PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28560258-8	2017	Our studies show that alterations in NMDAR function alter serum and brain lipid composition and make the brain more vulnerable to dietary omega-3 deprivation.	omega-3	138-145	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	37-42
27884155-10	2016	omega-3 and omega-3 + NDGA groups showed an inverse correlation with fasting blood glucose and showed lower plasma levels of GGT, TG, and CRP.	omega-3	0-7	C-reactive protein	Rattus norvegicus	138-141
28063515-6	2017	Individuals with a higher variation of adiponectin concentration after omega-3 supplementation presented with reduced blood glucose.	omega-3	71-78	adiponectin, C1Q and collagen domain containing	Homo sapiens	39-50
28063515-7	2017	The variation of serum adiponectin induced by omega-3 supplementation was negatively correlated with the Framingham and Adult Treatment Panel IV scores (r = -0.4 and P < 0.05 for both).	omega-3	46-53	adiponectin, C1Q and collagen domain containing	Homo sapiens	23-34
28063515-0	2017	The benefits of omega-3 supplementation depend on adiponectin basal level and adiponectin increase after the supplementation: A randomized clinical trial.	omega-3	16-23	adiponectin, C1Q and collagen domain containing	Homo sapiens	50-61
28063515-0	2017	The benefits of omega-3 supplementation depend on adiponectin basal level and adiponectin increase after the supplementation: A randomized clinical trial.	omega-3	16-23	adiponectin, C1Q and collagen domain containing	Homo sapiens	78-89
28218036-2	2017	Omega-3 polyunsaturated fatty acids and atorvastatin proved anti-inflammatory effects through peroxisome proliferator-activated receptor gamma mechanism.	omega-3	0-7	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	94-142
27884155-10	2016	omega-3 and omega-3 + NDGA groups showed an inverse correlation with fasting blood glucose and showed lower plasma levels of GGT, TG, and CRP.	omega-3	12-19	C-reactive protein	Rattus norvegicus	138-141
27248050-1	2016	Prevention of ischemia-reperfusion liver injury is achieved by a combined omega-3 and thyroid hormone (T3 ) protocol, which may involve peroxisome-proliferator activated receptor-alpha (PPAR-alpha)-fibroblast growth factor 21 (FGF21) signaling supporting energy requirements.	omega-3	74-81	peroxisome proliferator activated receptor alpha	Rattus norvegicus	136-184
27248050-1	2016	Prevention of ischemia-reperfusion liver injury is achieved by a combined omega-3 and thyroid hormone (T3 ) protocol, which may involve peroxisome-proliferator activated receptor-alpha (PPAR-alpha)-fibroblast growth factor 21 (FGF21) signaling supporting energy requirements.	omega-3	74-81	peroxisome proliferator activated receptor alpha	Homo sapiens	186-196
26621325-7	2016	In this review, we focus on our and other recent studies of the functions of sEH, including the effects of its eicosanoid products from both omega-3 and omega-6 PUFAs, in various metabolic diseases.	omega-3	141-148	epoxide hydrolase 2	Homo sapiens	77-80
27417579-3	2016	We hypothesized that inhibition of CYP2C activity will add to the protective effects of omega-3 LCPUFA on neovascular eye diseases.	omega-3	88-95	cytochrome P450, family 2, subfamily c, polypeptide 29	Mus musculus	35-40
27417579-5	2016	The plasma levels of omega-3 LCPUFA metabolites of CYP2C were determined by mass spectroscopy.	omega-3	21-28	cytochrome P450, family 2, subfamily c, polypeptide 29	Mus musculus	51-56
27417579-10	2016	Exposure to selected omega-3 LCPUFA metabolites of CYP2C significantly reversed the suppression of both angiogenesis ex vivo and endothelial cell functions in vitro by the CYP2C inhibitor montelukast.	omega-3	21-28	cytochrome P450, family 2, subfamily c, polypeptide 29	Mus musculus	51-56
27417579-10	2016	Exposure to selected omega-3 LCPUFA metabolites of CYP2C significantly reversed the suppression of both angiogenesis ex vivo and endothelial cell functions in vitro by the CYP2C inhibitor montelukast.	omega-3	21-28	cytochrome P450, family 2, subfamily c, polypeptide 29	Mus musculus	172-177
26888796-1	2016	BACKGROUND: GPR120 (FFAR4) is a G-protein coupled receptor implicated in the development of obesity and the antiinflammatory and insulin-sensitizing effects of omega-3 (omega-3) polyunsaturated fatty acids.	omega-3	160-167	free fatty acid receptor 4	Mus musculus	12-18
26888796-1	2016	BACKGROUND: GPR120 (FFAR4) is a G-protein coupled receptor implicated in the development of obesity and the antiinflammatory and insulin-sensitizing effects of omega-3 (omega-3) polyunsaturated fatty acids.	omega-3	160-167	free fatty acid receptor 4	Mus musculus	20-25
27679530-7	2016	Lipidomic analyses reveal that endoplasmic reticulum membranes from Plin2-null mice are markedly enriched in omega-3 and omega-6 long-chain polyunsaturated fatty acids, which others have shown inhibit SREBP activation and de novo lipogenesis.	omega-3	109-116	predicted gene 12551	Mus musculus	68-73
26975734-6	2016	It seems that the overall consequences of CYP epoxygenase activation largely depend on enzyme substrate preference and the endogenous Omega-3/Omega-6 PUFA ratio.	omega-3	134-141	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	42-45
27596261-1	2016	The objective of the present study was to evaluate the effect of omega-3 and omega-6 PUFA enriched diet on plasma IGF-1 and testosterone concentrations, puberty, sperm fatty acid profile and semen quality in male buffalo.	omega-3	65-72	insulin like growth factor 1	Bos taurus	114-119
29235764-3	2016	omega-3 PUFAs supplementation before and after transplantation of Guerin"s carcinoma resulted in the increase of NADH-cytochrome b5 reductase activity and decrease of cytochrome b5 level in the Guerin"s carcinoma microsomal fraction in the logarithmic phases of carcinogenesis as compared to the tumor-bearing rats.	omega-3	0-7	cytochrome b5 type A	Rattus norvegicus	118-131
29235764-3	2016	omega-3 PUFAs supplementation before and after transplantation of Guerin"s carcinoma resulted in the increase of NADH-cytochrome b5 reductase activity and decrease of cytochrome b5 level in the Guerin"s carcinoma microsomal fraction in the logarithmic phases of carcinogenesis as compared to the tumor-bearing rats.	omega-3	0-7	cytochrome b5 type A	Rattus norvegicus	167-180
27343314-8	2016	CONCLUSION: Omega-3 supplementation increased implantation markers Laminin and LIF and decreased epithelial height and microvilli thus seems to prepare the endometrium for a favorable environment of implantation.	omega-3	12-19	leukemia inhibitory factor	Mus musculus	79-82
26732065-6	2016	Caspase-3, calpain levels were decreased in ethanol + betaine, ethanol + omega-3, and ethanol + omega-3 + betaine groups compared to ethanol group.	omega-3	73-80	caspase 3	Rattus norvegicus	0-9
26732065-7	2016	Cathepsin B in ethanol + omega-3 + betaine group was decreased compared to ethanol, ethanol + betaine groups.	omega-3	25-32	cathepsin B	Rattus norvegicus	0-11
26828994-3	2016	Although agents such as omega-3 (omega3) and vitamin D3 (Vit D3) are known to contribute to the success of islet allo-transplantation (ITX), in this study we aimed to experimentally determine their effects on glycemia and TNF-alpha production.	omega-3	24-31	tumor necrosis factor	Rattus norvegicus	222-231
26011009-7	2015	Long-term therapy with omega-3 increased the regulatory protein MyoD and muscle regeneration and reduced markers of inflammation (TNF-alpha and NF-kB) in both muscles studied.	omega-3	23-30	myogenic differentiation 1	Mus musculus	64-68
26382010-7	2016	Women with gestational diabetes who received omega-3 had significantly lower serum C-reactive protein concentrations, low incidence of hyperbilirubinemia in newborns and decreased newborns" hospitalization rate.	omega-3	45-52	C-reactive protein	Homo sapiens	83-101
27110520-0	2015	Effect of Omega-3 Supplementation on Visfatin, Adiponectin, and Anthropometric Indices in Women with Polycystic Ovarian Syndrome.	omega-3	10-17	nicotinamide phosphoribosyltransferase	Homo sapiens	37-45
27110520-3	2015	The aim of this study was to determine the effect of omega-3 supplementation on visfatin, adiponectin, and anthropometric indices in PCOS women.	omega-3	53-60	nicotinamide phosphoribosyltransferase	Homo sapiens	80-88
27110520-3	2015	The aim of this study was to determine the effect of omega-3 supplementation on visfatin, adiponectin, and anthropometric indices in PCOS women.	omega-3	53-60	adiponectin, C1Q and collagen domain containing	Homo sapiens	90-101
27110520-10	2015	But, at the end of the study, the mean of adiponectin concentration increased (p<0.001) in omega-3 group.	omega-3	94-101	adiponectin, C1Q and collagen domain containing	Homo sapiens	42-53
27110520-16	2015	CONCLUSION: Our results showed that 8 weeks of supplementation of omega-3 may have some beneficial effects on PCOS biochemical characteristics such as LH, LH/FSH, and adiponectin.	omega-3	66-73	adiponectin, C1Q and collagen domain containing	Homo sapiens	167-178
26011009-7	2015	Long-term therapy with omega-3 increased the regulatory protein MyoD and muscle regeneration and reduced markers of inflammation (TNF-alpha and NF-kB) in both muscles studied.	omega-3	23-30	tumor necrosis factor	Mus musculus	130-139
26436081-5	2015	The aim of this study is evaluation of effect of omega-3 supplementation on IL-6 and CRP level in chronic ambulatory peritoneal dialysis (CAPD) patients.	omega-3	49-56	C-reactive protein	Homo sapiens	85-88
24408035-9	2015	Patients treated with parenteral omega-3 were associated with a significant reduction in new organ dysfunction (Delta-SOFA 2.2 +- 2.2 vs. 1.0 +- 1.5, P = .005 and maximum-SOFA 10.1 +- 4.2 vs. 8.1 +- 3.2, P = .041) and maximum CRP (186.7 +- 78 vs. 141.5 +- 62.6, P = .019).	omega-3	33-40	C-reactive protein	Homo sapiens	226-229
25691459-7	2015	These findings were extended by the demonstration that overexpressing miR-26a or miR-26b decreased 15-PGDH protein levels, reversed omega-3 PUFA-induced accumulation of 15-PGDH protein, and prevented omega-3 PUFA-induced inhibition of cholangiocarcinoma cell growth.	omega-3	132-139	microRNA 26a-1	Homo sapiens	70-77
25691459-7	2015	These findings were extended by the demonstration that overexpressing miR-26a or miR-26b decreased 15-PGDH protein levels, reversed omega-3 PUFA-induced accumulation of 15-PGDH protein, and prevented omega-3 PUFA-induced inhibition of cholangiocarcinoma cell growth.	omega-3	132-139	microRNA 26b	Homo sapiens	81-88
25691459-7	2015	These findings were extended by the demonstration that overexpressing miR-26a or miR-26b decreased 15-PGDH protein levels, reversed omega-3 PUFA-induced accumulation of 15-PGDH protein, and prevented omega-3 PUFA-induced inhibition of cholangiocarcinoma cell growth.	omega-3	132-139	carbonyl reductase 1	Homo sapiens	169-176
25986600-2	2015	Their antihypertensive action may be due to the reduction of the omega-6/omega-3 ratio and the resulting competitive effect of omega-3 as compared to arachidonic acid (an omega-6 PUFA) as a substrate of cytochrome P450 (CYP450) enzymes involved in the production of vasoactive mediators.	omega-3	127-134	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	203-218
25986600-2	2015	Their antihypertensive action may be due to the reduction of the omega-6/omega-3 ratio and the resulting competitive effect of omega-3 as compared to arachidonic acid (an omega-6 PUFA) as a substrate of cytochrome P450 (CYP450) enzymes involved in the production of vasoactive mediators.	omega-3	127-134	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	220-226
25833984-4	2015	OBJECTIVE: We examined the role of APN in ROP development and whether circulating APN concentrations are increased by dietary omega-3 LCPUFAs to mediate the protective effect in ROP.	omega-3	126-133	adiponectin, C1Q and collagen domain containing	Mus musculus	82-85
25833984-6	2015	Mouse OIR was then used to determine whether omega-3 LCPUFA supplementation increases serum APN concentrations, which then suppress retinopathy.	omega-3	45-52	adiponectin, C1Q and collagen domain containing	Mus musculus	92-95
25833984-7	2015	RESULTS: We found that in preterm infants, low serum APN concentrations positively correlate with ROP, and serum APN concentrations positively correlate with serum omega-3 LCPUFA concentrations.	omega-3	164-171	adiponectin, C1Q and collagen domain containing	Mus musculus	113-116
25833984-8	2015	In mouse OIR, serum total APN and bioactive high-molecular-weight APN concentrations are increased by omega-3 LCPUFA feed.	omega-3	102-109	adiponectin, C1Q and collagen domain containing	Mus musculus	26-29
25833984-8	2015	In mouse OIR, serum total APN and bioactive high-molecular-weight APN concentrations are increased by omega-3 LCPUFA feed.	omega-3	102-109	adiponectin, C1Q and collagen domain containing	Mus musculus	66-69
25833984-14	2015	CONCLUSION: Our findings suggest that increasing APN by omega-3 LCPUFA supplementation in total parental nutrition for preterm infants may suppress ROP.	omega-3	56-63	adiponectin, C1Q and collagen domain containing	Mus musculus	49-52
25585167-7	2015	A multivariate machine learning analysis, known as Gaussian Process Classification (GPC), confirmed that baseline fatty acids predicted response to treatment in the omega-3 PUFA group with high levels of sensitivity, specificity and accuracy.	omega-3	165-172	pumilio RNA binding family member 3	Homo sapiens	173-177
25577352-11	2015	In this study, we developed an accurate, precise, and novel analytical method for estimating the omega-6 and omega-3 PUFA metabolites, and this is the first report that the SPMs derived from EPA and DHA are present in human urine.	omega-3	109-116	pumilio RNA binding family member 3	Homo sapiens	117-121
25709631-0	2014	High omega-3:omega-6 fatty acids ratio increases fatty acid binding protein 4 and extracellular secretory phospholipase A2IIa in human ectopic endometrial cells.	omega-3	5-12	fatty acid binding protein 4	Homo sapiens	49-77
25523099-11	2014	The expression of inducible nitric oxide synthase (iNOS), which may reflect oxidative stress-induced tissue damage, was suppressed by omega-3 administration and adding UDCA further attenuated iNOS expression.	omega-3	134-141	nitric oxide synthase 2, inducible	Mus musculus	18-49
25523099-11	2014	The expression of inducible nitric oxide synthase (iNOS), which may reflect oxidative stress-induced tissue damage, was suppressed by omega-3 administration and adding UDCA further attenuated iNOS expression.	omega-3	134-141	nitric oxide synthase 2, inducible	Mus musculus	51-55
25484856-0	2014	Long-term omega-3 supplementation modulates behavior, hippocampal fatty acid concentration, neuronal progenitor proliferation and central TNF-alpha expression in 7 month old unchallenged mice.	omega-3	10-17	tumor necrosis factor	Mus musculus	138-147
25484856-6	2014	Our results show that a higher Omega-3:Omega-6 PUFA diet ratio increased hippocampal PUFA, increased anxiety, improved hippocampal dependent spatial memory and reduced hippocampal TNF-alpha levels compared to a low Omega-3:Omega-6 diet.	omega-3	31-38	tumor necrosis factor	Mus musculus	180-189
25484856-7	2014	Furthermore, serum TNF-alpha concentration was reduced in the higher Omega-3:Omega-6 PUFA ratio supplementation group while expression of the neuronal progenitor proliferation markers KI67 and doublecortin (DCX) was increased in the dentate gyrus as opposed to the low Omega-3:Omega-6 group.	omega-3	69-76	tumor necrosis factor	Mus musculus	19-28
29378101-6	2015	Patients with T2 DM and CAN were divided into 2 groups: patients of the 1st group (group of comparison, n=15) received standard glucose-lowering therapy; patients of the 2nd group (n=21) received one capsule/day of the omega-3 PUFA (~90% ethyl ester of PUFA (1000 mg), in particular eicosapentaenoic - 460 mg, docosahexaenoic acid - 380 mg and 4 mg alpha-tocopherol acetate) in addition to the standard therapy.	omega-3	219-226	pumilio RNA binding family member 3	Homo sapiens	227-231
25484856-7	2014	Furthermore, serum TNF-alpha concentration was reduced in the higher Omega-3:Omega-6 PUFA ratio supplementation group while expression of the neuronal progenitor proliferation markers KI67 and doublecortin (DCX) was increased in the dentate gyrus as opposed to the low Omega-3:Omega-6 group.	omega-3	269-276	doublecortin	Mus musculus	207-210
24190860-0	2014	Omega-3 PUFA supplementation and the response to evoked endotoxemia in healthy volunteers.	omega-3	0-7	pumilio RNA binding family member 3	Homo sapiens	8-12
25122651-9	2014	CONCLUSIONS: Collectively FABP3 regulates n-3 (omega-3) and n-6 (omega-6) polyunsaturated FA transport in trophoblasts and plays a pivotal role in fetal development.	omega-3	47-54	fatty acid binding protein 3, muscle and heart	Mus musculus	26-31
24842071-3	2014	The present study aimed to investigate the effects of diets with different omega-3/omega-6 ratio consumed over three generations on blood biochemical parameters and hepatic expression of Ppara- and Srebf1-related genes.	omega-3	75-82	peroxisome proliferator activated receptor alpha	Rattus norvegicus	187-192
24842071-3	2014	The present study aimed to investigate the effects of diets with different omega-3/omega-6 ratio consumed over three generations on blood biochemical parameters and hepatic expression of Ppara- and Srebf1-related genes.	omega-3	75-82	sterol regulatory element binding transcription factor 1	Rattus norvegicus	198-204
24957699-11	2014	Diet modifications, like intake of fish, omega-3 supplementation, adherence to a Mediterranean dietary pattern and coffee consumption also increase adiponectin levels.	omega-3	41-48	adiponectin, C1Q and collagen domain containing	Homo sapiens	148-159
24361617-10	2014	Prolonging omega-3 depletion until adulthood impaired striatum"s anti-oxidant resources and BDNF distribution in the SN, worsening dopaminergic cell degeneration.	omega-3	11-18	brain-derived neurotrophic factor	Rattus norvegicus	92-96
24559509-9	2014	Although 0.2% omega-3 EFAs alone group also had a significant improvement in corneal irregularity scores and IL-17, IL-10, and 4 HNE levels compared with the other groups, the efficacy was lower than 0.2% omega-3 mixture group.	omega-3	14-21	interleukin 17A	Mus musculus	109-114
24559509-9	2014	Although 0.2% omega-3 EFAs alone group also had a significant improvement in corneal irregularity scores and IL-17, IL-10, and 4 HNE levels compared with the other groups, the efficacy was lower than 0.2% omega-3 mixture group.	omega-3	14-21	interleukin 10	Mus musculus	116-121
24985009-5	2014	Minor allele homozygotes and heterozygotes of rs174455 in FADS3 gene had lower levels of 22:5 omega-3, 20:4 omega-6, and Delta5desaturase activity in patients with T2DM.	omega-3	94-101	fatty acid desaturase 3	Homo sapiens	58-63
24783984-6	2014	Special emphasis is given to the ability of aspirin to acetylate cyclooxygenases (especially COX-2) and thus to initiate a biochemical pathway leading to the generation of anti-inflammatory pro-resolving mediators synthesized from both omega-3 and omega-6 long-chain polyunsaturated fatty acids.	omega-3	236-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
24345766-7	2014	Omega-3 deficiency worsened the effects of TBI on anxiety-like behavior and potentiated a reduction of anxiolytic neuropeptide Y1 receptor (NPY1R).	omega-3	0-7	neuropeptide Y receptor Y1	Homo sapiens	114-138
24345766-7	2014	Omega-3 deficiency worsened the effects of TBI on anxiety-like behavior and potentiated a reduction of anxiolytic neuropeptide Y1 receptor (NPY1R).	omega-3	0-7	neuropeptide Y receptor Y1	Homo sapiens	140-145
24307768-0	2013	Agonistic approach of omega-3, omega-6 and its metabolites with BDNF: An in-silico study.	omega-3	22-29	brain derived neurotrophic factor	Homo sapiens	64-68
24711896-6	2014	RESULTS:  Catalase, GPX (Glutathione peroxidase), SOD (Superoxide dismutase) in groups that received omega-3 showed higher levels, but MDA (malondialdehyde) level was significantly decreased (P<0.05) in comparison with other experimental groups.	omega-3	101-108	catalase	Rattus norvegicus	10-18
25136638-6	2014	Omega-3 could significantly reduce VEGF with the presence of other baseline variables (Beta = -12.55; P = 0.012).	omega-3	0-7	vascular endothelial growth factor A	Homo sapiens	35-39
25136638-7	2014	CONCLUSION: The administration of omega-3 can effectively improve endothelial function in adolescents with metabolic syndrome by reducing the level of serum VEGF, as a major index for atherosclerosis progression and endothelial destabilization.	omega-3	34-41	vascular endothelial growth factor A	Homo sapiens	157-161
25136638-8	2014	Omega-3 can be proposed as a VEGF antagonist for improving endothelial function in metabolic syndrome.	omega-3	0-7	vascular endothelial growth factor A	Homo sapiens	29-33
24771368-0	2014	Effect of polyunsaturated fatty acids omega-3 on the induction of activity and expression of CYP1A1 and CYP1A2 genes in the liver of rats under the influence of indole-3-carbinol.	omega-3	38-45	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	93-99
24771368-0	2014	Effect of polyunsaturated fatty acids omega-3 on the induction of activity and expression of CYP1A1 and CYP1A2 genes in the liver of rats under the influence of indole-3-carbinol.	omega-3	38-45	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	104-110
24771368-4	2014	The indole-3-carbinol-induced expression of CYP1A2 mRNA slightly increased in animals receiving omega-3 PUFA.	omega-3	96-103	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	44-50
24144775-4	2014	Besides, omega-3 and, to a lesser extent, olmesartan treatments in a dose dependent manner attenuated CCl4-induced liver fibrosis, as demonstrated by hepatic histopathology scoring and 4-hydroxyproline content.	omega-3	9-16	C-C motif chemokine ligand 4	Rattus norvegicus	102-106
25003120-8	2014	Omega-3 supplementation normalized CBS and MTHFR mRNA levels.	omega-3	0-7	methylenetetrahydrofolate reductase	Rattus norvegicus	43-48
24639805-2	2013	OBJECTIVE: This study was conducted to determine the effect of omega-3 supplementation on sex hormone-binding protein (SHBG), testosterone, free androgen index (FAI) and menstrual status in women with PCOS.	omega-3	63-70	sex hormone binding globulin	Homo sapiens	90-117
23676336-6	2013	Our results show that omega-3 rich diet in combination with the sEH inhibitor lowered Ang-II, increased the blood pressure, further increased the renal levels of EPA and DHA epoxides, reduced renal markers of inflammation (ie, prostaglandins and MCP-1), downregulated an epithelial sodium channel, and upregulated angiotensin-converting enzyme-2 message and significantly modulated cyclooxygenase and lipoxygenase metabolic pathways.	omega-3	22-29	epoxide hydrolase 2, cytoplasmic	Mus musculus	64-67
23676336-6	2013	Our results show that omega-3 rich diet in combination with the sEH inhibitor lowered Ang-II, increased the blood pressure, further increased the renal levels of EPA and DHA epoxides, reduced renal markers of inflammation (ie, prostaglandins and MCP-1), downregulated an epithelial sodium channel, and upregulated angiotensin-converting enzyme-2 message and significantly modulated cyclooxygenase and lipoxygenase metabolic pathways.	omega-3	22-29	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	86-92
23676336-6	2013	Our results show that omega-3 rich diet in combination with the sEH inhibitor lowered Ang-II, increased the blood pressure, further increased the renal levels of EPA and DHA epoxides, reduced renal markers of inflammation (ie, prostaglandins and MCP-1), downregulated an epithelial sodium channel, and upregulated angiotensin-converting enzyme-2 message and significantly modulated cyclooxygenase and lipoxygenase metabolic pathways.	omega-3	22-29	mast cell protease 1	Mus musculus	246-251
23676336-6	2013	Our results show that omega-3 rich diet in combination with the sEH inhibitor lowered Ang-II, increased the blood pressure, further increased the renal levels of EPA and DHA epoxides, reduced renal markers of inflammation (ie, prostaglandins and MCP-1), downregulated an epithelial sodium channel, and upregulated angiotensin-converting enzyme-2 message and significantly modulated cyclooxygenase and lipoxygenase metabolic pathways.	omega-3	22-29	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	314-345
23584593-0	2013	Omega-3 polyunsaturated fatty acids increase plasma adiponectin to leptin ratio in stable coronary artery disease.	omega-3	0-7	adiponectin, C1Q and collagen domain containing	Homo sapiens	52-63
23584593-0	2013	Omega-3 polyunsaturated fatty acids increase plasma adiponectin to leptin ratio in stable coronary artery disease.	omega-3	0-7	leptin	Homo sapiens	67-73
24639805-2	2013	OBJECTIVE: This study was conducted to determine the effect of omega-3 supplementation on sex hormone-binding protein (SHBG), testosterone, free androgen index (FAI) and menstrual status in women with PCOS.	omega-3	63-70	sex hormone binding globulin	Homo sapiens	119-123
23874068-1	2013	UNLABELLED: The present study aimed to assess the effect of supplementation of omega-3 and/or vitamin C on serum interleukin-6 and high sensitivity C-reactive protein concentration and depression scores among shift workers in Shahid Tondgoyan oil refinery.	omega-3	79-86	interleukin 6	Homo sapiens	113-126
23849180-0	2013	Omega-3 and omega-6 PUFAs induce the same GPR120-mediated signalling events, but with different kinetics and intensity in Caco-2 cells.	omega-3	0-7	free fatty acid receptor 4	Homo sapiens	42-48
23438101-12	2013	Concerning the IR profile at the end of intervention, omega-3 significantly decreased the concentrations of glucose and insulin while reducing HOMA-IR values; meanwhile, Met negligibly affected insulin levels.	omega-3	54-61	insulin	Homo sapiens	120-127
23874068-1	2013	UNLABELLED: The present study aimed to assess the effect of supplementation of omega-3 and/or vitamin C on serum interleukin-6 and high sensitivity C-reactive protein concentration and depression scores among shift workers in Shahid Tondgoyan oil refinery.	omega-3	79-86	C-reactive protein	Homo sapiens	148-166
23874068-6	2013	Supplementation of omega-3 without vitamin C, is associated with a reduction in depression score (p<0.0001) and high sensitivity C-reactive protein concentration (p<0.01).	omega-3	19-26	C-reactive protein	Homo sapiens	132-150
23874068-7	2013	Therefore omega-3 supplementation showed a better effect on reducing depression score and high sensitivity C-reactive protein, but supplementation of vitamin C along with omega-3 did not have significant effect on change in C-reactive protein level compared to omega-3 alone.	omega-3	10-17	C-reactive protein	Homo sapiens	107-125
23589922-0	2013	Cardioprotective modulation of cardiac adiponectin and adiponectin receptors by omega-3 in the high-fat fed rats.	omega-3	80-87	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	39-50
23684444-9	2013	These studies showed that omega-3 treatment significantly decreased myeloperoxidase release, presented no cytotoxicity, and did not alter lipid peroxidation.	omega-3	26-33	myeloperoxidase	Homo sapiens	68-83
23698162-3	2013	In summary, dietary fatty acids, in particular saturated fatty acids and the omega-3 and omega-6 polyunsaturated fatty acids, impact the expression of the cytokine genes TNFA and IL-6, and alter TNFalpha and IL-6 production.	omega-3	77-84	tumor necrosis factor	Homo sapiens	170-174
23589922-0	2013	Cardioprotective modulation of cardiac adiponectin and adiponectin receptors by omega-3 in the high-fat fed rats.	omega-3	80-87	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	55-66
23589922-2	2013	This study investigated the effects of omega-3 (omega-3) on reversal of high fat (HF) diet-induced changes in the expression of the cardiac adiponectin and adiponectin receptors R1 and R2.	omega-3	39-46	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	140-151
23589922-2	2013	This study investigated the effects of omega-3 (omega-3) on reversal of high fat (HF) diet-induced changes in the expression of the cardiac adiponectin and adiponectin receptors R1 and R2.	omega-3	48-55	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	140-151
23589922-2	2013	This study investigated the effects of omega-3 (omega-3) on reversal of high fat (HF) diet-induced changes in the expression of the cardiac adiponectin and adiponectin receptors R1 and R2.	omega-3	48-55	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	156-167
23589922-8	2013	In conclusion, dietary omega-3 supplementation has a beneficial effect on fat-induced cardiac dysfunction and insulin resistance partly through increasing adiponectin and adiponectin receptors expression in heart and adipose tissue.	omega-3	23-30	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	155-166
23589922-8	2013	In conclusion, dietary omega-3 supplementation has a beneficial effect on fat-induced cardiac dysfunction and insulin resistance partly through increasing adiponectin and adiponectin receptors expression in heart and adipose tissue.	omega-3	23-30	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	171-182
22954755-2	2012	We evaluated the efficacy of omega-3 in preventing ketamine-induced effects in an animal model of schizophrenia and its effect on brain-derived neurotrophic factor (BDNF).	omega-3	29-36	brain-derived neurotrophic factor	Rattus norvegicus	130-163
22398025-1	2013	The fatty acid desaturase (FADS) gene family at 11q12-13.1 includes FADS1 and FADS2, both known to mediate biosynthesis of omega-3 and omega-6 long-chain polyunsaturated fatty acids (LCPUFA).	omega-3	123-130	stearoyl-CoA desaturase	Homo sapiens	4-25
22398025-1	2013	The fatty acid desaturase (FADS) gene family at 11q12-13.1 includes FADS1 and FADS2, both known to mediate biosynthesis of omega-3 and omega-6 long-chain polyunsaturated fatty acids (LCPUFA).	omega-3	123-130	stearoyl-CoA desaturase	Homo sapiens	27-31
22398025-1	2013	The fatty acid desaturase (FADS) gene family at 11q12-13.1 includes FADS1 and FADS2, both known to mediate biosynthesis of omega-3 and omega-6 long-chain polyunsaturated fatty acids (LCPUFA).	omega-3	123-130	fatty acid desaturase 1	Homo sapiens	68-73
22398025-1	2013	The fatty acid desaturase (FADS) gene family at 11q12-13.1 includes FADS1 and FADS2, both known to mediate biosynthesis of omega-3 and omega-6 long-chain polyunsaturated fatty acids (LCPUFA).	omega-3	123-130	fatty acid desaturase 2	Homo sapiens	78-83
22930204-7	2012	AT omega-3 was further positively associated with serum apoA1, r = 0.29, p = 0.004, whereas AT omega-6 showed a negative association, r = -0.21, p = 0.040.	omega-3	3-10	apolipoprotein A1	Homo sapiens	56-61
23531329-8	2013	RESULTS: After adjusting for gestational age at delivery, birthweight, and mode of delivery, both omega-3 supplementation groups were associated with lower macrophage-derived chemokine/interferon-inducible protein-10 ratios than placebo (eicosapentaenoic acid: coefficient -1.8; 95% confidence interval [CI], -3.6 to -0.05; P = .04; docosahexaenoic acid: -2.0; 95% CI, -3.9 to -0.07; P = .04).	omega-3	98-105	C-C motif chemokine ligand 22	Homo sapiens	156-184
23550861-10	2013	Omega-3 may be also effective in improving hirsutism and insulin resistance in patients with PCOS.	omega-3	0-7	insulin	Homo sapiens	57-64
22954755-2	2012	We evaluated the efficacy of omega-3 in preventing ketamine-induced effects in an animal model of schizophrenia and its effect on brain-derived neurotrophic factor (BDNF).	omega-3	29-36	brain-derived neurotrophic factor	Rattus norvegicus	165-169
22451038-5	2012	We observed significant interaction between rs174547 and long-chain omega-3 PUFA intakes on LDL (P = 0.01); the C-allele was only associated with lower LDL among individuals in the lowest tertile of long-chain omega-3 PUFA intakes (P < 0.001).	omega-3	68-75	pumilio RNA binding family member 3	Homo sapiens	76-80
22748975-1	2012	The fatty acid desaturase genes (FADS1 and FADS2) code for enzymes required for synthesis of omega-3 and omega-6 long-chain polyunsaturated fatty acids (LCPUFA) important in the central nervous system, inflammatory response, and cardiovascular health.	omega-3	93-100	fatty acid desaturase 1	Homo sapiens	33-38
22748975-1	2012	The fatty acid desaturase genes (FADS1 and FADS2) code for enzymes required for synthesis of omega-3 and omega-6 long-chain polyunsaturated fatty acids (LCPUFA) important in the central nervous system, inflammatory response, and cardiovascular health.	omega-3	93-100	fatty acid desaturase 2	Homo sapiens	43-48
22701466-1	2012	The delta-5 and delta-6 desaturases (D5D and D6D), encoded by fatty acid desaturase 1 (FADS1) and 2 (FADS2) genes, respectively, are rate-limiting enzymes in the metabolism of omega-3 and omega-6 fatty acids.	omega-3	176-183	fatty acid desaturase 1	Homo sapiens	62-85
22701466-1	2012	The delta-5 and delta-6 desaturases (D5D and D6D), encoded by fatty acid desaturase 1 (FADS1) and 2 (FADS2) genes, respectively, are rate-limiting enzymes in the metabolism of omega-3 and omega-6 fatty acids.	omega-3	176-183	fatty acid desaturase 1	Homo sapiens	87-92
22701466-1	2012	The delta-5 and delta-6 desaturases (D5D and D6D), encoded by fatty acid desaturase 1 (FADS1) and 2 (FADS2) genes, respectively, are rate-limiting enzymes in the metabolism of omega-3 and omega-6 fatty acids.	omega-3	176-183	fatty acid desaturase 2	Homo sapiens	101-106
22451038-5	2012	We observed significant interaction between rs174547 and long-chain omega-3 PUFA intakes on LDL (P = 0.01); the C-allele was only associated with lower LDL among individuals in the lowest tertile of long-chain omega-3 PUFA intakes (P < 0.001).	omega-3	68-75	pumilio RNA binding family member 3	Homo sapiens	218-222
22523671-7	2012	In the females, omega-3 LCPUFA supplementation improved glucose tolerance by 39% (P = 0.04) and restored insulin concentration by 34% (P = 0.02) during IVGTT.	omega-3	16-23	insulin	Homo sapiens	105-112
22319624-11	2012	Omega-3, instead, induced plasminogen activator inhibitor 1 synthesis.	omega-3	0-7	serpin family E member 1	Homo sapiens	26-59
20934853-8	2011	The balance of dietary omega-3 and omega-6 PUFAs is an important determinant of their metabolic effects within the body, and accordingly we calculated the percentage of the total PUFA comprised of omega-3 PUFAs and referred to this as the PUFA Balance.	omega-3	197-204	pumilio RNA binding family member 3	Homo sapiens	179-183
21917707-9	2011	RESULTS: Both classes of PUFAs, omega-3 (omega-3) and omega-6 (omega-6), can cause a modest but very reproducible reduction of gene expression, protein production, and pump activity of MDR1.	omega-3	32-39	ATP binding cassette subfamily B member 1	Homo sapiens	185-189
21917707-9	2011	RESULTS: Both classes of PUFAs, omega-3 (omega-3) and omega-6 (omega-6), can cause a modest but very reproducible reduction of gene expression, protein production, and pump activity of MDR1.	omega-3	41-48	ATP binding cassette subfamily B member 1	Homo sapiens	185-189
20061930-0	2010	Omega-3 polyunsaturated fatty acids affect sirolimus exposure in kidney transplant recipients on calcineurin inhibitor-free regimen.	omega-3	0-7	calcineurin binding protein 1	Homo sapiens	97-118
22091264-0	2011	The effect of omega-3 on the serum visfatin concentration in patients with type II diabetes.	omega-3	14-21	nicotinamide phosphoribosyltransferase	Homo sapiens	35-43
22091264-3	2011	In the present study, the effect of Omega-3 on the serum visfatin concentration was evaluated.	omega-3	36-43	nicotinamide phosphoribosyltransferase	Homo sapiens	57-65
22091264-11	2011	CONCLUSIONS: This study showed an increase in visfatin level following consuming Omega-3 fats but according to controversial issues on insulin-like function of visfatin, the effects of Omega-3 on diabetes should be studied more in further studies.	omega-3	81-88	nicotinamide phosphoribosyltransferase	Homo sapiens	46-54
24149692-7	2010	Results indicated that consuming 1000 mg day(-1) omega-3 during 16 weeks and or the aerobic exercise, significantly increased CT (p = 0.001) in E+S, E and S groups and significantly decreased PTH (p = 0.001) levels in E+S and E groups, also significantly increased estrogen (p = 0.024) levels in E+S and E groups, but had no significant effects on blood Ca(+2) (p = 0.619) levels.	omega-3	49-56	calcitonin related polypeptide alpha	Homo sapiens	126-128
20971855-0	2011	Structural insight into the differential effects of omega-3 and omega-6 fatty acids on the production of Abeta peptides and amyloid plaques.	omega-3	52-59	amyloid beta precursor protein	Homo sapiens	105-110
24149692-7	2010	Results indicated that consuming 1000 mg day(-1) omega-3 during 16 weeks and or the aerobic exercise, significantly increased CT (p = 0.001) in E+S, E and S groups and significantly decreased PTH (p = 0.001) levels in E+S and E groups, also significantly increased estrogen (p = 0.024) levels in E+S and E groups, but had no significant effects on blood Ca(+2) (p = 0.619) levels.	omega-3	49-56	parathyroid hormone	Homo sapiens	192-195
24149692-8	2010	The results of present study demonstrate that omega-3 in combination with regular aerobic exercise training have significant effects on serum CT, estrogen and PTH in non-athletic post-menopausal women, suggesting that participating in moderate intensity weight-bearing exercise and incorporating sources of omega-3 in the diet a possible intervention to help slow the loss of bone that occurs following menopause.	omega-3	46-53	calcitonin related polypeptide alpha	Homo sapiens	142-144
24149692-8	2010	The results of present study demonstrate that omega-3 in combination with regular aerobic exercise training have significant effects on serum CT, estrogen and PTH in non-athletic post-menopausal women, suggesting that participating in moderate intensity weight-bearing exercise and incorporating sources of omega-3 in the diet a possible intervention to help slow the loss of bone that occurs following menopause.	omega-3	46-53	parathyroid hormone	Homo sapiens	159-162
20336194-6	2010	MATERIALS AND METHODS: We studied the role of ER status on the gene expression in breast cancer cells in response to omega-3 and omega-6 fatty acids using microarrays.	omega-3	117-124	estrogen receptor 1	Homo sapiens	3-5
21291825-0	2009	Regulation of human stearoyl-CoA desaturase by omega-3 and omega-6 fatty acids: Implications for the dietary management of elevated serum triglycerides.	omega-3	47-54	stearoyl-CoA desaturase	Homo sapiens	20-43
16934876-0	2006	Effects of acute or chronic omega-3 and omega-6 polyunsaturated fatty acid treatment on behavioral, neuroendocrine and cytokine changes elicited by exogenous interleukin-1beta challenge.	omega-3	28-35	interleukin 1 beta	Homo sapiens	158-175
18991244-7	2008	Consumption of omega-3 enriched eggs resulted in higher levels of ApoA1, lower ApoB/ApoA1 ratio and lower plasma glucose.	omega-3	15-22	apolipoprotein A1	Homo sapiens	66-71
18991244-7	2008	Consumption of omega-3 enriched eggs resulted in higher levels of ApoA1, lower ApoB/ApoA1 ratio and lower plasma glucose.	omega-3	15-22	apolipoprotein B	Homo sapiens	79-83
18991244-7	2008	Consumption of omega-3 enriched eggs resulted in higher levels of ApoA1, lower ApoB/ApoA1 ratio and lower plasma glucose.	omega-3	15-22	apolipoprotein A1	Homo sapiens	84-89
17683870-8	2007	The increases in brain phosphatides in gerbils receiving an omega-3 (but not omega-6) fatty acid, with or without UMP, were accompanied by parallel elevations in levels of pre- and post-synaptic proteins (syntaxin-3, PSD-95 and synapsin-1) but not in those of a ubiquitous structural protein, beta-tubulin.	omega-3	60-67	syntaxin 3	Homo sapiens	205-215
19480565-0	2009	Effects of omega-3 and omega-6 fatty acids on IGF-I receptor signalling in colorectal cancer cells.	omega-3	11-18	insulin like growth factor 1 receptor	Homo sapiens	46-60
19480565-9	2009	In summary, our results provide evidence that omega-3 and omega-6 fatty acids modulate IGF-I action in colon cancer cells.	omega-3	46-53	insulin like growth factor 1	Homo sapiens	87-92
19221048-7	2009	RESULTS: We found that the ratio of interfero omega-gamma (IFN-gamma) / interleukin-4 (IL-4) was significantly higher in mice fed the omega-3 rich diet than in others.	omega-3	134-141	interferon gamma	Mus musculus	59-68
19221048-7	2009	RESULTS: We found that the ratio of interfero omega-gamma (IFN-gamma) / interleukin-4 (IL-4) was significantly higher in mice fed the omega-3 rich diet than in others.	omega-3	134-141	interleukin 4	Mus musculus	72-85
19221048-7	2009	RESULTS: We found that the ratio of interfero omega-gamma (IFN-gamma) / interleukin-4 (IL-4) was significantly higher in mice fed the omega-3 rich diet than in others.	omega-3	134-141	interleukin 4	Mus musculus	87-91
19568414-15	2009	Together, these observations provide mechanistic roles of omega-3 fatty acids in slowing prostate cancer growth by altering omega-6/omega-3 ratios through diet and by promoting apoptosis and inhibiting proliferation in tumors by directly competing with omega-6 fatty acids for 15-LO-1 and COX-2 activities.	omega-3	58-65	prostaglandin-endoperoxide synthase 2	Mus musculus	289-294
17605061-3	2007	In this study, the effects of omega-3 and omega-6 PUFA on lipopolysaccharide induced TNF-alpha and interleukin (IL)-10 secretion by murine primary resident and elicited peritoneal macrophages and by RAW 264.7 macrophages, were examined in vitro using an enzyme-linked immunosorbent assay.	omega-3	30-37	tumor necrosis factor	Mus musculus	85-94
17605061-3	2007	In this study, the effects of omega-3 and omega-6 PUFA on lipopolysaccharide induced TNF-alpha and interleukin (IL)-10 secretion by murine primary resident and elicited peritoneal macrophages and by RAW 264.7 macrophages, were examined in vitro using an enzyme-linked immunosorbent assay.	omega-3	30-37	interleukin 10	Mus musculus	99-118
17059813-14	2007	In addition, only omega-3 PUFA inhibits NCX1.1, but several classes of fatty acids inhibit NCX1.3.	omega-3	18-25	solute carrier family 8 member A1	Homo sapiens	40-44
16934876-1	2006	Chronic omega-3 or omega-6 polyunsaturated fatty acid (n-3; n-6 respectively) treatment attenuated human interleukin-1beta (hIL-1beta; 5.0 microg/kg)-elicited rise of circulating ACTH levels and attenuated the sickness behavior and locomotor suppression elicited by the cytokine.	omega-3	8-15	interleukin 1 beta	Homo sapiens	105-122
16934876-1	2006	Chronic omega-3 or omega-6 polyunsaturated fatty acid (n-3; n-6 respectively) treatment attenuated human interleukin-1beta (hIL-1beta; 5.0 microg/kg)-elicited rise of circulating ACTH levels and attenuated the sickness behavior and locomotor suppression elicited by the cytokine.	omega-3	8-15	interleukin 1 beta	Homo sapiens	124-133
16934876-1	2006	Chronic omega-3 or omega-6 polyunsaturated fatty acid (n-3; n-6 respectively) treatment attenuated human interleukin-1beta (hIL-1beta; 5.0 microg/kg)-elicited rise of circulating ACTH levels and attenuated the sickness behavior and locomotor suppression elicited by the cytokine.	omega-3	8-15	proopiomelanocortin	Homo sapiens	179-183
16547139-2	2006	Biophysical experiments have shown that lipid unsaturation and cholesterol both have significant effects on rhodopsin"s stability and function; omega-3 polyunsaturated chains, such as docosahexaenoic acid (DHA), destabilize rhodopsin and enhance the kinetics of the photocycle, whereas cholesterol has the opposite effect.	omega-3	144-151	rhodopsin	Homo sapiens	108-117
16598260-0	2006	Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3.	omega-3	0-7	syntaxin 3	Homo sapiens	79-89
15987770-3	2005	In this study we have analyzed the effects of arachidonic acid (AA, omega-6) and docosahexaenoic acid (DHA, omega-3) on HERG channels stably expressed in Chinese hamster ovary cells by using the whole cell patch-clamp technique.	omega-3	108-115	potassium voltage-gated channel subfamily H member 2	Homo sapiens	120-124
12111278-6	2002	Giving a polyunsaturated fatty acid (omega-3) supplemented diet for eight weeks induced a large rise of the FABP(c) in EDL (300%), gastrocnemius (250%), soleus (50%) and heart (15%) without a concurrent accumulation of intramuscular triglycerides or modification of the citrate synthase activity, suggesting that polyunsaturated fatty acids may increase FABP(c) content by up-regulating fatty acid metabolism genes via peroxisome proliferator-activated receptor alpha activation.	omega-3	37-44	fatty acid binding protein 2	Rattus norvegicus	108-112
15291404-7	2004	RESULTS: TNF-alpha and PGE2 production was significantly decreased with omega-3 and Rofecoxib pretreatment, and with combination treatment a further decrease in TNF-alpha production was observed.	omega-3	72-79	tumor necrosis factor	Mus musculus	9-18
15291404-8	2004	COX-2 protein expression was demonstrated to increase in omega-3, Rofecoxib, and combination groups stimulated with LPS.	omega-3	57-64	cytochrome c oxidase II, mitochondrial	Mus musculus	0-5
15138577-3	2004	We have assessed the role of omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) on the enzymatic activity and protein expression of tumor-associated FAS in SK-Br3 human breast cancer cells, an experimental paradigm of FAS-overexpressing tumor cells in which FAS enzyme constitutes up to 28%, by weight, of the cytosolic proteins.	omega-3	29-36	fatty acid synthase	Homo sapiens	154-157
14637245-0	2003	Formation of trans-4-hydroxy-2-nonenal- and other enal-derived cyclic DNA adducts from omega-3 and omega-6 polyunsaturated fatty acids and their roles in DNA repair and human p53 gene mutation.	omega-3	87-94	tumor protein p53	Homo sapiens	175-178
12652939-2	2003	Omega-3 polyunsaturated fatty acid (PUFA) drugs enhance the formation of autoantibodies to modified ADH and decrease the activity of ADH in the stomach and liver.	omega-3	0-7	aldo-keto reductase family 1 member A1	Rattus norvegicus	100-103
12652939-2	2003	Omega-3 polyunsaturated fatty acid (PUFA) drugs enhance the formation of autoantibodies to modified ADH and decrease the activity of ADH in the stomach and liver.	omega-3	0-7	aldo-keto reductase family 1 member A1	Rattus norvegicus	133-136
12111278-6	2002	Giving a polyunsaturated fatty acid (omega-3) supplemented diet for eight weeks induced a large rise of the FABP(c) in EDL (300%), gastrocnemius (250%), soleus (50%) and heart (15%) without a concurrent accumulation of intramuscular triglycerides or modification of the citrate synthase activity, suggesting that polyunsaturated fatty acids may increase FABP(c) content by up-regulating fatty acid metabolism genes via peroxisome proliferator-activated receptor alpha activation.	omega-3	37-44	citrate synthase	Rattus norvegicus	270-286
12111278-6	2002	Giving a polyunsaturated fatty acid (omega-3) supplemented diet for eight weeks induced a large rise of the FABP(c) in EDL (300%), gastrocnemius (250%), soleus (50%) and heart (15%) without a concurrent accumulation of intramuscular triglycerides or modification of the citrate synthase activity, suggesting that polyunsaturated fatty acids may increase FABP(c) content by up-regulating fatty acid metabolism genes via peroxisome proliferator-activated receptor alpha activation.	omega-3	37-44	fatty acid binding protein 2	Rattus norvegicus	354-358
12111278-6	2002	Giving a polyunsaturated fatty acid (omega-3) supplemented diet for eight weeks induced a large rise of the FABP(c) in EDL (300%), gastrocnemius (250%), soleus (50%) and heart (15%) without a concurrent accumulation of intramuscular triglycerides or modification of the citrate synthase activity, suggesting that polyunsaturated fatty acids may increase FABP(c) content by up-regulating fatty acid metabolism genes via peroxisome proliferator-activated receptor alpha activation.	omega-3	37-44	peroxisome proliferator activated receptor alpha	Rattus norvegicus	419-467
12111278-8	2002	The FABP(c) in the soleus and in the heart of rats fed with omega-3 supplements remained constant whether rats performed exercise or not.	omega-3	60-67	fatty acid binding protein 2	Rattus norvegicus	4-8
12111278-9	2002	As a result, both exercise and omega-3-enriched diet influenced FABP(c) content in muscle.	omega-3	31-38	fatty acid binding protein 2	Rattus norvegicus	64-68
11054425-2	2001	In the present study, we observed that alpha-naphthoflavone (alpha-NF) exhibited a differential effect on CYP3A4-mediated product formation as shown by an increase and decrease, respectively, of the carboxylic acid (P(2)) and omega-3-hydroxylated (P(1)) metabolites of losartan, while losartan was found to be an inhibitor of the formation of the 5,6-epoxide of alpha-NF.	omega-3	226-233	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	106-112
12032170-7	2002	We conclude that short-term TNFalpha incubation of HUVEC causes an EFAD state hitherto only described for long-term malnutrition, and that endothelial cells are susceptible to differential influence by omega-3 versus omega-6 FA supplementation under these conditions.	omega-3	202-209	tumor necrosis factor	Homo sapiens	28-36
11591404-1	2001	OBJECTIVE: To study the effects of omega-3 and omega-6 polyunsaturated fatty acid (PUFA) on in vitro proliferation of endometrial cells and their production of the cytokine interleukin-8 (IL-8).	omega-3	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	173-186
11591404-8	2001	Endometrial cells from women with endometriosis secreted higher concentrations of IL-8, especially in the presence of high omega-3:omega-6 PUFA ratios.	omega-3	123-130	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
9680669-2	1998	Against a background of positive influence on clinical symptoms of diseases, lipids of blood serum, homeostasis expressed influence of PUFA omega-3 in "Eikovit" on biomembrane fat acid composition was noted.	omega-3	140-147	pumilio RNA binding family member 3	Homo sapiens	135-139
11452365-2	2000	Estimation of serum PUFA of omega-6 and omega-3 series in Nganasans testifies to shifting of their diet to "western" type.	omega-3	40-47	pumilio RNA binding family member 3	Homo sapiens	20-24
9829609-17	1998	omega-3 fat emulsion reduced IL-8 and IL-10 levels and prevented immunosuppression in burned rats that were receiving TPN.	omega-3	0-7	interleukin 10	Rattus norvegicus	38-43
9719086-0	1998	Effects of monounsaturated and polyunsaturated fatty acids (omega-3 and omega-6) on Brca1 protein expression in breast cell lines.	omega-3	60-67	BRCA1 DNA repair associated	Homo sapiens	84-89
11247166-1	2000	It was investigated the influence of a diet supplemented with PUFA omega-3 ("Eiconol") on dynamic of basal and postprandial glycemia, blood pressure, lipid levels, parameters of lipid peroxidation in 60 patients with non-insulin-dependent diabetes mellitus.	omega-3	67-74	pumilio RNA binding family member 3	Homo sapiens	62-66
9680670-0	1998	[Effect of anti-atherosclerotic diet with polyunsaturated fatty acids omega-3 from linseed oil on dynamics of natural antibodies to bradykinin and angiotensin II in blood serum of patients with cardiovascular diseases].	omega-3	70-77	kininogen 1	Homo sapiens	132-142
9680670-0	1998	[Effect of anti-atherosclerotic diet with polyunsaturated fatty acids omega-3 from linseed oil on dynamics of natural antibodies to bradykinin and angiotensin II in blood serum of patients with cardiovascular diseases].	omega-3	70-77	angiotensinogen	Homo sapiens	147-161
9037020-7	1997	By contrast, fat-1 transgenic plants efficiently desaturated both of these fatty acids to the corresponding omega-3 products.	omega-3	108-115	Omega-3 fatty acid desaturase fat-1	Caenorhabditis elegans	13-18
9329764-5	1997	Omega-3 PUFA reduce fasting and postprandial TG, may improve insulin sensitivity (as shown in animal experiments), decrease platelet and leukocyte reactivity, alter immunological functions, and may slightly decrease blood pressure.	omega-3	0-7	pumilio RNA binding family member 3	Homo sapiens	8-12
1494711-4	1992	Supplementing the diet with essential fatty acids (omega-3 and/or omega-6) may inhibit the production of some of the mediators of inflammation, such as leukotriene-B4 and interleukin-1.	omega-3	51-58	interleukin 1 alpha	Homo sapiens	171-184
8521454-14	1995	Fatty acids belonging to the omega-3, omega-6 and omega-7 unsaturated fatty acid families were effective in elevating [Ca2+]i and stimulating beta-glucuronidase release.	omega-3	29-36	glucuronidase beta	Homo sapiens	142-160
8192673-11	1994	The results suggest that dietary omega-3 and polyunsaturated fatty acids increase insulin binding to sarcolemma by changing the fatty acyl composition of phospholipid surrounding the insulin receptor, and this might be the mechanism by which dietary fatty acids modify insulin action.	omega-3	33-40	insulin receptor	Rattus norvegicus	183-199
8330345-2	1993	In the present study, we investigated the modulating effect of high-fat diets rich in omega-3, omega-6 and omega-9 fatty acids on liver, colon and small intestine mucosal ornithine decarboxylase (ODC) and tyrosine-specific protein kinase (TPK) activities and plasma, liver and colon mucosal prostaglandin E2 (PGE2) and 6-keto prostaglandin F1 alpha (6-keto PGF1 alpha) levels in male F344 rats.	omega-3	86-93	ornithine decarboxylase 1	Rattus norvegicus	171-194
1961121-6	1991	After omega-3 supplementation, both HDL2 and HDL3 became cholesteryl ester (CE)- and TG-enriched and free cholesterol (FC)- and phospholipid (PL)-depleted.	omega-3	6-13	junctophilin 3	Homo sapiens	36-40
1961121-6	1991	After omega-3 supplementation, both HDL2 and HDL3 became cholesteryl ester (CE)- and TG-enriched and free cholesterol (FC)- and phospholipid (PL)-depleted.	omega-3	6-13	HDL3	Homo sapiens	45-49
33350083-2	2018	However, recent advances with transglutaminase (TGase) enzyme as an effective protein cross-linker could provide workable solutions for the encapsulation of omega-3 and omega-6 fatty acids without compromising their targeted release and their biological and physicochemical characteristics.	omega-3	157-164	transglutaminase 1	Homo sapiens	30-46
25394692-11	2015	Intervention with diet plus omega-3 was associated with significant reduction in systolic (< 12.2%) and diastolic (< 8.2%) blood pressure, serum triglyceride concentration (< 21.4%), and insulin resistance (< 13.1%) (p < 0.05), as well as a reduction in serum IL-6 concentration (< 28.5%) (p = 0.034).	omega-3	28-35	insulin	Homo sapiens	196-203
25394692-11	2015	Intervention with diet plus omega-3 was associated with significant reduction in systolic (< 12.2%) and diastolic (< 8.2%) blood pressure, serum triglyceride concentration (< 21.4%), and insulin resistance (< 13.1%) (p < 0.05), as well as a reduction in serum IL-6 concentration (< 28.5%) (p = 0.034).	omega-3	28-35	interleukin 6	Homo sapiens	275-279
25394692-12	2015	CONCLUSION: In postmenopausal women with metabolic syndrome, dietary intervention plus supplementation of omega-3 resulted in a further decrease in triglycerides and blood pressure and also in an improvement in insulin resistance and inflammatory markers, important components of metabolic syndrome.	omega-3	106-113	insulin	Homo sapiens	211-218
33350083-2	2018	However, recent advances with transglutaminase (TGase) enzyme as an effective protein cross-linker could provide workable solutions for the encapsulation of omega-3 and omega-6 fatty acids without compromising their targeted release and their biological and physicochemical characteristics.	omega-3	157-164	transglutaminase 1	Homo sapiens	48-53
34721760-8	2021	The percentage of blood NETs relative to leukocytes (NETbackground) before vitamin D3/omega-3 PUFA supplementation was 3.2%-4.9% in healthy subjects and 1.7%-10.8% in patients.	omega-3	86-93	pumilio RNA binding family member 3	Homo sapiens	94-98
23214138-1	2012	Polyunsaturated fatty acids omega-3 (PUFA omega-3), in particular eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), are bioactive lipids that positively impact signaling pathways involved in the development of cardiovascular diseases.	omega-3	28-35	pumilio RNA binding family member 3	Homo sapiens	37-41
34743796-6	2022	omega-3 and omega-6 PUFAs demonstrated excellent linearities between the concentrations between 0.1-10,000 ng mL-1 with good regression coefficients between 0.9910-0.9997.	omega-3	0-7	L1 cell adhesion molecule	Mus musculus	110-114
34721760-14	2021	The decreased ability of neutrophils to generate NETs, which can be achieved by vitamin D3/omega-3 PUFA supplementation, could have a positive effect on wound healing in T2DM patients and reduce the incidence and severity of complications.	omega-3	91-98	pumilio RNA binding family member 3	Homo sapiens	99-103
34349613-9	2021	The mucus SIgA and serum IL-10 levels were increased, and serum levels of LPS, IL-1beta, and TNF-alpha were decreased in the 60- and 90-mg omega-3 PUFA groups when compared with those in the ceftriaxone sodium-treated group.	omega-3	139-146	interleukin 10	Mus musculus	25-30
34539977-5	2021	METHODS: A systematic literature search of PubMed, Embase and the Cochrane Library from inception to September 31, 2019 was conducted to identify the randomized controlled trails (RCTs) of omega-3 PUFA supplementation, which reported cardiovascular events or deaths and recruited no less than 500 participants.	omega-3	189-196	pumilio RNA binding family member 3	Homo sapiens	197-201
34499923-5	2022	Recent reports indicate that HO-1 with its antioxidants via the effect of bilirubin increases formation of biologically active lipid metabolites such as epoxyeicosatrienoic acid (EET), omega-3 and other polyunsaturated fatty acids (PUFAs).	omega-3	185-192	heme oxygenase 1	Homo sapiens	29-33
34349613-9	2021	The mucus SIgA and serum IL-10 levels were increased, and serum levels of LPS, IL-1beta, and TNF-alpha were decreased in the 60- and 90-mg omega-3 PUFA groups when compared with those in the ceftriaxone sodium-treated group.	omega-3	139-146	interleukin 1 alpha	Mus musculus	79-87
34349613-9	2021	The mucus SIgA and serum IL-10 levels were increased, and serum levels of LPS, IL-1beta, and TNF-alpha were decreased in the 60- and 90-mg omega-3 PUFA groups when compared with those in the ceftriaxone sodium-treated group.	omega-3	139-146	tumor necrosis factor	Mus musculus	93-102
35101812-4	2022	The balance between omega-3 and omega-6 levels in the cell membrane has a critical role in regulating the equilibrium between proinflammatory and antiinflammatory processes and inducing IL-6 production.	omega-3	20-27	interleukin 6	Homo sapiens	186-190
34356309-5	2021	In the present review, we provide evidence that different nutraceuticals, such as Hypericum perforatum (hypericin and hyperforin), flavonoids such as hesperidin, omega-3, and carnosine, can target TGF-beta1 signaling and increase TGF-beta1 production in the central nervous system as well as cognitive function.	omega-3	162-169	transforming growth factor beta 1	Homo sapiens	230-239
34474084-9	2021	This study provides the first comprehensive picture of the unique substrate selectivity of each PLA2 for omega-3 and omega-6 fatty acids.	omega-3	105-112	phospholipase A2 group VI	Homo sapiens	96-100
34356309-5	2021	In the present review, we provide evidence that different nutraceuticals, such as Hypericum perforatum (hypericin and hyperforin), flavonoids such as hesperidin, omega-3, and carnosine, can target TGF-beta1 signaling and increase TGF-beta1 production in the central nervous system as well as cognitive function.	omega-3	162-169	transforming growth factor beta 1	Homo sapiens	197-206
34257810-3	2021	The administration of omega-3 or omega-6 resulted in decreased serum concentrations of kisspeptin 1, gonadotropin-releasing hormone, luteinizing hormone, follicle-stimulating hormone, and testosterone.	omega-3	22-29	KiSS-1 metastasis-suppressor	Rattus norvegicus	87-99
34257810-5	2021	The intratesticular levels of apelin, adiponectin, and irisin were elevated while chemerin, leptin, resistin, vaspin, and visfatin were declined following the administration of either omega-3 or omega-6.	omega-3	184-191	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	38-49
34257810-5	2021	The intratesticular levels of apelin, adiponectin, and irisin were elevated while chemerin, leptin, resistin, vaspin, and visfatin were declined following the administration of either omega-3 or omega-6.	omega-3	184-191	retinoic acid receptor responder 2	Rattus norvegicus	82-90
34257810-5	2021	The intratesticular levels of apelin, adiponectin, and irisin were elevated while chemerin, leptin, resistin, vaspin, and visfatin were declined following the administration of either omega-3 or omega-6.	omega-3	184-191	leptin	Rattus norvegicus	92-98
34257810-5	2021	The intratesticular levels of apelin, adiponectin, and irisin were elevated while chemerin, leptin, resistin, vaspin, and visfatin were declined following the administration of either omega-3 or omega-6.	omega-3	184-191	serpin family A member 12	Rattus norvegicus	110-116
34257810-5	2021	The intratesticular levels of apelin, adiponectin, and irisin were elevated while chemerin, leptin, resistin, vaspin, and visfatin were declined following the administration of either omega-3 or omega-6.	omega-3	184-191	nicotinamide phosphoribosyltransferase	Rattus norvegicus	122-130
34257810-6	2021	The testicular concentration of interleukin 10 was increased while interleukin 1 beta, interleukin 6, tumor necrosis factor alpha, and nuclear factor kappa B were decreased after consumption of omega-3 or omega-6.	omega-3	194-201	interleukin 10	Rattus norvegicus	32-46
34257810-6	2021	The testicular concentration of interleukin 10 was increased while interleukin 1 beta, interleukin 6, tumor necrosis factor alpha, and nuclear factor kappa B were decreased after consumption of omega-3 or omega-6.	omega-3	194-201	interleukin 1 beta	Rattus norvegicus	67-85
34257810-6	2021	The testicular concentration of interleukin 10 was increased while interleukin 1 beta, interleukin 6, tumor necrosis factor alpha, and nuclear factor kappa B were decreased after consumption of omega-3 or omega-6.	omega-3	194-201	interleukin 6	Rattus norvegicus	87-100
34257810-6	2021	The testicular concentration of interleukin 10 was increased while interleukin 1 beta, interleukin 6, tumor necrosis factor alpha, and nuclear factor kappa B were decreased after consumption of omega-3 or omega-6.	omega-3	194-201	tumor necrosis factor	Rattus norvegicus	102-129
34174018-0	2021	Prenatal intake of omega-3 promotes Wnt/beta-catenin signaling pathway, and preserves integrity of the blood-brain barrier in preeclamptic rats.	omega-3	19-26	catenin beta 1	Rattus norvegicus	40-52
34174018-4	2021	We investigate the protective effect of omega-3 against neurovascular complication of preeclampsia and its relation to Wnt/beta-catenin signaling pathway.	omega-3	40-47	catenin beta 1	Rattus norvegicus	123-135
34174018-7	2021	RESULTS: We found that omega-3 supplementation significantly improved cognitive functions and EEG amplitude, decreased blood pressure, water contents of brain tissues, sFlt-1, oxidative stress, proteinuria, and enhanced Wnt\beta-catenin proteins.	omega-3	23-30	catenin beta 1	Rattus norvegicus	224-236
34174018-8	2021	Histological examination showed improved cerebral microangiopathy, increased expression of claudin-1 and -3, CD31, and VEGF in the cerebral cortical microvasculature and choroid plexus in PE rats treated with omega-3.	omega-3	209-216	claudin 1	Rattus norvegicus	91-107
34174018-8	2021	Histological examination showed improved cerebral microangiopathy, increased expression of claudin-1 and -3, CD31, and VEGF in the cerebral cortical microvasculature and choroid plexus in PE rats treated with omega-3.	omega-3	209-216	platelet and endothelial cell adhesion molecule 1	Rattus norvegicus	109-113
34174018-8	2021	Histological examination showed improved cerebral microangiopathy, increased expression of claudin-1 and -3, CD31, and VEGF in the cerebral cortical microvasculature and choroid plexus in PE rats treated with omega-3.	omega-3	209-216	vascular endothelial growth factor A	Rattus norvegicus	119-123
35467177-7	2022	Bladders from omega-3-treated rats showed lower expression ofKI-67 (p < 0.05), VEGF (p < 0.001) and IL-6 (p < 0.001) and significant higher expression of mi-RNA (p < 0.001).	omega-3	14-21	vascular endothelial growth factor A	Rattus norvegicus	79-83
35467177-7	2022	Bladders from omega-3-treated rats showed lower expression ofKI-67 (p < 0.05), VEGF (p < 0.001) and IL-6 (p < 0.001) and significant higher expression of mi-RNA (p < 0.001).	omega-3	14-21	interleukin 6	Rattus norvegicus	100-104
35405946-5	2022	Loss of adiponectin (APN) in mice (mimicking the low APN levels in Phase I ROP) decreased LCPUFA levels (including omega-3 and omega-6) in retinas under normoglycemic and hyperglycemic conditions.	omega-3	115-122	adiponectin, C1Q and collagen domain containing	Mus musculus	8-19
35405946-5	2022	Loss of adiponectin (APN) in mice (mimicking the low APN levels in Phase I ROP) decreased LCPUFA levels (including omega-3 and omega-6) in retinas under normoglycemic and hyperglycemic conditions.	omega-3	115-122	adiponectin, C1Q and collagen domain containing	Mus musculus	21-24
35405946-6	2022	omega-3 (vs. omega-6) LCPUFA activated the APN pathway by increasing the circulating APN levels and inducing expression of the retinal APN receptor.	omega-3	0-7	adiponectin, C1Q and collagen domain containing	Mus musculus	43-46
35405946-6	2022	omega-3 (vs. omega-6) LCPUFA activated the APN pathway by increasing the circulating APN levels and inducing expression of the retinal APN receptor.	omega-3	0-7	adiponectin, C1Q and collagen domain containing	Mus musculus	85-88
35268031-0	2022	FADS1 and FADS2 Gene Polymorphisms Modulate the Relationship of Omega-3 and Omega-6 Fatty Acid Plasma Concentrations in Gestational Weight Gain: A NISAMI Cohort Study.	omega-3	64-71	fatty acid desaturase 1	Homo sapiens	0-5
35260009-0	2022	Synergistic hepatoprotective effects of omega-3 and omega-6 fatty acids from Indian flax and sesame seed oils against CCl4-induced oxidative stress-mediated liver damage in rats.	omega-3	40-47	C-C motif chemokine ligand 4	Rattus norvegicus	118-122
35268031-0	2022	FADS1 and FADS2 Gene Polymorphisms Modulate the Relationship of Omega-3 and Omega-6 Fatty Acid Plasma Concentrations in Gestational Weight Gain: A NISAMI Cohort Study.	omega-3	64-71	fatty acid desaturase 2	Homo sapiens	10-15
35095496-8	2021	We also used a soluble epoxide hydrolase inhibitor (sEH) to potentiate the effects of omega-3 PUFA, since sEH inhibitors have been shown to stabilize the anti-inflammatory P450 metabolites derived from both omega-3 and omega-6 PUFA and promote generation of specialized pro-resolving lipid mediators from omega-3 PUFA.	omega-3	207-214	epoxide hydrolase 2, cytoplasmic	Mus musculus	106-109
33875799-8	2021	Omega-3 also reduced overall cortisol (p = 0.03) and IL-6 (p = 0.03) throughout the stressor; the 2.5 g/d group had 19% and 33% lower overall cortisol levels and IL-6 geometric mean levels, respectively, compared to the placebo group.	omega-3	0-7	interleukin 6	Homo sapiens	53-57
35095496-5	2021	To prevent any confounding factors that comes with dietary supplementation of omega-3 PUFA (different sources, purity, dose, and duration), we employed a Fat-1 transgenic mouse model that convert omega-6 PUFA to omega-3 PUFA, leading to a tissue omega-6 to omega-3 PUFA ratio of approximately 1:1.	omega-3	212-219	FAT atypical cadherin 1	Mus musculus	154-159
35095496-5	2021	To prevent any confounding factors that comes with dietary supplementation of omega-3 PUFA (different sources, purity, dose, and duration), we employed a Fat-1 transgenic mouse model that convert omega-6 PUFA to omega-3 PUFA, leading to a tissue omega-6 to omega-3 PUFA ratio of approximately 1:1.	omega-3	257-264	FAT atypical cadherin 1	Mus musculus	154-159
3695805-2	1987	The highest values for effective renal plasma flow and glomerular filtration rate were observed after 8 weeks dietary supplementation with omega-3 PUFA"s without a relationship with baseline values.	omega-3	139-146	pumilio RNA binding family member 3	Homo sapiens	147-151
3520252-2	1986	One such group may have a mutant delta-6-desaturase which prefers the omega-6-series essential fatty acids over the omega-3 series essential fatty acids resulting in low cis-linoleic acid blood levels.	omega-3	116-123	fatty acid desaturase 2	Homo sapiens	33-51
34046766-9	2021	Combined supplementation with B12 and omega-3 improved the cerebellar histology, increased MBP, and decreased apoptotic and necroptotic markers.	omega-3	38-45	myelin basic protein	Rattus norvegicus	91-94
34037942-11	2022	In conclusion, prophylactic administration of omega-3 and probiotic combination reduced ABL and improved serum IL1beta, IL6, and IL10 levels more than their single use.	omega-3	46-53	interleukin 1 alpha	Rattus norvegicus	111-118
34037942-11	2022	In conclusion, prophylactic administration of omega-3 and probiotic combination reduced ABL and improved serum IL1beta, IL6, and IL10 levels more than their single use.	omega-3	46-53	interleukin 6	Rattus norvegicus	120-123
34037942-11	2022	In conclusion, prophylactic administration of omega-3 and probiotic combination reduced ABL and improved serum IL1beta, IL6, and IL10 levels more than their single use.	omega-3	46-53	interleukin 10	Rattus norvegicus	129-133
33573088-6	2021	We found that: (a) countries whose source of omega-3 is from marine origin have lower fatality rates; and (b) like linoleic acid, omega-3 PUFA could also bind to the closed conformation of spike protein and therefore, could help reduce COVID-19 complications by reducing viral entrance to cells, in addition to their known anti-inflammatory effects.	omega-3	45-52	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	189-194
33503568-3	2021	Omega-3 and omega-6 fatty acids can be converted into bioactive epoxides by cytochrome P450s (CYP450), which play pro-resolving roles in the inflammatory response; however, soluble epoxide hydrolase (sEH) metabolizes epoxides into diols, which lack pro-resolving functions and can be cytotoxic.	omega-3	0-7	epoxide hydrolase 2	Homo sapiens	173-198
33503568-3	2021	Omega-3 and omega-6 fatty acids can be converted into bioactive epoxides by cytochrome P450s (CYP450), which play pro-resolving roles in the inflammatory response; however, soluble epoxide hydrolase (sEH) metabolizes epoxides into diols, which lack pro-resolving functions and can be cytotoxic.	omega-3	0-7	epoxide hydrolase 2	Homo sapiens	200-203
33618966-10	2021	CONCLUSIONS: This study suggests that omega-3 PUFAs are effect modifiers for VO2max and CRP and that the anti-inflammatory benefits of increasing cardiovascular fitness are associated with omega-3 PUFAs.	omega-3	38-45	C-reactive protein	Homo sapiens	88-91
33573088-6	2021	We found that: (a) countries whose source of omega-3 is from marine origin have lower fatality rates; and (b) like linoleic acid, omega-3 PUFA could also bind to the closed conformation of spike protein and therefore, could help reduce COVID-19 complications by reducing viral entrance to cells, in addition to their known anti-inflammatory effects.	omega-3	130-137	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	189-194
32122630-1	2020	This study evaluated the effect of systemic administration of omega-3 on the expression of interleukins IL-1beta and IL-10 and tumour necrosis factor alpha (TNF-alpha) and on the thickness of cartilage in the temporomandibular joint (TMJ) inflammatory model induced by complete Freund"s adjuvant (CFA).	omega-3	62-69	interleukin 1 alpha	Rattus norvegicus	104-112
33480268-3	2021	It included experimental studies that investigated the effects of omega-3 supplementation for diabetes treatment or prevention and its relationship with fasting blood glucose, insulin resistance, and glycated hemoglobin.	omega-3	66-73	insulin	Homo sapiens	176-183
33480268-6	2021	A meta-analysis was carried out to evaluate the effect of omega-3 on fasting blood glucose, insulin resistance, and glycated hemoglobin.	omega-3	58-65	insulin	Homo sapiens	92-99
33094384-1	2020	Delta6 fatty acid desaturases (FADS6) have different substrate specificities that impact the ratio of omega-6/omega-3 polyunsaturated fatty acids, which are involved in regulating multiple signalling pathways associated with various diseases.	omega-3	110-117	fatty acid desaturase 6	Homo sapiens	31-36
30961460-9	2020	Co-supplementation of omega-3 and vitamin E significantly increased total antioxidant capacity (mg/dl) (1.15 +- 0.93 vs -0.6 +- 0.72; P < 0.001), catalase activity (IU/L) (1.19 +- 1.06 vs 0.12 +- 0.36; P < 0.001) and glutathione levels (mumol/L) (1.5 +- 1.06 vs 0.23 +- 1.43; P = 0.028).	omega-3	22-29	catalase	Homo sapiens	146-154
30961460-11	2020	Conclusion: Co-supplementation with omega-3 and vitamin E had beneficial effect on total antioxidant capacity, malondialdehyde concentrations, glutathione levels and catalase activity.	omega-3	36-43	catalase	Homo sapiens	166-174
33396616-0	2020	High Maternal Omega-3 Supplementation Dysregulates Body Weight and Leptin in Newborn Male and Female Rats: Implications for Hypothalamic Developmental Programming.	omega-3	14-21	leptin	Rattus norvegicus	67-73
33343231-10	2020	Conclusions: Saturated fatty acids and omega-3 and omega-9 erucic acids can affect signaling in the BDNF synthesis resulting in the decrease in BDNF.	omega-3	39-46	brain derived neurotrophic factor	Homo sapiens	100-104
33343231-10	2020	Conclusions: Saturated fatty acids and omega-3 and omega-9 erucic acids can affect signaling in the BDNF synthesis resulting in the decrease in BDNF.	omega-3	39-46	brain derived neurotrophic factor	Homo sapiens	144-148
32122630-1	2020	This study evaluated the effect of systemic administration of omega-3 on the expression of interleukins IL-1beta and IL-10 and tumour necrosis factor alpha (TNF-alpha) and on the thickness of cartilage in the temporomandibular joint (TMJ) inflammatory model induced by complete Freund"s adjuvant (CFA).	omega-3	62-69	interleukin 10	Rattus norvegicus	117-122
32122630-1	2020	This study evaluated the effect of systemic administration of omega-3 on the expression of interleukins IL-1beta and IL-10 and tumour necrosis factor alpha (TNF-alpha) and on the thickness of cartilage in the temporomandibular joint (TMJ) inflammatory model induced by complete Freund"s adjuvant (CFA).	omega-3	62-69	tumor necrosis factor	Rattus norvegicus	157-166
32122630-5	2020	IL-1beta levels (median; interquartile range) were higher (P<0.0001) in the CFA group (46.4 ng/ml; 39.4-53.3) than in the control group (1.81 ng/ml; 1.5-5.4), but there were no differences between the control, omega-3, and dexamethasone groups.	omega-3	210-217	interleukin 1 alpha	Rattus norvegicus	0-8
32652034-0	2020	A Low omega-6 to omega-3 PUFA Ratio (n-6:n-3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth.	omega-3	17-24	pumilio RNA binding family member 3	Homo sapiens	25-29
32652034-0	2020	A Low omega-6 to omega-3 PUFA Ratio (n-6:n-3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth.	omega-3	17-24	pumilio RNA binding family member 3	Homo sapiens	45-49
32652034-1	2020	BACKGROUND: Recent literature suggests that the Western diet"s imbalance between high omega-6 (n-6) and low omega-3 (n-3) PUFA intake contributes to fatty liver disease in obese youth.	omega-3	108-115	pumilio RNA binding family member 3	Homo sapiens	122-126
32580481-7	2020	Importantly, the highly pro-arrhythmic ISO-induced disordered cardiomyocyte distribution of electrical coupling protein, connexin-43 (Cx43), and its remodeling (lateralization) were significantly attenuated by melatonin and omega-3 in Wistar as well as SHR hearts.	omega-3	224-231	gap junction protein, alpha 1	Rattus norvegicus	121-132
32454411-2	2020	Here, we report the effects of higher endogenous omega-3 PUFA on memory impairment in the hippocampus by studying mice with transgenic expression of the fat-1 gene that converts omega-6 to omega-3 PUFA.	omega-3	49-56	FAT atypical cadherin 1	Mus musculus	153-158
32454411-2	2020	Here, we report the effects of higher endogenous omega-3 PUFA on memory impairment in the hippocampus by studying mice with transgenic expression of the fat-1 gene that converts omega-6 to omega-3 PUFA.	omega-3	189-196	FAT atypical cadherin 1	Mus musculus	153-158
32580481-0	2020	Antiarrhythmic Effects of Melatonin and Omega-3 Are Linked with Protection of Myocardial Cx43 Topology and Suppression of Fibrosis in Catecholamine Stressed Normotensive and Hypertensive Rats.	omega-3	40-47	gap junction protein, alpha 1	Rattus norvegicus	89-93
32681642-12	2020	Sows fed LPL had increased (P < 0.05) omega-6:omega-3 (22.1 vs. 23.7) and unsaturated:saturated (1.4 vs. 1.6) fatty acids ratios with increased oleic acid (29.1 vs. 31.4%) and tended to have increased (P = 0.092) IgG (1.14 vs. 1.94 g/L) and linoleic acid (17.7 vs. 18.7%) in the milk on d 18 of lactation.	omega-3	46-53	lipoprotein lipase	Homo sapiens	9-12
32765412-2	2020	Omega-3 polysaturated fatty acids (Omega-3, PUFAs) are involved in the clearance of amyloid-ss through the glymphatic system and this effect is Aquaporin-4 (AQP4) dependent.	omega-3	0-7	aquaporin 4	Mus musculus	144-155
32765412-2	2020	Omega-3 polysaturated fatty acids (Omega-3, PUFAs) are involved in the clearance of amyloid-ss through the glymphatic system and this effect is Aquaporin-4 (AQP4) dependent.	omega-3	0-7	aquaporin 4	Mus musculus	157-161
32580481-7	2020	Importantly, the highly pro-arrhythmic ISO-induced disordered cardiomyocyte distribution of electrical coupling protein, connexin-43 (Cx43), and its remodeling (lateralization) were significantly attenuated by melatonin and omega-3 in Wistar as well as SHR hearts.	omega-3	224-231	gap junction protein, alpha 1	Rattus norvegicus	134-138
32580481-10	2020	Altogether, the results indicate that anti-arrhythmic effects of melatonin and omega-3 might be attributed to the protection of myocardial Cx43 topology and suppression of fibrosis in the setting of oxidative stress induced by catecholamine overdrive in normotensive and hypertensive rats.	omega-3	79-86	gap junction protein, alpha 1	Rattus norvegicus	139-143
32398692-0	2020	Aryl Hydrocarbon Receptor-Dependent inductions of omega-3 and omega-6 polyunsaturated fatty acid metabolism act inversely on tumor progression.	omega-3	50-57	aryl-hydrocarbon receptor	Mus musculus	0-25
32563240-15	2020	The association between total omega-3 PUFA and EC recurrence tended to be stronger among patients with deeper myometrial invasion (OR = 3.41; 95%CI = 1.06-10.95; P-interaction = 0.04).	omega-3	30-37	pumilio RNA binding family member 3	Homo sapiens	38-42
32545637-2	2020	sEH rapidly degrades cytochrome P450-produced epoxygenated lipids (epoxy-fatty acids), which are synthesized from omega-3 and omega-6 polyunsaturated fatty acids, that generally exert beneficial effects on several cellular processes.	omega-3	114-121	epoxide hydrolase 2	Homo sapiens	0-3
32179408-0	2020	High ratio of omega-3/omega-6 polyunsaturated fatty acids targets mTORC1 to prevent high-fat diet-induced metabolic syndrome and mitochondrial dysfunction in mice.	omega-3	14-21	CREB regulated transcription coactivator 1	Mus musculus	66-72
32435279-9	2020	Conclusion: Vitamin D and omega-3 co-supplementation improved fasting serum glucose, insulin, high-density lipoprotein-cholesterol level, homeostasis model assessment-beta cell function, weight and waist circumference in women of reproductive age with prediabetes and hypovitaminosis D. This co-supplementation can therefore be recommended for glycemic control in these women.Trial registration Iranian Registry of Clinical Trials Code: IRCT20100130003226N17.	omega-3	26-33	insulin	Homo sapiens	85-92
31010701-2	2020	The aim of this study was to systematically evaluate and summarize available evidence on the association between omega-3 and omega-6 PUFA levels and risk of metabolic syndrome (MetS).	omega-3	113-120	pumilio RNA binding family member 3	Homo sapiens	133-137
31830469-0	2020	Intake of omega-3 formulation EPA:DHA 6:1 by old rats for 2 weeks improved endothelium-dependent relaxations and normalized the expression level of ACE/AT1R/NADPH oxidase and the formation of ROS in the mesenteric artery.	omega-3	10-17	angiotensin I converting enzyme	Rattus norvegicus	148-151
31830469-0	2020	Intake of omega-3 formulation EPA:DHA 6:1 by old rats for 2 weeks improved endothelium-dependent relaxations and normalized the expression level of ACE/AT1R/NADPH oxidase and the formation of ROS in the mesenteric artery.	omega-3	10-17	angiotensin II receptor, type 1a	Rattus norvegicus	152-156
32185236-8	2020	Compared with placebo, omega-3, magnesium, vitamin D, zinc, and probiotics were more beneficial for improving FPG, serum insulin, and HOMA-IR.	omega-3	23-30	insulin	Homo sapiens	121-128
31489674-9	2019	The hypolipidemic and hepatoprotective effects of chia may be correlated to its high content of alpha-linolenic acid (omega-3) and phenolics.	omega-3	118-125	chitinase acidic	Homo sapiens	50-54
31415816-0	2019	Why DREAM should make you think twice about recommending Omega-3 supplements.	omega-3	57-64	potassium voltage-gated channel interacting protein 3	Homo sapiens	4-9
30541065-3	2019	Angiotensin receptor blockers and omega-3 polyunsaturated fatty acids (omega-3) may reduce IL-6 and may potentially improve physical function.	omega-3	34-41	interleukin 6	Homo sapiens	91-95
32161487-6	2020	Most of the clinical trials that were conducted on their therapeutic benefits in IgAN patients reported positive outcomes with low and high doses of omega-3 PUFAs.	omega-3	149-156	IGAN1	Homo sapiens	81-85
29741967-6	2019	Structural injury was observed in mothers and their pups as Bowman"s capsule and tubular dilatation and increased expression of PCNA that were decreased following omega-3 supplementation added to down regulation of Wnt4, Pax2 gene and podocin expression.	omega-3	163-170	proliferating cell nuclear antigen	Rattus norvegicus	128-132
29741967-6	2019	Structural injury was observed in mothers and their pups as Bowman"s capsule and tubular dilatation and increased expression of PCNA that were decreased following omega-3 supplementation added to down regulation of Wnt4, Pax2 gene and podocin expression.	omega-3	163-170	Wnt family member 4	Rattus norvegicus	215-219
29741967-6	2019	Structural injury was observed in mothers and their pups as Bowman"s capsule and tubular dilatation and increased expression of PCNA that were decreased following omega-3 supplementation added to down regulation of Wnt4, Pax2 gene and podocin expression.	omega-3	163-170	paired box 2	Rattus norvegicus	221-225
29741967-6	2019	Structural injury was observed in mothers and their pups as Bowman"s capsule and tubular dilatation and increased expression of PCNA that were decreased following omega-3 supplementation added to down regulation of Wnt4, Pax2 gene and podocin expression.	omega-3	163-170	NPHS2 stomatin family member, podocin	Rattus norvegicus	235-242
31398226-2	2019	Diets enriched in omega-6 and deficient in omega-3 PUFAs (low dietary omega-3/omega-6 PUFA ratio), have been associated with the promotion of pathogenesis of diseases in humans and other mammals.	omega-3	43-50	pumilio RNA-binding family member 3	Danio rerio	51-55
31216727-8	2019	Milk from G cows was richer in saturated fatty acids, likely because of the contribution of palmitic acid present in the grazed barley grass, and also showed higher contents of some healthy fatty acids, such as rumenic acid and alpha-linolenic acid, and a lower omega-6/omega-3 ratio.	omega-3	270-277	Weaning weight-maternal milk	Bos taurus	0-4
30578965-5	2019	Free fatty acid receptor 4 (FFAR4) is expressed in bone cells and preferentially binds omega-3 and omega-7 UFAs.	omega-3	87-94	free fatty acid receptor 4	Mus musculus	28-33
30984926-5	2019	The results indicated that the CYP51 expression was up-regulated in granulosa cells by omega-3.	omega-3	87-94	cytochrome P450, family 51	Rattus norvegicus	31-36
30984926-8	2019	Furthermore, the PI3K/Akt pathway was required for the regulation of CYP51 expression, steroidogenesis and cell development by omega-3 in PCOS granulosa cells.	omega-3	127-134	AKT serine/threonine kinase 1	Rattus norvegicus	22-25
30984926-8	2019	Furthermore, the PI3K/Akt pathway was required for the regulation of CYP51 expression, steroidogenesis and cell development by omega-3 in PCOS granulosa cells.	omega-3	127-134	cytochrome P450, family 51	Rattus norvegicus	69-74
30984926-9	2019	Our data demonstrate that omega-3 potentiates the cellular development and steroid biosynthesis via CYP51 up-regulation in PCOS, which are mediated through the activation of the PI3K/Akt pathway.	omega-3	26-33	cytochrome P450, family 51	Rattus norvegicus	100-105
30984926-9	2019	Our data demonstrate that omega-3 potentiates the cellular development and steroid biosynthesis via CYP51 up-regulation in PCOS, which are mediated through the activation of the PI3K/Akt pathway.	omega-3	26-33	AKT serine/threonine kinase 1	Rattus norvegicus	183-186
31380258-8	2019	Conclusion: The positive effect of omega-3 on cystatin C levels showed that it may have a protective role in the prevention of CIN in post-PCI patients with normal kidney function.	omega-3	35-42	cystatin C	Homo sapiens	46-56
30368227-7	2019	Fads2-/- mice fed an ALA-enriched diet had reduced body weight, little-to-no omega-3 LC-PUFA and a near complete loss of all omega-3 derived oxylipins in both epididymal and inguinal WAT (P&lt;.05) compared to their WT counterparts, as well as altered expression of key regulators of the fatty acid desaturase pathway.	omega-3	77-84	fatty acid desaturase 2	Mus musculus	0-5
30813440-2	2019	Omega-3 polyunsaturated fatty acid (PUFA) supplementation is recommended for prevention of chronic disease, and is thought to reduce raised liver fat, yet there have been few randomized controlled trials with accurate measurement of liver fat.	omega-3	0-7	FAT atypical cadherin 1	Homo sapiens	24-27
30813440-2	2019	Omega-3 polyunsaturated fatty acid (PUFA) supplementation is recommended for prevention of chronic disease, and is thought to reduce raised liver fat, yet there have been few randomized controlled trials with accurate measurement of liver fat.	omega-3	0-7	FAT atypical cadherin 1	Homo sapiens	146-149
30338745-11	2019	CONCLUSION: The anticancer effect of omega-3 PUFAs was positively correlated with global 5hmC accumulation and TET1 expression, suggesting DNA hydroxymethylation pathway was factually involved in the anticancer process of omega-3 PUFAs.	omega-3	37-44	tet methylcytosine dioxygenase 1	Rattus norvegicus	111-115
31096898-6	2019	However, omega-3 significantly reduced TNF-alpha concentration (WMD: -16.76; 95% CI: -18.63 to -14.88; P < 0.00001) compared to placebo.	omega-3	9-16	tumor necrosis factor	Homo sapiens	39-48
30558276-1	2018	The enhancement of health-beneficial omega-3 long-chain (&gt;=C20) polyunsaturated fatty acid (n-3 LC-PUFA) contents in the muscle, liver, heart, and kidney of Australian prime lambs through pasture grazing and supplementation with oil infused pellets was investigated.	omega-3	37-44	PUFA	Ovis aries	102-106
30648357-0	2019	Omega-3 multiple effects increasing glucocorticoid-induced muscle atrophy: autophagic, AMPK and UPS mechanisms.	omega-3	0-7	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	87-91
28987470-10	2018	Messenger RNA (mRNA) of the Nuclear Factor kappa beta (NF-kappaB) and its target genes InterLeukin 1 beta (IL-1beta) and IL-6 was downregulated significantly (p < 0.05) in leukocytes from DMD boys supplemented with omega-3 long chain-PUFA for 6 months, compared to the placebo group.	omega-3	215-222	nuclear factor kappa B subunit 1	Homo sapiens	55-64
28987470-10	2018	Messenger RNA (mRNA) of the Nuclear Factor kappa beta (NF-kappaB) and its target genes InterLeukin 1 beta (IL-1beta) and IL-6 was downregulated significantly (p < 0.05) in leukocytes from DMD boys supplemented with omega-3 long chain-PUFA for 6 months, compared to the placebo group.	omega-3	215-222	interleukin 1 beta	Homo sapiens	87-105
28987470-10	2018	Messenger RNA (mRNA) of the Nuclear Factor kappa beta (NF-kappaB) and its target genes InterLeukin 1 beta (IL-1beta) and IL-6 was downregulated significantly (p < 0.05) in leukocytes from DMD boys supplemented with omega-3 long chain-PUFA for 6 months, compared to the placebo group.	omega-3	215-222	interleukin 1 alpha	Homo sapiens	107-115
28987470-10	2018	Messenger RNA (mRNA) of the Nuclear Factor kappa beta (NF-kappaB) and its target genes InterLeukin 1 beta (IL-1beta) and IL-6 was downregulated significantly (p < 0.05) in leukocytes from DMD boys supplemented with omega-3 long chain-PUFA for 6 months, compared to the placebo group.	omega-3	215-222	interleukin 6	Homo sapiens	121-125
30102092-3	2018	METHODS: Randomized placebo-controlled trials investigating the impact of omega-3 on apo C-III levels were searched in PubMed-Medline, SCOPUS, Web of Science and Google Scholar.	omega-3	74-81	apolipoprotein C3	Homo sapiens	85-94
30400671-8	2018	Omega-3 derived epoxymetabolites appeared beneficially associated with BP and vascular structure/function only in obese children with HBP.	omega-3	0-7	high density lipoprotein binding protein	Homo sapiens	134-137
30475967-11	2018	Participants in the nut group showed an increase in the consumption of total fat, monounsaturated fatty acids, polyunsaturated fatty acids, magnesium, vitamin E, alpha-linolenic acid, total omega-3 (n-3) and omega-3:omega-6 ratio intake during the intervention.	omega-3	190-197	NUT midline carcinoma family member 1	Homo sapiens	20-23
30102092-7	2018	RESULTS: This meta-analysis comprising 2062 subjects showed a significant reduction of apo C-III concentrations following treatment with omega-3 (WMD: -22.18 mg/L, 95% confidence interval: -31.61, -12.75, p < .001; I2: 88.24%).	omega-3	137-144	apolipoprotein C3	Homo sapiens	87-96
30102092-10	2018	A positive association between the apo C-III-lowering effect of omega-3 with baseline apo C-III concentrations and treatment duration was found.	omega-3	64-71	apolipoprotein C3	Homo sapiens	35-44
30102092-10	2018	A positive association between the apo C-III-lowering effect of omega-3 with baseline apo C-III concentrations and treatment duration was found.	omega-3	64-71	apolipoprotein C3	Homo sapiens	86-95
30410689-7	2018	Conclusions: Co-supplementation with omega-3 and vitamin E for 12 weeks among patients with PCOS had beneficial effects on CIMT and serum hs-CRP values, but unchanged NO values.	omega-3	37-44	CIMT	Homo sapiens	123-127
30060953-4	2018	Omega-3 significantly decreased EP2 levels on days 3 and 4, while omega-6 caused an increase on days 3-5 of pregnancy.	omega-3	0-7	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	32-35
30074573-13	2018	Because improvement in omega-3 levels has been shown to help pulmonary and inflammatory status as well as anthropometric parameters in CF, RELiZORB may have important long-term therapeutic benefits in patients with CF.	omega-3	23-30	REL proto-oncogene, NF-kB subunit	Homo sapiens	139-147
29567080-0	2018	The Effect of Omega-3 on Circulating Adiponectin in Adults With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.	omega-3	14-21	adiponectin, C1Q and collagen domain containing	Homo sapiens	37-48
29567080-2	2018	The objective of this study was to evaluate the effect of omega-3 (food or supplement) on circulating adiponectin in patients with type 2 diabetes through a systematic review of meta-analyses of randomized controlled trials.	omega-3	58-65	adiponectin, C1Q and collagen domain containing	Homo sapiens	102-113
29567080-8	2018	In subgroup analyses, adiponectin levels increased only in those who had consumed omega-3 for more than 8 weeks.	omega-3	82-89	adiponectin, C1Q and collagen domain containing	Homo sapiens	22-33
29567080-9	2018	This systematic review and meta-analysis of randomized, placebo-controlled clinical trials suggests that omega-3 in patients with type 2 diabetes increases circulating adiponectin.	omega-3	105-112	adiponectin, C1Q and collagen domain containing	Homo sapiens	168-179
29567080-10	2018	These findings support the potentially beneficial effects of dietary omega-3 in patients with type 2 diabetes on pathways related to adiponectin metabolism.	omega-3	69-76	adiponectin, C1Q and collagen domain containing	Homo sapiens	133-144
30276144-0	2018	Impact of Omega-3 Supplementation on High Sensitive C-Reactive Protein Level and 30-Day Major Adverse Cardiac Events After the Implementation of Coronary Stent in Patients with Chronic Kidney Disease: A Randomized Clinical Study.	omega-3	10-17	C-reactive protein	Homo sapiens	52-70
29803716-10	2018	The following compounds showed a significant small to large effect in reducing IL-6 levels: probiotics (-0.68 pg/ml), ARBs (-0.37 pg/ml) and omega-3 (-0.19 pg/ml).	omega-3	141-148	interleukin 6	Homo sapiens	79-83
29803716-11	2018	For CRP, a significant small to medium effect was observed with probiotics (-0.43 mg/L), ARBs (-0.2 mg/L), omega-3 (-0.17 mg/L) and metformin (-0.16 mg/L).	omega-3	107-114	C-reactive protein	Homo sapiens	4-7
29597832-8	2018	PUFA omega-3 supplementation produced a higher level of total omega-3 in lung tissue and breast milk and was found to reverse the reduced levels of VEGFA, VEGF receptor 2, angiopoietin-1 (ANGPT1), endothelial TEK tyrosine kinase, endothelial nitric oxide synthase, and nitric oxide concentrations in lung tissue and the increased ANGPT2 levels in hyperoxia-exposed rats.	omega-3	5-12	pumilio RNA binding family member 3	Homo sapiens	0-4
29597832-8	2018	PUFA omega-3 supplementation produced a higher level of total omega-3 in lung tissue and breast milk and was found to reverse the reduced levels of VEGFA, VEGF receptor 2, angiopoietin-1 (ANGPT1), endothelial TEK tyrosine kinase, endothelial nitric oxide synthase, and nitric oxide concentrations in lung tissue and the increased ANGPT2 levels in hyperoxia-exposed rats.	omega-3	5-12	vascular endothelial growth factor A	Rattus norvegicus	148-153
29597832-8	2018	PUFA omega-3 supplementation produced a higher level of total omega-3 in lung tissue and breast milk and was found to reverse the reduced levels of VEGFA, VEGF receptor 2, angiopoietin-1 (ANGPT1), endothelial TEK tyrosine kinase, endothelial nitric oxide synthase, and nitric oxide concentrations in lung tissue and the increased ANGPT2 levels in hyperoxia-exposed rats.	omega-3	5-12	angiopoietin 1	Rattus norvegicus	172-186
29597832-8	2018	PUFA omega-3 supplementation produced a higher level of total omega-3 in lung tissue and breast milk and was found to reverse the reduced levels of VEGFA, VEGF receptor 2, angiopoietin-1 (ANGPT1), endothelial TEK tyrosine kinase, endothelial nitric oxide synthase, and nitric oxide concentrations in lung tissue and the increased ANGPT2 levels in hyperoxia-exposed rats.	omega-3	5-12	angiopoietin 1	Rattus norvegicus	188-194
29597832-8	2018	PUFA omega-3 supplementation produced a higher level of total omega-3 in lung tissue and breast milk and was found to reverse the reduced levels of VEGFA, VEGF receptor 2, angiopoietin-1 (ANGPT1), endothelial TEK tyrosine kinase, endothelial nitric oxide synthase, and nitric oxide concentrations in lung tissue and the increased ANGPT2 levels in hyperoxia-exposed rats.	omega-3	5-12	angiopoietin 2	Rattus norvegicus	330-336
29276972-9	2018	Deflazacort and omega-3 reduced the plasma levels of the pro-inflammatory (TNF-alpha, INF-gamma, IL-6) and pro-fibrotic (IL-13 and TGF-beta) interleukins and increased the plasma levels of IL-10.	omega-3	16-23	tumor necrosis factor	Mus musculus	75-84
29175142-0	2018	Flaxseed oil rich in omega-3 protects aorta against inflammation and endoplasmic reticulum stress partially mediated by GPR120 receptor in obese, diabetic and dyslipidemic mice models.	omega-3	21-28	free fatty acid receptor 4	Mus musculus	120-126
29784972-3	2018	We performed genome-wide screening of mouse cytochrome P450 (CYP) isoforms to explore enzymes involved in omega-3 oxygenation of EPA.	omega-3	106-113	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	44-59
29784972-3	2018	We performed genome-wide screening of mouse cytochrome P450 (CYP) isoforms to explore enzymes involved in omega-3 oxygenation of EPA.	omega-3	106-113	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	61-64
29642372-0	2018	omega-3 and omega-6 Fatty Acids Modulate Conventional and Atypical Protein Kinase C Activities in a Brain Fatty Acid Binding Protein Dependent Manner in Glioblastoma Multiforme.	omega-3	0-7	fatty acid binding protein 7	Homo sapiens	100-132
29676540-6	2018	Omega-3 supplementation increased levels of adiponectin (0.48 mug/mL; 95% confidence interval [CI], 0.27 to 0.68; P&lt;0.00001, n=10 trials), but effects disappeared after sensitivity analysis.	omega-3	0-7	adiponectin, C1Q and collagen domain containing	Homo sapiens	44-55
29998870-8	2018	In women, TNF-alpha had a significant positive association with total omega-3 (P &lt;0.05) and omega-6 (P &lt;0.01) PUFAs, IL-6 had a significant (P &lt;0.05) positive association with total monounsaturated fatty acids and MCP-1 had a significant positive association with total trans-fatty acids (P &lt;0.05).	omega-3	70-77	tumor necrosis factor	Homo sapiens	10-19
29235036-1	2018	The omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA) is enriched in neural membranes of the CNS, and recent studies have shown a role of DHA metabolism by 15-lipoxygenase-1 (Alox15) in prefrontal cortex resolvin D1 formation, hippocampo-prefrontal cortical long-term-potentiation, spatial working memory, and anti-nociception/anxiety.	omega-3	4-11	arachidonate 15-lipoxygenase	Homo sapiens	188-194
29381560-0	2018	Omega-3 decreases IL-6 levels in HIV and human herpesvirus-8 coinfected patients in Uganda.	omega-3	0-7	interleukin 6	Homo sapiens	18-22
29381560-9	2018	Inflammatory cytokine IL-6 concentrations decreased in omega-3 participants (-0.78 pg/ml) but increased in placebo participants (+3.2 pg/ml; P = 0.04).	omega-3	55-62	interleukin 6	Homo sapiens	22-26
29381560-10	2018	We observed a trend toward decreased IL-6 after omega-3 supplementation specific to Kaposi sarcoma patients (P = 0.08).	omega-3	48-55	interleukin 6	Homo sapiens	37-41
29381560-12	2018	CONCLUSION: Omega-3 supplementation decreased IL-6 concentrations among HIV and HHV-8 coinfected Ugandans, which may have clinical benefit for Kaposi sarcoma patients.	omega-3	12-19	interleukin 6	Homo sapiens	46-50
29276972-9	2018	Deflazacort and omega-3 reduced the plasma levels of the pro-inflammatory (TNF-alpha, INF-gamma, IL-6) and pro-fibrotic (IL-13 and TGF-beta) interleukins and increased the plasma levels of IL-10.	omega-3	16-23	interleukin 6	Mus musculus	97-101
29276972-9	2018	Deflazacort and omega-3 reduced the plasma levels of the pro-inflammatory (TNF-alpha, INF-gamma, IL-6) and pro-fibrotic (IL-13 and TGF-beta) interleukins and increased the plasma levels of IL-10.	omega-3	16-23	interleukin 13	Mus musculus	121-126
29276972-9	2018	Deflazacort and omega-3 reduced the plasma levels of the pro-inflammatory (TNF-alpha, INF-gamma, IL-6) and pro-fibrotic (IL-13 and TGF-beta) interleukins and increased the plasma levels of IL-10.	omega-3	16-23	transforming growth factor, beta 1	Mus musculus	131-139
29276972-9	2018	Deflazacort and omega-3 reduced the plasma levels of the pro-inflammatory (TNF-alpha, INF-gamma, IL-6) and pro-fibrotic (IL-13 and TGF-beta) interleukins and increased the plasma levels of IL-10.	omega-3	16-23	interleukin 10	Mus musculus	189-194
30114709-8	2018	In addition, Rp-induced hypertriglyceridemia and hypercholesterolemia were completely abolished by omega-3 PUFA supplementation.	omega-3	99-106	pumilio RNA binding family member 3	Homo sapiens	107-111
29385062-6	2018	Results of RT-PCR indicated that omega-3 supplementation upregulated gene expression of peroxisome proliferator-activated receptor gamma (PPAR-gamma) (P = 0.04) in PBMCs of patients with GDM, compared with the placebo.	omega-3	33-40	peroxisome proliferator activated receptor gamma	Homo sapiens	88-136
29385062-6	2018	Results of RT-PCR indicated that omega-3 supplementation upregulated gene expression of peroxisome proliferator-activated receptor gamma (PPAR-gamma) (P = 0.04) in PBMCs of patients with GDM, compared with the placebo.	omega-3	33-40	peroxisome proliferator activated receptor gamma	Homo sapiens	138-148
28986132-3	2018	Inflammation resolution is an active process controlled by lipidic specialized pro-resolving mediators (SPMs), derived from omega-3 or omega-6 essential polyunsaturated fatty acids (PUFA) through the activity of lipoxygenases (ALOX5 and 15).	omega-3	124-131	arachidonate 5-lipoxygenase	Homo sapiens	227-232
28798154-0	2017	A novel synthetic analogue of omega-3 17,18-epoxyeicosatetraenoic acid activates TNF receptor-1/ASK1/JNK signaling to promote apoptosis in human breast cancer cells.	omega-3	30-37	tumor necrosis factor	Homo sapiens	81-84
28798154-0	2017	A novel synthetic analogue of omega-3 17,18-epoxyeicosatetraenoic acid activates TNF receptor-1/ASK1/JNK signaling to promote apoptosis in human breast cancer cells.	omega-3	30-37	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	96-100
28798154-0	2017	A novel synthetic analogue of omega-3 17,18-epoxyeicosatetraenoic acid activates TNF receptor-1/ASK1/JNK signaling to promote apoptosis in human breast cancer cells.	omega-3	30-37	mitogen-activated protein kinase 8	Homo sapiens	101-104
28835852-1	2017	BACKGROUND: Omega-3 long-chain (&gt;=C20) polyunsaturated fatty acids (omega3 LC-PUFA) confer important attributes to health-conscious meat consumers due to the significant role they play in brain development, prevention of coronary heart disease, obesity and hypertension.	omega-3	12-19	PUFA	Ovis aries	81-85
29084142-2	2017	The purpose of this updated review is to focus on the novel cellular and molecular effects of omega-3 PUFAs, in the context of the mechanisms and factors involved in the development of cardiac arrhythmias; to provide results of the most recent studies on the omega-3 PUFA anti-arrhythmic efficacy and to discuss the lack of the benefit in relation to omega-3 PUFA status.	omega-3	94-101	pumilio RNA binding family member 3	Homo sapiens	102-106
28623422-6	2017	In the present study, we test our hypothesis that omega-3 affects MMP-9 and thereby benefits muscle regeneration and myoblast transplantation in the mdx mouse.	omega-3	50-57	matrix metallopeptidase 9	Mus musculus	66-71
28623422-7	2017	We observe that omega-3 reduces MMP-9 gene expression and improves myoblast engraftment, satellite cell activation, and muscle regeneration by mechanisms involving, at least in part, the regulation of macrophages, as shown here with the fluorescence-activated cell sorting technique.	omega-3	16-23	matrix metallopeptidase 9	Mus musculus	32-37
28688796-7	2017	Both apoE3 and apoE4 increased saturated and monounsaturated fatty acids (SFA and MUFA), omega-6/omega-3 ratio and decreased total polyunsaturated fatty acid (PUFA) amount, but with various intensities.	omega-3	97-104	apolipoprotein E	Homo sapiens	5-10
28688796-7	2017	Both apoE3 and apoE4 increased saturated and monounsaturated fatty acids (SFA and MUFA), omega-6/omega-3 ratio and decreased total polyunsaturated fatty acid (PUFA) amount, but with various intensities.	omega-3	97-104	apolipoprotein E	Homo sapiens	15-20
28974016-2	2017	Fat-1 transgenic mice produce omega3-Polyunsaturated fatty acids (omega3-PUFAs) from omega6-Polyunsaturated fatty acids (omega6-PUFAs) without a dietary omega3-PUFAs supplement, leading to a high accumulation of omega-3 in various tissues.	omega-3	212-219	FAT atypical cadherin 1	Mus musculus	0-5
28817082-1	2017	The objective of the study was to ascertain whether human health beneficial omega-3 long-chain (&gt;=C20) polyunsaturated fatty acid (n-3 LC-PUFA) content in heart, kidney and liver can be enhanced by supplementing prime lambs with graded levels of canola and flaxseed oil.	omega-3	76-83	pumilio RNA binding family member 3	Homo sapiens	141-145
28646265-0	2017	Omega-3 and Omega-6 Fatty Acids Act as Inhibitors of the Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 Activity.	omega-3	0-7	matrix metallopeptidase 2	Homo sapiens	57-83
29072171-9	2017	Omega-3 also significantly decreased total calcium and TRPC1 levels in cardiac and DIA muscles and increased the levels of calsequestrin (cardiac and skeletal) and decreased the oxidative stress marker 4-HNE.	omega-3	0-7	transient receptor potential cation channel, subfamily C, member 1	Mus musculus	55-60
28646265-0	2017	Omega-3 and Omega-6 Fatty Acids Act as Inhibitors of the Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 Activity.	omega-3	0-7	matrix metallopeptidase 9	Homo sapiens	88-114
28646265-2	2017	The recent finding that omega-3 and omega-6 fatty acids exert an anti-inflammatory effect in periodontal diseases has stimulated the present study, designed to determine whether such properties derive from a direct inhibitory action of these compounds on the activity of MMPs.	omega-3	24-31	matrix metallopeptidase 2	Homo sapiens	271-275
28646265-3	2017	To this issue, we investigated the effect exerted by omega-3 and omega-6 fatty acids on the activity of MMP-2 and MMP-9, two enzymes that actively participate to the destruction of the organic matrix of dentin following demineralization operated by bacteria acids.	omega-3	53-60	matrix metallopeptidase 2	Homo sapiens	104-109
28646265-3	2017	To this issue, we investigated the effect exerted by omega-3 and omega-6 fatty acids on the activity of MMP-2 and MMP-9, two enzymes that actively participate to the destruction of the organic matrix of dentin following demineralization operated by bacteria acids.	omega-3	53-60	matrix metallopeptidase 9	Homo sapiens	114-119
28646265-4	2017	Data obtained (both in vitro and on ex-vivo teeth) reveal that omega-3 and omega-6 fatty acids inhibit the proteolytic activity of MMP-2 and MMP-9, two enzymes present in dentin.	omega-3	63-70	matrix metallopeptidase 2	Homo sapiens	131-136
28646265-4	2017	Data obtained (both in vitro and on ex-vivo teeth) reveal that omega-3 and omega-6 fatty acids inhibit the proteolytic activity of MMP-2 and MMP-9, two enzymes present in dentin.	omega-3	63-70	matrix metallopeptidase 9	Homo sapiens	141-146
28665359-3	2017	In this study, we detected that ELOVL5, which plays a key role in the biosynthesis of omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFA), was highly expressed in the liver of laying hens and increased rapidly after sexual maturity.	omega-3	86-93	ELOVL fatty acid elongase 5	Gallus gallus	32-38
28738820-0	2017	Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-induced inflammation by inhibiting the HMGB1/TLR4/NF-kappaB pathway following experimental traumatic brain injury.	omega-3	0-7	high mobility group box 1	Rattus norvegicus	112-117
28738820-0	2017	Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-induced inflammation by inhibiting the HMGB1/TLR4/NF-kappaB pathway following experimental traumatic brain injury.	omega-3	0-7	toll-like receptor 4	Rattus norvegicus	118-122
28570125-2	2017	However, fat-1 transgenic mice can synthesize omega-3 PUFAs from omega-6 PUFAs without dietary supplementation of omega-3, leading to abundant omega-3 PUFA accumulation in various tissues.	omega-3	46-53	FAT atypical cadherin 1	Mus musculus	9-14
28592877-2	2017	In this study, we found that combination of omega-3 free fatty acids (omega-3 FFAs) and ATRA exhibited synergistic inhibition of cell growth in three subtypes (ER+ MCF7, HER2+ SK-BR-3, Triple negative HCC1806 and MDA-MB-231 cells) of human breast cancer cell lines.	omega-3	44-51	erb-b2 receptor tyrosine kinase 2	Homo sapiens	170-174
28570125-2	2017	However, fat-1 transgenic mice can synthesize omega-3 PUFAs from omega-6 PUFAs without dietary supplementation of omega-3, leading to abundant omega-3 PUFA accumulation in various tissues.	omega-3	114-121	FAT atypical cadherin 1	Mus musculus	9-14
28359359-8	2017	The increase of 1 g/1000 kcal in PUFAs, omega-3, and omega-6 reduces, on average, 6%, 48%, and 8% respectively, the mean concentration of IL-1 beta.	omega-3	40-47	interleukin 1 beta	Homo sapiens	138-147
28359359-10	2017	Additional studies on omega-3 and omega-6 intake in relation to inflammatory biomarkers in patients in secondary prevention of CVD are needed, particularly regarding dietary patterns that are rich in some sources of PUFA.	omega-3	22-29	pumilio RNA binding family member 3	Homo sapiens	216-220