PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 30962270-10 2019 Conclusion: Decreased serum levels of 25(OH)D were associated with the occurrence and recurrence of BPPV in a Chinese population, independent of other baseline markers. 25(oh)d 38-45 benign paroxysmal positional vertigo Homo sapiens 100-104 30692241-8 2019 Higher cord blood 25(OH)D levels were associated with lower T1D risk (OR = 0.87 [95% CI 0.77-0.98] per 10 nmol/L increase) in children carrying the VDR rs11568820 G/G genotype (P interaction = 0.01 between 25(OH)D level and rs11568820). 25(oh)d 18-25 vitamin D receptor Homo sapiens 148-151 30975093-8 2019 After adjusting for potential confounders including age, smoking status, drinking status, exercise status, region of residence, seasonality, and parathyroid hormone level, the lowest 25(OH)D quartile group was associated with a higher risk of MetS (odds ratio [OR] 2.25, 95% confidence interval [CI] 1.48-3.43 in men and OR 1.65, 95% CI 1.27-2.16 in women) compared to the highest 25(OH)D quartile group as the reference group. 25(oh)d 183-190 parathyroid hormone Homo sapiens 145-164 30692241-8 2019 Higher cord blood 25(OH)D levels were associated with lower T1D risk (OR = 0.87 [95% CI 0.77-0.98] per 10 nmol/L increase) in children carrying the VDR rs11568820 G/G genotype (P interaction = 0.01 between 25(OH)D level and rs11568820). 25(oh)d 206-213 vitamin D receptor Homo sapiens 148-151 30692241-11 2019 Increased 25(OH)D levels at birth may decrease T1D risk, depending on VDR genotype. 25(oh)d 10-17 vitamin D receptor Homo sapiens 70-73 29450728-5 2019 RESULTS: At baseline, serum 25(OH)D was positively associated with muscle strength, FFMI, and IGFBP-3 in girls only (all p < 0.01). 25(oh)d 28-35 insulin like growth factor binding protein 3 Homo sapiens 94-101 29450728-10 2019 CONCLUSIONS: Avoiding the winter-related decline in serum 25(OH)D may influence IGF-1 and IGFBP-3 in children. 25(oh)d 58-65 insulin like growth factor 1 Homo sapiens 80-85 29450728-10 2019 CONCLUSIONS: Avoiding the winter-related decline in serum 25(OH)D may influence IGF-1 and IGFBP-3 in children. 25(oh)d 58-65 insulin like growth factor binding protein 3 Homo sapiens 90-97 30682545-9 2019 CONCLUSION: We found a strong association between 25(OH)D concentrations and the prognostic indicator CCI and clinical complications (acute respiratory insufficiency, acute liver failure, and infections), but no associations with the prognostic indicators APACHE II and SOFA score, CRP, mechanical ventilation duration, or mortality. 25(oh)d 50-57 C-reactive protein Homo sapiens 282-285 30412765-10 2019 Serum 25(OH)D concentrations were significantly inversely associated with risk of injuries (p = 0.008) and with the concentrations of parathyroid hormone (PTH) (p = 0.029). 25(oh)d 6-13 parathyroid hormone Homo sapiens 134-153 30429108-0 2019 How would serum 25(OH)D level change in patients with inflammatory bowel disease depending on intestinal mucosa vitamin D receptor (VDR) and vitamin D1-alpha hydroxylase (CYP27B1)? 25(oh)d 16-23 vitamin D receptor Homo sapiens 112-130 30429108-0 2019 How would serum 25(OH)D level change in patients with inflammatory bowel disease depending on intestinal mucosa vitamin D receptor (VDR) and vitamin D1-alpha hydroxylase (CYP27B1)? 25(oh)d 16-23 vitamin D receptor Homo sapiens 132-135 30429108-0 2019 How would serum 25(OH)D level change in patients with inflammatory bowel disease depending on intestinal mucosa vitamin D receptor (VDR) and vitamin D1-alpha hydroxylase (CYP27B1)? 25(oh)d 16-23 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 171-178 30646860-9 2019 The HRs of each 1 nmol/L increase in 25(OH)D for albuminuria and impaired eGFR were 0.952(95%CI: 0.941-0.963) and 0.975(95%CI: 0.966-0.983) respectively. 25(oh)d 37-44 epidermal growth factor receptor Homo sapiens 74-78 30774661-2 2019 The purpose of this study was to determine the utility of bioavailable 25(OH)D in assessing vitamin D status when vitamin D-binding protein (VDBP) was significantly altered by pregnancy and liver cirrhosis (LC). 25(oh)d 71-78 GC vitamin D binding protein Homo sapiens 114-139 30774661-2 2019 The purpose of this study was to determine the utility of bioavailable 25(OH)D in assessing vitamin D status when vitamin D-binding protein (VDBP) was significantly altered by pregnancy and liver cirrhosis (LC). 25(oh)d 71-78 GC vitamin D binding protein Homo sapiens 141-145 29153269-12 2018 Interactions between seasons and CYP27A1 rs933994, CYP3A4 rs2246709 on plasma 25(OH)D concentrations were also observed. 25(oh)d 78-85 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 51-57 30588902-7 2019 Pregnant women with 25(OH)D concentrations <75 nmol/l showed lower insulin (beta=-0 12; 95 % CI -0 251, 0 009; P=0 069) and adiponectin (beta=-0 070; 95 % CI -0 150, 0 010; P=0 085) concentrations throughout pregnancy than those with 25(OH)D levels >=75 nmol/l. 25(oh)d 20-27 insulin Homo sapiens 67-74 30588902-7 2019 Pregnant women with 25(OH)D concentrations <75 nmol/l showed lower insulin (beta=-0 12; 95 % CI -0 251, 0 009; P=0 069) and adiponectin (beta=-0 070; 95 % CI -0 150, 0 010; P=0 085) concentrations throughout pregnancy than those with 25(OH)D levels >=75 nmol/l. 25(oh)d 20-27 adiponectin, C1Q and collagen domain containing Homo sapiens 124-135 30588902-8 2019 Pregnant women with 25(OH)D <50 nmol/l at baseline presented significantly higher leptin concentrations than those with 25(OH)D levels >=50 nmol/l (beta=-0 253; 95 % CI -0 044, 0 550; P=0 095). 25(oh)d 20-27 leptin Homo sapiens 82-88 31560030-8 2019 After adjustment for relevant covariates, higher serum 25(OH)D levels were associated with higher score on MMSE-NR (p=0.032) and 10-word Memory Test, immediate recall (p=0.038), as well as faster execution of Trail Making Test A and B (p=0.038 and p=0.021, respectively). 25(oh)d 55-62 TNF superfamily member 10 Homo sapiens 209-214 29153269-8 2018 Variants of NADSYN1/DHCR7 were significantly associated with 25(OH)D concentrations among pregnant women without vitamin D supplements. 25(oh)d 61-68 NAD synthetase 1 Homo sapiens 12-19 31902860-10 2019 Subjects (25(OH)D<20 ng/mL) had a greater proportion of low SMM (55.8%) and low grip strength (66.4%). 25(oh)d 10-17 glutamate receptor interacting protein 1 Homo sapiens 80-84 31902860-11 2019 After adjusting for multiple factors, serum 25(OH)D was positively associated with grip strength (beta=0.18, p=0.009), ASM (beta=0.14, p<0.001), and RSMI (beta=0.07, p<0.001); 25(OH)D<20 ng/mL was significantly associated with low grip strength (OR=2.97, 95% CI: 1.17-7.55), and low SMM (OR=2.73, 95% CI: 1.15-6.45). 25(oh)d 44-51 glutamate receptor interacting protein 1 Homo sapiens 83-87 31902860-11 2019 After adjusting for multiple factors, serum 25(OH)D was positively associated with grip strength (beta=0.18, p=0.009), ASM (beta=0.14, p<0.001), and RSMI (beta=0.07, p<0.001); 25(OH)D<20 ng/mL was significantly associated with low grip strength (OR=2.97, 95% CI: 1.17-7.55), and low SMM (OR=2.73, 95% CI: 1.15-6.45). 25(oh)d 44-51 H19 imprinted maternally expressed transcript Homo sapiens 119-122 31902860-11 2019 After adjusting for multiple factors, serum 25(OH)D was positively associated with grip strength (beta=0.18, p=0.009), ASM (beta=0.14, p<0.001), and RSMI (beta=0.07, p<0.001); 25(OH)D<20 ng/mL was significantly associated with low grip strength (OR=2.97, 95% CI: 1.17-7.55), and low SMM (OR=2.73, 95% CI: 1.15-6.45). 25(oh)d 44-51 glutamate receptor interacting protein 1 Homo sapiens 231-235 30959383-10 2019 CONCLUSIONS: rs7041 and rs4588 variants of the DBP gene are associated with variations in 25(OH)D levels and efficacy of response to vitamin D supplementation in Saudi Arabian adults. 25(oh)d 90-97 D-box binding PAR bZIP transcription factor Homo sapiens 47-50 29153269-8 2018 Variants of NADSYN1/DHCR7 were significantly associated with 25(OH)D concentrations among pregnant women without vitamin D supplements. 25(oh)d 61-68 7-dehydrocholesterol reductase Homo sapiens 20-25 29153269-9 2018 Pregnant women with vitamin D binding protein (Gc) Gc-1f (P = 0.02) and Gc-1s (P = 0.005) had higher plasma 25(OH)D levels compared to women with Gc-2. 25(oh)d 108-115 GC vitamin D binding protein Homo sapiens 20-45 29153269-12 2018 Interactions between seasons and CYP27A1 rs933994, CYP3A4 rs2246709 on plasma 25(OH)D concentrations were also observed. 25(oh)d 78-85 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 33-40 29153269-13 2018 Haplotypes of GC and LRP2 genes shown significant associations with 25(OH)D levels among pregnant women, respectively. 25(oh)d 68-75 LDL receptor related protein 2 Homo sapiens 21-25 29153269-14 2018 CONCLUSIONS: Genetic mutants in vitamin D pathway (GC, CYP3A4, CYP24A1, and NADSYN1/DHCR7) had significant associations with 25(OH)D levels among pregnant women in southeast China. 25(oh)d 125-132 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 55-61 29153269-14 2018 CONCLUSIONS: Genetic mutants in vitamin D pathway (GC, CYP3A4, CYP24A1, and NADSYN1/DHCR7) had significant associations with 25(OH)D levels among pregnant women in southeast China. 25(oh)d 125-132 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 63-70 29153269-14 2018 CONCLUSIONS: Genetic mutants in vitamin D pathway (GC, CYP3A4, CYP24A1, and NADSYN1/DHCR7) had significant associations with 25(OH)D levels among pregnant women in southeast China. 25(oh)d 125-132 NAD synthetase 1 Homo sapiens 76-83 29153269-14 2018 CONCLUSIONS: Genetic mutants in vitamin D pathway (GC, CYP3A4, CYP24A1, and NADSYN1/DHCR7) had significant associations with 25(OH)D levels among pregnant women in southeast China. 25(oh)d 125-132 7-dehydrocholesterol reductase Homo sapiens 84-89 30355032-8 2018 In multivariate analyses, low serum bioavailable 25(OH)D level was significantly associated with increased risks of mortality, independent of established cardiovascular risk factors, features and treatments of CAD, factors associated with vitamin D and mineral metabolism, and CRP (C-reactive protein). 25(oh)d 49-56 C-reactive protein Homo sapiens 277-280 30451913-8 2018 Serum 25(OH)D was negatively associated with osteocalcin, the homeostatic model assessment insulin resistance (HOMA-IR) index, body mass index (BMI), and glycated hemoglobin A1c. 25(oh)d 6-13 bone gamma-carboxyglutamate protein Homo sapiens 45-56 29306481-8 2018 RESULTS: Basal levels of 25(OH)D<=50nmol/L were associated with multivessel coronary artery disease (RR: 2.6 [CI 95%:1.1-7.1], P=.027) and 25(OH)D<=50nmol/L+parathormone >=65pg/mL levels correlated with increased risk for MACE (RR: 4 [CI 95%: 1.1-21.8], P=.04]. 25(oh)d 25-32 thrombopoietin Mus musculus 4-5 29306481-8 2018 RESULTS: Basal levels of 25(OH)D<=50nmol/L were associated with multivessel coronary artery disease (RR: 2.6 [CI 95%:1.1-7.1], P=.027) and 25(OH)D<=50nmol/L+parathormone >=65pg/mL levels correlated with increased risk for MACE (RR: 4 [CI 95%: 1.1-21.8], P=.04]. 25(oh)d 25-32 thrombopoietin Mus musculus 41-42 29306481-8 2018 RESULTS: Basal levels of 25(OH)D<=50nmol/L were associated with multivessel coronary artery disease (RR: 2.6 [CI 95%:1.1-7.1], P=.027) and 25(OH)D<=50nmol/L+parathormone >=65pg/mL levels correlated with increased risk for MACE (RR: 4 [CI 95%: 1.1-21.8], P=.04]. 25(oh)d 25-32 thrombopoietin Mus musculus 177-179 29306481-10 2018 Among patients with 25(OH)D levels<=50nmol/L at the end of the study, 28.6% had MACE versus 0% among patients with 25(OH)D>50nmol/L (RR: 1,4; P=.037). 25(oh)d 20-27 thrombopoietin Mus musculus 43-44 29306481-13 2018 25(OH)D levels<=50nmol/L at the end of the intervention period were significantly associated with an increased number of MACE, hence, 25(OH)D level normalisation could improve cardiovascular health in addition to bone health. 25(oh)d 134-141 thrombopoietin Mus musculus 23-24 30019416-9 2018 CONCLUSION: Serum 25(OH)D level is an independent factor significantly associated with AMH level in women with PCOS but not in ovulatory women. 25(oh)d 18-25 anti-Mullerian hormone Homo sapiens 87-90 30355032-8 2018 In multivariate analyses, low serum bioavailable 25(OH)D level was significantly associated with increased risks of mortality, independent of established cardiovascular risk factors, features and treatments of CAD, factors associated with vitamin D and mineral metabolism, and CRP (C-reactive protein). 25(oh)d 49-56 C-reactive protein Homo sapiens 282-300 30018118-9 2018 Among the examined polymorphisms, DBP1 (rs7041) TT and CDX2 (rs11568820) AA/AG genotypes were markers of better prognosis, even with multivariate adjustment.Conclusions: In patients with NSCLC, vitamin D supplementation may improve survival of patients with early-stage lung adenocarcinoma with lower 25(OH)D levels. 25(oh)d 301-308 DEAH-box helicase 15 Homo sapiens 34-38 30018118-9 2018 Among the examined polymorphisms, DBP1 (rs7041) TT and CDX2 (rs11568820) AA/AG genotypes were markers of better prognosis, even with multivariate adjustment.Conclusions: In patients with NSCLC, vitamin D supplementation may improve survival of patients with early-stage lung adenocarcinoma with lower 25(OH)D levels. 25(oh)d 301-308 caudal type homeobox 2 Homo sapiens 55-59 29478008-9 2018 Peak GH was a significant predictor of 25(OH)D levels. 25(oh)d 39-46 growth hormone 1 Homo sapiens 5-7 29555202-0 2018 Association of vitamin D receptor gene polymorphisms with serum 25(OH)D levels and metabolic syndrome in Thai population. 25(oh)d 64-71 vitamin D receptor Homo sapiens 15-33 29555202-3 2018 The aim of this study was to investigate the relationship between the VDR polymorphisms and MetS, metabolic components, and serum 25(OH)D levels within the Thai population. 25(oh)d 130-137 vitamin D receptor Homo sapiens 70-73 29186386-8 2018 Furthermore, chemical inhibitor and RNA inference analysis demonstrated that cubilin was involved in 25(OH)D uptake by adipocytes. 25(oh)d 101-108 cubilin (intrinsic factor-cobalamin receptor) Mus musculus 77-84 29571607-10 2018 Serum 25(OH)D concentration was significantly and negatively correlated with serum IL-6. 25(oh)d 6-13 interleukin 6 Homo sapiens 83-87 28732679-4 2018 We hypothesized that 25(OH)D concentrations would be negatively associated with NFkappaB activity and pro-inflammatory markers downstream of NFkappaB, and positively associated with anti-inflammatory markers. 25(oh)d 21-28 nuclear factor kappa B subunit 1 Homo sapiens 80-88 28732679-4 2018 We hypothesized that 25(OH)D concentrations would be negatively associated with NFkappaB activity and pro-inflammatory markers downstream of NFkappaB, and positively associated with anti-inflammatory markers. 25(oh)d 21-28 nuclear factor kappa B subunit 1 Homo sapiens 141-149 29461603-12 2018 Correlation analysis revealed that 25(OH)D was positively correlated with HDL and NO, but negatively correlated with TG, TC, TNF-alpha, and vWF. 25(oh)d 35-42 tumor necrosis factor Homo sapiens 125-134 29461603-12 2018 Correlation analysis revealed that 25(OH)D was positively correlated with HDL and NO, but negatively correlated with TG, TC, TNF-alpha, and vWF. 25(oh)d 35-42 von Willebrand factor Homo sapiens 140-143 29897564-8 2018 Notably, a pooled analysis indicated that changes in serum 25(OH)D were positively associated with changes in serum BALP, PINP, and TRAP5b (r = 0.07-0.16, P <= 0.02), but inversely with changes in PTH (r = -0.15, P < 0.001). 25(oh)d 59-66 parathyroid hormone Homo sapiens 197-200 29892562-13 2018 Conclusion: While serum 25(OH)D levels in obese AA teens increased adequately with vitamin treatment for 12 weeks and correlated with fasting insulin, it did not significantly impact insulin secretion or sensitivity. 25(oh)d 24-31 insulin Homo sapiens 142-149 29320465-6 2018 CRP concentrations were higher in individuals with lower 25(OH)D concentrations. 25(oh)d 57-64 C-reactive protein Homo sapiens 0-3 27629594-11 2018 We found correlation between leptin and serum 25(OH)D level (r=-0.15, p=0.01) but this finding was a characteristic seen only in women. 25(oh)d 46-53 leptin Homo sapiens 29-35 28830874-7 2017 Five other VDR SNPs showed evidence of interaction at P < 0.05, as did one SNP in CYP2R1 and one in RXRA As a group, the 82 SNPs showed evidence of multiplicative interaction with 25(OH)D (P = 0.04). 25(oh)d 183-190 vitamin D receptor Homo sapiens 11-14 32476896-11 2018 An inverse correlation between ACE and 25(OH)D levels was found (p=0.052). 25(oh)d 39-46 angiotensin I converting enzyme Homo sapiens 31-34 28616825-8 2017 Moreover, serum 25(OH)D levels inversely correlated with insulin levels (P = 0.0001) and intima-media thickness (P = 0.015), and directly with serum HDL cholesterol (P = 0.010). 25(oh)d 16-23 insulin Homo sapiens 57-64 27473561-1 2017 CYP2R1 is the principal hepatic 25-hydroxylase responsible for the hydroxylation of parent vitamin D to 25-hydroxyvitamin D [25(OH)D]. 25(oh)d 125-132 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 0-6 28555324-4 2017 Among risk factors recognized, deficiency in 25-hydroxyvitamin D [25(OH)D], already acknowledged as involved in calcium homeostasis, pathogenesis of cardiovascular, oncological, infective and immunity diseases, could predispose to the development of both type 1 and 2 diabetes, modifying the activity of pancreatic beta-cells vitamin D (VD) receptor. 25(oh)d 66-73 vitamin D receptor Homo sapiens 326-349 27473561-3 2017 The 1alpha-hydroxylation of 25(OH)D in the kidney by CYP27B1 generates the fully active vitamin D metabolite, 1,25-dihydroxyvitamin D (1,25(OH)2D). 25(oh)d 28-35 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 53-60 28403948-12 2017 CONCLUSIONS: Inadequate plasma 25(OH)D concentrations during early pregnancy were associated with more pronounced changes of TC, LDL-c concentrations, and TC/HDL-c ratios throughout pregnancy. 25(oh)d 31-38 component of oligomeric golgi complex 2 Homo sapiens 129-134 27307256-13 2017 PTH increased subsequently, which coincide with the decreased 25(OH)D levels. 25(oh)d 62-69 parathyroid hormone Homo sapiens 0-3 28937066-12 2017 Insulin-resistance in non-diabetic CKD was correlated with 25(OH)D levels. 25(oh)d 59-66 insulin Homo sapiens 0-7 28437713-2 2017 The measurement of serum 24,25(OH)2D concentration may serve as an indicator of vitamin D catabolic status and the relative ratio with 25(OH)D can be used to identify patients with inactivating mutations in CYP24A1. 25(oh)d 135-142 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 207-214 28095044-4 2017 The majority of circulating 25(OH)D and 1,25-dihydroxyvitamin D is tightly bound to DBP and albumin, with less than 1% circulating in an unbound form. 25(oh)d 28-35 D-box binding PAR bZIP transcription factor Homo sapiens 84-87 26997468-8 2016 RESULTS: Serum 25(OH)D levels before treatment were statistically lower in PCOS women than in NOR patients (P<0.05), even after adjustment for BMI, age and AMH level, but not after adjustment for waist circumference measurement. 25(oh)d 15-22 anti-Mullerian hormone Homo sapiens 159-162 27919752-1 2017 Total 25(OH)D levels were determined to assess bone health in elderly populations; however, the bioavailability of 25(OH)D is regulated by the albumin and vitamin D binding protein (DBP) levels and DBP variations. 25(oh)d 115-122 GC vitamin D binding protein Homo sapiens 155-180 27919752-1 2017 Total 25(OH)D levels were determined to assess bone health in elderly populations; however, the bioavailability of 25(OH)D is regulated by the albumin and vitamin D binding protein (DBP) levels and DBP variations. 25(oh)d 115-122 D-box binding PAR bZIP transcription factor Homo sapiens 182-185 27919752-1 2017 Total 25(OH)D levels were determined to assess bone health in elderly populations; however, the bioavailability of 25(OH)D is regulated by the albumin and vitamin D binding protein (DBP) levels and DBP variations. 25(oh)d 115-122 D-box binding PAR bZIP transcription factor Homo sapiens 198-201 27682437-6 2017 Carriage of the minor VDR allele was associated with lower 25(OH)D concentration in participants with the least sunlight exposure. 25(oh)d 59-66 vitamin D receptor Homo sapiens 22-25 27473187-12 2017 CONCLUSION: This study showed a difference in 25(OH)D levels between CYP2R1 genotypes that equates a daily supplementation of 400-800 IU vitamin D, depending on genotype. 25(oh)d 46-53 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 69-75 28245892-9 2017 The 9 % of children who reported taking vitamin D-containing supplements in the previous month had higher 25(OH)D concentrations (OR 6 9 nmol/l; 95 % CI 1 1, 12 7 nmol/l) relative to those who did not. 25(oh)d 106-113 olfactory receptor family 2 subfamily J member 4 pseudogene Homo sapiens 130-136 27819306-7 2016 Furthermore, serum 25(OH)D levels inversely correlated with several systemic inflammatory markers, e.g. serum C reactive protein, but did not associate with prognosis. 25(oh)d 19-26 C-reactive protein Homo sapiens 110-128 27529229-4 2016 25(OH)D is biologically inert and needs hydroxylation by CYP27B1 to form 1alpha,25(OH)2D3, which is originally believed to only take place in kidneys. 25(oh)d 0-7 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 57-64 27865354-4 2016 We hypothesized that increased 25(OH)D concentration after vitamin D supplementation for 1 year would significantly improve insulin resistance. 25(oh)d 31-38 insulin Homo sapiens 124-131 27155524-11 2016 This is the first clinical study evaluating the association between serum 25(OH)D levels and VDR polymorphisms in children with ASD. 25(oh)d 74-81 vitamin D receptor Homo sapiens 93-96 26991691-9 2016 CONCLUSION: Results from these nationally representative studies support a positive association between serum 25(OH)D and testosterone and SHBG. 25(oh)d 110-117 sex hormone binding globulin Homo sapiens 139-143 27231162-13 2016 Serum PTH concentration was negatively correlated with 25(OH)D concentration (r = -0.163, P < 0.05). 25(oh)d 55-62 parathyroid hormone Homo sapiens 6-9 26547217-1 2016 Free 25-hydroxyvitamin D [25(OH)D] is suggested to be important in the determination of vitamin D deficiency, since vitamin D-binding protein (VDBP) may affect total 25(OH)D levels. 25(oh)d 166-173 GC vitamin D binding protein Homo sapiens 116-141 26547217-1 2016 Free 25-hydroxyvitamin D [25(OH)D] is suggested to be important in the determination of vitamin D deficiency, since vitamin D-binding protein (VDBP) may affect total 25(OH)D levels. 25(oh)d 166-173 GC vitamin D binding protein Homo sapiens 143-147 26513524-3 2016 We investigated the association of VDR polymorphisms and 25(OH)D levels in Chinese patients with Crohn"s disease (CD). 25(oh)d 57-64 vitamin D receptor Homo sapiens 35-38 27032111-13 2016 The patients with optimal vitamin D status [25(OH)D >=75 nmol/l] had lower plasma levels of CCL7 (P = 0.047) and basic fibroblast growth factor (P = 0.042). 25(oh)d 44-51 C-C motif chemokine ligand 7 Homo sapiens 95-99 27314039-1 2016 The aim of the present study is (1) to determine the correlation between circulating 1,25-dihydroxyvitamin D [25(OH)D] and adiponectin, nonesterified fatty acids (NEFAs), and glycerol and (2) to determine the alterations in circulating endothelial microparticles (EMPs) in Chinese male subjects with increased body mass index (BMI). 25(oh)d 110-117 adiponectin, C1Q and collagen domain containing Homo sapiens 123-134 26209260-13 2016 CONCLUSION: Serum 25(OH)D levels were positively associated with total IgE levels. 25(oh)d 18-25 immunoglobulin heavy constant epsilon Homo sapiens 71-74 27314039-6 2016 In Chinese male adults with varied BMI, an inverse correlation existed between 25(OH)D levels and total adiponectin, NEFA, and glycerol levels; and there is no significant difference for CD62E+ or CD31+/CD42b- EMPs among lean, overweight, and obese subjects. 25(oh)d 79-86 adiponectin, C1Q and collagen domain containing Homo sapiens 104-115 25618772-3 2016 Filtered 25(OH)D bound to vitamin D binding protein (DBP) is endocytosed by megalin-cubilin in the apical membrane. 25(oh)d 9-16 GC vitamin D binding protein Homo sapiens 26-51 25618772-3 2016 Filtered 25(OH)D bound to vitamin D binding protein (DBP) is endocytosed by megalin-cubilin in the apical membrane. 25(oh)d 9-16 LDL receptor related protein 2 Homo sapiens 76-83 25618772-3 2016 Filtered 25(OH)D bound to vitamin D binding protein (DBP) is endocytosed by megalin-cubilin in the apical membrane. 25(oh)d 9-16 D-box binding PAR bZIP transcription factor Homo sapiens 53-56 26637501-13 2015 CONCLUSION: The majority (85.3%) of the Greek Caucasian patients with HT studied who lived and worked in Crete had low serum 25(OH)D levels inversely correlated with serum anti-TPO thyroid antibodies. 25(oh)d 125-132 thyroid peroxidase Homo sapiens 177-180 25618772-3 2016 Filtered 25(OH)D bound to vitamin D binding protein (DBP) is endocytosed by megalin-cubilin in the apical membrane. 25(oh)d 9-16 cubilin Homo sapiens 84-91 26446485-1 2015 BACKGROUND: Research indicates that plasma 25-hydroxyvitamin D [25(OH)D] is associated with insulin resistance, but whether regional adiposity confounds this association is unclear. 25(oh)d 64-71 insulin Homo sapiens 92-99 26356094-12 2015 CONCLUSIONS: Physiologic deficiency of 25(OH)D in critical illness may be more difficult to diagnose, given that lower VDBP levels increase bioavailability. 25(oh)d 39-46 GC vitamin D binding protein Homo sapiens 119-123 26177638-2 2015 We aimed to investigate the relationship between 25(OH)D levels and total and free testosterone (T), sex hormone binding globulin (SHBG), estradiol, and hypogonadism in Chinese men. 25(oh)d 49-56 sex hormone binding globulin Homo sapiens 101-129 26025591-8 2015 The presence of vitamin D receptor (VDR) and the enzyme responsible for conversion of the 25(OH)D in its active metabolite 25(OH)2D3 in extra renal tissue shows the involvement of vitamin D in other diseases like cancer, diabetes, multiple sclerosis etc. 25(oh)d 90-97 vitamin D receptor Homo sapiens 16-34 26025591-8 2015 The presence of vitamin D receptor (VDR) and the enzyme responsible for conversion of the 25(OH)D in its active metabolite 25(OH)2D3 in extra renal tissue shows the involvement of vitamin D in other diseases like cancer, diabetes, multiple sclerosis etc. 25(oh)d 90-97 vitamin D receptor Homo sapiens 36-39 25656524-8 2015 An increase in 25(OH)D levels was observed in the treated group that persisted after 16 weeks and was associated with a significant decrease in parathyroid hormone (PTH) levels during the 8 weeks post-treatment. 25(oh)d 15-22 parathyroid hormone Homo sapiens 144-163 26132208-3 2015 The objective of the present study was to determine whether the increase in serum 25(OH)D concentration following weight loss is associated with improved insulin sensitivity, insulin secretion and disposition index (beta-cell function). 25(oh)d 82-89 insulin Homo sapiens 154-161 25904602-1 2015 BACKGROUND: Vitamin D-binding protein (DBP) is the primary carrier of 25-hydroxyvitamin D [25(OH)D] in the circulation. 25(oh)d 91-98 GC vitamin D binding protein Homo sapiens 12-37 25904602-1 2015 BACKGROUND: Vitamin D-binding protein (DBP) is the primary carrier of 25-hydroxyvitamin D [25(OH)D] in the circulation. 25(oh)d 91-98 D-box binding PAR bZIP transcription factor Homo sapiens 39-42 25346256-9 2015 A multiple linear regression analysis revealed that the serum 25(OH)D concentration was inversely related to the LDL-C/HDL-C, TG, ApoB and ApoB/ApoA-1 values, even after adjusting for age, season, smoking status, alcohol consumption, medication use, vitamin D intake, calcium intake, VFA and cardiorespiratory fitness. 25(oh)d 62-69 component of oligomeric golgi complex 2 Homo sapiens 113-118 25858328-2 2015 This study was performed to investigate the optimal 25(OH)D concentration in regard to parathyroid hormone (PTH) concentration in the Korean general population aged 50 years or older. 25(oh)d 52-59 parathyroid hormone Homo sapiens 87-106 25858328-2 2015 This study was performed to investigate the optimal 25(OH)D concentration in regard to parathyroid hormone (PTH) concentration in the Korean general population aged 50 years or older. 25(oh)d 52-59 parathyroid hormone Homo sapiens 108-111 24797104-11 2015 Therefore, the measurement of serum 25(OH)D levels and appropriate vitamin D supplementation should be considered in anemic patients, particularly in females and patients with high CRP level. 25(oh)d 36-43 C-reactive protein Homo sapiens 181-184 25740907-10 2015 CONCLUSION: Subjects with PreDM and low circulating 25(OH)D concentrations are the subgroup of nondiabetic individuals who are the most insulin resistant and have impaired beta-cell function, attributes that put them at enhanced risk of T2DM. 25(oh)d 52-59 insulin Homo sapiens 136-143 25346256-9 2015 A multiple linear regression analysis revealed that the serum 25(OH)D concentration was inversely related to the LDL-C/HDL-C, TG, ApoB and ApoB/ApoA-1 values, even after adjusting for age, season, smoking status, alcohol consumption, medication use, vitamin D intake, calcium intake, VFA and cardiorespiratory fitness. 25(oh)d 62-69 apolipoprotein B Homo sapiens 130-134 25346256-9 2015 A multiple linear regression analysis revealed that the serum 25(OH)D concentration was inversely related to the LDL-C/HDL-C, TG, ApoB and ApoB/ApoA-1 values, even after adjusting for age, season, smoking status, alcohol consumption, medication use, vitamin D intake, calcium intake, VFA and cardiorespiratory fitness. 25(oh)d 62-69 apolipoprotein B Homo sapiens 139-143 25346256-9 2015 A multiple linear regression analysis revealed that the serum 25(OH)D concentration was inversely related to the LDL-C/HDL-C, TG, ApoB and ApoB/ApoA-1 values, even after adjusting for age, season, smoking status, alcohol consumption, medication use, vitamin D intake, calcium intake, VFA and cardiorespiratory fitness. 25(oh)d 62-69 apolipoprotein A1 Homo sapiens 144-150 24899811-10 2014 Regression analysis showed vitamin D deficiency and serum 25(OH)D level to be significantly associated with the presence of RLS (odds ratio [OR] 5.085, P<0.001 and OR 1.047, P=0.006, respectively). 25(oh)d 58-65 RLS1 Homo sapiens 124-127 24692218-2 2014 Our aim was to investigate whether plasma 25-hydroxyvitamin D [25(OH)D] concentrations associate with the development of beta-cell autoimmunity and the transcriptional activity of FOXP3 or vitamin D3 convertase gene (CYP27B1) in CD4+ memory T cells. 25(oh)d 63-70 forkhead box P3 Homo sapiens 180-185 24692218-2 2014 Our aim was to investigate whether plasma 25-hydroxyvitamin D [25(OH)D] concentrations associate with the development of beta-cell autoimmunity and the transcriptional activity of FOXP3 or vitamin D3 convertase gene (CYP27B1) in CD4+ memory T cells. 25(oh)d 63-70 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 217-224 24954334-1 2014 PURPOSE: A low serum 25-hydroxyvitamin D [25(OH)D] level in the blood has been correlated with an increased risk of diabetes mellitus; however, the association between serum 25(OH)D level and insulin resistance has not been established in a Korean rural population. 25(oh)d 42-49 insulin Homo sapiens 192-199 24954334-1 2014 PURPOSE: A low serum 25-hydroxyvitamin D [25(OH)D] level in the blood has been correlated with an increased risk of diabetes mellitus; however, the association between serum 25(OH)D level and insulin resistance has not been established in a Korean rural population. 25(oh)d 174-181 insulin Homo sapiens 192-199 24644045-2 2014 Our objective was to investigate the association between prediagnostic circulating 25-hydroxyvitamin D [25(OH)D] serum levels and the risk of HCC in a prospective, nested case-control study among 520,000 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. 25(oh)d 104-111 HCC Homo sapiens 142-145 25186304-1 2014 The inverse relationship between 25-hydroxyvitamin D [25(OH)D] status and insulin resistance (IR) has been reported, but many interventional studies failed to reduce IR with 25(OH)D supplementation. 25(oh)d 54-61 insulin Homo sapiens 74-81 23659537-11 2014 Serum 25(OH)D levels were statistically lower in adolescents with weight excess, abdominal obesity, hypercholesterolaemia, higher levels of parathyroid hormone, insulin resistance, hyperinsulinaemia and hypertension (P < 0.05). 25(oh)d 6-13 insulin Homo sapiens 161-168 24587115-9 2014 To conclude, our results provide supporting evidence that common polymorphisms in GC and CYP2R1 are associated with serum 25(OH)D concentrations in the Caucasian population and that certain haplotypes may predispose to lower 25(OH)D concentrations in late summer in Denmark. 25(oh)d 122-129 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 89-95 24167365-2 2013 This study aimed to test two hypotheses: (1) serum 25-hydroxyvitamin D [25(OH)D] is inversely associated with type 2 diabetes mellitus (T2DM) and elevated hemoglobin A1c; (2) these associations are mediated by serum C-reactive protein (CRP). 25(oh)d 72-79 C-reactive protein Homo sapiens 216-234 23509804-6 2013 Only insulin or HOMA(IR) maintained a significant independent association with 25(OH)D levels, whereas vitamin D did not maintain a significant independent association with CRP or C3 or C4 concentrations. 25(oh)d 79-86 insulin Homo sapiens 5-12 24394913-6 2014 However, we found that VDR ApaI/AC genotype was significantly associated with 25(OH)D levels (P=0.01). 25(oh)d 78-85 vitamin D receptor Homo sapiens 23-26 24200978-0 2014 Serum 25(OH)D and vitamin D status in relation to VDR, GC and CYP2R1 variants in Chinese. 25(oh)d 6-13 vitamin D receptor Homo sapiens 50-53 24200978-0 2014 Serum 25(OH)D and vitamin D status in relation to VDR, GC and CYP2R1 variants in Chinese. 25(oh)d 6-13 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 62-68 24290086-2 2013 Low levels of serum 25-hydroxy vitamin D [25(OH)D], as a marker of vitamin D deficiency, have been linked to a wide field of health problems, including metabolic diseases such as insulin resistance, type 1 and type 2 DM. 25(oh)d 42-49 insulin Homo sapiens 179-186 24054764-2 2013 A new paradigm is emerging with the locally synthesized 1,25(OH)2D within osteoblasts and osteoclasts as the essential pathway for the effects of 25(OH)D in regulating bone remodeling via direct or indirect activation of the specific receptor VDR. 25(oh)d 146-153 vitamin D receptor Homo sapiens 243-246 23754696-7 2013 25(OH)D levels inversely correlated with CTG expansion size, while IGF1 levels and muscle strength directly correlated with levels of 25(OH)D lower than 20 and 10 ng/ml, respectively. 25(oh)d 134-141 insulin like growth factor 1 Homo sapiens 67-71 23754696-11 2013 DM1 patients show a reduction of circulating 25(OH)D, which correlates with genotype and may influence IGF1 levels and proximal muscle strength. 25(oh)d 45-52 insulin like growth factor 1 Homo sapiens 103-107 23221508-1 2013 BACKGROUND: 25-Hydroxyvitamin D [25(OH)D] is a marker of nutritional status; however, chronic kidney disease (CKD) results in alterations in vitamin D metabolism, including the loss of vitamin D-binding proteins and alterations in CYP27B1 and CYP24 enzymes that metabolize 25(OH)D. This study was designed to determine the predictors of responsiveness to correction of vitamin D deficiency with oral vitamin D2 (ergocalciferol) in adults. 25(oh)d 33-40 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 231-238 23221508-1 2013 BACKGROUND: 25-Hydroxyvitamin D [25(OH)D] is a marker of nutritional status; however, chronic kidney disease (CKD) results in alterations in vitamin D metabolism, including the loss of vitamin D-binding proteins and alterations in CYP27B1 and CYP24 enzymes that metabolize 25(OH)D. This study was designed to determine the predictors of responsiveness to correction of vitamin D deficiency with oral vitamin D2 (ergocalciferol) in adults. 25(oh)d 33-40 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 243-248 22990991-1 2013 This study was designed to examine differences in serum 25(OH)D levels between small-for-gestational-age (SGA) and appropriate-for-gestational-age (AGA) prepubertal children in correlation with birth weight and indices of insulin resistance and beta-cell function. 25(oh)d 56-63 insulin Homo sapiens 222-229 23281695-3 2013 AIM: To evaluate serum 25(OH)D levels in vitiligo patients with and without systemic autoimmune diseases. 25(oh)d 23-30 VAMAS6 Homo sapiens 41-49 23281695-10 2013 CONCLUSION: Deficient serum 25(OH)D levels are present in vitiligo patients with and without systemic autoimmune diseases. 25(oh)d 28-35 VAMAS6 Homo sapiens 58-66 24167365-2 2013 This study aimed to test two hypotheses: (1) serum 25-hydroxyvitamin D [25(OH)D] is inversely associated with type 2 diabetes mellitus (T2DM) and elevated hemoglobin A1c; (2) these associations are mediated by serum C-reactive protein (CRP). 25(oh)d 72-79 C-reactive protein Homo sapiens 236-239 22437564-2 2012 After 24 wk, serum 25-hydroxyvitamin D [25(OH)D] decreased by >80% in the NWD1 group compared with controls, but with no alteration in serum calcium or bone mineral density. 25(oh)d 40-47 NACHT and WD repeat domain containing 1 Mus musculus 77-81 23372745-9 2013 Serum 25(OH)D concentration correlated negatively with both IL-6 (P = 0.02) and hsCRP serum concentration (P = 0.03) at baseline. 25(oh)d 6-13 interleukin 6 Homo sapiens 60-64 23095332-8 2012 CONCLUSIONS: We conclude that plasma hCAP18 levels correlate with serum 25(OH)D levels in subjects with concentrations of 25(OH)D <= 32 ng/ml as opposed to those with concentrations > 32 ng/ml and that vitamin D status may regulate systemic levels of hCAP18/LL-37. 25(oh)d 72-79 cathelicidin antimicrobial peptide Homo sapiens 37-43 22624410-2 2012 The aim of this study was to establish the prevalence of inadequate serum 25-hydroxyvitamin D [25(OH)D] concentrations in postmenopausal Serbian women with seasonal variations of 25(OH)D, in relation to parathyroid hormone (PTH) and bone mineral density (BMD). 25(oh)d 95-102 parathyroid hormone Homo sapiens 203-222 22114830-3 2011 The current study was aimed at evaluating the relationship between 25(OH)D levels and concomitant parathyroid hormone levels. 25(oh)d 67-74 parathyroid hormone Homo sapiens 98-117 21924736-3 2012 Serum 25(OH)D was correlated with urinary vitamin D binding protein/creatinine ratio (DBP/C) and other indicators of proteinuria. 25(oh)d 6-13 D-box binding PAR bZIP transcription factor Homo sapiens 86-89 21924736-4 2012 RESULTS: Serum 25(OH)D levels in subjects with SLE were inversely associated with the natural log of urinary DBP/C (r=-0.63, P<.001) and urine protein to creatinine ratio (r=-0.60, P<.001), with an adjusted mean 10.9-ng/mL (95% CI, 5.1-16.8) decrease in 25(OH)D for those with proteinuria. 25(oh)d 15-22 D-box binding PAR bZIP transcription factor Homo sapiens 109-112 22153538-11 2012 CONCLUSIONS: Serum 25(OH)D levels<50 nmol/L are frequent in PHPT, are more common than in controls, and are associated with more severe bone disease based on higher serum PTH and bone turnover biomarkers. 25(oh)d 19-26 parathyroid hormone Homo sapiens 174-177 22493740-7 2012 We also found a significantly positive association between plasma 25(OH)D levels and SCC risk after adjusting for the same covariates (OR, highest vs. lowest quartile = 3.77, 95% CI = 1.70-8.36, P for trend= 0.0002). 25(oh)d 66-73 serpin family B member 3 Homo sapiens 85-88 22145146-2 2011 Both obesity and 25-hydroxy vitamin D [25(OH)D] deficiency have been associated with hypertension and augmented renin-angiotensin system (RAS) activity. 25(oh)d 39-46 renin Homo sapiens 112-117 21613813-8 2011 25-hydroxyvitamin D [25(OH)D] levels significantly increased from 28.0+-11.0 ng/ml at baseline to 51.3+-17.3 and 52.4+-21.5 at V2 and V3, respectively (p<0.001). 25(oh)d 21-28 nibrin Homo sapiens 124-129 22616336-8 2011 Serum 25(OH)D levels were negatively correlated with PTH levels (r -0.027, p <0.00001) and BMI (r -0.128, p 0.05). 25(oh)d 6-13 parathyroid hormone Homo sapiens 53-56 21613558-2 2011 OBJECTIVE: We investigated the relation of serum 25(OH)D concentrations to fasting insulin, glucose, dyslipidemia, adiposity, and prevalent metabolic syndrome. 25(oh)d 49-56 insulin Homo sapiens 83-90 21287159-6 2011 Serum 25(OH)D levels were negatively related to age and serum levels of Cr and PTH; they were positively related to bone mineral density (BMD). 25(oh)d 6-13 parathyroid hormone Homo sapiens 79-82 21537045-1 2011 PURPOSE: Data suggest that circulating 25-hydroxyvitamin D [25(OH)D] interacts with the vitamin D receptor (VDR) to decrease proliferation and increase apoptosis for some malignancies, although evidence for prostate cancer is less clear. 25(oh)d 60-67 vitamin D receptor Homo sapiens 88-106 21537045-1 2011 PURPOSE: Data suggest that circulating 25-hydroxyvitamin D [25(OH)D] interacts with the vitamin D receptor (VDR) to decrease proliferation and increase apoptosis for some malignancies, although evidence for prostate cancer is less clear. 25(oh)d 60-67 vitamin D receptor Homo sapiens 108-111 21389086-6 2011 RESULTS: 25-Hydroxyvitamin D (25(OH)D) levels showed significant negative correlation with IR and positive correlation with insulin sensitivity (P<0.05 for all) in PCOS women. 25(oh)d 30-37 insulin Homo sapiens 124-131 20150902-3 2010 Thus, we aimed to investigate the relationship between 25(OH)D concentration and insulin-sensitivity, using the glucose clamp technique. 25(oh)d 55-62 insulin Homo sapiens 81-88 21556227-2 2011 This study aimed to determine the association between 25(OH)D and MeS among Jordanian adults. 25(oh)d 54-61 MKS transition zone complex subunit 1 Homo sapiens 66-69 21556227-14 2011 Prospective studies are necessary to better determine the roles of 25(OH)D levels in the etiology of MeS. 25(oh)d 67-74 MKS transition zone complex subunit 1 Homo sapiens 101-104 21177785-12 2011 CONCLUSION: D3 is approximately 87% more potent in raising and maintaining serum 25(OH)D concentrations and produces 2- to 3-fold greater storage of vitamin D than does equimolar D2. 25(oh)d 81-88 iodothyronine deiodinase 3 Homo sapiens 12-14 20658560-1 2011 We have recently observed an increasing number of patients presenting very high serum levels of 25-hydroxyvitamin D [25(OH)D] (> 150 ng/mL), which, in all cases, had been measured with the IDS EIA kit adapted on different "open" automated platforms. 25(oh)d 117-124 iduronate 2-sulfatase Homo sapiens 192-195 20861177-1 2010 BACKGROUND: Circulating 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) concentrations have been shown to be associated with insulin sensitivity; however, adiposity may confound this relation. 25(oh)d 45-52 insulin Homo sapiens 137-144 20155247-3 2010 INTRODUCTION: The upper level of 25-hydroxyvitamin D [25(OH)D] which constitutes a long-term bone health risk by causing elevated PTH levels is uncertain. 25(oh)d 54-61 parathyroid hormone Homo sapiens 130-133 20215450-1 2010 OBJECTIVE: To examine cross-sectional associations of serum vitamin D [25-hydroxyvitamin D, 25(OH)D] concentration with insulin resistance (IR) and beta-cell dysfunction in 712 subjects at risk for type 2 diabetes. 25(oh)d 92-99 insulin Homo sapiens 120-127 19364661-5 2009 The physiological buffer for vitamin D safety is the capacity of plasma vitamin D-binding protein to bind the total of circulating 25(OH)D, vitamin D, and 1,25-dihydroxyvitamin D [1,25(OH)2D]. 25(oh)d 131-138 GC vitamin D binding protein Homo sapiens 72-97 19436930-11 2010 CONCLUSIONS: Serum 25(OH)D levels above 60 nmol/l in Northern Irish adolescent girls prevent an increase in serum PTH levels and maintaining 25(OH)D >60 nmol/l in both girls and boys may lead to improved bone health outcomes. 25(oh)d 19-26 parathyroid hormone Homo sapiens 114-117 19675671-11 2009 CONCLUSIONS/SIGNIFICANCE: These results show an association of high 25(OH)D levels with an improved Treg function, and with skewing of the Th1/Th2 balance towards Th2. 25(oh)d 68-75 negative elongation factor complex member C/D Homo sapiens 139-142 16937272-1 2006 This study was designed to determine the threshold value for 25-hydroxyvitamin D [25(OH)D] concentration in relation to elevated serum parathyroid hormone (PTH) concentrations in elderly Japanese women. 25(oh)d 82-89 parathyroid hormone Homo sapiens 135-154 19111635-7 2009 A univariate analysis indicated a negative association for 25(OH)D with 1-84 PTH and bone ALP. 25(oh)d 59-66 ATHS Homo sapiens 90-93 19492580-10 2009 A highly significant negative correlation was found between serum 25(OH)D and PTH in mothers (r = -0.480, p = 0.01) and their infants (r = -0.431, p = 0.01). 25(oh)d 66-73 parathyroid hormone Homo sapiens 78-81 17372031-1 2007 Hydroxylation of 25(OH)D to 1,25-dihydroxyvitamin D and signaling through the vitamin D receptor occur in various tissues not traditionally involved in calcium homeostasis. 25(oh)d 17-24 vitamin D receptor Homo sapiens 78-96 16807549-12 2006 In conclusion, 25(OH)D(3) suppresses PTH synthesis by parathyroid cells, possibly by direct activation of the VDR. 25(oh)d 15-22 parathyroid hormone Bos taurus 37-40 16807549-12 2006 In conclusion, 25(OH)D(3) suppresses PTH synthesis by parathyroid cells, possibly by direct activation of the VDR. 25(oh)d 15-22 vitamin D receptor Homo sapiens 110-113 18088161-15 2007 There was inconsistent evidence of an association of circulating 25(OH)D with bone mineral content in infants, and fair evidence that serum 25(OH)D is inversely associated with serum PTH. 25(oh)d 140-147 parathyroid hormone Homo sapiens 183-186 15175848-6 2005 The primary goal was to determine serum 25(OH)D concentrations in relation to circulating PTH levels in a population of adolescent girls. 25(oh)d 40-47 parathyroid hormone Homo sapiens 90-93 15776219-9 2005 PTH and serum alkaline phosphatase (SAP) was significantly high in patients with 25(OH)D deficiency (p < 0.05) compared with those with normal 25(OH)D levels. 25(oh)d 81-88 parathyroid hormone Homo sapiens 0-3 15776219-9 2005 PTH and serum alkaline phosphatase (SAP) was significantly high in patients with 25(OH)D deficiency (p < 0.05) compared with those with normal 25(OH)D levels. 25(oh)d 81-88 SH2 domain containing 1A Homo sapiens 36-39 15776219-10 2005 There was a negative correlation between 25(OH)D and PTH (r = -0.2; p < 0.007) and SAP (r = -0.2; p < 0.001). 25(oh)d 41-48 parathyroid hormone Homo sapiens 53-56 33806559-11 2021 CONCLUSION: Our novel data on the relationship between VDR gene variants and BMD, 25(OH)D level, and OP risk highlights the importance of genetic markers for personalized medicine strategy. 25(oh)d 82-89 vitamin D receptor Homo sapiens 55-58 15452403-6 2004 Regression analysis indicated that there was a negative correlation between 25(OH)D and intact parathyroid hormone (PTH). 25(oh)d 76-83 parathyroid hormone Homo sapiens 95-114 15070925-7 2004 The reciprocal relation between serum PTH and serum 25(OH)D could not be explained by the serum concentration of 1,25-dihydroxyvitamin D, which did not change with age. 25(oh)d 52-59 parathyroid hormone Homo sapiens 38-41 9916136-4 1999 DBP markedly prolonged the serum half-life of 25(OH)D and less dramatically prolonged the half-life of vitamin D by slowing its hepatic uptake and increasing the efficiency of its conversion to 25(OH)D in the liver. 25(oh)d 46-53 D site albumin promoter binding protein Mus musculus 0-3 9916136-4 1999 DBP markedly prolonged the serum half-life of 25(OH)D and less dramatically prolonged the half-life of vitamin D by slowing its hepatic uptake and increasing the efficiency of its conversion to 25(OH)D in the liver. 25(oh)d 194-201 D site albumin promoter binding protein Mus musculus 0-3 8835303-10 1995 A statistically significant correlation between PTH and 25(OH)D concentrations (r = 0.493; p = 0.0001) was obtained. 25(oh)d 56-63 parathyroid hormone Homo sapiens 48-51 33940646-10 2021 A positive correlation was found between hepcidin and ferritin (R2 = 0.247, p = 0.02) and a negative correlation was found between 25(OH)D and CRP (R2 = 0.1, p = 0.04). 25(oh)d 131-138 C-reactive protein Homo sapiens 143-146 33940646-15 2021 Negative correlation was found between 25(OH)D and CRP.. 25(oh)d 39-46 C-reactive protein Homo sapiens 51-54 15113720-2 2004 OBJECTIVE: We investigated the relation of 25-hydroxyvitamin D [25(OH)D] concentrations to insulin sensitivity and beta cell function. 25(oh)d 64-71 insulin Homo sapiens 91-98 15113720-10 2004 CONCLUSIONS: The data show a positive correlation of 25(OH)D concentration with insulin sensitivity and a negative effect of hypovitaminosis D on beta cell function. 25(oh)d 53-60 insulin Homo sapiens 80-87 33944665-1 2021 OBJECTIVE: To verify the association between 25(OH)D level and polymorphisms in the vitamin D receptor gene (VDR) with the disturbance in the dental development and eruption. 25(oh)d 45-52 vitamin D receptor Homo sapiens 84-102 33944665-1 2021 OBJECTIVE: To verify the association between 25(OH)D level and polymorphisms in the vitamin D receptor gene (VDR) with the disturbance in the dental development and eruption. 25(oh)d 45-52 vitamin D receptor Homo sapiens 109-112 33807159-6 2021 An inverse association was observed between 25(OH)D and salivary CRP in a model adjusted for age, smoking status, frequency of tooth brushing and flossing, and hormone therapy use (-7.56% difference in salivary CRP concentrations per 10 nmol/L increase in 25(OH)D, 95% CI: -12.78 to -2.03). 25(oh)d 44-51 C-reactive protein Homo sapiens 65-68 33807159-6 2021 An inverse association was observed between 25(OH)D and salivary CRP in a model adjusted for age, smoking status, frequency of tooth brushing and flossing, and hormone therapy use (-7.56% difference in salivary CRP concentrations per 10 nmol/L increase in 25(OH)D, 95% CI: -12.78 to -2.03). 25(oh)d 44-51 C-reactive protein Homo sapiens 211-214 33591401-11 2021 According to the adjusted regression analysis, the deficient status of 25(OH)D in men was associated with worse bone health for the lumbar spine sites (beta = - 0.1; p = 0.006), femoral neck (beta = - 0.08; p = 0.006), and hip (beta = - 0.08; p = 0.009). 25(oh)d 71-78 hedgehog interacting protein Homo sapiens 223-226 33031174-7 2021 Elevated plasma PTH (>=79 pg/ml) was found in 24% of preeclamptic women who had 25(OH)D plasma levels of 21.4 +- 8.3 ng/ml. 25(oh)d 80-87 parathyroid hormone Homo sapiens 16-19 34544076-7 2022 RESULTS: Serum 25(OH)D negatively correlated with serum IL-17, the platelet/lymphocyte ratio, and TSH receptor antibody. 25(oh)d 15-22 interleukin 17A Homo sapiens 56-61 33504033-6 2021 Our analyses suggest that in the 3rd trimester of pregnancy, a 25(OH)D level of 18.9 ng/mL (47.3 nmol/L) could serve as an inflection point for the maximal suppression of PTH. 25(oh)d 63-70 parathyroid hormone Homo sapiens 171-174 33504033-7 2021 Statistically significant determinants of PTH concentrations in multiple regression were 25(OH)D concentrations, season, multiparity and education of the partner (all p < 0.05) in early pregnancy. 25(oh)d 89-96 parathyroid hormone Homo sapiens 42-45 33504033-8 2021 In late pregnancy, 25(OH)D concentrations and country of origin were statistically significant determinants of PTH concentrations (all p < 0.05). 25(oh)d 19-26 parathyroid hormone Homo sapiens 111-114 33504033-9 2021 These factors and their effect on PTH appear to be vastly determined by 25(OH)D; however, they might also affect PTH through other mechanisms besides 25(OH)D. 25(oh)d 72-79 parathyroid hormone Homo sapiens 34-37 34678476-3 2022 Serum 25(OH)D levels have been negatively correlated with serum IL-6 levels in patients with chronic inflammation. 25(oh)d 6-13 interleukin 6 Homo sapiens 64-68 34678476-5 2022 We aimed to compare the serum 25(OH)D and IL-6 levels between OSAS patients and controls, examine a possible correlation between 25(OH)D and IL-6 levels and the changes of their concentrations after twelve months of CPAP therapy in OSAS patients. 25(oh)d 129-136 interleukin 6 Homo sapiens 141-145 34587322-7 2022 25(OH)D concentration was significantly inversely correlated with birth weight and PTH, and positively with urinary calcium/creatinine ratio and calciuria. 25(oh)d 0-7 parathyroid hormone Homo sapiens 83-86 34544076-7 2022 RESULTS: Serum 25(OH)D negatively correlated with serum IL-17, the platelet/lymphocyte ratio, and TSH receptor antibody. 25(oh)d 15-22 thyroid stimulating hormone receptor Homo sapiens 98-110 34977236-8 2021 The genotypes C/T and T/T of PTHR1 rs1138518 were associated with 25-hydroxy-vitamin D (25(OH)D) regulation. 25(oh)d 88-95 parathyroid hormone 1 receptor Homo sapiens 29-34 34977236-10 2021 Our study concludes that the PTHR1 rs1138518 genotype could be a potential risk factor for osteoporosis and 25(OH)D regulation in Arab women with PMO. 25(oh)d 108-115 parathyroid hormone 1 receptor Homo sapiens 29-34 34948669-1 2021 Background: The aim of this study was to assess the relationship between serum 25-hydroxyvitamin D (25(OH)D) and serum intact parathyroid hormone (PTH) in Chinese childbearing women, and to estimate the optimum threshold of 25(OH)D that maximally inhibits the PTH, which is considered to be the optimal status for vitamin D sufficiency. 25(oh)d 100-107 parathyroid hormone Homo sapiens 126-145 34960039-8 2021 During puberty, the increase in triacylglycerols, insulin, and HOMA-IR and the decrease in QUICKI were significantly associated with the reduction in 25(OH)D (B = -0.274, p = 0.032; B = -0.219, p = 0.019; B = -0.250, p = 0.013; B = 1.574, p = 0.013, respectively) after adjustment by BMI-z, sex, and pubertal stage. 25(oh)d 150-157 insulin Homo sapiens 50-57 34944511-2 2021 Cytochrome P450 2R1 (CYP2R1) encoded by the CYP2R1 gene is the major hydroxylase that activates vitamin D by catalyzing the formation of 25-hydroxyvitamin D (25(OH)D). 25(oh)d 158-165 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 0-19 34944511-2 2021 Cytochrome P450 2R1 (CYP2R1) encoded by the CYP2R1 gene is the major hydroxylase that activates vitamin D by catalyzing the formation of 25-hydroxyvitamin D (25(OH)D). 25(oh)d 158-165 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 21-27 34944511-2 2021 Cytochrome P450 2R1 (CYP2R1) encoded by the CYP2R1 gene is the major hydroxylase that activates vitamin D by catalyzing the formation of 25-hydroxyvitamin D (25(OH)D). 25(oh)d 158-165 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 44-50 34944511-7 2021 CONCLUSIONS: Variant NC_000011.10: g.14878291G>A may have a perturbing effect on heme binding in the active site of CYP2R1 and on the function of 25-hydroxylase and probably affects the concentration of 25(OH)D in vivo. 25(oh)d 203-210 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 116-122 34948669-1 2021 Background: The aim of this study was to assess the relationship between serum 25-hydroxyvitamin D (25(OH)D) and serum intact parathyroid hormone (PTH) in Chinese childbearing women, and to estimate the optimum threshold of 25(OH)D that maximally inhibits the PTH, which is considered to be the optimal status for vitamin D sufficiency. 25(oh)d 224-231 parathyroid hormone Homo sapiens 260-263 34948669-4 2021 Simple linear and partial correlation analysis, locally weighted regression smooth scatterplot (LOESS), nonlinear least squares estimation (NLS), and segmented regression (SR) were utilized to estimate the relationship of 25(OH)D and PTH, and to determine the threshold of 25(OH)D. 25(oh)d 222-229 parathyroid hormone Homo sapiens 234-237 34948669-6 2021 A significant inverse relationship between 25(OH)D and PTH concentration was observed below 15.25 (14.22-16.28) ng/mL, and PTH decreased slowly with the increase of 25(OH)D above 16.75 (15.43-18.06) ng/mL after adjusting by age, latitude, city type, season, corrected calcium, and phosphorus. 25(oh)d 43-50 parathyroid hormone Homo sapiens 55-58 34948669-6 2021 A significant inverse relationship between 25(OH)D and PTH concentration was observed below 15.25 (14.22-16.28) ng/mL, and PTH decreased slowly with the increase of 25(OH)D above 16.75 (15.43-18.06) ng/mL after adjusting by age, latitude, city type, season, corrected calcium, and phosphorus. 25(oh)d 165-172 parathyroid hormone Homo sapiens 123-126 34948669-7 2021 A very short plateau of PTH was found at 15.25 ng/mL and 16.75 ng/mL in terms of 25(OH)D according to LOESS, NLS, and SR. 25(oh)d 81-88 parathyroid hormone Homo sapiens 24-27 34948669-8 2021 Conclusions: The serum 25(OH)D was negatively correlated with the serum PTH. 25(oh)d 23-30 parathyroid hormone Homo sapiens 72-75 34948669-1 2021 Background: The aim of this study was to assess the relationship between serum 25-hydroxyvitamin D (25(OH)D) and serum intact parathyroid hormone (PTH) in Chinese childbearing women, and to estimate the optimum threshold of 25(OH)D that maximally inhibits the PTH, which is considered to be the optimal status for vitamin D sufficiency. 25(oh)d 100-107 parathyroid hormone Homo sapiens 147-150 34948669-1 2021 Background: The aim of this study was to assess the relationship between serum 25-hydroxyvitamin D (25(OH)D) and serum intact parathyroid hormone (PTH) in Chinese childbearing women, and to estimate the optimum threshold of 25(OH)D that maximally inhibits the PTH, which is considered to be the optimal status for vitamin D sufficiency. 25(oh)d 100-107 parathyroid hormone Homo sapiens 260-263 34948669-1 2021 Background: The aim of this study was to assess the relationship between serum 25-hydroxyvitamin D (25(OH)D) and serum intact parathyroid hormone (PTH) in Chinese childbearing women, and to estimate the optimum threshold of 25(OH)D that maximally inhibits the PTH, which is considered to be the optimal status for vitamin D sufficiency. 25(oh)d 224-231 parathyroid hormone Homo sapiens 126-145 34948669-1 2021 Background: The aim of this study was to assess the relationship between serum 25-hydroxyvitamin D (25(OH)D) and serum intact parathyroid hormone (PTH) in Chinese childbearing women, and to estimate the optimum threshold of 25(OH)D that maximally inhibits the PTH, which is considered to be the optimal status for vitamin D sufficiency. 25(oh)d 224-231 parathyroid hormone Homo sapiens 147-150 34855907-8 2021 RESULTS: The DBP-related SNPs showed no difference in 25(OH)D status at baseline, but carriers of the rs7041 risk allele showed lower 25(OH)D-levels compared to non-carriers after 48 weeks of supplementation (median 224.2 vs. 332.0 nmol/L, p = 0.013). 25(oh)d 134-141 D-box binding PAR bZIP transcription factor Homo sapiens 13-16 34855907-6 2021 Participants were categorised as either "carriers" or "non-carriers" of the risk allele for 4 SNPs: two related to D binding protein (DBP) and associated with lower 25(OH)D levels (rs4588 and rs7041), and two related to vitamin D metabolism enzymes CYP27B1 and CYP24A1 and associated with a higher risk of MS (rs12368653; rs2248359, respectively). 25(oh)d 165-172 D-box binding PAR bZIP transcription factor Homo sapiens 134-137 34849546-13 2022 CONCLUSIONS: Of characteristics most commonly associated with vitamin D metabolism, only baseline 25(OH)D <20 ng/mL modified the PTH response to vitamin D supplementation, providing support from a clinical trial to use this threshold to define insufficiency. 25(oh)d 98-105 parathyroid hormone Homo sapiens 129-132 34890855-10 2021 After adjustments (including %body fat and BMI), an inverse association was observed between 25(OH)D and visceral adipose tissue (B = -6.46, 95% confidence interval, CI: -12.87, -0.04), leptin (B = -0.09, 95% confidence interval, CI: -0.14, -0.03), insulin (B = -0.21, 95%CI: -0.34, -0.07), HOMA-IR (B = -0.06, 95%CI: -0.10, -0.02), triglycerides (B = -2.44, 95%CI: -3.66, -1.22), and TNF-alpha (B = -0.12, 95%CI: -0.24, -0.005) only in MU individuals. 25(oh)d 93-100 tumor necrosis factor Homo sapiens 385-394 34797893-0 2021 Genetic variations of CYP2R1 (rs10741657) in Bangladeshi adults with low serum 25(OH)D level-A pilot study. 25(oh)d 79-86 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 22-28 34950833-1 2021 Our predominant understanding of the actions of vitamin D involve binding of its ligand, 1,25(OH)D, to the vitamin D receptor (VDR), which for its genomic actions binds to discrete regions of its target genes called vitamin D response elements. 25(oh)d 91-98 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 107-125 34950833-1 2021 Our predominant understanding of the actions of vitamin D involve binding of its ligand, 1,25(OH)D, to the vitamin D receptor (VDR), which for its genomic actions binds to discrete regions of its target genes called vitamin D response elements. 25(oh)d 91-98 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 127-130 34849546-8 2022 Within the vitamin D3 group, lower baseline 25(OH)D was associated with a larger decline in PTH in a non-linear fashion. 25(oh)d 44-51 parathyroid hormone Homo sapiens 92-95 34849546-9 2022 With baseline 25(OH)D >=30 ng/mL as the reference, 25(OH)D <20 ng/mL was associated with a larger decline in PTH with vitamin D3 supplementation (-10 (95% CI: -15, -6) pg/mL) whereas 25(OH)D 20-30 ng/mL was not (-2 (95% CI: -6, 1) pg/mL). 25(oh)d 51-58 parathyroid hormone Homo sapiens 109-112 34849546-10 2022 A segmented threshold model identified a baseline 25(OH)D concentration of 21 (95% CI: 13, 31) ng/mL as an inflection point for difference in change in PTH. 25(oh)d 50-57 parathyroid hormone Homo sapiens 152-155 34797893-3 2021 However, the genetic variations of CYP2R1 (rs10741657) and their association with low serum 25(OH)D level in Bangladeshi adults are yet to be explored. 25(oh)d 92-99 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 35-41 34797893-4 2021 OBJECTIVE: This study was conducted to determine the frequency of variants of rs10741657 of CYP2R1 gene and its association with low serum 25(OH)D level among Bangladeshi adults. 25(oh)d 139-146 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 92-98 34797893-10 2021 The association between GG and GA genotypes of CYP2R1 (rs10741657) with low serum 25(OH)D level among the study population was found and it was statistically significant. 25(oh)d 82-89 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 47-53 34797893-12 2021 CONCLUSIONS: The presence of "GG" and "GA" genotypes of rs1041657 in CYP2R1 gene is associated with low serum 25(OH)D level among Bangladeshi adults in this pilot study. 25(oh)d 110-117 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 69-75 34869440-8 2021 In the Zol-treated women, the percent change of VEGF levels between baseline and day-30 (-18% at day-30 vs. baseline, p = 0.01) was significantly associated with serum 25(OH)D values (r = 0.29, p = 0.028). 25(oh)d 168-175 vascular endothelial growth factor A Homo sapiens 48-52 34869440-9 2021 At a stepwise multiple regression analysis, after correcting for age, BMI, time since menopause, femoral neck BMD, osteocalcin, C-terminal telopeptide of type 1 collagen, and baseline VEGF levels, 25(OH)D levels were independently associated with VEGF change (beta = 1.7, SE = 0.71, p = 0.03). 25(oh)d 197-204 vascular endothelial growth factor A Homo sapiens 184-188 34869440-9 2021 At a stepwise multiple regression analysis, after correcting for age, BMI, time since menopause, femoral neck BMD, osteocalcin, C-terminal telopeptide of type 1 collagen, and baseline VEGF levels, 25(OH)D levels were independently associated with VEGF change (beta = 1.7, SE = 0.71, p = 0.03). 25(oh)d 197-204 vascular endothelial growth factor A Homo sapiens 247-251 34139758-11 2021 Age-, sex- and seasonal variation-adjusted odds ratios for hospital admission were 2.3-2.4 times higher among participants with serum 25(OH)D <50 nmol/L, compared to those with normal serum 25(OH)D levels, without any excess mortality risk. 25(oh)d 134-141 renin binding protein Homo sapiens 0-3 34857984-9 2021 In conclusion, modest improvements in vitamin D supplementation on short-term glycose homeostasis, insulin sensitivity, and disease development in diabetes and prediabetes with 25(OH)D<30 ng/ml were demonstrated, but more research needs to be conducted in the future to support the clinical application. 25(oh)d 177-184 insulin Homo sapiens 99-106 34702787-10 2022 The association between TPA and serum 25(OH)D levels was more robust in high sedentary time. 25(oh)d 38-45 plasminogen activator, tissue type Homo sapiens 24-27 34836237-2 2021 However, 25(OH)D is mostly bound to the vitamin D binding protein (VDBP) or albumin in blood, and it has been suggested that the remaining bioavailable or free 25(OH)D may be more relevant for vitamin D associated health outcomes. 25(oh)d 9-16 GC vitamin D binding protein Homo sapiens 40-65 34836237-2 2021 However, 25(OH)D is mostly bound to the vitamin D binding protein (VDBP) or albumin in blood, and it has been suggested that the remaining bioavailable or free 25(OH)D may be more relevant for vitamin D associated health outcomes. 25(oh)d 9-16 GC vitamin D binding protein Homo sapiens 67-71 34836237-9 2021 Strong variations by VDBP genotypes were seen for bioavailable and free 25(OH)D, and, in opposite direction for non-bioavailable 25(OH)D. 25(oh)d 72-79 GC vitamin D binding protein Homo sapiens 21-25 34139758-11 2021 Age-, sex- and seasonal variation-adjusted odds ratios for hospital admission were 2.3-2.4 times higher among participants with serum 25(OH)D <50 nmol/L, compared to those with normal serum 25(OH)D levels, without any excess mortality risk. 25(oh)d 190-197 renin binding protein Homo sapiens 0-3 34675985-9 2021 The 25(OH)D level of the APR + subjects was 16.75 +- 9.20 ng/mL, significantly lower than that of the APR- patients (23.68 +- 10.67 ng/mL). 25(oh)d 4-11 phorbol-12-myristate-13-acetate-induced protein 1 Homo sapiens 25-28 34549226-7 2021 In addition, serum 25(OH)D was associated with both mRNA gene expression and methylation of key genes, such as interleukin (IL)6, IL10, vitamin D receptor (VDR) or cytochrome P450 subfamily 27 type B1 (CYP27B1) (p < 0.05). 25(oh)d 19-26 interleukin 10 Homo sapiens 130-134 34549226-7 2021 In addition, serum 25(OH)D was associated with both mRNA gene expression and methylation of key genes, such as interleukin (IL)6, IL10, vitamin D receptor (VDR) or cytochrome P450 subfamily 27 type B1 (CYP27B1) (p < 0.05). 25(oh)d 19-26 vitamin D receptor Homo sapiens 136-154 34549226-7 2021 In addition, serum 25(OH)D was associated with both mRNA gene expression and methylation of key genes, such as interleukin (IL)6, IL10, vitamin D receptor (VDR) or cytochrome P450 subfamily 27 type B1 (CYP27B1) (p < 0.05). 25(oh)d 19-26 vitamin D receptor Homo sapiens 156-159 34549226-7 2021 In addition, serum 25(OH)D was associated with both mRNA gene expression and methylation of key genes, such as interleukin (IL)6, IL10, vitamin D receptor (VDR) or cytochrome P450 subfamily 27 type B1 (CYP27B1) (p < 0.05). 25(oh)d 19-26 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 164-200 34549226-7 2021 In addition, serum 25(OH)D was associated with both mRNA gene expression and methylation of key genes, such as interleukin (IL)6, IL10, vitamin D receptor (VDR) or cytochrome P450 subfamily 27 type B1 (CYP27B1) (p < 0.05). 25(oh)d 19-26 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 202-209 34549226-8 2021 Interestingly, while high IL6 expression was related to poor survival in CRC (p < 0.05), IL6 methylation was associated with an increased risk of CRC, in which 25(OH)D partially mediated this association (p < 0.05). 25(oh)d 160-167 interleukin 6 Homo sapiens 89-92 34549226-9 2021 Our study suggests a potential association between epigenetic regulation of inflammatory mediators in VAT - such as IL6 - in the CRC context, in which 25(OH)D may mediate this risk. 25(oh)d 151-158 interleukin 6 Homo sapiens 116-119 34666727-1 2021 BACKGROUND: To examine the association between circulating 25(OH)D concentrations and incidence of total hip replacement for osteoarthritis in a prospective cohort study. 25(oh)d 59-66 hedgehog interacting protein Homo sapiens 105-108 34666727-4 2021 Cox proportional hazard regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of total hip replacement for osteoarthritis in relation to 25(OH)D concentrations, adjusted for confounders. 25(oh)d 168-175 hedgehog interacting protein Homo sapiens 118-121 34666727-6 2021 Compared with men in the lowest (1st) quartile of 25(OH)D concentration, the HR for total hip replacement was 2.32 (95% CI 1.05, 5.13) for those in the 2nd quartile, 2.77 (95% CI 1.28, 6.00) for those in the 3rd quartile, and 1.73 (95% CI 0.75, 4.02) for those in the highest quartile of 25(OH)D concentrations (p for trend 0.02). 25(oh)d 50-57 hedgehog interacting protein Homo sapiens 90-93 34666727-8 2021 CONCLUSIONS: Higher circulating 25(OH)D concentrations were associated with an increased risk of total hip replacement for osteoarthritis in men but not in women. 25(oh)d 32-39 hedgehog interacting protein Homo sapiens 103-106 34617343-8 2021 All the included studies found that supplementation of vitamin D (D2 and D3 ), regardless of dosage, increased 25(OH)D levels compared to a placebo. 25(oh)d 111-118 immunoglobulin heavy diversity 2-15 Homo sapiens 66-75 34624060-11 2021 The correlation between 25(OH)D and PTH was weak but significant (r = -0.197; p<0.001). 25(oh)d 24-31 parathyroid hormone Homo sapiens 36-39 34624060-16 2021 Serum 25(OH)D, calcium, weeks of pregnancy, and educational level were determinants of serum PTH. 25(oh)d 6-13 parathyroid hormone Homo sapiens 93-96 34642402-2 2021 Therefore, we aimed to investigate the relationship between deficiency/insufficiency levels of 25(OH)D and luteinizing hormone (LH), follicle-stimulating hormone (FSH), total (TT), free (FT), and bioavailable testosterone (BT), and sex hormone binding globulin (SHBG) in young, healthy men. 25(oh)d 95-102 sex hormone binding globulin Homo sapiens 232-260 34615940-8 2021 Upregulation of expression of CYP2R1 in mice with bile duct ligation significantly increased the level of 25(OH)D, decreased the expression of TGF-beta1, Col-1alpha1 and TIMP-1, and increased the expression of MMP-2. 25(oh)d 106-113 cytochrome P450, family 2, subfamily r, polypeptide 1 Mus musculus 30-36 34620331-8 2021 25(OH)D deficient obese subjects exhibited higher serum levels of MDA as well as erythrocyte SOD activity (p < 0.05) and lower serum levels of TAC (p < 0.0001), PON1 (p < 0.05), and AREase (p < 0.0001) compared to obese subjects with 25(OH)D sufficiency and controls even when adjusted for BMI. 25(oh)d 0-7 superoxide dismutase 1 Homo sapiens 93-96 34620331-8 2021 25(OH)D deficient obese subjects exhibited higher serum levels of MDA as well as erythrocyte SOD activity (p < 0.05) and lower serum levels of TAC (p < 0.0001), PON1 (p < 0.05), and AREase (p < 0.0001) compared to obese subjects with 25(OH)D sufficiency and controls even when adjusted for BMI. 25(oh)d 0-7 paraoxonase 1 Homo sapiens 161-165 34433211-8 2021 25(OH)D showed a significant negative correlation with MCP-1, ESR, blood viscosity, atherogenic index of plasma and FRS among total study subjects. 25(oh)d 0-7 C-C motif chemokine ligand 2 Homo sapiens 55-60 34089603-5 2021 Elevated serum 25(OH)D concentrations were significantly associated with lower levels of insulin, HOMA-IR, triglyceride, and C-reactive protein, and higher levels of high-density lipoprotein at baseline (all Ptrend<0.05). 25(oh)d 15-22 insulin Homo sapiens 89-96 34433211-9 2021 Further, logistics regression analysis showed an association of 25(OH)D with MCP-1, hematocrit, fibrinogen, and blood viscosity. 25(oh)d 64-71 C-C motif chemokine ligand 2 Homo sapiens 77-82 34433211-9 2021 Further, logistics regression analysis showed an association of 25(OH)D with MCP-1, hematocrit, fibrinogen, and blood viscosity. 25(oh)d 64-71 fibrinogen beta chain Homo sapiens 96-106 34274459-1 2021 BACKGROUND: Concentrations of serum 25-hydroxyvitamin D (25(OH)D) below 20 ng/mL and above 50 ng/mL have been associated with chronic adverse events including cardiovascular disease. 25(oh)d 57-64 thrombopoietin Mus musculus 78-80 34274459-11 2021 Adjusted cardiovascular disease hazard ratios (HRs) (95% confidence interval) for 25(OH)D values <12, 12-19, and >50 ng/mL, compared to the reference range 20-50 ng/mL, were 1.28 (1.12-1.46), 1.19 (1.09-1.31), and 1.10 (0.95-1.26), respectively. 25(oh)d 82-89 thrombopoietin Mus musculus 120-122 34274459-12 2021 CONCLUSION: Values of 25(OH)D <20 ng/mL were associated with development of a new diagnosis of cardiovascular disease. 25(oh)d 22-29 thrombopoietin Mus musculus 37-39 34684492-4 2021 Low 25-hydroxyvitamin D (25(OH)D) levels appear to be associated with most of the insulin resistance disorders described to date. 25(oh)d 25-32 insulin Homo sapiens 82-89 34684492-7 2021 An important question is the identification of 25(OH)D levels capable of generating an effect on insulin resistance, glucose metabolism and to decrease the risk of developing insulin resistance related disorders. 25(oh)d 47-54 insulin Homo sapiens 97-104 34684492-7 2021 An important question is the identification of 25(OH)D levels capable of generating an effect on insulin resistance, glucose metabolism and to decrease the risk of developing insulin resistance related disorders. 25(oh)d 47-54 insulin Homo sapiens 175-182 34684492-8 2021 The benefits of 25(OH)D supplementation/repletion on bone health are well known, and although there is a biological plausibility linking the status of vitamin D and insulin resistance supported by basic and clinical research findings, well-designed randomized clinical trials as well as basic research are necessary to know the molecular pathways involved in this association. 25(oh)d 16-23 insulin Homo sapiens 165-172 34089603-5 2021 Elevated serum 25(OH)D concentrations were significantly associated with lower levels of insulin, HOMA-IR, triglyceride, and C-reactive protein, and higher levels of high-density lipoprotein at baseline (all Ptrend<0.05). 25(oh)d 15-22 C-reactive protein Homo sapiens 125-143 34579742-10 2021 Serum 25(OH)D exhibited positive correlation with hemoglobin (r = 0.4509, p = 0.0002), RBC (r = 0.3712, p = 0.0030), TIBC (r = 0.4700, p = 0.0001), SOD (r = 0.4992, p < 0.0001) and GSH-Px (r = 0.4312, p = 0.0005), and negative correlation with hs-CRP (r = - 0.4040, p = 0.0011), TNF-alpha (r = - 0.4721, p = 0.0001), IL-6 (r = - 0.5378, p < 0.0001) and MDA (r = - 0.3056, p = 0.0157). 25(oh)d 6-13 superoxide dismutase 1 Homo sapiens 148-151 34579742-10 2021 Serum 25(OH)D exhibited positive correlation with hemoglobin (r = 0.4509, p = 0.0002), RBC (r = 0.3712, p = 0.0030), TIBC (r = 0.4700, p = 0.0001), SOD (r = 0.4992, p < 0.0001) and GSH-Px (r = 0.4312, p = 0.0005), and negative correlation with hs-CRP (r = - 0.4040, p = 0.0011), TNF-alpha (r = - 0.4721, p = 0.0001), IL-6 (r = - 0.5378, p < 0.0001) and MDA (r = - 0.3056, p = 0.0157). 25(oh)d 6-13 C-reactive protein Homo sapiens 247-250 34579742-10 2021 Serum 25(OH)D exhibited positive correlation with hemoglobin (r = 0.4509, p = 0.0002), RBC (r = 0.3712, p = 0.0030), TIBC (r = 0.4700, p = 0.0001), SOD (r = 0.4992, p < 0.0001) and GSH-Px (r = 0.4312, p = 0.0005), and negative correlation with hs-CRP (r = - 0.4040, p = 0.0011), TNF-alpha (r = - 0.4721, p = 0.0001), IL-6 (r = - 0.5378, p < 0.0001) and MDA (r = - 0.3056, p = 0.0157). 25(oh)d 6-13 tumor necrosis factor Homo sapiens 279-288 34579742-10 2021 Serum 25(OH)D exhibited positive correlation with hemoglobin (r = 0.4509, p = 0.0002), RBC (r = 0.3712, p = 0.0030), TIBC (r = 0.4700, p = 0.0001), SOD (r = 0.4992, p < 0.0001) and GSH-Px (r = 0.4312, p = 0.0005), and negative correlation with hs-CRP (r = - 0.4040, p = 0.0011), TNF-alpha (r = - 0.4721, p = 0.0001), IL-6 (r = - 0.5378, p < 0.0001) and MDA (r = - 0.3056, p = 0.0157). 25(oh)d 6-13 interleukin 6 Homo sapiens 317-321 34591347-7 2021 In addition, the mean serum 25(OH)D concentration was significantly lower in the patient group than that in control group (p < 0.05), and serum CRP was significantly increased (p < 0.05). 25(oh)d 28-35 C-reactive protein Homo sapiens 144-147 34580590-11 2021 Higher serum calcium and 25(OH)D levels and lower BMI were significant predictors of a blunted PTH response, which may indicate that these subjects are adapting to lower 25(OH)D levels and maintaining normal calcium levels without the need to increase PTH secretion. 25(oh)d 25-32 parathyroid hormone Homo sapiens 95-98 34684321-7 2021 Additionally, 25(OH)D negatively correlated with IGF-1, while the correlation with P1NP was not significant. 25(oh)d 14-21 insulin like growth factor 1 Homo sapiens 49-54 34684322-2 2021 The bioavailability of 25(OH)D is regulated by the albumin, vitamin D binding protein (VDBP), and variants of the GC gene. 25(oh)d 23-30 albumin Homo sapiens 51-58 34684322-2 2021 The bioavailability of 25(OH)D is regulated by the albumin, vitamin D binding protein (VDBP), and variants of the GC gene. 25(oh)d 23-30 GC vitamin D binding protein Homo sapiens 60-85 34684322-2 2021 The bioavailability of 25(OH)D is regulated by the albumin, vitamin D binding protein (VDBP), and variants of the GC gene. 25(oh)d 23-30 GC vitamin D binding protein Homo sapiens 87-91 34580590-9 2021 Multiple logistic regression analysis showed that lower BMI (OR = 0.925; 95% CI: 0.949-0.987) and higher 25(OH)D (OR = 1.068; 95% CI: 1.014-1.124) and serum calcium (OR = 8.600; 95% CI: 1.614-45.809) levels were significantly associated with a blunted PTH response (R 2 = 0.178). 25(oh)d 105-112 parathyroid hormone Homo sapiens 252-255 34551710-12 2021 CONCLUSION: We found evidence that VDR genotype may modify the association between 25(OH)D and some PMSx. 25(oh)d 83-90 vitamin D receptor Homo sapiens 35-38 34580590-11 2021 Higher serum calcium and 25(OH)D levels and lower BMI were significant predictors of a blunted PTH response, which may indicate that these subjects are adapting to lower 25(OH)D levels and maintaining normal calcium levels without the need to increase PTH secretion. 25(oh)d 170-177 parathyroid hormone Homo sapiens 95-98 34232092-7 2021 In addition, Nrf2 and CBR1 expression levels were lower in the maternal 25(OH)D deficient placenta. 25(oh)d 72-79 NFE2 like bZIP transcription factor 2 Homo sapiens 13-17 34133827-1 2021 OBJECTIVE: To investigate whether there is a difference in serum 25-hydroxyvitamin D (25(OH)D) concentration between patients with benign paroxysmal positional vertigo (BPPV), patients with other vestibular diseases, and patients with other neurological non-vestibular diseases presenting in a tertiary neurological academic outpatient clinic. 25(oh)d 86-93 benign paroxysmal positional vertigo Homo sapiens 169-173 34579103-1 2021 (1) Background: Observational studies have established that vitamin D-binding protein (DBP) and 25-hydroxyvitamin D3 (25(OH)D) concentrations are the major factors affecting the bioavailability of 25(OH)D. 25(oh)d 197-204 GC vitamin D binding protein Homo sapiens 60-85 34579103-1 2021 (1) Background: Observational studies have established that vitamin D-binding protein (DBP) and 25-hydroxyvitamin D3 (25(OH)D) concentrations are the major factors affecting the bioavailability of 25(OH)D. 25(oh)d 197-204 D-box binding PAR bZIP transcription factor Homo sapiens 87-90 34232092-7 2021 In addition, Nrf2 and CBR1 expression levels were lower in the maternal 25(OH)D deficient placenta. 25(oh)d 72-79 carbonyl reductase 1 Homo sapiens 22-26 34406392-4 2021 OBJECTIVES: To investigate the sex-dependency of the association of insulin resistance and 25-hydroxyvitamin D (25(OH)D) in a large Caucasian population. 25(oh)d 112-119 insulin Homo sapiens 68-75 34449504-9 2021 As bioavailable 25(OH)D levels are affected mainly by VDBP levels, VDBP may play a role in the lower femur neck BMD values observed in the agricultural group. 25(oh)d 16-23 GC vitamin D binding protein Homo sapiens 54-58 34378863-7 2022 No significance difference was found in mean changes of serum IL-6 level in the both groups, except subgroup patients with vitamin D deficiency or serum 25(OH)D < 20 ng/mL, high dose treatment suppressed serum IL-6 level (-2.67 pg/mL (IQR -6.56 to -0.17), P = 0.039). 25(oh)d 153-160 thrombopoietin Mus musculus 169-171 34380489-9 2021 RESULTS: Overall, 25(OH)D was inversely associated with fasting glucose (r=-0.165, P = 0.037), insulin (r=-0.184, P = 0.02), C-peptide (r=-0.19, P = 0.015) and HOMA2- IR C-peptide (r=-0.23, P = 0.004). 25(oh)d 18-25 insulin Homo sapiens 95-102 34380489-9 2021 RESULTS: Overall, 25(OH)D was inversely associated with fasting glucose (r=-0.165, P = 0.037), insulin (r=-0.184, P = 0.02), C-peptide (r=-0.19, P = 0.015) and HOMA2- IR C-peptide (r=-0.23, P = 0.004). 25(oh)d 18-25 insulin Homo sapiens 125-134 34380489-9 2021 RESULTS: Overall, 25(OH)D was inversely associated with fasting glucose (r=-0.165, P = 0.037), insulin (r=-0.184, P = 0.02), C-peptide (r=-0.19, P = 0.015) and HOMA2- IR C-peptide (r=-0.23, P = 0.004). 25(oh)d 18-25 insulin Homo sapiens 170-179 34380489-11 2021 In the white ethnic group but not in black or Asian population groups, 25(OH)D level was also associated with only serum fasting C-peptide and HOMA2-IR C-peptide and BMI (P < 0.05). 25(oh)d 71-78 insulin Homo sapiens 129-138 34380489-11 2021 In the white ethnic group but not in black or Asian population groups, 25(OH)D level was also associated with only serum fasting C-peptide and HOMA2-IR C-peptide and BMI (P < 0.05). 25(oh)d 71-78 insulin Homo sapiens 152-161 34456863-12 2021 After controlling for age, sex, disease duration, serum 25(OH)D, phosphorus, and calcium concentration, the positive correlation between OCN and PTH was still statistically significant (r = 0.323, p = 0.000). 25(oh)d 56-63 bone gamma-carboxyglutamate protein Homo sapiens 137-140 34315477-7 2021 However, using 25(OH)D synthesis SNP (DHCR7; rs12785878) as an individual genetic instrument, a per allele reduction of 25(OH)D concentration (-4.2nmol/L +- SE 0.3nmol/L) was predicted to increase T2D risk by 5%, p = 0.004; Z score 2.84. 25(oh)d 120-127 7-dehydrocholesterol reductase Homo sapiens 38-43 34590566-13 2021 After adjusting for age, gender, atrial fibrillation, nutritional risk, hs-CRP and other confounding factors, serum 25(OH)D was an independent protective factor for the infarct volume of AIS in anterior circulation (odds ratio (OR) = 0.962, P = 0.040), For every 10 mug/L decrease of 25(OH)D, the risk of one grade increase in infarction volume was increased by 47.7% respectively (goodness of fit: chi2 = 5.357, P = 0.719). 25(oh)d 116-123 C-reactive protein Homo sapiens 75-78 34590566-13 2021 After adjusting for age, gender, atrial fibrillation, nutritional risk, hs-CRP and other confounding factors, serum 25(OH)D was an independent protective factor for the infarct volume of AIS in anterior circulation (odds ratio (OR) = 0.962, P = 0.040), For every 10 mug/L decrease of 25(OH)D, the risk of one grade increase in infarction volume was increased by 47.7% respectively (goodness of fit: chi2 = 5.357, P = 0.719). 25(oh)d 284-291 C-reactive protein Homo sapiens 75-78 34362787-1 2021 BACKGROUND AND OBJECTIVES: Low serum 25-hydroxyvitamin D (25(OH)D) concentration has been associated with higher levels of proteinuria and lower levels of eGFR in observational studies. 25(oh)d 58-65 epidermal growth factor receptor Homo sapiens 155-159 34117551-2 2021 This study aimed to investigate whether the threshold level of 25(OH)D for the diagnosis of vitamin D deficiency (VDD) in obese adolescents was lower than that in controls and to compare 25(OH)DT, free (25(OH)DF) and bioavailable (25(OH)DB) vitamin D with VDBP levels in obese individuals and their controls. 25(oh)d 63-70 GC vitamin D binding protein Homo sapiens 256-260 34389701-8 2021 Changes of 25(OH)D were a significant predictor of changes of adiponectin. 25(oh)d 11-18 adiponectin, C1Q and collagen domain containing Homo sapiens 62-73 34315477-7 2021 However, using 25(OH)D synthesis SNP (DHCR7; rs12785878) as an individual genetic instrument, a per allele reduction of 25(OH)D concentration (-4.2nmol/L +- SE 0.3nmol/L) was predicted to increase T2D risk by 5%, p = 0.004; Z score 2.84. 25(oh)d 15-22 7-dehydrocholesterol reductase Homo sapiens 38-43 34281061-4 2021 Therefore, the aim of our study was to investigate the relationship between 25(OH)D concentration and selected cytokines-IL-6, TNF-alpha, and IL-1beta, which are hemogram parameters for professional football players. 25(oh)d 76-83 tumor necrosis factor Homo sapiens 127-136 34281061-4 2021 Therefore, the aim of our study was to investigate the relationship between 25(OH)D concentration and selected cytokines-IL-6, TNF-alpha, and IL-1beta, which are hemogram parameters for professional football players. 25(oh)d 76-83 interleukin 1 alpha Homo sapiens 142-150 34281061-11 2021 We found a significant negative correlation between 25(OH)D levels and TNF-alpha and LYMPH (%). 25(oh)d 52-59 tumor necrosis factor Homo sapiens 71-80 34248925-6 2021 The association of NKA with 25-(OH)-vitamin D (25(OH)D) and other factors was investigated by multiple logistic regression analysis. 25(oh)d 47-54 tachykinin precursor 1 Homo sapiens 19-22 34249156-10 2021 The achieved mean serum 25(OH)D concentration in adults supplemented with 10 mug NF per day remained below 200 nmol/L. 25(oh)d 24-31 neurofascin Homo sapiens 81-83 34258354-4 2021 Design: and Methods: 25(OH)D was analyzed in 184 serum samples in an IDS-iSYS Multi-Discipline Automated System Analyzer (Vitro) and in an Alinity i automated Analyzer (Abbott). 25(oh)d 21-28 iduronate 2-sulfatase Homo sapiens 69-72 34166428-17 2021 Serum 25(OH)D <20 ng/ml was associated with CD4 count <=15% at ART initiation OR 6.55(1.30-32.9), p value-0.023 and use of NNRTIs; OR 10.9(1.22-96.2), p value-0.03. 25(oh)d 6-13 CD4 molecule Homo sapiens 44-47 34125662-12 2022 (25(OH)D) inversely correlated with the Homeostatic Model Assessment for Insulin Resistance and remained significant after adjustment for BMI. 25(oh)d 1-8 insulin Homo sapiens 73-80 34080787-4 2021 METHODS: Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), for 25(OH)D, DBP, and the molar ratio of 25(OH)D:DBP, an estimate of unbound (free) 25(OH)D levels. 25(oh)d 150-157 D-box binding PAR bZIP transcription factor Homo sapiens 158-161 34925568-2 2021 Patients and Method: This study was designed as a retrospective, cross-sectional two-center study for examining the elderly patients with very high 25(OH)D levels (>88ng/mL) between January 2014 and December 2019. 25(oh)d 148-155 thrombopoietin Mus musculus 170-172 34078483-5 2022 Plasma 25(OH)D was analyzed by LC-MS/MS and free 25(OH)D was calculated utilizing the levels and binding affinities of DBP and albumin for 25(OH)D. 25(oh)d 49-56 D-box binding PAR bZIP transcription factor Homo sapiens 119-122 34078483-5 2022 Plasma 25(OH)D was analyzed by LC-MS/MS and free 25(OH)D was calculated utilizing the levels and binding affinities of DBP and albumin for 25(OH)D. 25(oh)d 139-146 D-box binding PAR bZIP transcription factor Homo sapiens 119-122 34079693-9 2021 RESULTS: Linear regression found no correlation between population vitamin D concentrations and the total cases-recovered/M, but negative correlations predicting a reduction of 47%-64%-80% in serious-critical illnesses/M and of 61%-82%-102.4% in deaths/M further enhanced when adapting for life expectancy by 133-177-221% if 25(OH)D concentrations reach 100-125-150 nmol/L, sustained on August 15, 2020, indicating a truthful association. 25(oh)d 325-332 membrane glycoprotein Severe acute respiratory syndrome coronavirus 2 219-220 34079693-9 2021 RESULTS: Linear regression found no correlation between population vitamin D concentrations and the total cases-recovered/M, but negative correlations predicting a reduction of 47%-64%-80% in serious-critical illnesses/M and of 61%-82%-102.4% in deaths/M further enhanced when adapting for life expectancy by 133-177-221% if 25(OH)D concentrations reach 100-125-150 nmol/L, sustained on August 15, 2020, indicating a truthful association. 25(oh)d 325-332 membrane glycoprotein Severe acute respiratory syndrome coronavirus 2 253-254 34193674-11 2021 In the multinomial logistic regression model, albumin level was the only factor significantly correlated with higher 25(OH)D concentrations in the sufficient and insufficient groups compared with the deficient group. 25(oh)d 117-124 albumin Homo sapiens 46-53 34177089-8 2021 The lower serum 25(OH)D was observed in the following gene/genotypes: KNG1 rs11924390 T/T; ANKH rs2454873 G/G; NPFFR2 rs4129733 T/G; SH2B1 rs4788102 G/A; RAP1A rs494453 T/T and CRHBP rs7728378 T/C. 25(oh)d 16-23 kininogen 1 Homo sapiens 70-74 34177089-8 2021 The lower serum 25(OH)D was observed in the following gene/genotypes: KNG1 rs11924390 T/T; ANKH rs2454873 G/G; NPFFR2 rs4129733 T/G; SH2B1 rs4788102 G/A; RAP1A rs494453 T/T and CRHBP rs7728378 T/C. 25(oh)d 16-23 ANKH inorganic pyrophosphate transport regulator Homo sapiens 91-95 34177089-8 2021 The lower serum 25(OH)D was observed in the following gene/genotypes: KNG1 rs11924390 T/T; ANKH rs2454873 G/G; NPFFR2 rs4129733 T/G; SH2B1 rs4788102 G/A; RAP1A rs494453 T/T and CRHBP rs7728378 T/C. 25(oh)d 16-23 neuropeptide FF receptor 2 Homo sapiens 111-117 34177089-8 2021 The lower serum 25(OH)D was observed in the following gene/genotypes: KNG1 rs11924390 T/T; ANKH rs2454873 G/G; NPFFR2 rs4129733 T/G; SH2B1 rs4788102 G/A; RAP1A rs494453 T/T and CRHBP rs7728378 T/C. 25(oh)d 16-23 SH2B adaptor protein 1 Homo sapiens 133-138 34177089-8 2021 The lower serum 25(OH)D was observed in the following gene/genotypes: KNG1 rs11924390 T/T; ANKH rs2454873 G/G; NPFFR2 rs4129733 T/G; SH2B1 rs4788102 G/A; RAP1A rs494453 T/T and CRHBP rs7728378 T/C. 25(oh)d 16-23 RAP1A, member of RAS oncogene family Homo sapiens 154-159 34177089-8 2021 The lower serum 25(OH)D was observed in the following gene/genotypes: KNG1 rs11924390 T/T; ANKH rs2454873 G/G; NPFFR2 rs4129733 T/G; SH2B1 rs4788102 G/A; RAP1A rs494453 T/T and CRHBP rs7728378 T/C. 25(oh)d 16-23 corticotropin releasing hormone binding protein Homo sapiens 177-182 34289005-2 2021 25-hydroxy vitamin D (25(OH)D) may contribute, via the production of the antimicrobial peptide cathelicidin (LL-37), to epithelial host defense against S. aureus. 25(oh)d 22-29 cathelicidin antimicrobial peptide Homo sapiens 109-114 34759139-2 2021 The serum 25-hydroxyvitamin D (25(OH)D) level was 13.4 +- 0.8 ng / mL and it markedly increased to 29.6 +- 0.9 ng / mL after daily 1000-IU vitamin D-fortified milk intake for 6 months. 25(oh)d 31-38 thrombopoietin Mus musculus 67-69 34719611-6 2021 Multiple regression analysis revealed that the association between 25(OH)D concentrations and TG levels was statistically significant (p<0.01) after adjusting for age, sex, body mass index, estimated glomerular flow rate (eGFR), insulin use, duration of diabetes mellitus, glycosylated hemoglobin (HbA1c), alcohol consumption, current smoking, and sampling timing. 25(oh)d 67-74 insulin Homo sapiens 229-236 34538041-11 2021 When comparing the results of biochemical studies, it was revealed that children with VD deficiency (25(OH)D <20 ng/ml) had statistically significantly higher medians of PTH, TC, TG, ALT, AST, glucose, insulin, HOMA-IR and lower P and Ca level compared with children with normal micronutrient blood content (p<0.05). 25(oh)d 101-108 parathyroid hormone Homo sapiens 170-173 34538041-11 2021 When comparing the results of biochemical studies, it was revealed that children with VD deficiency (25(OH)D <20 ng/ml) had statistically significantly higher medians of PTH, TC, TG, ALT, AST, glucose, insulin, HOMA-IR and lower P and Ca level compared with children with normal micronutrient blood content (p<0.05). 25(oh)d 101-108 solute carrier family 17 member 5 Homo sapiens 188-191 34538041-11 2021 When comparing the results of biochemical studies, it was revealed that children with VD deficiency (25(OH)D <20 ng/ml) had statistically significantly higher medians of PTH, TC, TG, ALT, AST, glucose, insulin, HOMA-IR and lower P and Ca level compared with children with normal micronutrient blood content (p<0.05). 25(oh)d 101-108 insulin Homo sapiens 202-209 34538041-12 2021 The medians of ALT, AST, TC, ss-lipoproteins, TG, glucose, insulin and HOMA-IR levels in obese children with VD deficiency were statistically significantly higher than in children with normal body weight and VD deficiency and in healthy children with an optimal concentration of 25(OH)D. 25(oh)d 279-286 solute carrier family 17 member 5 Homo sapiens 20-23 34538041-12 2021 The medians of ALT, AST, TC, ss-lipoproteins, TG, glucose, insulin and HOMA-IR levels in obese children with VD deficiency were statistically significantly higher than in children with normal body weight and VD deficiency and in healthy children with an optimal concentration of 25(OH)D. 25(oh)d 279-286 insulin Homo sapiens 59-66 35364123-9 2022 RESULTS: Diabetes led to a decrease in serum 25(OH)D that was accompanied by down-regulation of vitamin D receptor (VDR) expression and up-regulation of hydroxylases CYP24A1 and CYP27B1 synthesis in the kidneys. 25(oh)d 45-52 vitamin D receptor Homo sapiens 96-114 35364123-9 2022 RESULTS: Diabetes led to a decrease in serum 25(OH)D that was accompanied by down-regulation of vitamin D receptor (VDR) expression and up-regulation of hydroxylases CYP24A1 and CYP27B1 synthesis in the kidneys. 25(oh)d 45-52 vitamin D receptor Homo sapiens 116-119 35364123-9 2022 RESULTS: Diabetes led to a decrease in serum 25(OH)D that was accompanied by down-regulation of vitamin D receptor (VDR) expression and up-regulation of hydroxylases CYP24A1 and CYP27B1 synthesis in the kidneys. 25(oh)d 45-52 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 166-173 35364123-9 2022 RESULTS: Diabetes led to a decrease in serum 25(OH)D that was accompanied by down-regulation of vitamin D receptor (VDR) expression and up-regulation of hydroxylases CYP24A1 and CYP27B1 synthesis in the kidneys. 25(oh)d 45-52 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 178-185 35351538-2 2022 The degree of PTH inhibition in humans by circulating 25(OH)D and 1,25(OH)2D may be different. 25(oh)d 54-61 parathyroid hormone Homo sapiens 14-17 35633918-1 2022 Background: Previous studies examined the association between chronic pain (CP) and serum 25-hydroxyvitamin D (25(OH)D) concentrations; however, the findings obtained were inconsistent. 25(oh)d 111-118 ceruloplasmin Homo sapiens 62-74 35633918-1 2022 Background: Previous studies examined the association between chronic pain (CP) and serum 25-hydroxyvitamin D (25(OH)D) concentrations; however, the findings obtained were inconsistent. 25(oh)d 111-118 ceruloplasmin Homo sapiens 76-78 35633918-2 2022 Single nucleotide polymorphisms (SNP) associated with the transcriptional activity of the vitamin D receptor (VDR) gene may influence the association of 25(OH)D levels with CP. 25(oh)d 153-160 vitamin D receptor Homo sapiens 90-108 35633918-2 2022 Single nucleotide polymorphisms (SNP) associated with the transcriptional activity of the vitamin D receptor (VDR) gene may influence the association of 25(OH)D levels with CP. 25(oh)d 153-160 vitamin D receptor Homo sapiens 110-113 35633918-2 2022 Single nucleotide polymorphisms (SNP) associated with the transcriptional activity of the vitamin D receptor (VDR) gene may influence the association of 25(OH)D levels with CP. 25(oh)d 153-160 ceruloplasmin Homo sapiens 173-175 35633918-8 2022 We observed a tendency for lower 25(OH)D levels in participants with CP than in those without CP in the hetero/minor group of rs11568820, which is a polymorphism within the CDX2-binding site in the 1e promoter region of the VDR gene. 25(oh)d 33-40 ceruloplasmin Homo sapiens 69-71 35633918-8 2022 We observed a tendency for lower 25(OH)D levels in participants with CP than in those without CP in the hetero/minor group of rs11568820, which is a polymorphism within the CDX2-binding site in the 1e promoter region of the VDR gene. 25(oh)d 33-40 ceruloplasmin Homo sapiens 94-96 35633918-8 2022 We observed a tendency for lower 25(OH)D levels in participants with CP than in those without CP in the hetero/minor group of rs11568820, which is a polymorphism within the CDX2-binding site in the 1e promoter region of the VDR gene. 25(oh)d 33-40 caudal type homeobox 2 Homo sapiens 173-177 35633918-8 2022 We observed a tendency for lower 25(OH)D levels in participants with CP than in those without CP in the hetero/minor group of rs11568820, which is a polymorphism within the CDX2-binding site in the 1e promoter region of the VDR gene. 25(oh)d 33-40 vitamin D receptor Homo sapiens 224-227 35633918-9 2022 Furthermore, a logistic regression analysis revealed that lower serum 25(OH)D concentrations were significantly associated with CP in the hetero/minor group, but not in the major group. 25(oh)d 70-77 ceruloplasmin Homo sapiens 128-130 35633918-10 2022 Conclusion: These results suggest that sufficient serum 25(OH)D concentration reduces the risk of CP in individuals with the minor allele of the CDX2 polymorphism. 25(oh)d 56-63 ceruloplasmin Homo sapiens 98-100 35633918-10 2022 Conclusion: These results suggest that sufficient serum 25(OH)D concentration reduces the risk of CP in individuals with the minor allele of the CDX2 polymorphism. 25(oh)d 56-63 caudal type homeobox 2 Homo sapiens 145-149 35513795-9 2022 Baseline 25-(OH) D levels and CD4+ T cell counts were higher in the Normal-25(OH)D group than in the Low-25(OH)D and Low-25(OH)D-Calcitriol groups (25(OH)D: 79.3 +- 3.4 vs. 37.8 +- 13.4 vs. 11.9 nmol/L, P < 0.05; 671 +- 287 vs. 200 +- 110 vs. 194 +- 119 cell/microL, P < 0.05). 25(oh)d 75-82 CD4 molecule Homo sapiens 30-33 35579027-5 2022 RESULTS: In non-linear MR analysis, genetically predicted serum 25(OH)D had an L-shaped association with serum CRP, where CRP levels decreased sharply with increasing 25(OH)D concentration for participants within the deficiency range (<25 nmol/L) and levelled off at ~50 nmol/L of 25(OH)D (Pnon-linear = 1.49E-4). 25(oh)d 64-71 C-reactive protein Homo sapiens 111-114 35579027-5 2022 RESULTS: In non-linear MR analysis, genetically predicted serum 25(OH)D had an L-shaped association with serum CRP, where CRP levels decreased sharply with increasing 25(OH)D concentration for participants within the deficiency range (<25 nmol/L) and levelled off at ~50 nmol/L of 25(OH)D (Pnon-linear = 1.49E-4). 25(oh)d 64-71 C-reactive protein Homo sapiens 122-125 35579027-5 2022 RESULTS: In non-linear MR analysis, genetically predicted serum 25(OH)D had an L-shaped association with serum CRP, where CRP levels decreased sharply with increasing 25(OH)D concentration for participants within the deficiency range (<25 nmol/L) and levelled off at ~50 nmol/L of 25(OH)D (Pnon-linear = 1.49E-4). 25(oh)d 167-174 C-reactive protein Homo sapiens 111-114 35579027-5 2022 RESULTS: In non-linear MR analysis, genetically predicted serum 25(OH)D had an L-shaped association with serum CRP, where CRP levels decreased sharply with increasing 25(OH)D concentration for participants within the deficiency range (<25 nmol/L) and levelled off at ~50 nmol/L of 25(OH)D (Pnon-linear = 1.49E-4). 25(oh)d 167-174 C-reactive protein Homo sapiens 122-125 35579027-5 2022 RESULTS: In non-linear MR analysis, genetically predicted serum 25(OH)D had an L-shaped association with serum CRP, where CRP levels decreased sharply with increasing 25(OH)D concentration for participants within the deficiency range (<25 nmol/L) and levelled off at ~50 nmol/L of 25(OH)D (Pnon-linear = 1.49E-4). 25(oh)d 281-288 C-reactive protein Homo sapiens 111-114 35579027-6 2022 Analyses using several pleiotropy-robust methods provided consistent results in stratified MR analyses, confirming the inverse association between 25(OH)D and CRP in the deficiency range (P = 1.10E-05) but not with higher concentrations. 25(oh)d 147-154 C-reactive protein Homo sapiens 159-162 35579027-8 2022 CONCLUSION: The observed association between 25(OH)D and CRP is likely to be caused by vitamin D deficiency. 25(oh)d 45-52 C-reactive protein Homo sapiens 57-60 35545756-12 2022 There was a possible positive association between serum 25(OH)D and pre-albumin, and a possible negative association between serum 25(OH)D, creatinine, and thrombin time. 25(oh)d 131-138 coagulation factor II, thrombin Homo sapiens 156-164 35631152-6 2022 Poisson models stratified by sex and controlled by covariates demonstrated that deficient serum 25(OH)D was a risk factor for the incidence of IADL disability in men (IRR: 1.43; 95% CI 1.02, 2.00), but not in women (IRR: 1.23; 95% CI 0.94, 1.62). 25(oh)d 96-103 insulin receptor related receptor Homo sapiens 167-170 35631152-6 2022 Poisson models stratified by sex and controlled by covariates demonstrated that deficient serum 25(OH)D was a risk factor for the incidence of IADL disability in men (IRR: 1.43; 95% CI 1.02, 2.00), but not in women (IRR: 1.23; 95% CI 0.94, 1.62). 25(oh)d 96-103 insulin receptor related receptor Homo sapiens 216-219 35629892-11 2022 CONCLUSIONS: The presence of low serum 25(OH)D concentrations after LDLT suggested that post-transplant low serum 25(OH)D concentrations may develop with the homogenous phenomenon of VDR rs2228530 and CYP2R1 rs10741657 genetic modifications in recipients regardless of graft pathology. 25(oh)d 114-121 vitamin D receptor Homo sapiens 183-186 35600603-5 2022 Patients with lower 25(OH)D levels had higher serum creatinine, urinary albumin creatinine ratio (UACR), total cholesterol, and parathyroid hormone levels as well as lower estimated glomerular filtration rate (eGFR), hemoglobin, albumin, and calcium levels and were more prone to diabetic retinopathy (DR). 25(oh)d 20-27 albumin Homo sapiens 72-79 35600603-5 2022 Patients with lower 25(OH)D levels had higher serum creatinine, urinary albumin creatinine ratio (UACR), total cholesterol, and parathyroid hormone levels as well as lower estimated glomerular filtration rate (eGFR), hemoglobin, albumin, and calcium levels and were more prone to diabetic retinopathy (DR). 25(oh)d 20-27 parathyroid hormone Homo sapiens 128-147 35600603-5 2022 Patients with lower 25(OH)D levels had higher serum creatinine, urinary albumin creatinine ratio (UACR), total cholesterol, and parathyroid hormone levels as well as lower estimated glomerular filtration rate (eGFR), hemoglobin, albumin, and calcium levels and were more prone to diabetic retinopathy (DR). 25(oh)d 20-27 albumin Homo sapiens 229-236 35511609-9 2022 In adjusted analyses, a 10 nmol/L increase of s-25(OH)D in early pregnancy associated with a 0.3/0.2 mmHg lower SBP/DBP at 5 years (p <0.05). 25(oh)d 48-55 D-box binding PAR bZIP transcription factor Homo sapiens 116-119 35511609-10 2022 Optimal s-25(OH)D (>75 nmol/L) in early pregnancy was associated with lower 5-year SBP and DBP, beta (95%CI) -1.45 (-2.6,-0.3), and -0.97 (-1.9,-0.1), compared with reference s-25(OH)D 50-74.9 nmol/L. 25(oh)d 10-17 D-box binding PAR bZIP transcription factor Homo sapiens 91-94 35511609-11 2022 Two-stage analysis combining early pregnancy, late pregnancy, and cord s-25(OH)D data showed an inverse association with 5-year SBP and DBP for boys (p <0.025) with significant sex-difference for DBP (pinteraction=0.004). 25(oh)d 73-80 D-box binding PAR bZIP transcription factor Homo sapiens 136-139 35511609-11 2022 Two-stage analysis combining early pregnancy, late pregnancy, and cord s-25(OH)D data showed an inverse association with 5-year SBP and DBP for boys (p <0.025) with significant sex-difference for DBP (pinteraction=0.004). 25(oh)d 73-80 D-box binding PAR bZIP transcription factor Homo sapiens 196-199 35102371-1 2022 BACKGROUND: Vitamin D deficiency has been associated with worse coronavirus disease 2019 (COVID-19) outcomes but circulating 25-hydroxyvitamin D (25(OH)D) is largely bound to vitamin D binding protein (DBP) or albumin both of which tend to fall in illness making 25(OH)D status hard to interpret. 25(oh)d 146-153 D-box binding PAR bZIP transcription factor Homo sapiens 202-205 35102371-1 2022 BACKGROUND: Vitamin D deficiency has been associated with worse coronavirus disease 2019 (COVID-19) outcomes but circulating 25-hydroxyvitamin D (25(OH)D) is largely bound to vitamin D binding protein (DBP) or albumin both of which tend to fall in illness making 25(OH)D status hard to interpret. 25(oh)d 263-270 D-box binding PAR bZIP transcription factor Homo sapiens 202-205 35079976-5 2022 RESULTS: In our patients who underwent elective hip replacement, significant correlations existed between the percent change in the conversion rate of 25(OH)D to 1,25(OH)2D, plasma intact to C-terminal FGF23 ratio, and serum iron. 25(oh)d 151-158 hedgehog interacting protein Homo sapiens 48-51 35571939-3 2022 Cox regression was used to analyze the relationship between Serum 25(OH)D, cadmium, CRP, and all-cause, cause-specific mortality. 25(oh)d 66-73 C-reactive protein Homo sapiens 84-87 35571939-4 2022 We used restricted cubic splines to explore the dose-response relationship between serum 25(OH)D, cadmium, CRP, and all-cause mortality. 25(oh)d 89-96 C-reactive protein Homo sapiens 107-110 35571939-9 2022 Restricted cubic splines analysis showed a significant nonlinear association between serum 25(OH)D (P-nonlinearity P < 0.001), cadmium (P-nonlinearity = 0.002), CRP (P-nonlinearity = 0.003), and HR for all-cause mortality risk in diabetic patients. 25(oh)d 91-98 C-reactive protein Homo sapiens 161-164 35474389-5 2022 STUDY SELECTION: Studies reporting on associations between rs12785878 (DHCR7), rs10741657 (CYP2R1), rs6013897 (CYP24A1) or rs2282679 (GC) and cord blood 25(OH)D. 25(oh)d 153-160 7-dehydrocholesterol reductase Homo sapiens 71-76 35474389-7 2022 DATA SYNTHESIS: Associations between both maternal and offspring SNPs at rs2282679 (GC) and rs12785878 (DHCR7) and cord blood 25(OH)D were identified. 25(oh)d 126-133 7-dehydrocholesterol reductase Homo sapiens 104-109 35629892-11 2022 CONCLUSIONS: The presence of low serum 25(OH)D concentrations after LDLT suggested that post-transplant low serum 25(OH)D concentrations may develop with the homogenous phenomenon of VDR rs2228530 and CYP2R1 rs10741657 genetic modifications in recipients regardless of graft pathology. 25(oh)d 114-121 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 201-207 35418433-8 2022 But serum 25(OH)D concentrations were associated with H. pylori CagA+ in non-Hispanic whites (adjusted OR=1.02, 95% CI: 1.00 to 1.03), other races/ethnicities (adjusted OR=1.08, 95% CI: 1.01 to 1.06), populations born in other countries (adjusted OR=1.09, 95% CI: 1.04 to 1.15) or occasional drinkers (adjusted OR=0.93, 95% CI: 0.88 to 0.99). 25(oh)d 10-17 S100 calcium binding protein A8 Homo sapiens 64-68 35565657-4 2022 Using MARS, threshold 25(OH)D levels were estimated as 17 ng/mL for calcium and 29 ng/mL for parathyroid hormone (PTH). 25(oh)d 22-29 parathyroid hormone Homo sapiens 93-112 35565657-4 2022 Using MARS, threshold 25(OH)D levels were estimated as 17 ng/mL for calcium and 29 ng/mL for parathyroid hormone (PTH). 25(oh)d 22-29 parathyroid hormone Homo sapiens 114-117 35451454-7 2022 25(OH)D had an inverse association with white matter hyperintensity volume (per 10nmol/L 25(OH)D, adjusted beta: -6.1, 95%CI -11.5, -7.0). 25(oh)d 0-7 immunoglobulin kappa variable 3D-7 Homo sapiens 87-96 35213326-6 2022 Further, the predictability of CHC on 25(OH)D levels was assessed in a multiple regression model including lifestyle factors. 25(oh)d 38-45 clathrin heavy chain Homo sapiens 31-34 35442058-10 2022 Baseline serum 25(OH)D showed a weak inverse relationship with P1NP (p = 0.036) and CTX (p = 0.221) at 12 weeks, but we observed no association between vitamin D supplementation and either BTM. 25(oh)d 15-22 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 84-87 35122787-4 2022 RESULTS: When increasing albumin concentrations were "in vitro" added, t-25(OH)D levels were overestimated by ECLPBA, and underestimated by CLIA. 25(oh)d 73-80 albumin Homo sapiens 25-32 35122787-5 2022 In patients" sera, positive correlations were detected between t-25(OH)D-vitamin D binding protein (DBP) values by both routine methods, and between t-25(OH)D-albumin values by all three methods. 25(oh)d 65-72 GC vitamin D binding protein Homo sapiens 73-98 35122787-5 2022 In patients" sera, positive correlations were detected between t-25(OH)D-vitamin D binding protein (DBP) values by both routine methods, and between t-25(OH)D-albumin values by all three methods. 25(oh)d 65-72 D-box binding PAR bZIP transcription factor Homo sapiens 100-103 35122787-5 2022 In patients" sera, positive correlations were detected between t-25(OH)D-vitamin D binding protein (DBP) values by both routine methods, and between t-25(OH)D-albumin values by all three methods. 25(oh)d 151-158 albumin Homo sapiens 159-166 35213326-1 2022 OBJECTIVE: Combined hormonal contraceptive use (CHC) has been associated with higher total 25-hydroxyvitamin D (25(OH)D) levels. 25(oh)d 112-119 clathrin heavy chain Homo sapiens 48-51 35458179-0 2022 Total 25(OH)D Concentration Moderates the Association between Caffeine Consumption and the Alkaline Phosphatase Level in Pregnant Women. 25(oh)d 6-13 alkaline phosphatase, placental Homo sapiens 91-111 35081436-7 2022 FLG expression and sensitization load were negatively correlated in non-Black participants with 25(OH)D levels < 27.2 ng/ml (Rho = -0.45; p=0.026). 25(oh)d 96-103 filaggrin Homo sapiens 0-3 35081436-9 2022 Multiple Poisson regression models confirmed that 25(OH)D levels interact with FLG expression to affect sensitization load in non-Black participants. 25(oh)d 50-57 filaggrin Homo sapiens 79-82 35450844-8 2022 25(OH)D level was positively correlated with eGFR, calcium, albumin, hemoglobin, transferrin saturation, serum iron, while a negative correlation was found with heart rate, parathormon, NT-proBNP, and CRP. 25(oh)d 0-7 epidermal growth factor receptor Homo sapiens 45-49 35450844-8 2022 25(OH)D level was positively correlated with eGFR, calcium, albumin, hemoglobin, transferrin saturation, serum iron, while a negative correlation was found with heart rate, parathormon, NT-proBNP, and CRP. 25(oh)d 0-7 albumin Homo sapiens 60-67 35450844-8 2022 25(OH)D level was positively correlated with eGFR, calcium, albumin, hemoglobin, transferrin saturation, serum iron, while a negative correlation was found with heart rate, parathormon, NT-proBNP, and CRP. 25(oh)d 0-7 transferrin Homo sapiens 81-92 35450844-8 2022 25(OH)D level was positively correlated with eGFR, calcium, albumin, hemoglobin, transferrin saturation, serum iron, while a negative correlation was found with heart rate, parathormon, NT-proBNP, and CRP. 25(oh)d 0-7 C-reactive protein Homo sapiens 201-204 35392498-7 2022 Conclusions: The serum 25(OH)D decreases notably in patients with senile T2DM, and higher serum 25(OH)D level may improve insulin resistance, limb muscle masses, and bone density and thus maintain bone health. 25(oh)d 96-103 insulin Homo sapiens 122-129 35213326-8 2022 RESULTS: CHC+ (n=64; 35% of the girls) had higher 25(OH)D levels (mean +- SD, 60.3 +-22.2) nmol/L) than CHC- (n=118; 41.8 +-19.3 nmol/L), p-values <0.01. 25(oh)d 50-57 clathrin heavy chain Homo sapiens 9-12 35213326-9 2022 The differences in 25(OH)D levels between CHC+ and CHC- was attenuated but remained significant after adjustment of lifestyle factors. 25(oh)d 19-26 clathrin heavy chain Homo sapiens 42-45 35213326-9 2022 The differences in 25(OH)D levels between CHC+ and CHC- was attenuated but remained significant after adjustment of lifestyle factors. 25(oh)d 19-26 clathrin heavy chain Homo sapiens 51-54 35509637-10 2022 Baseline total and free 25(OH)D concentrations were positively associated with 1,25(OH)2D, 24,25(OH)2D (p < 0.001), vitamin D binding protein (DBP) (p < 0.05), BMD, and BMC (p < 0.05). 25(oh)d 24-31 GC vitamin D binding protein Homo sapiens 116-141 35509637-10 2022 Baseline total and free 25(OH)D concentrations were positively associated with 1,25(OH)2D, 24,25(OH)2D (p < 0.001), vitamin D binding protein (DBP) (p < 0.05), BMD, and BMC (p < 0.05). 25(oh)d 24-31 D-box binding PAR bZIP transcription factor Homo sapiens 143-146 35509637-12 2022 After supplementation, total and free 25(OH)D concentrations remained positively associated only with 24,25(OH)2D (p < 0.001) and DBP (p < 0.001) and negatively with estimated glomerular filtration rate (eGFR) (p < 0.01). 25(oh)d 38-45 D-box binding PAR bZIP transcription factor Homo sapiens 130-133 35148277-9 2022 Multivariate regression revealed that PTH (beta: -0.23, 95% CI: -0.34, -0.13, p<0.0001) and BPA (beta: -0.25, 95% CI: -0.3, -0.19, p<0.0001) remained significantly associated with 25(OH)D levels while BPA was also associated with 1,25(OH)D levels (beta: -0.19, 95% CI: -0.22, -0.15, p<0.0001). 25(oh)d 180-187 parathyroid hormone Homo sapiens 38-41 35410821-3 2022 The serum 25(OH)D value at which parathyroid hormone level plateaus, called the "inflection point," is considered the most appropriate criterion for defining an adequate vitamin D status. 25(oh)d 10-17 parathyroid hormone Homo sapiens 33-52 35148277-9 2022 Multivariate regression revealed that PTH (beta: -0.23, 95% CI: -0.34, -0.13, p<0.0001) and BPA (beta: -0.25, 95% CI: -0.3, -0.19, p<0.0001) remained significantly associated with 25(OH)D levels while BPA was also associated with 1,25(OH)D levels (beta: -0.19, 95% CI: -0.22, -0.15, p<0.0001). 25(oh)d 232-239 parathyroid hormone Homo sapiens 38-41 35603848-3 2022 Multivariable-adjusted proportional hazards regression estimated hazard ratios (HR) and 95% confidence intervals (CI) for associations between baseline 25(OH)D concentration and subsequent cancer survival; we also stratified on the common vitamin D binding protein isoforms (Gc1f, Gc1s, and Gc2) defined by two single-nucleotide polymorphisms (rs7041 and rs4588) in the vitamin D binding protein gene GC. 25(oh)d 152-159 solute carrier family 25 member 18 Homo sapiens 291-294 35255993-1 2022 BACKGROUND: The aim of this study was to determine the 25-hydroxy vitamin D (25(OH)D) levels in age-related macular degeneration (AMD) patients. 25(oh)d 77-84 renin binding protein Homo sapiens 96-99 35603848-3 2022 Multivariable-adjusted proportional hazards regression estimated hazard ratios (HR) and 95% confidence intervals (CI) for associations between baseline 25(OH)D concentration and subsequent cancer survival; we also stratified on the common vitamin D binding protein isoforms (Gc1f, Gc1s, and Gc2) defined by two single-nucleotide polymorphisms (rs7041 and rs4588) in the vitamin D binding protein gene GC. 25(oh)d 152-159 GC vitamin D binding protein Homo sapiens 370-395 35603848-8 2022 As this was especially evident among cases with the genetically determined Gc2 isoform of vitamin D binding protein, such individuals may gain a cancer survival advantage by maintaining higher 25(OH)D blood concentrations. 25(oh)d 193-200 solute carrier family 25 member 18 Homo sapiens 75-78 35337103-7 2022 The frequency of CD3+CD4+ T helper (Th) cells was decreased in patients with 25(OH)D level <= 11.4 ng/mL, compared to healthy controls (HCs). 25(oh)d 77-84 CD4 molecule Homo sapiens 21-24 35603848-8 2022 As this was especially evident among cases with the genetically determined Gc2 isoform of vitamin D binding protein, such individuals may gain a cancer survival advantage by maintaining higher 25(OH)D blood concentrations. 25(oh)d 193-200 GC vitamin D binding protein Homo sapiens 90-115 35309153-12 2022 According to the multivariate logistic regression analysis, after adjusting for confounding factors, IL-6 (OR = 1.066, 95% CI 1.012-1.127), Alb (OR = 0.740, 95% CI 0.560-0.978), and 25(OH)D (OR = 0.798, 95% CI 0.670-0.949) were independently associated with frailty in the three groups of models. 25(oh)d 182-189 albumin Homo sapiens 140-143 35267984-0 2022 Variants in the VDR Gene May Influence 25(OH)D Levels in Type 1 Diabetes Mellitus in a Brazilian Population. 25(oh)d 39-46 vitamin D receptor Homo sapiens 16-19 35267984-9 2022 Our findings suggest that the association between 25(OH)D and T1DM may be modified by VDR variants, possibly influencing the development of this autoimmune disease. 25(oh)d 50-57 vitamin D receptor Homo sapiens 86-89 35188037-6 2022 The levels of bioavailable 25(OH)D were calculated based on the total 25(OH)D and VDBP concentrations. 25(oh)d 27-34 GC vitamin D binding protein Homo sapiens 82-86 35188037-20 2022 CONCLUSIONS: Pregnant women with the VDBP rs7041(c.1296 T > G) T allele genotype had reduced serum levels of bioavailable 25(OH)D and were more likely to develop PTL. 25(oh)d 122-129 GC vitamin D binding protein Homo sapiens 37-41 33713690-5 2021 This highly polymorphic protein is not only the major transport protein which, along with albumin, binds over 99% of the circulating vitamin D metabolites, but also participates in the transport of the 25(OH)D into the cell via a megalin/cubilin complex. 25(oh)d 202-209 albumin Homo sapiens 90-97 35223754-4 2021 Our previous studies have shown a negative correlation between insulin resistance and 25-hydroxy vitamin D (25(OH)D) levels. 25(oh)d 108-115 insulin Homo sapiens 63-70 35223754-11 2021 Conclusion: Our study demonstrates that 25(OH)D concentrations are negatively correlated with insulin resistance and bone turnover. 25(oh)d 40-47 insulin Homo sapiens 94-101 35223754-12 2021 Insulin resistance increases with the decrease of 25(OH)D concentration, which can enhance bone turnover, and increases the risk of osteoporosis in non-osteoporosis patients with T2DM. 25(oh)d 50-57 insulin Homo sapiens 0-7 35063211-9 2022 After adjustment for age, educational level, physical activity, body mass index and dietary energy intake, higher serum 25(OH)D was significantly related to a 42% decreased odds of stress (OR = 0.58, 95%CI: 0.28-0.99, p = 0.04), while, women with higher VDBP levels had an increased risk for depression (OR = 1.74, 95%CI: 1.002-3.42, p = 0.04). 25(oh)d 120-127 GC vitamin D binding protein Homo sapiens 254-258 35093020-10 2022 CONCLUSIONS: Genetically predicted increase in Vit-D status (25(OH)D) may confer secondary protection against incident combined CVD events and myocardial infarction in a hypertensive-diabetic population where serological 25(OH)D deficiency is common, through facilitating blood pressure control. 25(oh)d 61-68 vitrin Homo sapiens 47-50 35163226-2 2022 Furthermore, high DBP levels might negatively affect free 25(OH)D concentrations. 25(oh)d 58-65 D-box binding PAR bZIP transcription factor Homo sapiens 18-21 35111793-7 2021 In contrast, 25(OH)D levels were only borderline statistically significant correlated with IL-6 (r = -0.14; p <0.050). 25(oh)d 13-20 interleukin 6 Homo sapiens 91-95 35057492-3 2022 The aim of this study was to examine the relationships between serum 25(OH)D levels and glucose tolerance and insulin sensitivity in hypertension. 25(oh)d 69-76 insulin Homo sapiens 110-117 35057492-6 2022 25(OH)D levels were inversely correlated with age, blood pressure, fasting glucose, G-AUC, triglycerides, and serum calcium and PTH, while no significant relationships were found with body mass index (BMI), fasting insulin, I-AUC, HOMA index, and renal function. 25(oh)d 0-7 parathyroid hormone Homo sapiens 128-131 35057492-6 2022 25(OH)D levels were inversely correlated with age, blood pressure, fasting glucose, G-AUC, triglycerides, and serum calcium and PTH, while no significant relationships were found with body mass index (BMI), fasting insulin, I-AUC, HOMA index, and renal function. 25(oh)d 0-7 insulin Homo sapiens 215-222 35057442-2 2022 This study evaluated the association between genetic polymorphisms in GC, CYP2R1 and CYP24A1 and serum levels of total 25(OH)D, iPTH and other mineral metabolism biomarkers (albumin, total calcium and phosphorus) in a sample of 273 older Spanish adults. 25(oh)d 119-126 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 74-80 35057442-2 2022 This study evaluated the association between genetic polymorphisms in GC, CYP2R1 and CYP24A1 and serum levels of total 25(OH)D, iPTH and other mineral metabolism biomarkers (albumin, total calcium and phosphorus) in a sample of 273 older Spanish adults. 25(oh)d 119-126 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 85-92 35057442-7 2022 In conclusion, genetic variants in CYP2R1 and GC could be predictive of 25(OH)D and iPTH serum levels, respectively, in older Caucasian adults. 25(oh)d 72-79 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 35-41 34985728-3 2022 The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)D), has been shown to induce the CAMP gene expression through promoter activation. 25(oh)d 57-64 cathelicidin antimicrobial peptide Homo sapiens 96-100 34985728-5 2022 The aim of this work was to evaluate the impact of 25(OH)D supplementation on intracellular expression of CAMP and secretion of LL-37 in an ex vivo model using the peripheral blood mononuclear cells (PBMC). 25(oh)d 51-58 cathelicidin antimicrobial peptide Homo sapiens 106-110 34985728-5 2022 The aim of this work was to evaluate the impact of 25(OH)D supplementation on intracellular expression of CAMP and secretion of LL-37 in an ex vivo model using the peripheral blood mononuclear cells (PBMC). 25(oh)d 51-58 cathelicidin antimicrobial peptide Homo sapiens 128-133 34985728-9 2022 25(OH)D significantly induced CAMP gene expression at 24 h with a maximum effect at a dose of D125 in either unstimulated (tenfold expression) or stimulated (LPS: 100-fold expression; PIC: 15-fold expression) conditions. 25(oh)d 0-7 cathelicidin antimicrobial peptide Homo sapiens 30-34 34985728-11 2022 The secretion of LL-37 in the culture medium was significantly induced by 25(OH)D only in both stimulated (LPS and PIC) conditions in a dose-dependent manner. 25(oh)d 74-81 cathelicidin antimicrobial peptide Homo sapiens 17-22 34985728-12 2022 Our results demonstrate that 25(OH)D incubation increases intracellular expression of CAMP and hCAP18, but extracellular secretion of LL-37 antimicrobial peptide is increased by 25(OH)D only when PBMC from healthy donors were stimulated with bacterial or viral immune mimetic. 25(oh)d 29-36 cathelicidin antimicrobial peptide Homo sapiens 86-90 34985728-12 2022 Our results demonstrate that 25(OH)D incubation increases intracellular expression of CAMP and hCAP18, but extracellular secretion of LL-37 antimicrobial peptide is increased by 25(OH)D only when PBMC from healthy donors were stimulated with bacterial or viral immune mimetic. 25(oh)d 29-36 cathelicidin antimicrobial peptide Homo sapiens 95-101 34985728-12 2022 Our results demonstrate that 25(OH)D incubation increases intracellular expression of CAMP and hCAP18, but extracellular secretion of LL-37 antimicrobial peptide is increased by 25(OH)D only when PBMC from healthy donors were stimulated with bacterial or viral immune mimetic. 25(oh)d 29-36 cathelicidin antimicrobial peptide Homo sapiens 134-139 34985728-12 2022 Our results demonstrate that 25(OH)D incubation increases intracellular expression of CAMP and hCAP18, but extracellular secretion of LL-37 antimicrobial peptide is increased by 25(OH)D only when PBMC from healthy donors were stimulated with bacterial or viral immune mimetic. 25(oh)d 178-185 cathelicidin antimicrobial peptide Homo sapiens 134-139 35054977-6 2022 Concentration of 25(OH)D in serum of the Orx + Vit. 25(oh)d 17-24 vitrin Rattus norvegicus 47-50 34859252-5 2022 Compared with the lowest level, the highest level of 25(OH)D was significantly associated with a lower risk of GDM (RR: 0.76; 95% CI: 0.66-0.87), PE (RR: 0.74; 95% CI: 0.60-0.90;), and GH (RR: 0.87; 95% CI: 0.79-0.97); however, no significant relationship was found for C-section (RR: 1.00; 95% CI: 0.90-1.12). 25(oh)d 53-60 gamma-glutamyl hydrolase Homo sapiens 185-187 34859252-9 2022 Our meta-analysis provides further scientific evidence of the inverse association between 25(OH)D levels and the risk of GDM, PE, and GH, which may be useful for the prevention of pregnancy complications. 25(oh)d 90-97 gamma-glutamyl hydrolase Homo sapiens 134-136 2594036-3 1989 The overall inverse relation between serum parathyroid hormone and 25(OH)D levels was found to be dependent on vitamin D intake. 25(oh)d 67-74 parathyroid hormone Homo sapiens 43-62 33713690-5 2021 This highly polymorphic protein is not only the major transport protein which, along with albumin, binds over 99% of the circulating vitamin D metabolites, but also participates in the transport of the 25(OH)D into the cell via a megalin/cubilin complex. 25(oh)d 202-209 LDL receptor related protein 2 Homo sapiens 230-237 34011341-4 2021 METHODS: We measured 25-hydroxyvitamin D (25(OH)D) and typed the single nucleotide polymorphisms, rs4588 and rs7041, in the GC gene encoding the vitamin D binding protein (DBP) in 4509 children aged 0-8 years living in Kenya, Uganda, Burkina Faso, The Gambia and South Africa. 25(oh)d 42-49 GC vitamin D binding protein Homo sapiens 145-170 34032540-3 2022 Linear and multinomial logistic regression analyses were used to analyze the association of VDR single nucleotide polymorphism (SNPs) with changes in circulating 25(OH)D. 25(oh)d 162-169 vitamin D receptor Homo sapiens 92-95 34032540-4 2022 The TaqI and BsmI VDR sequence variants modified the effect of vitamin D3 treatment on the plasma 25(OH)D changes (P value = 0.008 for TaqI and P value = 0.0005 for BsmI). 25(oh)d 98-105 vitamin D receptor Homo sapiens 18-21 33662886-11 2021 In stratified analyses, the significant negative association between cord blood 25(OH)D with foetal hs-CRP and glucolipid metabolic indexes was observed only at low-medium levels of air pollution exposure. 25(oh)d 80-87 C-reactive protein Homo sapiens 103-106 33222403-9 2021 Negative correlations were observed between plasma 25(OH)D concentrations and: AAG concentrations in dogs with T-cell (Rs =-0.817, p=0.007); GM-CSF concentrations (Rs =-0.569, p=0.007) in dogs with OSA; and IL-7 concentrations (Rs =-0.548, p=0.010) in dogs with OSA. 25(oh)d 51-58 colony stimulating factor 2 Canis lupus familiaris 141-147 33222403-9 2021 Negative correlations were observed between plasma 25(OH)D concentrations and: AAG concentrations in dogs with T-cell (Rs =-0.817, p=0.007); GM-CSF concentrations (Rs =-0.569, p=0.007) in dogs with OSA; and IL-7 concentrations (Rs =-0.548, p=0.010) in dogs with OSA. 25(oh)d 51-58 interleukin 7 Canis lupus familiaris 207-211 34011380-1 2021 OBJECTIVE: Equivocal association the contribution of 25-hydroxyvitamin D (25(OH)D) and the well-accepted role of vitamin D-binding protein (VDBP) on bioavailability of 25(OH)D or its independent roles, has led to possible association of the VDBP in glucose metabolism. 25(oh)d 168-175 GC vitamin D binding protein Homo sapiens 113-138 34011380-1 2021 OBJECTIVE: Equivocal association the contribution of 25-hydroxyvitamin D (25(OH)D) and the well-accepted role of vitamin D-binding protein (VDBP) on bioavailability of 25(OH)D or its independent roles, has led to possible association of the VDBP in glucose metabolism. 25(oh)d 168-175 GC vitamin D binding protein Homo sapiens 140-144 34011380-1 2021 OBJECTIVE: Equivocal association the contribution of 25-hydroxyvitamin D (25(OH)D) and the well-accepted role of vitamin D-binding protein (VDBP) on bioavailability of 25(OH)D or its independent roles, has led to possible association of the VDBP in glucose metabolism. 25(oh)d 168-175 GC vitamin D binding protein Homo sapiens 241-245 34033278-1 2021 Objective: To evaluate the association between MetS, its components and insulin resistance (IR) with 25(OH)D and hsCRP. 25(oh)d 101-108 insulin Homo sapiens 72-79 33975017-1 2021 OBJECTIVE: Serum parathyroid hormone (PTH) and 25-hydroxyvitamin D [25(OH)D] have been demonstrated to be associated with pathogenesis and progression of osteoarthritis (OA). 25(oh)d 68-75 parathyroid hormone Homo sapiens 17-36 33975017-2 2021 This study aimed to determine the potential causal relationship between serum PTH and 25(OH)D levels and risk of OA. 25(oh)d 86-93 parathyroid hormone Homo sapiens 78-81 33847289-2 2021 Associations between vitamin D deficiency and development or progression of inflammatory bowel diseases (IBDs) are reported, but a cause-and-effect relationship between pretreatment 25 hydroxyvitamin D [25(OH)D] levels and response to anti-tumor necrosis factor-alpha (anti-TNF) therapy is not established. 25(oh)d 203-210 tumor necrosis factor Homo sapiens 240-267 33420892-10 2021 Patients with eGFR 30- < 60 mL/min/1.73m2 had significantly higher prevalence of 25(OH)D < 20 ng/mL (33.7% versus 19.4%, p < 0.05) than patients with eGFR >= 60 mL/min/1.73 m2. 25(oh)d 81-88 epidermal growth factor receptor Homo sapiens 14-18 33420892-10 2021 Patients with eGFR 30- < 60 mL/min/1.73m2 had significantly higher prevalence of 25(OH)D < 20 ng/mL (33.7% versus 19.4%, p < 0.05) than patients with eGFR >= 60 mL/min/1.73 m2. 25(oh)d 81-88 thrombopoietin Mus musculus 28-30 33420892-10 2021 Patients with eGFR 30- < 60 mL/min/1.73m2 had significantly higher prevalence of 25(OH)D < 20 ng/mL (33.7% versus 19.4%, p < 0.05) than patients with eGFR >= 60 mL/min/1.73 m2. 25(oh)d 81-88 thrombopoietin Mus musculus 97-99 33420892-10 2021 Patients with eGFR 30- < 60 mL/min/1.73m2 had significantly higher prevalence of 25(OH)D < 20 ng/mL (33.7% versus 19.4%, p < 0.05) than patients with eGFR >= 60 mL/min/1.73 m2. 25(oh)d 81-88 thrombopoietin Mus musculus 97-99 33420892-13 2021 Both decreased serum 25(OH)D levels and decreased eGFR were independently associated with increased serum PTH levels among these patients. 25(oh)d 21-28 parathyroid hormone Homo sapiens 106-109 33851280-4 2021 When comparing the CTD cohort to the unaffected cohort, the observed result was contrary to the one expected: a 10 ng/ml increase in 25(OH)D was associated with higher odds of having CTD (OR 2.08, 95% CI 1.27-3.42, p < 0.01). 25(oh)d 133-140 CTD Homo sapiens 19-22 33995282-7 2021 In adults with 25(OH)D>=12 ng/mL multiple regression models showed that serum PTH was negatively correlated with both 25(OH)D and GFR. 25(oh)d 15-22 parathyroid hormone Homo sapiens 78-81 33995282-7 2021 In adults with 25(OH)D>=12 ng/mL multiple regression models showed that serum PTH was negatively correlated with both 25(OH)D and GFR. 25(oh)d 118-125 parathyroid hormone Homo sapiens 78-81 33995282-10 2021 Increasing age was associated with higher PTH levels only in those with normal renal function and 25(OH)D>=12 ng/mL. 25(oh)d 98-105 parathyroid hormone Homo sapiens 42-45 33902533-12 2021 The serum 25(OH)D level was positively correlated with IGF-1 in women and grip strength in men. 25(oh)d 10-17 insulin like growth factor 1 Homo sapiens 55-60 33935807-2 2021 The vitamin D receptor (VDR) is present in muscle, as is CYP27B1, the enzyme that hydroxylates 25(OH)D to its active form, 1,25(OH)D. 25(oh)d 95-102 vitamin D receptor Homo sapiens 4-22 33935807-2 2021 The vitamin D receptor (VDR) is present in muscle, as is CYP27B1, the enzyme that hydroxylates 25(OH)D to its active form, 1,25(OH)D. 25(oh)d 95-102 vitamin D receptor Homo sapiens 24-27 33935807-2 2021 The vitamin D receptor (VDR) is present in muscle, as is CYP27B1, the enzyme that hydroxylates 25(OH)D to its active form, 1,25(OH)D. 25(oh)d 95-102 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 57-64 33935807-2 2021 The vitamin D receptor (VDR) is present in muscle, as is CYP27B1, the enzyme that hydroxylates 25(OH)D to its active form, 1,25(OH)D. 25(oh)d 125-132 vitamin D receptor Homo sapiens 4-22 33935807-2 2021 The vitamin D receptor (VDR) is present in muscle, as is CYP27B1, the enzyme that hydroxylates 25(OH)D to its active form, 1,25(OH)D. 25(oh)d 125-132 vitamin D receptor Homo sapiens 24-27 33935807-2 2021 The vitamin D receptor (VDR) is present in muscle, as is CYP27B1, the enzyme that hydroxylates 25(OH)D to its active form, 1,25(OH)D. 25(oh)d 125-132 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 57-64 33935976-8 2021 Both total 25(OH)D and free 25(OH)D showed significant negative correlation with FAI (rho=-0.229, p<0.0001 and rho=-0.195, p<0.0001 for total and free 25(OH)D, respectively); LH (rho=-0.177, p=0.001 and rho=-0.114, p=0.04 for total and free 25(OH)D, respectively), testosterone (rho=-0.174, p=0.001 and rho=-0.190, p<0.0001 for total and free 25(OH)D, respectively) and AMH (rho=-0.130, p=0.015 and rho=-0.107, p=0.047 for total and free 25(OH)D, respectively). 25(oh)d 11-18 anti-Mullerian hormone Homo sapiens 370-373 33935976-8 2021 Both total 25(OH)D and free 25(OH)D showed significant negative correlation with FAI (rho=-0.229, p<0.0001 and rho=-0.195, p<0.0001 for total and free 25(OH)D, respectively); LH (rho=-0.177, p=0.001 and rho=-0.114, p=0.04 for total and free 25(OH)D, respectively), testosterone (rho=-0.174, p=0.001 and rho=-0.190, p<0.0001 for total and free 25(OH)D, respectively) and AMH (rho=-0.130, p=0.015 and rho=-0.107, p=0.047 for total and free 25(OH)D, respectively). 25(oh)d 28-35 anti-Mullerian hormone Homo sapiens 370-373 33935976-8 2021 Both total 25(OH)D and free 25(OH)D showed significant negative correlation with FAI (rho=-0.229, p<0.0001 and rho=-0.195, p<0.0001 for total and free 25(OH)D, respectively); LH (rho=-0.177, p=0.001 and rho=-0.114, p=0.04 for total and free 25(OH)D, respectively), testosterone (rho=-0.174, p=0.001 and rho=-0.190, p<0.0001 for total and free 25(OH)D, respectively) and AMH (rho=-0.130, p=0.015 and rho=-0.107, p=0.047 for total and free 25(OH)D, respectively). 25(oh)d 28-35 anti-Mullerian hormone Homo sapiens 370-373 33935976-8 2021 Both total 25(OH)D and free 25(OH)D showed significant negative correlation with FAI (rho=-0.229, p<0.0001 and rho=-0.195, p<0.0001 for total and free 25(OH)D, respectively); LH (rho=-0.177, p=0.001 and rho=-0.114, p=0.04 for total and free 25(OH)D, respectively), testosterone (rho=-0.174, p=0.001 and rho=-0.190, p<0.0001 for total and free 25(OH)D, respectively) and AMH (rho=-0.130, p=0.015 and rho=-0.107, p=0.047 for total and free 25(OH)D, respectively). 25(oh)d 28-35 anti-Mullerian hormone Homo sapiens 370-373 33935976-8 2021 Both total 25(OH)D and free 25(OH)D showed significant negative correlation with FAI (rho=-0.229, p<0.0001 and rho=-0.195, p<0.0001 for total and free 25(OH)D, respectively); LH (rho=-0.177, p=0.001 and rho=-0.114, p=0.04 for total and free 25(OH)D, respectively), testosterone (rho=-0.174, p=0.001 and rho=-0.190, p<0.0001 for total and free 25(OH)D, respectively) and AMH (rho=-0.130, p=0.015 and rho=-0.107, p=0.047 for total and free 25(OH)D, respectively). 25(oh)d 28-35 anti-Mullerian hormone Homo sapiens 370-373 33935976-8 2021 Both total 25(OH)D and free 25(OH)D showed significant negative correlation with FAI (rho=-0.229, p<0.0001 and rho=-0.195, p<0.0001 for total and free 25(OH)D, respectively); LH (rho=-0.177, p=0.001 and rho=-0.114, p=0.04 for total and free 25(OH)D, respectively), testosterone (rho=-0.174, p=0.001 and rho=-0.190, p<0.0001 for total and free 25(OH)D, respectively) and AMH (rho=-0.130, p=0.015 and rho=-0.107, p=0.047 for total and free 25(OH)D, respectively). 25(oh)d 28-35 anti-Mullerian hormone Homo sapiens 370-373 33206223-9 2021 In the subjects whose 25(OH)D levels were 20 ng/ml, the levels of iPTH, Ca, P, Alb, ALP and FGF23 were 22.3 +- 9.0 pg/ml, 9.5 +- 0.4 mg/dl, 4.7 +- 0.6 mg/dl, 4.6 +- 0.3 g/dl, 920.8 +- 339.3 U/l and 42.6 +- 26.0 pg/ml, respectively. 25(oh)d 22-29 albumin Homo sapiens 81-84 33206223-9 2021 In the subjects whose 25(OH)D levels were 20 ng/ml, the levels of iPTH, Ca, P, Alb, ALP and FGF23 were 22.3 +- 9.0 pg/ml, 9.5 +- 0.4 mg/dl, 4.7 +- 0.6 mg/dl, 4.6 +- 0.3 g/dl, 920.8 +- 339.3 U/l and 42.6 +- 26.0 pg/ml, respectively. 25(oh)d 22-29 alkaline phosphatase, placental Homo sapiens 86-89 33851280-4 2021 When comparing the CTD cohort to the unaffected cohort, the observed result was contrary to the one expected: a 10 ng/ml increase in 25(OH)D was associated with higher odds of having CTD (OR 2.08, 95% CI 1.27-3.42, p < 0.01). 25(oh)d 133-140 CTD Homo sapiens 183-186 33851280-6 2021 However, a 10 ng/ml increase in 25(OH)D was associated with lower odds of having comorbid ADHD within the CTD cohort (OR 0.55, 95% CI 0.36-0.84, p = 0.01) and was inversely associated with ADHD symptom severity (beta = - 2.52, 95% CI - 4.16-0.88, p < 0.01). 25(oh)d 32-39 CTD Homo sapiens 106-109 33121835-10 2021 25(OH)D significantly directly related with white blood cells count and the different components of leukocytes formula, Neutrophils-to-Lymphocytes Ratio, Monocytes-to-Lymphocytes Ratio and C-reactive protein, but not with lymphocytes levels. 25(oh)d 0-7 C-reactive protein Homo sapiens 189-207 33867707-2 2021 This enigma of widespread VDD needs exploration especially among under-fives as physiological variations in Vitamin D Binding Protein (VDBP) levels could be potential confounders in the interpretation of total 25-hydroxyvitamin D [25(OH)D]. 25(oh)d 231-238 GC vitamin D binding protein Homo sapiens 135-139 33867707-9 2021 25(OH)D levels correlated positively with VDBP (r = 0.298, p = 0.0001). 25(oh)d 0-7 GC vitamin D binding protein Homo sapiens 42-46 33757895-2 2021 25(OH)D is a quantitatively important metabolite and widely used clinical marker of vitamin D status and is regulated by vitamin D binding protein (VDBP). 25(oh)d 0-7 GC vitamin D binding protein Homo sapiens 121-146 33880905-11 2021 RESULTS: We determined that 25(OH)D levels were lower with higher PTH levels in the group aged 9 to 14 years (pubertal children), compared to the group aged 4 to 8 (prepubertal children). 25(oh)d 28-35 parathyroid hormone Homo sapiens 66-69 33790397-10 2021 Logistic regression showed that age and SBP were risk factor of AS (OR:1.07, 95% CI: 1.05-1.10, P < 0.001; OR:1.03, 95% CI: 1.02-1.04, P < 0.001) while 25(OH)D was protective factor of AS (OR:0.987, 95% CI: 0.976-0.998, P = 0.024). 25(oh)d 152-159 selenium binding protein 1 Homo sapiens 40-43 33757895-2 2021 25(OH)D is a quantitatively important metabolite and widely used clinical marker of vitamin D status and is regulated by vitamin D binding protein (VDBP). 25(oh)d 0-7 GC vitamin D binding protein Homo sapiens 148-152 32879447-11 2021 Mean rate of change during pregnancy in 25(OH)D was directly associated with BW z-score (beta: 0.36, 95% CI 0.07; 0.65), LGA risk (IRR: 1.97, 95% CI 1.07; 3.63) and preterm birth (IRR: 7.35, 95% CI 2.99; 18.07). 25(oh)d 40-47 insulin receptor related receptor Homo sapiens 131-134 32879447-11 2021 Mean rate of change during pregnancy in 25(OH)D was directly associated with BW z-score (beta: 0.36, 95% CI 0.07; 0.65), LGA risk (IRR: 1.97, 95% CI 1.07; 3.63) and preterm birth (IRR: 7.35, 95% CI 2.99; 18.07). 25(oh)d 40-47 insulin receptor related receptor Homo sapiens 180-183 33576294-7 2021 The level of serum 25(OH)D showed a significant positive association with insulinogenic index (r = 0.147, p < .05), disposition index (r = 0.280, p < .05), and SHBG (r = 0.178, p < .05) but exhibited a negative association with HOMA-IR (r = -0.198, p < .05), FAI (r = -0.178, p < .05). 25(oh)d 19-26 sex hormone binding globulin Homo sapiens 160-164 33732216-13 2021 Serum PTH was negatively associated with 25(OH)D in basin, but not in plateau. 25(oh)d 41-48 parathyroid hormone Homo sapiens 6-9 33642417-6 2021 The inverse association between number of minor alleles of rs10500804-CYP2R1 and concentration of 25(OH)D was significant only in summer/fall. 25(oh)d 98-105 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 70-76 33642417-8 2021 In conclusion, season, dietary vitamin D intake, and four SNPs in GC, CYP2R1, and DHCR7 are independently and rs10500804-CYP2R1 is interactively associated with serum 25(OH)D concentration. 25(oh)d 167-174 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 70-76 33642417-8 2021 In conclusion, season, dietary vitamin D intake, and four SNPs in GC, CYP2R1, and DHCR7 are independently and rs10500804-CYP2R1 is interactively associated with serum 25(OH)D concentration. 25(oh)d 167-174 7-dehydrocholesterol reductase Homo sapiens 82-87 33642417-8 2021 In conclusion, season, dietary vitamin D intake, and four SNPs in GC, CYP2R1, and DHCR7 are independently and rs10500804-CYP2R1 is interactively associated with serum 25(OH)D concentration. 25(oh)d 167-174 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 121-127 33642417-9 2021 Serum 25(OH)D is influenced by genotype of rs10500804-CYP2R1 in summer/fall when sunlight exposure is high, while dietary vitamin D intake is an important determinant of serum 25(OH)D during the seasons with low cutaneous vitamin D synthesis. 25(oh)d 6-13 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 54-60 33660470-13 2021 Pearson correlation analysis revealed that serum 25(OH)D level were negatively associated with IgG and IgA antibody levels (r = -0.754 and -0.773, both P values < 0.05), and positively associated with C3 complement, CD4+ cell proportion and CD8+ cell proportion in advanced schistosomiasis patients with liver fibrosis (r = 0.827, 0.850 and 0.830, all P values < 0.05). 25(oh)d 49-56 CD4 molecule Homo sapiens 216-219 33247302-7 2021 Multivariable logistic regression was used to examine the relation between HL and total 25-hydroxyvitamin D [25(OH)D], PTH, total calcium, and BMD, adjusting for covariates. 25(oh)d 109-116 lipase C, hepatic type Homo sapiens 75-77 33247302-8 2021 RESULTS: In multivariable analyses, total 25(OH)D < 20 ng/mL was found to be associated with greater odds of low-frequency HL (OR: 2.02; 95% CI: 1.28, 3.19) and speech-frequency HL (OR: 1.96; 95% CI: 1.12, 3.44). 25(oh)d 42-49 lipase C, hepatic type Homo sapiens 123-125 33247302-8 2021 RESULTS: In multivariable analyses, total 25(OH)D < 20 ng/mL was found to be associated with greater odds of low-frequency HL (OR: 2.02; 95% CI: 1.28, 3.19) and speech-frequency HL (OR: 1.96; 95% CI: 1.12, 3.44). 25(oh)d 42-49 lipase C, hepatic type Homo sapiens 178-180 33660470-13 2021 Pearson correlation analysis revealed that serum 25(OH)D level were negatively associated with IgG and IgA antibody levels (r = -0.754 and -0.773, both P values < 0.05), and positively associated with C3 complement, CD4+ cell proportion and CD8+ cell proportion in advanced schistosomiasis patients with liver fibrosis (r = 0.827, 0.850 and 0.830, all P values < 0.05). 25(oh)d 49-56 CD8a molecule Homo sapiens 241-244 33168652-7 2021 Higher serum 25(OH)D levels were significantly associated with lower levels of glucose, insulin, HOMA of insulin resistance, HbA1c, blood lipids, and C-reactive protein at baseline (all P trend < 0.05). 25(oh)d 13-20 insulin Homo sapiens 88-95 33168652-7 2021 Higher serum 25(OH)D levels were significantly associated with lower levels of glucose, insulin, HOMA of insulin resistance, HbA1c, blood lipids, and C-reactive protein at baseline (all P trend < 0.05). 25(oh)d 13-20 insulin Homo sapiens 105-112 33168652-7 2021 Higher serum 25(OH)D levels were significantly associated with lower levels of glucose, insulin, HOMA of insulin resistance, HbA1c, blood lipids, and C-reactive protein at baseline (all P trend < 0.05). 25(oh)d 13-20 C-reactive protein Homo sapiens 150-168 33382404-8 2021 RESULTS: GC vitamin D-binding protein and cytochrome P450 family 2 subfamily R polypeptide 1 genes showed genome-wide significant associations with serum 25(OH)D concentration. 25(oh)d 154-161 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 42-92 32703720-10 2021 Post hoc analysis of absolute changes indicated vit D pill and SOA + vit D + essential oil had significant increases (p < 0.05) in serum 25(OH)D compared to all other interventions with no significant difference between them. 25(oh)d 137-144 vitrin Homo sapiens 48-51 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 transforming growth factor alpha Homo sapiens 245-253 32311700-6 2021 RESULTS: Baseline TGF-beta and second and third trimesters IFN-beta and IL-2 were associated with baseline 25(OH)D. 25(oh)d 107-114 transforming growth factor alpha Homo sapiens 18-26 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 interferon gamma Homo sapiens 263-272 32311700-6 2021 RESULTS: Baseline TGF-beta and second and third trimesters IFN-beta and IL-2 were associated with baseline 25(OH)D. 25(oh)d 107-114 interferon alpha 2 Homo sapiens 59-67 32311700-6 2021 RESULTS: Baseline TGF-beta and second and third trimesters IFN-beta and IL-2 were associated with baseline 25(OH)D. 25(oh)d 107-114 interleukin 2 Homo sapiens 72-76 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 interleukin 2 Homo sapiens 277-281 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 interferon gamma Homo sapiens 322-331 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 C-reactive protein Homo sapiens 333-336 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 transforming growth factor alpha Homo sapiens 338-346 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 tumor necrosis factor Homo sapiens 348-357 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 vascular endothelial growth factor A Homo sapiens 359-363 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 interleukin 2 Homo sapiens 365-369 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 interleukin 4 Homo sapiens 375-379 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 transforming growth factor alpha Homo sapiens 338-346 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 vascular endothelial growth factor A Homo sapiens 947-951 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 interleukin 10 Homo sapiens 957-962 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 interleukin 10 Homo sapiens 972-977 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 transforming growth factor alpha Homo sapiens 245-253 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 interferon gamma Homo sapiens 263-272 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 interleukin 2 Homo sapiens 277-281 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 interferon gamma Homo sapiens 322-331 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 C-reactive protein Homo sapiens 333-336 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 transforming growth factor alpha Homo sapiens 338-346 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 tumor necrosis factor Homo sapiens 348-357 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 vascular endothelial growth factor A Homo sapiens 359-363 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 interleukin 2 Homo sapiens 365-369 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 interleukin 4 Homo sapiens 375-379 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 transforming growth factor alpha Homo sapiens 338-346 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 vascular endothelial growth factor A Homo sapiens 947-951 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 interleukin 10 Homo sapiens 957-962 32311700-12 2021 IMPACT: In this vitamin D supplementation clinical trial, baseline (first trimester) but not increasing plasma 25(OH)D concentration impacted select plasma immune-mediator profiles in pregnant women.Baseline 25(OH)D was associated with baseline TGF-beta and with IFN-gamma and IL-2 at second and third trimesters.Baseline IFN-gamma, CRP, TGF-beta, TNF-alpha, VEGF, IL-2, and IL-4 were associated with concentrations at second and third trimesters for respective immune-mediators; however, 25(OH)D concentration at second and third trimesters were not.Some racial differences existed in immune-mediator concentrations at baseline and at second and third trimesters.This study assesses the impact of vitamin D supplementation on multiple immune-mediators in pregnant women of different racial/ethnic groups using longitudinal data from a relatively large randomized controlled trial.This study found that race was associated with baseline TGF-beta, VEGF, and IL-10 and with IL-10 at second and third trimesters, a novel finding that sheds light where relationships were less well defined.The results of this study suggest that vitamin D supplementation before conception or early in pregnancy, rather than during pregnancy, may be necessary to significantly impact immune-mediator response.This study sets premise for future clinical trials to evaluate the effect of vitamin D supplementation before conception or prior to pregnancy. 25(oh)d 208-215 interleukin 10 Homo sapiens 972-977 33188595-1 2021 BACKGROUND: 25-Hydroxyvitamin D [25(OH)D] may be a poor marker of vitamin D status as it reflects differences in vitamin D binding protein (VDBP) between individuals. 25(oh)d 33-40 GC vitamin D binding protein Homo sapiens 113-138 33188595-1 2021 BACKGROUND: 25-Hydroxyvitamin D [25(OH)D] may be a poor marker of vitamin D status as it reflects differences in vitamin D binding protein (VDBP) between individuals. 25(oh)d 33-40 GC vitamin D binding protein Homo sapiens 140-144 33584542-3 2020 However, most of the circulating 25(OH)D is bound to either VitD-binding protein (VDBP) (88%) or albumin (12%) and less than 1% circulates free. 25(oh)d 33-40 GC vitamin D binding protein Homo sapiens 60-80 33572979-8 2021 The homozygous rare CC genotype of rs9533156 (RANKL) was associated with lower 25(OH)D levels in CTRs (p = 0.032). 25(oh)d 79-86 TNF superfamily member 11 Homo sapiens 46-51 33572979-9 2021 In contrast, heterozygous AG genotype of rs2277438 (RANKL) is associated with lower 25(OH)D in the OP group (p = 0.02). 25(oh)d 84-91 TNF superfamily member 11 Homo sapiens 52-57 33572979-10 2021 Our results suggest that RANKL SNPs may impact 25(OH)D levels and that OPG SNP rs2073618A/G is a significant genetic risk factor for PMO Saudi Arabian women. 25(oh)d 47-54 TNF superfamily member 11 Homo sapiens 25-30 33572874-11 2021 In conclusion, these results indicate that the maternal TAQI VDR polymorphism significantly affected neonatal birth anthropometry when maternal 25(OH) concentrations were <50 nmol/L, but not for a higher cut-off of >50 nmol/L, whereas this effect is minimally evident in the presence of neonatal TAQI polymorphism with neonatal 25(OH)D values <25 nmol/L. 25(oh)d 328-335 vitamin D receptor Homo sapiens 61-64 33572874-12 2021 The implication of these findings could be incorporated in daily clinical practice by targeting a maternal 25(OH)D cut-off >50 nmol/L, which could be protective against any effect of genetic VDR variance polymorphism on birth anthropometry. 25(oh)d 107-114 vitamin D receptor Homo sapiens 191-194 33584542-3 2020 However, most of the circulating 25(OH)D is bound to either VitD-binding protein (VDBP) (88%) or albumin (12%) and less than 1% circulates free. 25(oh)d 33-40 GC vitamin D binding protein Homo sapiens 82-86 33413064-9 2022 In addition, a correlation between 25(OH)D levels with HbA1c and total insulin dose at the end of the study was observed (r = -0.3, p<0.05; r=-0.4, p<0.05, respectively) and a regression model demonstrated that 25(OH)D was independent of BMI, duration of T1DM and final total insulin dose, being capable of determining 9.2% of HbA1c final levels (Unstandardized B coefficient = -0.033 (CI 95%: -0.064 to -0.002), r2 = 0.1, p <0.05). 25(oh)d 35-42 insulin Homo sapiens 71-78 33468272-4 2021 We used data from National Health and Nutrition Examination Survey (2005-2010), to evaluate the associations between serum 25(OH)D and markers of insulin resistance or inflammation, and whether these associations are mediated by adiposity factors including body mass index (BMI, marker of body adiposity), waist circumference (WC, marker of central adiposity), anthropometrically predicted visceral adipose tissue (apVAT), and Visceral Adiposity Index (VAI). 25(oh)d 123-130 insulin Homo sapiens 146-153 33468272-9 2021 Body mass index (BMI) was found to have significant mediation effects (to varied extent) on the associations between serum 25(OH)D and CRP, apo-B, fasting glucose, insulin, HOMA-IR, HOMA-B and HbA1c (all p<0.05). 25(oh)d 123-130 C-reactive protein Homo sapiens 135-138 33468272-10 2021 Both waist circumference and apVAT were also found to partly mediate the associations between serum 25(OH)D with CRP, FBG, HbA1c, triglycerides and HDL-cholesterol (all P < 0.05). 25(oh)d 100-107 C-reactive protein Homo sapiens 113-116 33468272-12 2021 Using a mediation model, our findings suggest that the relationship between serum 25(OH)D, insulin resistance and inflammation, may be in part mediated by adiposity. 25(oh)d 82-89 insulin Homo sapiens 91-98 33452895-11 2021 Significant increases in VDR expression and CSA were observed in vitamin D-deficient patients [25(OH)D] < 20 ng/mL, but not in vitamin D-non-deficient patients. 25(oh)d 95-102 vitamin D receptor Homo sapiens 25-28 33452895-11 2021 Significant increases in VDR expression and CSA were observed in vitamin D-deficient patients [25(OH)D] < 20 ng/mL, but not in vitamin D-non-deficient patients. 25(oh)d 95-102 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 44-47 33413064-9 2022 In addition, a correlation between 25(OH)D levels with HbA1c and total insulin dose at the end of the study was observed (r = -0.3, p<0.05; r=-0.4, p<0.05, respectively) and a regression model demonstrated that 25(OH)D was independent of BMI, duration of T1DM and final total insulin dose, being capable of determining 9.2% of HbA1c final levels (Unstandardized B coefficient = -0.033 (CI 95%: -0.064 to -0.002), r2 = 0.1, p <0.05). 25(oh)d 35-42 insulin Homo sapiens 276-283 33413064-9 2022 In addition, a correlation between 25(OH)D levels with HbA1c and total insulin dose at the end of the study was observed (r = -0.3, p<0.05; r=-0.4, p<0.05, respectively) and a regression model demonstrated that 25(OH)D was independent of BMI, duration of T1DM and final total insulin dose, being capable of determining 9.2% of HbA1c final levels (Unstandardized B coefficient = -0.033 (CI 95%: -0.064 to -0.002), r2 = 0.1, p <0.05). 25(oh)d 211-218 insulin Homo sapiens 71-78 33115916-9 2021 Mean 25(OH)D clearances were 360 ml/d, 313 ml/d, and 263 ml/d in participants with normal eGFR, CKD, and kidney failure, respectively (P=0.02). 25(oh)d 5-12 epidermal growth factor receptor Homo sapiens 90-94 32446789-9 2021 Besides, DLBCL patients with higher total or bioavailable 25(OH)D levels were more sensitive to the R-CHOP regimen treatments. 25(oh)d 58-65 DNA damage inducible transcript 3 Homo sapiens 102-106 33022030-3 2021 RESULTS: PTH levels were higher in Black Americans (BA) than White Americans (WA) at all levels of 25(OH)D and across eGFR strata. 25(oh)d 99-106 parathyroid hormone Homo sapiens 9-12 33022030-4 2021 There was a progressive decline in PTH levels from the lowest (25(OH)D < 20) to highest quartile (25(OH)D >=40) in both BA (134.4 v 90 pg/mL, respectively) and WA (112.5 v 71.62 pg/mL) (p<0.001 for all comparisons). 25(oh)d 63-70 parathyroid hormone Homo sapiens 35-38 33022030-4 2021 There was a progressive decline in PTH levels from the lowest (25(OH)D < 20) to highest quartile (25(OH)D >=40) in both BA (134.4 v 90 pg/mL, respectively) and WA (112.5 v 71.62 pg/mL) (p<0.001 for all comparisons). 25(oh)d 98-105 parathyroid hormone Homo sapiens 35-38 33022030-5 2021 CONCLUSION: In this analysis, higher than normal 25(OH)D levels were well tolerated and associated with lower parathyroid hormone values in both blacks and whites. 25(oh)d 49-56 parathyroid hormone Homo sapiens 110-129 33687883-9 2021 Serum 25(OH)D was positively correlated with BMD (lumbar and femoral; p=0.002 and p=0.01 respectively) and Z scores (lumbar and femoral; p<0.001and p=0.01 respectively), whereas, negatively correlated with ASDAS-CRP (p<0.001), BASFI (p<0.001), mSASSS (p=0.003). 25(oh)d 6-13 C-reactive protein Homo sapiens 212-215 33106256-6 2021 Plasma ascorbic acid and 25(OH)D at infancy were lower in HLA-DR3/DR4 children among IA cases but not in matched controls, implying gene expression dysregulation of circulating vitamins as latent signals for IA or T1D progression. 25(oh)d 25-32 major histocompatibility complex, class II, DR beta 4 Homo sapiens 66-69 33626316-5 2021 In liver, CYP2R1 25-hydroxylates vitamin D and serves as an important determinant of 25(OH)D level in the tissue and in circulation. 25(oh)d 85-92 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 10-16 33115916-10 2021 After adjustment for age, sex, race, and estimated blood volume, lower eGFR was associated with reduced 25(OH)D clearance (beta=-17 ml/d per 10 ml/min per 1.73 m2 lower eGFR; 95% CI, -21 to -12). 25(oh)d 104-111 epidermal growth factor receptor Homo sapiens 71-75 33115916-10 2021 After adjustment for age, sex, race, and estimated blood volume, lower eGFR was associated with reduced 25(OH)D clearance (beta=-17 ml/d per 10 ml/min per 1.73 m2 lower eGFR; 95% CI, -21 to -12). 25(oh)d 104-111 epidermal growth factor receptor Homo sapiens 169-173 33115916-11 2021 Black race was associated with higher 25(OH)D clearance in participants with normal eGFR, but not in those with CKD or kidney failure (P for interaction=0.05). 25(oh)d 38-45 epidermal growth factor receptor Homo sapiens 84-88 33740328-14 2021 In children with hyperglycemia and insulin resistance, 25(OH)D levels were significantly lower compared with those who had normal glycemic parameters and HOMA-IR index. 25(oh)d 55-62 insulin Homo sapiens 35-42 32616391-13 2020 Serum 25(OH)D levels showed a negative correlation with insulin and HOMA-IR. 25(oh)d 6-13 insulin Homo sapiens 56-63 34019351-15 2021 The concentration of PTH in all children was within the physiological norm, while there was a moderate negative correlation between the levels of PTH and 25(OH)D (r=-0.44, p<0.05). 25(oh)d 154-161 parathyroid hormone Homo sapiens 146-149 33423808-7 2021 The mutations of above seven SNPs, except for rs1155563, were also respectively associated with lower 25(OH)D in the second trimester, but to a lesser extent; Besides, pregnant women with mutation on CYP24A1-rs2209314 had a higher increment in 25(OH)D than their counterparts in the second trimester. 25(oh)d 102-109 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 200-207 33423808-7 2021 The mutations of above seven SNPs, except for rs1155563, were also respectively associated with lower 25(OH)D in the second trimester, but to a lesser extent; Besides, pregnant women with mutation on CYP24A1-rs2209314 had a higher increment in 25(OH)D than their counterparts in the second trimester. 25(oh)d 244-251 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 200-207 33423808-9 2021 The associations of GC and LRP2 genes with 25(OH)D modified by season and VD supplements. 25(oh)d 43-50 LDL receptor related protein 2 Homo sapiens 27-31 33353437-5 2022 In the patient group, elevated levels of IFN-gamma, IL-17A, and IL-10 had a significant association with the serum levels of 25(OH)D, while the levels of TGF-beta, IL-6, and TNF-alpha showed an insignificant association. 25(oh)d 125-132 interferon gamma Homo sapiens 41-50 33353437-5 2022 In the patient group, elevated levels of IFN-gamma, IL-17A, and IL-10 had a significant association with the serum levels of 25(OH)D, while the levels of TGF-beta, IL-6, and TNF-alpha showed an insignificant association. 25(oh)d 125-132 interleukin 17A Homo sapiens 52-58 33353437-5 2022 In the patient group, elevated levels of IFN-gamma, IL-17A, and IL-10 had a significant association with the serum levels of 25(OH)D, while the levels of TGF-beta, IL-6, and TNF-alpha showed an insignificant association. 25(oh)d 125-132 interleukin 10 Homo sapiens 64-69 32713029-10 2020 Pearson"s correlation analysis demonstrated that the maternal 25(OH)D level was negatively correlated with maternal plasma glucose, insulin, LDL-C, cholesterol, triglyceride, and HOMA-IR (r = -0.38, -0.27, -0.2, -0.11, -0.11, -0.33, and 0.11; P < 0.01, < 0.01, < 0.01, < 0.05, < 0.05, and < 0.01, respectively), while there was a positive correlation between maternal serum 25(OH)D and HOMA-S (r = 0.11, P < 0.05). 25(oh)d 62-69 insulin Homo sapiens 132-139 32844222-2 2020 The aim of this study was to assess the correlation between blood serum 25(OH)D levels and Th17 and Treg circulating subsets, mainly Treg/ICOS + which seems to have a protective role in autoimmunity, in children with T1D and their healthy siblings (S). 25(oh)d 72-79 inducible T cell costimulator Homo sapiens 138-142 32844222-9 2020 S subjects with 25(OH)D levels &25 nmol/L had Th17, Treg (p&0.01) and Treg/ICOS + (p&0.05) percentages higher than subjects with 25(OH)D >75 nmol/L. 25(oh)d 16-23 inducible T cell costimulator Homo sapiens 75-79 32844222-11 2020 At baseline, in S subjects, a decreasing trend in Th17 and Treg/ICOS + values (p&0.05) from vitamin D deficiency to sufficiency was observed; 25(OH)D levels were negative predictors of Treg/ICOS + (R-square: 0.301) and Th17 percentages (R-square: 0.138). 25(oh)d 142-149 inducible T cell costimulator Homo sapiens 190-194 33396337-3 2020 Evidence suggests that bioavailable 25(OH)D may be a better indicator of Vitamin D compared to total 25(OH)D due to its weak bind to albumin, increasing its "availability". 25(oh)d 36-43 albumin Homo sapiens 133-140 33396337-8 2020 VDBP level was significantly correlated with bioavailable 25(OH)D level, but not with the total 25(OH)D level. 25(oh)d 58-65 GC vitamin D binding protein Homo sapiens 0-4 33372187-6 2020 Besides serum vitamin D levels (25(OH)D), a functional polymorphism (rs4588) of the vitamin D-binding protein is used as a proxy for 25(OH)D. 25(oh)d 133-140 GC vitamin D binding protein Homo sapiens 84-109 33340057-9 2022 A negative correlation was observed between 25(OH)D and 25(OH)D3 serum levels and Birmingham vasculitis activity score (BVAS), C-reactive protein (CRP), and white blood cell count. 25(oh)d 44-51 C-reactive protein Homo sapiens 127-145 33340057-9 2022 A negative correlation was observed between 25(OH)D and 25(OH)D3 serum levels and Birmingham vasculitis activity score (BVAS), C-reactive protein (CRP), and white blood cell count. 25(oh)d 44-51 C-reactive protein Homo sapiens 147-150 33340057-10 2022 Linear regression analysis indicated haemoglobin and 25(OH)D levels to be independently associated with BVAS and CRP and 25(OH)D levels with SF-36 MCS score. 25(oh)d 53-60 C-reactive protein Homo sapiens 113-116 33276664-2 2020 We investigated the cross-sectional associations between vitamin D status as assessed by serum 25(OH)D and GGT. 25(oh)d 95-102 gamma-glutamyltransferase light chain family member 3 Homo sapiens 107-110 33276664-7 2020 GGT was inversely correlated with 25(OH)D concentrations (R = -0.23; p = 0.002). 25(oh)d 34-41 gamma-glutamyltransferase light chain family member 3 Homo sapiens 0-3 33276664-9 2020 Higher leukocyte and neutrophil counts and lower 25(OH)D concentration were found in patients with GGT > 19 U/L. 25(oh)d 49-56 gamma-glutamyltransferase light chain family member 3 Homo sapiens 99-102 33276664-10 2020 CONCLUSIONS: We identified an interaction between declining 25(OH)D levels and rising GGT levels with increasing age, which resulted in an unfavorable 25(OH)D-to-GGT ratio in stable CAD patients. 25(oh)d 60-67 gamma-glutamyltransferase light chain family member 3 Homo sapiens 162-165 33276664-10 2020 CONCLUSIONS: We identified an interaction between declining 25(OH)D levels and rising GGT levels with increasing age, which resulted in an unfavorable 25(OH)D-to-GGT ratio in stable CAD patients. 25(oh)d 151-158 gamma-glutamyltransferase light chain family member 3 Homo sapiens 86-89 33276664-10 2020 CONCLUSIONS: We identified an interaction between declining 25(OH)D levels and rising GGT levels with increasing age, which resulted in an unfavorable 25(OH)D-to-GGT ratio in stable CAD patients. 25(oh)d 151-158 gamma-glutamyltransferase light chain family member 3 Homo sapiens 162-165 32616391-14 2020 Serum 25(OH)D is associated with insulin resistance independently of obesity. 25(oh)d 6-13 insulin Homo sapiens 33-40 33218348-0 2020 The association between anti-Mullerian hormone and vitamin 25(OH)D serum levels and polycystic ovarian syndrome in adolescent females. 25(oh)d 59-66 anti-Mullerian hormone Homo sapiens 24-46 32981799-6 2020 Changes of insulin resistance markers were associated with changes of total body fat mass (TBF%), 25(OH)D, and ferritin. 25(oh)d 98-105 insulin Homo sapiens 11-18 33239907-12 2020 A one-way analysis of covariance was performed to compare 25(OH)D concentrations between the subjects with and without CP in each drinking group, and the serum 25(OH)D levels of subjects with CP were significantly lower than those without CP among drinkers (p = 0.007). 25(oh)d 160-167 ceruloplasmin Homo sapiens 192-194 32937653-11 2020 RESULTS: After 4-y follow-up, deficient serum 25(OH)D was a risk factor for the incidence of BADL disability in both women (IRR: 1.53; 95% CI: 1.16, 2.03) and men (IRR: 1.44; 95% CI: 1.02, 2.02). 25(oh)d 46-53 insulin receptor related receptor Homo sapiens 124-127 32937653-11 2020 RESULTS: After 4-y follow-up, deficient serum 25(OH)D was a risk factor for the incidence of BADL disability in both women (IRR: 1.53; 95% CI: 1.16, 2.03) and men (IRR: 1.44; 95% CI: 1.02, 2.02). 25(oh)d 46-53 insulin receptor related receptor Homo sapiens 164-167 33330279-7 2020 We also analyzed the influence of exogenous factors on the level of 25(OH)D in children of the three study regions, as well as the relationship of the level of 25(OH)D with variants CYP2C9 * 2 (c.430C>T; R144C), CYP2C9 * 3 (c,1075A>C; I359L), CYP2D6 * 4 (1846G>A), CYP3A4 * 3 (c.1334T>C), and CYP3A4 * 1B (c.-392C>T) and rs731236, rs2228570 and rs1544410 in the VDR gene. 25(oh)d 160-167 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 182-188 33239907-1 2020 Purpose: Although the explanation for inconsistencies in the reported association between serum 25-hydroxyvitamin D [25(OH)D] levels and chronic pain (CP) has not yet been determined, understanding this discrepancy is necessary for the development of vitamin D supplementation as an effective treatment for CP. 25(oh)d 117-124 ceruloplasmin Homo sapiens 151-153 33239907-13 2020 A logistic regression analysis revealed a correlation between serum 25(OH)D deficiency and CP in drinkers after adjustments for several confounding factors (odds ratio: 0.499; 95% confidence interval: 0.268 - 0.927; p = 0.028). 25(oh)d 68-75 ceruloplasmin Homo sapiens 91-93 33239907-2 2020 The aim of this cross-sectional study was to examine the relationship between 25(OH)D concentrations and CP according to drinking habits in Japanese subjects. 25(oh)d 78-85 ceruloplasmin Homo sapiens 105-107 33239907-11 2020 A significant interaction between CP and drinking habits on 25(OH)D concentrations was observed (p = 0.098). 25(oh)d 60-67 ceruloplasmin Homo sapiens 34-36 33239907-14 2020 Conclusion: The present results suggest that low serum 25(OH)D concentrations are associated with the development of CP in drinkers. 25(oh)d 55-62 ceruloplasmin Homo sapiens 117-119 33239907-12 2020 A one-way analysis of covariance was performed to compare 25(OH)D concentrations between the subjects with and without CP in each drinking group, and the serum 25(OH)D levels of subjects with CP were significantly lower than those without CP among drinkers (p = 0.007). 25(oh)d 160-167 ceruloplasmin Homo sapiens 192-194 32391587-2 2020 However, it is unknown whether this association differs by the vitamin D-binding protein (GC) isoform Gc2 (encoded by GC rs4588*C>A, Thr436Lys), which may substantially affect vitamin D metabolism and modify associations of 25(OH)D with colorectal neoplasm risk. 25(oh)d 224-231 GC vitamin D binding protein Homo sapiens 63-88 33205195-9 2021 Associations were stronger and significant restricting to 14 hrHPV types (25(OH)D per 10ng/mL increase: aOR=1.82,95%CI:1.15-2.88 and aOR=4.19,95%CI:1.18-14.88 DBP-adjusted; 25(OH)D>=30 vs <30ng/mL: aOR=8.85,95%CI:2.69-29.06; 24,25(OH)2D: aOR=1.85,95%CI:1.18-2.88). 25(oh)d 74-81 D-box binding PAR bZIP transcription factor Homo sapiens 159-162 32391587-2 2020 However, it is unknown whether this association differs by the vitamin D-binding protein (GC) isoform Gc2 (encoded by GC rs4588*C>A, Thr436Lys), which may substantially affect vitamin D metabolism and modify associations of 25(OH)D with colorectal neoplasm risk. 25(oh)d 224-231 solute carrier family 25 member 18 Homo sapiens 102-105 32391587-5 2020 In the pooled analysis, multivariable-adjusted hazard ratios (HRs) for CRC-specific mortality associated with deficient relative to sufficient 25(OH)D concentrations were 2.24 (95% CI 1.44-3.49) among cases with the Gc2 isoform, and 0.94 (95% CI 0.68-1.22) among cases without Gc2 (Pinteraction = 0.0002). 25(oh)d 143-150 solute carrier family 25 member 18 Homo sapiens 216-219 32391587-7 2020 Our findings suggest that the association of pre-diagnostic vitamin D status with mortality among CRC patients may differ by functional GC isoforms, and patients who inherit the Gc2 isoform (GC rs4588*A) may particularly benefit from higher circulating 25(OH)D for improved CRC prognosis. 25(oh)d 253-260 solute carrier family 25 member 18 Homo sapiens 178-181 33151930-9 2020 Furthermore, the serum total 25(OH)D level was positively correlated with the serum albumin level and prothrombin time and negatively correlated with the serum total bilirubin level and necroinflammatory activity in AIH. 25(oh)d 29-36 albumin Homo sapiens 78-91 33190990-6 2021 The associations between 25(OH)D and CRC risk significantly differed by PTH levels, particularly among women. 25(oh)d 25-32 parathyroid hormone Homo sapiens 72-75 33151930-11 2020 Interestingly, AIH patients with serum total 25(OH)D levels of < 15 ng/mL had higher levels of inflammatory cytokines such as interferon-gamma and interleukin-33. 25(oh)d 45-52 interferon gamma Homo sapiens 126-142 33151930-11 2020 Interestingly, AIH patients with serum total 25(OH)D levels of < 15 ng/mL had higher levels of inflammatory cytokines such as interferon-gamma and interleukin-33. 25(oh)d 45-52 interleukin 33 Homo sapiens 147-161 32710436-8 2020 For postmenopausal subjects, Klotho levels had positive correlation with levels of iPTH (r = 0.25, p = 0.026) and corrected calcium (r = 0.34, p = 0.003), but negative correlation with 25(OH)D (r = -0.23, p = 0.042). 25(oh)d 185-192 klotho Homo sapiens 29-35 33177853-1 2020 Purpose: The aim was to evaluate 25(OH)D serum concentrations in metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO) and its relation with biochemical and clinical parameters in both groups according to homeostatic model assessment-insulin resistance (HOMA-IR) definition of the obesity phenotypes. 25(oh)d 33-40 insulin Homo sapiens 259-266 32926956-6 2020 RESULTS: Compared with the NC group, serum 25(OH)D level decreased in DM group (25.39 +- 4.94 ng/mL vs 19.43 +- 5.98 ng/mL) and significantly decreased in DM1 and DM2 group (14.22 +- 5.64 ng/mL vs 17.36 +- 6.25 ng/mL). 25(oh)d 43-50 immunoglobulin heavy diversity 1-14 (non-functional) Homo sapiens 163-166 32926956-7 2020 However, the level of serum 25(OH)D in the DM2 group was higher than that in the DM1 group. 25(oh)d 28-35 immunoglobulin heavy diversity 1-14 (non-functional) Homo sapiens 43-46 32933052-8 2020 Factors influencing vitamin D concentration, including socio-demographic and biochemical factors as well as the genetic polymorphism of the vitamin D receptor, along with vitamin D transporters and enzymes participating in vitamin D metabolism should be considered as potential confounders of the interpretation of plasma total 25(OH)D concentrations. 25(oh)d 328-335 vitamin D receptor Homo sapiens 140-158 33038456-9 2020 We observed a negative correlation between BMI, WC, insulin, HOMA, and PA. We determined that there is a negative association between leptin and vitamin 25(OH)D concentrations (P = 0.007) and a positive association with adiponectin (P = 0.014). 25(oh)d 153-160 leptin Homo sapiens 134-140 33065276-10 2020 There were significant negative correlations between 25(OH)D with LPER, SOST, and hepicidin. 25(oh)d 53-60 sclerostin Homo sapiens 72-76 32576302-3 2020 Multivariate logistic regression and linear regression were applied to assess the associations between serum 25(OH)D levels and ALT, AST, ALP and GGT concentrations. 25(oh)d 109-116 solute carrier family 17 member 5 Homo sapiens 133-136 32576302-3 2020 Multivariate logistic regression and linear regression were applied to assess the associations between serum 25(OH)D levels and ALT, AST, ALP and GGT concentrations. 25(oh)d 109-116 alkaline phosphatase, placental Homo sapiens 138-141 32576302-3 2020 Multivariate logistic regression and linear regression were applied to assess the associations between serum 25(OH)D levels and ALT, AST, ALP and GGT concentrations. 25(oh)d 109-116 gamma-glutamyltransferase 2, pseudogene Homo sapiens 146-149 32576302-6 2020 RESULTS: We found a significant association between low serum 25(OH)D levels (<30 nmol/l) and ALP levels in all participants (OR 2 67; 95 % CI 1 98, 3 59; P < 0 001), a confirmed healthy population (OR 3 02; 95 % CI 2 25, 4 07; P < 0 001) and individuals with viral hepatitis (OR 2 87; 95 % CI 1 52, 5 44; P = 0 006) compared with those who had normal 25(OH)D levels (>50 nmol/l). 25(oh)d 62-69 alkaline phosphatase, placental Homo sapiens 94-97 32576302-6 2020 RESULTS: We found a significant association between low serum 25(OH)D levels (<30 nmol/l) and ALP levels in all participants (OR 2 67; 95 % CI 1 98, 3 59; P < 0 001), a confirmed healthy population (OR 3 02; 95 % CI 2 25, 4 07; P < 0 001) and individuals with viral hepatitis (OR 2 87; 95 % CI 1 52, 5 44; P = 0 006) compared with those who had normal 25(OH)D levels (>50 nmol/l). 25(oh)d 352-359 alkaline phosphatase, placental Homo sapiens 94-97 32576302-7 2020 Moreover, in both the logistic regression and linear regression, the associations between 25(OH)D levels and ALP levels were stronger in the subgroups with obesity. 25(oh)d 90-97 alkaline phosphatase, placental Homo sapiens 109-112 33109180-7 2020 RESULTS: The breakpoint for the parathyroid hormone concentration occurred at a 25(OH)D concentration of 17 ng/mL, whereas the cortical bone density breakpoint occurred at a 25-hydroxyvitamin D concentration of 19 ng/mL. 25(oh)d 80-87 parathyroid hormone Oryctolagus cuniculus 32-51 33210066-10 2020 Finally, in individuals with PHP, significant correlations (p < 0.01) were documented between PTH and calcium (r = 0.74), 25OHD (r = -0.43), 1,25(OH)D (r = 0.52), and 1,25(OH)D/25OHD (r = 0.46); and between 1,25(OH)D/25OHD and calcium (r = 0.47). 25(oh)d 143-150 parathyroid hormone Homo sapiens 94-97 33210066-10 2020 Finally, in individuals with PHP, significant correlations (p < 0.01) were documented between PTH and calcium (r = 0.74), 25OHD (r = -0.43), 1,25(OH)D (r = 0.52), and 1,25(OH)D/25OHD (r = 0.46); and between 1,25(OH)D/25OHD and calcium (r = 0.47). 25(oh)d 169-176 parathyroid hormone Homo sapiens 94-97 33210066-10 2020 Finally, in individuals with PHP, significant correlations (p < 0.01) were documented between PTH and calcium (r = 0.74), 25OHD (r = -0.43), 1,25(OH)D (r = 0.52), and 1,25(OH)D/25OHD (r = 0.46); and between 1,25(OH)D/25OHD and calcium (r = 0.47). 25(oh)d 169-176 parathyroid hormone Homo sapiens 94-97 33471654-8 2020 Although endogenous 25(OH)D3 levels were reduced by IM D2, the total 25(OH)D levels increased by 5.0, 7.0, or 10.3 ng/mL in average after injection of 200,000 IU, 400,000 IU, or 600,000 IU D2. 25(oh)d 20-27 WASP family member 2 Homo sapiens 52-57 32924829-6 2020 RESULTS: There were significant differences in mean 25(OH)D concentration between patients group (19.37 +- 9.72 ng/ml) and controls 35.90 +- 9.66 ng/ml(p < 0.05), with significant difference between active and inactive patients (p < 0.05).There were significant negative correlations between serum 25(OH)D and SLEDAI (r-0.545, p 0.001), steroid dose (r-0.561, p 0.001), anti-dsDNA (r-0.685, p 0.006), 24 hr-proteinuria (r-0.738, p 0.001) and PTH (r-0.335, p 0.001), significant positive correlations between 25(OH)D and C3 (r0.617, p 0.001),C4 (r0.544, p 0.001) serum Ca (r0.424, p 0.001) and Z score (r0.561, p 0.001),with non-significant correlations between 25(OH)D and serum P and both disease & steroid duration, (p > 0.05). 25(oh)d 52-59 parathyroid hormone Homo sapiens 442-445 33127933-9 2020 Subjects with serum 25(OH)D level <= 20 ng/mL were younger, more likely to be female and smoker, and had a higher incidence of hypertension, dyslipidemia, and metabolic syndrome, compared to those with serum 25(OH)D level > 20 ng/mL. 25(oh)d 20-27 thrombopoietin Mus musculus 230-232 33127933-10 2020 Additionally, patients with serum 25(OH)D level <= 20 ng/mL were associated with a lower risk of subclinical atherosclerosis (crude OR: 0.63, 95% CI 0.50-0.81, p < 0.001), according to univariate analysis. 25(oh)d 34-41 thrombopoietin Mus musculus 57-59 33114526-5 2020 This intracellular DBP provides an array of specific binding sites for 25-hydroxyvitamin D (25(OH)D), which diffuses into the cell from the extracellular fluid. 25(oh)d 92-99 D-box binding PAR bZIP transcription factor Homo sapiens 19-22 33114526-6 2020 When intracellular DBP undergoes proteolytic breakdown, the bound 25(OH)D is then released and diffuses back into the blood. 25(oh)d 66-73 D-box binding PAR bZIP transcription factor Homo sapiens 19-22 33114526-9 2020 Parathyroid hormone is the most likely factor enhancing the repeated cycling of 25(OH)D between skeletal muscle and blood. 25(oh)d 80-87 parathyroid hormone Homo sapiens 0-19 33134104-10 2020 The 25(OH)D level in KL grade I, II, III and IV was 43.40, 30.59, 31.56 and 33.93 ng/mL respectively (no difference, P = 0.47). 25(oh)d 4-11 klotho Homo sapiens 21-23 32638247-2 2020 Moreover, the 25(OH)D threshold for maximal suppression of parathyroid hormone (PTH) was evaluated to offer a reference value for preoperative nutritional care. 25(oh)d 14-21 parathyroid hormone Homo sapiens 59-78 32638247-2 2020 Moreover, the 25(OH)D threshold for maximal suppression of parathyroid hormone (PTH) was evaluated to offer a reference value for preoperative nutritional care. 25(oh)d 14-21 parathyroid hormone Homo sapiens 80-83 32638247-9 2020 When participants were stratified according to 25(OH)D concentrations (< 10, 10-15, 15-20, and >= 20 ng/mL), PTH increased at 25(OH)D < 10 ng/mL (beta = 48.34, p = 0.001) after adjusting for age, gender, and BMI. 25(oh)d 47-54 parathyroid hormone Homo sapiens 109-112 32638247-9 2020 When participants were stratified according to 25(OH)D concentrations (< 10, 10-15, 15-20, and >= 20 ng/mL), PTH increased at 25(OH)D < 10 ng/mL (beta = 48.34, p = 0.001) after adjusting for age, gender, and BMI. 25(oh)d 126-133 parathyroid hormone Homo sapiens 109-112 33061530-10 2020 Regression analysis demonstrated a significant inverse relationship between serum 25(OH)D levels and LDL-c (beta=-1.5; P=<0.001), and TC levels (beta=-1.4;P=0.003), and the association remained unchanged with further adjustment for age, sex, HTN, DM, serum albumin and eGFR. 25(oh)d 82-89 albumin Homo sapiens 251-264 33061530-10 2020 Regression analysis demonstrated a significant inverse relationship between serum 25(OH)D levels and LDL-c (beta=-1.5; P=<0.001), and TC levels (beta=-1.4;P=0.003), and the association remained unchanged with further adjustment for age, sex, HTN, DM, serum albumin and eGFR. 25(oh)d 82-89 epidermal growth factor receptor Homo sapiens 269-273 32306297-7 2020 PTH and SHPT development are related with S-25(OH)D, and PTH differed between all subgroups of S-25(OH)D. 25(oh)d 44-51 parathyroid hormone Homo sapiens 0-3 32673820-11 2020 CONCLUSION: This study shows that serum 25(OH)D deficiency is associated with decreased hBD-2 and LL-37 expression of GCF and gingival tissues in both gingivitis and CP patients. 25(oh)d 40-47 defensin beta 4A Homo sapiens 88-93 32673820-11 2020 CONCLUSION: This study shows that serum 25(OH)D deficiency is associated with decreased hBD-2 and LL-37 expression of GCF and gingival tissues in both gingivitis and CP patients. 25(oh)d 40-47 cathelicidin antimicrobial peptide Homo sapiens 98-103 32673820-11 2020 CONCLUSION: This study shows that serum 25(OH)D deficiency is associated with decreased hBD-2 and LL-37 expression of GCF and gingival tissues in both gingivitis and CP patients. 25(oh)d 40-47 guanylate cyclase 2F, retinal Homo sapiens 118-121 32306297-7 2020 PTH and SHPT development are related with S-25(OH)D, and PTH differed between all subgroups of S-25(OH)D. 25(oh)d 97-104 parathyroid hormone Homo sapiens 57-60 32306297-12 2020 CONCLUSIONS: A significant relationship existed between S-25(OH)D and development of PTH and SHPT. 25(oh)d 58-65 parathyroid hormone Homo sapiens 85-88 32335958-1 2020 25(OH)D (Vit D) promotes differentiation of epithelial cells also prevent inappropriate apoptosis, and upregulation of inflammatory cytokines in keratinocytes. 25(oh)d 0-7 vitrin Homo sapiens 9-12 32871878-4 2020 Serum 25(OH)D levels were negatively correlated with hs-CRP, while not with TNF-alpha. 25(oh)d 6-13 C-reactive protein Homo sapiens 56-59 32726751-10 2020 Notably, this relationship emerged among individuals with a 25(OH)D concentration (~22 ng mL-1) approaching the deficiency cutoff. 25(oh)d 60-67 L1 cell adhesion molecule Mus musculus 90-94 32884429-3 2020 This study explored the associations between circulating 25-hydroxyvitamin D (25(OH)D) and fat deposition in muscle tissues of adult Arab males. 25(oh)d 78-85 FAT atypical cadherin 1 Homo sapiens 91-94 32884429-11 2020 In conclusion, low circulating 25(OH)D is associated with enhanced fat infiltration in muscle tissues of adult Arab males. 25(oh)d 31-38 FAT atypical cadherin 1 Homo sapiens 67-70 32821633-3 2020 Evidence suggests that low serum 25-hydroxycholicalciferol [25(OH)D] levels are associated with an increase in parathyroid hormone (PTH). 25(oh)d 60-67 parathyroid hormone Homo sapiens 111-130 32821633-3 2020 Evidence suggests that low serum 25-hydroxycholicalciferol [25(OH)D] levels are associated with an increase in parathyroid hormone (PTH). 25(oh)d 60-67 parathyroid hormone Homo sapiens 132-135 32790765-13 2020 In mothers, serum 25(OH)D was positively associated with CD4% (r = 0.40, p = 0.016). 25(oh)d 18-25 CD4 molecule Homo sapiens 57-60 32502237-10 2020 In the group with a higher albumin level (>=40 g/L), participants with a lower level of 25(OH)D (<50 nmol/L) had higher risk of mortality than their counterparts (Hazard ratio: 1.92, 95% Confidence Interval =1.45-2.56), and the association was more pronounced in women. 25(oh)d 88-95 albumin Homo sapiens 27-34 32502237-13 2020 The association between 25(OH)D and mortality was more pronounced in participants with higher albumin levels. 25(oh)d 24-31 albumin Homo sapiens 94-101 32360157-8 2020 Moreover, the serum concentration of 25(OH)D had a significant negative correlation with serum IL-21 concentration in the HT and GD children before or after treatment. 25(oh)d 37-44 interleukin 21 Homo sapiens 95-100 32360157-9 2020 Therefore, we studied the correlation between IL-21 and 25(OH)D, and infer that they play a role in AITD. 25(oh)d 56-63 interleukin 21 Homo sapiens 46-51 32583974-5 2020 Using a polyclonal antibody, two different chemical inhibitors, and high-density lipoprotein as a competing ligand, we demonstrate that the 25(OH)D signaling pathway in myeloid cells depends on scavenger receptor class B type I (SR-B1). 25(oh)d 140-147 scavenger receptor class B member 1 Homo sapiens 229-234 32583974-7 2020 SR-B1 blockade abrogates the cellular uptake of 25(OH)D leading to a general shut down of the gene transcription program modulated by 25(OH)D. 25(oh)d 48-55 scavenger receptor class B member 1 Homo sapiens 0-5 32583974-7 2020 SR-B1 blockade abrogates the cellular uptake of 25(OH)D leading to a general shut down of the gene transcription program modulated by 25(OH)D. 25(oh)d 134-141 scavenger receptor class B member 1 Homo sapiens 0-5 32684941-7 2020 Increased serum 25(OH)D was significantly associated with decreasing TC, TG, HDL-C, LDL-C, and hs-CRP levels. 25(oh)d 16-23 C-reactive protein Homo sapiens 98-101 32681041-5 2020 Serum levels of 25(OH)D at 28 and 36 weeks of age were increased in Vit.D-UV+ group as compared with Vit.D-UV- group. 25(oh)d 16-23 vitrin Mus musculus 68-71 32684941-9 2020 Mediators that had appreciable shares of the associations between 25(OH)D and hs-CRP was TG (10.2% of the association; beta = - 0.011; total indirect effect: 95% CI: - 0.019, - 0.002). 25(oh)d 66-73 C-reactive protein Homo sapiens 81-84 32684941-10 2020 The cubic model suggested that a steep increase in the adjusted regression coefficient of lipid with hs-CRP up to 50 nmol/L of 25(OH)D, and the highest adjusted regression coefficients were observed in pregnant women with 25(OH)D above 50 nmol/L. 25(oh)d 127-134 C-reactive protein Homo sapiens 104-107 32684941-10 2020 The cubic model suggested that a steep increase in the adjusted regression coefficient of lipid with hs-CRP up to 50 nmol/L of 25(OH)D, and the highest adjusted regression coefficients were observed in pregnant women with 25(OH)D above 50 nmol/L. 25(oh)d 222-229 C-reactive protein Homo sapiens 104-107 32325367-2 2020 Our aim was therefore to assess the association of serum 25-hydroxyvitamin D (25(OH)D) with C-reactive protein (CRP), leptin and adiponectin and the role of adiposity in this relationship. 25(oh)d 78-85 C-reactive protein Homo sapiens 92-110 32325367-2 2020 Our aim was therefore to assess the association of serum 25-hydroxyvitamin D (25(OH)D) with C-reactive protein (CRP), leptin and adiponectin and the role of adiposity in this relationship. 25(oh)d 78-85 C-reactive protein Homo sapiens 112-115 32325367-2 2020 Our aim was therefore to assess the association of serum 25-hydroxyvitamin D (25(OH)D) with C-reactive protein (CRP), leptin and adiponectin and the role of adiposity in this relationship. 25(oh)d 78-85 leptin Homo sapiens 118-124 32325367-2 2020 Our aim was therefore to assess the association of serum 25-hydroxyvitamin D (25(OH)D) with C-reactive protein (CRP), leptin and adiponectin and the role of adiposity in this relationship. 25(oh)d 78-85 adiponectin, C1Q and collagen domain containing Homo sapiens 129-140 32325367-8 2020 Although after adjustment for most examined potential confounders, each 10 nmol/L increase in serum 25(OH)D was associated with 2.3% (95%CI: -4.0 to -0.5) lower CRP, 3.5% (-4.7 to -2.2) lower leptin, and 0.13 ng/mL (0.04-0.21) higher adiponectin, most of these associations seemed to largely stem from an additional potential confounder - adiposity - as they either disappeared (leptin and CRP) or were largely diminished (adiponectin) upon further adjustment for adiposity indices (total body fat and waist circumference). 25(oh)d 100-107 C-reactive protein Homo sapiens 161-164 32325367-8 2020 Although after adjustment for most examined potential confounders, each 10 nmol/L increase in serum 25(OH)D was associated with 2.3% (95%CI: -4.0 to -0.5) lower CRP, 3.5% (-4.7 to -2.2) lower leptin, and 0.13 ng/mL (0.04-0.21) higher adiponectin, most of these associations seemed to largely stem from an additional potential confounder - adiposity - as they either disappeared (leptin and CRP) or were largely diminished (adiponectin) upon further adjustment for adiposity indices (total body fat and waist circumference). 25(oh)d 100-107 leptin Homo sapiens 192-198 32325367-8 2020 Although after adjustment for most examined potential confounders, each 10 nmol/L increase in serum 25(OH)D was associated with 2.3% (95%CI: -4.0 to -0.5) lower CRP, 3.5% (-4.7 to -2.2) lower leptin, and 0.13 ng/mL (0.04-0.21) higher adiponectin, most of these associations seemed to largely stem from an additional potential confounder - adiposity - as they either disappeared (leptin and CRP) or were largely diminished (adiponectin) upon further adjustment for adiposity indices (total body fat and waist circumference). 25(oh)d 100-107 adiponectin, C1Q and collagen domain containing Homo sapiens 234-245 32325367-8 2020 Although after adjustment for most examined potential confounders, each 10 nmol/L increase in serum 25(OH)D was associated with 2.3% (95%CI: -4.0 to -0.5) lower CRP, 3.5% (-4.7 to -2.2) lower leptin, and 0.13 ng/mL (0.04-0.21) higher adiponectin, most of these associations seemed to largely stem from an additional potential confounder - adiposity - as they either disappeared (leptin and CRP) or were largely diminished (adiponectin) upon further adjustment for adiposity indices (total body fat and waist circumference). 25(oh)d 100-107 leptin Homo sapiens 379-385 32325367-8 2020 Although after adjustment for most examined potential confounders, each 10 nmol/L increase in serum 25(OH)D was associated with 2.3% (95%CI: -4.0 to -0.5) lower CRP, 3.5% (-4.7 to -2.2) lower leptin, and 0.13 ng/mL (0.04-0.21) higher adiponectin, most of these associations seemed to largely stem from an additional potential confounder - adiposity - as they either disappeared (leptin and CRP) or were largely diminished (adiponectin) upon further adjustment for adiposity indices (total body fat and waist circumference). 25(oh)d 100-107 C-reactive protein Homo sapiens 390-393 32325367-8 2020 Although after adjustment for most examined potential confounders, each 10 nmol/L increase in serum 25(OH)D was associated with 2.3% (95%CI: -4.0 to -0.5) lower CRP, 3.5% (-4.7 to -2.2) lower leptin, and 0.13 ng/mL (0.04-0.21) higher adiponectin, most of these associations seemed to largely stem from an additional potential confounder - adiposity - as they either disappeared (leptin and CRP) or were largely diminished (adiponectin) upon further adjustment for adiposity indices (total body fat and waist circumference). 25(oh)d 100-107 adiponectin, C1Q and collagen domain containing Homo sapiens 423-434 32325367-9 2020 CONCLUSION: We found that measures of adiposity largely explained the negative association of serum 25(OH)D with the pro-inflammatory CRP and leptin, and the positive association with the anti-inflammatory adiponectin. 25(oh)d 100-107 C-reactive protein Homo sapiens 134-137 32325367-9 2020 CONCLUSION: We found that measures of adiposity largely explained the negative association of serum 25(OH)D with the pro-inflammatory CRP and leptin, and the positive association with the anti-inflammatory adiponectin. 25(oh)d 100-107 leptin Homo sapiens 142-148 32464532-10 2020 Minor allele of GC-rs4588-A was associated with lower serum 25(OH)D in the meta-analysis of both CWE (beta -8.11, P = 0.002) and Malaysian healthy children (beta -5.08, P < 0.001), while VDR-rs7975232-A was significantly associated with reduced odds of vitamin D deficiency in Malay subgroup of CWE (OR: 0.16; 95% CI: 0.06-0.49; P = 0.001) and this association was not found in the healthy children group. 25(oh)d 60-67 vitamin D receptor Homo sapiens 187-190 32741494-9 2020 There was a moderate inverse association between serum 25(OH)D concentration and LPS-stimulated TNF-alpha production in shelter dogs (r2 = 0.40, P = 0.04). 25(oh)d 55-62 tumor necrosis factor Canis lupus familiaris 96-105 32415728-10 2020 On the other hand, PTH levels showed an opposite response to seasonal effects relative to 25(OH)D. 25(oh)d 90-97 parathyroid hormone Homo sapiens 19-22 32415728-11 2020 Age, BMI and daylight were not significantly correlated with 25(OH)D and serum PTH reached a plateau at higher values of serum 25(OH)D of 42.86 nmol/L. 25(oh)d 127-134 parathyroid hormone Homo sapiens 79-82 32655486-2 2020 We explored age- and sex-related effects on 25-hydroxyvitamin D (25(OH)D) and correlation between 25(OH)D levels and BPPV. 25(oh)d 98-105 benign paroxysmal positional vertigo Homo sapiens 117-121 32884689-12 2020 Variants of GC (rs1155563) and CYP24A1 (rs6013897) were significantly associated with both 25(OH)D concentrations and vitamin D deficiency among pregnant women, respectively. 25(oh)d 91-98 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 31-38 32884689-14 2020 Genetic mutants in the vitamin D pathway (GC and CYP24A1) were significantly associated with 25(OH)D levels in pregnant women in Eastern and Central China. 25(oh)d 93-100 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 49-56 32655486-6 2020 Results: 25(OH)D levels in male subgroups were significant higher than those in female subgroup both in the BPPV and control group. 25(oh)d 9-16 benign paroxysmal positional vertigo Homo sapiens 108-112 32393583-4 2020 Vitamin D deficiency is prevalent among RTT patients, and we find that Mecp2-null mice similarly have significantly reduced 25(OH)D serum levels compared to wildtype littermates. 25(oh)d 124-131 methyl-CpG binding protein 2 Homo sapiens 71-76 32565795-10 2020 In a subgroup analysis, serum 25(OH)D levels inversely correlated with lipoprotein(a) levels in men (beta = -0.185, P = 0.002) and RBG levels in women (beta = -0.176, P = 0.028). 25(oh)d 30-37 lipoprotein(a) Homo sapiens 71-85 32449055-7 2020 Besides, serum adiponectin levels were positively associated with 25(OH)D levels, and negatively correlated with C-reactive protein and IL-6 levels in knee OA. 25(oh)d 66-73 adiponectin, C1Q and collagen domain containing Homo sapiens 15-26 32551035-3 2020 Low circulating 25-hydroxyvitamin D (25(OH)D) levels related to menopause are linked to diet, lifestyle, changes in body composition, insulin sensitivity, and reduced physical activity. 25(oh)d 37-44 insulin Homo sapiens 134-141 32441564-7 2022 PTH levels inversely mirrored 25(OH)D concentrations for all age and gender subgroups, and 25(OH)D deficient subgroups presented higher PTH levels than their non-deficient counterparts. 25(oh)d 30-37 parathyroid hormone Homo sapiens 0-3 32441564-7 2022 PTH levels inversely mirrored 25(OH)D concentrations for all age and gender subgroups, and 25(OH)D deficient subgroups presented higher PTH levels than their non-deficient counterparts. 25(oh)d 91-98 parathyroid hormone Homo sapiens 136-139 32441564-8 2022 In the non-deficient 25(OH)D population, PTH levels were the highest at 11 years old for girls and 14 years old for boys. 25(oh)d 21-28 parathyroid hormone Homo sapiens 41-44 32441564-10 2022 CONCLUSION: Our results highlight the inverse relationship between PTH and 25(OH)D in children and the need for a well characterized 25(OH)D population to establish pediatric reference ranges for PTH. 25(oh)d 75-82 parathyroid hormone Homo sapiens 67-70 32494176-6 2020 Multivariate logistic regression analysis was used to assess the association between serum level of 25(OH)D and lipid profile in insulin-sensitive versus -resistant individuals. 25(oh)d 100-107 insulin Homo sapiens 129-136 32477429-2 2020 The purpose of our study was to investigate the association of circulating Nrg4 with DPN and 25-hydroxy vitamin D [25(OH)D], a multifunctional secosteroid hormone that regulates other neurotrophic factors and adipokines gene expression, and other diabetic vascular complications. 25(oh)d 115-122 neuregulin 4 Homo sapiens 75-79 32477429-5 2020 Results: Circulating Nrg4 levels were significantly lower in nT2DM patients with DPN than those without, and subjects in the highest quartile of circulating Nrg4 had significantly lower vibration perception threshold (VPT), the prevalence of DPN, the proportion of persons with VPT > 25 V, and significantly higher circulating 25(OH)D (all P < 0.01). 25(oh)d 327-334 neuregulin 4 Homo sapiens 157-161 32477429-6 2020 Moreover, circulating Nrg4 was positively and independently associated with 25(OH)D, and was negatively with VPT (P < 0.01 or P < 0.05), but showed no associations with the prevalence of peripheral arterial disease, diabetic nephropathy, and diabetic retinopathy (all P > 0.05). 25(oh)d 76-83 neuregulin 4 Homo sapiens 22-26 32477429-8 2020 Conclusions: These data demonstrate that decreased levels of circulating Nrg4 might lead to the development of DPN through its close interaction with circulating 25(OH)D not with other diabetic vascular complications. 25(oh)d 162-169 neuregulin 4 Homo sapiens 73-77 32494176-11 2020 Furthermore, deficient 25(OH)D individuals with low HDL-C levels had higher circulatory IL-6 and IL-8 levels, and higher serum soluble TM compared to individuals with sufficient 25(OH)D and normal lipid profiles (median, IL-6 pg/mL 0.82 vs 1.71, P=0.001; median, IL-8 pg/mL 51.31 vs 145.6, P=0.003; and median, soluble TM ng/mL 5.19 vs 7.38, P<0.0001; in sufficient vs deficient groups, respectively). 25(oh)d 23-30 interleukin 6 Homo sapiens 88-92 32494176-11 2020 Furthermore, deficient 25(OH)D individuals with low HDL-C levels had higher circulatory IL-6 and IL-8 levels, and higher serum soluble TM compared to individuals with sufficient 25(OH)D and normal lipid profiles (median, IL-6 pg/mL 0.82 vs 1.71, P=0.001; median, IL-8 pg/mL 51.31 vs 145.6, P=0.003; and median, soluble TM ng/mL 5.19 vs 7.38, P<0.0001; in sufficient vs deficient groups, respectively). 25(oh)d 23-30 C-X-C motif chemokine ligand 8 Homo sapiens 97-101 32494176-11 2020 Furthermore, deficient 25(OH)D individuals with low HDL-C levels had higher circulatory IL-6 and IL-8 levels, and higher serum soluble TM compared to individuals with sufficient 25(OH)D and normal lipid profiles (median, IL-6 pg/mL 0.82 vs 1.71, P=0.001; median, IL-8 pg/mL 51.31 vs 145.6, P=0.003; and median, soluble TM ng/mL 5.19 vs 7.38, P<0.0001; in sufficient vs deficient groups, respectively). 25(oh)d 23-30 interleukin 6 Homo sapiens 221-225 32494176-11 2020 Furthermore, deficient 25(OH)D individuals with low HDL-C levels had higher circulatory IL-6 and IL-8 levels, and higher serum soluble TM compared to individuals with sufficient 25(OH)D and normal lipid profiles (median, IL-6 pg/mL 0.82 vs 1.71, P=0.001; median, IL-8 pg/mL 51.31 vs 145.6, P=0.003; and median, soluble TM ng/mL 5.19 vs 7.38, P<0.0001; in sufficient vs deficient groups, respectively). 25(oh)d 23-30 C-X-C motif chemokine ligand 8 Homo sapiens 263-267 33467248-5 2020 Linear regression examined relationships between 25(OH)D; VDBP; bioavailable 25(OH)D; and whole body, hip, and spine BMD. 25(oh)d 49-56 hedgehog interacting protein Homo sapiens 36-39 32300060-9 2020 Associations with NfL concentrations at year 11 corroborated these findings-a 50-nmol/L higher mean 25(OH)D in the first 2 years was associated with 20% lower NfL (95% CI: -36% to 0%), whereas smokers had 20% higher NfL levels than nonsmokers (95% CI: 2%-40%). 25(oh)d 100-107 neurofilament light chain Homo sapiens 18-21 32300060-9 2020 Associations with NfL concentrations at year 11 corroborated these findings-a 50-nmol/L higher mean 25(OH)D in the first 2 years was associated with 20% lower NfL (95% CI: -36% to 0%), whereas smokers had 20% higher NfL levels than nonsmokers (95% CI: 2%-40%). 25(oh)d 100-107 neurofilament light chain Homo sapiens 159-162 32300060-9 2020 Associations with NfL concentrations at year 11 corroborated these findings-a 50-nmol/L higher mean 25(OH)D in the first 2 years was associated with 20% lower NfL (95% CI: -36% to 0%), whereas smokers had 20% higher NfL levels than nonsmokers (95% CI: 2%-40%). 25(oh)d 100-107 neurofilament light chain Homo sapiens 159-162 32374278-9 2020 However, 25(OH)D levels were significantly higher at both 6 (63.5 vs. 30.3 nmol/L, p < 0.001) and 12 months (69.4 vs. 30 nmol/L, p < 0.001) in treated vs. untreated patients, corresponding with a significant reduction in PTH at both 6 (112 vs. 161 pg/mL) and 12 months (109 vs. 154 pg/mL) in treated vs. untreated patients, respectively (p < 0.001 for both). 25(oh)d 9-16 parathyroid hormone Homo sapiens 221-224 32232398-11 2020 25(OH)D was inversely associated with sICAM-1, hs-CRP, and AGP, which were positively associated with BMI. 25(oh)d 0-7 C-reactive protein Homo sapiens 50-53 32367244-4 2020 PURPOSE: Seasonal variation of parathyroid hormone (PTH) and its dependency on serum 25-hydroxy vitamin D (25(OH)D) levels are well-described. 25(oh)d 107-114 parathyroid hormone Homo sapiens 31-50 32367244-4 2020 PURPOSE: Seasonal variation of parathyroid hormone (PTH) and its dependency on serum 25-hydroxy vitamin D (25(OH)D) levels are well-described. 25(oh)d 107-114 parathyroid hormone Homo sapiens 52-55 32367244-6 2020 We describe the seasonal variation of serum PTH and its relation with serum 25(OH)D levels in Romania. 25(oh)d 76-83 parathyroid hormone Homo sapiens 44-47 32367244-14 2020 PTH correlated inversely with serum 25(OH)D with a breakpoint of 12.82 ng/mL in 2800 subjects who had a simultaneous measurement of 25(OH)D. 25(oh)d 36-43 parathyroid hormone Homo sapiens 0-3 32367244-14 2020 PTH correlated inversely with serum 25(OH)D with a breakpoint of 12.82 ng/mL in 2800 subjects who had a simultaneous measurement of 25(OH)D. 25(oh)d 132-139 parathyroid hormone Homo sapiens 0-3 32367244-16 2020 CONCLUSIONS: We showed a mild seasonal variation of serum PTH in Romania, at an inverse sinusoidal pattern than serum 25(OH)D. 25(oh)d 118-125 parathyroid hormone Homo sapiens 58-61 32007562-17 2020 Regression analyses did not show significant differences between cases and controls in relationships between vitamin D metabolites and with PTH, except for the free 25(OH)D-PTH relationship and a higher free:total 25(OH)D ratio in cases at T1. 25(oh)d 165-172 parathyroid hormone Homo sapiens 173-176 32412426-3 2020 With decreasing serum 25(OH)D levels there is an increase in serum PTH. 25(oh)d 22-29 parathyroid hormone Homo sapiens 67-70 32412426-8 2020 Serum parathyroid hormone (PTH) and change in PTH after vitamin D supplementation were related to serum 25(OH)D levels in steps of 25 nmol/L (<24, 25-49, 50-74, 75-99, and >99 nmol/L). 25(oh)d 104-111 parathyroid hormone Homo sapiens 6-25 32412426-8 2020 Serum parathyroid hormone (PTH) and change in PTH after vitamin D supplementation were related to serum 25(OH)D levels in steps of 25 nmol/L (<24, 25-49, 50-74, 75-99, and >99 nmol/L). 25(oh)d 104-111 parathyroid hormone Homo sapiens 27-30 32412426-8 2020 Serum parathyroid hormone (PTH) and change in PTH after vitamin D supplementation were related to serum 25(OH)D levels in steps of 25 nmol/L (<24, 25-49, 50-74, 75-99, and >99 nmol/L). 25(oh)d 104-111 parathyroid hormone Homo sapiens 46-49 32412426-9 2020 Results: In the Tromso study, in the females there was a gradual decrease in serum PTH with increasing serum 25(OH)D with no apparent plateau, whereas in the males the decrease in PTH in subjects with serum 25(OH)D >74 nmol/l was marginal. 25(oh)d 109-116 parathyroid hormone Homo sapiens 83-86 32412426-9 2020 Results: In the Tromso study, in the females there was a gradual decrease in serum PTH with increasing serum 25(OH)D with no apparent plateau, whereas in the males the decrease in PTH in subjects with serum 25(OH)D >74 nmol/l was marginal. 25(oh)d 207-214 parathyroid hormone Homo sapiens 180-183 32412426-11 2020 Conclusions: The use of the serum PTH-25(OH)D relation from observational studies to determine a threshold for vitamin D sufficiency is highly questionable. 25(oh)d 38-45 parathyroid hormone Homo sapiens 34-37 31709849-7 2020 Patients with abdominal obesity (waist circumference >80 cm) independently of PCOS status had significantly higher levels of FGF23 (112.5 +- 86.5 vs. 73.4 +- 37.9 pg/ml; p = .023) and lower of 25(OH)D (35.8 +- 21.4 vs 47.8 +- 26.5 nmol/l; p = .034). 25(oh)d 193-200 fibroblast growth factor 23 Homo sapiens 125-130 31957666-7 2020 There was an inverse correlation between serum 25(OH)D and visfatin in the subgroup with vitamin D insufficiency. 25(oh)d 47-54 nicotinamide phosphoribosyltransferase Homo sapiens 59-67 31957666-8 2020 CONCLUSION: Vitamin D might be beneficial in decreasing proangiogenic factors such as visfatin in UC patients with low 25(OH)D levels. 25(oh)d 119-126 nicotinamide phosphoribosyltransferase Homo sapiens 86-94 32425877-3 2020 Objectives: To examine the association between physiological variations in serum 25(OH)D and NfL levels in RRMS patients before and during disease modifying therapy (DMT). 25(oh)d 81-88 neurofilament light chain Homo sapiens 93-96 30628561-10 2020 Plasma 25(OH)D correlated positively with serum P (r = 0 24, P <0 001) and Ca intake (r = 0 16, P 0 03), negatively with age (r = -0 13, P 0 03) and PTH (r = -0 22, P <0 001.). 25(oh)d 7-14 parathyroid hormone Homo sapiens 149-152 31120008-9 2020 When the children and adolescents were stratified by gender, we found stronger associations between serum 25(OH)D concentration and both HDL-cholesterol and insulin resistance in girls. 25(oh)d 106-113 insulin Homo sapiens 157-164 32440968-0 2020 1,25(OH)D vitamin D promotes NOS2 expression in response to bacterial and viral PAMPs in primary bovine salivary gland fibroblasts. 25(oh)d 2-9 nitric oxide synthase 2 Bos taurus 29-33 32440968-6 2020 In contrast, 1,25(OH)D significantly up-regulates the expression of the NOS2 gene encoding iNOS in bovine submandibular stromal cells compared to EtOH (vehicle) control and this is a maintained response to all three bacterial and viral ligands. 25(oh)d 15-22 nitric oxide synthase 2 Bos taurus 72-76 32440968-6 2020 In contrast, 1,25(OH)D significantly up-regulates the expression of the NOS2 gene encoding iNOS in bovine submandibular stromal cells compared to EtOH (vehicle) control and this is a maintained response to all three bacterial and viral ligands. 25(oh)d 15-22 nitric oxide synthase 2 Bos taurus 91-95 32425877-7 2020 Associations between 25(OH)D and NfL levels were analyzed with linear regression models for the whole study period and the periods before and during IFN-beta treatment. 25(oh)d 21-28 neurofilament light chain Homo sapiens 33-36 32296394-9 2020 Serum 25(OH)D concentration was significantly negatively correlated with body mass index (BMI), waist-to-hip ratio (WHR), fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-sensitivity C-reactive protein (hs-CRP) (P < 0.05). 25(oh)d 6-13 insulin Homo sapiens 130-137 32272973-12 2020 A negative correlation was observed between post exercise 25(OH)D levels and myoglobin levels (r = - 0.57; p = 0.05), and 25(OH)D levels and TNFalpha (r = - 0.58; p = 0.05) in vitamin D supplemented group. 25(oh)d 58-65 myoglobin Homo sapiens 77-86 32272973-12 2020 A negative correlation was observed between post exercise 25(OH)D levels and myoglobin levels (r = - 0.57; p = 0.05), and 25(OH)D levels and TNFalpha (r = - 0.58; p = 0.05) in vitamin D supplemented group. 25(oh)d 122-129 tumor necrosis factor Homo sapiens 141-149 32357490-8 2020 DBP was positively associated with total 25(OH)D and expectedly, negatively associated with free 25(OH)D. 25(oh)d 41-48 D-box binding PAR bZIP transcription factor Homo sapiens 0-3 32357490-8 2020 DBP was positively associated with total 25(OH)D and expectedly, negatively associated with free 25(OH)D. 25(oh)d 97-104 D-box binding PAR bZIP transcription factor Homo sapiens 0-3 32296394-9 2020 Serum 25(OH)D concentration was significantly negatively correlated with body mass index (BMI), waist-to-hip ratio (WHR), fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-sensitivity C-reactive protein (hs-CRP) (P < 0.05). 25(oh)d 6-13 insulin Homo sapiens 171-178 32296394-9 2020 Serum 25(OH)D concentration was significantly negatively correlated with body mass index (BMI), waist-to-hip ratio (WHR), fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-sensitivity C-reactive protein (hs-CRP) (P < 0.05). 25(oh)d 6-13 C-reactive protein Homo sapiens 286-304 32071197-7 2020 RESULTS: Triglycerides, FBG, insulin, and homeostasis model assessment of insulin resistance were inversely associated with 25(OH)D concentrations (p<0.05) in both sexes. 25(oh)d 124-131 insulin Homo sapiens 29-36 31255367-8 2020 A significant negative correlation was noted between Lp-PLA2 and 25(OH)D in the vitamin D insufficiency group (r=-0.364, p=0.009). 25(oh)d 65-72 phospholipase A2 group VII Homo sapiens 53-60 31255367-10 2020 CONCLUSIONS: From this cohort of patients with type 2 diabetes, regardless of traditional cardiovascular risk factors, we observed a statistically significant inverse relation between Lp-PLA2 and 25(OH)D at levels <30ng/mL. 25(oh)d 196-203 phospholipase A2 group VII Homo sapiens 184-191 31665381-3 2020 OBJECTIVES: We investigated the acute intestinal response to orally consumed 25(OH)D in mice by assessing mRNA induction of cytochrome p450 family 24 subfamily A member 1 (Cyp24), a vitamin D-dependent gene. 25(oh)d 77-84 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 172-177 31665381-8 2020 RESULTS: Oral 25(OH)D induced expression of Cyp24 mRNA in the duodenum of mice with 80 ng 25(OH)D by 3.3 +- 0.8 DeltaDeltaCt compared with controls (P < 0.05). 25(oh)d 14-21 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 44-49 31665381-8 2020 RESULTS: Oral 25(OH)D induced expression of Cyp24 mRNA in the duodenum of mice with 80 ng 25(OH)D by 3.3 +- 0.8 DeltaDeltaCt compared with controls (P < 0.05). 25(oh)d 90-97 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 44-49 32178228-10 2020 The fact that serum 25(OH)D concentration was inversely associated with metabolic syndrome and insulin resistance not only reaffirms the relevance to consider serum 25(OH)D concentration as an influencing factor for insulin resistance, but also the need to actively screen for hypovitaminosis D in all patients with this condition. 25(oh)d 20-27 insulin Homo sapiens 95-102 32178228-10 2020 The fact that serum 25(OH)D concentration was inversely associated with metabolic syndrome and insulin resistance not only reaffirms the relevance to consider serum 25(OH)D concentration as an influencing factor for insulin resistance, but also the need to actively screen for hypovitaminosis D in all patients with this condition. 25(oh)d 20-27 insulin Homo sapiens 216-223 31665381-9 2020 In vitro, both Caco2 and HT-29 cells responded to 25(OH)D treatment with 200-fold and 175-fold greater effective concentration at 50% maximal response than 1,25(OH)2D, yet inhibition of 1alpha-OHase and knockdown of CYP27B1 had no effect on the responses. 25(oh)d 50-57 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 186-198 31665381-9 2020 In vitro, both Caco2 and HT-29 cells responded to 25(OH)D treatment with 200-fold and 175-fold greater effective concentration at 50% maximal response than 1,25(OH)2D, yet inhibition of 1alpha-OHase and knockdown of CYP27B1 had no effect on the responses. 25(oh)d 50-57 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 216-223 31665381-11 2020 In vitro assessments suggest that the response from 25(OH)D does not require activation by 1alpha-OHase and that 25(OH)D within the intestinal lumen acts as a vitamin D receptor agonist. 25(oh)d 113-120 vitamin D receptor Homo sapiens 159-177 32071197-7 2020 RESULTS: Triglycerides, FBG, insulin, and homeostasis model assessment of insulin resistance were inversely associated with 25(OH)D concentrations (p<0.05) in both sexes. 25(oh)d 124-131 insulin Homo sapiens 74-81 31696245-8 2020 Serum 1,25(OH)D was significantly higher in HSF and NSF than HS (22.5 +- 1.2; 22.2 +- 1.2 vs 17.4 +- 1.2 pg/ml, p = 0.007) but serum 25(OH)D, PTH, klotho and plasma FGF-23 did not differ between groups. 25(oh)d 8-15 parathyroid hormone Homo sapiens 142-145 31696245-8 2020 Serum 1,25(OH)D was significantly higher in HSF and NSF than HS (22.5 +- 1.2; 22.2 +- 1.2 vs 17.4 +- 1.2 pg/ml, p = 0.007) but serum 25(OH)D, PTH, klotho and plasma FGF-23 did not differ between groups. 25(oh)d 8-15 klotho Homo sapiens 147-153 31696245-12 2020 Higher 1,25(OH)D/CYP24A1 ratio suggested a lower degradation of 1,25(OH)D by CYP24A1 in HSF and NSF. 25(oh)d 9-16 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 77-84 31696245-12 2020 Higher 1,25(OH)D/CYP24A1 ratio suggested a lower degradation of 1,25(OH)D by CYP24A1 in HSF and NSF. 25(oh)d 66-73 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 17-24 31696245-8 2020 Serum 1,25(OH)D was significantly higher in HSF and NSF than HS (22.5 +- 1.2; 22.2 +- 1.2 vs 17.4 +- 1.2 pg/ml, p = 0.007) but serum 25(OH)D, PTH, klotho and plasma FGF-23 did not differ between groups. 25(oh)d 8-15 fibroblast growth factor 23 Homo sapiens 165-171 31696245-12 2020 Higher 1,25(OH)D/CYP24A1 ratio suggested a lower degradation of 1,25(OH)D by CYP24A1 in HSF and NSF. 25(oh)d 66-73 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 77-84 32918214-6 2020 It seems probable that other factors such as ethnicity, phenotype, 25(OH)D plasma levels, and UV radiation exposure play a role as confounding factors and introduce heterogeneity.To conclude, there is some indication that VDR polymorphisms may modulate the risk of some cancer sites and in future studies VDR genetic variation should be integrated also with assessment of vitamin D status and stratified by ethnicity. 25(oh)d 67-74 vitamin D receptor Homo sapiens 222-225 32990626-4 2020 However, studies and research of association between 25-Hydroxyvitamin D (25(OH)D) status and components of homeostasis model assessment of insulin resistance (HOMA-IR) in older are limited. 25(oh)d 74-81 insulin Homo sapiens 140-147 32844632-8 2020 In patients with MS and in the control, the GA genotype CYP24A1 (rs2248359) was associated with a 25(OH)D level of less than 30 ng/ml. 25(oh)d 98-105 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 56-63 32289634-6 2020 RESULTS: SNPs within GC, CYP2 R1, and CYP27 B1 were associated with 25(OH)D concentrations following supplementation. 25(oh)d 68-75 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 25-32 32289634-6 2020 RESULTS: SNPs within GC, CYP2 R1, and CYP27 B1 were associated with 25(OH)D concentrations following supplementation. 25(oh)d 68-75 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 38-46 32289634-9 2020 None of the SNPs were significantly associated with Gc-globulin concentrations; however, there was a significant interaction with one SNP in DHCR7 (rs12785878), which was associated with reduced free 25(OH)D concentrations in the supplemented arm. 25(oh)d 200-207 7-dehydrocholesterol reductase Homo sapiens 141-146 32121673-10 2019 Significantly higher serum 25(OH)D levels were observed with male gender (p=0.000), BMI for age <-2SD (p=0.000), daily milk consumption (p=0.000) and residing in dry zone (p=0.0 Conclusions: Though Sri Lanka is a tropical country, VDD is prevalent among school children aged 10-18 years. 25(oh)d 27-34 sorcin Homo sapiens 198-201 31384956-12 2019 Serum FGF23 was significantly and negatively correlated with phosphorus level after adjusted for age, gender, calcium, iPTH, and 25(OH)D in the euthyroid GD group. 25(oh)d 129-136 fibroblast growth factor 23 Homo sapiens 6-11 31841498-7 2019 For 25(OH)D, two strong GWA signals were identified, localizing to GC (Vitamin D binding protein) and CYP2R1 (Vitamin D 25-hydroxylase) genes. 25(oh)d 4-11 GC vitamin D binding protein Homo sapiens 71-96 31841498-7 2019 For 25(OH)D, two strong GWA signals were identified, localizing to GC (Vitamin D binding protein) and CYP2R1 (Vitamin D 25-hydroxylase) genes. 25(oh)d 4-11 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 102-108 31841498-7 2019 For 25(OH)D, two strong GWA signals were identified, localizing to GC (Vitamin D binding protein) and CYP2R1 (Vitamin D 25-hydroxylase) genes. 25(oh)d 4-11 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 110-134 31841498-11 2019 In this first GWA study on 25(OH)D in this age group we show that already at the age of 24 months genetic variation influences 25(OH)D concentrations and determines response to supplementation, with genome-wide significant associations with GC and CYP2R1. 25(oh)d 27-34 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 248-254 30885444-2 2019 The secondary objective was to investigate a correlation between 25(OH)D and CRP. 25(oh)d 65-72 C-reactive protein Homo sapiens 77-80 30885444-8 2019 25(OH)D varied with age, ethnic origin, BMI, season, CRP and medical history. 25(oh)d 0-7 C-reactive protein Homo sapiens 53-56 30885444-11 2019 25(OH)D was inversely correlated with CRP. 25(oh)d 0-7 C-reactive protein Homo sapiens 38-41 30885444-13 2019 25(OH)D was inversely correlated with CRP as observed in the general population. 25(oh)d 0-7 C-reactive protein Homo sapiens 38-41 31273631-6 2019 A significant inverse relationship was found between PTH and 25(OH)D (P < 0.001). 25(oh)d 61-68 parathyroid hormone Homo sapiens 53-56 31748273-9 2019 UV irradiation of DBP+/+ animals restored serum calcium and serum 25(OH)D while the same treatment of DBP-/- animals failed to show either a serum calcium or 25(OH)D response despite having normal vitamin D production in skin. 25(oh)d 66-73 D site albumin promoter binding protein Mus musculus 18-21 31752330-7 2019 Cluster analysis demonstrated that patients from cluster three, with the lowest 25(OH)D levels, presented the lowermost vitamin D intake, IL-10 (1.0 +- 0.9 pg/mL), and IL-12p70 (0.5 +- 0.4 pg/mL), but the highest TNF-alpha (9.1 +- 3.5 pg/mL), IL-8 (55.6 +- 117.1 pg/mL), IL-17A (3.5 +- 2.0 pg/mL), total-cholesterol (193.9 +- 61.4 mg/dL), LDL-cholesterol (127.7 +- 58.2 mg/dL), and Apo-B (101.4 +- 33.4 mg/dL) levels, compared with patients from cluster one. 25(oh)d 80-87 interleukin 10 Homo sapiens 138-143 31752330-7 2019 Cluster analysis demonstrated that patients from cluster three, with the lowest 25(OH)D levels, presented the lowermost vitamin D intake, IL-10 (1.0 +- 0.9 pg/mL), and IL-12p70 (0.5 +- 0.4 pg/mL), but the highest TNF-alpha (9.1 +- 3.5 pg/mL), IL-8 (55.6 +- 117.1 pg/mL), IL-17A (3.5 +- 2.0 pg/mL), total-cholesterol (193.9 +- 61.4 mg/dL), LDL-cholesterol (127.7 +- 58.2 mg/dL), and Apo-B (101.4 +- 33.4 mg/dL) levels, compared with patients from cluster one. 25(oh)d 80-87 tumor necrosis factor Homo sapiens 213-222 31752330-7 2019 Cluster analysis demonstrated that patients from cluster three, with the lowest 25(OH)D levels, presented the lowermost vitamin D intake, IL-10 (1.0 +- 0.9 pg/mL), and IL-12p70 (0.5 +- 0.4 pg/mL), but the highest TNF-alpha (9.1 +- 3.5 pg/mL), IL-8 (55.6 +- 117.1 pg/mL), IL-17A (3.5 +- 2.0 pg/mL), total-cholesterol (193.9 +- 61.4 mg/dL), LDL-cholesterol (127.7 +- 58.2 mg/dL), and Apo-B (101.4 +- 33.4 mg/dL) levels, compared with patients from cluster one. 25(oh)d 80-87 C-X-C motif chemokine ligand 8 Homo sapiens 243-247 31752330-7 2019 Cluster analysis demonstrated that patients from cluster three, with the lowest 25(OH)D levels, presented the lowermost vitamin D intake, IL-10 (1.0 +- 0.9 pg/mL), and IL-12p70 (0.5 +- 0.4 pg/mL), but the highest TNF-alpha (9.1 +- 3.5 pg/mL), IL-8 (55.6 +- 117.1 pg/mL), IL-17A (3.5 +- 2.0 pg/mL), total-cholesterol (193.9 +- 61.4 mg/dL), LDL-cholesterol (127.7 +- 58.2 mg/dL), and Apo-B (101.4 +- 33.4 mg/dL) levels, compared with patients from cluster one. 25(oh)d 80-87 interleukin 17A Homo sapiens 271-277 31752330-7 2019 Cluster analysis demonstrated that patients from cluster three, with the lowest 25(OH)D levels, presented the lowermost vitamin D intake, IL-10 (1.0 +- 0.9 pg/mL), and IL-12p70 (0.5 +- 0.4 pg/mL), but the highest TNF-alpha (9.1 +- 3.5 pg/mL), IL-8 (55.6 +- 117.1 pg/mL), IL-17A (3.5 +- 2.0 pg/mL), total-cholesterol (193.9 +- 61.4 mg/dL), LDL-cholesterol (127.7 +- 58.2 mg/dL), and Apo-B (101.4 +- 33.4 mg/dL) levels, compared with patients from cluster one. 25(oh)d 80-87 apolipoprotein B Homo sapiens 382-387 31484162-5 2019 Results: Serum 25(OH)D levels were associated with body mass index (BMI: r = -0.161, P = 0.006), PTH (r = -0.165; P = 0.005), CTX (r = -0.119; P = 0.043) and vBMD at cortical bone (Dcomp: r = 0.132; P = 0.033) and entire bone (D100: r = 0.162 P = 0.009) at the distal radius, but not at the tibia. 25(oh)d 15-22 parathyroid hormone Homo sapiens 97-100 31484162-5 2019 Results: Serum 25(OH)D levels were associated with body mass index (BMI: r = -0.161, P = 0.006), PTH (r = -0.165; P = 0.005), CTX (r = -0.119; P = 0.043) and vBMD at cortical bone (Dcomp: r = 0.132; P = 0.033) and entire bone (D100: r = 0.162 P = 0.009) at the distal radius, but not at the tibia. 25(oh)d 15-22 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 126-129 32337495-4 2020 Study-specific incidence rate ratios (RRs) for associations of prediagnostic, season-standardized 25(OH)D concentrations according to DBP2 isoform with CRC were estimated using multivariable unconditional logistic regression and were pooled using fixed-effects models. 25(oh)d 98-105 DEAH-box helicase 16 Homo sapiens 134-138 31650259-4 2019 We studied the relationship between maternal 25(OH)D level and newborn serum alkaline phosphatase activity (ALP) at term. 25(oh)d 45-52 alkaline phosphatase, placental Homo sapiens 108-111 31650259-11 2019 A significant inverse correlation (Pearson"s coefficient = - 0.18, p = 0.03) was observed between maternal 25(OH)D levels and babies" ALP activities. 25(oh)d 107-114 alkaline phosphatase, placental Homo sapiens 134-137 32337495-7 2020 The association of 25(OH)D concentrations with CRC risk differed by DBP2: 25(OH)D concentrations considered sufficient (>= 50 nmol/L), relative to deficient (< 30 nmol/L), were associated with a 53% lower CRC risk among individuals with the DBP2 isoform (RR = 0.47, 95% CI = 0.33 to 0.67), but with a non-statistically significant 12% lower risk among individuals without it (RR = 0.88, 95% CI = 0.61 to 1.27) (P heterogeneity = .01). 25(oh)d 74-81 DEAH-box helicase 16 Homo sapiens 68-72 32337495-6 2020 Results: The odds of having 25(OH)D concentrations less than 50 nmol/L (considered insufficient by the Institute of Medicine) were 43% higher for each DBP2-encoding variant (rs4588*A) inherited (per DBP2 odds ratio [OR] = 1.43, 95% confidence interval [CI] = 1.27 to 1.62, P trend = 1.2 x 10-8). 25(oh)d 28-35 DEAH-box helicase 16 Homo sapiens 151-155 32337495-7 2020 The association of 25(OH)D concentrations with CRC risk differed by DBP2: 25(OH)D concentrations considered sufficient (>= 50 nmol/L), relative to deficient (< 30 nmol/L), were associated with a 53% lower CRC risk among individuals with the DBP2 isoform (RR = 0.47, 95% CI = 0.33 to 0.67), but with a non-statistically significant 12% lower risk among individuals without it (RR = 0.88, 95% CI = 0.61 to 1.27) (P heterogeneity = .01). 25(oh)d 74-81 DEAH-box helicase 16 Homo sapiens 241-245 32337495-8 2020 Conclusions: Our results suggest that the 25(OH)D-CRC association may differ by DBP isoform, and those with a DBP2-encoding genotype linked to vitamin D insufficiency may particularly benefit from adequate 25(OH)D for CRC prevention. 25(oh)d 206-213 DEAH-box helicase 16 Homo sapiens 110-114 30088075-12 2019 In samples with a normal PTH, 25(OH)D was 11 nmol/L higher than in the entire cohort. 25(oh)d 30-37 parathyroid hormone Homo sapiens 25-28 31299118-9 2019 In patients with PE, 25(OH)D level correlated negatively with IL-6 levels (r = -.60, P < .0001) and positively with Treg/Th17 cell ratio (r = .89, P < .0001). 25(oh)d 21-28 interleukin 6 Homo sapiens 62-66 31427443-12 2019 Serum 25(OH)D concentration was inversely associated with TGF-beta levels in COPD patients. 25(oh)d 6-13 transforming growth factor alpha Homo sapiens 58-66 31583252-10 2019 Conclusion: The serum 25(OH)D level in patients with diabetes mellitus after long-term vitamin D3 supplementation is associated with CYP27B1 polymorphism. 25(oh)d 22-29 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 133-140 31358089-1 2019 OBJECTIVE: To identify DBP gene rs4588 and rs7041 polymorphisms and associate with participants" serum 25(OH)D and BMD levels. 25(oh)d 103-110 D-box binding PAR bZIP transcription factor Homo sapiens 23-26 29562766-4 2019 From the second month of life, there was a statistically significant relationship only between PTH and 25(OH)D (Rho = -0.71, p <= .0001). 25(oh)d 103-110 parathyroid hormone Homo sapiens 95-98 31496004-7 2019 RESULTS: Dogs with CIE and low serum 25(OH)D concentrations had higher canine chronic enteropathy clinical activity index scores (P = .003), lower serum alpha-tocopherol (P < .001), cholesterol (P < .001), and albumin (P < .001) concentrations and higher serum C-reactive protein (P = .004) concentrations compared to CIE dogs with normal serum 25(OH)D concentrations. 25(oh)d 37-44 albumin Canis lupus familiaris 210-217 31496004-7 2019 RESULTS: Dogs with CIE and low serum 25(OH)D concentrations had higher canine chronic enteropathy clinical activity index scores (P = .003), lower serum alpha-tocopherol (P < .001), cholesterol (P < .001), and albumin (P < .001) concentrations and higher serum C-reactive protein (P = .004) concentrations compared to CIE dogs with normal serum 25(OH)D concentrations. 25(oh)d 37-44 C-reactive protein Canis lupus familiaris 261-279 31129357-1 2019 BACKGROUND: While the inverse relationship between serum ionized calcium (Ca2+) and PTH is well-established, the relationship between 25(OH)D and PTH showed conflicting results. 25(oh)d 134-141 parathyroid hormone Homo sapiens 146-149 31129357-7 2019 For subjects <38 years, 25(OH)D was the most important parameter in regulating PTH. 25(oh)d 24-31 parathyroid hormone Homo sapiens 79-82 31129357-8 2019 For subjects >=38 both 25(OH)D and Ca2+ levels regulated PTH secretion. 25(oh)d 23-30 parathyroid hormone Homo sapiens 57-60 31129357-9 2019 Subjects with 25(OH)D < 13 ng/mL had average higher PTH; in this group only, subjects with Ca2+ >= 1.30 mmol/L had average lower PTH compared to subjects with Ca2+ < 1.30. 25(oh)d 14-21 parathyroid hormone Homo sapiens 52-55 31129357-11 2019 Anova Type III errors c indicated that 25(OH)D accounted for 32.1% of the total variance in PTH, Ca2+ accounted for 18% of the total variance, BMI for 14.3%, and 1,25(OH)2D for 11.1%. 25(oh)d 39-46 parathyroid hormone Homo sapiens 92-95 31385179-9 2019 Serum 25(OH)D levels showed significant but weak inverse correlations with CRP (r = - 0.205, p = 0.020) and with NLR (r = - 0.219, p = 0.013). 25(oh)d 6-13 C-reactive protein Homo sapiens 75-78 31129357-13 2019 This was confirmed by the regression tree approach, where 25(OH)D and Ca2+ accounted for the largest variation in the average levels of PTH. 25(oh)d 58-65 parathyroid hormone Homo sapiens 136-139 31129357-14 2019 DISCUSSION: Under stable conditions 25(OH)D plays a significant role in regulating PTH secretion. 25(oh)d 36-43 parathyroid hormone Homo sapiens 83-86 30993743-1 2019 BACKGROUND: The circulating concentration of 25(OH)D is widely applied to indicate the vitamin D status, as the directly metabolic genes of 25(OH)D, CYP2R1, and CYP27B1 are associated with the concentration of 25(OH)D. 25(oh)d 45-52 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 149-155 31362440-15 2019 The most sensitive and specific cut-off for 25(OH)D levels to predict the PhA above the median was >14 ng/mL (p < 0.001). 25(oh)d 44-51 lamin B receptor Homo sapiens 74-77 31533882-8 2019 CD8+ T-cell stimulation measured by QFT-Plus had borderline association with the serum level of 25(OH)D (P = 0.089).CONCLUSION: We showed a high rate of TB infection among HHCs in Mongolia. 25(oh)d 96-103 CD8a molecule Homo sapiens 0-3 30632419-1 2019 Low serum 25-hydroxyvitamin D [25(OH)D] concentrations are associated with a high risk of insulin resistance and Type 2 diabetes mellitus in adults. 25(oh)d 31-38 insulin Homo sapiens 90-97 30993743-1 2019 BACKGROUND: The circulating concentration of 25(OH)D is widely applied to indicate the vitamin D status, as the directly metabolic genes of 25(OH)D, CYP2R1, and CYP27B1 are associated with the concentration of 25(OH)D. 25(oh)d 45-52 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 161-168 30993743-1 2019 BACKGROUND: The circulating concentration of 25(OH)D is widely applied to indicate the vitamin D status, as the directly metabolic genes of 25(OH)D, CYP2R1, and CYP27B1 are associated with the concentration of 25(OH)D. 25(oh)d 140-147 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 161-168 30993743-1 2019 BACKGROUND: The circulating concentration of 25(OH)D is widely applied to indicate the vitamin D status, as the directly metabolic genes of 25(OH)D, CYP2R1, and CYP27B1 are associated with the concentration of 25(OH)D. 25(oh)d 140-147 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 161-168 31167402-8 2019 Overall, our findings suggest that changes in certain inflammatory biomarkers in breast cancer survivors with low plasma 25(OH)D levels, supplemented with vitamin D3, may depend on VDR SNPs and haplotypes. 25(oh)d 121-128 vitamin D receptor Homo sapiens 181-184 31061425-3 2019 We found a significant, inverse relationship between serum 25(OH)D and 1,25(OH)2D:24,25(OH)2D vitamin D metabolite ratio (VMR) (r2Exp = 0.582, p < 0.0001), and demonstrated a significant association with increasing PTH concentration (p < 0.001). 25(oh)d 59-66 parathyroid hormone Homo sapiens 215-218 30833174-1 2019 INTRODUCTION: This study aimed to explore the role of vitamin D receptor (VDR) in breast cancer tissues and its relation to serum 25-hydroxyvitamin D [25(OH)D] levels and estrogen receptor alpha (ER-alpha) gene expression in patients with breast cancer. 25(oh)d 151-158 vitamin D receptor Homo sapiens 54-72 30833174-1 2019 INTRODUCTION: This study aimed to explore the role of vitamin D receptor (VDR) in breast cancer tissues and its relation to serum 25-hydroxyvitamin D [25(OH)D] levels and estrogen receptor alpha (ER-alpha) gene expression in patients with breast cancer. 25(oh)d 151-158 vitamin D receptor Homo sapiens 74-77 30668751-10 2019 Higher 25(OH)D was not associated with incident CKD overall, but it was associated with lower odds of incident CKD among participants with the GG or GT genotype at rs7041 in the gene encoding DBP [OR, 0.69 per 5 ng/mL higher 25(OH)D; 95% CI, 0.51 to 0.93; P-interaction = 0.005]. 25(oh)d 7-14 D-box binding PAR bZIP transcription factor Homo sapiens 192-195 30668751-10 2019 Higher 25(OH)D was not associated with incident CKD overall, but it was associated with lower odds of incident CKD among participants with the GG or GT genotype at rs7041 in the gene encoding DBP [OR, 0.69 per 5 ng/mL higher 25(OH)D; 95% CI, 0.51 to 0.93; P-interaction = 0.005]. 25(oh)d 225-232 D-box binding PAR bZIP transcription factor Homo sapiens 192-195 30668751-12 2019 CONCLUSION: These findings support a potential benefit of higher 25(OH)D for kidney health in black Americans with diabetes or specific variants in DBP. 25(oh)d 65-72 D-box binding PAR bZIP transcription factor Homo sapiens 148-151 31137600-3 2019 The aim of the study was to assess the association between Vit D levels (expressed as 25(OH)D serum levels) and insulin resistance in patients with OSAS. 25(oh)d 86-93 vitrin Homo sapiens 59-62 31137600-3 2019 The aim of the study was to assess the association between Vit D levels (expressed as 25(OH)D serum levels) and insulin resistance in patients with OSAS. 25(oh)d 86-93 insulin Homo sapiens 112-119 31137600-9 2019 Regression analysis demonstrated a negative association of 25(OH)D levels (beta = -0.048, odds ratio [OR]: 0.953, 95% confidence interval [CI]: 0.913-0.995, p = 0.030) and a positive association of BMI (beta = 0.110, OR: 1.116, 95% CI: 1.007-1.237, p = 0.036) with insulin resistance. 25(oh)d 59-66 insulin Homo sapiens 265-272 31137600-11 2019 Both low 25(OH)D levels and high BMI were associated with the risk of insulin resistance in this population. 25(oh)d 9-16 insulin Homo sapiens 70-77 30833174-6 2019 The serum levels of 25(OH)D were indirectly and significantly correlated with the tissue levels of both VDR and ER-alpha gene expression. 25(oh)d 20-27 vitamin D receptor Homo sapiens 104-107 30833174-6 2019 The serum levels of 25(OH)D were indirectly and significantly correlated with the tissue levels of both VDR and ER-alpha gene expression. 25(oh)d 20-27 estrogen receptor 1 Homo sapiens 112-120