PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26446447-9	2016	In vitro, 30-min preincubation with 100 muM clopidogrel acyl-beta-D-glucuronide inhibited the depletion rate of 0.5 muM paclitaxel by 51% and the formation rate of 6-hydroxypaclitaxel by 77%.	6-hydroxytaxol	164-183	latexin	Homo sapiens	40-43
26551762-5	2016	Although the degree of inhibition was small, losartan significantly inhibited the production of 6alpha-hydroxypaclitaxel at a concentration of 1 mumol/L in only HL20 with the CYP2C8*3/*3 genotype.	6-hydroxytaxol	96-120	dynein axonemal heavy chain 9	Homo sapiens	161-165
26551762-5	2016	Although the degree of inhibition was small, losartan significantly inhibited the production of 6alpha-hydroxypaclitaxel at a concentration of 1 mumol/L in only HL20 with the CYP2C8*3/*3 genotype.	6-hydroxytaxol	96-120	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	175-181
21056987-9	2011	Clearance of 6alpha-hydroxypaclitaxel (fraction metabolized) was significantly correlated (p < 0.05) to the ABCB1 allele G2677T/A.	6-hydroxytaxol	13-37	ATP binding cassette subfamily B member 1	Homo sapiens	111-116
21056987-11	2011	The correlation of G2677T/A with 6alpha-hydroxypaclitaxel has not been described previously but supports other findings of the ABCB1 transporter playing a part in paclitaxel metabolism.	6-hydroxytaxol	33-57	ATP binding cassette subfamily B member 1	Homo sapiens	127-132
15655291-5	2005	Production of 6alpha-hydroxypaclitaxel, a metabolite of CYP2C8, was 2.3-fold larger than 3"-p-hydroxypaclitaxel, a metabolite of CYP3A4.	6-hydroxytaxol	14-38	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	56-62
12920504-6	2003	In human liver microsomes, 6alpha-hydroxypaclitaxel (6alpha-OHP), formed by CYP2C8, was the main metabolite, while C3"-OHP, C2-OHP and another product different from di-OHP were minor metabolites, formed by CYP3A4.	6-hydroxytaxol	27-51	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	76-82
10064574-7	1999	For CYP2C8-catalyzed 6alpha-hydroxy-paclitaxel formation the IC50 was 20 microM and for CYP1A2, CYP2C19, and CYP3A catalyzed reactions, no IC50 could be determined up to 100 microM fluvastatin.	6-hydroxytaxol	21-46	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	4-10
34393439-3	2021	Hence, we report the binding features of 10-Deacetyltaxol, 7-Epi-10-deacetyltaxol, 7-Epi-Taxol and 6alpha-Hydroxypaclitaxel with mTOR for further consideration.	6-hydroxytaxol	99-123	mechanistic target of rapamycin kinase	Homo sapiens	129-133
11895918-7	2002	Our results enabled us to predict and subsequently affirm that the major human hepatic metabolite, 6alpha-hydroxypaclitaxel, would induce cyclooxygenase-2 in human cells but not in murine cells.	6-hydroxytaxol	99-123	prostaglandin-endoperoxide synthase 2	Homo sapiens	138-154
11410497-0	2001	The P-glycoprotein antagonist PSC 833 increases the plasma concentrations of 6alpha-hydroxypaclitaxel, a major metabolite of paclitaxel.	6-hydroxytaxol	77-101	ATP binding cassette subfamily B member 1	Homo sapiens	4-18
9842986-4	1998	The formation of 6alpha-hydroxypaclitaxel and 3"-p-hydroxypaclitaxel is catalyzed by cytochrome P450 isozymes CYP2C8 and CYP3A4, respectively.	6-hydroxytaxol	17-41	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	110-116
9842986-4	1998	The formation of 6alpha-hydroxypaclitaxel and 3"-p-hydroxypaclitaxel is catalyzed by cytochrome P450 isozymes CYP2C8 and CYP3A4, respectively.	6-hydroxytaxol	17-41	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	121-127
9842986-10	1998	Significant inhibition of paclitaxel conversion to 6alpha-hydroxypaclitaxel and 3"-p-hydroxypaclitaxel was observed in the presence of R-verapamil, tamoxifen and VP-16 (P 0.005).	6-hydroxytaxol	51-75	host cell factor C1	Homo sapiens	162-167
7473140-3	1995	Four metabolites of paclitaxel (6 alpha-hydroxypaclitaxel, metabolites B, C and A) were formed in vitro, via CYP2C8, 3A4, 3A4 and both 2C8 and 3A4, respectively.	6-hydroxytaxol	32-57	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	109-115
7923194-0	1994	Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8.	6-hydroxytaxol	40-60	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	70-89
34304352-3	2022	Paclitaxel is predominantly metabolized in the liver by cytochrome P450 (CYP) 2C8 to produce 6alpha-hydroxypaclitaxel and by CYP3A4 to produce 3"-p-hydroxypaclitaxel.	6-hydroxytaxol	93-117	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	56-81