PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 18063724-10 2008 In contrast, mutagenesis of the analogous Cys615 in hSGLT2 produced the opposite effect, a decrease in IC(50) for phlorizin and sergliflozin-A. sergliflozin-A 128-142 solute carrier family 5 member 2 Homo sapiens 52-58 18063724-4 2008 In this study, we examined the inhibition of alpha-methyl-d-glucopyranose transport by phlorizin and a new candidate drug, sergliflozin-A [(2-[4-methoxyphenyl]methyl)phenyl beta-d-glucopyranoside], in COS-7 cells expressing hSGLT1 and hSGLT2. sergliflozin-A 123-137 solute carrier family 5 member 1 Homo sapiens 224-230 27025345-0 2016 Modification on the O-glucoside of Sergliflozin-A: A new strategy for SGLT2 inhibitor design. sergliflozin-A 35-49 solute carrier family 5 member 2 Homo sapiens 70-75 18063724-4 2008 In this study, we examined the inhibition of alpha-methyl-d-glucopyranose transport by phlorizin and a new candidate drug, sergliflozin-A [(2-[4-methoxyphenyl]methyl)phenyl beta-d-glucopyranoside], in COS-7 cells expressing hSGLT1 and hSGLT2. sergliflozin-A 123-137 solute carrier family 5 member 2 Homo sapiens 235-241 18063724-6 2008 Inhibition by sergliflozin-A was also competitive, with K(i) values of 1 muM in hSGLT1 and 20 nM in hSGLT2. sergliflozin-A 14-28 latexin Homo sapiens 73-76 18063724-6 2008 Inhibition by sergliflozin-A was also competitive, with K(i) values of 1 muM in hSGLT1 and 20 nM in hSGLT2. sergliflozin-A 14-28 solute carrier family 5 member 1 Homo sapiens 80-86 18063724-6 2008 Inhibition by sergliflozin-A was also competitive, with K(i) values of 1 muM in hSGLT1 and 20 nM in hSGLT2. sergliflozin-A 14-28 solute carrier family 5 member 2 Homo sapiens 100-106 17050778-5 2007 By examining a Chinese hamster ovary-K1 cell line stably expressing either human SGLT2 or human high-affinity sodium glucose cotransporter (SGLT1), we found sergliflozin-A (active form) to be a highly selective and potent inhibitor of human SGLT2. sergliflozin-A 157-171 solute carrier family 5 member 2 Homo sapiens 81-86 17050778-5 2007 By examining a Chinese hamster ovary-K1 cell line stably expressing either human SGLT2 or human high-affinity sodium glucose cotransporter (SGLT1), we found sergliflozin-A (active form) to be a highly selective and potent inhibitor of human SGLT2. sergliflozin-A 157-171 solute carrier family 5 member 1 Homo sapiens 140-145 17050778-5 2007 By examining a Chinese hamster ovary-K1 cell line stably expressing either human SGLT2 or human high-affinity sodium glucose cotransporter (SGLT1), we found sergliflozin-A (active form) to be a highly selective and potent inhibitor of human SGLT2. sergliflozin-A 157-171 solute carrier family 5 member 2 Homo sapiens 241-246