decreases of DAB2IP, and increases of ZEB1.	arsenite	16-24	DAB2 interacting protein	Homo sapiens	143-149
30167605-6	2018	In HaCaT cells, arsenite induced increases of mRNA levels of the genes for cell-surface markers (k5 and CD34) of skin stem cells, decreases of DAB2IP, and increases of ZEB1.	arsenite	16-24	zinc finger E-box binding homeobox 1	Homo sapiens	168-172
30167605-9	2018	These results suggest that, in HaCaT cells, arsenite decreases circ008913 levels, which act as a sponge for miR-889 and down-regulate the miR-889 target, DAB2IP, which, in turn, up-regulates ZEB1, increases mRNA levels of the cell-surface markers of skin stem cells, and is involved in arsenite-induced acquisition of CSC-like properties that lead to malignant transformation.	arsenite	44-52	microRNA 889	Homo sapiens	108-115
30167605-9	2018	These results suggest that, in HaCaT cells, arsenite decreases circ008913 levels, which act as a sponge for miR-889 and down-regulate the miR-889 target, DAB2IP, which, in turn, up-regulates ZEB1, increases mRNA levels of the cell-surface markers of skin stem cells, and is involved in arsenite-induced acquisition of CSC-like properties that lead to malignant transformation.	arsenite	44-52	microRNA 889	Homo sapiens	138-145
30167605-9	2018	These results suggest that, in HaCaT cells, arsenite decreases circ008913 levels, which act as a sponge for miR-889 and down-regulate the miR-889 target, DAB2IP, which, in turn, up-regulates ZEB1, increases mRNA levels of the cell-surface markers of skin stem cells, and is involved in arsenite-induced acquisition of CSC-like properties that lead to malignant transformation.	arsenite	44-52	DAB2 interacting protein	Homo sapiens	154-160
30167605-9	2018	These results suggest that, in HaCaT cells, arsenite decreases circ008913 levels, which act as a sponge for miR-889 and down-regulate the miR-889 target, DAB2IP, which, in turn, up-regulates ZEB1, increases mRNA levels of the cell-surface markers of skin stem cells, and is involved in arsenite-induced acquisition of CSC-like properties that lead to malignant transformation.	arsenite	44-52	zinc finger E-box binding homeobox 1	Homo sapiens	191-195
30167605-9	2018	These results suggest that, in HaCaT cells, arsenite decreases circ008913 levels, which act as a sponge for miR-889 and down-regulate the miR-889 target, DAB2IP, which, in turn, up-regulates ZEB1, increases mRNA levels of the cell-surface markers of skin stem cells, and is involved in arsenite-induced acquisition of CSC-like properties that lead to malignant transformation.	arsenite	286-294	DAB2 interacting protein	Homo sapiens	154-160
30167605-10	2018	The results also indicate that circ008913 functions as a competing endogenous RNA (ceRNA) for miR-889, which is involved in the arsenite-induced acquisition of CSC-like properties by regulation of DAB2IP and elucidate a previously unknown mechanism between arsenite-induced acquisition of CSC-like properties and carcinogenesis.	arsenite	128-136	microRNA 889	Homo sapiens	94-101
30167605-10	2018	The results also indicate that circ008913 functions as a competing endogenous RNA (ceRNA) for miR-889, which is involved in the arsenite-induced acquisition of CSC-like properties by regulation of DAB2IP and elucidate a previously unknown mechanism between arsenite-induced acquisition of CSC-like properties and carcinogenesis.	arsenite	128-136	DAB2 interacting protein	Homo sapiens	197-203
30167605-10	2018	The results also indicate that circ008913 functions as a competing endogenous RNA (ceRNA) for miR-889, which is involved in the arsenite-induced acquisition of CSC-like properties by regulation of DAB2IP and elucidate a previously unknown mechanism between arsenite-induced acquisition of CSC-like properties and carcinogenesis.	arsenite	257-265	microRNA 889	Homo sapiens	94-101
30108172-0	2018	Exposure to Arsenite in CD-1 Mice during Juvenile and Adult Stages: Effects on Intestinal Microbiota and Gut-Associated Immune Status.	arsenite	12-20	CD1 antigen complex	Mus musculus	24-28
30066004-0	2018	HER2 and Src co-regulate proliferation, migration and transformation by downstream signaling pathways in arsenite-treated human uroepithelial cells.	arsenite	105-113	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	9-12
30066004-4	2018	We found that the expression HER2 and Src were increased following chronic arsenite exposure in a time-dependent fashion.	arsenite	75-83	erb-b2 receptor tyrosine kinase 2	Homo sapiens	29-33
30066004-4	2018	We found that the expression HER2 and Src were increased following chronic arsenite exposure in a time-dependent fashion.	arsenite	75-83	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	38-41
30066004-5	2018	Chronic arsenite exposure also led to an upregulation of proliferation factors such as cyclin D1, COX2, PCNA, VEGF, and HIF-1alpha.	arsenite	8-16	cyclin D1	Homo sapiens	87-96
30066004-5	2018	Chronic arsenite exposure also led to an upregulation of proliferation factors such as cyclin D1, COX2, PCNA, VEGF, and HIF-1alpha.	arsenite	8-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-102
30066004-5	2018	Chronic arsenite exposure also led to an upregulation of proliferation factors such as cyclin D1, COX2, PCNA, VEGF, and HIF-1alpha.	arsenite	8-16	proliferating cell nuclear antigen	Homo sapiens	104-108
30066004-5	2018	Chronic arsenite exposure also led to an upregulation of proliferation factors such as cyclin D1, COX2, PCNA, VEGF, and HIF-1alpha.	arsenite	8-16	vascular endothelial growth factor A	Homo sapiens	110-114
30066004-5	2018	Chronic arsenite exposure also led to an upregulation of proliferation factors such as cyclin D1, COX2, PCNA, VEGF, and HIF-1alpha.	arsenite	8-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	120-130
30066004-6	2018	Furthermore, Ras/Raf/MAPK, PI3K/AKT, and JAK2/STAT3 signaling pathways were activated by arsenite treatment.	arsenite	89-97	zinc fingers and homeoboxes 2	Homo sapiens	17-20
30066004-6	2018	Furthermore, Ras/Raf/MAPK, PI3K/AKT, and JAK2/STAT3 signaling pathways were activated by arsenite treatment.	arsenite	89-97	AKT serine/threonine kinase 1	Homo sapiens	32-35
30066004-6	2018	Furthermore, Ras/Raf/MAPK, PI3K/AKT, and JAK2/STAT3 signaling pathways were activated by arsenite treatment.	arsenite	89-97	Janus kinase 2	Homo sapiens	41-45
30066004-6	2018	Furthermore, Ras/Raf/MAPK, PI3K/AKT, and JAK2/STAT3 signaling pathways were activated by arsenite treatment.	arsenite	89-97	signal transducer and activator of transcription 3	Homo sapiens	46-51
30066004-8	2018	In addition, downregulation of HER2 inhibited cell growth and migration properties of arsenite-treated cells.	arsenite	86-94	erb-b2 receptor tyrosine kinase 2	Homo sapiens	31-35
30066004-11	2018	These results suggest that HER2 and Src may play an important role in arsenite-induced transformation by multiple downstream signals pathways.	arsenite	70-78	erb-b2 receptor tyrosine kinase 2	Homo sapiens	27-31
30066004-11	2018	These results suggest that HER2 and Src may play an important role in arsenite-induced transformation by multiple downstream signals pathways.	arsenite	70-78	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	36-39
30186748-9	2018	Critically, HSF1-mediated UBC trans-activation upon arsenite exposure relies on transcription factor binding to previously mapped distal HSEs, as demonstrated to occur under proteasome inhibition.	arsenite	52-60	heat shock transcription factor 1	Homo sapiens	12-16
29680375-3	2018	Our results firstly demonstrated that m6A modification on RNA was significantly increased in arsenite-transformed cells and this modification may be synergistically regulated by methyltransferase-like 3 (METTL3), methyltransferase-like 14 (METTL14), Wilms tumor 1-associated protein (WTAP) and Fat mass and obesity-associated protein (FTO).	arsenite	93-101	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	38-41
29680375-3	2018	Our results firstly demonstrated that m6A modification on RNA was significantly increased in arsenite-transformed cells and this modification may be synergistically regulated by methyltransferase-like 3 (METTL3), methyltransferase-like 14 (METTL14), Wilms tumor 1-associated protein (WTAP) and Fat mass and obesity-associated protein (FTO).	arsenite	93-101	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	204-210
29680375-3	2018	Our results firstly demonstrated that m6A modification on RNA was significantly increased in arsenite-transformed cells and this modification may be synergistically regulated by methyltransferase-like 3 (METTL3), methyltransferase-like 14 (METTL14), Wilms tumor 1-associated protein (WTAP) and Fat mass and obesity-associated protein (FTO).	arsenite	93-101	methyltransferase 14, N6-adenosine-methyltransferase subunit	Homo sapiens	213-238
29680375-3	2018	Our results firstly demonstrated that m6A modification on RNA was significantly increased in arsenite-transformed cells and this modification may be synergistically regulated by methyltransferase-like 3 (METTL3), methyltransferase-like 14 (METTL14), Wilms tumor 1-associated protein (WTAP) and Fat mass and obesity-associated protein (FTO).	arsenite	93-101	methyltransferase 14, N6-adenosine-methyltransferase subunit	Homo sapiens	240-247
29680375-3	2018	Our results firstly demonstrated that m6A modification on RNA was significantly increased in arsenite-transformed cells and this modification may be synergistically regulated by methyltransferase-like 3 (METTL3), methyltransferase-like 14 (METTL14), Wilms tumor 1-associated protein (WTAP) and Fat mass and obesity-associated protein (FTO).	arsenite	93-101	WT1 associated protein	Homo sapiens	250-282
29680375-3	2018	Our results firstly demonstrated that m6A modification on RNA was significantly increased in arsenite-transformed cells and this modification may be synergistically regulated by methyltransferase-like 3 (METTL3), methyltransferase-like 14 (METTL14), Wilms tumor 1-associated protein (WTAP) and Fat mass and obesity-associated protein (FTO).	arsenite	93-101	WT1 associated protein	Homo sapiens	284-288
29680375-3	2018	Our results firstly demonstrated that m6A modification on RNA was significantly increased in arsenite-transformed cells and this modification may be synergistically regulated by methyltransferase-like 3 (METTL3), methyltransferase-like 14 (METTL14), Wilms tumor 1-associated protein (WTAP) and Fat mass and obesity-associated protein (FTO).	arsenite	93-101	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	294-333
29680375-3	2018	Our results firstly demonstrated that m6A modification on RNA was significantly increased in arsenite-transformed cells and this modification may be synergistically regulated by methyltransferase-like 3 (METTL3), methyltransferase-like 14 (METTL14), Wilms tumor 1-associated protein (WTAP) and Fat mass and obesity-associated protein (FTO).	arsenite	93-101	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	335-338
29680375-4	2018	In addition, knocking down of METTL3 in arsenite-transformed cells can dramatically reverse the malignant phenotype, which was manifested by lower percentages of clone and colony formation as well as higher rates of apoptotic induction.	arsenite	40-48	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	30-36
29680375-5	2018	Given the critical roles of miRNAs in cellular proliferation and apoptosis, miRNAs regulated by m6A in arsenite-transformed cells were analyzed by Venn diagram and KEGG pathway in this study.	arsenite	103-111	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	96-99
29680375-6	2018	The results showed that these m6A-mediated miRNAs can regulate pathways which are closely associated with cellular proliferation and apoptosis, implicating that these miRNAs may be the critical bridge by which m6A mediates dysregulation of cell survival and apoptosis in arsenite-transformed cells.	arsenite	271-279	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	30-33
29680375-6	2018	The results showed that these m6A-mediated miRNAs can regulate pathways which are closely associated with cellular proliferation and apoptosis, implicating that these miRNAs may be the critical bridge by which m6A mediates dysregulation of cell survival and apoptosis in arsenite-transformed cells.	arsenite	271-279	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	210-213
29680375-7	2018	Taken together, our results firstly demonstrated the significant role of m6A in the prevention of tumor occurrence and progression induced by arsenite.	arsenite	142-150	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	73-76
30186748-3	2018	Here, we determined the molecular players driving the UBC gene transcriptional response to arsenite treatment, mainly addressing the role of the nuclear factor-erythroid 2-related factor 2 (Nrf2)-mediated antioxidant pathway.	arsenite	91-99	ubiquitin C	Homo sapiens	54-57
30186748-3	2018	Here, we determined the molecular players driving the UBC gene transcriptional response to arsenite treatment, mainly addressing the role of the nuclear factor-erythroid 2-related factor 2 (Nrf2)-mediated antioxidant pathway.	arsenite	91-99	NFE2 like bZIP transcription factor 2	Homo sapiens	145-188
30186748-3	2018	Here, we determined the molecular players driving the UBC gene transcriptional response to arsenite treatment, mainly addressing the role of the nuclear factor-erythroid 2-related factor 2 (Nrf2)-mediated antioxidant pathway.	arsenite	91-99	NFE2 like bZIP transcription factor 2	Homo sapiens	190-194
30186748-4	2018	Exposure of HeLa cells to arsenite caused a time-dependent increase of UBC mRNA, while cell viability and proteasome activity were not affected.	arsenite	26-34	ubiquitin C	Homo sapiens	71-74
30186748-5	2018	Nuclear accumulation of HSF1 and Nrf2 transcription factors was detected upon both arsenite and MG132 treatment, while HSF2 nuclear levels increased in MG132-treated cells.	arsenite	83-91	heat shock transcription factor 1	Homo sapiens	24-28
30186748-5	2018	Nuclear accumulation of HSF1 and Nrf2 transcription factors was detected upon both arsenite and MG132 treatment, while HSF2 nuclear levels increased in MG132-treated cells.	arsenite	83-91	NFE2 like bZIP transcription factor 2	Homo sapiens	33-37
29945972-6	2018	We found that the mechanism of arsenite-stimulated TFEB and TFE3 activation instead involves protein phosphatase 2A (PP2A)-mediated dephosphorylation at Ser-211 and Ser-321, respectively.	arsenite	31-39	transcription factor EB	Homo sapiens	51-55
29945972-6	2018	We found that the mechanism of arsenite-stimulated TFEB and TFE3 activation instead involves protein phosphatase 2A (PP2A)-mediated dephosphorylation at Ser-211 and Ser-321, respectively.	arsenite	31-39	transcription factor binding to IGHM enhancer 3	Homo sapiens	60-64
29945972-6	2018	We found that the mechanism of arsenite-stimulated TFEB and TFE3 activation instead involves protein phosphatase 2A (PP2A)-mediated dephosphorylation at Ser-211 and Ser-321, respectively.	arsenite	31-39	protein phosphatase 2 phosphatase activator	Homo sapiens	101-115
29945972-6	2018	We found that the mechanism of arsenite-stimulated TFEB and TFE3 activation instead involves protein phosphatase 2A (PP2A)-mediated dephosphorylation at Ser-211 and Ser-321, respectively.	arsenite	31-39	protein phosphatase 2 phosphatase activator	Homo sapiens	117-121
29846136-0	2018	Intracellular mechanism by which arsenite activates the yeast stress MAPK Hog1.	arsenite	33-41	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	74-78
29846136-3	2018	In this study, we delineate the intracellular signaling pathway by which the trivalent toxic metalloid arsenite [As(III)] activates the yeast SAPK Hog1.	arsenite	103-111	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	147-151
30186748-9	2018	Critically, HSF1-mediated UBC trans-activation upon arsenite exposure relies on transcription factor binding to previously mapped distal HSEs, as demonstrated to occur under proteasome inhibition.	arsenite	52-60	ubiquitin C	Homo sapiens	26-29
29597085-6	2018	The adsorption equilibrium of arsenate and arsenite was respectively established in 24 and 4 h. The maximum adsorption capacities of As(V) and As(III) at pH 7.0 were 170.48 and 84.22 mg-As/g, respectively.	arsenite	43-51	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	133-138
29804830-0	2018	ZFAND1 Recruits p97 and the 26S Proteasome to Promote the Clearance of Arsenite-Induced Stress Granules.	arsenite	71-79	zinc finger AN1-type containing 1	Homo sapiens	0-6
29804830-0	2018	ZFAND1 Recruits p97 and the 26S Proteasome to Promote the Clearance of Arsenite-Induced Stress Granules.	arsenite	71-79	melanotransferrin	Homo sapiens	16-19
29804830-5	2018	ZFAND1 interacts with two key factors of protein degradation, the 26S proteasome and the ubiquitin-selective segregase p97, and recruits them to arsenite-induced SGs.	arsenite	145-153	zinc finger AN1-type containing 1	Homo sapiens	0-6
29804830-5	2018	ZFAND1 interacts with two key factors of protein degradation, the 26S proteasome and the ubiquitin-selective segregase p97, and recruits them to arsenite-induced SGs.	arsenite	145-153	melanotransferrin	Homo sapiens	119-122
29654755-2	2018	Recently, we have demonstrated that Ubc-/- (Ub-deficient) mouse embryonic fibroblasts (MEFs) exhibited reduced viability under oxidative stress induced by arsenite, which was not due to dysregulation of the antioxidant response pathway, but rather due to the potential toxicity caused by the misfolded protein aggregates.	arsenite	155-163	ubiquitin C	Mus musculus	36-39
29240254-0	2018	NF-kappaB-regulated miR-155, via repression of QKI, contributes to the acquisition of CSC-like phenotype during the neoplastic transformation of hepatic cells induced by arsenite.	arsenite	170-178	microRNA 155	Homo sapiens	20-27
29882401-7	2018	The results showed that the mutagenic effects of arsenite (10 muM) and silver nanoparticles (10 mug/mL) were 70 +- 3 and 99 +- 7 per 105 survivors, respectively.	arsenite	49-57	latexin	Homo sapiens	62-65
29658272-0	2018	Arsenite Targets the RING Finger Domain of Rbx1 E3 Ubiquitin Ligase to Inhibit Proteasome-Mediated Degradation of Nrf2.	arsenite	0-8	ring-box 1	Homo sapiens	43-47
29658272-0	2018	Arsenite Targets the RING Finger Domain of Rbx1 E3 Ubiquitin Ligase to Inhibit Proteasome-Mediated Degradation of Nrf2.	arsenite	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	114-118
29658272-2	2018	Arsenite, a widespread contaminant in drinking water, is known to induce oxidative stress and activate the Nrf2-dependent signaling pathway through the stabilization of the Nrf2 protein by inhibiting its ubiquitination via the Cul3-Rbx1-Keap1 (cullin 3, RING-box 1, and Kelch-like ECH-associated protein 1) E3 ubiquitin ligase, and its degradation by the 26S proteasome, though the underlying mechanism, remains elusive.	arsenite	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	107-111
29658272-2	2018	Arsenite, a widespread contaminant in drinking water, is known to induce oxidative stress and activate the Nrf2-dependent signaling pathway through the stabilization of the Nrf2 protein by inhibiting its ubiquitination via the Cul3-Rbx1-Keap1 (cullin 3, RING-box 1, and Kelch-like ECH-associated protein 1) E3 ubiquitin ligase, and its degradation by the 26S proteasome, though the underlying mechanism, remains elusive.	arsenite	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	173-177
29658272-2	2018	Arsenite, a widespread contaminant in drinking water, is known to induce oxidative stress and activate the Nrf2-dependent signaling pathway through the stabilization of the Nrf2 protein by inhibiting its ubiquitination via the Cul3-Rbx1-Keap1 (cullin 3, RING-box 1, and Kelch-like ECH-associated protein 1) E3 ubiquitin ligase, and its degradation by the 26S proteasome, though the underlying mechanism, remains elusive.	arsenite	0-8	cullin 3	Homo sapiens	227-231
29658272-2	2018	Arsenite, a widespread contaminant in drinking water, is known to induce oxidative stress and activate the Nrf2-dependent signaling pathway through the stabilization of the Nrf2 protein by inhibiting its ubiquitination via the Cul3-Rbx1-Keap1 (cullin 3, RING-box 1, and Kelch-like ECH-associated protein 1) E3 ubiquitin ligase, and its degradation by the 26S proteasome, though the underlying mechanism, remains elusive.	arsenite	0-8	ring-box 1	Homo sapiens	232-236
29658272-2	2018	Arsenite, a widespread contaminant in drinking water, is known to induce oxidative stress and activate the Nrf2-dependent signaling pathway through the stabilization of the Nrf2 protein by inhibiting its ubiquitination via the Cul3-Rbx1-Keap1 (cullin 3, RING-box 1, and Kelch-like ECH-associated protein 1) E3 ubiquitin ligase, and its degradation by the 26S proteasome, though the underlying mechanism, remains elusive.	arsenite	0-8	kelch like ECH associated protein 1	Homo sapiens	237-242
29658272-2	2018	Arsenite, a widespread contaminant in drinking water, is known to induce oxidative stress and activate the Nrf2-dependent signaling pathway through the stabilization of the Nrf2 protein by inhibiting its ubiquitination via the Cul3-Rbx1-Keap1 (cullin 3, RING-box 1, and Kelch-like ECH-associated protein 1) E3 ubiquitin ligase, and its degradation by the 26S proteasome, though the underlying mechanism, remains elusive.	arsenite	0-8	cullin 3	Homo sapiens	244-252
29658272-2	2018	Arsenite, a widespread contaminant in drinking water, is known to induce oxidative stress and activate the Nrf2-dependent signaling pathway through the stabilization of the Nrf2 protein by inhibiting its ubiquitination via the Cul3-Rbx1-Keap1 (cullin 3, RING-box 1, and Kelch-like ECH-associated protein 1) E3 ubiquitin ligase, and its degradation by the 26S proteasome, though the underlying mechanism, remains elusive.	arsenite	0-8	ring-box 1	Homo sapiens	254-264
29658272-2	2018	Arsenite, a widespread contaminant in drinking water, is known to induce oxidative stress and activate the Nrf2-dependent signaling pathway through the stabilization of the Nrf2 protein by inhibiting its ubiquitination via the Cul3-Rbx1-Keap1 (cullin 3, RING-box 1, and Kelch-like ECH-associated protein 1) E3 ubiquitin ligase, and its degradation by the 26S proteasome, though the underlying mechanism, remains elusive.	arsenite	0-8	kelch like ECH associated protein 1	Homo sapiens	270-305
29475162-3	2018	Arsenite (As(III)) and arsenate (As(V)) spanned 0-80% and 20-100% of total As (1.2-206 mug L-1), respectively.	arsenite	0-8	immunoglobulin kappa variable 1-16	Homo sapiens	91-94
29658272-3	2018	In the present study, we demonstrated that arsenite could bind to the RING finger domain of Rbx1 in vitro and in cells, which led to the suppression of Cul3-Rbx1 E3 ubiquitin ligase activity, thereby impairing the Nrf2 ubiquitination and activating the Nrf2-induced antioxidant signaling pathway.	arsenite	43-51	ring-box 1	Homo sapiens	92-96
29658272-3	2018	In the present study, we demonstrated that arsenite could bind to the RING finger domain of Rbx1 in vitro and in cells, which led to the suppression of Cul3-Rbx1 E3 ubiquitin ligase activity, thereby impairing the Nrf2 ubiquitination and activating the Nrf2-induced antioxidant signaling pathway.	arsenite	43-51	cullin 3	Homo sapiens	152-156
29658272-3	2018	In the present study, we demonstrated that arsenite could bind to the RING finger domain of Rbx1 in vitro and in cells, which led to the suppression of Cul3-Rbx1 E3 ubiquitin ligase activity, thereby impairing the Nrf2 ubiquitination and activating the Nrf2-induced antioxidant signaling pathway.	arsenite	43-51	ring-box 1	Homo sapiens	157-161
29658272-3	2018	In the present study, we demonstrated that arsenite could bind to the RING finger domain of Rbx1 in vitro and in cells, which led to the suppression of Cul3-Rbx1 E3 ubiquitin ligase activity, thereby impairing the Nrf2 ubiquitination and activating the Nrf2-induced antioxidant signaling pathway.	arsenite	43-51	NFE2 like bZIP transcription factor 2	Homo sapiens	214-218
29658272-3	2018	In the present study, we demonstrated that arsenite could bind to the RING finger domain of Rbx1 in vitro and in cells, which led to the suppression of Cul3-Rbx1 E3 ubiquitin ligase activity, thereby impairing the Nrf2 ubiquitination and activating the Nrf2-induced antioxidant signaling pathway.	arsenite	43-51	NFE2 like bZIP transcription factor 2	Homo sapiens	253-257
29658272-4	2018	Our finding provided novel insight into arsenic toxicity by uncovering a distinct mechanism accounting for arsenite-induced Nrf2 activation.	arsenite	107-115	NFE2 like bZIP transcription factor 2	Homo sapiens	124-128
29350772-0	2018	Arsenite-induced histone H3 modification and its effects on EGR1 and FOS expression in HeLa cells.	arsenite	0-8	early growth response 1	Homo sapiens	60-64
29350772-0	2018	Arsenite-induced histone H3 modification and its effects on EGR1 and FOS expression in HeLa cells.	arsenite	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	69-72
29526526-8	2018	We conclude that, in the arsenite toxicity paradigm under investigation, mitoO2- represents the only trigger of two opposite pathways leading to activation of the Nrf2 signaling and/or to a MPT-dependent apoptotic death.	arsenite	25-33	NFE2 like bZIP transcription factor 2	Homo sapiens	163-167
29148585-7	2018	Our findings indicated that arsenite decreased global H3K4me3 and H3K9me2 levels during cell transformation by modulating the enzymatic activities of histone methyltransferases and/or HDMs, and by upregulation of KDM5A protein levels for H3K4me3.	arsenite	28-36	lysine demethylase 5A	Homo sapiens	213-218
29240254-0	2018	NF-kappaB-regulated miR-155, via repression of QKI, contributes to the acquisition of CSC-like phenotype during the neoplastic transformation of hepatic cells induced by arsenite.	arsenite	170-178	QKI, KH domain containing RNA binding	Homo sapiens	47-50
29240254-5	2018	Here, we show that long-term exposure of L-02 cells to arsenite increases miR-155 levels by activation of NF-kappaB and leads to the acquisition of CSC-like properties.	arsenite	55-63	microRNA 155	Homo sapiens	74-81
29240254-6	2018	In spheroids formed from arsenite-transformed L-02 cells, the levels of miR-155 positively relate to the levels of CD90, EpCAM, and OCT4.	arsenite	25-33	microRNA 155	Homo sapiens	72-79
29240254-6	2018	In spheroids formed from arsenite-transformed L-02 cells, the levels of miR-155 positively relate to the levels of CD90, EpCAM, and OCT4.	arsenite	25-33	Thy-1 cell surface antigen	Homo sapiens	115-119
29240254-6	2018	In spheroids formed from arsenite-transformed L-02 cells, the levels of miR-155 positively relate to the levels of CD90, EpCAM, and OCT4.	arsenite	25-33	epithelial cell adhesion molecule	Homo sapiens	121-126
29240254-6	2018	In spheroids formed from arsenite-transformed L-02 cells, the levels of miR-155 positively relate to the levels of CD90, EpCAM, and OCT4.	arsenite	25-33	POU class 5 homeobox 1	Homo sapiens	132-136
29240254-9	2018	Inhibition of QKI expression by miR-155 promotes arsenite-induced acquisition of CSC-like properties, whereas QKI over-expression has the opposite effect.	arsenite	49-57	QKI, KH domain containing RNA binding	Homo sapiens	14-17
29240254-9	2018	Inhibition of QKI expression by miR-155 promotes arsenite-induced acquisition of CSC-like properties, whereas QKI over-expression has the opposite effect.	arsenite	49-57	microRNA 155	Homo sapiens	32-39
29240254-10	2018	Collectively, the findings demonstrate that miR-155, driven by NF-kappaB, reduces QKI expression and is involved in acquisition of the CSC-like phenotype during neoplastic transformation of hepatic cells induced by arsenite.	arsenite	215-223	microRNA 155	Homo sapiens	44-51
29240254-10	2018	Collectively, the findings demonstrate that miR-155, driven by NF-kappaB, reduces QKI expression and is involved in acquisition of the CSC-like phenotype during neoplastic transformation of hepatic cells induced by arsenite.	arsenite	215-223	QKI, KH domain containing RNA binding	Homo sapiens	82-85
29216394-0	2018	CircLRP6 Regulation of ZEB1 via miR-455 Is Involved in the Epithelial-Mesenchymal Transition During Arsenite-Induced Malignant Transformation of Human Keratinocytes.	arsenite	100-108	zinc finger E-box binding homeobox 1	Homo sapiens	23-27
29216394-0	2018	CircLRP6 Regulation of ZEB1 via miR-455 Is Involved in the Epithelial-Mesenchymal Transition During Arsenite-Induced Malignant Transformation of Human Keratinocytes.	arsenite	100-108	microRNA 455	Homo sapiens	32-39
29277653-0	2018	MicroRNA-191, regulated by HIF-2alpha, is involved in EMT and acquisition of a stem cell-like phenotype in arsenite-transformed human liver epithelial cells.	arsenite	107-115	endothelial PAS domain protein 1	Homo sapiens	27-37
29216394-5	2018	For these cells, chronic exposure to arsenite caused an increase of circLRP6 and the transcription factor ZEB1, which induced the EMT.	arsenite	37-45	zinc finger E-box binding homeobox 1	Homo sapiens	106-110
29277653-4	2018	Here, we show that acute or chronic exposure of human liver epithelial L-02 cells to arsenite increased expression of miR-191.	arsenite	85-93	microRNA 191	Homo sapiens	118-125
29216394-8	2018	These results suggest that, in HaCaT cells, arsenite increases circLRP6 levels, which act as a sponge for miR-455 and up-regulate the miR-455 target, ZEB1, which subsequently induces the EMT, thus promoting malignant transformation.	arsenite	44-52	microRNA 455	Homo sapiens	106-113
29277653-5	2018	There were decreased levels of BASP-1 and E-cadherin and increased levels of WT-1 and N-cadherin, indicating that arsenite induced epithelial-mesenchymal transition (EMT).	arsenite	114-122	brain abundant membrane attached signal protein 1	Homo sapiens	31-37
29216394-8	2018	These results suggest that, in HaCaT cells, arsenite increases circLRP6 levels, which act as a sponge for miR-455 and up-regulate the miR-455 target, ZEB1, which subsequently induces the EMT, thus promoting malignant transformation.	arsenite	44-52	microRNA 455	Homo sapiens	134-141
29277653-5	2018	There were decreased levels of BASP-1 and E-cadherin and increased levels of WT-1 and N-cadherin, indicating that arsenite induced epithelial-mesenchymal transition (EMT).	arsenite	114-122	cadherin 1	Homo sapiens	42-52
29216394-8	2018	These results suggest that, in HaCaT cells, arsenite increases circLRP6 levels, which act as a sponge for miR-455 and up-regulate the miR-455 target, ZEB1, which subsequently induces the EMT, thus promoting malignant transformation.	arsenite	44-52	zinc finger E-box binding homeobox 1	Homo sapiens	150-154
29277653-5	2018	There were decreased levels of BASP-1 and E-cadherin and increased levels of WT-1 and N-cadherin, indicating that arsenite induced epithelial-mesenchymal transition (EMT).	arsenite	114-122	WT1 transcription factor	Homo sapiens	77-81
29216394-9	2018	Thus, for HaCaT cells chronically exposed to arsenite, circLRP6 via miR-455 regulation of ZEB1 is involved in the EMT during malignant transformation.	arsenite	45-53	microRNA 455	Homo sapiens	68-75
29216394-9	2018	Thus, for HaCaT cells chronically exposed to arsenite, circLRP6 via miR-455 regulation of ZEB1 is involved in the EMT during malignant transformation.	arsenite	45-53	zinc finger E-box binding homeobox 1	Homo sapiens	90-94
29277653-5	2018	There were decreased levels of BASP-1 and E-cadherin and increased levels of WT-1 and N-cadherin, indicating that arsenite induced epithelial-mesenchymal transition (EMT).	arsenite	114-122	cadherin 2	Homo sapiens	86-96
29277653-6	2018	Moreover, arsenite increased EpCAM and CD90 mRNA levels, showing the acquisition of stem cell-like properties by these cells.	arsenite	10-18	epithelial cell adhesion molecule	Homo sapiens	29-34
29528074-8	2018	The results suggest that regulation of Cyclin D1 protein expression by arsenite in SV-HUC-1 cells is dependent on ERK/NFAT2 and ERK/NF-kappaB, but is not dependent on JNK or p38.	arsenite	71-79	cyclin D1	Homo sapiens	39-48
29277653-6	2018	Moreover, arsenite increased EpCAM and CD90 mRNA levels, showing the acquisition of stem cell-like properties by these cells.	arsenite	10-18	Thy-1 cell surface antigen	Homo sapiens	39-43
29277653-9	2018	Luciferase reporter assays indicated that miR-191 was a target of HIF-2alpha, and inhibition of miR-191 decreased the neoplastic and metastatic properties of arsenite-transformed L-02 cells.	arsenite	158-166	microRNA 191	Homo sapiens	42-49
29277653-9	2018	Luciferase reporter assays indicated that miR-191 was a target of HIF-2alpha, and inhibition of miR-191 decreased the neoplastic and metastatic properties of arsenite-transformed L-02 cells.	arsenite	158-166	endothelial PAS domain protein 1	Homo sapiens	66-76
29277653-9	2018	Luciferase reporter assays indicated that miR-191 was a target of HIF-2alpha, and inhibition of miR-191 decreased the neoplastic and metastatic properties of arsenite-transformed L-02 cells.	arsenite	158-166	microRNA 191	Homo sapiens	96-103
29277653-10	2018	Thus, in arsenite-transformed liver epithelial cells, transcriptional activation of the miR-191 promoter by HIF-2alpha is involved in EMT and in the acquisition of a stem cell-like phenotype.	arsenite	9-17	microRNA 191	Homo sapiens	88-95
29277653-10	2018	Thus, in arsenite-transformed liver epithelial cells, transcriptional activation of the miR-191 promoter by HIF-2alpha is involved in EMT and in the acquisition of a stem cell-like phenotype.	arsenite	9-17	endothelial PAS domain protein 1	Homo sapiens	108-118
29566083-8	2018	Stable expression of AQP9 in HEK cells increases their vulnerability to MPP+ and to arsenite-another parkinsonogenic toxin.	arsenite	84-92	aquaporin 9	Mus musculus	21-25
29528074-0	2018	Arsenite increases Cyclin D1 expression through coordinated regulation of the Ca2+/NFAT2 and NF-kappaB pathways via ERK/MAPK in a human uroepithelial cell line.	arsenite	0-8	cyclin D1	Homo sapiens	19-28
29528074-0	2018	Arsenite increases Cyclin D1 expression through coordinated regulation of the Ca2+/NFAT2 and NF-kappaB pathways via ERK/MAPK in a human uroepithelial cell line.	arsenite	0-8	nuclear factor of activated T cells 2	Homo sapiens	83-88
29528074-0	2018	Arsenite increases Cyclin D1 expression through coordinated regulation of the Ca2+/NFAT2 and NF-kappaB pathways via ERK/MAPK in a human uroepithelial cell line.	arsenite	0-8	nuclear factor kappa B subunit 1	Homo sapiens	93-102
29528074-0	2018	Arsenite increases Cyclin D1 expression through coordinated regulation of the Ca2+/NFAT2 and NF-kappaB pathways via ERK/MAPK in a human uroepithelial cell line.	arsenite	0-8	mitogen-activated protein kinase 1	Homo sapiens	116-119
29528074-3	2018	We found that arsenite increased the intracellular Ca2+ levels and induced NFAT2 nuclear translocation after treatment for 24 h. The level of NFAT2 mRNA and expression of total protein and nuclear protein were increased after long-term treatment with 0.5 muM arsenite for 30 and 40 weeks compared to the cells treated for 24 h. In addition, NF-kappaB p50 and p65 nuclear protein expression increased significantly in cells treated with 2-8 muM arsenite for 24 h, which was consistent with NFAT2 nuclear expression.	arsenite	14-22	nuclear factor of activated T cells 2	Homo sapiens	75-80
29528074-3	2018	We found that arsenite increased the intracellular Ca2+ levels and induced NFAT2 nuclear translocation after treatment for 24 h. The level of NFAT2 mRNA and expression of total protein and nuclear protein were increased after long-term treatment with 0.5 muM arsenite for 30 and 40 weeks compared to the cells treated for 24 h. In addition, NF-kappaB p50 and p65 nuclear protein expression increased significantly in cells treated with 2-8 muM arsenite for 24 h, which was consistent with NFAT2 nuclear expression.	arsenite	14-22	nuclear factor of activated T cells 2	Homo sapiens	142-147
29528074-3	2018	We found that arsenite increased the intracellular Ca2+ levels and induced NFAT2 nuclear translocation after treatment for 24 h. The level of NFAT2 mRNA and expression of total protein and nuclear protein were increased after long-term treatment with 0.5 muM arsenite for 30 and 40 weeks compared to the cells treated for 24 h. In addition, NF-kappaB p50 and p65 nuclear protein expression increased significantly in cells treated with 2-8 muM arsenite for 24 h, which was consistent with NFAT2 nuclear expression.	arsenite	14-22	nuclear factor kappa B subunit 1	Homo sapiens	341-354
29528074-3	2018	We found that arsenite increased the intracellular Ca2+ levels and induced NFAT2 nuclear translocation after treatment for 24 h. The level of NFAT2 mRNA and expression of total protein and nuclear protein were increased after long-term treatment with 0.5 muM arsenite for 30 and 40 weeks compared to the cells treated for 24 h. In addition, NF-kappaB p50 and p65 nuclear protein expression increased significantly in cells treated with 2-8 muM arsenite for 24 h, which was consistent with NFAT2 nuclear expression.	arsenite	14-22	RELA proto-oncogene, NF-kB subunit	Homo sapiens	359-362
29528074-3	2018	We found that arsenite increased the intracellular Ca2+ levels and induced NFAT2 nuclear translocation after treatment for 24 h. The level of NFAT2 mRNA and expression of total protein and nuclear protein were increased after long-term treatment with 0.5 muM arsenite for 30 and 40 weeks compared to the cells treated for 24 h. In addition, NF-kappaB p50 and p65 nuclear protein expression increased significantly in cells treated with 2-8 muM arsenite for 24 h, which was consistent with NFAT2 nuclear expression.	arsenite	14-22	nuclear factor of activated T cells 2	Homo sapiens	142-147
29528074-3	2018	We found that arsenite increased the intracellular Ca2+ levels and induced NFAT2 nuclear translocation after treatment for 24 h. The level of NFAT2 mRNA and expression of total protein and nuclear protein were increased after long-term treatment with 0.5 muM arsenite for 30 and 40 weeks compared to the cells treated for 24 h. In addition, NF-kappaB p50 and p65 nuclear protein expression increased significantly in cells treated with 2-8 muM arsenite for 24 h, which was consistent with NFAT2 nuclear expression.	arsenite	259-267	nuclear factor of activated T cells 2	Homo sapiens	142-147
29528074-3	2018	We found that arsenite increased the intracellular Ca2+ levels and induced NFAT2 nuclear translocation after treatment for 24 h. The level of NFAT2 mRNA and expression of total protein and nuclear protein were increased after long-term treatment with 0.5 muM arsenite for 30 and 40 weeks compared to the cells treated for 24 h. In addition, NF-kappaB p50 and p65 nuclear protein expression increased significantly in cells treated with 2-8 muM arsenite for 24 h, which was consistent with NFAT2 nuclear expression.	arsenite	259-267	nuclear factor of activated T cells 2	Homo sapiens	142-147
29528074-3	2018	We found that arsenite increased the intracellular Ca2+ levels and induced NFAT2 nuclear translocation after treatment for 24 h. The level of NFAT2 mRNA and expression of total protein and nuclear protein were increased after long-term treatment with 0.5 muM arsenite for 30 and 40 weeks compared to the cells treated for 24 h. In addition, NF-kappaB p50 and p65 nuclear protein expression increased significantly in cells treated with 2-8 muM arsenite for 24 h, which was consistent with NFAT2 nuclear expression.	arsenite	259-267	nuclear factor of activated T cells 2	Homo sapiens	142-147
29528074-3	2018	We found that arsenite increased the intracellular Ca2+ levels and induced NFAT2 nuclear translocation after treatment for 24 h. The level of NFAT2 mRNA and expression of total protein and nuclear protein were increased after long-term treatment with 0.5 muM arsenite for 30 and 40 weeks compared to the cells treated for 24 h. In addition, NF-kappaB p50 and p65 nuclear protein expression increased significantly in cells treated with 2-8 muM arsenite for 24 h, which was consistent with NFAT2 nuclear expression.	arsenite	259-267	nuclear factor of activated T cells 2	Homo sapiens	142-147
29528074-5	2018	Cyclin D1 is known as a proto-oncogene and the level of this protein was increased in SV-HUC-1 cells treated with arsenite for 24 h and long-term.	arsenite	114-122	cyclin D1	Homo sapiens	0-9
29281059-0	2018	Identification of C-terminal Regions in Arabidopsis thaliana Phytochelatin Synthase 1 Specifically Involved in Activation by Arsenite.	arsenite	125-133	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	61-85
29281059-4	2018	Here we identified C-terminal parts involved in arsenite- [As(III)] dependent activation of AtPCS1, the primary Arabidopsis PC synthase.	arsenite	48-56	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	92-98
29487587-8	2018	Both arsenite and pateamine A could efficiently induce the formation of stress granules containing TIA1 and eIF4G, whereas eIF3 and eIF2 failed to localize to these cytoplasmic bodies.	arsenite	5-13	TIA1 cytotoxic granule associated RNA binding protein	Homo sapiens	99-103
29487587-8	2018	Both arsenite and pateamine A could efficiently induce the formation of stress granules containing TIA1 and eIF4G, whereas eIF3 and eIF2 failed to localize to these cytoplasmic bodies.	arsenite	5-13	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	108-113
28956099-0	2018	Arsenite and methylarsonite inhibit mitochondrial metabolism and glucose-stimulated insulin secretion in INS-1 832/13 beta cells.	arsenite	0-8	insulin 1	Rattus norvegicus	105-110
28984870-4	2018	Arsenite (Ars)-induced oxidative stress increased cellular GADD34 levels and enhanced Sirtuin 1 (SIRT1) recruitment to assemble a cytoplasmic complex containing GADD34, PP1alpha, eIF2alpha and SIRT1.	arsenite	0-8	protein phosphatase 1 regulatory subunit 15A	Homo sapiens	59-65
28984870-4	2018	Arsenite (Ars)-induced oxidative stress increased cellular GADD34 levels and enhanced Sirtuin 1 (SIRT1) recruitment to assemble a cytoplasmic complex containing GADD34, PP1alpha, eIF2alpha and SIRT1.	arsenite	0-8	sirtuin 1	Homo sapiens	86-95
28984870-4	2018	Arsenite (Ars)-induced oxidative stress increased cellular GADD34 levels and enhanced Sirtuin 1 (SIRT1) recruitment to assemble a cytoplasmic complex containing GADD34, PP1alpha, eIF2alpha and SIRT1.	arsenite	0-8	sirtuin 1	Homo sapiens	97-102
28984870-4	2018	Arsenite (Ars)-induced oxidative stress increased cellular GADD34 levels and enhanced Sirtuin 1 (SIRT1) recruitment to assemble a cytoplasmic complex containing GADD34, PP1alpha, eIF2alpha and SIRT1.	arsenite	0-8	protein phosphatase 1 regulatory subunit 15A	Homo sapiens	161-167
28984870-4	2018	Arsenite (Ars)-induced oxidative stress increased cellular GADD34 levels and enhanced Sirtuin 1 (SIRT1) recruitment to assemble a cytoplasmic complex containing GADD34, PP1alpha, eIF2alpha and SIRT1.	arsenite	0-8	protein phosphatase 1 catalytic subunit alpha	Homo sapiens	169-177
28984870-4	2018	Arsenite (Ars)-induced oxidative stress increased cellular GADD34 levels and enhanced Sirtuin 1 (SIRT1) recruitment to assemble a cytoplasmic complex containing GADD34, PP1alpha, eIF2alpha and SIRT1.	arsenite	0-8	eukaryotic translation initiation factor 2A	Homo sapiens	179-188
28984870-4	2018	Arsenite (Ars)-induced oxidative stress increased cellular GADD34 levels and enhanced Sirtuin 1 (SIRT1) recruitment to assemble a cytoplasmic complex containing GADD34, PP1alpha, eIF2alpha and SIRT1.	arsenite	0-8	sirtuin 1	Homo sapiens	193-198
28984870-4	2018	Arsenite (Ars)-induced oxidative stress increased cellular GADD34 levels and enhanced Sirtuin 1 (SIRT1) recruitment to assemble a cytoplasmic complex containing GADD34, PP1alpha, eIF2alpha and SIRT1.	arsenite	0-3	protein phosphatase 1 regulatory subunit 15A	Homo sapiens	59-65
28984870-4	2018	Arsenite (Ars)-induced oxidative stress increased cellular GADD34 levels and enhanced Sirtuin 1 (SIRT1) recruitment to assemble a cytoplasmic complex containing GADD34, PP1alpha, eIF2alpha and SIRT1.	arsenite	0-3	sirtuin 1	Homo sapiens	86-95
28984870-4	2018	Arsenite (Ars)-induced oxidative stress increased cellular GADD34 levels and enhanced Sirtuin 1 (SIRT1) recruitment to assemble a cytoplasmic complex containing GADD34, PP1alpha, eIF2alpha and SIRT1.	arsenite	0-3	sirtuin 1	Homo sapiens	97-102
28984870-4	2018	Arsenite (Ars)-induced oxidative stress increased cellular GADD34 levels and enhanced Sirtuin 1 (SIRT1) recruitment to assemble a cytoplasmic complex containing GADD34, PP1alpha, eIF2alpha and SIRT1.	arsenite	0-3	protein phosphatase 1 regulatory subunit 15A	Homo sapiens	161-167
28984870-4	2018	Arsenite (Ars)-induced oxidative stress increased cellular GADD34 levels and enhanced Sirtuin 1 (SIRT1) recruitment to assemble a cytoplasmic complex containing GADD34, PP1alpha, eIF2alpha and SIRT1.	arsenite	0-3	protein phosphatase 1 catalytic subunit alpha	Homo sapiens	169-177
28984870-4	2018	Arsenite (Ars)-induced oxidative stress increased cellular GADD34 levels and enhanced Sirtuin 1 (SIRT1) recruitment to assemble a cytoplasmic complex containing GADD34, PP1alpha, eIF2alpha and SIRT1.	arsenite	0-3	eukaryotic translation initiation factor 2A	Homo sapiens	179-188
28984870-4	2018	Arsenite (Ars)-induced oxidative stress increased cellular GADD34 levels and enhanced Sirtuin 1 (SIRT1) recruitment to assemble a cytoplasmic complex containing GADD34, PP1alpha, eIF2alpha and SIRT1.	arsenite	0-3	sirtuin 1	Homo sapiens	193-198
29398653-7	2018	Genotyping for the main arsenite and selenium methyltransferases, AS3MT and INMT, was performed using TaqMan probes or Sequenom.	arsenite	24-32	arsenite methyltransferase	Homo sapiens	66-71
29031483-7	2018	A survey in the keratinocytes of metal/metalloid compounds showed that arsenite, antimonite, chromate, cadmium, copper, lead and vanadate suppressed DUOX1 levels but did not prevent interleukin 4 stimulation.	arsenite	71-79	dual oxidase 1	Homo sapiens	149-154
29528074-8	2018	The results suggest that regulation of Cyclin D1 protein expression by arsenite in SV-HUC-1 cells is dependent on ERK/NFAT2 and ERK/NF-kappaB, but is not dependent on JNK or p38.	arsenite	71-79	mitogen-activated protein kinase 1	Homo sapiens	114-117
29528074-8	2018	The results suggest that regulation of Cyclin D1 protein expression by arsenite in SV-HUC-1 cells is dependent on ERK/NFAT2 and ERK/NF-kappaB, but is not dependent on JNK or p38.	arsenite	71-79	nuclear factor of activated T cells 2	Homo sapiens	118-123
29528074-8	2018	The results suggest that regulation of Cyclin D1 protein expression by arsenite in SV-HUC-1 cells is dependent on ERK/NFAT2 and ERK/NF-kappaB, but is not dependent on JNK or p38.	arsenite	71-79	mitogen-activated protein kinase 1	Homo sapiens	128-131
29528074-8	2018	The results suggest that regulation of Cyclin D1 protein expression by arsenite in SV-HUC-1 cells is dependent on ERK/NFAT2 and ERK/NF-kappaB, but is not dependent on JNK or p38.	arsenite	71-79	nuclear factor kappa B subunit 1	Homo sapiens	132-141
29080535-5	2018	An arsH gene encoding an organoarsenical oxidase protein was observed in arsenite-oxidizing Citrobacter freundii strain VTan4 (DQ481466), whereas arsB, arsH, and arsH were detected in Pseudomonas putida strain VTw33 (DQ481482).	arsenite	73-81	ArsH	Citrobacter freundii	3-7
29217265-5	2018	The methylation of arsenite by arsenite-3-methyltransferase (As3MT) promotes the clearance of arsenic as pentavalent species, but also generates reactive trivalent intermediates.	arsenite	19-27	arsenite methyltransferase	Homo sapiens	31-59
29217265-5	2018	The methylation of arsenite by arsenite-3-methyltransferase (As3MT) promotes the clearance of arsenic as pentavalent species, but also generates reactive trivalent intermediates.	arsenite	19-27	arsenite methyltransferase	Homo sapiens	61-66
28973481-0	2017	Arsenite Induces Vascular Endothelial Cell Dysfunction by Activating IRE1alpha/XBP1s/HIF1alpha-Dependent ANGII Signaling.	arsenite	0-8	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	69-78
29479036-0	2018	Arsenite exposure potentiates apoptosis-inducing effects of tumor necrosis factor-alpha- through reactive oxygen species.	arsenite	0-8	tumor necrosis factor	Homo sapiens	60-87
29233969-4	2017	When neurons are stressed such as by heat shock or sodium arsenite (As), cells engage specific proteosome-mediated degradation to reduce RIP140 level, thereby relieving the suppression and activating HSR.	arsenite	68-70	nuclear receptor interacting protein 1	Mus musculus	137-143
29233969-7	2017	Reducing hippocampal RIP140 in the mouse rescues chronic As-induced spatial learning deficits.	arsenite	57-59	nuclear receptor interacting protein 1	Mus musculus	21-27
28861715-1	2017	Activating transcription factor-5 (ATF5) is a stress-response transcription factor induced upon different cell stressors like fasting, amino-acid limitation, cadmium or arsenite.	arsenite	169-177	activating transcription factor 5	Homo sapiens	0-33
28861715-1	2017	Activating transcription factor-5 (ATF5) is a stress-response transcription factor induced upon different cell stressors like fasting, amino-acid limitation, cadmium or arsenite.	arsenite	169-177	activating transcription factor 5	Homo sapiens	35-39
28973481-0	2017	Arsenite Induces Vascular Endothelial Cell Dysfunction by Activating IRE1alpha/XBP1s/HIF1alpha-Dependent ANGII Signaling.	arsenite	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	85-94
28973481-0	2017	Arsenite Induces Vascular Endothelial Cell Dysfunction by Activating IRE1alpha/XBP1s/HIF1alpha-Dependent ANGII Signaling.	arsenite	0-8	angiotensinogen	Homo sapiens	105-110
28973481-4	2017	Here, we reported that exposure of human umbilical vein endothelial cells (HUVECs) to arsenite resulted in elevation of angiotensinogen (AGT, the precursor of ANGII), angiotensin-converting enzyme (ACE, the enzyme critical for ANGII generation), and ANGII type I receptor (AT1R) synthesis as well as increased ANGII production.	arsenite	86-94	angiotensinogen	Homo sapiens	120-135
28973481-4	2017	Here, we reported that exposure of human umbilical vein endothelial cells (HUVECs) to arsenite resulted in elevation of angiotensinogen (AGT, the precursor of ANGII), angiotensin-converting enzyme (ACE, the enzyme critical for ANGII generation), and ANGII type I receptor (AT1R) synthesis as well as increased ANGII production.	arsenite	86-94	angiotensinogen	Homo sapiens	137-140
28973481-4	2017	Here, we reported that exposure of human umbilical vein endothelial cells (HUVECs) to arsenite resulted in elevation of angiotensinogen (AGT, the precursor of ANGII), angiotensin-converting enzyme (ACE, the enzyme critical for ANGII generation), and ANGII type I receptor (AT1R) synthesis as well as increased ANGII production.	arsenite	86-94	angiotensinogen	Homo sapiens	159-164
28973481-4	2017	Here, we reported that exposure of human umbilical vein endothelial cells (HUVECs) to arsenite resulted in elevation of angiotensinogen (AGT, the precursor of ANGII), angiotensin-converting enzyme (ACE, the enzyme critical for ANGII generation), and ANGII type I receptor (AT1R) synthesis as well as increased ANGII production.	arsenite	86-94	angiotensin I converting enzyme	Homo sapiens	167-196
28973481-4	2017	Here, we reported that exposure of human umbilical vein endothelial cells (HUVECs) to arsenite resulted in elevation of angiotensinogen (AGT, the precursor of ANGII), angiotensin-converting enzyme (ACE, the enzyme critical for ANGII generation), and ANGII type I receptor (AT1R) synthesis as well as increased ANGII production.	arsenite	86-94	angiotensin I converting enzyme	Homo sapiens	198-201
28973481-4	2017	Here, we reported that exposure of human umbilical vein endothelial cells (HUVECs) to arsenite resulted in elevation of angiotensinogen (AGT, the precursor of ANGII), angiotensin-converting enzyme (ACE, the enzyme critical for ANGII generation), and ANGII type I receptor (AT1R) synthesis as well as increased ANGII production.	arsenite	86-94	angiotensinogen	Homo sapiens	227-232
28973481-4	2017	Here, we reported that exposure of human umbilical vein endothelial cells (HUVECs) to arsenite resulted in elevation of angiotensinogen (AGT, the precursor of ANGII), angiotensin-converting enzyme (ACE, the enzyme critical for ANGII generation), and ANGII type I receptor (AT1R) synthesis as well as increased ANGII production.	arsenite	86-94	angiotensinogen	Homo sapiens	227-232
28973481-4	2017	Here, we reported that exposure of human umbilical vein endothelial cells (HUVECs) to arsenite resulted in elevation of angiotensinogen (AGT, the precursor of ANGII), angiotensin-converting enzyme (ACE, the enzyme critical for ANGII generation), and ANGII type I receptor (AT1R) synthesis as well as increased ANGII production.	arsenite	86-94	angiotensin II receptor type 1	Homo sapiens	273-277
28973481-4	2017	Here, we reported that exposure of human umbilical vein endothelial cells (HUVECs) to arsenite resulted in elevation of angiotensinogen (AGT, the precursor of ANGII), angiotensin-converting enzyme (ACE, the enzyme critical for ANGII generation), and ANGII type I receptor (AT1R) synthesis as well as increased ANGII production.	arsenite	86-94	angiotensinogen	Homo sapiens	227-232
28973481-5	2017	Further investigations showed that endoplasmic reticulum (ER) stress was induced and activation of the IRE1alpha/XBP1s arm of the unfolded protein response was responsible for the augmented ACE/ANGII/AT1R axis components in arsenite-treated HUVECs.	arsenite	224-232	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	103-112
28973481-5	2017	Further investigations showed that endoplasmic reticulum (ER) stress was induced and activation of the IRE1alpha/XBP1s arm of the unfolded protein response was responsible for the augmented ACE/ANGII/AT1R axis components in arsenite-treated HUVECs.	arsenite	224-232	X-box binding protein 1	Homo sapiens	113-117
28973481-5	2017	Further investigations showed that endoplasmic reticulum (ER) stress was induced and activation of the IRE1alpha/XBP1s arm of the unfolded protein response was responsible for the augmented ACE/ANGII/AT1R axis components in arsenite-treated HUVECs.	arsenite	224-232	angiotensin I converting enzyme	Homo sapiens	190-193
28973481-5	2017	Further investigations showed that endoplasmic reticulum (ER) stress was induced and activation of the IRE1alpha/XBP1s arm of the unfolded protein response was responsible for the augmented ACE/ANGII/AT1R axis components in arsenite-treated HUVECs.	arsenite	224-232	angiotensinogen	Homo sapiens	194-199
28973481-5	2017	Further investigations showed that endoplasmic reticulum (ER) stress was induced and activation of the IRE1alpha/XBP1s arm of the unfolded protein response was responsible for the augmented ACE/ANGII/AT1R axis components in arsenite-treated HUVECs.	arsenite	224-232	angiotensin II receptor type 1	Homo sapiens	200-204
28973481-6	2017	Moreover, XBP1s promoted HIF1alpha accumulation, and inducible XBP1s/HIF1alpha complex formation was required to drive the transcription of AGT, ACE, and AT1R under arsenite exposure.	arsenite	165-173	X-box binding protein 1	Homo sapiens	10-14
28973481-6	2017	Moreover, XBP1s promoted HIF1alpha accumulation, and inducible XBP1s/HIF1alpha complex formation was required to drive the transcription of AGT, ACE, and AT1R under arsenite exposure.	arsenite	165-173	X-box binding protein 1	Homo sapiens	63-67
28973481-6	2017	Moreover, XBP1s promoted HIF1alpha accumulation, and inducible XBP1s/HIF1alpha complex formation was required to drive the transcription of AGT, ACE, and AT1R under arsenite exposure.	arsenite	165-173	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-78
28973481-6	2017	Moreover, XBP1s promoted HIF1alpha accumulation, and inducible XBP1s/HIF1alpha complex formation was required to drive the transcription of AGT, ACE, and AT1R under arsenite exposure.	arsenite	165-173	angiotensinogen	Homo sapiens	140-143
28973481-6	2017	Moreover, XBP1s promoted HIF1alpha accumulation, and inducible XBP1s/HIF1alpha complex formation was required to drive the transcription of AGT, ACE, and AT1R under arsenite exposure.	arsenite	165-173	angiotensin I converting enzyme	Homo sapiens	145-148
28973481-6	2017	Moreover, XBP1s promoted HIF1alpha accumulation, and inducible XBP1s/HIF1alpha complex formation was required to drive the transcription of AGT, ACE, and AT1R under arsenite exposure.	arsenite	165-173	angiotensin II receptor type 1	Homo sapiens	154-158
28973481-7	2017	Ablation of IRE1alpha/XBP1s/HIF1alpha-dependent ANGII signaling activation inhibited oxidative stress and proinflammatory response induced in HUVECs by arsenite.	arsenite	152-160	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	12-21
28973481-7	2017	Ablation of IRE1alpha/XBP1s/HIF1alpha-dependent ANGII signaling activation inhibited oxidative stress and proinflammatory response induced in HUVECs by arsenite.	arsenite	152-160	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-37
28973481-7	2017	Ablation of IRE1alpha/XBP1s/HIF1alpha-dependent ANGII signaling activation inhibited oxidative stress and proinflammatory response induced in HUVECs by arsenite.	arsenite	152-160	angiotensinogen	Homo sapiens	48-53
28973481-8	2017	These results thus have revealed the novel role of ER stress-coupled HIF1alpha pathway activation in mediating ANGII-dependent endothelial cell dysfunction upon arsenite exposure.	arsenite	161-169	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-78
28973481-8	2017	These results thus have revealed the novel role of ER stress-coupled HIF1alpha pathway activation in mediating ANGII-dependent endothelial cell dysfunction upon arsenite exposure.	arsenite	161-169	angiotensinogen	Homo sapiens	111-116
28973481-9	2017	Therefore, searching for strategies to alleviate endothelial ER stress or ANGII signaling might be helpful for managing arsenite-induced CV disorders.	arsenite	120-128	angiotensinogen	Homo sapiens	74-79
28901367-11	2017	Moreover, protein expression of both PSD-95 and SYP decreased significantly in arsenite exposure groups.	arsenite	79-87	discs large MAGUK scaffold protein 4	Mus musculus	37-43
28888487-6	2017	Therefore, in arsenite-induced transformation of L-02 cells, the accumulation of p62, by impairing autophagic flux, mediates the EMT via Snail.	arsenite	14-22	snail family transcriptional repressor 1	Homo sapiens	137-142
29084250-5	2017	KSHV ORF37 (vSOX) bearing intrinsic endoribonuclease activity also inhibits arsenite-induced SG formation, but KSHV RTA, vIRF-2, ORF45, ORF59 and LANA exert no such function.	arsenite	76-84	ORF37	Human gammaherpesvirus 8	5-10
28901367-11	2017	Moreover, protein expression of both PSD-95 and SYP decreased significantly in arsenite exposure groups.	arsenite	79-87	synaptophysin	Mus musculus	48-51
28798983-9	2017	AQP9 transport of MSeA, selenite and lactate is all inhibited by a previously identified AQP9 inhibitor, phloretin, and the AQP9 substrate arsenite (AsIII).	arsenite	139-147	aquaporin 9	Homo sapiens	0-4
28583009-0	2017	Inhibition of alpha-Synuclein contributes to the ameliorative effects of dietary flavonoids luteolin on arsenite-induced apoptotic cell death in the dopaminergic PC12 cells.	arsenite	104-112	synuclein alpha	Rattus norvegicus	14-29
28888487-0	2017	Impaired autophagic flux and p62-mediated EMT are involved in arsenite-induced transformation of L-02 cells.	arsenite	62-70	nucleoporin 62	Homo sapiens	29-32
28888487-2	2017	In arsenite-treated human hepatic epithelial (L-02) cells, arsenite reduced the autophagic flux, which caused accumulation of p62, an adaptor and receptor of autophagy.	arsenite	3-11	nucleoporin 62	Homo sapiens	126-129
28888487-2	2017	In arsenite-treated human hepatic epithelial (L-02) cells, arsenite reduced the autophagic flux, which caused accumulation of p62, an adaptor and receptor of autophagy.	arsenite	59-67	nucleoporin 62	Homo sapiens	126-129
28888487-3	2017	Further, in arsenite-transformed L-02 cells, the levels of E-cadherin were attenuated, but the levels of vimentin, which is expressed in mesenchymal cells, and Snail, a transcription regulator of the EMT, were up-regulated.	arsenite	12-20	cadherin 1	Homo sapiens	59-69
28888487-3	2017	Further, in arsenite-transformed L-02 cells, the levels of E-cadherin were attenuated, but the levels of vimentin, which is expressed in mesenchymal cells, and Snail, a transcription regulator of the EMT, were up-regulated.	arsenite	12-20	vimentin	Homo sapiens	105-113
28888487-3	2017	Further, in arsenite-transformed L-02 cells, the levels of E-cadherin were attenuated, but the levels of vimentin, which is expressed in mesenchymal cells, and Snail, a transcription regulator of the EMT, were up-regulated.	arsenite	12-20	snail family transcriptional repressor 1	Homo sapiens	160-165
28888487-4	2017	Thus, after chronic exposure of L-02 cells to arsenite, the impaired autophagic flux induced the accumulation of p62, which up-regulated the expression of Snail, a protein involved in arsenite-induced EMT of these cells.	arsenite	46-54	nucleoporin 62	Homo sapiens	113-116
28888487-4	2017	Thus, after chronic exposure of L-02 cells to arsenite, the impaired autophagic flux induced the accumulation of p62, which up-regulated the expression of Snail, a protein involved in arsenite-induced EMT of these cells.	arsenite	46-54	snail family transcriptional repressor 1	Homo sapiens	155-160
28888487-4	2017	Thus, after chronic exposure of L-02 cells to arsenite, the impaired autophagic flux induced the accumulation of p62, which up-regulated the expression of Snail, a protein involved in arsenite-induced EMT of these cells.	arsenite	184-192	nucleoporin 62	Homo sapiens	113-116
28888487-4	2017	Thus, after chronic exposure of L-02 cells to arsenite, the impaired autophagic flux induced the accumulation of p62, which up-regulated the expression of Snail, a protein involved in arsenite-induced EMT of these cells.	arsenite	184-192	snail family transcriptional repressor 1	Homo sapiens	155-160
28888487-5	2017	Knockdown of p62 by siRNA reversed the arsenite-induced EMT and decreased the capacities of arsenite-transformed L-02 cells for colony formation and invasion and migration.	arsenite	39-47	nucleoporin 62	Homo sapiens	13-16
28888487-5	2017	Knockdown of p62 by siRNA reversed the arsenite-induced EMT and decreased the capacities of arsenite-transformed L-02 cells for colony formation and invasion and migration.	arsenite	92-100	nucleoporin 62	Homo sapiens	13-16
28888487-6	2017	Therefore, in arsenite-induced transformation of L-02 cells, the accumulation of p62, by impairing autophagic flux, mediates the EMT via Snail.	arsenite	14-22	nucleoporin 62	Homo sapiens	81-84
28583009-5	2017	Our results further showed the expression of alpha-Synuclein (alpha-Syn) was significantly increased in arsenite-treated cells, but co-treatment with luteolin reversed the expression of alpha-Syn back toward normal level.	arsenite	104-112	synuclein alpha	Rattus norvegicus	45-60
28583009-5	2017	Our results further showed the expression of alpha-Synuclein (alpha-Syn) was significantly increased in arsenite-treated cells, but co-treatment with luteolin reversed the expression of alpha-Syn back toward normal level.	arsenite	104-112	synuclein alpha	Rattus norvegicus	45-54
28583009-5	2017	Our results further showed the expression of alpha-Synuclein (alpha-Syn) was significantly increased in arsenite-treated cells, but co-treatment with luteolin reversed the expression of alpha-Syn back toward normal level.	arsenite	104-112	synuclein alpha	Rattus norvegicus	62-71
28583009-6	2017	Inhibition of alpha-Syn by siRNA remarkably enhanced the beneficial effect of luteolin against arsenite-induced apoptotic cell death.	arsenite	95-103	synuclein alpha	Rattus norvegicus	14-23
28552776-0	2017	Differential sensitivities of cellular XPA and PARP-1 to arsenite inhibition and zinc rescue.	arsenite	57-65	XPA, DNA damage recognition and repair factor	Homo sapiens	39-42
28837777-0	2017	Arsenite Binds to the Zinc Finger Motif of TIP60 Histone Acetyltransferase and Induces Its Degradation via the 26S Proteasome.	arsenite	0-8	lysine acetyltransferase 5	Homo sapiens	43-48
28837777-4	2017	Arsenite is known to interact with zinc finger motifs of proteins, and zinc finger motif is present in and indispensable for the enzymatic activities of crucial histone-modifying enzymes especially the MYST family of histone acetyltransferases (e.g., TIP60).	arsenite	0-8	lysine acetyltransferase 5	Homo sapiens	202-206
28837777-4	2017	Arsenite is known to interact with zinc finger motifs of proteins, and zinc finger motif is present in and indispensable for the enzymatic activities of crucial histone-modifying enzymes especially the MYST family of histone acetyltransferases (e.g., TIP60).	arsenite	0-8	lysine acetyltransferase 5	Homo sapiens	251-256
28837777-8	2017	Thus, the results from the present study revealed, for the first time, that arsenite may target cysteine residues in the zinc-finger motif of the TIP60 histone acetyltransferase, thereby altering the H4K16Ac histone epigenetic mark.	arsenite	76-84	lysine acetyltransferase 5	Homo sapiens	146-151
28501331-0	2017	The expression of keratin 6 is regulated by the activation of the ERK1/2 pathway in arsenite transformed human urothelial cells.	arsenite	84-92	keratin 72	Homo sapiens	18-27
28501331-0	2017	The expression of keratin 6 is regulated by the activation of the ERK1/2 pathway in arsenite transformed human urothelial cells.	arsenite	84-92	mitogen-activated protein kinase 3	Homo sapiens	66-72
28501331-1	2017	Urothelial cancers have an environmental etiological component, and previous studies from our laboratory have shown that arsenite (As+3) can cause the malignant transformation of the immortalized urothelial cells (UROtsa), leading to the expression of keratin 6 (KRT6).	arsenite	121-129	keratin 72	Homo sapiens	252-261
28501331-1	2017	Urothelial cancers have an environmental etiological component, and previous studies from our laboratory have shown that arsenite (As+3) can cause the malignant transformation of the immortalized urothelial cells (UROtsa), leading to the expression of keratin 6 (KRT6).	arsenite	121-129	keratin 72	Homo sapiens	263-267
28552776-0	2017	Differential sensitivities of cellular XPA and PARP-1 to arsenite inhibition and zinc rescue.	arsenite	57-65	poly(ADP-ribose) polymerase 1	Homo sapiens	47-53
28552776-1	2017	Arsenite directly binds to the zinc finger domains of the DNA repair protein poly (ADP ribose) polymerase (PARP)-1, and inhibits PARP-1 activity in the base excision repair (BER) pathway.	arsenite	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	107-111
28552776-1	2017	Arsenite directly binds to the zinc finger domains of the DNA repair protein poly (ADP ribose) polymerase (PARP)-1, and inhibits PARP-1 activity in the base excision repair (BER) pathway.	arsenite	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	129-135
28552776-2	2017	PARP inhibition by arsenite enhances ultraviolet radiation (UVR)-induced DNA damage in keratinocytes, and the increase in DNA damage is reduced by zinc supplementation.	arsenite	19-27	poly(ADP-ribose) polymerase 1	Homo sapiens	0-4
28552776-3	2017	However, little is known about the effects of arsenite and zinc on the zinc finger nucleotide excision repair (NER) protein xeroderma pigmentosum group A (XPA).	arsenite	46-54	XPA, DNA damage recognition and repair factor	Homo sapiens	124-153
28552776-3	2017	However, little is known about the effects of arsenite and zinc on the zinc finger nucleotide excision repair (NER) protein xeroderma pigmentosum group A (XPA).	arsenite	46-54	XPA, DNA damage recognition and repair factor	Homo sapiens	155-158
28552776-5	2017	Arsenite targeted both XPA and PARP-1 in human keratinocytes, resulting in zinc loss from each protein and a pronounced decrease in XPA and PARP-1 binding to chromatin as demonstrated by Chip-on-Western assays.	arsenite	0-8	XPA, DNA damage recognition and repair factor	Homo sapiens	23-26
28552776-5	2017	Arsenite targeted both XPA and PARP-1 in human keratinocytes, resulting in zinc loss from each protein and a pronounced decrease in XPA and PARP-1 binding to chromatin as demonstrated by Chip-on-Western assays.	arsenite	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	31-37
28552776-5	2017	Arsenite targeted both XPA and PARP-1 in human keratinocytes, resulting in zinc loss from each protein and a pronounced decrease in XPA and PARP-1 binding to chromatin as demonstrated by Chip-on-Western assays.	arsenite	0-8	XPA, DNA damage recognition and repair factor	Homo sapiens	132-135
28552776-5	2017	Arsenite targeted both XPA and PARP-1 in human keratinocytes, resulting in zinc loss from each protein and a pronounced decrease in XPA and PARP-1 binding to chromatin as demonstrated by Chip-on-Western assays.	arsenite	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	140-146
28552776-6	2017	Zinc effectively restored DNA binding of PARP-1 and XPA to chromatin when zinc concentrations were equal to those of arsenite.	arsenite	117-125	poly(ADP-ribose) polymerase 1	Homo sapiens	41-47
28552776-8	2017	Taken together, our findings indicate that arsenite interferes with PARP-1 and XPA binding to chromatin, and that zinc supplementation fully restores DNA binding activity to both proteins in the cellular context.	arsenite	43-51	poly(ADP-ribose) polymerase 1	Homo sapiens	68-74
28552776-8	2017	Taken together, our findings indicate that arsenite interferes with PARP-1 and XPA binding to chromatin, and that zinc supplementation fully restores DNA binding activity to both proteins in the cellular context.	arsenite	43-51	XPA, DNA damage recognition and repair factor	Homo sapiens	79-82
28552776-9	2017	Interestingly, rescue of arsenite-inhibited DNA damage repair by supplemental zinc was more sensitive for DNA damage repaired by the XPA-associated NER pathway than for the PARP-1-dependent BER pathway.	arsenite	25-33	XPA, DNA damage recognition and repair factor	Homo sapiens	133-136
28552776-9	2017	Interestingly, rescue of arsenite-inhibited DNA damage repair by supplemental zinc was more sensitive for DNA damage repaired by the XPA-associated NER pathway than for the PARP-1-dependent BER pathway.	arsenite	25-33	poly(ADP-ribose) polymerase 1	Homo sapiens	173-179
28936164-7	2017	Arsenite exposure also stimulated the expression of the endoplasmic reticulum (ER) stress markers, glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and the cleavage of caspase-12.	arsenite	0-8	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	99-127
28936164-7	2017	Arsenite exposure also stimulated the expression of the endoplasmic reticulum (ER) stress markers, glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and the cleavage of caspase-12.	arsenite	0-8	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	129-134
28936164-7	2017	Arsenite exposure also stimulated the expression of the endoplasmic reticulum (ER) stress markers, glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and the cleavage of caspase-12.	arsenite	0-8	DNA-damage inducible transcript 3	Rattus norvegicus	137-161
28936164-7	2017	Arsenite exposure also stimulated the expression of the endoplasmic reticulum (ER) stress markers, glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and the cleavage of caspase-12.	arsenite	0-8	DNA-damage inducible transcript 3	Rattus norvegicus	163-167
28936164-7	2017	Arsenite exposure also stimulated the expression of the endoplasmic reticulum (ER) stress markers, glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and the cleavage of caspase-12.	arsenite	0-8	caspase 12	Rattus norvegicus	189-199
28936164-8	2017	Furthermore, exposure to arsenite enhanced apoptosis as demonstrated by expression of caspase-3 and TUNEL assay in the hippocampus.	arsenite	25-33	caspase 3	Rattus norvegicus	86-95