PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 31754011-12 2020 Interestingly, ccb also interacts with actin and the actin nucleator spire The data revealed that this interaction plays a key role in the development of axonal connections within the ellipsoid body. ccb 15-18 Actin 79B Drosophila melanogaster 39-44 34182453-11 2021 CBp can replace up to half of cCB without significantly reducing the quality of tire rubber. ccb 30-33 CREB binding protein Homo sapiens 0-3 35204314-7 2022 Mechanistically, CCB counteracted oxidative stress in diabetic hearts by down-regulating NADPH oxidases, reducing reactive oxygen species (ROS) generation and modulating the sirtuin-1 (SIRT1)/ nuclear factor E2-related factor 2 (Nrf2) signalling pathway, overall improving antioxidant defence. ccb 17-20 sirtuin 1 Rattus norvegicus 174-183 35204314-7 2022 Mechanistically, CCB counteracted oxidative stress in diabetic hearts by down-regulating NADPH oxidases, reducing reactive oxygen species (ROS) generation and modulating the sirtuin-1 (SIRT1)/ nuclear factor E2-related factor 2 (Nrf2) signalling pathway, overall improving antioxidant defence. ccb 17-20 sirtuin 1 Rattus norvegicus 185-190 35204314-7 2022 Mechanistically, CCB counteracted oxidative stress in diabetic hearts by down-regulating NADPH oxidases, reducing reactive oxygen species (ROS) generation and modulating the sirtuin-1 (SIRT1)/ nuclear factor E2-related factor 2 (Nrf2) signalling pathway, overall improving antioxidant defence. ccb 17-20 NFE2 like bZIP transcription factor 2 Rattus norvegicus 193-227 35204314-7 2022 Mechanistically, CCB counteracted oxidative stress in diabetic hearts by down-regulating NADPH oxidases, reducing reactive oxygen species (ROS) generation and modulating the sirtuin-1 (SIRT1)/ nuclear factor E2-related factor 2 (Nrf2) signalling pathway, overall improving antioxidant defence. ccb 17-20 NFE2 like bZIP transcription factor 2 Rattus norvegicus 229-233 3263528-2 1988 We propose that there is a linkage between the two loci on the X-chromosome determining CCB and glucose-6-phosphate dehydrogenase (G6PD), based on our study of a high incidence of G6PD deficiency in 156 male cases with CCB. ccb 219-222 glucose-6-phosphate dehydrogenase Homo sapiens 96-129 3263528-2 1988 We propose that there is a linkage between the two loci on the X-chromosome determining CCB and glucose-6-phosphate dehydrogenase (G6PD), based on our study of a high incidence of G6PD deficiency in 156 male cases with CCB. ccb 219-222 glucose-6-phosphate dehydrogenase Homo sapiens 131-135 31754011-12 2020 Interestingly, ccb also interacts with actin and the actin nucleator spire The data revealed that this interaction plays a key role in the development of axonal connections within the ellipsoid body. ccb 15-18 Actin 79B Drosophila melanogaster 53-58 31754011-12 2020 Interestingly, ccb also interacts with actin and the actin nucleator spire The data revealed that this interaction plays a key role in the development of axonal connections within the ellipsoid body. ccb 15-18 spire Drosophila melanogaster 69-74 14646473-7 1998 Thus, FN fragments containing the CCB and adjacent domains generated in the kidneys of PHN rats may be involved in the evolution of the renal injury. ccb 34-37 fibronectin 1 Rattus norvegicus 6-8 31600033-11 2019 The corresponding CCB had weak-to-moderate p16 staining in <70% of cells (range, 5%-60% of cells) in 17 cases, 4 had weak-to-moderate diffuse staining, and 4 were acellular. ccb 18-21 cyclin dependent kinase inhibitor 2A Homo sapiens 43-46 31600033-12 2019 The percentage of p16-positive cells was significantly higher with FFCB than with CCB (formalin: 94% +- 2%; CytoLyt, 38% +- 7%; 2-tailed, paired Student t test; P < .001; Fisher exact test, P < .001). ccb 82-85 cyclin dependent kinase inhibitor 2A Homo sapiens 18-21 30144085-5 2018 The ACV and the ACV-MP (66.67 muM) inhibited a cytopathic effect (CPE) induced by the CyHV-3 virus in the CCB (ACV by 66%, ACV-MP by 58%) and the KF1 (ACV by 25%, ACV-MP by 37%). ccb 106-109 latexin Homo sapiens 30-33 29309048-4 2018 CCB therapy led to changes in circulating B cells that were detectable after the first cycle of therapy and characterized by a decline in circulating B cells and an increase in CD21lo B cells and plasmablasts. ccb 0-3 complement C3d receptor 2 Homo sapiens 177-181 29309048-6 2018 CCB induced proliferation in the CD21lo compartment, and single-cell RNA sequencing identified B cell activation in cells with genomic profiles of CD21lo B cells in vivo. ccb 0-3 complement C3d receptor 2 Homo sapiens 33-37 23674129-9 2013 In conclusion, the newly synthesized asymmetrical DHP compounds showed promising MDR reversal and antitumoral activities with low CCB effects and could be of therapeutic value in drug resistant cancer. ccb 130-133 dihydropyrimidinase Homo sapiens 50-53 14570823-9 2003 Photoaffinity labeling of the NT receptor NTR1 was enhanced in CCB-treated cells. ccb 63-66 neurotensin receptor 1 Homo sapiens 42-46 12104094-9 2002 CONCLUSIONS: These findings demonstrate that CCB increases the production of NO and TNF-alpha by rIFN-gamma-primed peritoneal macrophages and suggest that NF-kappa B plays a critical role in mediating these effects of CCB. ccb 218-221 interferon gamma Rattus norvegicus 97-107 12104094-9 2002 CONCLUSIONS: These findings demonstrate that CCB increases the production of NO and TNF-alpha by rIFN-gamma-primed peritoneal macrophages and suggest that NF-kappa B plays a critical role in mediating these effects of CCB. ccb 218-221 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 155-165 31374372-6 2020 The adsorption kinetics of Pb(II) and Cd(II) onto CCB was well described by the pseudo-second-order kinetic model. ccb 50-53 submaxillary gland androgen regulated protein 3B Homo sapiens 27-33 31374372-7 2020 The maximum Langmuir adsorption capacity of CCB was found to be 389.78 and 115.96 mg g-1 for Pb(II) and Cd(II), respectively. ccb 44-47 submaxillary gland androgen regulated protein 3B Homo sapiens 93-99 31277493-1 2019 In the present research, treatment of contaminated groundwater via adsorption of As(V) with an initial concentration of 50.99 microg/L using chitosan-coated bentonite (CCB) was investigated. ccb 168-171 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 81-86 31277493-6 2019 Thermodynamics study shows that the As(V) adsorption is non-spontaneous (DeltaG0 >= 0) and endothermic (DeltaH0 = 8.31 J/mol) that would result in an increase in randomness (DeltaS0 = 29.10 kJ/mol K) within the CCB-solution interface. ccb 211-214 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 36-41 31277493-8 2019 Results of the present research serve as a tool to determine whether CCB is an environmentally safe and cost effective material that could be utilized in a permeable reactive barrier system for the remediation of As(V) from contaminated groundwater. ccb 69-72 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 213-218 25515296-7 2014 RESULTS: Apart from hyperlipidemia, CCB also induced hyperglycemia with marked increase in hepatic enzymes: gamma-glutamyl transferase (GGT), alanine and aspartate aminotransferase (ALT and AST); and vascular biomarkers: uric acid (UA), phosphorus and alkaline phosphatase (ALP). ccb 36-39 gamma-glutamyltransferase 1 Rattus norvegicus 108-134 25515296-7 2014 RESULTS: Apart from hyperlipidemia, CCB also induced hyperglycemia with marked increase in hepatic enzymes: gamma-glutamyl transferase (GGT), alanine and aspartate aminotransferase (ALT and AST); and vascular biomarkers: uric acid (UA), phosphorus and alkaline phosphatase (ALP). ccb 36-39 gamma-glutamyltransferase 1 Rattus norvegicus 136-139 25515296-7 2014 RESULTS: Apart from hyperlipidemia, CCB also induced hyperglycemia with marked increase in hepatic enzymes: gamma-glutamyl transferase (GGT), alanine and aspartate aminotransferase (ALT and AST); and vascular biomarkers: uric acid (UA), phosphorus and alkaline phosphatase (ALP). ccb 36-39 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 154-180 23946229-11 2013 Mice on high-cholesterol diet had elevated plasma levels of sVCAM-1, sE-selectin and SAA, which was further increased in the CCB group. ccb 125-128 serum amyloid A cluster Mus musculus 69-88 16728347-5 2006 Unexpectedly, the expression of activator isoform of transcription factor cAMP-responsive element modulator (CREM) mRNA increased together with transition protein 2 and protamine 2 mRNA in drug-treated mice testes, suggesting that CCB may deregulate expression of activator isoform of CREM in male germ cells and that spermatogenic defect following CCB treatment may attribute to ectopic expression of CREM-dependent gene battery in testis. ccb 231-234 cAMP responsive element modulator Mus musculus 74-107 16728347-5 2006 Unexpectedly, the expression of activator isoform of transcription factor cAMP-responsive element modulator (CREM) mRNA increased together with transition protein 2 and protamine 2 mRNA in drug-treated mice testes, suggesting that CCB may deregulate expression of activator isoform of CREM in male germ cells and that spermatogenic defect following CCB treatment may attribute to ectopic expression of CREM-dependent gene battery in testis. ccb 231-234 cAMP responsive element modulator Mus musculus 109-113 16728347-5 2006 Unexpectedly, the expression of activator isoform of transcription factor cAMP-responsive element modulator (CREM) mRNA increased together with transition protein 2 and protamine 2 mRNA in drug-treated mice testes, suggesting that CCB may deregulate expression of activator isoform of CREM in male germ cells and that spermatogenic defect following CCB treatment may attribute to ectopic expression of CREM-dependent gene battery in testis. ccb 231-234 transition protein 2 Mus musculus 144-164 16728347-5 2006 Unexpectedly, the expression of activator isoform of transcription factor cAMP-responsive element modulator (CREM) mRNA increased together with transition protein 2 and protamine 2 mRNA in drug-treated mice testes, suggesting that CCB may deregulate expression of activator isoform of CREM in male germ cells and that spermatogenic defect following CCB treatment may attribute to ectopic expression of CREM-dependent gene battery in testis. ccb 231-234 protamine 2 Mus musculus 169-180 16728347-5 2006 Unexpectedly, the expression of activator isoform of transcription factor cAMP-responsive element modulator (CREM) mRNA increased together with transition protein 2 and protamine 2 mRNA in drug-treated mice testes, suggesting that CCB may deregulate expression of activator isoform of CREM in male germ cells and that spermatogenic defect following CCB treatment may attribute to ectopic expression of CREM-dependent gene battery in testis. ccb 231-234 cAMP responsive element modulator Mus musculus 285-289 16728347-5 2006 Unexpectedly, the expression of activator isoform of transcription factor cAMP-responsive element modulator (CREM) mRNA increased together with transition protein 2 and protamine 2 mRNA in drug-treated mice testes, suggesting that CCB may deregulate expression of activator isoform of CREM in male germ cells and that spermatogenic defect following CCB treatment may attribute to ectopic expression of CREM-dependent gene battery in testis. ccb 231-234 cAMP responsive element modulator Mus musculus 285-289 16728347-5 2006 Unexpectedly, the expression of activator isoform of transcription factor cAMP-responsive element modulator (CREM) mRNA increased together with transition protein 2 and protamine 2 mRNA in drug-treated mice testes, suggesting that CCB may deregulate expression of activator isoform of CREM in male germ cells and that spermatogenic defect following CCB treatment may attribute to ectopic expression of CREM-dependent gene battery in testis. ccb 349-352 cAMP responsive element modulator Mus musculus 74-107 16728347-5 2006 Unexpectedly, the expression of activator isoform of transcription factor cAMP-responsive element modulator (CREM) mRNA increased together with transition protein 2 and protamine 2 mRNA in drug-treated mice testes, suggesting that CCB may deregulate expression of activator isoform of CREM in male germ cells and that spermatogenic defect following CCB treatment may attribute to ectopic expression of CREM-dependent gene battery in testis. ccb 349-352 cAMP responsive element modulator Mus musculus 109-113 12104094-1 2002 BACKGROUND: CancerB (CCB, IMSF-5), herbal combination, may be able to stimulate potential toxic mediators such as nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) in isolated mouse peritoneal macrophages. ccb 21-24 tumor necrosis factor Mus musculus 136-163 12104094-1 2002 BACKGROUND: CancerB (CCB, IMSF-5), herbal combination, may be able to stimulate potential toxic mediators such as nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) in isolated mouse peritoneal macrophages. ccb 21-24 tumor necrosis factor Mus musculus 165-174 12104094-4 2002 RESULTS: CCB had no effect on NO production by itself, but CCB alone did stimulate the production of TNF-alpha. ccb 59-62 tumor necrosis factor Mus musculus 101-110 12104094-5 2002 When CCB was used in combination with recombinant interferon-gamma (rIFN-gamma), there was a marked cooperative induction of NO production, TNF-alpha production and NF-kappa B activation. ccb 5-8 interferon gamma Mus musculus 50-66 12104094-5 2002 When CCB was used in combination with recombinant interferon-gamma (rIFN-gamma), there was a marked cooperative induction of NO production, TNF-alpha production and NF-kappa B activation. ccb 5-8 interferon gamma Rattus norvegicus 68-78 12104094-5 2002 When CCB was used in combination with recombinant interferon-gamma (rIFN-gamma), there was a marked cooperative induction of NO production, TNF-alpha production and NF-kappa B activation. ccb 5-8 tumor necrosis factor Mus musculus 140-149 12104094-5 2002 When CCB was used in combination with recombinant interferon-gamma (rIFN-gamma), there was a marked cooperative induction of NO production, TNF-alpha production and NF-kappa B activation. ccb 5-8 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 165-175 12104094-9 2002 CONCLUSIONS: These findings demonstrate that CCB increases the production of NO and TNF-alpha by rIFN-gamma-primed peritoneal macrophages and suggest that NF-kappa B plays a critical role in mediating these effects of CCB. ccb 45-48 tumor necrosis factor Mus musculus 84-93 12104094-9 2002 CONCLUSIONS: These findings demonstrate that CCB increases the production of NO and TNF-alpha by rIFN-gamma-primed peritoneal macrophages and suggest that NF-kappa B plays a critical role in mediating these effects of CCB. ccb 45-48 interferon gamma Rattus norvegicus 97-107 12104094-9 2002 CONCLUSIONS: These findings demonstrate that CCB increases the production of NO and TNF-alpha by rIFN-gamma-primed peritoneal macrophages and suggest that NF-kappa B plays a critical role in mediating these effects of CCB. ccb 45-48 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 155-165