PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
35204314-7	2022	Mechanistically, CCB counteracted oxidative stress in diabetic hearts by down-regulating NADPH oxidases, reducing reactive oxygen species (ROS) generation and modulating the sirtuin-1 (SIRT1)/ nuclear factor E2-related factor 2 (Nrf2) signalling pathway, overall improving antioxidant defence.	ccb	17-20	sirtuin 1	Rattus norvegicus	174-183
34182453-11	2021	CBp can replace up to half of cCB without significantly reducing the quality of tire rubber.	ccb	30-33	CREB binding protein	Homo sapiens	0-3
35204314-7	2022	Mechanistically, CCB counteracted oxidative stress in diabetic hearts by down-regulating NADPH oxidases, reducing reactive oxygen species (ROS) generation and modulating the sirtuin-1 (SIRT1)/ nuclear factor E2-related factor 2 (Nrf2) signalling pathway, overall improving antioxidant defence.	ccb	17-20	sirtuin 1	Rattus norvegicus	185-190
35204314-7	2022	Mechanistically, CCB counteracted oxidative stress in diabetic hearts by down-regulating NADPH oxidases, reducing reactive oxygen species (ROS) generation and modulating the sirtuin-1 (SIRT1)/ nuclear factor E2-related factor 2 (Nrf2) signalling pathway, overall improving antioxidant defence.	ccb	17-20	NFE2 like bZIP transcription factor 2	Rattus norvegicus	193-227
35204314-7	2022	Mechanistically, CCB counteracted oxidative stress in diabetic hearts by down-regulating NADPH oxidases, reducing reactive oxygen species (ROS) generation and modulating the sirtuin-1 (SIRT1)/ nuclear factor E2-related factor 2 (Nrf2) signalling pathway, overall improving antioxidant defence.	ccb	17-20	NFE2 like bZIP transcription factor 2	Rattus norvegicus	229-233
3263528-2	1988	We propose that there is a linkage between the two loci on the X-chromosome determining CCB and glucose-6-phosphate dehydrogenase (G6PD), based on our study of a high incidence of G6PD deficiency in 156 male cases with CCB.	ccb	219-222	glucose-6-phosphate dehydrogenase	Homo sapiens	96-129
3263528-2	1988	We propose that there is a linkage between the two loci on the X-chromosome determining CCB and glucose-6-phosphate dehydrogenase (G6PD), based on our study of a high incidence of G6PD deficiency in 156 male cases with CCB.	ccb	219-222	glucose-6-phosphate dehydrogenase	Homo sapiens	131-135
31754011-12	2020	Interestingly, ccb also interacts with actin and the actin nucleator spire The data revealed that this interaction plays a key role in the development of axonal connections within the ellipsoid body.	ccb	15-18	Actin 79B	Drosophila melanogaster	39-44
31754011-12	2020	Interestingly, ccb also interacts with actin and the actin nucleator spire The data revealed that this interaction plays a key role in the development of axonal connections within the ellipsoid body.	ccb	15-18	Actin 79B	Drosophila melanogaster	53-58
31754011-12	2020	Interestingly, ccb also interacts with actin and the actin nucleator spire The data revealed that this interaction plays a key role in the development of axonal connections within the ellipsoid body.	ccb	15-18	spire	Drosophila melanogaster	69-74
31277493-1	2019	In the present research, treatment of contaminated groundwater via adsorption of As(V) with an initial concentration of 50.99 microg/L using chitosan-coated bentonite (CCB) was investigated.	ccb	168-171	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	81-86
31374372-6	2020	The adsorption kinetics of Pb(II) and Cd(II) onto CCB was well described by the pseudo-second-order kinetic model.	ccb	50-53	submaxillary gland androgen regulated protein 3B	Homo sapiens	27-33
31374372-7	2020	The maximum Langmuir adsorption capacity of CCB was found to be 389.78 and 115.96 mg g-1 for Pb(II) and Cd(II), respectively.	ccb	44-47	submaxillary gland androgen regulated protein 3B	Homo sapiens	93-99
31600033-11	2019	The corresponding CCB had weak-to-moderate p16 staining in <70% of cells (range, 5%-60% of cells) in 17 cases, 4 had weak-to-moderate diffuse staining, and 4 were acellular.	ccb	18-21	cyclin dependent kinase inhibitor 2A	Homo sapiens	43-46
31600033-12	2019	The percentage of p16-positive cells was significantly higher with FFCB than with CCB (formalin: 94% +- 2%; CytoLyt, 38% +- 7%; 2-tailed, paired Student t test; P < .001; Fisher exact test, P < .001).	ccb	82-85	cyclin dependent kinase inhibitor 2A	Homo sapiens	18-21
31277493-6	2019	Thermodynamics study shows that the As(V) adsorption is non-spontaneous (DeltaG0 >= 0) and endothermic (DeltaH0 = 8.31 J/mol) that would result in an increase in randomness (DeltaS0 = 29.10 kJ/mol K) within the CCB-solution interface.	ccb	211-214	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	36-41
31277493-8	2019	Results of the present research serve as a tool to determine whether CCB is an environmentally safe and cost effective material that could be utilized in a permeable reactive barrier system for the remediation of As(V) from contaminated groundwater.	ccb	69-72	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	213-218
25515296-7	2014	RESULTS: Apart from hyperlipidemia, CCB also induced hyperglycemia with marked increase in hepatic enzymes: gamma-glutamyl transferase (GGT), alanine and aspartate aminotransferase (ALT and AST); and vascular biomarkers: uric acid (UA), phosphorus and alkaline phosphatase (ALP).	ccb	36-39	gamma-glutamyltransferase 1	Rattus norvegicus	108-134
29309048-4	2018	CCB therapy led to changes in circulating B cells that were detectable after the first cycle of therapy and characterized by a decline in circulating B cells and an increase in CD21lo B cells and plasmablasts.	ccb	0-3	complement C3d receptor 2	Homo sapiens	177-181
29309048-6	2018	CCB induced proliferation in the CD21lo compartment, and single-cell RNA sequencing identified B cell activation in cells with genomic profiles of CD21lo B cells in vivo.	ccb	0-3	complement C3d receptor 2	Homo sapiens	33-37
30144085-5	2018	The ACV and the ACV-MP (66.67 muM) inhibited a cytopathic effect (CPE) induced by the CyHV-3 virus in the CCB (ACV by 66%, ACV-MP by 58%) and the KF1 (ACV by 25%, ACV-MP by 37%).	ccb	106-109	latexin	Homo sapiens	30-33
25515296-7	2014	RESULTS: Apart from hyperlipidemia, CCB also induced hyperglycemia with marked increase in hepatic enzymes: gamma-glutamyl transferase (GGT), alanine and aspartate aminotransferase (ALT and AST); and vascular biomarkers: uric acid (UA), phosphorus and alkaline phosphatase (ALP).	ccb	36-39	gamma-glutamyltransferase 1	Rattus norvegicus	136-139
25515296-7	2014	RESULTS: Apart from hyperlipidemia, CCB also induced hyperglycemia with marked increase in hepatic enzymes: gamma-glutamyl transferase (GGT), alanine and aspartate aminotransferase (ALT and AST); and vascular biomarkers: uric acid (UA), phosphorus and alkaline phosphatase (ALP).	ccb	36-39	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	154-180
23674129-9	2013	In conclusion, the newly synthesized asymmetrical DHP compounds showed promising MDR reversal and antitumoral activities with low CCB effects and could be of therapeutic value in drug resistant cancer.	ccb	130-133	dihydropyrimidinase	Homo sapiens	50-53
12104094-9	2002	CONCLUSIONS: These findings demonstrate that CCB increases the production of NO and TNF-alpha by rIFN-gamma-primed peritoneal macrophages and suggest that NF-kappa B plays a critical role in mediating these effects of CCB.	ccb	218-221	interferon gamma	Rattus norvegicus	97-107
23946229-11	2013	Mice on high-cholesterol diet had elevated plasma levels of sVCAM-1, sE-selectin and SAA, which was further increased in the CCB group.	ccb	125-128	serum amyloid A cluster	Mus musculus	69-88
16728347-5	2006	Unexpectedly, the expression of activator isoform of transcription factor cAMP-responsive element modulator (CREM) mRNA increased together with transition protein 2 and protamine 2 mRNA in drug-treated mice testes, suggesting that CCB may deregulate expression of activator isoform of CREM in male germ cells and that spermatogenic defect following CCB treatment may attribute to ectopic expression of CREM-dependent gene battery in testis.	ccb	231-234	cAMP responsive element modulator	Mus musculus	74-107
16728347-5	2006	Unexpectedly, the expression of activator isoform of transcription factor cAMP-responsive element modulator (CREM) mRNA increased together with transition protein 2 and protamine 2 mRNA in drug-treated mice testes, suggesting that CCB may deregulate expression of activator isoform of CREM in male germ cells and that spermatogenic defect following CCB treatment may attribute to ectopic expression of CREM-dependent gene battery in testis.	ccb	231-234	cAMP responsive element modulator	Mus musculus	109-113
16728347-5	2006	Unexpectedly, the expression of activator isoform of transcription factor cAMP-responsive element modulator (CREM) mRNA increased together with transition protein 2 and protamine 2 mRNA in drug-treated mice testes, suggesting that CCB may deregulate expression of activator isoform of CREM in male germ cells and that spermatogenic defect following CCB treatment may attribute to ectopic expression of CREM-dependent gene battery in testis.	ccb	231-234	transition protein 2	Mus musculus	144-164
16728347-5	2006	Unexpectedly, the expression of activator isoform of transcription factor cAMP-responsive element modulator (CREM) mRNA increased together with transition protein 2 and protamine 2 mRNA in drug-treated mice testes, suggesting that CCB may deregulate expression of activator isoform of CREM in male germ cells and that spermatogenic defect following CCB treatment may attribute to ectopic expression of CREM-dependent gene battery in testis.	ccb	231-234	protamine 2	Mus musculus	169-180
16728347-5	2006	Unexpectedly, the expression of activator isoform of transcription factor cAMP-responsive element modulator (CREM) mRNA increased together with transition protein 2 and protamine 2 mRNA in drug-treated mice testes, suggesting that CCB may deregulate expression of activator isoform of CREM in male germ cells and that spermatogenic defect following CCB treatment may attribute to ectopic expression of CREM-dependent gene battery in testis.	ccb	231-234	cAMP responsive element modulator	Mus musculus	285-289
16728347-5	2006	Unexpectedly, the expression of activator isoform of transcription factor cAMP-responsive element modulator (CREM) mRNA increased together with transition protein 2 and protamine 2 mRNA in drug-treated mice testes, suggesting that CCB may deregulate expression of activator isoform of CREM in male germ cells and that spermatogenic defect following CCB treatment may attribute to ectopic expression of CREM-dependent gene battery in testis.	ccb	231-234	cAMP responsive element modulator	Mus musculus	285-289
16728347-5	2006	Unexpectedly, the expression of activator isoform of transcription factor cAMP-responsive element modulator (CREM) mRNA increased together with transition protein 2 and protamine 2 mRNA in drug-treated mice testes, suggesting that CCB may deregulate expression of activator isoform of CREM in male germ cells and that spermatogenic defect following CCB treatment may attribute to ectopic expression of CREM-dependent gene battery in testis.	ccb	349-352	cAMP responsive element modulator	Mus musculus	74-107
16728347-5	2006	Unexpectedly, the expression of activator isoform of transcription factor cAMP-responsive element modulator (CREM) mRNA increased together with transition protein 2 and protamine 2 mRNA in drug-treated mice testes, suggesting that CCB may deregulate expression of activator isoform of CREM in male germ cells and that spermatogenic defect following CCB treatment may attribute to ectopic expression of CREM-dependent gene battery in testis.	ccb	349-352	cAMP responsive element modulator	Mus musculus	109-113
14570823-9	2003	Photoaffinity labeling of the NT receptor NTR1 was enhanced in CCB-treated cells.	ccb	63-66	neurotensin receptor 1	Homo sapiens	42-46
12104094-1	2002	BACKGROUND: CancerB (CCB, IMSF-5), herbal combination, may be able to stimulate potential toxic mediators such as nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) in isolated mouse peritoneal macrophages.	ccb	21-24	tumor necrosis factor	Mus musculus	136-163
12104094-1	2002	BACKGROUND: CancerB (CCB, IMSF-5), herbal combination, may be able to stimulate potential toxic mediators such as nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) in isolated mouse peritoneal macrophages.	ccb	21-24	tumor necrosis factor	Mus musculus	165-174
12104094-4	2002	RESULTS: CCB had no effect on NO production by itself, but CCB alone did stimulate the production of TNF-alpha.	ccb	59-62	tumor necrosis factor	Mus musculus	101-110
12104094-5	2002	When CCB was used in combination with recombinant interferon-gamma (rIFN-gamma), there was a marked cooperative induction of NO production, TNF-alpha production and NF-kappa B activation.	ccb	5-8	interferon gamma	Mus musculus	50-66
12104094-5	2002	When CCB was used in combination with recombinant interferon-gamma (rIFN-gamma), there was a marked cooperative induction of NO production, TNF-alpha production and NF-kappa B activation.	ccb	5-8	interferon gamma	Rattus norvegicus	68-78
12104094-5	2002	When CCB was used in combination with recombinant interferon-gamma (rIFN-gamma), there was a marked cooperative induction of NO production, TNF-alpha production and NF-kappa B activation.	ccb	5-8	tumor necrosis factor	Mus musculus	140-149
12104094-5	2002	When CCB was used in combination with recombinant interferon-gamma (rIFN-gamma), there was a marked cooperative induction of NO production, TNF-alpha production and NF-kappa B activation.	ccb	5-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	165-175
12104094-9	2002	CONCLUSIONS: These findings demonstrate that CCB increases the production of NO and TNF-alpha by rIFN-gamma-primed peritoneal macrophages and suggest that NF-kappa B plays a critical role in mediating these effects of CCB.	ccb	45-48	tumor necrosis factor	Mus musculus	84-93
12104094-9	2002	CONCLUSIONS: These findings demonstrate that CCB increases the production of NO and TNF-alpha by rIFN-gamma-primed peritoneal macrophages and suggest that NF-kappa B plays a critical role in mediating these effects of CCB.	ccb	45-48	interferon gamma	Rattus norvegicus	97-107
12104094-9	2002	CONCLUSIONS: These findings demonstrate that CCB increases the production of NO and TNF-alpha by rIFN-gamma-primed peritoneal macrophages and suggest that NF-kappa B plays a critical role in mediating these effects of CCB.	ccb	45-48	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	155-165
12104094-9	2002	CONCLUSIONS: These findings demonstrate that CCB increases the production of NO and TNF-alpha by rIFN-gamma-primed peritoneal macrophages and suggest that NF-kappa B plays a critical role in mediating these effects of CCB.	ccb	218-221	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	155-165
14646473-7	1998	Thus, FN fragments containing the CCB and adjacent domains generated in the kidneys of PHN rats may be involved in the evolution of the renal injury.	ccb	34-37	fibronectin 1	Rattus norvegicus	6-8