PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 8941023-6 1996 RESULTS: After the consumption of the meal, the area under the curve (AUC) was 35% (95% confidence interval [CI]: 25%, 43%) lower for indocyanine green, 15% (CI: 6%, 24%) lower for t-PA antigen, and 11% (CI: 2%, 19%) lower for t-PA activity compared to the AUC after subjects abstained from food. Indocyanine Green 134-151 plasminogen activator, tissue type Homo sapiens 181-185 9308746-9 1997 A correlation was seen between the clearance of ICG and both those of u-PA antigen (r = 0.62; p <0.05) and u-PA activity (r = 0.57; p <0.05). Indocyanine Green 48-51 plasminogen activator, urokinase Homo sapiens 70-74 9308746-9 1997 A correlation was seen between the clearance of ICG and both those of u-PA antigen (r = 0.62; p <0.05) and u-PA activity (r = 0.57; p <0.05). Indocyanine Green 48-51 plasminogen activator, urokinase Homo sapiens 110-114 8941023-6 1996 RESULTS: After the consumption of the meal, the area under the curve (AUC) was 35% (95% confidence interval [CI]: 25%, 43%) lower for indocyanine green, 15% (CI: 6%, 24%) lower for t-PA antigen, and 11% (CI: 2%, 19%) lower for t-PA activity compared to the AUC after subjects abstained from food. Indocyanine Green 134-151 plasminogen activator, tissue type Homo sapiens 227-231 8810238-6 1996 Electrophoresis showed that ICG bound only to Apo-B, but not to the others. Indocyanine Green 28-31 apolipoprotein B Homo sapiens 46-51 8787473-6 1995 RESULTS: Results showed an increase of approximately 31% in the percent disappearance rate of indocyanine green with the addition of low-dose dopamine (4 micrograms.kg-1.min-1) (p < 0.01). Indocyanine Green 94-111 CD59 molecule (CD59 blood group) Homo sapiens 170-175 8738722-7 1996 In addition, IL-8 levels were higher in patients who died (p = 0.007), and correlated with biochemical and histological parameters, and severity of liver injury: serum aspartate aminotransferase, alanine aminotransferase, total bilirubin, prothrombin time, indocyanine green retention ratio, tumor necrosis factor-alpha and peripheral neutrophil count in patients with alcoholic hepatitis. Indocyanine Green 257-274 C-X-C motif chemokine ligand 8 Homo sapiens 13-17 7995194-4 1994 Endothelin-1 showed significant negative correlations with parameters of hepatic function, including indocyanine green clearance, serum albumin, and prothrombin time. Indocyanine Green 101-118 endothelin 1 Homo sapiens 0-12 7760665-2 1995 Fibrin tissue adhesive (FTA) and diode laser welding with indocyanine green-dyed fibrinogen were evaluated in tracheal anastomosis to reduce the number of sutures and to improve healing. Indocyanine Green 58-75 fibrinogen beta chain Homo sapiens 81-91 7806142-5 1995 Serum HGF levels in these diseases were significantly increased compared with those in the controls (P < .001), and exhibited a positive correlation with total bilirubin, indocyanine green (ICG) test (R15), asparate aminotransferase (AST), and a negative correlation with albumin and prothrombin time (P < .001). Indocyanine Green 174-191 hepatocyte growth factor Homo sapiens 6-9 7806142-5 1995 Serum HGF levels in these diseases were significantly increased compared with those in the controls (P < .001), and exhibited a positive correlation with total bilirubin, indocyanine green (ICG) test (R15), asparate aminotransferase (AST), and a negative correlation with albumin and prothrombin time (P < .001). Indocyanine Green 193-196 hepatocyte growth factor Homo sapiens 6-9 8334816-11 1993 The simulations using the new model indicate that the percentage of binding of Indocyanine Green to its transport protein (glutathione S-transferase) for removal in the bile will affect the estimation of the hepatic extraction ratio of Indocyanine Green. Indocyanine Green 79-96 microsomal glutathione S-transferase 1 Sus scrofa 123-148 7874270-5 1994 Significant correlations were found between u-PA plasma levels and the results of seven different liver function tests in three groups without associated HCC; u-PA antigen and prothrombin time (%), hepaplastin test (%), serum cholinesterase, serum albumin, serum total cholesterol, and indocyanine green clearance correlated negatively, while u-PA antigen and serum total bilirubin correlated positively. Indocyanine Green 286-303 plasminogen activator, urokinase Homo sapiens 44-48 7528080-6 1994 Serum c-erbB-2 protein levels were significantly correlated with the markers of hepatic functional reserve, the indocyanine green retention rate and the hepaplastin test. Indocyanine Green 112-129 erb-b2 receptor tyrosine kinase 2 Homo sapiens 6-14 7814798-5 1994 In cirrhosis, levels of macrophage colony stimulating factor correlated positively with the serum alanine aminotransferase levels (p < 0.05), total bilirubin levels (p < 0.05), and indocyanine green clearance (p < 0.05). Indocyanine Green 187-204 colony stimulating factor 1 Homo sapiens 24-60 7694064-2 1993 The elevation of s-IL6 on the first postoperative day was only correlated with preoperative values of indocyanine green retention test (ICG-R15) (r = 0.56, p < 0.01), and not concerned with any operative factors. Indocyanine Green 102-119 interleukin 6 Homo sapiens 19-22 8312872-6 1993 The pharmacokinetic analysis of these data showed that the decreased total plasma clearance of ICG in GAL and CCl4 rats results from both lowered influx across the sinusoidal plasma membrane of hepatocytes and the decreased hepatic plasma flow. Indocyanine Green 95-98 C-C motif chemokine ligand 4 Rattus norvegicus 110-114 7505994-0 1993 Loss of ICG uptake in the process of rat hepatocarcinogenesis correlates to the disappearance of glutathione-S-transferase alpha subunit. Indocyanine Green 8-11 hematopoietic prostaglandin D synthase Rattus norvegicus 97-122 7505994-1 1993 Reduced indocyanine green (ICG) uptake is one of the functional changes of human hepatocellular carcinoma (HCC). Indocyanine Green 8-25 HCC Homo sapiens 81-111 7505994-1 1993 Reduced indocyanine green (ICG) uptake is one of the functional changes of human hepatocellular carcinoma (HCC). Indocyanine Green 27-30 HCC Homo sapiens 81-111 7505994-2 1993 To clarify the mechanisms of loss of ICG uptake, and determine which subunit of glutathione-S-transferase (GST), alpha or pi, plays a role in ICG transport in hepatocytes, an experimental HCC model was developed that used nodules induced by 2-acetylamino-fluorene (2-AAF) administration. Indocyanine Green 142-145 hematopoietic prostaglandin D synthase Rattus norvegicus 80-105 7505994-2 1993 To clarify the mechanisms of loss of ICG uptake, and determine which subunit of glutathione-S-transferase (GST), alpha or pi, plays a role in ICG transport in hepatocytes, an experimental HCC model was developed that used nodules induced by 2-acetylamino-fluorene (2-AAF) administration. Indocyanine Green 142-145 hematopoietic prostaglandin D synthase Rattus norvegicus 107-110 7505994-3 1993 Many of the ICG stained nodules, which consisted of benign and borderline lesions, were GST-alpha positive. Indocyanine Green 12-15 hematopoietic prostaglandin D synthase Rattus norvegicus 88-91 7505994-4 1993 However, the percentage of GST-alpha positive cells tended to decrease according to the disappearance of ICG staining in the process of hepatocarcinogenesis. Indocyanine Green 105-108 hematopoietic prostaglandin D synthase Rattus norvegicus 27-30 7505994-8 1993 These results suggest that GST-alpha synthesis is disturbed in the process of hepatocarcinogenesis and results in loss of ICG uptake in HCCs, and also indicate that GST-pi may be useful for early diagnosis of preneoplastic hepatocytes showing no roles in ICG transport. Indocyanine Green 122-125 hematopoietic prostaglandin D synthase Rattus norvegicus 27-30 7505994-8 1993 These results suggest that GST-alpha synthesis is disturbed in the process of hepatocarcinogenesis and results in loss of ICG uptake in HCCs, and also indicate that GST-pi may be useful for early diagnosis of preneoplastic hepatocytes showing no roles in ICG transport. Indocyanine Green 255-258 hematopoietic prostaglandin D synthase Rattus norvegicus 27-30 7505994-8 1993 These results suggest that GST-alpha synthesis is disturbed in the process of hepatocarcinogenesis and results in loss of ICG uptake in HCCs, and also indicate that GST-pi may be useful for early diagnosis of preneoplastic hepatocytes showing no roles in ICG transport. Indocyanine Green 255-258 hematopoietic prostaglandin D synthase Rattus norvegicus 165-168 8334816-11 1993 The simulations using the new model indicate that the percentage of binding of Indocyanine Green to its transport protein (glutathione S-transferase) for removal in the bile will affect the estimation of the hepatic extraction ratio of Indocyanine Green. Indocyanine Green 236-253 microsomal glutathione S-transferase 1 Sus scrofa 123-148 8222999-2 1993 The relationship between ICG retention rate with serum albumin level and the incidence of ascites was investigated no significant change the rate was noted before and after. Indocyanine Green 25-28 albumin Homo sapiens 55-62 1768562-6 1991 During 150 min infusions of ICG (1.0 mg min-1) steady-state was reached within about 30 min and thereafter the plasma dye concentration remained essentially constant until the end of infusion. Indocyanine Green 28-31 CD59 molecule (CD59 blood group) Homo sapiens 40-45 1571496-4 1992 Vasopressin infusion significantly decreased intrinsic clearance of indocyanine green (-23%, P less than 0.01). Indocyanine Green 68-85 arginine vasopressin Homo sapiens 0-11 1571497-4 1992 Among the three parameters obtained by model analysis, k12 values more prominently differed among diseases and correlated well with blood tests such as total bilirubin, total bile acids, or 15 min retention of ICG. Indocyanine Green 210-213 keratin 12 Homo sapiens 55-58 1614390-6 1992 The peak value of FE BMG was significantly (p less than 0.01) lower in 5 patients with ICG 15" greater than 25% than in 21 patients with ICG 15" less than 20%. Indocyanine Green 87-90 beta-2-microglobulin Homo sapiens 21-24 1614390-6 1992 The peak value of FE BMG was significantly (p less than 0.01) lower in 5 patients with ICG 15" greater than 25% than in 21 patients with ICG 15" less than 20%. Indocyanine Green 137-140 beta-2-microglobulin Homo sapiens 21-24 1540213-8 1992 Indocyanine green, a non-substrate inhibitor of glutathione S-transferase, inhibited GTN metabolism by smooth muscle cells. Indocyanine Green 0-17 glutathione S-transferase kappa 1 Homo sapiens 48-73 1376785-2 1992 Net regional endothelin-1 balance was calculated from the respective arteriovenous differences in plasma concentrations and the corresponding plasma flow, the latter being determined by para-aminohippurate or indocyanine-green dye using appropriate catheter techniques. Indocyanine Green 209-226 endothelin 1 Homo sapiens 13-25 1768562-8 1991 Blood clearance (CLb) of ICG (15.9 +/- 2.2 ml min-1 kg-1; mean +/- s.d. Indocyanine Green 25-28 citramalyl-CoA lyase Homo sapiens 17-20 1768562-8 1991 Blood clearance (CLb) of ICG (15.9 +/- 2.2 ml min-1 kg-1; mean +/- s.d. Indocyanine Green 25-28 CD59 molecule (CD59 blood group) Homo sapiens 46-51 1768562-11 1991 The pharmacokinetics of ICG were shown to be linear up to plasma concentrations of at least 3 micrograms ml-1 using variable infusion rates (0.5, 1.0 and 2.0 mg min-1). Indocyanine Green 24-27 CD59 molecule (CD59 blood group) Homo sapiens 161-166 1859019-9 1991 Indocyanine green clearance was better preserved during sevoflurane anesthesia (39.7 +/- 12.0 ml.min-1) than during halothane anesthesia (30.9 +/- 8.4 ml.min-1; P less than 0.05). Indocyanine Green 0-17 CD59 molecule (CD59 blood group) Homo sapiens 97-102 1777376-6 1991 The addition of nisoldipine was also associated with significant changes in apparent liver blood flow (measured by indocyanine green clearance) from 1.4 to 2.4 l min-1 in the atenolol group and from 1.3 to 2.3 l min-1 in the propranolol group. Indocyanine Green 115-132 CD59 molecule (CD59 blood group) Homo sapiens 162-167 1798061-2 1991 The blood clearances of 99mTc-P and ICG in dogs decreased with increase in doses of CCl4 and with elapsed time after CCl4 administration. Indocyanine Green 36-39 C-C motif chemokine 4 Canis lupus familiaris 84-88 1798061-2 1991 The blood clearances of 99mTc-P and ICG in dogs decreased with increase in doses of CCl4 and with elapsed time after CCl4 administration. Indocyanine Green 36-39 C-C motif chemokine 4 Canis lupus familiaris 117-121 1859019-9 1991 Indocyanine green clearance was better preserved during sevoflurane anesthesia (39.7 +/- 12.0 ml.min-1) than during halothane anesthesia (30.9 +/- 8.4 ml.min-1; P less than 0.05). Indocyanine Green 0-17 CD59 molecule (CD59 blood group) Homo sapiens 154-159 8151095-5 1993 Vasopressin decreased both hepatic blood flow (-34%, P < 0.01) and intrinsic clearance of indocyanine green (-22%, P < 0.05). Indocyanine Green 93-110 arginine vasopressin Homo sapiens 0-11 2062015-6 1991 Plasma renin activity (PRA) and plasma concentration of aldosterone (PAC), angiotensin II (ANG II) and arginine vasopressin (AVP) were elevated in response to the reduction in ICG ratio by both diuretics. Indocyanine Green 176-179 renin Homo sapiens 7-12 2062015-6 1991 Plasma renin activity (PRA) and plasma concentration of aldosterone (PAC), angiotensin II (ANG II) and arginine vasopressin (AVP) were elevated in response to the reduction in ICG ratio by both diuretics. Indocyanine Green 176-179 angiotensinogen Homo sapiens 75-89 2062015-6 1991 Plasma renin activity (PRA) and plasma concentration of aldosterone (PAC), angiotensin II (ANG II) and arginine vasopressin (AVP) were elevated in response to the reduction in ICG ratio by both diuretics. Indocyanine Green 176-179 angiotensinogen Homo sapiens 91-97 2062015-6 1991 Plasma renin activity (PRA) and plasma concentration of aldosterone (PAC), angiotensin II (ANG II) and arginine vasopressin (AVP) were elevated in response to the reduction in ICG ratio by both diuretics. Indocyanine Green 176-179 arginine vasopressin Homo sapiens 112-123 33763353-0 2021 Human Serum Albumin Decorated Indocyanine Green Improves Fluorescence-Guided Resection of Residual Lesions of Breast Cancer in Mice. Indocyanine Green 30-47 albumin Mus musculus 6-19 33763353-3 2021 We envisioned that intraoperative real-time fluorescence imaging with a human serum albumin decorated indocyanine green probe could enable complete surgical removal of breast cancer in a mouse model. Indocyanine Green 102-119 albumin Homo sapiens 78-91 33763353-4 2021 Methods: We prepared the probe by conjugating indocyanine green (ICG) with human serum albumin (HSA). Indocyanine Green 46-63 albumin Homo sapiens 81-94 33763353-4 2021 Methods: We prepared the probe by conjugating indocyanine green (ICG) with human serum albumin (HSA). Indocyanine Green 65-68 albumin Homo sapiens 81-94 33824047-0 2021 Focused Ultrasound-Augmented Cancer Phototheranostics Using Albumin-Indocyanine Green Nanoparticles. Indocyanine Green 68-85 albumin Mus musculus 60-67 34823812-2 2022 Herein, based on the discovery of unique cisplatin-hydrazide and cisplatin-indocyanine green (ICG) coordination reactions, a multifunctional coordination nanoprodrug, cisplatin/ICG co-loaded hydrazided hyaluronan/bovine serum albumin (HBCI) nanoparticles, was developed by a desolvation-dual coordination process. Indocyanine Green 75-92 albumin Homo sapiens 220-233 16139020-0 2005 Indocyanine green angiography of juvenile X-linked retinoschisis. Indocyanine Green 0-17 retinoschisin 1 Homo sapiens 42-64 16139020-2 2005 However, indocyanine green (ICG) angiography features in eyes that are affected with XLRS were not yet described. Indocyanine Green 9-26 retinoschisin 1 Homo sapiens 85-89 16139020-2 2005 However, indocyanine green (ICG) angiography features in eyes that are affected with XLRS were not yet described. Indocyanine Green 28-31 retinoschisin 1 Homo sapiens 85-89 34752986-0 2022 CD44-targeted, indocyanine green-paclitaxel-loaded human serum albumin nanoparticles for potential image-guided drug delivery. Indocyanine Green 15-32 albumin Homo sapiens 57-70 34752986-2 2022 In this study we evaluated the potential of an indocyanine green (ICG) and paclitaxel (PTX) loaded human serum albumin (HSA) nanoparticles that was conjugated with hyaluronic acid for use in image-guided drug delivery targeted to CD44-positive non-small cell lung cancer (NSCLC). Indocyanine Green 47-64 CD44 molecule (Indian blood group) Homo sapiens 230-234 34757733-5 2021 On the other hand, an anti-programmed cell death 1 ligand 1 antibody (anti-PD-L1)-modified SA nanogel loaded with indocyanine green (ICG@SA-anti-PD-L1 nanogel) was prepared for diagnosing and inhibiting lung metastasis by assisting orthotopic tumor therapy. Indocyanine Green 114-131 CD274 molecule Homo sapiens 27-59 34967289-5 2022 METHODS: A novel biocompatible nanoparticle (HIT-NPs) was self-assembled through the intrinsic interaction between D-alpha-tocopherol Succinate (TOS), human serum albumin (HSA) and indocyanine green (ICG). Indocyanine Green 181-198 albumin Homo sapiens 157-170 34967289-5 2022 METHODS: A novel biocompatible nanoparticle (HIT-NPs) was self-assembled through the intrinsic interaction between D-alpha-tocopherol Succinate (TOS), human serum albumin (HSA) and indocyanine green (ICG). Indocyanine Green 200-203 albumin Homo sapiens 157-170 34977210-4 2021 ICG-001 is a small molecule inhibitor of Wnt/beta-catenin pathway. Indocyanine Green 0-3 catenin beta 1 Canis lupus familiaris 45-57 34757733-5 2021 On the other hand, an anti-programmed cell death 1 ligand 1 antibody (anti-PD-L1)-modified SA nanogel loaded with indocyanine green (ICG@SA-anti-PD-L1 nanogel) was prepared for diagnosing and inhibiting lung metastasis by assisting orthotopic tumor therapy. Indocyanine Green 114-131 CD274 molecule Homo sapiens 75-80 34757733-5 2021 On the other hand, an anti-programmed cell death 1 ligand 1 antibody (anti-PD-L1)-modified SA nanogel loaded with indocyanine green (ICG@SA-anti-PD-L1 nanogel) was prepared for diagnosing and inhibiting lung metastasis by assisting orthotopic tumor therapy. Indocyanine Green 114-131 CD274 molecule Homo sapiens 145-150 34757733-5 2021 On the other hand, an anti-programmed cell death 1 ligand 1 antibody (anti-PD-L1)-modified SA nanogel loaded with indocyanine green (ICG@SA-anti-PD-L1 nanogel) was prepared for diagnosing and inhibiting lung metastasis by assisting orthotopic tumor therapy. Indocyanine Green 133-136 CD274 molecule Homo sapiens 27-59 34757733-5 2021 On the other hand, an anti-programmed cell death 1 ligand 1 antibody (anti-PD-L1)-modified SA nanogel loaded with indocyanine green (ICG@SA-anti-PD-L1 nanogel) was prepared for diagnosing and inhibiting lung metastasis by assisting orthotopic tumor therapy. Indocyanine Green 133-136 CD274 molecule Homo sapiens 75-80 34757733-5 2021 On the other hand, an anti-programmed cell death 1 ligand 1 antibody (anti-PD-L1)-modified SA nanogel loaded with indocyanine green (ICG@SA-anti-PD-L1 nanogel) was prepared for diagnosing and inhibiting lung metastasis by assisting orthotopic tumor therapy. Indocyanine Green 133-136 CD274 molecule Homo sapiens 145-150 34900688-3 2021 ICG-001 is a small molecule inhibitor of Wnt/beta-catenin pathway. Indocyanine Green 0-3 catenin beta 1 Homo sapiens 45-57 34902616-13 2022 Herein, we developed a nano-vesicle system IA-PEP to integrate photosensitizer PEGylated indocyanine green and L-Arg with high loading content and to produce a ternary synergistic treatment combining NO therapy, photodynamic therapy (PDT) along with mild-temperature photothermal therapy (MPTT) under 808 nm laser irradiation. Indocyanine Green 89-106 prolyl endopeptidase Mus musculus 46-49 34900688-5 2021 The results showed that AF and ICG-001 synergistically depressed the growth and invasion of human colon cancer cells by inhibiting the phosphorylation of Signal Transducer and Activator of Transcription 3 (STAT3) and its downstream mediator B-cell lymphoma-2-like 1 (Bcl-xL) and inducing caspase-3-dependent apoptosis. Indocyanine Green 31-34 caspase 3 Homo sapiens 288-297 34427049-3 2021 ASP5354 (TK-1) is a novel indocyanine green derivative. Indocyanine Green 26-43 thymidine kinase 1 Homo sapiens 9-13 34900688-5 2021 The results showed that AF and ICG-001 synergistically depressed the growth and invasion of human colon cancer cells by inhibiting the phosphorylation of Signal Transducer and Activator of Transcription 3 (STAT3) and its downstream mediator B-cell lymphoma-2-like 1 (Bcl-xL) and inducing caspase-3-dependent apoptosis. Indocyanine Green 31-34 BCL2 like 1 Homo sapiens 267-273 34900688-5 2021 The results showed that AF and ICG-001 synergistically depressed the growth and invasion of human colon cancer cells by inhibiting the phosphorylation of Signal Transducer and Activator of Transcription 3 (STAT3) and its downstream mediator B-cell lymphoma-2-like 1 (Bcl-xL) and inducing caspase-3-dependent apoptosis. Indocyanine Green 31-34 signal transducer and activator of transcription 3 Homo sapiens 154-204 34900688-5 2021 The results showed that AF and ICG-001 synergistically depressed the growth and invasion of human colon cancer cells by inhibiting the phosphorylation of Signal Transducer and Activator of Transcription 3 (STAT3) and its downstream mediator B-cell lymphoma-2-like 1 (Bcl-xL) and inducing caspase-3-dependent apoptosis. Indocyanine Green 31-34 signal transducer and activator of transcription 3 Homo sapiens 206-211 34794446-3 2021 RESULTS: In this study, we described a hydrogen peroxide (H2O2) responsive manganese dioxide mineralized albumin nanocomposite loading with mitochondria function inhibitor phenformin (PM) and near-infrared photothermal dye indocyanine green (ICG) by modified two-step biomineralization method. Indocyanine Green 223-240 albumin Homo sapiens 105-112 34880776-7 2021 The hepatic elimination of ICG is affected by physiological factors such as hepatic blood flow or binding of ICG to plasma proteins, anthropometric factors such as body weight, age, and sex, or the protein amount of the organic anion-transporting polypeptide 1B3 (OATP1B3) mediating the hepatic uptake of ICG. Indocyanine Green 27-30 solute carrier organic anion transporter family member 1B3 Homo sapiens 220-262 34880776-7 2021 The hepatic elimination of ICG is affected by physiological factors such as hepatic blood flow or binding of ICG to plasma proteins, anthropometric factors such as body weight, age, and sex, or the protein amount of the organic anion-transporting polypeptide 1B3 (OATP1B3) mediating the hepatic uptake of ICG. Indocyanine Green 27-30 solute carrier organic anion transporter family member 1B3 Homo sapiens 264-271 34880776-7 2021 The hepatic elimination of ICG is affected by physiological factors such as hepatic blood flow or binding of ICG to plasma proteins, anthropometric factors such as body weight, age, and sex, or the protein amount of the organic anion-transporting polypeptide 1B3 (OATP1B3) mediating the hepatic uptake of ICG. Indocyanine Green 305-308 solute carrier organic anion transporter family member 1B3 Homo sapiens 220-262 34880776-7 2021 The hepatic elimination of ICG is affected by physiological factors such as hepatic blood flow or binding of ICG to plasma proteins, anthropometric factors such as body weight, age, and sex, or the protein amount of the organic anion-transporting polypeptide 1B3 (OATP1B3) mediating the hepatic uptake of ICG. Indocyanine Green 305-308 solute carrier organic anion transporter family member 1B3 Homo sapiens 264-271 34794446-3 2021 RESULTS: In this study, we described a hydrogen peroxide (H2O2) responsive manganese dioxide mineralized albumin nanocomposite loading with mitochondria function inhibitor phenformin (PM) and near-infrared photothermal dye indocyanine green (ICG) by modified two-step biomineralization method. Indocyanine Green 242-245 albumin Homo sapiens 105-112 34794446-4 2021 In combination with ICG induced mild-PTT and PM mediated mitochondria dysfunction, PD-L1 expression was obviously down-regulated and the generated immunological responses was able to effectively attack the remaining tumor cells. Indocyanine Green 20-23 CD274 molecule Homo sapiens 83-88 34606937-5 2021 The GOx can consume glucose, reduce ATP levels, and down-regulate the expression of heat shock proteins, which consequently sensitize tumor cells to indocyanine green-based photothermal therapy. Indocyanine Green 149-166 hydroxyacid oxidase 1 Homo sapiens 4-7 34802438-2 2021 In the present work, MMPs-degradable gelatin nanoparticles (GNPs) are simultaneously loaded with photosensitizer indocyanine green (ICG) along with signal transducer activator of transcription 3 (STAT3) inhibitor NSC74859 (NSC, N) for efficient photothermal therapy (PTT) and immunotherapy of HNSCCs. Indocyanine Green 113-130 matrix metallopeptidase 2 Mus musculus 21-25 34679571-3 2021 This method is based on the painless injection of the lymphatic-specific near-infrared fluorescent tracer indocyanine green complexed with human serum albumin, using MicronJet600TM microneedles, and monitoring the disappearance of the fluorescence signal at the injection site over time using a portable detection device named LymphMeter. Indocyanine Green 106-123 albumin Homo sapiens 145-158 34589145-3 2021 Vascular endothelial growth factor (VEGF) was used as the tumor-targeting protein to synthesize a multifunctional core-shell nanostructure, Au@SiO2-drug/VEGF, in which the drug can be indocyanine green (ICG; as an optical tracer) or doxorubicin (DOX; as a chemotherapeutic agent). Indocyanine Green 184-201 vascular endothelial growth factor A Homo sapiens 0-34 34589145-3 2021 Vascular endothelial growth factor (VEGF) was used as the tumor-targeting protein to synthesize a multifunctional core-shell nanostructure, Au@SiO2-drug/VEGF, in which the drug can be indocyanine green (ICG; as an optical tracer) or doxorubicin (DOX; as a chemotherapeutic agent). Indocyanine Green 184-201 vascular endothelial growth factor A Homo sapiens 36-40 34589145-3 2021 Vascular endothelial growth factor (VEGF) was used as the tumor-targeting protein to synthesize a multifunctional core-shell nanostructure, Au@SiO2-drug/VEGF, in which the drug can be indocyanine green (ICG; as an optical tracer) or doxorubicin (DOX; as a chemotherapeutic agent). Indocyanine Green 184-201 vascular endothelial growth factor A Homo sapiens 153-157 34589145-3 2021 Vascular endothelial growth factor (VEGF) was used as the tumor-targeting protein to synthesize a multifunctional core-shell nanostructure, Au@SiO2-drug/VEGF, in which the drug can be indocyanine green (ICG; as an optical tracer) or doxorubicin (DOX; as a chemotherapeutic agent). Indocyanine Green 203-206 vascular endothelial growth factor A Homo sapiens 0-34 34589145-3 2021 Vascular endothelial growth factor (VEGF) was used as the tumor-targeting protein to synthesize a multifunctional core-shell nanostructure, Au@SiO2-drug/VEGF, in which the drug can be indocyanine green (ICG; as an optical tracer) or doxorubicin (DOX; as a chemotherapeutic agent). Indocyanine Green 203-206 vascular endothelial growth factor A Homo sapiens 36-40 34589145-3 2021 Vascular endothelial growth factor (VEGF) was used as the tumor-targeting protein to synthesize a multifunctional core-shell nanostructure, Au@SiO2-drug/VEGF, in which the drug can be indocyanine green (ICG; as an optical tracer) or doxorubicin (DOX; as a chemotherapeutic agent). Indocyanine Green 203-206 vascular endothelial growth factor A Homo sapiens 153-157 34358695-4 2021 Accordingly, we developed a P-selectin-specific, photothermal theranostic nanocomposite for thrombus-targeted codelivery of Uk and indocyanine green (ICG, a contrast agent for near-infrared (NIR) fluorescence imaging). Indocyanine Green 131-148 selectin P Homo sapiens 28-38 34358695-4 2021 Accordingly, we developed a P-selectin-specific, photothermal theranostic nanocomposite for thrombus-targeted codelivery of Uk and indocyanine green (ICG, a contrast agent for near-infrared (NIR) fluorescence imaging). Indocyanine Green 150-153 selectin P Homo sapiens 28-38 34358695-13 2021 STATEMENT OF SIGNIFICANCE: : Herein, for the first time, a P-selectin specific, photothermal theranostic nanocomposite for thrombus-targeted co-delivery of urokinase and NIR fluorescence contrast agent indocyanine green (ICG) was developed. Indocyanine Green 202-219 selectin P Homo sapiens 59-69 34358695-13 2021 STATEMENT OF SIGNIFICANCE: : Herein, for the first time, a P-selectin specific, photothermal theranostic nanocomposite for thrombus-targeted co-delivery of urokinase and NIR fluorescence contrast agent indocyanine green (ICG) was developed. Indocyanine Green 221-224 selectin P Homo sapiens 59-69 34579526-4 2021 The antitumor drug celastrol (CLT) and the photosensitizer indocyanine green (ICG) are then loaded in it to form CIPP. Indocyanine Green 59-76 PATJ, crumbs cell polarity complex component Mus musculus 113-117 34579526-4 2021 The antitumor drug celastrol (CLT) and the photosensitizer indocyanine green (ICG) are then loaded in it to form CIPP. Indocyanine Green 78-81 PATJ, crumbs cell polarity complex component Mus musculus 113-117 34611093-0 2022 The Impact of Indocyanine Green Angiography on Fat Necrosis in Deep Inferior Epigastric Perforator Flap Breast Reconstruction. Indocyanine Green 14-31 FAT atypical cadherin 1 Homo sapiens 47-50 34414658-12 2021 CB2-activated mitochondrial dysfunction and cellular senescence could be blocked by ICG-001, a blocker for beta-catenin signalling. Indocyanine Green 84-87 cannabinoid receptor 2 Homo sapiens 0-3 34475406-2 2021 Inspired by this biochemical pathway, we demonstrate the reactive oxygen species (ROS) induced tumor therapy by integrating lactate oxidase (LOx) and catalase (CAT) into Fe3O4 nanoparticle/indocyanine green (ICG) co-loaded hybrid nanogels (designated as FIGs-LC). Indocyanine Green 189-206 lysyl oxidase Homo sapiens 141-144 34475406-2 2021 Inspired by this biochemical pathway, we demonstrate the reactive oxygen species (ROS) induced tumor therapy by integrating lactate oxidase (LOx) and catalase (CAT) into Fe3O4 nanoparticle/indocyanine green (ICG) co-loaded hybrid nanogels (designated as FIGs-LC). Indocyanine Green 189-206 catalase Homo sapiens 150-158 34475406-2 2021 Inspired by this biochemical pathway, we demonstrate the reactive oxygen species (ROS) induced tumor therapy by integrating lactate oxidase (LOx) and catalase (CAT) into Fe3O4 nanoparticle/indocyanine green (ICG) co-loaded hybrid nanogels (designated as FIGs-LC). Indocyanine Green 189-206 catalase Homo sapiens 160-163 34448393-6 2021 In this study, we developed a novel tumor-selective fluorescent agent by chemically linking ICG to mouse monoclonal antibody 10D7 that specifically recognizes an ovarian cancer-enriched cell surface receptor, CUB-domain-containing protein 1 (CDCP1). Indocyanine Green 92-95 CUB domain containing protein 1 Homo sapiens 209-240 34448393-6 2021 In this study, we developed a novel tumor-selective fluorescent agent by chemically linking ICG to mouse monoclonal antibody 10D7 that specifically recognizes an ovarian cancer-enriched cell surface receptor, CUB-domain-containing protein 1 (CDCP1). Indocyanine Green 92-95 CUB domain containing protein 1 Homo sapiens 242-247 34414658-12 2021 CB2-activated mitochondrial dysfunction and cellular senescence could be blocked by ICG-001, a blocker for beta-catenin signalling. Indocyanine Green 84-87 catenin beta 1 Homo sapiens 107-119 34374294-9 2021 Moreover, LiCl or ICG-001 exposure counteracted the effects of AHNAK2 silencing or upregulation on malignant phenotypes of TC cells. Indocyanine Green 18-21 AHNAK nucleoprotein 2 Homo sapiens 63-69 34477752-7 2021 Besides, the effect of ICG@Lip mediated PDT was significantly amplified by PMP@Alb nanoparticles. Indocyanine Green 23-26 albumin Homo sapiens 75-82 34214613-9 2021 Moreover, mechanistic study demonstrated that ICG-001 increased the radiation-induced DDR of HCC cells by suppressing p53, thus leading to stronger activation of cGAS/STING pathway. Indocyanine Green 46-49 transformation related protein 53, pseudogene Mus musculus 118-121 34407298-1 2022 PURPOSE: To compare the 12 months visual and anatomical outcomes of treatment-naive neovascular age-related macular degeneration (nAMD) patients diagnosed by optical coherence tomography angiography (OCT-A) compared with fluorescein angiography (FA)/indocyanine green angiography (ICGA), after anti-VEGF treatment in a real-world setting. Indocyanine Green 250-267 vascular endothelial growth factor A Homo sapiens 299-303 34445497-4 2021 We previously reported that the organic anion transporting polypeptide (OATP) 1B3 has an uptake capability for both MR agents (Gd-EOB-DTPA) and indocyanine green (ICG), a clinically available near-infrared (NIR) fluorescent dye. Indocyanine Green 144-161 solute carrier organic anion transporter family member 1B3 Homo sapiens 32-81 34445497-4 2021 We previously reported that the organic anion transporting polypeptide (OATP) 1B3 has an uptake capability for both MR agents (Gd-EOB-DTPA) and indocyanine green (ICG), a clinically available near-infrared (NIR) fluorescent dye. Indocyanine Green 163-166 solute carrier organic anion transporter family member 1B3 Homo sapiens 32-81 34445497-8 2021 Lastly, we validated the ICG uptake capability of both OATP1B1 and OATP1B3. Indocyanine Green 25-28 solute carrier organic anion transporter family member 1B1 Homo sapiens 55-62 34445497-8 2021 Lastly, we validated the ICG uptake capability of both OATP1B1 and OATP1B3. Indocyanine Green 25-28 solute carrier organic anion transporter family member 1B3 Homo sapiens 67-74 34361080-4 2021 PIT was conducted with an indocyanine green-labeled anti-HER2 antibody and an 808 nm laser irradiation. Indocyanine Green 26-43 erb-b2 receptor tyrosine kinase 2 Mus musculus 57-61 34387576-11 2022 CONCLUSIONS: There are 1 or more collecting lymph vessels in the posterior thigh by midlateral thigh ICG injection, which can be addressed for posterior thigh lymphedema. Indocyanine Green 101-104 VPS52 subunit of GARP complex Homo sapiens 19-24 34342216-5 2021 In vitro cell experiments confirmed that glucose-attached particles significantly promoted cellular uptake and increased intracellular ICG and Ca2+ concentrations by glucose transporter 1 (GLUT1)-mediated endocytosis. Indocyanine Green 135-138 solute carrier family 2 member 1 Homo sapiens 166-187 34342216-5 2021 In vitro cell experiments confirmed that glucose-attached particles significantly promoted cellular uptake and increased intracellular ICG and Ca2+ concentrations by glucose transporter 1 (GLUT1)-mediated endocytosis. Indocyanine Green 135-138 solute carrier family 2 member 1 Homo sapiens 189-194 34125528-4 2021 As the analogue of indocyanine green, dicarboxylic cypate is directly conjugated with the apoferritin molecules for forming assembly nanoprobes. Indocyanine Green 19-36 ferritin heavy chain 1 Homo sapiens 90-101 34262647-7 2021 ICG-Glu-Glu-AE105, consisting of the uPAR-targeting peptide AE105 conjugated to ICG, has shown great potential for fluorescence-guided surgery. Indocyanine Green 0-3 plasminogen activator, urokinase receptor Mus musculus 37-41 34430608-1 2021 Background: To investigate whether indocyanine green (ICG) fluorescence imaging can be used to evaluate chronic and acute liver injury induced by either a high-fat (HF) diet or carbon tetrachloride (CCl4). Indocyanine Green 35-52 C-C motif chemokine ligand 4 Rattus norvegicus 199-203 34430608-1 2021 Background: To investigate whether indocyanine green (ICG) fluorescence imaging can be used to evaluate chronic and acute liver injury induced by either a high-fat (HF) diet or carbon tetrachloride (CCl4). Indocyanine Green 54-57 C-C motif chemokine ligand 4 Rattus norvegicus 199-203 34060808-6 2021 In addition, NPs encapsulated with indocyanine green accumulated in cells overexpressing HER2 and exhibited superior photothermal treatment effects. Indocyanine Green 35-52 erb-b2 receptor tyrosine kinase 2 Homo sapiens 89-93 35616823-2 2022 Near-infrared (NIRF) fluorescence imaging is an emerging technology that permits detection of liver tumours after systemic injection of indocyanine green (ICG). Indocyanine Green 136-153 interleukin 17B Homo sapiens 15-19 35586908-5 2022 FA-EDTA/ICG-Lip NPs can release EDTA and ICG in lysosomes (pH 4.5) to reduce ECM production by down-regulating transforming growth factor beta (TGF-beta) and activating an immune response by inducing tumor cell immunogenic cell death (ICD), respectively. Indocyanine Green 41-44 tumor necrosis factor Homo sapiens 111-142 35586908-5 2022 FA-EDTA/ICG-Lip NPs can release EDTA and ICG in lysosomes (pH 4.5) to reduce ECM production by down-regulating transforming growth factor beta (TGF-beta) and activating an immune response by inducing tumor cell immunogenic cell death (ICD), respectively. Indocyanine Green 41-44 transforming growth factor alpha Homo sapiens 144-152 35616823-2 2022 Near-infrared (NIRF) fluorescence imaging is an emerging technology that permits detection of liver tumours after systemic injection of indocyanine green (ICG). Indocyanine Green 155-158 interleukin 17B Homo sapiens 15-19 35470688-1 2022 We herein report the synthesis of poly (9-decenoic acid-1-vinylimidazole-N-isopropylacrylamide) nanoparticles containing indocyanine green (ICG) in one pot and in water phase throughout the reaction. Indocyanine Green 121-138 mediator complex subunit 25 Homo sapiens 51-57 35164952-0 2022 Is the indocyanine green score an accurate predictor of postoperative parathyroid hormone level? Indocyanine Green 7-24 parathyroid hormone Homo sapiens 70-89 35164952-4 2022 We determined whether there is a correlation between intraoperative indocyanine green score and postoperative serum parathyroid hormone levels. Indocyanine Green 68-85 parathyroid hormone Homo sapiens 116-135 35164952-10 2022 There was a significant correlation between the global indocyanine green score and postoperative parathyroid hormone level. Indocyanine Green 55-72 parathyroid hormone Homo sapiens 97-116 35596202-0 2022 Monitoring of patients with rheumatoid arthritis by indocyanine green (ICG)-enhanced fluorescence optical imaging treated with anti-TNFalpha therapy. Indocyanine Green 52-69 tumor necrosis factor Homo sapiens 132-140 35596202-0 2022 Monitoring of patients with rheumatoid arthritis by indocyanine green (ICG)-enhanced fluorescence optical imaging treated with anti-TNFalpha therapy. Indocyanine Green 71-74 tumor necrosis factor Homo sapiens 132-140 35470688-1 2022 We herein report the synthesis of poly (9-decenoic acid-1-vinylimidazole-N-isopropylacrylamide) nanoparticles containing indocyanine green (ICG) in one pot and in water phase throughout the reaction. Indocyanine Green 140-143 mediator complex subunit 25 Homo sapiens 51-57 35217073-0 2022 Her3-specific affibody mediated tumor targeting delivery of ICG enhanced the photothermal therapy against Her3-positive tumors. Indocyanine Green 60-63 erb-b2 receptor tyrosine kinase 3 Homo sapiens 0-4 35470595-6 2022 A tumor-targeting nanomedicine is prepared by encapsulating indocyanine green into CD44 specifically binding material, a hyaluronic acid conjugated lipid poly(ethylene glycol). Indocyanine Green 60-77 CD44 molecule (Indian blood group) Homo sapiens 83-87 35217073-0 2022 Her3-specific affibody mediated tumor targeting delivery of ICG enhanced the photothermal therapy against Her3-positive tumors. Indocyanine Green 60-63 erb-b2 receptor tyrosine kinase 3 Homo sapiens 106-110 35381618-12 2022 CONCLUSIONS: ICG-001 and PRI-724 significantly ameliorated urethral fibrosis induced by transforming growth factor beta 1 in rats. Indocyanine Green 13-16 transforming growth factor, beta 1 Rattus norvegicus 88-121 34964404-6 2022 DPP3 associated with MELD-Na score, Child class, indocyanine green clearance, increased DPP3 with the increased hepatic venous pressure gradient (p = 0.015) as well as increased heart rate and reduced systemic vascular resistance. Indocyanine Green 49-66 dipeptidyl peptidase 3 Homo sapiens 0-4 35133042-3 2022 In this work, a biodegradable nanoplatform (termed as CSI) was fabricated by encapsulating catalase (CAT) into silica nanoparticles (CAT@SiO2 ) for tumor hypoxia relief, and then loaded with the sonosensitizer indocyanine green (ICG). Indocyanine Green 210-227 catalase Homo sapiens 91-99 35133042-3 2022 In this work, a biodegradable nanoplatform (termed as CSI) was fabricated by encapsulating catalase (CAT) into silica nanoparticles (CAT@SiO2 ) for tumor hypoxia relief, and then loaded with the sonosensitizer indocyanine green (ICG). Indocyanine Green 210-227 catalase Homo sapiens 101-104 35133042-3 2022 In this work, a biodegradable nanoplatform (termed as CSI) was fabricated by encapsulating catalase (CAT) into silica nanoparticles (CAT@SiO2 ) for tumor hypoxia relief, and then loaded with the sonosensitizer indocyanine green (ICG). Indocyanine Green 229-232 catalase Homo sapiens 91-99 35133042-3 2022 In this work, a biodegradable nanoplatform (termed as CSI) was fabricated by encapsulating catalase (CAT) into silica nanoparticles (CAT@SiO2 ) for tumor hypoxia relief, and then loaded with the sonosensitizer indocyanine green (ICG). Indocyanine Green 229-232 catalase Homo sapiens 101-104 35574516-5 2022 Results: We successfully prepared the ICG-beta-CD complex. Indocyanine Green 38-41 ACD, shelterin complex subunit and telomerase recruitment factor Rattus norvegicus 42-49 35574516-11 2022 Conclusions: ICG-beta-CD showed faster lymphatic transport than ICG, allowing for more rapid lymphatic NIR imaging. Indocyanine Green 13-16 ACD, shelterin complex subunit and telomerase recruitment factor Rattus norvegicus 17-24 35022636-5 2022 This study proposed a novel multifunctional nanosystem for the targeted delivery of indocyanine green (ICG), 2,2"-azobis(2-(2-imidazolinI-2-yl) propane) dihydrochloride (AIBI), and heat shock protein 90 (Hsp90) inhibitor geldanamycin (17-AAG). Indocyanine Green 103-106 heat shock protein 90 alpha family class A member 1 Homo sapiens 181-202 35022636-5 2022 This study proposed a novel multifunctional nanosystem for the targeted delivery of indocyanine green (ICG), 2,2"-azobis(2-(2-imidazolinI-2-yl) propane) dihydrochloride (AIBI), and heat shock protein 90 (Hsp90) inhibitor geldanamycin (17-AAG). Indocyanine Green 103-106 heat shock protein 90 alpha family class A member 1 Homo sapiens 204-209 35063460-6 2022 A specifically developed software named "IGNITE" (Indocyanine GreeN automatIc augmenTed rEality) allowed the automatic anchorage of the HA3D model to the real organ, leveraging the enhanced view offered by NIRF technology. Indocyanine Green 50-67 interleukin 17B Homo sapiens 207-211 35280253-5 2021 Near infrared-indocyanine green (NIR-ICG) lymphatic imaging system has shown that NG-R1 significantly improved the lymphatic drainage function. Indocyanine Green 14-31 reticulon 4 receptor Mus musculus 82-87 35198763-6 2022 ICG-001 increased beta-catenin binding to regions with both the TCF and AP-1 motifs, flanking the genes induced by ICG-001, concomitant with the increments of the p300 and AP-1 component c-JUN binding. Indocyanine Green 0-3 catenin beta 1 Homo sapiens 18-30 35198763-6 2022 ICG-001 increased beta-catenin binding to regions with both the TCF and AP-1 motifs, flanking the genes induced by ICG-001, concomitant with the increments of the p300 and AP-1 component c-JUN binding. Indocyanine Green 0-3 E1A binding protein p300 Homo sapiens 163-167 35198763-6 2022 ICG-001 increased beta-catenin binding to regions with both the TCF and AP-1 motifs, flanking the genes induced by ICG-001, concomitant with the increments of the p300 and AP-1 component c-JUN binding. Indocyanine Green 0-3 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 172-176 35198763-6 2022 ICG-001 increased beta-catenin binding to regions with both the TCF and AP-1 motifs, flanking the genes induced by ICG-001, concomitant with the increments of the p300 and AP-1 component c-JUN binding. Indocyanine Green 0-3 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 187-192 35198763-6 2022 ICG-001 increased beta-catenin binding to regions with both the TCF and AP-1 motifs, flanking the genes induced by ICG-001, concomitant with the increments of the p300 and AP-1 component c-JUN binding. Indocyanine Green 115-118 catenin beta 1 Homo sapiens 18-30 35198763-6 2022 ICG-001 increased beta-catenin binding to regions with both the TCF and AP-1 motifs, flanking the genes induced by ICG-001, concomitant with the increments of the p300 and AP-1 component c-JUN binding. Indocyanine Green 115-118 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 72-76 35198763-6 2022 ICG-001 increased beta-catenin binding to regions with both the TCF and AP-1 motifs, flanking the genes induced by ICG-001, concomitant with the increments of the p300 and AP-1 component c-JUN binding. Indocyanine Green 115-118 E1A binding protein p300 Homo sapiens 163-167 35198763-6 2022 ICG-001 increased beta-catenin binding to regions with both the TCF and AP-1 motifs, flanking the genes induced by ICG-001, concomitant with the increments of the p300 and AP-1 component c-JUN binding. Indocyanine Green 115-118 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 172-176 35198763-6 2022 ICG-001 increased beta-catenin binding to regions with both the TCF and AP-1 motifs, flanking the genes induced by ICG-001, concomitant with the increments of the p300 and AP-1 component c-JUN binding. Indocyanine Green 115-118 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 187-192 35198763-6 2022 ICG-001 increased beta-catenin binding to regions with both the TCF and AP-1 motifs, flanking the genes induced by ICG-001, concomitant with the increments of the p300 and AP-1 component c-JUN binding. Indocyanine Green 0-3 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 72-76 35108666-3 2022 METHODS: We developed a unique near-infrared (NIR) fluorescence imaging probe, ICG-p28, composed of the clinically nontoxic tumour-targeting peptide p28 and the FDA-approved NIR dye indocyanine green (ICG). Indocyanine Green 182-199 golgi SNAP receptor complex member 1 Homo sapiens 83-86 35591825-0 2022 Binding indocyanine green to human serum albumin potentially enhances the detection of sentinel lymph nodes. Indocyanine Green 8-25 albumin Homo sapiens 35-48 35047479-0 2021 Development and Validation of a Bioanalytical UHPLC-MS/MS Method Applied to Murine Liver Tissue for the Determination of Indocyanine Green Loaded in H-Ferritin Nanoparticles. Indocyanine Green 121-138 ferritin heavy polypeptide 1 Mus musculus 149-159 35224499-5 2022 Herein, an HCC targeted NIR-II fluorescent probe, GPC-ICG, was developed by labelling a humanized anti-GPC3 monoclonal antibody with indocyanine green (ICG). Indocyanine Green 133-150 glypican 3 Mus musculus 103-107 35224499-5 2022 Herein, an HCC targeted NIR-II fluorescent probe, GPC-ICG, was developed by labelling a humanized anti-GPC3 monoclonal antibody with indocyanine green (ICG). Indocyanine Green 152-155 glypican 3 Mus musculus 103-107 35094362-5 2022 The NIR imaging agent, ICG-p28, a water-soluble, nontoxic, and pan-tumor targeting probe consisting of a cell-penetrating peptide (p28) conjugated to indocyanine green (ICG), can accurately localize tumors in vivo. Indocyanine Green 150-167 golgi SNAP receptor complex member 1 Homo sapiens 27-30 35094362-5 2022 The NIR imaging agent, ICG-p28, a water-soluble, nontoxic, and pan-tumor targeting probe consisting of a cell-penetrating peptide (p28) conjugated to indocyanine green (ICG), can accurately localize tumors in vivo. Indocyanine Green 150-167 golgi SNAP receptor complex member 1 Homo sapiens 131-134 35094362-5 2022 The NIR imaging agent, ICG-p28, a water-soluble, nontoxic, and pan-tumor targeting probe consisting of a cell-penetrating peptide (p28) conjugated to indocyanine green (ICG), can accurately localize tumors in vivo. Indocyanine Green 169-172 golgi SNAP receptor complex member 1 Homo sapiens 27-30 35094362-5 2022 The NIR imaging agent, ICG-p28, a water-soluble, nontoxic, and pan-tumor targeting probe consisting of a cell-penetrating peptide (p28) conjugated to indocyanine green (ICG), can accurately localize tumors in vivo. Indocyanine Green 169-172 golgi SNAP receptor complex member 1 Homo sapiens 131-134 35591825-5 2022 Indocyanine green is characterized by its high affinity for human serum albumin (HSA). Indocyanine Green 0-17 albumin Homo sapiens 66-79 2537790-10 1989 In comparison with the high-lymphokine-activated killer group, the low-lymphokine-activated killer group showed a significant decrease in gamma-interferon production and a preserved function of indocyanine green clearance. Indocyanine Green 194-211 interleukin 2 Homo sapiens 71-81 2537715-5 1989 In liver diseases serum IGF-II showed a significant correlation with liver function test (negative with retention of indocyanine green and total bile acids; positive with albumin, thrombo-test, and cholinesterase). Indocyanine Green 117-134 insulin like growth factor 2 Homo sapiens 24-30 2623191-3 1989 The percent uptake of VIP after the higher bolus, as estimated by comparing the levels of VIP and ICG in the pulmonary artery and the aorta, was 36 +/- 6% during control infusion and 36 +/- 13% during continuous infusion of VIP (3 pmol.kg-1.min-1). Indocyanine Green 98-101 vasoactive intestinal peptide Sus scrofa 22-25 2772920-7 1989 The molar ratio of BCAA/AAA (MR) significantly correlated with ICG k, ICG R15, PT and the sum of blood ammonia in an oral ammonia tolerance test which may reflect the degree of hepatic disorder. Indocyanine Green 63-66 AT-rich interaction domain 4B Homo sapiens 19-23 2538260-2 1989 Significant differences in the survival patterns were noted when analysed on the basis of the preoperative indocyanine green maximal removal rate (greater than 0.4 mg kg-1 min-1 versus less than 0.4 mg kg-1 min-1), tumor size (greater than 5 cm versus less than 5 cm, etc.) Indocyanine Green 107-124 CD59 molecule (CD59 blood group) Homo sapiens 172-177 2608720-5 1989 Binding of CPM to the GSH S-transferase fraction was inhibited by both indocyanine green, which is known to bind liver GSH S-transferases intensively, and by cefoperazon, which is mainly excreted into the bile. Indocyanine Green 71-88 glutathione synthetase Mus musculus 22-27 2608720-5 1989 Binding of CPM to the GSH S-transferase fraction was inhibited by both indocyanine green, which is known to bind liver GSH S-transferases intensively, and by cefoperazon, which is mainly excreted into the bile. Indocyanine Green 71-88 glutathione synthetase Mus musculus 119-124 3510529-2 1986 Urinary kallikrein excretion in cirrhotics showed a positive correlation with serum albumin, indocyanine green disappearance rate, cholinesterase, and prothrombin, and an inverse correlation with bilirubin. Indocyanine Green 93-110 kallikrein related peptidase 4 Homo sapiens 8-18 3764923-2 1986 This compound, in a dose-dependent way, markedly reduced the increases in serum transaminase activities, the extent of liver cell necrosis, and the delay in indocyanine green (ICG) disappearance produced by a single toxic dosage of CCl4. Indocyanine Green 157-174 C-C motif chemokine ligand 4 Rattus norvegicus 232-236 3764923-2 1986 This compound, in a dose-dependent way, markedly reduced the increases in serum transaminase activities, the extent of liver cell necrosis, and the delay in indocyanine green (ICG) disappearance produced by a single toxic dosage of CCl4. Indocyanine Green 176-179 C-C motif chemokine ligand 4 Rattus norvegicus 232-236 3764923-5 1986 Furthermore, in the chronic liver injury induced by repeated administrations of CCl4 for 12 weeks, significant reductions of the increases in serum enzyme activities, liver fibrosis, and liver enlargement, and improvement in the ICG retention rate, were recognized in the Y-8845-treated groups at 10 mg/kg po or less. Indocyanine Green 229-232 C-C motif chemokine ligand 4 Rattus norvegicus 80-84 2941530-6 1986 Indocyanine green clearance, a measure of hepatic blood flow, was significantly decreased by a 2-h rANP infusion at 1.0 microgram/min. Indocyanine Green 0-17 natriuretic peptide A Rattus norvegicus 99-103 3147903-9 1988 The intrinsic hepatic clearance of ICG was on average 0.75 +/- 0.26 l plasma min-1 (+/- SD, n = 20) in controls and 0.39 +/- 0.18 l plasma min-1 in liver patients (n = 41), P less than 0.001. Indocyanine Green 35-38 CD59 molecule (CD59 blood group) Homo sapiens 77-82 4078997-11 1985 There was a close correlation between disappearance rate of indocyanine green (KICG) and parameters such as T1/2, K10, Clt and Cler with coefficients of -0.642, 0.723, 0.690 and 0.682, respectively. Indocyanine Green 60-77 keratin 10 Homo sapiens 114-117 4068375-4 1985 Gomisin A showed a tendency to prevent the delays of the disappearance of plasma ICG induced by CCl4, d-galactosamine and orotic acid, but not that by ANIT. Indocyanine Green 81-84 C-C motif chemokine ligand 4 Rattus norvegicus 96-100 2991101-4 1985 The retention rate of indocyanin green (ICGR15) was highly correlated with the plasma cyclic GMP level. Indocyanine Green 22-38 5'-nucleotidase, cytosolic II Homo sapiens 93-96 7234060-0 1981 [Activity of alanine aminotransferase and sorbitol dehydrogenase in rat serum following loading with indocyanine green]. Indocyanine Green 101-118 glutamic--pyruvic transaminase Homo sapiens 13-37 4013767-0 1985 Effect of oxytocin infusion during labor: indocyanin green elimination and serum bilirubin levels. Indocyanine Green 42-58 oxytocin/neurophysin I prepropeptide Homo sapiens 10-18 1188179-3 1975 The data suggest that although bilirubin, ICG and BSP bind to the intracellular hepatic transport protein ligandin one cannot achieve conditions in intact rats to demonstrate effects of competitive interaction with ligandin that affect plasma kinetics of these substances. Indocyanine Green 42-45 glutathione S-transferase alpha 2 Rattus norvegicus 106-114 670360-0 1978 Electrophoretic bimorphism of serum albumin in the presence of indocyanine green. Indocyanine Green 63-80 albumin Homo sapiens 30-43 1266541-2 1976 During vasopressin infusion the total hepatic blood flow, estimated by the Bradley technique with indocyanine green dye, was reduced to 61% of the value at rest. Indocyanine Green 98-115 arginine vasopressin Homo sapiens 7-18 4472039-0 1974 Competitive binding of bilirubin, sulfobromophthalein, indocyanine green and other organic anions to human and bovine serum albumin. Indocyanine Green 55-72 albumin Homo sapiens 118-131 124635-2 1975 When indicatior (e,g., indocyanine green) is injected centrally (right venticle or pulmonary artery) and blood is withdrawn rapidly from either the aorta or other central systemic artery, in the presence of a left-to-right shunt to recorded indicator-dilution curve usually shows two discrete peaks: p-1 of the magnitude of the shunt expressed as percent of pulmonary blood flow, Experimental and clinical data demonstrate that this method is accurate in quantitating shunts from such curves. Indocyanine Green 23-40 crystallin gamma F, pseudogene Homo sapiens 300-303 34019367-0 2021 Correction to "Indocyanine Green-holo-Transferrin Nanoassemblies for Tumor-Targeted Dual-Modal Imaging and Photothermal Therapy of Glioma". Indocyanine Green 15-32 transferrin Homo sapiens 38-49 33230583-3 2021 METHODS: In this double-arm retrospective study, we sought to establish the usefulness of indocyanine green as an alternative or an addition to the conventional Technetium99m (Tc99m) in the identification of the SLN in early breast cancer. Indocyanine Green 90-107 sarcolipin Homo sapiens 212-215 34045853-11 2021 Experiments by A375 melanoma cells and tumor-bearing mice demonstrated that the compound MSN(Mn)-ICG/DTIC have excellent biocompatibility and our combined therapy platform delivered a superior antitumor effect compared to standalone treatment in vivo and in vitro. Indocyanine Green 97-100 moesin Mus musculus 89-92 34033934-17 2021 Both biomarkers failed to maintain the reduction in both groups and significantly increased levels for IL-1beta was noted at 6 months follow up Conclusion: Multiple application of indocyanine-green mediated photodynamic therapy resulted in improved clinical and microbial parameters among type 2 DM subjects in the treatment of peri-implantitis. Indocyanine Green 180-197 interleukin 1 alpha Homo sapiens 103-111 33890892-5 2021 Indocyanine green angiography was applied to visualize flap vascularity and to analyze flap hemodynamics. Indocyanine Green 0-17 arachidonate 5-lipoxygenase activating protein Rattus norvegicus 55-59 32989784-3 2021 We aimed to develop a near-infrared fluorescent imaging technology for GIST targeting c-KIT using the novel fluorescent probe indocyanine green-labeled dasatinib (ICG-dasatinib) and to investigate the antitumor effect of ICG-dasatinib on GIST cells. Indocyanine Green 126-143 KIT proto-oncogene, receptor tyrosine kinase Homo sapiens 86-91 32989784-3 2021 We aimed to develop a near-infrared fluorescent imaging technology for GIST targeting c-KIT using the novel fluorescent probe indocyanine green-labeled dasatinib (ICG-dasatinib) and to investigate the antitumor effect of ICG-dasatinib on GIST cells. Indocyanine Green 163-166 KIT proto-oncogene, receptor tyrosine kinase Homo sapiens 86-91 33975609-9 2021 After endocytosis by MDA-MB-231 cells, Lipo/pB-DOX/ICG produced a large amount of ROS for PDT by laser irradiation, and pB-DOX was converted to DOX by ROS for chemotherapy. Indocyanine Green 51-54 high mobility group AT-hook 2 Homo sapiens 39-43 33975609-12 2021 Under irradiation at this time point, the tumors in Lipo/pB-DOX/ICG group almost disappeared with 94.9 % tumor growth inhibition, while those in the control groups were only partially inhibited. Indocyanine Green 64-67 high mobility group AT-hook 2 Homo sapiens 52-56 33975609-14 2021 CONCLUSIONS: Lipo/pB-DOX/ICG is a novel tool for on-demand drug release at tumor site and also a promising candidate for controllable and accurate combinatorial tumor therapy. Indocyanine Green 25-28 high mobility group AT-hook 2 Homo sapiens 13-17 33890892-5 2021 Indocyanine green angiography was applied to visualize flap vascularity and to analyze flap hemodynamics. Indocyanine Green 0-17 arachidonate 5-lipoxygenase activating protein Rattus norvegicus 87-91 33562574-4 2021 This nanosystem is constituted by 24 monomers of H-Ferritin (HFn), which self-assemble into a spherical cage structure enclosing the indocyanine green fluorescent tracer. Indocyanine Green 133-150 ferritin heavy polypeptide 1 Mus musculus 49-59 33877725-11 2021 Aspartate transaminase-to-platelet ratio index, fibrosis-4, hyaluronic acid, and the 15-minute indocyanine green retention rate were significantly correlated with M2BP mRNA expression. Indocyanine Green 95-112 galectin 3 binding protein Homo sapiens 163-167 31335230-0 2021 Indocyanine Green Angiography for Continuously Monitoring Blood Flow Changes and Predicting Perfusion of Deep Inferior Epigastric Perforator Flap in Rats. Indocyanine Green 0-17 arachidonate 5-lipoxygenase activating protein Rattus norvegicus 141-145 31335230-12 2021 Dynamic and continuous observation with ICG angiography through an SPY system is a powerful method for monitoring of blood supply in flaps that can be used to predict flap perfusion with a strong positive predictive significance. Indocyanine Green 40-43 arachidonate 5-lipoxygenase activating protein Rattus norvegicus 133-137 33759820-0 2021 Reply: Intraoperative Assessment of DIEP Flap Breast Reconstruction Using Indocyanine Green Angiography: Reduction of Fat Necrosis, Resection Volumes, and Postoperative Surveillance. Indocyanine Green 74-91 FAT atypical cadherin 1 Homo sapiens 118-121 33759823-0 2021 Intraoperative Assessment of DIEP Flap Breast Reconstruction Using Indocyanine Green Angiography: Reduction of Fat Necrosis, Resection Volumes, and Postoperative Surveillance. Indocyanine Green 67-84 FAT atypical cadherin 1 Homo sapiens 111-114 32596824-4 2021 STUDY DESIGN/MATERIALS AND METHODS: Briefly, MnO2 -ICG@BSA was prepared using a mild protein synthesis method by loading indocyanine green (ICG) into a bovine serum albumin-manganese dioxide complex (MnO2 @BSA); next, its characteristics were determined. Indocyanine Green 51-54 albumin Mus musculus 159-172 33723184-3 2021 To overcome the problems, we have performed real-time vessel navigation by using indocyanine green (ICG) fluorescence during lap-WT. Indocyanine Green 81-98 LAP Homo sapiens 125-128 33723184-3 2021 To overcome the problems, we have performed real-time vessel navigation by using indocyanine green (ICG) fluorescence during lap-WT. Indocyanine Green 100-103 LAP Homo sapiens 125-128 33723184-9 2021 Conclusion: We believe that laparoscopic real-time vessel navigation using indocyanine green fluorescence during lap-WT could contribute in reducing the post-operative spleen-related complications. Indocyanine Green 75-92 LAP Homo sapiens 28-31 33868396-3 2021 Photosensitizer indocyanine green (ICG) and chemotherapy drug Curcumin (CUR) were coencapsulated into the liposomes, followed by the surface conjugation of GE11 peptide for epidermal growth factor receptor (EGFR) targeting on the cancer cell surface. Indocyanine Green 16-33 epidermal growth factor receptor Homo sapiens 173-205 33868920-4 2021 A human serum albumin (HSA)-based nanoprobe modified with RGDfk peptide was constructed by encapsulating indocyanine green (ICG) via electrostatic force (ICG-HSA-RGDfk NPs, IHR-NPs). Indocyanine Green 105-122 albumin Homo sapiens 8-21 33562574-4 2021 This nanosystem is constituted by 24 monomers of H-Ferritin (HFn), which self-assemble into a spherical cage structure enclosing the indocyanine green fluorescent tracer. Indocyanine Green 133-150 ferritin heavy polypeptide 1 Mus musculus 61-64 33613250-4 2021 A 74-year-old Japanese man diagnosed with retinal angiomatous proliferation by fluorescein angiography and indocyanine green angiography was treated with intravitreal anti-VEGF injection. Indocyanine Green 107-124 vascular endothelial growth factor A Homo sapiens 172-176 33438958-0 2021 Compromised Flap Salvage With Closed Incision Negative Pressure Therapy Under Real-Time Indocyanine Green Fluorescence Assessment. Indocyanine Green 88-105 arachidonate 5-lipoxygenase activating protein Homo sapiens 12-16 33494469-1 2021 Indocyanine green near-infrared fluorescence (ICG-NIRF) imaging has recently come into use as a novel method in peri-operative microvascular flap assessment. Indocyanine Green 0-17 interleukin 17B Homo sapiens 50-54 33494469-1 2021 Indocyanine green near-infrared fluorescence (ICG-NIRF) imaging has recently come into use as a novel method in peri-operative microvascular flap assessment. Indocyanine Green 0-17 perilipin 1 Homo sapiens 112-116 33488079-2 2021 In this study, we have prepared and characterized a kind of novel ICG&Cur@MoS2 (ICG and Cur represent indocyanine green and curcumin, respectively) nanoplatform, which can achieve photothermal-photodynamic therapy and inhibit the P-gp effectively and safely. Indocyanine Green 102-119 ATP binding cassette subfamily B member 1 Homo sapiens 230-234 33373178-3 2021 Here, we develop a recycled cerium oxide (CeO2) catalase nanozyme-loaded hyaluronic acid nanovesicle to address the hypoxic tumor microenvironments and targeted delivery of the photosensitizers [indocyanine green (ICG)] to tumors. Indocyanine Green 195-212 catalase Homo sapiens 48-56 33373178-3 2021 Here, we develop a recycled cerium oxide (CeO2) catalase nanozyme-loaded hyaluronic acid nanovesicle to address the hypoxic tumor microenvironments and targeted delivery of the photosensitizers [indocyanine green (ICG)] to tumors. Indocyanine Green 214-217 catalase Homo sapiens 48-56 33532192-5 2021 Additionally, GNP-DOX/ICG showed a size reduction of the particles to 33.24 +- 4.11 nm and further improved drug release with the degradation of overexpressed MMP-2 in tumor. Indocyanine Green 22-25 matrix metallopeptidase 2 Homo sapiens 159-164 33380403-7 2020 In na?ve RAW264.7 cells, treatment with both ICG-001 and LPS, as compared with LPS alone, significant promoted TNF-alpha and IL-6 secretions, increased intracellular levels of TNF-alpha, IL-6 and iNOS (P < 0.05), and reduced intracellular FKN, Wnt-4 and beta-catenin levels (P < 0.01). Indocyanine Green 45-48 tumor necrosis factor Mus musculus 111-120 32875443-2 2021 This video aimed to present a novel laparoscopic ALR strategy of tumor-bearing portal territory hepatectomy with an indocyanine green (ICG) fluorescent dual staining technique. Indocyanine Green 116-133 growth factor, augmenter of liver regeneration Homo sapiens 49-52 32875443-2 2021 This video aimed to present a novel laparoscopic ALR strategy of tumor-bearing portal territory hepatectomy with an indocyanine green (ICG) fluorescent dual staining technique. Indocyanine Green 135-138 growth factor, augmenter of liver regeneration Homo sapiens 49-52 33380403-7 2020 In na?ve RAW264.7 cells, treatment with both ICG-001 and LPS, as compared with LPS alone, significant promoted TNF-alpha and IL-6 secretions, increased intracellular levels of TNF-alpha, IL-6 and iNOS (P < 0.05), and reduced intracellular FKN, Wnt-4 and beta-catenin levels (P < 0.01). Indocyanine Green 45-48 interleukin 6 Mus musculus 125-129 33380403-7 2020 In na?ve RAW264.7 cells, treatment with both ICG-001 and LPS, as compared with LPS alone, significant promoted TNF-alpha and IL-6 secretions, increased intracellular levels of TNF-alpha, IL-6 and iNOS (P < 0.05), and reduced intracellular FKN, Wnt-4 and beta-catenin levels (P < 0.01). Indocyanine Green 45-48 tumor necrosis factor Mus musculus 176-185 33380403-7 2020 In na?ve RAW264.7 cells, treatment with both ICG-001 and LPS, as compared with LPS alone, significant promoted TNF-alpha and IL-6 secretions, increased intracellular levels of TNF-alpha, IL-6 and iNOS (P < 0.05), and reduced intracellular FKN, Wnt-4 and beta-catenin levels (P < 0.01). Indocyanine Green 45-48 interleukin 6 Mus musculus 187-191 33380403-7 2020 In na?ve RAW264.7 cells, treatment with both ICG-001 and LPS, as compared with LPS alone, significant promoted TNF-alpha and IL-6 secretions, increased intracellular levels of TNF-alpha, IL-6 and iNOS (P < 0.05), and reduced intracellular FKN, Wnt-4 and beta-catenin levels (P < 0.01). Indocyanine Green 45-48 wingless-type MMTV integration site family, member 4 Mus musculus 244-249 33380403-7 2020 In na?ve RAW264.7 cells, treatment with both ICG-001 and LPS, as compared with LPS alone, significant promoted TNF-alpha and IL-6 secretions, increased intracellular levels of TNF-alpha, IL-6 and iNOS (P < 0.05), and reduced intracellular FKN, Wnt-4 and beta-catenin levels (P < 0.01). Indocyanine Green 45-48 catenin (cadherin associated protein), beta 1 Mus musculus 254-266 32253688-2 2020 Indocyanine green near-infrared fluoroangiography (NIRF/ICG) is a technique that allows for the assessment of intestinal perfusion before and after the formation of an anastomosis. Indocyanine Green 0-17 interleukin 17B Homo sapiens 51-55 33140761-3 2020 Herein, we constructed gas-generating mesoporous silica nanoparticles (MSNs) that can load ammonium bicarbonate (ABC) and doxorubicin (DOX) within the pores, encapsulate indocyanine green (ICG) onto the polydopamine (PDA) layer, and modify the RGD peptide on the outer surface [denoted as M(abc)-DOX@PDA-ICG-PEG-RGD] for triggered drug release and targeted chemophotothermal combination therapy. Indocyanine Green 170-187 gastrin Homo sapiens 23-26 33140761-3 2020 Herein, we constructed gas-generating mesoporous silica nanoparticles (MSNs) that can load ammonium bicarbonate (ABC) and doxorubicin (DOX) within the pores, encapsulate indocyanine green (ICG) onto the polydopamine (PDA) layer, and modify the RGD peptide on the outer surface [denoted as M(abc)-DOX@PDA-ICG-PEG-RGD] for triggered drug release and targeted chemophotothermal combination therapy. Indocyanine Green 189-192 gastrin Homo sapiens 23-26 33023995-8 2020 Inhibition of Wnt signaling via ICG-001 resulted in significantly decreased nasal polypoid lesions (p<0.001), EMT-related markers (p=0.019 for E-cadherin and p=0.002 for vimentin) and the mRNA levels of IL-4 (p<0.001) and IL-17A (p=0.004) compared with the positive control group. Indocyanine Green 32-35 Wnt family member 3A Homo sapiens 14-17 32898630-5 2020 In vitro studies showed that combination of laser assisted indocyanine green-mediated photothermal therapy and doxorubicin-mediated chemotherapy effectively eradicated cancer cells and resulted in the highest level of damage-associated molecular pattern presentation (calreticulin, high mobility group box 1, and adenosine triphosphate) compared to the individual treatments alone. Indocyanine Green 59-76 calreticulin Homo sapiens 268-280 32898630-5 2020 In vitro studies showed that combination of laser assisted indocyanine green-mediated photothermal therapy and doxorubicin-mediated chemotherapy effectively eradicated cancer cells and resulted in the highest level of damage-associated molecular pattern presentation (calreticulin, high mobility group box 1, and adenosine triphosphate) compared to the individual treatments alone. Indocyanine Green 59-76 high mobility group box 1 Homo sapiens 282-307 33103587-6 2021 We also found the WNT signaling pathway inhibitor ICG-001 can block HOXB13 gene-induced tumor metastasis, therefore ICG-001 may be a promising molecular intervention. Indocyanine Green 50-53 homeobox B13 Homo sapiens 68-74 32668181-5 2020 Intraoperative indocyanine green angiography was utilized for visualization of flap perfusion and analysis of the hemodynamics of pre-existing perforator and prefabricated vessels. Indocyanine Green 15-32 arachidonate 5-lipoxygenase activating protein Homo sapiens 79-83 33023995-8 2020 Inhibition of Wnt signaling via ICG-001 resulted in significantly decreased nasal polypoid lesions (p<0.001), EMT-related markers (p=0.019 for E-cadherin and p=0.002 for vimentin) and the mRNA levels of IL-4 (p<0.001) and IL-17A (p=0.004) compared with the positive control group. Indocyanine Green 32-35 cadherin 1 Mus musculus 143-153 33023995-8 2020 Inhibition of Wnt signaling via ICG-001 resulted in significantly decreased nasal polypoid lesions (p<0.001), EMT-related markers (p=0.019 for E-cadherin and p=0.002 for vimentin) and the mRNA levels of IL-4 (p<0.001) and IL-17A (p=0.004) compared with the positive control group. Indocyanine Green 32-35 vimentin Homo sapiens 170-178 33023995-8 2020 Inhibition of Wnt signaling via ICG-001 resulted in significantly decreased nasal polypoid lesions (p<0.001), EMT-related markers (p=0.019 for E-cadherin and p=0.002 for vimentin) and the mRNA levels of IL-4 (p<0.001) and IL-17A (p=0.004) compared with the positive control group. Indocyanine Green 32-35 interleukin 4 Homo sapiens 203-207 33023995-8 2020 Inhibition of Wnt signaling via ICG-001 resulted in significantly decreased nasal polypoid lesions (p<0.001), EMT-related markers (p=0.019 for E-cadherin and p=0.002 for vimentin) and the mRNA levels of IL-4 (p<0.001) and IL-17A (p=0.004) compared with the positive control group. Indocyanine Green 32-35 interleukin 17A Homo sapiens 222-228 32657925-7 2020 In patients receiving the optimized ICG injection, there was significantly increased likelihood of SLN identification with radiologically solid nodules compared to sub-solid nodules (77.4% vs 33.3%, P = 0.04) and anatomic resection compared to wedge resection (88.2% vs 52.2%, P = 0.04). Indocyanine Green 36-39 sarcolipin Homo sapiens 99-102 33141531-0 2020 Indocyanine Green Angiography Predicts Tissue Necrosis More Accurately Than Thermal Imaging and Near-Infrared Spectroscopy in a Rat Perforator Flap Model. Indocyanine Green 0-17 arachidonate 5-lipoxygenase activating protein Rattus norvegicus 143-147 32274795-1 2020 Sieghenthaler et al1 published on the role of indocyanine green and near-infrared-vision (NIR-ICG) in the management of endometriosis, investigating not only the diagnostic value of NIR-ICG, but also the parameters that alter its detection-rate. Indocyanine Green 46-63 ephrin A5 Homo sapiens 17-20 33209203-9 2020 Furthermore, hepatocyte like-cells in the HCCS group showed improved LDL and ICG uptake than those in the other groups. Indocyanine Green 77-80 holocytochrome c synthase Homo sapiens 42-46 32593714-0 2020 The impact of a heterozygous SLCO1B3 null variant on the indocyanine green retention test. Indocyanine Green 57-74 solute carrier organic anion transporter family member 1B3 Homo sapiens 29-36 32593714-2 2020 OATP1B3 (gene symbol: SLCO1B3) is the major transporter for hepatic ICG uptake. Indocyanine Green 68-71 solute carrier organic anion transporter family member 1B3 Homo sapiens 0-7 32593714-2 2020 OATP1B3 (gene symbol: SLCO1B3) is the major transporter for hepatic ICG uptake. Indocyanine Green 68-71 solute carrier organic anion transporter family member 1B3 Homo sapiens 22-29 32458127-6 2020 Our study also investigated the expression level of organic anion transporting polypeptide (OATP) 1B3 and OATP1B1/1B3, which is related to the uptake of ICG and gadoxetic acid into hepatocytes. Indocyanine Green 153-156 solute carrier organic anion transporter family member 1B3 Homo sapiens 52-101 32458127-6 2020 Our study also investigated the expression level of organic anion transporting polypeptide (OATP) 1B3 and OATP1B1/1B3, which is related to the uptake of ICG and gadoxetic acid into hepatocytes. Indocyanine Green 153-156 solute carrier organic anion transporter family member 1B1 Homo sapiens 106-117 32929336-0 2020 Near-infrared fluorescence imaging-guided focused ultrasound-mediated therapy against Rheumatoid Arthritis by MTX-ICG-loaded iRGD-modified echogenic liposomes. Indocyanine Green 114-117 interferon gamma inducible protein 47 Mus musculus 125-129 32519363-2 2020 Here, we demonstrate the feasibility of indocyanine green near-infrared fluorescence (ICG-NIRF) dental imaging for the detection of enamel cracks and enamel-dentin cracks in vitro in the first (ICG-NIRF-I, 700-950 nm) and second (ICG-NIRF-II, 950-1700 nm) imaging windows with transmission excitation light, and compared ICG-NIRF with conventional NIR illumination-II (NIRi-II) and X-ray imaging. Indocyanine Green 40-57 interleukin 17B Homo sapiens 90-94 32519363-2 2020 Here, we demonstrate the feasibility of indocyanine green near-infrared fluorescence (ICG-NIRF) dental imaging for the detection of enamel cracks and enamel-dentin cracks in vitro in the first (ICG-NIRF-I, 700-950 nm) and second (ICG-NIRF-II, 950-1700 nm) imaging windows with transmission excitation light, and compared ICG-NIRF with conventional NIR illumination-II (NIRi-II) and X-ray imaging. Indocyanine Green 40-57 interleukin 17B Homo sapiens 198-202 32519363-2 2020 Here, we demonstrate the feasibility of indocyanine green near-infrared fluorescence (ICG-NIRF) dental imaging for the detection of enamel cracks and enamel-dentin cracks in vitro in the first (ICG-NIRF-I, 700-950 nm) and second (ICG-NIRF-II, 950-1700 nm) imaging windows with transmission excitation light, and compared ICG-NIRF with conventional NIR illumination-II (NIRi-II) and X-ray imaging. Indocyanine Green 40-57 interleukin 17B Homo sapiens 198-202 32519363-2 2020 Here, we demonstrate the feasibility of indocyanine green near-infrared fluorescence (ICG-NIRF) dental imaging for the detection of enamel cracks and enamel-dentin cracks in vitro in the first (ICG-NIRF-I, 700-950 nm) and second (ICG-NIRF-II, 950-1700 nm) imaging windows with transmission excitation light, and compared ICG-NIRF with conventional NIR illumination-II (NIRi-II) and X-ray imaging. Indocyanine Green 40-57 interleukin 17B Homo sapiens 198-202 32609105-0 2020 Intravenous anti-VEGF agents with RGD peptide-targeted core cross-linked star (CCS) polymers modified with indocyanine green for imaging and treatment of laser-induced choroidal neovascularization. Indocyanine Green 107-124 vascular endothelial growth factor A Homo sapiens 17-21 32929336-4 2020 Methods: This study developed iRGD peptide-functionalized echogenic liposomes (iELPs) which encapsulates MTX and indocyanine green (ICG) fluorescent probe through the thin film-hydration method. Indocyanine Green 113-130 interferon gamma inducible protein 47 Mus musculus 30-34 32929336-4 2020 Methods: This study developed iRGD peptide-functionalized echogenic liposomes (iELPs) which encapsulates MTX and indocyanine green (ICG) fluorescent probe through the thin film-hydration method. Indocyanine Green 132-135 interferon gamma inducible protein 47 Mus musculus 30-34 32315999-3 2020 Precisely, Human Serum Albumin (HSA) NPs loaded with two different FDA approved dyes, namely Indocyanine Green (ICG) and Fluorescein isothiocyanate (FITC), with fluorescence response in the near-infrared and visible spectral domains, respectively, have been successfully designed. Indocyanine Green 93-110 albumin Homo sapiens 17-30 30923132-8 2020 Late-phase indocyanine green angiography showed a reduced cyanescence centred to the posterior pole in 11 of 14 examined subjects with monoallelic ABCC6 mutations. Indocyanine Green 11-28 ATP binding cassette subfamily C member 6 Homo sapiens 147-152 32315999-3 2020 Precisely, Human Serum Albumin (HSA) NPs loaded with two different FDA approved dyes, namely Indocyanine Green (ICG) and Fluorescein isothiocyanate (FITC), with fluorescence response in the near-infrared and visible spectral domains, respectively, have been successfully designed. Indocyanine Green 112-115 albumin Homo sapiens 17-30 32500886-4 2020 Enlightened by the concept of metal-organic frameworks, we developed a novel self-recognizing metal-coordinated nanotheranostic agent by the coordination-driven co-assembly of photosensitizer indocyanine green (ICG) and chemo-drug methotrexate (MTX, also served as a specific "targeting ligand" towards folate receptors), in which ferric (FeIII) ions acted as a bridge to tightly associate ICG with MTX. Indocyanine Green 192-209 metaxin 1 Homo sapiens 245-248 32500886-4 2020 Enlightened by the concept of metal-organic frameworks, we developed a novel self-recognizing metal-coordinated nanotheranostic agent by the coordination-driven co-assembly of photosensitizer indocyanine green (ICG) and chemo-drug methotrexate (MTX, also served as a specific "targeting ligand" towards folate receptors), in which ferric (FeIII) ions acted as a bridge to tightly associate ICG with MTX. Indocyanine Green 192-209 metaxin 1 Homo sapiens 399-402 32500886-4 2020 Enlightened by the concept of metal-organic frameworks, we developed a novel self-recognizing metal-coordinated nanotheranostic agent by the coordination-driven co-assembly of photosensitizer indocyanine green (ICG) and chemo-drug methotrexate (MTX, also served as a specific "targeting ligand" towards folate receptors), in which ferric (FeIII) ions acted as a bridge to tightly associate ICG with MTX. Indocyanine Green 211-214 metaxin 1 Homo sapiens 245-248 32500886-4 2020 Enlightened by the concept of metal-organic frameworks, we developed a novel self-recognizing metal-coordinated nanotheranostic agent by the coordination-driven co-assembly of photosensitizer indocyanine green (ICG) and chemo-drug methotrexate (MTX, also served as a specific "targeting ligand" towards folate receptors), in which ferric (FeIII) ions acted as a bridge to tightly associate ICG with MTX. Indocyanine Green 211-214 metaxin 1 Homo sapiens 399-402 32459249-2 2020 Herein, in order to prevent intermolecular accumulation and improve photostability, indocyanine green (ICG) is spontaneously adsorbed onto a covalent organic framework (COF) with high affinity through pi-pi conjugation, and then chicken ovalbumin (OVA) is coated on the surface of COF@ICG via an electrostatic interaction force. Indocyanine Green 84-101 ovalbumin (SERPINB14) Gallus gallus 237-246 32802183-5 2020 Methods: The TME-sensitive nanosystems MCC were easily prepared through the self-assembly of iodinated indocyanine green (ICG) derivative CyI and chitosan, after which the MnO2 nanoparticles were formed as a shell by electrostatic interaction and Mn-N coordinate bonding. Indocyanine Green 122-125 cyclin I Homo sapiens 138-141 32548979-3 2020 Then, through a stepwise assembly strategy, another bio-MOFs structure consisting of Gd3+ ions and 1,3,5-benzenetricarboxylic acid (H3 BTC) is wrapped on the surfaces of Fe-DOX nanoparticles, followed by adsorbing photosensitizer indocyanine green (ICG). Indocyanine Green 230-247 GRDX Homo sapiens 85-88 32548979-3 2020 Then, through a stepwise assembly strategy, another bio-MOFs structure consisting of Gd3+ ions and 1,3,5-benzenetricarboxylic acid (H3 BTC) is wrapped on the surfaces of Fe-DOX nanoparticles, followed by adsorbing photosensitizer indocyanine green (ICG). Indocyanine Green 249-252 GRDX Homo sapiens 85-88 32037007-3 2020 Here, we developed a cyclic Arg-Gly-Asp-Phe-Lys peptide (cRGD) modified and near-infrared (NIR) light triggered disintegratable liposomal nanoplatform (PAM/Pt@IcLipo), where photosensitizer indocyanine green (ICG) was loaded in the out layer and polyamindoamine (PAMAM) dendrimers grafting cisplatin prodrug (PAM/Pt) were encapsulated inside. Indocyanine Green 190-207 peptidylglycine alpha-amidating monooxygenase Homo sapiens 152-155 32037007-3 2020 Here, we developed a cyclic Arg-Gly-Asp-Phe-Lys peptide (cRGD) modified and near-infrared (NIR) light triggered disintegratable liposomal nanoplatform (PAM/Pt@IcLipo), where photosensitizer indocyanine green (ICG) was loaded in the out layer and polyamindoamine (PAMAM) dendrimers grafting cisplatin prodrug (PAM/Pt) were encapsulated inside. Indocyanine Green 209-212 peptidylglycine alpha-amidating monooxygenase Homo sapiens 152-155 32037007-6 2020 When irradiated by NIR light locally at tumor site, ICG heating detonated the thermosensitive liposomes to release the small sized PAM/Pt nanoparticles (~8.6 nm), which were capable of penetrating into the deep tumor tissue. Indocyanine Green 52-55 peptidylglycine alpha-amidating monooxygenase Homo sapiens 131-134 32459249-2 2020 Herein, in order to prevent intermolecular accumulation and improve photostability, indocyanine green (ICG) is spontaneously adsorbed onto a covalent organic framework (COF) with high affinity through pi-pi conjugation, and then chicken ovalbumin (OVA) is coated on the surface of COF@ICG via an electrostatic interaction force. Indocyanine Green 84-101 ovalbumin (SERPINB14) Gallus gallus 248-251 32590635-0 2020 Intraoperative Assessment of DIEP Flap Breast Reconstruction Using Indocyanine Green Angiography: Reduction of Fat Necrosis, Resection Volumes, and Postoperative Surveillance. Indocyanine Green 67-84 FAT atypical cadherin 1 Homo sapiens 111-114 32370916-14 2020 Fluorescent anti-CEA nanobodies have labeling kinetics that approach the speed of nonspecific dyes such as indocyanine green but with the specificity of antibodies. Indocyanine Green 107-124 carcinoembryonic antigen gene family Mus musculus 17-20 32666749-0 2020 The Effect of Indocyanine Green Antimicrobial Photothermal/Photodynamic Therapy on the Expression of BCL-2 and BAX Messenger RNA Levels in Human Gingival Fibroblast Cells. Indocyanine Green 14-31 BCL2 apoptosis regulator Homo sapiens 101-106 32590635-1 2020 BACKGROUND: This study aims to characterize the effect of laser-assisted indocyanine green fluorescence angiography on fat necrosis and flap failure in deep inferior epigastric artery perforator (DIEP) flap breast reconstruction. Indocyanine Green 73-90 FAT atypical cadherin 1 Homo sapiens 119-122 32590635-7 2020 Indocyanine green angiography was used for 200 flaps and was independently associated with a decrease in the odds of fat necrosis (OR, 0.38; p = 0.004). Indocyanine Green 0-17 FAT atypical cadherin 1 Homo sapiens 117-120 32590635-12 2020 CONCLUSION: Intraoperative indocyanine green fluorescence angiography decreases the odds of fat necrosis, saves volume when flap trimming at inset, and can significantly reduce the postoperative surveillance burden in DIEP-based breast reconstruction. Indocyanine Green 27-44 FAT atypical cadherin 1 Homo sapiens 92-95 32666749-0 2020 The Effect of Indocyanine Green Antimicrobial Photothermal/Photodynamic Therapy on the Expression of BCL-2 and BAX Messenger RNA Levels in Human Gingival Fibroblast Cells. Indocyanine Green 14-31 BCL2 associated X, apoptosis regulator Homo sapiens 111-114 32606678-1 2020 Objective: To construct prostate-specific membrane antigen (PSMA)-targeting, indocyanine green (ICG)-loaded nanobubbles (NBs) for multimodal (ultrasound, photoacoustic and fluorescence) imaging of prostate cancer. Indocyanine Green 96-99 folate hydrolase 1 Homo sapiens 24-58 32606678-1 2020 Objective: To construct prostate-specific membrane antigen (PSMA)-targeting, indocyanine green (ICG)-loaded nanobubbles (NBs) for multimodal (ultrasound, photoacoustic and fluorescence) imaging of prostate cancer. Indocyanine Green 96-99 folate hydrolase 1 Homo sapiens 60-64 32461006-0 2020 Results of Green Indocyanine in the Use of the R1T1 Robot as Aid in the Pre-operative Process of Hepatic Organ Transplant: Experiment in Wistar Rats. Indocyanine Green 11-28 activation-induced cytidine deaminase Rattus norvegicus 61-64 32606678-3 2020 Then, PSMA-binding peptides were connected to the surface of ICG NBs using the biotin-avidin method to make targeted photoacoustic NBs, namely, PSMAP/ICG NBs. Indocyanine Green 61-64 folate hydrolase 1 Homo sapiens 6-10 32606678-3 2020 Then, PSMA-binding peptides were connected to the surface of ICG NBs using the biotin-avidin method to make targeted photoacoustic NBs, namely, PSMAP/ICG NBs. Indocyanine Green 150-153 folate hydrolase 1 Homo sapiens 6-10 32203567-7 2020 Additionally, treatment with either ICG-001 or E7386, which are both small molecule inhibitors of beta-catenin/CBP signaling, leads to increased transcriptional expression of fucosyltransferases FUT2 and FUT3, with a concomitant increase in EGFR N-glycan antennary fucosylation. Indocyanine Green 36-39 catenin beta 1 Homo sapiens 98-110 32203567-7 2020 Additionally, treatment with either ICG-001 or E7386, which are both small molecule inhibitors of beta-catenin/CBP signaling, leads to increased transcriptional expression of fucosyltransferases FUT2 and FUT3, with a concomitant increase in EGFR N-glycan antennary fucosylation. Indocyanine Green 36-39 CREB binding protein Homo sapiens 111-114 32203567-7 2020 Additionally, treatment with either ICG-001 or E7386, which are both small molecule inhibitors of beta-catenin/CBP signaling, leads to increased transcriptional expression of fucosyltransferases FUT2 and FUT3, with a concomitant increase in EGFR N-glycan antennary fucosylation. Indocyanine Green 36-39 fucosyltransferase 2 Homo sapiens 195-199 32203567-7 2020 Additionally, treatment with either ICG-001 or E7386, which are both small molecule inhibitors of beta-catenin/CBP signaling, leads to increased transcriptional expression of fucosyltransferases FUT2 and FUT3, with a concomitant increase in EGFR N-glycan antennary fucosylation. Indocyanine Green 36-39 fucosyltransferase 3 (Lewis blood group) Homo sapiens 204-208 32203567-7 2020 Additionally, treatment with either ICG-001 or E7386, which are both small molecule inhibitors of beta-catenin/CBP signaling, leads to increased transcriptional expression of fucosyltransferases FUT2 and FUT3, with a concomitant increase in EGFR N-glycan antennary fucosylation. Indocyanine Green 36-39 epidermal growth factor receptor Homo sapiens 241-245 31538195-2 2020 OBJECTIVE: To conduct a retrospective case-control study with indocyanine green (ICG) intensity analysis of the superficial temporal artery-middle cerebral artery (STA-MCA) bypass and investigate whether its washout pattern might be a marker for intraoperative prediction of CHS. Indocyanine Green 62-79 GCY Homo sapiens 164-167 31538195-2 2020 OBJECTIVE: To conduct a retrospective case-control study with indocyanine green (ICG) intensity analysis of the superficial temporal artery-middle cerebral artery (STA-MCA) bypass and investigate whether its washout pattern might be a marker for intraoperative prediction of CHS. Indocyanine Green 81-84 GCY Homo sapiens 164-167 32269223-2 2020 Here, we report a H2O2/O2 self-supplying nanoagent, (MSNs@CaO2-ICG)@LA, which consists of manganese silicate (MSN)-supported calcium peroxide (CaO2) and indocyanine green (ICG) with further surface modification of phase-change material lauric acid (LA). Indocyanine Green 153-170 moesin Homo sapiens 53-56 32368886-4 2020 A BB/PEG/ICG grafted poly(aspartic acid) comb-like functional polymer was firstly synthesized and conjugated with transferrin to form a transferrin-polymer-drug conjugate (Tf-P(BB)), which showed 120 % increase in HepG2 hepatoma (Tf receptor overexpression) cell uptake compared to non-targeting protein-polymer-drug conjugate (HRP-P(BB)). Indocyanine Green 9-12 transferrin Homo sapiens 114-125 32368886-4 2020 A BB/PEG/ICG grafted poly(aspartic acid) comb-like functional polymer was firstly synthesized and conjugated with transferrin to form a transferrin-polymer-drug conjugate (Tf-P(BB)), which showed 120 % increase in HepG2 hepatoma (Tf receptor overexpression) cell uptake compared to non-targeting protein-polymer-drug conjugate (HRP-P(BB)). Indocyanine Green 9-12 transferrin Homo sapiens 136-147 32058253-3 2020 To address the challenges, we have developed a biomimetic and stable design based on bovine serum albumin (BSA) nanoparticles that are encapsulated with a hydrophilic photothermal agent, indocyanine green (ICG), as well as a hydrophobic agent, gambogic acid (GA), via the desolvation method. Indocyanine Green 206-209 albumin Mus musculus 92-105 32236787-1 2020 The regularities of the electron excitations exchange in hybrid associates of colloidal Ag2S quantum dots, passivated with thioglycolic acid (Ag2S/TGA QDs) with an average size of 2.2 and 3.7 nm with Indocyanine Green J-aggregates (ICG) were studied in this work by methods of absorption and luminescence spectroscopy. Indocyanine Green 200-217 angiotensin II receptor type 1 Homo sapiens 88-92 32269223-2 2020 Here, we report a H2O2/O2 self-supplying nanoagent, (MSNs@CaO2-ICG)@LA, which consists of manganese silicate (MSN)-supported calcium peroxide (CaO2) and indocyanine green (ICG) with further surface modification of phase-change material lauric acid (LA). Indocyanine Green 63-66 moesin Homo sapiens 53-56 32119183-8 2020 CXCR4-induced renal fibrosis was inhibited by treatment with ICG-001, an inhibitor of beta-catenin signalling. Indocyanine Green 61-64 C-X-C motif chemokine receptor 4 Homo sapiens 0-5 32119183-8 2020 CXCR4-induced renal fibrosis was inhibited by treatment with ICG-001, an inhibitor of beta-catenin signalling. Indocyanine Green 61-64 catenin beta 1 Homo sapiens 86-98 31140111-8 2020 Moreover, nude mice were injected with NTCP inhibitors and ICG, and subsequently, their ICG signal was examined in vivo and in the blood. Indocyanine Green 88-91 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 Mus musculus 39-43 31140111-9 2020 RESULTS: In the reporter study, the ICG signal was higher in NTCP-expressing cells/tumors than in control cells/tumors after ICG treatment. Indocyanine Green 36-39 solute carrier family 10 member 1 Homo sapiens 61-65 31140111-1 2020 PURPOSE: Sodium taurocholate cotransporting polypeptide (NTCP) is a transmembrane protein responsible for delivering indocyanine green (ICG), an ideal infrared fluorescent dye, from extracellular space into the cytoplasm. Indocyanine Green 117-134 solute carrier family 10 member 1 Homo sapiens 9-55 31140111-1 2020 PURPOSE: Sodium taurocholate cotransporting polypeptide (NTCP) is a transmembrane protein responsible for delivering indocyanine green (ICG), an ideal infrared fluorescent dye, from extracellular space into the cytoplasm. Indocyanine Green 117-134 solute carrier family 10 member 1 Homo sapiens 57-61 31140111-9 2020 RESULTS: In the reporter study, the ICG signal was higher in NTCP-expressing cells/tumors than in control cells/tumors after ICG treatment. Indocyanine Green 125-128 solute carrier family 10 member 1 Homo sapiens 61-65 31140111-1 2020 PURPOSE: Sodium taurocholate cotransporting polypeptide (NTCP) is a transmembrane protein responsible for delivering indocyanine green (ICG), an ideal infrared fluorescent dye, from extracellular space into the cytoplasm. Indocyanine Green 136-139 solute carrier family 10 member 1 Homo sapiens 9-55 31140111-10 2020 In the drug-screening platform study, NTCP-expressing cells had decreased ICG intensity after treatment with NTCP inhibitors and ICG. Indocyanine Green 74-77 solute carrier family 10 member 1 Homo sapiens 38-42 31140111-1 2020 PURPOSE: Sodium taurocholate cotransporting polypeptide (NTCP) is a transmembrane protein responsible for delivering indocyanine green (ICG), an ideal infrared fluorescent dye, from extracellular space into the cytoplasm. Indocyanine Green 136-139 solute carrier family 10 member 1 Homo sapiens 57-61 31140111-10 2020 In the drug-screening platform study, NTCP-expressing cells had decreased ICG intensity after treatment with NTCP inhibitors and ICG. Indocyanine Green 74-77 solute carrier family 10 member 1 Homo sapiens 109-113 31140111-10 2020 In the drug-screening platform study, NTCP-expressing cells had decreased ICG intensity after treatment with NTCP inhibitors and ICG. Indocyanine Green 129-132 solute carrier family 10 member 1 Homo sapiens 38-42 31140111-6 2020 Furthermore, ICG was administrated to NTCP-expressing tumor-bearing nude mice and examined using the IVIS. Indocyanine Green 13-16 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 Mus musculus 38-42 32209977-4 2020 Sodium taurocholate cotransporting polypeptide (NTCP), belonging to the same family as ASBT, has fluorescein 5(6)-isothiocyanate (FITC) and indocyanine green (ICG) transportability. Indocyanine Green 140-157 solute carrier family 10 member 1 Homo sapiens 0-46 31286194-0 2020 Best practices in near-infrared fluorescence imaging with indocyanine green (NIRF/ICG)-guided robotic urologic surgery: a systematic review-based expert consensus. Indocyanine Green 58-75 interleukin 17B Homo sapiens 77-81 31286194-1 2020 PURPOSE: The aim of the present study is to investigate the impact of the near-infrared (NIRF) technology with indocyanine green (ICG) in robotic urologic surgery by performing a systematic literature review and to provide evidence-based expert recommendations on best practices in this field. Indocyanine Green 111-128 interleukin 17B Homo sapiens 89-93 31286194-1 2020 PURPOSE: The aim of the present study is to investigate the impact of the near-infrared (NIRF) technology with indocyanine green (ICG) in robotic urologic surgery by performing a systematic literature review and to provide evidence-based expert recommendations on best practices in this field. Indocyanine Green 130-133 interleukin 17B Homo sapiens 89-93 32209977-4 2020 Sodium taurocholate cotransporting polypeptide (NTCP), belonging to the same family as ASBT, has fluorescein 5(6)-isothiocyanate (FITC) and indocyanine green (ICG) transportability. Indocyanine Green 140-157 solute carrier family 10 member 1 Homo sapiens 48-52 32209977-4 2020 Sodium taurocholate cotransporting polypeptide (NTCP), belonging to the same family as ASBT, has fluorescein 5(6)-isothiocyanate (FITC) and indocyanine green (ICG) transportability. Indocyanine Green 140-157 solute carrier family 10 member 2 Homo sapiens 87-91 32209977-4 2020 Sodium taurocholate cotransporting polypeptide (NTCP), belonging to the same family as ASBT, has fluorescein 5(6)-isothiocyanate (FITC) and indocyanine green (ICG) transportability. Indocyanine Green 159-162 solute carrier family 10 member 1 Homo sapiens 0-46 32209977-4 2020 Sodium taurocholate cotransporting polypeptide (NTCP), belonging to the same family as ASBT, has fluorescein 5(6)-isothiocyanate (FITC) and indocyanine green (ICG) transportability. Indocyanine Green 159-162 solute carrier family 10 member 1 Homo sapiens 48-52 32209977-4 2020 Sodium taurocholate cotransporting polypeptide (NTCP), belonging to the same family as ASBT, has fluorescein 5(6)-isothiocyanate (FITC) and indocyanine green (ICG) transportability. Indocyanine Green 159-162 solute carrier family 10 member 2 Homo sapiens 87-91 32209977-10 2020 ICG and FITC were validated and shown to be transported by ASBT. Indocyanine Green 0-3 solute carrier family 10, member 2 Mus musculus 59-63 31820663-4 2020 Furthermore, indocyanine green (ICG) was loaded inside LDL/SLN to establish a drug delivery system (DDS) fit for tumor-specific PTT of breast cancer. Indocyanine Green 13-30 sarcolipin Homo sapiens 59-62 32096499-2 2020 Herein, we engineered a human epidermal growth factor receptor 2 (HER2) affibody to the surface of cell membrane nanovesicles (A-NVs) in a ligand-oriented manner and loaded them with indocyanine green (ICG) as precision theranostics for PHCC treatment. Indocyanine Green 183-200 erb-b2 receptor tyrosine kinase 2 Homo sapiens 30-64 32096499-2 2020 Herein, we engineered a human epidermal growth factor receptor 2 (HER2) affibody to the surface of cell membrane nanovesicles (A-NVs) in a ligand-oriented manner and loaded them with indocyanine green (ICG) as precision theranostics for PHCC treatment. Indocyanine Green 183-200 erb-b2 receptor tyrosine kinase 2 Homo sapiens 66-70 32096499-2 2020 Herein, we engineered a human epidermal growth factor receptor 2 (HER2) affibody to the surface of cell membrane nanovesicles (A-NVs) in a ligand-oriented manner and loaded them with indocyanine green (ICG) as precision theranostics for PHCC treatment. Indocyanine Green 202-205 erb-b2 receptor tyrosine kinase 2 Homo sapiens 30-64 32096499-2 2020 Herein, we engineered a human epidermal growth factor receptor 2 (HER2) affibody to the surface of cell membrane nanovesicles (A-NVs) in a ligand-oriented manner and loaded them with indocyanine green (ICG) as precision theranostics for PHCC treatment. Indocyanine Green 202-205 erb-b2 receptor tyrosine kinase 2 Homo sapiens 66-70 32096524-3 2020 Benefiting from the pH-responsive properties and the assistance of near infrared (NIR) laser irradiation, the outer shell Fe3+-tannic acid (TA) complexes of PID@Fe-TA can be easily degraded into Fe3+ and TA as well as to release chemotherapeutic drugs (doxorubicin, DOX) and photothermal transforming agents (indocyanine green, ICG) in a tumor microenvironment (TME) or cancer cells. Indocyanine Green 309-326 metastasis associated 1 family member 2 Homo sapiens 157-160 32096524-3 2020 Benefiting from the pH-responsive properties and the assistance of near infrared (NIR) laser irradiation, the outer shell Fe3+-tannic acid (TA) complexes of PID@Fe-TA can be easily degraded into Fe3+ and TA as well as to release chemotherapeutic drugs (doxorubicin, DOX) and photothermal transforming agents (indocyanine green, ICG) in a tumor microenvironment (TME) or cancer cells. Indocyanine Green 328-331 metastasis associated 1 family member 2 Homo sapiens 157-160 32183838-0 2020 Rationally assembled albumin/indocyanine green nanocomplex for enhanced tumor imaging to guide photothermal therapy. Indocyanine Green 29-46 albumin Homo sapiens 21-28 32183838-1 2020 Herein, a novel phototheranostic nanocomplex that is self-assembled from bovine serum albumin (BSA) and indocyanine green (ICG) is developed for enhanced near-infrared (NIR) fluorescence imaging, which benefits the guidance on in vivo cancer photothermal therapy (PTT). Indocyanine Green 104-121 albumin Homo sapiens 80-93 32183838-1 2020 Herein, a novel phototheranostic nanocomplex that is self-assembled from bovine serum albumin (BSA) and indocyanine green (ICG) is developed for enhanced near-infrared (NIR) fluorescence imaging, which benefits the guidance on in vivo cancer photothermal therapy (PTT). Indocyanine Green 123-126 albumin Homo sapiens 80-93 32292513-5 2020 Methods: Silk-elastinlike protein (SELP) polymers were employed as liquid embolic vehicles for delivery of a clinically used near-infrared dye, indocyanine green (ICG). Indocyanine Green 144-161 selectin P Homo sapiens 9-33 32292513-5 2020 Methods: Silk-elastinlike protein (SELP) polymers were employed as liquid embolic vehicles for delivery of a clinically used near-infrared dye, indocyanine green (ICG). Indocyanine Green 144-161 selectin P Homo sapiens 35-39 32292513-5 2020 Methods: Silk-elastinlike protein (SELP) polymers were employed as liquid embolic vehicles for delivery of a clinically used near-infrared dye, indocyanine green (ICG). Indocyanine Green 163-166 selectin P Homo sapiens 9-33 32292513-5 2020 Methods: Silk-elastinlike protein (SELP) polymers were employed as liquid embolic vehicles for delivery of a clinically used near-infrared dye, indocyanine green (ICG). Indocyanine Green 163-166 selectin P Homo sapiens 35-39 31820570-3 2020 In this study, a clinically-integrated nanoliposome containing sertraline hydrochloride and indocyanine green (ICG), here named as Ser/ICG@Lip, was successfully synthesized by film dispersion and hydration-sonication methods. Indocyanine Green 92-109 SMG1 nonsense mediated mRNA decay associated PI3K related kinase Homo sapiens 139-142 31820570-3 2020 In this study, a clinically-integrated nanoliposome containing sertraline hydrochloride and indocyanine green (ICG), here named as Ser/ICG@Lip, was successfully synthesized by film dispersion and hydration-sonication methods. Indocyanine Green 111-114 SMG1 nonsense mediated mRNA decay associated PI3K related kinase Homo sapiens 139-142 31820570-3 2020 In this study, a clinically-integrated nanoliposome containing sertraline hydrochloride and indocyanine green (ICG), here named as Ser/ICG@Lip, was successfully synthesized by film dispersion and hydration-sonication methods. Indocyanine Green 135-138 SMG1 nonsense mediated mRNA decay associated PI3K related kinase Homo sapiens 139-142 32022524-0 2020 Editorial Comment: Best practices in near-infrared fluorescence imaging with indocyanine green (NIRF/ICG)-guided robotic urologic surgery: a systematic review-based expert consensus. Indocyanine Green 77-94 interleukin 17B Homo sapiens 96-100 31820663-6 2020 Additionally, LDL/SLN/ICG could smartly target the MCF-7 cells that overexpress LDLR. Indocyanine Green 22-25 sarcolipin Homo sapiens 18-21 31820663-6 2020 Additionally, LDL/SLN/ICG could smartly target the MCF-7 cells that overexpress LDLR. Indocyanine Green 22-25 low density lipoprotein receptor Homo sapiens 80-84 31820663-9 2020 Moreover, the LDL modification was able to enhance the tumor accumulation of LDL/SLN/ICG, which finally achieved elevated PTT benefits than other groups. Indocyanine Green 85-88 sarcolipin Homo sapiens 81-84 31820663-4 2020 Furthermore, indocyanine green (ICG) was loaded inside LDL/SLN to establish a drug delivery system (DDS) fit for tumor-specific PTT of breast cancer. Indocyanine Green 32-35 sarcolipin Homo sapiens 59-62 32642722-10 2020 We also provide further evidence that ICG-001 inhibits proliferation of NF2-mutant meningioma cells at least partly through attenuating the FOXM1-mediated Wnt/beta-catenin signaling. Indocyanine Green 38-41 neurofibromin 2 Mus musculus 72-75 32097299-0 2020 Intraoperative Laser-Assisted Indocyanine Green Imaging Can Reduce the Rate of Fat Necrosis in Microsurgical Breast Reconstruction. Indocyanine Green 30-47 FAT atypical cadherin 1 Homo sapiens 79-82 32097299-3 2020 The authors hypothesized that incorporation of protocolized indocyanine green-informed flap debridement at the time of surgery would decrease the incidence of fat necrosis. Indocyanine Green 60-77 FAT atypical cadherin 1 Homo sapiens 159-162 32185134-6 2020 Methods: Indocyanine green (ICG) was conjugated with GnRH antagonist peptide to develop an ovarian cancer-selective fluorescence probe GnRHa-ICG. Indocyanine Green 9-26 gonadotropin releasing hormone 1 Mus musculus 53-57 32185134-6 2020 Methods: Indocyanine green (ICG) was conjugated with GnRH antagonist peptide to develop an ovarian cancer-selective fluorescence probe GnRHa-ICG. Indocyanine Green 28-31 gonadotropin releasing hormone 1 Mus musculus 53-57 32185134-14 2020 The fluorescence signal of peritoneal metastases peaked in intensity at 2 h and maintained for up to 48 h. ICG also showed a weak signal in the tumor lesions due to the enhanced permeability and retention effect, but the intensity decreased quickly within 48 h. Conclusions: The developed GnRHR-targeted imaging agent GnRHa-ICG could specifically detected peritoneal tumor lesions from normal peritoneal and intestines tissues because of the modification of GnRHa to ICG. Indocyanine Green 107-110 gonadotropin releasing hormone receptor Mus musculus 289-294 32022444-2 2020 Inspired by the "Y" shape of indocyanine green (ICG), the dye is integrated in an amphiphilic lipopeptide (RNF). Indocyanine Green 29-46 tripartite motif-containing 31 Mus musculus 107-110 32022444-2 2020 Inspired by the "Y" shape of indocyanine green (ICG), the dye is integrated in an amphiphilic lipopeptide (RNF). Indocyanine Green 48-51 tripartite motif-containing 31 Mus musculus 107-110 32642722-10 2020 We also provide further evidence that ICG-001 inhibits proliferation of NF2-mutant meningioma cells at least partly through attenuating the FOXM1-mediated Wnt/beta-catenin signaling. Indocyanine Green 38-41 forkhead box M1 Homo sapiens 140-145 32642722-10 2020 We also provide further evidence that ICG-001 inhibits proliferation of NF2-mutant meningioma cells at least partly through attenuating the FOXM1-mediated Wnt/beta-catenin signaling. Indocyanine Green 38-41 catenin beta 1 Homo sapiens 159-171 31939276-3 2020 This study reports on the development of multifunctional tumor-penetrating mesoporous silica nanoparticles (iMSNs) for simultaneous delivery of siRNA (siPlk1) and miRNA (miR-200c), using encapsulation of a photosensitizer indocyanine green (ICG) to facilitate endosomal escape and surface conjugation of the iRGD peptide to enable deep tumor penetration. Indocyanine Green 222-239 microRNA 200c Homo sapiens 170-178 31836484-6 2020 When the HM-HPMC/beta-CD hydrogel containing indocyanine green (ICG) was subcutaneously administered to mice, the fluorescence of the ICG remained relatively constant for 24 h after the administration, which was substantially longer than that for ICG alone or an HPMC formulation. Indocyanine Green 45-62 beta-carotene oxygenase 1 Mus musculus 17-24 31836484-6 2020 When the HM-HPMC/beta-CD hydrogel containing indocyanine green (ICG) was subcutaneously administered to mice, the fluorescence of the ICG remained relatively constant for 24 h after the administration, which was substantially longer than that for ICG alone or an HPMC formulation. Indocyanine Green 64-67 beta-carotene oxygenase 1 Mus musculus 17-24 31836484-6 2020 When the HM-HPMC/beta-CD hydrogel containing indocyanine green (ICG) was subcutaneously administered to mice, the fluorescence of the ICG remained relatively constant for 24 h after the administration, which was substantially longer than that for ICG alone or an HPMC formulation. Indocyanine Green 134-137 beta-carotene oxygenase 1 Mus musculus 17-24 31836484-6 2020 When the HM-HPMC/beta-CD hydrogel containing indocyanine green (ICG) was subcutaneously administered to mice, the fluorescence of the ICG remained relatively constant for 24 h after the administration, which was substantially longer than that for ICG alone or an HPMC formulation. Indocyanine Green 134-137 beta-carotene oxygenase 1 Mus musculus 17-24 31939276-3 2020 This study reports on the development of multifunctional tumor-penetrating mesoporous silica nanoparticles (iMSNs) for simultaneous delivery of siRNA (siPlk1) and miRNA (miR-200c), using encapsulation of a photosensitizer indocyanine green (ICG) to facilitate endosomal escape and surface conjugation of the iRGD peptide to enable deep tumor penetration. Indocyanine Green 241-244 microRNA 200c Homo sapiens 170-178 31939276-5 2020 Using a galectin-8 recruitment assay, we showed that reactive oxygen species generated by ICG upon light irradiation functioned as an endosomolytic stimulus that caused release of the siRNA/miRNA combination from endosomes. Indocyanine Green 90-93 galectin 8 Homo sapiens 8-18 31939242-9 2020 Univariate analysis showed that preoperative NC, flap type, and intraoperative ICG angiography had significant influence on the incidence of flap-related complications ( P<0.05). Indocyanine Green 79-82 arachidonate 5-lipoxygenase activating protein Homo sapiens 141-145 32104504-7 2020 After NIR light irradiation at tumor site, erythrocyte membrane of GOx-Fe0@EM-A was ruptured to achieve light-driven release and tumor deep penetration of ultra-small nanosize GOx-Fe0 by the photothermal effect of ICG. Indocyanine Green 214-217 hydroxyacid oxidase 1 Homo sapiens 67-70 32104504-7 2020 After NIR light irradiation at tumor site, erythrocyte membrane of GOx-Fe0@EM-A was ruptured to achieve light-driven release and tumor deep penetration of ultra-small nanosize GOx-Fe0 by the photothermal effect of ICG. Indocyanine Green 214-217 hydroxyacid oxidase 1 Homo sapiens 176-179 31939242-10 2020 Multivariate analysis showed that preoperative NC and non-ICG angiography were the risk factors of flap-related complications ( P<0.05), and also the risk factors of regional flap necrosis ( P<0.05). Indocyanine Green 58-61 arachidonate 5-lipoxygenase activating protein Homo sapiens 99-103 31939242-12 2020 The average extra costs in group A was 1 378 yuan less than that in group C. For the patients without NC, intraoperative ICG angiography would increase the average extra costs, which was 747 yuan in group B more than that in group D. Conclusion: In autologous breast reconstruction, ICG angiography can reduce the incidence of flap-related complications, especially the incidence of regional flap necrosis, while NC is the opposite. Indocyanine Green 121-124 arachidonate 5-lipoxygenase activating protein Homo sapiens 327-331 31697035-3 2019 An NIR-II fluorescent molecular probe, indocyanine green (ICG) conjugated bevacizumab (Bev-ICG) that targets vascular endothelial growth factor (VEGF), is successfully synthesized and evaluated along with the NIR-II endoscopy imaging system. Indocyanine Green 39-56 vascular endothelial growth factor A Rattus norvegicus 109-143 31435990-10 2020 RESULTS: GalT-KO and wild-type porcine hepatocytes were successfully immortalized and maintained the characteristics of primary porcine hepatocytes, including albumin secretion, ICG uptake, urea and glycogen production, and expression of hepatocyte marker proteins and specific metabolic enzymes. Indocyanine Green 178-181 galactose-1-phosphate uridylyltransferase Sus scrofa 9-13 31733318-4 2019 MAIN METHODS: An ScFv was conjugated with superparamagnetic iron oxide (SPIO) or indocyanine green (ICG) via a linker by utilizing the reaction between cysteine and maleimide. Indocyanine Green 81-98 immunglobulin heavy chain variable region Homo sapiens 17-21 31733318-4 2019 MAIN METHODS: An ScFv was conjugated with superparamagnetic iron oxide (SPIO) or indocyanine green (ICG) via a linker by utilizing the reaction between cysteine and maleimide. Indocyanine Green 100-103 immunglobulin heavy chain variable region Homo sapiens 17-21 31738019-2 2019 Herein, a biocompatible theranostic nanoplatform capable of simultaneous cancer imaging and therapy is attempted by loading of paclitaxel (PTX) and indocyanine green (ICG) molecules into the matrix of Gd2 O3 @human serum albumin (HSA) nanoparticles (PIGH NPs) via hydrophobic interaction. Indocyanine Green 148-165 phosphatidylinositol glycan anchor biosynthesis, class H Mus musculus 250-254 31738019-2 2019 Herein, a biocompatible theranostic nanoplatform capable of simultaneous cancer imaging and therapy is attempted by loading of paclitaxel (PTX) and indocyanine green (ICG) molecules into the matrix of Gd2 O3 @human serum albumin (HSA) nanoparticles (PIGH NPs) via hydrophobic interaction. Indocyanine Green 167-170 phosphatidylinositol glycan anchor biosynthesis, class H Mus musculus 250-254 31738019-4 2019 Moreover, the PIGH NPs achieve high cellular uptake, efficient cytoplasmic drug translocation based on singlet oxygen-triggered endolysosomal disruption and prominent cytotoxicity effect against 4T1 cells under 808 nm near-infrared (NIR) irradiation in contrast to PTX/ICG-loaded HSA nanoparticles (PIH NPs) and free PTX/ICG. Indocyanine Green 269-272 phosphatidylinositol glycan anchor biosynthesis, class H Mus musculus 14-18 31738019-4 2019 Moreover, the PIGH NPs achieve high cellular uptake, efficient cytoplasmic drug translocation based on singlet oxygen-triggered endolysosomal disruption and prominent cytotoxicity effect against 4T1 cells under 808 nm near-infrared (NIR) irradiation in contrast to PTX/ICG-loaded HSA nanoparticles (PIH NPs) and free PTX/ICG. Indocyanine Green 321-324 phosphatidylinositol glycan anchor biosynthesis, class H Mus musculus 14-18 32188378-6 2020 We followed the ICG containing liposomal nanoparticle uptake into the squamous carcinoma cells (SCC) under a fluorescence microscopy and into SCC tumor in the nude mice orthotopic xenografts model under a surgical microscope. Indocyanine Green 16-19 serpin family B member 3 Homo sapiens 96-99 32188378-9 2020 The SCC cells showed that the ICG containing liposomes bind to cell surface but are not internalized in the SCC-9 cells in 30 minutes" incubation. Indocyanine Green 30-33 serpin family B member 3 Homo sapiens 4-7 32188378-10 2020 We also showed here that ICG containing liposomal nanoparticles can be traced under a surgical camera in vivo in orthotopic SCC xenografts in mice. Indocyanine Green 25-28 serpin family B member 3 Homo sapiens 124-127 31697035-3 2019 An NIR-II fluorescent molecular probe, indocyanine green (ICG) conjugated bevacizumab (Bev-ICG) that targets vascular endothelial growth factor (VEGF), is successfully synthesized and evaluated along with the NIR-II endoscopy imaging system. Indocyanine Green 39-56 vascular endothelial growth factor A Rattus norvegicus 145-149 31697035-3 2019 An NIR-II fluorescent molecular probe, indocyanine green (ICG) conjugated bevacizumab (Bev-ICG) that targets vascular endothelial growth factor (VEGF), is successfully synthesized and evaluated along with the NIR-II endoscopy imaging system. Indocyanine Green 58-61 vascular endothelial growth factor A Rattus norvegicus 109-143 31697035-3 2019 An NIR-II fluorescent molecular probe, indocyanine green (ICG) conjugated bevacizumab (Bev-ICG) that targets vascular endothelial growth factor (VEGF), is successfully synthesized and evaluated along with the NIR-II endoscopy imaging system. Indocyanine Green 58-61 vascular endothelial growth factor A Rattus norvegicus 145-149 31697035-3 2019 An NIR-II fluorescent molecular probe, indocyanine green (ICG) conjugated bevacizumab (Bev-ICG) that targets vascular endothelial growth factor (VEGF), is successfully synthesized and evaluated along with the NIR-II endoscopy imaging system. Indocyanine Green 91-94 vascular endothelial growth factor A Rattus norvegicus 109-143 31697035-3 2019 An NIR-II fluorescent molecular probe, indocyanine green (ICG) conjugated bevacizumab (Bev-ICG) that targets vascular endothelial growth factor (VEGF), is successfully synthesized and evaluated along with the NIR-II endoscopy imaging system. Indocyanine Green 91-94 vascular endothelial growth factor A Rattus norvegicus 145-149 31521887-6 2019 The PKM2 silencing inhibited tumor glycolysis metabolism and further depleted the energy supply for HSPs production, thus overcoming the heat endurance of tumor cells to strengthen ICG-mediated photothermal ablation. Indocyanine Green 181-184 pyruvate kinase M1/2 Homo sapiens 4-8 31174440-4 2019 In addition, indocyanine green (ICG) as a photothermal agent was encapsulated into CM/SLN to finally construct a DDS suitable for tumour-targeted PTT of osteosarcoma. Indocyanine Green 13-30 sarcolipin Homo sapiens 86-89 31174440-4 2019 In addition, indocyanine green (ICG) as a photothermal agent was encapsulated into CM/SLN to finally construct a DDS suitable for tumour-targeted PTT of osteosarcoma. Indocyanine Green 32-35 sarcolipin Homo sapiens 86-89 33778683-2 2019 Previous research has shown that human organic anion-transporting polypeptide 1b3 (OATP1B3) promotes the uptake of the near-infrared fluorescent dye indocyanine green (ICG). Indocyanine Green 149-166 solute carrier organic anion transporter family member 1B3 Homo sapiens 39-81 30798640-6 2019 Furthermore, due to the conjugation of Cet, Cet-SLN/ICG could target EGFR which overexpress in MCF-7 cells. Indocyanine Green 52-55 epidermal growth factor receptor Homo sapiens 69-73 33778683-2 2019 Previous research has shown that human organic anion-transporting polypeptide 1b3 (OATP1B3) promotes the uptake of the near-infrared fluorescent dye indocyanine green (ICG). Indocyanine Green 149-166 solute carrier organic anion transporter family member 1B3 Homo sapiens 83-90 33778683-2 2019 Previous research has shown that human organic anion-transporting polypeptide 1b3 (OATP1B3) promotes the uptake of the near-infrared fluorescent dye indocyanine green (ICG). Indocyanine Green 168-171 solute carrier organic anion transporter family member 1B3 Homo sapiens 39-81 33778683-2 2019 Previous research has shown that human organic anion-transporting polypeptide 1b3 (OATP1B3) promotes the uptake of the near-infrared fluorescent dye indocyanine green (ICG). Indocyanine Green 168-171 solute carrier organic anion transporter family member 1B3 Homo sapiens 83-90 33778683-10 2019 In mice, PAI signals after ICG administration were increased 2.3-fold in OATP1B3 tumors relative to those in controls (P < .05). Indocyanine Green 27-30 solute carrier organic anion transporter family member 1B3 Homo sapiens 73-80 33778683-11 2019 Conclusion: OATP1B3 operates as an in vivo PAI reporter gene based on its ability to promote the cellular uptake of ICG. Indocyanine Green 116-119 solute carrier organic anion transporter family member 1B3 Homo sapiens 12-19 31456905-5 2019 We examined whether indocyanine green (ICG)-mediated PDT-enhanced cell migration is related to CFTR activation. Indocyanine Green 20-37 CF transmembrane conductance regulator Homo sapiens 95-99 31556589-2 2019 In the delivery system, a chemotherapeutic drug (doxorubicin, DOX) and an optotheranostic agent (indocyanine green, ICG) were co-loaded in bovine serum albumin (BSA) via a hydrophobic-interaction-induced self-assembly to form stable DOX&ICG@BSA nanoparticles. Indocyanine Green 116-119 albumin Homo sapiens 146-159 31456905-5 2019 We examined whether indocyanine green (ICG)-mediated PDT-enhanced cell migration is related to CFTR activation. Indocyanine Green 39-42 CF transmembrane conductance regulator Homo sapiens 95-99 31496649-11 2019 Inhibition of Wnt/beta-catenin by ICG-001 significantly reversed the effect of OG on osteogenic and adipogenic differentiation of BMSCs. Indocyanine Green 34-37 catenin beta 1 Homo sapiens 18-30 31300478-4 2019 Combination of alphaPDL1 nanoparticle treatment with near-infrared (NIR) laser irradiation-triggered activation of photosensitizer indocyanine green induces the generation of reactive oxygen species, which promotes the intratumoral infiltration of CTLs and sensitizes the tumors to PDL1 blockade therapy. Indocyanine Green 131-148 CD274 antigen Mus musculus 20-24 31246000-4 2019 Herein, we modified an indocyanine green derivative Cy7 with heavy atom iodine to form a novel NIR dye CyI to improve the reactive oxygen species (ROS) production and heat generation while, at the same time, maintain their fluorescence characteristics for in vivo noninvasive imaging. Indocyanine Green 23-40 cyclin I Homo sapiens 103-106 31082216-0 2019 Affibody-Indocyanine Green Based Contrast Agent for Photoacoustic and Fluorescence Molecular Imaging of B7-H3 Expression in Breast Cancer. Indocyanine Green 9-26 CD276 antigen Mus musculus 104-109 31324005-7 2019 Moreover, we demonstrate for the first time that the complex phenotype caused by the loss of p73 can be rescued in utero by treatment with the small-molecule-specific CBP/beta-catenin antagonist ICG-001. Indocyanine Green 195-198 tumor protein p73 Homo sapiens 93-96 31324005-7 2019 Moreover, we demonstrate for the first time that the complex phenotype caused by the loss of p73 can be rescued in utero by treatment with the small-molecule-specific CBP/beta-catenin antagonist ICG-001. Indocyanine Green 195-198 CREB binding protein Homo sapiens 167-170 31324005-7 2019 Moreover, we demonstrate for the first time that the complex phenotype caused by the loss of p73 can be rescued in utero by treatment with the small-molecule-specific CBP/beta-catenin antagonist ICG-001. Indocyanine Green 195-198 catenin beta 1 Homo sapiens 171-183 31234288-0 2019 Use of Indocyanine Green (ICG), a Medical Near Infrared Dye, for Enhanced Fluorescent Imaging-Comparison of Organic Anion Transporting Polypeptide 1B3 (OATP1B3) and Sodium-Taurocholate Cotransporting Polypeptide (NTCP) Reporter Genes. Indocyanine Green 7-24 solute carrier family 10 member 1 Homo sapiens 213-217 31234288-0 2019 Use of Indocyanine Green (ICG), a Medical Near Infrared Dye, for Enhanced Fluorescent Imaging-Comparison of Organic Anion Transporting Polypeptide 1B3 (OATP1B3) and Sodium-Taurocholate Cotransporting Polypeptide (NTCP) Reporter Genes. Indocyanine Green 26-29 solute carrier organic anion transporter family member 1B3 Homo sapiens 152-159 31234288-0 2019 Use of Indocyanine Green (ICG), a Medical Near Infrared Dye, for Enhanced Fluorescent Imaging-Comparison of Organic Anion Transporting Polypeptide 1B3 (OATP1B3) and Sodium-Taurocholate Cotransporting Polypeptide (NTCP) Reporter Genes. Indocyanine Green 26-29 solute carrier family 10 member 1 Homo sapiens 165-211 31234288-0 2019 Use of Indocyanine Green (ICG), a Medical Near Infrared Dye, for Enhanced Fluorescent Imaging-Comparison of Organic Anion Transporting Polypeptide 1B3 (OATP1B3) and Sodium-Taurocholate Cotransporting Polypeptide (NTCP) Reporter Genes. Indocyanine Green 26-29 solute carrier family 10 member 1 Homo sapiens 213-217 31234288-3 2019 Both sodium taurocholate cotransporting polypeptide (NTCP) and organic-anion-transporting polypeptide 1B3 (OATP1B3) are capable of carrying indocyanine green (ICG) into the cytoplasm. Indocyanine Green 140-157 solute carrier family 10 member 1 Homo sapiens 5-51 31234288-3 2019 Both sodium taurocholate cotransporting polypeptide (NTCP) and organic-anion-transporting polypeptide 1B3 (OATP1B3) are capable of carrying indocyanine green (ICG) into the cytoplasm. Indocyanine Green 140-157 solute carrier family 10 member 1 Homo sapiens 53-57 31234288-3 2019 Both sodium taurocholate cotransporting polypeptide (NTCP) and organic-anion-transporting polypeptide 1B3 (OATP1B3) are capable of carrying indocyanine green (ICG) into the cytoplasm. Indocyanine Green 140-157 solute carrier organic anion transporter family member 1B3 Homo sapiens 63-105 31234288-3 2019 Both sodium taurocholate cotransporting polypeptide (NTCP) and organic-anion-transporting polypeptide 1B3 (OATP1B3) are capable of carrying indocyanine green (ICG) into the cytoplasm. Indocyanine Green 140-157 solute carrier organic anion transporter family member 1B3 Homo sapiens 107-114 31234288-3 2019 Both sodium taurocholate cotransporting polypeptide (NTCP) and organic-anion-transporting polypeptide 1B3 (OATP1B3) are capable of carrying indocyanine green (ICG) into the cytoplasm. Indocyanine Green 159-162 solute carrier family 10 member 1 Homo sapiens 5-51 31234288-3 2019 Both sodium taurocholate cotransporting polypeptide (NTCP) and organic-anion-transporting polypeptide 1B3 (OATP1B3) are capable of carrying indocyanine green (ICG) into the cytoplasm. Indocyanine Green 159-162 solute carrier family 10 member 1 Homo sapiens 53-57 31234288-3 2019 Both sodium taurocholate cotransporting polypeptide (NTCP) and organic-anion-transporting polypeptide 1B3 (OATP1B3) are capable of carrying indocyanine green (ICG) into the cytoplasm. Indocyanine Green 159-162 solute carrier organic anion transporter family member 1B3 Homo sapiens 63-105 31234288-3 2019 Both sodium taurocholate cotransporting polypeptide (NTCP) and organic-anion-transporting polypeptide 1B3 (OATP1B3) are capable of carrying indocyanine green (ICG) into the cytoplasm. Indocyanine Green 159-162 solute carrier organic anion transporter family member 1B3 Homo sapiens 107-114 31234288-8 2019 Both NTCP- and OATP1B3-expressing cells and xenografts had higher ICG intensities. Indocyanine Green 66-69 solute carrier family 10 member 1 Homo sapiens 5-9 31234288-8 2019 Both NTCP- and OATP1B3-expressing cells and xenografts had higher ICG intensities. Indocyanine Green 66-69 solute carrier organic anion transporter family member 1B3 Homo sapiens 15-22 31234288-9 2019 The OATP1B3-expressing xenograft has a higher ICG uptake than the NTCP-expressing xenograft. Indocyanine Green 46-49 solute carrier organic anion transporter family member 1B3 Homo sapiens 4-11 31302816-11 2019 Point estimation showed that the AL rate in the control group (no IALT) was significantly higher when compared to the ICG group (RR 0.44; Crl 0.14-0.87) and higher, but without reaching statistical significance, when compared to ALT (RR 0.53; Crl 0.21-1.30) and IOC (RR 0.49; Crl 0.10-1.80). Indocyanine Green 118-121 interleukin 31 receptor A Homo sapiens 138-141 31302816-12 2019 Indirect comparison showed that the AL rate in the ICG group was lower, when compared to both ALT (RR 0.44; Crl 0.14-0.87) and IOC (RR 0.44; Crl 0.14-0.87). Indocyanine Green 51-54 interleukin 31 receptor A Homo sapiens 108-111 31302816-12 2019 Indirect comparison showed that the AL rate in the ICG group was lower, when compared to both ALT (RR 0.44; Crl 0.14-0.87) and IOC (RR 0.44; Crl 0.14-0.87). Indocyanine Green 51-54 interleukin 31 receptor A Homo sapiens 141-144 30762108-10 2019 CONCLUSIONS: SLN mapping technique using NIR fluorescence imaging with ICG appears to be accurate method in most of the patients with cervical or endometrial carcinoma, regardless of demographic characteristics, tumor-related features and surgical approach. Indocyanine Green 71-74 sarcolipin Homo sapiens 13-16 30730539-1 2019 Importance: Assessment of melolabial flap perfusion using indocyanine green (ICG) angiography for nasal reconstruction has not been previously described. Indocyanine Green 58-75 arachidonate 5-lipoxygenase activating protein Homo sapiens 37-41 30844387-9 2019 Furthermore, we found that the Wnt/beta-catenin pathway was a downstream target of TNF-alpha and that the Wnt/beta-catenin inhibitor ICG-001 partially reversed EMT and attenuated cancer stemness. Indocyanine Green 133-136 catenin beta 1 Homo sapiens 35-47 30844387-9 2019 Furthermore, we found that the Wnt/beta-catenin pathway was a downstream target of TNF-alpha and that the Wnt/beta-catenin inhibitor ICG-001 partially reversed EMT and attenuated cancer stemness. Indocyanine Green 133-136 tumor necrosis factor Homo sapiens 83-92 30844387-9 2019 Furthermore, we found that the Wnt/beta-catenin pathway was a downstream target of TNF-alpha and that the Wnt/beta-catenin inhibitor ICG-001 partially reversed EMT and attenuated cancer stemness. Indocyanine Green 133-136 catenin beta 1 Homo sapiens 110-122 30844387-9 2019 Furthermore, we found that the Wnt/beta-catenin pathway was a downstream target of TNF-alpha and that the Wnt/beta-catenin inhibitor ICG-001 partially reversed EMT and attenuated cancer stemness. Indocyanine Green 133-136 IL2 inducible T cell kinase Homo sapiens 160-163 30730539-1 2019 Importance: Assessment of melolabial flap perfusion using indocyanine green (ICG) angiography for nasal reconstruction has not been previously described. Indocyanine Green 77-80 arachidonate 5-lipoxygenase activating protein Homo sapiens 37-41 30569106-4 2019 It was also demonstrated that ICG-001 downregulated the expression of CD44, and this effect was accompanied by restored expression of microRNA (miRNA)-150 in various NPC cell lines. Indocyanine Green 30-33 CD44 molecule (Indian blood group) Homo sapiens 70-74 31035577-9 2019 Further, we demonstrate that inhibition of beta-catenin/CBP interaction by ICG-001 decreased the amount of phosphorylated Smad3 upon TGF-beta stimulation in addition to significantly decreasing the expression levels of TGF-beta receptors, TBRII and TBRI. Indocyanine Green 75-78 catenin beta 1 Rattus norvegicus 43-55 31035577-9 2019 Further, we demonstrate that inhibition of beta-catenin/CBP interaction by ICG-001 decreased the amount of phosphorylated Smad3 upon TGF-beta stimulation in addition to significantly decreasing the expression levels of TGF-beta receptors, TBRII and TBRI. Indocyanine Green 75-78 CREB binding protein Rattus norvegicus 56-59 31035577-9 2019 Further, we demonstrate that inhibition of beta-catenin/CBP interaction by ICG-001 decreased the amount of phosphorylated Smad3 upon TGF-beta stimulation in addition to significantly decreasing the expression levels of TGF-beta receptors, TBRII and TBRI. Indocyanine Green 75-78 SMAD family member 3 Rattus norvegicus 122-127 31035577-9 2019 Further, we demonstrate that inhibition of beta-catenin/CBP interaction by ICG-001 decreased the amount of phosphorylated Smad3 upon TGF-beta stimulation in addition to significantly decreasing the expression levels of TGF-beta receptors, TBRII and TBRI. Indocyanine Green 75-78 transforming growth factor, beta 1 Rattus norvegicus 133-141 31035577-9 2019 Further, we demonstrate that inhibition of beta-catenin/CBP interaction by ICG-001 decreased the amount of phosphorylated Smad3 upon TGF-beta stimulation in addition to significantly decreasing the expression levels of TGF-beta receptors, TBRII and TBRI. Indocyanine Green 75-78 transforming growth factor, beta 1 Rattus norvegicus 219-227 30582913-4 2019 In this study, we create and characterize an endoglin (CD105) targeted imaging probe that can be used for indocyanine green (ICG) molecular angiography. Indocyanine Green 106-123 endoglin Homo sapiens 45-53 30582913-4 2019 In this study, we create and characterize an endoglin (CD105) targeted imaging probe that can be used for indocyanine green (ICG) molecular angiography. Indocyanine Green 125-128 endoglin Homo sapiens 45-53 30569106-4 2019 It was also demonstrated that ICG-001 downregulated the expression of CD44, and this effect was accompanied by restored expression of microRNA (miRNA)-150 in various NPC cell lines. Indocyanine Green 30-33 microRNA 150 Homo sapiens 134-154 30879583-0 2019 Indocyanine Green as a Beacon Light in Laparoscopy: A New Application in Transplant Surgery: A Case Report. Indocyanine Green 0-17 ubiquitin like 5 Homo sapiens 23-29 30874705-3 2019 ICG crosslinks hydroxyethyl starch (HES) and doxorubicin (DOX) conjugates (HES-SS-DOX) via noncovalent interactions, facilitating the formation of ICG@HES-SS-DOX NP. Indocyanine Green 0-3 ataxia, cerebellar, Cayman type Mus musculus 36-39 30874705-3 2019 ICG crosslinks hydroxyethyl starch (HES) and doxorubicin (DOX) conjugates (HES-SS-DOX) via noncovalent interactions, facilitating the formation of ICG@HES-SS-DOX NP. Indocyanine Green 0-3 ataxia, cerebellar, Cayman type Mus musculus 75-78 30874705-4 2019 The light triggered degradation of ICG leads to the dissociation of such NP, and the resulting HES-SS-DOX has been shown to penetrate deeper in both H22 tumor spheroids and tumor bearing mice, due to the photothermal effect of ICG. Indocyanine Green 35-38 ataxia, cerebellar, Cayman type Mus musculus 95-98 30501190-3 2019 Inspired by the indocyanine green structure, a series of polymethine dyes with both absorption and emission in the NIR-II window have been developed for NIR-II imaging, providing the feasibility to directly compare optical imaging in the NIR-IIa (1300-1400 nm) subwindow under 1064 nm excitation with that in the NIR-II window under 808 nm excitation. Indocyanine Green 16-33 ATPase, class II, type 9A Mus musculus 242-245 33405834-4 2019 A hydrophobic derivative of indocyanine green, DCC, was synthesized and entrapped into a pH-sensitive photosensitizer-core copolymer, PDCZP, to form DCC@PDCZP. Indocyanine Green 28-45 deleted in colorectal carcinoma Mus musculus 47-50 33405834-4 2019 A hydrophobic derivative of indocyanine green, DCC, was synthesized and entrapped into a pH-sensitive photosensitizer-core copolymer, PDCZP, to form DCC@PDCZP. Indocyanine Green 28-45 deleted in colorectal carcinoma Mus musculus 149-152 30475602-3 2018 In this study, small peptide TMTP1 was designed to conjugate to a near-infrared fluorescent agent ICG derivative ICG-OSu through PEG4, forming the novel probe TMTP1-PEG4-ICG. Indocyanine Green 98-101 small nuclear ribonucleoprotein N Mus musculus 129-133 30719212-0 2019 Photo-immune therapy with liposomally formulated phospholipid-conjugated indocyanine green induces specific antitumor responses with heat shock protein-70 expression in a glioblastoma model. Indocyanine Green 73-90 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 133-154 30285989-5 2019 Intraoperative use of laser-assisted indocyanine green angiography indicated excellent flap perfusion. Indocyanine Green 37-54 arachidonate 5-lipoxygenase activating protein Homo sapiens 87-91 30655145-3 2019 Intraoperative arterial hepatic flow and indocyanine green clearance (plasma clearance rate of indocyanine green [ICG-PDR]) are easily measurable variables in the intraoperative period that may be influenced by graft quality. Indocyanine Green 41-58 PDR Homo sapiens 118-121 30655145-3 2019 Intraoperative arterial hepatic flow and indocyanine green clearance (plasma clearance rate of indocyanine green [ICG-PDR]) are easily measurable variables in the intraoperative period that may be influenced by graft quality. Indocyanine Green 95-112 PDR Homo sapiens 118-121 30655145-3 2019 Intraoperative arterial hepatic flow and indocyanine green clearance (plasma clearance rate of indocyanine green [ICG-PDR]) are easily measurable variables in the intraoperative period that may be influenced by graft quality. Indocyanine Green 114-117 PDR Homo sapiens 118-121 30655145-15 2019 The group with DRI >1.70 had an ICG-PDR of 14.75 +- 6.52%/min at 60 minutes after reperfusion compared to the group with DRI <1.70, with an ICG-PDR of 16.68 +- 6.47%/min at 60 minutes after reperfusion (P = .09). Indocyanine Green 35-38 PDR Homo sapiens 39-42 30604254-5 2019 Second, Western blotting and immunofluorescence confirmed that CK19-positive HPCs incubated in differentiation medium for 7 days can differentiate into hepatocytes and that differentiated HPCs were able to take up ICG and secrete albumin and urea. Indocyanine Green 214-217 keratin 19 Homo sapiens 63-67 30267293-0 2019 Resection of Hepatic Lesions Perfused by the Cholecystic Vein Using Indocyanine Green Navigation in Patients with cT2 Gallbladder Cancer. Indocyanine Green 68-85 solute carrier family 6 member 10, pseudogene Homo sapiens 114-117 30267293-2 2019 The aim of this study is to assess the effectiveness of using an indocyanine green (ICG)-based intraoperative navigation system during hepatic resection for cT2 GBC. Indocyanine Green 65-82 solute carrier family 6 member 10, pseudogene Homo sapiens 157-160 30267293-2 2019 The aim of this study is to assess the effectiveness of using an indocyanine green (ICG)-based intraoperative navigation system during hepatic resection for cT2 GBC. Indocyanine Green 84-87 solute carrier family 6 member 10, pseudogene Homo sapiens 157-160 30216100-1 2019 PURPOSE: The aim of the present study was to evaluate the efficacy of the inverted internal limiting membrane (ILM) flap technique that involved the use of a perfluorocarbon liquid (PFCL) bubble for the selective prevention of indocyanine green (ICG) staining of the parts of the inverted flap in contact with the retinal pigment epithelium for large macular hole (MH) closure. Indocyanine Green 227-244 arachidonate 5-lipoxygenase activating protein Homo sapiens 116-120 30216100-1 2019 PURPOSE: The aim of the present study was to evaluate the efficacy of the inverted internal limiting membrane (ILM) flap technique that involved the use of a perfluorocarbon liquid (PFCL) bubble for the selective prevention of indocyanine green (ICG) staining of the parts of the inverted flap in contact with the retinal pigment epithelium for large macular hole (MH) closure. Indocyanine Green 246-249 arachidonate 5-lipoxygenase activating protein Homo sapiens 116-120 30216100-7 2019 CONCLUSIONS: The findings of this study suggest that recovery of the photoreceptor layers and, consequently, the postoperative VA are better with the inverted ILM flap technique employing PFCL-mediated selective ILM staining with ICG than with the technique employing conventional ILM staining with ICG methods for patients with large MHs. Indocyanine Green 230-233 arachidonate 5-lipoxygenase activating protein Homo sapiens 163-167 31285982-1 2019 Background The use of intraoperative fluorescence images with indocyanine green (ICG) has recently been described as an aid in decision-making during surgical procedures in adults. Indocyanine Green 63-80 activation induced cytidine deaminase Homo sapiens 121-124 31285982-1 2019 Background The use of intraoperative fluorescence images with indocyanine green (ICG) has recently been described as an aid in decision-making during surgical procedures in adults. Indocyanine Green 82-85 activation induced cytidine deaminase Homo sapiens 121-124 29501809-5 2019 INTERVENTIONS: The patient received a cervical and transcervical fundal ICG injection for para-aortic and pelvic SLN detection in the setting of a research protocol, followed by a total hysterectomy and bilateral salpingo-oophorectomy with a frozen section of the uterus as a standard approach [1]. Indocyanine Green 72-75 sarcolipin Homo sapiens 113-116 29501809-7 2019 MEASUREMENTS AND MAIN RESULTS: Dual ICG injection [2] adds the benefit of a cervical injection (that best evaluates the pelvic region [3]) to the fundal injection, with better spread to the lumboaortic pathway [4] so as not to lose the aortic drainage and aortic SLN, whose relevance is still discussed due to its low incidence of metastasis [5]. Indocyanine Green 36-39 sarcolipin Homo sapiens 263-266 30572639-5 2018 In vitro and in vivo TNBC models were used to determine the therapeutic effect of CBP inhibition via ICG-001. Indocyanine Green 101-104 CREB binding protein Homo sapiens 82-85 30475602-3 2018 In this study, small peptide TMTP1 was designed to conjugate to a near-infrared fluorescent agent ICG derivative ICG-OSu through PEG4, forming the novel probe TMTP1-PEG4-ICG. Indocyanine Green 98-101 small nuclear ribonucleoprotein N Mus musculus 165-169 30475602-3 2018 In this study, small peptide TMTP1 was designed to conjugate to a near-infrared fluorescent agent ICG derivative ICG-OSu through PEG4, forming the novel probe TMTP1-PEG4-ICG. Indocyanine Green 113-116 small nuclear ribonucleoprotein N Mus musculus 129-133 30475602-3 2018 In this study, small peptide TMTP1 was designed to conjugate to a near-infrared fluorescent agent ICG derivative ICG-OSu through PEG4, forming the novel probe TMTP1-PEG4-ICG. Indocyanine Green 113-116 small nuclear ribonucleoprotein N Mus musculus 165-169 30475602-3 2018 In this study, small peptide TMTP1 was designed to conjugate to a near-infrared fluorescent agent ICG derivative ICG-OSu through PEG4, forming the novel probe TMTP1-PEG4-ICG. Indocyanine Green 113-116 small nuclear ribonucleoprotein N Mus musculus 129-133 30475602-3 2018 In this study, small peptide TMTP1 was designed to conjugate to a near-infrared fluorescent agent ICG derivative ICG-OSu through PEG4, forming the novel probe TMTP1-PEG4-ICG. Indocyanine Green 113-116 small nuclear ribonucleoprotein N Mus musculus 165-169 30534417-6 2018 Indocyanine green angiography showed findings of AT1 in both eyes. Indocyanine Green 0-17 angiotensin II receptor type 1 Homo sapiens 49-52 30556417-5 2018 After supervised learning of our homemade dataset, our models screened out ten approved drugs, including indocyanine green and candesartan cilexetil, with IC50 values of 2.0 and 5.2 muM, respectively. Indocyanine Green 105-122 latexin Homo sapiens 182-185 30173365-13 2018 Our study confirms that combination between ICG and ERAS protocol is feasible and safe and reduces the anastomotic leakage, possibly leading to consider ICG-FA as a new ERAS item. Indocyanine Green 44-47 ES cell expressed Ras Homo sapiens 169-173 30463742-3 2018 The goal of this study is to report our experience utilizing indocyanine green (ICG) fluorescence-based technology to aid in SLNB detection in MCC. Indocyanine Green 61-78 activation induced cytidine deaminase Homo sapiens 118-121 30463742-3 2018 The goal of this study is to report our experience utilizing indocyanine green (ICG) fluorescence-based technology to aid in SLNB detection in MCC. Indocyanine Green 80-83 activation induced cytidine deaminase Homo sapiens 118-121 30173365-0 2018 Indocyanine green fluorescence angiography: a new ERAS item. Indocyanine Green 0-17 ES cell expressed Ras Homo sapiens 50-54 30346694-11 2018 We also evaluated the biodistribution and theranostic property of anti-miR-21 loaded TEV-GIONs in vivo by labeling with indocyanine green near-infrared dye. Indocyanine Green 120-137 microRNA 21a Mus musculus 71-77 29777357-2 2018 This article aims to provide an overview of the factors influencing the fluorescence intensity of fluorescence imaging with Indocyanine green, primarily focussed on NIRF guided cholangiography. Indocyanine Green 124-141 interleukin 17B Homo sapiens 165-169 32254580-0 2018 A Pd corolla-human serum albumin-indocyanine green nanocomposite for photothermal/photodynamic combination therapy of cancer. Indocyanine Green 33-50 albumin Homo sapiens 19-32 29964221-1 2018 Herein, we posit a biocompatible and pH-switchable integrated nano-delivery of CBP/ICG to the in vitro and in vivo experiments demonstrate that nanoparticles (NPs) have insignificant toxicity and good biocompatibility, and possess excellent tumor targeting efficiency as evidenced by highly efficient tumor ablation under near -infrared (NIR) illumination. Indocyanine Green 83-86 CREB binding protein Homo sapiens 79-82 30351141-5 2018 As a model system, an anti-Her2 affibody was site-specifically attached to both ICG and PpIX-stabilized nanoemulsions with encapsulated superparamagnetic iron oxide nanoparticles. Indocyanine Green 80-83 erb-b2 receptor tyrosine kinase 2 Homo sapiens 27-31 30148750-9 2018 Persistent placoid maculopathy characteristic imaging features that aid in diagnosing this rare clinical entity include the following: 1) plaque-like hypopigmented, white/yellowish foveal/perifoveal lesions on color fundus photography; 2) early hypofluorescence and late "fill-in" or staining on fluorescein angiography; 3) persistent hypocyanescence on indocyanine green angiography; and 4) choriocapillaris hyposignal on optical coherence tomography angiography. Indocyanine Green 354-371 activation induced cytidine deaminase Homo sapiens 68-71 30110551-8 2018 The recognition of overexpressed E-selectin in inflammatory tumor vascular endothelial cells led to a large accumulation of SA-Dex-OA/ICG micelles into tumor tissue, and the E-selectin upregulated on the surface of tumor cells contributed to active cellular transportation into tumor cells. Indocyanine Green 134-137 selectin E Homo sapiens 33-43 30153060-12 2018 Each fluorescing structure was confirmed to be lymphatic tissue, and NIR fluorescence imaging revealed that ICG was present in the sampled SLN. Indocyanine Green 108-111 sarcolipin Canis lupus familiaris 139-142 29948545-2 2018 This study evaluated 99mTc-GSA SPECT/CT fusion imaging for assessing liver function in patients with severely deteriorated ICG values. Indocyanine Green 123-126 GNAS complex locus Homo sapiens 27-30 30016753-1 2018 BACKGROUND: In this study, iron oxide nanoparticles (SPIONs) were synthesized and coated by GA (SG) and then SG was encapsulated by ICG (SGI). Indocyanine Green 132-135 semenogelin 1 Homo sapiens 137-140 30229774-3 2018 In this study, we conjugated a new Indocyanine Green Dye (IR820) with self-assembled polypeptide (ELP) via chemical bonding in an aqueous environment. Indocyanine Green 35-52 diazepam binding inhibitor-like 5 Mus musculus 98-101 31093167-11 2018 Comparison of the estimated difference between the ICG and the UCG showed greater decreases in HbA1c and total cholesterol in the ICG. Indocyanine Green 51-54 hemoglobin subunit alpha 1 Homo sapiens 95-99 31093167-11 2018 Comparison of the estimated difference between the ICG and the UCG showed greater decreases in HbA1c and total cholesterol in the ICG. Indocyanine Green 130-133 hemoglobin subunit alpha 1 Homo sapiens 95-99 30206265-4 2018 Targeted inhibition of Wnt/beta-catenin signaling by a small molecule, ICG-001, dose-dependently impeded the proliferation and transforming growth factor-beta1 (TGF-beta1)-mediated fibrogenic actions of LR-MSCs. Indocyanine Green 71-74 catenin beta 1 Homo sapiens 27-39 30206265-4 2018 Targeted inhibition of Wnt/beta-catenin signaling by a small molecule, ICG-001, dose-dependently impeded the proliferation and transforming growth factor-beta1 (TGF-beta1)-mediated fibrogenic actions of LR-MSCs. Indocyanine Green 71-74 transforming growth factor beta 1 Homo sapiens 127-159 30206265-4 2018 Targeted inhibition of Wnt/beta-catenin signaling by a small molecule, ICG-001, dose-dependently impeded the proliferation and transforming growth factor-beta1 (TGF-beta1)-mediated fibrogenic actions of LR-MSCs. Indocyanine Green 71-74 transforming growth factor beta 1 Homo sapiens 161-170 29744752-3 2018 The purpose of the present study is to investigate the effect of indocyanine green (ICG)-mediated PBM on osteoblast cells by measuring cell viability, proliferation, alkaline phosphatase (ALP) activity, mineralization, and gene expressions of three phenotypic osteoblast markers. Indocyanine Green 65-82 alkaline phosphatase, placental Homo sapiens 188-191 29744752-6 2018 ICG-mediated PBM did not alter cell viability but increased ALP activity and enhanced mineralization of existing osteoblasts. Indocyanine Green 0-3 alkaline phosphatase, placental Homo sapiens 60-63 29964221-3 2018 Particularly, targeted delivery of dual CBP/ICG loaded NPs provide targeted detection and transporting potential to specific receptor-expressing tumors, and then CBP interfering with DNA damage and ICG generates singlet oxygen as well as photothermal heat when irradiated with NIR for simultaneous trimodal PDT/PTT/Chemotherapy. Indocyanine Green 198-201 CREB binding protein Homo sapiens 40-43 29964221-3 2018 Particularly, targeted delivery of dual CBP/ICG loaded NPs provide targeted detection and transporting potential to specific receptor-expressing tumors, and then CBP interfering with DNA damage and ICG generates singlet oxygen as well as photothermal heat when irradiated with NIR for simultaneous trimodal PDT/PTT/Chemotherapy. Indocyanine Green 198-201 CREB binding protein Homo sapiens 162-165 29754978-7 2018 In multivariate analysis, the independent and significant predictors of cancer recurrence consisted of hepatitis C virus infection (P = .043), preoperative retention rate of indocyanine green at 15 minutes >=15% (P = .039), the presence of multiple tumors (P = .001) or microvascular invasion (P < .001), and prothrombin time-international normalized ratio to albumin ratio >=0.288 (P = .022). Indocyanine Green 174-191 coagulation factor II, thrombin Homo sapiens 315-326 30141569-2 2018 Herein, a novel RBC membrane biomimetic combination therapeutic system with tumor targeting ability is constructed by embedding bovine serum albumin (BSA) encapsulated with 1,2-diaminocyclohexane-platinum (II) (DACHPt) and indocyanine green (ICG) in the targeting peptide-modified erythrocyte membrane (R-RBC@BPtI) for enhancing tumor internalization and synergetic chemophototherapy. Indocyanine Green 223-240 albumin Homo sapiens 135-148 30141569-2 2018 Herein, a novel RBC membrane biomimetic combination therapeutic system with tumor targeting ability is constructed by embedding bovine serum albumin (BSA) encapsulated with 1,2-diaminocyclohexane-platinum (II) (DACHPt) and indocyanine green (ICG) in the targeting peptide-modified erythrocyte membrane (R-RBC@BPtI) for enhancing tumor internalization and synergetic chemophototherapy. Indocyanine Green 242-245 albumin Homo sapiens 135-148 30525075-2 2018 In a further previous report, we identified IC-2, a newly synthesized derivative of the Wnt/beta-catenin signaling inhibitor ICG-001, as a potent inducer of hepatic differentiation of BM-MSCs. Indocyanine Green 125-128 dynein cytoplasmic 1 intermediate chain 2 Homo sapiens 44-48 30148784-8 2018 Indocyanine green angiography revealed three interesting perfusion patterns of pure skin perforator flap: a radial diffusion pattern, direct linking vessels in the intradermal layer, and intradermal arteriovenous shunts. Indocyanine Green 0-17 arachidonate 5-lipoxygenase activating protein Homo sapiens 100-104 30139028-17 2018 Conclusion: The newly constructed Fe(3)O(4)-trastuzumab-ICG NPs have the potential to act as a multifunctional imaging agent and a powerful tool for photothermal therapy for HER-2 positive breast cancer. Indocyanine Green 56-59 erb-b2 receptor tyrosine kinase 2 Homo sapiens 174-179 29712688-0 2018 Intraoperative Resection Guidance with Photoacoustic and Fluorescence Molecular Imaging Using an Anti-B7-H3 Antibody-Indocyanine Green Dual Contrast Agent. Indocyanine Green 117-134 CD276 antigen Mus musculus 102-107 30075015-3 2018 ICG-001 is a small molecule Wnt inhibitor that specifically targets the coactivator CREB binding protein (CBP)/beta-catenin-mediated signalling. Indocyanine Green 0-3 Wnt family member 2 Rattus norvegicus 28-31 30075015-3 2018 ICG-001 is a small molecule Wnt inhibitor that specifically targets the coactivator CREB binding protein (CBP)/beta-catenin-mediated signalling. Indocyanine Green 0-3 CREB binding protein Rattus norvegicus 84-104 30075015-3 2018 ICG-001 is a small molecule Wnt inhibitor that specifically targets the coactivator CREB binding protein (CBP)/beta-catenin-mediated signalling. Indocyanine Green 0-3 CREB binding protein Rattus norvegicus 106-109 30075015-3 2018 ICG-001 is a small molecule Wnt inhibitor that specifically targets the coactivator CREB binding protein (CBP)/beta-catenin-mediated signalling. Indocyanine Green 0-3 catenin beta 1 Rattus norvegicus 111-123 30029671-13 2018 CONCLUSIONS: Collectively, our results identify beta-catenin/CBP interaction as a novel target for anti-HNSCC therapy and provide evidence that derivatives of ICG-001 with enhanced inhibitory activity may serve as an effective strategy to interfere with aggressive features of HNSCC. Indocyanine Green 159-162 catenin beta 1 Homo sapiens 48-60 31047533-0 2018 Indocyanine Green Dye Filling Time for Polypoidal Lesions in Polypoidal Choroidal Vasculopathy Affects the Visibility of the Lesions on OCT Angiography. Indocyanine Green 0-17 plexin A2 Homo sapiens 136-139 30029671-13 2018 CONCLUSIONS: Collectively, our results identify beta-catenin/CBP interaction as a novel target for anti-HNSCC therapy and provide evidence that derivatives of ICG-001 with enhanced inhibitory activity may serve as an effective strategy to interfere with aggressive features of HNSCC. Indocyanine Green 159-162 CREB binding protein Homo sapiens 61-64 30029671-6 2018 METHODS: We utilized a combination of computational and experimental profiling approaches to examine the effects of blocking the interaction between beta-catenin and cAMP-responsive element binding (CREB)-binding protein (CBP) using the small molecule inhibitor ICG-001. Indocyanine Green 262-265 catenin beta 1 Homo sapiens 149-161 30029671-6 2018 METHODS: We utilized a combination of computational and experimental profiling approaches to examine the effects of blocking the interaction between beta-catenin and cAMP-responsive element binding (CREB)-binding protein (CBP) using the small molecule inhibitor ICG-001. Indocyanine Green 262-265 CREB binding protein Homo sapiens 222-225 29671411-1 2018 A novel core-shell type nanoparticle (CSNP) was designed here to target co-delivery of doxorubicin (DOX) and photosensitizer indocyanine green (ICG) to tumor sites by the aid of NIR induced photothermal conversion effect for the purpose of synergistic chemo-photothermal cancer therapy. Indocyanine Green 125-142 NOC2 like nucleolar associated transcriptional repressor Homo sapiens 178-181 30029671-12 2018 Significantly, interrogation of the ICG-001 inhibition-associated gene expression signature in the TCGA OSCC human cohort indicated that the targeted beta-catenin/CBP transcriptional activity tracked with tumor status, advanced tumor grade, and poor overall patient survival. Indocyanine Green 36-39 catenin beta 1 Homo sapiens 150-162 30029671-12 2018 Significantly, interrogation of the ICG-001 inhibition-associated gene expression signature in the TCGA OSCC human cohort indicated that the targeted beta-catenin/CBP transcriptional activity tracked with tumor status, advanced tumor grade, and poor overall patient survival. Indocyanine Green 36-39 CREB binding protein Homo sapiens 163-166 29671411-1 2018 A novel core-shell type nanoparticle (CSNP) was designed here to target co-delivery of doxorubicin (DOX) and photosensitizer indocyanine green (ICG) to tumor sites by the aid of NIR induced photothermal conversion effect for the purpose of synergistic chemo-photothermal cancer therapy. Indocyanine Green 144-147 NOC2 like nucleolar associated transcriptional repressor Homo sapiens 178-181 29860678-11 2018 Significant correlations were also observed between the LSR and indocyanine green retention rate at 15 min (r = - 0.601, p < 0.001), between the LSR and liver fibrosis stage (r = - 0.556, p < 0.001), and between the LSR and liver steatosis grade (r = - 0.396, p < 0.001). Indocyanine Green 64-81 lipolysis stimulated lipoprotein receptor Homo sapiens 56-59 29986466-7 2018 Correspondingly, inhibition of Wnt/beta-catenin pathway by ICG-001, a specific Wnt/&-catenin inhibitor, preferentially reduced proliferation and invasion of trastuzumab-resistant cells and reversed EMT. Indocyanine Green 59-62 catenin beta 1 Homo sapiens 35-47 29980962-13 2018 Changes in ICG-PDR were concomitant with changes in IAP (r = - 0.602) and APP (r = 0.576). Indocyanine Green 11-14 alkaline phosphatase, intestinal Homo sapiens 52-55 29481294-7 2018 However, for both assays, significant differences were eliminated in the presence of the beta-catenin inhibitor ICG-001. Indocyanine Green 112-115 catenin (cadherin associated protein), beta 1 Mus musculus 89-101 29989005-6 2018 Inhibition of CREB binding protein (CBP) by the specific inhibitor ICG-001 not only abrogated the LPS-induced radioresistance but even led to an increase in radiosensitivity. Indocyanine Green 67-70 CREB binding protein Homo sapiens 14-34 29989005-6 2018 Inhibition of CREB binding protein (CBP) by the specific inhibitor ICG-001 not only abrogated the LPS-induced radioresistance but even led to an increase in radiosensitivity. Indocyanine Green 67-70 CREB binding protein Homo sapiens 36-39 30026877-4 2018 Methods: The ICG/SRT@HSA-pept NMs were formulated to contain payloads of the near-infrared (NIR) fluorescent dye indocyanine green (ICG) and the sirtuin 1 (Sirt1) activator SRT1720, and modified with a peptide moiety targeting osteopontin (OPN). Indocyanine Green 13-16 sirtuin 1 Mus musculus 145-154 30026877-4 2018 Methods: The ICG/SRT@HSA-pept NMs were formulated to contain payloads of the near-infrared (NIR) fluorescent dye indocyanine green (ICG) and the sirtuin 1 (Sirt1) activator SRT1720, and modified with a peptide moiety targeting osteopontin (OPN). Indocyanine Green 13-16 sirtuin 1 Mus musculus 156-161 30026877-4 2018 Methods: The ICG/SRT@HSA-pept NMs were formulated to contain payloads of the near-infrared (NIR) fluorescent dye indocyanine green (ICG) and the sirtuin 1 (Sirt1) activator SRT1720, and modified with a peptide moiety targeting osteopontin (OPN). Indocyanine Green 13-16 secreted phosphoprotein 1 Mus musculus 227-238 30026877-4 2018 Methods: The ICG/SRT@HSA-pept NMs were formulated to contain payloads of the near-infrared (NIR) fluorescent dye indocyanine green (ICG) and the sirtuin 1 (Sirt1) activator SRT1720, and modified with a peptide moiety targeting osteopontin (OPN). Indocyanine Green 13-16 secreted phosphoprotein 1 Mus musculus 240-243 29363326-8 2018 Treatment with a beta-catenin inhibitor (ICG-001) in mice with AdTGF-beta-induced peritoneal fibrosis resulted in attenuation of peritoneal angiogenesis and reduced vascular endothelial growth factor. Indocyanine Green 41-44 catenin (cadherin associated protein), beta 1 Mus musculus 17-29 29984013-5 2018 We reported our experience of ICG-fluorescence-guided liver resection of metastasis located at VIII Couinaud"s segment from colon squamous cell carcinoma of a 74-year-old male patient. Indocyanine Green 30-33 cytochrome c oxidase subunit 8A Homo sapiens 95-99 29548950-8 2018 A clip repositioning rate of 17.1% was revealed after intraoperative 3D-VR imaging and initial indocyanine green-video angiography. Indocyanine Green 95-112 CAP-Gly domain containing linker protein 2 Homo sapiens 2-6 29984921-1 2018 OBJECTIVE: This study aims to prepare docetaxel (DOC)-loaded multifunctional nanoparticles containing indocyanine green (ICG) and perfluorohexane (PFH) as targeted drug delivery system, which is supplemented with stromal cellderived factor-1 (SDF-1), and characterize their properties. Indocyanine Green 121-124 C-X-C motif chemokine ligand 12 Homo sapiens 213-241 29984921-1 2018 OBJECTIVE: This study aims to prepare docetaxel (DOC)-loaded multifunctional nanoparticles containing indocyanine green (ICG) and perfluorohexane (PFH) as targeted drug delivery system, which is supplemented with stromal cellderived factor-1 (SDF-1), and characterize their properties. Indocyanine Green 121-124 C-X-C motif chemokine ligand 12 Homo sapiens 243-248 29341436-2 2018 Herein, for monitoring COX-2, we synthesize a specific COX-2 probe celecoxib-MPA probe (CMP), based on celecoxib and a water-soluble near-infrared dye dye ICG-Der-02 (MPA). Indocyanine Green 155-158 prostaglandin-endoperoxide synthase 2 Homo sapiens 55-60 29408424-2 2018 Here, we built a light sensitive liposome (Her2-I&D-LSL) which was formed by a special phospholipid (PLsPC) and a hydrophobically modified photosensitizer (ICG-ODA). Indocyanine Green 160-163 erb-b2 receptor tyrosine kinase 2 Homo sapiens 43-47 29856819-10 2018 Thus, activatable fluorescence imaging using the Pan-ICG conjugate detected EGFR-positive mediastinal lymph node metastases with high specificity. Indocyanine Green 53-56 epidermal growth factor receptor Mus musculus 76-80 29595852-3 2018 Herein, we fabricated doxorubicin hydrochloride (DOX)- and indocyanine green (ICG)-loaded microneedle (MN) patches (PVP@DOX/MSN@ICG) using a two-step casting process. Indocyanine Green 59-76 moesin Homo sapiens 124-127 29783745-3 2018 In this work, we developed a novel photothermal and photodynamic therapeutic nanoplatform for treatment of cancer cells overexpressing integrin alphavbeta3 through the coating of polydopamine (PDA) on indocyanine green (ICG)-loaded laponite (LAP) and then further conjugating polyethylene glycol-arginine-glycine-aspartic acid (PEG-RGD) as targeted agents on the surface. Indocyanine Green 201-218 integrin subunit alpha V Homo sapiens 135-155 29783745-3 2018 In this work, we developed a novel photothermal and photodynamic therapeutic nanoplatform for treatment of cancer cells overexpressing integrin alphavbeta3 through the coating of polydopamine (PDA) on indocyanine green (ICG)-loaded laponite (LAP) and then further conjugating polyethylene glycol-arginine-glycine-aspartic acid (PEG-RGD) as targeted agents on the surface. Indocyanine Green 220-223 integrin subunit alpha V Homo sapiens 135-155 29500978-7 2018 More importantly, LIP-PFOB-ICG inhibited MDA-MB-231 tumor growth completely via intravenous injection through enhanced PDT&PTT synergistic therapy due to the excellent oxygen carrying ability of PFOB, which effectively attenuated tumor hypoxia, improved the efficiency of collisional energy transfer between ICG and oxygen and reduced the expression of heat shock protein (HSP). Indocyanine Green 27-30 heat shock protein 90 beta family member 2, pseudogene Homo sapiens 357-375 29500978-7 2018 More importantly, LIP-PFOB-ICG inhibited MDA-MB-231 tumor growth completely via intravenous injection through enhanced PDT&PTT synergistic therapy due to the excellent oxygen carrying ability of PFOB, which effectively attenuated tumor hypoxia, improved the efficiency of collisional energy transfer between ICG and oxygen and reduced the expression of heat shock protein (HSP). Indocyanine Green 27-30 heat shock protein 90 beta family member 2, pseudogene Homo sapiens 377-380 29520973-16 2018 The tumor tissue preference of ICG in the present model can be attributed to the enhanced vascular leakage of ICG involving inflammatory mediators, such as COX-2 and inducible nitric oxide synthase, in conjunction with increased tumor vascularity. Indocyanine Green 31-34 cytochrome c oxidase II, mitochondrial Mus musculus 156-161 29520973-16 2018 The tumor tissue preference of ICG in the present model can be attributed to the enhanced vascular leakage of ICG involving inflammatory mediators, such as COX-2 and inducible nitric oxide synthase, in conjunction with increased tumor vascularity. Indocyanine Green 31-34 nitric oxide synthase 2, inducible Mus musculus 166-197 29520973-16 2018 The tumor tissue preference of ICG in the present model can be attributed to the enhanced vascular leakage of ICG involving inflammatory mediators, such as COX-2 and inducible nitric oxide synthase, in conjunction with increased tumor vascularity. Indocyanine Green 110-113 cytochrome c oxidase II, mitochondrial Mus musculus 156-161 29520973-16 2018 The tumor tissue preference of ICG in the present model can be attributed to the enhanced vascular leakage of ICG involving inflammatory mediators, such as COX-2 and inducible nitric oxide synthase, in conjunction with increased tumor vascularity. Indocyanine Green 110-113 nitric oxide synthase 2, inducible Mus musculus 166-197 29701711-0 2018 Anti-EGFR Indocyanine Green-Mitomycin C-Loaded Perfluorocarbon Double Nanoemulsion: A Novel Nanostructure for Targeted Photochemotherapy of Bladder Cancer Cells. Indocyanine Green 10-27 epidermal growth factor receptor Homo sapiens 5-9 29499919-9 2018 Furthermore, Wnt1, beta-Catenin, c-Myc and Cyclin D1 were significantly increased after US irradiation (all p <0.05), and the enhancements of c-Myc and Cyclin D1 could be obviously impaired by the inhibitor ICG-001 (p <0.05, p <0.05), in accordance with decreased ALB and CK18 expression and glycogen content (all p <0.05). Indocyanine Green 210-213 MYC proto-oncogene, bHLH transcription factor Homo sapiens 145-150 29499919-9 2018 Furthermore, Wnt1, beta-Catenin, c-Myc and Cyclin D1 were significantly increased after US irradiation (all p <0.05), and the enhancements of c-Myc and Cyclin D1 could be obviously impaired by the inhibitor ICG-001 (p <0.05, p <0.05), in accordance with decreased ALB and CK18 expression and glycogen content (all p <0.05). Indocyanine Green 210-213 cyclin D1 Homo sapiens 155-164 29703178-9 2018 SOX9 expression correlated significantly with ECG (96% SOX9 high in ECG patients vs. 79% SOX9 high in patients with ICG; p = 0.002). Indocyanine Green 116-119 SRY-box transcription factor 9 Homo sapiens 0-4 29701711-2 2018 In this study, we aim to manufacture anti-EGFR indocyanine green (ICG) mitomycin C (MMC) encapsulated perfluorocarbon double nanoemulsions (EIMPDNEs), and explore their photochemotherapeutic efficacy on EGFR-expressing bladder cancer cells in vitro. Indocyanine Green 47-64 epidermal growth factor receptor Homo sapiens 42-46 29701711-2 2018 In this study, we aim to manufacture anti-EGFR indocyanine green (ICG) mitomycin C (MMC) encapsulated perfluorocarbon double nanoemulsions (EIMPDNEs), and explore their photochemotherapeutic efficacy on EGFR-expressing bladder cancer cells in vitro. Indocyanine Green 47-64 epidermal growth factor receptor Homo sapiens 203-207 29701711-2 2018 In this study, we aim to manufacture anti-EGFR indocyanine green (ICG) mitomycin C (MMC) encapsulated perfluorocarbon double nanoemulsions (EIMPDNEs), and explore their photochemotherapeutic efficacy on EGFR-expressing bladder cancer cells in vitro. Indocyanine Green 66-69 epidermal growth factor receptor Homo sapiens 42-46 29701711-2 2018 In this study, we aim to manufacture anti-EGFR indocyanine green (ICG) mitomycin C (MMC) encapsulated perfluorocarbon double nanoemulsions (EIMPDNEs), and explore their photochemotherapeutic efficacy on EGFR-expressing bladder cancer cells in vitro. Indocyanine Green 66-69 epidermal growth factor receptor Homo sapiens 203-207 29596326-3 2018 AIM/METHODS: To investigate Wnt-mediated carcinogenesis in PDAC, we have used the specific small molecule CBP/beta-catenin antagonist, ICG-001, which our lab identified and has extensively characterized, to examine its effects in human pancreatic cancer cells and in both an orthotopic mouse model and a human patient-derived xenograft (PDX) model of PDAC. Indocyanine Green 135-138 CREB binding protein Homo sapiens 106-109 29806309-17 2018 Conclusion: ICG-based fluorescent angiography can reveal the perfusion of the flap in operation instantly and accurately. Indocyanine Green 12-15 arachidonate 5-lipoxygenase activating protein Homo sapiens 78-82 29408311-2 2018 In this work, a carrier-free nanodrug was developed by co-assembly of the anti-cancer agent ursolic acid (UA), an asialoglycoprotein receptor (ASGPR), which can recognize the target molecule lactobionic acid (LA), and the near-infrared (NIR) probe dye indocyanine green (ICG) to form UA-LA-ICG NPs by a simple and green self-assembly approach. Indocyanine Green 252-269 asialoglycoprotein receptor 1 Homo sapiens 143-148 29408311-2 2018 In this work, a carrier-free nanodrug was developed by co-assembly of the anti-cancer agent ursolic acid (UA), an asialoglycoprotein receptor (ASGPR), which can recognize the target molecule lactobionic acid (LA), and the near-infrared (NIR) probe dye indocyanine green (ICG) to form UA-LA-ICG NPs by a simple and green self-assembly approach. Indocyanine Green 271-274 asialoglycoprotein receptor 1 Homo sapiens 143-148 29087049-4 2018 At the time of reperfusion, indocyanine green-based in vivo imaging showed that CD47mAb-treated organs had greater and more uniform reperfusion. Indocyanine Green 28-45 CD47 molecule Homo sapiens 80-84 29214646-0 2018 Endoscopic sentinel lymph node biopsy using indocyanine green-neomannosyl human serum albumin. Indocyanine Green 44-61 albumin Oryctolagus cuniculus 80-93 29214646-1 2018 OBJECTIVE: The aim of this study was to determine the possibility of endoscopic sentinel lymph node biopsy of the head and neck region using indocyanine green-neomannosyl human serum albumin (ICG:MSA) and a custom-made intraoperative color-and-fluorescence-merged imaging system (ICFIS). Indocyanine Green 141-158 albumin Oryctolagus cuniculus 177-190 29596326-3 2018 AIM/METHODS: To investigate Wnt-mediated carcinogenesis in PDAC, we have used the specific small molecule CBP/beta-catenin antagonist, ICG-001, which our lab identified and has extensively characterized, to examine its effects in human pancreatic cancer cells and in both an orthotopic mouse model and a human patient-derived xenograft (PDX) model of PDAC. Indocyanine Green 135-138 catenin beta 1 Homo sapiens 110-122 29596326-4 2018 RESULTS/CONCLUSION: We report for the first time that K-Ras activation increases the CBP/beta-catenin interaction in pancreatic cancer; and that ICG-001 specific antagonism of the CBP/beta-catenin interaction sensitizes pancreatic cancer cells and tumors to gemcitabine treatment. Indocyanine Green 145-148 CREB binding protein Homo sapiens 85-88 29596326-4 2018 RESULTS/CONCLUSION: We report for the first time that K-Ras activation increases the CBP/beta-catenin interaction in pancreatic cancer; and that ICG-001 specific antagonism of the CBP/beta-catenin interaction sensitizes pancreatic cancer cells and tumors to gemcitabine treatment. Indocyanine Green 145-148 CREB binding protein Homo sapiens 180-183 29596326-4 2018 RESULTS/CONCLUSION: We report for the first time that K-Ras activation increases the CBP/beta-catenin interaction in pancreatic cancer; and that ICG-001 specific antagonism of the CBP/beta-catenin interaction sensitizes pancreatic cancer cells and tumors to gemcitabine treatment. Indocyanine Green 145-148 catenin beta 1 Homo sapiens 184-196 28945324-2 2018 Recently, metallic nanoparticles and dyes, such as gold nanoparticles, methylene blue, and indocyanine green, have been used as contrast agents of OR-PAM. Indocyanine Green 91-108 peptidylglycine alpha-amidating monooxygenase Mus musculus 150-153 29615837-4 2018 Results: The targeted fluorescence probes (indocyanine green-liposomes decorated with iRGD peptide [iLPs]) was successfully prepared. Indocyanine Green 43-60 interferon gamma inducible protein 47 Mus musculus 86-90 29217140-0 2018 Inhibition of canonical WNT signaling pathway by beta-catenin/CBP inhibitor ICG-001 ameliorates liver fibrosis in vivo through suppression of stromal CXCL12. Indocyanine Green 76-79 catenin beta 1 Homo sapiens 49-61 29217140-0 2018 Inhibition of canonical WNT signaling pathway by beta-catenin/CBP inhibitor ICG-001 ameliorates liver fibrosis in vivo through suppression of stromal CXCL12. Indocyanine Green 76-79 CREB binding protein Homo sapiens 62-65 29217140-0 2018 Inhibition of canonical WNT signaling pathway by beta-catenin/CBP inhibitor ICG-001 ameliorates liver fibrosis in vivo through suppression of stromal CXCL12. Indocyanine Green 76-79 C-X-C motif chemokine ligand 12 Homo sapiens 150-156 29268142-2 2018 Indocyanine green (ICG) was loaded into AuNR@MSN and end-capped with beta-cyclodextrin (beta-CD). Indocyanine Green 0-17 moesin Homo sapiens 45-48 29268142-2 2018 Indocyanine green (ICG) was loaded into AuNR@MSN and end-capped with beta-cyclodextrin (beta-CD). Indocyanine Green 19-22 moesin Homo sapiens 45-48 29758552-11 2018 Moreover, the expression of S100A4 decreased after ICG-001 inhibited beta-catenin signal pathway. Indocyanine Green 51-54 S100 calcium binding protein A4 Mus musculus 28-34 29224185-8 2018 However, ICG-001, the beta-catenin selective inhibitor, reversed the positive effects of GSK-3beta inhibition. Indocyanine Green 9-12 catenin beta 1 Rattus norvegicus 22-34 29224185-8 2018 However, ICG-001, the beta-catenin selective inhibitor, reversed the positive effects of GSK-3beta inhibition. Indocyanine Green 9-12 glycogen synthase kinase 3 beta Rattus norvegicus 89-98 29721409-3 2018 Here, glutathione (GSH)-activated light-up peptide-polysaccharide-inter-polyelectrolyte nanocomplexes are established through self-assembly of carboxymethyl dextran with disulfide-bridged ("S-S") oligoarginine peptide (S-Arg4), in which microRNA-34a (miR-34a) and indocyanine green (ICG) are simultaneously embedded and the nanocomplexes are subsequently stabilized by intermolecular cross-linking. Indocyanine Green 264-281 microRNA 34a Homo sapiens 237-249 29721409-3 2018 Here, glutathione (GSH)-activated light-up peptide-polysaccharide-inter-polyelectrolyte nanocomplexes are established through self-assembly of carboxymethyl dextran with disulfide-bridged ("S-S") oligoarginine peptide (S-Arg4), in which microRNA-34a (miR-34a) and indocyanine green (ICG) are simultaneously embedded and the nanocomplexes are subsequently stabilized by intermolecular cross-linking. Indocyanine Green 264-281 microRNA 34a Homo sapiens 251-258 29721409-3 2018 Here, glutathione (GSH)-activated light-up peptide-polysaccharide-inter-polyelectrolyte nanocomplexes are established through self-assembly of carboxymethyl dextran with disulfide-bridged ("S-S") oligoarginine peptide (S-Arg4), in which microRNA-34a (miR-34a) and indocyanine green (ICG) are simultaneously embedded and the nanocomplexes are subsequently stabilized by intermolecular cross-linking. Indocyanine Green 283-286 microRNA 34a Homo sapiens 237-249 29721409-3 2018 Here, glutathione (GSH)-activated light-up peptide-polysaccharide-inter-polyelectrolyte nanocomplexes are established through self-assembly of carboxymethyl dextran with disulfide-bridged ("S-S") oligoarginine peptide (S-Arg4), in which microRNA-34a (miR-34a) and indocyanine green (ICG) are simultaneously embedded and the nanocomplexes are subsequently stabilized by intermolecular cross-linking. Indocyanine Green 283-286 microRNA 34a Homo sapiens 251-258 29758552-11 2018 Moreover, the expression of S100A4 decreased after ICG-001 inhibited beta-catenin signal pathway. Indocyanine Green 51-54 catenin (cadherin associated protein), beta 1 Mus musculus 69-81 29332125-2 2018 In this study, we investigated the sensitivity of UM cells to ICG-001, a small molecule reported to suppress the Wnt/beta-catenin-mediated transcriptional program. Indocyanine Green 62-65 catenin beta 1 Homo sapiens 117-129 28933312-4 2018 It has been demonstrated previously that drug resistant CML LIC/LSC can be safely eliminated both in vitro and in vivo via disruption of the CBP/catenin interaction, utilizing the highly biochemically selective small molecule CBP/catenin antagonist ICG- 001. Indocyanine Green 249-252 CREB binding protein Homo sapiens 141-144 28933312-4 2018 It has been demonstrated previously that drug resistant CML LIC/LSC can be safely eliminated both in vitro and in vivo via disruption of the CBP/catenin interaction, utilizing the highly biochemically selective small molecule CBP/catenin antagonist ICG- 001. Indocyanine Green 249-252 CREB binding protein Homo sapiens 226-229 28933312-8 2018 In Long-Term Culture Initiating Cell assay (LTC-IC, a surrogate assay for long term repopulating stem cells), our results suggest that the CBP/catenin antagonist ICG- 001 sensitizes LIC/LSC to IM treatment by forced differentiative elimination of the CML LIC/LSC population. Indocyanine Green 162-165 CREB binding protein Homo sapiens 139-142 28933312-11 2018 CBP/catenin antagonist ICG-001 facilitates IM function in eliminating these cells. Indocyanine Green 23-26 CREB binding protein Homo sapiens 0-3 29332125-8 2018 Strikingly, ICG-001 suppressed the expression of genes associated with UM aggressiveness, including CDH1, CITED1, EMP1, EMP3, SDCBP, and SPARC. Indocyanine Green 12-15 cadherin 1 Homo sapiens 100-104 29332125-8 2018 Strikingly, ICG-001 suppressed the expression of genes associated with UM aggressiveness, including CDH1, CITED1, EMP1, EMP3, SDCBP, and SPARC. Indocyanine Green 12-15 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 Homo sapiens 106-112 29332125-8 2018 Strikingly, ICG-001 suppressed the expression of genes associated with UM aggressiveness, including CDH1, CITED1, EMP1, EMP3, SDCBP, and SPARC. Indocyanine Green 12-15 epithelial membrane protein 1 Homo sapiens 114-118 29332125-8 2018 Strikingly, ICG-001 suppressed the expression of genes associated with UM aggressiveness, including CDH1, CITED1, EMP1, EMP3, SDCBP, and SPARC. Indocyanine Green 12-15 epithelial membrane protein 3 Homo sapiens 120-124 29332125-8 2018 Strikingly, ICG-001 suppressed the expression of genes associated with UM aggressiveness, including CDH1, CITED1, EMP1, EMP3, SDCBP, and SPARC. Indocyanine Green 12-15 syndecan binding protein Homo sapiens 126-131 29332125-8 2018 Strikingly, ICG-001 suppressed the expression of genes associated with UM aggressiveness, including CDH1, CITED1, EMP1, EMP3, SDCBP, and SPARC. Indocyanine Green 12-15 secreted protein acidic and cysteine rich Homo sapiens 137-142 29079533-12 2018 Indocyanine green (ICG)-labeled PASR8-NMU (i.n.) Indocyanine Green 0-17 neuromedin U Mus musculus 38-41 29079533-12 2018 Indocyanine green (ICG)-labeled PASR8-NMU (i.n.) Indocyanine Green 19-22 neuromedin U Mus musculus 38-41 29087183-5 2017 In addition, the near-infrared (NIR) absorbing phototherapeutic agent [indocyanine green (ICG)] was loaded into the Au@BSA-Gd nanoparticles because of their unique, hollow, and porous structures, thus possessing photodynamic/photothermal property and near-infrared fluorescence (NIRF)/PA imaging capability. Indocyanine Green 71-88 interleukin 17B Homo sapiens 279-283 30393697-0 2018 Highly Sensitive MoS2-Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site. Indocyanine Green 22-39 mago homolog, exon junction complex core component Mus musculus 17-21 30393697-3 2018 Herein, we report a MoS2-ICG hybrid with indocyanine green (ICG) conjugated to the surface of MoS2 nanosheets. Indocyanine Green 25-28 mago homolog, exon junction complex core component Mus musculus 20-24 30393697-3 2018 Herein, we report a MoS2-ICG hybrid with indocyanine green (ICG) conjugated to the surface of MoS2 nanosheets. Indocyanine Green 25-28 mago homolog, exon junction complex core component Mus musculus 94-98 30393697-3 2018 Herein, we report a MoS2-ICG hybrid with indocyanine green (ICG) conjugated to the surface of MoS2 nanosheets. Indocyanine Green 41-58 mago homolog, exon junction complex core component Mus musculus 20-24 30393697-3 2018 Herein, we report a MoS2-ICG hybrid with indocyanine green (ICG) conjugated to the surface of MoS2 nanosheets. Indocyanine Green 41-58 mago homolog, exon junction complex core component Mus musculus 94-98 30393697-3 2018 Herein, we report a MoS2-ICG hybrid with indocyanine green (ICG) conjugated to the surface of MoS2 nanosheets. Indocyanine Green 60-63 mago homolog, exon junction complex core component Mus musculus 20-24 30393697-3 2018 Herein, we report a MoS2-ICG hybrid with indocyanine green (ICG) conjugated to the surface of MoS2 nanosheets. Indocyanine Green 60-63 mago homolog, exon junction complex core component Mus musculus 94-98 29568455-3 2017 The obtained PDA/mCaP H-JNPs were further selectively functionalized with indocyanine green (ICG) and methoxy-poly(ethylene glycol)thiol (PEG-SH) on PDA domains to achieve a superior photoacoustic (PA) imaging capability and stability, while the other mCaP sides with hollow cavities served as storage spaces and passages for the anti-cancer drug, doxorubicin (DOX). Indocyanine Green 74-91 non-SMC condensin I complex, subunit H Mus musculus 17-23 29568455-3 2017 The obtained PDA/mCaP H-JNPs were further selectively functionalized with indocyanine green (ICG) and methoxy-poly(ethylene glycol)thiol (PEG-SH) on PDA domains to achieve a superior photoacoustic (PA) imaging capability and stability, while the other mCaP sides with hollow cavities served as storage spaces and passages for the anti-cancer drug, doxorubicin (DOX). Indocyanine Green 93-96 non-SMC condensin I complex, subunit H Mus musculus 17-23 29087183-5 2017 In addition, the near-infrared (NIR) absorbing phototherapeutic agent [indocyanine green (ICG)] was loaded into the Au@BSA-Gd nanoparticles because of their unique, hollow, and porous structures, thus possessing photodynamic/photothermal property and near-infrared fluorescence (NIRF)/PA imaging capability. Indocyanine Green 90-93 interleukin 17B Homo sapiens 279-283 29039909-0 2017 Indocyanine Green-holo-Transferrin Nanoassemblies for Tumor-Targeted Dual-Modal Imaging and Photothermal Therapy of Glioma. Indocyanine Green 0-17 transferrin Homo sapiens 23-34 29042529-0 2017 Value of Preoperative Indocyanine Green Clearance Test for Predicting Post-Hepatectomy Liver Failure in Noncirrhotic Patients. Indocyanine Green 22-39 solute carrier family 35 member G1 Homo sapiens 70-74 29134135-4 2017 The acquired OCT volumes were centered on the branching vascular network (BVN) and polyps as determined by indocyanine-green angiography (ICGA). Indocyanine Green 107-124 plexin A2 Homo sapiens 13-16 28861697-1 2017 PURPOSE: The purpose of our study was to describe the feature of acute non-arteritic or arteritic anterior ischemic optic neuropathy (NA-AION and A-AION) using optical coherence tomography angiography (OCT-A) and to compare it with fluorescein angiography (FA) and indocyanine green angiography (ICGA). Indocyanine Green 265-282 plexin A2 Homo sapiens 202-205 29290987-0 2017 ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect. Indocyanine Green 0-3 collapsin response mediator protein 1 Homo sapiens 16-20 29290987-6 2017 We utilized this to undertake focused compound library screening and identified potent modulators that affected DRP1 activity including ICG-001, which is described as WNT/beta-catenin signaling inhibitor. Indocyanine Green 136-139 collapsin response mediator protein 1 Homo sapiens 112-116 29290987-6 2017 We utilized this to undertake focused compound library screening and identified potent modulators that affected DRP1 activity including ICG-001, which is described as WNT/beta-catenin signaling inhibitor. Indocyanine Green 136-139 catenin beta 1 Homo sapiens 171-183 28492965-4 2017 The aim of this study was to evaluate the role of ICG-99mTc-nanocolloid in SLN detection in patients with cervical cancer. Indocyanine Green 50-53 sarcolipin Homo sapiens 75-78 28833643-4 2017 With NCPs consisting of Mn2+/indocyanine green (ICG) as the example, Mn-ICG@pHis-PEG display efficient pH-responsive tumor retention after systemic administration and then load Gambogic acid (GA), a natural inhibitor of heat-shock protein 90 (Hsp90) that plays an essential role for cells to resist heating-induced damage. Indocyanine Green 29-46 heat shock protein 90 alpha family class A member 1 Homo sapiens 220-241 28833643-4 2017 With NCPs consisting of Mn2+/indocyanine green (ICG) as the example, Mn-ICG@pHis-PEG display efficient pH-responsive tumor retention after systemic administration and then load Gambogic acid (GA), a natural inhibitor of heat-shock protein 90 (Hsp90) that plays an essential role for cells to resist heating-induced damage. Indocyanine Green 29-46 heat shock protein 90 alpha family class A member 1 Homo sapiens 243-248 28833643-4 2017 With NCPs consisting of Mn2+/indocyanine green (ICG) as the example, Mn-ICG@pHis-PEG display efficient pH-responsive tumor retention after systemic administration and then load Gambogic acid (GA), a natural inhibitor of heat-shock protein 90 (Hsp90) that plays an essential role for cells to resist heating-induced damage. Indocyanine Green 48-51 heat shock protein 90 alpha family class A member 1 Homo sapiens 220-241 28833643-4 2017 With NCPs consisting of Mn2+/indocyanine green (ICG) as the example, Mn-ICG@pHis-PEG display efficient pH-responsive tumor retention after systemic administration and then load Gambogic acid (GA), a natural inhibitor of heat-shock protein 90 (Hsp90) that plays an essential role for cells to resist heating-induced damage. Indocyanine Green 48-51 heat shock protein 90 alpha family class A member 1 Homo sapiens 243-248 33429587-8 2017 Furthermore, indocyanine green (ICG), a BTW fluorophore, was localized on the HNP surface, leading to fluorescence resonance energy transfer (FRET) from porphyrin to ICG only near the HNP surface. Indocyanine Green 13-30 kallikrein related peptidase 8 Homo sapiens 78-81 28875119-0 2017 Indocyanine Green Fluorescence to Evaluate Nasoseptal Flap Viability in Endoscopic Endonasal Cranial Base Surgery. Indocyanine Green 0-17 arachidonate 5-lipoxygenase activating protein Homo sapiens 54-58 28859104-5 2017 METHODS: The human HCC cell line HuH-7 was treated with ICG or ICG-lactosome, followed by PDT, and the cell viabilities were measured (in vitro PDT efficiency). Indocyanine Green 56-59 MIR7-3 host gene Homo sapiens 33-38 28859104-5 2017 METHODS: The human HCC cell line HuH-7 was treated with ICG or ICG-lactosome, followed by PDT, and the cell viabilities were measured (in vitro PDT efficiency). Indocyanine Green 63-66 MIR7-3 host gene Homo sapiens 33-38 28859104-8 2017 RESULTS: PDT had toxic effects on HuH-7 cells treated with ICG-lactosome, but not ICG alone. Indocyanine Green 59-62 MIR7-3 host gene Homo sapiens 34-39 28837560-3 2017 Small-molecule Wnt modulators such as ICG-001 and AZD2858 were used to inhibit and stimulate the Wnt/beta-catenin signaling pathway. Indocyanine Green 38-41 catenin beta 1 Homo sapiens 101-113 28578904-10 2017 The effect of Ang II is inhibited by losartan and ICG-001, a Wnt/beta-catenin inhibitor. Indocyanine Green 50-53 angiotensinogen Homo sapiens 14-20 28578904-10 2017 The effect of Ang II is inhibited by losartan and ICG-001, a Wnt/beta-catenin inhibitor. Indocyanine Green 50-53 catenin beta 1 Homo sapiens 65-77 28438626-6 2017 RESULTS: ICG localized to PC3 xenografts in the mice and all xenografts were highly fluorescent compared with surrounding tissues, with a median tumor-to-background ratio of 2.85 (interquartile range = 2.64-3.90). Indocyanine Green 9-12 chromobox 8 Mus musculus 26-29 28685058-6 2017 Similarly, a higher T/N ratio, which is the ratio of CDC34 expression in HCCs to that in non-tumorous tissues, was significantly associated with favorable features, such as a lower indocyanin green retention rate after 15 min (ICG15R), reduced alpha-fetoprotein and smaller tumor size. Indocyanine Green 181-197 cell division cycle 34, ubiqiutin conjugating enzyme Homo sapiens 53-58 28755860-8 2017 ICG clearance kinetics correlated with histological scores for acute liver damage for APAP (i.e. 3h timepoint; r=0.90, P<0.0001) and elevations in both of the mechanistic biomarkers, miR-122 (e.g. 6h timepoint; r=0.70, P=0.005) and HMGB1 (e.g. 6h timepoint; r=0.56, P=0.04). Indocyanine Green 0-3 microRNA 122 Mus musculus 186-193 28755860-8 2017 ICG clearance kinetics correlated with histological scores for acute liver damage for APAP (i.e. 3h timepoint; r=0.90, P<0.0001) and elevations in both of the mechanistic biomarkers, miR-122 (e.g. 6h timepoint; r=0.70, P=0.005) and HMGB1 (e.g. 6h timepoint; r=0.56, P=0.04). Indocyanine Green 0-3 high mobility group box 1 Mus musculus 235-240 28893318-2 2017 Given its ability to inhibit Wnt/beta-catenin signaling pathway, ICG-001 has been used in some tumor types to exert its anticarcinogenic effect. Indocyanine Green 65-68 catenin (cadherin associated protein), beta 1 Mus musculus 33-45 28893318-8 2017 RESULTS: In this study, we showed that ICG-001 significantly inhibited growth and metastasis of multiple GC cell lines, induced cell apoptosis, and augmented in vitro tumor spheres suppression when used in combination with chemotherapy drugs probably through robustly blocking association of beta-catenin with CBP and N-cadherin, but promoting association of beta-catenin with P300 and E-cadherin, instead of altering the distribution and expression of beta-catenin. Indocyanine Green 39-42 catenin (cadherin associated protein), beta 1 Mus musculus 292-304 28893318-8 2017 RESULTS: In this study, we showed that ICG-001 significantly inhibited growth and metastasis of multiple GC cell lines, induced cell apoptosis, and augmented in vitro tumor spheres suppression when used in combination with chemotherapy drugs probably through robustly blocking association of beta-catenin with CBP and N-cadherin, but promoting association of beta-catenin with P300 and E-cadherin, instead of altering the distribution and expression of beta-catenin. Indocyanine Green 39-42 CREB binding protein Mus musculus 310-313 28893318-8 2017 RESULTS: In this study, we showed that ICG-001 significantly inhibited growth and metastasis of multiple GC cell lines, induced cell apoptosis, and augmented in vitro tumor spheres suppression when used in combination with chemotherapy drugs probably through robustly blocking association of beta-catenin with CBP and N-cadherin, but promoting association of beta-catenin with P300 and E-cadherin, instead of altering the distribution and expression of beta-catenin. Indocyanine Green 39-42 cadherin 2 Mus musculus 318-328 28893318-8 2017 RESULTS: In this study, we showed that ICG-001 significantly inhibited growth and metastasis of multiple GC cell lines, induced cell apoptosis, and augmented in vitro tumor spheres suppression when used in combination with chemotherapy drugs probably through robustly blocking association of beta-catenin with CBP and N-cadherin, but promoting association of beta-catenin with P300 and E-cadherin, instead of altering the distribution and expression of beta-catenin. Indocyanine Green 39-42 catenin (cadherin associated protein), beta 1 Mus musculus 359-371 28893318-8 2017 RESULTS: In this study, we showed that ICG-001 significantly inhibited growth and metastasis of multiple GC cell lines, induced cell apoptosis, and augmented in vitro tumor spheres suppression when used in combination with chemotherapy drugs probably through robustly blocking association of beta-catenin with CBP and N-cadherin, but promoting association of beta-catenin with P300 and E-cadherin, instead of altering the distribution and expression of beta-catenin. Indocyanine Green 39-42 cadherin 1 Mus musculus 386-396 28893318-8 2017 RESULTS: In this study, we showed that ICG-001 significantly inhibited growth and metastasis of multiple GC cell lines, induced cell apoptosis, and augmented in vitro tumor spheres suppression when used in combination with chemotherapy drugs probably through robustly blocking association of beta-catenin with CBP and N-cadherin, but promoting association of beta-catenin with P300 and E-cadherin, instead of altering the distribution and expression of beta-catenin. Indocyanine Green 39-42 catenin (cadherin associated protein), beta 1 Mus musculus 359-371 28438509-4 2017 MATERIALS AND METHODS: In this study the effect of PDT based on indocyanine green (ICG) as a photosensitizer with the diode laser were tested on the expression of BAX and BCL-2 genes in monolayers of HGF cells. Indocyanine Green 64-81 BCL2 associated X, apoptosis regulator Homo sapiens 163-166 28438509-4 2017 MATERIALS AND METHODS: In this study the effect of PDT based on indocyanine green (ICG) as a photosensitizer with the diode laser were tested on the expression of BAX and BCL-2 genes in monolayers of HGF cells. Indocyanine Green 64-81 BCL2 apoptosis regulator Homo sapiens 171-176 28438509-4 2017 MATERIALS AND METHODS: In this study the effect of PDT based on indocyanine green (ICG) as a photosensitizer with the diode laser were tested on the expression of BAX and BCL-2 genes in monolayers of HGF cells. Indocyanine Green 64-81 hepatocyte growth factor Homo sapiens 200-203 28438509-4 2017 MATERIALS AND METHODS: In this study the effect of PDT based on indocyanine green (ICG) as a photosensitizer with the diode laser were tested on the expression of BAX and BCL-2 genes in monolayers of HGF cells. Indocyanine Green 83-86 BCL2 associated X, apoptosis regulator Homo sapiens 163-166 28438509-4 2017 MATERIALS AND METHODS: In this study the effect of PDT based on indocyanine green (ICG) as a photosensitizer with the diode laser were tested on the expression of BAX and BCL-2 genes in monolayers of HGF cells. Indocyanine Green 83-86 BCL2 apoptosis regulator Homo sapiens 171-176 28438509-4 2017 MATERIALS AND METHODS: In this study the effect of PDT based on indocyanine green (ICG) as a photosensitizer with the diode laser were tested on the expression of BAX and BCL-2 genes in monolayers of HGF cells. Indocyanine Green 83-86 hepatocyte growth factor Homo sapiens 200-203 28438509-8 2017 CONCLUSION: Our findings indicate that ICG-PDT at 1000mug/mL of ICG with the exposure time of 60s for the diode laser would appear to be an inducer of apoptosis in HGF at transcriptome level. Indocyanine Green 39-42 hepatocyte growth factor Homo sapiens 164-167 33429587-8 2017 Furthermore, indocyanine green (ICG), a BTW fluorophore, was localized on the HNP surface, leading to fluorescence resonance energy transfer (FRET) from porphyrin to ICG only near the HNP surface. Indocyanine Green 13-30 kallikrein related peptidase 8 Homo sapiens 184-187 33429587-8 2017 Furthermore, indocyanine green (ICG), a BTW fluorophore, was localized on the HNP surface, leading to fluorescence resonance energy transfer (FRET) from porphyrin to ICG only near the HNP surface. Indocyanine Green 32-35 kallikrein related peptidase 8 Homo sapiens 78-81 33429587-8 2017 Furthermore, indocyanine green (ICG), a BTW fluorophore, was localized on the HNP surface, leading to fluorescence resonance energy transfer (FRET) from porphyrin to ICG only near the HNP surface. Indocyanine Green 32-35 kallikrein related peptidase 8 Homo sapiens 184-187 28393763-1 2017 Here we report indocyanine green (ICG)-loaded hollow mesoporous silica nanoparticles (ICG@HMSNP) as an activatable theranostic platform. Indocyanine Green 15-32 HMSNO Homo sapiens 90-95 28587258-3 2017 Here we report a combination of ICG-PDT with a chemotherapy drug etoposide (VP-16), aiming to enhance the anticancer efficacy, to circumvent limitations of PDT using ICG, and to reduce side effects of VP-16. Indocyanine Green 32-35 host cell factor C1 Homo sapiens 76-81 28587258-3 2017 Here we report a combination of ICG-PDT with a chemotherapy drug etoposide (VP-16), aiming to enhance the anticancer efficacy, to circumvent limitations of PDT using ICG, and to reduce side effects of VP-16. Indocyanine Green 32-35 host cell factor C1 Homo sapiens 201-206 28587258-6 2017 Furthermore, by studying the treatment sequence dependence and the cytotoxicity of laser-irradiated mixtures of ICG and VP-16, we found that the observed synergy involves direct/indirect reactions between ICG and VP-16. Indocyanine Green 112-115 host cell factor C1 Homo sapiens 213-218 28587258-6 2017 Furthermore, by studying the treatment sequence dependence and the cytotoxicity of laser-irradiated mixtures of ICG and VP-16, we found that the observed synergy involves direct/indirect reactions between ICG and VP-16. Indocyanine Green 205-208 host cell factor C1 Homo sapiens 120-125 28587258-7 2017 We further propose that there exists an electron transfer reaction between ICG and VP-16 under irradiation. Indocyanine Green 75-78 host cell factor C1 Homo sapiens 83-88 28521752-0 2017 Synthesis, characterization, and biological verification of anti-HER2 indocyanine green-doxorubicin-loaded polyethyleneimine-coated perfluorocarbon double nanoemulsions for targeted photochemotherapy of breast cancer cells. Indocyanine Green 70-87 erb-b2 receptor tyrosine kinase 2 Homo sapiens 65-69 28521752-4 2017 In this study, we aimed to fabricate anti-HER2 indocyanine green (ICG)-doxorubicin (DOX)-loaded polyethyleneimine-coated perfluorocarbon double nanoemulsions (HIDPPDNEs) to explore the co-administration of phototherapy and chemotherapy for HER2-overexpressing breast cancer in vitro. Indocyanine Green 47-64 erb-b2 receptor tyrosine kinase 2 Homo sapiens 42-46 28521752-4 2017 In this study, we aimed to fabricate anti-HER2 indocyanine green (ICG)-doxorubicin (DOX)-loaded polyethyleneimine-coated perfluorocarbon double nanoemulsions (HIDPPDNEs) to explore the co-administration of phototherapy and chemotherapy for HER2-overexpressing breast cancer in vitro. Indocyanine Green 47-64 erb-b2 receptor tyrosine kinase 2 Homo sapiens 240-244 28521752-4 2017 In this study, we aimed to fabricate anti-HER2 indocyanine green (ICG)-doxorubicin (DOX)-loaded polyethyleneimine-coated perfluorocarbon double nanoemulsions (HIDPPDNEs) to explore the co-administration of phototherapy and chemotherapy for HER2-overexpressing breast cancer in vitro. Indocyanine Green 66-69 erb-b2 receptor tyrosine kinase 2 Homo sapiens 42-46 28521752-4 2017 In this study, we aimed to fabricate anti-HER2 indocyanine green (ICG)-doxorubicin (DOX)-loaded polyethyleneimine-coated perfluorocarbon double nanoemulsions (HIDPPDNEs) to explore the co-administration of phototherapy and chemotherapy for HER2-overexpressing breast cancer in vitro. Indocyanine Green 66-69 erb-b2 receptor tyrosine kinase 2 Homo sapiens 240-244 28521752-9 2017 CONCLUSIONS: This work demonstrates that the HIDPPDNEs are able to provide improved ICG stability, binding specificity, and enhanced anticancer efficacy as compared to equal dosage of free ICG and/or DOX, showing a high potential for use in HER2 breast cancer therapy with reduced chemotoxicity. Indocyanine Green 84-87 erb-b2 receptor tyrosine kinase 2 Homo sapiens 241-245 28521752-9 2017 CONCLUSIONS: This work demonstrates that the HIDPPDNEs are able to provide improved ICG stability, binding specificity, and enhanced anticancer efficacy as compared to equal dosage of free ICG and/or DOX, showing a high potential for use in HER2 breast cancer therapy with reduced chemotoxicity. Indocyanine Green 189-192 erb-b2 receptor tyrosine kinase 2 Homo sapiens 241-245 27099262-7 2017 Inhibition of T-cell factor (TCF)/beta-catenin-mediated transcription with ICG-001 or genetic loss of beta-catenin also prevented TGF-beta-induced myofibroblasts formation. Indocyanine Green 75-78 hepatocyte nuclear factor 4 alpha Homo sapiens 14-27 27099262-7 2017 Inhibition of T-cell factor (TCF)/beta-catenin-mediated transcription with ICG-001 or genetic loss of beta-catenin also prevented TGF-beta-induced myofibroblasts formation. Indocyanine Green 75-78 hepatocyte nuclear factor 4 alpha Homo sapiens 29-32 27099262-7 2017 Inhibition of T-cell factor (TCF)/beta-catenin-mediated transcription with ICG-001 or genetic loss of beta-catenin also prevented TGF-beta-induced myofibroblasts formation. Indocyanine Green 75-78 catenin beta 1 Homo sapiens 34-46 27099262-7 2017 Inhibition of T-cell factor (TCF)/beta-catenin-mediated transcription with ICG-001 or genetic loss of beta-catenin also prevented TGF-beta-induced myofibroblasts formation. Indocyanine Green 75-78 transforming growth factor beta 1 Homo sapiens 130-138 28393763-1 2017 Here we report indocyanine green (ICG)-loaded hollow mesoporous silica nanoparticles (ICG@HMSNP) as an activatable theranostic platform. Indocyanine Green 34-37 HMSNO Homo sapiens 90-95 28393763-1 2017 Here we report indocyanine green (ICG)-loaded hollow mesoporous silica nanoparticles (ICG@HMSNP) as an activatable theranostic platform. Indocyanine Green 86-89 HMSNO Homo sapiens 90-95 28393763-2 2017 Near-infrared fluorescence and singlet oxygen generation of ICG@HMSNP was effectively quenched (i.e. turned off) in its native state because of the fluorescence resonance energy transfer between ICG molecules. Indocyanine Green 60-63 HMSNO Homo sapiens 64-69 28393763-2 2017 Near-infrared fluorescence and singlet oxygen generation of ICG@HMSNP was effectively quenched (i.e. turned off) in its native state because of the fluorescence resonance energy transfer between ICG molecules. Indocyanine Green 195-198 HMSNO Homo sapiens 64-69 29237155-15 2017 However, the renoprotective effect of CM was blocked by ICG-001, characterized by exacerbated renal function, suppressed PGC-1alpha expression and increased mitochondrial ROS. Indocyanine Green 56-59 PPARG coactivator 1 alpha Homo sapiens 121-131 28302627-9 2017 Moreover, beta-catenin inhibitors PKF118-310 and ICG-001 limited growth of mouse and human vascular SMCs in a dose-dependent manner. Indocyanine Green 49-52 catenin (cadherin associated protein), beta 1 Mus musculus 10-22 28429764-0 2017 Fabrication, characterization, and biological evaluation of anti-HER2 indocyanine green-doxorubicin-encapsulated PEG-b-PLGA copolymeric nanoparticles for targeted photochemotherapy of breast cancer cells. Indocyanine Green 70-87 erb-b2 receptor tyrosine kinase 2 Homo sapiens 65-69 28429764-1 2017 In this study, we aimed to develop anti-human epidermal growth factor receptor 2 (HER2) indocyanine green (ICG)-doxorubicin (DOX)-encapsulated polyethylene glycol-poly(lactic-co-glycolic acid) diblock copolymeric nanoparticles (HIDPPNPs) to explore the co-administration of phototherapy and chemotherapy for HER2-overexpressing breast cancer, a highly aggressive and medicine-resistant breast carcinoma. Indocyanine Green 88-105 erb-b2 receptor tyrosine kinase 2 Homo sapiens 46-80 28429764-1 2017 In this study, we aimed to develop anti-human epidermal growth factor receptor 2 (HER2) indocyanine green (ICG)-doxorubicin (DOX)-encapsulated polyethylene glycol-poly(lactic-co-glycolic acid) diblock copolymeric nanoparticles (HIDPPNPs) to explore the co-administration of phototherapy and chemotherapy for HER2-overexpressing breast cancer, a highly aggressive and medicine-resistant breast carcinoma. Indocyanine Green 88-105 erb-b2 receptor tyrosine kinase 2 Homo sapiens 82-86 28429764-1 2017 In this study, we aimed to develop anti-human epidermal growth factor receptor 2 (HER2) indocyanine green (ICG)-doxorubicin (DOX)-encapsulated polyethylene glycol-poly(lactic-co-glycolic acid) diblock copolymeric nanoparticles (HIDPPNPs) to explore the co-administration of phototherapy and chemotherapy for HER2-overexpressing breast cancer, a highly aggressive and medicine-resistant breast carcinoma. Indocyanine Green 88-105 erb-b2 receptor tyrosine kinase 2 Homo sapiens 308-312 28429764-1 2017 In this study, we aimed to develop anti-human epidermal growth factor receptor 2 (HER2) indocyanine green (ICG)-doxorubicin (DOX)-encapsulated polyethylene glycol-poly(lactic-co-glycolic acid) diblock copolymeric nanoparticles (HIDPPNPs) to explore the co-administration of phototherapy and chemotherapy for HER2-overexpressing breast cancer, a highly aggressive and medicine-resistant breast carcinoma. Indocyanine Green 107-111 erb-b2 receptor tyrosine kinase 2 Homo sapiens 46-80 28429764-1 2017 In this study, we aimed to develop anti-human epidermal growth factor receptor 2 (HER2) indocyanine green (ICG)-doxorubicin (DOX)-encapsulated polyethylene glycol-poly(lactic-co-glycolic acid) diblock copolymeric nanoparticles (HIDPPNPs) to explore the co-administration of phototherapy and chemotherapy for HER2-overexpressing breast cancer, a highly aggressive and medicine-resistant breast carcinoma. Indocyanine Green 107-111 erb-b2 receptor tyrosine kinase 2 Homo sapiens 82-86 28429764-1 2017 In this study, we aimed to develop anti-human epidermal growth factor receptor 2 (HER2) indocyanine green (ICG)-doxorubicin (DOX)-encapsulated polyethylene glycol-poly(lactic-co-glycolic acid) diblock copolymeric nanoparticles (HIDPPNPs) to explore the co-administration of phototherapy and chemotherapy for HER2-overexpressing breast cancer, a highly aggressive and medicine-resistant breast carcinoma. Indocyanine Green 107-111 erb-b2 receptor tyrosine kinase 2 Homo sapiens 308-312 27624805-7 2017 Treatment with either XAV-939 or ICG-001 effectively inhibited activation of beta-catenin and downregulated mRNA expression of beta-catenin-targeted genes in TDI-asthmatic mice, paralleled by dramatically attenuated TDI-induced hyperresponsiveness and inflammation of the airway, alleviated airway goblet cell metaplasia and collagen deposition, decreased Th2 inflammation, as well as lower levels of TGFbeta1, VEGF, HMGB1, and IL-1beta. Indocyanine Green 33-36 catenin (cadherin associated protein), beta 1 Mus musculus 77-89 27624805-7 2017 Treatment with either XAV-939 or ICG-001 effectively inhibited activation of beta-catenin and downregulated mRNA expression of beta-catenin-targeted genes in TDI-asthmatic mice, paralleled by dramatically attenuated TDI-induced hyperresponsiveness and inflammation of the airway, alleviated airway goblet cell metaplasia and collagen deposition, decreased Th2 inflammation, as well as lower levels of TGFbeta1, VEGF, HMGB1, and IL-1beta. Indocyanine Green 33-36 catenin (cadherin associated protein), beta 1 Mus musculus 127-139 27624805-7 2017 Treatment with either XAV-939 or ICG-001 effectively inhibited activation of beta-catenin and downregulated mRNA expression of beta-catenin-targeted genes in TDI-asthmatic mice, paralleled by dramatically attenuated TDI-induced hyperresponsiveness and inflammation of the airway, alleviated airway goblet cell metaplasia and collagen deposition, decreased Th2 inflammation, as well as lower levels of TGFbeta1, VEGF, HMGB1, and IL-1beta. Indocyanine Green 33-36 transforming growth factor, beta 1 Mus musculus 401-409 27624805-7 2017 Treatment with either XAV-939 or ICG-001 effectively inhibited activation of beta-catenin and downregulated mRNA expression of beta-catenin-targeted genes in TDI-asthmatic mice, paralleled by dramatically attenuated TDI-induced hyperresponsiveness and inflammation of the airway, alleviated airway goblet cell metaplasia and collagen deposition, decreased Th2 inflammation, as well as lower levels of TGFbeta1, VEGF, HMGB1, and IL-1beta. Indocyanine Green 33-36 vascular endothelial growth factor A Mus musculus 411-415 27624805-7 2017 Treatment with either XAV-939 or ICG-001 effectively inhibited activation of beta-catenin and downregulated mRNA expression of beta-catenin-targeted genes in TDI-asthmatic mice, paralleled by dramatically attenuated TDI-induced hyperresponsiveness and inflammation of the airway, alleviated airway goblet cell metaplasia and collagen deposition, decreased Th2 inflammation, as well as lower levels of TGFbeta1, VEGF, HMGB1, and IL-1beta. Indocyanine Green 33-36 high mobility group box 1 Mus musculus 417-422 27624805-7 2017 Treatment with either XAV-939 or ICG-001 effectively inhibited activation of beta-catenin and downregulated mRNA expression of beta-catenin-targeted genes in TDI-asthmatic mice, paralleled by dramatically attenuated TDI-induced hyperresponsiveness and inflammation of the airway, alleviated airway goblet cell metaplasia and collagen deposition, decreased Th2 inflammation, as well as lower levels of TGFbeta1, VEGF, HMGB1, and IL-1beta. Indocyanine Green 33-36 interleukin 1 beta Mus musculus 428-436 27909239-4 2017 Using bevacizumab, an antibody directed against vascular endothelial growth factor that consequently inhibits neoangiogenesis, we sought to confirm the mode of ICG diffusion. Indocyanine Green 160-163 vascular endothelial growth factor A Homo sapiens 48-82 28088668-2 2017 In the present study, indocyanine green (ICG), a widely used near-infrared (NIR) dye in photothermal therapy, and chemotherapeutic drug-doxorubicin (DOX) were loaded within the nanoparticles of novel designed arylboronic ester and cholesterol modified hyaluronic acid (PPE-Chol1-HA), denoted as PCH-DI. Indocyanine Green 22-39 cholesterol 1 Mus musculus 273-278 28088668-2 2017 In the present study, indocyanine green (ICG), a widely used near-infrared (NIR) dye in photothermal therapy, and chemotherapeutic drug-doxorubicin (DOX) were loaded within the nanoparticles of novel designed arylboronic ester and cholesterol modified hyaluronic acid (PPE-Chol1-HA), denoted as PCH-DI. Indocyanine Green 41-44 cholesterol 1 Mus musculus 273-278 28029105-3 2017 Digestion of nanoparticles with cathepsin B, a matrix metalloproteinase overexpressed in the microenvironment of advanced tumours, decreased particle size and increased ICG cellular uptake. Indocyanine Green 169-172 cathepsin B Homo sapiens 32-43 28029105-4 2017 Incorporation of ICG in PGA nanoparticles provided the NIR-absorbing agent with time-dependent altered optical properties in the presence of cathepsin B. Indocyanine Green 17-20 NOC2 like nucleolar associated transcriptional repressor Homo sapiens 55-58 28029105-4 2017 Incorporation of ICG in PGA nanoparticles provided the NIR-absorbing agent with time-dependent altered optical properties in the presence of cathepsin B. Indocyanine Green 17-20 cathepsin B Homo sapiens 141-152 27856283-3 2017 In vivo studies show that the ICG component facilitates nIR fluorescence imaging that demonstrates accumulation of IV- administered nanoparticles in tumours. Indocyanine Green 30-33 NOC2 like nucleolar associated transcriptional repressor Homo sapiens 56-59 28460484-0 2017 The beta-catenin/CBP-antagonist ICG-001 inhibits pediatric glioma tumorigenicity in a Wnt-independent manner. Indocyanine Green 32-35 catenin beta 1 Homo sapiens 4-16 28460484-0 2017 The beta-catenin/CBP-antagonist ICG-001 inhibits pediatric glioma tumorigenicity in a Wnt-independent manner. Indocyanine Green 32-35 CREB binding protein Homo sapiens 17-20 28460484-5 2017 Nevertheless, low doses of ICG-001 inhibited cell migration/invasion, tumorsphere- and colony formation, proliferation in vitro as well as tumor growth in vivo/ovo, suggesting that ICG-001 affects pedHGG tumor cell characteristics independent of beta-catenin/Wnt-signaling. Indocyanine Green 27-30 catenin beta 1 Homo sapiens 246-258 28460484-6 2017 RNA-sequencing analyses support a Wnt/beta-catenin-independent effect of ICG-001 on target gene transcription, revealing strong effects on genes involved in cellular metabolic/biosynthetic processes and cell cycle progression. Indocyanine Green 73-76 catenin beta 1 Homo sapiens 38-50 27941556-3 2017 MATERIALS: In an established preclinical mouse model of bioluminescent Staphylococcus aureus PJI, fluorescent indocyanine green (ICG) was conjugated to beta-cyclodextrin (CDX-ICG) or teicoplanin (Teic-ICG) and injected intravenously for 1 week postoperatively. Indocyanine Green 110-127 caudal type homeobox 1 Mus musculus 171-174 27941556-3 2017 MATERIALS: In an established preclinical mouse model of bioluminescent Staphylococcus aureus PJI, fluorescent indocyanine green (ICG) was conjugated to beta-cyclodextrin (CDX-ICG) or teicoplanin (Teic-ICG) and injected intravenously for 1 week postoperatively. Indocyanine Green 129-132 caudal type homeobox 1 Mus musculus 171-174 27776285-4 2017 Because of the excellent fluorescent and photoacoustic properties, the tumor accumulation of the ICG-HANP/MnO2 (IHM) nanocomplex was monitored by fluorescent imaging and photoacoustic imaging after intravenous administration into the SCC7 tumor-bearing mouse model. Indocyanine Green 97-100 colon tumor susceptibility 7 Mus musculus 234-238 29141249-8 2017 Abolishment of their interaction by the Wnt/beta-catenin inhibitor ICG-001 remarkably suppressed cell proliferation. Indocyanine Green 67-70 catenin beta 1 Homo sapiens 44-56 27909720-7 2017 The GSK3beta inhibitor BIO maintained sphere formation and migration capacity in GSLCs, whereas the beta-catenin/TCF transcription inhibitor ICG-001 decreased sphere formation and the migration capacity of GSLCs. Indocyanine Green 141-144 catenin beta 1 Homo sapiens 100-112 27909720-7 2017 The GSK3beta inhibitor BIO maintained sphere formation and migration capacity in GSLCs, whereas the beta-catenin/TCF transcription inhibitor ICG-001 decreased sphere formation and the migration capacity of GSLCs. Indocyanine Green 141-144 hepatocyte nuclear factor 4 alpha Homo sapiens 113-116 27629364-4 2016 KEY RESULTS: ICG-001, a small-molecule compound that inhibits the beta-catenin/CREB-binding protein (CBP) interaction, strongly and dose-dependently inhibited serum-induced smooth muscle growth and TGFbeta1-induced production of extracellular matrix components in vitro. Indocyanine Green 13-16 catenin (cadherin associated protein), beta 1 Mus musculus 66-78 28571944-12 2017 CONCLUSIONS: In advanced cervical cancer (stage IB1 >2 cm), the detection rate and bilateral migration rate on real-time fluorescent SLN mapping were higher with ICG than with Tc99m radiotracer with or without blue dye. Indocyanine Green 165-168 mitogen-activated protein kinase 8 interacting protein 1 Homo sapiens 48-51 27942034-0 2016 Synthesis, Characterization, and Biological Evaluation of Anti-HER2 Indocyanine Green-Encapsulated PEG-Coated PLGA Nanoparticles for Targeted Phototherapy of Breast Cancer Cells. Indocyanine Green 68-85 erb-b2 receptor tyrosine kinase 2 Homo sapiens 63-67 27725278-17 2017 CONCLUSIONS: Laparoscopic SLN mapping after the hysteroscopic injection of ICG has comparable DRs with both radioactive tracer series and ICG series with cervical injection, overcoming the need for radioactive substances. Indocyanine Green 75-78 sarcolipin Homo sapiens 26-29 28405131-0 2017 Indocyanine Green-001 (ICG-001) Attenuates Wnt/beta-catenin-induces Myocardial Injury Following Sepsis. Indocyanine Green 0-17 catenin (cadherin associated protein), beta 1 Mus musculus 47-59 28405131-0 2017 Indocyanine Green-001 (ICG-001) Attenuates Wnt/beta-catenin-induces Myocardial Injury Following Sepsis. Indocyanine Green 23-26 catenin (cadherin associated protein), beta 1 Mus musculus 47-59 28405131-1 2017 OBJECTIVE: To investigate the mechanistic pathway of both indocyanine green (ICG)-001 in attenuated endotoxemia-induced cardiac depression through downregulation cardiac Wnt/ beta-catenin cell signaling. Indocyanine Green 58-75 catenin (cadherin associated protein), beta 1 Mus musculus 175-187 28405131-1 2017 OBJECTIVE: To investigate the mechanistic pathway of both indocyanine green (ICG)-001 in attenuated endotoxemia-induced cardiac depression through downregulation cardiac Wnt/ beta-catenin cell signaling. Indocyanine Green 77-80 catenin (cadherin associated protein), beta 1 Mus musculus 175-187 28405131-10 2017 CONCLUSION: Taken together, these data showed that ICG-001 improved LV function following sepsis through downregulation of Wnt/beta-catenin and serve as a potential mechanistic pathway ICG-001 in therapeutic cardiac endotoxemia in animal model. Indocyanine Green 51-54 catenin (cadherin associated protein), beta 1 Mus musculus 127-139 27629364-4 2016 KEY RESULTS: ICG-001, a small-molecule compound that inhibits the beta-catenin/CREB-binding protein (CBP) interaction, strongly and dose-dependently inhibited serum-induced smooth muscle growth and TGFbeta1-induced production of extracellular matrix components in vitro. Indocyanine Green 13-16 CREB binding protein Mus musculus 79-99 27629364-4 2016 KEY RESULTS: ICG-001, a small-molecule compound that inhibits the beta-catenin/CREB-binding protein (CBP) interaction, strongly and dose-dependently inhibited serum-induced smooth muscle growth and TGFbeta1-induced production of extracellular matrix components in vitro. Indocyanine Green 13-16 CREB binding protein Mus musculus 101-104 27629364-4 2016 KEY RESULTS: ICG-001, a small-molecule compound that inhibits the beta-catenin/CREB-binding protein (CBP) interaction, strongly and dose-dependently inhibited serum-induced smooth muscle growth and TGFbeta1-induced production of extracellular matrix components in vitro. Indocyanine Green 13-16 transforming growth factor, beta 1 Mus musculus 198-206 27629364-7 2016 However, beta-catenin target gene expression was highly increased in response to ovalbumin; this effect was prevented by topical treatment with ICG-001. Indocyanine Green 144-147 catenin (cadherin associated protein), beta 1 Mus musculus 9-21 26829564-1 2016 Choroidal neovascularization secondary to tuberculous serpiginous-like choroiditis (Tb-SLC) is uncommon and requires further invasive imaging, such as fluorescein and indocyanine green angiography. Indocyanine Green 167-184 C-C motif chemokine ligand 21 Homo sapiens 87-90 27933882-3 2016 We apply this concept to Nd3+ emitters, and we show both experimentally and theoretically that the optimal doping concentration of Nd3+ in colloidal NaYF4:Nd upconverting nanoparticles is increased from 2 to 20 mol% when an energy harvestor organic dye (indocyanine green, ICG) is anchored onto the nanoparticle surface, resulting in ~10 times upconversion brightness. Indocyanine Green 254-271 mitochondrially encoded NADH dehydrogenase 3 Homo sapiens 131-134 27589984-10 2016 Immunohistochemical staining and polymerase chain reaction analysis of a non-neoplastic site of the resected specimen showed very few expression of the organic anion-transporting polypeptide 1B3 (OATP1B3), which is usually expressed on the basolateral membrane of human hepatocytes and mediates the uptake of ICG. Indocyanine Green 309-312 solute carrier organic anion transporter family member 1B3 Homo sapiens 152-194 27589984-10 2016 Immunohistochemical staining and polymerase chain reaction analysis of a non-neoplastic site of the resected specimen showed very few expression of the organic anion-transporting polypeptide 1B3 (OATP1B3), which is usually expressed on the basolateral membrane of human hepatocytes and mediates the uptake of ICG. Indocyanine Green 309-312 solute carrier organic anion transporter family member 1B3 Homo sapiens 196-203 27589984-11 2016 CONCLUSIONS: In this case, we present a case of hepatectomy for HCC in a patient with ICG excretory defect, which may be attributable to a congenital disorder of OATP1B3 expression; however, an ICG excretory defect did not seem to have any effect on the short-term prognosis after hepatectomy. Indocyanine Green 86-89 solute carrier organic anion transporter family member 1B3 Homo sapiens 162-169 27059962-11 2016 100 % sensitivity for PT1 and PT2 was noticed with tissues stained with ICG to differentiate tumoral and non-tumoral tissue. Indocyanine Green 72-75 zinc finger protein 77 Homo sapiens 22-25 27933882-3 2016 We apply this concept to Nd3+ emitters, and we show both experimentally and theoretically that the optimal doping concentration of Nd3+ in colloidal NaYF4:Nd upconverting nanoparticles is increased from 2 to 20 mol% when an energy harvestor organic dye (indocyanine green, ICG) is anchored onto the nanoparticle surface, resulting in ~10 times upconversion brightness. Indocyanine Green 273-276 mitochondrially encoded NADH dehydrogenase 3 Homo sapiens 131-134 27933882-4 2016 Theoretical analysis indicated that a combination of efficient photon harvesting due to the large absorption cross section of ICG (~30 000 times higher than that of Nd3+), non-radiative energy transfer (efficiency ~57%) from ICG to the surface bound Nd3+ ions, and energy migration among the Nd3+ ions was able to activate Nd3+ ions inside the nanoparticle at a rate comparable with that of the pronounced short-range quenching interaction at elevated Nd3+ concentrations. Indocyanine Green 225-228 mitochondrially encoded NADH dehydrogenase 3 Homo sapiens 165-168 27933882-4 2016 Theoretical analysis indicated that a combination of efficient photon harvesting due to the large absorption cross section of ICG (~30 000 times higher than that of Nd3+), non-radiative energy transfer (efficiency ~57%) from ICG to the surface bound Nd3+ ions, and energy migration among the Nd3+ ions was able to activate Nd3+ ions inside the nanoparticle at a rate comparable with that of the pronounced short-range quenching interaction at elevated Nd3+ concentrations. Indocyanine Green 225-228 mitochondrially encoded NADH dehydrogenase 3 Homo sapiens 250-253 27933882-4 2016 Theoretical analysis indicated that a combination of efficient photon harvesting due to the large absorption cross section of ICG (~30 000 times higher than that of Nd3+), non-radiative energy transfer (efficiency ~57%) from ICG to the surface bound Nd3+ ions, and energy migration among the Nd3+ ions was able to activate Nd3+ ions inside the nanoparticle at a rate comparable with that of the pronounced short-range quenching interaction at elevated Nd3+ concentrations. Indocyanine Green 225-228 mitochondrially encoded NADH dehydrogenase 3 Homo sapiens 250-253 27933882-4 2016 Theoretical analysis indicated that a combination of efficient photon harvesting due to the large absorption cross section of ICG (~30 000 times higher than that of Nd3+), non-radiative energy transfer (efficiency ~57%) from ICG to the surface bound Nd3+ ions, and energy migration among the Nd3+ ions was able to activate Nd3+ ions inside the nanoparticle at a rate comparable with that of the pronounced short-range quenching interaction at elevated Nd3+ concentrations. Indocyanine Green 225-228 mitochondrially encoded NADH dehydrogenase 3 Homo sapiens 250-253 27933882-4 2016 Theoretical analysis indicated that a combination of efficient photon harvesting due to the large absorption cross section of ICG (~30 000 times higher than that of Nd3+), non-radiative energy transfer (efficiency ~57%) from ICG to the surface bound Nd3+ ions, and energy migration among the Nd3+ ions was able to activate Nd3+ ions inside the nanoparticle at a rate comparable with that of the pronounced short-range quenching interaction at elevated Nd3+ concentrations. Indocyanine Green 225-228 mitochondrially encoded NADH dehydrogenase 3 Homo sapiens 250-253 27164548-7 2016 The areas showing abnormalities in the OCT-angiography were congruent with leaking areas in fluorescein angiography or areas with hyperpermeability in indocyanine green angiography. Indocyanine Green 151-168 plexin A2 Homo sapiens 39-42 27812143-11 2016 In addition to this, ICG-clearance on postoperative day 1 comparably predicted postoperative liver dysfunction (Area under the curve = PDR: 0.895; R15: 0.893; both P <0.001), specifically, PDR <10%/min or R15 >20% on postoperative day 1 predicted poor postoperative outcome. Indocyanine Green 21-24 PDR Homo sapiens 135-138 27812143-11 2016 In addition to this, ICG-clearance on postoperative day 1 comparably predicted postoperative liver dysfunction (Area under the curve = PDR: 0.895; R15: 0.893; both P <0.001), specifically, PDR <10%/min or R15 >20% on postoperative day 1 predicted poor postoperative outcome. Indocyanine Green 21-24 PDR Homo sapiens 192-195 27567978-5 2016 Rather, one of powerful Wnt/beta-catenin signaling inhibitors, ICG-001, increased the pigmentation of HM3KO melanoma cells. Indocyanine Green 63-66 catenin beta 1 Homo sapiens 28-40 27845386-8 2016 In addition, we showed that miR-101 overexpression promoted the expression of Wnt genes, resulting in the activation of the Wnt/beta-catenin signaling pathway by targeting EZH2, while the activity of beta-catenin and the Wnt/beta-catenin signaling pathway was inhibited by ICG-001, a beta-Catenin inhibitor, which reversed the promoting effect of miR-101. Indocyanine Green 273-276 catenin beta 1 Homo sapiens 128-140 27845386-8 2016 In addition, we showed that miR-101 overexpression promoted the expression of Wnt genes, resulting in the activation of the Wnt/beta-catenin signaling pathway by targeting EZH2, while the activity of beta-catenin and the Wnt/beta-catenin signaling pathway was inhibited by ICG-001, a beta-Catenin inhibitor, which reversed the promoting effect of miR-101. Indocyanine Green 273-276 enhancer of zeste 2 polycomb repressive complex 2 subunit Homo sapiens 172-176 27431312-6 2016 Mechanistically, sorafenib combined with ICG-001 or shRNA-mediated beta-catenin downregulation augmented the induction of apoptosis, and resulted in a significant downregulation of Mcl-1 in HCC cells. Indocyanine Green 41-44 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 181-186 27895355-6 2016 The calculated ASGPR level was derived as: 80.695 + 0.002 x cholinesterases (CHE) (IU/L) - 0.620 x indocyanine green retention rate at 15 min (ICGR15)(%) - 0.655 x total bilirubin (TB) (umol/L). Indocyanine Green 99-116 asialoglycoprotein receptor 1 Homo sapiens 15-20 27353484-0 2016 Macrophage-Targeted Indocyanine Green-Neomannosyl Human Serum Albumin for Intraoperative Sentinel Lymph Node Mapping in Porcine Esophagus. Indocyanine Green 20-37 albumin Homo sapiens 56-69 27353484-2 2016 This study evaluated a new macrophage-targeting fluorescent agent, indocyanine green-neomannosyl human serum albumin (ICG:MSA), for SLN mapping using a custom-made intraoperative color and fluorescence-merged imaging system (ICFIS) in porcine esophagus. Indocyanine Green 67-84 albumin Homo sapiens 103-116 27353484-3 2016 METHODS: The LN targeting ability of ICG:MSA, indocyanine green-human serum albumin (ICG:HSA), and ICG was examined in vitro using the U937 differentiated monocyte cell line and in vivo in a mouse footpad model using fluorescence imaging. Indocyanine Green 46-63 albumin Homo sapiens 70-83 26657156-2 2016 ICG-001 is a small-molecule inhibitor that specifically inhibits the CBP/catenin interaction. Indocyanine Green 0-3 CREB binding protein Homo sapiens 69-72 27528256-2 2016 Herein, we report a green and facile strategy to fabricate transferrin-indocyanine green nanoparticles as a smart theranostic agent with intrinsic biosafety and active targeting abilities for near-infrared fluorescent imaging and photothermal therapy of tumors. Indocyanine Green 71-88 transferrin Homo sapiens 59-70 27528256-4 2016 The transferrin-indocyanine green nanoparticles show great potential in theranostic applications of tumors in clinical therapy. Indocyanine Green 16-33 transferrin Homo sapiens 4-15 27544892-18 2016 (Indocyanine Green Fluorescence Uptake in Human Carotid Artery Plaque [BRIGHT-CEA]; NCT01873716). Indocyanine Green 1-18 CEA cell adhesion molecule 3 Homo sapiens 78-81 27556627-5 2016 The elevated flap was categorized into the early-stained area, the delayed-stained area, and the no-stained area by indocyanine green angiography. Indocyanine Green 116-133 arachidonate 5-lipoxygenase activating protein Homo sapiens 13-17 26715024-8 2016 After a pilot experiment of the survival model (Pig A), a hyperthermic pressurized intraperitoneal aerosol of indocyanine green was administered after insertion of three trocars (Pig B) and laparoscopy-assisted distal gastrectomy (LADG) (Pig C) without chemotherapeutic agents. Indocyanine Green 110-127 phosphatidylinositol glycan anchor biosynthesis class B Sus scrofa 179-184 27020580-8 2016 The percentage injected dose (% ID), the amount of ICG (in nmol), and the concentration of ICG in the SNs (in muM) was assessed for SNs detected on SPECT/CT and correlated with the intraoperative fluorescence imaging findings. Indocyanine Green 91-94 latexin Homo sapiens 110-113 27020580-11 2016 The % ID values could be correlated to the amount ICG in a SN (range: 0.003-10.8 nmol) and the concentration of ICG in a SN (range: 0.006-64.6 muM). Indocyanine Green 112-115 latexin Homo sapiens 143-146 27020580-13 2016 Our findings indicate that intraoperative fluorescence detection with ICG is possible above a muM concentration. Indocyanine Green 70-73 latexin Homo sapiens 94-97 27548771-1 2016 We investigated the optical properties of a near-infrared (NIR) fluorochrome, di-beta-cyclodextrin-binding indocyanine derivative (TK-1), and its pharmacokinetic differences with indocyanine green (ICG). Indocyanine Green 179-196 thymidine kinase 1 Rattus norvegicus 131-135 27548771-1 2016 We investigated the optical properties of a near-infrared (NIR) fluorochrome, di-beta-cyclodextrin-binding indocyanine derivative (TK-1), and its pharmacokinetic differences with indocyanine green (ICG). Indocyanine Green 198-201 thymidine kinase 1 Rattus norvegicus 131-135 27548771-2 2016 TK-1 was designed to have hydrophilic cyclodextrin molecules and, thus, for higher water solubility and smaller particle sizes than the plasma protein-bound ICG. Indocyanine Green 157-160 thymidine kinase 1 Rattus norvegicus 0-4 27548771-7 2016 The results of this study showed that lymphatic and venous transport can be differentially regulated and is most likely influenced primarily by particle size, and that TK-1 can enable real-time NIR fluorescence imaging of whole fluids and solute movement via both microvessels and lymphatics, which conventional ICG cannot achieve. Indocyanine Green 312-315 thymidine kinase 1 Rattus norvegicus 168-172 26657156-4 2016 We demonstrate that specifically inhibiting the interaction between CBP and catenin with ICG-001 results in the differentiation of quiescent drug-resistant chronic myelogenous leukemia-initiating cells (CML LICs), thereby sensitizing them to BCR-ABL tyrosine kinase inhibitors, for example, Imatinib. Indocyanine Green 89-92 CREB binding protein Homo sapiens 68-71 26657156-7 2016 Results from these studies demonstrate that specifically antagonizing the CBP/catenin interaction with ICG-001 can eliminate drug-resistant CML LICs without deleterious effects to the normal endogenous hematopoietic stem cell population. Indocyanine Green 103-106 CREB binding protein Homo sapiens 74-77 26763377-7 2016 Based upon Indocyanine Green encapsulation within the nanoparticles, UPA ligand targeted MSNs demonstrated increased intensity compared to untargeted MSNs at both pH7.4 (7x) and 6.5 (20x); however the signal was much more pronounced at a pH of 6.5 using tissue phantoms (p<0.05). Indocyanine Green 11-28 plasminogen activator, urokinase Homo sapiens 69-72 27399687-10 2016 We developed functionalized silica nanoparticles loaded with (99m)Tc and ICG for the targeting and imaging of HER2-expressing cells. Indocyanine Green 73-76 erb-b2 receptor tyrosine kinase 2 Homo sapiens 110-114 26714944-5 2016 The overall DR of SLN mapping was 97, 89, and 100 % for (99m)Tc with blue dye, blue dye alone, and ICG, respectively. Indocyanine Green 99-102 sarcolipin Homo sapiens 18-21 26853187-0 2016 A novel photoacoustic nanoprobe of ICG@PEG-Ag2S for atherosclerosis targeting and imaging in vivo. Indocyanine Green 35-38 angiotensin II receptor, type 1a Mus musculus 43-47 26853187-4 2016 The ICG@PEG-Ag2S nanoprobe showed relatively long blood retention and was selectively accumulated in the region of atherosclerotic plaque due to the lipophilicity of the C18 chain to the atherosclerosis microenvironment, and thus the atherosclerosis was real-time monitored by high contrast-enhanced photoacoustic (PA) imaging of ICG. Indocyanine Green 4-7 angiotensin II receptor, type 1a Mus musculus 12-16 26853187-6 2016 Additionally, hemolysis and coagulation assays of the ICG@PEG-Ag2S revealed its decent hemocompatibility and no histological changes were observed in the main organs of the mouse. Indocyanine Green 54-57 angiotensin II receptor, type 1a Mus musculus 62-66 27424607-4 2016 Conjugates of the Ki-67 antibody TuBB-9 with different amounts of ICG were synthesized and delivered into HeLa and OVCAR-5 cells through conjugation to the nuclear localization sequence. Indocyanine Green 66-69 tubulin beta class I Homo sapiens 33-37 26957367-9 2016 We further demonstrated that migration of ALCs was inhibited in vitro and that E-cadherin expression was significantly up-regulated when ALCs were treated with the beta-catenin inhibitor, ICG-001. Indocyanine Green 188-191 cadherin 1 Mus musculus 79-89 27245664-8 2016 CONCLUSIONS: The significant difference in the intensity as measured by an imaging-software between ICG-positive and ICG-negative lymph nodes would erase the concern about the objectivity of the infrared ICG method for SLN-navigated surgery for early gastric cancer. Indocyanine Green 100-103 sarcolipin Homo sapiens 219-222 27245664-8 2016 CONCLUSIONS: The significant difference in the intensity as measured by an imaging-software between ICG-positive and ICG-negative lymph nodes would erase the concern about the objectivity of the infrared ICG method for SLN-navigated surgery for early gastric cancer. Indocyanine Green 117-120 sarcolipin Homo sapiens 219-222 26957367-9 2016 We further demonstrated that migration of ALCs was inhibited in vitro and that E-cadherin expression was significantly up-regulated when ALCs were treated with the beta-catenin inhibitor, ICG-001. Indocyanine Green 188-191 catenin (cadherin associated protein), beta 1 Mus musculus 164-176 26743660-3 2016 In this study, we developed indocyanine green (ICG)-encapsulated micelles specific for the CD 44 receptor and used in near infrared and photoacoustic imaging of tumors. Indocyanine Green 28-45 CD44 antigen Mus musculus 91-96 26453613-8 2016 Conversely, blockade of Wnt/beta-catenin by small molecule inhibitor ICG-001 at this point hindered AKI to CKD progression. Indocyanine Green 69-72 catenin (cadherin associated protein), beta 1 Mus musculus 28-40 27107701-4 2016 We screened the effects of candidate transcription factors Hnf1b, Hnf1a, Hnf4a, Foxa1, Foxa3 and Hex, and determined that the combination of Hnf1b/Foxa3 promoted expression of several hepatic lineage-specific markers and proteins, in addition to glycogen storage, ICG uptake, and secretion of albumin and urea. Indocyanine Green 264-267 HNF1 homeobox B Mus musculus 141-146 27107701-4 2016 We screened the effects of candidate transcription factors Hnf1b, Hnf1a, Hnf4a, Foxa1, Foxa3 and Hex, and determined that the combination of Hnf1b/Foxa3 promoted expression of several hepatic lineage-specific markers and proteins, in addition to glycogen storage, ICG uptake, and secretion of albumin and urea. Indocyanine Green 264-267 forkhead box A3 Mus musculus 147-152 27177606-5 2016 ICG-001 and ICG-427 inhibit CBP- and p300-mediated Wnt activity, respectively, while IQ-1 prevents the shift from CBP-mediated to a p300-mediated Wnt activity. Indocyanine Green 0-3 CREB binding protein Homo sapiens 28-31 27177606-5 2016 ICG-001 and ICG-427 inhibit CBP- and p300-mediated Wnt activity, respectively, while IQ-1 prevents the shift from CBP-mediated to a p300-mediated Wnt activity. Indocyanine Green 0-3 E1A binding protein p300 Homo sapiens 37-41 27177606-5 2016 ICG-001 and ICG-427 inhibit CBP- and p300-mediated Wnt activity, respectively, while IQ-1 prevents the shift from CBP-mediated to a p300-mediated Wnt activity. Indocyanine Green 12-15 CREB binding protein Homo sapiens 28-31 27177606-5 2016 ICG-001 and ICG-427 inhibit CBP- and p300-mediated Wnt activity, respectively, while IQ-1 prevents the shift from CBP-mediated to a p300-mediated Wnt activity. Indocyanine Green 12-15 E1A binding protein p300 Homo sapiens 37-41 27113525-0 2016 Blood Flow Assessment with Indocyanine Green Fluorescence Angiography for Pedicled Omental Flap on Cervical Esophagogastric Anastomosis after Esophagectomy. Indocyanine Green 27-44 arachidonate 5-lipoxygenase activating protein Homo sapiens 91-95 27041628-10 2016 ICG uptake after TT correlated with post-operative PTH levels: mean POD#1 PTH of those patients with at least two PGs exhibiting <30% fluorescence was 9 pg/ml; whereas those with fewer than two demonstrating <30% fluorescence had a POD#1 PTH of 19.5 pg/ml (P = 0.05). Indocyanine Green 0-3 parathyroid hormone Homo sapiens 51-54 27041628-10 2016 ICG uptake after TT correlated with post-operative PTH levels: mean POD#1 PTH of those patients with at least two PGs exhibiting <30% fluorescence was 9 pg/ml; whereas those with fewer than two demonstrating <30% fluorescence had a POD#1 PTH of 19.5 pg/ml (P = 0.05). Indocyanine Green 0-3 parathyroid hormone Homo sapiens 74-77 27041628-10 2016 ICG uptake after TT correlated with post-operative PTH levels: mean POD#1 PTH of those patients with at least two PGs exhibiting <30% fluorescence was 9 pg/ml; whereas those with fewer than two demonstrating <30% fluorescence had a POD#1 PTH of 19.5 pg/ml (P = 0.05). Indocyanine Green 0-3 parathyroid hormone Homo sapiens 74-77 26948476-2 2016 Cardiac output was determined using the non-invasive Penaz technique, and plasma disappearance rate of indocyanine green (ICG-PDR) was measured as a surrogate maker for hepatic blood flow along with serum hepatic enzyme assays. Indocyanine Green 103-120 PDR Homo sapiens 126-129 26948476-2 2016 Cardiac output was determined using the non-invasive Penaz technique, and plasma disappearance rate of indocyanine green (ICG-PDR) was measured as a surrogate maker for hepatic blood flow along with serum hepatic enzyme assays. Indocyanine Green 122-125 PDR Homo sapiens 126-129 26743660-3 2016 In this study, we developed indocyanine green (ICG)-encapsulated micelles specific for the CD 44 receptor and used in near infrared and photoacoustic imaging of tumors. Indocyanine Green 47-50 CD44 antigen Mus musculus 91-96 26743660-4 2016 ICG was hydrophobically modified prior to loading into hyaluronic acid (HA)-based micelles utilized for CD 44 based-targeting. Indocyanine Green 0-3 CD44 antigen Mus musculus 104-109 26997463-9 2016 CONCLUSION: Detection SLN using optonuclear probe after indocyanine green and radio-isotope injections is effective and could be, after validation by randomized trial, a reliable alternative to the blue dye injection for teams who consider that combined detection as the reference. Indocyanine Green 56-73 sarcolipin Homo sapiens 22-25 29878729-6 2016 Studies on drug release demonstrated that the release of ICG in H-LipoICG was slower than LipoICG, which suggests that HSA may reduce the ICG leakage from liposome, the fluorescence intensity could be enhanced in the nanoprobe. Indocyanine Green 57-60 albumin Homo sapiens 119-122 29878729-6 2016 Studies on drug release demonstrated that the release of ICG in H-LipoICG was slower than LipoICG, which suggests that HSA may reduce the ICG leakage from liposome, the fluorescence intensity could be enhanced in the nanoprobe. Indocyanine Green 70-73 albumin Homo sapiens 119-122 26860184-4 2016 Herein, we developed a CD44 targeted photoacoustic (PA) nanophototherapy agent by conjugating Indocyanine Green (ICG) to hyaluronic acid nanoparticles (HANPs) encapsulated with single-walled carbon nanotubes (SWCNTs), resulting in a theranostic nanocomplex of ICG-HANP/SWCNTs (IHANPT). Indocyanine Green 94-111 CD44 antigen Mus musculus 23-27 26904983-4 2016 All MHs were treated with pars plana vitrectomy and indocyanine green-assisted inverted ILM flap technique. Indocyanine Green 52-69 arachidonate 5-lipoxygenase activating protein Homo sapiens 92-96 26860184-4 2016 Herein, we developed a CD44 targeted photoacoustic (PA) nanophototherapy agent by conjugating Indocyanine Green (ICG) to hyaluronic acid nanoparticles (HANPs) encapsulated with single-walled carbon nanotubes (SWCNTs), resulting in a theranostic nanocomplex of ICG-HANP/SWCNTs (IHANPT). Indocyanine Green 113-116 CD44 antigen Mus musculus 23-27 26860184-4 2016 Herein, we developed a CD44 targeted photoacoustic (PA) nanophototherapy agent by conjugating Indocyanine Green (ICG) to hyaluronic acid nanoparticles (HANPs) encapsulated with single-walled carbon nanotubes (SWCNTs), resulting in a theranostic nanocomplex of ICG-HANP/SWCNTs (IHANPT). Indocyanine Green 260-263 CD44 antigen Mus musculus 23-27 26569066-2 2016 A noninvasive measurement of indocyanine green clearance, the plasma disappearance rate (PDR), has been associated with initial graft function. Indocyanine Green 29-46 PDR Homo sapiens 89-92 26783025-5 2016 With this article, we report on the feasibility and effectiveness of a simple indocyanine green videoangiography (ICG-VA)-assisted technique for the identification of the STA branches from the underside of a fronto-temporal scalp flap in bypass surgery. Indocyanine Green 78-95 GCY Homo sapiens 171-174 26981173-1 2016 Indocyanine green (ICG) kinetics (PDR/R15) used to quantitatively assess hepatic function in the perioperative period of major resective surgery and liver transplantation have been the object of an extensive, updated and critical review. Indocyanine Green 0-17 PDR Homo sapiens 34-41 26981173-1 2016 Indocyanine green (ICG) kinetics (PDR/R15) used to quantitatively assess hepatic function in the perioperative period of major resective surgery and liver transplantation have been the object of an extensive, updated and critical review. Indocyanine Green 19-22 PDR Homo sapiens 34-41 26482083-3 2015 In this study, we have covalently conjugated ICG-NH2 to the pendant carboxyl groups of poly (ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate) (PEG-PCC) copolymer using carbodiimide coupling, which self-assembled into micelles with a particle size of 30-50 nm and high ICG loading. Indocyanine Green 45-48 crystallin gamma D Homo sapiens 167-170 25801355-0 2016 Visualization of Lymph/Blood Flow in Laparoscopic Colorectal Cancer Surgery by ICG Fluorescence Imaging (Lap-IGFI). Indocyanine Green 79-82 LAP Homo sapiens 37-40 25801355-0 2016 Visualization of Lymph/Blood Flow in Laparoscopic Colorectal Cancer Surgery by ICG Fluorescence Imaging (Lap-IGFI). Indocyanine Green 79-82 insulin like growth factor 1 Homo sapiens 109-113 25801355-2 2016 We performed visualization of the lymph and blood flow by laparoscopic indocyanine green (ICG) fluorescence imaging (Lap-IGFI). Indocyanine Green 71-88 LAP Homo sapiens 117-120 25801355-2 2016 We performed visualization of the lymph and blood flow by laparoscopic indocyanine green (ICG) fluorescence imaging (Lap-IGFI). Indocyanine Green 90-93 LAP Homo sapiens 117-120 26828431-0 2016 Peptide-Based Optical uPAR Imaging for Surgery: In Vivo Testing of ICG-Glu-Glu-AE105. Indocyanine Green 67-70 plasminogen activator, urokinase receptor Homo sapiens 22-26 26828431-5 2016 Conjugation of the flourophor indocyanine green (ICG) to the uPAR agonist (AE105) provides an optical imaging ligand with sufficiently high receptor affinity to allow for a specific receptor targeting in vivo. Indocyanine Green 30-47 plasminogen activator, urokinase receptor Homo sapiens 61-65 26828431-5 2016 Conjugation of the flourophor indocyanine green (ICG) to the uPAR agonist (AE105) provides an optical imaging ligand with sufficiently high receptor affinity to allow for a specific receptor targeting in vivo. Indocyanine Green 49-52 plasminogen activator, urokinase receptor Homo sapiens 61-65 26828431-8 2016 Specificity of the uPAR-targeting probe ICG-AE105 was demonstrated in vivo by 1) no uptake of unconjugated ICG after 15 hours, 2) inhibition of ICG-AE105 tumor uptake by a bolus injection of the natural uPAR ligand pro-uPA, and finally 3) the histological colocalization of ICG-AE105 fluorescence and immunohistochemical detected human uPAR on resected tumor slides. Indocyanine Green 40-43 plasminogen activator, urokinase receptor Homo sapiens 19-23 26828431-8 2016 Specificity of the uPAR-targeting probe ICG-AE105 was demonstrated in vivo by 1) no uptake of unconjugated ICG after 15 hours, 2) inhibition of ICG-AE105 tumor uptake by a bolus injection of the natural uPAR ligand pro-uPA, and finally 3) the histological colocalization of ICG-AE105 fluorescence and immunohistochemical detected human uPAR on resected tumor slides. Indocyanine Green 40-43 plasminogen activator, urokinase receptor Homo sapiens 203-207 26828431-8 2016 Specificity of the uPAR-targeting probe ICG-AE105 was demonstrated in vivo by 1) no uptake of unconjugated ICG after 15 hours, 2) inhibition of ICG-AE105 tumor uptake by a bolus injection of the natural uPAR ligand pro-uPA, and finally 3) the histological colocalization of ICG-AE105 fluorescence and immunohistochemical detected human uPAR on resected tumor slides. Indocyanine Green 40-43 plasminogen activator, urokinase receptor Homo sapiens 203-207 26828431-8 2016 Specificity of the uPAR-targeting probe ICG-AE105 was demonstrated in vivo by 1) no uptake of unconjugated ICG after 15 hours, 2) inhibition of ICG-AE105 tumor uptake by a bolus injection of the natural uPAR ligand pro-uPA, and finally 3) the histological colocalization of ICG-AE105 fluorescence and immunohistochemical detected human uPAR on resected tumor slides. Indocyanine Green 107-110 plasminogen activator, urokinase receptor Homo sapiens 19-23 25773774-4 2015 RESULTS: Significant independent determinants of serum WFA(+)-M2BP levels included pathological diagnosis of cirrhosis, female gender, hepatitis C virus (HCV) infection, and liver dysfunction characteristics, such as abnormal indocyanine green retention rate at 15 min, platelet counts, albumin levels, alanine aminotransferase levels, and total bilirubin levels. Indocyanine Green 226-243 galectin 3 binding protein Homo sapiens 62-66 26555151-2 2015 This follow-on study has specifically evaluated a combination of ICG and blue dye for SLN localization. Indocyanine Green 65-68 sarcolipin Homo sapiens 86-89 26555151-12 2015 CONCLUSION: Fluorescent imaging with ICG is a sensitive, valuable and safe method for SLN biopsy. Indocyanine Green 37-40 sarcolipin Homo sapiens 86-89 26335198-0 2015 Intraoperative Free Flap Monitoring Using Indocyanine Green. Indocyanine Green 42-59 arachidonate 5-lipoxygenase activating protein Homo sapiens 20-24 26315281-6 2015 We treated monolayer cultures of human airway epithelial cells with TGFbeta1 in the presence or absence of the selective small molecule ICG-001 to inhibit beta-catenin/CBP signaling. Indocyanine Green 136-139 catenin beta 1 Homo sapiens 155-167 26315281-6 2015 We treated monolayer cultures of human airway epithelial cells with TGFbeta1 in the presence or absence of the selective small molecule ICG-001 to inhibit beta-catenin/CBP signaling. Indocyanine Green 136-139 CREB binding protein Homo sapiens 168-171 26315281-10 2015 Either co-treatment or therapeutic administration of ICG-001 completely inhibited TGFbeta1-induced EMT. Indocyanine Green 53-56 transforming growth factor beta 1 Homo sapiens 82-90 26315281-11 2015 ICG-001 also reduced the expression of ck-5 and -19 independent of TGFbeta1. Indocyanine Green 0-3 transforming growth factor beta 1 Homo sapiens 67-75 26209419-3 2015 The purpose of this study was to evaluate the clinical benefit of double SLN mapping with indocyanine green (ICG) and 99m-technetium-tin colloid ((99m)Tc-tin colloid) for sentinel node navigation surgery (SNNS). Indocyanine Green 109-112 sarcolipin Homo sapiens 73-76 26209419-3 2015 The purpose of this study was to evaluate the clinical benefit of double SLN mapping with indocyanine green (ICG) and 99m-technetium-tin colloid ((99m)Tc-tin colloid) for sentinel node navigation surgery (SNNS). Indocyanine Green 90-107 sarcolipin Homo sapiens 73-76 26125441-10 2015 Taken together, our data is the first report providing evidence that the Wnt/beta-catenin signaling pathway maintains stem-like properties and drug resistance of primary HGSOC PDX derived platinum resistant models, and therapeutic targeting of this pathway with iCG-001/PRI-724, which has been shown to be well tolerated in Phase I trials, may be an effective treatment option. Indocyanine Green 262-265 catenin beta 1 Homo sapiens 77-89 26400780-3 2015 Here we report a noninvasive NIR-driven, temperature-sensitive DI-TSL (DOX/ICG-loaded temperature sensitive liposomes) co-encapsulating doxorubicin (DOX) and indocyanine green (ICG). Indocyanine Green 75-78 NOC2 like nucleolar associated transcriptional repressor Homo sapiens 29-32 26400780-3 2015 Here we report a noninvasive NIR-driven, temperature-sensitive DI-TSL (DOX/ICG-loaded temperature sensitive liposomes) co-encapsulating doxorubicin (DOX) and indocyanine green (ICG). Indocyanine Green 75-78 TSL Homo sapiens 66-69 26400780-3 2015 Here we report a noninvasive NIR-driven, temperature-sensitive DI-TSL (DOX/ICG-loaded temperature sensitive liposomes) co-encapsulating doxorubicin (DOX) and indocyanine green (ICG). Indocyanine Green 158-175 NOC2 like nucleolar associated transcriptional repressor Homo sapiens 29-32 26400780-3 2015 Here we report a noninvasive NIR-driven, temperature-sensitive DI-TSL (DOX/ICG-loaded temperature sensitive liposomes) co-encapsulating doxorubicin (DOX) and indocyanine green (ICG). Indocyanine Green 158-175 TSL Homo sapiens 66-69 26400780-3 2015 Here we report a noninvasive NIR-driven, temperature-sensitive DI-TSL (DOX/ICG-loaded temperature sensitive liposomes) co-encapsulating doxorubicin (DOX) and indocyanine green (ICG). Indocyanine Green 177-180 NOC2 like nucleolar associated transcriptional repressor Homo sapiens 29-32 26400780-3 2015 Here we report a noninvasive NIR-driven, temperature-sensitive DI-TSL (DOX/ICG-loaded temperature sensitive liposomes) co-encapsulating doxorubicin (DOX) and indocyanine green (ICG). Indocyanine Green 177-180 TSL Homo sapiens 66-69 26400780-7 2015 Furthermore, DI-TSL shows laser-controlled release of DOX in tumour, enhanced ICG and DOX retention by 7 times and 4 times compared with free drugs. Indocyanine Green 78-81 TSL Homo sapiens 16-19 26271413-8 2015 Moreover, by the of engagement of Wnt pathway agonist (LiCl) and antagonist (ICG 001) we demonstrate that DOX-TRF conjugate effectively reduces transcription of key genes involved in beta-catenin signaling transduction trial (Wnt3a, DVL-1, FZD-3, LRP5, beta-catenin, DKK2) and triggers morphology alternations of CML cells. Indocyanine Green 77-80 catenin beta 1 Homo sapiens 183-195 26271413-8 2015 Moreover, by the of engagement of Wnt pathway agonist (LiCl) and antagonist (ICG 001) we demonstrate that DOX-TRF conjugate effectively reduces transcription of key genes involved in beta-catenin signaling transduction trial (Wnt3a, DVL-1, FZD-3, LRP5, beta-catenin, DKK2) and triggers morphology alternations of CML cells. Indocyanine Green 77-80 Wnt family member 3A Homo sapiens 226-231 26271413-8 2015 Moreover, by the of engagement of Wnt pathway agonist (LiCl) and antagonist (ICG 001) we demonstrate that DOX-TRF conjugate effectively reduces transcription of key genes involved in beta-catenin signaling transduction trial (Wnt3a, DVL-1, FZD-3, LRP5, beta-catenin, DKK2) and triggers morphology alternations of CML cells. Indocyanine Green 77-80 dishevelled segment polarity protein 1 Homo sapiens 233-238 26271413-8 2015 Moreover, by the of engagement of Wnt pathway agonist (LiCl) and antagonist (ICG 001) we demonstrate that DOX-TRF conjugate effectively reduces transcription of key genes involved in beta-catenin signaling transduction trial (Wnt3a, DVL-1, FZD-3, LRP5, beta-catenin, DKK2) and triggers morphology alternations of CML cells. Indocyanine Green 77-80 frizzled class receptor 3 Homo sapiens 240-245 26271413-8 2015 Moreover, by the of engagement of Wnt pathway agonist (LiCl) and antagonist (ICG 001) we demonstrate that DOX-TRF conjugate effectively reduces transcription of key genes involved in beta-catenin signaling transduction trial (Wnt3a, DVL-1, FZD-3, LRP5, beta-catenin, DKK2) and triggers morphology alternations of CML cells. Indocyanine Green 77-80 LDL receptor related protein 5 Homo sapiens 247-251 26271413-8 2015 Moreover, by the of engagement of Wnt pathway agonist (LiCl) and antagonist (ICG 001) we demonstrate that DOX-TRF conjugate effectively reduces transcription of key genes involved in beta-catenin signaling transduction trial (Wnt3a, DVL-1, FZD-3, LRP5, beta-catenin, DKK2) and triggers morphology alternations of CML cells. Indocyanine Green 77-80 catenin beta 1 Homo sapiens 253-265 26271413-8 2015 Moreover, by the of engagement of Wnt pathway agonist (LiCl) and antagonist (ICG 001) we demonstrate that DOX-TRF conjugate effectively reduces transcription of key genes involved in beta-catenin signaling transduction trial (Wnt3a, DVL-1, FZD-3, LRP5, beta-catenin, DKK2) and triggers morphology alternations of CML cells. Indocyanine Green 77-80 dickkopf WNT signaling pathway inhibitor 2 Homo sapiens 267-271 24401807-0 2015 Comparison of Laser Doppler and Laser-Assisted Indocyanine Green Angiography Prediction of Flap Survival in a Novel Modification of the McFarlane Flap. Indocyanine Green 47-64 arachidonate 5-lipoxygenase activating protein Rattus norvegicus 91-95 26149724-10 2015 In conclusion, ICG distribution into the mouse fetus can be enhanced when used concomitantly with OATP or P-glycoprotein inhibitors. Indocyanine Green 15-18 solute carrier organic anion transporter family, member 1a6 Mus musculus 98-102 26081552-2 2015 PATIENTS AND METHODS: Two patients who were included in a protocol study evaluating the role of ICG in the detection of peritoneal metastases of colorectal origin (Protocol NCT-01995591) also had fluorescent LNs at exploration with a dedicated near-infrared camera system (Photodynamic Eye, PDE; Hamamatsu Photonics, Hamamatsu, Japan). Indocyanine Green 96-99 aldehyde dehydrogenase 7 family member A1 Homo sapiens 291-294 26168727-0 2015 In vivo photoacoustic imaging of cancer using indocyanine green-labeled monoclonal antibody targeting the epidermal growth factor receptor. Indocyanine Green 46-63 epidermal growth factor receptor Mus musculus 106-138 26168727-2 2015 The aim of this study was to evaluate the effectiveness of an anti-epidermal growth factor receptor (EGFR) monoclonal antibody (panitumumab; Pan) labeled with indocyanine green derivative (ICG-EG4-Sulfo-OSu), Pan-EG4-ICG, as a PA imaging probe to target cancer-associated EGFR. Indocyanine Green 159-176 epidermal growth factor receptor Mus musculus 62-99 26168727-2 2015 The aim of this study was to evaluate the effectiveness of an anti-epidermal growth factor receptor (EGFR) monoclonal antibody (panitumumab; Pan) labeled with indocyanine green derivative (ICG-EG4-Sulfo-OSu), Pan-EG4-ICG, as a PA imaging probe to target cancer-associated EGFR. Indocyanine Green 159-176 epidermal growth factor receptor Mus musculus 101-105 26168727-2 2015 The aim of this study was to evaluate the effectiveness of an anti-epidermal growth factor receptor (EGFR) monoclonal antibody (panitumumab; Pan) labeled with indocyanine green derivative (ICG-EG4-Sulfo-OSu), Pan-EG4-ICG, as a PA imaging probe to target cancer-associated EGFR. Indocyanine Green 189-192 epidermal growth factor receptor Mus musculus 62-99 26168727-2 2015 The aim of this study was to evaluate the effectiveness of an anti-epidermal growth factor receptor (EGFR) monoclonal antibody (panitumumab; Pan) labeled with indocyanine green derivative (ICG-EG4-Sulfo-OSu), Pan-EG4-ICG, as a PA imaging probe to target cancer-associated EGFR. Indocyanine Green 189-192 epidermal growth factor receptor Mus musculus 101-105 26168727-2 2015 The aim of this study was to evaluate the effectiveness of an anti-epidermal growth factor receptor (EGFR) monoclonal antibody (panitumumab; Pan) labeled with indocyanine green derivative (ICG-EG4-Sulfo-OSu), Pan-EG4-ICG, as a PA imaging probe to target cancer-associated EGFR. Indocyanine Green 189-192 epidermal growth factor receptor Mus musculus 272-276 24401807-0 2015 Comparison of Laser Doppler and Laser-Assisted Indocyanine Green Angiography Prediction of Flap Survival in a Novel Modification of the McFarlane Flap. Indocyanine Green 47-64 arachidonate 5-lipoxygenase activating protein Rattus norvegicus 146-150 24887978-1 2015 OBJECTIVE: To investigate the feasibility and efficacy of anatomical liver resection (ALR) guided by fused images comprising a macroscopic view and indocyanine green fluorescence imaging (fusion IGFI). Indocyanine Green 148-165 growth factor, augmenter of liver regeneration Homo sapiens 86-89 25771495-18 2015 CONCLUSIONS: Based on our pilot experience, NIR fluorescence imaging with ICG is an excellent and safe tracer modality for SLN mapping with a very high overall (96%) and bilateral (88%) detection rate. Indocyanine Green 74-77 sarcolipin Homo sapiens 123-126 25768079-16 2015 Moreover, ICG-99mTc-nanocolloid allows the administration of a 5-times lower injected dose of ICG (compared with ICG and ICG absorbed to human serum albumin) and can be injected up to 20 hours before surgery. Indocyanine Green 10-13 albumin Homo sapiens 143-156 25824139-5 2015 The activation of Wnt/beta-catenin is critical in the induction of angiogenesis by hucMSC-Ex, which could be reversed by beta-catenin inhibitor ICG-001. Indocyanine Green 144-147 Wnt family member 4 Homo sapiens 18-21 26015379-5 2015 PAI occurred in 3 of 5 cases in which indocyanine green videoangiography(ICG-VAG)was performed. Indocyanine Green 38-55 serpin family E member 1 Homo sapiens 0-3 26114045-4 2015 The poli-OCT signal was assessed in tissue-mimicking phantoms containing indocyanine green (ICG), an FDA approved small molecule that has not been previously imaged in vivo with PTOCT. Indocyanine Green 73-90 plexin A2 Mus musculus 9-12 26114045-4 2015 The poli-OCT signal was assessed in tissue-mimicking phantoms containing indocyanine green (ICG), an FDA approved small molecule that has not been previously imaged in vivo with PTOCT. Indocyanine Green 92-95 plexin A2 Mus musculus 9-12 26114045-5 2015 Then, the effects of in vivo blood flow and motion artifact were assessed and attenuated, and in vivo poli-OCT was demonstrated with both ICG and gold nanorods as contrast agents. Indocyanine Green 138-141 plexin A2 Mus musculus 107-110 26114045-7 2015 In phantoms containing biologically relevant concentrations of ICG (1 microg/ml), the poli-OCT signal was significantly greater than control phantoms (p<0.05), demonstrating sensitivity to small molecules. Indocyanine Green 63-66 plexin A2 Mus musculus 91-94 26114045-8 2015 Finally, in vivo poli-OCT of ICG identified the lymphatic vessels in a mouse ear, and also identified low concentrations (200 pM) of gold nanorods in subcutaneous injections at frame rates ten times faster than previously reported. Indocyanine Green 29-32 plexin A2 Mus musculus 22-25 25824139-5 2015 The activation of Wnt/beta-catenin is critical in the induction of angiogenesis by hucMSC-Ex, which could be reversed by beta-catenin inhibitor ICG-001. Indocyanine Green 144-147 catenin beta 1 Homo sapiens 22-34 25824139-5 2015 The activation of Wnt/beta-catenin is critical in the induction of angiogenesis by hucMSC-Ex, which could be reversed by beta-catenin inhibitor ICG-001. Indocyanine Green 144-147 catenin beta 1 Homo sapiens 121-133 25897700-10 2015 These results suggested that therapeutically targeting of the CBP/beta-catenin signaling pathway with ICG-001 can effectively reduce the CSC-like population and combination with cisplatin can effectively suppress the growth of NPC. Indocyanine Green 102-105 CREB binding protein Homo sapiens 62-65 25897700-10 2015 These results suggested that therapeutically targeting of the CBP/beta-catenin signaling pathway with ICG-001 can effectively reduce the CSC-like population and combination with cisplatin can effectively suppress the growth of NPC. Indocyanine Green 102-105 catenin beta 1 Homo sapiens 66-78 25528955-8 2015 En face SS OCT imaging of PCV eyes demonstrated the relationship between larger pigment epithelial detachments (PEDs) and small adjoining PEDs that correlated with the polypoidal lesions seen on indocyanine green angiography in all PCV eyes. Indocyanine Green 195-212 plexin A2 Homo sapiens 11-14 25766588-8 2015 Three asymptomatic young carriers of a TIMP3 mutation with otherwise normal findings on funduscopy and retinal imaging showed a characteristically reduced fluorescence on late-phase ICG-A images. Indocyanine Green 182-185 TIMP metallopeptidase inhibitor 3 Homo sapiens 39-44 25631666-0 2015 Investigating the role of human serum albumin protein pocket on the excited state dynamics of indocyanine green using shaped femtosecond laser pulses. Indocyanine Green 94-111 albumin Homo sapiens 32-45 25631666-2 2015 Shaped femtosecond laser pulses are used to probe the behavior of indocyanine green (ICG), the only Food and Drug Administration (FDA) approved near-infrared dye and photodynamic therapy agent, while free in solution and while confined inside the pocket of the human serum albumin (HSA) protein. Indocyanine Green 66-83 albumin Homo sapiens 267-294 25631666-2 2015 Shaped femtosecond laser pulses are used to probe the behavior of indocyanine green (ICG), the only Food and Drug Administration (FDA) approved near-infrared dye and photodynamic therapy agent, while free in solution and while confined inside the pocket of the human serum albumin (HSA) protein. Indocyanine Green 85-88 albumin Homo sapiens 267-294 26191083-6 2015 The small molecule inhibitor ICG-001 binds to CBP, but not to p300, and competitively inhibits the interaction of CBP with beta-catenin. Indocyanine Green 29-32 CREB binding protein Homo sapiens 46-49 26191083-6 2015 The small molecule inhibitor ICG-001 binds to CBP, but not to p300, and competitively inhibits the interaction of CBP with beta-catenin. Indocyanine Green 29-32 CREB binding protein Homo sapiens 114-117 26191083-6 2015 The small molecule inhibitor ICG-001 binds to CBP, but not to p300, and competitively inhibits the interaction of CBP with beta-catenin. Indocyanine Green 29-32 catenin beta 1 Homo sapiens 123-135 26191083-8 2015 RESULTS: We have compared the genome-wide effects on the transcriptome after treatment with ICG-001 (the specific CBP inhibitor) versus C646, a compound that competes with acetyl-coA for the Lys-coA binding pocket of both CBP and p300. Indocyanine Green 92-95 CREB binding protein Homo sapiens 114-117 25102195-1 2015 PURPOSE: To evaluate short-wavelength FAF as a parameter of retinal pigment epithelium function in eyes with acute symptomatic central serous chorioretinopathy after indocyanine green angiography-guided verteporfin photodynamic therapy with half-fluence rate. Indocyanine Green 166-183 ubiquitin specific peptidase 9 X-linked Homo sapiens 38-41 25173835-5 2015 RESULTS: Immunoblot analysis revealed that the expression of organic anion transporting polypeptide 1B3 (OATP1B3) and multidrug resistance p-glycoprotein (MDR)-3, as influx and efflux transporters, respectively, were significantly higher in ICG-accumulated HCC (ICG-high HCC) than in ICG-low HCC. Indocyanine Green 241-244 solute carrier organic anion transporter family member 1B3 Homo sapiens 61-103 25173835-5 2015 RESULTS: Immunoblot analysis revealed that the expression of organic anion transporting polypeptide 1B3 (OATP1B3) and multidrug resistance p-glycoprotein (MDR)-3, as influx and efflux transporters, respectively, were significantly higher in ICG-accumulated HCC (ICG-high HCC) than in ICG-low HCC. Indocyanine Green 241-244 solute carrier organic anion transporter family member 1B3 Homo sapiens 105-112 25173835-5 2015 RESULTS: Immunoblot analysis revealed that the expression of organic anion transporting polypeptide 1B3 (OATP1B3) and multidrug resistance p-glycoprotein (MDR)-3, as influx and efflux transporters, respectively, were significantly higher in ICG-accumulated HCC (ICG-high HCC) than in ICG-low HCC. Indocyanine Green 241-244 ATP binding cassette subfamily B member 4 Homo sapiens 118-161 25173835-6 2015 ICG was fluorescently observed in the pseudoglands and bile canaliculi abundantly expressing MDR3. Indocyanine Green 0-3 ATP binding cassette subfamily B member 4 Homo sapiens 93-97 25173835-8 2015 CONCLUSIONS: The intratumoral expression of MDR3, a key efflux transporter of ICG, affected the prognosis of patients with HCC, presumably by altering the lipid composition of the lipid bilayers. Indocyanine Green 78-81 ATP binding cassette subfamily B member 4 Homo sapiens 44-48 25102195-2 2015 METHODS: A retrospective review over a period of 1 year of short-wavelength FAF images of 15 consecutive patients treated with half-fluence rate (25 J/cm) indocyanine green angiography-guided verteporfin photodynamic therapy due to acute symptomatic central serous chorioretinopathy was performed. Indocyanine Green 155-172 ubiquitin specific peptidase 9 X-linked Homo sapiens 76-79 25514782-0 2015 Immunotargeted photodynamic therapy for cholesteatoma: in vitro results with anti-EGFR-coated indocyanine green nanocapsules. Indocyanine Green 94-111 epidermal growth factor receptor Homo sapiens 82-86 24667036-5 2015 Moreover, exposure to dexamethasone in combination with oncostatin M promptly induced further maturation of the cells through the acquisition of additional functions (i.e., ability to store glycogen and uptake of indocyanine green). Indocyanine Green 213-230 oncostatin M Homo sapiens 56-68 25012166-8 2015 ICG-001 inhibited renal expression of multiple RAS genes in vivo and abolished the expression of other Wnt/beta-catenin target genes. Indocyanine Green 0-3 catenin (cadherin associated protein), beta 1 Mus musculus 107-119 25012166-9 2015 Moreover, ICG-001 therapy restored expression of nephrin, podocin, and Wilms" tumor 1, attenuated interstitial myofibroblast activation, repressed matrix expression, and inhibited renal inflammation and fibrosis. Indocyanine Green 10-13 nephrosis 1, nephrin Mus musculus 49-56 25012166-9 2015 Moreover, ICG-001 therapy restored expression of nephrin, podocin, and Wilms" tumor 1, attenuated interstitial myofibroblast activation, repressed matrix expression, and inhibited renal inflammation and fibrosis. Indocyanine Green 10-13 nephrosis 2, podocin Mus musculus 58-65 25514782-1 2015 HYPOTHESIS: The objective was to test the hypothesis that immunotargeted photodynamic therapy (IT-PDT) using anti-epithelial growth factor receptor (EGFR)-coated indocyanine green (ICG) nanocapsules would selectively kill cholesteatoma-derived keratinocytes while sparing middle ear-derived mucosa cells in vitro. Indocyanine Green 162-179 epidermal growth factor receptor Homo sapiens 109-147 25514782-1 2015 HYPOTHESIS: The objective was to test the hypothesis that immunotargeted photodynamic therapy (IT-PDT) using anti-epithelial growth factor receptor (EGFR)-coated indocyanine green (ICG) nanocapsules would selectively kill cholesteatoma-derived keratinocytes while sparing middle ear-derived mucosa cells in vitro. Indocyanine Green 162-179 epidermal growth factor receptor Homo sapiens 149-153 25514782-1 2015 HYPOTHESIS: The objective was to test the hypothesis that immunotargeted photodynamic therapy (IT-PDT) using anti-epithelial growth factor receptor (EGFR)-coated indocyanine green (ICG) nanocapsules would selectively kill cholesteatoma-derived keratinocytes while sparing middle ear-derived mucosa cells in vitro. Indocyanine Green 181-184 epidermal growth factor receptor Homo sapiens 109-147 25514782-1 2015 HYPOTHESIS: The objective was to test the hypothesis that immunotargeted photodynamic therapy (IT-PDT) using anti-epithelial growth factor receptor (EGFR)-coated indocyanine green (ICG) nanocapsules would selectively kill cholesteatoma-derived keratinocytes while sparing middle ear-derived mucosa cells in vitro. Indocyanine Green 181-184 epidermal growth factor receptor Homo sapiens 149-153 25514782-4 2015 METHODS: ICG nanocapsules coated with anti-EGFR were synthesized and applied to cholesteatoma-derived keratinocytes and middle ear mucosa cells in vitro. Indocyanine Green 9-12 epidermal growth factor receptor Homo sapiens 43-47 25082960-0 2014 The CREB-binding protein inhibitor ICG-001 suppresses pancreatic cancer growth. Indocyanine Green 35-38 CREB binding protein Homo sapiens 4-24 25251028-4 2014 Melatonin also inhibited PrP (106-126)-induced neurotoxicity and the inhibition attenuated by treatment of beta-catenin inhibitor ICG-001. Indocyanine Green 130-133 catenin beta 1 Homo sapiens 107-119 25082960-8 2014 DNA microarrays performed on PDAC cells in the context of ICG-001 treatment revealed ICG-001 altered the expression of several genes with well-established roles in DNA replication and cell-cycle progression, including direct actions on SKP2 and CDKN1A. Indocyanine Green 85-88 S-phase kinase associated protein 2 Homo sapiens 236-240 25082960-8 2014 DNA microarrays performed on PDAC cells in the context of ICG-001 treatment revealed ICG-001 altered the expression of several genes with well-established roles in DNA replication and cell-cycle progression, including direct actions on SKP2 and CDKN1A. Indocyanine Green 85-88 cyclin dependent kinase inhibitor 1A Homo sapiens 245-251 25082960-9 2014 ICG-001 also significantly prolonged survival in an in vivo orthotopic xenograft model of PDAC, indicating ICG-001 or derived compounds that disrupt CBP activity are potentially useful small-molecule therapeutics for pancreatic cancer. Indocyanine Green 0-3 CREB binding protein Homo sapiens 149-152 25082960-9 2014 ICG-001 also significantly prolonged survival in an in vivo orthotopic xenograft model of PDAC, indicating ICG-001 or derived compounds that disrupt CBP activity are potentially useful small-molecule therapeutics for pancreatic cancer. Indocyanine Green 107-110 CREB binding protein Homo sapiens 149-152 24975284-8 2014 This review will discuss the discovery of the specific CBP/catenin antagonist ICG-001 and the ongoing clinical development of the second generation CBP/catenin antagonist PRI-724. Indocyanine Green 78-81 CREB binding protein Homo sapiens 55-58 25426379-8 2014 The intensity of indocyanine green fluorescence significantly decreased earlier in the bFGF group (P < 0.05). Indocyanine Green 17-34 fibroblast growth factor 2 Rattus norvegicus 87-91 21671037-9 2014 LPG and ICG fluorescence were useful methods for SLN detection in patients with previous BAS, being able to confirm lymph flow before operation. Indocyanine Green 8-11 sarcolipin Homo sapiens 49-52 32261858-2 2014 The objective of the present study was to develop a novel, simple and powerful nanotherapeutic system for the pH- and near-infrared (NIR)-responsive chemothermal treatment of cancer cells by co-loading coralyne and indocyanine green (ICG) into the adenine DNA (poly(A))-functionalized MSN. Indocyanine Green 215-232 moesin Homo sapiens 285-288 25191833-3 2014 Here, we prepared a human serum albumin (HSA) conjugated with indocyanine green (ICG) as a PA contrast agent allowing enhanced permeability and retention effect for sensitive tumor imaging. Indocyanine Green 62-79 albumin Mus musculus 26-39 25191833-3 2014 Here, we prepared a human serum albumin (HSA) conjugated with indocyanine green (ICG) as a PA contrast agent allowing enhanced permeability and retention effect for sensitive tumor imaging. Indocyanine Green 81-84 albumin Mus musculus 26-39 24566742-7 2014 METHODS: Bovine serum albumin was conjugated to indocyanine green or the succinimidyl ester CF 790 to form a pasty mixture, which was used to coat the front ends of endoscopic clips. Indocyanine Green 48-65 albumin Homo sapiens 22-29 25048331-8 2014 Circulating TIMP-1 correlated significantly with indocyanine green clearance (r = -0.44, p < 0.0001), Child Turcotte score (r = 0.50, p < 0.0001), HVPG (r = 0.40, p < 0.0001), mean arterial pressure (r = -0.29, p = 0.008), and systemic vascular resistance (r = -0.23, p = 0.03). Indocyanine Green 49-66 TIMP metallopeptidase inhibitor 1 Homo sapiens 12-18 24977327-7 2014 Furthermore, Gal-4 sensitizes PDAC cells to the Wnt inhibitor ICG-001, which interferes with the interaction between CREB binding protein (CBP) and beta-catenin. Indocyanine Green 62-65 galectin 4 Homo sapiens 13-18 24977327-7 2014 Furthermore, Gal-4 sensitizes PDAC cells to the Wnt inhibitor ICG-001, which interferes with the interaction between CREB binding protein (CBP) and beta-catenin. Indocyanine Green 62-65 CREB binding protein Homo sapiens 117-137 24977327-7 2014 Furthermore, Gal-4 sensitizes PDAC cells to the Wnt inhibitor ICG-001, which interferes with the interaction between CREB binding protein (CBP) and beta-catenin. Indocyanine Green 62-65 CREB binding protein Homo sapiens 139-142 24977327-7 2014 Furthermore, Gal-4 sensitizes PDAC cells to the Wnt inhibitor ICG-001, which interferes with the interaction between CREB binding protein (CBP) and beta-catenin. Indocyanine Green 62-65 catenin beta 1 Homo sapiens 148-160 24632333-7 2014 A significant reduction in the inflammatory mediators; tumor necrosis factor-alpha, nitric oxide and 5-lipoxygenase was reported, however the level of cyclooxygenase-2 (COX-2) was significantly elevated after ICG/PDT treatment. Indocyanine Green 209-212 prostaglandin-endoperoxide synthase 2 Mus musculus 151-167 24632333-7 2014 A significant reduction in the inflammatory mediators; tumor necrosis factor-alpha, nitric oxide and 5-lipoxygenase was reported, however the level of cyclooxygenase-2 (COX-2) was significantly elevated after ICG/PDT treatment. Indocyanine Green 209-212 prostaglandin-endoperoxide synthase 2 Mus musculus 169-174 24961210-12 2014 CONCLUSION: We have demonstrated the efficacy of polymeric nano-structured constructs loaded with ICG, and functionalized with the monoclonal antibodies, as thernaostic materials for targted molecular NIR imaging of the HER2 receptor overexpression on ovarian cancer cells, and photothermal destruction of these cells. Indocyanine Green 98-101 erb-b2 receptor tyrosine kinase 2 Homo sapiens 220-224 24859437-5 2014 The uptake of antibody conjugated ICG-DOX-PLGA nanoparticles (AIDNP) was enhanced in SKOV-3 (HER-2 overexpressing cell lines) compared to their non-conjugated counterparts (ICG-DOX-PLGA nanoparticles (IDNP)). Indocyanine Green 34-37 erb-b2 receptor tyrosine kinase 2 Homo sapiens 93-98 24819961-3 2014 We report strategy and characterization of a novel small-molecule inhibitor, ICG-001, known to affect Wnt signaling by disrupting beta-catenin-CREB binding protein interactions. Indocyanine Green 77-80 catenin beta 1 Homo sapiens 130-142 24819961-3 2014 We report strategy and characterization of a novel small-molecule inhibitor, ICG-001, known to affect Wnt signaling by disrupting beta-catenin-CREB binding protein interactions. Indocyanine Green 77-80 CREB binding protein Homo sapiens 143-163 24582865-15 2014 CONCLUSIONS: NIR fluorescence imaging with intracervical ICG injection using the robotic platform has a high bilateral SLN detection rate and appears favorable to using blue dye alone and/or other modalities. Indocyanine Green 57-60 sarcolipin Homo sapiens 119-122 23728349-8 2014 Here, we report that selective disruption of the CBP/beta- and gamma-catenin interactions using ICG-001 leads to differentiation of pre-B ALL cells and loss of self-renewal capacity. Indocyanine Green 96-99 CREB binding protein Homo sapiens 49-52 23728349-8 2014 Here, we report that selective disruption of the CBP/beta- and gamma-catenin interactions using ICG-001 leads to differentiation of pre-B ALL cells and loss of self-renewal capacity. Indocyanine Green 96-99 catenin beta 1 Homo sapiens 53-76 23728349-11 2014 CBP mutations have been recently identified in a significant percentage of ALL patients, however, almost all of the identified mutations reported occur C-terminal to the binding site for ICG-001. Indocyanine Green 187-190 CREB binding protein Homo sapiens 0-3 24254203-3 2014 Microscopic examinations, gene expression profile analysis, and immunohistochemical staining were performed for HCCs, which showed ICG fluorescence in the cancerous tissues (cancerous-type fluorescence), and HCCs showed fluorescence only in the surrounding non-cancerous liver parenchyma (rim-type fluorescence). Indocyanine Green 131-134 holocytochrome c synthase Homo sapiens 112-116 24310791-1 2014 PURPOSE: This study was performed to validate a newly developed sentinel lymph node (SLN) targeting tracer, indocyanine green-neomannosyl human serum albumin (ICG:MSA), and a thoracoscopic version of the intraoperative color and fluorescence imaging system (ICFIS) for lung cancer SLN mapping. Indocyanine Green 108-125 albumin Rattus norvegicus 144-157 23957775-0 2014 Intraoperative indocyanine green video-angiography as an aid to the microsurgical treatment of spinal vascular malformations. Indocyanine Green 15-32 activation induced cytidine deaminase Homo sapiens 57-60 23957775-2 2014 Intra-operative Indocyanine Green (ICG) video-angiography (ICG-VA) has become an established aid to cerebrovascular surgery. Indocyanine Green 16-33 activation induced cytidine deaminase Homo sapiens 93-96 23957775-2 2014 Intra-operative Indocyanine Green (ICG) video-angiography (ICG-VA) has become an established aid to cerebrovascular surgery. Indocyanine Green 35-38 activation induced cytidine deaminase Homo sapiens 93-96 23957775-2 2014 Intra-operative Indocyanine Green (ICG) video-angiography (ICG-VA) has become an established aid to cerebrovascular surgery. Indocyanine Green 59-62 activation induced cytidine deaminase Homo sapiens 93-96 24531912-2 2014 METHODS: In this study, hydrophobic fluorescent dyes ICG-Der-01 was entrapped into the N-succinyl-N"-octyl chitosan (SOC) micelles to form the near infrared absorbing dyes SOC-ICG-Der-01 and SOC-ICG-Der-01 mediated near infrared laser (SOC-ICG-Der-01/NIR) thermotherapy was combined with Ad-ERbeta gene therapy to regress colon cancer in vivo. Indocyanine Green 53-56 estrogen receptor 2 Homo sapiens 291-297 24651519-9 2014 Intraoperative indocyanine green fluorescence lymphography revealed lymph stasis in intima/medial in AAA. Indocyanine Green 15-32 AAA1 Homo sapiens 101-104 24688815-5 2014 ICG at concentration of 25 muM (which is about 4 times higher than the highest concentration of ICG in the brain applied in in-vivo human studies) is not neurotoxic in the cell culture. Indocyanine Green 0-3 latexin Homo sapiens 27-30 24458201-9 2014 CONCLUSION: The results provided novel interpretations of the ICG hyperfluorescence and its association with OCT characteristics of the cystoid spaces in DMO. Indocyanine Green 62-65 plexin A2 Homo sapiens 109-112 24571629-4 2014 In parallel, the fluorescent near-infrared (NIR) dye indocyanine green (ICG) was conjugated to the protein human serum albumin (HSA) by electrostatic and hydrophobic interactions. Indocyanine Green 53-70 albumin Mus musculus 113-126 24571629-4 2014 In parallel, the fluorescent near-infrared (NIR) dye indocyanine green (ICG) was conjugated to the protein human serum albumin (HSA) by electrostatic and hydrophobic interactions. Indocyanine Green 72-75 albumin Mus musculus 113-126 24785457-9 2014 The high expression of Nodal in HCC was correlated with tumor size (chi(2) = 15.318, P = 0.000), alpha-fetoprotein (chi(2) = 3.850, P = 0.049), indocyanine green retention rate at 15 minutes (chi(2) = 6.590, P = 0.010), and invasion and metastasis (chi(2) = 17.824, P = 0.000). Indocyanine Green 144-161 nodal growth differentiation factor Homo sapiens 23-28 24254203-4 2014 RESULTS: ICG fluorescence imaging enabled identification of 273 of 276 (99%) HCCs in the resected specimens. Indocyanine Green 9-12 holocytochrome c synthase Homo sapiens 77-81 24254203-7 2014 The ratio of the gene and protein expression levels in the cancerous to non-cancerous tissues for Na(+)/taurocholate cotransporting polypeptide (NTCP) and organic anion-transporting polypeptide 8 (OATP8), which are associated with portal uptake of ICG by hepatocytes that tended to be higher in the HCCs that showed cancerous-type fluorescence than in those that showed rim-type fluorescence. Indocyanine Green 248-251 solute carrier family 10 member 1 Homo sapiens 98-143 24254203-7 2014 The ratio of the gene and protein expression levels in the cancerous to non-cancerous tissues for Na(+)/taurocholate cotransporting polypeptide (NTCP) and organic anion-transporting polypeptide 8 (OATP8), which are associated with portal uptake of ICG by hepatocytes that tended to be higher in the HCCs that showed cancerous-type fluorescence than in those that showed rim-type fluorescence. Indocyanine Green 248-251 solute carrier organic anion transporter family member 1B3 Homo sapiens 155-195 24254203-8 2014 CONCLUSIONS: Preserved portal uptake of ICG in differentiated HCC cells by NTCP and OATP8 with concomitant biliary excretion disorders causes accumulation of ICG in the cancerous tissues after preoperative intravenous administration. Indocyanine Green 40-43 solute carrier family 10 member 1 Homo sapiens 75-79 24254203-8 2014 CONCLUSIONS: Preserved portal uptake of ICG in differentiated HCC cells by NTCP and OATP8 with concomitant biliary excretion disorders causes accumulation of ICG in the cancerous tissues after preoperative intravenous administration. Indocyanine Green 40-43 solute carrier organic anion transporter family member 1B3 Homo sapiens 84-89 24254203-8 2014 CONCLUSIONS: Preserved portal uptake of ICG in differentiated HCC cells by NTCP and OATP8 with concomitant biliary excretion disorders causes accumulation of ICG in the cancerous tissues after preoperative intravenous administration. Indocyanine Green 158-161 solute carrier family 10 member 1 Homo sapiens 75-79 24254203-8 2014 CONCLUSIONS: Preserved portal uptake of ICG in differentiated HCC cells by NTCP and OATP8 with concomitant biliary excretion disorders causes accumulation of ICG in the cancerous tissues after preoperative intravenous administration. Indocyanine Green 158-161 solute carrier organic anion transporter family member 1B3 Homo sapiens 84-89 24895813-7 2014 Four patients (control, 1; MNC, 1; CD34+, 2) started at over 18% ICG-R15 but can be overturned after PVE. Indocyanine Green 65-68 CD34 molecule Homo sapiens 35-39 23595610-5 2014 Developing HuH-7 and HepG2 tumors were confirmed that preferentially took up the ICG in 24 h after ICG was administered to mice via tail vein. Indocyanine Green 81-84 MIR7-3 host gene Homo sapiens 11-16 23595610-5 2014 Developing HuH-7 and HepG2 tumors were confirmed that preferentially took up the ICG in 24 h after ICG was administered to mice via tail vein. Indocyanine Green 99-102 MIR7-3 host gene Homo sapiens 11-16 23595610-11 2014 CONCLUSIONS: ICG is preferentially taken up by HuH-7 and HepG2 human hepatoma cell line tumors. Indocyanine Green 13-16 MIR7-3 host gene Homo sapiens 47-52 24011522-1 2013 PURPOSE: To evaluate the effect of choroidal vascular hyperpermeability, as determined using indocyanine green angiography (ICGA), on the outcome of anti-vascular endothelial growth factor (VEGF) treatment for polypoidal choroidal vasculopathy (PCV). Indocyanine Green 93-110 vascular endothelial growth factor A Homo sapiens 149-188 25300946-8 2014 In non-hypoxic conditions, both increased the adhesive properties of RPE cells to fibronectin, ICG more than trypan blue (p = 0.001). Indocyanine Green 95-98 fibronectin 1 Homo sapiens 82-93 24231576-10 2013 Laser-assisted indocyanine green angiography was used to confirm perfusion of the lymph node flap. Indocyanine Green 15-32 arachidonate 5-lipoxygenase activating protein Rattus norvegicus 93-97 24231576-15 2013 After indocyanine green administration, fluorescence was observed throughout the lymph node flap and within the venous pedicle of the flap. Indocyanine Green 6-23 arachidonate 5-lipoxygenase activating protein Rattus norvegicus 92-96 24231576-15 2013 After indocyanine green administration, fluorescence was observed throughout the lymph node flap and within the venous pedicle of the flap. Indocyanine Green 6-23 arachidonate 5-lipoxygenase activating protein Rattus norvegicus 134-138 24011522-1 2013 PURPOSE: To evaluate the effect of choroidal vascular hyperpermeability, as determined using indocyanine green angiography (ICGA), on the outcome of anti-vascular endothelial growth factor (VEGF) treatment for polypoidal choroidal vasculopathy (PCV). Indocyanine Green 93-110 vascular endothelial growth factor A Homo sapiens 190-194 23522603-13 2013 ICG alone can be useful for SLN imaging during lung cancer surgery. Indocyanine Green 0-3 sarcolipin Rattus norvegicus 28-31 24346856-0 2013 Enhanced fluorescence diffuse optical tomography with indocyanine green-encapsulating liposomes targeted to receptors for vascular endothelial growth factor in tumor vasculature. Indocyanine Green 54-71 vascular endothelial growth factor A Mus musculus 122-156 23515171-5 2013 Indocyanine green fluorescence (ICG) was used for objective assessment of the IMF quality by a near-infrared camera system (Photodynamic Eye( ), Hamamatsu Photonics, Japan). Indocyanine Green 0-17 MyoD family inhibitor Homo sapiens 78-81 24284098-8 2013 The conjugating of ICG-PEBBLE to anti-EGFR was found to be more effective in inhibiting VEGF and in increasing caspase-3 compared to free ICG-PEBBLE, but there were no other preferential PDT efficacy. Indocyanine Green 19-22 vascular endothelial growth factor A Mus musculus 88-92 24284098-8 2013 The conjugating of ICG-PEBBLE to anti-EGFR was found to be more effective in inhibiting VEGF and in increasing caspase-3 compared to free ICG-PEBBLE, but there were no other preferential PDT efficacy. Indocyanine Green 19-22 caspase 3 Mus musculus 111-120 24284098-8 2013 The conjugating of ICG-PEBBLE to anti-EGFR was found to be more effective in inhibiting VEGF and in increasing caspase-3 compared to free ICG-PEBBLE, but there were no other preferential PDT efficacy. Indocyanine Green 138-141 epidermal growth factor receptor Mus musculus 38-42 24006937-7 2013 The NIR image of gastrointestinal transit of ICG conjugated PEG-CS-PTH NPs supports this significant finding. Indocyanine Green 45-48 parathyroid hormone Homo sapiens 67-70 23790404-10 2013 CONCLUSIONS: NIR-guided SLN identification with ICG was safe and feasible in this initial dose-escalation trial. Indocyanine Green 48-51 sarcolipin Homo sapiens 24-27 23790404-11 2013 ICG doses greater than 1000 mug yielded nearly 90% intrathoracic SLN visualization, with the presence or absence of metastatic disease in the SLN directly correlating with final nodal status of the lymphadenectomy specimen. Indocyanine Green 0-3 sarcolipin Homo sapiens 65-68 23901349-11 2013 The small molecule ICG-001, in clinical trial, is a specific inhibitor of CBP-mediated WNT signaling, and previous studies have suggested that p300 is required for the activity of ICG-001. Indocyanine Green 19-22 CREB binding protein Homo sapiens 74-77 23901349-11 2013 The small molecule ICG-001, in clinical trial, is a specific inhibitor of CBP-mediated WNT signaling, and previous studies have suggested that p300 is required for the activity of ICG-001. Indocyanine Green 19-22 E1A binding protein p300 Homo sapiens 143-147 23901349-11 2013 The small molecule ICG-001, in clinical trial, is a specific inhibitor of CBP-mediated WNT signaling, and previous studies have suggested that p300 is required for the activity of ICG-001. Indocyanine Green 180-183 E1A binding protein p300 Homo sapiens 143-147 23901349-12 2013 However, we report that ICG-001 maintains full activity against CBP-mediated WNT signaling in p300-deficient cell lines, including the butyrate-resistance line HCT-R. Indocyanine Green 24-27 CREB binding protein Homo sapiens 64-67 23901349-12 2013 However, we report that ICG-001 maintains full activity against CBP-mediated WNT signaling in p300-deficient cell lines, including the butyrate-resistance line HCT-R. Indocyanine Green 24-27 E1A binding protein p300 Homo sapiens 94-98 24284098-0 2013 Photodynamic therapeutic effect of indocyanine green entrapped in polymeric nanoparticles and their anti-EGFR-conjugate in skin cancer in CD1 mice. Indocyanine Green 35-52 epidermal growth factor receptor Mus musculus 105-109 24284098-0 2013 Photodynamic therapeutic effect of indocyanine green entrapped in polymeric nanoparticles and their anti-EGFR-conjugate in skin cancer in CD1 mice. Indocyanine Green 35-52 CD1 antigen complex Mus musculus 138-141 24284098-3 2013 The study objective is to investigate the PDT effect of free ICG-PEBBLE and its Anti-EGFR conjugate. Indocyanine Green 61-64 epidermal growth factor receptor Mus musculus 85-89 24284098-5 2013 RESULTS: PDT using ICG-PEBBLE or ICG-PEBBLE-Anti-EGFR decreased skin tumor sizes. Indocyanine Green 33-36 epidermal growth factor receptor Mus musculus 49-53 24284098-7 2013 CONCLUSION: The present study indicated the effectiveness of PDT using ICG-PEBBLE or ICG-PEBBLE-Anti-EGFR as an inhibitor modality for tumor size, apoptosis, angiogenesis and tumor inflammation. Indocyanine Green 85-88 epidermal growth factor receptor Mus musculus 101-105 24284098-8 2013 The conjugating of ICG-PEBBLE to anti-EGFR was found to be more effective in inhibiting VEGF and in increasing caspase-3 compared to free ICG-PEBBLE, but there were no other preferential PDT efficacy. Indocyanine Green 19-22 epidermal growth factor receptor Mus musculus 38-42 24069374-0 2013 The small molecule Wnt signaling modulator ICG-001 improves contractile function in chronically infarcted rat myocardium. Indocyanine Green 43-46 Wnt family member 2 Rattus norvegicus 19-22 24069374-3 2013 The small molecule ICG-001 modulates Wnt signaling and increased the expression of genes beneficial for cardiac regeneration in epicardial cells. Indocyanine Green 19-22 Wnt family member 2 Rattus norvegicus 37-40 23726228-8 2013 Moreover, immunohistofluorescence analysis confirmed that the PEI-D-GlcNAc-ICG/siRNA complex specifically colocalized with HSCs, which are desmin-positive cells, in fibrotic liver tissues. Indocyanine Green 75-78 desmin Mus musculus 139-145 23825054-9 2013 The effects of rpl1b-Delta and of either paromomycin or tRNA(Arg(ICG)) on CGA decoding are additive, suggesting that the rpl1b-Delta mutant suppresses CGA inhibition by means other than increased acceptance of tRNA(Arg(ICG)). Indocyanine Green 65-68 ribosomal 60S subunit protein L1B Saccharomyces cerevisiae S288C 121-126 23825054-9 2013 The effects of rpl1b-Delta and of either paromomycin or tRNA(Arg(ICG)) on CGA decoding are additive, suggesting that the rpl1b-Delta mutant suppresses CGA inhibition by means other than increased acceptance of tRNA(Arg(ICG)). Indocyanine Green 219-222 ribosomal 60S subunit protein L1B Saccharomyces cerevisiae S288C 121-126 23736260-5 2013 Blocking beta-catenin-CBP interaction with the small molecule ICG-001 and small-interfering RNAs against beta-catenin, CBP or Mll abrogate hyperproliferation and H3K4 tri-methylation, and induce differentiation of cultured tumour propagating cells into acini-like structures. Indocyanine Green 62-65 catenin beta 1 Homo sapiens 9-21 23736260-5 2013 Blocking beta-catenin-CBP interaction with the small molecule ICG-001 and small-interfering RNAs against beta-catenin, CBP or Mll abrogate hyperproliferation and H3K4 tri-methylation, and induce differentiation of cultured tumour propagating cells into acini-like structures. Indocyanine Green 62-65 CREB binding protein Homo sapiens 22-25 23515171-5 2013 Indocyanine green fluorescence (ICG) was used for objective assessment of the IMF quality by a near-infrared camera system (Photodynamic Eye( ), Hamamatsu Photonics, Japan). Indocyanine Green 32-35 MyoD family inhibitor Homo sapiens 78-81 23348864-7 2013 Indocyanine green angiography hypofluorescent LCD were larger and more reflective on SD-OCT than indocyanine green angiography hyperfluorescent LCD. Indocyanine Green 0-17 plexin A2 Homo sapiens 88-91 23373441-6 2013 Further differentiation of these spheroid cells in the presence of the hepatocyte growth factor, oncostatin M, and dexamethasone produced a highly enriched population of cells exhibiting characteristics of early hepatocytes, including glycogen storage, indocyanine green uptake, and synthesis of urea and albumin. Indocyanine Green 253-270 oncostatin M Homo sapiens 97-109 23287901-3 2013 The purpose of this study is to evaluate whether a semiquantitative analysis of indocyanine green (ICG) videoangiography could be useful in predicting postoperative hyperperfusion after STA-MCA anastomosis. Indocyanine Green 80-97 GCY Homo sapiens 186-189 23600922-7 2013 Panitumumab-ICG conjugates with short PEG linkers were able to detect human epidermal growth factor receptor 1 (EGFR)-positive tumors with high tumor-to-background ratios (15.8 and 6.9 for EGFR positive tumor-to-negative tumor and tumor-to-liver ratios, respectively, at 3 d postinjection). Indocyanine Green 12-15 epidermal growth factor receptor Homo sapiens 76-110 23600922-7 2013 Panitumumab-ICG conjugates with short PEG linkers were able to detect human epidermal growth factor receptor 1 (EGFR)-positive tumors with high tumor-to-background ratios (15.8 and 6.9 for EGFR positive tumor-to-negative tumor and tumor-to-liver ratios, respectively, at 3 d postinjection). Indocyanine Green 12-15 epidermal growth factor receptor Homo sapiens 112-116 23600922-7 2013 Panitumumab-ICG conjugates with short PEG linkers were able to detect human epidermal growth factor receptor 1 (EGFR)-positive tumors with high tumor-to-background ratios (15.8 and 6.9 for EGFR positive tumor-to-negative tumor and tumor-to-liver ratios, respectively, at 3 d postinjection). Indocyanine Green 12-15 epidermal growth factor receptor Homo sapiens 189-193 23769286-3 2013 This study aimed to evaluate the efficacy of PDT with indocyanine green (ICG) through the investigation of TP53, HER-2 and TOP2A genes signals as breast cancer gene markers by interphase fluorescence in situ hybridization (nuc-FISH). Indocyanine Green 54-71 tumor protein p53 Homo sapiens 107-111 23769286-3 2013 This study aimed to evaluate the efficacy of PDT with indocyanine green (ICG) through the investigation of TP53, HER-2 and TOP2A genes signals as breast cancer gene markers by interphase fluorescence in situ hybridization (nuc-FISH). Indocyanine Green 54-71 erb-b2 receptor tyrosine kinase 2 Homo sapiens 113-118 23769286-3 2013 This study aimed to evaluate the efficacy of PDT with indocyanine green (ICG) through the investigation of TP53, HER-2 and TOP2A genes signals as breast cancer gene markers by interphase fluorescence in situ hybridization (nuc-FISH). Indocyanine Green 54-71 DNA topoisomerase II alpha Homo sapiens 123-128 23769286-3 2013 This study aimed to evaluate the efficacy of PDT with indocyanine green (ICG) through the investigation of TP53, HER-2 and TOP2A genes signals as breast cancer gene markers by interphase fluorescence in situ hybridization (nuc-FISH). Indocyanine Green 73-76 tumor protein p53 Homo sapiens 107-111 23769286-3 2013 This study aimed to evaluate the efficacy of PDT with indocyanine green (ICG) through the investigation of TP53, HER-2 and TOP2A genes signals as breast cancer gene markers by interphase fluorescence in situ hybridization (nuc-FISH). Indocyanine Green 73-76 erb-b2 receptor tyrosine kinase 2 Homo sapiens 113-118 23769286-3 2013 This study aimed to evaluate the efficacy of PDT with indocyanine green (ICG) through the investigation of TP53, HER-2 and TOP2A genes signals as breast cancer gene markers by interphase fluorescence in situ hybridization (nuc-FISH). Indocyanine Green 73-76 DNA topoisomerase II alpha Homo sapiens 123-128 23287901-3 2013 The purpose of this study is to evaluate whether a semiquantitative analysis of indocyanine green (ICG) videoangiography could be useful in predicting postoperative hyperperfusion after STA-MCA anastomosis. Indocyanine Green 99-102 GCY Homo sapiens 186-189 23287901-11 2013 CONCLUSIONS: These findings suggest that semiquantitative analysis of ICG videoangiography is helpful in predicting occurrence of hyperperfusion after STA-MCA anastomosis in patients with occlusive carotid artery diseases. Indocyanine Green 70-73 GCY Homo sapiens 151-154 23316072-6 2013 Activation of beta-catenin/p300-dependent gene expression using the compound ICG-001 accelerated epithelial repair in vitro and in murine models. Indocyanine Green 77-80 catenin (cadherin associated protein), beta 1 Mus musculus 14-26 22200990-11 2013 Other than preoperatively diagnosed foci, ICG fluorography visualized 35 new lesions, including 6 HCCs, 2 dysplastic nodules and 27 non-neoplastic lesions, such as bile plugs and cysts. Indocyanine Green 42-45 holocytochrome c synthase Homo sapiens 98-102 22200990-13 2013 CONCLUSIONS: Indocyanine green fluorography is useful to detect HCCs; however, attention should be paid to the fact that HCCs may be occasionally overlooked by this imaging method and that lesions detected by this method are not always neoplastic lesions. Indocyanine Green 13-30 holocytochrome c synthase Homo sapiens 64-68 23316072-6 2013 Activation of beta-catenin/p300-dependent gene expression using the compound ICG-001 accelerated epithelial repair in vitro and in murine models. Indocyanine Green 77-80 E1A binding protein p300 Mus musculus 27-31 23149278-5 2013 Treatment of the injured rats with the beta-catenin inhibitor ICG-001 (oral gavage at 200mg/kg/day for 8days, commenced at day 2 post injury) enhanced COL2A1 gene expression (by qRT-PCR) and increased proportion of cartilage tissue (by histological analysis), but decreased level of osterix expression and amount of bone tissue, at the injury site by day 10 post-injury (n=8, P<0.01 compared to vehicle controls). Indocyanine Green 62-65 catenin beta 1 Rattus norvegicus 39-51 23149278-5 2013 Treatment of the injured rats with the beta-catenin inhibitor ICG-001 (oral gavage at 200mg/kg/day for 8days, commenced at day 2 post injury) enhanced COL2A1 gene expression (by qRT-PCR) and increased proportion of cartilage tissue (by histological analysis), but decreased level of osterix expression and amount of bone tissue, at the injury site by day 10 post-injury (n=8, P<0.01 compared to vehicle controls). Indocyanine Green 62-65 collagen type II alpha 1 chain Rattus norvegicus 151-157 23149278-5 2013 Treatment of the injured rats with the beta-catenin inhibitor ICG-001 (oral gavage at 200mg/kg/day for 8days, commenced at day 2 post injury) enhanced COL2A1 gene expression (by qRT-PCR) and increased proportion of cartilage tissue (by histological analysis), but decreased level of osterix expression and amount of bone tissue, at the injury site by day 10 post-injury (n=8, P<0.01 compared to vehicle controls). Indocyanine Green 62-65 Sp7 transcription factor Rattus norvegicus 283-290 23149278-6 2013 Consistently, in vitro studies with bone marrow stromal cells from normal rats showed that beta-catenin inhibitor ICG-001 dose dependently inhibited expression of Wnt target genes Cyclin D1 and survivin (P<0.01). Indocyanine Green 114-117 catenin beta 1 Rattus norvegicus 91-103 23149278-6 2013 Consistently, in vitro studies with bone marrow stromal cells from normal rats showed that beta-catenin inhibitor ICG-001 dose dependently inhibited expression of Wnt target genes Cyclin D1 and survivin (P<0.01). Indocyanine Green 114-117 Wnt family member 2 Rattus norvegicus 163-166 23149278-6 2013 Consistently, in vitro studies with bone marrow stromal cells from normal rats showed that beta-catenin inhibitor ICG-001 dose dependently inhibited expression of Wnt target genes Cyclin D1 and survivin (P<0.01). Indocyanine Green 114-117 cyclin D1 Rattus norvegicus 180-189 23437332-3 2013 METHODOLOGY/PRINCIPAL FINDINGS: We investigated the suitability of dendritic polyglycerol sulfates (dPGS), conjugated with a hydrophilic version of the indocyanine green label with 6 sulfonate groups (6S-ICG) to monitor sites of inflammation using an experimental mouse model of allergic asthma. Indocyanine Green 152-169 Kinesin heavy chain Drosophila melanogaster 100-104 23203799-7 2013 Both F-TrCP-Ecad and ICG-001 blocked TGF-beta1-induced Smad3/beta-catenin and Smad reporter activity in C1.1 cells, suggesting that TGF-beta1-induced EMT depends on beta-catenin binding to Smad3, but not LEF-1 downstream of Smad3, through canonical Wnt. Indocyanine Green 21-24 transforming growth factor, beta 1 Mus musculus 37-46 23203799-7 2013 Both F-TrCP-Ecad and ICG-001 blocked TGF-beta1-induced Smad3/beta-catenin and Smad reporter activity in C1.1 cells, suggesting that TGF-beta1-induced EMT depends on beta-catenin binding to Smad3, but not LEF-1 downstream of Smad3, through canonical Wnt. Indocyanine Green 21-24 SMAD family member 3 Mus musculus 55-60 23203799-7 2013 Both F-TrCP-Ecad and ICG-001 blocked TGF-beta1-induced Smad3/beta-catenin and Smad reporter activity in C1.1 cells, suggesting that TGF-beta1-induced EMT depends on beta-catenin binding to Smad3, but not LEF-1 downstream of Smad3, through canonical Wnt. Indocyanine Green 21-24 catenin (cadherin associated protein), beta 1 Mus musculus 61-73 23203799-7 2013 Both F-TrCP-Ecad and ICG-001 blocked TGF-beta1-induced Smad3/beta-catenin and Smad reporter activity in C1.1 cells, suggesting that TGF-beta1-induced EMT depends on beta-catenin binding to Smad3, but not LEF-1 downstream of Smad3, through canonical Wnt. Indocyanine Green 21-24 phosphatidylinositol-5-phosphate 4-kinase, type II, beta Mus musculus 104-108 23203799-7 2013 Both F-TrCP-Ecad and ICG-001 blocked TGF-beta1-induced Smad3/beta-catenin and Smad reporter activity in C1.1 cells, suggesting that TGF-beta1-induced EMT depends on beta-catenin binding to Smad3, but not LEF-1 downstream of Smad3, through canonical Wnt. Indocyanine Green 21-24 transforming growth factor, beta 1 Mus musculus 132-141 23203799-10 2013 Inhibition of beta-catenin by either F-TrCP-Ecad or ICG-001 abolished LiCl-induced TOP-flash, but not TGF-beta1-induced Smad reporter, activity in J774 cells. Indocyanine Green 52-55 catenin (cadherin associated protein), beta 1 Mus musculus 14-26 24022718-8 2013 Expression of Bax was upregulated after all dye exposures, except BBG; ICG had the highest Bax expression (p < 0.01). Indocyanine Green 71-74 BCL2 associated X, apoptosis regulator Homo sapiens 14-17 24022718-8 2013 Expression of Bax was upregulated after all dye exposures, except BBG; ICG had the highest Bax expression (p < 0.01). Indocyanine Green 71-74 BCL2 associated X, apoptosis regulator Homo sapiens 91-94 23256223-0 2004 Anti-human sperm protein 17 monoclonal antibody-indocyanine green derivative 02 Optical fluorescence imaging is increasingly used to monitor biological functions of specific targets in small animals (1-3). Indocyanine Green 48-65 sperm autoantigenic protein 17 Homo sapiens 11-27 23256223-14 2004 (13) explored the overexpression of Sp17 in malignant tumors as a molecular biomarker for tumor imaging by coupling anti-human Sp17 monoclonal antibody with ICG derivative 02 (anti-Sp17-ICG-Der-02). Indocyanine Green 157-160 sperm autoantigenic protein 17 Homo sapiens 36-40 23098218-3 2012 Our objective was to evaluate whether the FDA-approved near-infrared compound indocyanine green (ICG) can be used as a probe substrate of P-gp. Indocyanine Green 78-95 PGP Canis lupus familiaris 138-142 23098218-3 2012 Our objective was to evaluate whether the FDA-approved near-infrared compound indocyanine green (ICG) can be used as a probe substrate of P-gp. Indocyanine Green 97-100 PGP Canis lupus familiaris 138-142 23098218-4 2012 We also characterized the interaction of ICG with another efflux transporter, the breast cancer resistance protein (BCRP). Indocyanine Green 41-44 ATP binding cassette subfamily G member 2 Canis lupus familiaris 82-114 23098218-4 2012 We also characterized the interaction of ICG with another efflux transporter, the breast cancer resistance protein (BCRP). Indocyanine Green 41-44 ATP binding cassette subfamily G member 2 Canis lupus familiaris 116-120 23098218-5 2012 We evaluated ICG accumulation and transport in MDCK cells overexpressing P-gp or BCRP (MDCK-MDR1 and MDCK-BCRP, respectively) compared to control MDCK cells, in the presence or the absence of transporter inhibitors. Indocyanine Green 13-16 PGP Canis lupus familiaris 73-77 23098218-5 2012 We evaluated ICG accumulation and transport in MDCK cells overexpressing P-gp or BCRP (MDCK-MDR1 and MDCK-BCRP, respectively) compared to control MDCK cells, in the presence or the absence of transporter inhibitors. Indocyanine Green 13-16 ATP binding cassette subfamily G member 2 Canis lupus familiaris 81-85 23098218-8 2012 The efflux ratio for ICG in MDCK-MDR1 cells was 6.8-fold greater than in control cells. Indocyanine Green 21-24 ATP binding cassette subfamily B member 1 Canis lupus familiaris 28-37 23098218-9 2012 P-gp inhibition attenuated ICG efflux from MDR1-MDCK cells, and their effects in those cells were greater than in control MDCK cells. Indocyanine Green 27-30 PGP Canis lupus familiaris 0-4 23098218-12 2012 The findings from this pilot study suggest that near-infrared imaging using ICG as the probe substrate should be further characterized as a methodology for in vivo evaluation of P-gp activity. Indocyanine Green 76-79 PGP Canis lupus familiaris 178-182 23287322-0 2012 Intraoperative assessment of STA-MCA bypass patency using near-infrared indocyanine green video-angiography: a preliminary study. Indocyanine Green 72-89 GCY Homo sapiens 29-32 23043088-11 2012 ICG-001 and XAV939, inhibitors of the WNT/beta-catenin pathway, reduced the proliferative effect of miR-154. Indocyanine Green 0-3 catenin beta 1 Homo sapiens 42-54 23043088-11 2012 ICG-001 and XAV939, inhibitors of the WNT/beta-catenin pathway, reduced the proliferative effect of miR-154. Indocyanine Green 0-3 microRNA 154 Homo sapiens 100-107 22833164-4 2012 There are several studies suggesting that patients who do not respond satisfactorily to intravitreal anti-VEGF treatment are suffering from PCV which can be detected by indocyanine green angiography. Indocyanine Green 169-186 vascular endothelial growth factor A Homo sapiens 106-110 20670344-0 2012 Indocyanine green increases light-induced oxidative stress, senescence, and matrix metalloproteinases 1 and 3 in human RPE cells. Indocyanine Green 0-17 matrix metallopeptidase 1 Homo sapiens 76-109 20670344-11 2012 Effects on the expression of ROS, SA beta-Gal, and MMP-1 and 3 were, depending on the ICG dose, significantly increased when cells were pre-incubated with ICG and then illuminated. Indocyanine Green 86-89 matrix metallopeptidase 1 Homo sapiens 51-62 20670344-11 2012 Effects on the expression of ROS, SA beta-Gal, and MMP-1 and 3 were, depending on the ICG dose, significantly increased when cells were pre-incubated with ICG and then illuminated. Indocyanine Green 155-158 matrix metallopeptidase 1 Homo sapiens 51-62 22659344-6 2012 The hepatocyte-like cells generated by FOXA2 and HNF1alpha transduction exerted various hepatocyte functions including albumin and urea secretion, and the uptake of indocyanine green and low density lipoprotein. Indocyanine Green 165-182 forkhead box A2 Homo sapiens 39-44 22659344-6 2012 The hepatocyte-like cells generated by FOXA2 and HNF1alpha transduction exerted various hepatocyte functions including albumin and urea secretion, and the uptake of indocyanine green and low density lipoprotein. Indocyanine Green 165-182 HNF1 homeobox A Homo sapiens 49-58 22499061-4 2012 RESULTS: Preoperative PDE observation was able to demonstrate several lymph flows running to the bilateral inguinal areas from the perianal area immediately after ICG injection in 13 of the patients (92.9%). Indocyanine Green 163-166 aldehyde dehydrogenase 7 family member A1 Homo sapiens 22-25 22350230-6 2012 Intraoperative SLN detection was performed using endoscopically injected indocyanine green lymphography for comparison. Indocyanine Green 73-90 sarcolipin Canis lupus familiaris 15-18 22325306-7 2012 Furthermore, it is surprising to find that 50 muM of indocyanine green in combination with light at 60 J/cm(2) and 4 Gy of X-ray radiation astonishingly killed cancer cells and reduced the percentage of viable cancer cells to be 3.42%. Indocyanine Green 53-70 latexin Homo sapiens 46-49 22670083-1 2012 We report two cases of choroidal neurofibromatosis, detected with the aid of indocyanine green angiography (ICGA) in patients with neurofibromatosis (NF)-1, otherwise having obscure findings based on ophthalmoscopy and fluoresceine angiography (FA). Indocyanine Green 77-94 neurofibromin 1 Homo sapiens 131-155 22241478-3 2012 We previously demonstrated that ICG-001, a small molecule specific inhibitor of the beta-catenin/CBP (but not beta-catenin/p300) interaction, ameliorates and reverses pulmonary fibrosis and inhibits TGF-beta1-mediated alpha-smooth muscle actin (alpha-SMA) and collagen induction in AEC. Indocyanine Green 32-35 catenin beta 1 Homo sapiens 84-96 22270359-6 2012 Silencing of beta-catenin or treatment with the small molecule inhibitor, ICG-001, inhibits leptin-induced EMT, invasion, and tumorsphere formation. Indocyanine Green 74-77 leptin Homo sapiens 92-98 22241478-3 2012 We previously demonstrated that ICG-001, a small molecule specific inhibitor of the beta-catenin/CBP (but not beta-catenin/p300) interaction, ameliorates and reverses pulmonary fibrosis and inhibits TGF-beta1-mediated alpha-smooth muscle actin (alpha-SMA) and collagen induction in AEC. Indocyanine Green 32-35 CREB binding protein Homo sapiens 97-100 22241478-3 2012 We previously demonstrated that ICG-001, a small molecule specific inhibitor of the beta-catenin/CBP (but not beta-catenin/p300) interaction, ameliorates and reverses pulmonary fibrosis and inhibits TGF-beta1-mediated alpha-smooth muscle actin (alpha-SMA) and collagen induction in AEC. Indocyanine Green 32-35 transforming growth factor beta 1 Homo sapiens 199-208 22002955-0 2012 Synthesis and characterization of bovine serum albumin-coated nanocapsules loaded with indocyanine green as potential multifunctional nanoconstructs. Indocyanine Green 87-104 albumin Homo sapiens 41-54 22400137-0 2004 Quenched indocyanine green-anti-prostate-specific membrane antigen antibody J591 Optical fluorescence imaging is increasingly used to monitor biological functions of specific targets in small animals (1-3). Indocyanine Green 9-26 folate hydrolase 1 Homo sapiens 32-66 22400137-28 2004 (19) prepared quenched ICG-anti-PSMA antibody J591 (ICG-J591) for in vivo NIR imaging of PSMA-positive tumors in mice. Indocyanine Green 23-26 folate hydrolase 1 Homo sapiens 32-36 22400137-28 2004 (19) prepared quenched ICG-anti-PSMA antibody J591 (ICG-J591) for in vivo NIR imaging of PSMA-positive tumors in mice. Indocyanine Green 23-26 folate hydrolase 1 Homo sapiens 89-93 22002955-1 2012 We have synthesized and characterized bovine serum albumin (BSA)-coated polymeric nanocapsules (NCs) loaded with indocyanine green (ICG), an FDA-approved near infrared chromophore. Indocyanine Green 113-130 albumin Homo sapiens 45-58 21882198-4 2012 METHODS: Forty-seven patients were subject to injection of indocyanine green for navigation to the SLN based on fluorescent dye retention detection. Indocyanine Green 59-76 sarcolipin Homo sapiens 99-102 22002955-1 2012 We have synthesized and characterized bovine serum albumin (BSA)-coated polymeric nanocapsules (NCs) loaded with indocyanine green (ICG), an FDA-approved near infrared chromophore. Indocyanine Green 132-135 albumin Homo sapiens 45-58 22040928-3 2012 In this study we have assessed the extent to which liver function, assessed by the plasma disappearance rate of indocyanine green (PDR(ICG)), is affected in patients with severe burns. Indocyanine Green 112-129 PDR Homo sapiens 131-139 22373990-7 2012 The fluorescent dye indocyanine green was injected intravenously before and after conversion of a perforator flap with an intact skin bridge into an islanded perforator flap. Indocyanine Green 20-37 arachidonate 5-lipoxygenase activating protein Homo sapiens 109-113 22373990-7 2012 The fluorescent dye indocyanine green was injected intravenously before and after conversion of a perforator flap with an intact skin bridge into an islanded perforator flap. Indocyanine Green 20-37 arachidonate 5-lipoxygenase activating protein Homo sapiens 169-173 22130469-0 2012 Breast cancer sentinel lymph node mapping using near infrared guided indocyanine green and indocyanine green--human serum albumin in comparison with gamma emitting radioactive colloid tracer. Indocyanine Green 91-108 albumin Homo sapiens 122-129 22130469-1 2012 AIMS: Recently, a novel method of using near infrared (NIR) guided indocyanine green (ICG) and ICG conjugated with human serum albumin (ICG:HSA) for sentinel lymph node biopsy (SLNB) of breast cancer patients has shown true potential. Indocyanine Green 95-98 albumin Homo sapiens 127-134 22130469-1 2012 AIMS: Recently, a novel method of using near infrared (NIR) guided indocyanine green (ICG) and ICG conjugated with human serum albumin (ICG:HSA) for sentinel lymph node biopsy (SLNB) of breast cancer patients has shown true potential. Indocyanine Green 95-98 albumin Homo sapiens 127-134 21963099-2 2012 Furthermore, dose optimization of indocyanine green adsorbed to human serum albumin was performed. Indocyanine Green 34-51 albumin Homo sapiens 70-83 22510481-6 2012 METHODS: We describe the use of activatable, near infrared fluorescence-labeled AlexaFluor680 (Alexa680) conjugated panitumumab (Pan) targeted against human epidermal growth factor receptor (EGFR) (Pan-Alexa680) and Indocyanine Green (ICG) conjugated trastuzumab (Tra) targeted against human epidermal growth factor receptor type 2 (HER2) (Tra-ICG) were synthesized and evaluated in cells in vitro and in an orthotopic breast cancer mouse model in vivo. Indocyanine Green 216-233 epidermal growth factor receptor Homo sapiens 157-189 21963099-4 2012 In addition, intraoperative imaging was performed after peritumoral injection of 1.6 mL of 500, 750, or 1000 muM of indocyanine green adsorbed to human serum albumin. Indocyanine Green 116-133 albumin Homo sapiens 152-165 21963099-7 2012 CONCLUSION: This study demonstrates feasibility and accuracy of sentinel lymph node mapping using indocyanine green adsorbed to human serum albumin. Indocyanine Green 98-115 albumin Homo sapiens 134-147 21963099-8 2012 Considering safety, cost, and pharmacy preferences, an indocyanine green adsorbed to human serum albumin concentration of 500 muM appears optimal for sentinel lymph node mapping in vulvar cancer. Indocyanine Green 55-72 albumin Homo sapiens 91-104 22510481-6 2012 METHODS: We describe the use of activatable, near infrared fluorescence-labeled AlexaFluor680 (Alexa680) conjugated panitumumab (Pan) targeted against human epidermal growth factor receptor (EGFR) (Pan-Alexa680) and Indocyanine Green (ICG) conjugated trastuzumab (Tra) targeted against human epidermal growth factor receptor type 2 (HER2) (Tra-ICG) were synthesized and evaluated in cells in vitro and in an orthotopic breast cancer mouse model in vivo. Indocyanine Green 216-233 epidermal growth factor receptor Homo sapiens 191-195 22510481-6 2012 METHODS: We describe the use of activatable, near infrared fluorescence-labeled AlexaFluor680 (Alexa680) conjugated panitumumab (Pan) targeted against human epidermal growth factor receptor (EGFR) (Pan-Alexa680) and Indocyanine Green (ICG) conjugated trastuzumab (Tra) targeted against human epidermal growth factor receptor type 2 (HER2) (Tra-ICG) were synthesized and evaluated in cells in vitro and in an orthotopic breast cancer mouse model in vivo. Indocyanine Green 235-238 epidermal growth factor receptor Homo sapiens 157-189 22510481-6 2012 METHODS: We describe the use of activatable, near infrared fluorescence-labeled AlexaFluor680 (Alexa680) conjugated panitumumab (Pan) targeted against human epidermal growth factor receptor (EGFR) (Pan-Alexa680) and Indocyanine Green (ICG) conjugated trastuzumab (Tra) targeted against human epidermal growth factor receptor type 2 (HER2) (Tra-ICG) were synthesized and evaluated in cells in vitro and in an orthotopic breast cancer mouse model in vivo. Indocyanine Green 235-238 epidermal growth factor receptor Homo sapiens 191-195 22977676-0 2012 Indocyanine green near-infrared laser angiography predicts timing for the division of a forehead flap. Indocyanine Green 0-17 arachidonate 5-lipoxygenase activating protein Homo sapiens 97-101 22977676-8 2012 CONCLUSION: Near-infrared laser angiography with indocyanine green can assess perfusion status of the entire flap and inform the decision to divide the flap in an objective manner. Indocyanine Green 49-66 arachidonate 5-lipoxygenase activating protein Homo sapiens 109-113 23308299-7 2012 Laser-assisted indocyanine green imaging confirmed adequate flap perfusion on the basis of a single left deep inferior epigastric perforator. Indocyanine Green 15-32 arachidonate 5-lipoxygenase activating protein Homo sapiens 60-64 23308299-11 2012 Laser-assisted indocyanine green angiography facilitated perforator selection and provided intraoperative assessment of flap perfusion. Indocyanine Green 15-32 arachidonate 5-lipoxygenase activating protein Homo sapiens 120-124 23056632-8 2012 In addition, the time of indocyanine green elimination, the percentage of glycogen synthetic cells, and the expressions of ALB, G-6-P, CK-8, CK-18 and CYP450-3A1 in HGF+DMSO-treated group were higher than in any other group. Indocyanine Green 25-42 hepatocyte growth factor Homo sapiens 165-168 23308088-5 2012 FGFR activation-induced cell proliferation and survival were also inhibited by the compound ICG-001, a small molecule inhibitor of beta-catenin-CREB Binding Protein (CBP) in hepatoblasts, further indicating a CBP-dependent regulatory mechanism of beta-catenin activity. Indocyanine Green 92-95 CREB binding protein Mus musculus 131-164 23308088-5 2012 FGFR activation-induced cell proliferation and survival were also inhibited by the compound ICG-001, a small molecule inhibitor of beta-catenin-CREB Binding Protein (CBP) in hepatoblasts, further indicating a CBP-dependent regulatory mechanism of beta-catenin activity. Indocyanine Green 92-95 CREB binding protein Mus musculus 166-169 23308088-5 2012 FGFR activation-induced cell proliferation and survival were also inhibited by the compound ICG-001, a small molecule inhibitor of beta-catenin-CREB Binding Protein (CBP) in hepatoblasts, further indicating a CBP-dependent regulatory mechanism of beta-catenin activity. Indocyanine Green 92-95 CREB binding protein Mus musculus 209-212 23308088-5 2012 FGFR activation-induced cell proliferation and survival were also inhibited by the compound ICG-001, a small molecule inhibitor of beta-catenin-CREB Binding Protein (CBP) in hepatoblasts, further indicating a CBP-dependent regulatory mechanism of beta-catenin activity. Indocyanine Green 92-95 catenin (cadherin associated protein), beta 1 Mus musculus 131-143 22152386-7 2011 Meanwhile, 40% and 30% cells were positive by ICG uptake assay after BMP2 and BMP9 induction. Indocyanine Green 46-49 bone morphogenetic protein 2 Homo sapiens 69-73 21905207-3 2011 As a first step of our proof-of-concept, we characterized high-speed PAFC capability to monitor the clearance of three dyes (Indocyanine Green [ICG], Methylene Blue [MB], and Trypan Blue [TB]) in an animal model in vivo and in real time. Indocyanine Green 125-142 PAFC Homo sapiens 69-73 21905207-3 2011 As a first step of our proof-of-concept, we characterized high-speed PAFC capability to monitor the clearance of three dyes (Indocyanine Green [ICG], Methylene Blue [MB], and Trypan Blue [TB]) in an animal model in vivo and in real time. Indocyanine Green 144-147 PAFC Homo sapiens 69-73 22152386-7 2011 Meanwhile, 40% and 30% cells were positive by ICG uptake assay after BMP2 and BMP9 induction. Indocyanine Green 46-49 growth differentiation factor 2 Homo sapiens 78-82 21163547-10 2011 ICG is transported by OATP1B3 and NTCP. Indocyanine Green 0-3 solute carrier organic anion transporter family member 1B3 Homo sapiens 22-29 21740058-0 2011 Targeted, activatable, in vivo fluorescence imaging of prostate-specific membrane antigen (PSMA) positive tumors using the quenched humanized J591 antibody-indocyanine green (ICG) conjugate. Indocyanine Green 156-173 folate hydrolase 1 Homo sapiens 91-95 21740058-0 2011 Targeted, activatable, in vivo fluorescence imaging of prostate-specific membrane antigen (PSMA) positive tumors using the quenched humanized J591 antibody-indocyanine green (ICG) conjugate. Indocyanine Green 175-178 folate hydrolase 1 Homo sapiens 91-95 21740058-4 2011 In this study, we successfully synthesized an activatable monoclonal antibody-fluorophore conjugate consisting of a humanized anti-Prostate-Specific Membrane Antigen (PSMA) antibody (J591) linked to an indocyanine green (ICG) derivative. Indocyanine Green 221-224 folate hydrolase 1 Homo sapiens 126-165 21740058-4 2011 In this study, we successfully synthesized an activatable monoclonal antibody-fluorophore conjugate consisting of a humanized anti-Prostate-Specific Membrane Antigen (PSMA) antibody (J591) linked to an indocyanine green (ICG) derivative. Indocyanine Green 221-224 folate hydrolase 1 Homo sapiens 167-171 21163547-10 2011 ICG is transported by OATP1B3 and NTCP. Indocyanine Green 0-3 solute carrier family 10 member 1 Homo sapiens 34-38 21163547-11 2011 CONCLUSIONS: The transporter specificity of (99m)Tc-mebrofenin and ICG partially overlaps as both compounds are transported by OATP1B3. Indocyanine Green 67-70 solute carrier organic anion transporter family member 1B3 Homo sapiens 127-134 21163547-12 2011 (99m)Tc-mebrofenin is also taken up by OATP1B1, whereas ICG is additionally transported by NTCP. Indocyanine Green 56-59 solute carrier family 10 member 1 Homo sapiens 91-95 21498148-2 2011 The objective of this study was to evaluate the feasibility of performing SLN biopsies using a fluorescence method with indocyanine green (ICG) and a near-infrared camera in combination with conventional blue dye and radioisotope methods in patients with malignant melanoma of the skin. Indocyanine Green 120-137 sarcolipin Homo sapiens 74-77 21366930-3 2011 A near infrared fluorescence dye, ICG-Der-02, was covalently linked to anti-Sp17 for in vivo imaging. Indocyanine Green 34-37 sperm autoantigenic protein 17 Homo sapiens 76-80 21498148-2 2011 The objective of this study was to evaluate the feasibility of performing SLN biopsies using a fluorescence method with indocyanine green (ICG) and a near-infrared camera in combination with conventional blue dye and radioisotope methods in patients with malignant melanoma of the skin. Indocyanine Green 139-142 sarcolipin Homo sapiens 74-77 21498148-7 2011 SLN biopsy guided by indocyanine green fluorescence is a promising procedure in patients with cutaneous melanoma, especially those with a poor flow of radioactive tracer substance. Indocyanine Green 21-38 sarcolipin Homo sapiens 0-3 19774415-3 2010 The aim of this study was to investigate the feasibility of lateral region SN biopsy by means of indocyanine green (ICG) visualized with a near-infrared camera system (Photodynamic Eye, PDE). Indocyanine Green 116-119 aldehyde dehydrogenase 7 family member A1 Homo sapiens 186-189 20660310-5 2010 ICG-001 selectively blocks the beta-catenin/CBP interaction without interfering with the beta-catenin/p300 interaction. Indocyanine Green 0-3 catenin beta 1 Homo sapiens 31-43 20660310-5 2010 ICG-001 selectively blocks the beta-catenin/CBP interaction without interfering with the beta-catenin/p300 interaction. Indocyanine Green 0-3 CREB binding protein Homo sapiens 44-47 20660310-6 2010 We report here that ICG-001 (5 mg/kg per day) significantly inhibits beta-catenin signaling and attenuates bleomycin-induced lung fibrosis in mice, while concurrently preserving the epithelium. Indocyanine Green 20-23 catenin (cadherin associated protein), beta 1 Mus musculus 69-81 20092330-5 2010 We further studied the specificity of tumor cell targeting using three carcinoma cell lines with different levels of EGFR expression and investigated the photothermal effects of ICG containing nanocapsules on EGFR-rich tumor cells. Indocyanine Green 178-181 epidermal growth factor receptor Homo sapiens 209-213 20204839-6 2010 ICG angiography clearly demonstrated the bypass blood flow from the anastomosed STA to the cortical vessels including arteries, capillaries, and veins in both MD and non-MD. Indocyanine Green 0-3 GCY Homo sapiens 80-83 21158719-10 2011 Combined treatment with imatinib mesylate (IM) and ICG-001 significantly inhibited colony formation in sorted CD34(+) CML progenitors (survivin(+)/gamma-catenin(high)/beta-catenin(low)) isolated from one BC and one AP patient resistant to IM. Indocyanine Green 51-54 CD34 molecule Homo sapiens 110-114 21158719-10 2011 Combined treatment with imatinib mesylate (IM) and ICG-001 significantly inhibited colony formation in sorted CD34(+) CML progenitors (survivin(+)/gamma-catenin(high)/beta-catenin(low)) isolated from one BC and one AP patient resistant to IM. Indocyanine Green 51-54 catenin beta 1 Homo sapiens 167-179 21158719-11 2011 Therefore, we believe that the ability of ICG-001 to block both the CBP/gamma-catenin interaction and the CBP/beta-catenin interaction may have clinical significance in cancers in which gamma-catenin plays a significant transcriptional role. Indocyanine Green 42-45 CREB binding protein Homo sapiens 68-71 21158719-11 2011 Therefore, we believe that the ability of ICG-001 to block both the CBP/gamma-catenin interaction and the CBP/beta-catenin interaction may have clinical significance in cancers in which gamma-catenin plays a significant transcriptional role. Indocyanine Green 42-45 CREB binding protein Homo sapiens 106-109 21158719-11 2011 Therefore, we believe that the ability of ICG-001 to block both the CBP/gamma-catenin interaction and the CBP/beta-catenin interaction may have clinical significance in cancers in which gamma-catenin plays a significant transcriptional role. Indocyanine Green 42-45 catenin beta 1 Homo sapiens 110-122 21073171-0 2010 Improved speciation characteristics of PEGylated indocyanine green-labeled Panitumumab: revisiting the solution and spectroscopic properties of a near-infrared emitting anti-HER1 antibody for optical imaging of cancer. Indocyanine Green 49-66 epidermal growth factor receptor Homo sapiens 174-178 21073171-1 2010 A water-soluble amine-reactive PEGylated analogue of near-infrared emitting dye indocyanine green (5) was synthesized and used to label the anti-HER1 antibody panitumumab (Vectibix) at various equivalents. Indocyanine Green 80-97 epidermal growth factor receptor Homo sapiens 145-149 21187501-6 2010 RESULTS: In univariate analysis, GPS 0 patients had significantly better preoperative the retention rate of indocyanine green at 15 minutes (ICGR15) (p=0.0418), Child-Pugh classification (p = 0.0075) and model for end-stage liver disease score (p = 0.0007) than did GPS 1 patients. Indocyanine Green 108-125 G protein pathway suppressor 1 Homo sapiens 266-271 20934154-4 2010 METHODS: We evaluated the bypass blood flow in 13 MD and 21 non-MD patients during STA-MCA anastomosis by means of ICG angiography with injection of ICG into the anastomosed STA. Indocyanine Green 149-152 GCY Homo sapiens 174-177 20934154-7 2010 RESULTS: ICG angiography demonstrated bypass blood flow from the anastomosed STA to the cortical vessels in all patients. Indocyanine Green 9-12 GCY Homo sapiens 77-80 19774415-6 2010 RESULTS: With PDE, the lymph nodes and lymph vessels that received ICG appeared as shining fluorescent spots and streams in the fluorescence image. Indocyanine Green 67-70 aldehyde dehydrogenase 7 family member A1 Homo sapiens 14-17 19384784-15 2009 Both fluorescein and ICG video-angiography provide adequate temporal resolution and vascular flow examination leading to easier RAP staging and identification of the anastomosis. Indocyanine Green 21-24 LDL receptor related protein associated protein 1 Homo sapiens 128-131 19732329-2 2009 Interest in this method has been renewed following the development of finger pulse densitometry for noninvasive estimation of the ICG plasma disappearance rate (PDR). Indocyanine Green 130-133 PDR Homo sapiens 161-164 20641614-13 2004 to develop an imaging probe for cancer by complexing ICG to Tra (Tra-ICG) (4). Indocyanine Green 53-56 T cell receptor alpha locus Homo sapiens 60-63 20641614-13 2004 to develop an imaging probe for cancer by complexing ICG to Tra (Tra-ICG) (4). Indocyanine Green 53-56 T cell receptor alpha locus Homo sapiens 65-72 20641812-14 2004 to develop an imaging probe for cancer by complexing ICG to Dac (Dac-ICG) (4). Indocyanine Green 53-56 dachshund family transcription factor 1 Mus musculus 65-72 18290338-8 2008 Our study results showed: Fe3O4 particles at a size range of 10 approximately 30 nm can be heated well by an AEM field at a rate of 18 degrees C/wt%-minute; the fluorescence of ICG was extensively enhanced by NGPs; LHRH-coated gold nanoparticles provided as much cancer specificity as LHRH alone. Indocyanine Green 177-180 gonadotropin releasing hormone 1 Homo sapiens 215-219 19668539-9 2009 Adjustment of the PDT spot size to include the detectable by ICG feeding complex might be an additional option in order to close the subfoveal CNV and might be considered as an alternative to intravitreal injection of anti-VEGF in selected cases where anti-VEGF treatment is not available. Indocyanine Green 61-64 vascular endothelial growth factor A Homo sapiens 257-261 18492850-10 2008 PPP1R11, RPS15A, and MTG1 were the most stable among ICG tested. Indocyanine Green 53-56 protein phosphatase 1 regulatory inhibitor subunit 11 Bos taurus 0-7 18492850-10 2008 PPP1R11, RPS15A, and MTG1 were the most stable among ICG tested. Indocyanine Green 53-56 mitochondrial ribosome associated GTPase 1 Bos taurus 21-25 18520071-5 2008 Multidrug resistance-associated protein (MRP) 4 substrates/inhibitors including methotrexate, indomethacin, taurocholic acid and indocyanine green significantly inhibited [3H]PGE1 uptake. Indocyanine Green 129-146 ATP binding cassette subfamily C member 4 Rattus norvegicus 0-47 18290338-8 2008 Our study results showed: Fe3O4 particles at a size range of 10 approximately 30 nm can be heated well by an AEM field at a rate of 18 degrees C/wt%-minute; the fluorescence of ICG was extensively enhanced by NGPs; LHRH-coated gold nanoparticles provided as much cancer specificity as LHRH alone. Indocyanine Green 177-180 gonadotropin releasing hormone 1 Homo sapiens 285-289 18290338-9 2008 Combining these properties in one entity, i.e., LHRH/ICG linked, gold-coated Fe3O4 nanoparticles, can be a tumor-specific nano-agent for optical detection and electro-magnetically induced hyperthermia for breast cancer. Indocyanine Green 53-56 gonadotropin releasing hormone 1 Homo sapiens 48-52 19126960-3 2008 We developed ICG-N-hydroxysulfosuccinimide ester (ICG-sulfo-OSu) and 3-ICG-acyl-1,3-thiazolidine-2-thione (ICG-ATT) as infrared fluorescent-labeling reagents, and anti-human carcinoembryonic antigen (CEA) antibody and MUC1 antibody were labeled with the ICG-derivatives. Indocyanine Green 13-16 CEA cell adhesion molecule 3 Homo sapiens 174-198 19126960-3 2008 We developed ICG-N-hydroxysulfosuccinimide ester (ICG-sulfo-OSu) and 3-ICG-acyl-1,3-thiazolidine-2-thione (ICG-ATT) as infrared fluorescent-labeling reagents, and anti-human carcinoembryonic antigen (CEA) antibody and MUC1 antibody were labeled with the ICG-derivatives. Indocyanine Green 13-16 CEA cell adhesion molecule 3 Homo sapiens 200-203 19126960-6 2008 The immunofluorescence studies suggested that the intensity of the infrared fluorescence of the ICG-ATT-labeled MUC1 antibody is stronger than the ICG-sulfo-OSu-labeled MUC1 antibody. Indocyanine Green 96-99 mucin 1, cell surface associated Homo sapiens 112-116 19126960-6 2008 The immunofluorescence studies suggested that the intensity of the infrared fluorescence of the ICG-ATT-labeled MUC1 antibody is stronger than the ICG-sulfo-OSu-labeled MUC1 antibody. Indocyanine Green 147-150 mucin 1, cell surface associated Homo sapiens 112-116 19126960-3 2008 We developed ICG-N-hydroxysulfosuccinimide ester (ICG-sulfo-OSu) and 3-ICG-acyl-1,3-thiazolidine-2-thione (ICG-ATT) as infrared fluorescent-labeling reagents, and anti-human carcinoembryonic antigen (CEA) antibody and MUC1 antibody were labeled with the ICG-derivatives. Indocyanine Green 13-16 mucin 1, cell surface associated Homo sapiens 218-222 19126960-6 2008 The immunofluorescence studies suggested that the intensity of the infrared fluorescence of the ICG-ATT-labeled MUC1 antibody is stronger than the ICG-sulfo-OSu-labeled MUC1 antibody. Indocyanine Green 147-150 mucin 1, cell surface associated Homo sapiens 169-173 17898261-5 2007 The effects of ICG and BBG on phosphorylation of p38 MAPK and cleavage of caspase-9 and caspase-3 were examined by Western blot. Indocyanine Green 15-18 mitogen-activated protein kinase 14 Homo sapiens 49-52 18092113-2 2007 Non-invasive determination of the indocyanine green (ICG) plasma disappearance rate (PDR) offers an opportunity for the early diagnosis of hepato-splanchnic hypoperfusion. Indocyanine Green 34-51 PDR Homo sapiens 85-88 18092113-2 2007 Non-invasive determination of the indocyanine green (ICG) plasma disappearance rate (PDR) offers an opportunity for the early diagnosis of hepato-splanchnic hypoperfusion. Indocyanine Green 53-56 PDR Homo sapiens 85-88 17898261-9 2007 Prominent p38 MAPK phosphorylation was observed in the presence of ICG, even at the low concentration and within a short time exposure; however, no apparent enhancement was observed in the presence of 0.25 mg/mL BBG. Indocyanine Green 67-70 mitogen-activated protein kinase 14 Homo sapiens 10-13 17898261-10 2007 Furthermore, ICG, but not BBG, induced the cleavage of caspase-9 and caspase-3, which was inhibited by an inhibitor of p38 MAPK. Indocyanine Green 13-16 caspase 9 Homo sapiens 55-64 17898261-10 2007 Furthermore, ICG, but not BBG, induced the cleavage of caspase-9 and caspase-3, which was inhibited by an inhibitor of p38 MAPK. Indocyanine Green 13-16 caspase 3 Homo sapiens 69-78 17898261-10 2007 Furthermore, ICG, but not BBG, induced the cleavage of caspase-9 and caspase-3, which was inhibited by an inhibitor of p38 MAPK. Indocyanine Green 13-16 mitogen-activated protein kinase 14 Homo sapiens 119-122 17898261-11 2007 CONCLUSIONS: ICG is toxic to retinal glial cells because it induces apoptosis, involving induction of the caspase cascade through p38 MAPK phosphorylation. Indocyanine Green 13-16 mitogen-activated protein kinase 14 Homo sapiens 130-133 17379633-8 2007 An ammonia tolerance test and an indocyanine green elimination test showed that V1aR-/- mice had lower ammonia clearance due to a decreased intrahepatic circulating blood volume. Indocyanine Green 33-50 arginine vasopressin receptor 1A Mus musculus 80-84 17534116-0 2007 Modulation of Ku70/80, clusterin/ApoJ isoforms and Bax expression in indocyanine-green-mediated photo-oxidative cell damage. Indocyanine Green 69-86 X-ray repair cross complementing 6 Homo sapiens 14-18 17343494-1 2007 We develop a dual-channel optical coherence tomography/indocyanine green (OCT/ICG) fluorescence system based on our previously reported ophthalmic OCT/confocal imaging system. Indocyanine Green 55-72 plexin A2 Homo sapiens 74-77 17343494-1 2007 We develop a dual-channel optical coherence tomography/indocyanine green (OCT/ICG) fluorescence system based on our previously reported ophthalmic OCT/confocal imaging system. Indocyanine Green 55-72 plexin A2 Homo sapiens 147-150 17343494-1 2007 We develop a dual-channel optical coherence tomography/indocyanine green (OCT/ICG) fluorescence system based on our previously reported ophthalmic OCT/confocal imaging system. Indocyanine Green 78-81 plexin A2 Homo sapiens 147-150 17343494-2 2007 The confocal channel is tuned to the fluorescence wavelength range of the ICG dye and light from the same optical source is used to generate the OCT image and to excite the ICG fluorescence. Indocyanine Green 74-77 plexin A2 Homo sapiens 145-148 17534116-0 2007 Modulation of Ku70/80, clusterin/ApoJ isoforms and Bax expression in indocyanine-green-mediated photo-oxidative cell damage. Indocyanine Green 69-86 clusterin Homo sapiens 23-32 17534116-0 2007 Modulation of Ku70/80, clusterin/ApoJ isoforms and Bax expression in indocyanine-green-mediated photo-oxidative cell damage. Indocyanine Green 69-86 clusterin Homo sapiens 33-37 17534116-0 2007 Modulation of Ku70/80, clusterin/ApoJ isoforms and Bax expression in indocyanine-green-mediated photo-oxidative cell damage. Indocyanine Green 69-86 BCL2 associated X, apoptosis regulator Homo sapiens 51-54 16537990-6 2006 ICG-derivative-labeled mouse anti-human carcinoembryonic antigen (CEA) antibody and MUC1 antibody were employed in this study. Indocyanine Green 0-3 CEA cell adhesion molecule 3 Homo sapiens 40-64 25049152-0 2006 Fab fragment labeled with ICG-derivative for detecting digestive tract cancer. Indocyanine Green 26-29 FA complementation group B Homo sapiens 0-3 25049152-7 2006 RESULTS: Both ICG-ATT-labeled Fab and ICG-ATT-labeled IgG were excited by a near infrared ray of 766nm, and maximum emission occurred at 804nm. Indocyanine Green 14-17 FA complementation group B Homo sapiens 30-33 25049152-8 2006 Antibody activities of ICG-ATT-labeled Fab were shown to be similar to those of unlabeled anti-MUC1 antibody. Indocyanine Green 23-26 FA complementation group B Homo sapiens 39-42 25049152-9 2006 The fluorescence intensity obtained from paraffin sections of excised gastric cancer tissues revealed a tendency to be greater with ICG-ATT-labeled Fab than with ICG-ATT-labeled IgG. Indocyanine Green 132-135 FA complementation group B Homo sapiens 148-151 16627864-7 2006 MEASUREMENTS: Hepatocellular metabolism and liver blood flow were measured by plasma disappearance rate of indocyanine green (PDR(ICG)) as a sensitive marker of liver function. Indocyanine Green 107-124 PDR Homo sapiens 126-134 16537990-13 2006 Therefore, we conclude that an anti-CEA (and/or MUC1) antibody with affinity for cancerous lesions and labeled with ICG-derivative can be imaged with this IRFE. Indocyanine Green 116-119 CEA cell adhesion molecule 3 Homo sapiens 36-39 16537990-13 2006 Therefore, we conclude that an anti-CEA (and/or MUC1) antibody with affinity for cancerous lesions and labeled with ICG-derivative can be imaged with this IRFE. Indocyanine Green 116-119 mucin 1, cell surface associated Homo sapiens 48-52 16537990-6 2006 ICG-derivative-labeled mouse anti-human carcinoembryonic antigen (CEA) antibody and MUC1 antibody were employed in this study. Indocyanine Green 0-3 CEA cell adhesion molecule 3 Homo sapiens 66-69 16537990-10 2006 The incubation of freshly resected stomach specimens with ICG-anti-CEA antibody-complex resulted in positive staining of the tumor sites by IRFE, and the IR fluorescent images correlated well with the tumor sites. Indocyanine Green 58-61 CEA cell adhesion molecule 3 Homo sapiens 67-70 16537990-11 2006 The immunohistochemical studies suggested that the intensity of IR fluorescence of ICG-ATT-MUC1 was stronger than that of ICG-sulfo-OSu. Indocyanine Green 83-86 mucin 1, cell surface associated Homo sapiens 91-95 15655445-11 2005 The expression levels of bcl-2 mRNA were higher in cells treated with 0.5% ICG than in those treated with 0.05% ICG and untreated control cells. Indocyanine Green 75-78 BCL2, apoptosis regulator Rattus norvegicus 25-30 16787331-0 2005 ICG-001, a novel small molecule regulator of TCF/beta-catenin transcription. Indocyanine Green 0-3 hepatocyte nuclear factor 4 alpha Homo sapiens 45-48 16787331-0 2005 ICG-001, a novel small molecule regulator of TCF/beta-catenin transcription. Indocyanine Green 0-3 catenin beta 1 Homo sapiens 49-61 15782138-6 2005 ICG-001-mediated downregulation of survivin expression enhanced caspase-3 activity and apoptosis, which was rescued by overexpression of wild type but not mutant (C84A) survivin. Indocyanine Green 0-3 caspase 3 Homo sapiens 64-73 16140478-13 2006 Furthermore, ICG protected mice against carbon tetrachloride (CCl4) hepatotoxicity. Indocyanine Green 13-16 chemokine (C-C motif) ligand 4 Mus musculus 62-66 16140478-14 2006 Since CCl4 undergoes minimal biliary excretion and does not compete for biliary transport function, this finding supports the notion that cholestasis itself rather than competition for canalicular transporters is central to the hepatoprotection by ICG and other cholephilic dyes. Indocyanine Green 248-251 chemokine (C-C motif) ligand 4 Mus musculus 6-10 16633758-0 2006 99mTc-DTPA-galactosyl-human-serum-albumin liver scintigraphy for evaluating hepatic functional reserve before hepatectomy in a patient with indocyanine green excretory defect: report of a case. Indocyanine Green 140-157 GNAS complex locus Homo sapiens 0-41 16633758-6 2006 Thus, we consider that GSA liver scintigraphy is the best diagnostic modality for evaluating hepatic functional reserve in a patient with ICG excretory defect. Indocyanine Green 138-141 GNAS complex locus Homo sapiens 23-26 16179040-5 2005 Preoperative median [range] cardiac output was 3.85 [2.2-6.0] l.min(-1) for bolus thermodilution cardiac output and 4.2 [2.0-7.2] l.min(-1) for pulse dye densitometry using indocyanine green 20 mg. Indocyanine Green 173-190 CD59 molecule (CD59 blood group) Homo sapiens 64-70 16179040-5 2005 Preoperative median [range] cardiac output was 3.85 [2.2-6.0] l.min(-1) for bolus thermodilution cardiac output and 4.2 [2.0-7.2] l.min(-1) for pulse dye densitometry using indocyanine green 20 mg. Indocyanine Green 173-190 CD59 molecule (CD59 blood group) Homo sapiens 132-138 15900017-9 2005 The uptake of ketoprofen by hepatocytes was significantly inhibited by probenecid and rOat2 inhibitors (indocyanine green, indomethacin, glibenclamide, and salicylate). Indocyanine Green 104-121 solute carrier family 22 member 7 Rattus norvegicus 86-91 15648637-1 2005 We have developed a dual-channel optical coherence tomography-Indocyanine Green dye (OCT-ICG) fluorescence system based on a previously reported ophthalmic OCT confocal imaging system. Indocyanine Green 62-79 plexin A2 Homo sapiens 85-88 15648637-1 2005 We have developed a dual-channel optical coherence tomography-Indocyanine Green dye (OCT-ICG) fluorescence system based on a previously reported ophthalmic OCT confocal imaging system. Indocyanine Green 62-79 plexin A2 Homo sapiens 156-159 15655445-11 2005 The expression levels of bcl-2 mRNA were higher in cells treated with 0.5% ICG than in those treated with 0.05% ICG and untreated control cells. Indocyanine Green 112-115 BCL2, apoptosis regulator Rattus norvegicus 25-30 15619338-6 2004 With cholestatic serum added into the HGF-induced system, differentiated cells grew into similar angular cells, and had a higher level synthesis of glycogen, triglycerides, albumin and urea nitrogen with positive ICG and FDA staining. Indocyanine Green 213-216 hepatocyte growth factor Mus musculus 38-41 15248975-4 2004 This electrode was coated with a monolayer of human serum albumin (HSA) protein that had been labeled with a fluorescent dye, indocyanine green (ICG). Indocyanine Green 126-143 albumin Homo sapiens 52-71 15314234-3 2004 We identified ICG-001, a small molecule that down-regulates beta-catenin/T cell factor signaling by specifically binding to cyclic AMP response element-binding protein. Indocyanine Green 14-17 catenin (cadherin associated protein), beta 1 Mus musculus 60-72 15561205-7 2004 A significant correlation was obtained between the GSA-Rmax and the 15-minute retention rate of indocyanine green. Indocyanine Green 96-113 GNAS complex locus Homo sapiens 51-59 15561211-6 2004 The preoperative GSA-LV values were significantly correlated with the hepatocyte volume and the 15-minute retention rate of indocyanine green (ICGR15). Indocyanine Green 124-141 GNAS complex locus Homo sapiens 17-20 15552961-5 2004 Multivariate regression analysis showed that indocyanine green retention at 15 min serum albumin level, and local recurrence were significant independent predictors of survival, and that serum albumin and alanine aminotransferase levels were significant independent predictors of recurrence. Indocyanine Green 45-62 albumin Homo sapiens 89-96 15248975-4 2004 This electrode was coated with a monolayer of human serum albumin (HSA) protein that had been labeled with a fluorescent dye, indocyanine green (ICG). Indocyanine Green 145-148 albumin Homo sapiens 52-71 14690419-2 2003 Alanine mutagenesis was used to probe all the side chain mediated interactions that occur between tRNA(Arg2)(ICG) and ArgRS. Indocyanine Green 109-112 acetyl-CoA:L-glutamate N-acetyltransferase Saccharomyces cerevisiae S288C 98-107 15298422-5 2004 RESULTS: The mean baseline percentage disappearence rate (PDR) of indocyanine green (ICG) was 19.84 +/- 4.47%/min. Indocyanine Green 66-83 PDR Homo sapiens 58-61 15298422-5 2004 RESULTS: The mean baseline percentage disappearence rate (PDR) of indocyanine green (ICG) was 19.84 +/- 4.47%/min. Indocyanine Green 85-88 PDR Homo sapiens 58-61 12747626-3 2003 SUBJECTS AND METHODS: ICG-sulfo-OSu-labeled MUC1 antibody and an IR fluorescence imaging system were employed in the present study. Indocyanine Green 22-25 mucin 1, cell surface associated Homo sapiens 44-48 14992087-1 2003 OBJECTIVES: To evaluate the effect of dopexamine and iloprost on the plasma disappearance rate (PDR) of indocyanine green (ICG) in patients in septic shock in a prospective clinical trial. Indocyanine Green 104-121 PDR Homo sapiens 96-99 14992087-1 2003 OBJECTIVES: To evaluate the effect of dopexamine and iloprost on the plasma disappearance rate (PDR) of indocyanine green (ICG) in patients in septic shock in a prospective clinical trial. Indocyanine Green 123-126 PDR Homo sapiens 96-99 12837539-6 2003 ICG-ATT-labeled anti-MUC1 antibody produced stronger staining than that by ICG-sulfo-OSu-labeled antibody. Indocyanine Green 0-3 mucin 1, cell surface associated Homo sapiens 21-25 12747626-7 2003 RESULTS: The incubation of paraffin sections with ICG-sulfo-OSu-labeled MUC1 antibody resulted in positive staining of the tumor sites by an IR fluorescence imaging system, and the intensity of fluorescence was increased depending on the concentration of octylglucoside and grade of imaging processing. Indocyanine Green 50-53 mucin 1, cell surface associated Homo sapiens 72-76 11519943-4 2001 To this end, pseudofluorogenic ICG was used both as an on-column label for human serum albumin (HSA) and as a precolumn label for a model mixture of proteins, including ribonuclease A, transferrin, and cytochrome c. Indocyanine Green 31-34 albumin Homo sapiens 81-100 15174600-0 2003 Nirs mediated CBF assessment: validating the indocyanine green bolus transit detection by comparison with coloured microsphere flowmetry. Indocyanine Green 45-62 CCAAT enhancer binding protein zeta Homo sapiens 14-17 11935282-6 2002 ICG staining developed gradually at the level of the RPE or Bruch"s membrane near sites of previous staining. Indocyanine Green 0-3 ribulose-phosphate 3-epimerase Oryctolagus cuniculus 53-56 11983009-8 2002 The serum apolipoprotein A-1 levels showed significant correlations with the serum high-density lipoprotein cholesterol, lectin-cholesterol acyltransferase and prealbumin levels on postoperative days 7 and 14; however, there was no significant correlation with the indocyanine green retention test. Indocyanine Green 265-282 apolipoprotein A1 Homo sapiens 10-28 11571680-3 2001 MATERIALS AND METHODS: ICG-sulfo-OSu-labeled mouse anti-human carcinoembryonic antigen (CEA) antibody and an infrared fluorescence endoscope were used in this study. Indocyanine Green 23-26 CEA cell adhesion molecule 3 Homo sapiens 62-86 11571680-3 2001 MATERIALS AND METHODS: ICG-sulfo-OSu-labeled mouse anti-human carcinoembryonic antigen (CEA) antibody and an infrared fluorescence endoscope were used in this study. Indocyanine Green 23-26 CEA cell adhesion molecule 3 Homo sapiens 88-91 11571680-6 2001 RESULTS: Treatment of freshly resected stomach specimens with ICG-sulfo-OSu-labeled-anti-CEA antibody complex resulted in positive staining of the tumor sites on infrared fluorescence endoscopy, and the infrared fluorescent images correlated well with the tumor sites. Indocyanine Green 62-65 CEA cell adhesion molecule 3 Homo sapiens 89-92 11504818-4 2001 Ketoprofen, indocyanine green and glibenclamide are potent inhibitors of the uptake of [(14)C]salicylate via rOat2 (K(i) of approximately 12 microM), while diclofenac, benzoate, verapamil, ibuprofen, and tolbutamide are moderate inhibitors (K(i) of approximately 150 microM). Indocyanine Green 12-29 solute carrier family 22 (organic anion transporter), member 7, pseudogene 1 Rattus norvegicus 109-114 12506098-8 2003 Of the early-response genes, the expression of c-fos was specifically enhanced by light, with additive effects from the presence of ICG. Indocyanine Green 132-135 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 47-52 11993509-7 2002 Good images of cancer cells could be obtained by infrared fluorescence observation using the ICG-sulfo-OSu-labeled anti-MUC1 antibody. Indocyanine Green 93-96 mucin 1, cell surface associated Homo sapiens 120-124 11993509-9 2002 The ICG-sulfo-OSu-labeled anti-MUC1 antibody has possible usefulness for the screening of cancer via infrared fluorescence endoscopy. Indocyanine Green 4-7 mucin 1, cell surface associated Homo sapiens 31-35 11519943-4 2001 To this end, pseudofluorogenic ICG was used both as an on-column label for human serum albumin (HSA) and as a precolumn label for a model mixture of proteins, including ribonuclease A, transferrin, and cytochrome c. Indocyanine Green 31-34 transferrin Homo sapiens 185-196 11519943-4 2001 To this end, pseudofluorogenic ICG was used both as an on-column label for human serum albumin (HSA) and as a precolumn label for a model mixture of proteins, including ribonuclease A, transferrin, and cytochrome c. Indocyanine Green 31-34 cytochrome c, somatic Homo sapiens 202-214 11126272-1 2000 OBJECTIVES: To evaluate the effect of the stable prostacyclin analogue iloprost on the plasma disappearance rate of indocyanine green (PDR) in patients with septic shock. Indocyanine Green 116-133 PDR Homo sapiens 135-138 11302927-0 2001 Multidrug resistance p-glycoprotein 2 is essential for the biliary excretion of indocyanine green. Indocyanine Green 80-97 ATP-binding cassette, sub-family B (MDR/TAP), member 4 Mus musculus 0-37 11232703-7 2001 RESULTS: The preoperative GSA-LV values were significantly correlated with the hepatocyte volume and the 15-min retention rate of indocyanine green (ICGR15). Indocyanine Green 130-147 GNAS complex locus Homo sapiens 26-29 11134001-7 2001 The organic anion indocyanine green potently inhibited transport mediated by OATP2, with a K(i) value of 112 nm, but did not inhibit transport mediated by OATP8. Indocyanine Green 18-35 solute carrier organic anion transporter family member 1B1 Homo sapiens 77-82 11153617-3 2000 In septic shock patients, NAC improved the clearance of indocyanine green and the relationship of systemic oxygen consumption to oxygen demand. Indocyanine Green 56-73 synuclein alpha Homo sapiens 26-29 10994775-2 2000 The cellular uptake of ICG (1-50 microM, incubation times 1, 4, 24 h) was saturable, highly cumulative and could be inhibited by the addition of 250 microM bromosulphophthalein indicating the involvement of the organic anion transporting polypeptide (OATP). Indocyanine Green 23-26 solute carrier organic anion transporter family member 1A2 Homo sapiens 211-249 11787473-7 2000 Serum TPO levels were positively correlated with prothrombin time and serum albumin (P < 0.05, in each case), and negatively correlated with Indocyanine Green test and Pugh score (P < 0.01 and P < 0.05 respectively). Indocyanine Green 144-161 thrombopoietin Homo sapiens 6-9 10994775-4 2000 Fluorescence microscopy revealed a cytoplasmic distribution of ICG, probably bound to glutathione S-transferase. Indocyanine Green 63-66 glutathione S-transferase kappa 1 Homo sapiens 86-111 10994775-2 2000 The cellular uptake of ICG (1-50 microM, incubation times 1, 4, 24 h) was saturable, highly cumulative and could be inhibited by the addition of 250 microM bromosulphophthalein indicating the involvement of the organic anion transporting polypeptide (OATP). Indocyanine Green 23-26 solute carrier organic anion transporter family member 1A2 Homo sapiens 251-255 10764859-7 2000 Indocyanine green angiography revealed defined patterns of fluorescence in 27 cases (90%): 12 hot spots, seven plaques, and eight combined hot spots and plaques. Indocyanine Green 0-17 alcohol dehydrogenase iron containing 1 Homo sapiens 94-97 10522859-11 1999 By Cox regression analysis, the preoperative indocyanine green retention value at 15 minutes after injection (RR, 1.03; 95% CI, 1.01-1.06), blood transfusion (RR, 1.191; 95% CI, 1.078-1.316), tumor rupture (RR, 1.48; 95% CI, 1.08-2.04), and TNM stage (RR, 1.62; 95% CI, 1.27-2.07) were shown to be significant independent factors that influenced cumulative survival rate. Indocyanine Green 45-62 teneurin transmembrane protein 1 Homo sapiens 241-244 11213474-5 2000 The TRX levels were significantly correlated with serum lipid peroxide levels and indocyanine green exclusion test values, and were markedly decreased following treatment with Stronger Neo-Minophagen C or ursodeoxycholic acid. Indocyanine Green 82-99 thioredoxin Homo sapiens 4-7 10389705-4 1999 Moreover, in a subgroup of 54 patients we analyzed the relationships among the AST/ALT ratio and indocyanine green clearance and half-life. Indocyanine Green 97-114 solute carrier family 17 member 5 Homo sapiens 79-82 10423330-4 1999 RESULTS: The preoperative factors with which the portal ET-1 showed a positive correlation were the indocyanine green retention rate at 15 min (ICG R15) and portal venous pressure. Indocyanine Green 100-117 endothelin 1 Homo sapiens 56-60 10409155-14 1999 In livers from parallel-treated nonperfused rats, mRNA for the organic anion transporting protein-1 (Oatp1, which is likely to mediate ICG uptake) was unaffected by LPS, whereas the concentration of Oatp1 protein was reduced. Indocyanine Green 135-138 solute carrier organic anion transporter family, member 1a1 Rattus norvegicus 63-99 10409155-14 1999 In livers from parallel-treated nonperfused rats, mRNA for the organic anion transporting protein-1 (Oatp1, which is likely to mediate ICG uptake) was unaffected by LPS, whereas the concentration of Oatp1 protein was reduced. Indocyanine Green 135-138 solute carrier organic anion transporter family, member 1a1 Rattus norvegicus 101-106 10453940-5 1999 RESULTS: Preoperative plasma IGF-1 level showed a negative correlation with indocyanine green retention rate. Indocyanine Green 76-93 insulin like growth factor 1 Homo sapiens 29-34 10435358-5 1999 RESULTS: Positive staining was seen as a brownish discoloration of oxidized 3,3"-diaminobenzidine tetrahydrochloride (DAB) in sections that reacted with ICG-sulfo-OSu-labeled anti-CEA antibody, and the fluorescence was well-matched with the oxidized DAB-positive sites. Indocyanine Green 153-156 CEA cell adhesion molecule 3 Homo sapiens 180-183 10389705-7 1999 The AST/ALT ratio showed significant correlations both with MEGX formation and with indocyanine green clearance and half-life. Indocyanine Green 84-101 solute carrier family 17 member 5 Homo sapiens 4-7 10410927-4 1999 This paper investigates the suitability of ICG as a fluorescent label for the separation and detection of human serum albumin (HSA) by CE with diode-LIF detection. Indocyanine Green 43-46 LIF interleukin 6 family cytokine Homo sapiens 149-152 10430357-12 1999 The pre-operative HGF level was affected by patient age (p=0.0236), and the post-operative peak HGF level was positively correlated with the pre-operative indocyanin green retention rate (ICGR15) and GOT level (p=0.0320 and 0.0234 respectively). Indocyanine Green 155-171 hepatocyte growth factor Homo sapiens 96-99 10218712-1 1999 PURPOSE: To describe the plasma level of plasminogen activator inhibitor 1, the major antifibrinolytic agent, in eyes with central serous chorioretinopathy, in which choroidal thrombosis is suspected as the underlying condition based on the findings of choroidal hyperpermeability in indocyanine green angiograms. Indocyanine Green 284-301 serpin family E member 1 Homo sapiens 41-74 10218712-4 1999 CONCLUSION: Increased plasminogen activator inhibitor 1 concentrations in patients with central serous chorioretinopathy support the hypothesis that the choroidal hyperpermeability disclosed by indocyanine green angiography is caused from impaired fibrinolysis and the resulting thrombotic occlusion in the choroidal veins. Indocyanine Green 194-211 serpin family E member 1 Homo sapiens 22-55 9927161-9 1999 Indocyanine green clearance was also significantly correlated with alanine aminotransferase and prothrombin time at 24 h post-transplantation (r=-0.35, p<0.02 and r=-0.4, p<0.0077, respectively). Indocyanine Green 0-17 coagulation factor II, thrombin Homo sapiens 96-107 10083762-12 1999 Preoperatively, HGF and CRP concentrations were positively affected by larger tumor size, and IL-6 concentration was negatively affected by hepatitis B surface antigen positivity and a higher indocyanine green (ICG) retention rate. Indocyanine Green 192-209 interleukin 6 Homo sapiens 94-98 10083762-12 1999 Preoperatively, HGF and CRP concentrations were positively affected by larger tumor size, and IL-6 concentration was negatively affected by hepatitis B surface antigen positivity and a higher indocyanine green (ICG) retention rate. Indocyanine Green 211-214 interleukin 6 Homo sapiens 94-98 9619785-8 1998 CONCLUSIONS: The anionic dye ICG is able to interfere with the hepatic handling of a cationic, amidinophenylalanine piperazide-type thrombin inhibitor with the consequence of reduced hepatic clearance leading to higher plasma levels and lower biliary excretion of the latter. Indocyanine Green 29-32 coagulation factor II Rattus norvegicus 132-140 9583693-14 1998 The preoperative level of soluble ICAM-1 correlated with that ofVCAM- 1, PMN elastase, albumin, aspartate aminotransferease (AST), and the indocyanine green dye retention test at 15 minutes (ICG R15), while the preoperative level of VCAM-1 correlated with albumin, the hepaplastin test, AST, and ICG R15. Indocyanine Green 139-156 intercellular adhesion molecule 1 Homo sapiens 34-40 9619785-0 1998 Influence of indocyanine green on plasma disappearance and biliary excretion of a synthetic thrombin inhibitor of the 3-amidinophenyl-alanine piperazide-type in rats. Indocyanine Green 13-30 coagulation factor II Rattus norvegicus 92-100 9878669-4 1998 The usefulness of indocyanine green angiography to aid in the diagnosis and treatment of a variety of chorioretinal diseases was reported during the last years. Indocyanine Green 18-35 activation induced cytidine deaminase Homo sapiens 51-54 9465840-8 1998 RESULTS: Indocyanine green clearance and clearance of both t-PA antigen (r = 0.78; p < 0:01) and t-PA activity (r = 0.54; p < 0.05) were significantly related. Indocyanine Green 9-26 plasminogen activator, tissue type Homo sapiens 100-104