PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 25028129-3 2014 We find linear relationships between these parameters for the deep water (>200 m) of the Japan Sea, suggesting that fluorescent DOM is produced in situ in the Japan Sea. 2,5-Dimethoxy-4-Methylamphetamine 131-134 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 98-101 25172128-9 2014 MMP-1 and LHR gene expression was greater (P < 0.05) for the DOM-D group compared with the DOM-C group. 2,5-Dimethoxy-4-Methylamphetamine 64-67 MMP-1 Equus caballus 0-5 25028129-3 2014 We find linear relationships between these parameters for the deep water (>200 m) of the Japan Sea, suggesting that fluorescent DOM is produced in situ in the Japan Sea. 2,5-Dimethoxy-4-Methylamphetamine 131-134 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 168-171 23726707-7 2013 The presence of DOM (dissolved organic matter) at up to 10 mg/L as TOC had negligible effect on the catalytic activity. 2,5-Dimethoxy-4-Methylamphetamine 16-19 rhomboid 5 homolog 2 Homo sapiens 67-70 8035308-9 1994 These findings suggest that DOM-induced hypophagia and hyperthermia in rats are mediated by stimulation of 5-HT2a receptors. 2,5-Dimethoxy-4-Methylamphetamine 28-31 5-hydroxytryptamine receptor 2A Rattus norvegicus 107-113 20053932-0 2010 Differential effects of serotonin 5-HT1A receptor agonists on the discriminative stimulus effects of the 5-HT2A receptor agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rats and rhesus monkeys. 2,5-Dimethoxy-4-Methylamphetamine 129-176 5-hydroxytryptamine receptor 1A Rattus norvegicus 24-49 18155651-1 2008 The designer drug 2,5-dimethoxy-4-methyl-amphetamine (DOM, STP) is known to be extensively metabolized in various species. 2,5-Dimethoxy-4-Methylamphetamine 18-52 thyroid hormone receptor interactor 10 Rattus norvegicus 59-62 18155651-1 2008 The designer drug 2,5-dimethoxy-4-methyl-amphetamine (DOM, STP) is known to be extensively metabolized in various species. 2,5-Dimethoxy-4-Methylamphetamine 54-57 thyroid hormone receptor interactor 10 Rattus norvegicus 59-62 18155651-5 2008 However, DOM and/or other metabolites such as deamino-oxo-hydroxy DOM might be the target analyte in urine of CYP2D6 poor metabolizers. 2,5-Dimethoxy-4-Methylamphetamine 9-12 cytochrome P450, family 2, subfamily d, polypeptide 4 Rattus norvegicus 110-116 12957227-8 2003 This hypothesis was tested by evaluating (1) the time point at which DOM produces the greatest degree of LSD-appropriate responding, (2) the involvement of 5-HT(2A) receptor in the stimulus effects of DOM at various pretreatment times by administration of M100907 and (3) the ability of 2-DM-DOM and 5-DM-DOM to substitute for the stimulus properties of LSD using either 15- or 75-min pretreatment time. 2,5-Dimethoxy-4-Methylamphetamine 201-204 5-hydroxytryptamine receptor 2A Homo sapiens 156-173 12113827-4 2002 2,6-Dimethoxy-4-methylamphetamine had an approximately 3-fold lower affinity for the 5-HT(2A) receptor compared to the parent 2,5-dimethoxy-4-methylamphetamine (DOM). 2,5-Dimethoxy-4-Methylamphetamine 126-159 5-hydroxytryptamine receptor 2A Homo sapiens 85-102 7965707-6 1994 DOM-induced corticosterone secretion appears to be mediated by stimulation of 5-HT2A and/or 5-HT2C receptors. 2,5-Dimethoxy-4-Methylamphetamine 0-3 5-hydroxytryptamine receptor 2A Rattus norvegicus 78-84 7965707-6 1994 DOM-induced corticosterone secretion appears to be mediated by stimulation of 5-HT2A and/or 5-HT2C receptors. 2,5-Dimethoxy-4-Methylamphetamine 0-3 5-hydroxytryptamine receptor 2C Rattus norvegicus 92-98 21942388-3 2011 The adsorption kinetics of single-walled carbon nanotubes (SWCNTs) was investigated in the presence of DOM as a possible technique for the pretreatment of DBP precursors. 2,5-Dimethoxy-4-Methylamphetamine 103-106 D-box binding PAR bZIP transcription factor Homo sapiens 155-158 15972234-2 2005 The objective of the present study was to determine the neuroanatomical location of the 5HT2A receptors which may be responsible for the stimulus effects of the phenethylamine hallucinogen [-]2,5-dimethoxy-4-methylamphetamine (DOM). 2,5-Dimethoxy-4-Methylamphetamine 192-225 5-hydroxytryptamine receptor 2A Rattus norvegicus 88-93 15972234-2 2005 The objective of the present study was to determine the neuroanatomical location of the 5HT2A receptors which may be responsible for the stimulus effects of the phenethylamine hallucinogen [-]2,5-dimethoxy-4-methylamphetamine (DOM). 2,5-Dimethoxy-4-Methylamphetamine 227-230 5-hydroxytryptamine receptor 2A Rattus norvegicus 88-93 9423935-1 1997 Stimulus control induced by (-)-2,5-dimethoxy-4-methylamphetamine (DOM) is believed to be mediated by agonism at 5-HT2A receptors. 2,5-Dimethoxy-4-Methylamphetamine 28-65 5-hydroxytryptamine receptor 2A Rattus norvegicus 113-119 9423935-1 1997 Stimulus control induced by (-)-2,5-dimethoxy-4-methylamphetamine (DOM) is believed to be mediated by agonism at 5-HT2A receptors. 2,5-Dimethoxy-4-Methylamphetamine 67-70 5-hydroxytryptamine receptor 2A Rattus norvegicus 113-119 7550372-7 1995 This domain consists of a central cluster rich in serine, threonine and proline (STP cluster) flanked by two negatively charged regions containing bulky hydrophobic residues similar to acidic activation domains of Vp1, the herpes simplex virus virion protein VP16 and transcription factors GCN4 and HAP4 from yeast. 2,5-Dimethoxy-4-Methylamphetamine 81-84 regulatory protein viviparous-1 Zea mays 214-217 8355253-0 1993 Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-HT2- versus 5-HT1C-selective antagonist. 2,5-Dimethoxy-4-Methylamphetamine 14-61 5-hydroxytryptamine receptor 2C Rattus norvegicus 109-115 8355253-1 1993 DOM [i.e., 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane] is a 5-HT1C/2 serotonin agonist that exerts stimulus control of behavior in animals. 2,5-Dimethoxy-4-Methylamphetamine 11-58 5-hydroxytryptamine receptor 2C Rattus norvegicus 65-71 34246936-2 2021 Numerous studies chose humic substances as a surrogate of DOM to investigate its influence on Pb(II) immobilization. 2,5-Dimethoxy-4-Methylamphetamine 58-61 submaxillary gland androgen regulated protein 3B Homo sapiens 94-100 34388870-9 2022 The mechanisms of As mobilization/sorption at the solid-water interface can be affected by negatively charged DOM competing for sorption sites with As on Fe (oxy)(hydr)oxides and may be further modified by other anionic ubiquitous species such as phosphate, silicic acid, or sulfur. 2,5-Dimethoxy-4-Methylamphetamine 110-113 general transcription factor IIE subunit 1 Homo sapiens 154-156 34921941-2 2022 However, the effects of DOM on the formation of Fe(III) hydroxysulfate (FHS) and its environmental implications are poorly understood. 2,5-Dimethoxy-4-Methylamphetamine 24-27 general transcription factor IIE subunit 1 Homo sapiens 48-70 34281215-6 2021 In the 24th week, a statistically significant lower 1,25-dihydroxyvitamin D3 level, higher inorganic phosphate level and higher neutrophil gelatinase-associated lipocalin (NGAL) levels in serum were found in the STP group compared to the control. 2,5-Dimethoxy-4-Methylamphetamine 212-215 lipocalin 2 Homo sapiens 128-170 34309260-5 2021 Four humic-like components (C1-C4), comprising terrestrial organic matter (C1, C3, and C4) and microbial degradation products (C2), and two protein-like components (C5 and C6) were identified as the main sources of DOM in the inflow rivers along the Chaohu Lake watershed. 2,5-Dimethoxy-4-Methylamphetamine 215-218 heterogeneous nuclear ribonucleoprotein C Homo sapiens 75-81 34309260-5 2021 Four humic-like components (C1-C4), comprising terrestrial organic matter (C1, C3, and C4) and microbial degradation products (C2), and two protein-like components (C5 and C6) were identified as the main sources of DOM in the inflow rivers along the Chaohu Lake watershed. 2,5-Dimethoxy-4-Methylamphetamine 215-218 complement C5 Homo sapiens 165-174 34281215-6 2021 In the 24th week, a statistically significant lower 1,25-dihydroxyvitamin D3 level, higher inorganic phosphate level and higher neutrophil gelatinase-associated lipocalin (NGAL) levels in serum were found in the STP group compared to the control. 2,5-Dimethoxy-4-Methylamphetamine 212-215 lipocalin 2 Homo sapiens 172-176 35364229-6 2022 DOM induced EndMT and accelerated osteo-induction in HUVECs, which was alleviated by BDNF/tropomyosin receptor kinase B (TrkB) pathway. 2,5-Dimethoxy-4-Methylamphetamine 0-3 brain derived neurotrophic factor Homo sapiens 85-89 35131245-3 2022 The aim of this work was to present the adsorption process of soil DOM by biochar (corn straw biochar produced at 700 C) and to determine whether co-sorption of DOM would change the affinity for Pb(II). 2,5-Dimethoxy-4-Methylamphetamine 67-70 submaxillary gland androgen regulated protein 3B Homo sapiens 196-202 35364229-6 2022 DOM induced EndMT and accelerated osteo-induction in HUVECs, which was alleviated by BDNF/tropomyosin receptor kinase B (TrkB) pathway. 2,5-Dimethoxy-4-Methylamphetamine 0-3 neurotrophic receptor tyrosine kinase 2 Homo sapiens 121-125 35364229-8 2022 BDNF preserved KLF2 and downregulated hexokinase 1 (HK1) in HUVECs after DOM treatment. 2,5-Dimethoxy-4-Methylamphetamine 73-76 Kruppel like factor 2 Homo sapiens 15-19 35364229-8 2022 BDNF preserved KLF2 and downregulated hexokinase 1 (HK1) in HUVECs after DOM treatment. 2,5-Dimethoxy-4-Methylamphetamine 73-76 hexokinase 1 Homo sapiens 38-50 35364229-8 2022 BDNF preserved KLF2 and downregulated hexokinase 1 (HK1) in HUVECs after DOM treatment. 2,5-Dimethoxy-4-Methylamphetamine 73-76 hexokinase 1 Homo sapiens 52-55 35364229-11 2022 HK1 knockdown or a targeted glycolysis inhibitor suppressed EndMT, apoptosis, inflammation and vascular calcification of HUVECs after DOM exposure. 2,5-Dimethoxy-4-Methylamphetamine 134-137 hexokinase 1 Homo sapiens 0-3 35349263-5 2022 For example, the total organic bromine was less than 0.25 muM (as Br) at environmentally relevant bromine radicals" exposures of ~10-9 M s. The results give robust evidence that the scavenging of bromine radicals by DOM is a crucial step to prevent inorganic bromine radical chemistry from producing free bromine (HOBr/OBr-) and subsequent brominated byproducts. 2,5-Dimethoxy-4-Methylamphetamine 216-219 leptin receptor Homo sapiens 319-322 34999315-3 2022 This research investigates the removal of DOM and the minimization of DBP formation by pilot-scale coal- and coconut-based granular activated carbon filtrations (coAC and ccAC, respectively) using unknown screening analysis with Orbitrap mass spectrometry. 2,5-Dimethoxy-4-Methylamphetamine 42-45 phosphopantothenoylcysteine decarboxylase Homo sapiens 162-166 35149433-6 2022 This study suggested that 5-HT2AR coupled both Gs and Gq protein under hallucinogenic agonists DOM and 25CN-NBOH stimulation, but nonhallucinogenic agonist lisuride and TBG only activates Gq signaling. 2,5-Dimethoxy-4-Methylamphetamine 95-98 glutamate-ammonia ligase (glutamine synthetase) Mus musculus 47-49 35347618-2 2022 However, little is known about the difference between DOM from natural and anthropogenic sources for binding Pb(II). 2,5-Dimethoxy-4-Methylamphetamine 54-57 submaxillary gland androgen regulated protein 3B Homo sapiens 109-115 35347618-7 2022 The effluent DOM displayed weak quenching for all fluorescent components (4-6%) and thus weak complexation with Pb(II), indicating notable changes in the chemical composition and metal-binding affinity of DOM by wastewater treatments. 2,5-Dimethoxy-4-Methylamphetamine 205-208 submaxillary gland androgen regulated protein 3B Homo sapiens 112-118 6891802-6 1982 Both DOM and HAL caused prolactin elevation. 2,5-Dimethoxy-4-Methylamphetamine 5-8 prolactin Rattus norvegicus 24-33 7365752-1 1980 Theoretical conformational energy calculations were carried out for the (+) and (-) isomers of the hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM, STP). 2,5-Dimethoxy-4-Methylamphetamine 112-159 thyroid hormone receptor interactor 10 Homo sapiens 166-169 7265116-0 1981 Studies on chiral interactions of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane and the corresponding N-hydroxy metabolites with cytochrome P-450. 2,5-Dimethoxy-4-Methylamphetamine 34-81 cytochrome P-450 Oryctolagus cuniculus 131-147 7265116-1 1981 The stereoselective pharmacological behavior and metabolism of the potent psychotomimetic amine 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane have led to an investigation of the interactions of the racemic amine, its enantiomers, and the corresponding N-hydroxy metabolites with rabbit liver microsomal cytochrome P-450. 2,5-Dimethoxy-4-Methylamphetamine 96-143 cytochrome P-450 Oryctolagus cuniculus 305-321 932131-0 1976 Direct quantitative analysis of lysergic acid diethylamide (LSD) and 2, 5-dimethoxy-4-methylamphetamine (STP) on thin-layer chromatograms. 2,5-Dimethoxy-4-Methylamphetamine 69-103 thyroid hormone receptor interactor 10 Homo sapiens 105-108 989173-2 1976 Pretreatment with methysergide reduced the lethal effects of (+)- and (-)-amphetamine, MDA, PMA and 2, 5-dimethoxy-4-methylamphetamine (STP) suggesting that an action on serotonergic receptors contributed to their toxicity. 2,5-Dimethoxy-4-Methylamphetamine 100-134 sulfotransferase family 1A, phenol-preferring, member 1 Mus musculus 136-139 31658266-4 2019 Here, we identify the Drosophila SWI2/SNF2 protein DOMINO (DOM) as a key regulator of circadian behavior. 2,5-Dimethoxy-4-Methylamphetamine 51-54 swi2 Drosophila melanogaster 33-37 33985732-4 2021 O2 and NO3- could promote the photochemical release of DOM and Fe, especially during the initial 4 h irradiation. 2,5-Dimethoxy-4-Methylamphetamine 55-58 NBL1, DAN family BMP antagonist Homo sapiens 7-10 33985732-5 2021 In general, the order of the photorelease rates of DOM and Fe under different conditions was as follows: NO3-/aerobic > aerobic NO3-/anaerobic > anaerobic. 2,5-Dimethoxy-4-Methylamphetamine 51-54 NBL1, DAN family BMP antagonist Homo sapiens 105-108 33985732-5 2021 In general, the order of the photorelease rates of DOM and Fe under different conditions was as follows: NO3-/aerobic > aerobic NO3-/anaerobic > anaerobic. 2,5-Dimethoxy-4-Methylamphetamine 51-54 NBL1, DAN family BMP antagonist Homo sapiens 130-133 33346661-3 2021 This study aimed at quantifying the reaction rates and the formation of chlorinated organic byproducts produced from Cl and Cl2 - reactions with DOM. 2,5-Dimethoxy-4-Methylamphetamine 146-149 endogenous retrovirus group W member 5 Homo sapiens 125-128 4777246-0 1973 Differentiation of pressor and behavioral effects of d-amphetamine and 2,5-dimethoxy-4-methylamphetamine (STP) by cinanserin. 2,5-Dimethoxy-4-Methylamphetamine 71-104 thyroid hormone receptor interactor 10 Homo sapiens 106-109 4998281-0 1971 The fate of 2,5-dimethoxy-4-methylamphetamine (STP, DOM) in monkey and rat brains. 2,5-Dimethoxy-4-Methylamphetamine 12-45 thyroid hormone receptor interactor 10 Rattus norvegicus 47-50 5769766-1 1969 The hallucinogen 2,5-dimethoxy,-4-methylamphetamine, also known as STP, accumulates in specfic areas of cat brains. 2,5-Dimethoxy-4-Methylamphetamine 17-51 thyroid hormone receptor interactor 10 Homo sapiens 67-70 4860952-0 1967 2,5-dimethoxy-4-methyl-amphetamine (STP): a new hallucinogenic drug. 2,5-Dimethoxy-4-Methylamphetamine 0-34 thyroid hormone receptor interactor 10 Homo sapiens 36-39 4860952-1 1967 We have assessed the effects in normal control volunteers of 2,5-dimethoxy-4-methyl-amphetamine, the chemical present in the hallucinogenic drug STP, in two independent trials. 2,5-Dimethoxy-4-Methylamphetamine 61-95 thyroid hormone receptor interactor 10 Homo sapiens 145-148 32784033-6 2020 The DBP formation potential of DOM draining from a certain area of forest soils (in microg-DBP/m2-soil) was estimated to be reduced by 20.3% for trihalomethanes and increased by 37.5% for haloketones and have minor changes for haloacetonitriles and chloral hydrate (both <7%). 2,5-Dimethoxy-4-Methylamphetamine 31-34 D-box binding PAR bZIP transcription factor Homo sapiens 4-7 32784033-6 2020 The DBP formation potential of DOM draining from a certain area of forest soils (in microg-DBP/m2-soil) was estimated to be reduced by 20.3% for trihalomethanes and increased by 37.5% for haloketones and have minor changes for haloacetonitriles and chloral hydrate (both <7%). 2,5-Dimethoxy-4-Methylamphetamine 31-34 D-box binding PAR bZIP transcription factor Homo sapiens 91-94 32784033-7 2020 Furthermore, the DBPs from chlorination of the soil-derived DOM showed lowered microtoxicity with N addition possibly due to reduced brominated DBP formation. 2,5-Dimethoxy-4-Methylamphetamine 60-63 D-box binding PAR bZIP transcription factor Homo sapiens 17-20 32208217-8 2020 For PAClAl13 which mainly contained Alb, at optimal dose, floc breakage generated the most severe release of DOM and dissolved Al, while the result after re-growth was just reverse. 2,5-Dimethoxy-4-Methylamphetamine 109-112 albumin Homo sapiens 36-39 31658266-4 2019 Here, we identify the Drosophila SWI2/SNF2 protein DOMINO (DOM) as a key regulator of circadian behavior. 2,5-Dimethoxy-4-Methylamphetamine 51-54 brahma Drosophila melanogaster 38-42 31658266-10 2019 Lastly, constitutive activation of PDF-receptor signaling rescued the arrhythmia and period lengthening of DOM downregulation. 2,5-Dimethoxy-4-Methylamphetamine 107-110 Pigment-dispersing factor Drosophila melanogaster 35-38 30031276-4 2018 PC1 was significantly affected by four components of DOM, acetic and tartaric acids that were correlated with the bacteria community shift, especially seven key bacteria. 2,5-Dimethoxy-4-Methylamphetamine 53-56 polycystin 1, transient receptor potential channel interacting Homo sapiens 0-3