PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
6893684-2	1980	FMN (10 mumol/l) markedly stimulated the reaction, and the optimal concentration of resazurin was 50 mumol/l.	resazurin	84-93	formin 1	Homo sapiens	0-3
33372757-4	2021	We also employ resazurin, which changes from blue to pink in the presence of growing bacteria, to accelerate and enable colorimetric readout in our AST.	resazurin	15-24	solute carrier family 17 member 5	Homo sapiens	148-151
657494-4	1978	The hydrogen in the generated NADH is transferred by diaphorase (EC 1.6.4.3) to resazurin to yield resorfin, the fluorophore.	resazurin	80-89	dihydrolipoamide dehydrogenase	Homo sapiens	53-63
33710182-5	2021	With the participation of another enzyme, diaphorase, the multienzymatic coupling system was constructed, which realizes the output of fluorescence signals from TMAO input using resazurin as a probe, thus laying the foundation for fluorescent assay.	resazurin	178-187	dihydrolipoamide dehydrogenase	Homo sapiens	42-52
32542096-7	2020	Finally, in vitro cytotoxicity experiments were conducted with anti-moesin antibodies by the resazurin reduction assay method.	resazurin	93-102	moesin	Homo sapiens	68-74
32751068-3	2020	Cell Viability and luciferase assay of 4T1-Luc2 cancer cells in the presence of anti-VCAM-1 ssDNA or anti-IL4Ralpha RNA aptamers was assessed by monitoring the changes in the absorbance and the fluorescence of Alamar blue dye.	resazurin	210-221	vascular cell adhesion molecule 1	Mus musculus	85-91
32268159-3	2020	The cell viability using resazurin assay indicated that I1, I2 e I3 had moderate to low capacity to reduce the viability of colorectal cells (Caco-2), liver cells (HepG2), lung cells (GM 07492-A and A549) and endothelial cells (HU-VE-C).	resazurin	25-34	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	56-67
33341310-5	2021	METHODS: The resazurin reduction assay was employed to evaluate the cytotoxicity of PU-1 on sensitive and their corresponding drug-resistant cell lines (overexpressing P-glycoprotein, BCRP, ABCB5, DeltaEGFR, or TP53 knockout).	resazurin	13-22	Spi-1 proto-oncogene	Homo sapiens	84-88
24913741-5	2014	Subsequently, NADH is used in the conversion of resazurin to fluorescent resorufin by DI.	resazurin	48-57	dihydrolipoamide dehydrogenase	Homo sapiens	86-88
31635212-10	2019	These early-onset hHAP2Y2R-mediated signaling responses in Cav-1-expressing and Cav-1 KD 1321N1 correlated with changes in cell viability (via a resazurin-based method) and apoptosis (via caspase-9 expression).	resazurin	145-154	caveolin 1	Homo sapiens	59-64
31302129-7	2019	We hypothesize that the positively charged insulin at low pH can combine with the negatively charged resazurin due to electrostatic interaction, through which resazurin inhibited the process of insulin fibrillation.	resazurin	159-168	insulin	Homo sapiens	43-50
29047383-9	2017	Affect of the p32 inhibitor on glioma cell proliferation was assessed by Alamar Blue assay, and affect on metabolism was examined by measuring lactate secretion.	resazurin	73-84	inhibitor of growth family member 2	Homo sapiens	14-17
25645193-2	2015	METHODS: The protection and underlying mechanisms were detected in CYP2E1 overexpression primary rat hepatocytes by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, alamar blue assay, CYP2E1 inhibition assay and glutathione assay.	resazurin	190-201	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	67-73
28962321-3	2014	Low doses of hydroquinone (227-454 muM) reduce the viability of fibroblasts and HCT116 cells, determined by resazurin conversion, and induce genotoxic damage (DNA strand breaks), as assessed by alkaline comet assays.	resazurin	108-117	latexin	Homo sapiens	35-38
31722745-6	2019	Effects of IL-1Ra in rescuing IL-1alpha-induced catabolism in cartilage monoculture and cartilage-synovium co-culture were assessed by measuring loss of glycosaminoglycans (GAGs) and collagen using DMMB (dimethyl-methylene blue) and hydroxyproline assays, respectively, nitric oxide (NO) release using Griess assay, cell viability by fluorescence staining, metabolic activity using Alamar blue, and proteoglycan biosynthesis by radiolabel incorporation.	resazurin	382-393	interleukin 1 alpha	Bos taurus	30-39
29677363-9	2018	However, using alamarBlue, a decrease in the metabolic activity of the HCECs exposed to denatured lysozyme was detected.	resazurin	15-25	lysozyme	Homo sapiens	98-106
27078679-3	2016	In this study, we discuss these interference challenges and highlight the specific case of the diaphorase/resazurin system that can be coupled to enzymes utilizing NADH or NADPH.	resazurin	106-115	dihydrolipoamide dehydrogenase	Homo sapiens	95-105
27078681-3	2016	By coupling dehydrogenases to diaphorase, which utilizes NAD(P)H to produce the fluorescent molecule resorufin from resazurin, the assay can be red-shifted into a spectral region that reduces interference from compound libraries.	resazurin	116-125	dihydrolipoamide dehydrogenase	Homo sapiens	30-40
26504251-0	2015	Synthesis of F-18 labeled resazurin by direct electrophilic fluorination.	resazurin	26-35	mastermind like domain containing 1	Homo sapiens	13-17
26504251-1	2015	We present the synthesis and characterization of F18-labeled fluorinated derivatives of resazurin, a probe for cell viability.	resazurin	88-97	mastermind like domain containing 1	Homo sapiens	49-52
24367766-6	2013	As low as 4.4 muM resazurin was sufficient for a 10-fold reduction in F. tularensis growth.	resazurin	18-27	latexin	Homo sapiens	14-17
24299989-5	2014	Via coupled enzyme reactions involving ADP-hexokinase, glucose-6-phosphate dehydrogenase, and diaphorase, the ADP is utilized for conversion of resazurin to resorufin, which is determined by fluorescence measurement.	resazurin	144-153	glucose-6-phosphate dehydrogenase	Homo sapiens	55-88
24299989-5	2014	Via coupled enzyme reactions involving ADP-hexokinase, glucose-6-phosphate dehydrogenase, and diaphorase, the ADP is utilized for conversion of resazurin to resorufin, which is determined by fluorescence measurement.	resazurin	144-153	dihydrolipoamide dehydrogenase	Homo sapiens	94-104
24367766-9	2013	Replication of F. tularensis in primary human macrophages and non-phagocytic cells was abolished following treatment with 44 muM resazurin indicating this compound could be an effective therapy for tularemia in vivo.	resazurin	129-138	latexin	Homo sapiens	125-128
22113454-5	2012	Leptin significantly decreased the percentage of resazurin reduction in all studied concentrations while there was only a slight or non significant difference in RM1cell proliferation in the presence of insulin or insulin combined with leptin when compared with control.	resazurin	49-58	leptin	Mus musculus	0-6
20552314-4	2011	NF and GFAP directed flow cytometry was able to identify several of the test chemicals as being specifically neurotoxic (chloroquine, nicotine) or astrocytoxic (atropine, chloramphenicol) via quantification of cell death in the NT2.N/A model at cytotoxic concentrations using the resazurin cytotoxicity assay.	resazurin	280-289	glial fibrillary acidic protein	Homo sapiens	7-11
21693178-6	2011	Twenty-four hours after treatment, the resazurin assay showed an EC50 value (6.3 muM) which was about one decade above the value obtained from oxygen consumption rate (0.37 muM) and extracellular acidification rate (0.72 muM), measured with the workstation.	resazurin	39-48	latexin	Homo sapiens	81-84
21693178-6	2011	Twenty-four hours after treatment, the resazurin assay showed an EC50 value (6.3 muM) which was about one decade above the value obtained from oxygen consumption rate (0.37 muM) and extracellular acidification rate (0.72 muM), measured with the workstation.	resazurin	39-48	latexin	Homo sapiens	173-176
21693178-6	2011	Twenty-four hours after treatment, the resazurin assay showed an EC50 value (6.3 muM) which was about one decade above the value obtained from oxygen consumption rate (0.37 muM) and extracellular acidification rate (0.72 muM), measured with the workstation.	resazurin	39-48	latexin	Homo sapiens	173-176
17055645-7	2006	In the resazurin-reduction test, the PKR inhibitor (at 0.1 and 0.3 microM) concentration-dependently inhibited the tunicamycin-induced decrease in metabolic activity.	resazurin	7-16	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	37-40
20707388-10	2010	Alamar blue assays and light microscopy indicate that the compound protects cultured rat INS-1 cells against IAPP-induced toxicity.	resazurin	0-11	islet amyloid polypeptide	Rattus norvegicus	109-113
20935504-2	2010	Results showed that a screening strategy based on Alamar Blue underrepresented the viability of Bcl-xL-expressing cells relative to Akt-expressing cells, possibly due to metabolic differences between the two cell survival programs.	resazurin	50-61	BCL2 like 1	Homo sapiens	96-102
16142437-3	2005	TIMP-1 can also stimulate proliferation ([3H]thymidine incorporation) and cellular anabolic processes (Alamar Blue reduction).	resazurin	103-114	TIMP metallopeptidase inhibitor 1	Homo sapiens	0-6
11490350-7	2001	The vital dye alamar blue assessed proliferation of ApoJ + FBS- or VEGF-stimulated HUVECs.	resazurin	14-25	clusterin	Homo sapiens	52-56
15606900-7	2005	In parallel, insulin protected cultured neurons against both glutamate toxicity and OGD, as assayed by mitochondrial reduction of Alamar Blue.	resazurin	130-141	insulin	Homo sapiens	13-20
15136165-3	2004	In this assay, cell death is measured by correlating the activity of extracellular G6PD to the reduction of resazurin to the fluorescent product, resorufin, via a coupled-enzyme reaction.	resazurin	108-117	glucose-6-phosphate dehydrogenase	Homo sapiens	83-87
15136165-4	2004	The coupled-enzyme reaction permits rapid signal amplification from small amounts of G6PD, an advantage over assays based on resazurin alone.	resazurin	125-134	glucose-6-phosphate dehydrogenase	Homo sapiens	85-89
16305310-5	2005	Toward that end, we describe a coupled enzyme assay format for the measurement of recombinant human NAD synthetase by employing lactate dehydrogenase in a cycling/amplification reaction linked ultimately to the fluorescence generation of resorufin from resazurin via diaphorase.	resazurin	253-262	NAD synthetase 1	Homo sapiens	100-114
34174847-2	2021	METHODS: AlamarBlue assays were performed to define cytotoxicity of BTKi against MCL cells, Jeko-1 and Mino.	resazurin	9-19	inhibitor of Bruton tyrosine kinase	Homo sapiens	68-72
20650087-6	1995	After correction of absorbance values, FBS and BSA added to culture medium were found to depress the reduction of alamarBlue in lung fibroblasts and mesothelial cells.	resazurin	114-124	albumin	Homo sapiens	47-50
8157999-4	1994	The pattern of concanavalin A (ConA) or anti-CD3 antibody-induced proliferative response of murine lymphocytes as assessed by Alamar Blue was similar to that of a [3H]thymidine assay.	resazurin	126-137	CD3 antigen, epsilon polypeptide	Mus musculus	45-48
22055953-3	1988	The HADH colour test of Gottesmann and Hamm was modified by replacing the electron-transmitter meldolablue by resazurin which results in a much higher colour stability after reaction with fresh meat extracts.	resazurin	110-119	hydroxyacyl-CoA dehydrogenase	Homo sapiens	4-8