PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33884017-1 2020 Background: Adenosine deaminase (ADA) is an aminohydrolase involved in the catabolism of purine nucleotides and irreversibly deaminizes adenosine and deoxyadenosine to inosine and deoxyinosine. 2'-deoxyadenosine 150-164 adenosine deaminase Homo sapiens 12-31 33884017-1 2020 Background: Adenosine deaminase (ADA) is an aminohydrolase involved in the catabolism of purine nucleotides and irreversibly deaminizes adenosine and deoxyadenosine to inosine and deoxyinosine. 2'-deoxyadenosine 150-164 adenosine deaminase Homo sapiens 33-36 31999420-1 2020 Clofarabine (2-chloro-2"-fluoro-2"-deoxyarabinosyladenine, ClF), a second-generation 2"-deoxyadenosine analog, possesses manifold anti-cancer activities. 2'-deoxyadenosine 85-102 CLQTL1 Homo sapiens 59-62 28230183-3 2017 We show that IDGF2 is independent of insulin and protects cells from death caused by serum deprivation, toxicity of xenobiotics or high concentrations of extracellular adenosine (Ado) and deoxyadenosine (dAdo). 2'-deoxyadenosine 188-202 Imaginal disc growth factor 2 Drosophila melanogaster 13-18 28429285-4 2018 In addition, we evaluated the effect of added THGP on the enzymatic activity of adenosine deaminase (ADA) when using adenosine or 2"-deoxyadenosine as a substrate. 2'-deoxyadenosine 130-147 adenosine deaminase Homo sapiens 80-99 28429285-4 2018 In addition, we evaluated the effect of added THGP on the enzymatic activity of adenosine deaminase (ADA) when using adenosine or 2"-deoxyadenosine as a substrate. 2'-deoxyadenosine 130-147 adenosine deaminase Homo sapiens 101-104 30221577-0 2018 Streptococcus suis synthesizes deoxyadenosine and adenosine by 5"-nucleotidase to dampen host immune responses. 2'-deoxyadenosine 31-45 5' nucleotidase, ecto Mus musculus 63-78 30221577-3 2018 Here, we show that S. suis 5"-nucleotidase not only enables producing 2"-deoxyadenosine from 2"-deoxyadenosine monophosphate by the enzymatic assay and reversed-phase high performance liquid chromatography (RP-HPLC) analysis in vitro, but also synthesizes both 2"-deoxyadenosine and adenosine in mouse blood in vivo by RP-HPLC and liquid chromatography with tandem mass spectrometry analyses. 2'-deoxyadenosine 70-87 5' nucleotidase, ecto Mus musculus 27-42 30221577-3 2018 Here, we show that S. suis 5"-nucleotidase not only enables producing 2"-deoxyadenosine from 2"-deoxyadenosine monophosphate by the enzymatic assay and reversed-phase high performance liquid chromatography (RP-HPLC) analysis in vitro, but also synthesizes both 2"-deoxyadenosine and adenosine in mouse blood in vivo by RP-HPLC and liquid chromatography with tandem mass spectrometry analyses. 2'-deoxyadenosine 93-110 5' nucleotidase, ecto Mus musculus 27-42 30221577-4 2018 Cellular cytotoxicity assay and Western blot analysis indicated that the production of 2"-deoxyadenosine by 5"-nucleotidase triggered the death of mouse macrophages RAW 264.7 in a caspase-3-dependent way. 2'-deoxyadenosine 87-104 5' nucleotidase, ecto Mus musculus 108-123 30221577-4 2018 Cellular cytotoxicity assay and Western blot analysis indicated that the production of 2"-deoxyadenosine by 5"-nucleotidase triggered the death of mouse macrophages RAW 264.7 in a caspase-3-dependent way. 2'-deoxyadenosine 87-104 caspase 3 Mus musculus 180-189 30221577-5 2018 The in vivo infection experiment showed that 2"-deoxyadenosine synthesized by 5"-nucleotidase caused monocytopenia in mouse blood. 2'-deoxyadenosine 45-62 5' nucleotidase, ecto Mus musculus 78-93 30221577-7 2018 Taken together, these findings indicate that S. suis synthesizes 2"-deoxyadenosine and adenosine by 5"-nucleotidase to dampen host immune responses, which represents a new mechanism of S. suis pathogenesis. 2'-deoxyadenosine 65-82 5' nucleotidase, ecto Mus musculus 100-115 28395138-14 2017 hPols eta and iota, Dpo4, and Klenow fragment were able to bypass the adduct with only slight impedance; hPol eta and iota showed increased misincorporation opposite the adduct compared to that of unmodified 2"-deoxyadenosine. 2'-deoxyadenosine 208-225 endothelin receptor type A Homo sapiens 6-9 28395138-14 2017 hPols eta and iota, Dpo4, and Klenow fragment were able to bypass the adduct with only slight impedance; hPol eta and iota showed increased misincorporation opposite the adduct compared to that of unmodified 2"-deoxyadenosine. 2'-deoxyadenosine 208-225 endothelin receptor type A Homo sapiens 110-113 29891696-4 2018 Here we used CRISPR-Cas9 mutagenesis to show that phagocyte intoxication involves uptake of dAdo via the human equilibrative nucleoside transporter 1, dAdo conversion to dAMP by deoxycytidine kinase and adenosine kinase, and signaling via subsequent dATP formation to activate caspase-3-induced cell death. 2'-deoxyadenosine 92-96 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 111-149 29891696-4 2018 Here we used CRISPR-Cas9 mutagenesis to show that phagocyte intoxication involves uptake of dAdo via the human equilibrative nucleoside transporter 1, dAdo conversion to dAMP by deoxycytidine kinase and adenosine kinase, and signaling via subsequent dATP formation to activate caspase-3-induced cell death. 2'-deoxyadenosine 92-96 caspase 3 Homo sapiens 277-286 27995448-7 2017 Binding of hENT1 to adenosine, deoxyadenosine, and adenine by isothermal titration calorimetry is in general agreement with results of the competitive inhibition assays. 2'-deoxyadenosine 31-45 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 11-16 28230183-3 2017 We show that IDGF2 is independent of insulin and protects cells from death caused by serum deprivation, toxicity of xenobiotics or high concentrations of extracellular adenosine (Ado) and deoxyadenosine (dAdo). 2'-deoxyadenosine 204-208 Imaginal disc growth factor 2 Drosophila melanogaster 13-18 27118477-6 2016 Another highlight, dABp-3 is based on 2"-deoxyadenosine, which result in its recognition capacity for RNA. 2'-deoxyadenosine 38-55 Disabled Drosophila melanogaster 19-23 27722620-0 2016 A kinetic mechanism of repair of DNA containing alpha-anomeric deoxyadenosine by human apurinic/apyrimidinic endonuclease 1. 2'-deoxyadenosine 63-77 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 87-123 29204093-1 2017 Introduction: Adenosine and deoxyadenosine metabolism is influenced by adenosine deaminase (ADA) enzyme. 2'-deoxyadenosine 28-42 adenosine deaminase Homo sapiens 71-90 29204093-1 2017 Introduction: Adenosine and deoxyadenosine metabolism is influenced by adenosine deaminase (ADA) enzyme. 2'-deoxyadenosine 28-42 adenosine deaminase Homo sapiens 92-95 27836324-6 2016 The steady-state kinetic parameters of reactions indicate that Arabidopsis ARP cleaves oligonucleotide duplexes containing alpha-anomeric 2"-deoxyadenosine (alphadA) and 5,6-dihydrouridine (DHU) with efficiencies (kcat/KM=134 and 7.3 muM-1 min-1, respectively) comparable to those of the human counterpart. 2'-deoxyadenosine 138-155 apurinic endonuclease-redox protein Arabidopsis thaliana 75-78 25875700-2 2015 Deficiency of the purine salvage enzyme ADA leads to the build-up of the toxic metabolites, deoxyadenosine triphosphate and deoxyadenosine. 2'-deoxyadenosine 92-106 adenosine deaminase Homo sapiens 40-43 26746865-1 2016 Adenosine deaminase (ADA) is a ubiquitous enzyme that catabolizes adenosine and deoxyadenosine. 2'-deoxyadenosine 80-94 adenosine deaminase Rattus norvegicus 0-19 26746865-1 2016 Adenosine deaminase (ADA) is a ubiquitous enzyme that catabolizes adenosine and deoxyadenosine. 2'-deoxyadenosine 80-94 adenosine deaminase Rattus norvegicus 21-24 26872394-3 2016 The 2"-deoxyadenosine derivative with a diazaphenoxazine skeleton at the 6-amino group (Adap) was shown to be selective for 8-oxo-dG in DNA. 2'-deoxyadenosine 4-21 FYN binding protein 1 Homo sapiens 88-92 25768656-5 2015 However, in this study we determined that incubation of 7-GS-DHP with 2"-deoxyguanosine (dG) and 2"-deoxyadenosine (dA) yields DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4 adducts as well as the reactive metabolite DHP. 2'-deoxyadenosine 97-114 dihydropyrimidinase Homo sapiens 61-64 25768656-5 2015 However, in this study we determined that incubation of 7-GS-DHP with 2"-deoxyguanosine (dG) and 2"-deoxyadenosine (dA) yields DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4 adducts as well as the reactive metabolite DHP. 2'-deoxyadenosine 97-114 dihydropyrimidinase Homo sapiens 127-130 25768656-5 2015 However, in this study we determined that incubation of 7-GS-DHP with 2"-deoxyguanosine (dG) and 2"-deoxyadenosine (dA) yields DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4 adducts as well as the reactive metabolite DHP. 2'-deoxyadenosine 97-114 dihydropyrimidinase Homo sapiens 127-130 25768656-5 2015 However, in this study we determined that incubation of 7-GS-DHP with 2"-deoxyguanosine (dG) and 2"-deoxyadenosine (dA) yields DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4 adducts as well as the reactive metabolite DHP. 2'-deoxyadenosine 97-114 dihydropyrimidinase Homo sapiens 127-130 25768656-5 2015 However, in this study we determined that incubation of 7-GS-DHP with 2"-deoxyguanosine (dG) and 2"-deoxyadenosine (dA) yields DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4 adducts as well as the reactive metabolite DHP. 2'-deoxyadenosine 97-114 dihydropyrimidinase Homo sapiens 127-130 25768656-5 2015 However, in this study we determined that incubation of 7-GS-DHP with 2"-deoxyguanosine (dG) and 2"-deoxyadenosine (dA) yields DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4 adducts as well as the reactive metabolite DHP. 2'-deoxyadenosine 97-114 dihydropyrimidinase Homo sapiens 127-130 25768656-5 2015 However, in this study we determined that incubation of 7-GS-DHP with 2"-deoxyguanosine (dG) and 2"-deoxyadenosine (dA) yields DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4 adducts as well as the reactive metabolite DHP. 2'-deoxyadenosine 116-118 dihydropyrimidinase Homo sapiens 61-64 25768656-5 2015 However, in this study we determined that incubation of 7-GS-DHP with 2"-deoxyguanosine (dG) and 2"-deoxyadenosine (dA) yields DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4 adducts as well as the reactive metabolite DHP. 2'-deoxyadenosine 116-118 dihydropyrimidinase Homo sapiens 127-130 25768656-5 2015 However, in this study we determined that incubation of 7-GS-DHP with 2"-deoxyguanosine (dG) and 2"-deoxyadenosine (dA) yields DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4 adducts as well as the reactive metabolite DHP. 2'-deoxyadenosine 116-118 dihydropyrimidinase Homo sapiens 127-130 25768656-5 2015 However, in this study we determined that incubation of 7-GS-DHP with 2"-deoxyguanosine (dG) and 2"-deoxyadenosine (dA) yields DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4 adducts as well as the reactive metabolite DHP. 2'-deoxyadenosine 116-118 dihydropyrimidinase Homo sapiens 127-130 25768656-5 2015 However, in this study we determined that incubation of 7-GS-DHP with 2"-deoxyguanosine (dG) and 2"-deoxyadenosine (dA) yields DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4 adducts as well as the reactive metabolite DHP. 2'-deoxyadenosine 116-118 dihydropyrimidinase Homo sapiens 127-130 25768656-5 2015 However, in this study we determined that incubation of 7-GS-DHP with 2"-deoxyguanosine (dG) and 2"-deoxyadenosine (dA) yields DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4 adducts as well as the reactive metabolite DHP. 2'-deoxyadenosine 116-118 dihydropyrimidinase Homo sapiens 127-130 25768656-6 2015 Furthermore, reaction of 7-GS-DHP with calf thymus DNA in aqueous solution at 37 C for 4, 8, 16, 24, 48, or 72 h, followed by enzymatic hydrolysis yielded DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4 adducts. 2'-deoxyadenosine 180-182 dihydropyrimidinase Homo sapiens 30-33 25768656-6 2015 Furthermore, reaction of 7-GS-DHP with calf thymus DNA in aqueous solution at 37 C for 4, 8, 16, 24, 48, or 72 h, followed by enzymatic hydrolysis yielded DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4 adducts. 2'-deoxyadenosine 180-182 dihydropyrimidinase Homo sapiens 156-159 25768656-6 2015 Furthermore, reaction of 7-GS-DHP with calf thymus DNA in aqueous solution at 37 C for 4, 8, 16, 24, 48, or 72 h, followed by enzymatic hydrolysis yielded DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4 adducts. 2'-deoxyadenosine 180-182 dihydropyrimidinase Homo sapiens 156-159 25768656-6 2015 Furthermore, reaction of 7-GS-DHP with calf thymus DNA in aqueous solution at 37 C for 4, 8, 16, 24, 48, or 72 h, followed by enzymatic hydrolysis yielded DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4 adducts. 2'-deoxyadenosine 180-182 dihydropyrimidinase Homo sapiens 156-159 25768656-6 2015 Furthermore, reaction of 7-GS-DHP with calf thymus DNA in aqueous solution at 37 C for 4, 8, 16, 24, 48, or 72 h, followed by enzymatic hydrolysis yielded DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4 adducts. 2'-deoxyadenosine 180-182 dihydropyrimidinase Homo sapiens 156-159 25768656-7 2015 Under our current experimental conditions, DHP-dA-3 and DHP-dA-4 adducts were formed in a trace amount from the reaction of 7,9-di-GS-DHP with dA. 2'-deoxyadenosine 47-49 dihydropyrimidinase Homo sapiens 43-46 25244939-5 2015 RESULTS: All tested human CRC tissues and cell lines that had microsatellite instability contained truncations in the regulatory deoxyadenosine tract element (DATE) of the HGF gene promoter. 2'-deoxyadenosine 129-143 hepatocyte growth factor Homo sapiens 172-175 24794680-5 2014 The enzyme is also distinct from the mammalian 5"-deoxy-5"-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28) in that it is able of the phosphorolysis of 2"-deoxyadenosine while mammalian MTAP cannot. 2'-deoxyadenosine 157-174 methylthioadenosine phosphorylase Homo sapiens 47-92 25447764-8 2015 In this work we demonstrate that after 8 h of incubation with deoxyadenosine and deoxycoformycin, caspase-8 is activated, mitochondrial mass increases and mitochondrial reactive oxygen species decrease. 2'-deoxyadenosine 62-76 caspase 8 Homo sapiens 98-107 25447764-9 2015 The addition of baicalein to the incubation medium reduces cell death and caspase-3 activity induced by deoxycoformycin and deoxyadenosine in combination. 2'-deoxyadenosine 124-138 caspase 3 Homo sapiens 74-83 24663077-2 2014 MET copy number gain (CNG) and an activating truncation in the HGF promoter (deoxyadenosine tract element, DATE+) were studied in tumors of 95 patients with advanced gastric cancer treated with palliative chemotherapy. 2'-deoxyadenosine 77-91 hepatocyte growth factor Homo sapiens 63-66 24246952-5 2014 It was demonstrated that anti-KL-6 monoclonal antibody shows an extremely specific and strong binding affinity toward MUC1 fragments carrying sialyl T antigen (Neu5Acalpha2,3Galbeta1,3GalNAcalpha1 ) at Pro-Asp-Thr-Arg motif when compared with other seven anti-MUC1 monoclonal antibodies such as VU-3D1, VU-12E1, VU-11E2, Ma552, VU-3C6, SM3, and DF3. 2'-deoxyadenosine 298-301 mucin 1, cell surface associated Homo sapiens 118-122 24366484-2 2014 Shorter variants of deoxyadenosine tract element (DATE) located in the HGF promoter region have been reported to enhance the expression of HGF. 2'-deoxyadenosine 20-34 hepatocyte growth factor Homo sapiens 71-74 24366484-2 2014 Shorter variants of deoxyadenosine tract element (DATE) located in the HGF promoter region have been reported to enhance the expression of HGF. 2'-deoxyadenosine 20-34 hepatocyte growth factor Homo sapiens 139-142 24794680-5 2014 The enzyme is also distinct from the mammalian 5"-deoxy-5"-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28) in that it is able of the phosphorolysis of 2"-deoxyadenosine while mammalian MTAP cannot. 2'-deoxyadenosine 157-174 methylthioadenosine phosphorylase Homo sapiens 94-98 24794680-5 2014 The enzyme is also distinct from the mammalian 5"-deoxy-5"-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28) in that it is able of the phosphorolysis of 2"-deoxyadenosine while mammalian MTAP cannot. 2'-deoxyadenosine 157-174 methylthioadenosine phosphorylase Homo sapiens 191-195 22897443-8 2012 Deoxyadenosine, deoxyguanosine and deoxycytidine kinase activities were encoded by a single AtdNK gene. 2'-deoxyadenosine 0-14 P-loop containing nucleoside triphosphate hydrolases superfamily protein Arabidopsis thaliana 92-97 24772956-2 2013 The gene for adenosine deaminase is located on chromosome 20q12-q13.11 and codes for an aminohydrolase that catalyzes the deamination of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. 2'-deoxyadenosine 151-165 adenosine deaminase Homo sapiens 13-32 24296317-1 2014 Clofarabine (2-chloro-2"-fluoro-2"-deoxyarabinosyladenine, ClF) is a second-generation 2"-deoxyadenosine analogue that is structurally related to cladribine (2-chloro-2"-deoxyadenosine, 2CdA) and fludarabine (9-beta-d-arabinosyl-2-fluoroadenine, F-ara-A). 2'-deoxyadenosine 87-104 CLQTL1 Homo sapiens 59-62 23248974-1 2012 Adenosine deaminase is an enzyme of the purine metabolism whose function is to convert adenosine to inosine and deoxyadenosine to deoxyinosine. 2'-deoxyadenosine 112-126 adenosine deaminase Homo sapiens 0-19 21463108-3 2011 dCF is a potent inhibitor of adenosine deaminase (ADA), and treatment results in the accumulation of deoxyadenosine (dAdo) and adenosine (Ado) in the plasma. 2'-deoxyadenosine 101-115 adenosine deaminase Homo sapiens 50-53 22353632-1 2012 Adenosine deaminase, which catalyzes the deamination of adenosine and deoxyadenosine, plays a central role in purine metabolism. 2'-deoxyadenosine 70-84 adenosine deaminase Homo sapiens 0-19 22315946-0 2012 Interaction of 2"-deoxyadenosine with cis-2-butene-1,4-dial: computational approach to analysis of multistep chemical reactions. 2'-deoxyadenosine 15-32 suppressor of cytokine signaling 2 Homo sapiens 38-43 22315946-1 2012 The computational analysis of multistep chemical interactions between 2"-deoxyadenosine and cis-2-butene-1,4-dial has been performed. 2'-deoxyadenosine 70-87 suppressor of cytokine signaling 2 Homo sapiens 92-97 22315946-7 2012 It has been revealed that simulated UV and NMR spectra of primary and secondary 2"-deoxyadenosine adducts of cis-2-butene-1,4-dial are in agreement with the experimental observations. 2'-deoxyadenosine 80-97 suppressor of cytokine signaling 2 Homo sapiens 109-114 21717014-3 2011 Our strategy started from its five 2"-deoxyadenosine residues (A5, A9, A11, A12, and A15) in the loop based on the capability of the N7 atom to form hydrogen bonds in tertiary structures. 2'-deoxyadenosine 35-52 DXS435E Homo sapiens 71-74 21717014-3 2011 Our strategy started from its five 2"-deoxyadenosine residues (A5, A9, A11, A12, and A15) in the loop based on the capability of the N7 atom to form hydrogen bonds in tertiary structures. 2'-deoxyadenosine 35-52 immunoglobulin kappa variable 2D-19 (pseudogene) Homo sapiens 76-79 21717014-3 2011 Our strategy started from its five 2"-deoxyadenosine residues (A5, A9, A11, A12, and A15) in the loop based on the capability of the N7 atom to form hydrogen bonds in tertiary structures. 2'-deoxyadenosine 35-52 immunoglobulin kappa variable 1-32 (pseudogene) Homo sapiens 85-88 21463108-5 2011 CdA is the chlorinated derivative of deoxyadenosine, is resistant to degradation by ADA, and accumulates in lymphocytes as CdATP. 2'-deoxyadenosine 37-51 cytidine deaminase Homo sapiens 0-3 22806868-1 2012 Nucleoside analogues are used widely for the treatment of viral diseases and cancer, however the preparation of some important intermediates of these nucleoside analogues, including 2"-deoxyadenosine (dAR) and 5-methyluridine (5-MU), remains inconvenient. 2'-deoxyadenosine 182-199 Allatostatin A receptor 2 Drosophila melanogaster 201-204 21242742-3 2011 Cladribine (2-chlorodeoxyadenosine [2-CdA]) is a synthetic chlorinated deoxyadenosine analog that is biologically active in selected cell types and provides targeted and sustained reduction of circulating T and B lymphocytes implicated in the pathogenesis of MS. 2'-deoxyadenosine 20-34 cytidine deaminase Homo sapiens 38-41 20872830-0 2011 Divergent effects of oxidatively induced modification to the C8 of 2"-deoxyadenosine on transcription factor binding: 8,5"(S)-cyclo-2"-deoxyadenosine inhibits the binding of multiple sequence specific transcription factors, while 8-oxo-2"-deoxyadenosine increases binding of CREB and NF-kappa B to DNA. 2'-deoxyadenosine 67-84 cAMP responsive element binding protein 1 Homo sapiens 275-279 20872830-0 2011 Divergent effects of oxidatively induced modification to the C8 of 2"-deoxyadenosine on transcription factor binding: 8,5"(S)-cyclo-2"-deoxyadenosine inhibits the binding of multiple sequence specific transcription factors, while 8-oxo-2"-deoxyadenosine increases binding of CREB and NF-kappa B to DNA. 2'-deoxyadenosine 67-84 nuclear factor kappa B subunit 1 Homo sapiens 284-294 22086524-1 2011 OBJECTIVE: Adenosine deaminase acts on adenosine and deoxyadenosine metabolism and modulates the immune response. 2'-deoxyadenosine 53-67 adenosine deaminase Homo sapiens 11-30 19297449-7 2009 Collectively, this evidence suggested that apical hCNT3 and basolateral hENT2 are involved in proximal tubular reabsorption of adenosine and some nucleoside drugs and that apical hENT1 and basolateral hOATs are involved in proximal tubular secretion of 2"-deoxyadenosine. 2'-deoxyadenosine 253-270 solute carrier family 28 member 3 Homo sapiens 50-55 21115912-1 2010 BACKGROUND: In this study, the effect of clofarabine, a new generation 2"-deoxyadenosine analogue, on promoter methylation and transcriptional activity of selected genes (PTEN, APC, RARB2, ZAP70) in K562 cells was assessed. 2'-deoxyadenosine 71-88 phosphatase and tensin homolog Homo sapiens 171-175 19959816-1 2010 Deoxycytidine kinase (dCK) phosphorylates deoxycytidine, deoxyguanosine, and deoxyadenosine and plays an important role in the salvage pathway of nucleoside metabolism. 2'-deoxyadenosine 77-91 deoxycytidine kinase Homo sapiens 0-20 19959816-1 2010 Deoxycytidine kinase (dCK) phosphorylates deoxycytidine, deoxyguanosine, and deoxyadenosine and plays an important role in the salvage pathway of nucleoside metabolism. 2'-deoxyadenosine 77-91 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 22-25 19229593-1 2009 Adenosine deaminase (ADA; EC 3.5.4.4) is a purine catabolic enzyme causing hydrolytic deamination of adenosine and 2"-deoxyadenosine to inosine and 2"-deoxyinosine. 2'-deoxyadenosine 115-132 adenosine deaminase Gallus gallus 0-19 19229593-1 2009 Adenosine deaminase (ADA; EC 3.5.4.4) is a purine catabolic enzyme causing hydrolytic deamination of adenosine and 2"-deoxyadenosine to inosine and 2"-deoxyinosine. 2'-deoxyadenosine 115-132 adenosine deaminase Gallus gallus 21-24 20606276-0 2010 Crystallization and preliminary X-ray analysis of human endonuclease 1 (APE1) in complex with an oligonucleotide containing a 5,6-dihydrouracil (DHU) or an alpha-anomeric 2"-deoxyadenosine (alphadA) modified base. 2'-deoxyadenosine 171-188 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 72-76 20606276-3 2010 APE1 was crystallized in the presence of a 15-mer DNA containing an oxidatively damaged base in a single central 5,6-dihydrouracil (DHU).T or alpha-anomeric 2"-deoxyadenosine (alphadA).T base pair. 2'-deoxyadenosine 157-174 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 0-4 18376879-2 2008 The global minima of both the deoxyadenosine (dA) and deoxyguanosine (dG) adducts adopted a syn conformation about the glycosidic bond due to the presence of an O5"-H...N3 hydrogen bond, where the anti minima are 20-30 kJ mol-1 higher in energy. 2'-deoxyadenosine 30-44 synemin Homo sapiens 92-95 19188684-4 2009 This HGF promoter element consists of a mononucleotide repeat of 30 deoxyadenosines (30As), which we have termed "deoxyadenosine tract element" (DATE). 2'-deoxyadenosine 68-82 hepatocyte growth factor Homo sapiens 5-8 19018008-7 2008 Our work reveals that multiple deoxynucleoside kinases are involved in the phosphorylation of deoxyadenosine when ADA is absent, and suggests an alternate therapeutic strategy for treatment of ADA-deficient patients. 2'-deoxyadenosine 94-108 adenosine deaminase Homo sapiens 114-117 18377927-5 2008 To unravel the structural basis for substrate promiscuity of dCK at both the nucleoside acceptor and nucleotide donor sites, we solved the crystal structures of the enzyme as ternary complexes with the two enantiomeric forms of dA (D-dA, or L-dA), with either UDP or ADP bound to the donor site. 2'-deoxyadenosine 228-230 sticky Drosophila melanogaster 61-64 18840621-1 2008 OBJECTIVE: Adenosine deaminase catalyzes the conversion of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. 2'-deoxyadenosine 73-87 adenosine deaminase Homo sapiens 11-30 18361501-1 2008 Human deoxycytidine kinase (dCK) is responsible for the phosphorylation of a number of clinically important nucleoside analogue prodrugs in addition to its natural substrates, 2"-deoxycytidine, 2"-deoxyguanosine, and 2"-deoxyadenosine. 2'-deoxyadenosine 217-234 deoxycytidine kinase Homo sapiens 6-26 18361501-1 2008 Human deoxycytidine kinase (dCK) is responsible for the phosphorylation of a number of clinically important nucleoside analogue prodrugs in addition to its natural substrates, 2"-deoxycytidine, 2"-deoxyguanosine, and 2"-deoxyadenosine. 2'-deoxyadenosine 217-234 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 28-31 18376879-2 2008 The global minima of both the deoxyadenosine (dA) and deoxyguanosine (dG) adducts adopted a syn conformation about the glycosidic bond due to the presence of an O5"-H...N3 hydrogen bond, where the anti minima are 20-30 kJ mol-1 higher in energy. 2'-deoxyadenosine 46-48 synemin Homo sapiens 92-95 17608435-0 2007 Fluorinated alcohol mediated control over cis vs trans opening of benzo[a]pyrene-7,8-diol 9,10-epoxides at C-10 by the exocyclic amino groups of O6-allyl protected deoxyguanosine and of deoxyadenosine. 2'-deoxyadenosine 186-200 homeobox C10 Homo sapiens 107-111 17680812-1 2007 Adenosine deaminase (ADA) deficiency is an inherited disorder which leads to elevated cellular levels of deoxyadenosine triphosphate (dATP) and systemic accumulation of its precursor, 2-deoxyadenosine. 2'-deoxyadenosine 184-200 adenosine deaminase Homo sapiens 0-19 17680812-1 2007 Adenosine deaminase (ADA) deficiency is an inherited disorder which leads to elevated cellular levels of deoxyadenosine triphosphate (dATP) and systemic accumulation of its precursor, 2-deoxyadenosine. 2'-deoxyadenosine 184-200 adenosine deaminase Homo sapiens 21-24 18218852-1 2008 Mutations in the adenosine deaminase (ADA) gene are responsible for a form of severe combined immunodeficiency (SCID) caused by the lymphotoxic accumulation of ADA substrates, adenosine and 2"-deoxy-adenosine. 2'-deoxyadenosine 190-208 adenosine deaminase Homo sapiens 17-36 18218852-1 2008 Mutations in the adenosine deaminase (ADA) gene are responsible for a form of severe combined immunodeficiency (SCID) caused by the lymphotoxic accumulation of ADA substrates, adenosine and 2"-deoxy-adenosine. 2'-deoxyadenosine 190-208 adenosine deaminase Homo sapiens 38-41 18343902-1 2008 Adenosine deaminase (ADA, EC 3.5.4.4) catalyses the irreversible deamination of adenosine and 2"-deoxyadenosine to inosine and 2"-deoxyinosine, respectively. 2'-deoxyadenosine 94-111 adenosine deaminase Bos taurus 0-19 18343902-1 2008 Adenosine deaminase (ADA, EC 3.5.4.4) catalyses the irreversible deamination of adenosine and 2"-deoxyadenosine to inosine and 2"-deoxyinosine, respectively. 2'-deoxyadenosine 94-111 adenosine deaminase Bos taurus 21-24 17073823-6 2007 The N46S/L266R DGUOK showed 14 and 10% residual activity as compared with controls with dG and deoxyadenosine as phosphate acceptors respectively. 2'-deoxyadenosine 95-109 deoxyguanosine kinase Homo sapiens 15-20 17499224-5 2007 Ecto-ADA revealed a low affinity to adenosine (Ado) and 2"-deoxyadenosine (2"-dAdo) (K(M)=286.30+/-40.38 microM and 287.14+/-46.50 microM, respectively). 2'-deoxyadenosine 56-73 adenosine deaminase Homo sapiens 5-8 17499224-5 2007 Ecto-ADA revealed a low affinity to adenosine (Ado) and 2"-deoxyadenosine (2"-dAdo) (K(M)=286.30+/-40.38 microM and 287.14+/-46.50 microM, respectively). 2'-deoxyadenosine 75-82 adenosine deaminase Homo sapiens 5-8 17490647-1 2007 Purine deoxyribonucleotides required for mitochondrial DNA replication are either imported from the cytosol or derived from phosphorylation of deoxyadenosine or deoxyguanosine catalyzed by mitochondrial deoxyguanosine kinase (DGUOK). 2'-deoxyadenosine 143-157 deoxyguanosine kinase Homo sapiens 203-224 17490647-1 2007 Purine deoxyribonucleotides required for mitochondrial DNA replication are either imported from the cytosol or derived from phosphorylation of deoxyadenosine or deoxyguanosine catalyzed by mitochondrial deoxyguanosine kinase (DGUOK). 2'-deoxyadenosine 143-157 deoxyguanosine kinase Homo sapiens 226-231 16608169-4 2006 The reaction of 2"-deoxyadenosine with acrolein resulted in the formation of four structurally different adducts (dAI, dAII, dAIII, dAIV). 2'-deoxyadenosine 16-33 Arrestin 1 Drosophila melanogaster 114-117 17234793-2 2007 To determine how the metabolism of the parent hormone 17beta-estradiol (E2) leads to the formation of DNA adducts, we used the recombinant, purified phase I enzyme, cytochrome P450 1B1 (CYP1B1), which is expressed in breast tissue, to oxidize E2 in the presence of 2"-deoxyguanosine or 2"-deoxyadenosine. 2'-deoxyadenosine 286-303 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 165-184 17234793-2 2007 To determine how the metabolism of the parent hormone 17beta-estradiol (E2) leads to the formation of DNA adducts, we used the recombinant, purified phase I enzyme, cytochrome P450 1B1 (CYP1B1), which is expressed in breast tissue, to oxidize E2 in the presence of 2"-deoxyguanosine or 2"-deoxyadenosine. 2'-deoxyadenosine 286-303 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 186-192 16608169-4 2006 The reaction of 2"-deoxyadenosine with acrolein resulted in the formation of four structurally different adducts (dAI, dAII, dAIII, dAIV). 2'-deoxyadenosine 16-33 Arrestin 2 Drosophila melanogaster 119-123 16473948-11 2006 We show that in living cells a major human AP endonuclease, Ape1, incises DNA containing alpha-anomeric 2"-deoxyadenosine, indicating that the intracellular environment supports NIR activity. 2'-deoxyadenosine 104-121 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 60-64 16724639-9 2006 The diagnosis of ADA deficiency requires measurements of plasma ADA and of deoxyadenosine metabolites. 2'-deoxyadenosine 75-89 adenosine deaminase Homo sapiens 17-20 16724639-11 2006 The metabolic basis of the immunodeficiency is likely related to the sensitivity of lymphocytes to the accumulation of the aberrant ADA substrates, e.g., adenosine and 2"-deoxyadenosine. 2'-deoxyadenosine 168-185 adenosine deaminase Homo sapiens 132-135 17175968-2 2006 In order to improve diagnostic value of ADA it is recommended to estimate activity of both ADA1 and ADA2 izoenzymes or 2"-deoxyadenosine/adenosine activity ratio. 2'-deoxyadenosine 119-136 adenosine deaminase Homo sapiens 40-43 16421443-4 2006 dCK has a broad substrate specificity, with a much higher activity to deoxycytidine than to deoxyadenosine and deoxyguanosine. 2'-deoxyadenosine 92-106 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 0-3 16929383-4 2006 The Michaelis constant, Km, evidences a higher affinity of both substrates (in particular of more toxic 2"-dAdo) for LADA and proves the modulation of toxic nucleoside neutralization in the extracellular medium due to complex formation between ADA and DPPIV-CD26. 2'-deoxyadenosine 104-111 dipeptidyl peptidase 4 Bos taurus 252-257 17175968-7 2006 The ADA level reached the diagnostic cut-off set for tuberculous effusions (40 U/L) in every 11 tuberculous exudates with the mean value of 85,3+/-47,1 U/L; in 9 of these the 2"-deoxyadenosine/adenosine ratio was less than 0,45. 2'-deoxyadenosine 175-192 adenosine deaminase Homo sapiens 4-7 17175968-10 2006 We concluded that ADA measured by the Giusti method proceeded by the dilution 1:8 of the pleural effusion samples very good differentiates tuberculous from malignant pleurisy, without the necessity to determine the 2"-deoxyadenosine/adenosine ratio. 2'-deoxyadenosine 215-232 adenosine deaminase Homo sapiens 18-21 15907156-1 2005 Adenosine deaminase (ADA) is an enzyme present in all organisms that catalyzes the irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine. 2'-deoxyadenosine 125-139 Adenosine deaminase Drosophila melanogaster 0-19 16188888-0 2005 Error-prone translesion synthesis by human DNA polymerase eta on DNA-containing deoxyadenosine adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene. 2'-deoxyadenosine 80-94 DNA polymerase eta Homo sapiens 43-61 16112907-3 2005 In PEG-ADA therapy, enzymatically active ADA continuously circulates to act as a metabolic sink, detoxifying the adenosine and deoxyadenosine metabolites that accumulate to high levels in the absence of ADA. 2'-deoxyadenosine 127-141 adenosine deaminase Homo sapiens 7-10 16112907-3 2005 In PEG-ADA therapy, enzymatically active ADA continuously circulates to act as a metabolic sink, detoxifying the adenosine and deoxyadenosine metabolites that accumulate to high levels in the absence of ADA. 2'-deoxyadenosine 127-141 adenosine deaminase Homo sapiens 41-44 16112907-3 2005 In PEG-ADA therapy, enzymatically active ADA continuously circulates to act as a metabolic sink, detoxifying the adenosine and deoxyadenosine metabolites that accumulate to high levels in the absence of ADA. 2'-deoxyadenosine 127-141 adenosine deaminase Homo sapiens 41-44 16202036-1 2005 In this study we have examined the cytotoxic effects of different concentrations of adenosine (Ado) and deoxyadenosine (dAdo) on human breast cancer cell lines. 2'-deoxyadenosine 104-118 ado Drosophila melanogaster 120-124 16202036-3 2005 However, in the presence of adenosine deaminase (ADA) inhibitor, EHNA, adenosine and deoxyadenosine led to significant growth inhibition of cells of the lines tested. 2'-deoxyadenosine 85-99 adenosine deaminase Homo sapiens 28-47 16202036-3 2005 However, in the presence of adenosine deaminase (ADA) inhibitor, EHNA, adenosine and deoxyadenosine led to significant growth inhibition of cells of the lines tested. 2'-deoxyadenosine 85-99 adenosine deaminase Homo sapiens 49-52 16044347-7 2005 CdA metabolic studies (influx and activation) in the presence of deoxyadenosine, deoxycytidine, or araC suggested that CdA enters cells by a deoxyadenosine-inhibitable transport system, which is different than that of araC and deoxycytidine transport system. 2'-deoxyadenosine 65-79 cytidine deaminase Homo sapiens 0-3 16044347-7 2005 CdA metabolic studies (influx and activation) in the presence of deoxyadenosine, deoxycytidine, or araC suggested that CdA enters cells by a deoxyadenosine-inhibitable transport system, which is different than that of araC and deoxycytidine transport system. 2'-deoxyadenosine 65-79 cytidine deaminase Homo sapiens 119-122 16044347-7 2005 CdA metabolic studies (influx and activation) in the presence of deoxyadenosine, deoxycytidine, or araC suggested that CdA enters cells by a deoxyadenosine-inhibitable transport system, which is different than that of araC and deoxycytidine transport system. 2'-deoxyadenosine 141-155 cytidine deaminase Homo sapiens 0-3 16044347-7 2005 CdA metabolic studies (influx and activation) in the presence of deoxyadenosine, deoxycytidine, or araC suggested that CdA enters cells by a deoxyadenosine-inhibitable transport system, which is different than that of araC and deoxycytidine transport system. 2'-deoxyadenosine 141-155 cytidine deaminase Homo sapiens 119-122 15907156-1 2005 Adenosine deaminase (ADA) is an enzyme present in all organisms that catalyzes the irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine. 2'-deoxyadenosine 125-139 Adenosine deaminase Drosophila melanogaster 21-24 15661655-6 2005 Both mMYH variants exhibit a significantly decreased affinity for duplexes containing noncleavable 2"-deoxyadenosine analogues. 2'-deoxyadenosine 99-116 mutY DNA glycosylase Mus musculus 5-9 16158821-1 2005 The cytotoxic action of the deoxyadenosine analogue 9-beta-D-arabinofuranosyl-2-fluoroadenine (F-ara-A) depends on the incorporation into DNA after being phosphorylated to F-ara-A triphosphate (F-ara-ATP) by deoxycytidine kinase (dCK). 2'-deoxyadenosine 28-42 deoxycytidine kinase Mus musculus 208-228 16158821-1 2005 The cytotoxic action of the deoxyadenosine analogue 9-beta-D-arabinofuranosyl-2-fluoroadenine (F-ara-A) depends on the incorporation into DNA after being phosphorylated to F-ara-A triphosphate (F-ara-ATP) by deoxycytidine kinase (dCK). 2'-deoxyadenosine 28-42 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 230-233 15752710-0 2005 Activation of deoxycytidine kinase by deoxyadenosine: implications in deoxyadenosine-mediated cytotoxicity. 2'-deoxyadenosine 38-52 deoxycytidine kinase Homo sapiens 14-34 15752710-0 2005 Activation of deoxycytidine kinase by deoxyadenosine: implications in deoxyadenosine-mediated cytotoxicity. 2'-deoxyadenosine 70-84 deoxycytidine kinase Homo sapiens 14-34 15752710-2 2005 Formation of dATP requires phosphorylation of deoxyadenosine by deoxycytidine kinase (dCK), the main nucleoside salvage enzyme in lymphoid cells. 2'-deoxyadenosine 46-60 deoxycytidine kinase Homo sapiens 64-84 15752710-2 2005 Formation of dATP requires phosphorylation of deoxyadenosine by deoxycytidine kinase (dCK), the main nucleoside salvage enzyme in lymphoid cells. 2'-deoxyadenosine 46-60 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 86-89 15752710-3 2005 Activation of dCK by a number of genotoxic agents including 2-chlorodeoxyadenosine, a deamination-resistant deoxyadenosine analogue, was found previously. 2'-deoxyadenosine 68-82 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 14-17 15752710-4 2005 Here, we show that deoxyadenosine itself is also a potent activator of dCK if its deamination was prevented by the adenosine deaminase inhibitor deoxycoformycin. 2'-deoxyadenosine 19-33 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 71-74 15752710-4 2005 Here, we show that deoxyadenosine itself is also a potent activator of dCK if its deamination was prevented by the adenosine deaminase inhibitor deoxycoformycin. 2'-deoxyadenosine 19-33 adenosine deaminase Homo sapiens 115-134 15533835-0 2005 Dual hydrolysis of diphosphate and triphosphate derivatives of oxidized deoxyadenosine by Orf17 (NtpA), a MutT-type enzyme. 2'-deoxyadenosine 72-86 putative transposase Escherichia coli 90-95 15533841-8 2005 In contrast, 2-hydroxyadenine removal by E. coli MutY was significantly reduced compared to adenine removal opposite both OG and G. Furthermore, dissociation constant measurements with duplexes containing noncleavable 2"-deoxyadenosine analogues indicate that mMYH is less sensitive to the structure of the base mispaired with OG or G than MutY. 2'-deoxyadenosine 218-235 mutY DNA glycosylase Mus musculus 260-264 14578314-1 2003 BACKGROUND: The diagnosis and monitoring of severe combined immunodeficiency disease (SCID) attributable to adenosine deaminase (ADA) deficiency requires measurements of ADA, purine nucleoside phosphorylase (PNP), and S-adenosyl-L-homocysteine-hydrolase (SAHH) activity and of deoxyadenosine metabolites. 2'-deoxyadenosine 277-291 adenosine deaminase Homo sapiens 108-127 15705418-2 2005 The metabolic basis of the immunodeficiency is likely related to the sensitivity of lymphocytes to the accumulation of the ADA substrates adenosine and 2"-deoxyadenosine. 2'-deoxyadenosine 152-169 adenosine deaminase Mus musculus 123-126 15816525-1 2005 A mouse leukemia L1210 cell line (Y8), selected for resistance to deoxyadenosine, has a markedly altered phenotypic expression that includes loss of sensitivity to dATP as an allosteric inhibitor of ribonucleotide reductase, increased expression of c-myc, c-fos and WAF1/p21, but decreased expression of p53. 2'-deoxyadenosine 66-80 FBJ osteosarcoma oncogene Mus musculus 256-261 15816525-1 2005 A mouse leukemia L1210 cell line (Y8), selected for resistance to deoxyadenosine, has a markedly altered phenotypic expression that includes loss of sensitivity to dATP as an allosteric inhibitor of ribonucleotide reductase, increased expression of c-myc, c-fos and WAF1/p21, but decreased expression of p53. 2'-deoxyadenosine 66-80 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 266-270 15816525-1 2005 A mouse leukemia L1210 cell line (Y8), selected for resistance to deoxyadenosine, has a markedly altered phenotypic expression that includes loss of sensitivity to dATP as an allosteric inhibitor of ribonucleotide reductase, increased expression of c-myc, c-fos and WAF1/p21, but decreased expression of p53. 2'-deoxyadenosine 66-80 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 271-274 15816525-1 2005 A mouse leukemia L1210 cell line (Y8), selected for resistance to deoxyadenosine, has a markedly altered phenotypic expression that includes loss of sensitivity to dATP as an allosteric inhibitor of ribonucleotide reductase, increased expression of c-myc, c-fos and WAF1/p21, but decreased expression of p53. 2'-deoxyadenosine 66-80 transformation related protein 53, pseudogene Mus musculus 304-307 15606136-2 2004 cis-2-Butene-1,4-dial, the metabolite considered responsible for furan"s toxicological effects, is mutagenic in the Ames assay and reacts with 2"-deoxycytidine (dCyd), 2"-deoxyadenosine (dAdo), and 2"-deoxyguanosine (dGuo) to form previously characterized diastereomeric adducts. 2'-deoxyadenosine 168-185 suppressor of cytokine signaling 2 Homo sapiens 0-5 15606136-2 2004 cis-2-Butene-1,4-dial, the metabolite considered responsible for furan"s toxicological effects, is mutagenic in the Ames assay and reacts with 2"-deoxycytidine (dCyd), 2"-deoxyadenosine (dAdo), and 2"-deoxyguanosine (dGuo) to form previously characterized diastereomeric adducts. 2'-deoxyadenosine 187-191 suppressor of cytokine signaling 2 Homo sapiens 0-5 15508788-1 2004 Adenosine deaminase (ADA) is an unique enzyme which catalyzes conversion of adenosine and 2"-deoxyadenosine to inosine and 2"-deoxyinosine respectively. 2'-deoxyadenosine 90-107 adenosine deaminase Homo sapiens 0-19 15508788-1 2004 Adenosine deaminase (ADA) is an unique enzyme which catalyzes conversion of adenosine and 2"-deoxyadenosine to inosine and 2"-deoxyinosine respectively. 2'-deoxyadenosine 90-107 adenosine deaminase Homo sapiens 21-24 14578314-1 2003 BACKGROUND: The diagnosis and monitoring of severe combined immunodeficiency disease (SCID) attributable to adenosine deaminase (ADA) deficiency requires measurements of ADA, purine nucleoside phosphorylase (PNP), and S-adenosyl-L-homocysteine-hydrolase (SAHH) activity and of deoxyadenosine metabolites. 2'-deoxyadenosine 277-291 adenosine deaminase Homo sapiens 129-132 12808445-1 2003 Human deoxycytidine kinase (dCK) phosphorylates the natural deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA) and is an essential enzyme for the phosphorylation of numerous nucleoside analog prodrugs routinely used in cancer and antiviral chemotherapy. 2'-deoxyadenosine 125-139 deoxycytidine kinase Homo sapiens 6-26 14565765-1 2003 The product ion formation characteristics of four diastereomeric deoxyadenosine adducts formed by the reaction of the syn and anti diastereomers of trans-3,4-dihydroxy-5,5a-epoxy-3,4,5,5a-tetrahydrobenzo[ghi]fluoranthene are studied by matrix-assisted laser desorption ionization and postsource decay (PSD) to determine fragmentation pathways that may permit differentiation of their structures. 2'-deoxyadenosine 65-79 synemin Homo sapiens 118-121 14555239-1 2003 Adenosine deaminase (ADA) catalyzes the conversion of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. 2'-deoxyadenosine 68-82 adenosine deaminase Homo sapiens 0-19 14555239-9 2003 dATP levels were normalized and thymocyte development was rescued in cultures treated with an inhibitor of adenosine kinase, the enzyme that phosphorylates deoxyadenosine to dAMP. 2'-deoxyadenosine 156-170 adenosine kinase Homo sapiens 107-123 12808445-1 2003 Human deoxycytidine kinase (dCK) phosphorylates the natural deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA) and is an essential enzyme for the phosphorylation of numerous nucleoside analog prodrugs routinely used in cancer and antiviral chemotherapy. 2'-deoxyadenosine 125-139 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 28-31 12808445-1 2003 Human deoxycytidine kinase (dCK) phosphorylates the natural deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA) and is an essential enzyme for the phosphorylation of numerous nucleoside analog prodrugs routinely used in cancer and antiviral chemotherapy. 2'-deoxyadenosine 141-143 deoxycytidine kinase Homo sapiens 6-26 12808445-1 2003 Human deoxycytidine kinase (dCK) phosphorylates the natural deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA) and is an essential enzyme for the phosphorylation of numerous nucleoside analog prodrugs routinely used in cancer and antiviral chemotherapy. 2'-deoxyadenosine 141-143 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 28-31 12694532-5 2003 Adenine, adenosine, and all of the 2"-deoxynucleosides inhibited the Ran-GEF activity of RCC1; however, only adenine and 2"-deoxyadenosine (2"-dA) induced PCC. 2'-deoxyadenosine 121-138 regulator of chromosome condensation Mesocricetus auratus 89-93 12694532-0 2003 Caffeine mimics adenine and 2"-deoxyadenosine, both of which inhibit the guanine-nucleotide exchange activity of RCC1 and the kinase activity of ATR. 2'-deoxyadenosine 28-45 regulator of chromosome condensation Mesocricetus auratus 113-117 12694532-0 2003 Caffeine mimics adenine and 2"-deoxyadenosine, both of which inhibit the guanine-nucleotide exchange activity of RCC1 and the kinase activity of ATR. 2'-deoxyadenosine 28-45 serine/threonine-protein kinase ATR Mesocricetus auratus 145-148 12694532-5 2003 Adenine, adenosine, and all of the 2"-deoxynucleosides inhibited the Ran-GEF activity of RCC1; however, only adenine and 2"-deoxyadenosine (2"-dA) induced PCC. 2'-deoxyadenosine 140-145 regulator of chromosome condensation Mesocricetus auratus 89-93 12694532-7 2003 We found that both adenine and 2"-dA, but none of the other 2"-deoxynucleosides, inhibited the kinase activity of ATR, similar to that of caffeine. 2'-deoxyadenosine 31-36 serine/threonine-protein kinase ATR Mesocricetus auratus 114-117 12694532-9 2003 CONCLUSION: The effect of caffeine on cell-cycle control mimics the biological effect of adenine and 2"-dA, both of which inhibit ATR. 2'-deoxyadenosine 101-106 serine/threonine-protein kinase ATR Mesocricetus auratus 130-133 12694532-10 2003 dATP, a final metabolite of adenine and 2"-dA, is suggested to inhibit ATR, resulting in PCC. 2'-deoxyadenosine 40-45 serine/threonine-protein kinase ATR Mesocricetus auratus 71-74 12466554-0 2002 Translesion replication of benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyadenosine and deoxyguanosine by human DNA polymerase iota. 2'-deoxyadenosine 91-105 DNA polymerase iota Homo sapiens 134-153 12791380-0 2003 Inhibitors of diverse metabolic steps cause increased apoptosis in deoxyadenosine-resistant mouse leukemia L1210 cells that lack p53 expression: convergence at caspase-3 activation. 2'-deoxyadenosine 67-81 transformation related protein 53, pseudogene Mus musculus 129-132 12791380-0 2003 Inhibitors of diverse metabolic steps cause increased apoptosis in deoxyadenosine-resistant mouse leukemia L1210 cells that lack p53 expression: convergence at caspase-3 activation. 2'-deoxyadenosine 67-81 caspase 3 Mus musculus 160-169 12482237-5 2002 The reaction of 2"-deoxyadenosine with (1-chloroethenyl)oxirane gave two adducts: N1-(3-chloro-2-hydroxy-3-buten-1-yl)-2"-deoxyadenosine (dAI) and N(6)-(3-chloro-2-hydroxy-3-buten-1-yl)-2"-deoxyadenosine (dAII). 2'-deoxyadenosine 16-33 Arrestin 2 Drosophila melanogaster 205-209 12552998-1 2002 An L1210 cell line (Y8) selected for resistance to deoxyadenosine does not express p53 mRNA or protein but expresses WAF1/p21 even under basal conditions. 2'-deoxyadenosine 51-65 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 117-121 12552998-1 2002 An L1210 cell line (Y8) selected for resistance to deoxyadenosine does not express p53 mRNA or protein but expresses WAF1/p21 even under basal conditions. 2'-deoxyadenosine 51-65 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 122-125 12537017-4 2002 Here we describe the synthesis of an analog of 2"-deoxyadenosine that retains its Watson-Crick functional groups, but cannot form the syn conformation. 2'-deoxyadenosine 47-64 synemin Homo sapiens 21-24 12367777-1 2002 BACKGROUND: Adenosine deaminase (AD) and xanthine oxidase (XO) are enzymes of purine catabolism that catalyze the conversion of adenosine to inosine, deoxyadenosine to deoxyinosine, hypoxanthine to xanthine and xanthine to uric acid, respectively. 2'-deoxyadenosine 150-164 adenosine deaminase Homo sapiens 12-31 12367777-1 2002 BACKGROUND: Adenosine deaminase (AD) and xanthine oxidase (XO) are enzymes of purine catabolism that catalyze the conversion of adenosine to inosine, deoxyadenosine to deoxyinosine, hypoxanthine to xanthine and xanthine to uric acid, respectively. 2'-deoxyadenosine 150-164 adenosine deaminase Homo sapiens 33-35 11687801-5 2001 Human dGK efficiently phosphorylates deoxyguanosine and deoxyadenosine, whereas TK2 phosphorylates deoxythymidine, deoxycytidine and deoxyuridine. 2'-deoxyadenosine 56-70 Diacyl glycerol kinase Drosophila melanogaster 6-9 11896685-3 2002 Consistent with this observation, cis-2-butene-1,4-dial reacts with 2"-deoxycytidine, 2"-deoxyguanosine, and 2"-deoxyadenosine to form diastereomeric adducts. 2'-deoxyadenosine 109-126 suppressor of cytokine signaling 2 Homo sapiens 34-39 11896685-9 2002 These adducts resulted from the addition of cis-2-butene-1,4-dial to the exo- and endocyclic nitrogens of 2"-deoxyadenosine and 2"-deoxyguanosine. 2'-deoxyadenosine 106-123 suppressor of cytokine signaling 2 Homo sapiens 44-49 11941977-2 2002 BAT-26, a repeat of 26 deoxyadenosine localized in intron 5 of hMSH2 gene, has been reported as a reliable indicator of replication error phenotype in colorectal cancers. 2'-deoxyadenosine 23-37 mutS homolog 2 Homo sapiens 63-68 12537017-6 2002 This modification sterically prevents the syn conformation and 3mddA becomes an anti-fixed nucleoside analog of 2"-deoxyadenosine. 2'-deoxyadenosine 112-129 synemin Homo sapiens 42-45 11697955-1 2001 Alkylating agents that react through highly electrophilic quinone methide intermediates often express a specificity for the weakly nucleophilic exocyclic amines of deoxyguanosine (dG N(2)) and deoxyadenosine (dA N(6)) in DNA. 2'-deoxyadenosine 193-207 Odorant receptor 59a Drosophila melanogaster 209-216 11911251-1 2001 A mouse leukemia L1210 cell line (Y8) selected for resistance to deoxyadenosine was found to be deficient in the expression of p53 mRNA and protein while maintaining the expression of WAF1/p21 mRNA and protein even under basal conditions. 2'-deoxyadenosine 65-79 transformation related protein 53, pseudogene Mus musculus 127-130 11911251-1 2001 A mouse leukemia L1210 cell line (Y8) selected for resistance to deoxyadenosine was found to be deficient in the expression of p53 mRNA and protein while maintaining the expression of WAF1/p21 mRNA and protein even under basal conditions. 2'-deoxyadenosine 65-79 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 184-188 11911251-1 2001 A mouse leukemia L1210 cell line (Y8) selected for resistance to deoxyadenosine was found to be deficient in the expression of p53 mRNA and protein while maintaining the expression of WAF1/p21 mRNA and protein even under basal conditions. 2'-deoxyadenosine 65-79 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 189-192 11299731-2 2001 These deoxyadenosine-resistant cells (Y8) also do not express p53 protein but do have WAF1 and Gadd45 mRNA and protein. 2'-deoxyadenosine 6-20 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 86-90 11562990-0 2001 The NMR conformation study of the complexes of deoxycytidine kinase (dCK) and 2"-deoxycytidine/2"-deoxyadenosine. 2'-deoxyadenosine 95-112 deoxycytidine kinase Homo sapiens 47-67 11562990-0 2001 The NMR conformation study of the complexes of deoxycytidine kinase (dCK) and 2"-deoxycytidine/2"-deoxyadenosine. 2'-deoxyadenosine 95-112 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 69-72 11223861-1 2001 Adenosine deaminase (ADA) is an enzyme of the purine metabolism which catalyzes the irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. 2'-deoxyadenosine 126-140 adenosine deaminase Homo sapiens 0-19 11223861-1 2001 Adenosine deaminase (ADA) is an enzyme of the purine metabolism which catalyzes the irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. 2'-deoxyadenosine 126-140 adenosine deaminase Homo sapiens 21-24 11357058-1 2001 Adenosine deaminase (ADA) regulates cellular levels of adenosine and deoxyadenosine, and 17beta-estradiol (E(2)) induces ADA mRNA in MCF-7 human breast cancer cells. 2'-deoxyadenosine 69-83 adenosine deaminase Homo sapiens 0-19 11357058-1 2001 Adenosine deaminase (ADA) regulates cellular levels of adenosine and deoxyadenosine, and 17beta-estradiol (E(2)) induces ADA mRNA in MCF-7 human breast cancer cells. 2'-deoxyadenosine 69-83 adenosine deaminase Homo sapiens 21-24 11299731-2 2001 These deoxyadenosine-resistant cells (Y8) also do not express p53 protein but do have WAF1 and Gadd45 mRNA and protein. 2'-deoxyadenosine 6-20 growth arrest and DNA-damage-inducible 45 alpha Mus musculus 95-101 12836258-2 2001 The method consists of the chemical synthesis of 2"-deoxyribose 1-phosphate (dRP) and the enzymatic conversions of dRP into 2"-deoxyadenosine (dA), 2"-deoxyguanosine (dG) and 2"-deoxycytidine (dC). 2'-deoxyadenosine 124-141 drp Drosophila melanogaster 115-118 11154902-2 2001 The majority of antisense nucleosides (14 deoxyuridine and 11 deoxyadenosine derivatives) interacted with GCD, which probably led to inclusion complex formation. 2'-deoxyadenosine 62-76 guanylate cyclase 2E, pseudogene Homo sapiens 106-109 12836258-2 2001 The method consists of the chemical synthesis of 2"-deoxyribose 1-phosphate (dRP) and the enzymatic conversions of dRP into 2"-deoxyadenosine (dA), 2"-deoxyguanosine (dG) and 2"-deoxycytidine (dC). 2'-deoxyadenosine 143-145 drp Drosophila melanogaster 115-118 11205244-0 2000 Apoptosis induced by inhibitors of nucleotide synthesis in deoxyadenosine-resistant leukemia L1210 cells that lack p53 expression. 2'-deoxyadenosine 59-73 transformation related protein 53, pseudogene Mus musculus 115-118 11071652-2 2000 To explain why deoxyadenosine and its analogs are toxic to a cell that is not undergoing replicative DNA synthesis, several mechanisms have been proposed, including the direct binding of dATP to the pro-apoptotic factor Apaf-1 and the activation of the caspase-9 and -3 pathways. 2'-deoxyadenosine 15-29 apoptotic peptidase activating factor 1 Homo sapiens 220-226 11071652-2 2000 To explain why deoxyadenosine and its analogs are toxic to a cell that is not undergoing replicative DNA synthesis, several mechanisms have been proposed, including the direct binding of dATP to the pro-apoptotic factor Apaf-1 and the activation of the caspase-9 and -3 pathways. 2'-deoxyadenosine 15-29 caspase 9 Homo sapiens 253-269 10899903-1 2000 Adenosine deaminase (ADA) is a purine catabolic enzyme that manages levels of the biologically active purines adenosine and 2"-deoxyadenosine in tissues and cells. 2'-deoxyadenosine 124-141 adenosine deaminase Mus musculus 0-19 10942399-2 2000 However, previous studies have shown that in the presence of 2"-deoxyadenosine (dAd), human monocytoid leukemia cell lines are much more sensitive to dCF with regard to the inhibition of cell proliferation. 2'-deoxyadenosine 61-78 Daughters against dpp Drosophila melanogaster 80-83 10899903-1 2000 Adenosine deaminase (ADA) is a purine catabolic enzyme that manages levels of the biologically active purines adenosine and 2"-deoxyadenosine in tissues and cells. 2'-deoxyadenosine 124-141 adenosine deaminase Mus musculus 21-24 10899903-7 2000 Lowering adenosine and 2"-deoxyadenosine levels using ADA enzyme therapy decreased the pulmonary eosinophilia and resolved many of the lung histopathologies. 2'-deoxyadenosine 23-40 adenosine deaminase Mus musculus 54-57 10708967-0 2000 Mutagenicity of benzo[a]pyrene-deoxyadenosine adducts in a sequence context derived from the p53 gene. 2'-deoxyadenosine 31-45 tumor protein p53 Homo sapiens 93-96 10845921-1 2000 Adenosine deaminase (ADA) deficiency causes severe combined immunodeficiency (SCID) and is accompanied by T-cell depletion and accumulation of both intracellular and extracellular adenosine (extAdo) and deoxyadenosine. 2'-deoxyadenosine 203-217 adenosine deaminase Mus musculus 0-19 10837018-7 2000 Under the same exposure and chromatographic conditions, DNA adducts of deoxyadenosine and deoxyguanosine derived from the fjord region anti-DB[a,l]P-11,12-diol-13,14-epoxide and syn-DB[a,l]P-11,12-diol-13,14-epoxide were observed in the DNA of DB[a,l]P-treated cells. 2'-deoxyadenosine 71-85 joined toes Mus musculus 178-181 10930997-6 2000 Accordingly, the combination of dCF (10-100 microM) plus dAdo was able to induce a dose-dependent inhibition of clonogenic growth and [3H]-thymidine incorporation in purified CD3+/CD4-/CD8- gammadelta+ tumour cells. 2'-deoxyadenosine 57-61 CD4 molecule Homo sapiens 180-183 10930997-6 2000 Accordingly, the combination of dCF (10-100 microM) plus dAdo was able to induce a dose-dependent inhibition of clonogenic growth and [3H]-thymidine incorporation in purified CD3+/CD4-/CD8- gammadelta+ tumour cells. 2'-deoxyadenosine 57-61 CD8a molecule Homo sapiens 185-188 10708967-4 2000 This manuscript reports on the mutagenic consequences of replication past anti-BaPDE-deoxyadenosine adducts located within a sequence context related to codon 157 in exon 5 of the p53 gene. 2'-deoxyadenosine 85-99 tumor protein p53 Homo sapiens 180-183 10718633-6 2000 Km values of the small intestinal ADA for adenosine and 2"-deoxyadenosine were 23 and 16 microM, respectively. 2'-deoxyadenosine 56-73 adenosine deaminase Mus musculus 34-37 10853264-2 2000 Selection in the presence of either the herbicide Basta or the adenosine analogue 2"-deoxyadenosine resulted in transgenic cultures that expressed GUS and accumulated a 41-kD protein that immunoprecipated with an ADA-specific polyclonal antibody. 2'-deoxyadenosine 82-99 adenosine deaminase Mus musculus 213-216 10853264-4 2000 Culltures expressing ADA grew in the presence of 200 mg/l 2"-deoxyadenosine, a concentration which completely inhibited the growth of non-transgenic cultures. 2'-deoxyadenosine 58-75 adenosine deaminase Mus musculus 21-24 10673097-1 2000 The 3"-C-branched-adenosine and 2"-deoxyadenosine analogues 1-7 were tested as substrate of adenosine deaminase. 2'-deoxyadenosine 32-49 adenosine deaminase Homo sapiens 92-111 10607474-0 1999 Protection by various deoxynucleosides against deoxyadenosine-induced DNA damage in adenosine deaminase-inactivated lymphocytes. 2'-deoxyadenosine 47-61 adenosine deaminase Homo sapiens 84-103 10596453-1 1999 BACKGROUND: Adenosine deaminase (ADA) catalyzes hydrolytic and irreversible deamination of deoxyadenosine into deoxyinosine and of adenosine into inosine, and is related to lymphocytic proliferation and differentiation. 2'-deoxyadenosine 91-105 adenosine deaminase Homo sapiens 33-36 10575360-0 1999 Low enantioselectivities of human deoxycytidine kinase and human deoxyguanosine kinase with respect to 2"-deoxyadenosine, 2"-deoxyguanosine and their analogs. 2'-deoxyadenosine 103-120 deoxycytidine kinase Homo sapiens 34-54 10575360-0 1999 Low enantioselectivities of human deoxycytidine kinase and human deoxyguanosine kinase with respect to 2"-deoxyadenosine, 2"-deoxyguanosine and their analogs. 2'-deoxyadenosine 103-120 deoxyguanosine kinase Homo sapiens 65-86 10382272-3 1999 In the presence of an adenosine deaminase inhibitor, adenosine and 2"-deoxyadenosine (2"-dAdo) produced different toxicity patterns: both adenosine and 2"-dAdo were toxic to E3 embryos, but only 2"-dAdo was toxic at later stages (E6 1/2, E11). 2'-deoxyadenosine 67-84 skull morphology 7 Mus musculus 230-241 10490497-0 1999 Spectral and conformational analysis of deoxyadenosine adducts derived from syn- and anti-Dibenzo[a,l]pyrene diol epoxides: fluorescence studies. 2'-deoxyadenosine 40-54 synemin Homo sapiens 76-79 10423569-2 1999 The nucleosides 2"-deoxycytidine, thymidine, 2"-deoxyadenosine, 2"-deoxyguanosine, cytidine, adenosine and guanosine form 1 : 1 and 2 : 1 adducts with [Cr(salprn)](+), whereas the dinucleotides CpG, GpC, ApT, TpA and TpC form only the 1 : 1 adducts. 2'-deoxyadenosine 45-62 glycophorin C (Gerbich blood group) Homo sapiens 199-202 10423569-2 1999 The nucleosides 2"-deoxycytidine, thymidine, 2"-deoxyadenosine, 2"-deoxyguanosine, cytidine, adenosine and guanosine form 1 : 1 and 2 : 1 adducts with [Cr(salprn)](+), whereas the dinucleotides CpG, GpC, ApT, TpA and TpC form only the 1 : 1 adducts. 2'-deoxyadenosine 45-62 LYPLA2 pseudogene 1 Homo sapiens 204-207 10382272-3 1999 In the presence of an adenosine deaminase inhibitor, adenosine and 2"-deoxyadenosine (2"-dAdo) produced different toxicity patterns: both adenosine and 2"-dAdo were toxic to E3 embryos, but only 2"-dAdo was toxic at later stages (E6 1/2, E11). 2'-deoxyadenosine 86-93 skull morphology 7 Mus musculus 230-241 10382272-3 1999 In the presence of an adenosine deaminase inhibitor, adenosine and 2"-deoxyadenosine (2"-dAdo) produced different toxicity patterns: both adenosine and 2"-dAdo were toxic to E3 embryos, but only 2"-dAdo was toxic at later stages (E6 1/2, E11). 2'-deoxyadenosine 152-159 skull morphology 7 Mus musculus 230-241 10382272-3 1999 In the presence of an adenosine deaminase inhibitor, adenosine and 2"-deoxyadenosine (2"-dAdo) produced different toxicity patterns: both adenosine and 2"-dAdo were toxic to E3 embryos, but only 2"-dAdo was toxic at later stages (E6 1/2, E11). 2'-deoxyadenosine 152-159 skull morphology 7 Mus musculus 230-241 10382272-4 1999 Dosage experiments on E6 1/2 embryos showed that adenosine was less toxic than 2"-dAdo and that 2"-dAdo in sublethal doses was teratogenic. 2'-deoxyadenosine 96-103 skull morphology 8 Mus musculus 22-28 10382272-5 1999 We also examined the effects of 2"-dAdo on embryonic chicken SG and optic tectum in vivo to determine whether sublethal doses of 2"-dAdo produced cell death in these centers on E6 1/2 and 10. 2'-deoxyadenosine 129-136 skull morphology 8 Mus musculus 177-183 10382272-6 1999 In the E6 1/2 SG, 2"-dAdo produced significant neuron loss (83%) and a decrease in SG volume (65%); however, at E10, there was only minor cell loss (7%) and no significant change in SG volume. 2'-deoxyadenosine 18-25 skull morphology 7 Mus musculus 7-13 9346923-3 1997 There is one binding site for 2"-deoxyadenosine per C1/C2 heterodimer; the Kd is 40 +/- 3 microM. 2'-deoxyadenosine 30-47 heterogeneous nuclear ribonucleoprotein C Homo sapiens 52-57 10226577-1 1999 An L1210 cell line selected for resistance to deoxyadenosine (Y8) has been shown to have barely detectable levels of p53 mRNA and no measurable p53 protein in comparison to the parental mouse wild-type (WT) L1210 cells. 2'-deoxyadenosine 46-60 transformation related protein 53, pseudogene Mus musculus 117-120 9731198-2 1998 Using deoxyadenosine-resistant L1210 cells (ED2 and Y8) that had ribonucleotide reductase that was not sensitive to inhibition by dATP and also exhibited other metabolic alterations, the properties of these cells with respect to the role(s) of nucleotides in these functions were explored. 2'-deoxyadenosine 6-20 unconventional SNARE in the ER 1 homolog (S. cerevisiae) Mus musculus 44-47 9614697-4 1998 Serratia PNP had ten times the affinity for adenosine and deoxyadenosine than for inosine and deoxyinosine in a pattern characteristic of bacterial PNP. 2'-deoxyadenosine 58-72 purine nucleoside phosphorylase Homo sapiens 9-12 9614697-4 1998 Serratia PNP had ten times the affinity for adenosine and deoxyadenosine than for inosine and deoxyinosine in a pattern characteristic of bacterial PNP. 2'-deoxyadenosine 58-72 purine nucleoside phosphorylase Homo sapiens 148-151 9554958-5 1998 The toxic effects of 2"-deoxyadenosine were markedly enhanced by inhibition of adenosine deaminase. 2'-deoxyadenosine 21-38 adenosine deaminase Gallus gallus 79-98 9495239-6 1998 The conversion of 2"-deoxyadenosine to adenine might represent a protective device, emerging when the activity of adenosine deaminase is reduced or inhibited. 2'-deoxyadenosine 18-35 adenosine deaminase Homo sapiens 114-133 9600699-4 1998 These adducts were previously determined to be deoxyadenosine (dA) and deoxyanosine (dG)-derivatives of both anti- and syn-DBP-11,12-diol-13,14-epoxides (DBPDE). 2'-deoxyadenosine 47-61 D-box binding PAR bZIP transcription factor Rattus norvegicus 123-126 9600699-4 1998 These adducts were previously determined to be deoxyadenosine (dA) and deoxyanosine (dG)-derivatives of both anti- and syn-DBP-11,12-diol-13,14-epoxides (DBPDE). 2'-deoxyadenosine 63-65 D-box binding PAR bZIP transcription factor Rattus norvegicus 123-126 9553762-4 1998 Apart from degrading extracellular adenosine (Ado) or 2"-deoxyadenosine (dAdo), which are toxic for lymphocytes, ecto-ADA has an extraenzymatic function via its interaction with CD26. 2'-deoxyadenosine 54-71 adenosine deaminase Homo sapiens 118-121 9553762-4 1998 Apart from degrading extracellular adenosine (Ado) or 2"-deoxyadenosine (dAdo), which are toxic for lymphocytes, ecto-ADA has an extraenzymatic function via its interaction with CD26. 2'-deoxyadenosine 73-77 adenosine deaminase Homo sapiens 118-121 9923554-1 1999 UNLABELLED: 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine (Cl-F-araA) is a novel deoxyadenosine analog, which inhibits DNA synthesis by inhibiting DNA polymerase alpha and ribonucleotide reductase. 2'-deoxyadenosine 97-111 DNA polymerase alpha 1, catalytic subunit Homo sapiens 163-183 9787175-0 1998 Human monocytoid leukemia cells are highly sensitive to apoptosis induced by 2"-deoxycoformycin and 2"-deoxyadenosine: association with dATP-dependent activation of caspase-3. 2'-deoxyadenosine 100-117 caspase 3 Homo sapiens 165-174 9776315-5 1998 Although the purines 2"-deoxyguanosine (dGuo) and 2"-deoxyadenosine are substrates for both dGK and dCK, only CdA among the purine nucleoside analogs tested was an efficient substrate for both dCK and dGK. 2'-deoxyadenosine 50-67 Diacyl glycerol kinase Drosophila melanogaster 92-95 9776315-5 1998 Although the purines 2"-deoxyguanosine (dGuo) and 2"-deoxyadenosine are substrates for both dGK and dCK, only CdA among the purine nucleoside analogs tested was an efficient substrate for both dCK and dGK. 2'-deoxyadenosine 50-67 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 100-103 9461577-3 1998 dCK phosphorylates deoxycytidine, deoxyadenosine, and deoxyguanosine, but not thymidine. 2'-deoxyadenosine 34-48 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 0-3 10223621-3 1998 A deoxyadenosine-resistant L1210 cell line (Y8) derived from the parental WT cells had previously been shown to lack the expression of p53 but to respond to cycloheximide (CHX) treatment by superinduction of p53 mRNA. 2'-deoxyadenosine 2-16 transformation related protein 53, pseudogene Mus musculus 135-138 10223621-3 1998 A deoxyadenosine-resistant L1210 cell line (Y8) derived from the parental WT cells had previously been shown to lack the expression of p53 but to respond to cycloheximide (CHX) treatment by superinduction of p53 mRNA. 2'-deoxyadenosine 2-16 transformation related protein 53, pseudogene Mus musculus 208-211 9361033-4 1997 In general, severity of disease correlates inversely with the amount of residual ADA expressed by the mutant enzymes and directly with the accumulation of the toxic metabolites deoxyATP and deoxyadenosine. 2'-deoxyadenosine 190-204 adenosine deaminase Homo sapiens 81-84 9399998-8 1997 Inhibition of adenosine deaminase by CPC-405 or CPC-406, as well as the 2"-deoxyadenosine toxicity expressed in the presence of these ADA inhibitors, is reversed when the inhibitors are removed by washing the cells. 2'-deoxyadenosine 72-89 adenosine deaminase Rattus norvegicus 134-137 9364008-9 1997 Other major adducts were anti-DB[a,l]PDE-deoxyguanosine and syn-DB[a,l]PDE-deoxyadenosine adducts with minor amounts of syn-DB[a,l]PDE-deoxyguanosine adducts. 2'-deoxyadenosine 75-89 joined toes Mus musculus 60-63 9364008-9 1997 Other major adducts were anti-DB[a,l]PDE-deoxyguanosine and syn-DB[a,l]PDE-deoxyadenosine adducts with minor amounts of syn-DB[a,l]PDE-deoxyguanosine adducts. 2'-deoxyadenosine 75-89 joined toes Mus musculus 120-123 9272950-6 1997 Severe disturbances in purine metabolism were observed in gestation sites lacking decidual ADA, including the accumulation of the potentially toxic ADA substrates adenosine and 2"-deoxyadenosine. 2'-deoxyadenosine 177-194 adenosine deaminase Mus musculus 148-151 9042210-1 1996 L1210 cell lines selected for resistance to deoxyadenosine exhibit altered steady-state levels of the mRNA for the early response genes and p53. 2'-deoxyadenosine 44-58 transformation related protein 53, pseudogene Mus musculus 140-143 9114973-2 1997 Substantial reaction with the amino groups of both deoxyadenosine and deoxyguanosine residues were detected with both the syn and anti derivatives. 2'-deoxyadenosine 51-65 synemin Homo sapiens 122-125 9523470-1 1997 The isoenzymes ADA1 and ADA2 of the enzyme adenosine deaminase (ADA 3.5.4.4) deaminate mainly two nucleotides: adenosine and 2"-deoxyadenosine, molecules with many effects on human cells. 2'-deoxyadenosine 125-142 transcriptional adaptor 1 Homo sapiens 15-19 9523470-1 1997 The isoenzymes ADA1 and ADA2 of the enzyme adenosine deaminase (ADA 3.5.4.4) deaminate mainly two nucleotides: adenosine and 2"-deoxyadenosine, molecules with many effects on human cells. 2'-deoxyadenosine 125-142 transcriptional adaptor 2A Homo sapiens 24-28 9523470-1 1997 The isoenzymes ADA1 and ADA2 of the enzyme adenosine deaminase (ADA 3.5.4.4) deaminate mainly two nucleotides: adenosine and 2"-deoxyadenosine, molecules with many effects on human cells. 2'-deoxyadenosine 125-142 adenosine deaminase Homo sapiens 43-62 9523470-1 1997 The isoenzymes ADA1 and ADA2 of the enzyme adenosine deaminase (ADA 3.5.4.4) deaminate mainly two nucleotides: adenosine and 2"-deoxyadenosine, molecules with many effects on human cells. 2'-deoxyadenosine 125-142 transcriptional adaptor 3 Homo sapiens 64-69 9358225-10 1997 2-DA also improved sperm motion characteristics, though these changes were less uniform with 2-CLA. 2'-deoxyadenosine 0-4 selectin P ligand Homo sapiens 95-98 8962060-8 1996 The dCK homodimer strongly resembles human dCK, with a low K(m) for deoxycytidine, the ability to phosphorylate deoxyadenosine and deoxyguanosine at much higher K(m) values, and end-product inhibition by dCTP. 2'-deoxyadenosine 112-126 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 4-7 8962060-8 1996 The dCK homodimer strongly resembles human dCK, with a low K(m) for deoxycytidine, the ability to phosphorylate deoxyadenosine and deoxyguanosine at much higher K(m) values, and end-product inhibition by dCTP. 2'-deoxyadenosine 112-126 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 43-46 9022297-1 1996 Human lymphocytes lacking adenosine deaminase die and T-cell leukemias are killed by deoxycoformycin (dCf), an inhibitor of adenosine deaminase, due to impaired metabolism of dAdo. 2'-deoxyadenosine 175-179 adenosine deaminase Homo sapiens 124-143 9042210-0 1996 Deoxyadenosine-resistant mouse leukemia L1210 cell lines with alterations in early response genes and p53. 2'-deoxyadenosine 0-14 transformation related protein 53, pseudogene Mus musculus 102-105 9042210-2 1996 In the deoxyadenosine-resistant cell lines (Y8 and ED2), the levels of the mRNAs for p53 and c-jun were markedly decreased while the steady-state levels for mRNAs for c-myc, c-fos and jun B were elevated in the Y-8 and ED2 cell lines. 2'-deoxyadenosine 7-21 unconventional SNARE in the ER 1 homolog (S. cerevisiae) Mus musculus 51-54 9042210-2 1996 In the deoxyadenosine-resistant cell lines (Y8 and ED2), the levels of the mRNAs for p53 and c-jun were markedly decreased while the steady-state levels for mRNAs for c-myc, c-fos and jun B were elevated in the Y-8 and ED2 cell lines. 2'-deoxyadenosine 7-21 transformation related protein 53, pseudogene Mus musculus 85-88 9042210-2 1996 In the deoxyadenosine-resistant cell lines (Y8 and ED2), the levels of the mRNAs for p53 and c-jun were markedly decreased while the steady-state levels for mRNAs for c-myc, c-fos and jun B were elevated in the Y-8 and ED2 cell lines. 2'-deoxyadenosine 7-21 jun proto-oncogene Mus musculus 93-98 9042210-2 1996 In the deoxyadenosine-resistant cell lines (Y8 and ED2), the levels of the mRNAs for p53 and c-jun were markedly decreased while the steady-state levels for mRNAs for c-myc, c-fos and jun B were elevated in the Y-8 and ED2 cell lines. 2'-deoxyadenosine 7-21 FBJ osteosarcoma oncogene Mus musculus 174-179 9042210-2 1996 In the deoxyadenosine-resistant cell lines (Y8 and ED2), the levels of the mRNAs for p53 and c-jun were markedly decreased while the steady-state levels for mRNAs for c-myc, c-fos and jun B were elevated in the Y-8 and ED2 cell lines. 2'-deoxyadenosine 7-21 unconventional SNARE in the ER 1 homolog (S. cerevisiae) Mus musculus 219-222 8828920-6 1996 When E1-2,3-Q was reacted with dG or dA, N2-(2-hydroxyestron-6-yl)deoxyguanosine (2-OHE1-6-N2dG, 10% yield) and N6-(2-hydroxyestron-6-yl)deoxyadenosine (2-OHE1-6-N6dA, 80% yield), respectively, were formed. 2'-deoxyadenosine 37-39 RNA, U105B small nucleolar Homo sapiens 5-9 8764607-1 1996 These experiments characterize the nucleoside transport and quantify the neurotoxicity of adenosine and 2"-deoxyadenosine (dAdo) in chick sympathetic neurons. 2'-deoxyadenosine 104-121 ado Drosophila melanogaster 123-127 8999463-1 1996 2-chlorodeoxyadenosine (2-CdA) is a simple nucleoside derived from deoxyadenosine by substituting chloride for hydrogen in 2" position of the purine ring, which renders it resistant to degradation by adenosine deaminase. 2'-deoxyadenosine 8-22 cytidine deaminase Homo sapiens 26-29 8600457-0 1996 Synthesis and characterization of 8-methoxy-2"- deoxyadenosine-containing oligonucleotides to probe the syn glycosidic conformation of 2"-deoxyadenosine within DNA. 2'-deoxyadenosine 135-152 synemin Homo sapiens 104-107 8962060-1 1996 Three of the four deoxynucleoside kinases required for growth of Lactobacillus acidophilus R-26 exist as heterodimeric pairs specific for deoxyadenosine (dAK) and deoxycytidine (dCK) or dAK and deoxyguanosine (dGK). 2'-deoxyadenosine 138-152 Diacyl glycerol kinase Drosophila melanogaster 210-213 24203484-1 1996 The adducts of phenylglycidyl ether with 2"-deoxyadenosine (dAdo) and 2"-deoxycytidine (dCyd) exhibit structural modifications. 2'-deoxyadenosine 41-58 ado Drosophila melanogaster 60-64 8663040-5 1996 Mice with limited ADA expression exhibited profound disturbances in purine metabolism, including thymus-specific accumulations of deoxyadenosine and dATP, and inhibition of S-adenosylhomocysteine hydrolase in the thymus, spleen, and, to a lesser extent, the liver. 2'-deoxyadenosine 130-144 adenosine deaminase Mus musculus 18-21 8999463-1 1996 2-chlorodeoxyadenosine (2-CdA) is a simple nucleoside derived from deoxyadenosine by substituting chloride for hydrogen in 2" position of the purine ring, which renders it resistant to degradation by adenosine deaminase. 2'-deoxyadenosine 8-22 adenosine deaminase Homo sapiens 200-219 8748457-0 1995 Specific selection of deoxycytidine kinase mutants with tritiated deoxyadenosine. 2'-deoxyadenosine 66-80 deoxycytidine kinase Mus musculus 22-42 8748457-6 1995 The mutant line lacks deoxycytidine kinase that also phosphorylates deoxyadenosine. 2'-deoxyadenosine 68-82 deoxycytidine kinase Mus musculus 22-42 8748457-9 1995 [3H] Deoxyadenosine can be used as a selective agent for specific selection of deoxycytidine kinase-negative mutants. 2'-deoxyadenosine 5-19 deoxycytidine kinase Mus musculus 79-99 17180017-1 1995 The influence of bcl-2 activity on 2"-deoxyadenosine-induced apoptosis was investigated in 697 human pre-B leukemia cells stably transfected with expression plasmid pHeBo-BCL-2alpha (697/BCL2 cells). 2'-deoxyadenosine 35-52 BCL2 apoptosis regulator Homo sapiens 17-22 7629106-3 1995 In support of such a mechanism we show that 2-deoxyadenosine (dAdo) induces apoptosis in chick embryonic sympathetic neurons supported in culture by NGF, excess K+, phorbol 12,13-dibutyrate, or forskolin. 2'-deoxyadenosine 44-60 nerve growth factor Gallus gallus 149-152 7629106-3 1995 In support of such a mechanism we show that 2-deoxyadenosine (dAdo) induces apoptosis in chick embryonic sympathetic neurons supported in culture by NGF, excess K+, phorbol 12,13-dibutyrate, or forskolin. 2'-deoxyadenosine 62-66 nerve growth factor Gallus gallus 149-152 7670465-4 1995 The ADA substrates, adenosine and deoxyadenosine, are increased in ADA-deficient mice. 2'-deoxyadenosine 34-48 adenosine deaminase Mus musculus 4-7 7622293-6 1995 Moreover, the cytotoxic effect was almost completely reversed in the 3 cell lines when inhibitors of adenosine kinase, such as 5"-amino-5"-deoxyadenosine and iodotubercidine, were added to the culture medium together with dCF and dAdo. 2'-deoxyadenosine 230-234 adenosine kinase Homo sapiens 101-117 7622293-9 1995 The AMP and deoxyAMP dephosphorylating activities, much lower in the CHO K-I cells, also appear to play a central role in the toxicity of dAdo when adenosine deaminase is inhibited. 2'-deoxyadenosine 138-142 adenosine deaminase Cricetulus griseus 148-167 7632159-7 1995 The kinetic properties of mouse and human dCK differed in that the human enzyme showed higher affinity for the substrates dAdo, CdA, ddCyd and araG. 2'-deoxyadenosine 122-126 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 42-45 7657748-8 1995 The maximum response for VCL and ALH occurred at 2.5 mM 2"-DEA. 2'-deoxyadenosine 56-62 vinculin Homo sapiens 25-28 7578923-8 1995 The syn orientation at the (AF)G6 places the aminofluorene ring in the B-DNA minor groove in a conformation similar to that found previously when the (AF)G was positioned opposite deoxyadenosine [Norman et al. 2'-deoxyadenosine 180-194 synemin Homo sapiens 4-7 7703358-2 1995 The syn-dihydrodiol epoxide favors reaction with deoxyadenosine (68% of adducts) to a greater extent than does the anti-dihydrodiol epoxide (52% of adducts), and point mutations at AT pairs (72% for syn- and 45% for anti-dihydrodiol epoxide) follow the same trend. 2'-deoxyadenosine 49-63 synemin Homo sapiens 4-7 7703358-2 1995 The syn-dihydrodiol epoxide favors reaction with deoxyadenosine (68% of adducts) to a greater extent than does the anti-dihydrodiol epoxide (52% of adducts), and point mutations at AT pairs (72% for syn- and 45% for anti-dihydrodiol epoxide) follow the same trend. 2'-deoxyadenosine 49-63 synemin Homo sapiens 199-202 17180017-6 1995 Bcl 2 overproduction also suppressed the accumulation of dAMP, dADP and dATP in cells exposed to 2"-deoxyadenosine in the presence of pentostatin to abrogate the pronounced inversion of ATP/dATP pools associated with 2"-deoxyadenosine exposure. 2'-deoxyadenosine 97-114 BCL2 apoptosis regulator Homo sapiens 0-5 17180017-6 1995 Bcl 2 overproduction also suppressed the accumulation of dAMP, dADP and dATP in cells exposed to 2"-deoxyadenosine in the presence of pentostatin to abrogate the pronounced inversion of ATP/dATP pools associated with 2"-deoxyadenosine exposure. 2'-deoxyadenosine 217-234 BCL2 apoptosis regulator Homo sapiens 0-5 17180017-7 1995 These results suggest that one consequence of bcl-2 activity is suppression of 2"-deoxyadenosine phosphorylation and elevation in the apoptotic target cells. 2'-deoxyadenosine 79-96 BCL2 apoptosis regulator Homo sapiens 46-51 7998998-10 1994 Deoxyadenosine (0.1 mM), a P-site inhibitor of adenylate cyclase, blocked bradykinin-stimulated cyclic AMP formation and converted the activation of ERK-2 into a sustained response. 2'-deoxyadenosine 0-14 kininogen 1 Homo sapiens 74-84 7998998-10 1994 Deoxyadenosine (0.1 mM), a P-site inhibitor of adenylate cyclase, blocked bradykinin-stimulated cyclic AMP formation and converted the activation of ERK-2 into a sustained response. 2'-deoxyadenosine 0-14 mitogen-activated protein kinase 1 Homo sapiens 149-154 8056639-6 1994 2"-Deoxyadenosine also increased (P < 0.05) both VSL and VCL at 1.0 mM, and MOT, VSL, VCL, and ALH at 10 mM. 2'-deoxyadenosine 0-17 vinculin Felis catus 60-63 7696543-6 1994 When carried out under oxygen-enriched atmosphere, the reaction of HNE with dAdo yielded 1,N6-ethenodeoxyadenosine (1,N6-EdAdo) and 7-(1",2"-dihydroxyheptyl)-1,N6-EdA in 0.03% and 0.48% yield. 2'-deoxyadenosine 76-80 ectodysplasin A Homo sapiens 121-124 8189039-11 1994 These results document the age-related, tissue-specific expression and localization of ADA in renal tissue, features that probably reflect the crucial role played by the enzyme in adenosine/deoxyadenosine catabolism. 2'-deoxyadenosine 190-204 adenosine deaminase Oryctolagus cuniculus 87-90 7863784-1 1994 The aim of this study was to determine 2-chloro, and 2-bromo derivatives of 2"-deoxyadenosine (2-CdA and 2-BdA respectively) in the serum of human blood by high performance liquid chromatography (HPLC). 2'-deoxyadenosine 76-93 cytidine deaminase Homo sapiens 97-100 9383370-4 1994 RESULTS: Using a novel post-synthetic modification method, 8-azido-2"-deoxyadenosine (N3dA), a photoactive analog of 2"-deoxyadenosine, was introduced at a specific site within a consensus DNA binding site for the NF-kappa B p50 homodimer. 2'-deoxyadenosine 67-84 nuclear factor kappa B subunit 1 Homo sapiens 214-224 9383370-4 1994 RESULTS: Using a novel post-synthetic modification method, 8-azido-2"-deoxyadenosine (N3dA), a photoactive analog of 2"-deoxyadenosine, was introduced at a specific site within a consensus DNA binding site for the NF-kappa B p50 homodimer. 2'-deoxyadenosine 67-84 nuclear factor kappa B subunit 1 Homo sapiens 225-228 7584086-2 1994 The product of the Escherischia coli DeoD gene (purine nucleoside phosphorylase, PNP) differs from the mammalian enzyme in its substrate specificity and is capable of catalyzing the conversion of several non-toxic deoxyadenosine analogs to highly toxic adenine analogs. 2'-deoxyadenosine 214-228 purine nucleoside phosphorylase Homo sapiens 81-84 7584086-3 1994 We have found that expression of E. coli PNP in < 1% of a human colonic carcinoma cell line leads to the death of virtually all bystander cells after treatment with 6-methyl-purine-2"-deoxyribonucleoside, a deoxyadenosine analog that is a substrate for E. coli PNP but not human PNP. 2'-deoxyadenosine 210-224 purine nucleoside phosphorylase Homo sapiens 41-44 7913789-2 1994 The results show that: Thrombin (0.5 U/ml) and ADP (50 mumol/L) stimulate actin polymerization in pig platelets: Adenosine, 5"-chloro-5"-deoxyadenosine, 2"-deoxyadenosine strongly inhibit thrombin- and/or ADP-induced actin polymerization. 2'-deoxyadenosine 153-170 coagulation factor II, thrombin Sus scrofa 23-31 8364152-7 1993 The CONTRA MD method is demonstrated first by application to the simultaneous C2"-endo to C3"-endo repucker and anti to syn N-glycosidic torsion transitions in 2"-deoxyadenosine and then to the large-scale bending in phenylalanine transfer RNA. 2'-deoxyadenosine 160-177 synemin Homo sapiens 120-123 8349799-1 1993 Adenosine deaminase (ADA) deficiency causes severe combined immune deficiency (SCID) by interfering with the metabolism of deoxyadenosine, which is toxic to T lymphocytes at all stages of differentiation. 2'-deoxyadenosine 123-137 adenosine deaminase Homo sapiens 0-19 1463767-0 1992 Deoxyadenosine toxicity in an adenosine deaminase-inhibited human CCRF-CEM T-lymphoblastoid cell line causes cell swelling. 2'-deoxyadenosine 0-14 adenosine deaminase Homo sapiens 30-49 7909479-2 1993 The cause for this is believed to be the accumulation of one of the substrates for ADA, 2"-deoxyadenosine to which especially T cells are hypersensitive. 2'-deoxyadenosine 88-105 adenosine deaminase Homo sapiens 83-86 7909479-6 1993 With this vector we were able to restore human ADA-activity in ADA-SCID T cells to normal levels resulting in a sensitivity to 2"-deoxyadenosine that is also found for T cells from a healthy donor. 2'-deoxyadenosine 127-144 adenosine deaminase Homo sapiens 47-50 7909479-6 1993 With this vector we were able to restore human ADA-activity in ADA-SCID T cells to normal levels resulting in a sensitivity to 2"-deoxyadenosine that is also found for T cells from a healthy donor. 2'-deoxyadenosine 127-144 adenosine deaminase Homo sapiens 63-66 8094002-1 1993 2-Chlorodeoxyadenosine (2-CDA) is an adenosine deaminase resistant analogue of deoxyadenosine which has shown clinical activity in human hematologic neoplasms. 2'-deoxyadenosine 8-22 cytidine deaminase Homo sapiens 26-29 1337428-1 1992 Two enzymes participating in 2"-deoxyadenosine (dAdo) metabolism: dAdo kinase (dAdoK EC 2.7.1.76) and adenosine deaminase (ADA, EC 3.5.4.4) were partially purified from rat liver mitochondria and cytosol and influence of nucleosides and nucleotides on the activity of these enzymes were investigated. 2'-deoxyadenosine 29-46 adenosine deaminase Rattus norvegicus 102-121 1337428-1 1992 Two enzymes participating in 2"-deoxyadenosine (dAdo) metabolism: dAdo kinase (dAdoK EC 2.7.1.76) and adenosine deaminase (ADA, EC 3.5.4.4) were partially purified from rat liver mitochondria and cytosol and influence of nucleosides and nucleotides on the activity of these enzymes were investigated. 2'-deoxyadenosine 29-46 adenosine deaminase Rattus norvegicus 123-126 1337428-1 1992 Two enzymes participating in 2"-deoxyadenosine (dAdo) metabolism: dAdo kinase (dAdoK EC 2.7.1.76) and adenosine deaminase (ADA, EC 3.5.4.4) were partially purified from rat liver mitochondria and cytosol and influence of nucleosides and nucleotides on the activity of these enzymes were investigated. 2'-deoxyadenosine 48-52 adenosine deaminase Rattus norvegicus 102-121 1337428-1 1992 Two enzymes participating in 2"-deoxyadenosine (dAdo) metabolism: dAdo kinase (dAdoK EC 2.7.1.76) and adenosine deaminase (ADA, EC 3.5.4.4) were partially purified from rat liver mitochondria and cytosol and influence of nucleosides and nucleotides on the activity of these enzymes were investigated. 2'-deoxyadenosine 48-52 adenosine deaminase Rattus norvegicus 123-126 1528066-0 1992 Induction of apoptosis in CD4+ prolymphocytic leukemia by deoxyadenosine and 2"-deoxycoformycin. 2'-deoxyadenosine 58-72 CD4 molecule Homo sapiens 26-29 1599494-1 1992 Incorporation of the adenine moiety of 2"-deoxyadenosine (dAdo) into ATP, consistently observed in human erythrocytes, is a phenomenon which cannot be explained by the operation of any known pathway. 2'-deoxyadenosine 39-56 ado Drosophila melanogaster 58-62 1551129-0 1992 Altered steady-state levels of the messenger RNAs for c-myc and p53 in L1210 cell lines resistant to deoxyadenosine. 2'-deoxyadenosine 101-115 transformation related protein 53, pseudogene Mus musculus 64-67 1551129-1 1992 L1210 cell lines, selected for resistance to deoxyadenosine due to the loss of allosteric inhibition of ribonucleotide reductase by dATP, had altered steady-state levels of the mRNAs for c-myc, fos, and p53. 2'-deoxyadenosine 45-59 FBJ osteosarcoma oncogene Mus musculus 194-197 1551129-3 1992 Two different deoxyadenosine-resistant cell lines (Y8 and ED2) had elevated steady-state levels of c-myc and fos but essentially no p53 mRNA. 2'-deoxyadenosine 14-28 FBJ osteosarcoma oncogene Mus musculus 109-112 1528066-1 1992 The leukemic cells of a patient with CD4+ prolymphocytic leukemia were treated in vitro with 5 microM deoxyadenosine and 60 microM 2"-deoxycoformycin (dCF), an inhibitor of adenosine deaminase (ADA). 2'-deoxyadenosine 102-116 CD4 molecule Homo sapiens 37-40 2016760-2 1991 However, when medium containing hydroxyurea and dialyzed serum was supplemented with deoxyadenosine, the block to viral reproduction was circumvented, provided that an inhibitor of adenosine deaminase was also present. 2'-deoxyadenosine 85-99 adenosine deaminase Homo sapiens 181-200 1503644-2 1992 Recent studies (Nair RV, et al., Chem Res Toxicol 4:115-122, 1991) in our laboratory have revealed both deoxyguanosine (dGuo) and deoxyadenosine (dAdo) adducts formed from the anti- and syn-diol epoxides of DB[a,j]A in cultured mouse epidermal cells after exposure to this hydrocarbon. 2'-deoxyadenosine 130-144 joined toes Mus musculus 186-189 1503644-2 1992 Recent studies (Nair RV, et al., Chem Res Toxicol 4:115-122, 1991) in our laboratory have revealed both deoxyguanosine (dGuo) and deoxyadenosine (dAdo) adducts formed from the anti- and syn-diol epoxides of DB[a,j]A in cultured mouse epidermal cells after exposure to this hydrocarbon. 2'-deoxyadenosine 146-150 joined toes Mus musculus 186-189 1731400-7 1992 Levels of adenosine and 2"-deoxyadenosine, which are the endogenous substrates of ADA, were monitored in the embryo/decidual unit (E/D) by reversed-phase high-performance liquid chromatography (RP-HPLC). 2'-deoxyadenosine 24-41 adenosine deaminase Mus musculus 82-85 1441846-3 1992 Km for adenosine and 2"-deoxy-adenosine were 3.08 x 10(-5) M and 3.03 x 10(-5) M for mitochondrial ADA and 3.12 x 10(-5) M and 2.87 x 10(-5) M for cytosolic ADA. 2'-deoxyadenosine 21-39 adenosine deaminase Rattus norvegicus 99-102 1441846-3 1992 Km for adenosine and 2"-deoxy-adenosine were 3.08 x 10(-5) M and 3.03 x 10(-5) M for mitochondrial ADA and 3.12 x 10(-5) M and 2.87 x 10(-5) M for cytosolic ADA. 2'-deoxyadenosine 21-39 adenosine deaminase Rattus norvegicus 157-160 2057348-4 1991 From a detailed examination of its chemical and spectroscopic properties, including comparisons with the model compound N-cyano-N1-(1-methylimidazol-5-yl)formamidine, it is deduced that d(ApA)* contains a deoxyadenosine unit covalently linked through its C(8) position to C(4) of an imidazole N(1) deoxyribonucleoside moiety bearing an N-cyanoformamidino substituent at C(5). 2'-deoxyadenosine 205-219 glutamyl aminopeptidase Homo sapiens 188-191 2163272-0 1990 Selective inactivation of the deoxyadenosine phosphorylating activity of pure human deoxycytidine kinase: stabilization of different forms of the enzyme by substrates and biological detergents. 2'-deoxyadenosine 30-44 deoxycytidine kinase Homo sapiens 84-104 1903326-3 1991 The third major DMBA-derived adduct with deoxyadenosine residues was shown to arise from the (4S,3R)-dihydrodiol through the intermediacy of the syn (4S,3R)-dihydrodiol (2S,1R)-epoxide. 2'-deoxyadenosine 41-55 joined toes Mus musculus 145-148 1995064-0 1991 Deoxyadenosine-resistant human T lymphoblasts with elevated 5"-nucleotidase activity. 2'-deoxyadenosine 0-14 5'-nucleotidase ecto Homo sapiens 60-75 1995064-5 1991 In medium supplemented with the adenosine deaminase inhibitor deoxycoformycin, the T cells with increased 5"-nucleotidase accumulated less nucleotides from exogenously added deoxyadenosine, or 9-beta-D-arabinofuranosyladenine, than did parental T lymphocytes. 2'-deoxyadenosine 174-188 adenosine deaminase Homo sapiens 32-51 1995064-5 1991 In medium supplemented with the adenosine deaminase inhibitor deoxycoformycin, the T cells with increased 5"-nucleotidase accumulated less nucleotides from exogenously added deoxyadenosine, or 9-beta-D-arabinofuranosyladenine, than did parental T lymphocytes. 2'-deoxyadenosine 174-188 5'-nucleotidase ecto Homo sapiens 106-121 2260986-4 1990 The above data are consistent with the metabolism of SAM to ATP by a route recently identified by us whereby ATP is formed from deoxyadenosine: namely binding to the enzyme S-adenosylhomocysteine hydrolase with subsequent release of adenine and further conversion to ATP via APRT. 2'-deoxyadenosine 128-142 adenosylhomocysteinase Homo sapiens 173-205 2260986-4 1990 The above data are consistent with the metabolism of SAM to ATP by a route recently identified by us whereby ATP is formed from deoxyadenosine: namely binding to the enzyme S-adenosylhomocysteine hydrolase with subsequent release of adenine and further conversion to ATP via APRT. 2'-deoxyadenosine 128-142 adenine phosphoribosyltransferase Homo sapiens 275-279 2265250-5 1990 Moreover, anti-Leu-13 potentiated the inhibitory effects of IFN-alpha on BCGF-stimulated DNA synthesis, assessed by [3H]-thymidine and [3H]-deoxyadenosine incorporation into DNA. 2'-deoxyadenosine 140-154 interferon induced transmembrane protein 1 Homo sapiens 15-21 2265250-5 1990 Moreover, anti-Leu-13 potentiated the inhibitory effects of IFN-alpha on BCGF-stimulated DNA synthesis, assessed by [3H]-thymidine and [3H]-deoxyadenosine incorporation into DNA. 2'-deoxyadenosine 140-154 interferon alpha 1 Homo sapiens 60-69 1966469-4 1990 The two digestion procedures exhibit systematic and mostly opposite stereoselectivity in the pattern of which dA adducts are resistant to digestion, which suggest that these adducts may have preferred orientations within modified DNA that are determined by whether they have the R or S configuration at C-1, the point of attachment between the exocyclic amino group of dA and the hydrocarbon; this in turn is dictated by the configuration about the precursor benzylic epoxide carbon and the cis versus trans nature of epoxide opening during adduct formation. 2'-deoxyadenosine 110-112 heterogeneous nuclear ribonucleoprotein C Homo sapiens 303-306 2161685-1 1990 The NMR parameters for the 1,N2-propanodeoxyguanosine (X) opposite deoxyadenosine positioned in the center of the complementary d(C1-A2-T3-G4-X5-G6-T7-A8-C9).d(G10-T11-A12-C13-A14-C15-A 16-T17-G18) X.A 9-mer duplex are pH dependent. 2'-deoxyadenosine 67-81 immunoglobulin kappa variable 2D-19 (pseudogene) Homo sapiens 168-171 2161685-1 1990 The NMR parameters for the 1,N2-propanodeoxyguanosine (X) opposite deoxyadenosine positioned in the center of the complementary d(C1-A2-T3-G4-X5-G6-T7-A8-C9).d(G10-T11-A12-C13-A14-C15-A 16-T17-G18) X.A 9-mer duplex are pH dependent. 2'-deoxyadenosine 67-81 immunoglobulin kappa variable 6D-41 (non-functional) Homo sapiens 176-179 2139230-1 1990 The enzyme adenosine deaminase (ADA) catalyzes the conversion of adenosine and 2"-deoxyadenosine to inosine and 2"-deoxyinosine, respectively. 2'-deoxyadenosine 79-96 adenosine deaminase Mus musculus 11-30 2139230-1 1990 The enzyme adenosine deaminase (ADA) catalyzes the conversion of adenosine and 2"-deoxyadenosine to inosine and 2"-deoxyinosine, respectively. 2'-deoxyadenosine 79-96 adenosine deaminase Mus musculus 32-35 2139230-2 1990 In the absence of ADA activity, 2"-deoxyadenosine is phosphorylated to deoxyadenosine triphosphate. 2'-deoxyadenosine 32-49 adenosine deaminase Mus musculus 18-21 34881804-1 2021 Adenosine deaminase (ADA) is a purine metabolism enzyme that catalyses the breakdown of adenosine and deoxyadenosine. 2'-deoxyadenosine 102-116 adenosine deaminase Homo sapiens 0-19 2156710-2 1990 When deoxyadenosine was added to the inhibited cells, the nucleotide profile was modified reproducing that found in lymphocytes from adenosine deaminase-deficient children. 2'-deoxyadenosine 5-19 adenosine deaminase Homo sapiens 133-152 2369732-4 1990 Six-h incubations with 5, 10, and 20 microM 2"-deoxyadenosine increased dATP pools 4.8-, 8-, and 14.5-fold, respectively, with 59-, 34-, and 43-fold increases in HPRT mutant fractions. 2'-deoxyadenosine 44-61 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 162-166 2326164-4 1990 The structures obtained show a trans-syn cyclobutane linkage and the glycosidic angles are SYN and ANTI for thymidine and deoxyadenosine, respectively. 2'-deoxyadenosine 122-136 synemin Homo sapiens 37-40 2326164-4 1990 The structures obtained show a trans-syn cyclobutane linkage and the glycosidic angles are SYN and ANTI for thymidine and deoxyadenosine, respectively. 2'-deoxyadenosine 122-136 synemin Homo sapiens 91-94 34881804-1 2021 Adenosine deaminase (ADA) is a purine metabolism enzyme that catalyses the breakdown of adenosine and deoxyadenosine. 2'-deoxyadenosine 102-116 adenosine deaminase Homo sapiens 21-24 35358513-1 2022 Deoxyguanosine kinase (dGK) is reported responsible for the phosphorylation of deoxyadenosine (dA) and deoxyguanosine (dG) in the mitochondrial purine salvage pathway. 2'-deoxyadenosine 79-93 deoxyguanosine kinase Rattus norvegicus 0-21 35605980-5 2022 While the existence of m6dA in mammalian DNA remains controversial, we show here that PCIF1 has significant methylation activity on single stranded DNA deoxyadenosine, double stranded RNA/DNA hybrids, and double stranded DNA, though with lower catalytic efficiency than that on its preferred RNA substrate. 2'-deoxyadenosine 152-166 phosphorylated CTD interacting factor 1 Homo sapiens 86-91 35358513-1 2022 Deoxyguanosine kinase (dGK) is reported responsible for the phosphorylation of deoxyadenosine (dA) and deoxyguanosine (dG) in the mitochondrial purine salvage pathway. 2'-deoxyadenosine 79-93 Diacyl glycerol kinase Drosophila melanogaster 23-26 35358513-1 2022 Deoxyguanosine kinase (dGK) is reported responsible for the phosphorylation of deoxyadenosine (dA) and deoxyguanosine (dG) in the mitochondrial purine salvage pathway. 2'-deoxyadenosine 95-97 deoxyguanosine kinase Rattus norvegicus 0-21 35358513-1 2022 Deoxyguanosine kinase (dGK) is reported responsible for the phosphorylation of deoxyadenosine (dA) and deoxyguanosine (dG) in the mitochondrial purine salvage pathway. 2'-deoxyadenosine 95-97 Diacyl glycerol kinase Drosophila melanogaster 23-26 35358513-8 2022 We observed that the kinetics of dA phosphorylation were strikingly different from those of dG phosphorylation, with an exponentially lower affinity for dGK and no effect of dA on dG or ETV phosphorylation. 2'-deoxyadenosine 33-35 Diacyl glycerol kinase Drosophila melanogaster 153-156 35621100-1 2022 Human translational methyltransferase (methylase) HEMK2, whose orthologues are found in many prokaryotes and eukaryotes, methylates such diverse substrates as glutamine and lysine residues in proteins, deoxyadenosine in DNA, and arsenicals. 2'-deoxyadenosine 202-216 N-6 adenine-specific DNA methyltransferase 1 Homo sapiens 50-55 2790329-2 1989 In the presence of deoxyadenosine (dAdo), dCf inhibits T cell function as measured by DNA synthesis induced by stimuli in the rank order of mixed lymphocyte culture greater than murine monoclonal antibody OKT3 greater than phytohemagglutinin. 2'-deoxyadenosine 19-33 ado Drosophila melanogaster 35-39 2623648-1 1989 Adenosine deaminase (ADA) catalyzes the hydrolytic deamination of adenosine (or 2"-deoxyadenosine) to inosine (or 2"-deoxyinosine). 2'-deoxyadenosine 80-97 adenosine deaminase Mus musculus 0-19 2623648-1 1989 Adenosine deaminase (ADA) catalyzes the hydrolytic deamination of adenosine (or 2"-deoxyadenosine) to inosine (or 2"-deoxyinosine). 2'-deoxyadenosine 80-97 adenosine deaminase Mus musculus 21-24 35355997-2 2022 Together with staphylococcal nuclease, AdsA generates deoxyadenosine (dAdo) from neutrophil extracellular DNA traps thereby igniting caspase-3-dependent cell death in host immune cells that aim at penetrating infectious foci. 2'-deoxyadenosine 54-68 ring finger protein 170 Homo sapiens 39-43 35355997-2 2022 Together with staphylococcal nuclease, AdsA generates deoxyadenosine (dAdo) from neutrophil extracellular DNA traps thereby igniting caspase-3-dependent cell death in host immune cells that aim at penetrating infectious foci. 2'-deoxyadenosine 70-74 ring finger protein 170 Homo sapiens 39-43 35355997-3 2022 Powered by a multi-technological approach, we here illustrate that the enzymatic activity of AdsA in abscess-mimicking microenvironments is not restricted to the biogenesis of dAdo but rather comprises excessive biosynthesis of deoxyguanosine (dGuo), a cytotoxic deoxyribonucleoside generated by S. aureus to eradicate macrophages of human and animal origin. 2'-deoxyadenosine 176-180 ring finger protein 170 Homo sapiens 93-97 2473125-7 1989 We subsequently used oligonucleotide-primed DNA amplification to show that C3F arises from a point mutation at codon 1216 converting a deoxyadenosine for a deoxyguanosine. 2'-deoxyadenosine 135-149 lysophosphatidylcholine acyltransferase 3 Homo sapiens 75-78 2789437-8 1989 Back-selection for adenosine deaminase-positive revertants can be accomplished by using a medium containing deoxyadenosine (as a sole source of purine), aminopterin, and thymidine or, alternatively, by using deoxyadenosine alone in a serum-free medium. 2'-deoxyadenosine 108-122 adenosine deaminase Mus musculus 19-38 2789437-8 1989 Back-selection for adenosine deaminase-positive revertants can be accomplished by using a medium containing deoxyadenosine (as a sole source of purine), aminopterin, and thymidine or, alternatively, by using deoxyadenosine alone in a serum-free medium. 2'-deoxyadenosine 208-222 adenosine deaminase Mus musculus 19-38 2775729-4 1989 The large downfield shift of the amino protons of A14 demonstrates protonation of the deoxyadenosine base at pH 5.8 such that the protonated X5(syn).A14(anti) pair is stabilized by two hydrogen bonds at low pH. 2'-deoxyadenosine 86-100 synemin Homo sapiens 144-147 2651461-2 1989 When ADA fails to catalyze the deamination of adenosine and deoxyadenosine, the levels of deoxyadenosine that accumulate are toxic to lymphoid cells. 2'-deoxyadenosine 60-74 adenosine deaminase Homo sapiens 5-8 2497184-7 1989 Analysis of 2"-deoxyadenosine-challenged cells showed that TJF-2 cells accumulated significant levels of deoxyadenosine triphosphate, whereas normal T cells did not unless they were also incubated with the ADA inhibitor deoxycoformycin. 2'-deoxyadenosine 12-29 adenosine deaminase Homo sapiens 206-209 2651461-2 1989 When ADA fails to catalyze the deamination of adenosine and deoxyadenosine, the levels of deoxyadenosine that accumulate are toxic to lymphoid cells. 2'-deoxyadenosine 90-104 adenosine deaminase Homo sapiens 5-8 2539852-5 1989 Deoxyguanosine, deoxyadenosine, and cytidine phosphorylating activities copurified with deoxycytidine kinase to final specific activities of 7.2, 13.5, and 4 mumol min-1 (mg of protein)-1, respectively. 2'-deoxyadenosine 16-30 deoxycytidine kinase Homo sapiens 88-108 2785825-0 1989 ATP formation from deoxyadenosine in human erythrocytes: evidence for a hitherto unidentified route involving adenine and S-adenosylhomocysteine hydrolase. 2'-deoxyadenosine 19-33 adenosylhomocysteinase Homo sapiens 122-154 2785825-2 1989 It entails prior adenine production from deoxyadenosine (or adenosine) in a reaction involving S-adenosylhomocysteine hydrolase. 2'-deoxyadenosine 41-55 adenosylhomocysteinase Homo sapiens 95-127 2539852-5 1989 Deoxyguanosine, deoxyadenosine, and cytidine phosphorylating activities copurified with deoxycytidine kinase to final specific activities of 7.2, 13.5, and 4 mumol min-1 (mg of protein)-1, respectively. 2'-deoxyadenosine 16-30 CD59 molecule (CD59 blood group) Homo sapiens 164-187 2539852-13 1989 Our study indicates that deoxycytidine kinase is a dimer with two subunits and has phosphorylating activity for deoxyguanosine, deoxyadenosine, cytidine, and cytosine arabinoside. 2'-deoxyadenosine 128-142 deoxycytidine kinase Homo sapiens 25-45 2575348-1 1989 Deoxyadenosine is known to be toxic to both proliferating and resting lymphocytes that lack adenosine deaminase (ADA) activity. 2'-deoxyadenosine 0-14 adenosine deaminase Homo sapiens 92-111 2788422-2 1989 Deoxyadenosine metabolism was investigated in rabbit growth plate and articular cartilage to elucidate the biochemical basis for the chondro-osseous dysplasia observed in adenosine deaminase (ADA) deficiency. 2'-deoxyadenosine 0-14 adenosine deaminase Oryctolagus cuniculus 171-190 2788422-2 1989 Deoxyadenosine metabolism was investigated in rabbit growth plate and articular cartilage to elucidate the biochemical basis for the chondro-osseous dysplasia observed in adenosine deaminase (ADA) deficiency. 2'-deoxyadenosine 0-14 adenosine deaminase Oryctolagus cuniculus 192-195 2788422-3 1989 Models of ADA deficiency, the combination of deoxy-adenosine and either of 2 ADA inhibitors, were selectively toxic to immature cartilage, supporting the hypothesis that the chondro-osseous dysplasia of ADA deficiency is the consequence of the enzyme deficiency. 2'-deoxyadenosine 45-60 adenosine deaminase Oryctolagus cuniculus 10-13 2792550-5 1989 The deoxyadenosine/adenosine deamination ratios ranged from 0.75 to 0.84 for both ADA activities. 2'-deoxyadenosine 4-18 adenosine deaminase Gallus gallus 82-85 2792550-7 1989 For erythrocyte ADA, Km values were 8.9-12.9 microM adenosine (range) and 8.3 microM 2"-deoxyadenosine. 2'-deoxyadenosine 85-102 adenosine deaminase Gallus gallus 16-19 2792550-8 1989 For heart ADA, Km values were 6.7-12.0 microM adenosine (range) and 5.3 microM 2"-deoxyadenosine. 2'-deoxyadenosine 79-96 adenosine deaminase Gallus gallus 10-13 2575348-1 1989 Deoxyadenosine is known to be toxic to both proliferating and resting lymphocytes that lack adenosine deaminase (ADA) activity. 2'-deoxyadenosine 0-14 adenosine deaminase Homo sapiens 113-116 3136949-2 1988 With the synthetic syn dihydrodiol epoxide it was possible to identify three of these as deoxyadenosine adducts and to establish their structures. 2'-deoxyadenosine 89-103 joined toes Mus musculus 9-12 3125430-3 1988 The substrate specificity of trypanosomal MeSAdo/Ado phosphorylase differed from that of a mammalian MeSAdo phosphorylase (derived from murine Sarcoma 180 cells) in that it was able to phosphorolyze 2"-deoxyadenosine, 3"-deoxyadenosine and 2",3"-dideoxyadenosine. 2'-deoxyadenosine 199-216 methylthioadenosine phosphorylase Homo sapiens 101-121 2558538-0 1989 Mechanism of ATP catabolism induced by deoxyadenosine and other nucleosides in adenosine deaminase-inhibited human erythrocytes. 2'-deoxyadenosine 39-53 adenosine deaminase Homo sapiens 79-98 3276399-1 1988 Leukemia L1210 cell lines, ED1 and ED2, were generated which were resistant to the cytotoxic effects of deoxyadenosine/erythro-9-(2-hydroxyl-3-nonyl)adenine and deoxyadenosine/erythro-9-(2-hydroxyl-3-nonyl)adenine plus 2,3-dihydro-1H-pyrazole[2,3a]imidazole/Desferal, respectively. 2'-deoxyadenosine 104-118 ectodysplasin-A Mus musculus 27-30 3276399-1 1988 Leukemia L1210 cell lines, ED1 and ED2, were generated which were resistant to the cytotoxic effects of deoxyadenosine/erythro-9-(2-hydroxyl-3-nonyl)adenine and deoxyadenosine/erythro-9-(2-hydroxyl-3-nonyl)adenine plus 2,3-dihydro-1H-pyrazole[2,3a]imidazole/Desferal, respectively. 2'-deoxyadenosine 104-118 unconventional SNARE in the ER 1 homolog (S. cerevisiae) Mus musculus 35-38 3257147-5 1988 The higher concentrations of dCF (with deoxyadenosine) necessary for appreciable growth inhibition could inhibit the increased ADA activity in rIFN-alpha A-treated cells, thus resulting in additive antiproliferative effects. 2'-deoxyadenosine 39-53 adenosine deaminase Homo sapiens 127-130 2835956-7 1987 DEAE chromatography of the wild-type cell extracts revealed two deoxyadenosine phosphorylating activities, one of which coeluted with adenosine kinase and was the enzyme missing in S49-12. 2'-deoxyadenosine 64-78 adenosine kinase Mus musculus 134-150 3109730-7 1987 The three major adducts, tentatively identified as anti-DMBA-3,4-diol-1,2-epoxide (DMBADE):deoxyguanosine, syn-DMBADE:deoxyadenosine and anti-DMBADE:deoxyadenosine, decreased to the same relative extent as the dose of B(e)P increased. 2'-deoxyadenosine 118-132 joined toes Mus musculus 107-110 3109730-7 1987 The three major adducts, tentatively identified as anti-DMBA-3,4-diol-1,2-epoxide (DMBADE):deoxyguanosine, syn-DMBADE:deoxyadenosine and anti-DMBADE:deoxyadenosine, decreased to the same relative extent as the dose of B(e)P increased. 2'-deoxyadenosine 149-163 joined toes Mus musculus 107-110 3807953-6 1987 The activity of S-adenosylhomocysteine hydrolase, which is inactivated by deoxyadenosine, increased to normal in red cells and nucleated marrow cells. 2'-deoxyadenosine 74-88 adenosylhomocysteinase Homo sapiens 16-48 3030413-4 1987 Ado kinase represented a second kinase for dAdo and ara-A while a third kinase for dAdo was found in mitochondria. 2'-deoxyadenosine 43-47 ado Drosophila melanogaster 0-3 3499252-1 1987 2-Bromo-2"-deoxyadenosine (BdA) is one of a group of recently synthesised halogenated deoxyadenosine analogues that are relatively resistant to inactivation by adenosine deaminase (ADA). 2'-deoxyadenosine 11-25 adenosine deaminase Homo sapiens 160-179 3500370-3 1987 The dATP concentrations in HCL, BCL and TCL increased from means of 2.9, 1.8 and 3.0 to 100.3, 68.2 and 51.3 pmol/10(6) cells respectively after 2 h with 10(-5) M dCF and 10(-4)M deoxyadenosine. 2'-deoxyadenosine 179-193 ras homolog family member J Homo sapiens 40-43 3028476-0 1986 S-adenosylhomocysteinase: mechanism of reversible and irreversible inactivation by ATP, cAMP, and 2"-deoxyadenosine. 2'-deoxyadenosine 98-115 adenosylhomocysteinase Rattus norvegicus 0-24 3028476-18 1986 These authors have ascribed the time-dependent inactivation that results from incubation of the enzyme with 2"-deoxyadenosine at the C-3" and concluded that AdoHcyase "probably consists of two nonequivalent pairs of subunits". 2'-deoxyadenosine 108-125 adenosylhomocysteinase Rattus norvegicus 157-166 3489233-4 1986 It is known that ADA-deficient lymphocytes are unusually sensitive to high levels of 2"-deoxyadenosine, and this is the mechanism thought to underlie the selective lymphocytotoxicity associated with ADA deficiency in vivo. 2'-deoxyadenosine 85-102 adenosine deaminase Homo sapiens 17-20 3489233-5 1986 Expression of the introduced ADA gene was sufficient to reverse the hypersensitivity of these genetically deficient lymphocytes to 2"-deoxyadenosine toxicity. 2'-deoxyadenosine 131-148 adenosine deaminase Homo sapiens 29-32 2943306-2 1986 An increase of adenosine deaminase activity (adenosine or deoxyadenosine as substrates) was found in erythrocytes (P less than 0.001) as well as in lymphocytes (P less than 0.001) of Down"s syndrome subjects compared to controls. 2'-deoxyadenosine 58-72 adenosine deaminase Homo sapiens 15-34 3587368-2 1987 Although formation of a benzo[a]pyrene (BaP) diol epoxide-deoxyguanosine adduct has been held responsible for biological activity, the more potent carcinogen, 7,12-dimethylbenz[a]anthracene (DMBA) binds extensively to deoxyadenosine residues in DNA, suggesting that hydrocarbon carcinogen-deoxyadenosine adducts may be instrumental in tumour initiation. 2'-deoxyadenosine 218-232 prohibitin 2 Homo sapiens 40-43 3587368-2 1987 Although formation of a benzo[a]pyrene (BaP) diol epoxide-deoxyguanosine adduct has been held responsible for biological activity, the more potent carcinogen, 7,12-dimethylbenz[a]anthracene (DMBA) binds extensively to deoxyadenosine residues in DNA, suggesting that hydrocarbon carcinogen-deoxyadenosine adducts may be instrumental in tumour initiation. 2'-deoxyadenosine 289-303 prohibitin 2 Homo sapiens 40-43 3492941-1 1986 Adenosine deaminase is a purine salvage enzyme that catalyzes the deamination of adenosine and deoxyadenosine. 2'-deoxyadenosine 95-109 adenosine deaminase Homo sapiens 0-19 3023890-2 1986 The enzyme recognized the sequence GATC and cleaved DNA 5" to the G. Methylation of deoxyadenosine in the GATC sequence inhibited enzyme activity. 2'-deoxyadenosine 84-98 glutamyl-tRNA amidotransferase subunit C Homo sapiens 35-39 3023890-2 1986 The enzyme recognized the sequence GATC and cleaved DNA 5" to the G. Methylation of deoxyadenosine in the GATC sequence inhibited enzyme activity. 2'-deoxyadenosine 84-98 glutamyl-tRNA amidotransferase subunit C Homo sapiens 106-110 2870121-2 1986 When ADA is inactive, deoxyadenosine (dAdo) is phosphorylated by immature T lymphoblasts and inhibits cell division. 2'-deoxyadenosine 22-36 ado Drosophila melanogaster 38-42 3020902-0 1986 Regulation of deoxyadenosine and nucleoside analog phosphorylation by human placental adenosine kinase. 2'-deoxyadenosine 14-28 adenosine kinase Homo sapiens 86-102 3532701-0 1986 Increased level of ribonucleotide reductase in deoxyadenosine resistant adenosine deaminase deficient human histiocytic lymphoma cells. 2'-deoxyadenosine 47-61 adenosine deaminase Homo sapiens 72-91 3935336-6 1985 The Wistar rat embryo cell DNA contained a much larger proportion of the syn-DMBADE-deoxyadenosine adduct. 2'-deoxyadenosine 84-98 joined toes Mus musculus 73-76 2999129-0 1985 Regulation of deoxyadenosine and nucleoside analog phosphorylation by human placental adenosine kinase. 2'-deoxyadenosine 14-28 adenosine kinase Homo sapiens 86-102 2999129-11 1985 These data indicate that deoxyadenosine phosphorylation by adenosine kinase is primarily regulated by its Km and the concentrations of Mg2+, ADP, and AMP. 2'-deoxyadenosine 25-39 adenosine kinase Homo sapiens 59-75 2999129-12 1985 The high Km values for phosphorylation of deoxyadenosine and adenine arabinoside suggest that adenosine kinase may be less likely to phosphorylate these nucleosides in vivo than other enzymes with lower Km values. 2'-deoxyadenosine 42-56 adenosine kinase Homo sapiens 94-110 3917851-10 1985 The major syn-diol-epoxide:deoxy-adenosine adduct was present at a level only 30% that found in high-pressure liquid chromatographic profiles of DMBA samples. 2'-deoxyadenosine 27-42 joined toes Mus musculus 10-13 3874778-2 1985 High levels of deoxyadenosine and deoxyguanosine in patients with inherited deficiency of either adenosine deaminase or purine-nucleoside phosphorylase, respectively, are considered to be responsible for the associated immunological disorder. 2'-deoxyadenosine 15-29 adenosine deaminase Homo sapiens 97-116 3874778-2 1985 High levels of deoxyadenosine and deoxyguanosine in patients with inherited deficiency of either adenosine deaminase or purine-nucleoside phosphorylase, respectively, are considered to be responsible for the associated immunological disorder. 2'-deoxyadenosine 15-29 purine nucleoside phosphorylase Homo sapiens 120-151 3922412-3 1985 Adducts derived from reaction of a syn-dihydrodiol epoxide with deoxyadenosine residues in DNA were the most sensitive to acid and were hydrolyzed to yield a 1,2,3,4-tetrahydrotetraol of 7,12-dimethylbenz[a]anthracene under mild conditions. 2'-deoxyadenosine 64-78 joined toes Mus musculus 35-38 3838797-1 1985 Human adenosine deaminase (ADA) is an important purine catabolic enzyme which irreversibly deaminates adenosine and deoxyadenosine. 2'-deoxyadenosine 116-130 adenosine deaminase Homo sapiens 6-25 3838797-1 1985 Human adenosine deaminase (ADA) is an important purine catabolic enzyme which irreversibly deaminates adenosine and deoxyadenosine. 2'-deoxyadenosine 116-130 adenosine deaminase Homo sapiens 27-30 3838797-2 1985 Severe genetic deficiency of ADA leads to an immunological deficiency state in which T-lymphoid cells are selectively destroyed by the accumulation of toxic levels of deoxyadenosine and deoxy-ATP. 2'-deoxyadenosine 167-181 adenosine deaminase Homo sapiens 29-32 2579098-1 1985 Deoxyadenosine has been implicated as the toxic metabolite causing profound lymphopenia in immunodeficient children with a genetic deficiency of adenosine deaminase (ADA), and in adults treated with the potent ADA inhibitor deoxycoformycin. 2'-deoxyadenosine 0-14 adenosine deaminase Homo sapiens 145-164 2579098-1 1985 Deoxyadenosine has been implicated as the toxic metabolite causing profound lymphopenia in immunodeficient children with a genetic deficiency of adenosine deaminase (ADA), and in adults treated with the potent ADA inhibitor deoxycoformycin. 2'-deoxyadenosine 0-14 adenosine deaminase Homo sapiens 166-169 2579098-1 1985 Deoxyadenosine has been implicated as the toxic metabolite causing profound lymphopenia in immunodeficient children with a genetic deficiency of adenosine deaminase (ADA), and in adults treated with the potent ADA inhibitor deoxycoformycin. 2'-deoxyadenosine 0-14 adenosine deaminase Homo sapiens 210-213 3000695-0 1985 Change in NAD+/NADH content of S-adenosyl-L-homocysteine hydrolase upon NAD+ reversible inactivation by cAMP and 2"-deoxyadenosine. 2'-deoxyadenosine 113-130 adenosylhomocysteinase Homo sapiens 31-66 2986372-6 1985 The residual activity towards deoxyadenosine is considered an intrinsic property of the purified adenosine kinase and, in fact, phosphorylation of adenosine was inhibited competitively by deoxyadenosine, with a Ki of 70 microM. 2'-deoxyadenosine 30-44 adenosine kinase Rattus norvegicus 97-113 2986372-6 1985 The residual activity towards deoxyadenosine is considered an intrinsic property of the purified adenosine kinase and, in fact, phosphorylation of adenosine was inhibited competitively by deoxyadenosine, with a Ki of 70 microM. 2'-deoxyadenosine 188-202 adenosine kinase Rattus norvegicus 97-113 6147383-2 1984 Low activities of the ectoenzymes ecto-5"-nucleotidase and ecto-ATPase have each been associated with deoxyadenosine sensitivity and dATP accumulation in human T-lymphoblasts. 2'-deoxyadenosine 102-116 5'-nucleotidase ecto Homo sapiens 34-54 6330251-3 1984 At low concentrations (less than 25 mumol/L) of deoxyadenosine or ara-adenine, deoxycytidine kinase deficiency decreases growth sensitivity of human T-lymphoblasts to deoxyadenosine approximately fourfold, and to ara-adenine approximately twofold. 2'-deoxyadenosine 48-62 deoxycytidine kinase Homo sapiens 79-99 6330251-3 1984 At low concentrations (less than 25 mumol/L) of deoxyadenosine or ara-adenine, deoxycytidine kinase deficiency decreases growth sensitivity of human T-lymphoblasts to deoxyadenosine approximately fourfold, and to ara-adenine approximately twofold. 2'-deoxyadenosine 167-181 deoxycytidine kinase Homo sapiens 79-99 6330251-5 1984 The inactivation by deoxyadenosine of intracellular S-adenosylhomocysteine hydrolase activity of human adenosine deaminase-deficient B-lymphoblasts and wild-type or deoxycytidine kinase-deficient T-lymphoblasts is comparable, despite the differing toxicity of this compound for these cell lines. 2'-deoxyadenosine 20-34 adenosylhomocysteinase Homo sapiens 52-84 6330251-5 1984 The inactivation by deoxyadenosine of intracellular S-adenosylhomocysteine hydrolase activity of human adenosine deaminase-deficient B-lymphoblasts and wild-type or deoxycytidine kinase-deficient T-lymphoblasts is comparable, despite the differing toxicity of this compound for these cell lines. 2'-deoxyadenosine 20-34 adenosine deaminase Homo sapiens 103-122 6330251-6 1984 Adenosine kinase deficiency in T-lymphoblasts results in resistance to 2"-deoxyadenosine--but not ara-adenine--associated inactivation of S-adenosylhomocysteine hydrolase, and this compound produces comparable degrees of inactivation of S-adenosylhomocysteine hydrolase in both the wild-type and double mutant cells, despite markedly different growth sensitivity. 2'-deoxyadenosine 71-88 adenosylhomocysteinase Homo sapiens 138-170 6330251-7 1984 For B-lymphoblasts, 2"-deoxyadenosine together with adenosine produces comparable growth inhibition of wild-type and adenosine kinase-deficient cells, and this inhibition is more marked than with adenosine alone, but is independent of S-adenosylhomocysteine hydrolase activity. 2'-deoxyadenosine 20-37 adenosine kinase Homo sapiens 117-133 6330251-7 1984 For B-lymphoblasts, 2"-deoxyadenosine together with adenosine produces comparable growth inhibition of wild-type and adenosine kinase-deficient cells, and this inhibition is more marked than with adenosine alone, but is independent of S-adenosylhomocysteine hydrolase activity. 2'-deoxyadenosine 20-37 adenosylhomocysteinase Homo sapiens 235-267 6609265-1 1984 During activation of WF rat splenic T-cells, a change occurs with respect to susceptibility to a toxic accumulation of adenosine or deoxyadenosine (dADO) in the presence of adenosine deaminase (ADA) blockade. 2'-deoxyadenosine 132-146 ado Drosophila melanogaster 148-152 6609265-1 1984 During activation of WF rat splenic T-cells, a change occurs with respect to susceptibility to a toxic accumulation of adenosine or deoxyadenosine (dADO) in the presence of adenosine deaminase (ADA) blockade. 2'-deoxyadenosine 132-146 adenosine deaminase Rattus norvegicus 173-192 3011114-3 1986 In intact cells, the endogenous production of deoxyadenosine from WI-L2 cells deficient in adenosine kinase (EC 2.7.1.20) and deoxycytidine kinase (EC 2.7.1.74) was consistently high, despite changes in endogenous adenosine production. 2'-deoxyadenosine 46-60 adenosine kinase Homo sapiens 91-107 3011114-3 1986 In intact cells, the endogenous production of deoxyadenosine from WI-L2 cells deficient in adenosine kinase (EC 2.7.1.20) and deoxycytidine kinase (EC 2.7.1.74) was consistently high, despite changes in endogenous adenosine production. 2'-deoxyadenosine 46-60 deoxycytidine kinase Homo sapiens 126-146 3011114-4 1986 Endogenous production of deoxyadenosine from CEM cells deficient in adenosine kinase and deoxycytidine kinase was, however, coordinated with endogenous adenosine production. 2'-deoxyadenosine 25-39 adenosine kinase Homo sapiens 68-84 3011114-4 1986 Endogenous production of deoxyadenosine from CEM cells deficient in adenosine kinase and deoxycytidine kinase was, however, coordinated with endogenous adenosine production. 2'-deoxyadenosine 25-39 deoxycytidine kinase Homo sapiens 89-109 3000260-2 1985 Deoxyadenosine is phosphorylated by deoxycytidine kinase, adenosine kinase, and two as yet uncharacterized activities. 2'-deoxyadenosine 0-14 deoxycytidine kinase Homo sapiens 36-56 3000260-2 1985 Deoxyadenosine is phosphorylated by deoxycytidine kinase, adenosine kinase, and two as yet uncharacterized activities. 2'-deoxyadenosine 0-14 adenosine kinase Homo sapiens 58-74 6334686-2 1984 It was found that in the presence of deoxycoformycin, an inhibitor of adenosine deaminase, deoxyadenosine was the only product of deoxy-ATP catabolism. 2'-deoxyadenosine 91-105 adenosine deaminase Homo sapiens 70-89 6236916-1 1984 In the presence of adenosine deaminase (ADA) inhibitors, human T cells are highly sensitive to the cytotoxic action of deoxyadenosine (dAdo). 2'-deoxyadenosine 119-133 adenosine deaminase Homo sapiens 19-38 6236916-1 1984 In the presence of adenosine deaminase (ADA) inhibitors, human T cells are highly sensitive to the cytotoxic action of deoxyadenosine (dAdo). 2'-deoxyadenosine 119-133 adenosine deaminase Homo sapiens 40-43 6236916-1 1984 In the presence of adenosine deaminase (ADA) inhibitors, human T cells are highly sensitive to the cytotoxic action of deoxyadenosine (dAdo). 2'-deoxyadenosine 135-139 adenosine deaminase Homo sapiens 19-38 6236916-1 1984 In the presence of adenosine deaminase (ADA) inhibitors, human T cells are highly sensitive to the cytotoxic action of deoxyadenosine (dAdo). 2'-deoxyadenosine 135-139 adenosine deaminase Homo sapiens 40-43 6091559-10 1984 NAD+-reversible inactivation by cAMP and 2"-deoxyadenosine was also observed with the SAH hydrolase from rabbit erythrocytes. 2'-deoxyadenosine 41-58 acyl-CoA synthetase medium chain family member 3 Homo sapiens 86-89 6610485-2 1984 The addition of deoxyadenosine to ADA-inhibited (but not to uninhibited) cells generated increased dATP pools (up to 50-fold greater than controls) and depressed the mitogen response. 2'-deoxyadenosine 16-30 adenosine deaminase Homo sapiens 34-37 6609529-0 1984 Nucleotide levels and metabolism of adenosine and deoxyadenosine in intact erythrocytes deficient in adenosine deaminase. 2'-deoxyadenosine 50-64 adenosine deaminase Homo sapiens 101-120 6421932-0 1984 Deoxyadenosine (AdR) inhibition of newly activated lymphocytes: blockade at the G0-G1 interface. 2'-deoxyadenosine 0-14 aldo-keto reductase family 1 member B Homo sapiens 16-19 6231047-0 1984 Mechanisms of deoxyadenosine toxicity in human lymphoid cells in vitro: relevance to the therapeutic use of inhibitors of adenosine deaminase. 2'-deoxyadenosine 14-28 adenosine deaminase Homo sapiens 122-141 6231047-1 1984 Deoxyadenosine (AdR) appears to be central to the molecular events mediating immunodeficiency in children born with adenosine deaminase (ADA) deficiency but it is still uncertain whether lymphotoxicity is due to AdR directly inhibiting transmethylation reactions in which S-adenosylmethionine is the methyl group donor, or is due to phosphorylation of AdR to deoxyadenosine triphosphate (dATP) which then inhibits ribonucleotide reductase or is due to other mechanisms. 2'-deoxyadenosine 0-14 adenosine deaminase Homo sapiens 116-135 6603241-3 1983 We have found that non-T, non-B acute lymphoblastic leukemia cells with low ecto-5"-nucleotidase and high adenosine deaminase activities increase their dATP pools by greater than tenfold when exposed to deoxyadenosine and an inhibitor of adenosine deaminase in culture. 2'-deoxyadenosine 203-217 5'-nucleotidase ecto Homo sapiens 76-96 6317046-3 1983 Adenosine kinase (ATP:adenosine 5"-phosphotransferase, EC 2.7.1.20), the first to elute from the column is responsible for the majority of the deoxyadenosine phosphorylation in cell extracts and, according to resistance data, appears to phosphorylate most adenosine analogs tested, including 9-beta-D-arabinosyladenine (ara-A). 2'-deoxyadenosine 143-157 adenosine kinase Cricetulus griseus 0-16 6317046-3 1983 Adenosine kinase (ATP:adenosine 5"-phosphotransferase, EC 2.7.1.20), the first to elute from the column is responsible for the majority of the deoxyadenosine phosphorylation in cell extracts and, according to resistance data, appears to phosphorylate most adenosine analogs tested, including 9-beta-D-arabinosyladenine (ara-A). 2'-deoxyadenosine 143-157 adenosine kinase Cricetulus griseus 22-53 6317046-6 1983 2-Chlorodeoxyadenosine, on the other hand, appeared from resistance data to be phosphorylated, at least in part, by deoxycytidine kinase (ATP:deoxycytidine 5"-phosphotransferase, EC 2.7.1.74), which in cell extracts could also phosphorylate deoxyguanosine and deoxyadenosine, though much less efficiently than deoxycytidine. 2'-deoxyadenosine 8-22 deoxycytidine kinase Cricetulus griseus 116-136 6315214-3 1983 These have been tentatively identified as bay-region anti-dihydrodiol epoxide: deoxyguanosine- and :deoxyadenosine adducts and a bay-region syn-dihydrodiol epoxide:deoxyadenosine-adduct (where the terms syn and anti define dihydrodiol-epoxides wherein the benzylic hydroxyl group and epoxide oxygen are cis or trans to one another, respectively). 2'-deoxyadenosine 164-178 joined toes Mus musculus 140-143 6315214-5 1983 However, the syn-dihydrodiol-epoxide:deoxyadenosine-adduct did increase with dose and constituted as much as 40% of the total DNA binding at high doses of DMBA. 2'-deoxyadenosine 37-51 joined toes Mus musculus 13-16 6420881-8 1983 In PHA-responsive cell fractions (3-6), the sensitivity to inhibition of the PHA response by (deoxy)adenosine and deoxyguanosine was inversely related to the enzyme activity ratio of ecto-5"-nucleotidase to deoxycytidine kinase. 2'-deoxyadenosine 93-109 5'-nucleotidase ecto Homo sapiens 183-203 6420881-8 1983 In PHA-responsive cell fractions (3-6), the sensitivity to inhibition of the PHA response by (deoxy)adenosine and deoxyguanosine was inversely related to the enzyme activity ratio of ecto-5"-nucleotidase to deoxycytidine kinase. 2'-deoxyadenosine 93-109 deoxycytidine kinase Homo sapiens 207-227 6352803-1 1983 The association of a genetic deficiency of adenosine deaminase (ADA) with immunodeficiency disease has emphasized the importance of deoxyadenosine and adenosine metabolism for human lymphocyte function. 2'-deoxyadenosine 132-146 adenosine deaminase Homo sapiens 43-62 6352803-1 1983 The association of a genetic deficiency of adenosine deaminase (ADA) with immunodeficiency disease has emphasized the importance of deoxyadenosine and adenosine metabolism for human lymphocyte function. 2'-deoxyadenosine 132-146 adenosine deaminase Homo sapiens 64-67 6352803-8 1983 In ADA-deficient cells, a major fraction of the deoxyadenosine synthesized de novo was excreted into the extracellular space. 2'-deoxyadenosine 48-62 adenosine deaminase Homo sapiens 3-6 6187447-1 1983 In the presence of the adenosine deaminase inhibitor erythro-9-[3(2-hydroxynonyl)]adenine microM concentrations of 2"-deoxyadenosine (dAdo) are toxic to nondividing human lymphoid cells and induce G1-phase arrest in T-leukemic lymphoblasts, effects which appear to be independent of ribonucleotide reductase inhibition by accumulated 2"-deoxyadenosine 5"-triphosphate. 2'-deoxyadenosine 115-132 adenosine deaminase Homo sapiens 23-42 6187447-1 1983 In the presence of the adenosine deaminase inhibitor erythro-9-[3(2-hydroxynonyl)]adenine microM concentrations of 2"-deoxyadenosine (dAdo) are toxic to nondividing human lymphoid cells and induce G1-phase arrest in T-leukemic lymphoblasts, effects which appear to be independent of ribonucleotide reductase inhibition by accumulated 2"-deoxyadenosine 5"-triphosphate. 2'-deoxyadenosine 115-132 ado Drosophila melanogaster 134-138 6660902-1 1983 Adenosine deaminase, which catalyzes the irreversible hydrolytic deamination of adenosine and deoxyadenosine to inosine and deoxyinosine respectively, plays an important role in the degradation of adenine nucleotide and purine nucleotide salvage pathway metabolism. 2'-deoxyadenosine 94-108 adenosine deaminase Homo sapiens 0-19 6290030-8 1982 The activation of this 5"-nucleotidase by deoxyadenosine 5"-triphosphate, combined with the relative inability of the enzyme to dephosphorylate deoxyadenosine 5"-monophosphate, conceivably may contribute to the adenine nucleotide degradation induced by deoxyadenosine in normal and malignant lymphocytes. 2'-deoxyadenosine 42-56 5'-nucleotidase ecto Homo sapiens 23-38 6958362-2 1982 In each case, it was found that exogenous purines (guanosine, deoxyguanosine, adenosine, deoxyadenosine, and hypoxanthine) both reduced and potentiated MTX cytotoxicity depending on the MTX concentration. 2'-deoxyadenosine 89-103 metaxin 1 Homo sapiens 152-155 6286766-9 1982 The deoxynucleoside kinases (deoxyguanosine, deoxyadenosine, and deoxycytidine kinases) paralleled the changes in ADA and TdT activity among the different T subsets. 2'-deoxyadenosine 45-59 DNA nucleotidylexotransferase Homo sapiens 122-125 6372866-0 1984 Deoxynucleoside overproduction in deoxyadenosine-resistant, adenosine deaminase-deficient human histiocytic lymphoma cells. 2'-deoxyadenosine 34-48 adenosine deaminase Homo sapiens 60-79 6372866-1 1984 Deoxyadenosine toxicity toward lymphocytes may produce immune dysfunction in patients with adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4) deficiency. 2'-deoxyadenosine 0-14 adenosine deaminase Homo sapiens 91-110 6372866-1 1984 Deoxyadenosine toxicity toward lymphocytes may produce immune dysfunction in patients with adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4) deficiency. 2'-deoxyadenosine 0-14 adenosine deaminase Homo sapiens 112-136 6980705-0 1982 S-adenosylhomocysteine hydrolase inhibition in deoxyadenosine-treated human T-lymphoblasts and resting peripheral blood lymphocytes. 2'-deoxyadenosine 47-61 adenosylhomocysteinase Homo sapiens 0-32 6980397-2 1982 We confirm that ADA deficient patients excrete markedly increased amounts of 2"-deoxyadenosine (582 +/- 363 versus normal of less than 0.1 nmoles/mg creatinine) and increased amounts of adenosine (29.4 +/- 5.7 versus normal of 4.12 +/- 1.0 nmoles/mg creatinine). 2'-deoxyadenosine 77-94 adenosine deaminase Homo sapiens 16-19 7079734-3 1982 The activity of S-adenosylhomocysteine hydrolase is dependent in vivo on that of adenosine deaminase, since the substrates for the deaminase, adenosine and deoxyadenosine, respectively, inhibit and inactivate S-adenosylhomocysteine hydrolase in genetic or drug-induced adenosine deaminase deficiency. 2'-deoxyadenosine 156-170 adenosylhomocysteinase Homo sapiens 16-48 7079734-3 1982 The activity of S-adenosylhomocysteine hydrolase is dependent in vivo on that of adenosine deaminase, since the substrates for the deaminase, adenosine and deoxyadenosine, respectively, inhibit and inactivate S-adenosylhomocysteine hydrolase in genetic or drug-induced adenosine deaminase deficiency. 2'-deoxyadenosine 156-170 adenosine deaminase Homo sapiens 81-100 7079734-3 1982 The activity of S-adenosylhomocysteine hydrolase is dependent in vivo on that of adenosine deaminase, since the substrates for the deaminase, adenosine and deoxyadenosine, respectively, inhibit and inactivate S-adenosylhomocysteine hydrolase in genetic or drug-induced adenosine deaminase deficiency. 2'-deoxyadenosine 156-170 adenosylhomocysteinase Homo sapiens 209-241 6980023-10 1982 (ii) When ADA is inhibited or absent, deoxyadenosine is removed rapidly from the circulation by the human erythrocyte utilizing an adenosine transport system linked to both ADA and adenosine kinase (EC 2.7.1.20). 2'-deoxyadenosine 38-52 adenosine deaminase Homo sapiens 10-13 6980023-10 1982 (ii) When ADA is inhibited or absent, deoxyadenosine is removed rapidly from the circulation by the human erythrocyte utilizing an adenosine transport system linked to both ADA and adenosine kinase (EC 2.7.1.20). 2'-deoxyadenosine 38-52 adenosine deaminase Homo sapiens 173-176 6283540-0 1982 Mechanism of deoxyadenosine-induced catabolism of adenine ribonucleotides in adenosine deaminase-inhibited human T lymphoblastoid cells. 2'-deoxyadenosine 13-27 adenosine deaminase Homo sapiens 77-96 6283540-1 1982 Loss of ATP accompanying accumulation of dATP has recently been reported to occur in the erythrocytes and lymphoblasts of patients with T lymphocytic leukemia during treatment with deoxycoformycin, an inhibitor of adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4) that causes the accumulation of deoxyadenosine. 2'-deoxyadenosine 305-319 adenosine deaminase Homo sapiens 214-233 6814540-5 1982 With thymocytes, adenosine deaminase activity was higher with deoxyadenosine than with adenosine. 2'-deoxyadenosine 62-76 adenosine deaminase Rattus norvegicus 17-36 6976204-11 1982 Furthermore, these nondividing peripheral blood lymphocytes were killed by microM concentrations of deoxyadenosine in the presence of an inhibitor of adenosine deaminase. 2'-deoxyadenosine 100-114 adenosine deaminase Homo sapiens 150-169 6256438-1 1981 Deoxyadenosine and its nucleotides have been implicated in the pathogenesis of the immune dysfunction associated with a genetic deficiency of adenosine deaminase (ADA). 2'-deoxyadenosine 0-14 adenosine deaminase Homo sapiens 142-161 6976204-1 1982 Cultured leukemic T-lymphoblasts, incubated in the presence of inhibitors of adenosine deaminase, are exquisitely sensitive to growth inhibition by deoxyadenosine. 2'-deoxyadenosine 148-162 adenosine deaminase Homo sapiens 77-96 6976204-6 1982 Both thymocyte subpopulations elevated in their dATP pools on incubation with microM concentrations of deoxyadenosine in the presence of erythro-9-[3-(2-hydroxynonyl)]adenosine, an inhibitor of adenosine deaminase. 2'-deoxyadenosine 103-117 adenosine deaminase Homo sapiens 194-213 7317429-2 1981 Rates of inward transport of uridine, thymidine, adenosine, 2"-deoxyadenosine, tubercidin, showdomycin, and arabinosyladenine in AE1 cells were less than 1% of those in cells of the parental S49 line. 2'-deoxyadenosine 60-77 solute carrier family 4 (anion exchanger), member 1 Mus musculus 129-132 6272978-7 1981 Further studies of ara-A and deoxyadenosine phosphorylation in wild-type and resistant cell lines disclosed that, although deoxycytidine kinase is the principal enzyme for their phosphorylation in vitro, their intracellular conversion to cytotoxic nucleotides depends on the joint action of deoxycytidine kinase and adenosine kinase rather than purine-specific deoxynucleoside kinase, as previously thought. 2'-deoxyadenosine 29-43 deoxycytidine kinase Homo sapiens 123-143 6976151-1 1981 Adenosine deaminase activity has been measured in red cells from individuals of known ADA phenotype (ADA 1, ADA 2-1, ADA 3-1, ADA 3-2) using adenosine and 2"-deoxyadenosine as substrates. 2'-deoxyadenosine 155-172 adenosine deaminase Homo sapiens 0-19 7238474-2 1981 The 100,000-dalton ADA has a markedly higher Km for adenosine and a markedly lower deaminating activity for deoxyadenosine relative to adenosine than does the 35,000-dalton ADA. 2'-deoxyadenosine 108-122 adenosine deaminase Homo sapiens 19-22 7238474-2 1981 The 100,000-dalton ADA has a markedly higher Km for adenosine and a markedly lower deaminating activity for deoxyadenosine relative to adenosine than does the 35,000-dalton ADA. 2'-deoxyadenosine 108-122 adenosine deaminase Homo sapiens 173-176 7238474-8 1981 Conversely, we report that the human 100,000-dalton ADA isozyme, similar to the avian 100,000-dalton ADA, has markedly lower relative deaminating activity for deoxyadenosine than does the 35,000-dalton ADA human isozyme. 2'-deoxyadenosine 159-173 adenosine deaminase Homo sapiens 52-55 7238474-8 1981 Conversely, we report that the human 100,000-dalton ADA isozyme, similar to the avian 100,000-dalton ADA, has markedly lower relative deaminating activity for deoxyadenosine than does the 35,000-dalton ADA human isozyme. 2'-deoxyadenosine 159-173 adenosine deaminase Homo sapiens 101-104 7238474-8 1981 Conversely, we report that the human 100,000-dalton ADA isozyme, similar to the avian 100,000-dalton ADA, has markedly lower relative deaminating activity for deoxyadenosine than does the 35,000-dalton ADA human isozyme. 2'-deoxyadenosine 159-173 adenosine deaminase Homo sapiens 101-104 6256438-1 1981 Deoxyadenosine and its nucleotides have been implicated in the pathogenesis of the immune dysfunction associated with a genetic deficiency of adenosine deaminase (ADA). 2'-deoxyadenosine 0-14 adenosine deaminase Homo sapiens 163-166 6256438-2 1981 We have previously shown that when ADA is blocked with a synthetic inhibitor, human T lymphoblastoid cell lines are more sensitive to deoxyadenosine toxicity, dephosphorylate deoxyadenosine nucleotides at a slower rate, and have much lower levels of ecto-5"-nucleotidase than most B cell lines. 2'-deoxyadenosine 134-148 adenosine deaminase Homo sapiens 35-38 6967747-2 1980 Inhibition of adenosine deaminase activity resulted in (1) an abrupt rise in plasma deoxyadenosine, but not adenosine, concentrations; (2) accumulation of deoxyadenosine triphosphate by lymphoblasts; (3) inhibition of the enzyme S-adenoylhomocysteine hydrolase; and (4) rapid lysis of the leukemic cells. 2'-deoxyadenosine 84-98 adenosine deaminase Homo sapiens 14-33 6967747-4 1980 Pharmacologic inhibition of adenosine deaminase activity can result in the lysis of T lymphoblasts in vivo, and this effect appears to be mediated by deoxyadenosine. 2'-deoxyadenosine 150-164 adenosine deaminase Homo sapiens 28-47 6254019-0 1980 Resistance of an adenosine kinase-deficient human lymphoblastoid cell line to effects of deoxyadenosine on growth, S-adenosylhomocysteine hydrolase inactivation, and dATP accumulation. 2'-deoxyadenosine 89-103 adenosine kinase Homo sapiens 17-33 6246102-12 1980 S-Adenosylhomocysteine and 2"-deoxyadenosine inhibited adenosine kinase. 2'-deoxyadenosine 27-44 adenosine kinase Homo sapiens 55-71 6247948-4 1980 Deoxyadenosine and deoxyguanosine, substrates that accumulate in ADA and deoxyguanosine, substrates that accumulate in ADA and PNP deficiency, respectively, appear to be selectively phosphorylated by lymphoid cells to the corresponding deoxynucleoside triphosphate, resulting in inhibition of DNA synthesis in these cells. 2'-deoxyadenosine 0-14 adenosine deaminase Homo sapiens 65-68 6247948-4 1980 Deoxyadenosine and deoxyguanosine, substrates that accumulate in ADA and deoxyguanosine, substrates that accumulate in ADA and PNP deficiency, respectively, appear to be selectively phosphorylated by lymphoid cells to the corresponding deoxynucleoside triphosphate, resulting in inhibition of DNA synthesis in these cells. 2'-deoxyadenosine 0-14 adenosine deaminase Homo sapiens 119-122 6965496-0 1980 Plasma deoxyadenosine, adenosine, and erythrocyte deoxyATP are elevated at birth in an adenosine deaminase-deficient child. 2'-deoxyadenosine 7-21 adenosine deaminase Homo sapiens 87-106 115901-4 1979 In the presence of an inhibitor of adenosine deaminase [erythro-9-(2-hydroxy-3-nonyl)adenine [EHNA], 5 muM], deoxyadenosine (1-50 muM) progressively decreased the incorporation of thymidine, uridine, and deoxyuridine into DNA, but did not affect uridine incorporation into RNA. 2'-deoxyadenosine 109-123 latexin Homo sapiens 130-133 499206-9 1979 Complex formation results in changes in the glycosidic torsion angles of both thymidine residues and one deoxyadenosine residue as monitored by chemical shift changes in the thymine C-6 and adenine C-8 protons. 2'-deoxyadenosine 105-119 complement C6 Homo sapiens 182-201 223640-7 1979 A portion of deoxyadenosine is directly phosphorylated to dAMP. 2'-deoxyadenosine 13-27 Amphiphysin Drosophila melanogaster 58-62 312874-1 1979 Micromolar deoxyadenosine inhibits leucine uptake during the 1st day of proliferation in mitogen-stimulated lymphocytes if adenosine deaminase is inhibited. 2'-deoxyadenosine 11-25 adenosine deaminase Homo sapiens 123-142 313967-1 1979 The rate of DNA synthesis in cultured diploid fibroblasts, nonmalignant human cells, is decreased by 50 microM 2"-deoxyadenosine when adenosine deaminase is inhibited and 2"-deoxyadenosine is phosphorylated to dATP. 2'-deoxyadenosine 111-128 adenosine deaminase Homo sapiens 134-153 312296-0 1979 In vivo inactivation of erythrocyte S-adenosylhomocysteine hydrolase by 2"-deoxyadenosine in adenosine deaminase-deficient patients. 2'-deoxyadenosine 72-89 adenosylhomocysteinase Homo sapiens 36-68 312296-2 1979 Earlier studies from this laboratory showed that 2"-deoxyadenosine causes the irreversible inactivation of the enzyme S-adenosylhomocysteine hydrolase by an active site-directed, "suicide-like" process. 2'-deoxyadenosine 49-66 adenosylhomocysteinase Homo sapiens 118-150 312296-4 1979 In vivo suicide-like inactivation of S-adenosylhomocysteine hydrolase by 2"-deoxyadenosine may contribute to the cytotoxicity of 2"-deoxyadenosine and to the immune dysfunction in adenosine deaminase deficiency. 2'-deoxyadenosine 73-90 adenosylhomocysteinase Homo sapiens 37-69 312296-4 1979 In vivo suicide-like inactivation of S-adenosylhomocysteine hydrolase by 2"-deoxyadenosine may contribute to the cytotoxicity of 2"-deoxyadenosine and to the immune dysfunction in adenosine deaminase deficiency. 2'-deoxyadenosine 129-146 adenosylhomocysteinase Homo sapiens 37-69 6254019-1 1980 Accumulation of dATP derived from 2"-deoxyadenosine (dAdo), causing inhibition of ribonucleotide reductase and depletion of the other deoxynucleotide substrates required for DNA synthesis, has been suggested as the cause of the lymphopenia and immune defect in inheritable deficiency of adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4). 2'-deoxyadenosine 34-51 adenosine deaminase Homo sapiens 308-332 6254019-1 1980 Accumulation of dATP derived from 2"-deoxyadenosine (dAdo), causing inhibition of ribonucleotide reductase and depletion of the other deoxynucleotide substrates required for DNA synthesis, has been suggested as the cause of the lymphopenia and immune defect in inheritable deficiency of adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4). 2'-deoxyadenosine 53-57 adenosine deaminase Homo sapiens 308-332 6254019-2 1980 dAdo also inactivates the enzyme S-adenosylhomocysteine hydrolase (AdoHcyase; S-adenosyl-L-homocystein hydrolase EC 3.3.1.1) which is involved in the catabolism of S-adenosyl-L-homocysteine (AdoHcy), both a product and a potent inhibitor of S-adenosylmethionine-dependent transmethylation. 2'-deoxyadenosine 0-4 adenosylhomocysteinase Homo sapiens 33-65 6254019-2 1980 dAdo also inactivates the enzyme S-adenosylhomocysteine hydrolase (AdoHcyase; S-adenosyl-L-homocystein hydrolase EC 3.3.1.1) which is involved in the catabolism of S-adenosyl-L-homocysteine (AdoHcy), both a product and a potent inhibitor of S-adenosylmethionine-dependent transmethylation. 2'-deoxyadenosine 0-4 adenosylhomocysteinase Homo sapiens 67-76 311698-0 1979 Differential inhibition of adenosine deaminase deficient peripheral blood lymphocytes and lymphoid line cells by deoxyadenosine and adenosine. 2'-deoxyadenosine 113-127 adenosine deaminase Homo sapiens 27-46 311477-1 1979 Deoxyadenosine, a cytotoxic purine nucleoside, is excreted in large amounts by patients with severe combined immunodeficiency disease associated with deficiency of adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4). 2'-deoxyadenosine 0-14 adenosine deaminase Homo sapiens 185-209 311477-4 1979 However, in the presence of deoxycoformycin, a potent inhibitor of adenosine deaminase, these macrophages also excreted deoxyadenosine. 2'-deoxyadenosine 120-134 adenosine deaminase Mus musculus 67-86 232631-0 1979 Possible role for 5"-nucleotidase in deoxyadenosine selective toxicity to cultured human lymphoblasts. 2'-deoxyadenosine 37-51 5'-nucleotidase ecto Homo sapiens 18-33 6256765-0 1980 Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo. 2'-deoxyadenosine 42-56 deoxycytidine kinase Homo sapiens 0-20 387357-1 1978 Deoxyadenosine was identified in the urine of a second child with almost undetectable levels of adenosine deaminase (ADA) in erythrocyte lysates. 2'-deoxyadenosine 0-14 adenosine deaminase Homo sapiens 117-120 311004-1 1978 Deoxyadenosine at low concentrations and in the presence of an inhibitor of adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4) is markedly toxic to lymphoblast cell lines of T cell origin but does not impair growth of B cell lines. 2'-deoxyadenosine 0-14 adenosine deaminase Homo sapiens 76-95 311004-1 1978 Deoxyadenosine at low concentrations and in the presence of an inhibitor of adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4) is markedly toxic to lymphoblast cell lines of T cell origin but does not impair growth of B cell lines. 2'-deoxyadenosine 0-14 adenosine deaminase Homo sapiens 97-121 207416-1 1978 Deoxyadenosine but not adenosine reversed the antiviral activity of 9-beta-D-arabinofuranosyladenine (ara-A) and 9-beta-D-arabinofuranosylhypoxanthine (ara-H) when used in the presence of coformycin, an inhibitor of adenosine deaminase. 2'-deoxyadenosine 0-14 adenosine deaminase Homo sapiens 216-235 313053-6 1979 Deoxyadenosine was much less inhibitory, but in the presence of an inhibitor of adenosine deaminase, its effects on lymphocyte growth and function were markedly potentiated. 2'-deoxyadenosine 0-14 adenosine deaminase Homo sapiens 80-99 272665-6 1978 We propose that deoxyadenosine, a substrate of adenosine deaminase, is the potentially toxic substrate in adenosine deaminase deficiency, and that the mediator of the toxic effect is dATP, a recognized potent inhibitor of ribonucleotide reductase. 2'-deoxyadenosine 16-30 adenosine deaminase Homo sapiens 47-66 13641-0 1976 Reversible inhibition of interferon-induced antiviral state by deoxyadenosine. 2'-deoxyadenosine 63-77 interferon Gallus gallus 25-35 13641-1 1976 Deoxyadenosine reversibly inhibited the development of antiviral state (AVS) in chick embryo fibroblasts stimulated by interferon. 2'-deoxyadenosine 0-14 interferon Gallus gallus 119-129 11946352-0 1969 Stimulation of thymidylate kinase and deoxycytidylate deaminase activities of chang cells by deoxyadenosine. 2'-deoxyadenosine 93-107 deoxythymidylate kinase Homo sapiens 15-33 115660-1 1978 The immunodeficient state associated with adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) deficiency may result from the selective phosphorylation by thymus-derived lymphocytes of the ADA substrate deoxyadenosine and the PNP substrate deoxyguanosine, leading to the intracellular trapping of toxic deoxyribonucleoside triphosphates. 2'-deoxyadenosine 218-232 adenosine deaminase Homo sapiens 42-61 115660-1 1978 The immunodeficient state associated with adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) deficiency may result from the selective phosphorylation by thymus-derived lymphocytes of the ADA substrate deoxyadenosine and the PNP substrate deoxyguanosine, leading to the intracellular trapping of toxic deoxyribonucleoside triphosphates. 2'-deoxyadenosine 218-232 purine nucleoside phosphorylase Homo sapiens 72-103 115660-1 1978 The immunodeficient state associated with adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) deficiency may result from the selective phosphorylation by thymus-derived lymphocytes of the ADA substrate deoxyadenosine and the PNP substrate deoxyguanosine, leading to the intracellular trapping of toxic deoxyribonucleoside triphosphates. 2'-deoxyadenosine 218-232 adenosine deaminase Homo sapiens 204-207 115660-1 1978 The immunodeficient state associated with adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) deficiency may result from the selective phosphorylation by thymus-derived lymphocytes of the ADA substrate deoxyadenosine and the PNP substrate deoxyguanosine, leading to the intracellular trapping of toxic deoxyribonucleoside triphosphates. 2'-deoxyadenosine 218-232 purine nucleoside phosphorylase Homo sapiens 105-108 11946352-0 1969 Stimulation of thymidylate kinase and deoxycytidylate deaminase activities of chang cells by deoxyadenosine. 2'-deoxyadenosine 93-107 dCMP deaminase Homo sapiens 38-63