PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
10995790-6	2000	The suppression of CCR2 expression by OxLDL was mediated by lipid components of OxLDL, such as the oxidized linoleic acid metabolites 9-HODE and 13-HODE, known activators of PPARgamma.	9-hydroxy-10,12-octadecadienoic acid	134-140	C-C motif chemokine receptor 2	Homo sapiens	19-23
18812596-4	2009	Furthermore, concentrations of the hydroxylated linoleates 9-hydroxy ocatadecadienoic acid (9-HODE) and 13-HODE were elevated by LpL lipolysis, more than other measured oxylipids.	9-hydroxy-10,12-octadecadienoic acid	92-98	lipoprotein lipase	Homo sapiens	129-132
15522842-0	2004	9HODE stimulates cell proliferation and extracellular matrix synthesis in human mesangial cells via PPARgamma.	9-hydroxy-10,12-octadecadienoic acid	0-5	peroxisome proliferator activated receptor gamma	Homo sapiens	100-109
15522842-14	2004	PPARgamma expression induced by 9HODE was also reduced by PD98059 pretreatment.	9-hydroxy-10,12-octadecadienoic acid	32-37	peroxisome proliferator activated receptor gamma	Homo sapiens	0-9
11889173-8	2002	We concluded that 9-HODE, 13-HODE, and 15-HETE activate PPAR gamma in primary human trophoblasts.	9-hydroxy-10,12-octadecadienoic acid	18-24	peroxisome proliferator activated receptor gamma	Homo sapiens	56-66
11304473-15	2001	In addition, VEGF production by THP-1 cells was significantly increased by exposure to 9-HODE and 13-HODE.	9-hydroxy-10,12-octadecadienoic acid	87-93	vascular endothelial growth factor A	Homo sapiens	13-17
11304473-15	2001	In addition, VEGF production by THP-1 cells was significantly increased by exposure to 9-HODE and 13-HODE.	9-hydroxy-10,12-octadecadienoic acid	87-93	GLI family zinc finger 2	Homo sapiens	32-37
16508139-7	2006	When tested the effect of FK614 on CBP recruitment induced by 9(S)-hydroxyoctadecadienoic acid, an endogenous ligand, FK614 negatively modulated PPARgamma activation.	9-hydroxy-10,12-octadecadienoic acid	62-94	CREB binding protein	Homo sapiens	35-38
16508139-7	2006	When tested the effect of FK614 on CBP recruitment induced by 9(S)-hydroxyoctadecadienoic acid, an endogenous ligand, FK614 negatively modulated PPARgamma activation.	9-hydroxy-10,12-octadecadienoic acid	62-94	peroxisome proliferator activated receptor gamma	Homo sapiens	145-154
15381085-5	2004	The induction was reproduced by the lipid components in oxLDL such as 9-HODE and 13-HODE, which are known to activate the peroxisome proliferator-activated receptor gamma (PPARgamma).	9-hydroxy-10,12-octadecadienoic acid	70-76	peroxisome proliferator activated receptor gamma	Homo sapiens	122-170
15381085-5	2004	The induction was reproduced by the lipid components in oxLDL such as 9-HODE and 13-HODE, which are known to activate the peroxisome proliferator-activated receptor gamma (PPARgamma).	9-hydroxy-10,12-octadecadienoic acid	70-76	peroxisome proliferator activated receptor gamma	Homo sapiens	172-181
12921977-8	2003	Furthermore, the PPARgamma agonists 9-hydroxy-(S)-10,12-octadecadienoic acid (9-HODE) and darglitazone also decreased VEGFR-1 mRNA expression.	9-hydroxy-10,12-octadecadienoic acid	78-84	peroxisome proliferator activated receptor gamma	Homo sapiens	17-26
12921977-8	2003	Furthermore, the PPARgamma agonists 9-hydroxy-(S)-10,12-octadecadienoic acid (9-HODE) and darglitazone also decreased VEGFR-1 mRNA expression.	9-hydroxy-10,12-octadecadienoic acid	78-84	fms related receptor tyrosine kinase 1	Homo sapiens	118-125
10995790-6	2000	The suppression of CCR2 expression by OxLDL was mediated by lipid components of OxLDL, such as the oxidized linoleic acid metabolites 9-HODE and 13-HODE, known activators of PPARgamma.	9-hydroxy-10,12-octadecadienoic acid	134-140	peroxisome proliferator activated receptor gamma	Homo sapiens	174-183
8875957-5	1996	IL-1beta increased the formation of both 13-HODE and 9-HODE in a concentration-dependent manner with similar EC50 values as for prostanoid formation.	9-hydroxy-10,12-octadecadienoic acid	53-59	interleukin 1 beta	Homo sapiens	0-8
9568715-3	1998	Moreover, we identify two of the major oxidized lipid components of oxLDL, 9-HODE and 13-HODE, as endogenous activators and ligands of PPARgamma.	9-hydroxy-10,12-octadecadienoic acid	75-81	peroxisome proliferator activated receptor gamma	Homo sapiens	135-144
10816426-6	2000	9-HODE was generated as the R enantiomer by the platelet-type and the epidermis-type isoenzymes and as the S enantiomer by the leucocyte-type (12S)-lipoxygenase.	9-hydroxy-10,12-octadecadienoic acid	0-6	arachidonate 12-lipoxygenase	Mus musculus	143-160
34942378-6	2022	Inhibition of COX-1 with aspirin, as expected, completely abolished production of TxA2 and PGD/E2, but also significantly inhibited the release of 11-HETE (89 +- 3%) and 9-HODE (74 +- 6%), and reduced 15-HETE and 13-HODE by ~33 %.	9-hydroxy-10,12-octadecadienoic acid	170-176	prostaglandin-endoperoxide synthase 1	Homo sapiens	14-19
1629217-7	1992	When tested for activity in macrophage culture (3 x 10(6) cells/culture), it was found that 9-HODE and 13-HODE (final concentration 33 microM) induced the release of 122 and 43 pg of IL-1 beta/culture, respectively, whereas untreated cells released only 4 pg of IL-1 beta/culture.	9-hydroxy-10,12-octadecadienoic acid	92-98	interleukin 1 beta	Homo sapiens	183-192
1629217-7	1992	When tested for activity in macrophage culture (3 x 10(6) cells/culture), it was found that 9-HODE and 13-HODE (final concentration 33 microM) induced the release of 122 and 43 pg of IL-1 beta/culture, respectively, whereas untreated cells released only 4 pg of IL-1 beta/culture.	9-hydroxy-10,12-octadecadienoic acid	92-98	interleukin 1 beta	Homo sapiens	262-271
1629217-8	1992	Incubation of macrophages with cholesteryl-9-HODE also induced IL-1 beta release; however, the degree of induction of IL-1 beta release by 9-HODE or its cholesteryl ester relative to modified LDL suggests that other components in oxidized LDL may also contribute to IL-1 beta induction.	9-hydroxy-10,12-octadecadienoic acid	43-49	interleukin 1 beta	Homo sapiens	63-72
1629217-10	1992	A 1.5- to 6-fold increase in the level of IL-1 beta mRNA was detected as little as 3-h post-9-HODE treatment.	9-hydroxy-10,12-octadecadienoic acid	92-98	interleukin 1 beta	Homo sapiens	42-51
1629217-11	1992	The induction of IL-1 beta release from human monocyte-derived macrophages by 9-HODE and cholesteryl-9-HODE suggests a role for modified LDL, and its associated linoleate oxidation products, in vascular smooth muscle cell proliferation.	9-hydroxy-10,12-octadecadienoic acid	78-84	interleukin 1 beta	Homo sapiens	17-26
35149052-4	2022	Most notably, the oxidized linoleic acid metabolite and partial TRPV1 agonist 9-HODE (hydroxyoctadecadienoic acid) was shown to be involved in this sensitization process.	9-hydroxy-10,12-octadecadienoic acid	78-84	transient receptor potential cation channel subfamily V member 1	Homo sapiens	64-69
31759597-10	2020	Inhibiting HSL activity partially reversed ISO effects on HODE and 9-oxoODE.	9-hydroxy-10,12-octadecadienoic acid	58-62	lipase E, hormone sensitive type	Bos taurus	11-14
3691528-6	1987	Studies of the interaction of 9-HODE with activation of platelet adenylate cyclase activity mediated by prostaglandin E1 (PGE1) and prostaglandin D2 (PGD2) indicated that this fatty acid produced a parallel shift in the concentration/response curve of PGE1 and PGD2 without altering maximal response, which was substantially greater than that observed with 9-HODE alone.	9-hydroxy-10,12-octadecadienoic acid	30-36	prostaglandin D2 synthase	Homo sapiens	150-154
3691528-6	1987	Studies of the interaction of 9-HODE with activation of platelet adenylate cyclase activity mediated by prostaglandin E1 (PGE1) and prostaglandin D2 (PGD2) indicated that this fatty acid produced a parallel shift in the concentration/response curve of PGE1 and PGD2 without altering maximal response, which was substantially greater than that observed with 9-HODE alone.	9-hydroxy-10,12-octadecadienoic acid	30-36	prostaglandin D2 synthase	Homo sapiens	261-265
3691528-7	1987	From these results, we conclude that 9-HODE appears to be a partial agonist at PGE1 and PGD2 receptors on human platelets.	9-hydroxy-10,12-octadecadienoic acid	37-43	prostaglandin D2 synthase	Homo sapiens	88-92
6775354-5	1980	The conversion of linoleic acid to monohydroxy C-18 fatty acids varied from 40-80% 9-HODD and 20-60% 13-HODD in tumor tissue harvested from different animals.	9-hydroxy-10,12-octadecadienoic acid	83-89	Bardet-Biedl syndrome 9	Homo sapiens	47-51
31992650-5	2020	Transcriptome analysis reveals 9-HODE functions by regulating FOXO family transcription factors.	9-hydroxy-10,12-octadecadienoic acid	31-37	forkhead box, sub-group O	Drosophila melanogaster	62-66
31992650-6	2020	We show 9-HODE activates JNK, triggering FOXO nuclear localisation and chromatin binding.	9-hydroxy-10,12-octadecadienoic acid	8-14	basket	Drosophila melanogaster	25-28
31992650-6	2020	We show 9-HODE activates JNK, triggering FOXO nuclear localisation and chromatin binding.	9-hydroxy-10,12-octadecadienoic acid	8-14	forkhead box, sub-group O	Drosophila melanogaster	41-45
31992650-8	2020	By activating FOXO, 9-HODE could antagonise insulin signaling providing a molecular conduit linking changes in dietary fatty acid balance, meta-inflammation, and insulin resistance.	9-hydroxy-10,12-octadecadienoic acid	20-26	forkhead box, sub-group O	Drosophila melanogaster	14-18
31992650-8	2020	By activating FOXO, 9-HODE could antagonise insulin signaling providing a molecular conduit linking changes in dietary fatty acid balance, meta-inflammation, and insulin resistance.	9-hydroxy-10,12-octadecadienoic acid	20-26	Insulin-like receptor	Drosophila melanogaster	44-51
31992650-8	2020	By activating FOXO, 9-HODE could antagonise insulin signaling providing a molecular conduit linking changes in dietary fatty acid balance, meta-inflammation, and insulin resistance.	9-hydroxy-10,12-octadecadienoic acid	20-26	Insulin-like receptor	Drosophila melanogaster	162-169
26538237-6	2016	Gene expression profiling and immunohistochemistry demonstrated that ADRB3 agonist treatment upregulated expression of ALOX15, the lipoxygenase responsible for generating 9-HODE and 13-HODE.	9-hydroxy-10,12-octadecadienoic acid	171-177	adrenergic receptor, beta 3	Mus musculus	69-74
31340670-5	2019	ApoE knockout mice exposed to inhaled diesel exhaust (DE, 6 h/d, 5 days/wk for 16 weeks) exhibited elevated plasma cholesterol and triglyceride levels, increased hepatic triglyceride content, and higher hepatic levels of 9-HODE and 13-HODE, as compared to control mice exposed to filtered air.	9-hydroxy-10,12-octadecadienoic acid	221-227	apolipoprotein E	Mus musculus	0-4
31155590-3	2019	Analysis by flow cytometry (FACS) with annexin V and propidium iodide (PI) staining showed that 9-(E,Z)-HODE induced apoptosis with G2/M phase arrest.	9-hydroxy-10,12-octadecadienoic acid	96-108	acyl-CoA synthetase long-chain family member 1	Mus musculus	28-32
31155590-3	2019	Analysis by flow cytometry (FACS) with annexin V and propidium iodide (PI) staining showed that 9-(E,Z)-HODE induced apoptosis with G2/M phase arrest.	9-hydroxy-10,12-octadecadienoic acid	96-108	annexin A5	Mus musculus	39-48
31155590-3	2019	Analysis by flow cytometry (FACS) with annexin V and propidium iodide (PI) staining showed that 9-(E,Z)-HODE induced apoptosis with G2/M phase arrest.	9-hydroxy-10,12-octadecadienoic acid	96-108	proline-rich coiled-coil 2A	Mus musculus	132-149
31155590-6	2019	The intracellular NEDD8 (ubiquitin-like protein) expression in EL4 cells was decreased by the treatment with 9-(E,Z)-HODE as assessed by immunoblotting and flow cytometry.	9-hydroxy-10,12-octadecadienoic acid	109-121	neural precursor cell expressed, developmentally down-regulated gene 8	Mus musculus	18-23
31155590-7	2019	In conclusion, 9-(E,Z)-HODE specifically induced G2/M phase arrest and apoptosis, and the decrease of NEDD8 expression might be involved in this effect.	9-hydroxy-10,12-octadecadienoic acid	15-27	proline-rich coiled-coil 2A	Mus musculus	49-66
31155590-7	2019	In conclusion, 9-(E,Z)-HODE specifically induced G2/M phase arrest and apoptosis, and the decrease of NEDD8 expression might be involved in this effect.	9-hydroxy-10,12-octadecadienoic acid	15-27	neural precursor cell expressed, developmentally down-regulated gene 8	Mus musculus	102-107
28303483-10	2017	Gene expression of PLA2G2A and ALOX15B was upregulated in lean and overweight/obese patients (p <= 0.05), whereas their end products, the PPARgamma-activating metabolites 15s-HETE and 9-HODE, were not increased in the adipose tissue.	9-hydroxy-10,12-octadecadienoic acid	187-193	phospholipase A2 group IIA	Homo sapiens	19-26
28303483-10	2017	Gene expression of PLA2G2A and ALOX15B was upregulated in lean and overweight/obese patients (p <= 0.05), whereas their end products, the PPARgamma-activating metabolites 15s-HETE and 9-HODE, were not increased in the adipose tissue.	9-hydroxy-10,12-octadecadienoic acid	187-193	arachidonate 15-lipoxygenase type B	Homo sapiens	31-38
26701313-4	2016	LPS increased the systemic and organ levels of proinflammatory metabolites of linoleic acid including leukotoxin diols (9-,10-DHOME, 12-,13-DHOME) and octadecadienoic acids (9-HODE and 13-HODE) and arachidonic acid-derived prostanoid, PGE2, and hydroxyeicosatetraenoic acids (8-, 12- and 15-HETE).	9-hydroxy-10,12-octadecadienoic acid	174-180	toll-like receptor 4	Mus musculus	0-3
26538237-6	2016	Gene expression profiling and immunohistochemistry demonstrated that ADRB3 agonist treatment upregulated expression of ALOX15, the lipoxygenase responsible for generating 9-HODE and 13-HODE.	9-hydroxy-10,12-octadecadienoic acid	171-177	arachidonate 15-lipoxygenase	Mus musculus	119-125
25794249-9	2015	Increased concentrations of 9-HODE, 13-HODE, and 15-HETE in phospholipids (2.1-, 2.1-, and 2.4-fold increase, respectively) were found in HDL from patients with T2D, and these HDL also inhibited platelet aggregation via SR-BI.	9-hydroxy-10,12-octadecadienoic acid	28-34	scavenger receptor class B member 1	Homo sapiens	220-225
24343898-5	2014	ADPKD patients with eGFR >60 ml/min/1.73 m(2) showed higher levels of 5- and 12/15-lipoxygenase (LOX) and cyclooxygenase, and generated higher levels of hydroxy-octadecadienoic acids 9-HODE and 13-HODE and HETEs 8-HETE, 11-HETE, 12-HETE, and 15-HETE as compared with healthy subjects.	9-hydroxy-10,12-octadecadienoic acid	186-192	epidermal growth factor receptor	Homo sapiens	20-24
25251539-5	2014	Upon examining the migratory response towards TECK/CCL25, it was observed that an increase in CCR9 expression upon pre-treatment with 9-S-HODE, 9-R-HODE, 13-R-HODE and LPC resulted in increased migration of monocytes expressing CCR9.	9-hydroxy-10,12-octadecadienoic acid	134-142	C-C motif chemokine ligand 25	Homo sapiens	46-50
25251539-5	2014	Upon examining the migratory response towards TECK/CCL25, it was observed that an increase in CCR9 expression upon pre-treatment with 9-S-HODE, 9-R-HODE, 13-R-HODE and LPC resulted in increased migration of monocytes expressing CCR9.	9-hydroxy-10,12-octadecadienoic acid	134-142	C-C motif chemokine ligand 25	Homo sapiens	51-56
25251539-5	2014	Upon examining the migratory response towards TECK/CCL25, it was observed that an increase in CCR9 expression upon pre-treatment with 9-S-HODE, 9-R-HODE, 13-R-HODE and LPC resulted in increased migration of monocytes expressing CCR9.	9-hydroxy-10,12-octadecadienoic acid	134-142	C-C motif chemokine receptor 9	Homo sapiens	94-98
25251539-5	2014	Upon examining the migratory response towards TECK/CCL25, it was observed that an increase in CCR9 expression upon pre-treatment with 9-S-HODE, 9-R-HODE, 13-R-HODE and LPC resulted in increased migration of monocytes expressing CCR9.	9-hydroxy-10,12-octadecadienoic acid	134-142	C-C motif chemokine receptor 9	Homo sapiens	228-232
25251539-7	2014	Finally, 9-S-HODE, 9-R-HODE, 13-R-HODE, or LPC inhibited the release of IL-6 from monocytes suggesting that these lipids may play important role in controlling inflammatory responses.	9-hydroxy-10,12-octadecadienoic acid	9-17	interleukin 6	Homo sapiens	72-76
23200035-5	2013	Addition of 9-S-HODE prior to the addition of LPC inhibited more than 50% of the effect of LPC, whereas addition of LPC prior to the addition of 9-S-HODE completely inhibited the effect of the latter lipid.	9-hydroxy-10,12-octadecadienoic acid	12-20	proprotein convertase subtilisin/kexin type 7	Homo sapiens	91-94
24343898-6	2014	Linear regression of 9-HODE and 13-HODE revealed a significant relationship with eGFR and TKV, while 15-HETE significantly correlated with TKV/BSAR.	9-hydroxy-10,12-octadecadienoic acid	21-27	epidermal growth factor receptor	Homo sapiens	81-85
23200035-5	2013	Addition of 9-S-HODE prior to the addition of LPC inhibited more than 50% of the effect of LPC, whereas addition of LPC prior to the addition of 9-S-HODE completely inhibited the effect of the latter lipid.	9-hydroxy-10,12-octadecadienoic acid	12-20	proprotein convertase subtilisin/kexin type 7	Homo sapiens	91-94
22861649-0	2012	A re-evaluation of 9-HODE activity at TRPV1 channels in comparison with anandamide: enantioselectivity and effects at other TRP channels and in sensory neurons.	9-hydroxy-10,12-octadecadienoic acid	19-25	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	38-43