PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34158867-6 2021 The therapeutic potential of a combinatorial miR-375-decoy/simvastatin treatment was validated by live cell imaging. Simvastatin 59-70 microRNA 375 Homo sapiens 45-52 25510525-1 2015 Vitamin D is associated with skeletal muscle physiology and function and may play a role in intramuscular inflammation, possibly via the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 137-155 25510525-1 2015 Vitamin D is associated with skeletal muscle physiology and function and may play a role in intramuscular inflammation, possibly via the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 157-160 31582399-9 2019 CONCLUSION: Vitamin D enhances IFN-beta induction of multiple proteins and also reverses the Th1/Th2 bias in MS seen with IFN-beta alone. Vitamin D 12-21 negative elongation factor complex member C/D Homo sapiens 93-96 31274211-9 2019 Vitamin D seems to inhibit Th1 immune responses and have no effect on Th2 responses. Vitamin D 0-9 negative elongation factor complex member C/D Homo sapiens 27-30 25536521-1 2015 The 1,25-dihydroxyvitamin D3 (1,25D) hormone is derived from vitamin D generated in skin or obtained from the diet, and binds to and activates the vitamin D receptor (VDR) in target tissues including kidney, colon/small intestine, and bone/muscle. Vitamin D 18-27 vitamin D receptor Homo sapiens 147-165 25536521-1 2015 The 1,25-dihydroxyvitamin D3 (1,25D) hormone is derived from vitamin D generated in skin or obtained from the diet, and binds to and activates the vitamin D receptor (VDR) in target tissues including kidney, colon/small intestine, and bone/muscle. Vitamin D 18-27 vitamin D receptor Homo sapiens 167-170 30887870-4 2019 Our aim was to identify the association of specific single nucleotide variants in the PTPN22, VDR, KL, and CYP27B1 genes and vitamin D-metabolism, heart malformation, renal malformation, thyroiditis, and low-BMD in 61 Mexican TS-patients. Vitamin D 125-134 protein tyrosine phosphatase non-receptor type 22 Homo sapiens 86-92 25377645-2 2015 As the specific receptor of vitamin D, VDR plays an important role in regulating immune system by combining with vitamin D. Vitamin D 28-37 vitamin D receptor Homo sapiens 39-42 25377645-2 2015 As the specific receptor of vitamin D, VDR plays an important role in regulating immune system by combining with vitamin D. Vitamin D 113-122 vitamin D receptor Homo sapiens 39-42 25234352-11 2015 The higher circulating VDBP concentrations and higher vitamin D catabolic rate among Caucasian Americans observed here appear to be consistent with lower bone mineral density and racial and ethnic differences in vitamin D-inducing cytokines. Vitamin D 212-221 GC vitamin D binding protein Homo sapiens 23-27 30887870-4 2019 Our aim was to identify the association of specific single nucleotide variants in the PTPN22, VDR, KL, and CYP27B1 genes and vitamin D-metabolism, heart malformation, renal malformation, thyroiditis, and low-BMD in 61 Mexican TS-patients. Vitamin D 125-134 vitamin D receptor Homo sapiens 94-97 30887870-8 2019 In addition, we identified gene-gene interactions between variants in genes KL, CYP27B1 and VDR related to vitamin D-metabolism and low-BMD in TS-patients. Vitamin D 107-116 vitamin D receptor Homo sapiens 92-95 31591986-1 2019 BACKGROUND: The proposed role of Vitamin D Receptor (VDR) in various cancers underscores the importance of vitamin D compounds as a novel therapeutic agent in the prevention of occurrence and progression of cancer. Vitamin D 107-116 vitamin D receptor Homo sapiens 33-51 26045671-0 2015 Association of the CYP24A1-rs2296241 polymorphism of the vitamin D catabolism enzyme with hormone-related cancer risk: a meta-analysis. Vitamin D 57-66 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 19-26 31591986-1 2019 BACKGROUND: The proposed role of Vitamin D Receptor (VDR) in various cancers underscores the importance of vitamin D compounds as a novel therapeutic agent in the prevention of occurrence and progression of cancer. Vitamin D 107-116 vitamin D receptor Homo sapiens 53-56 31446716-4 2019 There are certain specific associations between vitamin D and IL-33/ST2 in the pathogenesis of AR. Vitamin D 48-57 ST2 Homo sapiens 68-71 26029210-0 2015 Selective Hyaluronan-CD44 Signaling Promotes miRNA-21 Expression and Interacts with Vitamin D Function during Cutaneous Squamous Cell Carcinomas Progression Following UV Irradiation. Vitamin D 84-93 CD44 molecule (Indian blood group) Homo sapiens 21-25 25873367-1 2015 One variable that may affect the ability of vitamin D to reduce colon cancer risk is the expression of its high-affinity receptor, VDR. Vitamin D 44-53 vitamin D receptor Homo sapiens 131-134 31599133-9 2019 Conventional therapy for XLH and other disorders of FGF23-mediated hypophosphatemia involves multiple daily doses of oral phosphate salts and active vitamin D analogs, such as calcitriol or alfacalcidol. Vitamin D 149-158 fibroblast growth factor 23 Homo sapiens 52-57 25873367-11 2015 Determining the mechanisms of VDR regulation in colon neoplasms may significantly enhance our ability to use vitamin D as a cancer prevention agent. Vitamin D 109-118 vitamin D receptor Homo sapiens 30-33 25616026-7 2015 Increased maternal dietary vitamin D was associated with significant increases in IL-10 release by AEC after stimulation with TNF-alpha/IL-1beta (P = 0.024) or HDM (P = 0.049). Vitamin D 27-36 interleukin 10 Homo sapiens 82-87 31891001-2 2019 CYP24A1-mediated vitamin D clearance, calculated as the ratio of serum 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 (the vitamin D metabolic ratio, VDMR), is induced by 1,25-dihydroxyvitamin D and may assess tissue-level activity. Vitamin D 17-26 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 0-7 31891001-2 2019 CYP24A1-mediated vitamin D clearance, calculated as the ratio of serum 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 (the vitamin D metabolic ratio, VDMR), is induced by 1,25-dihydroxyvitamin D and may assess tissue-level activity. Vitamin D 86-95 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 0-7 31891001-11 2019 Conclusion: Lower VDMR, a measure of CYP24A1-mediated vitamin D clearance, was significantly associated with all-cause mortality but not with progression to ESRD in patients with CKD. Vitamin D 54-63 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 37-44 31555149-3 2019 Active vitamin D mediates its function via the vitamin D receptor (Vdr), which is a ligand-activated transcription factor. Vitamin D 7-16 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 47-65 31555149-3 2019 Active vitamin D mediates its function via the vitamin D receptor (Vdr), which is a ligand-activated transcription factor. Vitamin D 7-16 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 67-70 31461904-3 2019 FGF23 is a bone-derived hormone that is essential for regulating vitamin D and phosphate homeostasis. Vitamin D 65-74 fibroblast growth factor 23 Homo sapiens 0-5 31534663-8 2019 Vitamin D was also inversely related to TSH, HOMA-IR, and levels of anti-TG and anti-TPO. Vitamin D 0-9 thyroid peroxidase Homo sapiens 85-88 31534963-0 2019 Relationship between Serum Vitamin D and Calcium Levels and Vitamin D Receptor Gene Polymorphisms in Colorectal Cancer. Vitamin D 27-36 vitamin D receptor Homo sapiens 60-78 31534963-2 2019 The biological action of vitamin D and its metabolites is mediated by the transcription factor vitamin D receptor (VDR). Vitamin D 25-34 vitamin D receptor Homo sapiens 95-113 31534963-2 2019 The biological action of vitamin D and its metabolites is mediated by the transcription factor vitamin D receptor (VDR). Vitamin D 25-34 vitamin D receptor Homo sapiens 115-118 31534963-4 2019 The aim of the current study was to assess the relationship between serum vitamin D metabolite and calcium levels with VDR polymorphisms in normal and colorectal cancer (CRC) patients. Vitamin D 74-83 vitamin D receptor Homo sapiens 119-122 31534963-7 2019 Results: The homozygous genotype (aa) of the ApaI VDR polymorphism (rs7975232) was found to correlate with total serum vitamin D levels of CRC patients, while the heterozygous (Tt) TaqI VDR polymorphism (rs731236) was associated with serum calcium levels. Vitamin D 119-128 vitamin D receptor Homo sapiens 50-53 31434255-6 2019 We also identified additional associations with 25(OH)D, as well as CRC risk, and several potentially novel SNPs in genes related to vitamin D transport and action (LRP2, CUBN, NCOA7, and HDAC9). Vitamin D 133-142 cubilin Homo sapiens 171-175 31434255-6 2019 We also identified additional associations with 25(OH)D, as well as CRC risk, and several potentially novel SNPs in genes related to vitamin D transport and action (LRP2, CUBN, NCOA7, and HDAC9). Vitamin D 133-142 nuclear receptor coactivator 7 Homo sapiens 177-182 31434255-6 2019 We also identified additional associations with 25(OH)D, as well as CRC risk, and several potentially novel SNPs in genes related to vitamin D transport and action (LRP2, CUBN, NCOA7, and HDAC9). Vitamin D 133-142 histone deacetylase 9 Homo sapiens 188-193 31406210-4 2019 Stimulation of myeloid blasts" maturation by all-trans retinoic acid (ATRA) or 1alpha,25-dihydroxyvitamin D3 (vitamin D) increased the CD11b+ fraction that expressed PD-1 ligands in response to IFN-gamma. Vitamin D 98-107 integrin subunit alpha M Homo sapiens 135-140 31395070-10 2019 CONCLUSIONS: Findings of this study showed that genetic variation in the VDR gene was associated with changes in cardio-metabolic parameters in breast cancer survivors, supplemented with vitamin D3, results could provide a novel insight into better understanding of which subset of individuals benefit most from normalization of vitamin D status. Vitamin D 187-196 vitamin D receptor Homo sapiens 73-76 31431821-6 2019 Highly expressed miR-155 has been downregulated by flavonoids (through a quercetin-rich diet) and by vitamin D. Vitamin D 101-110 microRNA 155 Homo sapiens 17-24 30321335-2 2019 Vitamin D is the precursor of 25-hydroxyvitamin D and other metabolites, including 1,25(OH)2D, the ligand for the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 114-132 30321335-2 2019 Vitamin D is the precursor of 25-hydroxyvitamin D and other metabolites, including 1,25(OH)2D, the ligand for the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 134-137 31125456-4 2019 Further, we demonstrate that the expression of CAII and CAIX in these cells is significantly up-regulated by the biologically active metabolites of vitamin A (all-trans retinoic acid) and vitamin D (1alpha,25-dihydroxyvitamin D3 ), respectively. Vitamin D 188-197 carbonic anhydrase 2 Homo sapiens 47-51 31477207-3 2019 Vitamin D deficiency reduced the expression of the glucocorticoid-inactivating enzyme Hsd11b2 in the female placenta, but did not alter maternal glucocorticoid levels, feto-placental weights, or placental expression of other glucocorticoid-related genes at mid-gestation. Vitamin D 0-9 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 86-93 25813397-8 2015 We found that the vitamin D-treated mice had lower expression levels of caspase-3 than the vehicle-treated mice. Vitamin D 18-27 caspase 3 Mus musculus 72-81 25957423-0 2015 Role of vitamin D in improvement in changes of podocyte P-cadherin/beta-catenin complex induced by diabetic conditions. Vitamin D 8-17 catenin (cadherin associated protein), beta 1 Mus musculus 67-79 25957423-1 2015 INTRODUCTION: This study aimed to investigate the effect of vitamin D on the pathologic changes of podocyte beta-catenin and P-cadherin and podocyte permeability induced by diabetic conditions. Vitamin D 60-69 catenin (cadherin associated protein), beta 1 Mus musculus 108-120 24996526-1 2015 Fibroblast growth factor 23 (FGF23), a central regulator of phosphate and vitamin D metabolism, is mainly produced by osteocytes in bone and exerts its effects on distant organs. Vitamin D 74-83 fibroblast growth factor 23 Mus musculus 0-27 24996526-1 2015 Fibroblast growth factor 23 (FGF23), a central regulator of phosphate and vitamin D metabolism, is mainly produced by osteocytes in bone and exerts its effects on distant organs. Vitamin D 74-83 fibroblast growth factor 23 Mus musculus 29-34 25447737-1 2015 The active form of vitamin D (1alpha,25-dihydroxyvitamin D, 1,25(OH)2D) exerts its genomic effects via binding to a nuclear high-affinity vitamin D receptor (VDR). Vitamin D 19-28 vitamin D receptor Homo sapiens 138-156 25447737-1 2015 The active form of vitamin D (1alpha,25-dihydroxyvitamin D, 1,25(OH)2D) exerts its genomic effects via binding to a nuclear high-affinity vitamin D receptor (VDR). Vitamin D 19-28 vitamin D receptor Homo sapiens 158-161 25447737-2 2015 Recent deep sequencing analysis of VDR binding locations across the complete genome has significantly expanded our understanding of the actions of vitamin D and VDR on gene transcription. Vitamin D 147-156 vitamin D receptor Homo sapiens 35-38 25447737-9 2015 hnRNPC, has been shown to be involved in the VDR transcriptional complex as a vitamin D-response element-binding protein (VDRE-BP), and may act as a coupling factor linking VDR-directed gene transcription with RNA splicing. Vitamin D 78-87 vitamin D receptor Homo sapiens 45-48 25447737-9 2015 hnRNPC, has been shown to be involved in the VDR transcriptional complex as a vitamin D-response element-binding protein (VDRE-BP), and may act as a coupling factor linking VDR-directed gene transcription with RNA splicing. Vitamin D 78-87 vitamin D receptor Homo sapiens 122-125 25448743-1 2015 Topical 1,25-dihydroxyvitamin D (1,25D) and other vitamin D compounds have been shown to protect skin from damage by ultraviolet radiation (UVR) in a process that requires the vitamin D receptor. Vitamin D 22-31 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 176-194 25448744-12 2015 Of importance in the observation is that several regulatory effects are deranged in the presence of hyperglycemia, particularly the PTH- and vitamin D-dependent up regulation of VDR and 1OHase in these cells. Vitamin D 141-150 vitamin D receptor Homo sapiens 178-181 25500070-9 2015 Real-time RT-PCR analysis confirmed that selected genes such as Abra, Apoa4, Fabp2, Hsd17b2, and Hspa1b affected by uremia were normalized by the vitamin D analogs with alfacalcidol exhibiting less of an effect. Vitamin D 146-155 actin-binding Rho activating protein Rattus norvegicus 64-68 25500070-9 2015 Real-time RT-PCR analysis confirmed that selected genes such as Abra, Apoa4, Fabp2, Hsd17b2, and Hspa1b affected by uremia were normalized by the vitamin D analogs with alfacalcidol exhibiting less of an effect. Vitamin D 146-155 fatty acid binding protein 2 Rattus norvegicus 77-82 25576905-0 2015 VDR FokI polymorphism is associated with a reduced T-helper cell population under vitamin D stimulation in type 1 diabetes patients. Vitamin D 82-91 vitamin D receptor Homo sapiens 0-3 25576905-2 2015 Additionally, the immune system regulator vitamin D, exerts its modulatory effects through the vitamin D receptor (VDR) expressed in Th cells. Vitamin D 42-51 vitamin D receptor Homo sapiens 95-113 25576905-2 2015 Additionally, the immune system regulator vitamin D, exerts its modulatory effects through the vitamin D receptor (VDR) expressed in Th cells. Vitamin D 42-51 vitamin D receptor Homo sapiens 115-118 25597951-8 2015 VDR mRNA and protein levels were lower (-65% and -90%) in the colon of CAC; APC(Delta580/Delta580) mice compared to control mice, suggesting loss of colon responsiveness to vitamin D. Vitamin D 173-182 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 0-3 25603468-7 2015 Consistently, colonic epithelial VDR levels are markedly reduced in patients with inflammatory bowel diseases or in experimental colitis models, whereas vitamin D analog therapy that ameliorates colitis up-regulates epithelial VDR. Vitamin D 153-162 vitamin D receptor Homo sapiens 227-230 25815722-0 2015 Vitamin D prevents hypoxia/reoxygenation-induced blood-brain barrier disruption via vitamin D receptor-mediated NF-kB signaling pathways. Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 84-102 25799011-3 2015 We selected 11 vitamin D-related genes (GC, DHCR7, CYP2R1, VDR, CYP27B1, CYP24A1, CYP27A1, RXRA, CRP2, CASR and CUBN) totaling 213 single nucleotide polymorphisms (SNPs), and examined associations with pancreatic adenocarcinoma. Vitamin D 15-24 7-dehydrocholesterol reductase Homo sapiens 44-49 25799011-3 2015 We selected 11 vitamin D-related genes (GC, DHCR7, CYP2R1, VDR, CYP27B1, CYP24A1, CYP27A1, RXRA, CRP2, CASR and CUBN) totaling 213 single nucleotide polymorphisms (SNPs), and examined associations with pancreatic adenocarcinoma. Vitamin D 15-24 vitamin D receptor Homo sapiens 59-62 25799011-3 2015 We selected 11 vitamin D-related genes (GC, DHCR7, CYP2R1, VDR, CYP27B1, CYP24A1, CYP27A1, RXRA, CRP2, CASR and CUBN) totaling 213 single nucleotide polymorphisms (SNPs), and examined associations with pancreatic adenocarcinoma. Vitamin D 15-24 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 73-80 25799011-3 2015 We selected 11 vitamin D-related genes (GC, DHCR7, CYP2R1, VDR, CYP27B1, CYP24A1, CYP27A1, RXRA, CRP2, CASR and CUBN) totaling 213 single nucleotide polymorphisms (SNPs), and examined associations with pancreatic adenocarcinoma. Vitamin D 15-24 retinoid X receptor alpha Homo sapiens 91-95 25542806-2 2015 Recently, variants of vitamin D metabolizing genes, including rs12368653, rs10876994, rs118204009 and rs703842 in CYP27B1, and rs2248359 in CYP24A1 have been identified to be associated with the pathogenicity of MS in Caucasian populations. Vitamin D 22-31 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 140-147 25519225-7 2015 Mechanistic studies indicated that the selective toxicity of miR-17~92 polycistron inactivation was the consequence of derepression of vitamin D signaling via suppression of CYP24A1, a rate-limiting enzyme in the 1alpha,25-dihydroxyvitamin D3 metabolic pathway. Vitamin D 135-144 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 174-181 31358030-3 2019 Vitamin D exerts its functions through the vitamin D receptor (VDR), and the aim of the current study was to investigate if the expression of VDR in invasive breast tumors is associated with breast cancer prognosis. Vitamin D 0-9 vitamin D receptor Homo sapiens 43-61 31358030-3 2019 Vitamin D exerts its functions through the vitamin D receptor (VDR), and the aim of the current study was to investigate if the expression of VDR in invasive breast tumors is associated with breast cancer prognosis. Vitamin D 0-9 vitamin D receptor Homo sapiens 63-66 31358030-3 2019 Vitamin D exerts its functions through the vitamin D receptor (VDR), and the aim of the current study was to investigate if the expression of VDR in invasive breast tumors is associated with breast cancer prognosis. Vitamin D 0-9 vitamin D receptor Homo sapiens 142-145 31357732-3 2019 Genetic variants close to genes that encode crucial enzymes for the synthesis (DHCR7 rs12785878), metabolism (CYP2R1 rs2060793) and degradation (CYP24A1 rs6013897) of vitamin D have been associated with serum levels of vitamin D. Vitamin D 167-176 7-dehydrocholesterol reductase Homo sapiens 79-84 31357732-3 2019 Genetic variants close to genes that encode crucial enzymes for the synthesis (DHCR7 rs12785878), metabolism (CYP2R1 rs2060793) and degradation (CYP24A1 rs6013897) of vitamin D have been associated with serum levels of vitamin D. Vitamin D 167-176 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 145-152 31357732-3 2019 Genetic variants close to genes that encode crucial enzymes for the synthesis (DHCR7 rs12785878), metabolism (CYP2R1 rs2060793) and degradation (CYP24A1 rs6013897) of vitamin D have been associated with serum levels of vitamin D. Vitamin D 219-228 7-dehydrocholesterol reductase Homo sapiens 79-84 31357732-3 2019 Genetic variants close to genes that encode crucial enzymes for the synthesis (DHCR7 rs12785878), metabolism (CYP2R1 rs2060793) and degradation (CYP24A1 rs6013897) of vitamin D have been associated with serum levels of vitamin D. Vitamin D 219-228 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 145-152 31357732-8 2019 These findings suggest that DHCR7 polymorphisms may be associated with an increased risk of thyroid cancer due to an effect of this gene on circulating vitamin D levels. Vitamin D 152-161 7-dehydrocholesterol reductase Homo sapiens 28-33 31386628-2 2019 Hypomorphic mutant Klotho [kl/kl] mice on C57BL/6xC3H, BALB/c and 129 genetic backgrounds, show decreased Klotho expression that correlate with accelerated aging including pre-mature death due to abnormally high levels of serum vitamin D. Vitamin D 228-237 klotho Mus musculus 19-25 31497480-0 2019 Profound vitamin D deficiency in four siblings with Imerslund-Grasbeck syndrome with homozygous CUBN mutation. Vitamin D 9-18 cubilin Homo sapiens 96-100 31497480-13 2019 Low vitamin D could be explained by cubilin being involved in reabsorption of vitamin carriers. Vitamin D 4-13 cubilin Homo sapiens 36-43 31363484-17 2019 Conclusion: We report a series of diabetic and hypertensive retinopathy cases with MTHFR polymorphisms and the improvement of retinal microvasculature (mainly MAs) in serial fundus photography after taking a medical food or supplement containing L-methylfolate and vitamin D. Vitamin D 265-274 methylenetetrahydrofolate reductase Homo sapiens 83-88 31379807-5 2019 Using rheumatoid arthritis (RA) as a model of autoimmune disease, we here demonstrate that pro-inflammatory memory CCR6+ Th cells can switch into anti-inflammatory cells with regulatory capacity using the active vitamin D metabolite 1,25(OH)2D3. Vitamin D 212-221 C-C motif chemokine receptor 6 Homo sapiens 115-119 31295336-8 2019 Association of AmB/LE and vitamin D deficiency led to diminished glomerular filtration rate and increased tubular injury, evidenced by reduced renal protein expression of NaPi-IIa and TRPM6 leading to hyperphosphaturia / hypermagnesuria. Vitamin D 26-35 transient receptor potential cation channel, subfamily M, member 6 Rattus norvegicus 184-189 30965119-0 2019 Presence of the vitamin D inactivating enzyme CYP24A1 in human sperm and prediction of the success of intrauterine insemination: A prospective study. Vitamin D 16-25 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 46-53 25887475-1 2015 BACKGROUND: The vitamin D receptor (VDR) mediates the major cellular activities of vitamin D and regulates various signaling pathways implicated in cancer development and progression. Vitamin D 16-25 vitamin D receptor Homo sapiens 36-39 31281179-9 2019 At the molecular levels, administration of vitamin D activated the expression of VDR and reduced the number of dead cells in the CA1 region of the hippocampus as well as regulated caspase-3 and Bcl-2 expression. Vitamin D 43-52 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 81-84 31281179-9 2019 At the molecular levels, administration of vitamin D activated the expression of VDR and reduced the number of dead cells in the CA1 region of the hippocampus as well as regulated caspase-3 and Bcl-2 expression. Vitamin D 43-52 caspase 3 Mus musculus 180-189 25620699-1 2015 The bioactive form of vitamin D [1,25(OH)2D3] regulates mineral and bone homeostasis and exerts potent anti-inflammatory and antiproliferative properties through binding to the vitamin D receptor (VDR). Vitamin D 22-31 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 177-195 31053643-8 2019 These findings define a finely balanced homeostatic mechanism involving PTH and FGF23 together with protection from 1,25(OH)2D3 toxicity that is responsible for both adaptive vitamin D metabolism and mineral regulation. Vitamin D 175-184 fibroblast growth factor 23 Mus musculus 80-85 25620699-1 2015 The bioactive form of vitamin D [1,25(OH)2D3] regulates mineral and bone homeostasis and exerts potent anti-inflammatory and antiproliferative properties through binding to the vitamin D receptor (VDR). Vitamin D 22-31 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 197-200 25667460-6 2015 All cell lines demonstrated large increases in CYP24A1 mRNA levels under vitamin D treatment but there was little change in CYP27B1 or VDR mRNA levels. Vitamin D 73-82 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 47-54 30977086-0 2019 Strong association between VDR FokI (rs2228570) gene variant and serum vitamin D levels in Turkish Cypriots. Vitamin D 71-80 vitamin D receptor Homo sapiens 27-30 25667460-8 2015 This could be due to large inactivation of vitamin D by CYP24A1 or by another mechanism. Vitamin D 43-52 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 56-63 25597001-5 2015 End-stage renal disease (ESRD) is also associated with a decrease in vitamin D activity by mechanisms including the increase of plasma phosphate concentration, secretion of FGF-23 and decrease in 1alpha-hydroxylase activity. Vitamin D 69-78 fibroblast growth factor 23 Homo sapiens 173-179 30977086-5 2019 In this study the four most common VDR polymorphisms (rs1544410 (BsmI), rs731236 (TaqI), rs7975232 (ApaI) and rs2228570 (FokI)) are investigated in a cohort of Turkish Cypriots and aimed to detect any possible links between low serum vitamin D levels and these variants. Vitamin D 234-243 vitamin D receptor Homo sapiens 35-38 30685787-8 2019 I/R injury affected the fibroblast growth factor 23 (FGF23)-klotho-vitamin D axis by increasing plasma levels of FGF23 and downregulation of renal klotho expression. Vitamin D 67-76 fibroblast growth factor 23 Mus musculus 24-51 25270396-2 2015 Elevated fibroblast growth factor (FGF)-23 in cyclosporine A (CsA) users with SLE are associated with decreased active vitamin D and osteocalcin. Vitamin D 119-128 fibroblast growth factor 23 Homo sapiens 9-42 25630909-5 2015 Furthermore, the mRNAs of natriuretic peptides, neutrophil gelatinase-associated lipocalin, hREN, and rRen were increased by vitamin D depletion. Vitamin D 125-134 lipocalin 2 Homo sapiens 48-90 25451947-0 2015 Serum free 1,25-dihydroxy-vitamin D is more closely associated with fibroblast growth factor 23 than other vitamin D forms in chronic dialysis patients. Vitamin D 26-35 fibroblast growth factor 23 Homo sapiens 68-95 25451947-2 2015 However, relationship between different forms of vitamin D and fibroblast growth factor 23 (FGF-23) remains unclear in this population. Vitamin D 49-58 fibroblast growth factor 23 Homo sapiens 63-90 25451947-2 2015 However, relationship between different forms of vitamin D and fibroblast growth factor 23 (FGF-23) remains unclear in this population. Vitamin D 49-58 fibroblast growth factor 23 Homo sapiens 92-98 30685787-8 2019 I/R injury affected the fibroblast growth factor 23 (FGF23)-klotho-vitamin D axis by increasing plasma levels of FGF23 and downregulation of renal klotho expression. Vitamin D 67-76 fibroblast growth factor 23 Mus musculus 53-58 25451947-10 2015 CONCLUSION: The relationship between FGF-23 and vitamin D is stronger using free forms of 25-OH-D and 1,25-(OH)2-D. Vitamin D 48-57 fibroblast growth factor 23 Homo sapiens 37-43 30685787-8 2019 I/R injury affected the fibroblast growth factor 23 (FGF23)-klotho-vitamin D axis by increasing plasma levels of FGF23 and downregulation of renal klotho expression. Vitamin D 67-76 fibroblast growth factor 23 Mus musculus 113-118 25785055-7 2015 The salivary MMP 2, MMP 3, and MMP 9 levels of the patients with vitamin D and vitamin B12 treatment were lower than that in the patients without vitamin D and vitamin B12 treatment. Vitamin D 65-74 matrix metallopeptidase 9 Homo sapiens 31-36 31485552-4 2019 FGF23-mediated forms of hypophosphatemia are characterized by phosphaturia and low or low-normal calcitriol concentrations, and unlike nutritional rickets, these cannot be cured with nutritional vitamin D supplementation. Vitamin D 195-204 fibroblast growth factor 23 Homo sapiens 0-5 25279449-3 2015 Vitamin D seems to influence antiviral response in chronic hepatitis C and its pathway is controlled by polymorphic genes such as CYP27B1, CYP24A1 and VDR. Vitamin D 0-9 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 139-146 26078251-2 2015 Vitamin D receptor (VDR) is an intracellular hormone receptor that specifically binds to the biologically active form of vitamin D, 1-alpha, 25- dihydroxyvitamin D3 [1, 25(OH)2D], and mediates its effects. Vitamin D 121-130 vitamin D receptor Homo sapiens 0-18 26078251-2 2015 Vitamin D receptor (VDR) is an intracellular hormone receptor that specifically binds to the biologically active form of vitamin D, 1-alpha, 25- dihydroxyvitamin D3 [1, 25(OH)2D], and mediates its effects. Vitamin D 121-130 vitamin D receptor Homo sapiens 20-23 25773805-0 2015 Associations between vitamin D receptor (VDR) gene polymorphisms and colorectal cancer risk and effect modifications of dietary calcium and vitamin D in a Japanese population. Vitamin D 21-30 vitamin D receptor Homo sapiens 41-44 31485552-7 2019 Historically phosphate supplementation and therapy using analogs of highly active vitamin D (eg, calcitriol, alfacalcidol, paricalcitol, eldecalcitol) have been used to manage conditions involving hypophosphatemia; however, recently a neutralizing antibody for FGF23 (burosumab) has emerged as a promising treatment agent for FGF23-mediated disorders. Vitamin D 82-91 fibroblast growth factor 23 Homo sapiens 261-266 31485552-7 2019 Historically phosphate supplementation and therapy using analogs of highly active vitamin D (eg, calcitriol, alfacalcidol, paricalcitol, eldecalcitol) have been used to manage conditions involving hypophosphatemia; however, recently a neutralizing antibody for FGF23 (burosumab) has emerged as a promising treatment agent for FGF23-mediated disorders. Vitamin D 82-91 fibroblast growth factor 23 Homo sapiens 326-331 30730049-2 2019 The vitamin D receptor (VDR) has a crucial role in the pathogenesis of this disease because it mediates the functions of vitamin D in the immune system. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 30813741-1 2019 BACKGROUND: Fibroblast growth factor 23 (FGF23), a potent regulator of phosphate and vitamin D metabolism, is a new biomarker of kidney, bone and cardiovascular disorders. Vitamin D 85-94 fibroblast growth factor 23 Homo sapiens 12-39 30813741-1 2019 BACKGROUND: Fibroblast growth factor 23 (FGF23), a potent regulator of phosphate and vitamin D metabolism, is a new biomarker of kidney, bone and cardiovascular disorders. Vitamin D 85-94 fibroblast growth factor 23 Homo sapiens 41-46 31001917-2 2019 We sought to examine associations between genetic variants in VDR and additional genes from vitamin D biosynthesis and pathway targets (EGFR, UGT1A, UGT2A1/2, UGT2B, CYP3A4/5, CYP2R1, CYP27B1, CYP24A1, CYP11A1, and GC). Vitamin D 92-101 vitamin D receptor Homo sapiens 62-65 30833469-8 2019 Moreover, fasting upregulated the vitamin D catabolizing CYP24A1 in the kidney through the PGC-1alpha-ERRalpha pathway. Vitamin D 34-43 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 57-64 31071734-0 2019 Can Supplementation with Vitamin D Modify Thyroid Autoantibodies (Anti-TPO Ab, Anti-Tg Ab) and Thyroid Profile (T3, T4, TSH) in Hashimoto"s Thyroiditis? Vitamin D 25-34 thyroid peroxidase Homo sapiens 71-74 30478987-0 2019 Active vitamin D regulates macrophage M1/M2 phenotypes via the STAT-1-TREM-1 pathway in diabetic nephropathy. Vitamin D 7-16 signal transducer and activator of transcription 1 Homo sapiens 63-69 30478987-2 2019 This study aimed to investigate whether active vitamin D (VD) suppresses macrophage transition to the M1 phenotype via inhibiting the high glucose-induced STAT-1 phosphorylation to reduce TREM-1 expression. Vitamin D 47-56 signal transducer and activator of transcription 1 Homo sapiens 155-161 31039170-1 2019 BACKGROUND: Vitamin D may play a role in skeletal muscle because of the discovery of VDR in skeletal muscle. Vitamin D 12-21 vitamin D receptor Homo sapiens 85-88 31035488-1 2019 BACKGROUND: Epidemiological studies have suggested a survival benefit for hemodialysis patients on paricalcitol or calcitriol, but nutritional vitamin D supplementation of patients already on vitamin D receptor (VDR) activators is controversial. Vitamin D 143-152 vitamin D receptor Homo sapiens 192-210 31035488-4 2019 The patients with any vitamin D formulation had higher serum concentrations of 25-hydroxy vitamin D and fibroblast growth factor-23 and tended to have higher mortality rates (42% vs. 25%, p = 0.07). Vitamin D 22-31 fibroblast growth factor 23 Homo sapiens 104-131 30975133-1 2019 BACKGROUND: Evidence shows that low serum vitamin D concentrations account for an increased risk of obesity by inducing vitamin D receptor (VDR) hypofunction. Vitamin D 42-51 vitamin D receptor Homo sapiens 120-138 30975133-1 2019 BACKGROUND: Evidence shows that low serum vitamin D concentrations account for an increased risk of obesity by inducing vitamin D receptor (VDR) hypofunction. Vitamin D 42-51 vitamin D receptor Homo sapiens 140-143 30959822-1 2019 The vitamin D receptor (VDR) mediates vitamin D actions beyond bone health. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 30959822-8 2019 Cell proliferation assays corroborated this conjectured oppositional basal VDR activity, indicating that precise 1,25D dosage in target tissues might be essential for modulating vitamin D actions in human health. Vitamin D 178-187 vitamin D receptor Homo sapiens 75-78 30969078-2 2019 In our study we aimed to investigate the correlations among urothelial type bladder cancer polymorphisms, ApaI, BsmI, FokI, and TaqI, prevalently observed in the vitamin D receptor (VDR) gene and plasma vitamin D levels in a Turkish population. Vitamin D 162-171 vitamin D receptor Homo sapiens 182-185 31084433-6 2019 Other shared functions of vitamin A and vitamin D include the support of innate lymphoid cells that produce IL-22, suppression of IFN-gamma and IL-17 by T cells, and induction of regulatory T cells in the mucosal tissues. Vitamin D 40-49 interleukin 22 Homo sapiens 108-113 31084433-6 2019 Other shared functions of vitamin A and vitamin D include the support of innate lymphoid cells that produce IL-22, suppression of IFN-gamma and IL-17 by T cells, and induction of regulatory T cells in the mucosal tissues. Vitamin D 40-49 interleukin 17A Homo sapiens 144-149 29602956-0 2019 Effects of vitamin D supplementation on FGF23: a randomized-controlled trial. Vitamin D 11-20 fibroblast growth factor 23 Homo sapiens 40-45 30399417-11 2019 Overall, vitamin D deficient mice resolved NTHi infection faster with a faster resolution of local lung inflammation, possibly through upregulation of CRAMP. Vitamin D 9-18 cathelicidin antimicrobial peptide Mus musculus 151-156 30465855-2 2019 Here we report a novel mechanism of action of TGF-beta that promotes the counteracting activity of vitamin D; in two models of human epithelial-mesenchymal EMT transition we demonstrated for the first time that TGF-beta strongly induced the expression of vitamin D receptor (VDR) and that 1,25(OH)2D3 was able to contrast the TGF-beta-driven EMT transition by transcriptional modulation. Vitamin D 99-108 vitamin D receptor Homo sapiens 255-273 30465855-2 2019 Here we report a novel mechanism of action of TGF-beta that promotes the counteracting activity of vitamin D; in two models of human epithelial-mesenchymal EMT transition we demonstrated for the first time that TGF-beta strongly induced the expression of vitamin D receptor (VDR) and that 1,25(OH)2D3 was able to contrast the TGF-beta-driven EMT transition by transcriptional modulation. Vitamin D 99-108 vitamin D receptor Homo sapiens 275-278 30476590-0 2019 Vitamin D attenuates rhinovirus-induced expression of intercellular adhesion molecule-1 (ICAM-1) and platelet-activating factor receptor (PAFR) in respiratory epithelial cells. Vitamin D 0-9 intercellular adhesion molecule 1 Homo sapiens 54-87 30476590-0 2019 Vitamin D attenuates rhinovirus-induced expression of intercellular adhesion molecule-1 (ICAM-1) and platelet-activating factor receptor (PAFR) in respiratory epithelial cells. Vitamin D 0-9 intercellular adhesion molecule 1 Homo sapiens 89-95 30606768-10 2019 Collectively, these data show that the VDR and FBW7 are mutual cofactors, and provide a mechanistic basis for the cancer-preventive actions of vitamin D. Vitamin D 143-152 vitamin D receptor Homo sapiens 39-42 30606768-11 2019 IMPLICATIONS: The key findings show that the VDR and the E3 ligase FBW7 regulate each other"s functions in transcriptional regulation and control of protein turnover, respectively, and provide a molecular basis for cancer-preventive actions of vitamin D.Visual Overview: http://mcr.aacrjournals.org/content/17/3/709/F1.large.jpg. Vitamin D 244-253 vitamin D receptor Homo sapiens 45-48 30796319-7 2019 The associations among DHCR7, vitamin D and lipid profile followed a seasonal pattern, decreased DHCR7 (p = 0.008) and vitamin D (p < 0.001) and increased total-cholesterol (p = 0.025) being found in winter/spring. Vitamin D 119-128 7-dehydrocholesterol reductase Homo sapiens 23-28 30796319-8 2019 Increasing vitamin D upon TNFalpha-blockade paralleled RA clinical improvement (r = -0.610, p = 0.027) and DHCR7 elevation (r = 0.766, p = 0.002). Vitamin D 11-20 7-dehydrocholesterol reductase Homo sapiens 107-112 30796319-9 2019 In conclusion, vitamin D-related polymorphisms and DHCR7 are pivotal to understand the complex, seasonal associations between vitamin D and lipid profile in RA. Vitamin D 126-135 7-dehydrocholesterol reductase Homo sapiens 51-56 30287151-3 2019 Vitamin D exerts its pharmacological effects primarily via vitamin D receptor, whose activation inhibits the renin-angiotensin system, a key culprit for DN under hyperglycemia. Vitamin D 0-9 vitamin D receptor Homo sapiens 59-77 30287151-5 2019 Mechanistic studies reveal that pathways relevant to inflammation participate in the pathogenesis of DN, however, consumption of vitamin D-related products negatively regulates inflammatory response at multiple levels, indicated by inhibiting macrophage infiltration, nuclear factor-kappa B (NF-kappaB) activation, and production of such inflammatory mediators as transforming growth factor-beta(TGF-beta), monocyte chemoattractant protein 1(MCP-1), and regulated upon activation normal T cell expressed and secreted protein(RANTES). Vitamin D 129-138 C-C motif chemokine ligand 5 Homo sapiens 525-531 30760247-13 2019 CONCLUSIONS: Our preliminary data showed that the levels of the vitamin D-related cytokines IL-15 and IL-32 differed between active TB patients and LTBI subjects. Vitamin D 64-73 interleukin 15 Homo sapiens 92-97 30145365-3 2019 OBJECTIVES: To investigate associations of PUFA plasma levels and dietary intake with asthma and allergy at age 3 years in this ancillary study of the Vitamin D Antenatal Asthma Reduction Trial. Vitamin D 151-160 pumilio RNA binding family member 3 Homo sapiens 43-47 30145365-11 2019 Antenatal vitamin D could modulate the effect of early childhood PUFA on risk of asthma and allergy. Vitamin D 10-19 pumilio RNA binding family member 3 Homo sapiens 65-69 28825325-0 2019 Vitamin D attenuates cerebral artery remodeling through VDR/AMPK/eNOS dimer phosphorylation pathway after subarachnoid hemorrhage in rats. Vitamin D 0-9 nitric oxide synthase 3 Rattus norvegicus 65-69 30321476-0 2019 Gestational Vitamin D Supplementation Leads to Reduced Perinatal RXRA DNA Methylation: Results From the MAVIDOS Trial. Vitamin D 12-21 retinoid X receptor alpha Homo sapiens 65-69 30321476-1 2019 We have previously demonstrated inverse associations between maternal 25(OH)-vitamin D status and perinatal DNA methylation at the retinoid-X-receptor-alpha (RXRA) locus and between RXRA methylation and offspring bone mass. Vitamin D 77-86 retinoid X receptor alpha Homo sapiens 131-156 30321476-1 2019 We have previously demonstrated inverse associations between maternal 25(OH)-vitamin D status and perinatal DNA methylation at the retinoid-X-receptor-alpha (RXRA) locus and between RXRA methylation and offspring bone mass. Vitamin D 77-86 retinoid X receptor alpha Homo sapiens 158-162 30321476-2 2019 In this study, we used an existing randomized trial to test the hypothesis that maternal gestational vitamin D supplementation would lead to reduced perinatal RXRA locus DNA methylation. Vitamin D 101-110 retinoid X receptor alpha Homo sapiens 159-163 30594355-8 2019 Differential expression for genes associated with the vitamin D pathway such as CYP27A1, CYP27B1, vitamin D-binding protein (DBP), and IFNG was dependent upon infection status. Vitamin D 54-63 GC vitamin D binding protein Bos taurus 98-123 30594355-8 2019 Differential expression for genes associated with the vitamin D pathway such as CYP27A1, CYP27B1, vitamin D-binding protein (DBP), and IFNG was dependent upon infection status. Vitamin D 54-63 interferon gamma Bos taurus 135-139 30205156-3 2019 The major circulating form of vitamin D is 25(OH)D and both D2 and D3 forms are routinely measured by LC/MS/MS to assess vitamin D status, due to their relatively long half-lives and much higher concentrations compared to 1alpha,25(OH)2D. Vitamin D 121-130 immunoglobulin heavy diversity 2-15 Homo sapiens 60-69 30205156-11 2019 With the current extensive knowledge on the reactions and pathways of metabolism of vitamin D, especially those catalyzed by CYP24A1, CYP27A1, CYP27B1, CYP3A4 and CYP11A1, it is likely that many other of the resulting hydroxyvitamin D metabolites will be measured in human serum in the future, some contributing to a more detailed understanding of vitamin D status in health and disease. Vitamin D 84-93 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 125-132 30205156-11 2019 With the current extensive knowledge on the reactions and pathways of metabolism of vitamin D, especially those catalyzed by CYP24A1, CYP27A1, CYP27B1, CYP3A4 and CYP11A1, it is likely that many other of the resulting hydroxyvitamin D metabolites will be measured in human serum in the future, some contributing to a more detailed understanding of vitamin D status in health and disease. Vitamin D 225-234 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 125-132 30278216-2 2019 Since these physiological actions caused by active vitamin D are triggered by the specific interaction between the vitamin D receptor (VDR) and active vitamin D, many types of compounds have been developed as potent ligands against VDR. Vitamin D 51-60 vitamin D receptor Homo sapiens 115-133 30278216-2 2019 Since these physiological actions caused by active vitamin D are triggered by the specific interaction between the vitamin D receptor (VDR) and active vitamin D, many types of compounds have been developed as potent ligands against VDR. Vitamin D 51-60 vitamin D receptor Homo sapiens 135-138 30278216-2 2019 Since these physiological actions caused by active vitamin D are triggered by the specific interaction between the vitamin D receptor (VDR) and active vitamin D, many types of compounds have been developed as potent ligands against VDR. Vitamin D 51-60 vitamin D receptor Homo sapiens 232-235 30278216-2 2019 Since these physiological actions caused by active vitamin D are triggered by the specific interaction between the vitamin D receptor (VDR) and active vitamin D, many types of compounds have been developed as potent ligands against VDR. Vitamin D 115-124 vitamin D receptor Homo sapiens 135-138 30278216-2 2019 Since these physiological actions caused by active vitamin D are triggered by the specific interaction between the vitamin D receptor (VDR) and active vitamin D, many types of compounds have been developed as potent ligands against VDR. Vitamin D 115-124 vitamin D receptor Homo sapiens 232-235 30696596-1 2019 Unraveling the vitamin D - RANKL association. Vitamin D 15-24 TNF superfamily member 11 Homo sapiens 27-32 30696596-3 2019 The discovery of receptor activator of nuclear factor kB (RANK) and RANK binding ligand (RANKL) uncovered the bone homeostasis and molecular mechanism by which multiple compounds (including vitamin D) regulated osteoclast differentiation; a function mediated by osteoblastic cells and osteoclast-precursor cells. Vitamin D 190-199 TNF superfamily member 11 Homo sapiens 68-87 30696596-3 2019 The discovery of receptor activator of nuclear factor kB (RANK) and RANK binding ligand (RANKL) uncovered the bone homeostasis and molecular mechanism by which multiple compounds (including vitamin D) regulated osteoclast differentiation; a function mediated by osteoblastic cells and osteoclast-precursor cells. Vitamin D 190-199 TNF superfamily member 11 Homo sapiens 89-94 30696596-4 2019 HYPOTHESIS: In a country burdened by vitamin D deficiency, causal relation between hypovitaminosis D and GCTB was hypothesized based on the vitamin D mediated RANKL expression and osteoclastogenesis, as India is also a population with higher incidence of GCTB as compared to Western populations described in the literature. Vitamin D 140-149 TNF superfamily member 11 Homo sapiens 159-164 30696596-5 2019 The possibility of vitamin D regulated osteoclastogenesis in GCTB is postulated on the evidence from molecular research linking it to the RANK/RANKL/OPG pathway. Vitamin D 19-28 TNF superfamily member 11 Homo sapiens 143-148 30696596-5 2019 The possibility of vitamin D regulated osteoclastogenesis in GCTB is postulated on the evidence from molecular research linking it to the RANK/RANKL/OPG pathway. Vitamin D 19-28 basic transcription factor 3 pseudogene 11 Homo sapiens 149-152 30696596-11 2019 DISCUSSION: The differential expression of RANKL and OPG in response to levels of vitamin D has been established. Vitamin D 82-91 TNF superfamily member 11 Homo sapiens 43-48 30696596-11 2019 DISCUSSION: The differential expression of RANKL and OPG in response to levels of vitamin D has been established. Vitamin D 82-91 basic transcription factor 3 pseudogene 11 Homo sapiens 53-56 30678432-2 2019 Vitamin D has been hypothesized to lower the risk of breast cancer via the nuclearvitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 102-105 30809535-0 2019 Vitamin D Regulates the Expressions of AQP-1 and AQP-4 in Mice Kidneys. Vitamin D 0-9 aquaporin 4 Mus musculus 49-54 30809535-8 2019 In addition, AQP-1 was decreased in renal papilla and AQP-4 expressions were increased in proximal tubule by suppressing renin activity or supplement of Vitamin D analogue. Vitamin D 153-162 aquaporin 4 Mus musculus 54-59 30774661-2 2019 The purpose of this study was to determine the utility of bioavailable 25(OH)D in assessing vitamin D status when vitamin D-binding protein (VDBP) was significantly altered by pregnancy and liver cirrhosis (LC). Vitamin D 92-101 GC vitamin D binding protein Homo sapiens 114-139 30774661-2 2019 The purpose of this study was to determine the utility of bioavailable 25(OH)D in assessing vitamin D status when vitamin D-binding protein (VDBP) was significantly altered by pregnancy and liver cirrhosis (LC). Vitamin D 92-101 GC vitamin D binding protein Homo sapiens 141-145 30963970-10 2019 CONCLUSION: The presence of the TT allele of the SNP rs2228570 of the VDR gene and the SNP rs731236 of the CC genotype was associated with the presence of osteopenia and decreased bone mineral density alongside malfunctions of vitamin D. Vitamin D 227-236 vitamin D receptor Homo sapiens 70-73 30218750-1 2018 Vitamin D binding protein (VDBP) plays an important role in the immune modulation and pathogenesis of hepatitis C viral (HCV) infection by influencing serum vitamin D levels. Vitamin D 157-166 GC vitamin D binding protein Homo sapiens 27-31 30648951-1 2018 2alpha-modification on the vitamin D skeleton with a 2alpha-(omega-hydroxyalkyl) or 2alpha-(omega-hydroxyalkoxy) group improves vitamin D receptor (VDR) binding affinity, lengthens the half-life in target cells because of increased resistance to CYP24A1 metabolism, and enhances biological activity. Vitamin D 27-36 vitamin D receptor Homo sapiens 128-146 30648951-1 2018 2alpha-modification on the vitamin D skeleton with a 2alpha-(omega-hydroxyalkyl) or 2alpha-(omega-hydroxyalkoxy) group improves vitamin D receptor (VDR) binding affinity, lengthens the half-life in target cells because of increased resistance to CYP24A1 metabolism, and enhances biological activity. Vitamin D 27-36 vitamin D receptor Homo sapiens 148-151 30648951-1 2018 2alpha-modification on the vitamin D skeleton with a 2alpha-(omega-hydroxyalkyl) or 2alpha-(omega-hydroxyalkoxy) group improves vitamin D receptor (VDR) binding affinity, lengthens the half-life in target cells because of increased resistance to CYP24A1 metabolism, and enhances biological activity. Vitamin D 27-36 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 246-253 30729229-2 2019 Loss-of-function mutations in CYP24A1 result in impaired dehydroxylation of active vitamin D (calcitriol). Vitamin D 83-92 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 30-37 30557404-3 2018 In the vitamin D plus calcium group relative to control, in the crypt differentiation zone (upper 40% of crypts), mib-1 expression decreased 24% (P = 0.28); p21 expression alone and relative to mib-1 expression increased 29% (P = 0.06) and 73% (P = 0.06), respectively; and bax expression relative to mib-1 expression increased 58% (P = 0.21). Vitamin D 7-16 MIB E3 ubiquitin protein ligase 1 Homo sapiens 114-119 30557404-6 2018 These pilot study results support further investigation of whether 1) vitamin D and calcium promote colorectal epithelial cell differentiation, reduce proliferation, and promote apoptosis in the normal-appearing human colorectal mucosa, 2) vitamin D and calcium act as chemopreventive agents against colorectal neoplasms, and 3) mib-1, p21, and bax are potential "treatable", pre-neoplastic, biomarkers of risk for colorectal neoplasms. Vitamin D 240-249 MIB E3 ubiquitin protein ligase 1 Homo sapiens 329-334 30092343-3 2018 Vitamin D activity is mediated by its receptor (VDR), which acts as a transcription factor modulating the expression of genes triggering the response against viruses. Vitamin D 0-9 vitamin D receptor Homo sapiens 48-51 30314996-0 2018 Vitamin D-induced vitamin D receptor expression induces tamoxifen sensitivity in MCF-7 stem cells via suppression of Wnt/beta-catenin signaling. Vitamin D 0-9 vitamin D receptor Homo sapiens 18-36 30314996-9 2018 Vitamin D enhanced VDR expression and induced DNA damage. Vitamin D 0-9 vitamin D receptor Homo sapiens 19-22 30314996-16 2018 Vitamin D-induced VDR expression increased the sensitivity of MCF-7 stem cells to tamoxifen by inhibiting Wnt/beta-catenin signaling. Vitamin D 0-9 vitamin D receptor Homo sapiens 18-21 30248338-3 2018 The authors transduced human hepatocyte-derived cells with an adenoviral vector encoding human VDR and found that angiopoietin-like protein 8 (ANGPTL8) expression was increased upon VDR activation by vitamin D or lithocholic acid. Vitamin D 200-209 vitamin D receptor Homo sapiens 95-98 30248338-3 2018 The authors transduced human hepatocyte-derived cells with an adenoviral vector encoding human VDR and found that angiopoietin-like protein 8 (ANGPTL8) expression was increased upon VDR activation by vitamin D or lithocholic acid. Vitamin D 200-209 angiopoietin like 8 Homo sapiens 114-141 30248338-3 2018 The authors transduced human hepatocyte-derived cells with an adenoviral vector encoding human VDR and found that angiopoietin-like protein 8 (ANGPTL8) expression was increased upon VDR activation by vitamin D or lithocholic acid. Vitamin D 200-209 angiopoietin like 8 Homo sapiens 143-150 30248338-3 2018 The authors transduced human hepatocyte-derived cells with an adenoviral vector encoding human VDR and found that angiopoietin-like protein 8 (ANGPTL8) expression was increased upon VDR activation by vitamin D or lithocholic acid. Vitamin D 200-209 vitamin D receptor Homo sapiens 182-185 29153269-3 2018 Plasma 25(OH)D levels and genetic variants in vitamin D pathway (NADSYN1/DHCR7, GC, CYP3A4, CYP2R1, CYP27A1, CYP27B1, VDR, CYP24A1, and LRP2) were measured using the blood sample collected at the first trimester. Vitamin D 46-55 NAD synthetase 1 Homo sapiens 65-72 29153269-8 2018 Variants of NADSYN1/DHCR7 were significantly associated with 25(OH)D concentrations among pregnant women without vitamin D supplements. Vitamin D 113-122 NAD synthetase 1 Homo sapiens 12-19 29153269-8 2018 Variants of NADSYN1/DHCR7 were significantly associated with 25(OH)D concentrations among pregnant women without vitamin D supplements. Vitamin D 113-122 7-dehydrocholesterol reductase Homo sapiens 20-25 30400332-5 2018 Two key observations validate this important non-classical action of vitamin D: first, vitamin D receptor (VDR) is expressed by the majority of immune cells, including B and T lymphocytes, monocytes, macrophages, and dendritic cells; second, there is an active vitamin D metabolism by immune cells that is able to locally convert 25(OH)D3 into 1,25(OH)2D3, its active form. Vitamin D 69-78 vitamin D receptor Homo sapiens 87-105 30400332-5 2018 Two key observations validate this important non-classical action of vitamin D: first, vitamin D receptor (VDR) is expressed by the majority of immune cells, including B and T lymphocytes, monocytes, macrophages, and dendritic cells; second, there is an active vitamin D metabolism by immune cells that is able to locally convert 25(OH)D3 into 1,25(OH)2D3, its active form. Vitamin D 69-78 vitamin D receptor Homo sapiens 107-110 30400332-5 2018 Two key observations validate this important non-classical action of vitamin D: first, vitamin D receptor (VDR) is expressed by the majority of immune cells, including B and T lymphocytes, monocytes, macrophages, and dendritic cells; second, there is an active vitamin D metabolism by immune cells that is able to locally convert 25(OH)D3 into 1,25(OH)2D3, its active form. Vitamin D 87-96 vitamin D receptor Homo sapiens 107-110 30268505-7 2018 Additionally, the binding affinity of the vitamin D analogs for the wild-type and the rickets-associated mutant R274L of VDR was evaluated. Vitamin D 42-51 vitamin D receptor Homo sapiens 121-124 30352957-0 2018 Summary Outcomes of the ODIN Project on Food Fortification for Vitamin D Deficiency Prevention. Vitamin D 63-72 ankyrin repeat and sterile alpha motif domain containing 1A Homo sapiens 24-28 30352957-1 2018 Food-based solutions for optimal vitamin D nutrition and health through the life cycle (ODIN) was a cross-disciplinary, collaborative project, including 30 partners from 19 countries, which aimed to develop evidence-based solutions to prevent low vitamin D status (25-hydroxyvitamin D (25(OH)D) < 30 nmol/L) using a food-first approach. Vitamin D 33-42 ankyrin repeat and sterile alpha motif domain containing 1A Homo sapiens 88-92 30352957-1 2018 Food-based solutions for optimal vitamin D nutrition and health through the life cycle (ODIN) was a cross-disciplinary, collaborative project, including 30 partners from 19 countries, which aimed to develop evidence-based solutions to prevent low vitamin D status (25-hydroxyvitamin D (25(OH)D) < 30 nmol/L) using a food-first approach. Vitamin D 247-256 ankyrin repeat and sterile alpha motif domain containing 1A Homo sapiens 88-92 30352957-10 2018 Using a series of food production studies, food-based RCTs and dietary modelling experiments, ODIN research shows that diverse fortification strategies could safely increase population intakes and prevent low vitamin D status. Vitamin D 209-218 ankyrin repeat and sterile alpha motif domain containing 1A Homo sapiens 94-98 30588186-6 2018 Our results show that melatonin and vitamin D are able to modulate ADSCs commitment towards osteogenic phenotype through the upregulation of HDAC1, SIRT 1 and 2, unfolding an epigenetic regulation in stem cell differentiation and opening novel strategies for future therapeutic balancing of stem cell fate toward adipogenic or osteogenic phenotype. Vitamin D 36-45 sirtuin 1 Homo sapiens 148-160 30326825-13 2018 CONCLUSIONS: These findings indicate that VDR expression is downregulated in HBV-transfected cells, thereby preventing vitamin D from inhibiting transcription and translation of HBV in vitro. Vitamin D 119-128 vitamin D receptor Homo sapiens 42-45 30300363-8 2018 In contrast, infection of IL-10-derived MPhi, similar to MPhi in lesions from patients with the progressive form of leprosy, resulted in induction of type I IFN and suppression of the vitamin D directed pathway. Vitamin D 184-193 interleukin 10 Homo sapiens 26-31 30405883-3 2018 In the general population, genetic variants affecting vitamin D metabolism (DHCR7 rs12785878, CYP2R1 rs10741657, GC rs4588) have been associated with serum vitamin D. Vitamin D 54-63 7-dehydrocholesterol reductase Homo sapiens 76-81 30405883-3 2018 In the general population, genetic variants affecting vitamin D metabolism (DHCR7 rs12785878, CYP2R1 rs10741657, GC rs4588) have been associated with serum vitamin D. Vitamin D 156-165 7-dehydrocholesterol reductase Homo sapiens 76-81 30405883-10 2018 In conclusion, DHCR7 rs12785878 and GC rs4588, but not CYP2R1 rs10741657, are significantly associated with vitamin D levels. Vitamin D 108-117 7-dehydrocholesterol reductase Homo sapiens 15-20 30286109-1 2018 The level of the vitamin D in the bloodstream is regulated by cytochrome P450 enzyme 24-hydroxylase A1 (CYP24A1). Vitamin D 17-26 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 62-102 30286109-1 2018 The level of the vitamin D in the bloodstream is regulated by cytochrome P450 enzyme 24-hydroxylase A1 (CYP24A1). Vitamin D 17-26 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 104-111 30286109-2 2018 Over expression of CYP24A1 enzyme is correlated with vitamin D deficiency and resistance to vitamin D therapy. Vitamin D 53-62 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 19-26 30286109-2 2018 Over expression of CYP24A1 enzyme is correlated with vitamin D deficiency and resistance to vitamin D therapy. Vitamin D 92-101 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 19-26 30286109-5 2018 Posner et al., (2010) first time reported two new vitamin D analogues namely CTA-091 and CTA-018 to inhibit CYP24A1. Vitamin D 50-59 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 108-115 29885880-5 2018 RESULTS: The structurally related vitamin D analogs calcipotriol and tacalcitiol, but not calcitriol itself, suppressed HCV replication in a VDR-dependent manner. Vitamin D 34-43 vitamin D receptor Homo sapiens 141-144 29885880-9 2018 CONCLUSION: Calcipotriol induces local structure rearrangements in VDR that could possibly translate into a superior clinical potential to execute important non-classical vitamin D effects such as inhibition of HCV replication. Vitamin D 171-180 vitamin D receptor Homo sapiens 67-70 29857077-3 2018 The VDR gene was found to regulate the immunomodulatory effects of vitamin D and it enhances the innate immunity system. Vitamin D 67-76 vitamin D receptor Homo sapiens 4-7 31729346-1 2018 Background Vitamin D deficiency is commonly identified in beta thalassemia major patients, related to iron accumulation.Vitamin D mediates its action upon binding to vitamin D receptor (VDR), a classical nuclear receptor. Vitamin D 11-20 vitamin D receptor Homo sapiens 166-184 31729346-1 2018 Background Vitamin D deficiency is commonly identified in beta thalassemia major patients, related to iron accumulation.Vitamin D mediates its action upon binding to vitamin D receptor (VDR), a classical nuclear receptor. Vitamin D 11-20 vitamin D receptor Homo sapiens 186-189 31729346-1 2018 Background Vitamin D deficiency is commonly identified in beta thalassemia major patients, related to iron accumulation.Vitamin D mediates its action upon binding to vitamin D receptor (VDR), a classical nuclear receptor. Vitamin D 120-129 vitamin D receptor Homo sapiens 166-184 31729346-1 2018 Background Vitamin D deficiency is commonly identified in beta thalassemia major patients, related to iron accumulation.Vitamin D mediates its action upon binding to vitamin D receptor (VDR), a classical nuclear receptor. Vitamin D 120-129 vitamin D receptor Homo sapiens 186-189 29339180-11 2018 However, since it inhibits the conversion of 25(OH)D to 1,25(OH)2D and VDR mRNA long-term, it could decrease the vitamin D response in adipocytes, leading to greater adipogenesis. Vitamin D 113-122 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 71-74 29944852-8 2018 The vitamin D treatments reduced the number of leukocytes in their BALF and they decreased the IL-6, IL-17, TGF-beta and MMP-9 levels and the abrogated collagenase deposits in their lung tissues. Vitamin D 4-13 interleukin 17A Mus musculus 101-106 30208925-7 2018 The methylation of the promoter regions of key genes in the vitamin D metabolic pathway (CYP24A1, CYP27A1, CYP27B1, CYP2R1, and VDR) was detected using the Illumina MiSeq platform. Vitamin D 60-69 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 89-96 30208925-7 2018 The methylation of the promoter regions of key genes in the vitamin D metabolic pathway (CYP24A1, CYP27A1, CYP27B1, CYP2R1, and VDR) was detected using the Illumina MiSeq platform. Vitamin D 60-69 vitamin D receptor Homo sapiens 128-131 30271381-2 2018 Sirtuin 1 histon deacethylase (SIRT1) links the vitamin D pathway with regulation of transcription factor FOXO3a, a key player in cell cycle regulation and apoptosis. Vitamin D 48-57 sirtuin 1 Homo sapiens 0-9 30271381-2 2018 Sirtuin 1 histon deacethylase (SIRT1) links the vitamin D pathway with regulation of transcription factor FOXO3a, a key player in cell cycle regulation and apoptosis. Vitamin D 48-57 sirtuin 1 Homo sapiens 31-36 30271381-3 2018 Aim of the present study was to investigate common single nucleotide polymorphisms (SNP"s) in FOXO3a gene in respect to thyroid diseases, as well as to evaluate the hypothesis of Sirtuin1-FOXO3a interaction being a mediator of anti-proliferative vitamin D effects. Vitamin D 246-255 sirtuin 1 Homo sapiens 179-187 30271381-11 2018 The dependency of anti-proliferative vitamin D effects on SIRT1 activity further suggests a key role of vitamin D-SIRT1-FOXO3a axis for protective vitamin D effects. Vitamin D 37-46 sirtuin 1 Homo sapiens 58-63 30271381-11 2018 The dependency of anti-proliferative vitamin D effects on SIRT1 activity further suggests a key role of vitamin D-SIRT1-FOXO3a axis for protective vitamin D effects. Vitamin D 37-46 sirtuin 1 Homo sapiens 114-119 30271381-11 2018 The dependency of anti-proliferative vitamin D effects on SIRT1 activity further suggests a key role of vitamin D-SIRT1-FOXO3a axis for protective vitamin D effects. Vitamin D 104-113 sirtuin 1 Homo sapiens 58-63 30271381-11 2018 The dependency of anti-proliferative vitamin D effects on SIRT1 activity further suggests a key role of vitamin D-SIRT1-FOXO3a axis for protective vitamin D effects. Vitamin D 104-113 sirtuin 1 Homo sapiens 114-119 30271381-11 2018 The dependency of anti-proliferative vitamin D effects on SIRT1 activity further suggests a key role of vitamin D-SIRT1-FOXO3a axis for protective vitamin D effects. Vitamin D 104-113 sirtuin 1 Homo sapiens 58-63 30271381-11 2018 The dependency of anti-proliferative vitamin D effects on SIRT1 activity further suggests a key role of vitamin D-SIRT1-FOXO3a axis for protective vitamin D effects. Vitamin D 104-113 sirtuin 1 Homo sapiens 114-119 30205552-1 2018 Vitamin D is a steroid-like hormone which acts by binding to vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 61-79 30205552-1 2018 Vitamin D is a steroid-like hormone which acts by binding to vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 81-84 34025836-13 2021 In UC, higher vitamin D concentrations were associated with lower IL-17 concentrations. Vitamin D 14-23 interleukin 17A Homo sapiens 66-71 29183808-2 2018 Vitamin D exerts its genomic actions via the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D3 receptor Cricetulus griseus 45-63 29183808-2 2018 Vitamin D exerts its genomic actions via the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D3 receptor Cricetulus griseus 65-68 30371149-2 2018 Supplementation with active vitamin D has been proposed to have vasoprotective potential in CKD , not only by direct effects on the endothelium but also by an increment of alpha-Klotho. Vitamin D 28-37 klotho Homo sapiens 178-184 30186518-9 2018 Key points: Vitamin D insufficiency prevalence is increasing worldwide and presents with similar comorbidities and risk factors to OSAS.The nonskeletal actions of vitamin D may contribute to the development of OSAS through immune system modulation, myopathy and inflammation.Studies evaluating serum vitamin D concentrations in OSAS patients and the effect of CPAP treatment report contradictory results, often influenced by confounding factors, such as obesity.There appears to be potential for use of vitamin D supplementation in OSAS patients as a means of reducing the incidence of cardiovascular disease, a comorbidity common in both conditions. Vitamin D 12-21 centromere protein J Homo sapiens 360-364 30186518-9 2018 Key points: Vitamin D insufficiency prevalence is increasing worldwide and presents with similar comorbidities and risk factors to OSAS.The nonskeletal actions of vitamin D may contribute to the development of OSAS through immune system modulation, myopathy and inflammation.Studies evaluating serum vitamin D concentrations in OSAS patients and the effect of CPAP treatment report contradictory results, often influenced by confounding factors, such as obesity.There appears to be potential for use of vitamin D supplementation in OSAS patients as a means of reducing the incidence of cardiovascular disease, a comorbidity common in both conditions. Vitamin D 163-172 centromere protein J Homo sapiens 360-364 29782843-6 2018 At physiological concentrations, active vitamin D maintains a normal rate of bone resorption and formation through the RANKL/OPG signal. Vitamin D 40-49 TNF superfamily member 11 Homo sapiens 119-124 29782843-6 2018 At physiological concentrations, active vitamin D maintains a normal rate of bone resorption and formation through the RANKL/OPG signal. Vitamin D 40-49 basic transcription factor 3 pseudogene 11 Homo sapiens 125-128 30018118-9 2018 Among the examined polymorphisms, DBP1 (rs7041) TT and CDX2 (rs11568820) AA/AG genotypes were markers of better prognosis, even with multivariate adjustment.Conclusions: In patients with NSCLC, vitamin D supplementation may improve survival of patients with early-stage lung adenocarcinoma with lower 25(OH)D levels. Vitamin D 194-203 caudal type homeobox 2 Homo sapiens 55-59 29633705-2 2018 Fibroblast growth factor 23 (FGF23) is a bone-derived hormone with a pivotal role in phosphorus and vitamin D metabolism. Vitamin D 100-109 fibroblast growth factor 23 Homo sapiens 0-27 29633705-2 2018 Fibroblast growth factor 23 (FGF23) is a bone-derived hormone with a pivotal role in phosphorus and vitamin D metabolism. Vitamin D 100-109 fibroblast growth factor 23 Homo sapiens 29-34 30274014-2 2018 Alteration of circulating vitamin D (VD) and its carrier vitamin D binding protein (VDBP) have been reported in certain types of cancers and may play a role in the course of the disease. Vitamin D 26-35 GC vitamin D binding protein Homo sapiens 57-82 30274014-2 2018 Alteration of circulating vitamin D (VD) and its carrier vitamin D binding protein (VDBP) have been reported in certain types of cancers and may play a role in the course of the disease. Vitamin D 26-35 GC vitamin D binding protein Homo sapiens 84-88 30246694-5 2018 RESULTS: Vitamin D supplementation significantly reduced the IL-17 and MDA serum levels (P<0.05) and observably increased the TAC and IL-10 serum levels (P<0.05), compared with the placebo group. Vitamin D 9-18 interleukin 17A Homo sapiens 61-66 30246694-5 2018 RESULTS: Vitamin D supplementation significantly reduced the IL-17 and MDA serum levels (P<0.05) and observably increased the TAC and IL-10 serum levels (P<0.05), compared with the placebo group. Vitamin D 9-18 interleukin 10 Homo sapiens 137-142 30246694-6 2018 Comparing different bowel habit subtypes, we observed that it was only in diarrhea predominant IBS (IBS-D) that vitamin D supplementation was able to significantly reduce the serum levels of TNF-alpha and IL-17 (P<0.05). Vitamin D 112-121 interleukin 17A Homo sapiens 205-210 30246694-7 2018 However, in all subtypes, IL-10 and TAC increased, while MDA decreased (P<0.05) in vitamin D group, compared to the placebo group. Vitamin D 86-95 interleukin 10 Homo sapiens 26-31 29861059-1 2018 Fibroblast growth factor 23 (FGF23) is a proteohormone regulating renal phosphate transport and vitamin D metabolism as well as inducing left heart hypertrophy. Vitamin D 96-105 fibroblast growth factor 23 Mus musculus 0-27 29861059-1 2018 Fibroblast growth factor 23 (FGF23) is a proteohormone regulating renal phosphate transport and vitamin D metabolism as well as inducing left heart hypertrophy. Vitamin D 96-105 fibroblast growth factor 23 Mus musculus 29-34 30200275-0 2018 Antiproliferative Activity of Non-Calcemic Vitamin D Analogs on Human Melanoma Lines in Relation to VDR and PDIA3 Receptors. Vitamin D 43-52 vitamin D receptor Homo sapiens 100-103 30200275-7 2018 On the other hand, the expression of VDR and its splicing variants and other vitamin D related genes (RXR, PDIA3, CYP3A4, CYP2R1, CYP27B1, CYP24A1 and CYP11A1) was detected in WM98 and A375 melanomas with the transcript levels being modulated by vitamin D analogs. Vitamin D 77-86 retinoid X receptor alpha Homo sapiens 102-105 30200275-7 2018 On the other hand, the expression of VDR and its splicing variants and other vitamin D related genes (RXR, PDIA3, CYP3A4, CYP2R1, CYP27B1, CYP24A1 and CYP11A1) was detected in WM98 and A375 melanomas with the transcript levels being modulated by vitamin D analogs. Vitamin D 246-255 vitamin D receptor Homo sapiens 37-40 29996894-9 2018 RESULTS: Of the CpGs in vitamin D-related genes, cg21201924 (RXRA) had the lowest p value for association with 25(OH)D (p = 0.0004). Vitamin D 24-33 retinoid X receptor alpha Homo sapiens 61-65 29987250-0 2018 Vitamin D"s Effect on the Proliferation and Inflammation of Human Intervertebral Disc Cells in Relation to the Functional Vitamin D Receptor Gene FokI Polymorphism. Vitamin D 0-9 vitamin D receptor Homo sapiens 122-140 30038585-7 2018 When the mice were challenged by a vitamin D deficient diet, serum FGF23 concentration and TRPV5 membrane abundance were decreased, but NCX1 abundance remained increased. Vitamin D 35-44 fibroblast growth factor 23 Mus musculus 67-72 30038585-7 2018 When the mice were challenged by a vitamin D deficient diet, serum FGF23 concentration and TRPV5 membrane abundance were decreased, but NCX1 abundance remained increased. Vitamin D 35-44 solute carrier family 8 (sodium/calcium exchanger), member 1 Mus musculus 136-140 30038585-8 2018 Collectively, renal distal calcium transport proteins (TRPV5 and Calbindin-D28k) in this model were altered by Memo- and vitamin-D dependent mechanisms, except for NCX1 which was vitamin D-independent. Vitamin D 121-130 calbindin 1 Mus musculus 65-79 29986424-1 2018 The vitamin D receptor (VDR) is a nuclear receptor that mediates the biological action of the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], and regulates calcium and bone metabolism. Vitamin D 4-13 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 24-27 29965969-5 2018 Both IL-15 and IL-10 induce MPhi differentiation, but IL-15 induces primary human monocytes to differentiate into antimicrobial MPhi (IL-15 MPhi) that robustly express the vitamin D pathway. Vitamin D 172-181 interleukin 15 Homo sapiens 54-59 29965969-5 2018 Both IL-15 and IL-10 induce MPhi differentiation, but IL-15 induces primary human monocytes to differentiate into antimicrobial MPhi (IL-15 MPhi) that robustly express the vitamin D pathway. Vitamin D 172-181 interleukin 15 Homo sapiens 54-59 29965969-6 2018 However, how vitamin D status alters IL-15 MPhi phenotype and function is unknown. Vitamin D 13-22 interleukin 15 Homo sapiens 37-42 29965969-8 2018 The presence of physiological levels of 25D during differentiation of IL-15 MPhi led to a significant vitamin D-dependent antimicrobial response against intracellular Mycobacterium leprae but did not change the phenotype or phagocytic function of these MPhi. Vitamin D 102-111 interleukin 15 Homo sapiens 70-75 29965969-9 2018 These data suggest that activation of the vitamin D pathway during IL-15 MPhi differentiation augments the antimicrobial response against M. leprae infection. Vitamin D 42-51 interleukin 15 Homo sapiens 67-72 29476020-8 2018 In presence of vitamin D receptor (VDR), DBP promoted cell aggression (invasion and doubling time) via activation of the insulin-like growth factor-1/insulin-like growth factor-binding protein-2/Akt axis, and induced suppression of vitamin D-responsive genes. Vitamin D 15-24 vitamin D receptor Homo sapiens 35-38 29574933-0 2018 The association of serum FGF23 and non-alcoholic fatty liver disease is independent of vitamin D in type 2 diabetes patients. Vitamin D 87-96 fibroblast growth factor 23 Homo sapiens 25-30 29574933-11 2018 In conclusion, both high FGF23 and low vitamin D levels showed an independent relationship with NAFLD in Chinese T2DM patients, indicating that FGF23 and vitamin D function via different regulatory pathways in the liver. Vitamin D 39-48 fibroblast growth factor 23 Homo sapiens 144-149 29574933-11 2018 In conclusion, both high FGF23 and low vitamin D levels showed an independent relationship with NAFLD in Chinese T2DM patients, indicating that FGF23 and vitamin D function via different regulatory pathways in the liver. Vitamin D 154-163 fibroblast growth factor 23 Homo sapiens 25-30 29588137-6 2018 Serum and gamma glutamyl transferase (GGT) level was also significantly decreased compared to the baseline levels after 12 weeks of treatment with vitamin D. Vitamin D 147-156 gamma-glutamyltransferase 1 Homo sapiens 10-36 29588137-6 2018 Serum and gamma glutamyl transferase (GGT) level was also significantly decreased compared to the baseline levels after 12 weeks of treatment with vitamin D. Vitamin D 147-156 gamma-glutamyltransferase 1 Homo sapiens 38-41 29588137-8 2018 CONCLUSION: While significant reduction of serum alkaline phosphatase and GGT were seen with vitamin D and calcitriol supplementation from baseline levels, no beneficial effects was seen when comparing vitamin D, calcitriol and placebo groups at the end of trial. Vitamin D 93-102 gamma-glutamyltransferase 1 Homo sapiens 74-77 29130299-2 2018 A nuclear receptor (VDR) mediates vitamin D actions in a lot of organs like bowel, bone, kidney, breast, gonads, pancreas, brain, cardiovascular and immune systems. Vitamin D 34-43 vitamin D receptor Homo sapiens 20-23 29538679-12 2018 WIDER IMPLICATIONS OF THE FINDINGS: This study suggests that there is a relationship between AGEs and their receptors (RAGE and sRAGE) with vitamin D. Vitamin D 140-149 long intergenic non-protein coding RNA 914 Homo sapiens 119-123 29790402-1 2018 AIM: Vitamin D (VD) influences genetic expression through its receptor (VDR). Vitamin D 5-14 vitamin D receptor Homo sapiens 72-75 29501468-13 2018 In brain-dead patients, vitamin D serum levels correlated with plasma IL-8, IL-10 and IFN-gamma. Vitamin D 24-33 interleukin 10 Homo sapiens 76-81 29881333-6 2018 Vitamin D deficiency also attenuated the structure of small intestinal villi and decreased the expression of the tight junction protein between adjacent epithelial cells and the percentages of CD4+CD25+Foxp3+Treg cell in spleen and mesenteric lymph nodes. Vitamin D 0-9 CD4 antigen Mus musculus 193-196 30134801-0 2018 Dysequilibrium of the PTH-FGF23-vitamin D axis in relapsing remitting multiple sclerosis; a longitudinal study. Vitamin D 32-41 fibroblast growth factor 23 Homo sapiens 26-31 30134801-3 2018 We therefore sought evidence for dysregulation of the PTH-FGF23-vitamin D axis in RRMS. Vitamin D 64-73 fibroblast growth factor 23 Homo sapiens 58-63 30134801-12 2018 CONCLUSIONS: This study revealed a dysequilibrium of the PTH-FGF23-vitamin D axis in RRMS, with lower plasma PTH, higher plasma iFGF23 and a lower serum 1,25(OH)2D to 25OHD ratio in RRMS compared with HC subjects. Vitamin D 67-76 fibroblast growth factor 23 Homo sapiens 61-66 29760049-1 2018 Fibroblast growth factor 23 (FGF23) is produced by bone cells and regulates renal phosphate and vitamin D metabolism, as well as causing left ventricular hypertrophy. Vitamin D 96-105 fibroblast growth factor 23 Homo sapiens 0-27 29760049-1 2018 Fibroblast growth factor 23 (FGF23) is produced by bone cells and regulates renal phosphate and vitamin D metabolism, as well as causing left ventricular hypertrophy. Vitamin D 96-105 fibroblast growth factor 23 Homo sapiens 29-34 29886473-4 2018 The increased FGF23 levels gradually lead to myocardial hypertrophy, inflammatory, vascular calcification, and low level of vitamin D, which contribute to the progress of CKD, cardiovascular complications and even death. Vitamin D 124-133 fibroblast growth factor 23 Homo sapiens 14-19 29910802-10 2018 Vitamin D levels were insufficient in 50% of old individuals and correlated positively with total CD8+ T cells and negatively with CD8+ EMRA T cells. Vitamin D 0-9 CD8a molecule Homo sapiens 98-101 29910802-10 2018 Vitamin D levels were insufficient in 50% of old individuals and correlated positively with total CD8+ T cells and negatively with CD8+ EMRA T cells. Vitamin D 0-9 CD8a molecule Homo sapiens 131-134 29910802-12 2018 Considering the limitations of the study as size of the sample and lack of functional assays, it was found that vitamin D in old individuals was correlated to some features of the immune system, mainly in the CD8 compartment. Vitamin D 112-121 CD8a molecule Homo sapiens 209-212 29875733-3 2018 The model describes, how VDR"s spatio-temporal binding profile provides key insight into the pleiotropic action of vitamin D. Vitamin D 115-124 vitamin D receptor Homo sapiens 25-28 29875736-3 2018 Vitamin D-binding protein (VDBP) is one of the key biomolecules that optimize vitamin D homeostasis and also contributes as an immune regulator for a healthy, ongoing pregnancy. Vitamin D 78-87 GC vitamin D binding protein Homo sapiens 0-25 29875736-3 2018 Vitamin D-binding protein (VDBP) is one of the key biomolecules that optimize vitamin D homeostasis and also contributes as an immune regulator for a healthy, ongoing pregnancy. Vitamin D 78-87 GC vitamin D binding protein Homo sapiens 27-31 29795187-1 2018 Epidemiological studies have confirmed associations of the vitamin D receptor (VDR) and vitamin D-related gene polymorphisms with adiposity and other metabolic disturbances. Vitamin D 59-68 vitamin D receptor Homo sapiens 79-82 29951549-2 2018 1,25(OH)2D, the biologically active form of vitamin D, exerts most of its functions through the almost universally distributed nuclear vitamin D receptor (VDR). Vitamin D 44-53 vitamin D receptor Homo sapiens 135-153 29951549-2 2018 1,25(OH)2D, the biologically active form of vitamin D, exerts most of its functions through the almost universally distributed nuclear vitamin D receptor (VDR). Vitamin D 44-53 vitamin D receptor Homo sapiens 155-158 29951549-4 2018 In turn, VDR/RXR binds to DNA sequences termed vitamin D response elements in target genes, regulating gene transcription. Vitamin D 47-56 vitamin D receptor Homo sapiens 9-12 29951549-4 2018 In turn, VDR/RXR binds to DNA sequences termed vitamin D response elements in target genes, regulating gene transcription. Vitamin D 47-56 retinoid X receptor alpha Homo sapiens 13-16 30283909-2 2018 Activation of vitamin D by renal 1alpha-hydroxylation is dependent on protein binding because 1,25-dihydroxyvitamin D (1,25(OH)2D3) is formed after megalin-mediated reabsorption of 25-hydroxyvitamin D (25OHD) bound to vitamin D binding protein (DBP). Vitamin D 14-23 GC vitamin D binding protein Homo sapiens 218-243 29771914-0 2018 Regulation of vitamin D metabolizing enzymes in murine renal and extrarenal tissues by dietary phosphate, FGF23, and 1,25(OH)2D3. Vitamin D 14-23 fibroblast growth factor 23 Mus musculus 106-111 29771914-2 2018 Vitamin D is first modified in the liver by the 25-hydroxylases CYP2R1 and CYP27A1 and further activated in the kidney by the 1alpha-hydroxylase CYP27B1, while the renal 24-hydroxylase CYP24A1 catalyzes the first step of its inactivation. Vitamin D 0-9 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 185-192 29769621-7 2018 Progressive trends (P < 0.05) towards increased CD8 and CD4/CD8 were observed in vitamin-D-deficient T2DM and hypertension patients. Vitamin D 84-93 CD8a molecule Homo sapiens 51-54 29769621-7 2018 Progressive trends (P < 0.05) towards increased CD8 and CD4/CD8 were observed in vitamin-D-deficient T2DM and hypertension patients. Vitamin D 84-93 CD8a molecule Homo sapiens 63-66 29769621-8 2018 Significant differences (P < 0.05) in CD8 were observed in vitamin-D-deficient CAD patients, whereas significant differences (P < 0.05) in CD8 and CD19 were observed in CRVD patients. Vitamin D 62-71 CD8a molecule Homo sapiens 41-44 29769621-10 2018 Increases in CD8-positive lymphocytes suggested a similar, less pronounced effect in vitamin-D-deficient CRVD and CAD patients. Vitamin D 85-94 CD8a molecule Homo sapiens 13-16 29686092-8 2018 We hypothesize that selection on EDAR V370A occurred in the Beringian refugium because it increases mammary ductal branching, and thereby may amplify the transfer of critical nutrients in vitamin D-deficient conditions to infants via mothers" milk. Vitamin D 188-197 ectodysplasin A receptor Homo sapiens 33-37 29686092-9 2018 This hypothesized selective context for EDAR V370A was likely intertwined with selection on the fatty acid desaturase (FADS) gene cluster because it is known to modulate lipid profiles transmitted to milk from a vitamin D-rich diet high in omega-3 fatty acids. Vitamin D 212-221 ectodysplasin A receptor Homo sapiens 40-44 29686092-9 2018 This hypothesized selective context for EDAR V370A was likely intertwined with selection on the fatty acid desaturase (FADS) gene cluster because it is known to modulate lipid profiles transmitted to milk from a vitamin D-rich diet high in omega-3 fatty acids. Vitamin D 212-221 stearoyl-CoA desaturase Homo sapiens 96-117 29686092-9 2018 This hypothesized selective context for EDAR V370A was likely intertwined with selection on the fatty acid desaturase (FADS) gene cluster because it is known to modulate lipid profiles transmitted to milk from a vitamin D-rich diet high in omega-3 fatty acids. Vitamin D 212-221 stearoyl-CoA desaturase Homo sapiens 119-123 29432829-3 2018 With respect to cancer, the genomic actions of vitamin D are mediated through binding to the Vitamin D Receptor (VDR), which allows it to modulate the expression of genes in a cell-and tissue-specific manner. Vitamin D 47-56 vitamin D receptor Homo sapiens 93-111 29432829-3 2018 With respect to cancer, the genomic actions of vitamin D are mediated through binding to the Vitamin D Receptor (VDR), which allows it to modulate the expression of genes in a cell-and tissue-specific manner. Vitamin D 47-56 vitamin D receptor Homo sapiens 113-116 29720668-1 2018 Fibroblast growth factor 23 (FGF23) plays critical roles in phosphate handling and vitamin D metabolism in the kidney. Vitamin D 83-92 fibroblast growth factor 23 Mus musculus 0-27 29720668-1 2018 Fibroblast growth factor 23 (FGF23) plays critical roles in phosphate handling and vitamin D metabolism in the kidney. Vitamin D 83-92 fibroblast growth factor 23 Mus musculus 29-34 29486367-13 2018 CONCLUSIONS: After a 14-day lag, a single high dose of vitamin D led to greater production of 24,25(OH)2D3, presumably via induction of the 24-hydroxylase enzyme (CYP24A1), relative to the 25(OH)D3 value than did daily vitamin D supplementation, and this effect persisted for at least 28days after vitamin D administration. Vitamin D 55-64 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 163-170 29786188-1 2018 Mutations of the CYP24A1 gene are associated with alterations in the activity of the enzyme 25-OH-D-24-hydroxylase, resulting in dysfunction of the metabolism of vitamin D. Vitamin D 162-171 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 17-24 29461981-1 2018 Genetic forms of vitamin D-dependent rickets (VDDRs) are due to mutations impairing activation of vitamin D or decreasing vitamin D receptor responsiveness. Vitamin D 17-26 vitamin D receptor Homo sapiens 122-140 29461981-4 2018 In vitro, the mutant CYP3A4 oxidized 1,25-dihydroxyvitamin D with 10-fold greater activity than WT CYP3A4 and 2-fold greater activity than CYP24A1, the principal inactivator of vitamin D metabolites. Vitamin D 51-60 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 139-146 29528271-3 2018 Therefore, the objective of this study was to investigate the association between polymorphisms of vitamin D metabolizing enzymes (rs927650 SNP in CYP24A1, and rs10741657 SNP in CYP2R1 genes,) and ischemic stroke risk in Turkish population. Vitamin D 99-108 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 147-154 29080365-2 2018 Narrow-band UVB (NB-UVB) treatment of vitiligo might act through its effects on vitamin D and its receptor.This study is the first to elucidate NB-UVB effects on immunohistochemical vitamin D receptor (VDR) expression in generalized vitiligo and correlate it with serum vitamin D and repigmentation response. Vitamin D 80-89 vitamin D receptor Homo sapiens 182-200 29080365-2 2018 Narrow-band UVB (NB-UVB) treatment of vitiligo might act through its effects on vitamin D and its receptor.This study is the first to elucidate NB-UVB effects on immunohistochemical vitamin D receptor (VDR) expression in generalized vitiligo and correlate it with serum vitamin D and repigmentation response. Vitamin D 182-191 vitamin D receptor Homo sapiens 202-205 29281615-9 2018 The vitamin D/VDR pathway protects against intestinal injury of NEC partly through suppressing the expression of TLR4. Vitamin D 4-13 vitamin D receptor Homo sapiens 14-17 29669566-3 2018 Vitamin D acts in tissues through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 38-56 29669566-3 2018 Vitamin D acts in tissues through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 58-61 29388391-8 2018 BAZ1A has been associated with neurodevelopmental impairment and dysregulation of several pathways including vitamin D metabolism. Vitamin D 109-118 bromodomain adjacent to zinc finger domain 1A Homo sapiens 0-5 29719821-7 2018 SLC37A1 seems to be required for lipid biosynthesis in cancer cell lines, SLC37A2 has been proposed as a vitamin D and a phospho-progesterone receptor target gene, while mutations in the SLC37A3 gene appear to be associated with congenital hyperinsulinism of infancy. Vitamin D 105-114 solute carrier family 37 member 2 Homo sapiens 74-81 29657326-3 2018 Vitamin D, as a prohormone, undergoes two-step metabolism in liver and kidney to produce a biologically active metabolite, calcitriol, which binds to the vitamin D receptor (VDR) for the regulation of expression of diverse genes. Vitamin D 0-9 vitamin D receptor Homo sapiens 154-172 29657326-3 2018 Vitamin D, as a prohormone, undergoes two-step metabolism in liver and kidney to produce a biologically active metabolite, calcitriol, which binds to the vitamin D receptor (VDR) for the regulation of expression of diverse genes. Vitamin D 0-9 vitamin D receptor Homo sapiens 174-177 29599772-0 2018 The Gut Microbiota Regulates Endocrine Vitamin D Metabolism through Fibroblast Growth Factor 23. Vitamin D 39-48 fibroblast growth factor 23 Mus musculus 68-95 29599772-11 2018 The microbiota through FGF23 regulates vitamin D metabolism. Vitamin D 39-48 fibroblast growth factor 23 Mus musculus 23-28 29467039-2 2018 The vitamin D plays a key role in regulation of calcium homeostasis and bone mineralization, exerting its biological activities by binding to a high-affinity receptor (VDR). Vitamin D 4-13 vitamin D receptor Homo sapiens 168-171 29128634-3 2018 Vitamin D plays an important role in immune response modulation and its action occurs through the vitamin D receptor (VDR), which recently has been described as overexpressed in human placenta during the pregnancy. Vitamin D 0-9 vitamin D receptor Homo sapiens 98-116 29128634-3 2018 Vitamin D plays an important role in immune response modulation and its action occurs through the vitamin D receptor (VDR), which recently has been described as overexpressed in human placenta during the pregnancy. Vitamin D 0-9 vitamin D receptor Homo sapiens 118-121 29233860-4 2018 Vitamin D receptor (VDR) expression is common to multiple immune cell types, and thus, pathway analysis of gene expression using data from multiple related models provides an inclusive perspective on the immunomodulatory impact of vitamin D. Vitamin D 231-240 vitamin D receptor Homo sapiens 0-18 29382742-7 2018 These findings uncover an important link between androgens and vitamin D homeostasis and suggest that therapeutic modulation of Pgr may be used to treat vitamin D deficiency and related disorders. Vitamin D 63-72 progesterone receptor Mus musculus 128-131 29510848-3 2018 The groups were formed according to BTMD data, ethnic affiliation and according to content of vitamin D and gene polymorphism of vitamin D (VDR). Vitamin D 129-138 vitamin D receptor Homo sapiens 140-143 29416220-2 2018 Vitamin D shows its effects on the immune system with the vitamin D receptor (VDR) in the nucleus. Vitamin D 0-9 vitamin D receptor Homo sapiens 58-76 29416220-2 2018 Vitamin D shows its effects on the immune system with the vitamin D receptor (VDR) in the nucleus. Vitamin D 0-9 vitamin D receptor Homo sapiens 78-81 29416220-3 2018 Single nucleotide polymorphisms (SNPs) in the VDR gene can lead to alterations in vitamin D functions and metabolism.Taq I, Apa I, Fok I and Bsm I polymorphisms and MS associations have been investigated in many studies. Vitamin D 82-91 vitamin D receptor Homo sapiens 46-49 29205876-2 2018 Here, we sought to study the impact of the vitamin D receptor (Vdr) on adipocyte size in young and old mice and the effect of maternal vitamin D deficiency on fetal adipogenesis. Vitamin D 43-52 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 63-66 29162485-13 2018 In astrocytes 3beta-HSD was also suppressed by vitamin D, about 20% at the enzyme activity level and 60% at the mRNA level. Vitamin D 47-56 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 14-23 29342138-2 2018 This commits FGFR to respond to FGF23, a key hormone in the regulation of mineral ion and vitamin D homeostasis. Vitamin D 90-99 fibroblast growth factor 23 Homo sapiens 32-37 29357898-1 2018 BACKGROUND: To determine longitudinally the relationship between serum 25-hydroxyvitamin D (vitamin D) and vitamin D-binding protein (DBP) levels in mother-neonate pairs and evaluate the efficiency of prophylactic vitamin D on lactation days 45-60. Vitamin D 81-90 GC vitamin D binding protein Homo sapiens 107-132 29357898-1 2018 BACKGROUND: To determine longitudinally the relationship between serum 25-hydroxyvitamin D (vitamin D) and vitamin D-binding protein (DBP) levels in mother-neonate pairs and evaluate the efficiency of prophylactic vitamin D on lactation days 45-60. Vitamin D 92-101 GC vitamin D binding protein Homo sapiens 107-132 29358755-2 2018 24-hydroxylase encoded by CYP24A1 is the enzyme that degrades the active vitamin D metabolite. Vitamin D 73-82 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 26-33 29351340-7 2018 HMB and vitamin D inhibited the serum IL-6 surge, downregulated the expression of MuRF1 and atrogin-1 in the soleus muscle, and ameliorated atrophy in the mice. Vitamin D 8-17 tripartite motif-containing 63 Mus musculus 82-87 29342166-12 2018 Consistently, a significantly decreased activation of the SCAP/SREBP lipogenic pathway and lower levels of CML protein adducts and RAGE expression were observed in skeletal muscle of animals treated with vitamin D. Vitamin D 204-213 SREBF chaperone Mus musculus 58-62 29342166-13 2018 Collectively, these data indicate that vitamin D-induced selective inhibition of signaling pathways (including NF-kappaB, SCAP/SREBP and CML/RAGE cascades) within the skeletal muscle significantly contributed to the beneficial effects of vitamin D supplementation against diet-induced metabolic derangements. Vitamin D 39-48 SREBF chaperone Mus musculus 122-126 29342166-13 2018 Collectively, these data indicate that vitamin D-induced selective inhibition of signaling pathways (including NF-kappaB, SCAP/SREBP and CML/RAGE cascades) within the skeletal muscle significantly contributed to the beneficial effects of vitamin D supplementation against diet-induced metabolic derangements. Vitamin D 238-247 SREBF chaperone Mus musculus 122-126 29032145-1 2018 Vitamin D has been established as a key factor in the development of obesity through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 89-107 29032145-1 2018 Vitamin D has been established as a key factor in the development of obesity through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 109-112 29375203-12 2018 Treatment of re-cultured PSCs with Dvitamins was associated with lower expression of IL-6 (-42% to -49%; P < 0.05; also confirmed at the protein level) and increased expression of the vitamin D receptor gene (209%-321% vs controls; P < 0.05). Vitamin D 35-44 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 187-205 29315215-2 2018 We conducted a Mendelian randomization analysis of the relationship between a vitamin D genetic risk score (GRS, range 0-10), comprised of five single nucleotide polymorphisms (SNPs) of vitamin D status in the DHCR7, CYP2R1 and GC genes and cancer risk among women. Vitamin D 78-87 7-dehydrocholesterol reductase Homo sapiens 210-215 29315215-2 2018 We conducted a Mendelian randomization analysis of the relationship between a vitamin D genetic risk score (GRS, range 0-10), comprised of five single nucleotide polymorphisms (SNPs) of vitamin D status in the DHCR7, CYP2R1 and GC genes and cancer risk among women. Vitamin D 186-195 7-dehydrocholesterol reductase Homo sapiens 210-215 29299028-9 2017 Along with the significant improvement of clinical symptoms, use of vitamin D increase FOXP3 gene expression and downregulation of IL-10, TGF-B, and FOXP3, IL-17, but these changes were not statistically significant. Vitamin D 68-77 interleukin 10 Homo sapiens 131-136 29299028-9 2017 Along with the significant improvement of clinical symptoms, use of vitamin D increase FOXP3 gene expression and downregulation of IL-10, TGF-B, and FOXP3, IL-17, but these changes were not statistically significant. Vitamin D 68-77 interleukin 17A Homo sapiens 156-161 29269725-6 2017 Through immunofluorescence staining and luciferase reporter assay, we found that Vitamin D Response Element (VDRE) affected IFN-activated site (Gamma-activated sequence, GAS) function at the transcriptional level and was involved in the inhibition of K17 expression. Vitamin D 81-90 keratin 17 Homo sapiens 251-254 29272316-4 2017 Many of vitamin D"s actions are mediated through vitamin D receptor (VDR). Vitamin D 8-17 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 49-67 29272316-4 2017 Many of vitamin D"s actions are mediated through vitamin D receptor (VDR). Vitamin D 8-17 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 69-72 29457022-1 2017 CYP24A1 is an enzyme that inactivates vitamin D. Vitamin D 38-47 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 0-7 29061851-0 2017 Hormonal vitamin D up-regulates tissue-specific PD-L1 and PD-L2 surface glycoprotein expression in humans but not mice. Vitamin D 9-18 programmed cell death 1 ligand 2 Homo sapiens 58-63 29021285-5 2017 Notably, in vitro experiments with trophoblasts showed increased production and secretion of 25(OH)D3 and higher CYP24A1 gene transcript abundance in response to cholecalciferol treatment.Conclusions: The numerous associations of many of the placental biomarkers of vitamin D metabolism with circulating vitamin D metabolites among pregnant women [including a CYP27B1-associated increase in 1,25(OH)2D3] and the evidence of trophoblast production and secretion of vitamin D metabolites, especially 25(OH)D3, suggest that the placenta may play an active role in modulating the vitamin D metabolite profile in maternal circulation in human pregnancy. Vitamin D 266-275 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 113-120 29021285-5 2017 Notably, in vitro experiments with trophoblasts showed increased production and secretion of 25(OH)D3 and higher CYP24A1 gene transcript abundance in response to cholecalciferol treatment.Conclusions: The numerous associations of many of the placental biomarkers of vitamin D metabolism with circulating vitamin D metabolites among pregnant women [including a CYP27B1-associated increase in 1,25(OH)2D3] and the evidence of trophoblast production and secretion of vitamin D metabolites, especially 25(OH)D3, suggest that the placenta may play an active role in modulating the vitamin D metabolite profile in maternal circulation in human pregnancy. Vitamin D 304-313 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 113-120 29021285-5 2017 Notably, in vitro experiments with trophoblasts showed increased production and secretion of 25(OH)D3 and higher CYP24A1 gene transcript abundance in response to cholecalciferol treatment.Conclusions: The numerous associations of many of the placental biomarkers of vitamin D metabolism with circulating vitamin D metabolites among pregnant women [including a CYP27B1-associated increase in 1,25(OH)2D3] and the evidence of trophoblast production and secretion of vitamin D metabolites, especially 25(OH)D3, suggest that the placenta may play an active role in modulating the vitamin D metabolite profile in maternal circulation in human pregnancy. Vitamin D 304-313 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 113-120 29021285-5 2017 Notably, in vitro experiments with trophoblasts showed increased production and secretion of 25(OH)D3 and higher CYP24A1 gene transcript abundance in response to cholecalciferol treatment.Conclusions: The numerous associations of many of the placental biomarkers of vitamin D metabolism with circulating vitamin D metabolites among pregnant women [including a CYP27B1-associated increase in 1,25(OH)2D3] and the evidence of trophoblast production and secretion of vitamin D metabolites, especially 25(OH)D3, suggest that the placenta may play an active role in modulating the vitamin D metabolite profile in maternal circulation in human pregnancy. Vitamin D 304-313 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 113-120 29301185-9 2017 Multivariate regression analysis revealed that daylight outdoor hours (beta=2.948, P=0.003) and vitamin D intake (beta=2.865, P=0.003) affected the 25(OH)D level; the presence of type 1 diabetes or urinary VDBP excretion was not significant. Vitamin D 96-105 GC vitamin D binding protein Homo sapiens 206-210 28830874-5 2017 We considered 82 SNPs in 7 vitamin D-related genes (CYP24A1, CYP27B1, CYP2R1, GC, DHCR7/NADSYN1, RXRA, and VDR). Vitamin D 27-36 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 52-59 28830874-8 2017 In gene-based tests, only VDR showed strong evidence of interaction (P = 0.04).Conclusions: SNPs in vitamin D-related genes may modify the association between serum 25(OH)D and breast cancer.Impact: This work strengthens the evidence for protective effects of vitamin D. Cancer Epidemiol Biomarkers Prev; 26(12); 1761-71. Vitamin D 100-109 vitamin D receptor Homo sapiens 26-29 28922293-4 2017 Data obtained in experimental models of cancer cachexia show that the administration of vitamin D to tumor-bearing animals is not able to prevent or delay both muscle wasting and adipose tissue depletion, despite increased expression of muscle vitamin D receptor. Vitamin D 88-97 vitamin D receptor Homo sapiens 244-262 28905271-1 2017 BACKGROUND: 2-Methylene-19-nor-(20S)-1alpha,25-dihydroxyvitamin D3 (DP001 or 2MD) is a novel, potent 1alpha-hydroxylated vitamin D analog that binds to the vitamin D receptor and suppresses parathyroid hormone synthesis and secretion with potential for an improved safety profile compared to existing active vitamin D analogs. Vitamin D 56-65 vitamin D receptor Homo sapiens 156-174 28905271-1 2017 BACKGROUND: 2-Methylene-19-nor-(20S)-1alpha,25-dihydroxyvitamin D3 (DP001 or 2MD) is a novel, potent 1alpha-hydroxylated vitamin D analog that binds to the vitamin D receptor and suppresses parathyroid hormone synthesis and secretion with potential for an improved safety profile compared to existing active vitamin D analogs. Vitamin D 121-130 vitamin D receptor Homo sapiens 156-174 29080642-2 2017 For the vitamin D metabolites less than 1% (0.4% for 1,25(OH)2D and 0.03% for 25(OH)D) is free, with more than 99% bound to the vitamin D binding protein (DBP) and albumin (approximately 85% and 15%, respectively). Vitamin D 8-17 GC vitamin D binding protein Homo sapiens 128-153 29220424-3 2017 Twelve SNPs involved in the vitamin D mechanistic pathways were studied [biosynthetic: rs4646536, rs10877012, rs3829251, rs1790349; activation: rs2060793, rs1993116; vitamin D-binding protein (VBP)/group-specific component (GC): rs4588, rs7041, rs2282679, rs1155563; and vitamin D receptor: rs1544410, rs10735810]. Vitamin D 28-37 GC vitamin D binding protein Homo sapiens 166-191 29220424-3 2017 Twelve SNPs involved in the vitamin D mechanistic pathways were studied [biosynthetic: rs4646536, rs10877012, rs3829251, rs1790349; activation: rs2060793, rs1993116; vitamin D-binding protein (VBP)/group-specific component (GC): rs4588, rs7041, rs2282679, rs1155563; and vitamin D receptor: rs1544410, rs10735810]. Vitamin D 28-37 GC vitamin D binding protein Homo sapiens 193-196 29220424-3 2017 Twelve SNPs involved in the vitamin D mechanistic pathways were studied [biosynthetic: rs4646536, rs10877012, rs3829251, rs1790349; activation: rs2060793, rs1993116; vitamin D-binding protein (VBP)/group-specific component (GC): rs4588, rs7041, rs2282679, rs1155563; and vitamin D receptor: rs1544410, rs10735810]. Vitamin D 28-37 vitamin D receptor Homo sapiens 271-289 28803336-10 2017 This study is the first to achieve lung-specific overexpression of VDR in TG mice: an interesting animal model useful for studying the relation between airway cell inflammation and vitamin D signaling. Vitamin D 181-190 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 67-70 28589382-3 2017 We analyzed gene and protein expression of VDR and PR and gene expression of vitamin D-inactivating 24-hyroxylase (CYP24A1) and the activating 1-alpha-hydroxylase (CYP27B1) enzymes in follicular cancer cells and the adjacent non-neoplastic thyroid tissue (NNTT). Vitamin D 77-86 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 115-122 28665452-1 2017 BACKGROUND: The metabolism of vitamin D is complex, its receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 can influence vitamin D serum levels. Vitamin D 30-39 vitamin D receptor Homo sapiens 66-69 28665452-1 2017 BACKGROUND: The metabolism of vitamin D is complex, its receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 can influence vitamin D serum levels. Vitamin D 30-39 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 117-124 28665452-1 2017 BACKGROUND: The metabolism of vitamin D is complex, its receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 can influence vitamin D serum levels. Vitamin D 139-148 vitamin D receptor Homo sapiens 66-69 28665452-1 2017 BACKGROUND: The metabolism of vitamin D is complex, its receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 can influence vitamin D serum levels. Vitamin D 139-148 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 117-124 28665452-2 2017 The aim of this study was to investigate the relationship of the polymorphisms of VDR (ApaI and BsmI), CYP27B1 and CYP24A1 with serum vitamin D levels in both forms, 25(OH)D3 (circulating form) and 1,25(OH)2D3 (active form), in colorectal cancer (CRC) patients. Vitamin D 134-143 vitamin D receptor Homo sapiens 82-85 28665452-2 2017 The aim of this study was to investigate the relationship of the polymorphisms of VDR (ApaI and BsmI), CYP27B1 and CYP24A1 with serum vitamin D levels in both forms, 25(OH)D3 (circulating form) and 1,25(OH)2D3 (active form), in colorectal cancer (CRC) patients. Vitamin D 134-143 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 115-122 28579119-5 2017 The demonstration that breast cells express CYP27B1 (which converts the precursor vitamin D metabolite 25D to the active metabolite 1,25D) and CYP24A1 (which degrades both 25D and 1,25D) provides insight into the difficulties inherent in using dietary vitamin D, sun exposure and/or serum biomarkers of vitamin D status to predict disease outcomes. Vitamin D 252-261 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 143-150 28579119-5 2017 The demonstration that breast cells express CYP27B1 (which converts the precursor vitamin D metabolite 25D to the active metabolite 1,25D) and CYP24A1 (which degrades both 25D and 1,25D) provides insight into the difficulties inherent in using dietary vitamin D, sun exposure and/or serum biomarkers of vitamin D status to predict disease outcomes. Vitamin D 252-261 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 143-150 28579120-4 2017 Vitamin D signalling occurs via the vitamin D receptor (VDR), a zinc-finger protein in the nuclear receptor superfamily. Vitamin D 0-9 vitamin D receptor Homo sapiens 36-54 28579120-4 2017 Vitamin D signalling occurs via the vitamin D receptor (VDR), a zinc-finger protein in the nuclear receptor superfamily. Vitamin D 0-9 vitamin D receptor Homo sapiens 56-59 28579120-6 2017 The transcriptional activity of vitamin D occurs via the nuclear VDR. Vitamin D 32-41 vitamin D receptor Homo sapiens 65-68 28579120-8 2017 The VDR is present in the developing and adult brain where it mediates the effects of vitamin D on brain development and function. Vitamin D 86-95 vitamin D receptor Homo sapiens 4-7 28602863-5 2017 Vitamin D receptor number decreases with aging in several organs involved in calcium metabolism and 1alpha-hydroxylase activity decreases mainly due to a decrease in renal function reducing vitamin D activation. Vitamin D 190-199 vitamin D receptor Homo sapiens 0-18 28902929-9 2017 These results indicated that vitamin D concentrations in the decidua are associated with inflammatory cytokine production, suggesting that vitamin D and VDR may play a role in the etiology of RSA. Vitamin D 29-38 vitamin D receptor Homo sapiens 153-156 28739397-1 2017 BACKGROUND: Data concerning the association of serum levels of vitamin D and metalloproteinases and vitamin D receptor gene polymorphism with coronary artery disease (CAD) is not fully demonstrated. Vitamin D 63-72 vitamin D receptor Homo sapiens 100-118 28891930-4 2017 The effects of vitamin D and interaction with the VDR may be influenced by polymorphism in the VDR gene. Vitamin D 15-24 vitamin D receptor Homo sapiens 95-98 28768705-2 2017 In CKD, vitamin D metabolism is complicated by decreased conversion of 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D by CYP27B1 and possibly decreased conversion of 25-hydroxyvitamin D to 24,25-dihydroxyvitamin D by CYP24A1. Vitamin D 8-17 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 217-224 28944088-2 2017 The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D, 1,25-dihydroxy-vitamin D [1,25(OH)2D] are mediated through binding to the vitamin D receptor (VDR). Vitamin D 83-92 vitamin D receptor Homo sapiens 168-186 28944088-2 2017 The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D, 1,25-dihydroxy-vitamin D [1,25(OH)2D] are mediated through binding to the vitamin D receptor (VDR). Vitamin D 83-92 vitamin D receptor Homo sapiens 188-191 28944088-5 2017 These growth-retarding effects of VDR knockdown occur in the presence and absence of vitamin D and are independent of whether cells were grown in bone or soft tissues. Vitamin D 85-94 vitamin D receptor Homo sapiens 34-37 28463086-0 2017 Vitamin D Counteracts an IL-23-Dependent IL-17A+IFN-gamma+ Response Driven by Urban Particulate Matter. Vitamin D 0-9 interleukin 17A Homo sapiens 41-57 28712921-1 2017 The transcription factor vitamin D receptor (VDR) is the exclusive nuclear target of the biologically active form of vitamin D (1,25(OH)2D3). Vitamin D 25-34 vitamin D receptor Homo sapiens 45-48 28712921-4 2017 Machine learning and statistical analysis as well as a comparison with the re-analyzed B cell VDR cistrome indicated a subgroup of 339 highly conserved persistent VDR sites that were suited best for describing vitamin D-triggered gene regulatory scenarios. Vitamin D 210-219 vitamin D receptor Homo sapiens 94-97 28712921-4 2017 Machine learning and statistical analysis as well as a comparison with the re-analyzed B cell VDR cistrome indicated a subgroup of 339 highly conserved persistent VDR sites that were suited best for describing vitamin D-triggered gene regulatory scenarios. Vitamin D 210-219 vitamin D receptor Homo sapiens 163-166 28712921-7 2017 The number of persistent and transient VDR sites was found to be the main discriminator for sorting these TADs into five classes carrying vitamin D target genes involved in distinct biological processes. Vitamin D 138-147 vitamin D receptor Homo sapiens 39-42 28712921-8 2017 In conclusion, specific regulation of biological processes by vitamin D depends on differences in time-dependent VDR binding. Vitamin D 62-71 vitamin D receptor Homo sapiens 113-116 28710799-4 2017 Vitamin D plays an important role in glucose homeostasis and insulin secretion through transcriptional mechanisms mediated by its receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 140-143 28710799-7 2017 The aim of this study was to evaluate the effect of hyperglycemia on VDR OGlcNAcylation and its effects on vitamin D-mediated transcription. Vitamin D 107-116 vitamin D receptor Homo sapiens 69-72 28492133-4 2017 However, because of vagaries in the measurement of VDBP in particular and the assumption of a constant affinity of VDBP for the vitamin D metabolites (which has been shown to be problematic), calculated values have proved suspect. Vitamin D 128-137 GC vitamin D binding protein Homo sapiens 115-119 28578001-1 2017 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], acts as a ligand for the vitamin D receptor (VDR), and regulates various physiological processes, including calcium and bone metabolism, cellular growth and differentiation, immunity and cardiovascular function. Vitamin D 19-28 vitamin D receptor Homo sapiens 100-118 28578001-1 2017 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], acts as a ligand for the vitamin D receptor (VDR), and regulates various physiological processes, including calcium and bone metabolism, cellular growth and differentiation, immunity and cardiovascular function. Vitamin D 19-28 vitamin D receptor Homo sapiens 120-123 28578001-4 2017 Our prior study has demonstrated that 1,25(OH)2D3 induces TRPV6 mRNA expression at lower concentrations than for induction of CYP24A1, a VDR target gene involved in vitamin D inactivation, in intestinal SW480 cells, suggesting an additional mechanism for vitamin D signaling on TRPV6 induction. Vitamin D 165-174 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 126-133 28578001-4 2017 Our prior study has demonstrated that 1,25(OH)2D3 induces TRPV6 mRNA expression at lower concentrations than for induction of CYP24A1, a VDR target gene involved in vitamin D inactivation, in intestinal SW480 cells, suggesting an additional mechanism for vitamin D signaling on TRPV6 induction. Vitamin D 165-174 vitamin D receptor Homo sapiens 137-140 28578001-9 2017 These findings indicate that p38alpha and GADD45alpha are involved in an enhanced vitamin D signaling on TRPV6 expression. Vitamin D 82-91 transient receptor potential cation channel subfamily V member 6 Homo sapiens 105-110 28636886-1 2017 The hormonal metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), binds to the vitamin D receptor (VDR) and promotes heterodimerization of VDR with a retinoid-X-receptor (RXR) to genomically regulate diverse cellular processes. Vitamin D 27-36 vitamin D receptor Homo sapiens 85-103 28636886-1 2017 The hormonal metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), binds to the vitamin D receptor (VDR) and promotes heterodimerization of VDR with a retinoid-X-receptor (RXR) to genomically regulate diverse cellular processes. Vitamin D 27-36 vitamin D receptor Homo sapiens 105-108 28636886-1 2017 The hormonal metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), binds to the vitamin D receptor (VDR) and promotes heterodimerization of VDR with a retinoid-X-receptor (RXR) to genomically regulate diverse cellular processes. Vitamin D 27-36 vitamin D receptor Homo sapiens 145-148 28636886-1 2017 The hormonal metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), binds to the vitamin D receptor (VDR) and promotes heterodimerization of VDR with a retinoid-X-receptor (RXR) to genomically regulate diverse cellular processes. Vitamin D 27-36 retinoid X receptor alpha Homo sapiens 156-175 28636886-1 2017 The hormonal metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), binds to the vitamin D receptor (VDR) and promotes heterodimerization of VDR with a retinoid-X-receptor (RXR) to genomically regulate diverse cellular processes. Vitamin D 27-36 retinoid X receptor alpha Homo sapiens 177-180 28732681-1 2017 Vitamin D binding protein (DBP) concentration is known to influence the availability and bioactivity of vitamin D metabolites but its diurnal rhythm (DR), its inter-relationships with the DRs of vitamin D metabolites and its influence on free vitamin D metabolite concentrations are not well described. Vitamin D 104-113 GC vitamin D binding protein Homo sapiens 0-25 28732681-1 2017 Vitamin D binding protein (DBP) concentration is known to influence the availability and bioactivity of vitamin D metabolites but its diurnal rhythm (DR), its inter-relationships with the DRs of vitamin D metabolites and its influence on free vitamin D metabolite concentrations are not well described. Vitamin D 195-204 GC vitamin D binding protein Homo sapiens 0-25 28732681-1 2017 Vitamin D binding protein (DBP) concentration is known to influence the availability and bioactivity of vitamin D metabolites but its diurnal rhythm (DR), its inter-relationships with the DRs of vitamin D metabolites and its influence on free vitamin D metabolite concentrations are not well described. Vitamin D 195-204 GC vitamin D binding protein Homo sapiens 0-25 28817905-0 2017 Re: CYP3A4 Induction by Rifampin: An Alternative Pathway for Vitamin D Inactivation in Patients with CYP24A1 Mutations. Vitamin D 61-70 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 101-108 28779988-2 2017 Genetic variants of the Vitamin D Binding Protein (VDBP), the main transporter of vitamin D in the bloodstream, have been shown to account for a significant variability in the levels and systemic effects of vitamin D. Vitamin D 82-91 GC vitamin D binding protein Homo sapiens 24-49 28779988-2 2017 Genetic variants of the Vitamin D Binding Protein (VDBP), the main transporter of vitamin D in the bloodstream, have been shown to account for a significant variability in the levels and systemic effects of vitamin D. Vitamin D 82-91 GC vitamin D binding protein Homo sapiens 51-55 28779988-2 2017 Genetic variants of the Vitamin D Binding Protein (VDBP), the main transporter of vitamin D in the bloodstream, have been shown to account for a significant variability in the levels and systemic effects of vitamin D. Vitamin D 207-216 GC vitamin D binding protein Homo sapiens 24-49 28779988-2 2017 Genetic variants of the Vitamin D Binding Protein (VDBP), the main transporter of vitamin D in the bloodstream, have been shown to account for a significant variability in the levels and systemic effects of vitamin D. Vitamin D 207-216 GC vitamin D binding protein Homo sapiens 51-55 28070798-5 2017 Moreover, the expression of the vitamin D receptor (VDR) in these cells suggests a local action of vitamin D in the immune response. Vitamin D 32-41 vitamin D receptor Homo sapiens 52-55 28830368-1 2017 BACKGROUND: There is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population. Vitamin D 68-77 vitamin D receptor Homo sapiens 203-206 28830368-1 2017 BACKGROUND: There is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population. Vitamin D 68-77 vitamin D receptor Homo sapiens 208-226 28989587-9 2017 Also Vitamin D deficient patients had higher serum ALP levels. Vitamin D 5-14 ATHS Homo sapiens 51-54 28304097-5 2017 We employed an extended 20-min run time on LC-MS/MS to study serum vitamin D metabolites in patients with IIH due to mutations of CYP24A1 or SLC34A1; in unaffected heterozygotes and dialysis patients; in patients with vitamin D deficiency; as well as in normal subjects exhibiting a broad range of 25-OH-D levels. Vitamin D 67-76 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 130-137 28670298-5 2017 Vitamin D treatment was also accompanied by 100-fold to 700-fold increases in vitamin D receptor expression during the treatment period (P < 0.001). Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 78-96 28465245-8 2017 High levels of VDR in human gastric cancer tissues and cancer cell lines implicated that vitamin D could display more potent pharmacological action against malignant cells. Vitamin D 89-98 vitamin D receptor Homo sapiens 15-18 28617856-0 2017 The associations between VDR BsmI polymorphisms and risk of vitamin D deficiency, obesity and insulin resistance in adolescents residing in a tropical country. Vitamin D 60-69 vitamin D receptor Homo sapiens 25-28 28617856-2 2017 The rs1544410 or BsmI single nucleotide polymorphism (SNP) in the intronic region of the VDR gene has been previously associated with vitamin D levels, obesity and insulin resistance. Vitamin D 134-143 vitamin D receptor Homo sapiens 89-92 28177161-0 2017 VDR in Osteoblast-Lineage Cells Primarily Mediates Vitamin D Treatment-Induced Increase in Bone Mass by Suppressing Bone Resorption. Vitamin D 51-60 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 0-3 28385183-3 2017 Due the important immune-modulating properties of Vitamin D, Vitamin D receptor (VDR) gene polymorphisms - which interfere with the actions of Vitamin D- could be related to increased risk of MS. METHODS: We studied 120 patients fulfilling the McDonald criteria for MS (81 females and 39 males) and 180 healthy unrelated controls, nested in a case-Control study, and were recruited from the National Institute of Neurology and Neurosurgery, Manuel Velasco Suarez in Mexico City. Vitamin D 50-59 vitamin D receptor Homo sapiens 81-84 28385183-3 2017 Due the important immune-modulating properties of Vitamin D, Vitamin D receptor (VDR) gene polymorphisms - which interfere with the actions of Vitamin D- could be related to increased risk of MS. METHODS: We studied 120 patients fulfilling the McDonald criteria for MS (81 females and 39 males) and 180 healthy unrelated controls, nested in a case-Control study, and were recruited from the National Institute of Neurology and Neurosurgery, Manuel Velasco Suarez in Mexico City. Vitamin D 61-70 vitamin D receptor Homo sapiens 81-84 27715403-5 2017 Calcitriol, the active form of vitamin D, has been shown to decrease STAT1 and STAT3 phosphorylation in cancer cell lines and autoimmune disease mouse models. Vitamin D 31-40 signal transducer and activator of transcription 1 Mus musculus 69-74 28009432-1 2017 INTRODUCTION: Vitamin D receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 involved in the production and inactivation of vitamin D can influence vitamin D and the susceptibility to colorectal cancer (CRC). Vitamin D 140-149 vitamin D receptor Homo sapiens 14-32 28009432-1 2017 INTRODUCTION: Vitamin D receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 involved in the production and inactivation of vitamin D can influence vitamin D and the susceptibility to colorectal cancer (CRC). Vitamin D 140-149 vitamin D receptor Homo sapiens 34-37 28009432-1 2017 INTRODUCTION: Vitamin D receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 involved in the production and inactivation of vitamin D can influence vitamin D and the susceptibility to colorectal cancer (CRC). Vitamin D 140-149 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 85-92 28009432-1 2017 INTRODUCTION: Vitamin D receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 involved in the production and inactivation of vitamin D can influence vitamin D and the susceptibility to colorectal cancer (CRC). Vitamin D 164-173 vitamin D receptor Homo sapiens 14-32 28009432-1 2017 INTRODUCTION: Vitamin D receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 involved in the production and inactivation of vitamin D can influence vitamin D and the susceptibility to colorectal cancer (CRC). Vitamin D 164-173 vitamin D receptor Homo sapiens 34-37 28009432-1 2017 INTRODUCTION: Vitamin D receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 involved in the production and inactivation of vitamin D can influence vitamin D and the susceptibility to colorectal cancer (CRC). Vitamin D 164-173 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 85-92 28464004-12 2017 In fully adjusted models, vitamin D associations with abnormal biomarker levels persisted for IL-6 levels and CX3CR1+ and CCR2+ phenotypes. Vitamin D 26-35 C-X3-C motif chemokine receptor 1 Homo sapiens 110-116 28431765-4 2017 The immune-modulating effects appear to be mediated by vitamin D interaction with the vitamin D receptor (VDR) that has transcriptional effects and is expressed on various cell types, especially those of the immune system. Vitamin D 55-64 vitamin D receptor Homo sapiens 86-104 28431765-4 2017 The immune-modulating effects appear to be mediated by vitamin D interaction with the vitamin D receptor (VDR) that has transcriptional effects and is expressed on various cell types, especially those of the immune system. Vitamin D 55-64 vitamin D receptor Homo sapiens 106-109 28095044-2 2017 Vitamin D3 undergoes conversion through a multitude of enzymatic reactions described within the paper, and vitamin D levels are dependent on many factors including the vitamin D binding protein (DBP). Vitamin D 107-116 GC vitamin D binding protein Homo sapiens 168-193 28008175-0 2017 CLL-cell-mediated MDSC induction by exosomal miR-155 transfer is disrupted by vitamin D. Vitamin D 78-87 microRNA 155 Homo sapiens 45-52 28423519-5 2017 Vitamin D treatment resulted in VDR overexpression and myogenin down-regulation. Vitamin D 0-9 myogenin Rattus norvegicus 55-63 28325820-1 2017 Vitamin D receptor represses basal autophagy in breast tissue, which is derepressed by vitamin D, slowing cancer progression. Vitamin D 87-96 vitamin D receptor Homo sapiens 0-18 28222207-3 2017 In this study, we aimed to evaluate the impact of the dialysis membrane on 25(OH)D, albumin (Alb) and vitamin D-binding protein (VDBP), the major players of vitamin D transport and storage. Vitamin D 102-111 GC vitamin D binding protein Homo sapiens 129-133 28300755-6 2017 Vitamin D not only inhibited the expression of Runx2 target genes MMP1, MMP28 and kallikrein related peptidase-7 (KLK7), but also migration and invasion of 143B OS cells. Vitamin D 0-9 matrix metallopeptidase 28 Homo sapiens 72-77 28300755-6 2017 Vitamin D not only inhibited the expression of Runx2 target genes MMP1, MMP28 and kallikrein related peptidase-7 (KLK7), but also migration and invasion of 143B OS cells. Vitamin D 0-9 kallikrein related peptidase 4 Homo sapiens 82-92 28253304-13 2017 Of the vitamin D-related genes, only CYP24A1 gene rs6013897 was associated with total hip BMD, but the association was weak and needs confirmation in other studies. Vitamin D 7-16 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 37-44 28382877-4 2017 In all, eleven SNP in four vitamin D-related genes: Cytochrome P450 subfamily IIR1 (CYP2R1); 7-dehydrocholesterol reductase/nicotinamide adenine dinucleotide synthetase-1(DHCR7/NADSYN1); group-specific complement (GC); and vitamin D receptor were genotyped. Vitamin D 27-36 7-dehydrocholesterol reductase Homo sapiens 124-176 28382877-4 2017 In all, eleven SNP in four vitamin D-related genes: Cytochrome P450 subfamily IIR1 (CYP2R1); 7-dehydrocholesterol reductase/nicotinamide adenine dinucleotide synthetase-1(DHCR7/NADSYN1); group-specific complement (GC); and vitamin D receptor were genotyped. Vitamin D 27-36 NAD synthetase 1 Homo sapiens 177-184 28063327-10 2017 CONCLUSION: Newly diagnosed LN patients demonstrated elevated FGF23 levels that were positively correlated to urinary MCP1, independently of vitamin D levels and kidney function. Vitamin D 141-150 fibroblast growth factor 23 Homo sapiens 62-67 27989685-1 2017 BACKGROUND: Calcitriol, the bioactive metabolite of vitamin D, exerts its effects through interaction with the nuclear vitamin D receptor (VDR) to induce genomic responses. Vitamin D 52-61 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 119-137 27989685-1 2017 BACKGROUND: Calcitriol, the bioactive metabolite of vitamin D, exerts its effects through interaction with the nuclear vitamin D receptor (VDR) to induce genomic responses. Vitamin D 52-61 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 139-142 27423437-7 2017 The aim of this study was to evaluate the effect of vitamin D supplementation on FoxP3 expression and IL-17A-producing T cells, through FoxP3+/IL-17A ratio. Vitamin D 52-61 interleukin 17A Homo sapiens 102-108 27423437-7 2017 The aim of this study was to evaluate the effect of vitamin D supplementation on FoxP3 expression and IL-17A-producing T cells, through FoxP3+/IL-17A ratio. Vitamin D 52-61 interleukin 17A Homo sapiens 143-149 27423437-13 2017 The FoxP3+/IL-17A ratio in SLE patients after 6 months of vitamin D supplementation was higher than that in the baseline (p < 0.001). Vitamin D 58-67 interleukin 17A Homo sapiens 11-17 27618536-14 2017 Vitamin D may be dysregulated at multiple levels, with decreased transcription of the metabolic gene CYP27B1 and increased transcription of the catabolic gene CYP24A1 observed. Vitamin D 0-9 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 159-166 27732326-6 2017 Results: Two single nucleotide polymorphisms (SNPs), rs3755967 (GC) and rs11603330 (DHCR7), were associated with higher risk of low vitamin D status [odds ratio (95% confidence interval) per minor allele, 1.27 (1.18 to 1.36) and 1.16 (1.08 to 1.25), respectively]. Vitamin D 132-141 7-dehydrocholesterol reductase Homo sapiens 84-89 28003380-2 2017 The active form of vitamin D [1,25(OH)2D] regulates B cells in vitro and mice without the vitamin D receptor (VDR knockout [KO]) have high serum IgE. Vitamin D 19-28 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 110-113 28003380-10 2017 Through the VDR, vitamin D is an environmental factor that helps to maintain low serum IgE responses. Vitamin D 17-26 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 12-15 28110703-1 2017 Fibroblast growth factor 23 (FGF23), a hormonal regulator of phosphate and vitamin D metabolism produced primarily in bone by osteocytes and mature osteoblasts, is now known to have growth factor activity for many prostate cancers. Vitamin D 75-84 fibroblast growth factor 23 Homo sapiens 0-27 28110703-1 2017 Fibroblast growth factor 23 (FGF23), a hormonal regulator of phosphate and vitamin D metabolism produced primarily in bone by osteocytes and mature osteoblasts, is now known to have growth factor activity for many prostate cancers. Vitamin D 75-84 fibroblast growth factor 23 Homo sapiens 29-34 28065683-8 2017 DM1 and DM2 patients display a high frequency of skin abnormalities, the most common of which correlate with genotype severity and serum vitamin D levels. Vitamin D 137-146 DM1 protein kinase Homo sapiens 0-3 27905210-1 2017 In vitro, mono- and polyunsaturated fatty acids (FAs) may decrease the binding affinity of vitamin D metabolites for vitamin D-binding protein, which in turn may influence their bioavailability. Vitamin D 91-100 GC vitamin D binding protein Homo sapiens 117-142 27896829-2 2017 The role of vitamin D in autoimmune diseases has increased significantly in the recent past from its functions in calcium and phosphate homoeostasis, and it is now involved in the regulations and proliferations of Th1 and Th17 lymphocyte. Vitamin D 12-21 negative elongation factor complex member C/D Homo sapiens 214-217 27896829-8 2017 Vitamin D supplementation assists in autoimmune disorders by making qualitative and quantitative changes in the immune system (downregulation of Th1 and upregulations of Th2 cells). Vitamin D 0-9 negative elongation factor complex member C/D Homo sapiens 145-148 28025137-1 2017 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1alpha,25D3), plays an important role in the maintenance of calcium (Ca) homeostasis, bone formation, and cell proliferation and differentiation via nuclear vitamin D receptor (VDR). Vitamin D 19-28 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 218-236 28025137-1 2017 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1alpha,25D3), plays an important role in the maintenance of calcium (Ca) homeostasis, bone formation, and cell proliferation and differentiation via nuclear vitamin D receptor (VDR). Vitamin D 19-28 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 238-241 28293436-2 2017 Vitamin D-binding protein transports vitamin D and influences the metabolism of this key hormone but it also has additional immunomodulatory and actin-clearing properties. Vitamin D 37-46 GC vitamin D binding protein Homo sapiens 0-25 28293436-7 2017 The results showed significantly reduced levels of placental vitamin D-binding protein (control versus FGR, p < 0.05, Student"s t-test) that were strongly associated with idiopathic fetal growth restriction (p < 0.01, Kruskal-Wallis), whereas levels of vitamin D-binding protein were not associated with placental 25(OH) vitamin D stores (p = 0.295, Pearson"s correlation). Vitamin D 61-70 GC vitamin D binding protein Homo sapiens 259-284 27060335-5 2017 The inactivation of vitamin D is principally initiated by its 23- and 24-hydroxylation by CYP24A1. Vitamin D 20-29 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 90-97 27520299-6 2017 Here we provide evidence that phosphorylation plays a role in controlling DHCR7 activity, which may provide a means to divert flux from cholesterol synthesis to vitamin D production. Vitamin D 161-170 7-dehydrocholesterol reductase Homo sapiens 74-79 27520299-9 2017 Thus, we demonstrate that phosphorylation modulates DHCR7 activity in cells, and contributes to the overall synthesis of cholesterol, and probably vitamin D. Vitamin D 147-156 7-dehydrocholesterol reductase Homo sapiens 52-57 27520301-6 2017 Several functions of unliganded nVDR were discovered by studying human samples from patients having hereditary vitamin D resistant rickets, transgenic mice overexpressing the VDR and VDR knockout mice. Vitamin D 111-120 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 33-36 28787727-5 2017 Using candidate gene approach, obesity- (insulin-like growth factor 2 (IGF2), proopiomelanocortin (POMC)) and vitamin D metabolism-related genes (1-alfa-hydroxylase (CYP27B1), VDR) regulated by DNA methylation were selected. Vitamin D 110-119 vitamin D receptor Homo sapiens 176-179 30695614-0 2017 [The study of the association between rs2228570 polymorphism of VDR gene and vitamin D blood serum concentration in the inhabitants of the Russian Arctic]. Vitamin D 77-86 vitamin D receptor Homo sapiens 64-67 30695614-2 2017 The aim of this study was to evaluate the possible association between VDR FokI polymorphism and vitamin D sufficiency in the population of the Yamal-Nenets Autonomous District of the Russian Federation. Vitamin D 97-106 vitamin D receptor Homo sapiens 71-74 30695614-12 2017 Thus, the association between C allele presence of rs2228570 polymorphism of VDR gene and a deficiency of vitamin D (reduced levels of 25 (OH)D in blood serum) has been revealed. Vitamin D 106-115 vitamin D receptor Homo sapiens 77-80 28058015-8 2016 RESULTS: The active form of vitamin D, 1,25D3, showed enhanced VDR-mediated Atg16L1 mRNA expression, membranous Atg16L1 protein expression leading to enhanced autophagic LC3II protein expression and LC3 punctae in Salmonella-infected Caco-2 cells which was counteracted by Atg16L1 and VDR siRNA, but Atg16L1 mediated suppression of IL-1beta expression. Vitamin D 28-37 vitamin D receptor Homo sapiens 63-66 27941640-8 2016 Among the factors increasing plasma FGF23 concentration, active vitamin D analogues play a significant role. Vitamin D 64-73 fibroblast growth factor 23 Homo sapiens 36-41 27768599-1 2016 Vitamin D is implicated in the etiology of cancers of the gastrointestinal tract, usually characterized by alteration in the APC/beta-catenin/TCF tumor suppressor pathway. Vitamin D 0-9 catenin (cadherin associated protein), beta 1 Mus musculus 129-141 27769995-0 2016 Parental vitamin D deficiency during pregnancy is associated with increased blood pressure in offspring via Panx1 hypermethylation. Vitamin D 9-18 Pannexin 1 Rattus norvegicus 108-113 27435264-9 2016 In conclusion, MDD inactivates vitamin D signaling via both disruption of VDR-PGC1alpha interaction and sequestration of nuclear VDR attributable to HSP90 overexpression. Vitamin D 31-40 vitamin D receptor Homo sapiens 74-77 27435264-9 2016 In conclusion, MDD inactivates vitamin D signaling via both disruption of VDR-PGC1alpha interaction and sequestration of nuclear VDR attributable to HSP90 overexpression. Vitamin D 31-40 vitamin D receptor Homo sapiens 129-132 27106018-9 2016 CONCLUSIONS: We show for the first time that progestins and vitamin D synergistically reduce cell viability and induce apoptosis in ovarian cells and that progestins PR-dependently inhibit CAL-induced CYP24A1, thus extending CAL activity. Vitamin D 60-69 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 201-208 26943611-2 2016 FGF23 was originally shown to play a central role in phosphate (Pi) and vitamin D metabolism, and a number of diseases associated with dysregulated Pi metabolism have been attributed to abnormal FGF23 signaling activities. Vitamin D 72-81 fibroblast growth factor 23 Homo sapiens 0-5 26943611-3 2016 The discovery of Klotho as a co-receptor for FGF23 signaling has also accelerated understanding on the molecular mechanisms underlying Pi and vitamin D metabolism. Vitamin D 142-151 klotho Homo sapiens 17-23 26943611-3 2016 The discovery of Klotho as a co-receptor for FGF23 signaling has also accelerated understanding on the molecular mechanisms underlying Pi and vitamin D metabolism. Vitamin D 142-151 fibroblast growth factor 23 Homo sapiens 45-50 27573000-5 2016 Other proteins modulated by vitamin D play important roles in calcium regulation e.g., calbindin 1 (CALB1) and transient receptor potential cation channel 6 (TRPV6). Vitamin D 28-37 transient receptor potential cation channel subfamily V member 6 Homo sapiens 158-163 27215557-3 2016 Klotho and FGF23 are crucial components for the regulation of vitamin D metabolism and subsequently blood phosphate levels. Vitamin D 62-71 klotho Homo sapiens 0-6 27215557-3 2016 Klotho and FGF23 are crucial components for the regulation of vitamin D metabolism and subsequently blood phosphate levels. Vitamin D 62-71 fibroblast growth factor 23 Homo sapiens 11-16 26513595-3 2016 An elevated expression of the CYP24A1 leads to the deficiency of vitamin D and resistance to vitamin D therapy. Vitamin D 65-74 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 30-37 26513595-3 2016 An elevated expression of the CYP24A1 leads to the deficiency of vitamin D and resistance to vitamin D therapy. Vitamin D 93-102 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 30-37 27105398-17 2016 CYP24A1 deficiency should be considered in patients with unexplained vitamin D-mediated hypercalcemia. Vitamin D 69-78 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 0-7 26869016-2 2016 The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D receptor binding protein (VDBP) may be influenced by polymorphisms in the VDR and VDBP genes. Vitamin D 15-24 vitamin D receptor Homo sapiens 61-79 26869016-2 2016 The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D receptor binding protein (VDBP) may be influenced by polymorphisms in the VDR and VDBP genes. Vitamin D 15-24 vitamin D receptor Homo sapiens 81-84 26869016-2 2016 The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D receptor binding protein (VDBP) may be influenced by polymorphisms in the VDR and VDBP genes. Vitamin D 15-24 GC vitamin D binding protein Homo sapiens 90-124 26869016-2 2016 The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D receptor binding protein (VDBP) may be influenced by polymorphisms in the VDR and VDBP genes. Vitamin D 15-24 GC vitamin D binding protein Homo sapiens 126-130 26869016-2 2016 The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D receptor binding protein (VDBP) may be influenced by polymorphisms in the VDR and VDBP genes. Vitamin D 15-24 vitamin D receptor Homo sapiens 174-177 26869016-2 2016 The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D receptor binding protein (VDBP) may be influenced by polymorphisms in the VDR and VDBP genes. Vitamin D 15-24 GC vitamin D binding protein Homo sapiens 182-186 27686292-1 2016 OBJECTIVE: To compare the pattern of Vitamin D receptor (VDR) polymorphisms (Apa I and Fok I) in Type I Diabetes mellitus (T1DM) as cases vs healthy population as control and to investigate the association of VDR polymorphism with vitamin D levels in cases and controls. Vitamin D 231-240 vitamin D receptor Homo sapiens 37-55 27154413-12 2016 Thus, 1,25(OH)2D down-regulation of the glutamine transporter, SLC1A5, may facilitate vitamin D prevention of breast cancer. Vitamin D 86-95 solute carrier family 1 member 5 Homo sapiens 63-69 27174721-1 2016 BACKGROUND: Vitamin D is a chemopreventive agent that acts against colorectal carcinogenesis in vivo and in vitro through vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 122-140 27174721-1 2016 BACKGROUND: Vitamin D is a chemopreventive agent that acts against colorectal carcinogenesis in vivo and in vitro through vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 142-145 27475231-1 2016 Vitamin D supplementation in humans should be accompanied by calcium administration to avoid bone demineralization through vitamin D receptor signaling. Vitamin D 0-9 vitamin D receptor Homo sapiens 123-141 27450565-3 2016 To directly examine this signaling relationship, in the present study we have over-expressed the vitamin D receptor (VDR) in neuroblastoma SH-SY5Y cells in order to examine the mechanisms by which the active vitamin D hormone, 1,25(OH)2D3, via its receptor VDR, affects DA production and turnover. Vitamin D 97-106 vitamin D receptor Homo sapiens 117-120 27401223-5 2016 We describe the functional environment around DHCR7, including pharmacological DHCR7 inhibitors and cholesterol and vitamin D synthesis. Vitamin D 116-125 7-dehydrocholesterol reductase Homo sapiens 46-51 27685656-8 2016 Furthermore, expression changes of Vitamin D metabolism genes in VDR-/-mice were detected. Vitamin D 35-44 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 65-68 27669215-13 2016 In summary, the results suggested that the lower the distribution of vitamin D concentration, the more the genetic variations in CYP24A1, VDR and GC genes may be associated with NSCLC risk. Vitamin D 69-78 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 129-136 27669215-13 2016 In summary, the results suggested that the lower the distribution of vitamin D concentration, the more the genetic variations in CYP24A1, VDR and GC genes may be associated with NSCLC risk. Vitamin D 69-78 vitamin D receptor Homo sapiens 138-141 27766277-3 2016 The effect of vitamin D on prostate epithelial cell proliferation and differentiation is well documented and genistein may augment this affect through inhibition of the CYP24 enzyme, which is responsible for intracellular vitamin D metabolism. Vitamin D 222-231 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 169-174 27632366-1 2016 The aim of this study was to determine the relative abundance and relationship of vitamin D responsive and calcium transporting transcripts (TRPV5, TRPV6, calD9k, calD28k, PMCA, NCX1, CYP27B1, CYP24A1, and VDR) in ovine, canine and, equine kidney using quantitative real-time PCR (RT-qPCR), and then perform a comparison between the three species. Vitamin D 82-91 cytochrome P450 family 24 subfamily A member 1 Canis lupus familiaris 193-200 27703587-2 2016 Vitamin D plays an important role in immune system through Vitamin D Receptors (VDR), which are transcription factors located abundantly in the body. Vitamin D 0-9 vitamin D receptor Homo sapiens 59-78 27703587-2 2016 Vitamin D plays an important role in immune system through Vitamin D Receptors (VDR), which are transcription factors located abundantly in the body. Vitamin D 0-9 vitamin D receptor Homo sapiens 80-83 27178987-1 2016 Fibroblast growth factor-23 (FGF23) is a bone-derived hormone known to suppress phosphate reabsorption and vitamin D hormone production in the kidney. Vitamin D 107-116 fibroblast growth factor 23 Homo sapiens 0-27 27178987-1 2016 Fibroblast growth factor-23 (FGF23) is a bone-derived hormone known to suppress phosphate reabsorption and vitamin D hormone production in the kidney. Vitamin D 107-116 fibroblast growth factor 23 Homo sapiens 29-34 27595605-1 2016 BACKGROUND: The vitamin D receptor (VDR) mediates the immunological function of vitamin D3, which activates macrophages, and vitamin D deficiency has been linked to tuberculosis risk. Vitamin D 16-25 vitamin D receptor Homo sapiens 36-39 27595605-2 2016 Single nucleotide polymorphisms (SNPs) in VDR may influence the function of vitamin D and susceptibility to tuberculosis. Vitamin D 76-85 vitamin D receptor Homo sapiens 42-45 28497083-1 2017 Introduction: The level of fibroblast growth factor 23 (FGF23) may be considered as a prognostic factor for assessing renal function in regulating components of phosphate and vitamin D hemostasis. Vitamin D 175-184 fibroblast growth factor 23 Homo sapiens 27-54 28497083-1 2017 Introduction: The level of fibroblast growth factor 23 (FGF23) may be considered as a prognostic factor for assessing renal function in regulating components of phosphate and vitamin D hemostasis. Vitamin D 175-184 fibroblast growth factor 23 Homo sapiens 56-61 27721584-1 2016 BACKGROUND: The klotho (Klt)-fibroblast growth factor-23 (FGF-23)-vitamin D axis is the main component of calcium (Ca) and phosphorus (P) metabolisms; on the contrary, it is also secreted from the choroid plexus (CP). Vitamin D 66-75 klotho Homo sapiens 16-22 27721584-1 2016 BACKGROUND: The klotho (Klt)-fibroblast growth factor-23 (FGF-23)-vitamin D axis is the main component of calcium (Ca) and phosphorus (P) metabolisms; on the contrary, it is also secreted from the choroid plexus (CP). Vitamin D 66-75 fibroblast growth factor 23 Homo sapiens 29-56 27721584-1 2016 BACKGROUND: The klotho (Klt)-fibroblast growth factor-23 (FGF-23)-vitamin D axis is the main component of calcium (Ca) and phosphorus (P) metabolisms; on the contrary, it is also secreted from the choroid plexus (CP). Vitamin D 66-75 fibroblast growth factor 23 Homo sapiens 58-64 27222384-7 2016 Vitamin D receptor gene silencing blocked this synergistic effect of vitamin D and TGFbeta1 on both collagen production and myofibroblast differentiation. Vitamin D 69-78 vitamin D receptor Homo sapiens 0-18 27217488-3 2016 Given the importance of the brain in controlling both glucose levels and body weight, we hypothesized that activation of central VDR links vitamin D to the regulation of glucose and energy homeostasis. Vitamin D 139-148 vitamin D receptor Homo sapiens 129-132 27217488-4 2016 Indeed, we found that small doses of active vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25D3) (calcitriol), into the third ventricle of the brain improved glucose tolerance and markedly increased hepatic insulin sensitivity, an effect that is dependent upon VDR within the paraventricular nucleus of the hypothalamus. Vitamin D 44-53 vitamin D receptor Homo sapiens 258-261 27269178-0 2016 Vitamin D status and its modulatory effect on interferon gamma and interleukin-10 production by peripheral blood mononuclear cells in culture. Vitamin D 0-9 interleukin 10 Homo sapiens 67-81 27269178-7 2016 In culture, vitamin D inhibited IFN-gamma production and increased IL-10 production by PBMCs. Vitamin D 12-21 interleukin 10 Homo sapiens 67-72 27269178-9 2016 CONCLUSIONS: This study demonstrates that vitamin D modulates IFN-gamma and IL-10 production and provides a rationale for evaluating vitamin D as an immunomodulatory agent. Vitamin D 42-51 interleukin 10 Homo sapiens 76-81 27345382-12 2016 Further investigations of the VDR and its relationship with PD are required to identify the role of vitamin D in the pathogenesis of PD. Vitamin D 100-109 vitamin D receptor Homo sapiens 30-33 27495287-8 2016 RESULTS: After 6 weeks of oral sodium bicarbonate, the median FGF23 increased significantly from 150.9 RU/mL (IQR 107.7-267.43) to 191.4 RU/mL (IQR 132.6-316.9) (p = 0.048) and this persisted after excluding participants who received activated vitamin D. Vitamin D 244-253 fibroblast growth factor 23 Homo sapiens 62-67 27579147-7 2016 Bioinformatic analysis revealed multiple candidate genes for both PTH and vitamin D, including CUBN, MGAT3, and NFKBIA. Vitamin D 74-83 cubilin Homo sapiens 95-99 27536155-1 2016 INTRODUCTION: Since there is evidence of the action of vitamin D as a modulator of insulin release and atherosclerosis, it may well be that the vitamin D receptor polymorphisms are associated with diabetes and its chronic complications. Vitamin D 55-64 vitamin D receptor Homo sapiens 144-162 27255724-5 2016 Furthermore, we determined whether vitamin D deficiency accelerates CAD progression by increasing KPNA4 and nuclear NF-kappaB levels in EAT. Vitamin D 35-44 karyopherin alpha 4 (importin alpha 3) Sus scrofa 98-103 27255724-12 2016 Vitamin D deficiency caused extensive CAD progression and advanced atherosclerotic plaques, which are linked to increased KPNA4 and nuclear NF-kappaB levels in the EAT. Vitamin D 0-9 karyopherin alpha 4 (importin alpha 3) Sus scrofa 122-127 27255724-14 2016 Vitamin D deficiency accelerates CAD progression at least, in part, through enhanced chronic inflammation of EAT by upregulation of KPNA4, which enhances NF-kappaB activation. Vitamin D 0-9 karyopherin alpha 4 (importin alpha 3) Sus scrofa 132-137 27215149-1 2016 INTRODUCTION: Fibroblast growth factor 23 (FGF23) is a key regulator in phosphate and vitamin D metabolism When measured with c-terminal assay, it has been shown to be increased following burn. Vitamin D 86-95 fibroblast growth factor 23 Homo sapiens 14-41 27215149-1 2016 INTRODUCTION: Fibroblast growth factor 23 (FGF23) is a key regulator in phosphate and vitamin D metabolism When measured with c-terminal assay, it has been shown to be increased following burn. Vitamin D 86-95 fibroblast growth factor 23 Homo sapiens 43-48 28164608-1 2016 BACKGROUND: The actions of Vitamin D in different tissues, including breast tissue, are mediated by vitamin D receptor (VDR). Vitamin D 27-36 vitamin D receptor Homo sapiens 100-118 28164608-1 2016 BACKGROUND: The actions of Vitamin D in different tissues, including breast tissue, are mediated by vitamin D receptor (VDR). Vitamin D 27-36 vitamin D receptor Homo sapiens 120-123 28164608-2 2016 Vitamin D has antitumor functions in the body; any changes in VDR expression can therefore affect the anticancer activities of Vitamin D. Vitamin D 127-136 vitamin D receptor Homo sapiens 62-65 27125758-0 2016 Relationship between cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects: Cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects. Vitamin D 46-55 vitamin D receptor Homo sapiens 92-95 27125758-0 2016 Relationship between cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects: Cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects. Vitamin D 169-178 vitamin D receptor Homo sapiens 92-95 27125758-1 2016 This study aimed to evaluate the relationship between the cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects. Vitamin D 83-92 vitamin D receptor Homo sapiens 129-132 32699567-3 2016 In this study, we characterize the effects of vitamin D-deficiency and sufficiency on the cutaneous expression of TREM-1, TREM-2, VDR, HMGB1, and RAGE. Vitamin D 46-55 triggering receptor expressed on myeloid cells 1 Sus scrofa 114-120 32699567-6 2016 In vitamin D-sufficient animals, keratinocytes exhibited elevated levels of TREM-1, TREM-2. Vitamin D 3-12 triggering receptor expressed on myeloid cells 1 Sus scrofa 76-82 27358421-1 2016 BACKGROUND: The biological actions of vitamin D are mediated through the vitamin D receptor (VDR). Vitamin D 38-47 vitamin D receptor Homo sapiens 73-91 27358421-1 2016 BACKGROUND: The biological actions of vitamin D are mediated through the vitamin D receptor (VDR). Vitamin D 38-47 vitamin D receptor Homo sapiens 93-96 27785354-3 2016 The functional activity of vitamin D is dependent on the genotype of the vitamin D receptor (VDR) polymorphic genes. Vitamin D 27-36 vitamin D receptor Homo sapiens 73-91 27785354-3 2016 The functional activity of vitamin D is dependent on the genotype of the vitamin D receptor (VDR) polymorphic genes. Vitamin D 27-36 vitamin D receptor Homo sapiens 93-96 27471592-2 2016 The regulation of transcellular calcium transport by 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3, the active form of vitamin D) has been confirmed in humans and rodents, and regulators, including vitamin D receptor (VDR), calcium binding protein D9k (calbindin-D9k), plasma membrane Ca(2+)-ATPase 1b (PMCA1b), PMAC2b and Orai1, are involved in this process. Vitamin D 67-76 vitamin D receptor Homo sapiens 211-214 27471592-2 2016 The regulation of transcellular calcium transport by 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3, the active form of vitamin D) has been confirmed in humans and rodents, and regulators, including vitamin D receptor (VDR), calcium binding protein D9k (calbindin-D9k), plasma membrane Ca(2+)-ATPase 1b (PMCA1b), PMAC2b and Orai1, are involved in this process. Vitamin D 67-76 ORAI calcium release-activated calcium modulator 1 Homo sapiens 316-321 27456065-0 2016 Vitamin D Deficiency Promotes Liver Tumor Growth in Transforming Growth Factor-beta/Smad3-Deficient Mice Through Wnt and Toll-like Receptor 7 Pathway Modulation. Vitamin D 0-9 toll-like receptor 7 Mus musculus 121-141 27294600-1 2016 To develop strong vitamin D receptor (VDR) antagonists and reveal their antagonistic mechanism, we designed and synthesized vitamin D analogues with bulky side chains based on the "active antagonist" concept in which antagonist prevents helix 12 (H12) folding. Vitamin D 18-27 vitamin D receptor Homo sapiens 38-41 27327272-0 2016 Profiling of Vitamin D Metabolic Intermediates toward VDR Using Novel Stable Gene Reporter Cell Lines IZ-VDRE and IZ-CYP24. Vitamin D 13-22 vitamin D receptor Homo sapiens 54-57 27327272-0 2016 Profiling of Vitamin D Metabolic Intermediates toward VDR Using Novel Stable Gene Reporter Cell Lines IZ-VDRE and IZ-CYP24. Vitamin D 13-22 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 117-122 27327272-1 2016 Variety of xenobiotics, including therapeutically used vitamin D analogues or environmental and alimentary endocrine disruptors, may interfere with vitamin D receptor (VDR) signaling, with serious physiological or pathophysiological consequences. Vitamin D 55-64 vitamin D receptor Homo sapiens 148-166 27327272-1 2016 Variety of xenobiotics, including therapeutically used vitamin D analogues or environmental and alimentary endocrine disruptors, may interfere with vitamin D receptor (VDR) signaling, with serious physiological or pathophysiological consequences. Vitamin D 55-64 vitamin D receptor Homo sapiens 168-171 27392908-1 2016 BACKGROUND: Vitamin D and vitamin D dependent antimicrobial peptides such as Cathelicidin (LL-37) and beta-defensin 2 have an important role in innate and adaptative immunity, but their role in pleural effusions has not been studied before. Vitamin D 12-21 defensin beta 4B Homo sapiens 102-117 27392908-1 2016 BACKGROUND: Vitamin D and vitamin D dependent antimicrobial peptides such as Cathelicidin (LL-37) and beta-defensin 2 have an important role in innate and adaptative immunity, but their role in pleural effusions has not been studied before. Vitamin D 26-35 defensin beta 4B Homo sapiens 102-117 27337485-6 2016 Prominent here is the vitamin D-dependent antimicrobial pathway common to human macrophages activated by innate and acquired immune responses, mediated by antimicrobial peptides, e.g., cathelicidin, through an interleukin-15- and interleukin-32-dependent common pathway that is necessary for macrophage killing of M. tuberculosis in vitro. Vitamin D 22-31 interleukin 15 Homo sapiens 210-225 27139837-6 2016 Among vitamin D pathway gene polymorphisms, VDR FokI T>C was a factor associated with the presence of MC in the study population (P=0.011): related to C allele carriers (TT vs. TC/CC), we obtained a P-value of 0.003. Vitamin D 6-15 vitamin D receptor Homo sapiens 44-47 27403909-2 2016 FGF23 together with its cofactor, alpha-Klotho protein, plays a pivotal role in calcium-phosphorus metabolism in patients with CKD by decreasing secretion of active metabolite of vitamin D and antagonizing phosphate resorption in renal tubules. Vitamin D 179-188 fibroblast growth factor 23 Homo sapiens 0-5 26715761-0 2016 Epigenome-wide effects of vitamin D and their impact on the transcriptome of human monocytes involve CTCF. Vitamin D 26-35 CCCTC-binding factor Homo sapiens 101-105 26715761-1 2016 The physiological functions of vitamin D are mediated by its metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) activating the transcription factor vitamin D receptor (VDR). Vitamin D 31-40 vitamin D receptor Homo sapiens 152-170 26715761-1 2016 The physiological functions of vitamin D are mediated by its metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) activating the transcription factor vitamin D receptor (VDR). Vitamin D 31-40 vitamin D receptor Homo sapiens 172-175 27489574-3 2016 However, the various U-shaped associations for allergic reactions may be due to vitamin D modulation of the phenotype of the immune response, shifting the Th1-Th2 balance toward Th2 formation. Vitamin D 80-89 negative elongation factor complex member C/D Homo sapiens 155-158 26991835-2 2016 The basis of the interplay between vitamin D and reproduction lays on the presence of both vitamin D receptor (VDR) and 1alpha-hydroxylase (CYP27B1) enzyme in reproductive organs. Vitamin D 35-44 vitamin D receptor Homo sapiens 91-109 26991835-2 2016 The basis of the interplay between vitamin D and reproduction lays on the presence of both vitamin D receptor (VDR) and 1alpha-hydroxylase (CYP27B1) enzyme in reproductive organs. Vitamin D 35-44 vitamin D receptor Homo sapiens 111-114 27032111-13 2016 The patients with optimal vitamin D status [25(OH)D >=75 nmol/l] had lower plasma levels of CCL7 (P = 0.047) and basic fibroblast growth factor (P = 0.042). Vitamin D 26-35 C-C motif chemokine ligand 7 Homo sapiens 95-99 26893158-8 2016 Intriguingly, the anti-inflammatory effects of vitamin D metabolites were only observed in CFTR knockdown cells, which may be explained by alterations in its catabolism associated with changes in CYP24A1 expression. Vitamin D 47-56 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 196-203 26934299-6 2016 We show that vitamin D signaling inhibits the expression of the tumor progression gene Id1, and this pathway is abrogated in vitamin D deficiency in vivo in 2 murine models of BCa. Vitamin D 13-22 inhibitor of DNA binding 1, HLH protein Mus musculus 87-90 26513524-1 2016 BACKGROUND AND AIM: The vitamin D receptor (VDR) regulates immune responses and inflammation through binding with 1,25-dihydroxyvitamin D, the active form of vitamin D. Vitamin D 24-33 vitamin D receptor Homo sapiens 44-47 26694996-0 2016 Increase of circulating cholesterol in vitamin D deficiency is linked to reduced vitamin D receptor activity via the Insig-2/SREBP-2 pathway. Vitamin D 39-48 vitamin D receptor Homo sapiens 81-99 26694996-6 2016 Under vitamin D deficiency, the transcriptional activity of vitamin D receptor (VDR) was decreased, leading to the downregulation of insulin-induced gene-2 (Insig-2) expression and thus its inhibitory role on sterol regulatory element-binding protein 2 activation; 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression was accordingly increased. Vitamin D 6-15 vitamin D receptor Homo sapiens 60-78 26694996-6 2016 Under vitamin D deficiency, the transcriptional activity of vitamin D receptor (VDR) was decreased, leading to the downregulation of insulin-induced gene-2 (Insig-2) expression and thus its inhibitory role on sterol regulatory element-binding protein 2 activation; 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression was accordingly increased. Vitamin D 6-15 vitamin D receptor Homo sapiens 80-83 26694996-7 2016 Vitamin D3 was protective against vitamin D deficiency-induced cholesterol increase by maintaining the transcriptional activity of VDR and Insig-2 expression. Vitamin D 34-43 vitamin D receptor Homo sapiens 131-134 26694996-8 2016 CONCLUSION: Vitamin D deficiency is associated with the increase of circulating cholesterol in the people of northern China by enhancing hepatic cholesterol biosynthesis, which was linked to the reduction of transcriptional activity of VDR. Vitamin D 12-21 vitamin D receptor Homo sapiens 236-239 27001276-10 2016 Taken together, we provide evidence that vitamin D balance in the presence of hyperglycemia is strongly associated with serum adiponectin levels and reduced renal renin-angiotensin system signaling. Vitamin D 41-50 adiponectin, C1Q and collagen domain containing Rattus norvegicus 126-137 26476373-4 2016 A relevant number of studies support the notion that FGF23, a bone-derived hormone, not only regulates the most important mineral metabolism (MM) related factors (phosphate, parathyroid hormone, vitamin D, etc. Vitamin D 195-204 fibroblast growth factor 23 Homo sapiens 53-58 28808527-4 2016 The present ligand is the first secosteroidal analog with the carborane unit that efficiently binds to VDR and functions as an agonist with 1,25D-like potency in transcriptional assay on vitamin D target genes. Vitamin D 187-196 vitamin D receptor Homo sapiens 103-106 26813507-1 2016 FGF23-related hypophosphatemic rickets is basically treated with active vitamin D and phosphorus. Vitamin D 72-81 fibroblast growth factor 23 Homo sapiens 0-5 26784540-1 2016 Overexpression of FGF23 results in hypophosphatemic rickets, which is characterized by renal phosphate wasting, inappropriately low circulating levels of the active form of vitamin D, and skeletal abnormalities. Vitamin D 173-182 fibroblast growth factor 23 Homo sapiens 18-23 26784540-3 2016 In this issue of the JCI, Bai and colleagues demonstrate that deletion or inhibition of CYP24A1, which initiates degradation of the active form of vitamin D, ameliorates skeletal abnormalities in two mouse models of hypophosphatemic rickets. Vitamin D 147-156 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 88-95 26784541-1 2016 CYP24A1 (hereafter referred to as CYP24) enzymatic activity is pivotal in the inactivation of vitamin D metabolites. Vitamin D 94-103 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 0-7 26784541-1 2016 CYP24A1 (hereafter referred to as CYP24) enzymatic activity is pivotal in the inactivation of vitamin D metabolites. Vitamin D 94-103 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 0-5 26643910-0 2016 Thyroid hormone and vitamin D regulate VGF expression and promoter activity. Vitamin D 20-29 VGF nerve growth factor inducible Homo sapiens 39-42 26643910-6 2016 In silico studies identified possible thyroid and vitamin D response elements in the VGF promoter. Vitamin D 50-59 VGF nerve growth factor inducible Homo sapiens 85-88 26501157-4 2016 Clinicians should be aware that even therapeutic doses of vitamin D can prove harmful for patients with CYP24A1 mutations. Vitamin D 58-67 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 104-111 26766742-11 2016 The variant is located near CYP24A1, which encodes an enzyme involved in vitamin D metabolism. Vitamin D 73-82 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 28-35 26238339-2 2016 We hypothesised that cells overexpressing CYP24A1 have growth advantage and a diet rich in vitamin D and soy would restore sensitivity to the anti-tumourigenic effects of vitamin D. Vitamin D 171-180 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 42-49 26751954-1 2016 BACKGROUND: Vitamin-D-binding protein (VDBP) is a low molecular weight protein that is filtered through the glomerulus as a 25-(OH) vitamin D 3/VDBP complex. Vitamin D 132-141 GC vitamin D binding protein Homo sapiens 39-43 26751954-1 2016 BACKGROUND: Vitamin-D-binding protein (VDBP) is a low molecular weight protein that is filtered through the glomerulus as a 25-(OH) vitamin D 3/VDBP complex. Vitamin D 132-141 GC vitamin D binding protein Homo sapiens 144-148 27195054-9 2016 In conclusion, the inflammatory cytokine TNF increases the response of keratinocytes to calcitriol through upregulation of its receptor VDR, which in turn is subject to negative feedback by the hormone accelerating the return of the keratinocyte vitamin D system to its basal activity. Vitamin D 246-255 vitamin D receptor Homo sapiens 136-139 26654942-9 2016 Studies employing VDR siRNA, CYP27B1 zinc finger nucleases, and pharmacologic inhibitors of the vitamin D pathway indicate that 25D3 regulates gene expression in a VDR-dependent manner but does not strictly require 1alphaOHase-mediated conversion of 25D3 to 1,25D3. Vitamin D 96-105 vitamin D receptor Homo sapiens 164-167 26453697-2 2016 One possible explanation for this attenuation is different concentrations of bioavailable vitamin D metabolites in plasma, which are estimated with equations that include the total concentration of vitamin D binding globulin (VDBG) and haplotype-specific dissociation constants. Vitamin D 90-99 GC vitamin D binding protein Homo sapiens 198-224 26453697-2 2016 One possible explanation for this attenuation is different concentrations of bioavailable vitamin D metabolites in plasma, which are estimated with equations that include the total concentration of vitamin D binding globulin (VDBG) and haplotype-specific dissociation constants. Vitamin D 90-99 GC vitamin D binding protein Homo sapiens 226-230 27252739-4 2016 In vitamin D switch group [RLX or BP plus alfacalcidol (ALF) and then switched to RLX or BP plus ELD, n=215], the replacing ALF with ELD further and significantly decreased TRACP-5b and tertile analyses based on baseline values were significantly decreased far more in the highest, compared with the lowest tertile in the ELD+RLX and ELD+BP groups. Vitamin D 3-12 acid phosphatase 5, tartrate resistant Homo sapiens 173-181 26479950-1 2016 The discovery of vitamin D receptor (VDR) expression in immune cells has opened up a new area of research into immunoregulation by vitamin D, a niche that is distinct from its classical role in skeletal health. Vitamin D 17-26 vitamin D receptor Homo sapiens 37-40 26488808-0 2016 Vitamin D Regulates Fatty Acid Composition in Subcutaneous Adipose Tissue Through Elovl3. Vitamin D 0-9 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 Mus musculus 82-88 26488808-9 2016 We also demonstrate that Elovl3 is regulated by vitamin D in vivo and tissue specifically in the sc WAT depot. Vitamin D 48-57 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 Mus musculus 25-31 26446551-5 2016 However, plasma levels of vitamin D binding protein isotype 1 and alpha1-antitrypsin isotypes 2, 3 and 4 were significantly decreased in BRCA2 mutation carriers compared to controls. Vitamin D 26-35 BRCA2 DNA repair associated Homo sapiens 137-142 26827947-3 2016 Current studies are now refocused on the vitamin D hormone"s action at the genome, where VDR together with other transcription factors coordinates the recruitment of chromatin active coregulatory complexes that participate directly in the modification of gene output. Vitamin D 41-50 vitamin D receptor Homo sapiens 89-92 26827947-8 2016 These studies advance our understanding of not only vitamin D action but also of the complex and dynamic role played by the genome itself as a major determinant of VDR activity. Vitamin D 52-61 vitamin D receptor Homo sapiens 164-167 26827949-8 2016 Additionally, we describe the crystal structures of VDR mutants associated with hereditary vitamin D-resistant rickets that display impaired ligand-binding function. Vitamin D 91-100 vitamin D receptor Homo sapiens 52-55 26827951-1 2016 One of the most pronounced effects of the hormonally active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), is increased synthesis of 25-hydroxyvitamin D3 24-hydroxylase (CYP24A1), the enzyme responsible for the catabolism of 1,25(OH)2D3. Vitamin D 68-77 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 182-189 26827953-1 2016 1,25-Dihydroxyvitamin D3 (1,25D) is the renal metabolite of vitamin D that signals through binding to the nuclear vitamin D receptor (VDR). Vitamin D 14-23 vitamin D receptor Homo sapiens 114-132 26827953-1 2016 1,25-Dihydroxyvitamin D3 (1,25D) is the renal metabolite of vitamin D that signals through binding to the nuclear vitamin D receptor (VDR). Vitamin D 14-23 vitamin D receptor Homo sapiens 134-137 27125741-3 2016 The discovery of KL as a partner for FGF23 led to significant advances in understanding of the molecular mechanisms underlying phosphate and vitamin D metabolism, and simultaneously clarified the pathogenic roles of the FGF23 signaling pathway in human diseases. Vitamin D 141-150 klotho Homo sapiens 17-19 27125741-3 2016 The discovery of KL as a partner for FGF23 led to significant advances in understanding of the molecular mechanisms underlying phosphate and vitamin D metabolism, and simultaneously clarified the pathogenic roles of the FGF23 signaling pathway in human diseases. Vitamin D 141-150 fibroblast growth factor 23 Homo sapiens 37-42 27125741-4 2016 These novel insights led to the development of new strategies to combat disorders associated with the dysregulated metabolism of phosphate and vitamin D, and clinical trials on the blockade of FGF23 signaling in X-linked hypophosphatemic rickets are ongoing. Vitamin D 143-152 fibroblast growth factor 23 Homo sapiens 193-198 26644513-5 2015 Using pharmacological and knockdown approaches we show that RXR-VDR signaling induces OPC differentiation and that VDR agonist vitamin D enhances OPC differentiation. Vitamin D 127-136 vitamin D receptor Homo sapiens 115-118 26416604-6 2015 The T allele (vitamin-D-increasing allele) of DHCR7 rs12785878 was associated with greater decreases in insulin and HOMA-IR (p < 0.002) in response to high-protein diets, while there was no significant genotype effect on changes in these traits in the low-protein diet group. Vitamin D 14-23 7-dehydrocholesterol reductase Homo sapiens 46-51 26641549-8 2015 RESULTS: When treated with inactive vitamin D metabolites, HCEC produced active 1,25D3, leading to enhanced expression of the antimicrobial peptide, LL-37, dependent on VDR. Vitamin D 36-45 vitamin D receptor Homo sapiens 169-172 26501255-12 2015 We also suggest that vitamin D-based therapies may represent an adjuvant strategy in treatment for bladder cancers expressing VDR. Vitamin D 21-30 vitamin D receptor Homo sapiens 126-129 26770399-7 2015 Both the mean fluorescence intensity and the positive percentage of monocytes TLR4 in the vitamin D group were significantly lower compared to the placebo group, as well as the concentrations of secreted TNF-alpha, IL-6, and IL-1, while the concentration of IL-10 was higher. Vitamin D 90-99 interleukin 10 Homo sapiens 258-263 26224799-2 2015 Variants in the vitamin D receptor (VDR) gene have the potential to modify associations between vitamin D intake and colorectal cancer. Vitamin D 16-25 vitamin D receptor Homo sapiens 36-39 26196951-1 2015 CONTEXT: Vitamin D binding protein (DBP) is an important determinant of bioavailable vitamin D (BAVD) and may provide clues to racial variation in osteoporosis and atherosclerosis. Vitamin D 85-94 GC vitamin D binding protein Homo sapiens 9-34 25878189-5 2015 The VDR gene is additionally examined as a factor in the evolutionary selection of skin depigmentation at higher latitudes to allow vitamin D synthesis. Vitamin D 132-141 vitamin D receptor Homo sapiens 4-7 26312598-11 2015 A 6.7-fold increased odds of AMD (95% CI, 1.6-28.2) was observed among women with deficient vitamin D status (25[OH]D <12 ng/mL) and 2 risk alleles for CFH Y402H (SI for additive interaction, 1.4; 95% CI, 1.1-1.7; P for multiplicative interaction = .25). Vitamin D 92-101 complement factor H Homo sapiens 155-158 26312598-14 2015 CONCLUSIONS AND RELEVANCE: In this study, the odds of AMD were highest in those with deficient vitamin D status and 2 risk alleles for the CFH and CFI genotypes, suggesting a synergistic effect between vitamin D status and complement cascade protein function. Vitamin D 202-211 complement factor H Homo sapiens 139-142 26312598-14 2015 CONCLUSIONS AND RELEVANCE: In this study, the odds of AMD were highest in those with deficient vitamin D status and 2 risk alleles for the CFH and CFI genotypes, suggesting a synergistic effect between vitamin D status and complement cascade protein function. Vitamin D 202-211 complement factor I Homo sapiens 147-150 26448018-1 2015 To investigate whether single nucleotide polymorphisms (SNPs) within 4 representative genes (VDR, GC, CYP2R1, and CYP24A1) encoding the core proteins involved in vitamin D production, degradation, and ligand-dependent signaling pathway are associated with gestational diabetes mellitus (GDM) in a Chinese population. Vitamin D 162-171 vitamin D receptor Homo sapiens 93-96 26448018-1 2015 To investigate whether single nucleotide polymorphisms (SNPs) within 4 representative genes (VDR, GC, CYP2R1, and CYP24A1) encoding the core proteins involved in vitamin D production, degradation, and ligand-dependent signaling pathway are associated with gestational diabetes mellitus (GDM) in a Chinese population. Vitamin D 162-171 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 114-121 26904855-3 2015 Vitamin D metabolic enzymes synthesize and degrade active vitamin D3 and its metabolic intermediates, and active vitamin D3 exerts its biological effects through binding to vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 173-191 26904855-3 2015 Vitamin D metabolic enzymes synthesize and degrade active vitamin D3 and its metabolic intermediates, and active vitamin D3 exerts its biological effects through binding to vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 193-196 26504744-3 2015 Recent studies connected the gene encoding for vitamin D (VDR) to the genetic control of bone mass and other diseases. Vitamin D 47-56 vitamin D receptor Homo sapiens 58-61 26346690-1 2015 BACKGROUND: Polymorphisms in the vitamin D receptor (VDR) gene have been studied in immune-related disorders either as independent contributors or in combination with vitamin D concentration. Vitamin D 33-42 vitamin D receptor Homo sapiens 53-56 26489816-4 2015 Here, we describe a case of hypersensitivity to vitamin D by mutation of CYP24A1. Vitamin D 48-57 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 73-80 25920689-2 2015 Racial differences in fracture risk may be related to differences in bioavailable vitamin D due to single nucleotide polymorphism (SNP) variations in the vitamin D binding protein (DBP). Vitamin D 82-91 GC vitamin D binding protein Homo sapiens 154-179 25931412-5 2015 Active vitamin D analogs, capable of binding the vitamin D receptor evoking vitamin D-related biological effects, are mandatorily employed in hypoparathyroidism and kidney failure with impaired 1alpha-hydroxylation. Vitamin D 7-16 vitamin D receptor Homo sapiens 49-67 26071405-0 2015 1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D. Vitamin D 14-23 tryptophan hydroxylase 2 Homo sapiens 52-76 25641222-8 2015 Vitamin D analogues may provide a therapeutic choice for patients with high VDR expression in tumours but a low vitamin D level in the circulation. Vitamin D 0-9 vitamin D receptor Homo sapiens 76-79 26637501-9 2015 Also, anti-TPO levels were significantly higher in 186/218 vitamin D deficient HT patients compared to 32/218 HT patients with no vitamin D deficiency (364 +- 181IU/mL versus 115.8 +- 37.1IU/mL, P<0.0001). Vitamin D 59-68 thyroid peroxidase Homo sapiens 11-14 26637501-9 2015 Also, anti-TPO levels were significantly higher in 186/218 vitamin D deficient HT patients compared to 32/218 HT patients with no vitamin D deficiency (364 +- 181IU/mL versus 115.8 +- 37.1IU/mL, P<0.0001). Vitamin D 130-139 thyroid peroxidase Homo sapiens 11-14 26637501-10 2015 Supplementation of CF in 186 vitamin D deficient HT patients caused a significant decrease (20.3%) in serum anti-TPO levels. Vitamin D 29-38 thyroid peroxidase Homo sapiens 113-116 26637501-14 2015 After 4 months of CF supplementation in the 186 HT patients with vitamin D deficiency, a significant decrease (20.3%) of serum anti-TPO levels was found. Vitamin D 65-74 thyroid peroxidase Homo sapiens 132-135 26348637-10 2015 The results strengthen the hypothesis that megalin and cubilin are likely involved in the secretory pathway of vitamin D into tear fluid by the duct cells. Vitamin D 111-120 cubilin (intrinsic factor-cobalamin receptor) Mus musculus 55-62 25748032-2 2015 Vitamin D also regulates mineral homeostasis and upregulates klotho expression. Vitamin D 0-9 klotho Homo sapiens 61-67 25837735-6 2015 From this holistic viewpoint, we offer new insights into an old debate: whether vitamin D"s effects in the musculoskeletal system are direct via local VDR signals or indirect via its systemic effects in calcium and phosphate homeostasis. Vitamin D 80-89 vitamin D receptor Homo sapiens 151-154 25934099-9 2015 KLOTHO/fibroblast growth factor 23 (FGF23) contribute to control Ca(2+), phosphate, and vitamin D metabolism, and their dysregulation may participate in age-related disease. Vitamin D 88-97 klotho Homo sapiens 0-6 25934099-9 2015 KLOTHO/fibroblast growth factor 23 (FGF23) contribute to control Ca(2+), phosphate, and vitamin D metabolism, and their dysregulation may participate in age-related disease. Vitamin D 88-97 fibroblast growth factor 23 Homo sapiens 7-34 25934099-9 2015 KLOTHO/fibroblast growth factor 23 (FGF23) contribute to control Ca(2+), phosphate, and vitamin D metabolism, and their dysregulation may participate in age-related disease. Vitamin D 88-97 fibroblast growth factor 23 Homo sapiens 36-41 25873553-3 2015 This pilot study explores if vitamin D supplementation could reduce serum concentrations of inflammatory cytokines (interleukin [IL] 6, IL-10, tumor necrosis factor alpha), adiponectin, lipids, hemoglobin A1C, and high-sensitivity C-reactive protein (hs-CRP). Vitamin D 29-38 interleukin 10 Homo sapiens 136-141 26403394-5 2015 Vitamin D binds its receptor VDR, resulting in transcription of a number of genes playing a role in inhibition of MAPK. Vitamin D 0-9 vitamin D receptor Homo sapiens 29-32 26347327-6 2015 Fibroblast growth factor23 (FGF23) is a bone-derived hormone that plays an important role in the regulation of phosphate and vitamin D metabolism. Vitamin D 125-134 fibroblast growth factor 23 Homo sapiens 0-26 26347327-6 2015 Fibroblast growth factor23 (FGF23) is a bone-derived hormone that plays an important role in the regulation of phosphate and vitamin D metabolism. Vitamin D 125-134 fibroblast growth factor 23 Homo sapiens 28-33 25716068-3 2015 The placenta as an important source of vitamin D regulates its metabolism through the vitamin D receptor (VDR), but the mechanism by which VDR regulates trophoblast function is poorly understood. Vitamin D 39-48 vitamin D receptor Homo sapiens 86-104 25716068-3 2015 The placenta as an important source of vitamin D regulates its metabolism through the vitamin D receptor (VDR), but the mechanism by which VDR regulates trophoblast function is poorly understood. Vitamin D 39-48 vitamin D receptor Homo sapiens 106-109 25661837-2 2015 One such environmental factor is vitamin D, a vital hormone that plays a specific function in the immune system homeostasis, acting through a nuclear receptor (VDR) expressed in all immune cells. Vitamin D 33-42 vitamin D receptor Homo sapiens 160-163 26005021-2 2015 Signaling of vitamin D is mediated via its ubiquitously expressed nuclear receptor, the vitamin D receptor (VDR). Vitamin D 13-22 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 88-106 26005021-2 2015 Signaling of vitamin D is mediated via its ubiquitously expressed nuclear receptor, the vitamin D receptor (VDR). Vitamin D 13-22 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 108-111 25326845-0 2015 Vitamin D prevents the intestinal fibrosis via induction of vitamin D receptor and inhibition of transforming growth factor-beta1/Smad3 pathway. Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 60-78 25326845-12 2015 CONCLUSIONS: Vitamin D has prophylactic effect on intestinal fibrosis in the vitamin D-deficient mice with chronic colitis, which may be associated with the inhibited activation of TGF-beta1/Smad3 pathway in the SEMF via VDR induction. Vitamin D 13-22 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 221-224 25326845-12 2015 CONCLUSIONS: Vitamin D has prophylactic effect on intestinal fibrosis in the vitamin D-deficient mice with chronic colitis, which may be associated with the inhibited activation of TGF-beta1/Smad3 pathway in the SEMF via VDR induction. Vitamin D 77-86 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 221-224 25637936-6 2015 DHCR7 is important for both cholesterol and vitamin D synthesis, and we have identified a novel layer of regulation, whereby its activity is controlled by DHCR24. Vitamin D 44-53 7-dehydrocholesterol reductase Homo sapiens 0-5 25237033-1 2015 Vitamin D has pleiotropic extra-skeletal effects which have been noted in mouse models of deletion of either the 25-hydroxy vitamin D 1alpha-hydroxylase enzyme, cyp27b1 (1OHase(-/-) mice) or of the vitamin D receptor (Vdr(-/-) mice); these may be preventable or reversible by either restoring normal signaling of the 1,25(OH)2D/VDR system, or in some cases by restoring normal mineral homeostasis. Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 198-216 25237033-1 2015 Vitamin D has pleiotropic extra-skeletal effects which have been noted in mouse models of deletion of either the 25-hydroxy vitamin D 1alpha-hydroxylase enzyme, cyp27b1 (1OHase(-/-) mice) or of the vitamin D receptor (Vdr(-/-) mice); these may be preventable or reversible by either restoring normal signaling of the 1,25(OH)2D/VDR system, or in some cases by restoring normal mineral homeostasis. Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 218-221 25237033-1 2015 Vitamin D has pleiotropic extra-skeletal effects which have been noted in mouse models of deletion of either the 25-hydroxy vitamin D 1alpha-hydroxylase enzyme, cyp27b1 (1OHase(-/-) mice) or of the vitamin D receptor (Vdr(-/-) mice); these may be preventable or reversible by either restoring normal signaling of the 1,25(OH)2D/VDR system, or in some cases by restoring normal mineral homeostasis. Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 328-331 25445919-6 2015 In MCF10DCIS cells treated with vitamin D compounds (1alpha25(OH)2D3 or BXL0124), the breast cancer stem cell-like population, identified by the CD44(+)/CD24(-/low) and CD49f(+)/CD24(-/low) subpopulations, was reduced. Vitamin D 32-41 CD44 molecule (Indian blood group) Homo sapiens 145-149 25445919-6 2015 In MCF10DCIS cells treated with vitamin D compounds (1alpha25(OH)2D3 or BXL0124), the breast cancer stem cell-like population, identified by the CD44(+)/CD24(-/low) and CD49f(+)/CD24(-/low) subpopulations, was reduced. Vitamin D 32-41 integrin subunit alpha 6 Homo sapiens 169-174 25446885-0 2015 Alterations in vitamin D metabolite, parathyroid hormone and fibroblast growth factor-23 concentrations in sclerostin-deficient mice permit the maintenance of a high bone mass. Vitamin D 15-24 sclerostin Mus musculus 107-117 25636720-5 2015 Other etiologies of vitamin D induced hypercalcemia include hyperparathyroidism, granulomatous malignancies like sarcoidosis and mutations in the CYP24A1 gene. Vitamin D 20-29 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 146-153 25644204-14 2015 Vitamin D regulating enzymes (CYP24A1, CYP2R1 and CYP27B1) expression were also altered in women with 25(OH)D3 deficiency. Vitamin D 0-9 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 30-37 25801892-2 2015 Recent studies highlight that vitamin D may exert actions on T-cells, inhibiting Th1 and Th17 response and enhancing Th2 and T-regulatory (T-reg) function. Vitamin D 30-39 negative elongation factor complex member C/D Homo sapiens 81-84 26338395-3 2015 New factors and hormones have been identified, such as Klotho and fibroblast growth factor-23 (FGF-23) that interact with vitamin D and the parathyroid hormone in the renal management of calcium and phosphorus. Vitamin D 122-131 klotho Homo sapiens 55-61 26338395-3 2015 New factors and hormones have been identified, such as Klotho and fibroblast growth factor-23 (FGF-23) that interact with vitamin D and the parathyroid hormone in the renal management of calcium and phosphorus. Vitamin D 122-131 fibroblast growth factor 23 Homo sapiens 66-93 26338395-3 2015 New factors and hormones have been identified, such as Klotho and fibroblast growth factor-23 (FGF-23) that interact with vitamin D and the parathyroid hormone in the renal management of calcium and phosphorus. Vitamin D 122-131 fibroblast growth factor 23 Homo sapiens 95-101 25852682-5 2015 Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3(+)CD4(+) T-regulatory cell and CD4(+) T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch. Vitamin D 83-92 negative elongation factor complex member C/D Homo sapiens 149-152 25852682-5 2015 Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3(+)CD4(+) T-regulatory cell and CD4(+) T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch. Vitamin D 83-92 negative elongation factor complex member C/D Homo sapiens 157-160 25595352-0 2015 Association between vitamin D concentration and levels of sex hormones in an elderly Polish population with different genotypes of VDR polymorphisms (rs10735810, rs1544410, rs7975232, rs731236). Vitamin D 20-29 vitamin D receptor Homo sapiens 131-134 25595352-2 2015 The aim of this study was to determine whether there is an association of vitamin D concentration vs the level of sex hormones in elderly Polish individuals with different genotypes of the vitamin D receptor (VDR) gene. Vitamin D 74-83 vitamin D receptor Homo sapiens 189-207 25595352-2 2015 The aim of this study was to determine whether there is an association of vitamin D concentration vs the level of sex hormones in elderly Polish individuals with different genotypes of the vitamin D receptor (VDR) gene. Vitamin D 74-83 vitamin D receptor Homo sapiens 209-212 25595352-6 2015 CONCLUSION: In elderly selected Polish population with different genotypes of VDR polymorphisms, a statistically significant relationship between vitamin D concentration vs testosterone level was observed. Vitamin D 146-155 vitamin D receptor Homo sapiens 78-81 25680585-0 2015 Interleukin-10 but not transforming growth factor-beta1 gene expression is up-regulated by vitamin D treatment in multiple sclerosis patients. Vitamin D 91-100 interleukin 10 Homo sapiens 0-14 25680585-4 2015 Therefore, this study aims to evaluate the effect of vitamin D treatment on the expression of interleukin-10 (IL-10) and transforming growth factor-beta1 (TGF-beta1) genes in MS patients. Vitamin D 53-62 interleukin 10 Homo sapiens 94-108 25680585-4 2015 Therefore, this study aims to evaluate the effect of vitamin D treatment on the expression of interleukin-10 (IL-10) and transforming growth factor-beta1 (TGF-beta1) genes in MS patients. Vitamin D 53-62 interleukin 10 Homo sapiens 110-115 25560187-1 2015 The vitamin D receptor (VDR) is a mediator for the cellular effects of vitamin D and interacts with other cell signaling pathways that influence cancer development. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 25575651-1 2015 A method for quantitative analysis of vitamin D (both D2 and D3) and its main metabolites - monohydroxylated vitamin D (25-hydroxyvitamin D2 and 25-hydroxyvitamin D3) and dihydroxylated metabolites (1,25-dihydroxyvitamin D2, 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3) in human serum is here reported. Vitamin D 38-47 immunoglobulin heavy diversity 2-15 Homo sapiens 54-63 25482012-0 2015 The transcriptional regulator BCL6 participates in the secondary gene regulatory response to vitamin D. Vitamin D 93-102 BCL6 transcription repressor Homo sapiens 30-34 25482012-1 2015 The vitamin D metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is the high affinity ligand of the transcription factor vitamin D receptor (VDR) and therefore a direct regulator of transcription. Vitamin D 4-13 vitamin D receptor Homo sapiens 120-138 25482012-1 2015 The vitamin D metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is the high affinity ligand of the transcription factor vitamin D receptor (VDR) and therefore a direct regulator of transcription. Vitamin D 4-13 vitamin D receptor Homo sapiens 140-143 25479835-10 2015 These findings suggest treatment with vitamin D compounds results in sustained increases in VDR in human skeletal muscle. Vitamin D 38-47 vitamin D receptor Homo sapiens 92-95 25716805-2 2015 Most of vitamin D actions mediate expression of target genes regulated by nuclear vitamin D receptor (VDR). Vitamin D 8-17 vitamin D receptor Homo sapiens 82-100 25716805-2 2015 Most of vitamin D actions mediate expression of target genes regulated by nuclear vitamin D receptor (VDR). Vitamin D 8-17 vitamin D receptor Homo sapiens 102-105 25716806-1 2015 Cross talks among vitamin D endocrine system, PTH and FGF23]. Vitamin D 18-27 fibroblast growth factor 23 Homo sapiens 54-59 25716810-4 2015 Besides such a classical role, vitamin D is known to exert multiple extra-skeletal actions through CYP27B1 and vitamin D receptor (VDR) that is expressed in a wide variety of extra-renal tissues and cell types. Vitamin D 31-40 vitamin D receptor Homo sapiens 111-129 25716810-4 2015 Besides such a classical role, vitamin D is known to exert multiple extra-skeletal actions through CYP27B1 and vitamin D receptor (VDR) that is expressed in a wide variety of extra-renal tissues and cell types. Vitamin D 31-40 vitamin D receptor Homo sapiens 131-134 25716811-3 2015 Active form of vitamin D binds to nuclear or non-nuclear vitamin D receptor (VDR) and regulates the proliferation and differentiation of myoblasts through its genomic or non-genomic actions. Vitamin D 15-24 vitamin D receptor Homo sapiens 57-75 25716811-3 2015 Active form of vitamin D binds to nuclear or non-nuclear vitamin D receptor (VDR) and regulates the proliferation and differentiation of myoblasts through its genomic or non-genomic actions. Vitamin D 15-24 vitamin D receptor Homo sapiens 77-80 25716814-3 2015 The active form of vitamin D, 1alpha, 25-dihydroxyvitamin D3 [1,25 (OH) 2D3], regulates numerous physiological and pharmacological processes, including bone and calcium homeostasis, cellular growth and differentiation, immunity, and cardiovascular function, through binding to the vitamin D receptor (VDR), a member of the nuclear receptor superfamily. Vitamin D 19-28 vitamin D receptor Homo sapiens 281-299 25716814-3 2015 The active form of vitamin D, 1alpha, 25-dihydroxyvitamin D3 [1,25 (OH) 2D3], regulates numerous physiological and pharmacological processes, including bone and calcium homeostasis, cellular growth and differentiation, immunity, and cardiovascular function, through binding to the vitamin D receptor (VDR), a member of the nuclear receptor superfamily. Vitamin D 19-28 vitamin D receptor Homo sapiens 301-304 25370319-0 2015 Low Vitamin D Status is Associated with Increased Thyrotropin-Receptor Antibody Titer in Graves Disease. Vitamin D 4-13 thyroid stimulating hormone receptor Homo sapiens 50-70 25370324-0 2015 Vitamin D binding protein gene polymorphism as a risk factor for vitamin D deficiency in Thais. Vitamin D 65-74 GC vitamin D binding protein Homo sapiens 0-25 25784096-0 2015 Vitamin D Modulates the Expression of IL-27 and IL-33 in the Central Nervous System in Experimental Autoimmune Encephalomyelitis (EAE). Vitamin D 0-9 interleukin 27 Mus musculus 38-43 25784096-0 2015 Vitamin D Modulates the Expression of IL-27 and IL-33 in the Central Nervous System in Experimental Autoimmune Encephalomyelitis (EAE). Vitamin D 0-9 interleukin 33 Mus musculus 48-53 25784096-2 2015 OBJECTIVE: To evaluate the effects of vitamin D on the expression of IL-27 and IL-33 in a model of experimental autoimmune encephalomyelitis (EAE). Vitamin D 38-47 interleukin 27 Mus musculus 69-74 25784096-2 2015 OBJECTIVE: To evaluate the effects of vitamin D on the expression of IL-27 and IL-33 in a model of experimental autoimmune encephalomyelitis (EAE). Vitamin D 38-47 interleukin 33 Mus musculus 79-84 25784096-9 2015 In vitamin D-treated EAE group, the expression of IL-27 P28 and IL-27 EBI3 were significantly higher compared with the olive oil-treated EAE groups (p<0.002 and p<0.04, respectively). Vitamin D 3-12 interleukin 27 Mus musculus 50-55 25784096-9 2015 In vitamin D-treated EAE group, the expression of IL-27 P28 and IL-27 EBI3 were significantly higher compared with the olive oil-treated EAE groups (p<0.002 and p<0.04, respectively). Vitamin D 3-12 interleukin 27 Mus musculus 64-69 25784096-11 2015 Vitamin D significantly decreased the expression of IL-33 compared with PBS- or olive oil-treated EAE mice (p<0.04, p<0.02, respectively). Vitamin D 0-9 interleukin 33 Mus musculus 52-57 25784096-15 2015 CONCLUSION: Vitamin D may modulate the expression of IL-27 and IL-33 in the spinal cord of EAE mice and also ameliorate the clinical symptoms of the disease. Vitamin D 12-21 interleukin 27 Mus musculus 53-58 25784096-15 2015 CONCLUSION: Vitamin D may modulate the expression of IL-27 and IL-33 in the spinal cord of EAE mice and also ameliorate the clinical symptoms of the disease. Vitamin D 12-21 interleukin 33 Mus musculus 63-68 25457999-0 2015 Vitamin D enhances production of soluble ST2, inhibiting the action of IL-33. Vitamin D 0-9 ST2 Homo sapiens 41-44 25201000-0 2015 Vitamin D-neutralizing CYP24A1 expression, oncogenic mutation states and histological findings of human papillary thyroid cancer. Vitamin D 0-9 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 23-30 25201000-1 2015 OBJECTIVE: The aims of the present study were to examine gene and protein expression of the vitamin D-inactivating 24-hyroxylase (CYP24A1) and the activating 1-alpha-hydroxylase (CYP27B1) enzyme in human papillary thyroid cancer (PTC), furthermore, to investigate the association between CYP24A1 expression and numerous clinical, histological parameters and somatic oncogene mutation status of thyroid tumor tissues. Vitamin D 92-101 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 130-137 25201000-1 2015 OBJECTIVE: The aims of the present study were to examine gene and protein expression of the vitamin D-inactivating 24-hyroxylase (CYP24A1) and the activating 1-alpha-hydroxylase (CYP27B1) enzyme in human papillary thyroid cancer (PTC), furthermore, to investigate the association between CYP24A1 expression and numerous clinical, histological parameters and somatic oncogene mutation status of thyroid tumor tissues. Vitamin D 92-101 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 288-295 24620922-11 2015 CONCLUSIONS: In community-dwelling elderly individuals with highly prevalent vitamin D deficiency, FGF-23 levels were associated with LV hypertrophy and predicted mortality independently of two robust cardiac biomarkers. Vitamin D 77-86 fibroblast growth factor 23 Homo sapiens 99-105 26528423-5 2015 Membrane Klotho forms a complex with fibroblast growth factor (FGF) receptors, functions as an obligatory co-receptor for FGF23, which is involved in aging and the development of chronic diseases via regulation of P i and vitamin D metabolism. Vitamin D 222-231 klotho Mus musculus 9-15 26528423-5 2015 Membrane Klotho forms a complex with fibroblast growth factor (FGF) receptors, functions as an obligatory co-receptor for FGF23, which is involved in aging and the development of chronic diseases via regulation of P i and vitamin D metabolism. Vitamin D 222-231 fibroblast growth factor 23 Mus musculus 63-66 26528423-5 2015 Membrane Klotho forms a complex with fibroblast growth factor (FGF) receptors, functions as an obligatory co-receptor for FGF23, which is involved in aging and the development of chronic diseases via regulation of P i and vitamin D metabolism. Vitamin D 222-231 fibroblast growth factor 23 Mus musculus 122-127 25495694-5 2015 Our results indicate that repression by calcitriol occurs at the transcriptional level and involves a functional negative vitamin D response element (nVDRE) E-box type in the hEAG1 promoter. Vitamin D 122-131 potassium voltage-gated channel subfamily H member 1 Homo sapiens 175-180 25421379-9 2015 CONCLUSION: Breast cancer risk may be associated with specific vitamin D-related polymorphisms, particularly CYP24A1. Vitamin D 63-72 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 109-116 24803230-2 2015 Vitamin D has several immunomodulatory effects through vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 55-73 24803230-2 2015 Vitamin D has several immunomodulatory effects through vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 75-78 25510482-6 2015 Altogether, vitamin D-deficient TB patients expressed a weak antimicrobial response but an IL-21 associated expansion of IgG-secreting B cells combined with a rise in FoxP3(+) regulatory T cells at the local site of infection. Vitamin D 12-21 interleukin 21 Homo sapiens 91-96 25407646-5 2015 Vitamin D mediates its effect through binding to vitamin D receptor (VDR), which is harbored on many human immune cells, and in this way is able to modulate immune cells activity, triggering both innate and adaptive immune responses. Vitamin D 0-9 vitamin D receptor Homo sapiens 49-67 25407646-5 2015 Vitamin D mediates its effect through binding to vitamin D receptor (VDR), which is harbored on many human immune cells, and in this way is able to modulate immune cells activity, triggering both innate and adaptive immune responses. Vitamin D 0-9 vitamin D receptor Homo sapiens 69-72 25407646-6 2015 As VDR gene polymorphisms were found to associate with AITD, the evidence links vitamin D deficiency to AITD either through gene polymorphism or by environmental factors (lack of dietary uptake and sun exposure). Vitamin D 80-89 vitamin D receptor Homo sapiens 3-6 26319903-3 2015 VDR is a crucial mediator for the cellular effects of vitamin D and conflicting data have been reported for most malignancies. Vitamin D 54-63 vitamin D receptor Homo sapiens 0-3 25527766-2 2015 In the Food with vitamin D (VitmaD) study, we showed that common genetic variants rs10741657 and rs10766197 in 25-hydroxylase (CYP2R1) and rs842999 and rs4588 in vitamin D binding protein (GC) predict 25(OH)D concentrations at late summer and after 6-mo consumption of cholecalciferol (vitamin D3)-fortified bread and milk. Vitamin D 17-26 GC vitamin D binding protein Homo sapiens 162-187 25446019-0 2015 Kidney function and influence of sunlight exposure in patients with impaired 24-hydroxylation of vitamin D due to CYP24A1 mutations. Vitamin D 97-106 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 114-121 25446019-1 2015 Loss-of-function mutations of CYP24A1, the enzyme that converts the major circulating and active forms of vitamin D to inactive metabolites, recently have been implicated in idiopathic infantile hypercalcemia. Vitamin D 106-115 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 30-37 26693712-1 2015 BACKGROUND: Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone implicated in disorders of serum phosphorus concentration and vitamin D. Vitamin D 136-145 fibroblast growth factor 23 Homo sapiens 12-39 26693712-1 2015 BACKGROUND: Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone implicated in disorders of serum phosphorus concentration and vitamin D. Vitamin D 136-145 fibroblast growth factor 23 Homo sapiens 41-46 25773805-1 2015 Much interest has been drawn to possible associations between vitamin D receptor (VDR) gene polymorphisms and colorectal cancer risk in conjunction with potentially protective effects of calcium and vitamin D. Vitamin D 62-71 vitamin D receptor Homo sapiens 82-85 25739891-2 2015 While several studies have revealed that Fgf23 plays important roles in the regulation of phosphate and vitamin D metabolism, the additional physiological roles of Fgf23 remain unclear. Vitamin D 104-113 fibroblast growth factor 23 Mus musculus 41-46 31260744-0 2019 Vitamin D deficiency during pregnancy affects the function of Th1/Th2 cells and methylation of IFN-gamma gene in offspring rats. Vitamin D 0-9 interferon gamma Rattus norvegicus 95-104 31260744-9 2019 In conclusion, maternal vitamin D deficiency affected the function of Th1/Th2 cells and methylation of IFN-gamma gene in offspring rats. Vitamin D 24-33 interferon gamma Rattus norvegicus 103-112 30624776-0 2019 A variant in CYP2R1 predicts circulating vitamin D levels after supplementation with high-dose of vitamin D in healthy adolescent girls. Vitamin D 41-50 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 13-19 30624776-0 2019 A variant in CYP2R1 predicts circulating vitamin D levels after supplementation with high-dose of vitamin D in healthy adolescent girls. Vitamin D 98-107 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 13-19 30624776-12 2019 CONCLUSION: Based on our findings, it appears that the rs10741657 variant of the CYP2R1 gene modulates the response to high-dose of vitamin D supplementation. Vitamin D 132-141 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 81-87 30821057-9 2019 In the adjusted model, individuals who had vitamin D levels >19 ng mL-1 showed a lower prevalence of cognitive decline (prevalence ratio = 0.59; 95% confidence interval = 0.39-0.87). Vitamin D 43-52 L1 cell adhesion molecule Mus musculus 67-71 30821057-11 2019 CONCLUSIONS: The present study showed that individuals aged >=80 years who had vitamin D levels of <=18 ng mL-1 had a higher prevalence of cognitive decline even after adjustment for potential confounders. Vitamin D 79-88 L1 cell adhesion molecule Mus musculus 107-111 30802957-7 2019 Effect of vitamin D on basal IL-1alpha expression in mice was determined by topical administration to the gingiva of wild-type mice, followed by qRT-PCR. Vitamin D 10-19 interleukin 1 alpha Mus musculus 29-38 31375839-10 2019 Although CTX levels declined by 26.4% +- 5.3% (P = 0.0002) in NWB individuals (as anticipated), vitamin D supplementation resulted in an unexpected 25.8% +- 8% increase (P = 0.01) in CTX in LWB individuals, suggesting osteoclast activation. Vitamin D 96-105 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 183-186 31311491-1 2019 BACKGROUND: This study aimed to evaluate the association between serum vitamin D levels and nonalcoholic fatty liver disease (NAFLD) parameters, such as metabolic syndrome (MS), inflammatory cytokines (tumor necrosis factor, high sensitive C-reactive protein) and adipokines (adiponectin, leptin). Vitamin D 71-80 leptin Homo sapiens 289-295 31311491-10 2019 Vitamin D level was positively correlated with age and male, but negatively correlated with serum leptin level. Vitamin D 0-9 leptin Homo sapiens 98-104 31311491-11 2019 CONCLUSION: Subjects with low vitamin D level had higher odds for MS, but higher levels of leptin, compared to those with high vitamin D levels. Vitamin D 30-39 leptin Homo sapiens 91-97 30683615-5 2019 Multivariate analysis revealed that cold season, advanced fibrosis, and CYP2R1 rs1993116 genotype non-AA were independent factors significantly associated with vitamin D deficiency. Vitamin D 160-169 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 72-78 30731172-8 2019 Topical steroids alone or in combination with topical vitamin D analogues were suggested for nail psoriasis limited to the nail bed. Vitamin D 54-63 CD244 molecule Homo sapiens 93-97 30731172-8 2019 Topical steroids alone or in combination with topical vitamin D analogues were suggested for nail psoriasis limited to the nail bed. Vitamin D 54-63 CD244 molecule Homo sapiens 123-127 30830987-8 2019 BRD4 plays a critical role in histone modification and gene transcription, and cDNA expression profiling, using kidneys from Brd4+/M149T and Brd4+/+ mice, revealed differential expression of genes involved in vitamin D metabolism, cell differentiation, and apoptosis. Vitamin D 209-218 bromodomain containing 4 Mus musculus 0-4 30830987-8 2019 BRD4 plays a critical role in histone modification and gene transcription, and cDNA expression profiling, using kidneys from Brd4+/M149T and Brd4+/+ mice, revealed differential expression of genes involved in vitamin D metabolism, cell differentiation, and apoptosis. Vitamin D 209-218 bromodomain containing 4 Mus musculus 125-129 30830987-8 2019 BRD4 plays a critical role in histone modification and gene transcription, and cDNA expression profiling, using kidneys from Brd4+/M149T and Brd4+/+ mice, revealed differential expression of genes involved in vitamin D metabolism, cell differentiation, and apoptosis. Vitamin D 209-218 bromodomain containing 4 Mus musculus 141-145 30993743-1 2019 BACKGROUND: The circulating concentration of 25(OH)D is widely applied to indicate the vitamin D status, as the directly metabolic genes of 25(OH)D, CYP2R1, and CYP27B1 are associated with the concentration of 25(OH)D. Vitamin D 87-96 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 149-155 30993743-3 2019 We aimed at investigating the family-based association between SNPs of CYP2R1 and CYP27B1 and vitamin D deficiency. Vitamin D 94-103 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 71-77 30867220-0 2019 Intratumoral Sterol-27-Hydroxylase (CYP27A1) Expression in Relation to Cholesterol Synthesis and Vitamin D Signaling and Its Association with Lethal Prostate Cancer. Vitamin D 97-106 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 13-34 30867220-0 2019 Intratumoral Sterol-27-Hydroxylase (CYP27A1) Expression in Relation to Cholesterol Synthesis and Vitamin D Signaling and Its Association with Lethal Prostate Cancer. Vitamin D 97-106 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 36-43 30867220-3 2019 We hypothesized that low CYP27A1 expression is associated with high cholesterol synthesis, low vitamin D signaling, and higher risk of lethal prostate cancer. Vitamin D 95-104 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 25-32 30937698-6 2019 Conversely, Vitamin D increases glial tumor synthesis of neutrophins NGF and NT-3, the low affinity neurotrophin receptor p75NTR, IL-6 and VEGF, which may enhance glioma growth. Vitamin D 12-21 nerve growth factor receptor Homo sapiens 87-128 30661440-6 2019 Increased MAP1LC3B/LC3 expression corroborated with complete autolysosome formation detected by electron microscopy and correlated with degradation of SQSTM1/p62 in the skin following vitamin D treatment. Vitamin D 184-193 microtubule-associated protein 1 light chain 3 alpha Mus musculus 14-17 30537097-1 2019 1alpha,25-Dihydroxyvitamin D3 (also called 1,25(OH)2 D3 or calcitriol) is the biologically active form of vitamin D, which functions as a ligand to the vitamin D receptor (VDR). Vitamin D 19-28 vitamin D receptor Rattus norvegicus 152-170 30537097-1 2019 1alpha,25-Dihydroxyvitamin D3 (also called 1,25(OH)2 D3 or calcitriol) is the biologically active form of vitamin D, which functions as a ligand to the vitamin D receptor (VDR). Vitamin D 19-28 vitamin D receptor Rattus norvegicus 172-175 30889441-5 2019 The 117 genes include two positive controls, Nep and Park7, already known to be affected by both AD and vitamin D hypovitaminosis. Vitamin D 104-113 tensin 2 Mus musculus 45-48 30889441-5 2019 The 117 genes include two positive controls, Nep and Park7, already known to be affected by both AD and vitamin D hypovitaminosis. Vitamin D 104-113 Parkinson disease (autosomal recessive, early onset) 7 Mus musculus 53-58 30795966-8 2019 Logistic regression analysis showed that hypertension (odds ratio [OR] = 5.348, 95% confidence intervals [CI] 1.184-23.350, P = .026), expression of platelet CD62p (OR = 1.095, 95% CI 1.052-1.201, P = .018) and vitamin D level (OR = .832, 95% CI .763-.934, P = .005) were associated with CR in ischemic stroke patients. Vitamin D 211-220 selectin P Homo sapiens 158-163 30157994-0 2019 Therapeutic Efficacy of Vitamin D in Experimental c-MET-beta-Catenin-Driven Hepatocellular Cancer. Vitamin D 24-33 met proto-oncogene Mus musculus 50-55 31040902-0 2019 Are serum leptin levels predicted by lipoproteins, vitamin D and body composition? Vitamin D 51-60 leptin Homo sapiens 10-16 31040902-2 2019 The connection between body composition, Vitamin D and leptin in young adults is important to be studied as body composition may affect bone health and therefore the possibility of osteoporosis in later life. Vitamin D 41-50 leptin Homo sapiens 55-61 31040902-3 2019 Few studies have attempted to investigate the effect of body composition and leptin with vitamin D in adolescence. Vitamin D 89-98 leptin Homo sapiens 77-83 30668811-0 2019 Vitamin D enzymes (CYP27A1, CYP27B1, and CYP24A1) and receptor expression in non-melanoma skin cancer. Vitamin D 0-9 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 19-26 29752008-0 2019 A genetic variant in the cytochrome P450 family 2 subfamily R member 1 determines response to vitamin D supplementation. Vitamin D 94-103 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 25-70 29752008-5 2019 We aimed to explore the association between a potential vitamin D-related polymorphism (the rs10766197 polymorphism in the CYP2R1 gene) with the response to supplementation of vitamin D in 253 healthy Iranian girls. Vitamin D 56-65 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 123-129 29752008-5 2019 We aimed to explore the association between a potential vitamin D-related polymorphism (the rs10766197 polymorphism in the CYP2R1 gene) with the response to supplementation of vitamin D in 253 healthy Iranian girls. Vitamin D 176-185 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 123-129 29752008-14 2019 CONCLUSION: Changes in serum vitamin D and metabolic profile following high dose supplementation with vitamin D were associated with CYP2R1 polymorphism. Vitamin D 29-38 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 133-139 29752008-14 2019 CONCLUSION: Changes in serum vitamin D and metabolic profile following high dose supplementation with vitamin D were associated with CYP2R1 polymorphism. Vitamin D 102-111 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 133-139 30997352-0 2019 Importance of Studying the Levels of Hepcidin and Vitamin D in Egyptian Children with Chronic Hepatitis C. Background and Objective: Hepcidin is the key regulator of iron metabolism and is a significant biomarker for systemic inflammatory states. Vitamin D 50-59 hepcidin antimicrobial peptide Homo sapiens 133-141 30997352-6 2019 Serum hepcidin level showed significant positive correlation with hepcidin expression, HCV titer, iron, ferritin, and H/F ratio (r = 0.43, 0.31, 0.34, 0.28, and 0.91, respectively) but significant negative correlation with vitamin D (r = -0.37). Vitamin D 223-232 hepcidin antimicrobial peptide Homo sapiens 6-14 30893279-9 2021 The significant increase in HSP27 concentration was only noticed in SG with normal vitamin D concentrations. Vitamin D 83-92 heat shock protein family B (small) member 1 Homo sapiens 28-33 30874583-4 2019 In contrast to cultivation in conventional tissue culture settings, on-chip cultivation of HepG2 and RPTEC cells in interconnected chambers, used to mimic the liver and kidneys, respectively, resulted in the enhanced expression of vitamin D metabolizing enzymes (CYP2R1, CYP27B1 and CYP24A1). Vitamin D 231-240 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 263-269 30881343-7 2019 The relationships between the principal adipokines (leptin, adiponectin, resistin) are revealed in the presence of normal vitamin D content and in vitamin D deficiency. Vitamin D 122-131 leptin Homo sapiens 52-58 30881343-7 2019 The relationships between the principal adipokines (leptin, adiponectin, resistin) are revealed in the presence of normal vitamin D content and in vitamin D deficiency. Vitamin D 122-131 resistin Homo sapiens 73-81 30881343-7 2019 The relationships between the principal adipokines (leptin, adiponectin, resistin) are revealed in the presence of normal vitamin D content and in vitamin D deficiency. Vitamin D 147-156 leptin Homo sapiens 52-58 30881343-7 2019 The relationships between the principal adipokines (leptin, adiponectin, resistin) are revealed in the presence of normal vitamin D content and in vitamin D deficiency. Vitamin D 147-156 resistin Homo sapiens 73-81 30616171-3 2019 The treatment with 100 ng/mL vitamin D remarkably reduced the thickness of the airway smooth muscle, collagen deposition, and the alpha-smooth muscle actin (alpha-SMA) mass and airway inflammation. Vitamin D 29-38 actin gamma 2, smooth muscle Rattus norvegicus 157-166 30616171-5 2019 The putative signaling pathway of vitamin D was based on Wnt5a and beta-catenin expression assessed by quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) and Western blot, which revealed that the administration of vitamin D significantly decreased the activity of Wnt/beta-catenin signaling pathway. Vitamin D 34-43 catenin beta 1 Rattus norvegicus 67-79 30616171-5 2019 The putative signaling pathway of vitamin D was based on Wnt5a and beta-catenin expression assessed by quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) and Western blot, which revealed that the administration of vitamin D significantly decreased the activity of Wnt/beta-catenin signaling pathway. Vitamin D 34-43 Wnt family member 2 Rattus norvegicus 57-60 30616171-5 2019 The putative signaling pathway of vitamin D was based on Wnt5a and beta-catenin expression assessed by quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) and Western blot, which revealed that the administration of vitamin D significantly decreased the activity of Wnt/beta-catenin signaling pathway. Vitamin D 34-43 catenin beta 1 Rattus norvegicus 298-310 30616171-5 2019 The putative signaling pathway of vitamin D was based on Wnt5a and beta-catenin expression assessed by quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) and Western blot, which revealed that the administration of vitamin D significantly decreased the activity of Wnt/beta-catenin signaling pathway. Vitamin D 244-253 catenin beta 1 Rattus norvegicus 67-79 30616171-5 2019 The putative signaling pathway of vitamin D was based on Wnt5a and beta-catenin expression assessed by quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) and Western blot, which revealed that the administration of vitamin D significantly decreased the activity of Wnt/beta-catenin signaling pathway. Vitamin D 244-253 Wnt family member 2 Rattus norvegicus 57-60 30616171-5 2019 The putative signaling pathway of vitamin D was based on Wnt5a and beta-catenin expression assessed by quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) and Western blot, which revealed that the administration of vitamin D significantly decreased the activity of Wnt/beta-catenin signaling pathway. Vitamin D 244-253 catenin beta 1 Rattus norvegicus 298-310 30616171-6 2019 These results suggested that administration of vitamin D alleviated the airway remodeling in asthma by down-regulating the activity of Wnt/beta-catenin signaling pathway. Vitamin D 47-56 Wnt family member 2 Rattus norvegicus 135-138 30616171-6 2019 These results suggested that administration of vitamin D alleviated the airway remodeling in asthma by down-regulating the activity of Wnt/beta-catenin signaling pathway. Vitamin D 47-56 catenin beta 1 Rattus norvegicus 139-151 30508644-0 2019 Participation of vitamin D-upregulated protein 1 (TXNIP)-ASK1-JNK1 signalosome in the enhancement of AML cell death by a post-cytotoxic differentiation regimen. Vitamin D 17-26 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 57-61 30791479-5 2019 The vitamin-D analogue, calcipotriol, induced increased expression of the neuronal vitamin D-dependent calcium-binding protein, calbindin-D28k, and this significantly decreased the occurrence of alpha-syn aggregates in cells with transiently raised intracellular free Ca, thereby increasing viability. Vitamin D 4-13 synuclein alpha Homo sapiens 195-204 30777056-0 2019 A genetic variant of CYP2R1 identified in a cat with type 1B vitamin D-dependent rickets: a case report. Vitamin D 61-70 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 21-27 30777056-7 2019 Examination of the DNA sequences of CYP2R1 and CYP27B1 genes, which are genes linked with vitamin D metabolism, showed a CYP2R1 frameshift mutation in exon 5 (where T is deleted at position c.1386). Vitamin D 90-99 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 36-42 30777056-7 2019 Examination of the DNA sequences of CYP2R1 and CYP27B1 genes, which are genes linked with vitamin D metabolism, showed a CYP2R1 frameshift mutation in exon 5 (where T is deleted at position c.1386). Vitamin D 90-99 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 121-127 30777056-10 2019 CONCLUSIONS: To the best of our knowledge, the present case is the first description of type 1B vitamin D-dependent rickets linked with a genetic variant of CYP2R1 in a cat. Vitamin D 96-105 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 157-163 30792871-0 2019 A novel PHEX mutation associated with vitamin D-resistant rickets. Vitamin D 38-47 phosphate regulating endopeptidase homolog X-linked Homo sapiens 8-12 30597484-1 2019 Background: Sodium-glucose cotransporter-2 inhibitors promote glycosuria, resulting in possible effects on calcium, phosphate, and vitamin D homeostasis. Vitamin D 131-140 solute carrier family 5 member 2 Homo sapiens 12-42 30669280-0 2019 The Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United Kingdom. Vitamin D 14-23 hepcidin antimicrobial peptide Homo sapiens 43-51 30246883-7 2019 RESULTS: Vitamin D supplementation resulted in significant increase of serum 25OHD level (P < 0.001), and significant decrease in PTH (P < 0.001), MCP-1 (P < 0.05), IL-1beta (P < 0.05) and TLR-4 (P < 0.05); compared to the baseline values in vitamin D group. Vitamin D 9-18 C-C motif chemokine ligand 2 Homo sapiens 147-152 30246883-7 2019 RESULTS: Vitamin D supplementation resulted in significant increase of serum 25OHD level (P < 0.001), and significant decrease in PTH (P < 0.001), MCP-1 (P < 0.05), IL-1beta (P < 0.05) and TLR-4 (P < 0.05); compared to the baseline values in vitamin D group. Vitamin D 9-18 interleukin 1 alpha Homo sapiens 165-173 30246883-7 2019 RESULTS: Vitamin D supplementation resulted in significant increase of serum 25OHD level (P < 0.001), and significant decrease in PTH (P < 0.001), MCP-1 (P < 0.05), IL-1beta (P < 0.05) and TLR-4 (P < 0.05); compared to the baseline values in vitamin D group. Vitamin D 9-18 toll like receptor 4 Homo sapiens 189-194 30246883-10 2019 CONCLUSIONS: Improvement in vitamin D status in obese subjects with vitamin D deficiency in combination with weight loss diet resulted in weight, fat mass and MCP-1 decrease. Vitamin D 28-37 C-C motif chemokine ligand 2 Homo sapiens 159-164 30246883-10 2019 CONCLUSIONS: Improvement in vitamin D status in obese subjects with vitamin D deficiency in combination with weight loss diet resulted in weight, fat mass and MCP-1 decrease. Vitamin D 68-77 C-C motif chemokine ligand 2 Homo sapiens 159-164 30395535-0 2018 Vitamin D stimulates multiple microRNAs to inhibit CRH and other pro-labor genes in human placenta. Vitamin D 0-9 corticotropin releasing hormone Homo sapiens 51-54 30395535-3 2018 In this study we test the hypothesis that vitamin D could contribute to the prevention of preterm labor by inhibiting CRH and other pro-labor mediators. Vitamin D 42-51 corticotropin releasing hormone Homo sapiens 118-121 30328681-0 2018 Effects of Quercetin Intervention on Cognition Function in APP/PS1 Mice was Affected by Vitamin D Status. Vitamin D 88-97 presenilin 1 Mus musculus 63-66 30487754-3 2018 Therefore, we investigated the direct effects of VD3 at the specific preantral and antral stages of follicular development, and tested the hypothesis that vitamin D receptor (VDR) and enzymes critical for vitamin D biosynthesis are expressed in the primate ovary. Vitamin D 155-164 vitamin D receptor Macaca mulatta 175-178 30019416-1 2018 OBJECTIVE: This study aimed at investigating the association of serum vitamin D (25(OH)D) and anti-Mullerian hormone (AMH) levels in women with polycystic ovary syndrome (PCOS) as well as non-PCOS healthy ovulatory women and the possible confounding effects of adiposity and androgen. Vitamin D 70-79 anti-Mullerian hormone Homo sapiens 118-121 29855033-12 2018 Vitamin D restriction increases inflammation and reduces the expression of IGF-1 in the liver, worsening the fat-induced changing. Vitamin D 0-9 insulin-like growth factor 1 Rattus norvegicus 75-80 28783999-7 2018 IL-2, Ig-A, and Ig-G levels are significant increased in the vitamin D supplementation group compared with the control group (p < .05) (3). Vitamin D 61-70 immunoglobulin heavy variable 4-38-2-like Homo sapiens 6-10 29654274-8 2018 These data suggest that vitamin D holds a key role for the effector functions of MAMs and that vitamin D supplementation in IMiD combination trials could further increase the therapeutic efficacy of anti-CD38 antibodies such as MOR202, which remains to be investigated in clinical studies. Vitamin D 95-104 CD38 molecule Homo sapiens 204-208 30157189-7 2018 Vitamin D also differentially affected PM-stimulated GM-CSF, with suppression in healthy HBECs and enhancement in asthmatic cultures. Vitamin D 0-9 colony stimulating factor 2 Homo sapiens 53-59 30138371-5 2018 RESULTS: We identified three vitamin D associated genes that were differentially expressed between RA and non-RA patients: Growth arrest and DNA-damage-inducible protein 45 alpha (GADD45A) (FC = 1.47; p = 0.006), Nuclear Receptor Co-repressor 1 (NCOR1) (FC = 1,21; p = 0.005) and paraoxonases 2 (PON2) (FC = -1.37; p = 0.01). Vitamin D 29-38 nuclear receptor corepressor 1 Homo sapiens 213-244 30138371-5 2018 RESULTS: We identified three vitamin D associated genes that were differentially expressed between RA and non-RA patients: Growth arrest and DNA-damage-inducible protein 45 alpha (GADD45A) (FC = 1.47; p = 0.006), Nuclear Receptor Co-repressor 1 (NCOR1) (FC = 1,21; p = 0.005) and paraoxonases 2 (PON2) (FC = -1.37; p = 0.01). Vitamin D 29-38 nuclear receptor corepressor 1 Homo sapiens 246-251 30186876-7 2018 These findings suggested that RBP4 could involve in the improvement of diabetic atherosclerosis; vitamin D had the ability to decrease the level of RBP4 and eventually played an important role in preventing atherosclerosis in diabetes. Vitamin D 97-106 retinol binding protein 4 Rattus norvegicus 148-152 29808911-11 2018 Having a previous SCC appeared associated with not being vitamin D deficient (OR = 0.46, 95%CI = 0.20-1.11, P = 0.084). Vitamin D 57-66 serpin family B member 3 Homo sapiens 18-21 29759135-3 2018 It has been shown that both CD21 and CD83 contribute to the resolution of inflammation occurred in MS. CD21 and CD83 have also been ascribed to Epstein Barr virus (EBV) infection (the prime suspect of MS causality) and the levels of vitamin D, respectively. Vitamin D 233-242 CD83 molecule Homo sapiens 112-116 29795199-2 2018 Recently, it has been shown that vitamin D suppresses hepcidin expression. Vitamin D 33-42 hepcidin antimicrobial peptide Homo sapiens 54-62 29795199-3 2018 Our hypothesis was that hepcidin levels inversely correlate with vitamin D levels in anemic children during acute infection. Vitamin D 65-74 hepcidin antimicrobial peptide Homo sapiens 24-32 29947534-0 2018 Vitamin D upregulates endothelin-1, ETBR, eNOS mRNA expression and attenuates vascular remodelling and ischemia in kidney fibrosis model in mice. Vitamin D 0-9 endothelin 1 Mus musculus 22-34 29947534-0 2018 Vitamin D upregulates endothelin-1, ETBR, eNOS mRNA expression and attenuates vascular remodelling and ischemia in kidney fibrosis model in mice. Vitamin D 0-9 endothelin receptor type B Mus musculus 36-40 29947534-0 2018 Vitamin D upregulates endothelin-1, ETBR, eNOS mRNA expression and attenuates vascular remodelling and ischemia in kidney fibrosis model in mice. Vitamin D 0-9 nitric oxide synthase 3, endothelial cell Mus musculus 42-46 29947534-1 2018 We examined the upregulation of ET-1/ETBR/eNOS signaling in renoprotective effect of vitamin D in kidney fibrosis model in mice using unilateral ureteral obstruction (UUO). Vitamin D 85-94 endothelin 1 Mus musculus 32-36 29947534-1 2018 We examined the upregulation of ET-1/ETBR/eNOS signaling in renoprotective effect of vitamin D in kidney fibrosis model in mice using unilateral ureteral obstruction (UUO). Vitamin D 85-94 endothelin receptor type B Mus musculus 37-41 29947534-1 2018 We examined the upregulation of ET-1/ETBR/eNOS signaling in renoprotective effect of vitamin D in kidney fibrosis model in mice using unilateral ureteral obstruction (UUO). Vitamin D 85-94 nitric oxide synthase 3, endothelial cell Mus musculus 42-46 29947534-10 2018 Vitamin D treatment also increased ET-1, ETBR and eNOS mRNA expressions. Vitamin D 0-9 endothelin 1 Mus musculus 35-39 29947534-10 2018 Vitamin D treatment also increased ET-1, ETBR and eNOS mRNA expressions. Vitamin D 0-9 endothelin receptor type B Mus musculus 41-45 29947534-10 2018 Vitamin D treatment also increased ET-1, ETBR and eNOS mRNA expressions. Vitamin D 0-9 nitric oxide synthase 3, endothelial cell Mus musculus 50-54 29947534-13 2018 Vitamin D ameliorates kidney fibrosis through attenuating vascular remodeling and ischemia with upregulating ET-1/ETBR and eNOS expression. Vitamin D 0-9 endothelin 1 Mus musculus 109-113 29947534-13 2018 Vitamin D ameliorates kidney fibrosis through attenuating vascular remodeling and ischemia with upregulating ET-1/ETBR and eNOS expression. Vitamin D 0-9 endothelin receptor type B Mus musculus 114-118 29947534-13 2018 Vitamin D ameliorates kidney fibrosis through attenuating vascular remodeling and ischemia with upregulating ET-1/ETBR and eNOS expression. Vitamin D 0-9 nitric oxide synthase 3, endothelial cell Mus musculus 123-127 29755836-12 2018 CONCLUSIONS: Vitamin D deficiency is associated with the degree of luminal stenosis and burden of CAD in women undergoing coronary angiography. Vitamin D 13-22 aconitate decarboxylase 1 Homo sapiens 98-101 29628342-0 2018 MEG3 Activated by Vitamin D Inhibits Colorectal Cancer Cells Proliferation and Migration via Regulating Clusterin. Vitamin D 18-27 maternally expressed 3 Homo sapiens 0-4 29628342-7 2018 These results suggested that MEG3 functions as a tumor suppressor in CRC via regulating the Clusterin activities and may underlie the anticancer activities of vitamin D on CRC cells. Vitamin D 159-168 maternally expressed 3 Homo sapiens 29-33 29105518-1 2018 The relationship between serum anti-Mullerian hormone (AMH) with vitamin D (25OH-D) and metabolic syndrome (MetS) risk was evaluated in healthy, late reproductive-age (35-49 years) women with regular menstrual cycles. Vitamin D 65-74 anti-Mullerian hormone Homo sapiens 55-58 29229305-3 2018 The regulatory effects of vitamin D on Wnt/beta-catenin pathway were demonstrated by previous studies. Vitamin D 26-35 catenin beta 1 Homo sapiens 43-55 29642181-9 2018 Furthermore, based on the OR values, association of vitamin D insufficiency with disease type, study location, number of patients, and methods for detecting CLA was observed. Vitamin D 52-61 selectin P ligand Homo sapiens 157-160 29533337-0 2018 A Relationship Between Blood Levels of Otolin-1 and Vitamin D. Vitamin D 52-61 otolin 1 Homo sapiens 39-47 29533337-2 2018 Since otoconia degeneration contributes to iBPPV and a lack of vitamin D may impact otoconia structure and integrity, we proposed a negative association between vitamin D levels and levels of a proposed circulatory biomarker for otolithic degeneration, otolin-1. Vitamin D 161-170 otolin 1 Homo sapiens 253-261 29533337-11 2018 There was a negative correlation between vitamin D and otolin-1 levels of subjects over 70 (r = -0.36, p = 0.036). Vitamin D 41-50 otolin 1 Homo sapiens 55-63 29533337-12 2018 CONCLUSION: Our results demonstrate a relationship between vitamin D and otolin-1. Vitamin D 59-68 otolin 1 Homo sapiens 73-81 29470176-3 2018 However, there is a paucity of literature with regard to a relationship between insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3) and vitamin D particularly in subjects with VDD. Vitamin D 177-186 insulin like growth factor binding protein 3 Homo sapiens 118-162 29470176-3 2018 However, there is a paucity of literature with regard to a relationship between insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3) and vitamin D particularly in subjects with VDD. Vitamin D 177-186 insulin like growth factor binding protein 3 Homo sapiens 164-171 29470176-11 2018 The serum IGF-1 and IGFBP-3 levels increased significantly post supplementation with vitamin D. Vitamin D 85-94 insulin like growth factor binding protein 3 Homo sapiens 20-27 29568200-7 2018 In a larger cohort of patients and controls, a disease-associated expression pattern, with higher transcript levels in vitamin D-treated PBMCs from patients, was observed for three of these genes, CLEC5A (P < 0.030), lysozyme (LYZ; P < 0.047) and TREM1 (P < 0.023). Vitamin D 119-128 triggering receptor expressed on myeloid cells 1 Homo sapiens 253-258 28008453-0 2018 Association of VDBP and CYP2R1 gene polymorphisms with vitamin D status in women with polycystic ovarian syndrome: a north Indian study. Vitamin D 55-64 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 24-30 28008453-10 2018 CONCLUSIONS: The present study shows that the GT allele of VDBP SNP rs7041, the VDBP allelic combination (GC1F/1F), and GA allele of CYP2R1 SNP rs2060793 in vitamin D deficient women increase the risk of PCOS. Vitamin D 157-166 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 133-139 29290431-3 2018 In the intracrine vitamin D pathway, pathogen recognition receptors upregulate CYP27B1 mRNA that encodes for the enzyme that converts 25-hydroxyvitamin D [25(OH)D3] to the active vitamin D hormone, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. Vitamin D 18-27 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial Bos taurus 79-86 29290431-3 2018 In the intracrine vitamin D pathway, pathogen recognition receptors upregulate CYP27B1 mRNA that encodes for the enzyme that converts 25-hydroxyvitamin D [25(OH)D3] to the active vitamin D hormone, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. Vitamin D 144-153 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial Bos taurus 79-86 29520786-9 2018 IL-8 and monocyte chemotactic protein-1 mRNA expression could be suppressed by the vitamin D pathway. Vitamin D 83-92 C-C motif chemokine ligand 2 Homo sapiens 9-39 28765037-0 2018 Vitamin D effects on monocytes" CCL-2, IL6 and CD14 transcription in Addison"s disease and HLA susceptibility. Vitamin D 0-9 C-C motif chemokine ligand 2 Homo sapiens 32-37 28765037-8 2018 We found a downregulation of CCL-2 after vitamin D treatment in IL1beta-stimulated monocytes both from AD patients and HC (AD p<0.001; HC p<0.0001). Vitamin D 41-50 C-C motif chemokine ligand 2 Homo sapiens 29-34 28870774-8 2018 In total, VDR sites with GABPA co-localization may control some 450 vitamin D target genes. Vitamin D 68-77 GA binding protein transcription factor subunit alpha Homo sapiens 25-30 29037825-0 2018 Vitamin D prevents lipid accumulation in murine muscle through regulation of PPARgamma and perilipin-2 expression. Vitamin D 0-9 predicted gene 12551 Mus musculus 91-102 29469965-2 2018 Vitamin D influences cellular function by signaling through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Canis lupus familiaris 64-82 29469965-2 2018 Vitamin D influences cellular function by signaling through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Canis lupus familiaris 84-87 29737807-7 2018 Vitamin D was highly correlated with DPN, DN, diabetes duration, age, sex, fasting plasma glucose, blood urea nitrogen, total cholesterol, low density lipoprotein cholesterol, 24-h urinary microalbumin, and beta-2 microglobulin (r=-0.34 ~ -0.133, p<0.05). Vitamin D 0-9 beta-2-microglobulin Homo sapiens 207-227 29138801-2 2018 Calcitriol, a biologically active metabolite of vitamin D, exerts its endocrinological influence via nuclear vitamin D receptor. Vitamin D 48-57 vitamin D receptor Rattus norvegicus 109-127 28433688-0 2018 Vitamin D downregulates the IL-23 receptor pathway in human mucosal group 3 innate lymphoid cells. Vitamin D 0-9 interleukin 23 receptor Homo sapiens 28-42 29504336-0 2018 Vitamin D Deficiency In Pakistan: Tip Of Iceberg. Vitamin D 0-9 TOR signaling pathway regulator Homo sapiens 34-37 29504336-11 2018 CONCLUSIONS: Vitamin D deficiency is affecting the Pakistani population irrespective of age and gender, and the results of this study have demonstrated that vitamin D deficiency in Pakistan is the tip of iceberg.. Vitamin D 157-166 TOR signaling pathway regulator Homo sapiens 197-200 28374624-7 2017 Furthermore, high serum leptin was negatively associated with vitamin D and physical performance. Vitamin D 62-71 leptin Homo sapiens 24-30 28374624-8 2017 CONCLUSIONS: Serum leptin levels were correlated with low vitamin D, reduced muscle strength and functional impairment, suggesting that serum leptin might serve as a biomarker reflecting physical performance in OA patients. Vitamin D 58-67 leptin Homo sapiens 19-25 29208234-8 2017 In other cell types S1PR2 is regulated by vitamin D; here we found that treatment with 1,25(OH)2D3 for 48 or 72 h reduces S1PR2 (4-fold; <0.05), but not R1 and R3, expression. Vitamin D 42-51 sphingosine-1-phosphate receptor 2 Homo sapiens 20-25 29208234-11 2017 Importantly, expression of S1PR2, and therefore S1P function, can be down-regulated by vitamin D. Vitamin D 87-96 sphingosine-1-phosphate receptor 2 Homo sapiens 27-32 29186865-4 2017 The organic anion transporter 1 (OAT-1) overexpressing ciPTEC line presented 1alpha-hydroxylase (CYP27B1), 24-hydroxylase (CYP24A1) and vitamin D receptor (VDR), responsible for vitamin D activation, degradation and function, respectively. Vitamin D 136-145 solute carrier family 22 member 6 Homo sapiens 4-31 29186865-4 2017 The organic anion transporter 1 (OAT-1) overexpressing ciPTEC line presented 1alpha-hydroxylase (CYP27B1), 24-hydroxylase (CYP24A1) and vitamin D receptor (VDR), responsible for vitamin D activation, degradation and function, respectively. Vitamin D 136-145 solute carrier family 22 member 6 Homo sapiens 33-38 27966571-1 2017 We aimed to investigate the potential association between vitamin D and serum leptin levels by pooling together the results from observational studies and clinical trials. Vitamin D 58-67 leptin Homo sapiens 78-84 28674792-7 2017 Adipose tissue MCP-1 concentration also reduced in HFD + vitamin D group compared with HFD group. Vitamin D 57-66 C-C motif chemokine ligand 2 Rattus norvegicus 15-20 27473561-0 2017 CYP2R1 mutations causing vitamin D-deficiency rickets. Vitamin D 25-34 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 0-6 27473561-1 2017 CYP2R1 is the principal hepatic 25-hydroxylase responsible for the hydroxylation of parent vitamin D to 25-hydroxyvitamin D [25(OH)D]. Vitamin D 91-100 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 0-6 27473561-7 2017 We review the evidence that inactivating mutations in CYP2R1 can lead to a novel form of vitamin D-deficiency rickets resulting from impaired 25-hydroxylation of vitamin D. Vitamin D 89-98 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 54-60 27473561-7 2017 We review the evidence that inactivating mutations in CYP2R1 can lead to a novel form of vitamin D-deficiency rickets resulting from impaired 25-hydroxylation of vitamin D. Vitamin D 162-171 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 54-60 27473561-11 2017 In silico analyses predicted impaired CYP2R1 folding or reduced interaction with substrate vitamin D by L99P and K242N mutations, respectively. Vitamin D 91-100 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 38-44 27473561-16 2017 We conclude that mutations in CYP2R1 are responsible for an atypical form of vitamin D-deficiency rickets, which has been classified as vitamin D dependent rickets type 1B (VDDR1B, MIM 600081). Vitamin D 77-86 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 30-36 27473561-16 2017 We conclude that mutations in CYP2R1 are responsible for an atypical form of vitamin D-deficiency rickets, which has been classified as vitamin D dependent rickets type 1B (VDDR1B, MIM 600081). Vitamin D 136-145 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 30-36 27576086-4 2017 The affinities of the synthesized vitamin D analogs to the full-length recombinant rat VDR were examined, as well as their differentiating and transcriptional activities. Vitamin D 34-43 vitamin D receptor Rattus norvegicus 87-90 27923595-10 2017 The vitamin D compounds also down-regulated the Notch signaling molecules, Notch1, Notch2, Notch3, JAG1, JAG2, HES1 and NFkappaB, which are involved in breast cancer stem cell maintenance. Vitamin D 4-13 notch receptor 3 Homo sapiens 91-97 27923595-10 2017 The vitamin D compounds also down-regulated the Notch signaling molecules, Notch1, Notch2, Notch3, JAG1, JAG2, HES1 and NFkappaB, which are involved in breast cancer stem cell maintenance. Vitamin D 4-13 jagged canonical Notch ligand 1 Homo sapiens 99-103 27923595-11 2017 In addition, the vitamin D compounds up-regulated myoepithelial differentiating markers, cytokeratin 14 and smooth muscle actin, and down-regulated the luminal marker, cytokeratin 18. Vitamin D 17-26 keratin 14 Homo sapiens 89-103 27923595-11 2017 In addition, the vitamin D compounds up-regulated myoepithelial differentiating markers, cytokeratin 14 and smooth muscle actin, and down-regulated the luminal marker, cytokeratin 18. Vitamin D 17-26 keratin 18 Homo sapiens 168-182 27923595-12 2017 Cytokeratin 5, a biomarker associated with basal-like breast cancer, was found to be significantly down-regulated by the vitamin D compounds. Vitamin D 121-130 keratin 5 Homo sapiens 0-13 28159673-0 2017 RIPK1 binds to vitamin D receptor and decreases vitamin D-induced growth suppression. Vitamin D 15-24 receptor interacting serine/threonine kinase 1 Homo sapiens 0-5 28922414-2 2017 Vitamin D affects genes regulating proliferation, apoptosis, and differentiation and induces the tumor suppressor 15-hydroxyprostaglandin dehydrogenase (PGDH) in other cancers. Vitamin D 0-9 15-hydroxyprostaglandin dehydrogenase Homo sapiens 153-157 28922414-4 2017 We hypothesized that vitamin D supplementation may have beneficial effects on gene expression including 15-PGDH in BE. Vitamin D 21-30 15-hydroxyprostaglandin dehydrogenase Homo sapiens 107-111 28853522-0 2017 [THE EFFECT OF VITAMIN D ON THE EXPRESSION OF ADAMTS13 IN CULTURED ENDOTHELIAL CELLS EXPOSED TO A DIABETIC-LIKE ENVIRONMENT]. Vitamin D 15-24 ADAM metallopeptidase with thrombospondin type 1 motif 13 Homo sapiens 46-54 28853522-7 2017 This study evaluated the role of vitamin D on ADAMTS13 activity in human umbilical vein endothelial cells (HUVEC) exposed to a diabetic-like environment. Vitamin D 33-42 ADAM metallopeptidase with thrombospondin type 1 motif 13 Homo sapiens 46-54 28853522-13 2017 Normalization of ADAMTS13 by vitamin D may contribute to improvement in hypercoagulability. Vitamin D 29-38 ADAM metallopeptidase with thrombospondin type 1 motif 13 Homo sapiens 17-25 28575224-12 2017 Conclusions: Genetic variation in DHCR7, which encodes 7-dehyrocholesterol reductase in the epidermal vitamin D biosynthesis pathway, appears to modify baseline 25(OH)D. In contrast, the response to antenatal cholecalciferol supplementation was associated with SNPs in CYP2R1, which may alter 25-hydroxylase activity, and GC, which may affect vitamin D binding protein synthesis or metabolite affinity. Vitamin D 102-111 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 269-275 27927883-1 2017 Objectives The aim of this study was to assess the vitamin D status in treatment-naive SLE patients and its association with clinical and laboratory markers of disease activity, including serum levels of IL-17 and IL-23. Vitamin D 51-60 interleukin 23 subunit alpha Homo sapiens 214-219 28509078-10 2017 Compared to baseline, vascular cell adhesion molecule-1 and E-selectin levels decreased significantly in vitamin D treated subjects; however, there were no significant differences between two groups. Vitamin D 105-114 selectin E Homo sapiens 60-70 28370465-6 2017 These findings uncover crosstalk between the BMP-Smad1 and RANKL-NF-kappaB pathways during osteoclastogenesis that underlies the action of active vitamin D on bone health. Vitamin D 146-155 SMAD family member 1 Mus musculus 49-54 28370465-6 2017 These findings uncover crosstalk between the BMP-Smad1 and RANKL-NF-kappaB pathways during osteoclastogenesis that underlies the action of active vitamin D on bone health. Vitamin D 146-155 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 59-64 28384529-0 2017 Vitamin D reduces the inflammatory response by Porphyromonas gingivalis infection by modulating human beta-defensin-3 in human gingival epithelium and periodontal ligament cells. Vitamin D 0-9 defensin beta 103B Homo sapiens 102-117 28384529-8 2017 Our results indicate that vitamin D specifically enhances the production of the human-beta-defensin 3 antimicrobial peptide and exerts an inhibitory effect on the pro-inflammatory cytokines, thus suggesting that vitamin D may offer possible therapeutic applications for periodontitis. Vitamin D 26-35 defensin beta 103B Homo sapiens 86-101 28384529-8 2017 Our results indicate that vitamin D specifically enhances the production of the human-beta-defensin 3 antimicrobial peptide and exerts an inhibitory effect on the pro-inflammatory cytokines, thus suggesting that vitamin D may offer possible therapeutic applications for periodontitis. Vitamin D 212-221 defensin beta 103B Homo sapiens 86-101 27987058-7 2017 Importantly, we also assessed the anti-inflammatory property of vitamin D in the MPTP mouse, in which it upregulated the anti-inflammatory cytokines (IL-10, IL-4 and TGF-beta) mRNA expression as well as increasing the expression of CD163, CD206 and CD204, typical hallmarks of alternative activation of microglia for anti-inflammatory signalling (M2). Vitamin D 64-73 interleukin 4 Mus musculus 157-161 28218743-2 2017 Vitamin D is activated through hydroxylation by 25-hydroxylases (CYP2R1 or CYP27A1) and 1alpha-hydroxylase (CYP27B1) to produce 1,25(OH)2D3, or through the action of CYP11A1 to produce mono-di- and trihydroxy-D3 products that can be further modified by CYP27B1, CYP27A1, and CYP24A1. Vitamin D 0-9 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 65-71 28218743-2 2017 Vitamin D is activated through hydroxylation by 25-hydroxylases (CYP2R1 or CYP27A1) and 1alpha-hydroxylase (CYP27B1) to produce 1,25(OH)2D3, or through the action of CYP11A1 to produce mono-di- and trihydroxy-D3 products that can be further modified by CYP27B1, CYP27A1, and CYP24A1. Vitamin D 0-9 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 75-82 28218743-2 2017 Vitamin D is activated through hydroxylation by 25-hydroxylases (CYP2R1 or CYP27A1) and 1alpha-hydroxylase (CYP27B1) to produce 1,25(OH)2D3, or through the action of CYP11A1 to produce mono-di- and trihydroxy-D3 products that can be further modified by CYP27B1, CYP27A1, and CYP24A1. Vitamin D 0-9 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 262-269 28545072-10 2017 KLF-10 levels tended to be higher in EPCs exposed to vitamin D, with no differences in angiopoietic markers. Vitamin D 53-62 Kruppel like factor 10 Homo sapiens 0-6 27567005-10 2017 The active vitamin D hormone, 1,25(OH)2 D3 likely increased calcification in aortic smooth muscle cells perhaps by directly modulating expression of Alpl, Rankl, and Opg. Vitamin D 11-20 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 155-160 28029182-6 2017 Second, vitamin D-induced aorta vascular calcification rate in Nedd4fl/fl ;SM22alpha-Cre mice was significantly higher than their wild-type littermates. Vitamin D 8-17 transgelin Mus musculus 75-84 28029182-7 2017 Nedd4fl/fl ;SM22alpha-Cre mice showed a development of vascular calcification even at very low-level injection of vitamin D, but this was not exhibited in wild-type littermates. Vitamin D 114-123 transgelin Mus musculus 12-21 28186657-0 2017 Association of Vitamin D Metabolites with Parathyroid Hormone, Fibroblast Growth Factor-23, Calcium, and Phosphorus in Dogs with Various Stages of Chronic Kidney Disease. Vitamin D 15-24 fibroblast growth factor 23 Canis lupus familiaris 63-90 28186657-8 2017 All vitamin D metabolites were negatively correlated with PTH, FGF-23, and phosphorus concentrations (r: -0.39 to -0.64; P < .01). Vitamin D 4-13 fibroblast growth factor 23 Canis lupus familiaris 63-69 28318372-7 2017 ASM/Ht2 were positively associated with vitamin D levels, but negatively associated with white blood cell counts and HOMA-IR by multiple regression analysis. Vitamin D 40-49 H19 imprinted maternally expressed transcript Homo sapiens 0-3 28422993-9 2017 Anti-inflammatory vitamin D interfered with the IL-1beta release and suppressed caspase-5 in keratinocytes and in psoriatic skin lesions. Vitamin D 18-27 caspase 5 Homo sapiens 80-89 28415985-5 2017 Patients were genotyped for functional variants on vitamin D synthetic pathway including GC (rs4588, rs7041, rs22020, rs2282679), CYP2R1 (rs2060793, rs12794714), CYP27B1 (rs10877012), and DHCR7 (rs12785878). Vitamin D 51-60 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 130-136 28120456-7 2017 Because vitamin D-induced hypercalcaemia increases the renal expression of endothelin (ET)-1, we hypothesized that ET-1 mediates the effects of hypercalcaemia on renal sodium and water handling. Vitamin D 8-17 endothelin 1 Mus musculus 75-92 28412753-9 2017 RESULTS: PD-1 expression upon T cell stimulation was increased in CD4+CD25+int T cells in vitamin D treated CD patients from 19% (range 10 - 39%) to 29% (11 - 79%)(p = 0.03) compared with placebo-treated patients. Vitamin D 90-99 interleukin 2 receptor subunit alpha Sus scrofa 70-74 28376103-0 2017 Correction of vitamin D deficiency facilitated suppression of IP-10 and DPP IV levels in patients with chronic hepatitis C: A randomised double-blinded, placebo-control trial. Vitamin D 14-23 dipeptidyl peptidase 4 Homo sapiens 72-78 28376103-7 2017 We hypothesized that correction of vitamin D insufficiency or deficiency in CHC patients might restore immune dysregulation through a pathway linked to the TH1/Th2 cytokines, IP-10 or DPP IV. Vitamin D 35-44 dipeptidyl peptidase 4 Homo sapiens 184-190 28376103-13 2017 Our important finding revealed that upon correction of vitamin D insufficiency or deficiency, the serum IP-10 and DPP IV levels were decreased significantly as compare to the placebo group (delta changes; 83.27 vs -133.80; 95% CI [-326.910, -40.758], p = 0.0125, and 271.04 vs -518.69; 95% CI [-1179,15, -59.781], p = 0.0305, respectively. Vitamin D 55-64 dipeptidyl peptidase 4 Homo sapiens 114-120 28377587-5 2017 Furthermore, we discovered that the mediation of vitamin D on GSN might occur through the vitamin D receptor (VDR) by using gene interruption and overexpression to regulate the level of VDR in PC12 cells (a rat sympathetic nerve cell line). Vitamin D 49-58 vitamin D receptor Rattus norvegicus 90-108 28377587-5 2017 Furthermore, we discovered that the mediation of vitamin D on GSN might occur through the vitamin D receptor (VDR) by using gene interruption and overexpression to regulate the level of VDR in PC12 cells (a rat sympathetic nerve cell line). Vitamin D 49-58 vitamin D receptor Rattus norvegicus 110-113 28377587-5 2017 Furthermore, we discovered that the mediation of vitamin D on GSN might occur through the vitamin D receptor (VDR) by using gene interruption and overexpression to regulate the level of VDR in PC12 cells (a rat sympathetic nerve cell line). Vitamin D 49-58 vitamin D receptor Rattus norvegicus 186-189 28303937-0 2017 Vitamin D inhibits lymphangiogenesis through VDR-dependent mechanisms. Vitamin D 0-9 vitamin D receptor Rattus norvegicus 45-48 28296915-0 2017 Genetic variation in the vitamin D pathway CYP2R1 gene predicts sustained HBeAg seroconversion in chronic hepatitis B patients treated with pegylated interferon: A multicenter study. Vitamin D 25-34 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 43-49 28296915-11 2017 This study provides evidence that not only vitamin D level but also genetic variation of CYP2R1 in the vitamin D cascade influences host immune response in chronic HBV infection. Vitamin D 103-112 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 89-95 28123720-13 2017 However, in vitamin D-treated mice, the thymus indexes, the ratios of CD4+/CD8+, secretion of IL-2 and the proliferation index of spleen T lymphocytes were significantly increased (P<0.05). Vitamin D 12-21 interleukin 2 Mus musculus 94-98 28123720-15 2017 These results indicate that vitamin D supplementation can improve immune recovery in immunosuppressant mice by stimulating T-cell proliferation and elevating IL-2 production. Vitamin D 28-37 interleukin 2 Mus musculus 158-162 29074823-4 2017 The D2 and D3, which are called native vitamin D, are hydroxylated at C25 in the liver by CYP2R1 and then at C1 in the kidney by CYP27B1, to be converted to an active vitamin D metabolite, 1,25-dihydroxyvitamin D[1,25(OH)2D]. Vitamin D 39-48 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 90-96 29074823-4 2017 The D2 and D3, which are called native vitamin D, are hydroxylated at C25 in the liver by CYP2R1 and then at C1 in the kidney by CYP27B1, to be converted to an active vitamin D metabolite, 1,25-dihydroxyvitamin D[1,25(OH)2D]. Vitamin D 167-176 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 90-96 27727459-8 2016 In agreement with the proteomics findings, ELISA measurements showed vitamin K-dependent protein C, von Willebrand factor, fibrinogen gamma chain and multimerin-1 proteins, of relevance to blood coagulation, to be differentially affected (P-value <= 0 05) between sexes after vitamin D status correction. Vitamin D 279-288 protein C, inactivator of coagulation factors Va and VIIIa Homo sapiens 69-162 27813049-1 2016 The aim of this study was to map the genetic expression of the vitamin D metabolizing enzymes CYP27A, CYP27B1, CYP2R1, and CYP24A1 in the first trimester in different human fetal tissues. Vitamin D 63-72 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 111-117 27813049-8 2016 Carriers of the G-allele of the rs2060793 SNP in the CYP2R1 gene, a genotype previously associated with rickets, had lower levels of CYP2R1 mRNA.In conclusion, this study suggest that the kidneys rather than the liver, may be of importance for fetal vitamin D metabolism, even for the 25-hydroxylation, during the first trimester. Vitamin D 250-259 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 53-59 27813049-8 2016 Carriers of the G-allele of the rs2060793 SNP in the CYP2R1 gene, a genotype previously associated with rickets, had lower levels of CYP2R1 mRNA.In conclusion, this study suggest that the kidneys rather than the liver, may be of importance for fetal vitamin D metabolism, even for the 25-hydroxylation, during the first trimester. Vitamin D 250-259 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 133-139 27097322-6 2016 Athletes who had lower vitamin D status had reduced performance scores (p < .01) with odds ratios of 0.85 on the Vertical Jump Test, 0.82 on the Shuttle Run Test, 0.28 on the Triple Hop for Distance Test, and 0.23 on the 1 RM Squat Test. Vitamin D 23-32 HOP homeobox Homo sapiens 185-188 27357175-9 2016 In confounder-adjusted analyses (age, height, lean mass, fat mass, menopause, smoking, estrogen replacement, calcium/vitamin D supplementation, and education) TB and hip BMD were both positively associated with cIMT (0.071 [0.030, 0.112], p = 0.001; 0.063 [0.025, 0.101], p = 0.001, respectively). Vitamin D 117-126 CIMT Homo sapiens 211-215 27237933-12 2016 A total of 176 (86%) of the study population was deficient in vitamin D, according to a level <30 ng mL-1 . Vitamin D 62-71 L1 cell adhesion molecule Mus musculus 104-108 26319202-2 2016 However, different vitamin D metabolites have been shown to increase expression of P-glycoprotein (P-gp, MDR1, ABCB1) and cytochrome P450 3A (CYP3A) in rodents as well as in cell culture systems. Vitamin D 19-28 multidrug resistance protein 1 Ovis aries 83-97 26429395-2 2016 Since adipocytes express VDR and obesity is a known risk factor for cancer, vitamin D actions in adipose tissue may contribute to its cancer protective effects. Vitamin D 76-85 WD and tetratricopeptide repeats 1 Mus musculus 97-104 27783938-0 2016 Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1. Vitamin D 0-9 X-box binding protein 1 Homo sapiens 109-114 27716192-0 2016 Sequence analysis of four vitamin D family genes (VDR, CYP24A1, CYP27B1 and CYP2R1) in Vogt-Koyanagi-Harada (VKH) patients: identification of a potentially pathogenic variant in CYP2R1. Vitamin D 26-35 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 76-82 27716192-0 2016 Sequence analysis of four vitamin D family genes (VDR, CYP24A1, CYP27B1 and CYP2R1) in Vogt-Koyanagi-Harada (VKH) patients: identification of a potentially pathogenic variant in CYP2R1. Vitamin D 26-35 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 178-184 27716192-13 2016 CONCLUSIONS: Screening of four Vitamin D pathway genes in 39 VKH patients shows that a potentially pathogenic sequence variant in CYP2R1 may cause VKH in a subset of patients. Vitamin D 31-40 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 130-136 27379733-0 2016 Dipeptidyl peptidase-4 inhibitors and bone metabolism: is vitamin D the link? Vitamin D 58-67 dipeptidyl peptidase 4 Homo sapiens 0-22 27379733-3 2016 Aim of this study investigated the relationship between treatment with DPP4-Is and vitamin D balance in patients with type 2 diabetes. Vitamin D 83-92 dipeptidyl peptidase 4 Homo sapiens 71-75 27379733-9 2016 CONCLUSIONS: DPP4-Is treatment is associated with improved vitamin D balance in people with type 2 diabetes; our findings suggest that vitamin D may underlie the link between DPP4-Is and bone metabolism. Vitamin D 59-68 dipeptidyl peptidase 4 Homo sapiens 13-17 27379733-9 2016 CONCLUSIONS: DPP4-Is treatment is associated with improved vitamin D balance in people with type 2 diabetes; our findings suggest that vitamin D may underlie the link between DPP4-Is and bone metabolism. Vitamin D 135-144 dipeptidyl peptidase 4 Homo sapiens 175-179 26303194-11 2016 Associations with PC2, a pattern driven by many micro-nutrients, and with PC3, a pattern driven by vitamin D, were less consistent and/or non-significant. Vitamin D 99-108 proprotein convertase subtilisin/kexin type 1 Homo sapiens 74-77 27504197-10 2016 In diabetic groups; serum vitamin D was found to be correlated negatively with serum glucose, insulin, HOMA, cholesterol, triglycerides, and LDL and positively correlated with HDL and tissue VDR. Vitamin D 26-35 vitamin D receptor Rattus norvegicus 191-194 27790417-12 2016 CONCLUSION: The results showed that intake of calcium and vitamin D and estrogen at determined dose led to an increase in OPG and RANKL cytokines reduction which ultimately led to an increase in bone mineral density. Vitamin D 58-67 TNF receptor superfamily member 11B Rattus norvegicus 122-125 27037788-12 2016 Vitamin D insufficiency (25OHD <=20 ng mL(-1) ) was associated with global cognitive impairment (OR 1.56, P = 0.028). Vitamin D 0-9 L1 cell adhesion molecule Mus musculus 42-48 27374117-8 2016 Furthermore, vitamin D deficiency caused upregulation of the mRNA expression of tumor necrosis factor-alpha, hypoxia-inducible factor-1alpha and its downstream target lysyl oxidase in mesenteric PVAT. Vitamin D 13-22 hypoxia inducible factor 1, alpha subunit Mus musculus 109-140 27430408-8 2016 Furthermore, vitamin D increased the mRNA expression levels of LC3 and Beclin 1, and increased Bcl-2 protein expression levels in STZ-treated MIN6 cells, while decreasing the apoptosis rate. Vitamin D 13-22 microtubule-associated protein 1 light chain 3 alpha Mus musculus 63-66 27430408-8 2016 Furthermore, vitamin D increased the mRNA expression levels of LC3 and Beclin 1, and increased Bcl-2 protein expression levels in STZ-treated MIN6 cells, while decreasing the apoptosis rate. Vitamin D 13-22 beclin 1, autophagy related Mus musculus 71-79 27570856-8 2016 The CYP2R1 rs10741657 gene showed that AG and GG allele carriers had significant risk of vitamin D deficiency. Vitamin D 89-98 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 4-10 27570856-11 2016 CONCLUSION: The presence of GG allele of the SNP rs2228570 of VDR gene, SNPs rs4588 of GC gene and CYP2R1 rs10741657 gene was associated with vitamin D deficiency. Vitamin D 142-151 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 99-105 27557122-2 2016 However, epidemiologic studies on orally taken vitamin D and risk of skin cancer (basal cell carcinoma [BCC], squamous cell carcinoma [SCC], and melanoma) are few. Vitamin D 47-56 serpin family B member 3 Homo sapiens 135-138 27377727-4 2016 This regulatory role of vitamin D is supported by both Klotho and Nrf2. Vitamin D 24-33 Klotho Rattus norvegicus 55-61 27377727-5 2016 A decline in the vitamin D/Klotho/Nrf2 regulatory network may enhance the ageing process, and this is well illustrated by the age-related decline in cognition in rats that can be reversed by administering vitamin D. Vitamin D 17-26 Klotho Rattus norvegicus 27-33 27377727-5 2016 A decline in the vitamin D/Klotho/Nrf2 regulatory network may enhance the ageing process, and this is well illustrated by the age-related decline in cognition in rats that can be reversed by administering vitamin D. Vitamin D 205-214 Klotho Rattus norvegicus 27-33 25601896-3 2016 Hence, this study was designed to examine whether the administration of vitamin D can influence the plasma level of P-selectin in patients with VTE. Vitamin D 72-81 selectin P Homo sapiens 116-126 25601896-6 2016 The plasma level of P-selectin (95% confidence interval = -5.99 to -1.63, P = .022) and hs-CRP (P = .024) significantly declined in vitamin D-treated group, while only hs-CRP was significantly decreased in the control group (P = .011). Vitamin D 132-141 selectin P Homo sapiens 20-30 27437780-0 2016 Evaluation of the Relation between Vitamin D and Serum Omentin and Vaspin Levels in Women. Vitamin D 35-44 intelectin 1 Homo sapiens 55-62 27437780-3 2016 The aim of the present study is to investigate how vitamin D levels affect serum vaspin and omentin levels. Vitamin D 51-60 intelectin 1 Homo sapiens 92-99 26994969-5 2016 Ha1 expression is lost during catagen in all mice but recovers more slowly in the knockout pups on the vitamin D-deficient, low-calcium diet. Vitamin D 103-112 keratin 31 Mus musculus 0-3 27399065-9 2016 Levels of cytochrome P450 (CYP) 27A1 were significantly decreased, whereas levels of CYP24A1 were significantly elevated in cirrhotic patients.These results suggest that decreasing vitamin D levels are likely to be a result, rather than a cause, of liver dysfunction and irrespective of HBV viral load. Vitamin D 181-190 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 10-36 27424705-3 2016 Very few case reports in the literature support Vitamin D deficiency as a cause of proximal RTA. Vitamin D 48-57 MAS related GPR family member F Homo sapiens 92-95 27424705-4 2016 We present a case of a young female who presented with proximal RTA and Fanconi syndrome and excellently responded to Vitamin D replacement. Vitamin D 118-127 MAS related GPR family member F Homo sapiens 64-67 27314336-7 2016 Furthermore, our study confirms a deregulation of the vitamin D system: among the transcription factors that potentially regulate the deregulated genes, we find TCF3 and SP1 that are both involved in vitamin D3-induced p27Kip1 expression. Vitamin D 54-63 cyclin dependent kinase inhibitor 1B Homo sapiens 219-226 27203211-7 2016 Serum 25(OH)D was inversely associated with LPS-stimulated VDR expression and with baseline or vitamin D-induced TREM-1 expression, adjusting for age, self-rated health, and functional status. Vitamin D 95-104 triggering receptor expressed on myeloid cells 1 Homo sapiens 113-119 27184385-8 2016 Critically, knockdown of SLC20A2 gene and protein with CRISPR technology in SaOs2 cells significantly ablated vitamin D mediated inhibition of calcification. Vitamin D 110-119 solute carrier family 20 member 2 Homo sapiens 25-32 27184385-10 2016 It also suggests that vitamin D might be used to regulate SLC20A2 gene expression, as well as reduce brain calcification which occurs in Fahr"s disease and normal aging. Vitamin D 22-31 solute carrier family 20 member 2 Homo sapiens 58-65 26190642-3 2016 Vitamin D additionally impacts ALS through cell-signalling mechanisms: glutamate, matrix metalloproteinases, the Wnt/beta-catenin signalling pathway, mitogen-activated protein kinase pathways, prostaglandins, reactive oxygen species and nitric oxide synthase, but its role has been only poorly investigated. Vitamin D 0-9 catenin beta 1 Homo sapiens 117-129 26817629-7 2016 Beneficial actions of treatments with vitamin D or calcitriol on BCa and surrounding adipose tissue included repressed Esr1, aromatase, and Cox2 expression; decreased tumor-derived estrogen and PGE2; reduced expression of leptin receptors; and increased adiponectin receptors. Vitamin D 38-47 estrogen receptor 1 (alpha) Mus musculus 119-123 26778336-9 2016 CONCLUSION: We propose that in obese rat adipocytes, 1,25(OH)2 D down-regulates VDR, resulting in vitamin D resistance, characterized by higher Cyp27b1/1alpha-Hydroxylase and adipogenesis. Vitamin D 98-107 vitamin D receptor Rattus norvegicus 80-83 27003919-0 2016 Identification of Regulatory Mutations in SERPINC1 Affecting Vitamin D Response Elements Associated with Antithrombin Deficiency. Vitamin D 61-70 serpin family C member 1 Homo sapiens 42-50 27003919-7 2016 The relevance of the vitamin D pathway on the regulation of SERPINC1 was confirmed in a cell model. Vitamin D 21-30 serpin family C member 1 Homo sapiens 60-68 27003919-8 2016 Incubation of HepG2 with paricalcitol, a vitamin D analog, increased dose-dependently the levels of SERPINC1transcripts and antithrombin released to the conditioned medium. Vitamin D 41-50 serpin family C member 1 Homo sapiens 100-108 27003919-9 2016 This study shows further evidence of the transcriptional regulation of SERPINC1 by vitamin D and first describes the functional and pathological relevance of mutations affecting VDRE of this gene. Vitamin D 83-92 serpin family C member 1 Homo sapiens 71-79 26462119-11 2016 The novel findings provide the conceptual support that persistent FOXO1 activation may be responsible for insulin resistance and impaired glucose metabolism in vitamin D signaling-deficient mice, as well as evidence for the utility of vitamin D supplementation for intervention in DM2. Vitamin D 160-169 forkhead box O1 Mus musculus 66-71 26911666-8 2016 CONCLUSION: Vitamin D related (VDR rs2228570 and CYP2R1 rs10741657) and IL28B rs12979860 genes polymorphisms accurately assure SVR in naive CHC G4 patients treated with low cost standard therapy. Vitamin D 12-21 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 49-55 26901218-8 2016 Thus, genes controlling the turnover of vitamin D (CYP27B1, CYP24A1), vitamin A (ALDH1A3, AKR1B10), and cholesterol (CYP7B1), were up-regulated in psoriasis, whereas melanomas showed downregulation of genes regulating turnover of vitamin A (AKR1C3), and cholesterol (CYP39A1). Vitamin D 40-49 aldehyde dehydrogenase 1 family member A3 Homo sapiens 81-88 27904547-0 2016 The effect of vitamin D administration on serum leptin and adiponectin levels in end-stage renal disease patients on hemodialysis with vitamin D deficiency: A placebo-controlled double-blind clinical trial. Vitamin D 14-23 leptin Homo sapiens 48-54 27904547-4 2016 The goal of this study was to find the effect of vitamin D administration on serum levels of leptin and adiponectin in ESRD patients. Vitamin D 49-58 leptin Homo sapiens 93-99 27904547-11 2016 This study showed that vitamin D administration is associated with an increase in adiponectin and a decrease in leptin level in ESRD patients. Vitamin D 23-32 leptin Homo sapiens 112-118 25777538-12 2016 In healthy colon of mice fed with high vitamin D diet, the mRNA levels of Wnt5a and ROR2, that promote degradation of beta-catenin, were upregulated whereas beta-catenin and TCF4 protein expression were decreased. Vitamin D 39-48 transcription factor 4 Mus musculus 174-178 26719974-6 2015 Four of these candidate variants (one each in CXXC1 and RUNX2 and two in LRP5) had a >70% derived allele frequency in East Asians, but were present at lower (20-60%) frequency in Europeans as well, suggesting that the adaptation might have been part of a common response to climatic and dietary changes as humans expanded out of Africa, with implications for their role in vitamin D-dependent bone mineralization and osteoporosis insurgence. Vitamin D 376-385 CXXC finger protein 1 Homo sapiens 46-51 24997582-0 2015 Vitamin D and melatonin protect the cell"s viability and ameliorate the CCl4 induced cytotoxicity in HepG2 and Hep3B hepatoma cell lines. Vitamin D 0-9 C-C motif chemokine ligand 4 Homo sapiens 72-76 24997582-4 2015 This study was planned to evaluate antioxidant and cytoprotective activity of melatonin and Vitamin D in CCl4 induced cytotoxicity in HepG2 and Hep3B hepatoma cell lines. Vitamin D 92-101 C-C motif chemokine ligand 4 Homo sapiens 105-109 24997582-5 2015 Based on the cytotoxicity assay, melatonin and Vitamin D were evaluated for cytotoprotective potential against CCl4 induced toxicity in HepG2 and Hep3B liver cell lines by monitoring cell viability, LPO and glutathione (GSH) level. Vitamin D 47-56 C-C motif chemokine ligand 4 Homo sapiens 111-115 24997582-9 2015 As a result, both melatonin and Vitamin D administration during CCl4 exposure protected liver cells from CCl4 induced cell damage. Vitamin D 32-41 C-C motif chemokine ligand 4 Homo sapiens 64-68 24997582-9 2015 As a result, both melatonin and Vitamin D administration during CCl4 exposure protected liver cells from CCl4 induced cell damage. Vitamin D 32-41 C-C motif chemokine ligand 4 Homo sapiens 105-109 26251265-2 2015 Active vitamin D (1alpha,25-dihydroxyvitamin D3; 1,25(OH)2 D3) up-regulates CD4(+) T-cell expression of the purine ectonucleotidase CD39, a molecule that is associated with the generation of anti-inflammatory adenosine. Vitamin D 7-16 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 132-136 26949498-10 2015 Vitamin D up-regulated the expression levels of Bcl-2 by (18.87 fold increase), and down-regulated expression of Bax (23%) and FasL (25%). Vitamin D 0-9 Fas ligand Homo sapiens 127-131 26255277-7 2015 Furthermore, preliminary investigation of vitamin D"s contribution to beta-defensin expression in vivo revealed that intramammary 1,25D treatment of lactating cows increased BNBD7 expression in mammary macrophages. Vitamin D 42-51 beta-defensin 7 Bos taurus 174-179 26224368-3 2015 Among Wnt inhibitors with suitable in vivo biologic activity is vitamin D, which is known to antagonize Wnt/beta-catenin signaling in colorectal cancer and have antitumor activity in PDAC. Vitamin D 64-73 catenin beta 1 Homo sapiens 108-120 26224368-10 2015 IMPLICATIONS: This study provides a novel biochemical target through which vitamin D signaling exerts inhibitory effects on Wnt/beta-catenin signaling, as well as potential biomarkers for predicting and following tumor response to vitamin D-based therapy. Vitamin D 75-84 catenin beta 1 Homo sapiens 128-140 26224368-10 2015 IMPLICATIONS: This study provides a novel biochemical target through which vitamin D signaling exerts inhibitory effects on Wnt/beta-catenin signaling, as well as potential biomarkers for predicting and following tumor response to vitamin D-based therapy. Vitamin D 231-240 catenin beta 1 Homo sapiens 128-140 25724814-1 2015 BACKGROUND: A recent study in children demonstrated that the rs9939609 single-nucleotide polymorphism in the fat mass and obesity (FTO) gene influences prospective weight gain, however, only in those who were vitamin D-deficient. Vitamin D 209-218 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 131-134 25724814-12 2015 CONCLUSIONS: Our data suggest that presurgery vitamin D levels influence the size of genotype effects of FTO rs9939609 on RYGB surgery-induced weight loss in obese patients. Vitamin D 46-55 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 105-108 26298324-0 2015 Vitamin D and estrogen synergy in Vdr-expressing CD4(+) T cells is essential to induce Helios(+)FoxP3(+) T cells and prevent autoimmune demyelinating disease. Vitamin D 0-9 forkhead box P3 Mus musculus 96-101 26202912-1 2015 STUDY QUESTION: Is there a relationship between serum anti-Mullerian hormone (AMH) levels and seasonal variations in serum vitamin D in ovulatory and polycystic ovary syndrome (PCOS) women? Vitamin D 123-132 anti-Mullerian hormone Homo sapiens 78-81 26202912-5 2015 Studies suggest that vitamin D has the ability to modify AMH production in vitro, yet only one clinical study reports the influence of vitamin D on AMH levels. Vitamin D 21-30 anti-Mullerian hormone Homo sapiens 57-60 26202912-5 2015 Studies suggest that vitamin D has the ability to modify AMH production in vitro, yet only one clinical study reports the influence of vitamin D on AMH levels. Vitamin D 135-144 anti-Mullerian hormone Homo sapiens 148-151 26202912-14 2015 While we acknowledge that a longitudinal study monitoring the relationship between serum AMH and vitamin D in individuals over the four seasons would have been ideal, we believe the current findings are robust as our four seasonal groups did not differ for any significant co-variant for serum AMH or vitamin D (age, BMI, PCOS status or AFC) and that there is no significant association between serum vitamin D concentration and AMH production. Vitamin D 97-106 anti-Mullerian hormone Homo sapiens 89-92 26111345-6 2015 We also found a vitamin D response element in Dicer promoter that interacts in vitro to vitamin D and retinoid X receptors. Vitamin D 16-25 dicer 1, ribonuclease III Homo sapiens 46-51 26111345-6 2015 We also found a vitamin D response element in Dicer promoter that interacts in vitro to vitamin D and retinoid X receptors. Vitamin D 88-97 dicer 1, ribonuclease III Homo sapiens 46-51 26111345-9 2015 In summary, the data indicate that in SiHa cells, calcitriol stimulates the expression of Dicer possibly through the vitamin D response element located in its promoter. Vitamin D 117-126 dicer 1, ribonuclease III Homo sapiens 90-95 26037400-0 2015 Vitamin D levels in multiple sclerosis patients: Association with TGF-beta2, TGF-betaRI, and TGF-betaRII expression. Vitamin D 0-9 transforming growth factor beta receptor 1 Homo sapiens 77-87 26169781-0 2015 Maternal vitamin D supplementation during pregnancy and lactation to promote infant growth in Dhaka, Bangladesh (MDIG trial): study protocol for a randomized controlled trial. Vitamin D 9-18 ribosomal oxygenase 2 Homo sapiens 113-117 26180726-10 2015 Additionally, vitamin D may exert an antifibrotic effect partially mediated by MMPs. Vitamin D 14-23 matrix metallopeptidase 1 Homo sapiens 79-83 26149120-0 2015 Vitamin D Deficiency in Uygurs and Kazaks Is Associated with Polymorphisms in CYP2R1 and DHCR7/NADSYN1 Genes. Vitamin D 0-9 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 78-84 26149120-11 2015 CYP2R1-rs10766197 was significantly associated with the presence of vitamin D deficiency in the Uygur ethnic population (P=0.019, OR=6.533, 95%C.I. Vitamin D 68-77 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 0-6 26149120-16 2015 Polymorphisms in CYP2R1-rs10766197 and DHCR7/NADSYN1-rs12785878 are associated with vitamin D deficiency in Uygur and Kazak ethnic populations. Vitamin D 84-93 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 17-23 26107738-4 2015 Here, we report that vitamin D treatment during differentiation of monocytes into DCs markedly enhanced their ability to secrete TNF-alpha, IL-6, IL-1beta and IL-23. Vitamin D 21-30 interleukin 23 subunit alpha Homo sapiens 159-164 26107738-6 2015 Finally, we found that the differentiation of IL-22-producing T cells mediated by supernatants of vitamin D-treated DCs was dependent on TNF-alpha IL-6 and IL-23. Vitamin D 98-107 interleukin 23 subunit alpha Homo sapiens 156-161 25870995-6 2015 The most striking change was in HIV+ HAART+ patients, where increased frequencies of antigen-specific T cells expressing macrophage inflammatory protein (MIP)-1beta - an important anti-HIV blocking chemokine - were observed, with a concomitant increase in plasma MIP-1beta, both of which correlated significantly with vitamin D levels. Vitamin D 318-327 C-C motif chemokine ligand 4 Homo sapiens 121-164 26090872-2 2015 Our objective was to determine whether vitamin D deficiency in older adults is associated with reduced thickness of the ganglion cell complex (GCC) and of the retinal nerve fibre layer (RNFL), as measured with high-definition optical coherence tomography (HD-OCT). Vitamin D 39-48 plexin A2 Homo sapiens 259-262 25823473-7 2015 Treatment of these professional antigen-presenting cells with vitamin D, a key protective environmental factor in multiple sclerosis, downmodulated CLEC16A in parallel with human leukocyte antigen class II. Vitamin D 62-71 C-type lectin domain containing 16A Homo sapiens 148-155 25965341-2 2015 Considering the tolerogenic effects of active vitamin D, we evaluated the therapeutic effect of myelin oligodendrocyte glycoprotein (MOG) associated with active vitamin D in EAE development. Vitamin D 161-170 myelin oligodendrocyte glycoprotein Mus musculus 96-131 25965341-2 2015 Considering the tolerogenic effects of active vitamin D, we evaluated the therapeutic effect of myelin oligodendrocyte glycoprotein (MOG) associated with active vitamin D in EAE development. Vitamin D 161-170 myelin oligodendrocyte glycoprotein Mus musculus 133-136 26046091-4 2015 Utilizing latent TB infection (LTBI) as a surrogate of protection, they identified IL-32 as a mediator of interferon gamma (IFNgamma)-vitamin D dependent antimicrobial immunity and a marker of LTBI. Vitamin D 134-143 interleukin 32 Homo sapiens 83-88 25604607-3 2015 FGF19 regulates bile acid biosynthesis in the bile duct, glucose metabolism and vitamin D and phosphate homeostasis, raises the metabolic rate, reduces body weight, and ameliorates diabetes in mice. Vitamin D 80-89 fibroblast growth factor 15 Mus musculus 0-5 25912039-3 2015 The in vivo effects of vitamin D on murine T cells include inhibition of T cell proliferation, inhibition of IFN-gamma, IL-17 and induction of IL-4. Vitamin D 23-32 interleukin 4 Mus musculus 143-147 25912039-9 2015 Together the data support the late effects of vitamin D on diseases like inflammatory bowel disease and multiple sclerosis where reducing IL-17 and IFN-gamma, while inducing IL-4 and IL-10, would be beneficial. Vitamin D 46-55 interleukin 4 Mus musculus 174-178 26413189-0 2015 A vitamin D analog inhibits Th2 cytokine- and TGFbeta -induced periostin production in fibroblasts: a potential role for vitamin D in skin sclerosis. Vitamin D 2-11 heart and neural crest derivatives expressed 2 Mus musculus 28-31 26413189-11 2015 In addition to the previously reported immunosuppressive effect, the vitamin D analog OCT might be effective to treat scleroderma, in part through inhibition of Th2 cytokine- and TGFbeta-induced POSTN expression. Vitamin D 69-78 heart and neural crest derivatives expressed 2 Mus musculus 161-164 25448751-14 2015 Vitamin D regulating enzymes (CYP24A1, CYP2R1 and CYP27B1) expression were also altered in women with 25(OH)D3 deficiency. Vitamin D 0-9 cytochrome P450 family 2 subfamily R member 1 Homo sapiens 39-45 25713710-7 2015 Moreover, median values of waist circumference, BMI, serum leptin and parathyroid hormone levels were significantly higher in the group with vitamin D deficiency. Vitamin D 141-150 leptin Homo sapiens 59-65 26064917-1 2015 OBJECTIVE: This study was designed to evaluate vitamin D status with separate determination of 25-OH D2 and 25-OH D3 and its relationship to vitamin D binding protein (VDBP) in patients with chronic kidney disease (CKD) and long-term haemodialysis patients (HD). Vitamin D 47-56 GC vitamin D binding protein Homo sapiens 141-166 26064917-1 2015 OBJECTIVE: This study was designed to evaluate vitamin D status with separate determination of 25-OH D2 and 25-OH D3 and its relationship to vitamin D binding protein (VDBP) in patients with chronic kidney disease (CKD) and long-term haemodialysis patients (HD). Vitamin D 47-56 GC vitamin D binding protein Homo sapiens 168-172 25355154-3 2014 Although major targets of vitamin D action are skeletal system and mineral metabolism, vitamin D receptor is ubiquitously expressed in many tissues. Vitamin D 26-35 vitamin D receptor Homo sapiens 87-105 25137505-1 2014 PURPOSE OF REVIEW: To highlight recently published data about the vitamin D status of athletes, and effect of vitamin D supplementation on muscle strength and performance in the athletic population.The vitamin D receptor exists in skeletal muscle, and muscle weakness has been reported in individuals who are severely deficient [25(OH)D <25 nmol/l]. Vitamin D 66-75 vitamin D receptor Homo sapiens 202-220 25137505-1 2014 PURPOSE OF REVIEW: To highlight recently published data about the vitamin D status of athletes, and effect of vitamin D supplementation on muscle strength and performance in the athletic population.The vitamin D receptor exists in skeletal muscle, and muscle weakness has been reported in individuals who are severely deficient [25(OH)D <25 nmol/l]. Vitamin D 110-119 vitamin D receptor Homo sapiens 202-220 24668555-4 2014 Vitamin D inhibits IFN-gamma and IL-17 production while inducing regulatory T cells. Vitamin D 0-9 interleukin 17A Homo sapiens 33-38 25059118-2 2014 Vitamin D exerts its biological effects through its interaction with the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 73-91 25059118-2 2014 Vitamin D exerts its biological effects through its interaction with the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 93-96 25771722-1 2014 The VDR gene is an important regulator of the vitamin D pathway, and the role of some of its polymorphisms on cancer risk was previously investigated. Vitamin D 46-55 vitamin D receptor Homo sapiens 4-7 25353337-10 2014 VDR ApaI aa genotype was positively associated with well-controlled asthma according to GINA and C-ACT questionnaire and negatively associated with decreased limitation in daily activities in asthmatic children, further supporting the importance of Vitamin D pathway in asthma. Vitamin D 249-258 vitamin D receptor Homo sapiens 0-3 25090635-9 2014 Our data suggest that during ductal adenocarcinoma development the vitamin D system in the pancreas becomes deregulated on two levels: in the islets CYP24A1 expression decreases weakening the negative feedback regulation of the vitamin D-dependent insulin synthesis/secretion. Vitamin D 67-76 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 149-156 25090635-10 2014 In the transformed ducts CYP24A1 expression increases, impairing the antiproliferative effect of vitamin D in these cells. Vitamin D 97-106 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 25-32 24975273-6 2014 CONCLUSION: We present a new approach to predict vitamin D target genes based on conserved genomic VDR-binding sites. Vitamin D 49-58 vitamin D receptor Homo sapiens 99-102 25148392-4 2014 Docking experiments on the inhibitors in the CYP24A1 enzyme active site suggest the compounds reach the active site through the vitamin D access tunnel and are exposed to multiple hydrophobic residues. Vitamin D 128-137 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 45-52 25356106-0 2014 High GPX1 expression promotes esophageal squamous cell carcinoma invasion, migration, proliferation and cisplatin-resistance but can be reduced by vitamin D. Vitamin D 147-156 glutathione peroxidase 1 Homo sapiens 5-9 24973411-2 2014 The discovery of fibroblast growth factor 23 (FGF23) as a key regulator of renal phosphate handling and activation of vitamin D has revolutionized our comprehension of phosphate homeostasis. Vitamin D 118-127 fibroblast growth factor 23 Homo sapiens 17-44 24973411-2 2014 The discovery of fibroblast growth factor 23 (FGF23) as a key regulator of renal phosphate handling and activation of vitamin D has revolutionized our comprehension of phosphate homeostasis. Vitamin D 118-127 fibroblast growth factor 23 Homo sapiens 46-51 24973411-3 2014 Through as yet undetermined mechanisms, circulating and dietary phosphate appear to have a direct effect on FGF23 release by bone cells that, in turn, causes renal phosphate excretion and decreases intestinal phosphate absorption through a decrease in vitamin D production. Vitamin D 252-261 fibroblast growth factor 23 Homo sapiens 108-113 24973411-4 2014 Thus, the two major phosphaturic hormones, PTH and FGF23, have opposing effects on vitamin D production, placing vitamin D at the nexus of phosphate homeostasis. Vitamin D 83-92 fibroblast growth factor 23 Homo sapiens 51-56 24973411-4 2014 Thus, the two major phosphaturic hormones, PTH and FGF23, have opposing effects on vitamin D production, placing vitamin D at the nexus of phosphate homeostasis. Vitamin D 113-122 fibroblast growth factor 23 Homo sapiens 51-56 25228524-3 2014 It is claimed that vitamin D inhibits immunological reactions with Th1 and Th17 lymphocytes. Vitamin D 19-28 negative elongation factor complex member C/D Homo sapiens 67-70 25228524-6 2014 It was observed that vitamin D had a beneficial influence on diseases connected with excessive activation of Th1 lymphocytes, such as multiple sclerosis, rheumatoid arthritis, non-specific enteritis, diabetes type 1 or psoriasis. Vitamin D 21-30 negative elongation factor complex member C/D Homo sapiens 109-112 25053401-1 2014 Fibroblast growth factor 23 (FGF23) is secreted primarily by osteocytes and regulates phosphate and vitamin D metabolism. Vitamin D 100-109 fibroblast growth factor 23 Mus musculus 0-27 25053401-1 2014 Fibroblast growth factor 23 (FGF23) is secreted primarily by osteocytes and regulates phosphate and vitamin D metabolism. Vitamin D 100-109 fibroblast growth factor 23 Mus musculus 29-34 24464689-8 2014 The prevalence of vitamin D deficiency was significantly higher in individuals with high anti-TPO than those in lower levels (87.5 vs. 59.5 %, p = 0.001). Vitamin D 18-27 thyroid peroxidase Homo sapiens 94-97 24926821-3 2014 The level of the active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25D), is controlled in part by VDR-dependent induction of cytochrome P450, family 24, subfamily 1, polypeptide1 (CYP24A1), which metabolizes 1,25D to an inactive form. Vitamin D 38-47 vitamin D receptor Homo sapiens 113-116 24926821-3 2014 The level of the active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25D), is controlled in part by VDR-dependent induction of cytochrome P450, family 24, subfamily 1, polypeptide1 (CYP24A1), which metabolizes 1,25D to an inactive form. Vitamin D 38-47 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 195-202 25194407-2 2014 The aim of present study was to evaluate the relationship between vitamin D receptor (VDR) gene FokI and ApaI polymorphisms with serum levels of fetuin-A, vitamin D, and intact PTH in hemodialysis patients. Vitamin D 66-75 vitamin D receptor Homo sapiens 86-89 25194407-10 2014 CONCLUSIONS: Our study shows that increased serum level of PTH and decreased fetuin-A and vitamin D levels may increase susceptibility of atherosclerosis in patients with hemodialysis through VDR gene FokI and ApaI polymorphisms. Vitamin D 90-99 vitamin D receptor Homo sapiens 192-195 24630484-7 2014 The expression of MMP-9, MMP-2, and MMP-3 decreases in the presence of vitamin D derivatives in UC and CD with the exception of 1,25(OH)2D3 that does not affect the levels of MMP-9 and MMP-2 in CD. Vitamin D 71-80 matrix metallopeptidase 9 Homo sapiens 18-23 24630484-8 2014 Vitamin D derivatives always affect MMP-9, MMP-2 and ICAM-1 in PBMC of UC and CD patients. Vitamin D 0-9 matrix metallopeptidase 9 Homo sapiens 36-41 24630484-8 2014 Vitamin D derivatives always affect MMP-9, MMP-2 and ICAM-1 in PBMC of UC and CD patients. Vitamin D 0-9 intercellular adhesion molecule 1 Homo sapiens 53-59 24630484-9 2014 CONCLUSIONS: Based on the increased expression of ICAM-1, MAdCAM-1 and MMP-2,-9,-3 in IBD, our study suggests that vitamin D derivatives may be effective in the management of these diseases. Vitamin D 115-124 intercellular adhesion molecule 1 Homo sapiens 50-56 24926881-11 2014 Up-regulation of TLR2, TLR4 and dectin-1was observed in the lungs and AMs from vitamin D deficient mice both at baseline and after A. fumigatus exposure. Vitamin D 79-88 C-type lectin domain family 7, member a Mus musculus 32-40 24922628-1 2014 BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a hormone involved in phosphorous regulation and vitamin D metabolism that may be associated with cardiovascular risk, and it is a potential target for intervention. Vitamin D 101-110 fibroblast growth factor 23 Homo sapiens 12-39 24922628-1 2014 BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a hormone involved in phosphorous regulation and vitamin D metabolism that may be associated with cardiovascular risk, and it is a potential target for intervention. Vitamin D 101-110 fibroblast growth factor 23 Homo sapiens 41-47 24887145-10 2014 Effects of VDR or VEGF blockade were partially prevented by vitamin D. Vitamin D 60-69 vitamin D receptor Homo sapiens 11-14 24740207-2 2014 Vitamin D-binding protein (DBP) is the primary carrier of vitamin D in the circulation and regulates the bioavailability of 25-hydroxyvitamin D. Vitamin D 58-67 GC vitamin D binding protein Homo sapiens 0-25 24797667-1 2014 Fibroblast growth factor-23 (FGF23) is a bone-derived hormone regulating renal phosphate reabsorption and vitamin D synthesis in renal proximal tubules. Vitamin D 106-115 fibroblast growth factor 23 Mus musculus 0-27 24797667-1 2014 Fibroblast growth factor-23 (FGF23) is a bone-derived hormone regulating renal phosphate reabsorption and vitamin D synthesis in renal proximal tubules. Vitamin D 106-115 fibroblast growth factor 23 Mus musculus 29-34 25031885-1 2014 Fibroblast growth factor 23 (FGF23) is a hormone that is produced by osteocytes and regulates phosphate and vitamin D metabolism through binding to the Klotho-FGF receptor complex. Vitamin D 108-117 fibroblast growth factor 23 Homo sapiens 0-27 25031885-1 2014 Fibroblast growth factor 23 (FGF23) is a hormone that is produced by osteocytes and regulates phosphate and vitamin D metabolism through binding to the Klotho-FGF receptor complex. Vitamin D 108-117 fibroblast growth factor 23 Homo sapiens 29-34 24643654-0 2014 Regulation of CYP27B1 and CYP24A1 hydroxylases limits cell-autonomous activation of vitamin D in dendritic cells. Vitamin D 84-93 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 26-33 24643654-3 2014 Cell-autonomous control of vitamin D activity can be modulated by the action of the vitamin D-activating and -inactivating hydroxylases, CYP27B1, and CYP24A1, respectively. Vitamin D 27-36 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 150-157 24643654-3 2014 Cell-autonomous control of vitamin D activity can be modulated by the action of the vitamin D-activating and -inactivating hydroxylases, CYP27B1, and CYP24A1, respectively. Vitamin D 84-93 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 150-157 24643654-5 2014 Furthermore, in response to stimulation with 1,25[OH]2 D, upregulation of the inactivating enzyme CYP24A1 curtailed the functional effects of vitamin D in DCs, but not macrophages. Vitamin D 142-151 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 98-105 24680778-0 2014 Association of VDR-gene variants with factors related to the metabolic syndrome, type 2 diabetes and vitamin D deficiency. Vitamin D 101-110 vitamin D receptor Homo sapiens 15-18 24680778-2 2014 This study was conducted to assess the association between vitamin D receptor (VDR) polymorphisms and genetic susceptibility to components of the metabolic syndrome, type 2 diabetes mellitus (T2DM), and vitamin D deficiency in the Saudi Arabian population. Vitamin D 59-68 vitamin D receptor Homo sapiens 79-82 24686054-3 2014 The purpose of the present study was to determine the effects of vitamin D deficiency on the phagocytosis rate, intracellular killing, and immune response of murine microglial cultures after stimulation with the Toll-like receptor (TLR) agonists tripalmitoyl-S-glyceryl-cysteine (TLR1/2), poly(I C) (TLR3), lipopolysaccharide (TLR4), and CpG oligodeoxynucleotide (TLR9). Vitamin D 65-74 toll-like receptor 9 Mus musculus 364-368 24638155-2 2014 The aim of the current study was to investigate the association of VDR gene polymorphisms with melanoma risk, clinicopathological characteristics, and vitamin D levels. Vitamin D 151-160 vitamin D receptor Homo sapiens 67-70 24492489-1 2014 BACKGROUND: Vitamin D-deactivating enzyme CYP24A1 had controversial effects on prostate cancer risk; the genetic study also showed the controversial results. Vitamin D 12-21 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 42-49 24347461-8 2014 The inclusion of the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3, in culture enhanced dexamethasone-induced IL-10 (p<0.05) without marked effects on IL-13 or IL-17A production. Vitamin D 36-45 interleukin 10 Homo sapiens 120-125 24347461-8 2014 The inclusion of the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3, in culture enhanced dexamethasone-induced IL-10 (p<0.05) without marked effects on IL-13 or IL-17A production. Vitamin D 36-45 interleukin 17A Homo sapiens 173-179 24347461-9 2014 Furthermore, systemic vitamin D status directly correlated with airway IL-10 (r=0.6, p<0.01). Vitamin D 22-31 interleukin 10 Homo sapiens 71-76 24860512-4 2014 Recent molecular studies have identified an extensive synergistic crosstalk between the vitamin D- and androgen-mediated mRNA and miRNA expression, adding an additional layer of post-transcriptional regulation to the known VDR- and AR-regulated gene activation. Vitamin D 88-97 vitamin D receptor Homo sapiens 223-226 24792400-0 2014 Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells. Vitamin D 0-9 vitamin D receptor Homo sapiens 27-45 24761763-5 2014 Furthermore, due to regulated expression of the metabolizing enzymes CYP27B1 and CYP24A1, B cells have the potential to control the local availability of active vitamin D. Vitamin D 161-170 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 81-88 24790904-2 2014 Recent research on the various molecular activities of the vitamin D system, including the nuclear vitamin D receptor and other receptors for 1,25-dihydroxyvitamin D and vitamin D metabolism, provides evidence that the vitamin D system carries out biological activities across a wide range of tissues similar to other nuclear receptor hormones. Vitamin D 59-68 vitamin D receptor Homo sapiens 99-117 24790904-7 2014 The three major bone cell types, which are osteoblasts, osteocytes and osteoclasts, can all respond to vitamin D via the classical nuclear vitamin D receptor and metabolize 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D to activate the vitamin D receptor and modulate gene expression. Vitamin D 103-112 vitamin D receptor Homo sapiens 139-157 24790904-7 2014 The three major bone cell types, which are osteoblasts, osteocytes and osteoclasts, can all respond to vitamin D via the classical nuclear vitamin D receptor and metabolize 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D to activate the vitamin D receptor and modulate gene expression. Vitamin D 103-112 vitamin D receptor Homo sapiens 236-254 24510435-1 2014 BACKGROUND: Vitamin D plays a role in cancer tumorogenesis and acts through the vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 80-98 24510435-1 2014 BACKGROUND: Vitamin D plays a role in cancer tumorogenesis and acts through the vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 100-103 23995104-1 2014 Vitamin D deficiency is associated with higher cardiovascular risk and metabolic syndrome (MeS) criteria. Vitamin D 0-9 MKS transition zone complex subunit 1 Homo sapiens 91-94 24038189-1 2014 Bone is clearly a target of vitamin D and as expected, the vitamin D receptor (VDR) is expressed in osteoblasts. Vitamin D 28-37 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 59-77 24038189-1 2014 Bone is clearly a target of vitamin D and as expected, the vitamin D receptor (VDR) is expressed in osteoblasts. Vitamin D 28-37 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 79-82 24122604-1 2014 Since the discovery that the enzyme catalyzing the synthesis of the most active natural vitamin D metabolite(calcitriol) and the vitamin D-specific receptor (VDR)were expressed in a wide range of tissues and organs, not only involved in the mineral metabolism (MM), there has been increasing interest on the putative "non classical" roles of vitamin D metabolites, particularly on their possible effects on the cardiovascular (CV) system. Vitamin D 88-97 vitamin D receptor Homo sapiens 158-161 24122604-1 2014 Since the discovery that the enzyme catalyzing the synthesis of the most active natural vitamin D metabolite(calcitriol) and the vitamin D-specific receptor (VDR)were expressed in a wide range of tissues and organs, not only involved in the mineral metabolism (MM), there has been increasing interest on the putative "non classical" roles of vitamin D metabolites, particularly on their possible effects on the cardiovascular (CV) system. Vitamin D 129-138 vitamin D receptor Homo sapiens 158-161 24184224-1 2014 PURPOSE: To test whether single nucleotide polymorphisms (SNPs) of the 4 vitamin D family genes (DHCR7, CYP2R1, CYP27B1, and CYP24A1) previously associated with several autoimmune diseases are associated with ocular Behcet disease, Vogt-Koyanagi-Harada (VKH) syndrome, acute anterior uveitis (AAU) with ankylosing spondylitis, or pediatric uveitis in the Chinese Han population. Vitamin D 73-82 7-dehydrocholesterol reductase Homo sapiens 97-102 24184224-1 2014 PURPOSE: To test whether single nucleotide polymorphisms (SNPs) of the 4 vitamin D family genes (DHCR7, CYP2R1, CYP27B1, and CYP24A1) previously associated with several autoimmune diseases are associated with ocular Behcet disease, Vogt-Koyanagi-Harada (VKH) syndrome, acute anterior uveitis (AAU) with ankylosing spondylitis, or pediatric uveitis in the Chinese Han population. Vitamin D 73-82 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 125-132 24447085-4 2014 Measured vitamin D is largely bound to vitamin D-binding protein (VDBP); VDBP levels are influenced by its gene (GC) haplotype. Vitamin D 9-18 GC vitamin D binding protein Homo sapiens 39-64 24447085-4 2014 Measured vitamin D is largely bound to vitamin D-binding protein (VDBP); VDBP levels are influenced by its gene (GC) haplotype. Vitamin D 9-18 GC vitamin D binding protein Homo sapiens 66-70 24447085-13 2014 The GC1s haplotype is associated with higher VDBP levels, resulting in less freely available vitamin D. Vitamin D 93-102 GC vitamin D binding protein Homo sapiens 45-49 24447085-14 2014 KEY MESSAGES: Vitamin D-binding protein (VDBP) haplotypes influence free vitamin D levels. Vitamin D 73-82 GC vitamin D binding protein Homo sapiens 14-39 24447085-14 2014 KEY MESSAGES: Vitamin D-binding protein (VDBP) haplotypes influence free vitamin D levels. Vitamin D 73-82 GC vitamin D binding protein Homo sapiens 41-45 24428861-3 2014 Clinical research suggests that vitamin D treatment can improve compromised human muscular ability and increase muscle size, supported by loss of motor function and muscle mass in animals following VDR knockout, as well as increased muscle protein synthesis and ATP production following vitamin D supplementation. Vitamin D 32-41 vitamin D receptor Homo sapiens 198-201 24388225-6 2014 The serum IL-10 and IL-13 responses to muscular injury were significantly (both p<0.05) increased in the vitamin D sufficient group. Vitamin D 108-117 interleukin 10 Homo sapiens 10-15 24020384-9 2014 In particular, we highlight the emerging roles of aryl hydrocarbon (AHR), vitamin D (VDR), glucocorticoid (GR) and pregnane X (PXR) receptors in that regulation. Vitamin D 74-83 vitamin D receptor Homo sapiens 85-88 24280059-6 2014 As well as stimulating VDR expression, 25(OH)D and 1,25(OH)(2)D dose-dependently increased expression of the classic vitamin D target cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1), demonstrating the presence of an autoregulatory vitamin D-endocrine system in these cells. Vitamin D 117-126 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 23-26 24280059-6 2014 As well as stimulating VDR expression, 25(OH)D and 1,25(OH)(2)D dose-dependently increased expression of the classic vitamin D target cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1), demonstrating the presence of an autoregulatory vitamin D-endocrine system in these cells. Vitamin D 117-126 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 134-188 24280059-6 2014 As well as stimulating VDR expression, 25(OH)D and 1,25(OH)(2)D dose-dependently increased expression of the classic vitamin D target cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1), demonstrating the presence of an autoregulatory vitamin D-endocrine system in these cells. Vitamin D 117-126 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 190-197 24280059-6 2014 As well as stimulating VDR expression, 25(OH)D and 1,25(OH)(2)D dose-dependently increased expression of the classic vitamin D target cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1), demonstrating the presence of an autoregulatory vitamin D-endocrine system in these cells. Vitamin D 248-257 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 134-188 24280059-6 2014 As well as stimulating VDR expression, 25(OH)D and 1,25(OH)(2)D dose-dependently increased expression of the classic vitamin D target cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1), demonstrating the presence of an autoregulatory vitamin D-endocrine system in these cells. Vitamin D 248-257 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 190-197 24313624-0 2014 Oral vitamin D increases the frequencies of CD38+ human B cells and ameliorates IL-17-producing T cells. Vitamin D 5-14 interleukin 17A Homo sapiens 80-85 23857798-2 2014 The majority of vitamin D in circulation is bound to vitamin D-binding protein (DBP) and albumin, and recent genetic studies have demonstrated that serum DBP is a major determinant of 25(OH)D concentrations in adults. Vitamin D 16-25 GC vitamin D binding protein Homo sapiens 53-78 24053724-2 2014 The goal of this study was evaluate bone metabolism alterations after gastroplasty through the concentrations of carboxy-terminal cross-linking telopeptides of type-I collagen (CTX) and bone-specific alkaline phosphatase (BSAP) and vitamin D status. Vitamin D 232-241 paired box 5 Homo sapiens 222-226 24219580-9 2014 Vitamin D deficiency and its association with VDR gene polymorphisms may be useful to identify the high-risk group individuals. Vitamin D 0-9 vitamin D receptor Homo sapiens 46-49 24436433-3 2014 The active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D, binds to the vitamin D receptor that regulates numerous genes involved in fundamental processes of potential relevance to cardiovascular disease, including cell proliferation and differentiation, apoptosis, oxidative stress, membrane transport, matrix homeostasis, and cell adhesion. Vitamin D 25-34 vitamin D receptor Homo sapiens 79-97 24190897-3 2014 DKKL1 mRNA was repressed 49-72% by 1,25D in primary human and CCD-1106 KERTr keratinocytes; a functional vitamin D responsive element (VDRE) was identified at -9590 bp in murine Soggy. Vitamin D 105-114 dickkopf like acrosomal protein 1 Homo sapiens 0-5 25566549-6 2014 Secondly, detail description of photoproduction of vitamin D, its subsequent metabolism and interaction with vitamin D receptor VDR, provided mechanistic background for future discoveries. Vitamin D 51-60 vitamin D receptor Homo sapiens 109-127 25566549-6 2014 Secondly, detail description of photoproduction of vitamin D, its subsequent metabolism and interaction with vitamin D receptor VDR, provided mechanistic background for future discoveries. Vitamin D 51-60 vitamin D receptor Homo sapiens 128-131 25207361-2 2014 The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 25207368-17 2014 Interestingly, increasing evidence now demonstrates an important function of the vitamin D endocrine system (VDES) for prevention of BCC, SCC and melanoma, identifying the vitamin D receptor as a tumor suppressor in the skin. Vitamin D 81-90 vitamin D receptor Homo sapiens 172-190 25207372-2 2014 The major cell in the epidermis, the keratinocyte, not only produces vitamin D but contains the enzymatic machinery to metabolize vitamin D to its active metabolite, 1,25(OH)2D, and expresses the receptor for this metabolite, the vitamin D receptor (VDR), allowing the cell to respond to the 1,25(OH)2D that it produces. Vitamin D 130-139 vitamin D receptor Homo sapiens 230-248 25207372-2 2014 The major cell in the epidermis, the keratinocyte, not only produces vitamin D but contains the enzymatic machinery to metabolize vitamin D to its active metabolite, 1,25(OH)2D, and expresses the receptor for this metabolite, the vitamin D receptor (VDR), allowing the cell to respond to the 1,25(OH)2D that it produces. Vitamin D 130-139 vitamin D receptor Homo sapiens 250-253 25207372-8 2014 In this chapter we will first discuss recent data regarding potential mechanisms by which vitamin D signaling suppresses tumor formation, then focus on three general mechanisms that mediate tumor suppression by VDR in the skin: inhibition of proliferation and stimulation of differentiation, immune regulation, and stimulation of DNA damage repair (DDR). Vitamin D 90-99 vitamin D receptor Homo sapiens 211-214 25207373-4 2014 In addition to these known responses, there is now sufficient evidence to suggest that the local vitamin D system in skin, which includes local production of the active hormone, 1,25 dihydroxyvitamin D, together with metabolites of over-irradiation products, and vitamin D receptor(s), also provide an adaptive response to UV. Vitamin D 97-106 vitamin D receptor Homo sapiens 263-281 23941558-5 2014 First, we demonstrated that human fetal lung (HFL)-1 cells express the vitamin D receptor (VDR) and that vitamin D, 25-hydroxyvitamin D [25(OH)D], or 1,25-dihydroxyvitamin D [1,25(OH)2D] induce VDR nuclear translocation and increase VDR-DNA binding activity. Vitamin D 71-80 vitamin D receptor Homo sapiens 91-94 23941558-7 2014 Vitamin D, 25(OH)D, and 1,25(OH)2D significantly inhibited IL-1beta-induced microsomal PGE synthase (mPGES)-1 expression; in contrast, all three forms of vitamin D stimulated 15-hydroxy PG dehydrogenase, an enzyme that degrades PGE2. Vitamin D 0-9 prostaglandin E synthase Homo sapiens 87-109 24577200-0 2014 Serum fibroblast growth factor 23 is a useful marker to distinguish vitamin D-deficient rickets from hypophosphatemic rickets. Vitamin D 68-77 fibroblast growth factor 23 Homo sapiens 6-33 24577200-2 2014 Vitamin D deficiency can influence biochemical results of patients with fibroblast growth factor 23 (FGF23)-related hereditary hypophosphatemic rickets (HR), making differential diagnosis difficult. Vitamin D 0-9 fibroblast growth factor 23 Homo sapiens 72-99 24577200-2 2014 Vitamin D deficiency can influence biochemical results of patients with fibroblast growth factor 23 (FGF23)-related hereditary hypophosphatemic rickets (HR), making differential diagnosis difficult. Vitamin D 0-9 fibroblast growth factor 23 Homo sapiens 101-106 25060608-1 2014 BACKGROUND/AIMS: We analyzed the vitamin D receptor (VDR) gene in 2 Greek patients who exhibited the classical features of hereditary vitamin D-resistant rickets (HVDRR) type II, including severe bone deformities and alopecia. Vitamin D 33-42 vitamin D receptor Homo sapiens 53-56 24899892-1 2014 Vitamin D-binding protein (DBP) is the main transport protein of vitamin D and plays an important role in the immune system and host defenses. Vitamin D 65-74 GC vitamin D binding protein Homo sapiens 0-25 23296792-1 2014 Fibroblast growth factor-23 (FGF-23) has emerged as an important hormone involved in phosphorus and vitamin D homeostasis. Vitamin D 100-109 fibroblast growth factor 23 Homo sapiens 0-27 23296792-1 2014 Fibroblast growth factor-23 (FGF-23) has emerged as an important hormone involved in phosphorus and vitamin D homeostasis. Vitamin D 100-109 fibroblast growth factor 23 Homo sapiens 29-35 24967273-8 2014 The circulating interleukin-(IL-)10 and interferon-(IFN-) gamma concentrations were significantly higher in the vitamin D sufficient athletes. Vitamin D 112-121 interleukin 10 Homo sapiens 16-63 23623649-1 2014 Fibroblast growth factor 23 (FGF-23) is a bone-derived circulating phosphaturic factor that decreases serum concentration of phosphate and vitamin D, suggested to actively participate in a complex renal-gastrointestinal-skeletal axis. Vitamin D 139-148 fibroblast growth factor 23 Homo sapiens 0-27 23623649-1 2014 Fibroblast growth factor 23 (FGF-23) is a bone-derived circulating phosphaturic factor that decreases serum concentration of phosphate and vitamin D, suggested to actively participate in a complex renal-gastrointestinal-skeletal axis. Vitamin D 139-148 fibroblast growth factor 23 Homo sapiens 29-35 24284821-8 2014 Our data demonstrate the importance of intact VDR signaling in the preservation of vascular function and may provide a mechanistic explanation for epidemiological data in humans showing that vitamin D insufficiency is associated with hypertension and endothelial dysfunction. Vitamin D 191-200 vitamin D receptor Homo sapiens 46-49 24048755-1 2014 Vitamin D receptor (VDR) principally mediates the anticancer activities of vitamin D. Vitamin D 75-84 vitamin D receptor Homo sapiens 0-18 24048755-1 2014 Vitamin D receptor (VDR) principally mediates the anticancer activities of vitamin D. Vitamin D 75-84 vitamin D receptor Homo sapiens 20-23 24140714-1 2013 Calcium has recently been shown to regulate fibroblast growth factor 23 (FGF-23), a bone-derived phosphate and vitamin D-regulating hormone. Vitamin D 111-120 fibroblast growth factor 23 Mus musculus 44-71 24140714-1 2013 Calcium has recently been shown to regulate fibroblast growth factor 23 (FGF-23), a bone-derived phosphate and vitamin D-regulating hormone. Vitamin D 111-120 fibroblast growth factor 23 Mus musculus 73-79 24102630-1 2013 Vitamin D acts through binding with vitamin D receptor (VDR) and is responsible for regulating bone metabolism and mineralization; it also suppresses the immune system. Vitamin D 0-9 vitamin D receptor Homo sapiens 36-54 24102630-1 2013 Vitamin D acts through binding with vitamin D receptor (VDR) and is responsible for regulating bone metabolism and mineralization; it also suppresses the immune system. Vitamin D 0-9 vitamin D receptor Homo sapiens 56-59 24245571-3 2013 Concerning the synthesis of vitamin D, the hydroxylases CYP2R1, CYP27B1 and CYP24A1 play a critical role, and the latter molecule determines the biological half-life of 1,25(OH)2 D3 , which is synthesized in the proximal renal tubules. Vitamin D 28-37 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 76-83 24245571-9 2013 CONCLUSION: We thus conclude that upregulated gene expression of the catabolizing CYP24A1 as well as the synthesizing CYP2R1 and CYP27B1 may lead to a misbalance of vitamin D metabolites in ccRCC and thus contributing to its pathogenesis. Vitamin D 165-174 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 82-89 24007655-3 2013 The study aimed to test whether vitamin D binding protein (VDBP or GC-group component) and vitamin D receptor (VDR) gene polymorphisms were associated with asthma characteristics as well as vitamin D level in Egyptian children. Vitamin D 32-41 GC vitamin D binding protein Homo sapiens 59-63 23744843-0 2013 Analyses of RANK and RANKL in the post-GWAS context: functional evidence of vitamin D stimulation through a RANKL distal region. Vitamin D 76-85 TNF superfamily member 11 Homo sapiens 108-113 23744843-9 2013 In conclusion, the GWA-associated SNP rs9594738 lies in a region involved in transcription regulation through which vitamin D could be regulating RANKL expression and bone mineral density. Vitamin D 116-125 TNF superfamily member 11 Homo sapiens 146-151 24108316-11 2013 Further work is needed to determine whether the observed effect of vitamin D on fiber size is mediated by the VDR and to identify which signaling pathways are involved. Vitamin D 67-76 vitamin D receptor Homo sapiens 110-113 24011919-0 2013 Involvement of peroxisome proliferator-activated receptor gamma in vitamin D-mediated protection against acute kidney injury in rats. Vitamin D 67-76 peroxisome proliferator-activated receptor gamma Rattus norvegicus 15-63 24011919-3 2013 The present study investigated the activation of PPAR-gamma as novel mechanism in vitamin D-mediated protection against ischemia reperfusion-induced acute kidney injury (AKI) in rats. Vitamin D 82-91 peroxisome proliferator-activated receptor gamma Rattus norvegicus 49-59 24078452-1 2013 The polymorphism of vitamin D receptor (VDR) gene is demonstrated to affect the activity of its encoding protein and the subsequent downstream effects mediated by vitamin D. Vitamin D 20-29 vitamin D receptor Homo sapiens 40-43 24202452-5 2013 We will examine two pathways, beta-catenin (CTNNB) and hedgehog (HH), that are regulated by vitamin D signaling and may contribute to the dysregulated proliferation and differentiation in the absence of VDR. Vitamin D 92-101 catenin (cadherin associated protein), beta 1 Mus musculus 30-42 24202452-7 2013 Finally we will examine the change in long non-coding RNA (LncRNA) expression in VDR null keratinocytes that in other cells is associated with malignant transformation, a potential newly appreciated mechanism by which vitamin D signaling is protective against NMSC. Vitamin D 218-227 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 81-84 23664548-3 2013 In particular, there is accumulating evidence indicating a key role for the complex and yet incompletely understood system of divalent cation regulation, which includes phosphate metabolism and the recently discovered fibroblast growth factor 23 (FGF-23)/klotho system, which seems inextricably associated with vitamin D deficiency. Vitamin D 311-320 fibroblast growth factor 23 Homo sapiens 218-245 23664548-3 2013 In particular, there is accumulating evidence indicating a key role for the complex and yet incompletely understood system of divalent cation regulation, which includes phosphate metabolism and the recently discovered fibroblast growth factor 23 (FGF-23)/klotho system, which seems inextricably associated with vitamin D deficiency. Vitamin D 311-320 fibroblast growth factor 23 Homo sapiens 247-253 24051166-5 2013 Many non-classical effects of vitamin D are suggested by the quasi-ubiquitous presence of the vitamin D receptor and by myriads of studies showing an association between vitamin D deficiency/insufficiency and an increased incidence or a poor prognostic of many diseases. Vitamin D 30-39 vitamin D receptor Homo sapiens 94-112 24084050-8 2013 Two variants: rs731236[A] (VDR) and rs732594[A] (SCUBE3) showed a significant association with serum Vit D levels in CD patients. Vitamin D 101-106 vitamin D receptor Homo sapiens 27-30 23735647-1 2013 Previous studies have suggested that vitamin D deficiency might contribute to the pathogenesis of heart failure (HF); however, limited data are available on the association of vitamin D-binding protein (VDBP)--a major transport protein for vitamin D--and the development of HF. Vitamin D 176-185 GC vitamin D binding protein Homo sapiens 203-207 23463632-1 2013 In colorectal cancer (CRC) the vitamin D catabolizing enzyme 1,25-dihydroxyvitamin D 24-hydroxylase (CYP24A1) is overexpressed with a potentially significant, positive impact on the catabolism of 1,25-dihydroxyvitamin D3 (1,25-D3 ). Vitamin D 31-40 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 101-108 23944708-0 2013 Crystal structures of hereditary vitamin D-resistant rickets-associated vitamin D receptor mutants R270L and W282R bound to 1,25-dihydroxyvitamin D3 and synthetic ligands. Vitamin D 33-42 vitamin D receptor Homo sapiens 72-90 23944708-2 2013 Hereditary vitamin D-resistant rickets (HVDRR), an autosomal recessive disease, is caused by mutations in the VDR. Vitamin D 11-20 vitamin D receptor Homo sapiens 41-44 23721405-1 2013 Vitamin D receptor is a mediator of immune responses through the action of vitamin D, which is capable of regulate the insulin secretion by the pancreas. Vitamin D 75-84 vitamin D receptor Homo sapiens 0-18 23721405-2 2013 Since polymorphisms in the vitamin D receptor (VDR) gene might modulate vitamin D function, and thus immunologic response, VDR is possibly able to influence the predisposition to type 1 diabetes mellitus (T1DM). Vitamin D 27-36 vitamin D receptor Homo sapiens 47-50 23721405-2 2013 Since polymorphisms in the vitamin D receptor (VDR) gene might modulate vitamin D function, and thus immunologic response, VDR is possibly able to influence the predisposition to type 1 diabetes mellitus (T1DM). Vitamin D 27-36 vitamin D receptor Homo sapiens 123-126 23625971-4 2013 FGF23 is a hormone produced by osteoblasts/osteocytes in bone that acts on the kidney to regulate phosphate and vitamin D metabolism through activation of FGF receptor/alpha-Klotho co-receptor complexes. Vitamin D 112-121 fibroblast growth factor 23 Homo sapiens 0-5 24119849-3 2013 Mounting evidence from animal and clinical studies has shown beneficial effects of vitamin D therapy on the renal and cardiovascular systems, and the underlying renoprotective and cardioprotective mechanisms of vitamin D receptor (VDR)-mediated signaling are under intense investigation. Vitamin D 83-92 vitamin D receptor Homo sapiens 231-234 24034921-8 2013 1,25-(OH)2D3 inhibits the expression of IL-13 and IL-17, suggesting that vitamin D intake may provide protective effects in the development of atopy-predisposing immune responses in early life. Vitamin D 73-82 interleukin 17A Homo sapiens 50-55 24015259-1 2013 OBJECTIVE: Fibroblast growth factor 23 (FGF23) is a circulating regulator of phosphate and vitamin D metabolism and is associated with coronary artery calcification, and has been implicated in the pathogenesis of cardiovascular disease. Vitamin D 91-100 fibroblast growth factor 23 Homo sapiens 11-38 24015259-1 2013 OBJECTIVE: Fibroblast growth factor 23 (FGF23) is a circulating regulator of phosphate and vitamin D metabolism and is associated with coronary artery calcification, and has been implicated in the pathogenesis of cardiovascular disease. Vitamin D 91-100 fibroblast growth factor 23 Homo sapiens 40-45 23619147-15 2013 Reagents designed to target JMJD1A or its messenger RNA, or increase the function of miR-627, might have the same antitumor activities of vitamin D without the hypercalcemic side effects. Vitamin D 138-147 lysine (K)-specific demethylase 3A Mus musculus 28-34 23683514-2 2013 We previously identified a steroid-enhancing function of vitamin D in patients with SR asthma in restoring the impaired response to steroids for production of the anti-inflammatory cytokine IL-10. Vitamin D 57-66 interleukin 10 Homo sapiens 190-195 23683514-3 2013 OBJECTIVE: We sought to investigate the production of the TH17-associated cytokines IL-17A and IL-22 in culture in patients with moderate-to-severe asthma defined on the basis of their clinical response to steroids and the susceptibility of this response to inhibition by steroids and the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25[OH]2D3). Vitamin D 304-313 interleukin 17A Homo sapiens 84-90 23683514-3 2013 OBJECTIVE: We sought to investigate the production of the TH17-associated cytokines IL-17A and IL-22 in culture in patients with moderate-to-severe asthma defined on the basis of their clinical response to steroids and the susceptibility of this response to inhibition by steroids and the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25[OH]2D3). Vitamin D 304-313 interleukin 22 Homo sapiens 95-100 23505057-1 2013 Fibroblast growth factor 23 (FGF23) is an osteocyte-derived hormone that regulates phosphate and vitamin D homeostasis. Vitamin D 97-106 fibroblast growth factor 23 Homo sapiens 0-27 23505057-1 2013 Fibroblast growth factor 23 (FGF23) is an osteocyte-derived hormone that regulates phosphate and vitamin D homeostasis. Vitamin D 97-106 fibroblast growth factor 23 Homo sapiens 29-34 23030238-10 2013 LPS-induced IL-6 and RANTES expression was decreased, and BLC expression was totally reversed, by vitamin D treatment. Vitamin D 98-107 C-C motif chemokine ligand 5 Homo sapiens 21-27 23030238-10 2013 LPS-induced IL-6 and RANTES expression was decreased, and BLC expression was totally reversed, by vitamin D treatment. Vitamin D 98-107 C-X-C motif chemokine ligand 13 Homo sapiens 58-61 23470222-13 2013 CYP24A1 mutations should be considered in the differential diagnosis of hypercalciuric nephrolithiasis, especially as many adults are now prescribed supplemental oral vitamin D. Vitamin D 167-176 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 0-7 23621113-5 2013 METHODS: The influence of vitamin D treatment on the transcriptional level of insulin receptor (IR), insulin receptor substrate (IRS-1), glucose transporter type 4 (GLUT-4), and vitamin D receptor (VDR) in insulin target tissues of liver, adipose, and muscle of mice fed on a high-fat diet (HFD) or low-fat diet (LFD) was studied by quantitative RT-PCR. Vitamin D 26-35 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 198-201 23621113-7 2013 In HFD mice, vitamin D decreased VDR expression to 0.5-fold in muscle (P=0.002), and increased it to 3.6-fold in the liver (P<0.001); however, VDR transcription was unaltered in adipose tissue. Vitamin D 13-22 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 33-36 23621113-7 2013 In HFD mice, vitamin D decreased VDR expression to 0.5-fold in muscle (P=0.002), and increased it to 3.6-fold in the liver (P<0.001); however, VDR transcription was unaltered in adipose tissue. Vitamin D 13-22 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 146-149 23865526-5 2013 An involvement of MLN could explain the diverse findings in the epidemiology, immunology and pathology of MS, requiring a consideration of a complex infectious background, the human leucocyte antigens, as well as cosmic radiation causing geomagnetic disturbances, vitamin D deficiency, smoking, and lower levels of uric acid. Vitamin D 264-273 motilin Homo sapiens 18-21 23849224-15 2013 Our results also suggest that VDR binding in response to physiological levels of vitamin D occurs predominantly in a VDR motif-independent manner. Vitamin D 81-90 vitamin D receptor Homo sapiens 30-33 23849224-15 2013 Our results also suggest that VDR binding in response to physiological levels of vitamin D occurs predominantly in a VDR motif-independent manner. Vitamin D 81-90 vitamin D receptor Homo sapiens 117-120 23837623-0 2013 DHCR7 mutations linked to higher vitamin D status allowed early human migration to northern latitudes. Vitamin D 33-42 7-dehydrocholesterol reductase Homo sapiens 0-5 23837623-10 2013 CONCLUSIONS: Our results suggest that genetic variation in DHCR7 is the major adaptation affecting vitamin D metabolism in recent evolutionary history which helped early humans to avoid severe vitamin D deficiency and enabled them to inhabit areas further from the equator. Vitamin D 99-108 7-dehydrocholesterol reductase Homo sapiens 59-64 23857228-1 2013 The role of vitamin D in maintaining health appears greater than originally thought, and the concept of the vitamin D axis underlines the complexity of the biological events controlled by biologically active vitamin D (1,25(OH)(2)D3), its two binding proteins that are the vitamin D receptor (VDR) and the vitamin D-binding protein-derived macrophage activating factor (GcMAF). Vitamin D 108-117 vitamin D receptor Homo sapiens 273-291 23857228-1 2013 The role of vitamin D in maintaining health appears greater than originally thought, and the concept of the vitamin D axis underlines the complexity of the biological events controlled by biologically active vitamin D (1,25(OH)(2)D3), its two binding proteins that are the vitamin D receptor (VDR) and the vitamin D-binding protein-derived macrophage activating factor (GcMAF). Vitamin D 108-117 vitamin D receptor Homo sapiens 293-296 23857228-1 2013 The role of vitamin D in maintaining health appears greater than originally thought, and the concept of the vitamin D axis underlines the complexity of the biological events controlled by biologically active vitamin D (1,25(OH)(2)D3), its two binding proteins that are the vitamin D receptor (VDR) and the vitamin D-binding protein-derived macrophage activating factor (GcMAF). Vitamin D 108-117 GC vitamin D binding protein Homo sapiens 306-376 23857228-1 2013 The role of vitamin D in maintaining health appears greater than originally thought, and the concept of the vitamin D axis underlines the complexity of the biological events controlled by biologically active vitamin D (1,25(OH)(2)D3), its two binding proteins that are the vitamin D receptor (VDR) and the vitamin D-binding protein-derived macrophage activating factor (GcMAF). Vitamin D 108-117 vitamin D receptor Homo sapiens 273-291 23857228-1 2013 The role of vitamin D in maintaining health appears greater than originally thought, and the concept of the vitamin D axis underlines the complexity of the biological events controlled by biologically active vitamin D (1,25(OH)(2)D3), its two binding proteins that are the vitamin D receptor (VDR) and the vitamin D-binding protein-derived macrophage activating factor (GcMAF). Vitamin D 108-117 vitamin D receptor Homo sapiens 293-296 23857228-1 2013 The role of vitamin D in maintaining health appears greater than originally thought, and the concept of the vitamin D axis underlines the complexity of the biological events controlled by biologically active vitamin D (1,25(OH)(2)D3), its two binding proteins that are the vitamin D receptor (VDR) and the vitamin D-binding protein-derived macrophage activating factor (GcMAF). Vitamin D 108-117 GC vitamin D binding protein Homo sapiens 306-376 23857228-5 2013 This allows 1,25(OH)(2)D3 and oleic acid to become sandwiched between the two vitamin D-binding proteins, thus postulating a novel molecular mode of interaction between GcMAF and VDR. Vitamin D 78-87 GC vitamin D binding protein Homo sapiens 169-174 23857228-5 2013 This allows 1,25(OH)(2)D3 and oleic acid to become sandwiched between the two vitamin D-binding proteins, thus postulating a novel molecular mode of interaction between GcMAF and VDR. Vitamin D 78-87 vitamin D receptor Homo sapiens 179-182 23362149-1 2013 When bound to the vitamin D receptor (VDR), the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) is a potent regulator of osteoblast transcription. Vitamin D 18-27 vitamin D receptor Homo sapiens 38-41 23426901-0 2013 Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget"s disease. Vitamin D 39-48 TATA-box binding protein associated factor 12 Homo sapiens 13-18 23426901-7 2013 Chromatin immunoprecipitation (ChIP) analysis of OCL precursors using an anti-TAF12 antibody demonstrated that TAF12 binds the 24-hydroxylase (CYP24A1) promoter, which contains two functional vitamin D response elements (VDREs), in the presence of 1,25-(OH)2D3. Vitamin D 192-201 TATA-box binding protein associated factor 12 Homo sapiens 111-116 23426901-7 2013 Chromatin immunoprecipitation (ChIP) analysis of OCL precursors using an anti-TAF12 antibody demonstrated that TAF12 binds the 24-hydroxylase (CYP24A1) promoter, which contains two functional vitamin D response elements (VDREs), in the presence of 1,25-(OH)2D3. Vitamin D 192-201 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 143-150 23858619-0 2013 Vitamin D action: lessons from VDR and Cyp27b1 null mice. Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 31-34 23858619-2 2013 Inactivation of the vitamin D receptor (VDR) or the enzymes metabolizing its ligand (especially Cyp27bl) in mice has clearly demonstrated that the active form of vitamin D [1,25(OH)2D] is essential to stimulate calcium absorption in the gut during normal/low calcium intake, and as a consequence, that 1,25(OH)2D is required to maintain normal serum calcium, bone and growth plate homeostasis. Vitamin D 20-29 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 40-43 23212742-2 2013 Human CYP24A1, CYP3A4, and CYP27B1 catalyze the inactivation and activation of vitamin D and have been implicated in the adverse drug response. Vitamin D 79-88 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 6-13 23569273-6 2013 Concordantly, the mobility of circulating CX3CR1(+) osteoclast precursor monocytes was significantly increased on systemic administration of active vitamin D. Vitamin D 148-157 chemokine (C-X3-C motif) receptor 1 Mus musculus 42-48 23443925-1 2013 Fibroblast growth factor 23 (FGF23) is a hormone released primarily by osteocytes that regulates phosphate and vitamin D metabolism. Vitamin D 111-120 fibroblast growth factor 23 Homo sapiens 0-27 23443925-1 2013 Fibroblast growth factor 23 (FGF23) is a hormone released primarily by osteocytes that regulates phosphate and vitamin D metabolism. Vitamin D 111-120 fibroblast growth factor 23 Homo sapiens 29-34 23423976-0 2013 CYP24A1 and CYP27B1 polymorphisms modulate vitamin D metabolism in colon cancer cells. Vitamin D 43-52 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 0-7 23530237-0 2013 Sclerostin alters serum vitamin D metabolite and fibroblast growth factor 23 concentrations and the urinary excretion of calcium. Vitamin D 24-33 sclerostin Mus musculus 0-10 23585857-6 2013 RESULTS: Almost half (47%) of the S-25-OHD values were consistent with subnormal vitamin D status (S-25-OHD <50 nmol/L) while only 12% were >80 nmol/L. Vitamin D 81-90 ribosomal protein S25 Homo sapiens 34-42 23585857-8 2013 Mean S-25-OHD concentration differed between age groups (Kruskal-Wallis; p<0.001), adolescents being at highest risk for vitamin D insufficiency. Vitamin D 124-133 ribosomal protein S25 Homo sapiens 5-13 23311753-3 2013 We hypothesised that bortezomib could influence osteoblastic differentiation via alteration of vitamin D signalling by blocking the proteasomal degradation of the vitamin D receptor (VDR). Vitamin D 95-104 vitamin D receptor Homo sapiens 163-181 23311753-3 2013 We hypothesised that bortezomib could influence osteoblastic differentiation via alteration of vitamin D signalling by blocking the proteasomal degradation of the vitamin D receptor (VDR). Vitamin D 95-104 vitamin D receptor Homo sapiens 183-186 23703334-2 2013 Regulation of bone and mineral metabolism is a classic vitamin D effect, but the identification of the vitamin D receptor (VDR) in almost all human cells suggests a role for vitamin D also in extra-skeletal diseases. Vitamin D 103-112 vitamin D receptor Homo sapiens 123-126 23247634-6 2013 Characterizing the vitamin D downstream effector, we found that vitamin D up-regulated SirT-1 and reverted the SirT-1 down-regulation induced by H2O2. Vitamin D 19-28 sirtuin 1 Homo sapiens 111-117 23247634-6 2013 Characterizing the vitamin D downstream effector, we found that vitamin D up-regulated SirT-1 and reverted the SirT-1 down-regulation induced by H2O2. Vitamin D 64-73 sirtuin 1 Homo sapiens 87-93 23247634-6 2013 Characterizing the vitamin D downstream effector, we found that vitamin D up-regulated SirT-1 and reverted the SirT-1 down-regulation induced by H2O2. Vitamin D 64-73 sirtuin 1 Homo sapiens 111-117 23247634-7 2013 ERKs activation by vitamin D strictly correlated with SirT-1 protein accumulation since both MEKs/ERKs inhibition and ERK1/2 silencing decreased SIRT-1. Vitamin D 19-28 sirtuin 1 Homo sapiens 54-60 23247634-7 2013 ERKs activation by vitamin D strictly correlated with SirT-1 protein accumulation since both MEKs/ERKs inhibition and ERK1/2 silencing decreased SIRT-1. Vitamin D 19-28 sirtuin 1 Homo sapiens 145-151 23247634-8 2013 SirT-1 inhibition by Sirtinol reverted the vitamin D anti-oxidant effects. Vitamin D 43-52 sirtuin 1 Homo sapiens 0-6 23247634-9 2013 Thus, vitamin D significantly reduced the endothelial malfunction and damage caused by oxidative stress, through the activation of MEKs/ERKs/SirT-1 axis. Vitamin D 6-15 sirtuin 1 Homo sapiens 141-147 23117582-1 2013 Fibroblast growth factor 23 (FGF23) is an "endocrine" FGF acting in the kidney as a phosphaturic hormone and a suppressor of active vitamin D, through an inhibition of the 1alpha hydroxylase and a stimulation of the 24 hydroxylase. Vitamin D 132-141 fibroblast growth factor 23 Homo sapiens 0-27 23117582-1 2013 Fibroblast growth factor 23 (FGF23) is an "endocrine" FGF acting in the kidney as a phosphaturic hormone and a suppressor of active vitamin D, through an inhibition of the 1alpha hydroxylase and a stimulation of the 24 hydroxylase. Vitamin D 132-141 fibroblast growth factor 23 Homo sapiens 29-34 23012315-4 2013 In the presence of LPS, vitamin D caused dose-dependent decreases in the messenger RNA expression of MCP-1, IL-1beta, IL-13, TNF-alpha, TLR-4, and TLR-5, the contractile-associated proteins connexin 43, the oxytocin receptor, and the prostaglandin receptor but caused increases in IL-10 and TLR-10 in UtSM cells. Vitamin D 24-33 interleukin 10 Homo sapiens 281-286 23449998-5 2013 The IFN-gamma-induced macrophage vitamin D-dependent antimicrobial peptide response was inhibited by IFN-beta and by IL-10, suggesting that the differential production of IFNs contributes to protection versus pathogenesis in some human bacterial infections. Vitamin D 33-42 interleukin 10 Homo sapiens 117-122 23322908-4 2013 Vitamin D also exerts its effects on AD by regulating calcium-sensing receptor expression, enhancing amyloid-beta peptides clearance, interleukin 10, downregulating matrix metalloproteinases, upregulating heme oxygenase 1, and suppressing the reduced form of nicotinamide adenine dinucleotide phosphate expression. Vitamin D 0-9 interleukin 10 Homo sapiens 134-148 23370372-6 2013 Vitamin D acts on a number of cells involved in both innate and acquired immunity biasing the adaptive immune system away from Th17 and Th1, towards Th2 and Tregs. Vitamin D 0-9 negative elongation factor complex member C/D Homo sapiens 127-130 23465500-2 2013 FGF23 is important in the regulation of phosphate and vitamin D metabolism, whereas Ocn participates in endocrine networks, coordinating bone and fat mass, energy metabolism, and sex hormone production. Vitamin D 54-63 fibroblast growth factor 23 Homo sapiens 0-5 23465502-2 2013 Renal vitamin D metabolism requires filtration and tubular reabsorption of 25-hydroxyvitamin D and is regulated by parathyroid hormone, fibroblast growth factor-23, and 1,25-dihydroxyvitamin D. Vitamin D 6-15 fibroblast growth factor 23 Homo sapiens 136-163 23465502-4 2013 In addition, pharmacokinetic studies and epidemiologic studies of 24,25-dihydroxyvitamin D, the most abundant product of 25-hydroxyvitamin D catabolism by CYP24A1, suggest that vitamin D catabolism also is reduced. Vitamin D 81-90 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 155-162 23393347-2 2013 The enzyme 25-hydroxyvitamin D 24-hydroxylase (CYP24A1), which degrades the active form of vitamin D, and the vitamin D receptor (VDR) are both found in breast tissue. Vitamin D 21-30 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 47-54 23393347-2 2013 The enzyme 25-hydroxyvitamin D 24-hydroxylase (CYP24A1), which degrades the active form of vitamin D, and the vitamin D receptor (VDR) are both found in breast tissue. Vitamin D 21-30 vitamin D receptor Homo sapiens 110-128 23393347-2 2013 The enzyme 25-hydroxyvitamin D 24-hydroxylase (CYP24A1), which degrades the active form of vitamin D, and the vitamin D receptor (VDR) are both found in breast tissue. Vitamin D 21-30 vitamin D receptor Homo sapiens 130-133 22915280-6 2013 The results showed a statistically significant positive correlation between the levels of ALP with IFN-gamma, PTH with IL-17 and a significant negative correlation between P with IL-10 in vitamin D deficient group. Vitamin D 188-197 interleukin 10 Homo sapiens 179-184 22740316-8 2013 The downregulated 24-hydroxylase (Cyp24a1) gene expression in femoral bone indicated local vitamin D resistance in the mice treated with ZK191784. Vitamin D 91-100 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 34-41 23356636-9 2013 The analysis of CCT data identified vitamin D as a promising caries-preventive agent, leading to a low-certainty conclusion that vitamin D may reduce the incidence of caries. Vitamin D 36-45 CCT Homo sapiens 16-19 23178257-4 2013 Thus, vitamin D signaling primarily implies the molecular actions of the VDR. Vitamin D 6-15 vitamin D receptor Homo sapiens 73-76 23160964-7 2013 These data demonstrate that 1,25-dihydroxyvitamin D stimulates adipose leptin production in a VDR-dependent manner, suggesting that vitamin D may affect energy homeostasis through direct regulation of leptin expression. Vitamin D 42-51 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 94-97 24348674-2 2013 Considering that 1,25(OH)2D3 has been suggested as a potent inducer of RANKL expression, it should clarify whether vitamin D supplement could result in RANKL overexpression and thereby facilitate excessive osteoclastogenesis and bone resorption in RA. Vitamin D 115-124 TNF superfamily member 11 Homo sapiens 71-76 24348674-2 2013 Considering that 1,25(OH)2D3 has been suggested as a potent inducer of RANKL expression, it should clarify whether vitamin D supplement could result in RANKL overexpression and thereby facilitate excessive osteoclastogenesis and bone resorption in RA. Vitamin D 115-124 TNF superfamily member 11 Homo sapiens 152-157 23724632-0 2013 Vitamin D status in female students and its relation to calcium metabolism markers, lifestyles, and polymorphism in vitamin D receptor. Vitamin D 0-9 vitamin D receptor Homo sapiens 116-134 23724632-3 2013 The aim of this study was to evaluate the prevalence of vitamin D deficiency and its relation with vitamin D receptor (VDR) gene polymorphism. Vitamin D 56-65 vitamin D receptor Homo sapiens 99-117 23724632-3 2013 The aim of this study was to evaluate the prevalence of vitamin D deficiency and its relation with vitamin D receptor (VDR) gene polymorphism. Vitamin D 56-65 vitamin D receptor Homo sapiens 119-122 23724632-9 2013 There was a significant relationship between serum levels of vitamin D with ionized Ca, PTH, ALP, type of clothing, and egg consumption, while no significant relationship was found between serum levels of vitamin D with age, residency, menstruation status, skin color, sun light exposure, body mass index, waist to hip ratio, exercise, physical activity, fish consumption, and polymorphisms in exon 9 of VDR gene. Vitamin D 61-70 ATHS Homo sapiens 93-96 23206185-2 2013 Fibroblast growth factor 23 (FGF23) and its obligatory co-receptor Klotho (KL) play a key role in this process by influencing both renal phosphate reabsorption and vitamin D metabolism. Vitamin D 164-173 fibroblast growth factor 23 Homo sapiens 0-27 23879537-5 2013 The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D) functions as a steroid hormone that, when bound to its nuclear vitamin D receptor, is able to regulate target gene expression. Vitamin D 19-28 vitamin D receptor Homo sapiens 130-148 24617042-12 2013 In conclusion, 84.8% of children with type-1 DM have low circulating levels of 25(OH) D. These patients have poor glycemic control (56.06%) than those with sufficient levels of 25(OH) D. Fokl polymorphism of VDR gene is associated with vitamin D deficiency but has no significant role in susceptibility to type-1 diabetes. Vitamin D 236-245 vitamin D receptor Homo sapiens 208-211 23001465-7 2013 The CYP24A1 gene mutation leads to the increased sensitivity of the patients to even prophylactic doses of vitamin D and to the development of severe symptomatic hypercalcemia in patients with IIH. Vitamin D 107-116 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 4-11 22886720-9 2013 Elevated expression of FGF23 may therefore play a crucial role in defining immune responses to vitamin D and this, in turn, may be a key determinant of infection in patients with chronic kidney disease (CKD). Vitamin D 95-104 fibroblast growth factor 23 Homo sapiens 23-28 23085014-9 2013 Serum 25-OHD(3) concentration is only poorly responsive to increases in vitamin D intake, and the prolonged routine consumption of thousands of international units of vitamin D may interfere with the regulation of phosphate homeostasis by fibroblast growth factor-23 (FGF23) and the Klotho gene product, with consequences that are detrimental to human health. Vitamin D 167-176 fibroblast growth factor 23 Homo sapiens 239-266 23085014-9 2013 Serum 25-OHD(3) concentration is only poorly responsive to increases in vitamin D intake, and the prolonged routine consumption of thousands of international units of vitamin D may interfere with the regulation of phosphate homeostasis by fibroblast growth factor-23 (FGF23) and the Klotho gene product, with consequences that are detrimental to human health. Vitamin D 167-176 fibroblast growth factor 23 Homo sapiens 268-273 23085014-9 2013 Serum 25-OHD(3) concentration is only poorly responsive to increases in vitamin D intake, and the prolonged routine consumption of thousands of international units of vitamin D may interfere with the regulation of phosphate homeostasis by fibroblast growth factor-23 (FGF23) and the Klotho gene product, with consequences that are detrimental to human health. Vitamin D 167-176 klotho Homo sapiens 283-289 23527013-9 2013 Seventeen vitamin D-regulated genes with new candidate vitamin D response elements including TRIM27, CD83, COPB2, YRNA and CETN3 which have been shown to be important for transcriptional regulation, immune function, response to stress and DNA repair were identified. Vitamin D 10-19 tripartite motif containing 27 Homo sapiens 93-99 23527013-9 2013 Seventeen vitamin D-regulated genes with new candidate vitamin D response elements including TRIM27, CD83, COPB2, YRNA and CETN3 which have been shown to be important for transcriptional regulation, immune function, response to stress and DNA repair were identified. Vitamin D 10-19 centrin 3 Homo sapiens 123-128 23527013-9 2013 Seventeen vitamin D-regulated genes with new candidate vitamin D response elements including TRIM27, CD83, COPB2, YRNA and CETN3 which have been shown to be important for transcriptional regulation, immune function, response to stress and DNA repair were identified. Vitamin D 55-64 tripartite motif containing 27 Homo sapiens 93-99 23527013-9 2013 Seventeen vitamin D-regulated genes with new candidate vitamin D response elements including TRIM27, CD83, COPB2, YRNA and CETN3 which have been shown to be important for transcriptional regulation, immune function, response to stress and DNA repair were identified. Vitamin D 55-64 centrin 3 Homo sapiens 123-128 23326564-0 2013 Targeting CD44-STAT3 signaling by Gemini vitamin D analog leads to inhibition of invasion in basal-like breast cancer. Vitamin D 41-50 CD44 molecule (Indian blood group) Homo sapiens 10-14 23326564-2 2013 We have previously demonstrated that the novel Gemini vitamin D analog BXL0124 [1alpha,25-dihydroxy-20R-21(3-hydroxy-3-deuteromethyl-4,4,4-trideuterobutyl)-23-yne-26,27-hexafluro-cholecalciferol] repressed CD44 expression in MCF10DCIS.com basal-like human breast cancer cells and inhibited MCF10DCIS xenograft tumor growth. Vitamin D 54-63 CD44 molecule (Indian blood group) Homo sapiens 206-210 23326564-4 2013 METHODS AND FINDINGS: The treatment with Gemini vitamin D BXL0124 decreased CD44 protein level, suppressed STAT3 signaling, and inhibited invasion and proliferation of MCF10DCIS cells. Vitamin D 48-57 CD44 molecule (Indian blood group) Homo sapiens 76-80 23326564-12 2013 It also suggests that repression of CD44-STAT3 signaling is a key molecular mechanism in the inhibition of breast cancer invasion by the Gemini vitamin D analog BXL0124. Vitamin D 144-153 CD44 molecule (Indian blood group) Homo sapiens 36-40 24455835-6 2013 Disturbances of vitamin D target pathway can be genetically conditioned, hence the aim of this paper is to describe the distribution of polymorphic variants of vitamin D-binding protein gene (VDBP), vitamin D receptor gene (VDR) and gene of the calcium-sensing receptor (CaSR) with respect to PTH concentrations in serum and response to cinacalcet treatment in patients with secondary hyperparathyroidism in view of the differences in demographical, clinical and laboratory data of the dialysed patients. Vitamin D 16-25 GC vitamin D binding protein Homo sapiens 192-196 24455835-6 2013 Disturbances of vitamin D target pathway can be genetically conditioned, hence the aim of this paper is to describe the distribution of polymorphic variants of vitamin D-binding protein gene (VDBP), vitamin D receptor gene (VDR) and gene of the calcium-sensing receptor (CaSR) with respect to PTH concentrations in serum and response to cinacalcet treatment in patients with secondary hyperparathyroidism in view of the differences in demographical, clinical and laboratory data of the dialysed patients. Vitamin D 16-25 vitamin D receptor Homo sapiens 199-217 24455835-6 2013 Disturbances of vitamin D target pathway can be genetically conditioned, hence the aim of this paper is to describe the distribution of polymorphic variants of vitamin D-binding protein gene (VDBP), vitamin D receptor gene (VDR) and gene of the calcium-sensing receptor (CaSR) with respect to PTH concentrations in serum and response to cinacalcet treatment in patients with secondary hyperparathyroidism in view of the differences in demographical, clinical and laboratory data of the dialysed patients. Vitamin D 16-25 vitamin D receptor Homo sapiens 224-227 23074218-0 2012 Vitamin D up-regulates glucose transporter 4 (GLUT4) translocation and glucose utilization mediated by cystathionine-gamma-lyase (CSE) activation and H2S formation in 3T3L1 adipocytes. Vitamin D 0-9 cystathionine gamma-lyase Homo sapiens 103-128 23074218-0 2012 Vitamin D up-regulates glucose transporter 4 (GLUT4) translocation and glucose utilization mediated by cystathionine-gamma-lyase (CSE) activation and H2S formation in 3T3L1 adipocytes. Vitamin D 0-9 cystathionine gamma-lyase Homo sapiens 130-133 23217254-2 2012 With emphasis on human metabolism, we critically review current data, and propose that--although a number of questions remain--circulating FGF23 is pivotal in the control of phosphate and vitamin D metabolism, and may have additional systemic effects, particularly in chronic kidney disease; that FGF19 signaling is important for the regulation of bile acid metabolism, whereas its physiological role in promoting glucose and lipid metabolism is less well understood; and that the physiological role of circulating FGF21 in metabolic homeostasis warrants further investigation. Vitamin D 188-197 fibroblast growth factor 23 Homo sapiens 139-144 22610818-7 2012 Herein we demonstrate that although the vitamin D receptor (VDR) is present in both IBC and non-IBC cell lines, the effect of vitamin D treatment is significant only on the IBC cells. Vitamin D 40-49 vitamin D receptor Homo sapiens 60-63 23108197-5 2012 Iron deficiency may affect autosomal dominant hypophosphatemic rickets phenotype by regulating FGF23 production.Current treatment with activated vitamin D metabolites and oral inorganic phosphate salts may partially correct skeletal lesions and linear growth in patients with hypophosphatemic rickets. Vitamin D 145-154 fibroblast growth factor 23 Homo sapiens 95-100 22358381-1 2012 We aimed to study Th1/Th2 cell balance by measuring the levels of cytokines IL-4, IL-10, and IFN-gamma, which play an important role in the immune response of patients with allergic rhinitis and/or nasal polyps, and determine the correlation between Th1/Th2 cell balance and 1alpha,25-dihydroxyvitamin D(3), an active metabolite of vitamin D. Vitamin D 294-303 negative elongation factor complex member C/D Homo sapiens 18-21 22457344-3 2012 After 15 weeks of vitamin D supplementation, serum 25(OH) vitamin D levels rose significantly from baseline, with a corresponding increase in IL-10 production by peripheral blood mononuclear cells and a reduced frequency of Th17 cells. Vitamin D 18-27 interleukin 10 Homo sapiens 142-147 23206285-2 2012 The active form of vitamin D, 1alpha,25(OH(2) )D(3) , targets the wnt/beta-catenin pathway by upregulating key tumor suppressor genes such as E-cadherin, which promotes an epithelial phenotype, but this is only possible when the vitamin D receptor (VDR) is present. Vitamin D 19-28 vitamin D receptor Homo sapiens 229-247 23206285-2 2012 The active form of vitamin D, 1alpha,25(OH(2) )D(3) , targets the wnt/beta-catenin pathway by upregulating key tumor suppressor genes such as E-cadherin, which promotes an epithelial phenotype, but this is only possible when the vitamin D receptor (VDR) is present. Vitamin D 19-28 vitamin D receptor Homo sapiens 249-252 23055531-5 2012 A functional vitamin D response element was defined in the 5-prime regulatory region of the miR-498 genome, which is occupied by the vitamin D receptor and its coactivators. Vitamin D 13-22 vitamin D receptor Homo sapiens 133-151 23112173-10 2012 Thus, 1,25D and the VDR regulate the c-MYC/MXD1 network to suppress c-MYC function, providing a molecular basis for cancer preventive actions of vitamin D. Vitamin D 145-154 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 20-23 22610885-1 2012 Vitamin D binding protein (GC) gene polymorphisms are known to influence vitamin D levels. Vitamin D 73-82 GC vitamin D binding protein Homo sapiens 0-25 22917542-2 2012 Vitamin D exerts its effects through vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 37-55 22917542-2 2012 Vitamin D exerts its effects through vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 57-60 22927052-5 2012 Upon infection, intracellular levels of DeltaphoPQ, DeltapmrAB, and PhoP(c) S. Typhi decreased over time but were not further inhibited by the vitamin D(3)-induced increase in camp expression. Vitamin D 143-152 cathelicidin antimicrobial peptide Mus musculus 176-180 22739976-1 2012 Progressive elevations of fibroblastic growth factor 23 (FGF23) in chronic kidney disease may reduce serum 25-hydroxyvitamin D (25(OH)) and 1,25-dihydroxyvitamin D (1,25(OH)(2)D) levels, via stimulation of 24-hydroxylase (Cyp24a1)-mediated catabolism of these vitamin D metabolites. Vitamin D 117-126 fibroblast growth factor 23 Homo sapiens 26-55 22739976-1 2012 Progressive elevations of fibroblastic growth factor 23 (FGF23) in chronic kidney disease may reduce serum 25-hydroxyvitamin D (25(OH)) and 1,25-dihydroxyvitamin D (1,25(OH)(2)D) levels, via stimulation of 24-hydroxylase (Cyp24a1)-mediated catabolism of these vitamin D metabolites. Vitamin D 117-126 fibroblast growth factor 23 Homo sapiens 57-62 22739976-4 2012 The FGF23-dependent increase in Cyp24a1 mRNA expression in the mouse kidneys was consistent with the possibility that FGF23 induces vitamin D catabolism. Vitamin D 132-141 fibroblast growth factor 23 Mus musculus 4-9 22739976-4 2012 The FGF23-dependent increase in Cyp24a1 mRNA expression in the mouse kidneys was consistent with the possibility that FGF23 induces vitamin D catabolism. Vitamin D 132-141 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 32-39 22739976-4 2012 The FGF23-dependent increase in Cyp24a1 mRNA expression in the mouse kidneys was consistent with the possibility that FGF23 induces vitamin D catabolism. Vitamin D 132-141 fibroblast growth factor 23 Mus musculus 118-123 23111742-5 2012 It is suggested that polymorphisms and haplotypes in the VDR gene may explain the differences in response to vitamin D therapy. Vitamin D 109-118 vitamin D receptor Homo sapiens 57-60 23111742-7 2012 The Fok I, Bsm I, Apa I and Taq I polymorphisms were examined by PCR-RFLP, and 50 subjects received vitamin D therapy to evaluate the association between VDR gene polymorphisms and response to vitamin D therapy. Vitamin D 193-202 vitamin D receptor Homo sapiens 154-157 22930691-1 2012 Dentin matrix protein-1 (DMP1) or phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX) inactivation results in elevation of the phosphaturic hormone fibroblast growth factor (FGF)-23, leading to hypophosphatemia, aberrant vitamin D metabolism, and rickets/osteomalacia. Vitamin D 256-265 fibroblast growth factor 23 Mus musculus 183-216 23236317-1 2012 BACKGROUND: Vitamin D can translocate a vitamin D receptor (VDR) from the nucleus to the cell membranes. Vitamin D 12-21 vitamin D receptor Homo sapiens 40-58 23236317-1 2012 BACKGROUND: Vitamin D can translocate a vitamin D receptor (VDR) from the nucleus to the cell membranes. Vitamin D 12-21 vitamin D receptor Homo sapiens 60-63 23236317-12 2012 CONCLUSION: CSE has an ability to inhibit vitamin D-induced VDR translocation, but MAPKs are not involved in this inhibition. Vitamin D 42-51 vitamin D receptor Homo sapiens 60-63 23146737-0 2012 [Expression of RANTES in the lung tissue of asthmatic rats, and the intervention effect of vitamin D on RANTES expression]. Vitamin D 91-100 C-C motif chemokine ligand 5 Rattus norvegicus 104-110 23146737-1 2012 OBJECTIVE: To investigate the effect of vitamin D on the expression of chemokine regulated on activation, normal T cells expressed and secreted (RANTES) in the lung tissue of asthmatic rats, and the role of vitamin D in the control of asthmatic airway inflammation and the synergistic action of hormones. Vitamin D 40-49 C-C motif chemokine ligand 5 Rattus norvegicus 145-151 23146737-9 2012 Protein expression of RANTES in the lung tissue and BALF was significantly higher in the asthma group than in the normal control group (P<0.05), while it was lower in the intervention groups than in the asthma group, exhibiting significant differences between each intervention group and the asthma group (P<0.05) (except the difference in protein expression of RANTES in BALF between the vitamin D intervention and asthma groups). Vitamin D 395-404 C-C motif chemokine ligand 5 Rattus norvegicus 22-28 23146737-10 2012 The budesonide+vitamin D intervention group showed less protein expression of RANTES in the lung tissue and BALF than both the budesonide intervention and vitamin D intervention groups (P<0.05). Vitamin D 15-24 C-C motif chemokine ligand 5 Rattus norvegicus 78-84 23146737-12 2012 The budesonide+vitamin D intervention group showed the lowest level of RANTES mRNA, with no significant difference from the normal control group. Vitamin D 15-24 C-C motif chemokine ligand 5 Rattus norvegicus 71-77 23146737-14 2012 Vitamin D intervention can decrease the expression of RANTES, suggesting that vitamin D can reduce airway inflammation by regulating the expression of RANTES. Vitamin D 0-9 C-C motif chemokine ligand 5 Rattus norvegicus 54-60 23146737-14 2012 Vitamin D intervention can decrease the expression of RANTES, suggesting that vitamin D can reduce airway inflammation by regulating the expression of RANTES. Vitamin D 0-9 C-C motif chemokine ligand 5 Rattus norvegicus 151-157 23146737-14 2012 Vitamin D intervention can decrease the expression of RANTES, suggesting that vitamin D can reduce airway inflammation by regulating the expression of RANTES. Vitamin D 78-87 C-C motif chemokine ligand 5 Rattus norvegicus 54-60 23146737-14 2012 Vitamin D intervention can decrease the expression of RANTES, suggesting that vitamin D can reduce airway inflammation by regulating the expression of RANTES. Vitamin D 78-87 C-C motif chemokine ligand 5 Rattus norvegicus 151-157 23146737-15 2012 Vitamin D can be used together with budesonide to further decrease the mRNA and protein expression of RANTES. Vitamin D 0-9 C-C motif chemokine ligand 5 Rattus norvegicus 102-108 22892281-2 2012 Most known effects of vitamin D are mediated via the vitamin D receptor (VDR). Vitamin D 22-31 vitamin D receptor Homo sapiens 53-71 22892281-2 2012 Most known effects of vitamin D are mediated via the vitamin D receptor (VDR). Vitamin D 22-31 vitamin D receptor Homo sapiens 73-76 23246677-1 2012 Vitamin D receptor (VDR) is found in most tissues, not just those participating in the classic actions of vitamin D such as bone, gut, and kidney. Vitamin D 106-115 vitamin D receptor Homo sapiens 0-18 23246677-1 2012 Vitamin D receptor (VDR) is found in most tissues, not just those participating in the classic actions of vitamin D such as bone, gut, and kidney. Vitamin D 106-115 vitamin D receptor Homo sapiens 20-23 22103239-1 2012 UNLABELLED: Fibroblast growth factor-23 (FGF23) is a hormonal regulator of circulating phosphate and vitamin D levels. Vitamin D 101-110 fibroblast growth factor 23 Homo sapiens 12-39 22103239-1 2012 UNLABELLED: Fibroblast growth factor-23 (FGF23) is a hormonal regulator of circulating phosphate and vitamin D levels. Vitamin D 101-110 fibroblast growth factor 23 Homo sapiens 41-46 22457088-14 2012 CONCLUSION: Vitamin D deficiency in HD patients who had not taken vitamin D receptor agonist (VDRA) is associated with an increased risk of all-cause mortality. Vitamin D 12-21 vitamin D receptor Homo sapiens 66-84 23023636-2 2012 FGF23 exerts its effects in kidney by decreasing both renal phosphate (Pi) reabsorption and vitamin D activation. Vitamin D 92-101 fibroblast growth factor 23 Homo sapiens 0-5 23023636-4 2012 Circulating level of FGF23 appears to be regulated by systemic factors as well, including vitamin D and PTH. Vitamin D 90-99 fibroblast growth factor 23 Homo sapiens 21-26 22692397-2 2012 Numerous genes have been linked to the emergence of SLE, including vitamin D receptor (VDR) gene that synthesizes the receptor of vitamin D. Vitamin D 67-76 vitamin D receptor Homo sapiens 87-90 22692397-4 2012 Vitamin D"s biological functions are mediated by VDR. Vitamin D 0-9 vitamin D receptor Homo sapiens 49-52 22692397-8 2012 In this article, we review the aspects related to the metabolism and immunoregulatory effects of vitamin D, VDR, and main polymorphisms involving the VDR gene and the relationship between vitamin D levels and its receptor with SLE. Vitamin D 188-197 vitamin D receptor Homo sapiens 150-153 22664272-9 2012 Furthermore, strong VDR expression in Barrett"s mucosa may indicate an increased sensitivity of this tissue to endogenous or therapeutic effects of Vitamin D. Vitamin D 148-157 vitamin D receptor Homo sapiens 20-23 23450267-1 2012 The bioactive form of vitamin D, 1alpha, 25-dihydroxyvitamin D3 (1alpha, 25(OH)2D3), is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the nuclear receptor super-family expressed in many cell types, and modulates a variety of biological functions. Vitamin D 22-31 vitamin D receptor Homo sapiens 128-146 23450267-1 2012 The bioactive form of vitamin D, 1alpha, 25-dihydroxyvitamin D3 (1alpha, 25(OH)2D3), is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the nuclear receptor super-family expressed in many cell types, and modulates a variety of biological functions. Vitamin D 22-31 vitamin D receptor Homo sapiens 148-151 22878961-1 2012 Renal Klotho controls mineral metabolism by directly modulating tubular reabsorption of phosphate and calcium and by acting as a co-receptor for the phosphaturic and vitamin D-regulating hormone fibroblast growth factor-23 (FGF23). Vitamin D 166-175 klotho Mus musculus 6-12 22878961-1 2012 Renal Klotho controls mineral metabolism by directly modulating tubular reabsorption of phosphate and calcium and by acting as a co-receptor for the phosphaturic and vitamin D-regulating hormone fibroblast growth factor-23 (FGF23). Vitamin D 166-175 fibroblast growth factor 23 Mus musculus 195-222 22878961-1 2012 Renal Klotho controls mineral metabolism by directly modulating tubular reabsorption of phosphate and calcium and by acting as a co-receptor for the phosphaturic and vitamin D-regulating hormone fibroblast growth factor-23 (FGF23). Vitamin D 166-175 fibroblast growth factor 23 Mus musculus 224-229 22855339-1 2012 CONTEXT: Inherited forms of vitamin D deficiency are rare causes of rickets and to date have been traced to mutations in three genes, VDR, encoding the 1alpha,25-dihydroxyvitamin D receptor, CYP27B1, encoding the vitamin D 1alpha-hydroxylase, and CYP2R1, encoding a microsomal vitamin D 25-hydroxylase. Vitamin D 28-37 vitamin D receptor Homo sapiens 134-137 22842395-1 2012 Vitamin D plays an important role in neurodegenerative disorders as a crucial neuro-immunomodulator, and accumulating data have provided evidence for that vitamin D receptor (VDR) gene is a candidate gene for susceptibility to Parkinson"s disease (PD). Vitamin D 0-9 vitamin D receptor Homo sapiens 155-173 22842395-1 2012 Vitamin D plays an important role in neurodegenerative disorders as a crucial neuro-immunomodulator, and accumulating data have provided evidence for that vitamin D receptor (VDR) gene is a candidate gene for susceptibility to Parkinson"s disease (PD). Vitamin D 0-9 vitamin D receptor Homo sapiens 175-178 22751936-7 2012 At first, possible differences in the expression of CYP24A1, a major catabolizing enzyme for vitamin D compounds and resulting differences in the degradation of analogs were investigated. Vitamin D 105-114 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 64-71 22993666-1 2012 AIM: To assess vitamin D in hepatitis C patients and its relationship to interleukin (IL)-23, IL-17, and macrophage chemoattractant protein-1 (MCP-1). Vitamin D 15-24 interleukin 17A Homo sapiens 94-99 22993666-20 2012 IL-23, IL-17, and MCP-1 were markedly increased in HCV-infected patients in comparison to controls.A significant negative correlation between vitamin D and IL-17 and -23 and MCP-1 was detected. Vitamin D 142-151 interleukin 17A Homo sapiens 156-169 22648952-10 2012 We found that expression of VDR and CYP27B1 increased significantly at day 7 of regeneration, and these results confirm the expression of Vdr and Cyp27b1 in vivo and suggest a potential role for vitamin D(3) in skeletal muscle regeneration following injury. Vitamin D 195-204 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 28-31 22703926-13 2012 CONCLUSIONS: FGF-23, a hormone involved in phosphorous and vitamin D homeostasis, is independently associated with all-cause death and incident HF in community-living older persons. Vitamin D 59-68 fibroblast growth factor 23 Homo sapiens 13-19 22801813-0 2012 The GC, CYP2R1 and DHCR7 genes are associated with vitamin D levels in northeastern Han Chinese children. Vitamin D 51-60 7-dehydrocholesterol reductase Homo sapiens 19-24 22801813-3 2012 Our objective was to identify the relationship among three vitamin D-related genes (GC, CYP2R1 and DHCR7/NADSYN1) and the levels of 25(OH)D in northeastern Han Chinese children. Vitamin D 59-68 7-dehydrocholesterol reductase Homo sapiens 99-104 22801813-3 2012 Our objective was to identify the relationship among three vitamin D-related genes (GC, CYP2R1 and DHCR7/NADSYN1) and the levels of 25(OH)D in northeastern Han Chinese children. Vitamin D 59-68 NAD synthetase 1 Homo sapiens 105-112 22085499-2 2012 The vitamin D receptor (VDR) is highly expressed in epithelial cells at risk for carcinogenesis including those resident in skin, breast, prostate and colon, providing a direct molecular link by which vitamin D status impacts on carcinogenesis. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 22085499-7 2012 Because VDR expression is retained in many human tumors, vitamin D status may be an important modulator of cancer progression in persons living with cancer. Vitamin D 57-66 vitamin D receptor Homo sapiens 8-11 22484315-1 2012 Vitamin D, whose levels vary seasonally with sunlight, is activated to 1alpha,25-dihydroxyvitamin D(3) that binds the vitamin D receptor (VDR) and transcriptionally regulates intestinal CYP3A4 expression. Vitamin D 0-9 vitamin D receptor Homo sapiens 118-136 22484315-1 2012 Vitamin D, whose levels vary seasonally with sunlight, is activated to 1alpha,25-dihydroxyvitamin D(3) that binds the vitamin D receptor (VDR) and transcriptionally regulates intestinal CYP3A4 expression. Vitamin D 0-9 vitamin D receptor Homo sapiens 138-141 22541691-0 2012 The pan-caspase inhibitor Q-VD-OPh has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells. Vitamin D 83-92 mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens 113-117 22474172-8 2012 This VDRE served as a strong binding site for the recombinant VDR-RXRalpha heterodimers in vitro and was potently activated by VDR in the presence of vitamin D(3) in heterologous promoter assays. Vitamin D 150-159 vitamin D receptor Homo sapiens 5-8 22474172-8 2012 This VDRE served as a strong binding site for the recombinant VDR-RXRalpha heterodimers in vitro and was potently activated by VDR in the presence of vitamin D(3) in heterologous promoter assays. Vitamin D 150-159 retinoid X receptor alpha Homo sapiens 66-74 22474172-8 2012 This VDRE served as a strong binding site for the recombinant VDR-RXRalpha heterodimers in vitro and was potently activated by VDR in the presence of vitamin D(3) in heterologous promoter assays. Vitamin D 150-159 vitamin D receptor Homo sapiens 62-65 22474172-11 2012 We showed that expression of the SLCO1A2 gene is induced by vitamin D(3) at the transcriptional level through the VDR. Vitamin D 60-69 vitamin D receptor Homo sapiens 114-117 22754549-1 2012 CIRCULATING CALCIUM AND PHOSPHATE ARE TIGHTLY REGULATED BY THREE HORMONES: the active form of vitamin D (1,25-dihydroxyvitamin D), fibroblast growth factor (FGF)-23, and parathyroid hormone (PTH). Vitamin D 94-103 fibroblast growth factor 23 Homo sapiens 131-164 22414425-6 2012 In keratinocyte cell cultures, the ligand-conjugated liposomes loaded with the vitamin D(3) analogue calcipotriol induced transcription of the gene encoding the antimicrobial peptide cathelicidin, which is activated through the vitamin D(3) receptor upon binding of vitamin D(3) analogues. Vitamin D 79-88 vitamin D receptor Homo sapiens 228-249 22676419-6 2012 Most of vitamin D biological actions are mediated by the vitamin D receptor and the synthesis and catabolism of this hormone are regulated by the enzymes CYP27B1 and CYP24A1. Vitamin D 8-17 vitamin D receptor Homo sapiens 57-75 22676419-6 2012 Most of vitamin D biological actions are mediated by the vitamin D receptor and the synthesis and catabolism of this hormone are regulated by the enzymes CYP27B1 and CYP24A1. Vitamin D 8-17 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 166-173 22328083-2 2012 The active vitamin D metabolite 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) regulates gene transcription via its nuclear receptor (VDR), and posttranscriptional regulatory mechanisms of gene expression have also been proposed. Vitamin D 11-20 vitamin D receptor Homo sapiens 137-140 22174178-5 2012 The PMA enhancing effect on 1,25(OH)(2)D(3) action was evident in a minimal promoter with three osteocalcin VDREs and was reduced after mutation of a putative vitamin D stimulatory site in the hCYP24A1 promoter. Vitamin D 159-168 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 193-201 22247037-1 2012 Fibroblast growth factor-23 (FGF23) is a phosphate- and vitamin D-regulating hormone derived from osteoblasts/osteocytes that circulates in both active (intact, iFGF23) and inactive (C-terminal, cFGF23) forms. Vitamin D 56-65 fibroblast growth factor 23 Homo sapiens 0-27 22247037-1 2012 Fibroblast growth factor-23 (FGF23) is a phosphate- and vitamin D-regulating hormone derived from osteoblasts/osteocytes that circulates in both active (intact, iFGF23) and inactive (C-terminal, cFGF23) forms. Vitamin D 56-65 fibroblast growth factor 23 Homo sapiens 29-34 22311183-7 2012 Plasma levels of alpha-1 antitrypsin isotypes 2-5, apolipoprotein A-IV, and vitamin D-binding protein isotypes 1 and 2 were significantly reduced in BRCA1 mutation carriers with respect to non-mutant controls. Vitamin D 76-85 BRCA1 DNA repair associated Homo sapiens 149-154 22341429-2 2012 In the present study we evaluated whether vitamin D would have antiproliferative or cytotoxic effects on human pre-B acute lymphoblastic leukemia cells. Vitamin D 42-51 prolactin regulatory element binding Homo sapiens 111-116 22025115-8 2012 RRF, serum phosphorus and calcium levels and active vitamin D therapy explain 69% of the variation in FGF-23. Vitamin D 52-61 fibroblast growth factor 23 Homo sapiens 102-108 21390563-1 2012 Fibroblast growth factor 23 (FGF23) is a novel hormone produced by bone with known functions to regulate urinary phosphate excretion, as well as vitamin D and PTH production. Vitamin D 145-154 fibroblast growth factor 23 Homo sapiens 0-27 21390563-1 2012 Fibroblast growth factor 23 (FGF23) is a novel hormone produced by bone with known functions to regulate urinary phosphate excretion, as well as vitamin D and PTH production. Vitamin D 145-154 fibroblast growth factor 23 Homo sapiens 29-34 22421156-0 2012 Dual role of hematopoietic progenitor kinase 1 (HPK1) as a positive regulator of 1alpha,25-dihydroxyvitamin D-induced differentiation and cell cycle arrest of AML cells and as a mediator of vitamin D resistance. Vitamin D 100-109 mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens 13-46 22421156-0 2012 Dual role of hematopoietic progenitor kinase 1 (HPK1) as a positive regulator of 1alpha,25-dihydroxyvitamin D-induced differentiation and cell cycle arrest of AML cells and as a mediator of vitamin D resistance. Vitamin D 100-109 mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens 48-52 22421156-5 2012 To explain why 40AF and the intrinsically vitamin D-resistant KG-1a cells can proliferate in the presence of vitamin D, we found that the cleaved HPK1 fragment (HPK1-C) level is high in 40AF and KG-1a cells, but when differentiation is induced by DCS, HPK1-C decreases while full-length (FL)-HPK1 increases. Vitamin D 42-51 mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens 146-150 22421156-5 2012 To explain why 40AF and the intrinsically vitamin D-resistant KG-1a cells can proliferate in the presence of vitamin D, we found that the cleaved HPK1 fragment (HPK1-C) level is high in 40AF and KG-1a cells, but when differentiation is induced by DCS, HPK1-C decreases while full-length (FL)-HPK1 increases. Vitamin D 42-51 mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens 161-165 22421156-5 2012 To explain why 40AF and the intrinsically vitamin D-resistant KG-1a cells can proliferate in the presence of vitamin D, we found that the cleaved HPK1 fragment (HPK1-C) level is high in 40AF and KG-1a cells, but when differentiation is induced by DCS, HPK1-C decreases while full-length (FL)-HPK1 increases. Vitamin D 42-51 mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens 161-165 22421156-5 2012 To explain why 40AF and the intrinsically vitamin D-resistant KG-1a cells can proliferate in the presence of vitamin D, we found that the cleaved HPK1 fragment (HPK1-C) level is high in 40AF and KG-1a cells, but when differentiation is induced by DCS, HPK1-C decreases while full-length (FL)-HPK1 increases. Vitamin D 109-118 mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens 146-150 22421156-5 2012 To explain why 40AF and the intrinsically vitamin D-resistant KG-1a cells can proliferate in the presence of vitamin D, we found that the cleaved HPK1 fragment (HPK1-C) level is high in 40AF and KG-1a cells, but when differentiation is induced by DCS, HPK1-C decreases while full-length (FL)-HPK1 increases. Vitamin D 109-118 mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens 161-165 22421156-5 2012 To explain why 40AF and the intrinsically vitamin D-resistant KG-1a cells can proliferate in the presence of vitamin D, we found that the cleaved HPK1 fragment (HPK1-C) level is high in 40AF and KG-1a cells, but when differentiation is induced by DCS, HPK1-C decreases while full-length (FL)-HPK1 increases. Vitamin D 109-118 mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens 161-165 22421156-7 2012 The results indicate that FL-HPK1 is a positive regulator of vitamin D-induced differentiation in AML cells, but the cleaved HPK1 fragment inhibits differentiation. Vitamin D 61-70 mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens 29-33 22421156-8 2012 Thus, high HPK1 cleavage activity contributes to vitamin D resistance, and HPK1 has a dual role in AML cell differentiation. Vitamin D 49-58 mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens 11-15 22294750-1 2012 It is still controversial whether the bone-derived hormone fibroblast growth factor-23 (FGF23) has additional physiological functions apart from its well-known suppressive actions on renal phosphate reabsorption and vitamin D hormone synthesis. Vitamin D 216-225 fibroblast growth factor 23 Mus musculus 59-86 22294750-1 2012 It is still controversial whether the bone-derived hormone fibroblast growth factor-23 (FGF23) has additional physiological functions apart from its well-known suppressive actions on renal phosphate reabsorption and vitamin D hormone synthesis. Vitamin D 216-225 fibroblast growth factor 23 Mus musculus 88-93 22449247-1 2012 INTRODUCTION: In the past years, the biologically active form of vitamin D(3), 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), has received large appreciation due to the broad physiological impact of the hormone and its nuclear receptor, the transcription factor vitamin D receptor (VDR). Vitamin D 65-74 vitamin D receptor Homo sapiens 271-289 22449247-1 2012 INTRODUCTION: In the past years, the biologically active form of vitamin D(3), 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), has received large appreciation due to the broad physiological impact of the hormone and its nuclear receptor, the transcription factor vitamin D receptor (VDR). Vitamin D 65-74 vitamin D receptor Homo sapiens 291-294 22130326-5 2012 The second SNP, rs12785878, is located near DHCR7 (Chr11), a genetic determinant of vitamin D insufficiency, and showed a size effect in MS similar to that recently observed in Type 1 diabetes (T1D; OR = 1.10; P = 0.009). Vitamin D 84-93 7-dehydrocholesterol reductase Homo sapiens 44-49 22047708-0 2012 Vitamin D insufficiency predicts time to first treatment (TFT) in early chronic lymphocytic leukemia (CLL). Vitamin D 0-9 T-box transcription factor T Homo sapiens 58-61 22047708-5 2012 A patient stratification according to these 3 groups led to significant difference in terms of TFT, with vitamin D insufficient patients having the shortest TFT (P=0.02). Vitamin D 105-114 T-box transcription factor T Homo sapiens 95-98 22047708-5 2012 A patient stratification according to these 3 groups led to significant difference in terms of TFT, with vitamin D insufficient patients having the shortest TFT (P=0.02). Vitamin D 105-114 T-box transcription factor T Homo sapiens 157-160 22065093-1 2012 OBJECTIVES: To identify relationships between vitamin D serum levels and the presence of autoantibodies directed against vitamin D and levels of interleukin(IL)-17 and IL-23 in patients with systemic lupus erythematosus (SLE). Vitamin D 46-55 interleukin 17A Homo sapiens 145-163 22322599-5 2012 The protective effects of 1,25-(OH)(2)D(3) against thymine dimers were abolished in fibroblasts from patients with hereditary vitamin D-resistant rickets that expressed no VDR protein, indicating that the VDR is essential for photoprotection. Vitamin D 126-135 vitamin D receptor Homo sapiens 205-208 22322599-6 2012 Photoprotection remained in hereditary vitamin D-resistant rickets fibroblasts expressing a VDR with a defective DNA-binding domain or a mutation in helix H1 of the classical ligand-binding domain, both defects resulting in a failure to mediate genomic responses, implicating nongenomic responses for photoprotection. Vitamin D 39-48 vitamin D receptor Homo sapiens 92-95 21929372-1 2012 SIGNIFICANCE: The thioredoxin-interacting protein (TXNIP, also termed VDUP1 for vitamin D upregulated protein or TBP2 for thioredoxin-binding protein) was originally discovered by virtue of its strong regulation by vitamin D. Vitamin D 80-89 thioredoxin 1 Mus musculus 18-29 21929372-1 2012 SIGNIFICANCE: The thioredoxin-interacting protein (TXNIP, also termed VDUP1 for vitamin D upregulated protein or TBP2 for thioredoxin-binding protein) was originally discovered by virtue of its strong regulation by vitamin D. Vitamin D 80-89 thioredoxin 1 Mus musculus 122-133 21929372-1 2012 SIGNIFICANCE: The thioredoxin-interacting protein (TXNIP, also termed VDUP1 for vitamin D upregulated protein or TBP2 for thioredoxin-binding protein) was originally discovered by virtue of its strong regulation by vitamin D. Vitamin D 215-224 thioredoxin 1 Mus musculus 18-29 21929372-1 2012 SIGNIFICANCE: The thioredoxin-interacting protein (TXNIP, also termed VDUP1 for vitamin D upregulated protein or TBP2 for thioredoxin-binding protein) was originally discovered by virtue of its strong regulation by vitamin D. Vitamin D 215-224 thioredoxin 1 Mus musculus 122-133 22370611-0 2012 Vitamin D deficiency is associated with increased IL-17 and TNFalpha levels in patients with chronic heart failure. Vitamin D 0-9 interleukin 17A Homo sapiens 50-55 23814529-2 2012 Vitamin D receptor (VDR), a nuclear receptor, mediates the biological functions of vitamin D. Vitamin D 83-92 vitamin D receptor Homo sapiens 0-18 23814529-2 2012 Vitamin D receptor (VDR), a nuclear receptor, mediates the biological functions of vitamin D. Vitamin D 83-92 vitamin D receptor Homo sapiens 20-23 21898178-1 2012 Fibroblast growth factor 23 (FGF23) is a hormone regulating phosphate and vitamin D metabolism. Vitamin D 74-83 fibroblast growth factor 23 Homo sapiens 0-27 21898178-1 2012 Fibroblast growth factor 23 (FGF23) is a hormone regulating phosphate and vitamin D metabolism. Vitamin D 74-83 fibroblast growth factor 23 Homo sapiens 29-34 26889405-6 2012 VDR activation using newer agents including vitamin D mimetics (such as paricalcitol and maxacalcitol) are promising agents, which may be related to their selectivity in activating VDR by means of attracting different post-D-complex cofactors. Vitamin D 44-53 vitamin D receptor Homo sapiens 0-3 26889405-6 2012 VDR activation using newer agents including vitamin D mimetics (such as paricalcitol and maxacalcitol) are promising agents, which may be related to their selectivity in activating VDR by means of attracting different post-D-complex cofactors. Vitamin D 44-53 vitamin D receptor Homo sapiens 181-184 21871642-1 2012 The objectives of the study were to determine associations between single nucleotide polymorphisms (SNPs) of the vitamin D receptor (VDR) gene and insulin resistance and the effects of these SNPs on changes in insulin sensitivity in response to vitamin D supplementation. Vitamin D 113-122 vitamin D receptor Homo sapiens 133-136 21871642-9 2012 This study has highlighted the association of vitamin D responsiveness and insulin resistance with VDR gene polymorphisms. Vitamin D 46-55 vitamin D receptor Homo sapiens 99-102 21871642-11 2012 Genotyping of the VDR gene may provide a predictive measure for insulin resistance in response to vitamin D intervention. Vitamin D 98-107 vitamin D receptor Homo sapiens 18-21 22193171-1 2012 The anticarcinogenic potential of vitamin D might be mediated by not only calcium metabolism but also other mechanisms initiated by vitamin D receptor (VDR). Vitamin D 34-43 vitamin D receptor Homo sapiens 132-150 22193171-1 2012 The anticarcinogenic potential of vitamin D might be mediated by not only calcium metabolism but also other mechanisms initiated by vitamin D receptor (VDR). Vitamin D 34-43 vitamin D receptor Homo sapiens 152-155 22144504-0 2012 Polymorphic variation in the GC and CASR genes and associations with vitamin D metabolite concentration and metachronous colorectal neoplasia. Vitamin D 69-78 GC vitamin D binding protein Homo sapiens 29-31 22144504-2 2012 This study evaluated associations between polymorphic variation in the Gc-globulin (GC) and calcium-sensing receptor (CASR) and odds for metachronous colorectal neoplasia and vitamin D metabolite concentrations. Vitamin D 175-184 GC vitamin D binding protein Homo sapiens 71-82 22144504-2 2012 This study evaluated associations between polymorphic variation in the Gc-globulin (GC) and calcium-sensing receptor (CASR) and odds for metachronous colorectal neoplasia and vitamin D metabolite concentrations. Vitamin D 175-184 GC vitamin D binding protein Homo sapiens 84-86 22293059-15 2012 Furthermore, we found baseline FGF23 to predict PTH levels after 16 weeks of vitamin D analog treatment. Vitamin D 77-86 fibroblast growth factor 23 Homo sapiens 31-36 22227726-6 2012 Zip code of residence was used to evaluate potential for skin production of vitamin D. Vitamin D 76-85 death associated protein kinase 3 Homo sapiens 0-3 22121948-8 2012 The relationship between FGF23 and serum vitamin D needs further evaluation. Vitamin D 41-50 fibroblast growth factor 23 Homo sapiens 25-30 22133546-1 2012 Selective inhibitors of CYP24A1 represent an important synthetic target in a search for novel vitamin D compounds of therapeutic value. Vitamin D 94-103 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 24-31 22179700-1 2012 Transcription regulation by steroid hormones and other metabolites is mediated by nuclear receptors (NRs) such as the vitamin D and retinoid X receptors (VDR and RXR). Vitamin D 118-127 vitamin D receptor Homo sapiens 154-157 22396160-4 2012 FGF23 is secreted from bone and acts on kidney to inhibit phosphate reabsorption and vitamin D synthesis. Vitamin D 85-94 fibroblast growth factor 23 Homo sapiens 0-5 22396161-1 2012 Fibroblast growth factor 23 (FGF23) is part of a previously unrecognized hormonal bone-parathyroid-kidney axis, which is modulated by 1,25(OH)(2)-vitamin D (1,25(OH)(2)D), dietary and circulating phosphate and possibly PTH. Vitamin D 146-155 fibroblast growth factor 23 Homo sapiens 0-27 22396161-1 2012 Fibroblast growth factor 23 (FGF23) is part of a previously unrecognized hormonal bone-parathyroid-kidney axis, which is modulated by 1,25(OH)(2)-vitamin D (1,25(OH)(2)D), dietary and circulating phosphate and possibly PTH. Vitamin D 146-155 fibroblast growth factor 23 Homo sapiens 29-34 22396162-0 2012 Evidence for FGF23 involvement in a bone-kidney axis regulating bone mineralization and systemic phosphate and vitamin D homeostasis. Vitamin D 111-120 fibroblast growth factor 23 Homo sapiens 13-18 22396162-3 2012 In addition, FGF23 production is regulated by 1,25(OH)2D in a feedback loop where FGF23 stimulate Cyp24 mediated degradation of 1,25(OH)2D that serves to protect the organism from the toxic effects of vitamin D excess. Vitamin D 201-210 fibroblast growth factor 23 Homo sapiens 13-18 22396162-3 2012 In addition, FGF23 production is regulated by 1,25(OH)2D in a feedback loop where FGF23 stimulate Cyp24 mediated degradation of 1,25(OH)2D that serves to protect the organism from the toxic effects of vitamin D excess. Vitamin D 201-210 fibroblast growth factor 23 Homo sapiens 82-87 22396162-3 2012 In addition, FGF23 production is regulated by 1,25(OH)2D in a feedback loop where FGF23 stimulate Cyp24 mediated degradation of 1,25(OH)2D that serves to protect the organism from the toxic effects of vitamin D excess. Vitamin D 201-210 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 98-103 22396163-2 2012 Vitamin D can induce both FGF23 and klotho synthesis to influence renal phosphate balance. Vitamin D 0-9 fibroblast growth factor 23 Mus musculus 26-31 22396163-2 2012 Vitamin D can induce both FGF23 and klotho synthesis to influence renal phosphate balance. Vitamin D 0-9 klotho Mus musculus 36-42 22396163-6 2012 Vitamin D can induce the expression of both FGF23 and klotho while, FGF23 can suppress renal expression of 1alpha(OH)ase to reduce 1,25(OH)(2)D activity. Vitamin D 0-9 fibroblast growth factor 23 Mus musculus 44-49 22396163-6 2012 Vitamin D can induce the expression of both FGF23 and klotho while, FGF23 can suppress renal expression of 1alpha(OH)ase to reduce 1,25(OH)(2)D activity. Vitamin D 0-9 klotho Mus musculus 54-60 23183768-0 2012 Vitamin D analogs decrease in vitro secretion of RANTES and enhance the effect of budesonide. Vitamin D 0-9 C-C motif chemokine ligand 5 Homo sapiens 49-55 23183768-3 2012 The aim of this study was to assess the influence of vitamin D (VD) derivates on RANTES expression in the culture of nasal polyp fibroblasts. Vitamin D 53-62 C-C motif chemokine ligand 5 Homo sapiens 81-87 22213287-1 2012 BACKGROUND: Searching for additional therapeutic tools to fight breast cancer, we investigated the effects of vitamin D-binding protein-derived macrophage activating factor (DBP-MAF, also known as GcMAF) on a human breast cancer cell line (MCF-7). Vitamin D 110-119 GC vitamin D binding protein Homo sapiens 174-181 22213316-1 2012 The transcription factor vitamin D receptor (VDR) is the nuclear sensor for the biologically most active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)). Vitamin D 25-34 vitamin D receptor Homo sapiens 45-48 22213318-1 2012 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D [1alpha,25(OH)(2)D], interacts with vitamin D receptor (VDR) and induces antiproliferative, anti-invasive, proapoptotic and pro-differentiation activities in prostate cancer cells. Vitamin D 19-28 vitamin D receptor Homo sapiens 95-113 22213318-1 2012 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D [1alpha,25(OH)(2)D], interacts with vitamin D receptor (VDR) and induces antiproliferative, anti-invasive, proapoptotic and pro-differentiation activities in prostate cancer cells. Vitamin D 19-28 vitamin D receptor Homo sapiens 115-118 22213318-2 2012 Three cytochrome P-450 (CYP) hydroxylases are responsible for vitamin D synthesis and degradation, including vitamin D-25-hydroxylase (25-OHase) in the liver, and 25(OH)D-1alpha-hydroxylase (1alpha-OHase) or CYP27B1, and 25(OH)D-24-hydroxylase (24-OHase) or CYP24A1 in the kidneys. Vitamin D 62-71 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 245-253 22213318-2 2012 Three cytochrome P-450 (CYP) hydroxylases are responsible for vitamin D synthesis and degradation, including vitamin D-25-hydroxylase (25-OHase) in the liver, and 25(OH)D-1alpha-hydroxylase (1alpha-OHase) or CYP27B1, and 25(OH)D-24-hydroxylase (24-OHase) or CYP24A1 in the kidneys. Vitamin D 62-71 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 258-265 22213318-8 2012 Thus, in addition to 1alpha,25(OH)(2)D analogs, the presence of CYP2R1, CYP27B1 and CYP24A1 in the prostate suggests that the analogs of vitamin D and 25(OH)D, especially those that are resistant to CYP24A1 degradation, can be developed and used for the prevention and treatment of prostate cancer. Vitamin D 137-146 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 84-91 22213321-1 2012 The Delta(16) structure as a vitamin D analog enhanced vitamin D receptor (VDR) binding affinity and induced significant cell differentiation, whereas its relative calcemic activity was reduced compared to 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)). Vitamin D 29-38 vitamin D receptor Homo sapiens 55-73 22213321-1 2012 The Delta(16) structure as a vitamin D analog enhanced vitamin D receptor (VDR) binding affinity and induced significant cell differentiation, whereas its relative calcemic activity was reduced compared to 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)). Vitamin D 29-38 vitamin D receptor Homo sapiens 75-78 22213323-1 2012 BACKGROUND: Vitamin D receptor (VDR) polymorphisms have important implications for vitamin D signalling and are associated with various malignancies. Vitamin D 83-92 vitamin D receptor Homo sapiens 12-30 22213323-1 2012 BACKGROUND: Vitamin D receptor (VDR) polymorphisms have important implications for vitamin D signalling and are associated with various malignancies. Vitamin D 83-92 vitamin D receptor Homo sapiens 32-35 22213323-7 2012 Comparison of the frequencies of the VDR genotypes in sunlight-exposed vs. not sunlight-exposed skin areas revealed BB 30.1% vs. 7.1% respectively in BCCs and BB 28.1% vs. 0.0% respectively in SCCs, indicating that vitamin D signalling may be of importance for photocarcinogenesis of the skin. Vitamin D 215-224 vitamin D receptor Homo sapiens 37-40 22213325-3 2012 1,25-Dihydroxyvitamin D (1,25(OH)(2)D(3)) is the active form of vitamin D and exerts its actions via a specific intracellular vitamin D receptor (VDR). Vitamin D 14-23 vitamin D receptor Homo sapiens 126-144 22213325-3 2012 1,25-Dihydroxyvitamin D (1,25(OH)(2)D(3)) is the active form of vitamin D and exerts its actions via a specific intracellular vitamin D receptor (VDR). Vitamin D 14-23 vitamin D receptor Homo sapiens 146-149 22213328-3 2012 The antiproliferative effects of calcitriol [1,25(OH)(2)D(3)] mediated via the vitamin D receptor (VDR) render vitamin D a promising target in breast cancer therapy. Vitamin D 79-88 vitamin D receptor Homo sapiens 99-102 22300961-10 2012 Analysing combined effects, a significant impact of low 25-OH vitamin D levels on sustained virological response were only seen in patients with the unfavourable NR1I1 CCA (bAt) haplotype (OR for non-SVR 3.55; 95% CI 1.005, 12.57; P=0.049). Vitamin D 62-71 vitamin D receptor Homo sapiens 162-167 22312480-5 2012 It is also proposed that deprivation of sunlight and vitamin D at higher latitudes facilitates the development of autoimmune diseases by aggravating the CD8+ T-cell deficiency and thereby further impairing control of EBV. Vitamin D 53-62 CD8a molecule Homo sapiens 153-156 22466564-1 2012 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds to the vitamin D receptor (VDR) and regulates various physiological and pharmacological processes. Vitamin D 19-28 vitamin D receptor Homo sapiens 94-112 22466564-1 2012 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds to the vitamin D receptor (VDR) and regulates various physiological and pharmacological processes. Vitamin D 19-28 vitamin D receptor Homo sapiens 114-117 22246283-1 2012 BACKGROUND AND OBJECTIVES: Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism. Vitamin D 88-97 fibroblast growth factor 23 Homo sapiens 27-54 22246283-1 2012 BACKGROUND AND OBJECTIVES: Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism. Vitamin D 88-97 fibroblast growth factor 23 Homo sapiens 56-61 22738935-3 2012 Vitamin D has both stimulatory and protective effects on melanocytes and acts through its nuclear vitamin D receptor (VDR) on target cells. Vitamin D 0-9 vitamin D receptor Homo sapiens 98-116 22738935-3 2012 Vitamin D has both stimulatory and protective effects on melanocytes and acts through its nuclear vitamin D receptor (VDR) on target cells. Vitamin D 0-9 vitamin D receptor Homo sapiens 118-121 22785457-4 2012 In addition, genome-wide association studies and candidate gene studies have revealed that several vitamin D-related genes, including VDR, GC, NADSYN1, CYP2R1, CYP24A1, CYP27B1, and C10orf88 contribute to variations in serum 25(OH)D levels. Vitamin D 99-108 vitamin D receptor Homo sapiens 134-137 22785457-4 2012 In addition, genome-wide association studies and candidate gene studies have revealed that several vitamin D-related genes, including VDR, GC, NADSYN1, CYP2R1, CYP24A1, CYP27B1, and C10orf88 contribute to variations in serum 25(OH)D levels. Vitamin D 99-108 NAD synthetase 1 Homo sapiens 143-150 22785457-4 2012 In addition, genome-wide association studies and candidate gene studies have revealed that several vitamin D-related genes, including VDR, GC, NADSYN1, CYP2R1, CYP24A1, CYP27B1, and C10orf88 contribute to variations in serum 25(OH)D levels. Vitamin D 99-108 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 160-167 22785457-9 2012 Although this is a small study, our findings suggest that VDR, NADSYN1, and GC polymorphisms may be linked to the manifestation of vitamin D deficiency in Japanese children. Vitamin D 131-140 vitamin D receptor Homo sapiens 58-61 22785457-9 2012 Although this is a small study, our findings suggest that VDR, NADSYN1, and GC polymorphisms may be linked to the manifestation of vitamin D deficiency in Japanese children. Vitamin D 131-140 NAD synthetase 1 Homo sapiens 63-70 22606047-0 2012 Fibroblast growth factor-23 helps explain the biphasic cardiovascular effects of vitamin D in chronic kidney disease. Vitamin D 81-90 fibroblast growth factor 23 Homo sapiens 0-27 22606047-5 2012 Fibroblast growth factor-23 (FGF-23) is a recently identified member of the FGF family, and thought to be actively involved in renal phosphate and vitamin D homeostasis. Vitamin D 147-156 fibroblast growth factor 23 Homo sapiens 0-27 22606047-5 2012 Fibroblast growth factor-23 (FGF-23) is a recently identified member of the FGF family, and thought to be actively involved in renal phosphate and vitamin D homeostasis. Vitamin D 147-156 fibroblast growth factor 23 Homo sapiens 29-35 22606047-5 2012 Fibroblast growth factor-23 (FGF-23) is a recently identified member of the FGF family, and thought to be actively involved in renal phosphate and vitamin D homeostasis. Vitamin D 147-156 fibroblast growth factor 23 Homo sapiens 29-32 22606047-6 2012 More specifically, Vitamin D stimulates FGF-23 secretion and is inhibited by increased FGF-23. Vitamin D 19-28 fibroblast growth factor 23 Homo sapiens 40-46 22606047-6 2012 More specifically, Vitamin D stimulates FGF-23 secretion and is inhibited by increased FGF-23. Vitamin D 19-28 fibroblast growth factor 23 Homo sapiens 87-93 22606047-7 2012 Given this background, we hypothesize that FGF-23 may provide a unique tool to explain the biphasic cardiovascular effects of vitamin D in CKD. Vitamin D 126-135 fibroblast growth factor 23 Homo sapiens 43-49 22319626-0 2012 Klotho lacks a vitamin D independent physiological role in glucose homeostasis, bone turnover, and steady-state PTH secretion in vivo. Vitamin D 15-24 klotho Mus musculus 0-6 23166493-2 2012 We report here that TLR8 activation in human macrophages induces the expression of the human cathelicidin microbial peptide (CAMP), the vitamin D receptor (VDR) and cytochrome P450, family 27, subfamily B, polypeptide 1 (CYP27B1), which 1alpha-hydroxylates the inactive form of vitamin D, 25-hydroxycholecalciferol, into its biologically active metabolite. Vitamin D 136-145 vitamin D receptor Homo sapiens 156-159 23304521-2 2012 Vitamin D is considered to have anticancer properties, currently thought to work mainly through its nuclear receptor or vitamin D receptor. Vitamin D 0-9 vitamin D receptor Homo sapiens 120-138 22871095-2 2012 Pancreatic tissues express the vitamin D receptor (VDR) and vitamin D-binding protein; some allelic variations in genes involved in vitamin D metabolism and VDR are associated with glucose intolerance, defective insulin secretion, and sensitivity. Vitamin D 31-40 vitamin D receptor Homo sapiens 51-54 22871095-2 2012 Pancreatic tissues express the vitamin D receptor (VDR) and vitamin D-binding protein; some allelic variations in genes involved in vitamin D metabolism and VDR are associated with glucose intolerance, defective insulin secretion, and sensitivity. Vitamin D 31-40 vitamin D receptor Homo sapiens 157-160 22536762-5 2012 The hydrophobic nature of the analyte, the high concentration and affinity of vitamin D binding protein (VDBP) in serum and the cross-reactivity requirements due to the broad spectrum of metabolites of vitamin D are most demanding for assay development. Vitamin D 78-87 GC vitamin D binding protein Homo sapiens 105-109 22536764-3 2012 The active vitamin D metabolite, 1,25-dihydroxyvitamin D (1,25(OH)(2)D) binds to the vitamin D receptor (VDR) in the intestinal cell and stimulates the active calcium transport from the intestine to the circulation. Vitamin D 11-20 vitamin D receptor Homo sapiens 85-103 22536764-3 2012 The active vitamin D metabolite, 1,25-dihydroxyvitamin D (1,25(OH)(2)D) binds to the vitamin D receptor (VDR) in the intestinal cell and stimulates the active calcium transport from the intestine to the circulation. Vitamin D 11-20 vitamin D receptor Homo sapiens 105-108 22536764-7 2012 Both calcium and vitamin D metabolites can decrease the secretion of parathyroid hormone (PTH) through the calcium sensing receptor and the VDR respectively. Vitamin D 17-26 vitamin D receptor Homo sapiens 140-143 22536768-2 2012 Expression of the vitamin D receptor (VDR) and enzymes for vitamin D metabolism have been identified in the vasculature as well as in the heart. Vitamin D 18-27 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 38-41 22536770-2 2012 The vitamin D receptor (VDR) is highly expressed in epithelial cells at risk for carcinogenesis including those resident in skin, breast, prostate and colon, providing a direct molecular link by which vitamin D status impacts on carcinogenesis. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 22536770-7 2012 Because VDR expression is retained in many human tumors, vitamin D status may be an important modulator of cancer progression in persons living with cancer. Vitamin D 57-66 vitamin D receptor Homo sapiens 8-11 22066785-2 2011 This carborane-based VDR ligand exhibited moderate vitamin D activity, comparable to that of the natural hormone, despite its simple and flexible structure. Vitamin D 51-60 vitamin D receptor Homo sapiens 21-24 21930286-4 2011 We observed that adult offspring born to vitamin D deficient mothers, when compared to control offspring, developed a striking milder and delayed experimental autoimmune encephalomyelitis (EAE) and permanently overexpressed the vitamin D receptor. Vitamin D 41-50 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 228-246 22000399-4 2011 Recent technological advances have provided major insights as to how vitamin D may exert its role, particularly through the actions of the vitamin D receptor (VDR). Vitamin D 69-78 vitamin D receptor Homo sapiens 139-157 22000399-4 2011 Recent technological advances have provided major insights as to how vitamin D may exert its role, particularly through the actions of the vitamin D receptor (VDR). Vitamin D 69-78 vitamin D receptor Homo sapiens 159-162 21693169-1 2011 Hereditary Vitamin D Resistant Rickets (HVDRR) is a rare disease caused by mutations in the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 92-110 21693169-1 2011 Hereditary Vitamin D Resistant Rickets (HVDRR) is a rare disease caused by mutations in the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 41-44 21801808-5 2011 Conversely, any situation that impairs the efficiency of the 1,25-(OH)(2)D(3)/VDR signaling system at the level of the gut mucosa, e.g. vitamin D insufficiency, may increase risk for the development of IBD and colorectal cancer. Vitamin D 136-145 vitamin D receptor Homo sapiens 78-81 21914460-0 2011 Vitamin D metabolism in the kidney: regulation by phosphorus and fibroblast growth factor 23. Vitamin D 0-9 fibroblast growth factor 23 Homo sapiens 65-92 21914460-5 2011 Dietary Pi intake and serum Pi concentration also are important determinants of the circulating concentration of FGF-23, itself a potent regulator of Pi and vitamin D metabolism. Vitamin D 157-166 fibroblast growth factor 23 Homo sapiens 113-119 21334752-6 2011 We found negative correlations between Hsp70 levels and micronutrients including vitamin D, vitamin B12, as well as folate, which could be linked to the immune modulating effects of these vitamins. Vitamin D 81-90 heat shock protein family A (Hsp70) member 4 Homo sapiens 39-44 22218438-1 2011 The vitamin D endocrine system comprises a group of 7-dehydrocholesterol-derived secosteroid molecules, including its active metabolite 1,25-dihydroxy-vitamin D (1,25(OH)(2)D), its precursors and other metabolites, its binding protein (DBP) and nuclear receptor (VDR), as well as cytochrome P450 complex enzymes participating in activation and inactivation pathways of those molecules. Vitamin D 4-13 vitamin D receptor Homo sapiens 263-266 21550960-6 2011 RESULTS: Vitamin D therapy in the group with vitamin D deficiency led to a 26.7% decrease in BSAP (P<.01). Vitamin D 9-18 paired box 5 Homo sapiens 93-97 21550960-6 2011 RESULTS: Vitamin D therapy in the group with vitamin D deficiency led to a 26.7% decrease in BSAP (P<.01). Vitamin D 45-54 paired box 5 Homo sapiens 93-97 21550960-7 2011 Bisphosphonate therapy in the vitamin D-sufficient group led to a 32.7% decrease in BSAP (P = .01). Vitamin D 30-39 paired box 5 Homo sapiens 84-88 21550960-9 2011 CONCLUSION: The results of this study suggest that correction of vitamin D deficiency in patients with osteopenia and osteoporosis can lead to a decrease in bone turnover as measured by BSAP and that the magnitude of this reduction is similar to that achieved with orally administered bisphosphonates. Vitamin D 65-74 paired box 5 Homo sapiens 186-190 21803404-12 2011 CONCLUSION: Our results demonstrate how structural optimization of the vitamin-D scaffold leads to identification of a non-hypercalcemic compound MT19c which exerts cytotoxicity in vitro based on a VDR-independent signaling pathway and displays potent anti-cancer activity in ovarian cancer cell models. Vitamin D 71-80 vitamin D receptor Homo sapiens 198-201 21793032-5 2011 Treatment with vitamin D(3) resulted in calcitriol production and induction of calcitriol target gene CYP24A1, indicating that these cells contain the full machinery for vitamin D metabolism and activity. Vitamin D 15-24 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 102-109 21793032-5 2011 Treatment with vitamin D(3) resulted in calcitriol production and induction of calcitriol target gene CYP24A1, indicating that these cells contain the full machinery for vitamin D metabolism and activity. Vitamin D 170-179 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 102-109 21812032-0 2011 Hereditary vitamin D-resistant rickets (HVDRR) owing to a heterozygous mutation in the vitamin D receptor. Vitamin D 11-20 vitamin D receptor Homo sapiens 87-105 21812032-1 2011 Hereditary vitamin D-resistant rickets (HVDRR) is a rare autosomal recessive disease caused by mutations in the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 112-130 21812032-1 2011 Hereditary vitamin D-resistant rickets (HVDRR) is a rare autosomal recessive disease caused by mutations in the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 41-44 21769914-3 2011 We hypothesized that the breast adipocytes express the signaling components necessary to participate in vitamin D(3) synthesis and signaling via VDR, modulating ductal epithelial cell growth and differentiation. Vitamin D 104-113 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 145-148 21786227-6 2011 The association between altered levels of FGF23 and bone disease could be mainly due to the dysregulation of phosphate-handling and vitamin D metabolism, more than to a direct antiosteoblastic activity of FGF23. Vitamin D 132-141 fibroblast growth factor 23 Homo sapiens 42-47 21786227-10 2011 This paradox highlights the need for future prospective randomized trials to evaluate the correlation between vitamin D therapy and FGF23 levels in dialysis patients. Vitamin D 110-119 fibroblast growth factor 23 Homo sapiens 132-137 21684333-1 2011 Variants of the vitamin D binding protein (VDBP) gene appear to be associated with levels of the main circulating vitamin D metabolite, 25-hydroxyvitamin D [(25(OH)D]. Vitamin D 16-25 GC vitamin D binding protein Homo sapiens 43-47 21878656-4 2011 Here, we show that the application of the physiologically active form of vitamin D(3), calcitriol, inhibits proliferation and growth of BCC of Ptch mutant mice in vitro and in vivo. Vitamin D 73-82 patched 1 Mus musculus 143-147 21982773-4 2011 Herein we characterize vitamin D receptor-mediated regulation of klotho mRNA expression, including the identification of vitamin D responsive elements (VDREs) in the vicinity of both the mouse and human klotho genes. Vitamin D 23-32 klotho Mus musculus 65-71 21982773-4 2011 Herein we characterize vitamin D receptor-mediated regulation of klotho mRNA expression, including the identification of vitamin D responsive elements (VDREs) in the vicinity of both the mouse and human klotho genes. Vitamin D 23-32 klotho Homo sapiens 203-209 21982773-5 2011 In keeping with other recent studies of vitamin D-regulated genes, multiple VDREs control klotho expression, with the most active elements located at some distance (-31 to -46 kb) from the klotho transcriptional start site. Vitamin D 40-49 klotho Homo sapiens 90-96 21982773-5 2011 In keeping with other recent studies of vitamin D-regulated genes, multiple VDREs control klotho expression, with the most active elements located at some distance (-31 to -46 kb) from the klotho transcriptional start site. Vitamin D 40-49 klotho Homo sapiens 189-195 21947295-2 2011 Using Cre-Lox technology we have selectively deleted the vitamin D receptor (VDR) gene in the cardiac myocyte in an effort to better understand the role of vitamin D in regulating myocyte structure and function. Vitamin D 57-66 lysyl oxidase Homo sapiens 10-13 21947295-2 2011 Using Cre-Lox technology we have selectively deleted the vitamin D receptor (VDR) gene in the cardiac myocyte in an effort to better understand the role of vitamin D in regulating myocyte structure and function. Vitamin D 57-66 vitamin D receptor Homo sapiens 77-80 21868377-11 2011 We conclude that Dex increases VDR and vitamin D effects by increasing Vdr de novo transcription in a GR-dependent manner. Vitamin D 39-48 vitamin D receptor Homo sapiens 71-74 21853245-3 2011 RESULTS: Adjusted analyses showed that vitamin D levels were sub-optimal especially in the sun-sensitive individuals (-2.61 nmol/L, p = 0.03) and for inheritance of a genetic variant in the GC gene coding for the vitamin D-binding protein (-5.79 for heterozygotes versus wild type, p = <0.0001). Vitamin D 39-48 GC vitamin D binding protein Homo sapiens 213-238 21844098-2 2011 Here, we examined whether serum levels or genotypes of the vitamin D-binding protein (VDBP), a molecule key to the biologic actions of vitamin D, specifically associate with the disorder. Vitamin D 59-68 GC vitamin D binding protein Homo sapiens 86-90 22155603-9 2011 Based on the relationship between ultraviolet irradiance and vitamin D production, we employed a candidate gene approach for evaluating common variation in key vitamin D pathway genes (the genes encoding the vitamin D receptor [VDR]; cytochrome P450, family 27, subfamily B, polypeptide 1 [CYP27B1]; cytochrome P450, family 24, subfamily A, polypeptide 1 [CYP24A1]; and CYP27A1) in this same family-based cohort. Vitamin D 160-169 vitamin D receptor Homo sapiens 208-226 22155603-9 2011 Based on the relationship between ultraviolet irradiance and vitamin D production, we employed a candidate gene approach for evaluating common variation in key vitamin D pathway genes (the genes encoding the vitamin D receptor [VDR]; cytochrome P450, family 27, subfamily B, polypeptide 1 [CYP27B1]; cytochrome P450, family 24, subfamily A, polypeptide 1 [CYP24A1]; and CYP27A1) in this same family-based cohort. Vitamin D 160-169 vitamin D receptor Homo sapiens 228-231 22155603-11 2011 Single point variants in CYP24A1 (the gene encoding the catabolising enzyme of the vitamin D pathway) were demonstrated to influence AMD risk after controlling for smoking history, sex and age in all populations, both separately and, more importantly, in a meta-analysis. Vitamin D 83-92 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 25-32 21844150-2 2011 Vitamin D binding protein (DBP) is a highly polymorphic protein that transports vitamin D and its metabolites. Vitamin D 80-89 GC vitamin D binding protein Homo sapiens 0-25 21803771-8 2011 1,25(OH)(2)D(3) reversed high glucose-induced nephrin reduction in podocytes, and vitamin D analogs prevented nephrin decline in both type 1 and 2 diabetic mice. Vitamin D 82-91 nephrosis 1, nephrin Mus musculus 110-117 21803771-10 2011 Nephrin up-regulation likely accounts for part of the renoprotective activity of vitamin D. Vitamin D 81-90 nephrosis 1, nephrin Mus musculus 0-7 21529994-1 2011 The vitamin D metabolite, 1,25-(OH)2D3, binds the vitamin D receptor (VDR) to exert its regulatory effects at the transcription level. Vitamin D 4-13 vitamin D receptor Homo sapiens 50-68 21529994-1 2011 The vitamin D metabolite, 1,25-(OH)2D3, binds the vitamin D receptor (VDR) to exert its regulatory effects at the transcription level. Vitamin D 4-13 vitamin D receptor Homo sapiens 70-73 21496980-3 2011 FGF-23 is a bone-derived hormone that suppresses phosphate reabsorption and 1,25 dihydroxyvitamin D(3) (vitamin D) synthesis in the kidney. Vitamin D 90-99 fibroblast growth factor 23 Homo sapiens 0-6 21496980-4 2011 Klotho also is expressed in the parathyroid gland, where FGF-23 decreases parathyroid hormone expression and secretion, further suppressing vitamin D synthesis in kidney. Vitamin D 140-149 klotho Homo sapiens 0-6 21496980-4 2011 Klotho also is expressed in the parathyroid gland, where FGF-23 decreases parathyroid hormone expression and secretion, further suppressing vitamin D synthesis in kidney. Vitamin D 140-149 fibroblast growth factor 23 Homo sapiens 57-63 21496980-5 2011 Thus, FGF-23 functions as a phosphaturic hormone and a counter-regulatory hormone for vitamin D, thereby inducing negative phosphate balance. Vitamin D 86-95 fibroblast growth factor 23 Homo sapiens 6-12 21610497-2 2011 These changes are related and may be responsible for elevated 25-hydroxyvitamin D-24-hydroxylase (CYP24A1) and dysfunctional vitamin D metabolism. Vitamin D 72-81 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 98-105 21610497-7 2011 New data from the uremic rat and humans suggest that dysfunctional vitamin D metabolism is due to changes in CYP24A1 expression caused by phosphate and FGF-23 elevations. Vitamin D 67-76 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 109-116 21610497-7 2011 New data from the uremic rat and humans suggest that dysfunctional vitamin D metabolism is due to changes in CYP24A1 expression caused by phosphate and FGF-23 elevations. Vitamin D 67-76 fibroblast growth factor 23 Homo sapiens 152-158 21610497-8 2011 SUMMARY: Changes in serum phosphate and FGF-23 levels in the CKD patient increase CYP24A1 expression resulting in decreased vitamin D status. Vitamin D 124-133 fibroblast growth factor 23 Homo sapiens 40-46 21610497-8 2011 SUMMARY: Changes in serum phosphate and FGF-23 levels in the CKD patient increase CYP24A1 expression resulting in decreased vitamin D status. Vitamin D 124-133 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 82-89 21610497-10 2011 These findings argue for increased focus on correcting vitamin D deficiency in CKD patients by blocking CYP24A1 activity. Vitamin D 55-64 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 104-111 21654390-3 2011 RECENT FINDINGS: Findings from large-scale genome-wide association meta-analyses on 25(OH)D confirmed the associations for loci nearby genes encoding vitamin D binding protein (GC, group component), 7-dehydrochlesterol reductase (DHCR7), 25-hydroxylase (CYP2R1) and 24-hydroxylase (CYP24A1), all influencing key sites for vitamin D metabolism. Vitamin D 150-159 7-dehydrocholesterol reductase Homo sapiens 230-235 21654390-3 2011 RECENT FINDINGS: Findings from large-scale genome-wide association meta-analyses on 25(OH)D confirmed the associations for loci nearby genes encoding vitamin D binding protein (GC, group component), 7-dehydrochlesterol reductase (DHCR7), 25-hydroxylase (CYP2R1) and 24-hydroxylase (CYP24A1), all influencing key sites for vitamin D metabolism. Vitamin D 150-159 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 282-289 21537045-9 2011 CONCLUSION: High VDR expression in prostate tumors is associated with a reduced risk of lethal cancer, suggesting a role of the vitamin D pathway in prostate cancer progression. Vitamin D 128-137 vitamin D receptor Homo sapiens 17-20 21497493-1 2011 Since its first description as a phosphaturic agent in the early 2000s, fibroblast growth factor 23 (FGF23) has rapidly become the third key player of phosphate/calcium metabolism after PTH and vitamin D. Vitamin D 194-203 fibroblast growth factor 23 Homo sapiens 72-99 21497493-1 2011 Since its first description as a phosphaturic agent in the early 2000s, fibroblast growth factor 23 (FGF23) has rapidly become the third key player of phosphate/calcium metabolism after PTH and vitamin D. Vitamin D 194-203 fibroblast growth factor 23 Homo sapiens 101-106 21521263-2 2011 Vitamin D interacts with the vitamin D receptor (VDR) to negatively regulate renin expression in mice; however, human studies linking genetic variation in the VDR with renin are lacking. Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 29-47 21521263-2 2011 Vitamin D interacts with the vitamin D receptor (VDR) to negatively regulate renin expression in mice; however, human studies linking genetic variation in the VDR with renin are lacking. Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 49-52 21521263-2 2011 Vitamin D interacts with the vitamin D receptor (VDR) to negatively regulate renin expression in mice; however, human studies linking genetic variation in the VDR with renin are lacking. Vitamin D 0-9 vitamin D receptor Homo sapiens 159-162 21404002-1 2011 Fibroblast growth factor 23 (FGF23), a hormone primarily produced in bone cells, targets the kidney to accelerate phosphate excretion into the urine and suppresses vitamin D synthesis, thereby inducing a negative phosphate balance. Vitamin D 164-173 fibroblast growth factor 23 Homo sapiens 0-27 21404002-1 2011 Fibroblast growth factor 23 (FGF23), a hormone primarily produced in bone cells, targets the kidney to accelerate phosphate excretion into the urine and suppresses vitamin D synthesis, thereby inducing a negative phosphate balance. Vitamin D 164-173 fibroblast growth factor 23 Homo sapiens 29-34 21427118-1 2011 BACKGROUND: The vitamin D receptor (VDR) is expressed in human spermatozoa, and VDR-knockout mice and vitamin D (VD) deficiency in rodents results in impaired fertility, low sperm counts and a low number of motile spermatozoa. Vitamin D 16-25 vitamin D receptor Homo sapiens 36-39 20668935-2 2011 Effects of vitamin D are not only mediated via the vitamin D receptors by active vitamin D metabolites, but 25(OH)D(3) also acts through VDR-independent pathways directly. Vitamin D 11-20 vitamin D receptor Homo sapiens 137-140 21348760-8 2011 In this review, we will mainly focus on: (1) the application of genomic technologies for the identification and validation of molecular targets for chemoprevention; (2) the role of vitamin D and its cognate receptor VDR (vitamin D receptor) as a model for the molecularly targeted chemoprevention of breast cancer. Vitamin D 181-190 vitamin D receptor Homo sapiens 216-219 21348760-8 2011 In this review, we will mainly focus on: (1) the application of genomic technologies for the identification and validation of molecular targets for chemoprevention; (2) the role of vitamin D and its cognate receptor VDR (vitamin D receptor) as a model for the molecularly targeted chemoprevention of breast cancer. Vitamin D 181-190 vitamin D receptor Homo sapiens 221-239 21482732-1 2011 The vitamin D-activating enzyme 1alpha-hydroxylase (CYP27B1) and vitamin D receptor (VDR) support anti-inflammatory responses to vitamin D in many tissues. Vitamin D 4-13 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 85-88 21482732-2 2011 Given the high basal expression of CYP27B1 and VDR in trophoblastic cells from the placenta, we hypothesized that anti-inflammatory effects of vitamin D may be particularly important in this organ. Vitamin D 143-152 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 47-50 21378269-10 2011 CONCLUSIONS: These meta-analyses support the evidence of an inverse association between vitamin D intake, 25-hydroxyvitamin D status, and the BsmI VDR polymorphism and CRC risk. Vitamin D 88-97 vitamin D receptor Homo sapiens 147-150 21278761-2 2011 Vitamin D mediates its effect though binding to vitamin D receptor (VDR), and activation of VDR-responsive genes. Vitamin D 0-9 vitamin D receptor Homo sapiens 48-66 21278761-2 2011 Vitamin D mediates its effect though binding to vitamin D receptor (VDR), and activation of VDR-responsive genes. Vitamin D 0-9 vitamin D receptor Homo sapiens 68-71 21278761-2 2011 Vitamin D mediates its effect though binding to vitamin D receptor (VDR), and activation of VDR-responsive genes. Vitamin D 0-9 vitamin D receptor Homo sapiens 92-95 21441443-6 2011 We replicated the associations of four vitamin D metabolism genes (GC, DHCR7, CYP2R1, and CYP24A1) with 25(OH)D in control subjects. Vitamin D 39-48 7-dehydrocholesterol reductase Homo sapiens 71-76 21167925-0 2011 Vitamin D-deficient diet rescues hearing loss in Klotho mice. Vitamin D 0-9 klotho Mus musculus 49-55 21167925-4 2011 It was further demonstrated that a vitamin D-deficient diet normalizes serum calcitriol (1,25(OH)(2)D(3)) levels and prevents hearing loss in Klotho mice. Vitamin D 35-44 klotho Mus musculus 142-148 21337382-0 2011 Suppression of PTH by the vitamin D analog eldecalcitol is modulated by its high affinity for the serum vitamin D-binding protein and resistance to metabolism. Vitamin D 26-35 parathyroid hormone Bos taurus 15-18 21337382-0 2011 Suppression of PTH by the vitamin D analog eldecalcitol is modulated by its high affinity for the serum vitamin D-binding protein and resistance to metabolism. Vitamin D 26-35 GC vitamin D binding protein Bos taurus 104-129 21623580-1 2011 The widely differing functions of vitamin D are based both on a wide diffusion of its specific receptor (VDR) and on the ability of many cells, in addition to renal tubular cells, to synthesize calcitriol for autocrine and paracrine functions. Vitamin D 34-43 vitamin D receptor Homo sapiens 105-108 21623580-4 2011 Furthermore, the mechanisms by which the VDR might mediate either the genomic and nongenomic (rapid) vitamin D-mediated effects became much clearer. Vitamin D 101-110 vitamin D receptor Homo sapiens 41-44 21623580-5 2011 However, new evidence accumulated suggests that some additional receptor(s), responsive to vitamin D and different from the VDR, could play a role in the rapid response to vitamin D, probably interfering also with the genomic pathway. Vitamin D 172-181 vitamin D receptor Homo sapiens 124-127 20655720-2 2011 The study evaluates the effect of vitamin D(3) in preventing the altered function of cholinergic, insulin receptors and GLUT3 in the cerebral cortex of diabetic rats. Vitamin D 34-43 solute carrier family 2 member 3 Rattus norvegicus 120-125 21244571-1 2011 BACKGROUND AND OBJECTIVE: Vitamin D regulates the production of the antimicrobial peptides cathelicidin and beta-defensin-2, which play an important role in the innate immune response to infection. Vitamin D 26-35 defensin beta 4B Homo sapiens 108-123 21156217-5 2011 In laboratory parameters, vitamin D levels were inversely associated with serum IL-6 (p<0.001), IL-23 (p=0.011), IL-10 (p=0.033) cytokine levels, TM (p=0.001) and endothelin (p=0.033) levels. Vitamin D 26-35 interleukin 10 Homo sapiens 116-121 21169421-1 2011 Vitamin D compounds regulate PTH at the transcriptional level, presumably via binding to the vitamin D receptor (VDR), but the exact mechanism is presently unclear. Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 93-111 21169421-1 2011 Vitamin D compounds regulate PTH at the transcriptional level, presumably via binding to the vitamin D receptor (VDR), but the exact mechanism is presently unclear. Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 113-116 21169421-2 2011 We recently reported that the several vitamin D prohormones with low VDR affinity suppressed PTH, even when their activation was inhibited, raising the possibility that their actions may be VDR independent. Vitamin D 38-47 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 69-72 21169421-2 2011 We recently reported that the several vitamin D prohormones with low VDR affinity suppressed PTH, even when their activation was inhibited, raising the possibility that their actions may be VDR independent. Vitamin D 38-47 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 190-193 21169421-7 2011 These findings 1) are the first direct demonstration of the role of the VDR in regulation of PTH by 1alpha,25(OH)(2)D(3), 2) confirm that the suppressive actions of the vitamin D prohormones are mediated by the VDR, and 3) introduce a novel organ culture model that allows the ex vivo study of the function of parathyroid glands from transgenic animals. Vitamin D 169-178 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 72-75 21169421-7 2011 These findings 1) are the first direct demonstration of the role of the VDR in regulation of PTH by 1alpha,25(OH)(2)D(3), 2) confirm that the suppressive actions of the vitamin D prohormones are mediated by the VDR, and 3) introduce a novel organ culture model that allows the ex vivo study of the function of parathyroid glands from transgenic animals. Vitamin D 169-178 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 211-214 21383962-1 2011 BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a phosphaturic peptide and a key component of an endocrine feedback loop along with the hormonal vitamin D metabolite 1,25(OH)(2)D. Vitamin D has been shown to be inversely related to colorectal neoplasia; therefore, we hypothesized that the effect of FGF-23 on vitamin D metabolite concentrations could have implications for the risk of colorectal neoplasia. Vitamin D 149-158 fibroblast growth factor 23 Homo sapiens 12-39 21383962-1 2011 BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a phosphaturic peptide and a key component of an endocrine feedback loop along with the hormonal vitamin D metabolite 1,25(OH)(2)D. Vitamin D has been shown to be inversely related to colorectal neoplasia; therefore, we hypothesized that the effect of FGF-23 on vitamin D metabolite concentrations could have implications for the risk of colorectal neoplasia. Vitamin D 149-158 fibroblast growth factor 23 Homo sapiens 41-47 21383962-1 2011 BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a phosphaturic peptide and a key component of an endocrine feedback loop along with the hormonal vitamin D metabolite 1,25(OH)(2)D. Vitamin D has been shown to be inversely related to colorectal neoplasia; therefore, we hypothesized that the effect of FGF-23 on vitamin D metabolite concentrations could have implications for the risk of colorectal neoplasia. Vitamin D 184-193 fibroblast growth factor 23 Homo sapiens 12-39 21383962-1 2011 BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a phosphaturic peptide and a key component of an endocrine feedback loop along with the hormonal vitamin D metabolite 1,25(OH)(2)D. Vitamin D has been shown to be inversely related to colorectal neoplasia; therefore, we hypothesized that the effect of FGF-23 on vitamin D metabolite concentrations could have implications for the risk of colorectal neoplasia. Vitamin D 184-193 fibroblast growth factor 23 Homo sapiens 41-47 21383962-1 2011 BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a phosphaturic peptide and a key component of an endocrine feedback loop along with the hormonal vitamin D metabolite 1,25(OH)(2)D. Vitamin D has been shown to be inversely related to colorectal neoplasia; therefore, we hypothesized that the effect of FGF-23 on vitamin D metabolite concentrations could have implications for the risk of colorectal neoplasia. Vitamin D 314-323 fibroblast growth factor 23 Homo sapiens 12-39 21383962-1 2011 BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a phosphaturic peptide and a key component of an endocrine feedback loop along with the hormonal vitamin D metabolite 1,25(OH)(2)D. Vitamin D has been shown to be inversely related to colorectal neoplasia; therefore, we hypothesized that the effect of FGF-23 on vitamin D metabolite concentrations could have implications for the risk of colorectal neoplasia. Vitamin D 314-323 fibroblast growth factor 23 Homo sapiens 41-47 21143012-1 2011 BACKGROUND: Since the introduction of liquid chromatography-mass spectrometry (LC/MS) for assessing vitamin D status, it has been shown that the C-3 epimer can account for a significant proportion of circulating 25-hydroxyvitamin D3 (25OHD3) concentrations in infants. Vitamin D 100-109 complement C3 Homo sapiens 145-148 21292848-11 2011 Vitamin D sterols can improve vitamin D deficiency and PTH levels but may worsen phosphate retention and increase FGF-23 levels, and thus, may also require concomitant phosphate binder therapy. Vitamin D 0-9 fibroblast growth factor 23 Homo sapiens 114-120 21164021-4 2011 Independent of changes in intestinal calcium absorption and serum calcium, 1alpha,25-dihydroxyvitamin D also represses the transcription of PTH by associating with the vitamin D receptor, which heterodimerizes with retinoic acid X receptors to bind vitamin D-response elements within the PTH gene. Vitamin D 94-103 vitamin D receptor Homo sapiens 168-186 21625107-5 2011 In the chronic kidney disease (CKD) population, vitamin D receptor (VDR) activation deficiency is even more severe than in a non-CKD population, with a 25-(OH) vitamin D level being an independent predictor of all-cause mortality. Vitamin D 48-57 vitamin D receptor Homo sapiens 68-71 21269569-1 2011 Most of the biological actions of vitamin D are mediated by an intracellular receptor (VDR) in which several single nucleotide gene polymorphisms have been identified. Vitamin D 34-43 vitamin D receptor Homo sapiens 87-90 21897759-2 2011 The discovery of Fibroblast Growth Factor 23 (FGF23) has revolutionized our understanding about the links between mineral metabolism, vitamin D and parathyroid hormone (PTH). Vitamin D 134-143 fibroblast growth factor 23 Homo sapiens 17-44 21897759-2 2011 The discovery of Fibroblast Growth Factor 23 (FGF23) has revolutionized our understanding about the links between mineral metabolism, vitamin D and parathyroid hormone (PTH). Vitamin D 134-143 fibroblast growth factor 23 Homo sapiens 46-51 21542721-8 2011 Also, the levels of transforming growth factor-beta and interleukin-10 in the vitamin D treatment group were significantly higher than the control group. Vitamin D 78-87 interleukin 10 Homo sapiens 56-70 20943786-7 2011 Vitamin D deficiency or insufficiency was slightly more prevalent in diabetic subjects with albuminuria, coincident with the increase in urine VDBP excretion. Vitamin D 0-9 GC vitamin D binding protein Homo sapiens 143-147 20943786-8 2011 CONCLUSIONS: These findings suggest that, theoretically, exaggerated urinary loss of VDBP in T1D, particularly in persons with albuminuria, could contribute mechanistically to vitamin D deficiency in this disease. Vitamin D 176-185 GC vitamin D binding protein Homo sapiens 85-89 22145479-0 2011 Report of two unrelated patients with hereditary vitamin D resistant rickets due to the same novel mutation in the vitamin D receptor. Vitamin D 49-58 vitamin D receptor Homo sapiens 115-133 22145480-3 2011 Vitamin D dependent rickets type 2 (VDDR-II) is caused by a defect in the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 74-92 22145480-3 2011 Vitamin D dependent rickets type 2 (VDDR-II) is caused by a defect in the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 94-97 20714323-0 2011 Vitamin D inhibits CEACAM1 to promote insulin/IGF-I receptor signaling without compromising anti-proliferative action. Vitamin D 0-9 CEA cell adhesion molecule 1 Homo sapiens 19-26 20714323-0 2011 Vitamin D inhibits CEACAM1 to promote insulin/IGF-I receptor signaling without compromising anti-proliferative action. Vitamin D 0-9 insulin like growth factor 1 receptor Homo sapiens 46-60 21829599-6 2011 We confirmed the binding of the VDR phage to active Vitamin D in vitro, as well as the higher expression of VDR in CD4+CD25+ cells. Vitamin D 52-61 vitamin D receptor Homo sapiens 32-35 21351666-3 2011 The best known genes related to bone density have been identified as the genes for the vitamin D, estrogen and calcitonin receptor, LRP5 and LRP6. Vitamin D 87-96 LDL receptor related protein 6 Homo sapiens 141-145 21234310-4 2010 Both Klotho and FGF-23, linked by a receptor mechanism, affect vitamin D synthesis and parathyroid hormone (PTH) secretion. Vitamin D 63-72 klotho Homo sapiens 5-11 21234310-4 2010 Both Klotho and FGF-23, linked by a receptor mechanism, affect vitamin D synthesis and parathyroid hormone (PTH) secretion. Vitamin D 63-72 fibroblast growth factor 23 Homo sapiens 16-22 21058632-3 2010 A convenient and reliable cell-free assay was established and used to screen vitamin D analogues with potential inhibitory properties toward CYP24A1. Vitamin D 77-86 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 141-148 20974859-8 2010 Our results suggest a novel, post-transcriptional mechanism whereby Th17 cytokines are inhibited by VDR, which may underscore future therapeutic usage of vitamin D in treatment of autoimmune diseases. Vitamin D 154-163 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 100-103 20707671-1 2010 UNLABELLED: Abstract Background: Fibroblast growth factor 23 (FGF-23), a phosphaturic peptide hormone secreted by the osteoblasts, is an important regulator of phosphorus and vitamin D metabolism. Vitamin D 175-184 fibroblast growth factor 23 Homo sapiens 33-60 20707671-1 2010 UNLABELLED: Abstract Background: Fibroblast growth factor 23 (FGF-23), a phosphaturic peptide hormone secreted by the osteoblasts, is an important regulator of phosphorus and vitamin D metabolism. Vitamin D 175-184 fibroblast growth factor 23 Homo sapiens 62-68 21113195-1 2010 Vitamin D is a seco-steroid involved in calcium and phosphorus metabolism, and bone formation and mineralization, through binding to a specific nuclear receptor, vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 162-180 21113195-1 2010 Vitamin D is a seco-steroid involved in calcium and phosphorus metabolism, and bone formation and mineralization, through binding to a specific nuclear receptor, vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 182-185 20719979-3 2010 Klotho hypomorphic mice (klotho(hm)) suffer from severe growth deficit, rapid aging, and early death, events largely reversed by a vitamin D-deficient diet. Vitamin D 131-140 klotho Mus musculus 0-6 20719979-3 2010 Klotho hypomorphic mice (klotho(hm)) suffer from severe growth deficit, rapid aging, and early death, events largely reversed by a vitamin D-deficient diet. Vitamin D 131-140 klotho Mus musculus 25-31 20732956-0 2010 Effects of vitamin D replacement therapy on serum FGF23 concentrations in vitamin D-deficient women in short term. Vitamin D 11-20 fibroblast growth factor 23 Homo sapiens 50-55 20732956-0 2010 Effects of vitamin D replacement therapy on serum FGF23 concentrations in vitamin D-deficient women in short term. Vitamin D 74-83 fibroblast growth factor 23 Homo sapiens 50-55 20732956-7 2010 RESULTS: Serum FGF23 concentrations were significantly lower in vitamin D-deficient patients than in vitamin D-sufficient women and hypophosphatemic rachitis group. Vitamin D 64-73 fibroblast growth factor 23 Homo sapiens 15-20 20732956-7 2010 RESULTS: Serum FGF23 concentrations were significantly lower in vitamin D-deficient patients than in vitamin D-sufficient women and hypophosphatemic rachitis group. Vitamin D 101-110 fibroblast growth factor 23 Homo sapiens 15-20 20732956-8 2010 Serum FGF23 and phosphate concentrations further decreased significantly during replacement of vitamin D (P<0.05). Vitamin D 95-104 fibroblast growth factor 23 Homo sapiens 6-11 20732956-9 2010 A significant negative correlation was evident between FGF23 and PTH before vitamin D replacement in the patients (r=-0.469, P<0.05). Vitamin D 76-85 fibroblast growth factor 23 Homo sapiens 55-60 20732956-10 2010 CONCLUSION: Decreased FGF23 concentrations, which further decline during vitamin D replacement therapy, may have favorable action on bone mineralization by counterregulatory effect on phosphate homeostasis. Vitamin D 73-82 fibroblast growth factor 23 Homo sapiens 22-27 20732956-11 2010 Lower 1,25(OH)2D concentrations at baseline and hypophosphatemia during treatment may have dominating effects on FGF23 concentrations in vitamin D deficiency, leading to decreased FGF23 concentrations at baseline and during replacement therapy. Vitamin D 137-146 fibroblast growth factor 23 Homo sapiens 113-118 20684976-11 2010 Deficiency in vitamin D may provide an etiologic link between the long-known ecologic findings regarding latitude and the basic science noting polymorphisms in the vitamin D receptor. Vitamin D 14-23 vitamin D receptor Homo sapiens 164-182 20667908-3 2010 In addition, over the past decade there has been a dramatic increase in our understanding of the many biological actions that result from vitamin D acting through its daughter steroid hormone, 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] in collaboration with its cognate vitamin D receptor (VDR). Vitamin D 138-147 vitamin D receptor Homo sapiens 282-300 20667908-3 2010 In addition, over the past decade there has been a dramatic increase in our understanding of the many biological actions that result from vitamin D acting through its daughter steroid hormone, 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] in collaboration with its cognate vitamin D receptor (VDR). Vitamin D 138-147 vitamin D receptor Homo sapiens 302-305 20711952-8 2010 Vitamin D stimulates ovarian steroidogenesis and IGFBP-1 production in human ovarian cells likely acting via vitamin D receptor. Vitamin D 0-9 vitamin D receptor Homo sapiens 109-127 20407924-5 2010 Vitamin-D acts through vitamin-D-receptor (VDR), which regulates the expression of vitamin-D-response genes. Vitamin D 0-9 vitamin D receptor Homo sapiens 23-41 20407924-5 2010 Vitamin-D acts through vitamin-D-receptor (VDR), which regulates the expression of vitamin-D-response genes. Vitamin D 0-9 vitamin D receptor Homo sapiens 43-46 20407924-5 2010 Vitamin-D acts through vitamin-D-receptor (VDR), which regulates the expression of vitamin-D-response genes. Vitamin D 23-32 vitamin D receptor Homo sapiens 43-46 20488884-1 2010 A central paradox of vitamin D biology is that 1alpha,25-(OH)(2) D(3) exposure inversely relates to colorectal cancer (CRC) risk despite a capacity for activation of both pro- and anti-oncogenic mediators including osteopontin (OPN)/CD44 and E-cadherin, respectively. Vitamin D 21-30 CD44 molecule (Indian blood group) Homo sapiens 233-237 20675935-3 2010 Loss-of-function mutation of 1alpha-hydroxylase gene and loss-of-function mutation of VDR gene result in vitamin D-dependent rickets type I and type II, respectively. Vitamin D 105-114 vitamin D receptor Homo sapiens 86-89 20399147-6 2010 Our results suggest that the down-regulation of ICAM-1 and LFA-1 on PBMC and the inhibition of MMP-9 activity by ZK could provide a potential role of this low calcemic vitamin D derivative in future strategies in IBD therapy. Vitamin D 168-177 matrix metallopeptidase 9 Homo sapiens 95-100 20585181-5 2010 In patients undergoing dialysis, FGF23 levels are markedly elevated in response to hyperphosphatemia and active vitamin D therapy, which in turn cause hypophosphatemia and reduced 1,25-dihydroxyvitamin D after kidney transplantation. Vitamin D 112-121 fibroblast growth factor 23 Homo sapiens 33-38 20868571-15 2010 Our results showed that low levels of vitamin D were associated with a decrease in Treg cells and a skewing of the Th1/Th2 balance towards Th1. Vitamin D 38-47 negative elongation factor complex member C/D Homo sapiens 115-118 20868571-15 2010 Our results showed that low levels of vitamin D were associated with a decrease in Treg cells and a skewing of the Th1/Th2 balance towards Th1. Vitamin D 38-47 negative elongation factor complex member C/D Homo sapiens 139-142 20583336-4 2010 Finally, new data demonstrate the ability to alter FGF23 levels using common CKD therapies such as phosphate binders, active vitamin D, and cinacalcet. Vitamin D 125-134 fibroblast growth factor 23 Homo sapiens 51-56 20463051-8 2010 Thus, prolactin, by multiple mechanisms, including regulation of vitamin D metabolism, induction of TRPV6 mRNA, and cooperation with 1,25(OH)(2)D(3) in induction of intestinal calcium transport genes and intestinal calcium transport, can act as an important modulator of vitamin D-regulated calcium homeostasis. Vitamin D 65-74 prolactin Mus musculus 6-15 20463051-8 2010 Thus, prolactin, by multiple mechanisms, including regulation of vitamin D metabolism, induction of TRPV6 mRNA, and cooperation with 1,25(OH)(2)D(3) in induction of intestinal calcium transport genes and intestinal calcium transport, can act as an important modulator of vitamin D-regulated calcium homeostasis. Vitamin D 271-280 prolactin Mus musculus 6-15 20459364-4 2010 The FGF23-klotho system not only affects phosphate homeostasis but can also influence parathyroid hormone (PTH) and vitamin D activities. Vitamin D 116-125 fibroblast growth factor 23 Mus musculus 4-9 20459364-4 2010 The FGF23-klotho system not only affects phosphate homeostasis but can also influence parathyroid hormone (PTH) and vitamin D activities. Vitamin D 116-125 klotho Mus musculus 10-16 20459364-6 2010 Vitamin D is a strong inducer of both FGF23 and klotho expression, while FGF23 can suppress the renal expression of 1alpha(OH)ase to reduce 1,25(OH)(2)D activity. Vitamin D 0-9 fibroblast growth factor 23 Mus musculus 38-43 20459364-6 2010 Vitamin D is a strong inducer of both FGF23 and klotho expression, while FGF23 can suppress the renal expression of 1alpha(OH)ase to reduce 1,25(OH)(2)D activity. Vitamin D 0-9 klotho Mus musculus 48-54 20459364-7 2010 An understanding of the complex interactions of phosphate, vitamin D and PTH with the FGF23-klotho system has paved the way to explore the therapeutic benefits of modulating the FGF23-klotho system in diseases associated with abnormal mineral ion balance. Vitamin D 59-68 fibroblast growth factor 23 Mus musculus 86-91 20459364-7 2010 An understanding of the complex interactions of phosphate, vitamin D and PTH with the FGF23-klotho system has paved the way to explore the therapeutic benefits of modulating the FGF23-klotho system in diseases associated with abnormal mineral ion balance. Vitamin D 59-68 klotho Mus musculus 92-98 20427486-2 2010 Both vitamin D metabolites circulate bound to vitamin D-binding protein (DBP), but the effect of this on induction of monocyte cathelicidin remains unclear. Vitamin D 5-14 GC vitamin D binding protein Homo sapiens 46-71 20138989-1 2010 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25D), has a broad range of effects which are mediated by nuclear vitamin D receptor (VDR). Vitamin D 19-28 vitamin D receptor Homo sapiens 128-146 20138989-1 2010 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25D), has a broad range of effects which are mediated by nuclear vitamin D receptor (VDR). Vitamin D 19-28 vitamin D receptor Homo sapiens 148-151 20138990-1 2010 Vitamin D receptor (VDR) mediates the antitumoral action of the active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3). Vitamin D 71-80 vitamin D receptor Homo sapiens 0-18 20138990-1 2010 Vitamin D receptor (VDR) mediates the antitumoral action of the active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3). Vitamin D 71-80 vitamin D receptor Homo sapiens 20-23 20138990-9 2010 In addition, they may contribute to the improvement of protocols for the clinical use of vitamin D compounds, as they indicate that advanced colon cancer patients overexpressing SNAIL1 and SNAIL2 are not suitable candidates for this therapy. Vitamin D 89-98 snail family transcriptional repressor 2 Homo sapiens 189-195 20144713-0 2010 CYP24A1-deficient mice as a tool to uncover a biological activity for vitamin D metabolites hydroxylated at position 24. Vitamin D 70-79 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 0-7 20144713-8 2010 These results show that Cyp24a1 deficiency delays fracture repair and strongly suggest that vitamin D metabolites hydroxylated at position 24, such as 24,25(OH)2D3, play an important role in the mechanisms leading to normal fracture healing. Vitamin D 92-101 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 24-31 20171278-0 2010 Genome-wide analysis of the VDR/RXR cistrome in osteoblast cells provides new mechanistic insight into the actions of the vitamin D hormone. Vitamin D 122-131 vitamin D receptor Homo sapiens 28-31 20171278-0 2010 Genome-wide analysis of the VDR/RXR cistrome in osteoblast cells provides new mechanistic insight into the actions of the vitamin D hormone. Vitamin D 122-131 retinoid X receptor alpha Homo sapiens 32-35 20171278-1 2010 The vitamin D receptor (VDR) mediates the actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in target cells and tissues by orchestrating the expression of gene networks responsible for vitamin D-induced phenotypes. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 20227497-3 2010 Vitamin D also elicits numerous intracrine actions when circulating 25-hydroxyvitamin D3, the metabolite reflecting vitamin D status, is converted to 1,25D locally by extrarenal CYP27B1, and binds VDR to promote immunoregulation, antimicrobial defense, xenobiotic detoxification, anti-inflammatory/anticancer actions and cardiovascular benefits. Vitamin D 0-9 vitamin D receptor Homo sapiens 197-200 20227497-3 2010 Vitamin D also elicits numerous intracrine actions when circulating 25-hydroxyvitamin D3, the metabolite reflecting vitamin D status, is converted to 1,25D locally by extrarenal CYP27B1, and binds VDR to promote immunoregulation, antimicrobial defense, xenobiotic detoxification, anti-inflammatory/anticancer actions and cardiovascular benefits. Vitamin D 78-87 vitamin D receptor Homo sapiens 197-200 20304059-2 2010 We developed a system for isolation of fresh endothelial cells from tumors and Matrigel environments which demonstrate that CYP24, the catabolic enzyme involved in vitamin D signaling, is epigenetically silenced selectively in tumor-derived endothelial cells (TDEC). Vitamin D 164-173 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 124-129 20304061-2 2010 Vitamin D is thought to have both direct (through activation of the vitamin D receptor) and indirect (via regulation of calcium homeostasis) effects on various mechanisms related to the pathophysiology of both types of diabetes, including pancreatic beta-cell dysfunction, impaired insulin action and systemic inflammation. Vitamin D 0-9 vitamin D receptor Homo sapiens 68-86 20307661-0 2010 Association between polymorphic variation in VDR and RXRA and circulating levels of vitamin D metabolites. Vitamin D 84-93 vitamin D receptor Homo sapiens 45-48 20307661-0 2010 Association between polymorphic variation in VDR and RXRA and circulating levels of vitamin D metabolites. Vitamin D 84-93 retinoid X receptor alpha Homo sapiens 53-57 20307661-1 2010 The vitamin D metabolite 1,25(OH)2D is the bioactive ligand of the vitamin D receptor (VDR). Vitamin D 4-13 vitamin D receptor Homo sapiens 67-85 20307661-1 2010 The vitamin D metabolite 1,25(OH)2D is the bioactive ligand of the vitamin D receptor (VDR). Vitamin D 4-13 vitamin D receptor Homo sapiens 87-90 20307661-2 2010 VDR forms a heterodimer with the retinoid X receptors (RXRs) that when bound to ligand influences the transcriptional control of genes that regulate circulating levels of vitamin D metabolites. Vitamin D 171-180 vitamin D receptor Homo sapiens 0-3 20359533-0 2010 Vitamin D inhibition of TACE and prevention of renal osteodystrophy and cardiovascular mortality. Vitamin D 0-9 ADAM metallopeptidase domain 17 Homo sapiens 24-28 20398751-2 2010 The unbalanced high levels of CYP24A1 seem to be a determinant of vitamin D resistance in tumors. Vitamin D 66-75 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 30-37 20403435-1 2010 In the nuclear receptor of vitamin D (VDR) histidine 305 participates to the anchoring of the ligand. Vitamin D 27-36 vitamin D receptor Homo sapiens 38-41 20403435-2 2010 The VDR H305Q mutation was identified in a patient who exhibited the hereditary vitamin D-resistant rickets (HVDRR). Vitamin D 80-89 vitamin D receptor Homo sapiens 4-7 20236932-1 2010 CYP24A1 expression is up-regulated by 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) via a vitamin D receptor (VDR)/retinoid X receptor (RXR) heterodimer that binds to two vitamin D response elements (VDREs) located near the proximal promoter. Vitamin D 52-61 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 0-7 20236932-1 2010 CYP24A1 expression is up-regulated by 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) via a vitamin D receptor (VDR)/retinoid X receptor (RXR) heterodimer that binds to two vitamin D response elements (VDREs) located near the proximal promoter. Vitamin D 52-61 vitamin D receptor Homo sapiens 89-107 20236932-1 2010 CYP24A1 expression is up-regulated by 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) via a vitamin D receptor (VDR)/retinoid X receptor (RXR) heterodimer that binds to two vitamin D response elements (VDREs) located near the proximal promoter. Vitamin D 52-61 vitamin D receptor Homo sapiens 109-112 20236932-1 2010 CYP24A1 expression is up-regulated by 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) via a vitamin D receptor (VDR)/retinoid X receptor (RXR) heterodimer that binds to two vitamin D response elements (VDREs) located near the proximal promoter. Vitamin D 52-61 retinoid X receptor alpha Homo sapiens 114-133 20236932-1 2010 CYP24A1 expression is up-regulated by 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) via a vitamin D receptor (VDR)/retinoid X receptor (RXR) heterodimer that binds to two vitamin D response elements (VDREs) located near the proximal promoter. Vitamin D 52-61 retinoid X receptor alpha Homo sapiens 135-138 20236932-8 2010 We conclude that a more complex mechanism is responsible for the striking CYP24A1 up-regulation induced by the vitamin D hormone in target cells. Vitamin D 111-120 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 74-81 20592360-2 2010 The antiproliferative effects of calcitriol (1,25(OH)(2)D(3)) mediated via the vitamin D receptor (VDR) render vitamin D a promising target in breast cancer therapy. Vitamin D 79-88 vitamin D receptor Homo sapiens 99-102 20090765-5 2010 However, 1,25(OH)(2) vitamin D(3), 9-cis retinoic acid (RA), and 13-cis RA also induced the KLKs, but the timing and pattern of KLK induction for each were different and distinct from changes in differentiation markers. Vitamin D 21-30 kallikrein related peptidase 4 Homo sapiens 92-96 20303786-2 2010 The CaR regulates the release of parathyroid hormone (PTH) in response to changes in extracellular calcium, whereas the VDR mediates the effects of calcitriol, the active metabolite of vitamin D. Vitamin D 185-194 vitamin D receptor Homo sapiens 120-123 20435872-7 2010 The majority of circulating vitamin D is bound to VDBP, and its uptake into cells occurs in both bound and unbound forms, which suggests the role of VDBP warrants further study in these conditions as well. Vitamin D 28-37 GC vitamin D binding protein Homo sapiens 50-54 20435872-7 2010 The majority of circulating vitamin D is bound to VDBP, and its uptake into cells occurs in both bound and unbound forms, which suggests the role of VDBP warrants further study in these conditions as well. Vitamin D 28-37 GC vitamin D binding protein Homo sapiens 149-153 20398021-1 2010 The bioactive form of vitamin D, 1,25-dihydroxyvitamin D(3), is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the nuclear receptor superfamily, and modulates a variety of biological functions. Vitamin D 22-31 vitamin D receptor Homo sapiens 104-122 20398021-1 2010 The bioactive form of vitamin D, 1,25-dihydroxyvitamin D(3), is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the nuclear receptor superfamily, and modulates a variety of biological functions. Vitamin D 22-31 vitamin D receptor Homo sapiens 124-127 20960270-6 2010 Unexpectedly, alendronate at 10-7 and 10-5 M concentrations increased the RANKL expression with the presence of vitamin D in differentiated hOB, and this induction of RANKL mRNA levels by alendronate was dose-dependent. Vitamin D 112-121 TNF superfamily member 11 Homo sapiens 74-79 20960270-8 2010 Thus, we conclude that alendronate does not affect the ALP activity and OPG gene expression in differentiated hOB, but may increase RANKL gene expression induced by vitamin D. Vitamin D 165-174 TNF superfamily member 11 Homo sapiens 132-137 20197072-3 2010 FGF23 also reduces serum vitamin D levels to suppress phosphate absorption from intestine. Vitamin D 25-34 fibroblast growth factor 23 Mus musculus 0-5 20043299-1 2010 The activity of beta-catenin, commonly dysregulated in human colon cancers, is inhibited by the vitamin D receptor (VDR), and this mechanism is postulated to explain the putative anti-cancer activity of vitamin D metabolites in the colon. Vitamin D 96-105 vitamin D receptor Homo sapiens 116-119 20177401-4 2010 Recent findings also indicate that fibroblast growth factor 23 has feedback mechanisms involving parathyroid hormone and vitamin D that control phosphate homeostasis. Vitamin D 121-130 fibroblast growth factor 23 Homo sapiens 35-62 19626341-2 2010 When phosphate is in excess, fibroblast growth factor-23 (FGF23) is secreted from bone and acts on the kidney to promote phosphate excretion into urine and suppress vitamin D synthesis, thereby inducing negative phosphate balance. Vitamin D 165-174 fibroblast growth factor 23 Homo sapiens 29-56 19626341-2 2010 When phosphate is in excess, fibroblast growth factor-23 (FGF23) is secreted from bone and acts on the kidney to promote phosphate excretion into urine and suppress vitamin D synthesis, thereby inducing negative phosphate balance. Vitamin D 165-174 fibroblast growth factor 23 Homo sapiens 58-63 20012997-1 2010 Recent studies have demonstrated that levels of fibroblast growth factor 23 (FGF-23), a key regulator of phosphorus and vitamin D metabolism, rise dramatically as renal function declines and may play a key initiating role in disordered mineral and bone metabolism in patients with chronic kidney disease (CKD). Vitamin D 120-129 fibroblast growth factor 23 Homo sapiens 48-75 20012997-1 2010 Recent studies have demonstrated that levels of fibroblast growth factor 23 (FGF-23), a key regulator of phosphorus and vitamin D metabolism, rise dramatically as renal function declines and may play a key initiating role in disordered mineral and bone metabolism in patients with chronic kidney disease (CKD). Vitamin D 120-129 fibroblast growth factor 23 Homo sapiens 77-83 20144976-1 2010 BACKGROUND: Vitamin D binding protein (DBP) acts as a vitamin D carrier and an actin scavenger. Vitamin D 54-63 GC vitamin D binding protein Homo sapiens 12-37 20133492-5 2010 VDR agonists effectively treat SHPT and vitamin D deficiency, but dosing needs to be optimized for each patient because the patient responds in an individualized manner to treatment to suppress and stabilize PTH levels. Vitamin D 40-49 vitamin D receptor Homo sapiens 0-3 20363711-8 2010 Vitamin D deficiency is widespread in the older adult population as a result of low dietary intake, decreased sun exposure, decreased intrinsic vitamin D production, and decreased vitamin D receptor activity. Vitamin D 0-9 vitamin D receptor Homo sapiens 180-198 20020446-0 2010 Upregulation of MMP-9 production by TNFalpha in keratinocytes and its attenuation by vitamin D. Vitamin D 85-94 matrix metallopeptidase 9 Homo sapiens 16-21 20020446-12 2010 By down-regulating MMP-9 levels active vitamin D derivatives may attenuate deleterious effects due to excessive TNFalpha-induced proteolytic activity associated with cutaneous inflammation. Vitamin D 39-48 matrix metallopeptidase 9 Homo sapiens 19-24 20172224-10 2010 Vitamin D status of cattle might be important for optimal innate immune function because 1,25(OH)(2)D(3) production in activated monocytes and subsequent upregulation of inducible nitric oxide synthase and RANTES expression was dependent on 25(OH)D(3) availability. Vitamin D 0-9 nitric oxide synthase 2 Bos taurus 170-201 20059333-2 2010 Fibroblast growth factor 23 (FGF23) is part of a previously unrecognized hormonal bone-parathyroid-kidney axis, which is modulated by PTH, 1,25(OH)(2)-vitamin D (1,25(OH)(2)D), dietary and serum phosphorus levels. Vitamin D 151-160 fibroblast growth factor 23 Homo sapiens 0-27 20059333-2 2010 Fibroblast growth factor 23 (FGF23) is part of a previously unrecognized hormonal bone-parathyroid-kidney axis, which is modulated by PTH, 1,25(OH)(2)-vitamin D (1,25(OH)(2)D), dietary and serum phosphorus levels. Vitamin D 151-160 fibroblast growth factor 23 Homo sapiens 29-34 21139376-3 2010 Liganded VDR heterodimerizes with the retinoid X receptor and interacts with a vitamin D response element (VDRE). Vitamin D 79-88 vitamin D receptor Homo sapiens 9-12 21139376-3 2010 Liganded VDR heterodimerizes with the retinoid X receptor and interacts with a vitamin D response element (VDRE). Vitamin D 79-88 retinoid X receptor alpha Homo sapiens 38-57 20055894-7 2010 Vitamin D stimulated CYP24A, BGLAP and TNFSF11 expression in hOB and these effects were modified by nontoxic LCA concentrations. Vitamin D 0-9 TNF superfamily member 11 Homo sapiens 39-46 20055894-8 2010 LCA significantly decreased vitamin D stimulation of CYP24A, BGLAP and TNFSF11 gene expression at 72%, 79% and 56% (respectively). Vitamin D 28-37 TNF superfamily member 11 Homo sapiens 71-78 20055894-11 2010 CONCLUSIONS: Lithocholic acid decreases the stimulatory effect of vitamin D on CYP24A, BGLAP and TNFSF11 expression in hOB. Vitamin D 66-75 TNF superfamily member 11 Homo sapiens 97-104 20055894-12 2010 This effect is produced through vitamin D response elements (VDREs), located in the promoter regions of these genes, suggesting that LCA acts as a mild analogous of vitamin D, interacting with the vitamin D receptor. Vitamin D 32-41 vitamin D receptor Homo sapiens 197-215 20055894-12 2010 This effect is produced through vitamin D response elements (VDREs), located in the promoter regions of these genes, suggesting that LCA acts as a mild analogous of vitamin D, interacting with the vitamin D receptor. Vitamin D 165-174 vitamin D receptor Homo sapiens 197-215 20527229-2 2010 This tissue-specific expression of 24-OHase may act as a pivotal link between vitamin D status (25(OH)D3 level) and the anticancer effects of 1,25(OH)2D3. Vitamin D 78-87 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 35-43 19693091-1 2010 Vitamin D exhibits immunomodulatory and antiproliferative effects through vitamin D receptor (VDR) in chronic infections and cancers. Vitamin D 0-9 vitamin D receptor Homo sapiens 74-92 19693091-1 2010 Vitamin D exhibits immunomodulatory and antiproliferative effects through vitamin D receptor (VDR) in chronic infections and cancers. Vitamin D 0-9 vitamin D receptor Homo sapiens 94-97 20049159-1 2010 Mediated by binding to the high-affinity vitamin D receptor (VDR), vitamin D forms a heterodimer complex with the retinoid-X-receptor (RXR). Vitamin D 41-50 vitamin D receptor Homo sapiens 61-64 20049159-1 2010 Mediated by binding to the high-affinity vitamin D receptor (VDR), vitamin D forms a heterodimer complex with the retinoid-X-receptor (RXR). Vitamin D 41-50 retinoid X receptor alpha Homo sapiens 114-133 20049159-1 2010 Mediated by binding to the high-affinity vitamin D receptor (VDR), vitamin D forms a heterodimer complex with the retinoid-X-receptor (RXR). Vitamin D 41-50 retinoid X receptor alpha Homo sapiens 135-138 20049159-5 2010 RXRA polymorphisms, located 3" of the coding sequence, modified associations between specific vitamin D rich foods and RCC risk, while RXRA polymorphisms, located in introns 1 and 4, modified associations with specific calcium rich foods. Vitamin D 94-103 retinoid X receptor alpha Homo sapiens 0-4 20049159-6 2010 Results suggest that variants in the RXRA gene modified the associations observed between RCC risk and calcium and vitamin D intake. Vitamin D 115-124 retinoid X receptor alpha Homo sapiens 37-41 20204178-7 2010 The multiple effects of VDRAs on modulating serum Ca, parathyroid cell proliferation, and the expression of CaSR and PTH mRNA reflect the complex involvement of the vitamin D axis in regulating the mineral homeostasis system. Vitamin D 165-174 calcium-sensing receptor Rattus norvegicus 108-112 20871847-10 2010 In the active vitamin D group, we found a significant median percent decline in levels of GM-CSF (-62.9%, P < .0001), IFN-gamma (-38.9%, P < .0001), IL-4 (-50.8%, P = .001), IL-8 (-48.4%, P < .0001), and IL-10 (-70.4%, P < .0001). Vitamin D 14-23 interleukin 10 Homo sapiens 213-218 20003690-2 2010 The vitamin D receptor (VDR) gene has been studied as a candidate locus due to genetic polymorphisms that affects the activity of the receptor and subsequent downstream vitamin D-mediated effects. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 20003690-8 2010 CONCLUSIONS: The association of VDR polymorphisms with risk of TB observed in our analyses supports the hypothesis that vitamin D deficiency might play a role as risk factor during the development of TB. Vitamin D 120-129 vitamin D receptor Homo sapiens 32-35 19815438-1 2010 The rare genetic recessive disease, hereditary vitamin D resistant rickets (HVDRR), is caused by mutations in the vitamin D receptor (VDR) that result in resistance to the active hormone 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3) or calcitriol). Vitamin D 47-56 vitamin D receptor Homo sapiens 114-132 19815438-1 2010 The rare genetic recessive disease, hereditary vitamin D resistant rickets (HVDRR), is caused by mutations in the vitamin D receptor (VDR) that result in resistance to the active hormone 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3) or calcitriol). Vitamin D 47-56 vitamin D receptor Homo sapiens 77-80 19815438-10 2010 However, the V26M mutation inhibited VDR binding to a consensus vitamin D response element (VDRE). Vitamin D 64-73 vitamin D receptor Homo sapiens 37-40 20731116-3 2010 FGF-23 is shown to be an important phosphaturic hormone that inhibits hypercalcemic and hyperphosphatemic effects of elevated serum vitamin D concentrations. Vitamin D 132-141 fibroblast growth factor 23 Homo sapiens 0-6 19801650-1 2009 (23S)-25-Dehydro-1alpha(OH)-vitamin D(3)-26,23-lactone (MK) is an antagonist of the 1alpha,25(OH)(2)-vitamin D(3) (1,25D)/human nuclear vitamin D receptor (hVDR) transcription initiation complex, where the activation helix (i.e. helix-12) is closed. Vitamin D 28-37 vitamin D receptor Homo sapiens 136-154 19801650-1 2009 (23S)-25-Dehydro-1alpha(OH)-vitamin D(3)-26,23-lactone (MK) is an antagonist of the 1alpha,25(OH)(2)-vitamin D(3) (1,25D)/human nuclear vitamin D receptor (hVDR) transcription initiation complex, where the activation helix (i.e. helix-12) is closed. Vitamin D 28-37 vitamin D receptor Homo sapiens 156-160 19800081-4 2009 Vitamin D mediates its function through a single vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 49-67 19800081-4 2009 Vitamin D mediates its function through a single vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 69-72 19800081-5 2009 Polymorphisms of the VDR have major effects on vitamin D function and metabolism, and some VDR genotypes have been linked to osteoporosis and MS. Because the safety of high doses of vitamin D has not been established yet, vitamin D hasn"t been used in enough doses to increase the serum level to a desired therapeutic target. Vitamin D 47-56 vitamin D receptor Homo sapiens 21-24 19800081-5 2009 Polymorphisms of the VDR have major effects on vitamin D function and metabolism, and some VDR genotypes have been linked to osteoporosis and MS. Because the safety of high doses of vitamin D has not been established yet, vitamin D hasn"t been used in enough doses to increase the serum level to a desired therapeutic target. Vitamin D 182-191 vitamin D receptor Homo sapiens 91-94 19800081-5 2009 Polymorphisms of the VDR have major effects on vitamin D function and metabolism, and some VDR genotypes have been linked to osteoporosis and MS. Because the safety of high doses of vitamin D has not been established yet, vitamin D hasn"t been used in enough doses to increase the serum level to a desired therapeutic target. Vitamin D 182-191 vitamin D receptor Homo sapiens 91-94 20003316-2 2009 Vitamin D is now recognised as having pleiotropic roles beyond bone and mineral homeostasis, with the vitamin D receptor and metabolising machinery identified in multiple tissues. Vitamin D 0-9 vitamin D receptor Homo sapiens 102-120 19779013-0 2009 Human duodenum responses to vitamin D metabolites of TRPV6 and other genes involved in calcium absorption. Vitamin D 28-37 transient receptor potential cation channel subfamily V member 6 Homo sapiens 53-58 19524924-1 2009 Fibroblast growth factor-23 (FGF23) is a hormonal regulator of circulating phosphate and vitamin D levels. Vitamin D 89-98 fibroblast growth factor 23 Homo sapiens 0-27 19524924-1 2009 Fibroblast growth factor-23 (FGF23) is a hormonal regulator of circulating phosphate and vitamin D levels. Vitamin D 89-98 fibroblast growth factor 23 Homo sapiens 29-34 19647104-0 2009 Vitamin D receptor gene polymorphisms modulate the skeletal response to vitamin D supplementation in healthy girls. Vitamin D 72-81 vitamin D receptor Homo sapiens 0-18 19647104-3 2009 This study investigated whether the musculo-skeletal response to Vitamin D was modulated by polymorphisms in VDR gene. Vitamin D 65-74 vitamin D receptor Homo sapiens 109-112 19647104-12 2009 CONCLUSION: VDR gene polymorphisms influence the skeletal response to vitamin D supplementation in healthy adolescent girls. Vitamin D 70-79 vitamin D receptor Homo sapiens 12-15 19683963-6 2009 In particular, "hormone-like" FGF19, FGF21, and FGF23, were shown to be involved in glucose, lipid, bile acid, phosphate, and vitamin D metabolism but the mechanisms underlying their functions as metabolic regulators are still being defined. Vitamin D 126-135 fibroblast growth factor 23 Homo sapiens 48-53 19615888-1 2009 We have carried out melanoma case-control comparisons for six vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) and serum 25-hydroxyvitamin D(3) levels in order to investigate the role of vitamin D in melanoma susceptibility. Vitamin D 62-71 vitamin D receptor Homo sapiens 82-85 19900346-4 2009 Vitamin D is most well known for its role in bone health; however, the discovery of VDR on a wide variety of tissue types has also opened up roles for vitamin D far beyond traditional bone health. Vitamin D 151-160 vitamin D receptor Homo sapiens 84-87 19545951-7 2009 Vitamin D acts through two types of receptors: (i) the vitamin D receptor (VDR), a member of the steroid/thyroid hormone superfamily of transcription factors, and (ii) the MARRS (membrane associated, rapid response steroid binding) receptor, also known as Erp57/Grp58. Vitamin D 0-9 vitamin D receptor Homo sapiens 55-73 19545951-7 2009 Vitamin D acts through two types of receptors: (i) the vitamin D receptor (VDR), a member of the steroid/thyroid hormone superfamily of transcription factors, and (ii) the MARRS (membrane associated, rapid response steroid binding) receptor, also known as Erp57/Grp58. Vitamin D 0-9 vitamin D receptor Homo sapiens 75-78 20021806-0 2009 [Effect of vitamin D supplementation in early life on the expression of interleukin-10 and intercellular adhesion molecule-1 in rat asthma model]. Vitamin D 11-20 intercellular adhesion molecule 1 Rattus norvegicus 91-124 19758226-2 2009 Instead, it is proposed that the lower levels result from chronic infection with intracellular bacteria that dysregulate vitamin D metabolism by causing vitamin D receptor (VDR) dysfunction within phagocytes. Vitamin D 121-130 vitamin D receptor Homo sapiens 153-171 19758226-2 2009 Instead, it is proposed that the lower levels result from chronic infection with intracellular bacteria that dysregulate vitamin D metabolism by causing vitamin D receptor (VDR) dysfunction within phagocytes. Vitamin D 121-130 vitamin D receptor Homo sapiens 173-176 19667142-4 2009 On a genomic level, these pathways converge on regulatory modules, some of which contain VDR-binding sites, so-called vitamin D response elements (VDREs). Vitamin D 118-127 vitamin D receptor Homo sapiens 89-92 19667148-1 2009 BACKGROUND: Vitamin D analog, 1alpha-hydroxy-24-ethyl-cholecalciferol (1alpha(OH)D5), is a less toxic VDR agonist that suppresses proliferation of breast cancer cells in vitro and in vivo. Vitamin D 12-21 vitamin D receptor Homo sapiens 102-105 19667166-6 2009 Thus, impairment of antimitogenic, proapoptotic and prodifferentiating signaling from the 1,25(OH)2D3-activated vitamin D receptor (VDR) and from the CaR in vitamin D and calcium insufficiency has been implicated in the pathogenesis of the aforementioned types of cancer. Vitamin D 112-121 vitamin D receptor Homo sapiens 132-135 19667166-7 2009 1,25(OH)2D3 and calcium interact in modulating cell growth in different ways: (i) Signaling pathways from the VDR and the CaR converge on the same downstream elements, e.g. of the canonical Wnt pathway; (ii) high extracellular calcium modulates extrarenal vitamin D metabolism in favor of higher local steady-state concentrations of 1,25(OH)2D3; (iii) 1,25(OH)2D3 may up-regulate expression of the CaR and thus augment CaR-mediated antiproliferative responses to high extracellular Ca2+. Vitamin D 256-265 vitamin D receptor Homo sapiens 110-113 19184092-4 2009 Vitamin D-deficient diet reverses the shortening of life span in klotho(-/-) mice. Vitamin D 0-9 klotho Mus musculus 65-71 19184092-12 2009 Vitamin D-deficient diet reversed the enhanced Ca(2+) entry and annexin V-binding of klotho(-/-) erythrocytes. Vitamin D 0-9 klotho Mus musculus 85-91 19184092-13 2009 The present observations reveal a novel function of Klotho, i.e., the at least partially vitamin D-dependent regulation of cytosolic Ca(2+) activity in and suicidal death of erythrocytes. Vitamin D 89-98 klotho Mus musculus 52-58 19546009-2 2009 FGF23 is produced by osteocytes in bone and acts on the kidney to inhibit 1alpha-hydroxylation of vitamin D and promote phosphorus excretion. Vitamin D 98-107 fibroblast growth factor 23 Mus musculus 0-5 19393206-5 2009 We conclude that polymorphisms of the VDR have major effects on vitamin D function and metabolism, and should therefore be assessed in studies on vitamin D and MS. Vitamin D 64-73 vitamin D receptor Homo sapiens 38-41 19393206-5 2009 We conclude that polymorphisms of the VDR have major effects on vitamin D function and metabolism, and should therefore be assessed in studies on vitamin D and MS. Vitamin D 146-155 vitamin D receptor Homo sapiens 38-41 19448403-5 2009 Recent studies on estrogen and vitamin D, and their receptors (ERalpha/beta, VDR) support now the idea that non-genomic and genomic effects may integrate in a unique mode of action of nuclear receptor ligands, in which the non-genomic effects constitute signaling pathways required for the effects at the genome level. Vitamin D 31-40 vitamin D receptor Homo sapiens 77-80 19483273-1 2009 FGF23; physiological action and molecular mechanism in the regulation of phosphate and vitamin D metabolism]. Vitamin D 87-96 fibroblast growth factor 23 Mus musculus 0-5 19483273-2 2009 Fibroblast growth factor (FGF) 23 is an endocrine hormone regulating the phosphate and vitamin D metabolism in the normal physiology. Vitamin D 87-96 fibroblast growth factor 23 Mus musculus 0-33 19483273-5 2009 However, it is suggested that the phenotype of the Klotho-deficient mice results from the disturbance in the phosphate and vitamin D metabolism. Vitamin D 123-132 klotho Mus musculus 51-57 19522996-2 2009 Objectives To study the effect of maternal intake of vitamin D during pregnancy on the emergence of asthma, allergic rhinitis (AR), and atopic eczema by the age of 5 years in children with HLA-DQB1-conferred susceptibility for type 1 diabetes. Vitamin D 53-62 major histocompatibility complex, class II, DQ beta 1 Homo sapiens 189-197 19018272-7 2009 CONCLUSIONS: These preliminary findings suggest that studies of maternal vitamin D status and birth size may need to take VDR genotype into account. Vitamin D 73-82 vitamin D receptor Homo sapiens 122-125 19225558-7 2009 These in vivo studies suggest that vitamin D has a pathologic role in regulating abnormal mineral ion metabolism and soft-tissue anomalies of klotho-deficient mice. Vitamin D 35-44 klotho Mus musculus 142-148 19255064-6 2009 Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3" UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status. Vitamin D 56-65 vitamin D receptor Homo sapiens 135-138 19255064-6 2009 Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3" UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status. Vitamin D 202-211 vitamin D receptor Homo sapiens 135-138 19298386-0 2009 Evidence for beta-lactoglobulin involvement in vitamin D transport in vivo--role of the gamma-turn (Leu-Pro-Met) of beta-lactoglobulin in vitamin D binding. Vitamin D 47-56 beta-lactoglobulin Bos taurus 13-31 19298386-0 2009 Evidence for beta-lactoglobulin involvement in vitamin D transport in vivo--role of the gamma-turn (Leu-Pro-Met) of beta-lactoglobulin in vitamin D binding. Vitamin D 138-147 beta-lactoglobulin Bos taurus 116-134 19298386-1 2009 Beta-lactoglobulin (LG) is a major bovine milk protein, containing a central calyx and a second exosite beyond the calyx to bind vitamin D; however, the biological function of LG in transporting vitamin D remains elusive. Vitamin D 129-138 beta-lactoglobulin Bos taurus 0-18 19298386-1 2009 Beta-lactoglobulin (LG) is a major bovine milk protein, containing a central calyx and a second exosite beyond the calyx to bind vitamin D; however, the biological function of LG in transporting vitamin D remains elusive. Vitamin D 195-204 beta-lactoglobulin Bos taurus 0-18 19254681-5 2009 RESULTS: Transgenic expression of VDR in the intestine of VDR-knockout mice normalized duodenal vitamin D-regulated calcium absorption as well as vitamin D-regulated calcium binding protein D9k and TRPV6 gene expression in the duodenum and proximal colon. Vitamin D 96-105 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 34-37 19254681-5 2009 RESULTS: Transgenic expression of VDR in the intestine of VDR-knockout mice normalized duodenal vitamin D-regulated calcium absorption as well as vitamin D-regulated calcium binding protein D9k and TRPV6 gene expression in the duodenum and proximal colon. Vitamin D 96-105 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 58-61 19254681-5 2009 RESULTS: Transgenic expression of VDR in the intestine of VDR-knockout mice normalized duodenal vitamin D-regulated calcium absorption as well as vitamin D-regulated calcium binding protein D9k and TRPV6 gene expression in the duodenum and proximal colon. Vitamin D 146-155 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 34-37 19049339-1 2009 Hereditary vitamin D-resistant rickets (HVDRR) is a rare recessive genetic disorder caused by mutations in the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 111-129 19049339-1 2009 Hereditary vitamin D-resistant rickets (HVDRR) is a rare recessive genetic disorder caused by mutations in the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 41-44 19429446-8 2009 These data suggest that VDR deficiency in mice is associated with decreased balance function, and may be relevant to poorer balance/posture control in humans with low levels of vitamin D. Vitamin D 177-186 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 24-27 19197242-5 2009 Sustained activation of Snail1 in transgenic mice provokes deficient osteoblast differentiation, which, together with the loss of vitamin D signalling in the bone, also impairs osteoclastogenesis. Vitamin D 130-139 snail family zinc finger 1 Mus musculus 24-30 19223536-10 2009 Our results of an association with the Fok1 VDR polymorphism further support a role of the vitamin D pathway in ovarian carcinogenesis. Vitamin D 91-100 vitamin D receptor Homo sapiens 44-47 19290791-3 2009 Given the importance of vitamin D in bone homeostasis, common polymorphisms in the vitamin D receptor gene were the first to be investigated as possible determinants of bone mass and fracture risk. Vitamin D 24-33 vitamin D receptor Homo sapiens 83-101 19063940-2 2009 Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates phosphate and vitamin D homeostasis. Vitamin D 91-100 fibroblast growth factor 23 Mus musculus 0-27 19063940-2 2009 Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates phosphate and vitamin D homeostasis. Vitamin D 91-100 fibroblast growth factor 23 Mus musculus 29-34 19116321-2 2009 Vitamin D binding protein (DBP) is the major carrier of vitamin D and its metabolites, but the role of DBP single nucleotide polymorphisms (SNPs) on 25(OH)D concentrations is unclear. Vitamin D 56-65 GC vitamin D binding protein Homo sapiens 0-25 19098224-4 2009 Consistent with this, VDR and SMRT are recruited to the vitamin D response element of the endogenous osteocalcin promoter in the absence of 1alpha,25-(OH)(2)D(3) in chromatin immunoprecipitation assays. Vitamin D 56-65 vitamin D receptor Homo sapiens 22-25 19818218-5 2009 The VDR complex binds in the nucleus to the vitamin D responsive element on the gene. Vitamin D 44-53 vitamin D receptor Homo sapiens 4-7 19400699-1 2009 Higher vitamin D exposure is hypothesized to prevent several cancers, possibly through genomic effects modulated by the vitamin D receptor (VDR), and autocrine/paracrine metabolism of the VDR"s ligand, 1alpha,25-(OH)(2)-vitamin D. Vitamin D 7-16 vitamin D receptor Homo sapiens 120-138 19400699-1 2009 Higher vitamin D exposure is hypothesized to prevent several cancers, possibly through genomic effects modulated by the vitamin D receptor (VDR), and autocrine/paracrine metabolism of the VDR"s ligand, 1alpha,25-(OH)(2)-vitamin D. Vitamin D 7-16 vitamin D receptor Homo sapiens 140-143 19400699-1 2009 Higher vitamin D exposure is hypothesized to prevent several cancers, possibly through genomic effects modulated by the vitamin D receptor (VDR), and autocrine/paracrine metabolism of the VDR"s ligand, 1alpha,25-(OH)(2)-vitamin D. Vitamin D 7-16 vitamin D receptor Homo sapiens 188-191 19400699-2 2009 Herein we review the background and evidence to date on associations between polymorphisms in VDR and selected genes in the vitamin D pathway in relation to colorectal, breast, and prostate cancer. Vitamin D 124-133 vitamin D receptor Homo sapiens 94-97 19139017-10 2009 Reverse transcription-PCR analysis showed significant up-regulation of VDR and E-cadherin, a downstream target of vitamin D action. Vitamin D 114-123 vitamin D receptor Homo sapiens 71-74 19287183-1 2009 It has recently been proposed that statins act as vitamin D analogs in binding the ubiquitously expressed vitamin D receptor, accounting for the perceived pleiotropic effects of statins (a reduction in cancer risk, prevention of organ transplant rejection and autoimmune disease). Vitamin D 50-59 vitamin D receptor Homo sapiens 106-124 19287183-3 2009 Vitamin D suppresses parathyroid hormone (PTH) secretion in part through its action on the vitamin D receptor. Vitamin D 0-9 vitamin D receptor Homo sapiens 91-109 19820750-1 2009 FGF23 is a recently identified hormone regulating mineral and vitamin D metabolism. Vitamin D 62-71 fibroblast growth factor 23 Homo sapiens 0-5 19820750-4 2009 FGF23 can also be used as a predictor of mortality as well as future development of refractory hyperparathyroidism in patients undergoing dialysis therapy, where FGF23 levels are markedly elevated in response to hyperphosphatemia and active vitamin D treatment. Vitamin D 241-250 fibroblast growth factor 23 Homo sapiens 0-5 19820750-4 2009 FGF23 can also be used as a predictor of mortality as well as future development of refractory hyperparathyroidism in patients undergoing dialysis therapy, where FGF23 levels are markedly elevated in response to hyperphosphatemia and active vitamin D treatment. Vitamin D 241-250 fibroblast growth factor 23 Homo sapiens 162-167 20010502-3 2009 The restriction polymorphisms in VDR gene could be involved in the modulation of vitamin D action and modulate the level of bone mineral density (BMD) and the risk to develop osteopenia and osteoporosis. Vitamin D 81-90 vitamin D receptor Homo sapiens 33-36 19399172-5 2009 Signals emanating from CD40 are important, as CD40(-/-) DCs treated with B7-DC XAb (DC(XAb)) activated DAP12, but failed to activate NFkappaB, and were not protected from cell death upon cytokine withdrawal or treatment with Vitamin D(3). Vitamin D 225-234 programmed cell death 1 ligand 2 Homo sapiens 73-78 20169924-1 2009 Vitamin D-binding protein (DBP) participates in the actin scavenger system, it is a carrier of vitamin D and its derivatives, it manifests the capacity to bind mainly monounsaturated and saturated fatty acids, it binds to the surface of several cells and enhances chemotactic activity of C5a of the complement. Vitamin D 95-104 GC vitamin D binding protein Homo sapiens 0-25 19282648-3 2009 alpha-Klotho, acting as a cofactor for FGF23, is also a major regulator of vitamin D biosynthesis and phosphate reabsorption in the kidney. Vitamin D 75-84 fibroblast growth factor 23 Mus musculus 39-44 24410609-1 2008 "Vitamin D" is a generic term for a family of secosteroids, members of which bind to the vitamin D receptor. Vitamin D 1-10 vitamin D receptor Homo sapiens 89-107 18709640-0 2008 Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding. Vitamin D 56-65 vitamin D receptor Homo sapiens 189-192 18709640-0 2008 Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding. Vitamin D 155-164 vitamin D receptor Homo sapiens 189-192 18709640-2 2008 Many mechanisms of action for vitamin D have been proposed, with some of them initiating via its binding to the vitamin D receptor (VDR). Vitamin D 30-39 vitamin D receptor Homo sapiens 112-130 18709640-2 2008 Many mechanisms of action for vitamin D have been proposed, with some of them initiating via its binding to the vitamin D receptor (VDR). Vitamin D 30-39 vitamin D receptor Homo sapiens 132-135 18709640-7 2008 The evidence of interaction we report here further supports the inverse association between vitamin D mediated through binding to the VDR. Vitamin D 92-101 vitamin D receptor Homo sapiens 134-137 19014363-5 2008 In fact, it is known that VDR is a transcription factor, and that in vitamin-D-depleted animals, VDR is largely localized in the cell nucleus. Vitamin D 69-78 vitamin D receptor Homo sapiens 97-100 18597628-0 2008 Vitamin D depletion induces RANKL-mediated osteoclastogenesis and bone loss in a rodent model. Vitamin D 0-9 TNF superfamily member 11 Homo sapiens 28-33 18767073-2 2008 The vitamin D metabolite 1alpha,25(OH)2D3 mediates growth inhibitory signaling via activation of the vitamin D receptor (VDR), a ligand dependent transcription factor. Vitamin D 4-13 vitamin D receptor Homo sapiens 101-119 18767073-2 2008 The vitamin D metabolite 1alpha,25(OH)2D3 mediates growth inhibitory signaling via activation of the vitamin D receptor (VDR), a ligand dependent transcription factor. Vitamin D 4-13 vitamin D receptor Homo sapiens 121-124 18767073-4 2008 Human mammary epithelial (HME) cells express VDR and CYP27b1 and undergo growth inhibition when exposed to physiological concentrations of 25(OH)D3, suggesting that autocrine or paracrine vitamin D signaling contributes to maintenance of differentiation and quiescence in the mammary epithelium. Vitamin D 188-197 vitamin D receptor Homo sapiens 45-48 18495457-9 2008 Similarly, genistein potentiated vitamin D"s inhibition of adipogenesis and induction of apoptosis in maturing preadipocytes by an enhanced expression of VDR (vitamin D receptor) protein. Vitamin D 33-42 vitamin D receptor Homo sapiens 154-157 18495457-9 2008 Similarly, genistein potentiated vitamin D"s inhibition of adipogenesis and induction of apoptosis in maturing preadipocytes by an enhanced expression of VDR (vitamin D receptor) protein. Vitamin D 33-42 vitamin D receptor Homo sapiens 159-177 18729070-8 2008 FGF-23 acts to prevent widespread abnormal features by acting systemically to regulate phosphate homeostasis and vitamin D metabolism. Vitamin D 113-122 fibroblast growth factor 23 Mus musculus 0-6 18824104-0 2008 A novel SNP in a vitamin D response element of the CYP24A1 promoter reduces protein binding, transactivation, and gene expression. Vitamin D 17-26 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 51-58 18824104-5 2008 Here we report the identification of six novel SNPs in the human CYP24A1 promoter, including one at nucleotide -279 occurring within the distal vitamin D response element (VDRE2). Vitamin D 144-153 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 65-72 19132265-8 2008 During the summer time, vitamin D deficiency (S-25-OHD < or = 25 nmol/L) affected 28% of the population, being virtually twice as much during the winter time. Vitamin D 24-33 ribosomal protein S25 Homo sapiens 46-54 19132265-13 2008 By contrast, those participants taking vitamin D supplements presented higher S-25-OHD levels (summer = 69.64 nmol/L and winter = 55 nmol/L) than those not consuming it (summer = 36.83 nmol/L and winter = 25.82 nmol/L) (psummer =0.0003 and p winter < 0.001). Vitamin D 39-48 ribosomal protein S25 Homo sapiens 78-86 18832725-5 2008 Stimulation of the same cells with the vitamin D(3) monocyte differentiation inducer resulted in a clear increase of Hox-A10 and MafB transcripts, indicating the existence of a precise transactivation cascade involving vitamin D(3) receptor, Hox-A10, and MafB transcription factors. Vitamin D 39-48 vitamin D receptor Homo sapiens 219-240 18758137-7 2008 1alpha-Methyl-2alpha-(3-hydroxypropyl)-25-hydroxyvitamin D(3) improved the binding affinity for the mutant VDR(Arg274Leu), which causes hereditary vitamin D resistant rickets. Vitamin D 49-58 vitamin D receptor Homo sapiens 107-110 18602086-7 2008 Luciferase assays using mutated constructs revealed that the VDR-binding sites of DR3, DR4(I), MdC3, and DR4(III) contribute to the induction, indicating that these binding sites act as vitamin D response elements (VDREs). Vitamin D 186-195 vitamin D receptor Homo sapiens 61-64 18602086-7 2008 Luciferase assays using mutated constructs revealed that the VDR-binding sites of DR3, DR4(I), MdC3, and DR4(III) contribute to the induction, indicating that these binding sites act as vitamin D response elements (VDREs). Vitamin D 186-195 major histocompatibility complex, class II, DR beta 4 Homo sapiens 87-90 18602086-7 2008 Luciferase assays using mutated constructs revealed that the VDR-binding sites of DR3, DR4(I), MdC3, and DR4(III) contribute to the induction, indicating that these binding sites act as vitamin D response elements (VDREs). Vitamin D 186-195 ADAM metallopeptidase domain 23 Homo sapiens 95-99 18602086-7 2008 Luciferase assays using mutated constructs revealed that the VDR-binding sites of DR3, DR4(I), MdC3, and DR4(III) contribute to the induction, indicating that these binding sites act as vitamin D response elements (VDREs). Vitamin D 186-195 major histocompatibility complex, class II, DR beta 4 Homo sapiens 105-108 18678710-0 2008 FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis. Vitamin D 62-71 fibroblast growth factor 23 Mus musculus 0-6 18678710-0 2008 FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis. Vitamin D 62-71 klotho Mus musculus 7-13 18678710-3 2008 We show that the signal transduction pathways initiated by FGF-23-Klotho prevent tissue atrophy by stimulating proliferation and preventing apoptosis caused by excessive systemic vitamin D. Vitamin D 179-188 fibroblast growth factor 23 Mus musculus 59-65 18678710-3 2008 We show that the signal transduction pathways initiated by FGF-23-Klotho prevent tissue atrophy by stimulating proliferation and preventing apoptosis caused by excessive systemic vitamin D. Vitamin D 179-188 klotho Mus musculus 66-72 18678710-4 2008 Because serum levels of active vitamin D are greatly increased upon genetic ablation of Fgf-23 or Klotho, we find that these molecules have a dual role in suppression of apoptotic actions of vitamin D through both negative regulation of 1alpha-hydroxylase expression and phosphoinositide-3 kinase-dependent inhibition of caspase activity. Vitamin D 31-40 fibroblast growth factor 23 Mus musculus 88-94 18678710-4 2008 Because serum levels of active vitamin D are greatly increased upon genetic ablation of Fgf-23 or Klotho, we find that these molecules have a dual role in suppression of apoptotic actions of vitamin D through both negative regulation of 1alpha-hydroxylase expression and phosphoinositide-3 kinase-dependent inhibition of caspase activity. Vitamin D 31-40 klotho Mus musculus 98-104 18678710-4 2008 Because serum levels of active vitamin D are greatly increased upon genetic ablation of Fgf-23 or Klotho, we find that these molecules have a dual role in suppression of apoptotic actions of vitamin D through both negative regulation of 1alpha-hydroxylase expression and phosphoinositide-3 kinase-dependent inhibition of caspase activity. Vitamin D 191-200 fibroblast growth factor 23 Mus musculus 88-94 18678710-4 2008 Because serum levels of active vitamin D are greatly increased upon genetic ablation of Fgf-23 or Klotho, we find that these molecules have a dual role in suppression of apoptotic actions of vitamin D through both negative regulation of 1alpha-hydroxylase expression and phosphoinositide-3 kinase-dependent inhibition of caspase activity. Vitamin D 191-200 klotho Mus musculus 98-104 18689389-4 2008 Over the past several decades, the biological sphere of influence of vitamin D(3), as defined by the tissue distribution of the VDR, has broadened at least 9-fold from the target organs required for calcium homeostasis (intestine, bone, kidney, and parathyroid). Vitamin D 69-78 vitamin D receptor Homo sapiens 128-131 18689389-7 2008 This article identifies the fundamentals of the vitamin D endocrine system, including its potential for contributions to good health in 5 physiologic arenas in which investigators have clearly documented new biological actions of 1alpha,25(OH)(2)D(3) through the VDR. Vitamin D 48-57 vitamin D receptor Homo sapiens 263-266 18559986-9 2008 These data suggest that the regulation of extracellular matrix mineralization by DMP1 is coupled to renal phosphate handling and vitamin D metabolism through a DMP1-dependent regulation of FGF23 production by osteocytes. Vitamin D 129-138 fibroblast growth factor 23 Mus musculus 189-194 18474231-5 2008 Vitamin D-resistant syndromes are caused by hereditary defects in metabolic activation of the hormone or by mutations in the vitamin D receptor, which binds the hormone with high affinity and regulates the expression of genes through zinc finger mediated DNA binding and protein-protein interaction. Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 125-143 18474231-12 2008 Vitamin D analogs which induce unusual structural conformations on the vitamin D receptor may have a variety of therapeutic indications. Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 71-89 18200516-0 2008 Vitamin D derivatives induce apoptosis and downregulate ICAM-1 levels in peripheral blood mononuclear cells of inflammatory bowel disease patients. Vitamin D 0-9 intercellular adhesion molecule 1 Homo sapiens 56-62 18200516-9 2008 The treatment with the vitamin D derivatives, alone or in combination with LPS or TNF-alpha, significantly decreases ICAM-1 levels both in healthy subjects and IBD patients. Vitamin D 23-32 intercellular adhesion molecule 1 Homo sapiens 117-123 18194670-1 2008 BACKGROUND: Gc-globulin or vitamin D binding protein is a highly expressed, multifunctional and polymorphic serum protein, which also serves as the major transporter for vitamin D metabolites in the circulation. Vitamin D 27-36 GC vitamin D binding protein Homo sapiens 12-23 18194670-17 2008 Under consideration of the available literature, these findings propose a participation of gc-globulin in hepatic vitamin D metabolism as well as in hepatic stellate cell stability and apoptosis as important mechanisms of liver regeneration. Vitamin D 114-123 GC vitamin D binding protein Homo sapiens 91-102 18212051-10 2008 The IGFBP-3 promoter activity induced by vitamin D, through VDR, was diminished in SRC-3(-/-) cells, suggesting an important role of SRC-3 in VDR-mediated transactivation of the IGFBP-3 gene. Vitamin D 41-50 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 60-63 18212051-10 2008 The IGFBP-3 promoter activity induced by vitamin D, through VDR, was diminished in SRC-3(-/-) cells, suggesting an important role of SRC-3 in VDR-mediated transactivation of the IGFBP-3 gene. Vitamin D 41-50 nuclear receptor coactivator 3 Mus musculus 83-88 18212051-10 2008 The IGFBP-3 promoter activity induced by vitamin D, through VDR, was diminished in SRC-3(-/-) cells, suggesting an important role of SRC-3 in VDR-mediated transactivation of the IGFBP-3 gene. Vitamin D 41-50 nuclear receptor coactivator 3 Mus musculus 133-138 18212051-10 2008 The IGFBP-3 promoter activity induced by vitamin D, through VDR, was diminished in SRC-3(-/-) cells, suggesting an important role of SRC-3 in VDR-mediated transactivation of the IGFBP-3 gene. Vitamin D 41-50 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 142-145 18467787-2 2008 The enzyme CYP24 inactivates vitamin D and is involved in its regulation. Vitamin D 29-38 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 11-16 18467787-14 2008 CONCLUSION: Mechanical stress and MAPK control CYP24 promoter activity in the presence of Vitamin D in MG63 osteoblast-like cells. Vitamin D 90-99 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 47-52 18379402-1 2008 STUDY DESIGN: Human lumbar anulus tissue and cultured human lumbar anulus cells were used in retrospective studies of the immunocytochemical localization of the vitamin D receptor (VDR) in disc tissue, and of the in vitro effects of the active metabolite of vitamin D, 1,25(OH)2D3, on anulus cell proliferation, cytokine, and proteoglycan (PG) production. Vitamin D 161-170 vitamin D receptor Homo sapiens 181-184 18182164-3 2008 Gel shift analysis indicated that GA reduced vitamin D-mediated DNA binding activity of the vitamin D receptor (VDR). Vitamin D 45-54 vitamin D receptor Homo sapiens 92-110 18182164-3 2008 Gel shift analysis indicated that GA reduced vitamin D-mediated DNA binding activity of the vitamin D receptor (VDR). Vitamin D 45-54 vitamin D receptor Homo sapiens 112-115 18334925-1 2008 INTRODUCTION: Vitamin D-binding protein (also called DBP or Gc-globulin) is recognized as a multifunctional protein involved in the action scavenger system, the transport of vitamin D sterols, and the modulation of immune and inflammatory responses. Vitamin D 174-183 GC vitamin D binding protein Homo sapiens 14-39 18083724-15 2008 Calcium and vitamin D prescription was significantly increased in the intervention group over the control group (IRR = 1.64 [1.23, 2.18] P<0.01). Vitamin D 12-21 insulin receptor related receptor Homo sapiens 113-116 18177265-2 2008 The klotho gene encodes a single-pass transmembrane protein that binds to multiple fibroblast growth factor (FGF) receptors and functions as a co-receptor for FGF23, a bone-derived hormone that suppresses phosphate reabsorption and vitamin D biosynthesis in the kidney. Vitamin D 232-241 klotho Mus musculus 4-10 18177265-2 2008 The klotho gene encodes a single-pass transmembrane protein that binds to multiple fibroblast growth factor (FGF) receptors and functions as a co-receptor for FGF23, a bone-derived hormone that suppresses phosphate reabsorption and vitamin D biosynthesis in the kidney. Vitamin D 232-241 fibroblast growth factor 23 Mus musculus 159-164 18177265-6 2008 Thus, understanding of Klotho protein function is expected to provide new insights into the molecular basis for aging, phosphate/vitamin D metabolism, cancer and stem cell biology. Vitamin D 129-138 klotho Mus musculus 23-29 18565252-13 2008 Treatment of L OA osteoblasts with osteotropic factors revealed that the OPG/RANKL mRNA expression ratio was significantly reduced by vitamin D(3) and significantly increased by TNF-alpha, PTH and PGE(2), while IL-1Beta demonstrated no effect. Vitamin D 134-143 TNF superfamily member 11 Homo sapiens 77-82 17878606-4 2008 In addition, FGF23 was shown to be produced by bone and regulate phosphate and vitamin D metabolism. Vitamin D 79-88 fibroblast growth factor 23 Homo sapiens 13-18 18497440-2 2008 Vitamin D is a prohormone which is converted into its active hormonal form 1, 25 (OH)D2 D, 1, 25 (OH)D2 D activates its cellular receptor (VDR) which activate target genes to engender its biological actions. Vitamin D 0-9 vitamin D receptor Homo sapiens 139-142 18266602-4 2008 These data provide preliminary evidence of associations of VDR polymorphisms with the risk of ALRI (predominantly viral bronchiolitis) in young children, consistent with a potential role of vitamin D in the immune response to respiratory tract infection. Vitamin D 190-199 vitamin D receptor Homo sapiens 59-62 18491455-3 2008 Vitamin D exerts its effects through the Vitamin D Receptor, coded for by a gene showing several polymorphisms associated with a variety of diseases and differential responses to Vitamin D. Vitamin D 0-9 vitamin D receptor Homo sapiens 41-59 18254883-2 2008 Recent studies, predominantly using the mouse 3T3-L1 pre-adipocyte cell culture model, have shown that the role of vitamin D in inhibiting adipogenesis is mediated at the molecular level through a vitamin D receptor (VDR)-dependent inhibition of CCAAT enhancer binding protein-alpha (C/EBP alpha) and peroxisome proliferator-activated receptor-gamma (PPAR gamma) expression and a decrease in PPAR gamma transactivating activity in the pre-adipocyte. Vitamin D 115-124 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 197-215 18254883-2 2008 Recent studies, predominantly using the mouse 3T3-L1 pre-adipocyte cell culture model, have shown that the role of vitamin D in inhibiting adipogenesis is mediated at the molecular level through a vitamin D receptor (VDR)-dependent inhibition of CCAAT enhancer binding protein-alpha (C/EBP alpha) and peroxisome proliferator-activated receptor-gamma (PPAR gamma) expression and a decrease in PPAR gamma transactivating activity in the pre-adipocyte. Vitamin D 115-124 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 217-220 18290711-8 2007 The functional characterization of the patient"s VDR reflected the localization of the mutation (18 different ones described to date), thus providing vital information about the structure-function relationship in the human VDR and the essentiality of the VDR as the mediator of vitamin D action. Vitamin D 278-287 vitamin D receptor Homo sapiens 49-52 18290711-8 2007 The functional characterization of the patient"s VDR reflected the localization of the mutation (18 different ones described to date), thus providing vital information about the structure-function relationship in the human VDR and the essentiality of the VDR as the mediator of vitamin D action. Vitamin D 278-287 vitamin D receptor Homo sapiens 223-226 18290711-8 2007 The functional characterization of the patient"s VDR reflected the localization of the mutation (18 different ones described to date), thus providing vital information about the structure-function relationship in the human VDR and the essentiality of the VDR as the mediator of vitamin D action. Vitamin D 278-287 vitamin D receptor Homo sapiens 223-226 18290714-7 2007 In the TRPV6 gene, these enhancers were all located within 5 kb of the transcriptional start site (TSS), and each contained one or more vitamin D regulatory elements (VDREs). Vitamin D 136-145 transient receptor potential cation channel subfamily V member 6 Homo sapiens 7-12 18290715-1 2007 The vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds with high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X receptor (RXR) heterodimeric partner to recognize vitamin D responsive elements (VDREs) in target genes. Vitamin D 4-13 vitamin D receptor Homo sapiens 109-127 18290715-1 2007 The vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds with high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X receptor (RXR) heterodimeric partner to recognize vitamin D responsive elements (VDREs) in target genes. Vitamin D 4-13 vitamin D receptor Homo sapiens 129-132 18290715-1 2007 The vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds with high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X receptor (RXR) heterodimeric partner to recognize vitamin D responsive elements (VDREs) in target genes. Vitamin D 4-13 retinoid X receptor alpha Homo sapiens 154-173 18290715-1 2007 The vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds with high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X receptor (RXR) heterodimeric partner to recognize vitamin D responsive elements (VDREs) in target genes. Vitamin D 4-13 retinoid X receptor alpha Homo sapiens 175-178 18290715-1 2007 The vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds with high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X receptor (RXR) heterodimeric partner to recognize vitamin D responsive elements (VDREs) in target genes. Vitamin D 37-46 vitamin D receptor Homo sapiens 109-127 18290715-1 2007 The vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds with high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X receptor (RXR) heterodimeric partner to recognize vitamin D responsive elements (VDREs) in target genes. Vitamin D 37-46 vitamin D receptor Homo sapiens 129-132 18290715-1 2007 The vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds with high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X receptor (RXR) heterodimeric partner to recognize vitamin D responsive elements (VDREs) in target genes. Vitamin D 37-46 retinoid X receptor alpha Homo sapiens 154-173 18290715-1 2007 The vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], binds with high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X receptor (RXR) heterodimeric partner to recognize vitamin D responsive elements (VDREs) in target genes. Vitamin D 37-46 retinoid X receptor alpha Homo sapiens 175-178 18290716-1 2007 Tissue availability of the active vitamin D metabolite, 1,25-dihydroxyvitamin D [1,25(OH)(2)D] is dependent on expression of the activating enzyme 1alpha-hydroxylase (CYP27b1) and its catabolic counterpart 24-hydroxylase (CYP24). Vitamin D 34-43 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 222-227 18290716-9 2007 In either case, the 1,25(OH)(2)D ligand is required for the VDR to heterodimerize with the retinoid x receptor and compete away the dominant-negative acting, heterogeneous nuclear ribonucleoprotein (hnRNP)-related, vitamin D response element-binding proteins that inhibit hormone-directed transactivation of genes. Vitamin D 215-224 vitamin D receptor Homo sapiens 60-63 18290729-1 2007 Since the discovery of the vitamin D receptor (VDR) in mammary cells, the role of the vitamin D signaling pathway in normal glandular function and in breast cancer has been extensively explored. Vitamin D 27-36 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 47-50 17710231-6 2007 Taken together, our findings provide what we believe to be the first evidence that loss-of-function mutations in human KL impair FGF23 bioactivity, underscoring the essential role of KL in FGF23-mediated phosphate and vitamin D homeostasis in humans. Vitamin D 218-227 klotho Homo sapiens 119-121 17710231-6 2007 Taken together, our findings provide what we believe to be the first evidence that loss-of-function mutations in human KL impair FGF23 bioactivity, underscoring the essential role of KL in FGF23-mediated phosphate and vitamin D homeostasis in humans. Vitamin D 218-227 fibroblast growth factor 23 Homo sapiens 129-134 17644135-4 2007 Vitamin D receptor expression was examined by Western immunoblot analysis after incubating the cells with 250 to 800 nM vitamin D, 10 to 70 nM testosterone, 2 nM calcium or a combination of the 3 products. Vitamin D 120-129 vitamin D receptor Homo sapiens 0-18 17644135-9 2007 Sequential concentrations of vitamin D increased vitamin D receptor expression intensity. Vitamin D 29-38 vitamin D receptor Homo sapiens 49-67 17644135-10 2007 Simultaneous addition of vitamin D and testosterone decreased the vitamin D receptor signal, as did testosterone alone. Vitamin D 25-34 vitamin D receptor Homo sapiens 66-84 17644135-11 2007 Delayed administration of vitamin D 5 hours after testosterone showed the return of vitamin D receptor expression. Vitamin D 26-35 vitamin D receptor Homo sapiens 84-102 17681143-1 2007 klotho was first described as an aging gene and was later shown to be a regulator of phosphate and vitamin D metabolism, acting as a coreceptor for FGF23. Vitamin D 99-108 klotho Homo sapiens 0-6 17681143-1 2007 klotho was first described as an aging gene and was later shown to be a regulator of phosphate and vitamin D metabolism, acting as a coreceptor for FGF23. Vitamin D 99-108 fibroblast growth factor 23 Homo sapiens 148-153 17342072-1 2007 BACKGROUND: Vitamin D-binding protein (DBP) gene is well known for its function on glucose and vitamin D metabolism in human populations. Vitamin D 95-104 GC vitamin D binding protein Homo sapiens 12-37 17641030-5 2007 B cells expressed mRNAs for proteins involved in vitamin D activity, including 1 alpha-hydroxylase, 24-hydroxylase, and the vitamin D receptor, each of which was regulated by 1,25(OH)(2)D(3) and/or activation. Vitamin D 49-58 vitamin D receptor Homo sapiens 124-142 17982392-5 2007 Recently, fibroblast growth factor 23 (FGF23) has emerged as an important humoral factor regulating phosphate and vitamin D homeostasis. Vitamin D 114-123 fibroblast growth factor 23 Homo sapiens 10-37 17982392-5 2007 Recently, fibroblast growth factor 23 (FGF23) has emerged as an important humoral factor regulating phosphate and vitamin D homeostasis. Vitamin D 114-123 fibroblast growth factor 23 Homo sapiens 39-44 17556530-9 2007 Paradoxically, mutations in the VDR ligand-dependent transcriptional activation function-2 that abrogate vitD3-dependent stimulation through classical vitamin D response elements, do not reduce vitD3-mediated LTR transactivation. Vitamin D 151-160 vitamin D receptor Homo sapiens 32-35 17507731-2 2007 More extensive roles for vitamin D were suggested by the discovery of the vitamin D receptor (VDR) in tissues that are not involved in calcium and phosphate metabolism. Vitamin D 25-34 vitamin D receptor Homo sapiens 74-92 17507731-2 2007 More extensive roles for vitamin D were suggested by the discovery of the vitamin D receptor (VDR) in tissues that are not involved in calcium and phosphate metabolism. Vitamin D 25-34 vitamin D receptor Homo sapiens 94-97 17393546-4 2007 Here, we describe the synthesis and in vitro assessment of a photocaged VDR agonist specific to a mutant NHR that is associated with vitamin D-resistant rickets. Vitamin D 133-142 vitamin D receptor Homo sapiens 72-75 17408240-3 2007 The results obtained from this screening of our synthetic vitamin D analogues suggest that the CoA-recruiting activities play an important role in determining the biological activity of various vitamin D analogues and explain the discrepancies between the VDR binding affinity and their biological activity. Vitamin D 58-67 vitamin D receptor Homo sapiens 256-259 17408240-3 2007 The results obtained from this screening of our synthetic vitamin D analogues suggest that the CoA-recruiting activities play an important role in determining the biological activity of various vitamin D analogues and explain the discrepancies between the VDR binding affinity and their biological activity. Vitamin D 194-203 vitamin D receptor Homo sapiens 256-259 22461213-5 2007 Polymorphisms of VDR and ERalphaloci appear genetic determinants of their corresponding hormonal treatment response such as vitamin D and estrogens. Vitamin D 124-133 vitamin D receptor Homo sapiens 17-20 17482806-1 2007 Vitamin D is a seco-steroid hormone with multiple actions in the brain, mediated through the nuclear vitamin D receptor (VDR). Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 101-119 17482806-1 2007 Vitamin D is a seco-steroid hormone with multiple actions in the brain, mediated through the nuclear vitamin D receptor (VDR). Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 121-124 16949543-1 2007 Vitamin D receptor (VDR) mediates a wide variety of vitamin D actions through transcriptional controls of target genes as a ligand-dependent transcription factor. Vitamin D 52-61 vitamin D receptor Homo sapiens 0-18 16949543-1 2007 Vitamin D receptor (VDR) mediates a wide variety of vitamin D actions through transcriptional controls of target genes as a ligand-dependent transcription factor. Vitamin D 52-61 vitamin D receptor Homo sapiens 20-23 17224124-6 2007 Our findings validate the new model of CYP24A1, which can now be used to predict structural modifications for rational vitamin D drug design. Vitamin D 119-128 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 39-46 17506310-0 2007 [Regulation of phosphorus-vitamin D metabolism by FGF23]. Vitamin D 26-35 fibroblast growth factor 23 Homo sapiens 50-55 17082781-1 2007 It has long been known that the active metabolite of vitamin D, 1,25 dihydroxyvitamin D(3), stimulates differentiation and inhibits proliferation in epidermal keratinocytes through interaction with the vitamin D receptor (VDR). Vitamin D 53-62 vitamin D receptor Homo sapiens 202-220 17082781-1 2007 It has long been known that the active metabolite of vitamin D, 1,25 dihydroxyvitamin D(3), stimulates differentiation and inhibits proliferation in epidermal keratinocytes through interaction with the vitamin D receptor (VDR). Vitamin D 53-62 vitamin D receptor Homo sapiens 222-225 17082781-2 2007 VDR functions through the coordinate binding of vitamin D response elements in the DNA and specific coactivator proteins which help to initiate transcription. Vitamin D 48-57 vitamin D receptor Homo sapiens 0-3 17223545-6 2007 The results identify new features of vitamin D-regulated enhancers, including their locations at gene loci, the structure of the VDR binding sites located within, their modular nature and their functional activity. Vitamin D 37-46 vitamin D receptor Homo sapiens 129-132 17223547-1 2007 The relationship between the A-ring chair conformation of vitamin D compounds and their ability to bind the vitamin D receptor (VDR) has long attracted the attention of many researchers. Vitamin D 58-67 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 108-126 17223547-1 2007 The relationship between the A-ring chair conformation of vitamin D compounds and their ability to bind the vitamin D receptor (VDR) has long attracted the attention of many researchers. Vitamin D 58-67 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 128-131 17223547-4 2007 In an attempt to verify the conformation of vitamin D compounds required for binding the VDR we prepared analog 4, characterized by the presence of an axial 1alpha-hydroxy group. Vitamin D 44-53 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 89-92 17257828-10 2007 Defining the role of hormone D-VDR binding will lead to a better understanding of the vitamin D signal transduction pathway. Vitamin D 86-95 vitamin D receptor Homo sapiens 31-34 17275288-9 2007 This data supports a role for 1,25D in heart ECM metabolism and suggests that MMPs and TIMPs expression may be modulated by vitamin D. Vitamin D 124-133 matrix metallopeptidase 2 Mus musculus 78-82 17280828-8 2007 In addition, calcitriol induced the Vitamin D metabolizing enzyme, 24-hydroxylase (cyp24) mRNA and enzyme activity similarly in naive and VDI cells as measured by RT-PCR and HPLC, respectively. Vitamin D 36-45 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 83-88 17368177-0 2007 New insights into Vitamin D sterol-VDR proteolysis, allostery, structure-function from the perspective of a conformational ensemble model. Vitamin D 18-27 vitamin D receptor Homo sapiens 35-38 17368177-1 2007 Recently, we have developed a Vitamin D sterol (VDS)-VDR conformational ensemble model. Vitamin D 30-39 vitamin D receptor Homo sapiens 53-56 17123805-0 2007 Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice. Vitamin D 12-21 fibroblast growth factor 23 Mus musculus 82-88 17123805-7 2007 In conclusion, our results indicate that the alterations in mineral and carbohydrate metabolism present in Fgf-23(-/-) mice require an intact vitamin D signaling pathway. Vitamin D 142-151 fibroblast growth factor 23 Mus musculus 107-113 17388667-2 2007 Circulating 25-hydroxyvitamin D3 (25[OH]D), the most commonly used index of vitamin D status, is converted to the active hormone 1,25 dihydroxyvitamin D3 (1,25[OH]2D), which, operating through the vitamin D receptor (VDR), inhibits in vitro cell proliferation, induces differentiation and apoptosis, and may protect against prostate cancer. Vitamin D 22-31 vitamin D receptor Homo sapiens 197-215 17388667-2 2007 Circulating 25-hydroxyvitamin D3 (25[OH]D), the most commonly used index of vitamin D status, is converted to the active hormone 1,25 dihydroxyvitamin D3 (1,25[OH]2D), which, operating through the vitamin D receptor (VDR), inhibits in vitro cell proliferation, induces differentiation and apoptosis, and may protect against prostate cancer. Vitamin D 22-31 vitamin D receptor Homo sapiens 217-220 17388667-4 2007 Few studies have explored the joint association of circulating vitamin D levels with VDR polymorphisms. Vitamin D 63-72 vitamin D receptor Homo sapiens 85-88 17388667-16 2007 Moreover, vitamin D status, measured by 25(OH)D in plasma, interacts with the VDR FokI polymorphism and modifies prostate cancer risk. Vitamin D 10-19 vitamin D receptor Homo sapiens 78-81 17347552-4 2007 Vitamin D-binding protein (DBP) binds, transports and activates vitamin D, which plays a major role in calcium homeostasis and bone turnover. Vitamin D 64-73 GC vitamin D binding protein Homo sapiens 0-25 17046242-7 2007 These Vitamin D analogs did not change the expression of Vitamin D receptor (VDR) up to 10nM, but stimulated CYP24A1 expression in a dose-dependent manner with the potency in the order of 1,25-dihydroxyvitamin D(3)>1,25-dihydroxyvitamin D(2)=19-nor-1,25-dihydroxyvitamin D(2). Vitamin D 6-15 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 109-116 17046242-8 2007 These results suggest that the differential effect of Vitamin D analogs on stimulating intestinal and Caco-2 calcium transport may be in part due to its different effect on stimulating CALB3 and TRPV6 mRNA expression. Vitamin D 54-63 transient receptor potential cation channel subfamily V member 6 Homo sapiens 195-200 17237289-4 2007 This study examines the potential synergistic effect of SPARC and vitamin D, which up-regulates VDR, in enhancing chemotherapy response in colorectal cancer. Vitamin D 66-75 vitamin D receptor Homo sapiens 96-99 17687191-1 2007 BACKGROUND: The vitamin D receptor (VDR) is involved in the regulation of renin expression and vitamin D analogs down-regulated renin mRNA expression in As4.1 cells. Vitamin D 16-25 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 36-39 17507873-1 2007 Isoflavonoids exert a regulatory function on the expression of cytochrome P450 enzymes and also up-regulate the vitamin D(3) receptor (VDR) on cancer cells, which increase their sensitivity to 1,25-dihydroxyvitamin D(3) , the hormonally active form of vitamin D(3) . Vitamin D 112-121 vitamin D receptor Homo sapiens 135-138 17507873-2 2007 Isoflavonoids are also able to raise the serum level of the active form of vitamin D(3) due to their inhibitory activity on CYP24, the enzyme involved in the degradation of 1,25-dihydroxyvitamin D(3) and its precursor 25-OH-D(3) to inactive compounds. Vitamin D 75-84 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 124-129 17071612-1 2006 Clinically apparent hereditary vitamin D-resistant rickets (HVDRR) usually results from a loss of function mutation in the vitamin D receptor (VDR). Vitamin D 31-40 vitamin D receptor Homo sapiens 123-141 17071612-1 2006 Clinically apparent hereditary vitamin D-resistant rickets (HVDRR) usually results from a loss of function mutation in the vitamin D receptor (VDR). Vitamin D 31-40 vitamin D receptor Homo sapiens 61-64 17071612-3 2006 Hormone resistance resulted from constitutive overexpression of heterogeneous nuclear ribonucleoprotein (hnRNP) that competed with a normally functioning VDR-retinoid X receptor (RXR) dimer for binding to the vitamin D response element (VDRE). Vitamin D 209-218 retinoid X receptor alpha Homo sapiens 154-177 17071612-3 2006 Hormone resistance resulted from constitutive overexpression of heterogeneous nuclear ribonucleoprotein (hnRNP) that competed with a normally functioning VDR-retinoid X receptor (RXR) dimer for binding to the vitamin D response element (VDRE). Vitamin D 209-218 retinoid X receptor alpha Homo sapiens 179-182 17071612-5 2006 When overexpressed in vitamin D-responsive cells, cDNAs for both hnRNPC1 and hnRNPC2 inhibited VDR-VDRE-directed transactivation (28 and 43%, respectively; both p < 0.005). Vitamin D 22-31 vitamin D receptor Homo sapiens 95-98 17071612-7 2006 Chromatin immunoprecipitation of nucleoproteins bound to the transcriptionally active 1,25-dihydroxy vitamin D-driven CYP24 promoter revealed the presence of REBiP in vitamin D-responsive human cells and indicated that the normal pattern of 1,25-dihydroxy vitamin D-initiated cyclical movement of the VDR on and off the VDRE is legislated by competitive, reciprocal occupancy of the VDRE by hnRNP C1/C2. Vitamin D 101-110 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 118-123 17071612-7 2006 Chromatin immunoprecipitation of nucleoproteins bound to the transcriptionally active 1,25-dihydroxy vitamin D-driven CYP24 promoter revealed the presence of REBiP in vitamin D-responsive human cells and indicated that the normal pattern of 1,25-dihydroxy vitamin D-initiated cyclical movement of the VDR on and off the VDRE is legislated by competitive, reciprocal occupancy of the VDRE by hnRNP C1/C2. Vitamin D 101-110 vitamin D receptor Homo sapiens 301-304 17148678-0 2006 Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals. Vitamin D 20-29 fibroblast growth factor 23 Mus musculus 96-102 17148678-5 2006 In addition, loss of vitamin D activities from Fgf-23-/- mice reverses the severe hyperphosphatemia to hypophosphatemia, attributable to increased urinary phosphate wasting in Fgf-23-/-/1alpha(OH)ase-/- mice, possibly as a consequence of decreased expression of NaPi2a. Vitamin D 21-30 fibroblast growth factor 23 Mus musculus 47-53 17148678-5 2006 In addition, loss of vitamin D activities from Fgf-23-/- mice reverses the severe hyperphosphatemia to hypophosphatemia, attributable to increased urinary phosphate wasting in Fgf-23-/-/1alpha(OH)ase-/- mice, possibly as a consequence of decreased expression of NaPi2a. Vitamin D 21-30 fibroblast growth factor 23 Mus musculus 176-182 17148678-6 2006 Ablation of vitamin D from Fgf-23-/- mice resulted in further reduction of total bone mineral content and bone mineral density and reversed ectopic calcification of skeleton and soft tissues, suggesting that abnormal mineral ion homeostasis and impaired skeletogenesis in Fgf-23-/- mice are mediated through enhanced vitamin D activities. Vitamin D 12-21 fibroblast growth factor 23 Mus musculus 27-33 17148678-6 2006 Ablation of vitamin D from Fgf-23-/- mice resulted in further reduction of total bone mineral content and bone mineral density and reversed ectopic calcification of skeleton and soft tissues, suggesting that abnormal mineral ion homeostasis and impaired skeletogenesis in Fgf-23-/- mice are mediated through enhanced vitamin D activities. Vitamin D 12-21 fibroblast growth factor 23 Mus musculus 272-278 17148678-6 2006 Ablation of vitamin D from Fgf-23-/- mice resulted in further reduction of total bone mineral content and bone mineral density and reversed ectopic calcification of skeleton and soft tissues, suggesting that abnormal mineral ion homeostasis and impaired skeletogenesis in Fgf-23-/- mice are mediated through enhanced vitamin D activities. Vitamin D 317-326 fibroblast growth factor 23 Mus musculus 27-33 17148678-7 2006 In conclusion, using genetic manipulation studies, we have provided evidence for an in vivo inverse correlation between Fgf-23 and vitamin D activities and for the severe skeletal and soft tissue abnormalities of Fgf-23-/- mice being mediated through vitamin D. Vitamin D 131-140 fibroblast growth factor 23 Mus musculus 120-126 17148678-7 2006 In conclusion, using genetic manipulation studies, we have provided evidence for an in vivo inverse correlation between Fgf-23 and vitamin D activities and for the severe skeletal and soft tissue abnormalities of Fgf-23-/- mice being mediated through vitamin D. Vitamin D 251-260 fibroblast growth factor 23 Mus musculus 120-126 17148678-7 2006 In conclusion, using genetic manipulation studies, we have provided evidence for an in vivo inverse correlation between Fgf-23 and vitamin D activities and for the severe skeletal and soft tissue abnormalities of Fgf-23-/- mice being mediated through vitamin D. Vitamin D 251-260 fibroblast growth factor 23 Mus musculus 213-219 17161336-3 2006 The generation of VDR deficient mice has expanded the knowledge on vitamin D from a calcium-regulating hormone to a humoral factor with extensive actions. Vitamin D 67-76 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 18-21 16860619-0 2006 The positive effect of dietary vitamin D intake on bone mineral density in men is modulated by the polyadenosine repeat polymorphism of the vitamin D receptor. Vitamin D 31-40 vitamin D receptor Homo sapiens 140-158 16860619-10 2006 However, the positive association between vitamin D intake and BMD was especially apparent among those with the L/L polyadenosine (A) VDR genotype explaining between 10 and 15% of the variability in BMD depending on site (p < 0.004). Vitamin D 42-51 vitamin D receptor Homo sapiens 134-137 16860619-13 2006 CONCLUSIONS: Our results indicate that the extent of positive association between dietary vitamin D intake and BMD in men is dependent on VDR polymorphism, a novel conceivable important gene-environmental interaction. Vitamin D 90-99 vitamin D receptor Homo sapiens 138-141 16946007-4 2006 The discovery in 1969 of the nuclear vitamin D receptor (VDR) for 1alpha,25(OH)2D3 initiated a two-decade-long proliferation of reports that collectively described the broad sphere of influence of the vitamin D endocrine system that is defined by the presence of the VDR in over 30 tissue/organs of man. Vitamin D 37-46 vitamin D receptor Homo sapiens 57-60 16946007-4 2006 The discovery in 1969 of the nuclear vitamin D receptor (VDR) for 1alpha,25(OH)2D3 initiated a two-decade-long proliferation of reports that collectively described the broad sphere of influence of the vitamin D endocrine system that is defined by the presence of the VDR in over 30 tissue/organs of man. Vitamin D 37-46 vitamin D receptor Homo sapiens 267-270 17156732-5 2006 In vitamin D target organs, inactivation of vitamin D is attributed to CYP24A1 which is transcriptionally induced by 1,25(OH)2D3 whose action is mediated by binding to its cognate nuclear receptor, the vitamin D receptor (VDR). Vitamin D 3-12 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 71-78 17156732-5 2006 In vitamin D target organs, inactivation of vitamin D is attributed to CYP24A1 which is transcriptionally induced by 1,25(OH)2D3 whose action is mediated by binding to its cognate nuclear receptor, the vitamin D receptor (VDR). Vitamin D 3-12 vitamin D receptor Homo sapiens 202-220 17156732-5 2006 In vitamin D target organs, inactivation of vitamin D is attributed to CYP24A1 which is transcriptionally induced by 1,25(OH)2D3 whose action is mediated by binding to its cognate nuclear receptor, the vitamin D receptor (VDR). Vitamin D 3-12 vitamin D receptor Homo sapiens 222-225 17156732-5 2006 In vitamin D target organs, inactivation of vitamin D is attributed to CYP24A1 which is transcriptionally induced by 1,25(OH)2D3 whose action is mediated by binding to its cognate nuclear receptor, the vitamin D receptor (VDR). Vitamin D 44-53 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 71-78 17156732-5 2006 In vitamin D target organs, inactivation of vitamin D is attributed to CYP24A1 which is transcriptionally induced by 1,25(OH)2D3 whose action is mediated by binding to its cognate nuclear receptor, the vitamin D receptor (VDR). Vitamin D 44-53 vitamin D receptor Homo sapiens 202-220 17156732-5 2006 In vitamin D target organs, inactivation of vitamin D is attributed to CYP24A1 which is transcriptionally induced by 1,25(OH)2D3 whose action is mediated by binding to its cognate nuclear receptor, the vitamin D receptor (VDR). Vitamin D 44-53 vitamin D receptor Homo sapiens 222-225 16732322-6 2006 Most importantly, we have identified a vitamin D responsive element (VDRE) in the promoter region of the human KSR-1 gene, to which VDR binds in a 1,25D-dependent manner, in vitro and in vivo. Vitamin D 39-48 vitamin D receptor Homo sapiens 69-72 17056528-10 2006 If this interpretation is correct, and humans have a similar bidirectional IL-10-dependent loop, then an IL-10-IL-10R pathway defect could abrogate the anti-inflammatory and neuro-protective functions of sunlight and vitamin D(3). Vitamin D 217-226 interleukin 10 Homo sapiens 75-80 17056528-10 2006 If this interpretation is correct, and humans have a similar bidirectional IL-10-dependent loop, then an IL-10-IL-10R pathway defect could abrogate the anti-inflammatory and neuro-protective functions of sunlight and vitamin D(3). Vitamin D 217-226 interleukin 10 Homo sapiens 105-110 17056528-10 2006 If this interpretation is correct, and humans have a similar bidirectional IL-10-dependent loop, then an IL-10-IL-10R pathway defect could abrogate the anti-inflammatory and neuro-protective functions of sunlight and vitamin D(3). Vitamin D 217-226 interleukin 10 receptor subunit alpha Homo sapiens 111-117 16886663-12 2006 The data clearly indicate that agents which inhibit the major vitamin D catabolizing enzyme, CYP24 (24 hydroxylase), potentiate calcitriol killing of prostate tumor cells in vitro and in vivo. Vitamin D 62-71 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 93-98 16709624-1 2006 BACKGROUND: Gc-globulin (vitamin D-binding protein) appears to have important functions in addition to its role as a carrier of vitamin D. Vitamin D 25-34 GC vitamin D binding protein Homo sapiens 12-23 16624609-7 2006 In this brief review, the role of vitamin D activation through its vitamin D receptor will serve as an introduction to the magnitude of the nutritional deficits in children, adults, and those with CKD. Vitamin D 34-43 vitamin D receptor Homo sapiens 67-85 16731043-3 2006 Recent in vivo genetic-manipulation studies have shown increased serum level of vitamin D and altered mineral-ion homeostasis in mice that lack either fibroblast growth factor 23 (Fgf23) or klotho (Kl) genes. Vitamin D 80-89 fibroblast growth factor 23 Mus musculus 151-178 16362534-2 2006 TRPV6 mRNA expression is strongly regulated by 1,25-dihydroxyvitamin D (1,25VD), the active hormonal form of vitamin D, in intestine and in Caco-2 cells, a human colon cancer cell line. Vitamin D 61-70 transient receptor potential cation channel subfamily V member 6 Homo sapiens 0-5 16868893-0 2006 Vitamin D-binding protein (DBP) gene polymorphism is associated with Graves" disease and the vitamin D status in a Polish population study. Vitamin D 93-102 GC vitamin D binding protein Homo sapiens 0-25 16868893-1 2006 OBJECTIVE: Vitamin D-binding protein (DBP) genetic variants have an influence on vitamin D status and, therefore, they may contribute to the development of autoimmune diseases. Vitamin D 81-90 GC vitamin D binding protein Homo sapiens 11-36 16753019-0 2006 Vitamin D-resistant rickets and type 1 diabetes in a child with compound heterozygous mutations of the vitamin D receptor (L263R and R391S): dissociated responses of the CYP-24 and rel-B promoters to 1,25-dihydroxyvitamin D3. Vitamin D 0-9 vitamin D receptor Homo sapiens 103-121 16753019-1 2006 UNLABELLED: We report here the first association between vitamin D-resistant rickets, alopecia, and type 1 diabetes in a child with compound heterozygous mutations in the VDR gene. Vitamin D 57-66 vitamin D receptor Homo sapiens 171-174 16481392-7 2006 The activation by 1,25(OH)(2)D(3) was abrogated after site-directed mutagenesis or deletion of the vitamin D response element (VDRE) in the ASBT promoter. Vitamin D 99-108 solute carrier family 10 member 2 Rattus norvegicus 140-144 16641675-1 2006 Vitamin D is a steroid hormone with many important functions in the brain, mediated through the nuclear vitamin D receptor. Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 104-122 16476762-2 2006 Oestrogens, androgens, corticosteroids, parathyroid hormone (PTH), vitamin D, and several cytokines exert their effects on bone modulating the OPG/RANKL system. Vitamin D 67-76 TNF superfamily member 11 Homo sapiens 147-152 16735766-1 2006 The aim of this study was to compare the bone mineral density (BMD) of two different treatment regimens in infants with nutritional vitamin D deficient rickets (VDR). Vitamin D 132-141 vitamin D receptor Homo sapiens 161-164 16596260-1 2006 The parathormone (PTH) production is controlled by calcium and vitamin D, which interact with the calcium-sensing receptor (CaSR) and vitamin D receptor (VDR), respectively. Vitamin D 63-72 vitamin D receptor Homo sapiens 134-152 16596260-1 2006 The parathormone (PTH) production is controlled by calcium and vitamin D, which interact with the calcium-sensing receptor (CaSR) and vitamin D receptor (VDR), respectively. Vitamin D 63-72 vitamin D receptor Homo sapiens 154-157 16597685-0 2006 Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D. Vitamin D 77-86 fibroblast growth factor 23 Mus musculus 0-27 16597685-6 2006 Overexpression of a dominant negative vitamin D receptor inhibited 1,25(OH)(2)D(3) stimulation of FGF23 promoter activity, and mutagenesis of the FGF23 promoter identified a vitamin D-responsive element (-1180 GGAACTcagTAACCT -1156) that is responsible for the vitamin D effects. Vitamin D 38-47 fibroblast growth factor 23 Mus musculus 98-103 16597685-6 2006 Overexpression of a dominant negative vitamin D receptor inhibited 1,25(OH)(2)D(3) stimulation of FGF23 promoter activity, and mutagenesis of the FGF23 promoter identified a vitamin D-responsive element (-1180 GGAACTcagTAACCT -1156) that is responsible for the vitamin D effects. Vitamin D 174-183 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 38-56 16597685-6 2006 Overexpression of a dominant negative vitamin D receptor inhibited 1,25(OH)(2)D(3) stimulation of FGF23 promoter activity, and mutagenesis of the FGF23 promoter identified a vitamin D-responsive element (-1180 GGAACTcagTAACCT -1156) that is responsible for the vitamin D effects. Vitamin D 174-183 fibroblast growth factor 23 Mus musculus 146-151 16597685-8 2006 The physiologic role of FGF23 may be to act as a counterregulatory phosphaturic hormone to maintain phosphate homeostasis in response to vitamin D. Vitamin D 137-146 fibroblast growth factor 23 Mus musculus 24-29 16365879-0 2006 UVB-induced production of 1,25-dihydroxyvitamin D3 and vitamin D activity in human keratinocytes pretreated with a sterol delta7-reductase inhibitor. Vitamin D 40-49 7-dehydrocholesterol reductase Homo sapiens 115-138 16365879-3 2006 In addition, epidermal keratinocytes contain the vitamin D receptor (VDR) and possess 25-hydroxylase and 1alpha-hydroxylase activity indicating that all components of the vitamin D system are present. Vitamin D 49-58 vitamin D receptor Homo sapiens 69-72 16365879-6 2006 Transfection experiments with a vitamin D response element containing construct confirmed VDR-dependent gene activation. Vitamin D 32-41 vitamin D receptor Homo sapiens 90-93 16614118-1 2006 Inherited variants of the vitamin D receptor (VDR) gene may influence cancer risk by altering the effect of vitamin D on cell growth and homeostasis. Vitamin D 26-35 vitamin D receptor Homo sapiens 46-49 16436465-0 2006 Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process. Vitamin D 77-86 fibroblast growth factor 23 Mus musculus 34-61 16436465-3 2006 Our results indicate a novel role of Fgf-23 in developing premature aging-like features through regulating vitamin D homeostasis. Vitamin D 107-116 fibroblast growth factor 23 Mus musculus 37-43 16427152-1 2006 Vitamin D is a steroid hormone with many important functions in the brain, mediated through the nuclear Vitamin D receptor (VDR). Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 104-122 16427152-1 2006 Vitamin D is a steroid hormone with many important functions in the brain, mediated through the nuclear Vitamin D receptor (VDR). Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 124-127 16427152-4 2006 Given the important role of Vitamin D and VDR in brain development and functioning, we hypothesized that several other important behavioural domains may be affected by disruption of the VDR gene in mice. Vitamin D 28-37 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 186-189 16613705-1 2006 OBJECTIVE: To explore the genetic susceptibility of children to vitamin D deficiency rickets through studying the association between Vitamin D receptor (VDR) gene polymorphism and vitamin D deficiency rickets. Vitamin D 64-73 vitamin D receptor Homo sapiens 134-152 16613705-1 2006 OBJECTIVE: To explore the genetic susceptibility of children to vitamin D deficiency rickets through studying the association between Vitamin D receptor (VDR) gene polymorphism and vitamin D deficiency rickets. Vitamin D 64-73 vitamin D receptor Homo sapiens 154-157 16613705-1 2006 OBJECTIVE: To explore the genetic susceptibility of children to vitamin D deficiency rickets through studying the association between Vitamin D receptor (VDR) gene polymorphism and vitamin D deficiency rickets. Vitamin D 181-190 vitamin D receptor Homo sapiens 134-152 16613705-1 2006 OBJECTIVE: To explore the genetic susceptibility of children to vitamin D deficiency rickets through studying the association between Vitamin D receptor (VDR) gene polymorphism and vitamin D deficiency rickets. Vitamin D 181-190 vitamin D receptor Homo sapiens 154-157 16613705-10 2006 CONCLUSIONS: There is an association between the VDR gene Fok I polymorphism and vitamin D deficiency rickets. Vitamin D 81-90 vitamin D receptor Homo sapiens 49-52 16406653-1 2006 Vitamin D signaling is dependent on the availability and turnover of the active Vitamin D receptor (VDR) ligand 1,25-dihydroxycholecalciferol and on the efficiency of VDR transactivation. Vitamin D 0-9 vitamin D receptor Homo sapiens 80-98 16406653-1 2006 Vitamin D signaling is dependent on the availability and turnover of the active Vitamin D receptor (VDR) ligand 1,25-dihydroxycholecalciferol and on the efficiency of VDR transactivation. Vitamin D 0-9 vitamin D receptor Homo sapiens 100-103 16406653-1 2006 Vitamin D signaling is dependent on the availability and turnover of the active Vitamin D receptor (VDR) ligand 1,25-dihydroxycholecalciferol and on the efficiency of VDR transactivation. Vitamin D 0-9 vitamin D receptor Homo sapiens 167-170 16516540-8 2006 Our findings suggest that CYP24A1 can activate and inactivate vitamin D prodrugs in skin and other target cells in vitro, offering the potential for treatment of hyperproliferative disorders such as psoriasis by topical administration of these prodrugs. Vitamin D 62-71 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 26-33 16339300-1 2006 BACKGROUND: Clinical assessment of vitamin D status often relies on measuring total circulating 25-hydroxyvitamin D3 (25OHD3), but much of each vitamin D metabolite is bound to plasma vitamin D-binding protein (DBP), such that the percentage of free vitamin is very low. Vitamin D 35-44 GC vitamin D binding protein Homo sapiens 184-209 16243370-3 2006 This effect is mediated via a negative Vitamin D response element (nVDREhPTHrP) within the human PTHrP gene and involves an interaction between nVDREhPTHrP and the Vitamin D receptor (VDR). Vitamin D 39-48 vitamin D receptor Homo sapiens 164-182 16243370-3 2006 This effect is mediated via a negative Vitamin D response element (nVDREhPTHrP) within the human PTHrP gene and involves an interaction between nVDREhPTHrP and the Vitamin D receptor (VDR). Vitamin D 39-48 vitamin D receptor Homo sapiens 68-71 15987715-9 2006 These findings support the idea that vitamin D-based therapies might be beneficial in the management of advanced prostate cancer, especially among patients who have higher MMP-9 and CPs activities. Vitamin D 37-46 matrix metallopeptidase 9 Homo sapiens 172-177 16848738-1 2006 The vitamin D receptor (VDR) is an endocrine member of the nuclear receptor superfamily and binds the biologically most active vitamin D metabolite, 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3). Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 16269453-9 2006 Hr binding to the VDR was eliminated by 1,25(OH)2D3, which recruited the coactivator vitamin D receptor-interacting protein 205 (DRIP205) to the VDR/vitamin D response element complex. Vitamin D 85-94 vitamin D receptor Homo sapiens 18-21 16269453-9 2006 Hr binding to the VDR was eliminated by 1,25(OH)2D3, which recruited the coactivator vitamin D receptor-interacting protein 205 (DRIP205) to the VDR/vitamin D response element complex. Vitamin D 85-94 mediator complex subunit 1 Homo sapiens 129-136 16269453-9 2006 Hr binding to the VDR was eliminated by 1,25(OH)2D3, which recruited the coactivator vitamin D receptor-interacting protein 205 (DRIP205) to the VDR/vitamin D response element complex. Vitamin D 85-94 vitamin D receptor Homo sapiens 145-148 16358222-4 2005 Klotho plays a critical role in the regulation of calcium and phosphorus homeostasis by negatively regulating active vitamin D synthesis. Vitamin D 117-126 klotho Homo sapiens 0-6 16002434-2 2005 The vitamin D receptor (VDR) is a ligand-regulated transcription factor that recognizes cognate vitamin D response elements (VDREs) formed by direct or everted repeats of PuG(G/T)TCA motifs separated by 3 or 6 bp (DR3 or ER6). Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 16239345-11 2005 We conclude that vitamin D-regulated relB transcription in DCs is controlled by chromatin remodeling by means of recruitment of complexes including HDAC3. Vitamin D 17-26 avian reticuloendotheliosis viral (v-rel) oncogene related B Mus musculus 37-41 16181450-8 2005 The active form of vitamin D, 1,25-dihydroxyvitamin D(3), exhibits antiproliferative and immunoregulatory effects via the vitamin D receptor, and thus is successfully used in the topical treatment of psoriasis. Vitamin D 19-28 vitamin D receptor Homo sapiens 122-140 15905882-0 2005 Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death. Vitamin D 0-9 beclin 1 Homo sapiens 64-72 16177194-10 2005 The expression of the mRNA for the VDR and the 1alpha-OHase was 37- and 6-fold higher, respectively, in the vitamin D-sufficient mice compared with the vitamin D-deficient mice. Vitamin D 108-117 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 35-38 16177194-10 2005 The expression of the mRNA for the VDR and the 1alpha-OHase was 37- and 6-fold higher, respectively, in the vitamin D-sufficient mice compared with the vitamin D-deficient mice. Vitamin D 152-161 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 35-38 16202933-9 2005 Vitamin D receptor is expressed in all calcium-regulated tissues, including the ovary; thus, calcium and vitamin D appear to be necessary for full ovarian function. Vitamin D 105-114 vitamin D receptor Homo sapiens 0-18 16046118-1 2005 1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the biologically active metabolite of Vitamin D(3), not only regulates bone and calcium metabolism but also exerts other biological activities, including immunomodulation via the nuclear Vitamin D receptor expressed in antigen-presenting cells and activated T cells. Vitamin D 84-93 vitamin D receptor Homo sapiens 233-251 16055325-5 2005 Along these lines we have recently proposed a Vitamin D sterol/VDR conformational ensemble model that posits the VDR contains two distinct, yet overlapping ligand binding sites, and that the potential differential stabilities of 1,25D and HL in these two pockets can be used to explain their different non-genomic signaling properties. Vitamin D 46-55 vitamin D receptor Homo sapiens 63-66 16055325-5 2005 Along these lines we have recently proposed a Vitamin D sterol/VDR conformational ensemble model that posits the VDR contains two distinct, yet overlapping ligand binding sites, and that the potential differential stabilities of 1,25D and HL in these two pockets can be used to explain their different non-genomic signaling properties. Vitamin D 46-55 vitamin D receptor Homo sapiens 113-116 16055325-9 2005 This model may provide new insights into how Vitamin D sterols that uncouple the unwanted hypercalcemic effect from attractive growth inhibitory/differentiation properties can do so by differentially stabilizing different subpopulations of VDR conformational ensemble members. Vitamin D 45-54 vitamin D receptor Homo sapiens 240-243 16279693-0 2005 [Regulatory effect of FGF23 on phosphate and vitamin D metabolism]. Vitamin D 45-54 fibroblast growth factor 23 Homo sapiens 22-27 16278149-1 2005 OBJECTIVE: Vitamin D has been shown to exert multiple immunomodulatory effects and is known to suppress T-cell activation by binding to the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 140-158 16278149-1 2005 OBJECTIVE: Vitamin D has been shown to exert multiple immunomodulatory effects and is known to suppress T-cell activation by binding to the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 160-163 16369193-4 2005 Actions of vitamin D are mediated by the binding of 1, 25-(OH)2D3 to a specific cytosolic/nuclear vitamin D receptor (VDR), a member of the steroid/thyroid hormone receptor superfamily. Vitamin D 11-20 vitamin D receptor Homo sapiens 98-116 16369193-4 2005 Actions of vitamin D are mediated by the binding of 1, 25-(OH)2D3 to a specific cytosolic/nuclear vitamin D receptor (VDR), a member of the steroid/thyroid hormone receptor superfamily. Vitamin D 11-20 vitamin D receptor Homo sapiens 118-121 15992766-1 2005 The vitamin D receptor (VDR) mediates the effects of 1,25(OH)(2)D(3), the active form of vitamin D. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 15885032-1 2005 FGF23 (fibroblast growth factor 23) is a novel phosphaturic factor that influences vitamin D metabolism and renal re-absorption of Pi. Vitamin D 83-92 fibroblast growth factor 23 Mus musculus 0-5 15885032-1 2005 FGF23 (fibroblast growth factor 23) is a novel phosphaturic factor that influences vitamin D metabolism and renal re-absorption of Pi. Vitamin D 83-92 fibroblast growth factor 23 Mus musculus 7-34 16076372-1 2005 Fibroblast growth factor 23 (FGF23) is a circulating factor that plays critical roles in phosphate and vitamin D metabolism, as evidenced by the fact that FGF23 missense mutations cause autosomal dominant hypophosphatemic rickets (ADHR). Vitamin D 103-112 fibroblast growth factor 23 Homo sapiens 0-27 16076372-1 2005 Fibroblast growth factor 23 (FGF23) is a circulating factor that plays critical roles in phosphate and vitamin D metabolism, as evidenced by the fact that FGF23 missense mutations cause autosomal dominant hypophosphatemic rickets (ADHR). Vitamin D 103-112 fibroblast growth factor 23 Homo sapiens 29-34 16076372-1 2005 Fibroblast growth factor 23 (FGF23) is a circulating factor that plays critical roles in phosphate and vitamin D metabolism, as evidenced by the fact that FGF23 missense mutations cause autosomal dominant hypophosphatemic rickets (ADHR). Vitamin D 103-112 fibroblast growth factor 23 Homo sapiens 155-160 15985530-5 2005 The induction occurred via a consensus vitamin D response element (VDRE) in the CAMP promoter that was bound by the vitamin D receptor (VDR). Vitamin D 39-48 vitamin D receptor Homo sapiens 116-134 15985530-5 2005 The induction occurred via a consensus vitamin D response element (VDRE) in the CAMP promoter that was bound by the vitamin D receptor (VDR). Vitamin D 39-48 vitamin D receptor Homo sapiens 67-70 15917335-3 2005 Several hypotheses were tested: that FGF-23 increases as renal function declines; is linearly associated with serum phosphate levels; is associated with increased phosphaturia independent of parathyroid hormone (PTH); and is associated with decreased calcitriol levels independent of renal function, hyperphosphatemia, and vitamin D stores. Vitamin D 323-332 fibroblast growth factor 23 Homo sapiens 37-43 15869926-12 2005 Thus, our results demonstrate that Fgf23 is independently regulated by phosphate and by vitamin D. Vitamin D 88-97 fibroblast growth factor 23 Mus musculus 35-40 15650022-0 2005 Molecular mechanism of the vitamin D antagonistic actions of (23S)-25-dehydro-1alpha-hydroxyvitamin D3-26,23-lactone depends on the primary structure of the carboxyl-terminal region of the vitamin d receptor. Vitamin D 27-36 vitamin D receptor Homo sapiens 189-207 15862832-7 2005 In addition, evidence that the model is consistent with the pH requirement for Vitamin D sterol-VDR crystallization will be presented. Vitamin D 79-88 vitamin D receptor Homo sapiens 96-99 15752725-8 2005 Based on these results, the enzyme(s) responsible for the epimerization of vitamin D(3) at C-3 are thought to be located in microsomes and different from cytochrome P450 and HSE. Vitamin D 75-84 complement C3 Homo sapiens 91-94 15863037-4 2005 FGF23 circulates in the bloodstream, and animal models demonstrate that FGF23 controls phosphate and Vitamin D homeostasis through the regulation of specific renal proteins. Vitamin D 101-110 fibroblast growth factor 23 Homo sapiens 72-77 15581603-4 2005 Renal VDR levels were significantly higher in the vitamin D-deficient mice fed the 0.47% calcium diet vs. the calcium-restricted diet, and were increased 5-fold by 1,25(OH)(2)D(3) when dietary calcium was present. Vitamin D 50-59 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 6-9 15838626-2 2005 Recently, fibroblast growth factor 23 (FGF-23) was reported as a phosphaturic and a causal factor of abnormal vitamin D metabolism. Vitamin D 110-119 fibroblast growth factor 23 Homo sapiens 10-37 15838626-2 2005 Recently, fibroblast growth factor 23 (FGF-23) was reported as a phosphaturic and a causal factor of abnormal vitamin D metabolism. Vitamin D 110-119 fibroblast growth factor 23 Homo sapiens 39-45 15838626-12 2005 These data suggested that FGF-23 is a possible causal factor for hypophosphatemia and abnormal vitamin D metabolism in MAS. Vitamin D 95-104 fibroblast growth factor 23 Homo sapiens 26-32 15489543-1 2005 The vitamin D receptor (VDR), a member of the nuclear receptor superfamily, mediates the biological actions of the active form of vitamin D, 1alpha,25-dihydroxyvitamin D(3). Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 15956805-3 2005 Since FGF-23 is associated also with vitamin D metabolism, we examined the changes of serum FGF-23 levels in chronic dialysis patients treated with intravenous calcitriol therapy. Vitamin D 37-46 fibroblast growth factor 23 Homo sapiens 6-12 15956805-11 2005 Extremely high levels of serum FGF-23 in these patients may be attributed, at least in part, to the cumulative dose of vitamin D. Vitamin D 119-128 fibroblast growth factor 23 Homo sapiens 31-37 15659793-8 2004 Osteocalcin gene expression was enhanced by VD/VD-R through the vitamin D-responsive element in the promoter. Vitamin D 64-73 vitamin D receptor Homo sapiens 47-51 15564440-5 2004 The vitamin D hormone (1,25-dihydroxy vitamin D(3)) regulates T helper cell (Th1) and dendritic cell function while inducing regulatory T-cell function. Vitamin D 4-13 negative elongation factor complex member C/D Homo sapiens 77-80 15544953-4 2004 A five-step inactivation pathway from 1alpha,25-(OH)(2)D(3) to calcitroic acid is attributed to a single multifunctional CYP, CYP24A1, which is transcriptionally induced in vitamin D target cells by the action of 1alpha,25-(OH)(2)D(3). Vitamin D 173-182 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 126-133 15522514-7 2004 The present study suggests that HSDs may catalyze the C-3 epimerization of vitamin D compounds and modulate their concentrations and biological activities in animals and humans. Vitamin D 75-84 complement C3 Homo sapiens 54-57 15474498-6 2004 In a mammalian two-hybrid system, S182D bound less avidly than wild-type or S182A hVDR to the retinoid X receptor (RXR) heterodimeric partner that co-mediates vitamin D responsive element recognition and transactivation. Vitamin D 159-168 vitamin D receptor Homo sapiens 82-86 15474498-6 2004 In a mammalian two-hybrid system, S182D bound less avidly than wild-type or S182A hVDR to the retinoid X receptor (RXR) heterodimeric partner that co-mediates vitamin D responsive element recognition and transactivation. Vitamin D 159-168 retinoid X receptor alpha Homo sapiens 94-113 15474498-6 2004 In a mammalian two-hybrid system, S182D bound less avidly than wild-type or S182A hVDR to the retinoid X receptor (RXR) heterodimeric partner that co-mediates vitamin D responsive element recognition and transactivation. Vitamin D 159-168 retinoid X receptor alpha Homo sapiens 115-118 15297458-1 2004 An earlier report in the literature indicated the vitamin D response element (VDRE) in the human parathyroid hormone (hPTH) promoter could be specifically bound by an unidentified transcription factor in addition to the vitamin D receptor (VDR) complex. Vitamin D 50-59 vitamin D receptor Homo sapiens 220-238 15297458-1 2004 An earlier report in the literature indicated the vitamin D response element (VDRE) in the human parathyroid hormone (hPTH) promoter could be specifically bound by an unidentified transcription factor in addition to the vitamin D receptor (VDR) complex. Vitamin D 50-59 vitamin D receptor Homo sapiens 78-81 15297458-8 2004 Furthermore, findings suggest that the repressive effects of vitamin D on hPTH gene transcription may involve displacement of NF-Y binding to the proximal site by the VDR heterodimer, which subsequently attenuates synergistic transactivation. Vitamin D 61-70 vitamin D receptor Homo sapiens 167-170 15252846-1 2004 The vitamin D receptor (VDR) may importantly modulate risk of colorectal cancer either independently or in conjunction with calcium and vitamin D intake. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 15377346-8 2004 Topical application of the vitamin D analogue calcipotriol under occlusion to involved psoriatic skin for 4 days resulted in an increase in AP-1 DNA binding activity, and an increase in the protein and mRNA expression of c-Fos, Fra-1 and c-Jun, together with a decrease in JunB protein and mRNA expression. Vitamin D 27-36 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 140-144 15377346-8 2004 Topical application of the vitamin D analogue calcipotriol under occlusion to involved psoriatic skin for 4 days resulted in an increase in AP-1 DNA binding activity, and an increase in the protein and mRNA expression of c-Fos, Fra-1 and c-Jun, together with a decrease in JunB protein and mRNA expression. Vitamin D 27-36 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 221-226 15377346-8 2004 Topical application of the vitamin D analogue calcipotriol under occlusion to involved psoriatic skin for 4 days resulted in an increase in AP-1 DNA binding activity, and an increase in the protein and mRNA expression of c-Fos, Fra-1 and c-Jun, together with a decrease in JunB protein and mRNA expression. Vitamin D 27-36 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 238-243 15322208-8 2004 However, VDR-deficient mice failed to develop experimental allergic asthma, suggesting an important role for the vitamin D endocrine system in the generation of Th2-driven inflammation in the lung. Vitamin D 113-122 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 9-12 15261298-1 2004 Compounds (6a-e) were synthesized by phosphorylation of hydrophobic perhydroindan derivatives derived from vitamin D(3), and were found to show strong inhibitory activity towards dual-specificity phosphatase Cdc25A (IC(50)=0.7-24.5 microM). Vitamin D 107-116 cell division cycle 25A Homo sapiens 208-214 15288775-0 2004 Rapid vitamin D-dependent PKC signaling shares features with estrogen-dependent PKC signaling in cartilage and bone. Vitamin D 6-15 protein kinase C, alpha Rattus norvegicus 26-29 15219879-8 2004 The effect of vitamin D on reproduction has been further endorsed by murine gene knockout models for 1alpha-hydroxylase and VDR, both of which are infertile. Vitamin D 14-23 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 124-127 15255308-4 2004 Additional susceptibility is conferred by genomic variants of the vitamin D system (vitamin D receptor and CYP1 alpha hydroxylase). Vitamin D 66-75 vitamin D receptor Homo sapiens 84-102 15055995-4 2004 Here, we report the crystal structures of VDR ligand binding domain bound to two vitamin D agonists of therapeutical interest, calcipotriol and seocalcitol, which are characterized by their side chain modifications. Vitamin D 81-90 vitamin D receptor Homo sapiens 42-45 15066918-1 2004 OBJECTIVE: Vitamin D is a potential agent for the prevention of colorectal cancer possibly through mechanisms mediated by the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 126-144 15066918-1 2004 OBJECTIVE: Vitamin D is a potential agent for the prevention of colorectal cancer possibly through mechanisms mediated by the vitamin D receptor (VDR). Vitamin D 11-20 vitamin D receptor Homo sapiens 146-149 15165715-0 2004 The role of adrenomedullin and its receptor system in cardiovascular calcification of rat induced by Vitamin D(3) plus nicotine. Vitamin D 101-110 adrenomedullin Rattus norvegicus 12-26 14966565-0 2004 Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. Vitamin D 98-107 fibroblast growth factor 23 Mus musculus 21-26 14966565-0 2004 Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. Vitamin D 98-107 fibroblast growth factor 23 Mus musculus 75-80 14966565-8 2004 These phenotypes could not be explained by currently known regulators of mineral homeostasis, indicating that FGF23 is essential for normal phosphate and vitamin D metabolism. Vitamin D 154-163 fibroblast growth factor 23 Mus musculus 110-115 15084353-9 2004 Vitamin D analogs prevented the antagonistic effect of RAL in the presence of E(2), possibly due to increased numbers of ERs. Vitamin D 0-9 RAS like proto-oncogene A Homo sapiens 55-58 15576951-4 2004 Hypercalcemia, uncontrollable hyperphosphatemia, low ALP, and low PTH might impair the vitamin D introduction. Vitamin D 87-96 ATHS Homo sapiens 53-56 15504568-8 2004 Vitamin D itself induce the formation of osteoclasts by increasing the expression of RANKL on marrow stromal cells. Vitamin D 0-9 TNF superfamily member 11 Homo sapiens 85-90 14525957-4 2004 In both vitamin D response element activation and mammalian two-hybrid assays, we found that VDR-S278V is activated by 1alpha,25(OH)2D3 but not by LCA, whereas VDR-S237M can respond to LCA but not to 1alpha,25(OH)2D3. Vitamin D 8-17 vitamin D receptor Homo sapiens 93-96 14635194-0 2003 Membrane actions of vitamin D metabolites 1alpha,25(OH)2D3 and 24R,25(OH)2D3 are retained in growth plate cartilage cells from vitamin D receptor knockout mice. Vitamin D 20-29 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 127-145 14594170-2 2003 in infants with nutritional vitamin D deficiency rickets (VDR). Vitamin D 28-37 vitamin D receptor Homo sapiens 58-61 14594170-3 2003 Our purpose was to determine the most effective dosage of vitamin D with least side effects for treating VDR. Vitamin D 58-67 vitamin D receptor Homo sapiens 105-108 14594170-10 2003 In conclusion, our findings showed that 150,000 IU or 300,000 IU of vitamin D was adequate in the treatment of VDR, but 600,000 IU of vitamin D may carry the risk of hypercalcemia. Vitamin D 68-77 vitamin D receptor Homo sapiens 111-114 12867411-1 2003 The conversion of vitamin D into an active ligand for the vitamin D receptor requires 25-hydroxylation in the liver and 1alpha-hydroxylation in the kidney. Vitamin D 18-27 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 58-76 12900504-2 2003 The long-term effect of vitamin D and dietary calcium on the expression of renal VDR was examined in the nonobese diabetic mouse. Vitamin D 24-33 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 81-84 12900504-4 2003 Vitamin D-replete mice on a 1.20% calcium diet had renal VDR levels of 165 fmol/mg protein. Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 57-60 12900504-5 2003 Calcium restriction caused renal VDR levels to decrease to <30 fmol/mg protein in vitamin D-deficient mice and to approximately 80 fmol/mg protein in vitamin D-replete mice. Vitamin D 85-94 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 33-36 12900504-6 2003 When dietary calcium was present, 50 ng of 1,25(OH)2D3 elevated the VDR levels 2- to 10-fold, depending on vitamin D status and the level of calcium. Vitamin D 107-116 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 68-71 12900504-8 2003 1,25(OH)2D3 supplementation caused relative VDR mRNA to increase 8- to 10-fold in the vitamin D-deficient mouse when dietary calcium was available. Vitamin D 86-95 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 44-47 12898515-1 2003 Abstract vitamin D receptor (VDR) and retinoid X receptor (RXR) heterodimerize to mediate the genomic actions of 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3), calcitriol), the biologically active form of vitamin D(3). Vitamin D 9-18 vitamin D receptor Homo sapiens 29-32 12898515-1 2003 Abstract vitamin D receptor (VDR) and retinoid X receptor (RXR) heterodimerize to mediate the genomic actions of 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3), calcitriol), the biologically active form of vitamin D(3). Vitamin D 9-18 retinoid X receptor alpha Homo sapiens 59-62 12716897-4 2003 We show that Ski can negatively regulate vitamin D-mediated transcription by directly interacting with the vitamin D receptor. Vitamin D 41-50 vitamin D receptor Homo sapiens 107-125 12823989-2 2003 Vitamin D controls mineral ion homeostasis and intestinal calcium absorption, which is mediated by the nuclear vitamin D receptor (VDR). Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 111-129 12823989-2 2003 Vitamin D controls mineral ion homeostasis and intestinal calcium absorption, which is mediated by the nuclear vitamin D receptor (VDR). Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 131-134 12733718-0 2003 Two key proteins of the vitamin D endocrine system come into crystal clear focus: comparison of the X-ray structures of the nuclear receptor for 1alpha,25(OH)2 vitamin D3, the plasma vitamin D binding protein, and their ligands. Vitamin D 24-33 GC vitamin D binding protein Homo sapiens 183-208 12689675-1 2003 Mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase gene (CYP27B1; 1alpha-OHase) cause pseudo vitamin D deficiency rickets (PDDR), while mutations in the vitamin D receptor (VDR) cause hereditary vitamin D resistance rickets. Vitamin D 27-36 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 158-176 12689675-1 2003 Mutations in the 25-hydroxyvitamin D-1alpha-hydroxylase gene (CYP27B1; 1alpha-OHase) cause pseudo vitamin D deficiency rickets (PDDR), while mutations in the vitamin D receptor (VDR) cause hereditary vitamin D resistance rickets. Vitamin D 27-36 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 178-181 12520531-5 2003 VDRE-BP competed in trans with the VDR-retinoid X receptor (RXR) for binding to the vitamin D response element. Vitamin D 84-93 retinoid X receptor alpha Homo sapiens 35-58 12520531-5 2003 VDRE-BP competed in trans with the VDR-retinoid X receptor (RXR) for binding to the vitamin D response element. Vitamin D 84-93 retinoid X receptor alpha Homo sapiens 60-63 12520531-6 2003 VDRE-BP-legislated resistance to 1,25-(OH)(2)D was antagonized (i.e., compensated) by another set of constitutively overexpressed proteins, the hsp-70-related intracellular vitamin D binding proteins (IDBPs). Vitamin D 173-182 heat shock protein family A (Hsp70) member 4 Homo sapiens 144-150 12520535-1 2003 Rickets and hyperparathyroidism caused by a defective Vitamin D receptor (VDR) can be prevented in humans and animals by high calcium intake, suggesting that intestinal calcium absorption is critical for 1,25(OH)(2) vitamin D [1,25-(OH)(2)D(3)] action on calcium homeostasis. Vitamin D 216-225 vitamin D receptor Homo sapiens 54-72 12520535-1 2003 Rickets and hyperparathyroidism caused by a defective Vitamin D receptor (VDR) can be prevented in humans and animals by high calcium intake, suggesting that intestinal calcium absorption is critical for 1,25(OH)(2) vitamin D [1,25-(OH)(2)D(3)] action on calcium homeostasis. Vitamin D 216-225 vitamin D receptor Homo sapiens 74-77 12520539-1 2003 Aiming at new drugs to efficiently treat diseases, in which either increased or decreased levels of active vitamin D are desirable, we have designed some 400 structurally different azole-type inhibitors and examined their capacity to selectively block vitamin D metabolism by CYP24 or synthesis by CYP27B, in human keratinocytes. Vitamin D 252-261 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 276-281 12520541-6 2003 Biosynthesis of CaBP is fully and CaT1 function is approximately 90% vitamin D-dependent. Vitamin D 69-78 transient receptor potential cation channel subfamily V member 6 Homo sapiens 34-38 12710998-2 2003 Elucidation of Vitamin D(3) receptor (VDR) regulation may reveal strategies to sensitize cancer cells to the effects of 1,25-dihydroxyvitamin D(3) and Vitamin D(3) analogs. Vitamin D 15-24 vitamin D receptor Homo sapiens 38-41 12710998-9 2003 Because resveratrol could up-regulate VDR without increasing breast cancer cell growth, we hypothesized that resveratrol mediated increase in VDR expression would sensitize breast cancer cells to the effects of 1,25-dihydroxyvitamin D(3) and Vitamin D(3) analogs. Vitamin D 242-251 vitamin D receptor Homo sapiens 142-145 12710998-10 2003 In support of this hypothesis, both T47D and MCF-7 cells pre-treated with resveratrol exhibited increased VDR mediated transactivation of a Vitamin D(3) responsive promoter compared to cells pre-treated with vehicle. Vitamin D 140-149 vitamin D receptor Homo sapiens 106-109 12710998-12 2003 These data support the concept that dietary factors, such as phytoestrogens, may impact on breast cancer cell sensitivity to Vitamin D(3) analogs through regulation of the VDR promoter. Vitamin D 125-134 vitamin D receptor Homo sapiens 172-175 12711007-1 2003 The present study was designed to explore the possible presence and location of Vitamin D response elements (VDREs) in the human insulin receptor (hIR) gene promoter. Vitamin D 80-89 potassium inwardly rectifying channel subfamily J member 4 Homo sapiens 147-150 12460926-0 2002 AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor. Vitamin D 44-53 vitamin D receptor Homo sapiens 101-122 12431109-2 2002 Mutations to the vitamin D receptor (VDR), a member of the nuclear and steroid hormone receptor family, have been linked to human vitamin D-resistant rickets (hVDRR) and result in high serum 1,25(OH)(2)D(3) concentrations and severe bone underdevelopment. Vitamin D 17-26 vitamin D receptor Homo sapiens 37-40 12413773-2 2002 We also studied the association between VDR gene polymorphisms and the response to vitamin D (VD) topical treatment in psoriatic patients. Vitamin D 83-92 vitamin D receptor Homo sapiens 40-43 12239126-3 2002 Here we provide evidence that the quantity of product 1,25-(OH)2D generated also relies on the presence and level of expression of the intracellular vitamin D binding protein-1 (IDBP-1) and its capacity to promote 24-hydroxylase (CYP24) gene expression. Vitamin D 149-158 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 230-235 12362891-6 2002 Klotho plays a critical role for the regulation of calcium and phosphorus homeostasis by negatively regulating the synthesis of active Vitamin D. Vitamin D 135-144 klotho Mus musculus 0-6 12181175-4 2002 nVDR was inversely related to the vitamin D-induced levels of CaT1 mRNA, CaBP mRNA, PMCA mRNA, and net CaTx, with the highest induction seen in BBe. Vitamin D 34-43 transient receptor potential cation channel subfamily V member 6 Homo sapiens 62-66 11983707-0 2002 The p38 and JNK pathways cooperate to trans-activate vitamin D receptor via c-Jun/AP-1 and sensitize human breast cancer cells to vitamin D(3)-induced growth inhibition. Vitamin D 53-62 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 76-81 11983707-0 2002 The p38 and JNK pathways cooperate to trans-activate vitamin D receptor via c-Jun/AP-1 and sensitize human breast cancer cells to vitamin D(3)-induced growth inhibition. Vitamin D 53-62 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 82-86 11983707-2 2002 Here we report that stress-activated protein kinases p38 and JNK trans-activate nuclear steroid vitamin D receptor (VDR) gene and increase vitamin D(3)-dependent growth inhibition in human breast cancer cells. Vitamin D 96-105 vitamin D receptor Homo sapiens 116-119 11983707-7 2002 These results establish a signaling connection between the stress MAPK pathways and steroid hormone receptor VDR expression and thereby offer new insights into regulation of cell growth by the MAPK pathways through regulation of vitamin D(3)/VDR activity. Vitamin D 229-238 vitamin D receptor Homo sapiens 109-112 11983707-7 2002 These results establish a signaling connection between the stress MAPK pathways and steroid hormone receptor VDR expression and thereby offer new insights into regulation of cell growth by the MAPK pathways through regulation of vitamin D(3)/VDR activity. Vitamin D 229-238 vitamin D receptor Homo sapiens 242-245 12174912-1 2002 BACKGROUND: The aim of this study was to analyze immunohistochemically the expression of VDR in normal and carcinomatous ovarian tissue to evaluate whether ovarian tissue may be a new potential target for biologically active vitamin D analogues. Vitamin D 225-234 vitamin D receptor Homo sapiens 89-92 12110441-11 2002 Resorption caused by IL-11 was also inhibited by both anti-mouse glycoprotein 130 (gp130) and an antibody neutralizing IL-11, but these agents had no effect on (45)Ca release caused by PTH or 1,25(OH)(2)vitamin D(3) (D(3)). Vitamin D 203-212 interleukin 11 Mus musculus 21-26 12070083-3 2002 The vitamin D(3) receptor (VDR), whose ligand 1,25-dihydroxyvitamin D(3) is the biologically active form of vitamin D(3), has been implicated in control of differentiation, cell cycle and apoptosis of mammary cells in culture, but little is known about the physiological relevance of the vitamin D(3) endocrine system in the developing gland. Vitamin D 4-13 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 27-30 12070083-3 2002 The vitamin D(3) receptor (VDR), whose ligand 1,25-dihydroxyvitamin D(3) is the biologically active form of vitamin D(3), has been implicated in control of differentiation, cell cycle and apoptosis of mammary cells in culture, but little is known about the physiological relevance of the vitamin D(3) endocrine system in the developing gland. Vitamin D 60-69 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 4-25 12070083-3 2002 The vitamin D(3) receptor (VDR), whose ligand 1,25-dihydroxyvitamin D(3) is the biologically active form of vitamin D(3), has been implicated in control of differentiation, cell cycle and apoptosis of mammary cells in culture, but little is known about the physiological relevance of the vitamin D(3) endocrine system in the developing gland. Vitamin D 60-69 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 27-30 12086963-0 2002 Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians. Vitamin D 68-77 vitamin D receptor Homo sapiens 0-18 12086963-0 2002 Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians. Vitamin D 68-77 vitamin D receptor Homo sapiens 20-23 12051678-0 2002 Biochemical and preliminary crystallographic characterization of the vitamin D sterol- and actin-binding by human vitamin D-binding protein. Vitamin D 69-78 GC vitamin D binding protein Homo sapiens 114-139 12016314-4 2002 Activation of VDR by LCA or vitamin D induced expression in vivo of CYP3A, a cytochrome P450 enzyme that detoxifies LCA in the liver and intestine. Vitamin D 28-37 vitamin D receptor Homo sapiens 14-17 11925111-6 2002 BMP7 stimulation led to a decrease of 1,25(OH)2-vitamin D3-induced binding of nuclear proteins to a vitamin D response element, as shown by electrophoretic mobility shift assay. Vitamin D 48-57 bone morphogenetic protein 7 Homo sapiens 0-4 11890700-1 2002 1,25-Dihydroxyvitamin D(3) [1,25(OH)(2) D(3)] exerts its biological effects by binding to the vitamin D receptor (VDR), which binds in turn to the vitamin D response elements located in the target gene"s promoter. Vitamin D 14-23 vitamin D receptor Homo sapiens 94-112 11890700-1 2002 1,25-Dihydroxyvitamin D(3) [1,25(OH)(2) D(3)] exerts its biological effects by binding to the vitamin D receptor (VDR), which binds in turn to the vitamin D response elements located in the target gene"s promoter. Vitamin D 14-23 vitamin D receptor Homo sapiens 114-117 11836628-6 2002 Notch-4 expression could only be detected after stimulation with Dexamethasone and Vitamin D(3). Vitamin D 83-92 notch receptor 4 Homo sapiens 0-7 11991436-4 2002 Non-genomic effects of vitamin D are rapid and mediated through a membrane-bound vitamin D receptor (VDR). Vitamin D 23-32 vitamin D receptor Homo sapiens 81-99 11991436-4 2002 Non-genomic effects of vitamin D are rapid and mediated through a membrane-bound vitamin D receptor (VDR). Vitamin D 23-32 vitamin D receptor Homo sapiens 101-104 11801653-3 2002 It has been established that the fat-soluble vitamin D(3) metabolite 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) and its nuclear receptor, the vitamin D receptor, play an important role in the immune system primarily through the transcriptional inhibition of cytokine genes that either are required for Th1 differentiation or are products of differentiated Th1 cells. Vitamin D 45-54 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 144-162 11857931-3 2002 Hereditary 1,25-dihydroxyvitamin D resistant rickets (HVDRR) known as vitamin D dependent rickets type II is a rare autosomal recessive disease that arises as a result of mutations in the gene encoding the VDR. Vitamin D 25-34 vitamin D receptor Homo sapiens 55-58 11668178-4 2002 Expression of both C/EBPbeta and C/EBPdelta increases from the growth to maturation developmental stages and, like the bone-specific osteocalcin (OC) gene, is also stimulated 3-6-fold by vitamin D(3), a regulator of osteoblast differentiation. Vitamin D 187-196 CCAAT/enhancer binding protein beta Rattus norvegicus 19-28 11382777-4 2001 A binding site, the vitamin D response element (VDRE), for a heterodimer of vitamin D receptor (VDR) and retinoic X receptor alpha (RXR alpha) within the slow MyHC3 promoter mediates chamber-specific expression of the gene. Vitamin D 20-29 retinoid X receptor alpha Gallus gallus 132-141 11489753-0 2001 Vitamin D receptor polymorphism and the risk of colorectal adenomas: evidence of interaction with dietary vitamin D and calcium. Vitamin D 106-115 vitamin D receptor Homo sapiens 0-18 11489753-1 2001 Laboratory studies and epidemiological investigations suggest that vitamin D plays a role in the etiology of colorectal adenomas, possibly through a mechanism mediated by the vitamin D receptor (VDR). Vitamin D 67-76 vitamin D receptor Homo sapiens 175-193 11489753-1 2001 Laboratory studies and epidemiological investigations suggest that vitamin D plays a role in the etiology of colorectal adenomas, possibly through a mechanism mediated by the vitamin D receptor (VDR). Vitamin D 67-76 vitamin D receptor Homo sapiens 195-198 11564619-7 2001 In multivariate linear regression models that controlled for age, education, smoking, alcohol ingestion, and vitamin D intake, the ALAD 1-1 genotype was associated with cortical bone lead levels that were 2.55 microg/g [95% confidence interval (CI) 0.05-5.05] higher than those of the variant allele carriers. Vitamin D 109-118 aminolevulinate dehydratase Homo sapiens 131-135 11467853-6 2001 RT-PCR and HPLC analysis of vitamin D metabolism in primary culture cell clones strongly suggested that the extent of endogenously produced 1alpha,25-(OH)2-D3 was inversely related to 24-OHase activity, which could thus limit the antimitotic efficacy of 1alpha,25-(OH)2-D3 particularly at late stages of colon cancer progression. Vitamin D 28-37 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 184-192 11461072-2 2001 The actions of vitamin D are mediated via the vitamin D receptor (VDR). Vitamin D 15-24 vitamin D receptor Homo sapiens 46-64 11461072-2 2001 The actions of vitamin D are mediated via the vitamin D receptor (VDR). Vitamin D 15-24 vitamin D receptor Homo sapiens 66-69 11461072-9 2001 Further investigations into the mechanisms of interactions of the VDR with other environmental and/or genetic influences to alter breast cancer risk may lead to a new understanding of the role of vitamin D in the control of cellular and developmental pathways. Vitamin D 196-205 vitamin D receptor Homo sapiens 66-69 11370854-4 2001 The first metabolite is probably a product of the vitamin D-inducible cytochrome P450, P450cc24 (CYP24), while the latter two metabolites are likely to be further metabolic products of 19-nor-1alpha,24,25-(OH)3D2. Vitamin D 50-59 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 87-95 11370854-4 2001 The first metabolite is probably a product of the vitamin D-inducible cytochrome P450, P450cc24 (CYP24), while the latter two metabolites are likely to be further metabolic products of 19-nor-1alpha,24,25-(OH)3D2. Vitamin D 50-59 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 97-102 11179725-0 2001 Three-dimensional structure-function relationship of vitamin D and vitamin D receptor model. Vitamin D 53-62 vitamin D receptor Homo sapiens 67-85 11179728-0 2001 Central role of VDR conformations for understanding selective actions of vitamin D(3) analogues. Vitamin D 73-82 vitamin D receptor Homo sapiens 16-19 11686044-10 2001 In contrast, the coexpression system with CYP24 would be applied to metabolic studies of vitamin D analogs used as drugs. Vitamin D 89-98 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 42-47 11545681-10 2001 Moreover, the increase in CaT1 mRNA expression preceded by several hours the vitamin D induction of calbindin D9K, a putative cytosolic calcium transport protein. Vitamin D 77-86 transient receptor potential cation channel subfamily V member 6 Homo sapiens 26-30 11545681-11 2001 CONCLUSION: These observations are the first to demonstrate regulation of CaT1 expression by vitamin D and are consistent with a new model of intestinal calcium absorption wherein vitamin D-mediated changes in brush border membrane CaT1 levels could be the primary gatekeeper regulating homeostatic modulation of intestinal calcium absorption efficiency. Vitamin D 93-102 transient receptor potential cation channel subfamily V member 6 Homo sapiens 74-78 11545681-11 2001 CONCLUSION: These observations are the first to demonstrate regulation of CaT1 expression by vitamin D and are consistent with a new model of intestinal calcium absorption wherein vitamin D-mediated changes in brush border membrane CaT1 levels could be the primary gatekeeper regulating homeostatic modulation of intestinal calcium absorption efficiency. Vitamin D 180-189 transient receptor potential cation channel subfamily V member 6 Homo sapiens 74-78 11545681-11 2001 CONCLUSION: These observations are the first to demonstrate regulation of CaT1 expression by vitamin D and are consistent with a new model of intestinal calcium absorption wherein vitamin D-mediated changes in brush border membrane CaT1 levels could be the primary gatekeeper regulating homeostatic modulation of intestinal calcium absorption efficiency. Vitamin D 180-189 transient receptor potential cation channel subfamily V member 6 Homo sapiens 232-236 11145567-1 2001 The vitamin D analog, (23S)-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactone (TEI-9647), is an antagonist of the 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] nuclear receptor (VDR)-mediated differentiation of human leukemia (HL-60) cells. Vitamin D 4-13 vitamin D receptor Homo sapiens 189-192 11384863-0 2001 Ligands for the vitamin D endocrine system: different shapes function as agonists and antagonists for genomic and rapid response receptors or as a ligand for the plasma vitamin D binding protein. Vitamin D 16-25 GC vitamin D binding protein Homo sapiens 169-194 11085922-1 2000 The vitamin D(3) receptor (VDR), which is the nuclear receptor for 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], acts primarily as a heterodimer with the retinoid X receptor (RXR) and binds preferentially to directly repeated arrangements of two hexameric binding sites with three spacing nucleotides [DR3-type vitamin D response elements (VDREs)]. Vitamin D 4-13 vitamin D receptor Homo sapiens 27-30 11085922-1 2000 The vitamin D(3) receptor (VDR), which is the nuclear receptor for 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], acts primarily as a heterodimer with the retinoid X receptor (RXR) and binds preferentially to directly repeated arrangements of two hexameric binding sites with three spacing nucleotides [DR3-type vitamin D response elements (VDREs)]. Vitamin D 4-13 retinoid X receptor alpha Homo sapiens 164-183 11085922-1 2000 The vitamin D(3) receptor (VDR), which is the nuclear receptor for 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], acts primarily as a heterodimer with the retinoid X receptor (RXR) and binds preferentially to directly repeated arrangements of two hexameric binding sites with three spacing nucleotides [DR3-type vitamin D response elements (VDREs)]. Vitamin D 4-13 retinoid X receptor alpha Homo sapiens 185-188 11101387-0 2000 Synthesis of vitamin D(3) and calcitriol dimers as potential chemical inducers of vitamin D receptor dimerization. Vitamin D 13-22 vitamin D receptor Homo sapiens 82-100 10948206-2 2000 Vitamin D resistance in certain primate genera is associated with the constitutive overexpression of a non-vitamin D receptor (VDR)-related, vitamin D response element-binding protein (VDRE-BP) and squelching of vitamin d-directed transactivation. Vitamin D 0-9 vitamin D receptor Homo sapiens 103-125 10948206-2 2000 Vitamin D resistance in certain primate genera is associated with the constitutive overexpression of a non-vitamin D receptor (VDR)-related, vitamin D response element-binding protein (VDRE-BP) and squelching of vitamin d-directed transactivation. Vitamin D 0-9 vitamin D receptor Homo sapiens 127-130 10948206-3 2000 We used DNA affinity chromatography to purify proteins associated with non-VDR-VDRE binding activity from vitamin d-resistant New World primate cells. Vitamin D 106-115 vitamin D receptor Homo sapiens 75-78 11050002-3 2000 Steroid hormones exert their effect through their cognate nuclear receptors, which for vitamin D metabolites is the vitamin D receptor (VDR). Vitamin D 87-96 vitamin D receptor Homo sapiens 116-134 11050002-3 2000 Steroid hormones exert their effect through their cognate nuclear receptors, which for vitamin D metabolites is the vitamin D receptor (VDR). Vitamin D 87-96 vitamin D receptor Homo sapiens 136-139 10825392-1 2000 The vitamin D receptor (VDR) is the nuclear receptor for 1, 25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] that acts as a ligand-dependent transcription factor via combined contact with coactivator proteins (steroid receptor coactivator-1, transcriptional intermediary factor 2, and receptor associated coactivator 3) and specific DNA binding sites [vitamin D response elements (VDREs)]. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 10835626-4 2000 5) mapped to one peak, and CYP24 (encoding vitamin D 24 hydroxylase), whose overexpression is likely to lead to abrogation of growth control mediated by vitamin D, mapped to the other. Vitamin D 43-52 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 27-32 10890574-2 2000 The DBP found in the emydid family of turtles is unique in that it exhibits high-affinity binding of both vitamin D and thyroxine (D/TBP). Vitamin D 106-115 TATA-box binding protein Homo sapiens 133-136 10773761-1 2000 BACKGROUND/AIMS: It is known that allelic variants of the gene encoding the vitamin-D receptor (VDR) detected by BsmI increase the risk of some advanced malignant tumors, suggesting that such variants may cause functional differences in 1,25(OH)(2) vitamin D(3). Vitamin D 249-258 vitamin D receptor Homo sapiens 76-94 10773761-1 2000 BACKGROUND/AIMS: It is known that allelic variants of the gene encoding the vitamin-D receptor (VDR) detected by BsmI increase the risk of some advanced malignant tumors, suggesting that such variants may cause functional differences in 1,25(OH)(2) vitamin D(3). Vitamin D 249-258 vitamin D receptor Homo sapiens 96-99 10751640-5 2000 Furthermore, we found that the C-3 epimerization acts as one of the important pathways in vitamin D metabolism. Vitamin D 90-99 complement C3 Rattus norvegicus 31-34 10772887-7 2000 Vitamin D analogs effectively reduce DC function via VDR-dependent pathways. Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 53-56 10797570-1 2000 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), the active metabolite of vitamin D, mediates many of its effects through the intranuclear vitamin D receptor (VDR, NR1I1), that belongs to the large superfamily of nuclear receptors. Vitamin D 19-28 vitamin D receptor Homo sapiens 146-164 10797570-1 2000 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), the active metabolite of vitamin D, mediates many of its effects through the intranuclear vitamin D receptor (VDR, NR1I1), that belongs to the large superfamily of nuclear receptors. Vitamin D 19-28 vitamin D receptor Homo sapiens 166-169 10797570-1 2000 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), the active metabolite of vitamin D, mediates many of its effects through the intranuclear vitamin D receptor (VDR, NR1I1), that belongs to the large superfamily of nuclear receptors. Vitamin D 19-28 vitamin D receptor Homo sapiens 171-176 10797570-2 2000 Vitamin D receptor can directly regulate gene expression by binding to vitamin D response elements (VDREs) located in promoter or enhancer regions of various genes. Vitamin D 71-80 vitamin D receptor Homo sapiens 0-18 10698207-2 2000 Although VDR forms stable heterodimer complex with retinoid X receptors (RXRs) on vitamin D-response elements (VDREs), it is still not clear whether VDR/RXR heterodimers are the only VDR complexes responsible for vitamin D-mediated gene transcription. Vitamin D 82-91 vitamin D receptor Homo sapiens 9-12 10698207-2 2000 Although VDR forms stable heterodimer complex with retinoid X receptors (RXRs) on vitamin D-response elements (VDREs), it is still not clear whether VDR/RXR heterodimers are the only VDR complexes responsible for vitamin D-mediated gene transcription. Vitamin D 82-91 vitamin D receptor Homo sapiens 111-114 10698207-2 2000 Although VDR forms stable heterodimer complex with retinoid X receptors (RXRs) on vitamin D-response elements (VDREs), it is still not clear whether VDR/RXR heterodimers are the only VDR complexes responsible for vitamin D-mediated gene transcription. Vitamin D 82-91 retinoid X receptor alpha Homo sapiens 73-76 10698207-2 2000 Although VDR forms stable heterodimer complex with retinoid X receptors (RXRs) on vitamin D-response elements (VDREs), it is still not clear whether VDR/RXR heterodimers are the only VDR complexes responsible for vitamin D-mediated gene transcription. Vitamin D 82-91 vitamin D receptor Homo sapiens 111-114 10698207-2 2000 Although VDR forms stable heterodimer complex with retinoid X receptors (RXRs) on vitamin D-response elements (VDREs), it is still not clear whether VDR/RXR heterodimers are the only VDR complexes responsible for vitamin D-mediated gene transcription. Vitamin D 213-222 vitamin D receptor Homo sapiens 9-12 10698207-7 2000 Our studies suggest the important role of VDR homodimers, in addition to VDR/RXR heterodimers, in vitamin D-induced transactivation. Vitamin D 98-107 vitamin D receptor Homo sapiens 42-45 10698207-7 2000 Our studies suggest the important role of VDR homodimers, in addition to VDR/RXR heterodimers, in vitamin D-induced transactivation. Vitamin D 98-107 vitamin D receptor Homo sapiens 73-76 10698207-7 2000 Our studies suggest the important role of VDR homodimers, in addition to VDR/RXR heterodimers, in vitamin D-induced transactivation. Vitamin D 98-107 retinoid X receptor alpha Homo sapiens 77-80 10646127-6 2000 These active vitamin D compounds also counteracted the effects of PTHrP at the proximal renal tubules, as reflected by a decrease in phosphate excretion. Vitamin D 13-22 parathyroid hormone-like hormone Rattus norvegicus 66-71 10653974-1 2000 We and others have previously shown that selected vitamin D analogs potentiate the vitamin D receptor (VDR) mediated transcription much more efficiently than the natural hormone itself. Vitamin D 50-59 vitamin D receptor Homo sapiens 83-101 10653974-1 2000 We and others have previously shown that selected vitamin D analogs potentiate the vitamin D receptor (VDR) mediated transcription much more efficiently than the natural hormone itself. Vitamin D 50-59 vitamin D receptor Homo sapiens 103-106 10731641-5 2000 The induction of mRNA for ckb in ROS 17/2.8 cells by E(2) or SERMS was demonstrated only after vitamin D pretreatment; there was no inhibition of E(2) induction by SERMS. Vitamin D 95-104 creatine kinase B Rattus norvegicus 26-29 10587460-1 1999 The vitamin D receptor (VDR) binds 1,25-dihydroxyvitamin D(3) and mediates its actions on gene transcription by heterodimerizing with retinoid X receptors (RXRs) on direct repeat (DR+3) vitamin D responsive elements (VDREs) located in target genes. Vitamin D 4-13 vitamin D receptor Homo sapiens 24-27 10640889-0 1999 Effect of vitamin D(3) treatment in the neonatal or adolescent age (hormonal imprinting) on the thymic glucocorticoid receptor of the adult male rat. Vitamin D 10-19 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 103-126 10640889-1 1999 Single neonatal treatment with 25 microg vitamin D(3) significantly decreased the thymic glucocorticoid receptor density (B(max)) of 6-week-old male rats. Vitamin D 41-50 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 89-112 10640889-3 1999 Single vitamin D(3) treatment (50 microg) during adolescence (i.e. 6-week-old animals) significantly increased the glucocorticoid receptor density in adult (10-week-old) males. Vitamin D 7-16 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 115-138 10523637-0 1999 Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D-responsive transcription and contribute to chromatin organization. Vitamin D 83-92 Y box binding protein 1 Rattus norvegicus 9-13 10523637-7 1999 Strikingly, mutation of the three Cbfa sites leads to abrogation of responsiveness to vitamin D. Vitamin D 86-95 Y box binding protein 1 Rattus norvegicus 34-38 10523637-9 1999 Significantly, related to these losses in transcriptional activity, mutation of the three Cbfa sites results in altered chromatin structure as reflected by loss of DNase I-hypersensitive sites at the vitamin D response element and over the proximal tissue-specific basal promoter. Vitamin D 200-209 Y box binding protein 1 Rattus norvegicus 90-94 10612418-2 1999 An active form of vitamin D, 1alpha,25(OH)2D3, serves as a vitamin D receptor (VDR)-specific ligand to activate the expression of a particular set of target genes. Vitamin D 18-27 vitamin D receptor Homo sapiens 59-77 10612418-2 1999 An active form of vitamin D, 1alpha,25(OH)2D3, serves as a vitamin D receptor (VDR)-specific ligand to activate the expression of a particular set of target genes. Vitamin D 18-27 vitamin D receptor Homo sapiens 79-82 10512735-8 1999 The truncation at the N terminus markedly impairs the ability of CYP27A to use 1alpha-hydroxyvitamin D(3) as substrate and to catalyze 25-hydroxylation in the bioactivation of vitamin D(3). Vitamin D 93-102 sterol 26-hydroxylase, mitochondrial Oryctolagus cuniculus 65-70 10516141-1 1999 Dietary restriction of phosphate is a well-known stimulator (acting indirectly via vitamin D(3)) of small intestinal apical Na-P(i) cotransport. Vitamin D 83-92 catenin, beta like 1 Mus musculus 124-128 10516141-6 1999 It is concluded that stimulation of intestinal Na-P(i) cotransport by low-P(i) diet and vitamin D(3) can be explained by an increased amount of type IIb Na-P(i) cotransporters in the brush-border membrane and that augmentation of type IIb Na-P(i) cotransporters is not related to an increased rate of transcription of the type IIb gene. Vitamin D 88-97 catenin, beta like 1 Mus musculus 47-51 10516141-6 1999 It is concluded that stimulation of intestinal Na-P(i) cotransport by low-P(i) diet and vitamin D(3) can be explained by an increased amount of type IIb Na-P(i) cotransporters in the brush-border membrane and that augmentation of type IIb Na-P(i) cotransporters is not related to an increased rate of transcription of the type IIb gene. Vitamin D 88-97 catenin, beta like 1 Mus musculus 153-157 10516141-6 1999 It is concluded that stimulation of intestinal Na-P(i) cotransport by low-P(i) diet and vitamin D(3) can be explained by an increased amount of type IIb Na-P(i) cotransporters in the brush-border membrane and that augmentation of type IIb Na-P(i) cotransporters is not related to an increased rate of transcription of the type IIb gene. Vitamin D 88-97 catenin, beta like 1 Mus musculus 153-157 10496974-6 1999 Furthermore, we observed that 1,25(OH)(2)D(3)-3-BE significantly decreased the binding of VDR to human osteocalcin vitamin D responsive element (hOCVDRE), as well as the dissociation rate of VDR from hOCVDRE, compared with 1,25(OH)(2)D(3) in COS-1 cells, transiently transfected with a VDR construct. Vitamin D 115-124 vitamin D receptor Homo sapiens 90-93 10496974-6 1999 Furthermore, we observed that 1,25(OH)(2)D(3)-3-BE significantly decreased the binding of VDR to human osteocalcin vitamin D responsive element (hOCVDRE), as well as the dissociation rate of VDR from hOCVDRE, compared with 1,25(OH)(2)D(3) in COS-1 cells, transiently transfected with a VDR construct. Vitamin D 115-124 vitamin D receptor Homo sapiens 148-151 10496974-6 1999 Furthermore, we observed that 1,25(OH)(2)D(3)-3-BE significantly decreased the binding of VDR to human osteocalcin vitamin D responsive element (hOCVDRE), as well as the dissociation rate of VDR from hOCVDRE, compared with 1,25(OH)(2)D(3) in COS-1 cells, transiently transfected with a VDR construct. Vitamin D 115-124 vitamin D receptor Homo sapiens 148-151 10485974-1 1999 Vitamin D binding protein (DBP) is a major carrier protein for the vitamin D metabolites, but may also play an important role in osteoclast differentiation. Vitamin D 67-76 GC vitamin D binding protein Homo sapiens 0-25 10499529-6 1999 However, further investigations will be needed to discuss physiologically the meaning of insulinotropic effects of vitamin D through mVDR. Vitamin D 115-124 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 133-137 10385391-1 1999 Prior studies have shown that 24,25-dihydroxyvitamin D3 [24,25-(OH)2D3] plays a major role in resting zone chondrocyte differentiation and that this vitamin D metabolite regulates both phospholipase A2 and protein kinase C (PKC) specific activities. Vitamin D 45-54 protein kinase C, alpha Rattus norvegicus 224-227 10385427-0 1999 Expression and activity of vitamin D-metabolizing cytochrome P450s (CYP1alpha and CYP24) in human nonsmall cell lung carcinomas. Vitamin D 27-36 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 82-87 10385427-8 1999 These data are consistent with the emerging hypothesis that vitamin D through its active form does not directly turn off CYP1alpha mRNA production but, rather, strongly stimulates CYP24, thereby masking CYP1alpha activity. Vitamin D 60-69 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 180-185 10406465-3 1999 We have analyzed the role of GHF-1 and of the vitamin D receptor (VDR) to confer vitamin D responsiveness to the PRL promoter. Vitamin D 46-55 vitamin D receptor Homo sapiens 66-69 10406465-8 1999 Truncation of the last 12 C-terminal amino acids of VDR, which contain the ligand-dependent activation function (AF2), abolishes regulation by vitamin D, suggesting that binding of coactivators to this region mediates ligand-dependent stimulation of the PRL promoter by the receptor. Vitamin D 143-152 vitamin D receptor Homo sapiens 52-55 10406465-9 1999 Indeed, expression of the coactivators, steroid hormone receptor coactivator-1 (SRC-1) and CREB-binding protein (CBP), significantly enhances the stimulatory effect of vitamin D mediated by the wild-type VDR but not by the AF2 mutant receptor. Vitamin D 168-177 vitamin D receptor Homo sapiens 204-207 10224118-6 1999 As a consequence, overexpression of steroid receptor coactivator-1 increased vitamin D-dependent transactivation by VDR but not by the K246A mutant. Vitamin D 77-86 vitamin D receptor Homo sapiens 116-119 10322128-0 1999 Novel nonsecosteroidal vitamin D mimics exert VDR-modulating activities with less calcium mobilization than 1,25-dihydroxyvitamin D3. Vitamin D 23-32 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 46-49 10223184-3 1999 We determined the expression, DNA binding and transactivation activity of vitamin D3 receptor (VDR) in HBL100 and a vitamin D-sensitive ZR75-1 breast cancer cell line. Vitamin D 74-83 vitamin D receptor Homo sapiens 95-98 10234571-2 1999 Several analogs were examined for their effects on DNA binding of the vitamin D receptor (VDR) homodimer complex with the murine osteopontin vitamin D response element. Vitamin D 70-79 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 90-93 10234571-11 1999 The results indicate that VDR homodimers are targets of vitamin D analogs with differential effects on C-terminal protein conformation that may partially explain the varied biological responses of these compounds. Vitamin D 56-65 vitamin D receptor Homo sapiens 26-29 10418998-1 1999 Vitamin D exerts many biological actions through nuclear vitamin D receptor (VDR)-mediated gene expression. Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 57-75 10418998-1 1999 Vitamin D exerts many biological actions through nuclear vitamin D receptor (VDR)-mediated gene expression. Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 77-80 10418998-2 1999 The transactivation function of VDR is activated by binding 1alpha,25-dihydroxyvitamin D3[1alpha,25(OH)2D3], an active form of vitamin D. Vitamin D 79-88 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 32-35 10418998-4 1999 Deficiency of vitamin D and mutations in the genes like VDR (type II genetic rickets) are known to cause rickets like lowered serum calcium, alopecia and impaired bone formation. Vitamin D 14-23 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 56-59 10418998-5 1999 However, the molecular basis of vitamin D VDR system in the vitamin D action in intact animals remained to be established. Vitamin D 32-41 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 42-45 10418998-5 1999 However, the molecular basis of vitamin D VDR system in the vitamin D action in intact animals remained to be established. Vitamin D 60-69 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 42-45 10418998-9 1999 These results demonstrated indispensability of vitamin D-VDR system in mineral and bone metabolism only in post-weaning life. Vitamin D 47-56 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 57-60 10052935-9 1999 Removal of two putative direct repeat DNA fragments in this region abolished VDR-RXR alpha-vitamin D response element complex formation. Vitamin D 91-100 vitamin D receptor Homo sapiens 77-80 10052935-9 1999 Removal of two putative direct repeat DNA fragments in this region abolished VDR-RXR alpha-vitamin D response element complex formation. Vitamin D 91-100 retinoid X receptor alpha Homo sapiens 81-90 10321413-5 1999 As with vitamin D, the biologic action of paricalcitol is mediated through activation of the vitamin D receptor (VDR). Vitamin D 8-17 vitamin D receptor Homo sapiens 93-111 9892040-1 1998 The vitamin D system is unique in that distinct calcium homeostatic functions and cell growth regulatory activities are mediated through a single ligand, calcitriol, acting through a specific receptor exhibiting ubiquitous tissue expression, the vitamin D receptor (VDR). Vitamin D 4-13 vitamin D receptor Homo sapiens 246-264 9892040-1 1998 The vitamin D system is unique in that distinct calcium homeostatic functions and cell growth regulatory activities are mediated through a single ligand, calcitriol, acting through a specific receptor exhibiting ubiquitous tissue expression, the vitamin D receptor (VDR). Vitamin D 4-13 vitamin D receptor Homo sapiens 266-269 9774468-1 1998 Vitamin D-binding protein (DBP)/Gc-globulin, the major carrier of vitamin D and its metabolites in blood, is synthesized predominantly in the liver in a developmentally regulated fashion. Vitamin D 66-75 GC vitamin D binding protein Homo sapiens 0-25 9774468-1 1998 Vitamin D-binding protein (DBP)/Gc-globulin, the major carrier of vitamin D and its metabolites in blood, is synthesized predominantly in the liver in a developmentally regulated fashion. Vitamin D 66-75 GC vitamin D binding protein Homo sapiens 32-43 9808140-1 1998 Most of the biological actions of 1,25(OH)2D3, the hormonal form of vitamin D, are mediated by the vitamin D receptor (VDR), a member of the steroid/thyroid receptor superfamily. Vitamin D 68-77 vitamin D receptor Homo sapiens 99-117 9808140-1 1998 Most of the biological actions of 1,25(OH)2D3, the hormonal form of vitamin D, are mediated by the vitamin D receptor (VDR), a member of the steroid/thyroid receptor superfamily. Vitamin D 68-77 vitamin D receptor Homo sapiens 119-122 9751523-3 1998 VDR-ablated mice and control littermates were fed a diet that has been shown to prevent secondary hyperparathyroidism in vitamin D-deficient rats. Vitamin D 121-130 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 0-3 9761785-12 1998 In contrast, a VDR genotype, which has been associated with decreased serum levels of the active hormonal form of vitamin D and increased risk for certain cancers, seemed to be related to severity of CAD (P=0.025). Vitamin D 114-123 vitamin D receptor Homo sapiens 15-18 9751364-1 1998 PURPOSE: Reports in the osteoporosis literature demonstrating the increased activity of specific alleles of the vitamin D receptor and epidemiological data linking vitamin D levels with prostate cancer have stimulated research into possible associations between vitamin D receptor genotype and the development of prostate cancer. Vitamin D 112-121 vitamin D receptor Homo sapiens 262-280 10101442-10 1998 Results from this study suggest that faster bone mineral loss and more exaggerated disturbances of vitamin D metabolism are present in haemodialyzed uraemic patients with BB than bb genotype of VDR. Vitamin D 99-108 vitamin D receptor Homo sapiens 194-197 9584330-6 1998 Since only the vitamin D compounds which possess hydroxyl groups both in the position 1 alpha and in the side chain, bind to the vitamin D receptor, we suggest that a local metabolism of MC 1582 and 1 alpha(OH)D3 takes place in the skin to the active, side-chain-hydroxylated species, probably to KH 1060 and 1 alpha,25(OH)2D3. Vitamin D 15-24 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 129-147 9586948-1 1998 The biological active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), mediates most of its actions through the intracellular vitamin D receptor (VDR). Vitamin D 30-39 vitamin D receptor Homo sapiens 136-154 9586948-1 1998 The biological active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), mediates most of its actions through the intracellular vitamin D receptor (VDR). Vitamin D 30-39 vitamin D receptor Homo sapiens 156-159 9586948-2 1998 VDR binds to vitamin D responsive elements (VDREs) in the promoter region of responsive genes and regulates transcription. Vitamin D 13-22 vitamin D receptor Homo sapiens 0-3 9528006-1 1998 The vitamin D receptor (VDR) binds to specific DNA sequences termed vitamin D response elements (VDREs) thereby enhancing or repressing transcription. Vitamin D 4-13 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 24-27 9597143-8 1998 The active form of vitamin D has immunomodulatory effects, and allelic variants of the vitamin D receptor appear to be associated with differential susceptibility to several infectious diseases. Vitamin D 19-28 vitamin D receptor Homo sapiens 87-105 9368060-0 1997 Identification of a novel suppressive vitamin D response sequence in the 5"-flanking region of the murine Id1 gene. Vitamin D 38-47 inhibitor of DNA binding 1, HLH protein Mus musculus 106-109 9368060-9 1997 These results indicate the involvement of the novel 57-bp sequence in the vitamin D suppression of Id1 gene transcription. Vitamin D 74-83 inhibitor of DNA binding 1, HLH protein Mus musculus 99-102 9431991-5 1997 However, only those metabolites which were able to transactivate a classical vitamin D response element had the ability to repress IL-8 promoter activation, suggesting that this repression is mediated via vitamin D receptor (VDR). Vitamin D 77-86 vitamin D receptor Homo sapiens 205-223 9431991-5 1997 However, only those metabolites which were able to transactivate a classical vitamin D response element had the ability to repress IL-8 promoter activation, suggesting that this repression is mediated via vitamin D receptor (VDR). Vitamin D 77-86 vitamin D receptor Homo sapiens 225-228 9344589-0 1997 Stable transfection of U937 cells with sense or antisense RXR-alpha cDNA suggests a role for RXR-alpha in the control of monoblastic differentiation induced by retinoic acid and vitamin D. Vitamin D 178-187 retinoid X receptor alpha Homo sapiens 58-67 9344589-0 1997 Stable transfection of U937 cells with sense or antisense RXR-alpha cDNA suggests a role for RXR-alpha in the control of monoblastic differentiation induced by retinoic acid and vitamin D. Vitamin D 178-187 retinoid X receptor alpha Homo sapiens 93-102 9337080-3 1997 As an additional index of leukaemic cell differentiation, induction of expression of the phenotypic cell surface antigen, CD14, and the beta2-integrins, CD11b and CD18 by the vitamin D and retinoid compounds were monitored using fluorescence activated cell sorting (FACS) analyses. Vitamin D 175-184 integrin subunit alpha M Homo sapiens 153-158 27405232-9 1997 However, in HL-60 cells the vitamin D derivatives were capable of preventing the further down-regulation of RXR in the presence of the retinoid. Vitamin D 28-37 retinoid X receptor alpha Homo sapiens 108-111 9117516-8 1997 Induction of the receptor for the anti-inflammatory cytokine IL-10 may be involved in the antipsoriatic action of vitamin D derivatives. Vitamin D 114-123 interleukin 10 receptor subunit alpha Homo sapiens 61-66 9010343-1 1996 The nature of the DNA binding interactions of the human vitamin D receptor (hVDR) with the murine osteopontin vitamin D response element (mOP VDRE) was examined. Vitamin D 56-65 vitamin D receptor Homo sapiens 76-80 9010343-12 1996 From these results we infer that homodimers of the hVDR which respond with enhanced DNA binding to particular vitamin D response elements when exposed to 1,25-(OH)2D3 are possible. Vitamin D 110-119 vitamin D receptor Homo sapiens 51-55 8678897-2 1996 One such analog is the vitamin D2 metabolite, 1 alpha,24(S)-dihydroxyvitamin D2, which binds strongly to the vitamin D receptor and induces vitamin D-dependent gene expression in vitro. Vitamin D 23-32 vitamin D receptor Homo sapiens 109-127 8709103-1 1996 Two proteins play important roles in the expression of vitamin D function: the specific nuclear receptor protein (vitamin D receptor, VDR) and the transport protein (vitamin D binding protein, DBP). Vitamin D 55-64 vitamin D receptor Homo sapiens 114-132 8709103-1 1996 Two proteins play important roles in the expression of vitamin D function: the specific nuclear receptor protein (vitamin D receptor, VDR) and the transport protein (vitamin D binding protein, DBP). Vitamin D 55-64 vitamin D receptor Homo sapiens 134-137 8709103-1 1996 Two proteins play important roles in the expression of vitamin D function: the specific nuclear receptor protein (vitamin D receptor, VDR) and the transport protein (vitamin D binding protein, DBP). Vitamin D 55-64 GC vitamin D binding protein Homo sapiens 166-191 8807778-2 1996 Vitamin D-induced inhibition of IFN-gamma production was most pronounced in MNL cultures supplemented with 1,25(OH)2D3 at 1.0 nM or more, a concentration equal to or exceeding that in plasma of cows with clinical hypocalcemia. Vitamin D 0-9 interferon gamma Bos taurus 32-41 8660573-1 1996 Serum vitamin D binding protein (DBP, also known as Gc-globulin) is a multifunctional protein capable of binding both vitamin D metabolites and actin. Vitamin D 6-15 GC vitamin D binding protein Homo sapiens 52-63 8734984-2 1996 The aim of the present study was to test whether the vitamin D-dependent Ca(2+)-binding protein calbindin-D9k could function as an important cytosolic Ca2+ buffer in duodenal enterocytes while facilitating transepithelial active transport of Ca2+ ions. Vitamin D 53-62 S100 calcium binding protein G Sus scrofa 96-109 8622969-4 1996 Replacement of Ser-208 with glycine or alanine indicates that phosphorylation of hVDR at Ser-208 is not obligatory for 1,25(OH)2D3 action, but coexpression of wild-type hVDR and CK-11 elicits a dose-dependent enhancement of 1,25(OH)2D3-stimulated transcription of a vitamin D responsive element reporter construct. Vitamin D 266-275 vitamin D receptor Homo sapiens 81-85 8651937-9 1996 In gel shift assays, the binding of vitamin D receptor to the composite AP-1 plus vitamin-D responsive promoter region of the human osteocalcin gene after EB 1089 treatment was stronger and longer-lasting than after calcitriol treatment. Vitamin D 82-91 vitamin D receptor Homo sapiens 36-54 8726384-1 1996 The effects of the active metabolite of vitamin D, 1,25 dihydroxyvitamin D3 (1,25D), are mediated via the vitamin D receptor (VDR). Vitamin D 40-49 vitamin D receptor Homo sapiens 106-124 8726384-1 1996 The effects of the active metabolite of vitamin D, 1,25 dihydroxyvitamin D3 (1,25D), are mediated via the vitamin D receptor (VDR). Vitamin D 40-49 vitamin D receptor Homo sapiens 126-129 9156521-1 1996 The receptor for the active metabolite of vitamin D, 1,25(OH)(2)D(3), known as the vitamin D receptor (VDR), belongs to the steroid hormone nuclear receptor superfamily. Vitamin D 42-51 vitamin D receptor Homo sapiens 83-101 9156521-1 1996 The receptor for the active metabolite of vitamin D, 1,25(OH)(2)D(3), known as the vitamin D receptor (VDR), belongs to the steroid hormone nuclear receptor superfamily. Vitamin D 42-51 vitamin D receptor Homo sapiens 103-106 9627686-7 1996 Because RXR heterodimerizes with either RARs or VDR, it functions as a key protein in the overall retinoid or vitamin D response of a given biological system. Vitamin D 110-119 retinoid X receptor alpha Homo sapiens 8-11 9627686-7 1996 Because RXR heterodimerizes with either RARs or VDR, it functions as a key protein in the overall retinoid or vitamin D response of a given biological system. Vitamin D 110-119 vitamin D receptor Homo sapiens 48-51 9627691-0 1996 The anti-proliferative and differentiation-inducing effects of vitamin D analogs are not determined by the binding affinity for the vitamin D receptor alone. Vitamin D 63-72 vitamin D receptor Homo sapiens 132-150 8657749-3 1996 When Ho-0, an elution with n-hexane, and Ho-1 were administrated to the rachitic rats fed with a vitamin D-free, low-phosphorus diet, they not only increased significantly the concentration of inorganic phosphorus in serum, but also significantly promoted bone calcification. Vitamin D 97-106 heme oxygenase 1 Rattus norvegicus 41-45 21597875-3 1995 The affinity of vitamin D analogs for vitamin D receptor relative to 125(OH)(2)-vitamin D-3 was determined with a hydroxyapatite-based competitive binding assay. Vitamin D 16-25 vitamin D receptor Homo sapiens 38-56 21597875-6 1995 Competitive binding of the vitamin D analogs to vitamin D receptor ranged from 51% to 72% that of 1,25(OH)(2)-vitamin D-3, suggesting a receptor-mediated response. Vitamin D 27-36 vitamin D receptor Homo sapiens 48-66 7575575-3 1995 The T-box mutant hVDR displayed attenuated vitamin D responsive element (VDRE) binding in the presence of RXR and was severely compromised in transcriptional activation. Vitamin D 43-52 vitamin D receptor Homo sapiens 17-21 7575575-3 1995 The T-box mutant hVDR displayed attenuated vitamin D responsive element (VDRE) binding in the presence of RXR and was severely compromised in transcriptional activation. Vitamin D 43-52 retinoid X receptor alpha Homo sapiens 106-109 8577633-2 1995 The effects of the biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25 (OH)2D3), are mediated by binding to a specific intracellular vitamin D receptor, which is present in most tissues including the skin where it regulates the growth of epidermal cells. Vitamin D 47-56 vitamin D receptor Homo sapiens 151-169 7558419-5 1995 Although the antiproliferative effect of the vitamin-D sterols requires high-affinity binding to the cytoplasmic vitamin-D receptor (VDR), vitamin-D sterols have no effect on VDR mRNA levels in Caco-2 cells. Vitamin D 45-54 vitamin D receptor Homo sapiens 113-131 7558419-5 1995 Although the antiproliferative effect of the vitamin-D sterols requires high-affinity binding to the cytoplasmic vitamin-D receptor (VDR), vitamin-D sterols have no effect on VDR mRNA levels in Caco-2 cells. Vitamin D 113-122 vitamin D receptor Homo sapiens 133-136 7558419-7 1995 This suggests that VDR mRNA abundance could nevertheless be important for vitamin-D-related c-myc-independent growth control in Caco-2 cells. Vitamin D 74-83 vitamin D receptor Homo sapiens 19-22 7649081-11 1995 Normalization of PTH/PTHrp receptor mRNA expression was observed after vitamin D supplementation (D-D+ rats), but not after correction of the hypocalcemia and secondary hyperparathyroidism by oral lactose and calcium supplementation. Vitamin D 71-80 parathyroid hormone-like hormone Rattus norvegicus 21-26 7649081-12 1995 In the epi/metaphysis, an approximately 2-fold increase in PTH/PTHrp receptor mRNA was also observed in the D-D- rats compared to the controls; this increase was partially corrected upon normalization of the calcemia and PTH levels with either vitamin D (D-D+ group) or lactose/calcium (D-Ca+ group). Vitamin D 244-253 parathyroid hormone-like hormone Rattus norvegicus 63-68 21153172-0 1995 Pharmacokinetic studies of vitamin D analogues: relationship to vitamin D binding protein (DBP). Vitamin D 27-36 D-box binding PAR bZIP transcription factor Rattus norvegicus 91-94 21153172-2 1995 During the development of synthetic vitamin D analogues, it has been shown that the majority of analogues bind to DBP with a low affinity. Vitamin D 36-45 D-box binding PAR bZIP transcription factor Rattus norvegicus 114-117 21153172-8 1995 In the group of vitamin D analogues which showed a low or no affinity for DBP, we have identified compounds with a short t(1/2) and compounds with a long t(1/2), all characterized by low initial serum levels. Vitamin D 16-25 D-box binding PAR bZIP transcription factor Rattus norvegicus 74-77 21153172-10 1995 These results showed that the initial serum level of vitamin D analogues correlated with the affinity for DBP, but that there seemed to be no correlation with the metabolic rate as reflected by measurement of the serum half-life of the analogues. Vitamin D 53-62 D-box binding PAR bZIP transcription factor Rattus norvegicus 106-109 7606167-1 1995 During the course of our studies to probe the vitamin D ligand-binding domains of vitamin D-binding protein and vitamin D receptor, we developed a synthetic procedure to modify the 3 beta-hydroxyl group of vitamin D3 and its 25-hydroxy- and 1,25-dihydroxy metabolites with a 3"-aminopropylether group. Vitamin D 46-55 GC vitamin D binding protein Homo sapiens 82-107 7878015-1 1995 The active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], regulates gene transcription through binding to the vitamin D receptor (VDR), a member of the nuclear hormone receptor superfamily. Vitamin D 25-34 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 128-146 7878015-1 1995 The active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], regulates gene transcription through binding to the vitamin D receptor (VDR), a member of the nuclear hormone receptor superfamily. Vitamin D 25-34 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 148-151 7626415-1 1995 The basic features on the vitamin D endocrine system, synthesis of the main metabolite 1,25-dihydroxyvitamin D3 (1,25) and its genomic action mediated via the vitamin D receptor (VDR), are reviewed. Vitamin D 26-35 vitamin D receptor Homo sapiens 159-177 7626415-1 1995 The basic features on the vitamin D endocrine system, synthesis of the main metabolite 1,25-dihydroxyvitamin D3 (1,25) and its genomic action mediated via the vitamin D receptor (VDR), are reviewed. Vitamin D 26-35 vitamin D receptor Homo sapiens 179-182 7626415-4 1995 Then, the basis of the systemic theory of vitamin D action on teeth (clinical and experimental data and the dissimilar distribution of VDR and of potential vitamin D-dependent proteins in dental cells) are exposed. Vitamin D 42-51 vitamin D receptor Homo sapiens 135-138 8076631-1 1994 The binding of transcription factor AP-1 and vitamin D receptor (VDR) to the composite AP-1 plus vitamin-D-responsive promoter region (AP-1 + VDRE) of the human osteocalcin gene was characterized in osteocalcin-producing (MG-63) and non-producing (U2-Os, SaOs-2) human osteosarcoma cell lines. Vitamin D 97-106 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 36-40 8076631-1 1994 The binding of transcription factor AP-1 and vitamin D receptor (VDR) to the composite AP-1 plus vitamin-D-responsive promoter region (AP-1 + VDRE) of the human osteocalcin gene was characterized in osteocalcin-producing (MG-63) and non-producing (U2-Os, SaOs-2) human osteosarcoma cell lines. Vitamin D 97-106 vitamin D receptor Homo sapiens 45-63 8076631-1 1994 The binding of transcription factor AP-1 and vitamin D receptor (VDR) to the composite AP-1 plus vitamin-D-responsive promoter region (AP-1 + VDRE) of the human osteocalcin gene was characterized in osteocalcin-producing (MG-63) and non-producing (U2-Os, SaOs-2) human osteosarcoma cell lines. Vitamin D 97-106 vitamin D receptor Homo sapiens 65-68 8034312-1 1994 The recently described retinoid X receptors (RXRs) respond to the novel retinoid 9-cis-retinoic acid and also serve as heterodimeric partners for the vitamin D, thyroid hormone, and retinoic acid receptors (VDR, TR, and RAR, respectively). Vitamin D 150-159 vitamin D receptor Homo sapiens 207-210 8227160-2 1993 Since some of the direct membrane effects of vitamin D metabolites are nongenomic, we hypothesized that protein kinase C (PKC) plays a role in signal transduction for these chondrocyte differentiation factors and that the regulation of PKC by the vitamin D metabolites is cell maturation dependent. Vitamin D 45-54 protein kinase C, gamma Rattus norvegicus 104-120 8227160-2 1993 Since some of the direct membrane effects of vitamin D metabolites are nongenomic, we hypothesized that protein kinase C (PKC) plays a role in signal transduction for these chondrocyte differentiation factors and that the regulation of PKC by the vitamin D metabolites is cell maturation dependent. Vitamin D 45-54 protein kinase C, gamma Rattus norvegicus 122-125 8227160-2 1993 Since some of the direct membrane effects of vitamin D metabolites are nongenomic, we hypothesized that protein kinase C (PKC) plays a role in signal transduction for these chondrocyte differentiation factors and that the regulation of PKC by the vitamin D metabolites is cell maturation dependent. Vitamin D 247-256 protein kinase C, gamma Rattus norvegicus 104-120 8227160-2 1993 Since some of the direct membrane effects of vitamin D metabolites are nongenomic, we hypothesized that protein kinase C (PKC) plays a role in signal transduction for these chondrocyte differentiation factors and that the regulation of PKC by the vitamin D metabolites is cell maturation dependent. Vitamin D 247-256 protein kinase C, gamma Rattus norvegicus 122-125 8227160-2 1993 Since some of the direct membrane effects of vitamin D metabolites are nongenomic, we hypothesized that protein kinase C (PKC) plays a role in signal transduction for these chondrocyte differentiation factors and that the regulation of PKC by the vitamin D metabolites is cell maturation dependent. Vitamin D 247-256 protein kinase C, gamma Rattus norvegicus 236-239 8227160-11 1993 The results of this study indicate that vitamin D metabolites stimulate PKC activity in a metabolite- and cell-maturation-specific manner. Vitamin D 40-49 protein kinase C, gamma Rattus norvegicus 72-75 8218210-10 1993 The presence of multiple GR binding sites in the rat OC gene proximal promoter indicates that regulation of basal and vitamin D-enhanced transcription by glucocorticoids may involve the integrated activities of multiple, independent GREs. Vitamin D 118-127 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 25-27 8274878-1 1993 We tested whether the protein kinase C (PKC) modulation of PTH-sensitive adenylate cyclase in ROS 17/2.8 cells is affected by the glucocorticoid dexamethasone and the vitamin D hormone 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. Vitamin D 167-176 protein kinase C, gamma Rattus norvegicus 22-38 8274878-1 1993 We tested whether the protein kinase C (PKC) modulation of PTH-sensitive adenylate cyclase in ROS 17/2.8 cells is affected by the glucocorticoid dexamethasone and the vitamin D hormone 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. Vitamin D 167-176 protein kinase C, gamma Rattus norvegicus 40-43 8482081-0 1993 Detection of the 9-kDa vitamin D-dependent calbindin gene in a fruit bat (Rousettus aegyptiacus) fibroblast cell line. Vitamin D 23-32 calbindin 1 Mus musculus 43-52 8382345-3 1993 We have identified two classes of vitamin D response elements that are activated either by the vitamin D receptor (VDR) alone or by heterodimers of VDR and the retinoid-X receptor-alpha (RXR-alpha). Vitamin D 34-43 vitamin D receptor Homo sapiens 95-113 8382345-3 1993 We have identified two classes of vitamin D response elements that are activated either by the vitamin D receptor (VDR) alone or by heterodimers of VDR and the retinoid-X receptor-alpha (RXR-alpha). Vitamin D 34-43 vitamin D receptor Homo sapiens 115-118 8382345-3 1993 We have identified two classes of vitamin D response elements that are activated either by the vitamin D receptor (VDR) alone or by heterodimers of VDR and the retinoid-X receptor-alpha (RXR-alpha). Vitamin D 34-43 vitamin D receptor Homo sapiens 148-151 8382345-3 1993 We have identified two classes of vitamin D response elements that are activated either by the vitamin D receptor (VDR) alone or by heterodimers of VDR and the retinoid-X receptor-alpha (RXR-alpha). Vitamin D 34-43 retinoid X receptor alpha Homo sapiens 160-185 8382345-3 1993 We have identified two classes of vitamin D response elements that are activated either by the vitamin D receptor (VDR) alone or by heterodimers of VDR and the retinoid-X receptor-alpha (RXR-alpha). Vitamin D 34-43 retinoid X receptor alpha Homo sapiens 187-196 8382345-4 1993 The motif GGGTGA arranged as a direct repeat with a spacing of six nucleotides or as a palindrome without spacing, or as an inverted palindrome with a 12-nucleotide spacing, confers vitamin D inducibility mediated by VDR alone. Vitamin D 182-191 vitamin D receptor Homo sapiens 217-220 8381969-9 1993 Such protein-DNA interactions at the VDRE are consistent with repression of competency for vitamin D-mediated transcriptional enhancement in proliferating osteoblasts expressing high levels of Fos and Jun. Vitamin D 91-100 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 193-196 1544902-4 1992 Binding of human progesterone receptor to the PRE was also enhanced in the presence of the antiprogestin, RU486, but very little effect was observed in the presence of estradiol, dexamethasone, testosterone, and vitamin D. Vitamin D 212-221 progesterone receptor Gallus gallus 17-38 1581109-2 1992 Previous studies, demonstrating a correlation between 1,25-(OH)2D3-dependent alkaline phosphatase and phospholipase A2 activities in matrix vesicles isolated from growth cartilage chondrocyte cultures, suggest that one mechanism of vitamin D action may be via autocrine or paracrine action of PGE2. Vitamin D 232-241 phospholipase A2, group IB, pancreas Mus musculus 102-118 1543898-7 1992 Other nuclear factors such as fos and jun can influence vitamin D-mediated gene expression. Vitamin D 56-65 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 30-33 1303095-1 1992 The vitamin-D-binding protein (DBP), also called group-specific component, is well known for two main reasons: its genetic polymorphism, and its binding affinities for actin and vitamin D compounds. Vitamin D 178-187 GC vitamin D binding protein Homo sapiens 4-29 1303095-1 1992 The vitamin-D-binding protein (DBP), also called group-specific component, is well known for two main reasons: its genetic polymorphism, and its binding affinities for actin and vitamin D compounds. Vitamin D 178-187 GC vitamin D binding protein Homo sapiens 31-34 1303095-3 1992 The molecular genetic data for DBP are analyzed in order to show that the affinities for vitamin D are supported by the genetic variability. Vitamin D 89-98 GC vitamin D binding protein Homo sapiens 31-34 1868452-0 1991 K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors: effects of supplemental dietary calcium and vitamin D deficiency. Vitamin D 109-118 KRAS proto-oncogene, GTPase Rattus norvegicus 0-5 1868452-8 1991 These findings suggest that alterations in K-ras mutations may be one possible mechanism by which calcium and vitamin D status influence colonic carcinogenesis in this experimental model. Vitamin D 110-119 KRAS proto-oncogene, GTPase Rattus norvegicus 43-48 1655638-1 1991 C57Bl/6 female mice fed a Vitamin D (VIT-D)-deficient diet had serum levels of 25-hydroxyvitamin D decreasing with the time of diet exposure (3 and 8 weeks). Vitamin D 26-35 vitrin Mus musculus 37-40 1757478-3 1991 We systematically evaluated MGP mRNA expression as a function of bone and cartilage development and also as regulated by vitamin D during growth and cellular differentiation. Vitamin D 121-130 matrix Gla protein Rattus norvegicus 28-31 1757478-12 1991 Interestingly, when MGP mRNA transcripts from vitamin D treated and untreated chondrocytes and osteoblasts were analyzed by high resolution Northern blot analysis, we observed two distinct species of MGP mRNA in the vitamin D treated chondrocyte cultures while all other cultures examined exhibited only a single MGP mRNA transcript. Vitamin D 46-55 matrix Gla protein Rattus norvegicus 20-23 1757478-12 1991 Interestingly, when MGP mRNA transcripts from vitamin D treated and untreated chondrocytes and osteoblasts were analyzed by high resolution Northern blot analysis, we observed two distinct species of MGP mRNA in the vitamin D treated chondrocyte cultures while all other cultures examined exhibited only a single MGP mRNA transcript. Vitamin D 216-225 matrix Gla protein Rattus norvegicus 200-203 1757478-12 1991 Interestingly, when MGP mRNA transcripts from vitamin D treated and untreated chondrocytes and osteoblasts were analyzed by high resolution Northern blot analysis, we observed two distinct species of MGP mRNA in the vitamin D treated chondrocyte cultures while all other cultures examined exhibited only a single MGP mRNA transcript. Vitamin D 216-225 matrix Gla protein Rattus norvegicus 200-203 1757478-13 1991 Primer extension analysis indicated a single transcription start site in both osteoblasts and chondrocytes with or without vitamin D treatment, suggesting that the lower molecular weight MGP message in vitamin D treated chondrocytes may be related to a modification in post-transcriptional processing. Vitamin D 123-132 matrix Gla protein Rattus norvegicus 187-190 1757478-13 1991 Primer extension analysis indicated a single transcription start site in both osteoblasts and chondrocytes with or without vitamin D treatment, suggesting that the lower molecular weight MGP message in vitamin D treated chondrocytes may be related to a modification in post-transcriptional processing. Vitamin D 202-211 matrix Gla protein Rattus norvegicus 187-190 2036965-1 1991 The mouse kidney is a unique tissue since both vitamin D-dependent calcium binding proteins (calbindin-D9k and calbindin-D28k) are present in the same cells of the distal convoluted tubule. Vitamin D 47-56 calbindin 1 Mus musculus 111-125 2036965-5 1991 The peak of induction of renal calbindin-D28k mRNA was at 12 h after a single injection of 1,25(OH)2D3 (200 ng/100 g body wt) to vitamin D-deficient mice, and a decrease was observed at 24 h (similar to the time course of response of other steroid-regulated genes). Vitamin D 129-138 calbindin 1 Mus musculus 31-45 2171704-3 1990 Since most of the actions of vitamin D are mediated by its receptors (VDR), abnormalities of VDR have been postulated in XLH. Vitamin D 29-38 vitamin D receptor Homo sapiens 70-73 2171704-3 1990 Since most of the actions of vitamin D are mediated by its receptors (VDR), abnormalities of VDR have been postulated in XLH. Vitamin D 29-38 vitamin D receptor Homo sapiens 93-96 2171704-9 1990 These results indicate that a decreased concentration of VDR secondary to persistent hypophosphatemia is one of the causes of vitamin D resistance in XLH. Vitamin D 126-135 vitamin D receptor Homo sapiens 57-60 2224592-1 1990 Vitamin D and its metabolites are tightly bound to the serum vitamin D-binding protein (DBP) and only the free hormone is considered to be physiologically active. Vitamin D 0-9 D-box binding PAR bZIP transcription factor Rattus norvegicus 88-91 1696927-1 1990 The group-specific component (GC), also known as the vitamin D-binding protein, transports vitamin D and its metabolites in plasma to target tissues throughout the body. Vitamin D 53-62 vitamin D binding protein Mus musculus 4-33 2177015-3 1990 Intestinal calbindin and its mRNA were almost absent in vitamin D-deficient chicks and were not affected by dietary alteration. Vitamin D 56-65 calbindin 1 Gallus gallus 11-20 2177015-4 1990 Renal calbindin and its mRNA were lower in the vitamin D-deficient than in vitamin D3- or 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)-fed chicks. Vitamin D 47-56 calbindin 1 Gallus gallus 6-15 2177015-9 1990 The results suggest that: (a) most of the changes in renal and intestinal calbindin could be attributed to the changes in the mRNA; (b) the adaptation to dietary Ca and P alterations requires vitamin D metabolites; (c) high dietary Ca affects intestinal and renal calbindin-mRNA and calbindin via mechanisms independent of kidney 1-hydroxylase; and (d) plasma Ca and renal calbindin or its mRNA tend to change together in vitamin D-deficient or vitamin D3-fed, but not in 1,25(OH)2D3-fed chicks. Vitamin D 192-201 calbindin 1 Gallus gallus 74-83 2177015-9 1990 The results suggest that: (a) most of the changes in renal and intestinal calbindin could be attributed to the changes in the mRNA; (b) the adaptation to dietary Ca and P alterations requires vitamin D metabolites; (c) high dietary Ca affects intestinal and renal calbindin-mRNA and calbindin via mechanisms independent of kidney 1-hydroxylase; and (d) plasma Ca and renal calbindin or its mRNA tend to change together in vitamin D-deficient or vitamin D3-fed, but not in 1,25(OH)2D3-fed chicks. Vitamin D 422-431 calbindin 1 Gallus gallus 74-83 33798678-2 2021 Transcriptional regulation of REN has been linked to enhancer-promoter crosstalk, cAMP response element-binding protein (CREB), the active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), and a less well-characterized intronic silencer element. Vitamin D 153-162 cAMP responsive element binding protein 1 Homo sapiens 82-119 33798678-2 2021 Transcriptional regulation of REN has been linked to enhancer-promoter crosstalk, cAMP response element-binding protein (CREB), the active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), and a less well-characterized intronic silencer element. Vitamin D 153-162 cAMP responsive element binding protein 1 Homo sapiens 121-125 33771629-0 2021 PARACOCCIDIOIDES brasiliensis induces IL-32 and is controlled by IL-15/IL-32/vitamin D pathway in vitro. Vitamin D 77-86 interleukin 15 Homo sapiens 65-70 33819635-0 2021 Authors" reply: Vitamin D sufficiency and COVID-19: is vitamin D binding protein (and its polymorphism) the missing link? Vitamin D 16-25 GC vitamin D binding protein Homo sapiens 55-80 33772215-0 2021 The effect of vitamin D on fibroblast growth factor 23: a systematic review and meta-analysis of randomized controlled trials. Vitamin D 14-23 fibroblast growth factor 23 Homo sapiens 27-54 33815294-9 2021 In children with severe or refractory symptoms, FGF23 inhibition using burosumab may provide superior outcomes compared to conventional medical therapy with phosphate supplements and active vitamin D analogues. Vitamin D 190-199 fibroblast growth factor 23 Homo sapiens 48-53 24943330-5 2014 RESULTS: Neonatal mice that had in utero and early-life vitamin D deficiency had significantly increased pulmonary CD3(+) CD4(+) T1ST2(+) cells and reduced CD4(+) IL-10(+) cells. Vitamin D 56-65 interleukin 1 receptor-like 1 Mus musculus 129-134 12694466-3 2003 Vitamin D acts via vitamin D receptor (VDR), and an association of genetic polymorphisms of the VDR gene has been reported. Vitamin D 0-9 vitamin D receptor Homo sapiens 19-37 12694466-3 2003 Vitamin D acts via vitamin D receptor (VDR), and an association of genetic polymorphisms of the VDR gene has been reported. Vitamin D 0-9 vitamin D receptor Homo sapiens 39-42 12694466-3 2003 Vitamin D acts via vitamin D receptor (VDR), and an association of genetic polymorphisms of the VDR gene has been reported. Vitamin D 0-9 vitamin D receptor Homo sapiens 96-99 34655755-2 2022 Vitamin D can affect the differentiation, maturation, and activation of dendritic cells (DCs) and regulate autophagy via vitamin D receptor signaling. Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 121-139 34779254-0 2022 Vitamin D supplementation induces CatG-mediated CD4+ T cell inactivation and restores pancreatic beta-cell function in mice with type 1 diabetes. Vitamin D 0-9 CD4 antigen Mus musculus 48-51 34727512-8 2022 Following vitamin D therapy there were 148 (77.9%) VDR and 42 (22.1%) VDNR. Vitamin D 10-19 vitamin D receptor Homo sapiens 51-54 34852423-9 2021 SNPs, such as rs11723621 and rs7041, in the group-specific component gene (GC) and rs11023332 in the phosphodiesterase 3B (PDE3B) gene were significantly associated with vitamin D deficiency in both meta- and mega-analyses. Vitamin D 170-179 phosphodiesterase 3B Homo sapiens 101-121 34852423-9 2021 SNPs, such as rs11723621 and rs7041, in the group-specific component gene (GC) and rs11023332 in the phosphodiesterase 3B (PDE3B) gene were significantly associated with vitamin D deficiency in both meta- and mega-analyses. Vitamin D 170-179 phosphodiesterase 3B Homo sapiens 123-128 34852423-11 2021 eQTL analysis for rs12803256 for the genes related to vitamin D metabolism, including glutamine-dependent NAD(+) synthetase (NADSYN1) and 7-dehydrocholesterol reductase (DHCR7), showed significantly different expression according to alleles. Vitamin D 54-63 NAD synthetase 1 Homo sapiens 86-123 34852423-11 2021 eQTL analysis for rs12803256 for the genes related to vitamin D metabolism, including glutamine-dependent NAD(+) synthetase (NADSYN1) and 7-dehydrocholesterol reductase (DHCR7), showed significantly different expression according to alleles. Vitamin D 54-63 NAD synthetase 1 Homo sapiens 125-132 34852423-11 2021 eQTL analysis for rs12803256 for the genes related to vitamin D metabolism, including glutamine-dependent NAD(+) synthetase (NADSYN1) and 7-dehydrocholesterol reductase (DHCR7), showed significantly different expression according to alleles. Vitamin D 54-63 7-dehydrocholesterol reductase Homo sapiens 138-168 34852423-11 2021 eQTL analysis for rs12803256 for the genes related to vitamin D metabolism, including glutamine-dependent NAD(+) synthetase (NADSYN1) and 7-dehydrocholesterol reductase (DHCR7), showed significantly different expression according to alleles. Vitamin D 54-63 7-dehydrocholesterol reductase Homo sapiens 170-175 34852423-12 2021 Conclusion: The genetic factors underlying vitamin D deficiency in Korea included polymorphisms in the GC, PDE3B, NADSYN1, and ACTE1P genes. Vitamin D 43-52 phosphodiesterase 3B Homo sapiens 107-112 34852423-12 2021 Conclusion: The genetic factors underlying vitamin D deficiency in Korea included polymorphisms in the GC, PDE3B, NADSYN1, and ACTE1P genes. Vitamin D 43-52 NAD synthetase 1 Homo sapiens 114-121 34930854-1 2021 INTRODUCTION: Fibroblast growth factor-23 (FGF23) is responsible for regulating the metabolism of phosphorus and vitamin D by affecting the kidneys and parathyroid gland. Vitamin D 113-122 fibroblast growth factor 23 Homo sapiens 14-41 34930854-1 2021 INTRODUCTION: Fibroblast growth factor-23 (FGF23) is responsible for regulating the metabolism of phosphorus and vitamin D by affecting the kidneys and parathyroid gland. Vitamin D 113-122 fibroblast growth factor 23 Homo sapiens 43-48 34460994-15 2021 Th17/Treg ratio was imbalanced, RORgammat and IL-17 were upregulated, and Foxp 3, IL-10, and TGF-beta1 were downregulated after OVA sensitization, while vitamin D treatment inverted these changes and inhibited the NF-kappaB-p65 phosphorylation level. Vitamin D 153-162 interleukin 17A Mus musculus 46-51 34884710-0 2021 The Effects of Vitamin D on the Expression of IL-33 and Its Receptor ST2 in Skin Cells; Potential Implication for Psoriasis. Vitamin D 15-24 ST2 Homo sapiens 69-72 34884710-8 2021 Furthermore, the effect of vitamin D on expression of IL-33 and ST2 was VDR-dependent. Vitamin D 27-36 ST2 Homo sapiens 64-67 34884710-8 2021 Furthermore, the effect of vitamin D on expression of IL-33 and ST2 was VDR-dependent. Vitamin D 27-36 vitamin D receptor Homo sapiens 72-75 34727991-11 2021 If responses to vitamin D supplementation could be modified by VDR SNPs, determining the distribution of VDR polymorphisms in both breast cancer survivors and healthy populations will provide a new insight into the vitamin D requirements of individuals to prevent cancer and its related mortality based on their genotypes. Vitamin D 16-25 vitamin D receptor Homo sapiens 63-66 34727991-11 2021 If responses to vitamin D supplementation could be modified by VDR SNPs, determining the distribution of VDR polymorphisms in both breast cancer survivors and healthy populations will provide a new insight into the vitamin D requirements of individuals to prevent cancer and its related mortality based on their genotypes. Vitamin D 16-25 vitamin D receptor Homo sapiens 105-108 34727991-11 2021 If responses to vitamin D supplementation could be modified by VDR SNPs, determining the distribution of VDR polymorphisms in both breast cancer survivors and healthy populations will provide a new insight into the vitamin D requirements of individuals to prevent cancer and its related mortality based on their genotypes. Vitamin D 215-224 vitamin D receptor Homo sapiens 105-108 34732414-2 2021 Vitamin D signaling is mediated by vitamin D receptor (VDR) activated by 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) and is also important in intestinal functions, such as calcium absorption and epithelial barrier maintenance. Vitamin D 0-9 vitamin D receptor Homo sapiens 35-53 34732414-2 2021 Vitamin D signaling is mediated by vitamin D receptor (VDR) activated by 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) and is also important in intestinal functions, such as calcium absorption and epithelial barrier maintenance. Vitamin D 0-9 vitamin D receptor Homo sapiens 55-58 34147708-3 2021 Elevated FGF23 results in renal phosphate wasting and compromised vitamin D activation, ultimately resulting in osteomalacia. Vitamin D 66-75 fibroblast growth factor 23 Homo sapiens 9-14 34486787-4 2021 Here, it is aimed to investigate the effect of vitamin D-related polymorphisms (VDBP and VDR) and cholesterol-related variants of ApoE on Turkish MS patients. Vitamin D 47-56 GC vitamin D binding protein Homo sapiens 80-84 34486787-4 2021 Here, it is aimed to investigate the effect of vitamin D-related polymorphisms (VDBP and VDR) and cholesterol-related variants of ApoE on Turkish MS patients. Vitamin D 47-56 vitamin D receptor Homo sapiens 89-92 34324883-0 2021 Vitamin D deficiency attenuates endothelial function by reducing antioxidant activity and vascular eNOS expression in the rat microcirculation. Vitamin D 0-9 nitric oxide synthase 3 Rattus norvegicus 99-103 34324883-10 2021 In conclusion, vitamin D deficiency impaired microvascular vasodilation, associated with eNOS downregulation and reduced antioxidant activity. Vitamin D 15-24 nitric oxide synthase 3 Rattus norvegicus 89-93 34510707-0 2021 The complex ABCG5/ABCG8 Regulates Vitamin D Absorption Rate and Contributes to its Efflux from the Intestine. Vitamin D 34-43 ATP binding cassette subfamily G member 8 Homo sapiens 18-23 34450383-0 2021 Vitamin D suppressed gastric cancer cell growth through downregulating CD44 expression in vitro and in vivo. Vitamin D 0-9 CD44 molecule (Indian blood group) Homo sapiens 71-75 34450383-14 2021 RESULTS: The results showed that the active form of vitamin D, 1,25(OH)2D3, had a remarkable inhibitory effect in CD44-expressing human GC MKN45 and KATO III cells, but not in CD44-null MKN28 cells. Vitamin D 52-61 CD44 molecule (Indian blood group) Homo sapiens 114-118 34450383-18 2021 In an orthotopic GC nude mice model, both oral intake of vitamin D and intraperitoneal injection with 1,25(OH)2D3 could significantly inhibit orthotopic GC growth and CD44 expression in vivo. Vitamin D 57-66 CD44 antigen Mus musculus 167-171 34273568-14 2021 The three genes are associated with inflammation control and arthritis, and SSH2 and NLRP1are also related to vitamin D modulation. Vitamin D 110-119 slingshot protein phosphatase 2 Homo sapiens 76-80 34717752-17 2021 These data indicate the importance of megalin in BMMSCs for vitamin D"s role in skeletal health. Vitamin D 60-69 LDL receptor related protein 2 Rattus norvegicus 38-45 34304574-1 2021 BACKGROUND: the biological activity of vitamin D depends on the activity of its receptor or VDR. Vitamin D 39-48 vitamin D receptor Homo sapiens 92-95 34304574-4 2021 Secondly, it was to verify if the status of some metabolic factors (oxidative stress, inflammation, lipid profile, and glycemia) in the serum, and gender-adjusted vitamin D levels are independent factors with an influence on the VDR methylation profile. Vitamin D 163-172 vitamin D receptor Homo sapiens 229-232 34304574-9 2021 CONCLUSION: we conclude that the methylation profile of the VDR gene is not influenced by the different BsmI polymorphism genotypes, and that serum vitamin D and serum markers of oxidative stress and inflammation can modulate this profile. Vitamin D 148-157 vitamin D receptor Homo sapiens 60-63 34950827-1 2021 Apart from its phosphaturic action, the bone-derived hormone fibroblast growth factor-23 (FGF23) is also an essential regulator of vitamin D metabolism. Vitamin D 131-140 fibroblast growth factor 23 Homo sapiens 61-88 34950827-1 2021 Apart from its phosphaturic action, the bone-derived hormone fibroblast growth factor-23 (FGF23) is also an essential regulator of vitamin D metabolism. Vitamin D 131-140 fibroblast growth factor 23 Homo sapiens 90-95 34950827-2 2021 The main target organ of FGF23 is the kidney, where FGF23 suppresses transcription of the key enzyme in vitamin D hormone (1,25(OH)2D) activation, 1alpha-hydroxylase, and activates transcription of the key enzyme responsible for vitamin D degradation, 24-hydroxylase, in proximal renal tubules. Vitamin D 104-113 fibroblast growth factor 23 Homo sapiens 25-30 34950827-2 2021 The main target organ of FGF23 is the kidney, where FGF23 suppresses transcription of the key enzyme in vitamin D hormone (1,25(OH)2D) activation, 1alpha-hydroxylase, and activates transcription of the key enzyme responsible for vitamin D degradation, 24-hydroxylase, in proximal renal tubules. Vitamin D 104-113 fibroblast growth factor 23 Homo sapiens 52-57 34950827-2 2021 The main target organ of FGF23 is the kidney, where FGF23 suppresses transcription of the key enzyme in vitamin D hormone (1,25(OH)2D) activation, 1alpha-hydroxylase, and activates transcription of the key enzyme responsible for vitamin D degradation, 24-hydroxylase, in proximal renal tubules. Vitamin D 229-238 fibroblast growth factor 23 Homo sapiens 25-30 34950827-2 2021 The main target organ of FGF23 is the kidney, where FGF23 suppresses transcription of the key enzyme in vitamin D hormone (1,25(OH)2D) activation, 1alpha-hydroxylase, and activates transcription of the key enzyme responsible for vitamin D degradation, 24-hydroxylase, in proximal renal tubules. Vitamin D 229-238 fibroblast growth factor 23 Homo sapiens 52-57 34950827-4 2021 The importance of FGF23 as regulator of vitamin D metabolism is underscored by the fact that in the absence of FGF23 signaling, the tight control of renal 1alpha-hydroxylase fails, resulting in overproduction of 1,25(OH)2D in mice and men. Vitamin D 40-49 fibroblast growth factor 23 Mus musculus 18-23 34950827-5 2021 During recent years, big strides have been made toward a more complete understanding of the mechanisms underlying the FGF23-mediated regulation of vitamin D metabolism, especially at the genomic level. Vitamin D 147-156 fibroblast growth factor 23 Homo sapiens 118-123 34950827-8 2021 The purpose of this review is to highlight our current understanding of the molecular mechanisms underlying the regulation of vitamin D metabolism by FGF23, and to discuss the role of these mechanisms in physiology and pathophysiology. Vitamin D 126-135 fibroblast growth factor 23 Homo sapiens 150-155 34642495-0 2022 Correction: The effect of vitamin D on fibroblast growth factor 23: a systematic review and meta-analysis of randomized controlled trials. Vitamin D 26-35 fibroblast growth factor 23 Homo sapiens 39-66 34617343-2 2021 It has also been reported that vitamin D deficiency may play a role in this, possibly because of the multi-gene regulatory function of the vitamin D receptor. Vitamin D 31-40 vitamin D receptor Homo sapiens 139-157 34617343-8 2021 All the included studies found that supplementation of vitamin D (D2 and D3 ), regardless of dosage, increased 25(OH)D levels compared to a placebo. Vitamin D 55-64 immunoglobulin heavy diversity 2-15 Homo sapiens 66-75 34616834-1 2021 This study provides novel insights into mechanisms of traffic-related air pollution-induced allergy by down-regulation via complement regulators (CFI, PROS1 and PLG) and its interaction with vitamin D deficiency via the complement inhibitor PLG https://bit.ly/3x0jYOw. Vitamin D 191-200 complement factor I Homo sapiens 146-149 34562689-8 2021 RESULTS: Age, gender, Sequential Organ Failure Assessment (SOFA), Simplified Acute Physiology Score III (SAPS3) and season of admission were identified by the LASSO regression analysis as significant predictors of vitamin D severe deficiency at ICU admission. Vitamin D 214-223 protein phosphatase 6 regulatory subunit 3 Homo sapiens 105-110 34562448-2 2021 This antiviral role of vitamin D is widely attributed to Vitamin D Receptor (VDR)/Retinoid X Receptor (RXR)-mediated regulation of host immunomodulatory genes through Vitamin D Response Elements (VDREs) in their promoters. Vitamin D 23-32 vitamin D receptor Homo sapiens 57-75 34562448-2 2021 This antiviral role of vitamin D is widely attributed to Vitamin D Receptor (VDR)/Retinoid X Receptor (RXR)-mediated regulation of host immunomodulatory genes through Vitamin D Response Elements (VDREs) in their promoters. Vitamin D 23-32 vitamin D receptor Homo sapiens 77-80 34562448-2 2021 This antiviral role of vitamin D is widely attributed to Vitamin D Receptor (VDR)/Retinoid X Receptor (RXR)-mediated regulation of host immunomodulatory genes through Vitamin D Response Elements (VDREs) in their promoters. Vitamin D 23-32 retinoid X receptor alpha Homo sapiens 103-106 34562448-2 2021 This antiviral role of vitamin D is widely attributed to Vitamin D Receptor (VDR)/Retinoid X Receptor (RXR)-mediated regulation of host immunomodulatory genes through Vitamin D Response Elements (VDREs) in their promoters. Vitamin D 167-176 vitamin D receptor Homo sapiens 57-75 34562448-2 2021 This antiviral role of vitamin D is widely attributed to Vitamin D Receptor (VDR)/Retinoid X Receptor (RXR)-mediated regulation of host immunomodulatory genes through Vitamin D Response Elements (VDREs) in their promoters. Vitamin D 167-176 vitamin D receptor Homo sapiens 77-80 34562448-2 2021 This antiviral role of vitamin D is widely attributed to Vitamin D Receptor (VDR)/Retinoid X Receptor (RXR)-mediated regulation of host immunomodulatory genes through Vitamin D Response Elements (VDREs) in their promoters. Vitamin D 167-176 retinoid X receptor alpha Homo sapiens 103-106 34562448-11 2021 Our findings (a) identify VDR as a novel regulator of HBV-core promoter activity, (b) explain at least in part the correlation of vitamin D levels to HBV activity in clinical studies, (c) have implications on the potential use of vitamin D along with anti-HBV therapies, and (d) lay the groundwork for studies on vitamin D-mediated regulation of viruses through VDREs in virus promoters. Vitamin D 313-322 vitamin D receptor Homo sapiens 26-29 34087410-3 2021 Calcitriol (1,25-dihydroxyvitamin D3) and retinoic acid possess hormone-like properties and are the bioactive metabolites of vitamin D and A, respectively, that signal through heterodimers containing the common retinoid X receptor. Vitamin D 125-134 retinoid X receptor alpha Homo sapiens 211-230 34723751-0 2021 Vitamin D binding protein and its polymorphisms may explain the link between vitamin D deficiency and COVID-19. Vitamin D 77-86 GC vitamin D binding protein Homo sapiens 0-25 34246812-7 2021 Gene expression profiles for other known fibroblast immune mediators (SAA3 and CCL20) did not show significant differences between haplotypes but NOS2 gene expression was significantly elevated in response to vitamin D, even above the level detected in response to both TLR ligands. Vitamin D 209-218 nitric oxide synthase 2 Bos taurus 146-150 34389701-0 2021 The effect of daily intake of vitamin D-fortified yogurt drink, with and without added calcium, on serum adiponectin and sirtuins 1 and 6 in adult subjects with type 2 diabetes. Vitamin D 30-39 sirtuin 1 Homo sapiens 121-137 34389701-2 2021 This study aimed to evaluate the effects of daily intake of vitamin D-fortified yogurt drink, either with or without added calcium, on serum adiponectin, sirtuins (SIRT)1 and 6. Vitamin D 60-69 sirtuin 1 Homo sapiens 154-176 34389701-11 2021 CONCLUSIONS: Daily consumption of vitamin D-fortified yogurt drink for 12 weeks resulted in an increase in circulating concentrations of SIRT1 and SIRT6 in T2D subjects and D+Ca-fortified yogurt drink was more in favor of SIRT6 increment. Vitamin D 34-43 sirtuin 1 Homo sapiens 137-142 34315477-10 2021 However, genetically regulated 25(OH)D deficiency due to vitamin D synthesis gene (DHCR7) may influence the risk of T2D. Vitamin D 57-66 7-dehydrocholesterol reductase Homo sapiens 83-88 34296353-1 2022 Fibroblast growth factor 23 (FGF-23), a hormone mainly secreted by osteocytes and osteoblasts, regulates phosphate and vitamin D levels. Vitamin D 119-128 fibroblast growth factor 23 Homo sapiens 0-27 34296353-1 2022 Fibroblast growth factor 23 (FGF-23), a hormone mainly secreted by osteocytes and osteoblasts, regulates phosphate and vitamin D levels. Vitamin D 119-128 fibroblast growth factor 23 Homo sapiens 29-35 34225707-2 2021 In this study, we quantified Vitamin D Binding Protein (VitDBP) levels in saliva as a measure of Vitamin D during orthodontic tooth movement. Vitamin D 97-106 GC vitamin D binding protein Homo sapiens 29-54 34225707-2 2021 In this study, we quantified Vitamin D Binding Protein (VitDBP) levels in saliva as a measure of Vitamin D during orthodontic tooth movement. Vitamin D 97-106 GC vitamin D binding protein Homo sapiens 56-62 34210242-8 2021 CONCLUSION: Vitamin D plus magnesium supplementation in obese women with mild to moderate depressive symptoms has beneficial influences on mood, serum levels of BDNF, inflammation, and SIRT1. Vitamin D 12-21 brain derived neurotrophic factor Homo sapiens 161-165 34210242-8 2021 CONCLUSION: Vitamin D plus magnesium supplementation in obese women with mild to moderate depressive symptoms has beneficial influences on mood, serum levels of BDNF, inflammation, and SIRT1. Vitamin D 12-21 sirtuin 1 Homo sapiens 185-190 34249156-15 2021 The NF is a bioavailable source of the biologically active metabolite of vitamin D, i.e. 1,25-dihydroxyvitamin D. Vitamin D 73-82 neurofascin Homo sapiens 4-6 34097028-6 2021 A Vitamin D panel revealed a severely elevated parathyroid hormone level. Vitamin D 2-11 parathyroid hormone Felis catus 47-66 34621381-0 2021 25-OH Vitamin D blood serum linkage with VDR gene polymorphism (rs2228570) in thyroid pathology patients in the West-Ukrainian population. Vitamin D 6-15 vitamin D receptor Homo sapiens 41-44 34621381-4 2021 The study"s objective was to investigate the association between VDR gene polymorphism (rs2228570) with blood serum levels of 25-OH vitamin D in patients with thyroid pathology from western Ukraine. Vitamin D 132-141 vitamin D receptor Homo sapiens 65-68 34234589-1 2021 Background: Vitamin D deficiency (VDD) and insufficiency (VDI) is a public health problem worldwide. Vitamin D 12-21 VDI Homo sapiens 58-61 34166428-3 2021 Vitamin D regulates immune responses through the vitamin D receptor on CD4 cells. Vitamin D 0-9 vitamin D receptor Homo sapiens 49-67 34206371-3 2021 The nuclear vitamin D receptor (VDR) is crucial for the phenotypic effects of vitamin D hydroxyderivatives. Vitamin D 78-87 vitamin D receptor Homo sapiens 12-30 34206371-3 2021 The nuclear vitamin D receptor (VDR) is crucial for the phenotypic effects of vitamin D hydroxyderivatives. Vitamin D 78-87 vitamin D receptor Homo sapiens 32-35 34206371-8 2021 These results indicate that expression of VDR is important for the inhibition of melanoma growth induced by activated forms of vitamin D. Vitamin D 127-136 vitamin D receptor Homo sapiens 42-45 34239695-9 2021 The patients from the vitamin D sufficient cluster also had a significantly higher level of vitamin D/MPO, vitamin D/XO, vitamin D/MDA, vitamin D/CAT, and vitamin D/TRC than that in the vitamin deficient and insufficient clusters. Vitamin D 22-31 tRNA-Cys (GCA) 24-1 Homo sapiens 165-168 34239695-10 2021 The vitamin D deficient cluster included significantly younger patients and had a significantly lower level of AOPP/TRC and albumin/TRC than the vitamin D sufficient cluster. Vitamin D 4-13 tRNA-Cys (GCA) 24-1 Homo sapiens 116-119 34239695-10 2021 The vitamin D deficient cluster included significantly younger patients and had a significantly lower level of AOPP/TRC and albumin/TRC than the vitamin D sufficient cluster. Vitamin D 4-13 tRNA-Cys (GCA) 24-1 Homo sapiens 132-135 34208589-8 2021 It should also be underlined that many types of cancer cells present alterations in vitamin D metabolism and action as a result of Vitamin D Receptor (VDR) and CYP27B1 expression dysregulation. Vitamin D 84-93 vitamin D receptor Homo sapiens 131-149 34208589-8 2021 It should also be underlined that many types of cancer cells present alterations in vitamin D metabolism and action as a result of Vitamin D Receptor (VDR) and CYP27B1 expression dysregulation. Vitamin D 84-93 vitamin D receptor Homo sapiens 151-154 34208603-4 2021 Therefore, this study aimed to evaluate the association of VDR polymorphisms with susceptibility to psoriasis, effectiveness of NB-UVB phototherapy and concentration of proinflammatory cytokines and vitamin D amongst the Polish population. Vitamin D 199-208 vitamin D receptor Homo sapiens 59-62 34203792-8 2021 Burosumab binds circulating intact FGF23 and blocks its biological effects in target tissues, resulting in increased serum inorganic phosphate (Pi) concentrations and increased conversion of inactive vitamin D to active 1,25-vitD. Vitamin D 200-209 fibroblast growth factor 23 Homo sapiens 35-40 34069442-5 2021 Activation of VDR with vitamin D (VitD), either calcitriol or its synthetic analog EB1089, sensitized MCF-7-derived, antiestrogen-resistant LCC9 human breast cancer cells to TAM, and attenuated increased UPR and pro-survival autophagy. Vitamin D 23-32 vitamin D receptor Homo sapiens 14-17 34091780-3 2021 This ligand (vitamin D) and receptors (VDR-RXR) complex together triggers downstream DNA damage response in the cell and thus counters cancer in blood. Vitamin D 13-22 vitamin D receptor Homo sapiens 39-42 34091780-3 2021 This ligand (vitamin D) and receptors (VDR-RXR) complex together triggers downstream DNA damage response in the cell and thus counters cancer in blood. Vitamin D 13-22 retinoid X receptor alpha Homo sapiens 43-46 34091780-10 2021 Also, the mRNA expression of VDR showed a positive and non-significant relationship with vitamin D levels and RXR expression (p > 0.05). Vitamin D 89-98 vitamin D receptor Homo sapiens 29-32 34251342-2 2021 It has been established that vitamin D deficiency is one of DKD risk factors, which may be related to vitamin D receptor (VDR) polymorphisms. Vitamin D 29-38 vitamin D receptor Homo sapiens 102-120 34251342-2 2021 It has been established that vitamin D deficiency is one of DKD risk factors, which may be related to vitamin D receptor (VDR) polymorphisms. Vitamin D 29-38 vitamin D receptor Homo sapiens 122-125 34540161-6 2021 Results: The mean serum vitamin D level was 19.91 ng/ml in the case group and 22.87 ng/ml in the control group. Vitamin D 24-33 thrombopoietin Mus musculus 53-55 34540161-6 2021 Results: The mean serum vitamin D level was 19.91 ng/ml in the case group and 22.87 ng/ml in the control group. Vitamin D 24-33 thrombopoietin Mus musculus 87-89 34408615-2 2021 Adjunctive vitamin D therapy may activate the Wnt/beta-catenin pathway that results in cell differentiation and proliferation via stem cell signalling. Vitamin D 11-20 catenin (cadherin associated protein), beta 1 Mus musculus 50-62 34408615-7 2021 Results: beta-catenin and KRT20 showed a significant increase in the proliferation index of vitamin D at a dose of 0.6 mug/25.0 g (91.50 +- 4.09 and 48.75 +- 2.28, respectively; p < 0.05) compared to the colitis group. Vitamin D 92-101 catenin (cadherin associated protein), beta 1 Mus musculus 9-21 35631254-2 2022 This has been demonstrated by studies showing that vitamin D deficiency is associated with pancreatitis and its anti-inflammatory and anti-fibrotic effects by binding with the vitamin D receptor (VDR). Vitamin D 51-60 vitamin D receptor Homo sapiens 176-194 35631254-2 2022 This has been demonstrated by studies showing that vitamin D deficiency is associated with pancreatitis and its anti-inflammatory and anti-fibrotic effects by binding with the vitamin D receptor (VDR). Vitamin D 51-60 vitamin D receptor Homo sapiens 196-199 35631254-4 2022 In this narrative review, we discuss the recent advances in our understanding of the molecular mechanisms involved in vitamin D/VDR signaling in pancreatic cells; the evidence from observational studies and clinical trials that demonstrate the connection among vitamin D, pancreatitis and pancreatitis-related complications; and the route of administration of vitamin D supplementation in clinical practice. Vitamin D 118-127 vitamin D receptor Homo sapiens 128-131 35631254-4 2022 In this narrative review, we discuss the recent advances in our understanding of the molecular mechanisms involved in vitamin D/VDR signaling in pancreatic cells; the evidence from observational studies and clinical trials that demonstrate the connection among vitamin D, pancreatitis and pancreatitis-related complications; and the route of administration of vitamin D supplementation in clinical practice. Vitamin D 261-270 vitamin D receptor Homo sapiens 128-131 35607362-7 2022 We also observed that although the total daily PUFA dosage that exhibited beneficial effects was in the range of 0.7-2 g EPA and 0.4-0.8 g DHA daily, with an administration period of three weeks to four months, positive vitamin D-based supplementation effects were observed after administering doses of 2000 IU/day or 50,000 IU/week between 8 weeks and 24 months. Vitamin D 220-229 pumilio RNA binding family member 3 Homo sapiens 47-51 35620386-10 2022 Interestingly, the PVH neurons of both sexes were activated by exogenous vitamin D (1,25-dihydroxyvitamin D3), an effect dependent upon the VDR. Vitamin D 73-82 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 140-143 35526529-11 2022 ChIP assays demonstrated the presence of a vitamin D response element (VDRE) in the nestin promoter, and paricalcitol enhanced the binding of VDR to VDRE. Vitamin D 43-52 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 142-145 35334282-5 2022 Patients with vitamin D deficiency show worse renal function reflected by postoperative glomerular filtration rate (GFR) and more release of proinflammatory cytokine IL-1beta and IL-18. Vitamin D 14-23 interleukin 18 Homo sapiens 179-184 35166042-4 2022 METHODS: The expression of vitamin D pathway components CYP27B1, CYP24A1, and VDR was examined in brains obtained from PD patients (Braak stage 6; n = 9) and control subjects (n = 4). Vitamin D 27-36 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 65-72 35166042-4 2022 METHODS: The expression of vitamin D pathway components CYP27B1, CYP24A1, and VDR was examined in brains obtained from PD patients (Braak stage 6; n = 9) and control subjects (n = 4). Vitamin D 27-36 vitamin D receptor Homo sapiens 78-81 35339045-2 2022 Vitamin D has an anti-inflammatory effect on T helper cells and can affect onset and pathogenesis of MS. Two genes of the metabolic Vitamin D pathway expressed by activated T helper (Th) cells have been identified as MS risk genes by genome-wide association studies, CYP27B1 (25(OH)D3 1-alpha-hydroxylase) and CYP24A1 (1,25(OH)2D3 24-alpha-hydroxylase). Vitamin D 0-9 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 310-317 35339045-2 2022 Vitamin D has an anti-inflammatory effect on T helper cells and can affect onset and pathogenesis of MS. Two genes of the metabolic Vitamin D pathway expressed by activated T helper (Th) cells have been identified as MS risk genes by genome-wide association studies, CYP27B1 (25(OH)D3 1-alpha-hydroxylase) and CYP24A1 (1,25(OH)2D3 24-alpha-hydroxylase). Vitamin D 132-141 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 310-317 35406694-1 2022 Vitamin D receptor (VDR) executes most of the biological functions of vitamin D. Vitamin D 70-79 vitamin D receptor Homo sapiens 0-18 35406694-1 2022 Vitamin D receptor (VDR) executes most of the biological functions of vitamin D. Vitamin D 70-79 vitamin D receptor Homo sapiens 20-23 35338345-8 2022 We identified the Vitamin D response element (VDRE) binding sites in a reporter system showed that VDRE in the Claudin-5 promoter is required for vitamin D3-induced Claudin-5 expression. Vitamin D 18-27 claudin 5 Mus musculus 111-120 35338345-8 2022 We identified the Vitamin D response element (VDRE) binding sites in a reporter system showed that VDRE in the Claudin-5 promoter is required for vitamin D3-induced Claudin-5 expression. Vitamin D 18-27 claudin 5 Mus musculus 165-174 35370605-0 2022 Mediation Effects of IL-1beta and IL-18 on the Association Between Vitamin D Levels and Mild Cognitive Impairment Among Chinese Older Adults: A Case-Control Study in Taiyuan, China. Vitamin D 67-76 interleukin 18 Homo sapiens 34-39 35001797-2 2022 Vitamin D exerts its effect through vitamin receptor (VDR), and various single nucleotide polymorphisms have been reported to affects the expression and structure of the VDR. Vitamin D 0-9 vitamin D receptor Homo sapiens 54-57 35001797-2 2022 Vitamin D exerts its effect through vitamin receptor (VDR), and various single nucleotide polymorphisms have been reported to affects the expression and structure of the VDR. Vitamin D 0-9 vitamin D receptor Homo sapiens 170-173 35001797-5 2022 Genetic variants in the VDR (FokI, TaqI, BsmI, and ApaI) were genotyped by TaqMan assay.Results: Reduced serum Vitamin D level was observed in subjects with sepsis compared to healthy controls (p <= 0.0001). Vitamin D 111-120 vitamin D receptor Homo sapiens 24-27 35318258-8 2022 RESULTS: We show that serum level of vitamin D is negatively correlated with expression of programmed cell death-1 (PD-1), T-cell immunoreceptor with Ig and ITIM domains (TIGIT), and T-cell immunoglobulin and mucin-domain containing-3 (Tim-3), but positively correlated with CD28 expression on CD8+ and Vgamma9Vdelta2+ T cells in patients with NSCLC. Vitamin D 37-46 hepatitis A virus cellular receptor 2 Homo sapiens 236-241 35318258-8 2022 RESULTS: We show that serum level of vitamin D is negatively correlated with expression of programmed cell death-1 (PD-1), T-cell immunoreceptor with Ig and ITIM domains (TIGIT), and T-cell immunoglobulin and mucin-domain containing-3 (Tim-3), but positively correlated with CD28 expression on CD8+ and Vgamma9Vdelta2+ T cells in patients with NSCLC. Vitamin D 37-46 CD28 Sus scrofa 275-279 35318258-9 2022 1alpha,25(OH)2D3, the active form of vitamin D, promotes the nuclear translocation of VDR, which binds to the promoter region of Pdcd1, Tim3, and Tigit genes and inhibits their expression. Vitamin D 37-46 vitamin D receptor Homo sapiens 86-89 35318258-9 2022 1alpha,25(OH)2D3, the active form of vitamin D, promotes the nuclear translocation of VDR, which binds to the promoter region of Pdcd1, Tim3, and Tigit genes and inhibits their expression. Vitamin D 37-46 hepatitis A virus cellular receptor 2 Homo sapiens 136-140 35084563-1 2022 Fibroblast growth factor 23 (FGF23) is an important bone hormone that regulates phosphate homeostasis in the kidney along with active vitamin D (1,25(OH)2D3) and parathyroid hormone (PTH). Vitamin D 134-143 fibroblast growth factor 23 Homo sapiens 0-27 35084563-1 2022 Fibroblast growth factor 23 (FGF23) is an important bone hormone that regulates phosphate homeostasis in the kidney along with active vitamin D (1,25(OH)2D3) and parathyroid hormone (PTH). Vitamin D 134-143 fibroblast growth factor 23 Homo sapiens 29-34 35202418-9 2022 After vitamin D supplementation 25(OH)D, 1,25(OH)2D, PTH and VDBP levels were changed significantly compared to the placebo group. Vitamin D 6-15 GC vitamin D binding protein Homo sapiens 61-65 35090436-1 2022 BACKGROUND: Tumor-induced osteomalacia (TIO) is a rare, acquired disease of renal phosphate wasting and disturbed vitamin D homeostasis as a result of the action of a phosphaturic protein - FGF-23, produced by a neoplasm. Vitamin D 114-123 fibroblast growth factor 23 Homo sapiens 190-196 35084728-0 2022 The effect of vitamin D on GATA3 gene expression in peripheral blood mononuclear cells in allergic asthma. Vitamin D 14-23 GATA binding protein 3 Homo sapiens 27-32 35084728-6 2022 In this study, given its immunomodulatory properties, we aimed to investigate the effects of different concentrations of vitamin D on GATA3 gene expression in peripheral blood mononuclear cells (PBMCs), including Th2 cells, and compare GATA3 expression levels between PBMCs taken from allergic asthmatic patients and healthy controls. Vitamin D 121-130 GATA binding protein 3 Homo sapiens 134-139 35084728-9 2022 In addition, in the control group, cells co-cultured with vitamin D had a significantly increased GATA3 expression. Vitamin D 58-67 GATA binding protein 3 Homo sapiens 98-103 35084728-11 2022 By contrast, incubation with vitamin D at the concentration of 10-6 M slightly decreased the expression of GATA3 among patients. Vitamin D 29-38 GATA binding protein 3 Homo sapiens 107-112 35084728-12 2022 CONCLUSION: In summary, it is likely that vitamin D should regulate GATA3 gene expression in the PBMCs in a dose-dependent manner. Vitamin D 42-51 GATA binding protein 3 Homo sapiens 68-73 35208518-5 2022 In Hashimoto"s disease, vitamin D deficiency appears to be correlated with a higher titer of anti-TPO antibodies and with thyroid volume, and supplementation was associated with reduction of antibodies in some studies. Vitamin D 24-33 thyroid peroxidase Homo sapiens 98-101 34935629-2 2022 It exerts its biological functions by binding to the vitamin D receptor (VDR), a transcription factor that regulates gene expression in vitamin D-target tissues such as intestine, kidney and bone. Vitamin D 136-145 vitamin D receptor Homo sapiens 53-71 34935629-2 2022 It exerts its biological functions by binding to the vitamin D receptor (VDR), a transcription factor that regulates gene expression in vitamin D-target tissues such as intestine, kidney and bone. Vitamin D 136-145 vitamin D receptor Homo sapiens 73-76 35386604-17 2022 Similarities in the biochemical profiles of HHRH and CYP24A1 deficiency suggest elevated active vitamin D and hypercalciuria may be potential cystogenic factors. Vitamin D 96-105 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 53-60 35057792-12 2022 A new subset of macrophages with M2-type polarization double expressed MLPH + /CD206 + was found in mice having pneumoconiosis but markedly decreased after the Vitamin D treatment. Vitamin D 160-169 mannose receptor, C type 1 Mus musculus 79-84 35057792-13 2022 Activated MLPH + /CD206 + M2 macrophages secreted TGF-beta1 and are sensitive to Vitamin D treatment. Vitamin D 81-90 mannose receptor, C type 1 Mus musculus 18-23 34979083-2 2022 A significant regulator of vitamin-D metabolism is the inactivating function of the mitochondrial enzyme cytochrome P450 24A1 (CYP24A1). Vitamin D 27-36 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 105-125 34979083-2 2022 A significant regulator of vitamin-D metabolism is the inactivating function of the mitochondrial enzyme cytochrome P450 24A1 (CYP24A1). Vitamin D 27-36 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 127-134 34979083-10 2022 Taken together, this work presents an example of production of a challenging human CYP as well as providing details regarding hydrophobic modulation of a CYP-Adx complex that is critical to human vitamin-D metabolism. Vitamin D 196-205 ferredoxin 1 Homo sapiens 158-161 35045292-3 2022 In this study, we report the occurrence of vitamin D-specific DNA demethylation and transcriptional activation at VDR binding sites associated with the acquisition of tolerogenesis in vitro. Vitamin D 43-52 vitamin D receptor Homo sapiens 114-117 35055118-1 2022 The purpose of the study was to investigate the role of vitamin D binding protein (VDBP, DBP) and its polymorphism in the vitamin D pathway and human health. Vitamin D 122-131 GC vitamin D binding protein Homo sapiens 56-81 35055118-1 2022 The purpose of the study was to investigate the role of vitamin D binding protein (VDBP, DBP) and its polymorphism in the vitamin D pathway and human health. Vitamin D 122-131 GC vitamin D binding protein Homo sapiens 83-87 35055118-4 2022 Vitamin D binding protein bonds vitamin D and its metabolites and transports them to target tissues. Vitamin D 32-41 GC vitamin D binding protein Homo sapiens 0-25 35055118-8 2022 In this review, we aim to systematize the knowledge regarding the occurrence of diseases and their relationship with vitamin D deficiencies, which may be caused by polymorphisms in the VDBP gene. Vitamin D 117-126 GC vitamin D binding protein Homo sapiens 185-189 35057541-0 2022 Vitamin D Receptor (VDR) Gene Polymorphisms Modify the Response to Vitamin D Supplementation: A Systematic Review and Meta-Analysis. Vitamin D 67-76 vitamin D receptor Homo sapiens 0-18 35057541-0 2022 Vitamin D Receptor (VDR) Gene Polymorphisms Modify the Response to Vitamin D Supplementation: A Systematic Review and Meta-Analysis. Vitamin D 67-76 vitamin D receptor Homo sapiens 20-23 35057541-2 2022 VDR is regulated by genetic and environmental factors and it is hypothesised that the response to vitamin D supplementation could be modulated by genetic variants in the VDR gene. Vitamin D 98-107 vitamin D receptor Homo sapiens 0-3 35057541-2 2022 VDR is regulated by genetic and environmental factors and it is hypothesised that the response to vitamin D supplementation could be modulated by genetic variants in the VDR gene. Vitamin D 98-107 vitamin D receptor Homo sapiens 170-173 35053549-0 2022 Polymorphism of VDR Gene and the Sensitivity of Human Leukemia and Lymphoma Cells to Active Forms of Vitamin D. Vitamin D 101-110 vitamin D receptor Homo sapiens 16-19 35057465-5 2022 Transcription of the human AMP genes beta-defensin 2/defensin-beta4 (HBD2/DEFB4) and cathelicidin antimicrobial peptide (CAMP) is stimulated by the VDR bound to promoter-proximal vitamin D response elements. Vitamin D 179-188 vitamin D receptor Homo sapiens 148-151 35053218-10 2022 Despite conventional function as co-factor with fibroblast growth factor-23 (FGF23) that regulates phosphate and vitamin D homeostasis, FGF23-independent soluble Klotho protein may act on multiple signal pathways in different organs and tissue in roles of anti-aging and protection from metabolic syndrome. Vitamin D 113-122 fibroblast growth factor 23 Homo sapiens 77-82 35053218-10 2022 Despite conventional function as co-factor with fibroblast growth factor-23 (FGF23) that regulates phosphate and vitamin D homeostasis, FGF23-independent soluble Klotho protein may act on multiple signal pathways in different organs and tissue in roles of anti-aging and protection from metabolic syndrome. Vitamin D 113-122 klotho Homo sapiens 162-168 34979905-1 2022 BACKGROUND: Calcitriol (an active metabolite of vitamin D) modulates the expression of hundreds of human genes by activation of the vitamin D nuclear receptor (VDR). Vitamin D 48-57 vitamin D receptor Homo sapiens 132-158 34979905-1 2022 BACKGROUND: Calcitriol (an active metabolite of vitamin D) modulates the expression of hundreds of human genes by activation of the vitamin D nuclear receptor (VDR). Vitamin D 48-57 vitamin D receptor Homo sapiens 160-163 35145798-17 2022 In this case report, we want to highlight the paramount importance of adequate tumor screening in adult patients with acquired hypophosphatemia, and the crucial lead that phosphate and vitamin D regulating hormones (FGF23) have for suspecting TIO. Vitamin D 185-194 fibroblast growth factor 23 Homo sapiens 216-221 34981556-6 2022 And the combined results indicated vitamin D supplementation significantly reduced the level of thyroid peroxidase antibodies (TPO-Ab) compared to the control group (WMD = -158.18, 95% CI: -301.92, -14.45, p = 0.031; I2 = 68.8%, pheterogeneity = 0.007). Vitamin D 35-44 thyroid peroxidase Homo sapiens 96-114 35100585-1 2022 INTRODUCTION: Vitamin D binding protein (VDBP) is correlated with non-alcoholic fatty liver disease (NAFLD) through the biological functions of regulating plasma vitamin D (VD) level and the inflammatory process. Vitamin D 162-171 GC vitamin D binding protein Homo sapiens 14-39 35100585-1 2022 INTRODUCTION: Vitamin D binding protein (VDBP) is correlated with non-alcoholic fatty liver disease (NAFLD) through the biological functions of regulating plasma vitamin D (VD) level and the inflammatory process. Vitamin D 162-171 GC vitamin D binding protein Homo sapiens 41-45 35379049-1 2022 Objective: This study aimed to evaluate the association between vitamin D receptor (an essential component in the vitamin D signaling pathway) and serum vitamin D as well as its clinical significance in papillary thyroid cancer. Vitamin D 114-123 vitamin D receptor Homo sapiens 64-82 35379049-1 2022 Objective: This study aimed to evaluate the association between vitamin D receptor (an essential component in the vitamin D signaling pathway) and serum vitamin D as well as its clinical significance in papillary thyroid cancer. Vitamin D 153-162 vitamin D receptor Homo sapiens 64-82 35379049-10 2022 Low vitamin D receptor expression in papillary thyroid cancer was shown to positively correlate with low serum vitamin D level and disease aggressiveness. Vitamin D 111-120 vitamin D receptor Homo sapiens 4-22 2656246-1 1989 The endogenous inhibitor of cAMP-dependent protein kinase (PKI) in chick kidney is regulated by the vitamin D status of the animal. Vitamin D 100-109 tyrosine kinase 2 Gallus gallus 43-57 2656246-1 1989 The endogenous inhibitor of cAMP-dependent protein kinase (PKI) in chick kidney is regulated by the vitamin D status of the animal. Vitamin D 100-109 tyrosine kinase 2 Gallus gallus 59-62 2542376-7 1989 These data provide evidence for the presence of a vitamin D microendocrine system in endothelial cells, consisting of the VDR and a 1 alpha-hydroxylase enzyme capable of producing 1,25(OH)2D3. Vitamin D 50-59 vitamin D receptor Homo sapiens 122-125 2752207-3 1989 In X-linked hypophosphatemic mice (Hyp mice) maintained on a standard diet containing vitamin D, the basal level of intestinal calbindin-D28K was much lower (average 65.13 +/- 7.39%) than that in breeding pairs of normal mice maintained under the same conditions. Vitamin D 86-95 calbindin 1 Mus musculus 127-131 2752207-4 1989 Although the mean intestinal level of calbindin-D28K was as low as 118.23 +/- 20.08 (SD) ng/mg protein in vitamin D-deficient mice (-D), the level of this protein was markedly increased to the control level (198.68 +/- 9.98 vs. 198.49 +/- 14.29 ng/mg protein of control) (P less than 0.001) in response to the administration of vitamin D3 (1000 I.U. Vitamin D 106-115 calbindin 1 Mus musculus 38-42 2752207-6 1989 These results indicate that calbindin-D28K, biochemically indistinguishable from the chick intestinal calbindin-D28K, is present in the mouse intestine, and that the lower amount of this protein in the Hyp mouse intestine may, at least in part, be responsible for the resistance to the effects of vitamin D. Vitamin D 297-306 calbindin 1 Mus musculus 28-32 3049577-2 1988 Studies of vitamin D-dependent 28-kilodalton calcium binding protein (calbindin D28) have been hindered by difficulties in purifying large amounts of the protein. Vitamin D 11-20 hippocalcin Rattus norvegicus 45-68 2889789-1 1987 The aetiology of the rise in plasma calbindin-D9K (vitamin D-induced calcium-binding protein; CaBP), following insulin-induced hypoglycaemia, was studied in the pig. Vitamin D 51-60 S100 calcium binding protein G Sus scrofa 36-49 3478696-0 1987 Calbindin-D in peripheral nerve cells is vitamin D and calcium dependent. Vitamin D 41-50 calbindin 1 Gallus gallus 0-9 3478696-1 1987 The vitamin D-induced calcium-binding protein calbindin-D (CaBP) was localized immunohistochemically in some but not all of the cell bodies and axons within the intestinalis nerve of the chicken. Vitamin D 4-13 calbindin 1 Gallus gallus 46-55 3030988-1 1987 1 alpha,25-Dihydroxyvitamin D3, a hormonally active form of vitamin D, induces anchorage-independent growth of BALB/3T3 A31-1-1 and NIH/3T3 cells with concomitant increase of their mRNA level of c-Ki-ras but not of c-Ha-ras or c-myc, through a receptor-mediated mechanism. Vitamin D 20-29 Harvey rat sarcoma virus oncogene Mus musculus 215-223 2845731-10 1986 The incubation of GR cells with other vitamin D metabolites such as 25-hydroxyvitamin D3 (25(OH)D3) at a concentration of 10(-9) M does not significantly alter cell growth or morphology. Vitamin D 38-47 interferon activated gene 205 Mus musculus 86-88 3755869-0 1986 Localization of vitamin D-dependent active Ca2+ transport in rat duodenum and relation to CaBP. Vitamin D 16-25 hippocalcin Rattus norvegicus 90-94 3755869-7 1986 It is concluded that vitamin D exerts its major regulation of active calcium transport in the rat duodenum via CaBP on transport steps beyond brush-border entry. Vitamin D 21-30 hippocalcin Rattus norvegicus 111-115 3755394-3 1986 This study was designed to determine whether calmodulin, the ubiquitous cell protein that binds and mediates many of the regulatory functions of Ca2+, plays a role in the regulation of renal vitamin D metabolism. Vitamin D 191-200 calmodulin 2 Gallus gallus 45-55 3755394-4 1986 The calmodulin antagonists trifluoperazine (TFP), Janssen R24571, and the naphthalene sulfonamides W5 and W7 inhibited conversion of 25OHD3 to 1,25-(OH)2D3 by isolated renal tubules from vitamin D-deficient chicks in a dose-dependent manner (ED50: TFP, 12 mumol/liter; R24571, 10 mumol/liter; W7, 30 mumol/liter; W5, 75 mumol/liter). Vitamin D 187-196 calmodulin 2 Gallus gallus 4-14 3768308-1 1986 It is well recognized that the vitamin D binding protein (DBP) is important for the transport of vitamin D, 25-hydroxyvitamin D (25-OH-D), and its metabolites. Vitamin D 31-40 D-box binding PAR bZIP transcription factor Rattus norvegicus 58-61 3732632-5 1986 The decreased concentrations of vitamin D metabolites in the adult Bantu diabetic patients may be partly explained by a concomitant decrease in the concentration of vitamin D-binding protein, possibly due to insulin deficiency. Vitamin D 32-41 GC vitamin D binding protein Homo sapiens 165-190 3949675-12 1986 The results demonstrated that the organoids maintained their differentiated function and tissuelike morphology for extended periods in vitro and therefore represent a suitable model system for studies on the long-term modulation of PTH secretion by vitamin D metabolites, ions, and other agents. Vitamin D 249-258 parathyroid hormone Bos taurus 232-235 4083341-0 1985 Effects of parathyroid hormone on puppies during development of Ca and vitamin D deficiency. Vitamin D 71-80 parathyroid hormone Canis lupus familiaris 11-30 3840345-8 1985 The data indicate that the most significant effect of vitamin D on kidney proteins is increased synthesis of the Mr 28,000 CaBP, suggesting that a major role of vitamin D in renal function is regulation of calcium transport at the distal tubule. Vitamin D 54-63 hippocalcin Rattus norvegicus 123-127 3840345-8 1985 The data indicate that the most significant effect of vitamin D on kidney proteins is increased synthesis of the Mr 28,000 CaBP, suggesting that a major role of vitamin D in renal function is regulation of calcium transport at the distal tubule. Vitamin D 161-170 hippocalcin Rattus norvegicus 123-127 2411531-0 1985 Cell-free translational analysis of messenger ribonucleic acid coding for vitamin D-dependent rat renal calcium-binding protein. Vitamin D 74-83 hippocalcin Rattus norvegicus 104-127 3919968-1 1985 A simple method for the quantification of the vitamin D binding capacity (concentration of vitamin D binding protein, DBP) in serum is described. Vitamin D 46-55 GC vitamin D binding protein Homo sapiens 91-116 6387694-8 1984 The kidney hydroxylase responsible for the final hydroxylation of the vitamin D hormone can be further stimulated by in vivo or in vitro administration of estradiol and, to a lesser extent, prolactin and parathyroid hormone. Vitamin D 70-79 prolactin Gallus gallus 190-199 6089793-1 1984 The amount of skin calcium-binding protein, evaluated using a sensitive radioimmunoassay and indirect immunofluorescence, was decreased in vitamin-D deficient rats and increased after one week vitamin D3 or 1 alpha-hydroxyvitamin D3 treatment. Vitamin D 139-148 hippocalcin Rattus norvegicus 19-42 6089793-2 1984 In vitamin D replete and in vitamin D-deficient animals, skin calcium-binding protein was not sensitive to changes in dietary and/or serum calcium concentrations. Vitamin D 28-37 hippocalcin Rattus norvegicus 62-85 6378596-1 1984 A sensitive double antibody RIA has been developed for the 28,000 mol wt rat renal vitamin D-dependent calcium-binding protein. Vitamin D 83-92 hippocalcin Rattus norvegicus 103-126 6378596-5 1984 The concentration of CaBP in the vitamin D-replete rat kidney is 7.3 +/- 1.0 (mean +/- SEM) micrograms/mg protein. Vitamin D 33-42 hippocalcin Rattus norvegicus 21-25 6378596-6 1984 In vitamin D-deficient rats the level of renal CaBP is 2.6 +/- 0.3 micrograms/mg protein. Vitamin D 3-12 hippocalcin Rattus norvegicus 47-51 6608994-5 1984 Both normal and Hyp mice responded to the vitamin D-deficient diet with a fall in serum calcium (p less than 0.01), significantly increased renal 1-OHase, and significantly decreased renal 24-OHase activities. Vitamin D 42-51 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 189-197 6299054-0 1982 Vitamin-D-induced hypercalcaemia and its effect on serum gastrin, gastrin cells and antral gastrin in parathyroidectomized rats. Vitamin D 0-9 gastrin Rattus norvegicus 57-64 6299054-0 1982 Vitamin-D-induced hypercalcaemia and its effect on serum gastrin, gastrin cells and antral gastrin in parathyroidectomized rats. Vitamin D 0-9 gastrin Rattus norvegicus 66-73 6299054-0 1982 Vitamin-D-induced hypercalcaemia and its effect on serum gastrin, gastrin cells and antral gastrin in parathyroidectomized rats. Vitamin D 0-9 gastrin Rattus norvegicus 66-73 6895734-2 1982 Vitamin D action at the molecular level can be studied by analyzing the response in terms of calcium-binding protein (CaBP; Mr congruent to 9000) biosynthesis to exogenous 1,25-dihydroxyvitamin D3 (1,25-(OH)2-D3). Vitamin D 0-9 hippocalcin Rattus norvegicus 93-116 6895734-2 1982 Vitamin D action at the molecular level can be studied by analyzing the response in terms of calcium-binding protein (CaBP; Mr congruent to 9000) biosynthesis to exogenous 1,25-dihydroxyvitamin D3 (1,25-(OH)2-D3). Vitamin D 0-9 hippocalcin Rattus norvegicus 118-122 6895734-3 1982 In vitamin D-replete animals, the CaBP response occurs within 1 h of intraperitoneal injection when the animals have been fed a high-calcium diet (III), but in 7 h if the animals have been fed a low-calcium diet(I). Vitamin D 3-12 hippocalcin Rattus norvegicus 34-38 6895734-5 1982 In vitamin D-deficient animals, exogenous 1,25-(OH)2-D3 evokes a CaBP response that occurs 7-8 h after treatment and is transcriptional in nature. Vitamin D 3-12 hippocalcin Rattus norvegicus 65-69 6895734-7 1982 Peak response times parallel those found with CaBP biosynthesis, i.e., 3 h in cells from vitamin D-replete animals fed diet III, 7 h in cells from vitamin D-replete animals fed diet I, and 12 h in cells from vitamin D-deficient animal. Vitamin D 89-98 hippocalcin Rattus norvegicus 46-50 6947252-5 1981 These results suggest that the known amino acid sequence homology among calmodulin, troponin C, and S100b may be reflected in a similar functional domain present in these proteins but absent in parvalbumin and vitamin D-dependent protein. Vitamin D 210-219 S100 calcium binding protein B Bos taurus 100-105 6263587-11 1981 The CaBP synthesis in placenta and fetal membranes are vitamin D-dependent, and their regulation differs from that of intestinal CaBP. Vitamin D 55-64 hippocalcin Rattus norvegicus 4-8 438610-10 1979 Azotemic osteodystrophy characterized by a raised serum ALP and a prominent bone isoenzyme predicted a good response to vitamin D, and the decrease in serum ALP following vitamin D was the result of a reduction in the bone isoenzyme. Vitamin D 171-180 ATHS Homo sapiens 157-160 139939-0 1977 Renal calcium binding protein in the diabetic and vitamin D-depleted rat. Vitamin D 50-59 hippocalcin Rattus norvegicus 6-29 139939-4 1977 This contrasts markedly with responses of the duodenal protein to the same stimuli: (a) there was marked depression of duodenal calcium binding protein by vitamin D depletion and diabetes; (b) duodenal calcium binding protein was restored by vitamin D treatment of depleted rats. Vitamin D 155-164 hippocalcin Rattus norvegicus 128-151 139939-4 1977 This contrasts markedly with responses of the duodenal protein to the same stimuli: (a) there was marked depression of duodenal calcium binding protein by vitamin D depletion and diabetes; (b) duodenal calcium binding protein was restored by vitamin D treatment of depleted rats. Vitamin D 242-251 hippocalcin Rattus norvegicus 202-225 402385-1 1977 This study reports the development of a specific and sensitive radioimmunoassay and a simple and accurate radial immunodiffusion (RID) assay for the human serum-binding protein for vitamin D and its metabolites (DBP). Vitamin D 181-190 growth hormone receptor Homo sapiens 155-176 31291127-2 2021 The activated form of vitamin D (1 alpha,25-dihydroxyvitamin D) binds to vitamin D receptor which regulates genes that control cell proliferation, differentiation and apoptosis. Vitamin D 22-31 vitamin D receptor Homo sapiens 73-91 33713690-4 2021 Vitamin D and all its metabolites are circulating in blood bound to vitamin D binding protein, (VDBP). Vitamin D 0-9 GC vitamin D binding protein Homo sapiens 68-93 33713690-4 2021 Vitamin D and all its metabolites are circulating in blood bound to vitamin D binding protein, (VDBP). Vitamin D 0-9 GC vitamin D binding protein Homo sapiens 96-100 32627088-1 2021 BACKGROUND: Vitamin D has anticarcinogenic properties and acts through vitamin D receptor (VDR) to carry out its functions. Vitamin D 12-21 vitamin D receptor Homo sapiens 71-89 32627088-1 2021 BACKGROUND: Vitamin D has anticarcinogenic properties and acts through vitamin D receptor (VDR) to carry out its functions. Vitamin D 12-21 vitamin D receptor Homo sapiens 91-94 33882819-3 2021 Seventeen SNPs of vitamin D metabolic pathway genes, including CYP24A1, CYP27A1, CYP27B1, CYP2R1, GC, and DHCR7, were genotyped with improved multiple ligase detection reaction (iMLDR). Vitamin D 18-27 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 63-70 33882819-3 2021 Seventeen SNPs of vitamin D metabolic pathway genes, including CYP24A1, CYP27A1, CYP27B1, CYP2R1, GC, and DHCR7, were genotyped with improved multiple ligase detection reaction (iMLDR). Vitamin D 18-27 7-dehydrocholesterol reductase Homo sapiens 106-111 33879066-7 2021 In subgroup analysis, circulating VDBP was lower in MS patients (Ln-VDBP (mugr/ml): 3.64 +- 0.91 vs. 5.31 +- 0.77, p = 0.0001) even after adjusting for vitamin D levels, body mass index, and taking vitamin D supplement. Vitamin D 152-161 GC vitamin D binding protein Homo sapiens 34-38 33879066-7 2021 In subgroup analysis, circulating VDBP was lower in MS patients (Ln-VDBP (mugr/ml): 3.64 +- 0.91 vs. 5.31 +- 0.77, p = 0.0001) even after adjusting for vitamin D levels, body mass index, and taking vitamin D supplement. Vitamin D 198-207 GC vitamin D binding protein Homo sapiens 34-38 33923969-5 2021 In 54 women (26.3% of all women) with a risk of NTDs, multivitamin supplementation containing folic acid and vitamin D for one month increased folate level (5.8 +- 0.9 to 19.2 +- 4.0 ng/mL, p < 0.0001) and decreased the homocysteine level (8.2 +- 3.1 to 5.8 +- 0.8 nmol/mL, p < 0.0001) to minimize the risk of NTDs in all women, regardless of MTHFR genotype. Vitamin D 109-118 methylenetetrahydrofolate reductase Homo sapiens 343-348 33853949-1 2021 Fibroblast growth factor 23 (FGF23), a hormone generally derived from bone, is important in phosphate and vitamin D homeostasis. Vitamin D 106-115 fibroblast growth factor 23 Mus musculus 0-27 33853949-1 2021 Fibroblast growth factor 23 (FGF23), a hormone generally derived from bone, is important in phosphate and vitamin D homeostasis. Vitamin D 106-115 fibroblast growth factor 23 Mus musculus 29-34 33863283-2 2021 As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity. Vitamin D 3-12 vitamin D receptor Homo sapiens 59-77 33863283-2 2021 As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity. Vitamin D 3-12 vitamin D receptor Homo sapiens 79-82 33863283-2 2021 As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity. Vitamin D 3-12 vitamin D receptor Homo sapiens 85-88 33863283-2 2021 As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity. Vitamin D 3-12 vitamin D receptor Homo sapiens 85-88 33863283-2 2021 As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity. Vitamin D 59-68 vitamin D receptor Homo sapiens 79-82 33863283-2 2021 As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity. Vitamin D 59-68 vitamin D receptor Homo sapiens 85-88 33863283-2 2021 As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity. Vitamin D 59-68 vitamin D receptor Homo sapiens 85-88 33856702-1 2021 Genetic causes of vitamin D-related hypercalcemia are known to involve mutation of 25-hydroxyvitamin D-24-hydroxylase CYP24A1 or the sodium phosphate co-transporter SLC34A1; which result in excessive 1,25-(OH)2 D hormonal action. Vitamin D 18-27 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 118-125 33856702-3 2021 In this case-control study, we used precision vitamin D metabolite profiling based on LC-MS/MS of an expanded range of vitamin D metabolites - to screen German and French cohorts of hypercalcemia patients, to identify patients with altered vitamin D metabolism where involvement of CYP24A1 or SLC34A1 mutation had been ruled out, and possessed normal 25-OH-D3 :24,25-(OH)2 D3 ratios. Vitamin D 46-55 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 282-289 33935807-9 2021 Additionally, VDR knockdown results in decreased mitochondrial oxidative capacity and ATP production, suggesting that vitamin D is crucial for mitochondrial oxidative phosphorylation capacity; an important driver of muscle regeneration. Vitamin D 118-127 vitamin D receptor Homo sapiens 14-17 33927639-8 2021 In cardiac tissue, vitamin D treatment induces an elevation significantly of the mRNA expression of Pgc1-alpha, Mfn-1, and Drp-1 genes (p = 0.001). Vitamin D 19-28 collapsin response mediator protein 1 Mus musculus 123-128 33837680-1 2021 OBJECTIVES: X-linked hypophosphatemic rickets (XLH) is a congenital fibroblast growth factor (FGF)23-related metabolic bone disease that is treated with active vitamin D and phosphate as conventional therapies. Vitamin D 160-169 fibroblast growth factor 23 Homo sapiens 94-100 33845559-18 2021 Vitamin D deficient patients needed a longer duration of hospitalization, more up gradation of antibiotics, PICU admissions, had more CPAP requirement, longer duration of PICU stay and longer duration of CPAP requirements as compared to vitamin D sufficient group. Vitamin D 0-9 centromere protein J Homo sapiens 134-138 33845559-18 2021 Vitamin D deficient patients needed a longer duration of hospitalization, more up gradation of antibiotics, PICU admissions, had more CPAP requirement, longer duration of PICU stay and longer duration of CPAP requirements as compared to vitamin D sufficient group. Vitamin D 0-9 centromere protein J Homo sapiens 204-208 33836827-8 2021 Treatment of hADMSCs with vitamin D plus BPA (0.1 nM) significantly inhibited the induction of PPARgamma, C/EBP beta, C/EBP alpha, and FASN related to adipocyte differentiation and development. Vitamin D 26-35 fatty acid synthase Homo sapiens 135-139 33836827-11 2021 Our findings showed that the expression of VDR, ERbeta, GLUT4, and FABP4 were upregulated through differentiation with the highest concentrations in 0.1 nM vitamin D plus BPA group for VDR, ERbeta, and GLUT4. Vitamin D 156-165 vitamin D receptor Homo sapiens 43-46 33836827-11 2021 Our findings showed that the expression of VDR, ERbeta, GLUT4, and FABP4 were upregulated through differentiation with the highest concentrations in 0.1 nM vitamin D plus BPA group for VDR, ERbeta, and GLUT4. Vitamin D 156-165 vitamin D receptor Homo sapiens 185-188 33832495-2 2021 The authors grouped the patients into two groups according to the vitamin D levels measured at the time of admission into the hospital and reported that lower vitamin D levels are associated with elevated D-dimer and IL-6 levels, low CD4/CD8 ratio and compromised clinical findings with elevated LIPI and SOFA scores. Vitamin D 159-168 CD8a molecule Homo sapiens 238-241 33897704-5 2021 Its etiology is based on the one hand on polymorphisms within genes affecting the vitamin D system, causing susceptibility towards developing low vitamin D responsiveness and autoimmune diseases; on the other hand it is based on a blockade of vitamin D receptor signaling, e.g. through pathogen infections. Vitamin D 82-91 vitamin D receptor Homo sapiens 243-261 33866723-1 2021 OBJECTIVE: To evaluate the vitamin D receptor (VDR) gene polymorphisms and vitamin D levels in inactive hepatitis B virus (HBV) carriers. Vitamin D 27-36 vitamin D receptor Homo sapiens 47-50 33607405-4 2021 As Selberstein et al., has recently discussed the effect of vitamin D deficiency, and the role of vitamin D supplementation in COVID-19 patients [2], I"d believe that vitamin D binding protein (DBP) is maybe also involved. Vitamin D 60-69 GC vitamin D binding protein Homo sapiens 167-192 33607405-4 2021 As Selberstein et al., has recently discussed the effect of vitamin D deficiency, and the role of vitamin D supplementation in COVID-19 patients [2], I"d believe that vitamin D binding protein (DBP) is maybe also involved. Vitamin D 98-107 GC vitamin D binding protein Homo sapiens 167-192 33792238-2 2021 Additionally, FGF23 interacts with vitamin D and parathyroid hormone in a complex metabolic pathway whose detailed mechanisms are still not clear in human physiology and disease. Vitamin D 35-44 fibroblast growth factor 23 Homo sapiens 14-19 33568925-8 2021 Higher FLI scores [OR= 0.77 (0.07), p<0.01] and ALP levels [beta= -0.03 (-0.06, -0.01), p<0.01] associated to lower vitamin D levels. Vitamin D 116-125 ATHS Homo sapiens 48-51 33623633-13 2021 In conclusion, vitamin D deficiency causes eNOS downregulation and oxidative stress, thereby impairing the vascular function and posing an additional risk for microvascular complications in diabetes. Vitamin D 15-24 nitric oxide synthase 3 Rattus norvegicus 43-47 33183376-6 2021 The cerebral vitamin D status depends upon the functionality of genetic variants of Vitamin D Receptor (VDR) and other involved genes. Vitamin D 13-22 vitamin D receptor Homo sapiens 84-102 33183376-6 2021 The cerebral vitamin D status depends upon the functionality of genetic variants of Vitamin D Receptor (VDR) and other involved genes. Vitamin D 13-22 vitamin D receptor Homo sapiens 104-107 33340772-6 2021 Findings from this study suggest the potential of Vitamin D supplementation in lowering the levels of RANKL and related markers/cytokines such as Th17 cell levels, OPG/RANKL ratio and CXCL10 pathway, which may present as a viable nutrition intervention for the management of RA. Vitamin D 50-59 TNF superfamily member 11 Homo sapiens 102-107 33340772-6 2021 Findings from this study suggest the potential of Vitamin D supplementation in lowering the levels of RANKL and related markers/cytokines such as Th17 cell levels, OPG/RANKL ratio and CXCL10 pathway, which may present as a viable nutrition intervention for the management of RA. Vitamin D 50-59 basic transcription factor 3 pseudogene 11 Homo sapiens 164-167 33340772-6 2021 Findings from this study suggest the potential of Vitamin D supplementation in lowering the levels of RANKL and related markers/cytokines such as Th17 cell levels, OPG/RANKL ratio and CXCL10 pathway, which may present as a viable nutrition intervention for the management of RA. Vitamin D 50-59 TNF superfamily member 11 Homo sapiens 168-173 33340772-6 2021 Findings from this study suggest the potential of Vitamin D supplementation in lowering the levels of RANKL and related markers/cytokines such as Th17 cell levels, OPG/RANKL ratio and CXCL10 pathway, which may present as a viable nutrition intervention for the management of RA. Vitamin D 50-59 C-X-C motif chemokine ligand 10 Homo sapiens 184-190 33488605-6 2020 The production of anti-osteoclastogenic cytokines, e.g., IL-4 and IL-10, is promoted by IL-33 and vitamin D, which are stimulators of both regulatory and Th2 cells. Vitamin D 98-107 interleukin 10 Homo sapiens 66-71 33488605-9 2020 Emerging evidence suggests a functional link between vitamin D and the IL-33/ST2 axis, which acts through hormonal influences and immune-mediated effects, as well as cellular and metabolic functions. Vitamin D 53-62 ST2 Homo sapiens 77-80 33435598-7 2021 Furthermore, statistically higher levels of interleukin-22 were observed in the group of children with vitamin D deficiency (p = 0.01), suggesting a proinflammatory alert state. Vitamin D 103-112 interleukin 22 Homo sapiens 44-58 33405236-3 2021 Over the last decades, extensive research has been focused on the identification of the biochemical and molecular pathways that mediate vitamin D-VDR cellular and genomic actions through which vitamin D regulates the expression of target genes and modulates the progression of liver diseases. Vitamin D 136-145 vitamin D receptor Homo sapiens 146-149 33405236-3 2021 Over the last decades, extensive research has been focused on the identification of the biochemical and molecular pathways that mediate vitamin D-VDR cellular and genomic actions through which vitamin D regulates the expression of target genes and modulates the progression of liver diseases. Vitamin D 193-202 vitamin D receptor Homo sapiens 146-149 32503403-9 2021 CONCLUSION: Since vitamin D is capable of regulating the immune homeostasis and decreasing the autoimmune process through its receptor (VDR), it is regarded as a potential target for RA. Vitamin D 18-27 vitamin D receptor Homo sapiens 136-139 33246082-0 2021 Genetic variant of RXR involved in the vitamin D metabolic pathway was linked to HCV infection outcomes among a high-risk Chinese population. Vitamin D 39-48 retinoid X receptor alpha Homo sapiens 19-22 33952739-10 2021 Moreover, serum C-reactive protein (CRP) and interleukin-6 (IL-6) in the vitamin D treatment groups were significantly suppressed by 1,25(OH)2D3 administration compared with the MC group. Vitamin D 73-82 C-reactive protein, pentraxin-related Mus musculus 16-34 33952739-10 2021 Moreover, serum C-reactive protein (CRP) and interleukin-6 (IL-6) in the vitamin D treatment groups were significantly suppressed by 1,25(OH)2D3 administration compared with the MC group. Vitamin D 73-82 C-reactive protein, pentraxin-related Mus musculus 36-39 32287103-3 2021 The pleiotropic effects of vitamin D are exerted via vitamin D receptor (VDR) and its genetic alterations could influence its functions. Vitamin D 27-36 vitamin D receptor Homo sapiens 53-71 32287103-3 2021 The pleiotropic effects of vitamin D are exerted via vitamin D receptor (VDR) and its genetic alterations could influence its functions. Vitamin D 27-36 vitamin D receptor Homo sapiens 73-76 32474936-6 2021 The bioactivity of vitamin D in hPDLCs was assessed based on the gene expression levels of vitamin D receptor (VDR) regulated genes osteocalcin and osteopontin. Vitamin D 19-28 vitamin D receptor Homo sapiens 91-109 32474936-6 2021 The bioactivity of vitamin D in hPDLCs was assessed based on the gene expression levels of vitamin D receptor (VDR) regulated genes osteocalcin and osteopontin. Vitamin D 19-28 vitamin D receptor Homo sapiens 111-114 32270535-0 2021 Maternal Vitamin D Deficiency Increases Intestinal Permeability and Programs Wnt/beta-Catenin Pathway in BALB/C Mice. Vitamin D 9-18 catenin (cadherin associated protein), beta 1 Mus musculus 81-93 32270535-5 2021 RESULTS: Maternal vitamin D deficiency increased intestinal permeability in offspring, which corresponded with the decreased expression of the tight junction protein claudin-1. Vitamin D 18-27 claudin 1 Mus musculus 166-175 32270535-6 2021 Maternal vitamin D deficiency also repressed the messenger RNA expression of wingless/integrated family member 3a (Wnt3a) and the protein expression of nuclear beta-catenin. Vitamin D 9-18 catenin (cadherin associated protein), beta 1 Mus musculus 160-172 32270535-8 2021 The activation of the Wnt/beta-catenin pathway protected against the impairment of intestinal permeability induced by maternal vitamin D deficiency. Vitamin D 127-136 catenin (cadherin associated protein), beta 1 Mus musculus 26-38 33214002-0 2021 Is there an underlying link between COVID-19, ACE2, oxytocin and vitamin D? Vitamin D 65-74 oxytocin/neurophysin I prepropeptide Homo sapiens 52-60 32743932-8 2021 RESULTS: Patients with higher levels of FGF23 were younger and had higher levels of serum albumin, creatinine, albumin-corrected calcium, phosphorus, PTH, 25(OH)-vitamin D, and had higher percentages of intravenous (IV) iron, IV vitamin D and cinacalcet use. Vitamin D 162-171 fibroblast growth factor 23 Homo sapiens 40-45 32743932-8 2021 RESULTS: Patients with higher levels of FGF23 were younger and had higher levels of serum albumin, creatinine, albumin-corrected calcium, phosphorus, PTH, 25(OH)-vitamin D, and had higher percentages of intravenous (IV) iron, IV vitamin D and cinacalcet use. Vitamin D 229-238 fibroblast growth factor 23 Homo sapiens 40-45 33446057-1 2021 Vitamin D (VDR)-mediated signaling contributes to the cell signaling pathways that affect cancer development. Vitamin D 0-9 vitamin D receptor Homo sapiens 11-14 32430147-1 2020 BACKGROUND: Fibroblast growth factor 23 (FGF23), an important regulator of phosphate and vitamin D metabolism, has also been suggested to perform metabolic functions. Vitamin D 89-98 fibroblast growth factor 23 Homo sapiens 12-39 32430147-1 2020 BACKGROUND: Fibroblast growth factor 23 (FGF23), an important regulator of phosphate and vitamin D metabolism, has also been suggested to perform metabolic functions. Vitamin D 89-98 fibroblast growth factor 23 Homo sapiens 41-46 33266022-8 2020 RESULTS: High-dose vitamin D treatment alone and combined with infliximab decreased the IL17A, IFNgamma and IL10 expression. Vitamin D 19-28 interleukin 17A Homo sapiens 88-93 33266022-8 2020 RESULTS: High-dose vitamin D treatment alone and combined with infliximab decreased the IL17A, IFNgamma and IL10 expression. Vitamin D 19-28 interleukin 10 Homo sapiens 108-112 33266022-11 2020 CONCLUSIONS: High-dose vitamin D as monotherapy and combined with infliximab decreases IL17A, IFNgamma and IL-10 expression in mucosa within treatment groups. Vitamin D 23-32 interleukin 17A Homo sapiens 87-92 33266022-11 2020 CONCLUSIONS: High-dose vitamin D as monotherapy and combined with infliximab decreases IL17A, IFNgamma and IL-10 expression in mucosa within treatment groups. Vitamin D 23-32 interleukin 10 Homo sapiens 107-112 33294462-2 2020 Vitamin D levels in DN patients are very low due to the decrease in the synthesis and activity of 1-alpha hydroxylase in the proximal tubule cells and decrease in the vitamin D receptor abundance. Vitamin D 0-9 vitamin D receptor Homo sapiens 167-185 33255834-2 2020 Vitamin D, partly mediated through the vitamin D receptor (VDR), has potential therapeutic applications in skin cancer. Vitamin D 0-9 vitamin D receptor Homo sapiens 39-57 33255834-2 2020 Vitamin D, partly mediated through the vitamin D receptor (VDR), has potential therapeutic applications in skin cancer. Vitamin D 0-9 vitamin D receptor Homo sapiens 59-62 33329593-8 2020 Overall, our data show a crosstalk between vitamin D and CD46 that allows a preferential effect of Vitamin D on Tr1 cells, providing novel key insights into the role of an important modifiable environmental factor in MS. Vitamin D 43-52 thioredoxin reductase 1 Homo sapiens 112-115 33329593-8 2020 Overall, our data show a crosstalk between vitamin D and CD46 that allows a preferential effect of Vitamin D on Tr1 cells, providing novel key insights into the role of an important modifiable environmental factor in MS. Vitamin D 99-108 thioredoxin reductase 1 Homo sapiens 112-115 33228578-1 2020 BACKGROUND: Vitamin D deficiency (VDD) has been related to vitamin D binding protein (GC) gene polymorphism, demographics and lifestyle factors in different populations. Vitamin D 12-21 GC vitamin D binding protein Homo sapiens 59-84 33211721-7 2020 We found that human arteries express a functionally active vitamin D system, including the VDR, 1alpha-hydroxylase and 24-hydroxylase (24-OHase) components and these were dysregulated in CKD arteries. Vitamin D 59-68 vitamin D receptor Homo sapiens 91-94 33211721-7 2020 We found that human arteries express a functionally active vitamin D system, including the VDR, 1alpha-hydroxylase and 24-hydroxylase (24-OHase) components and these were dysregulated in CKD arteries. Vitamin D 59-68 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 135-143 33202670-6 2020 Vitamin D and its receptor vitamin D receptor (VDR) exert a critical role in infections due to their remarkable impact on both innate and adaptive immune responses and on the suppression of the inflammatory process. Vitamin D 0-9 vitamin D receptor Homo sapiens 27-45 33202670-6 2020 Vitamin D and its receptor vitamin D receptor (VDR) exert a critical role in infections due to their remarkable impact on both innate and adaptive immune responses and on the suppression of the inflammatory process. Vitamin D 0-9 vitamin D receptor Homo sapiens 47-50 33186385-2 2020 Vitamin D action takes place through vitamin D receptor (VDR) activation. Vitamin D 0-9 vitamin D receptor Homo sapiens 37-55 33186385-2 2020 Vitamin D action takes place through vitamin D receptor (VDR) activation. Vitamin D 0-9 vitamin D receptor Homo sapiens 57-60 33186385-11 2020 CONCLUSIONS: Despite being preliminary, these findings suggest that genotyping of pregnant women for VDR polymorphisms may be useful for a tailored vitamin D supplementation strategy. Vitamin D 148-157 vitamin D receptor Homo sapiens 101-104 32942038-3 2020 Vitamin D is a pleiotropic hormone that executes its actions on cells through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 82-100 32942038-3 2020 Vitamin D is a pleiotropic hormone that executes its actions on cells through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 102-105 32942038-7 2020 Further, intestinal VDR expression is inversely correlated with the severity of inflammation in patients with IBD, which might compromise the positive effects of vitamin D signaling in patients with flaring disease. Vitamin D 162-171 vitamin D receptor Homo sapiens 20-23 33131491-2 2020 We hypothesized that vitamin D intake should refer to vitamin D receptor (VDR) expression. Vitamin D 21-30 vitamin D receptor Homo sapiens 54-72 33131491-2 2020 We hypothesized that vitamin D intake should refer to vitamin D receptor (VDR) expression. Vitamin D 21-30 vitamin D receptor Homo sapiens 74-77 33131491-15 2020 It is expected that a more individualized vitamin D intake and a more accurate prognosis assessment can be recommended for BC patients based on the VDR expression. Vitamin D 42-51 vitamin D receptor Homo sapiens 148-151 33275093-0 2020 Vitamin D increases the production of IL-10 by regulatory T cells in patients with systemic sclerosis. Vitamin D 0-9 interleukin 10 Homo sapiens 38-43 32964520-1 2020 Fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH) are regulators of renal phosphate excretion and vitamin D metabolism. Vitamin D 114-123 fibroblast growth factor 23 Homo sapiens 0-27 32964520-1 2020 Fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH) are regulators of renal phosphate excretion and vitamin D metabolism. Vitamin D 114-123 fibroblast growth factor 23 Homo sapiens 29-34 33037402-5 2020 Differential methylation of Vitamin D Receptor binding sites and MS risk genes was assessed from this and using pyrosequencing for the vitamin D regulated MS risk gene ZMIZ1. Vitamin D 135-144 vitamin D receptor Homo sapiens 28-46 32529210-11 2020 Vitamin D status was misclassified in 7 samples by the Roche assay and 3 by the IDS assay. Vitamin D 0-9 iduronate 2-sulfatase Homo sapiens 80-83 33289915-5 2020 Loss-of-function mutations in the genes CYP24A1 and SLC34A1, involved in vitamin D metabolism leading to hypercalcemia could not be found in this patient. Vitamin D 73-82 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 40-47 32737774-4 2020 In this study, we examined the association of vitamin D status with high mobility group box 1 (HMGB1)-mediated pathways (HMGB1, receptor for advanced glycation end products [RAGE], and Toll-like receptor-2 and -4 [TLR2 and TLR4]) in neointimal hyperplasia in atherosclerotic swine following bare metal stenting. Vitamin D 46-55 TLR2 Sus scrofa 214-218 33000217-0 2020 Vitamin D receptor knockdown attenuates the antiproliferative, pro-apoptotic and anti-invasive effect of vitamin D by activating the Wnt/beta-catenin signaling pathway in papillary thyroid cancer. Vitamin D 105-114 vitamin D receptor Homo sapiens 0-18 33000217-3 2020 Therefore, the present study aimed to determine the role of the VDR and its association with Wnt/beta-catenin signaling in vitamin D-treated PTC cells. Vitamin D 123-132 vitamin D receptor Homo sapiens 64-67 33000217-11 2020 In conclusion, the present study revealed that VDR-KD attenuated the antiproliferative, pro-apoptotic and anti-invasive effects of vitamin D in PTC by activating the Wnt/beta-catenin signaling pathway. Vitamin D 131-140 vitamin D receptor Homo sapiens 47-50 32940108-3 2020 Vitamin D binding protein (VDBP) has important functions, including transporting vitamin D and its metabolites to target cells. Vitamin D 81-90 GC vitamin D binding protein Homo sapiens 0-25 32940108-3 2020 Vitamin D binding protein (VDBP) has important functions, including transporting vitamin D and its metabolites to target cells. Vitamin D 81-90 GC vitamin D binding protein Homo sapiens 27-31 33413767-12 2020 CONCLUSION: The vitamin D-binding protein gene rs2282679 was significantly associated with serum vitamin D insufficiency and deficiency in college students, and A-allele is a risk factor accounting for vitamin D insufficiency and deficiency in college students. Vitamin D 97-106 GC vitamin D binding protein Homo sapiens 16-41 33126642-0 2020 Pirfenidone and Vitamin D Ameliorate Cardiac Fibrosis Induced by Doxorubicin in Ehrlich Ascites Carcinoma Bearing Mice: Modulation of Monocyte Chemoattractant Protein-1 and Jun N-terminal Kinase-1 Pathways. Vitamin D 16-25 chemokine (C-C motif) ligand 2 Mus musculus 134-168 33126642-0 2020 Pirfenidone and Vitamin D Ameliorate Cardiac Fibrosis Induced by Doxorubicin in Ehrlich Ascites Carcinoma Bearing Mice: Modulation of Monocyte Chemoattractant Protein-1 and Jun N-terminal Kinase-1 Pathways. Vitamin D 16-25 mitogen-activated protein kinase 8 Mus musculus 173-196 33126642-11 2020 Current data demonstrate that pirfenidone and vitamin D represent an attractive approach to ameliorate the cardiac fibrosis produced by doxorubicin through inhibiting both JNK1 signaling and MCP-1 inflammatory pathways, thus preserving heart function. Vitamin D 46-55 mitogen-activated protein kinase 8 Mus musculus 172-176 33126642-11 2020 Current data demonstrate that pirfenidone and vitamin D represent an attractive approach to ameliorate the cardiac fibrosis produced by doxorubicin through inhibiting both JNK1 signaling and MCP-1 inflammatory pathways, thus preserving heart function. Vitamin D 46-55 chemokine (C-C motif) ligand 2 Mus musculus 191-196 33091918-3 2021 Vitamin D has an immune-regulatory role and suppresses IL-17 production via direct transcriptional inhibition of IL-17 gene expression. Vitamin D 0-9 interleukin 17A Homo sapiens 55-60 33091918-3 2021 Vitamin D has an immune-regulatory role and suppresses IL-17 production via direct transcriptional inhibition of IL-17 gene expression. Vitamin D 0-9 interleukin 17A Homo sapiens 113-118 33091918-4 2021 OBJECTIVE: To explore the relationship of IL-17 and vitamin D levels with LP, and the possible inter-relationship between IL-17 and vitamin D. Vitamin D 52-61 interleukin 17A Homo sapiens 42-47 33091918-12 2021 However, a direct relationship between IL-17 and vitamin D deficiency could not be clarified. Vitamin D 49-58 interleukin 17A Homo sapiens 39-44 33105665-2 2020 Because of the very short half-life of free serum vitamin D it is stabilized and transported to target tissues by being bound to the vitamin D binding protein (VDBP). Vitamin D 50-59 GC vitamin D binding protein Homo sapiens 133-158 33105665-2 2020 Because of the very short half-life of free serum vitamin D it is stabilized and transported to target tissues by being bound to the vitamin D binding protein (VDBP). Vitamin D 50-59 GC vitamin D binding protein Homo sapiens 160-164 33084400-2 2020 Vitamin D receptor (VDR) is abundantly expressed in the distal region of small intestine, where the Paneth cells are enriched, suggesting that vitamin D signaling may modulates the intestinal Paneth cells and their production of defensins to restrain microbiome growth in the small intestine. Vitamin D 143-152 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 0-18 33084400-2 2020 Vitamin D receptor (VDR) is abundantly expressed in the distal region of small intestine, where the Paneth cells are enriched, suggesting that vitamin D signaling may modulates the intestinal Paneth cells and their production of defensins to restrain microbiome growth in the small intestine. Vitamin D 143-152 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 20-23 33043047-2 2020 Data regarding the effect of vitamin D on elastin degradation are lacking. Vitamin D 29-38 elastin Homo sapiens 42-49 33043047-3 2020 Based on the vitamin"s anti-inflammatory properties, we hypothesised that vitamin D supplementation reduces elastin degradation, particularly in vitamin D-deficient COPD patients. Vitamin D 74-83 elastin Homo sapiens 108-115 33043047-4 2020 We assessed the effect of vitamin D status and supplementation on elastin degradation by measuring plasma desmosine, a biomarker of elastin degradation. Vitamin D 26-35 elastin Homo sapiens 66-73 33043047-10 2020 Contrary to our hypothesis, the intervention decelerated elastin degradation in vitamin D-sufficient COPD patients and not in vitamin D-deficient subjects. Vitamin D 80-89 elastin Homo sapiens 57-64 32900990-7 2020 Chromatin immunoprecipitation (ChIP) and assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) analyses showed that VDR transcriptionally repressed SRY-box 2 (SOX2) by binding to the vitamin D response elements in the promoter of SOX2, impairing tumor growth and drug resistance. Vitamin D 215-224 vitamin D receptor Homo sapiens 148-151 32900990-7 2020 Chromatin immunoprecipitation (ChIP) and assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) analyses showed that VDR transcriptionally repressed SRY-box 2 (SOX2) by binding to the vitamin D response elements in the promoter of SOX2, impairing tumor growth and drug resistance. Vitamin D 215-224 SRY-box transcription factor 2 Homo sapiens 180-189 32900990-7 2020 Chromatin immunoprecipitation (ChIP) and assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) analyses showed that VDR transcriptionally repressed SRY-box 2 (SOX2) by binding to the vitamin D response elements in the promoter of SOX2, impairing tumor growth and drug resistance. Vitamin D 215-224 SRY-box transcription factor 2 Homo sapiens 191-195 32900990-9 2020 These findings reveal a new mechanism by which acidosis could affect the stemness of CRC cells by regulating the expression of SOX2 and show that abnormal VDR expression leads to ineffective activation of vitamin D signaling, resulting in a lack of efficacy of vitamin D in antineoplastic process. Vitamin D 205-214 vitamin D receptor Homo sapiens 155-158 32900990-9 2020 These findings reveal a new mechanism by which acidosis could affect the stemness of CRC cells by regulating the expression of SOX2 and show that abnormal VDR expression leads to ineffective activation of vitamin D signaling, resulting in a lack of efficacy of vitamin D in antineoplastic process. Vitamin D 261-270 vitamin D receptor Homo sapiens 155-158 32911690-6 2020 Interestingly, the increased IL-18 only decreased by vitamin D addition in endothelial cells but not in RPE cells, suggesting a main antiangiogenic role under inflammatory conditions. Vitamin D 53-62 interleukin 18 Homo sapiens 29-34 32911795-2 2020 Recently, new and interesting aspects of vitamin D metabolism has been elucidated, namely the special role of the skin, the metabolic control of liver hydroxylase CYP2R1, the specificity of 1alpha-hydroxylase in different tissues and cell types and the genomic, non-genomic and epigenomic effects of vitamin D receptor, which will be addressed in the present review. Vitamin D 41-50 vitamin D receptor Homo sapiens 300-318 32899460-2 2020 The depletion of vitamin D seems to play a role in the fragilization of old persons, and genetic polymorphisms of the vitamin D receptor (VDR) gene seem to be involved in regulating the vitamin D pathway. Vitamin D 118-127 vitamin D receptor Homo sapiens 138-141 32899880-3 2020 However, the observation of seasonal changes in blood pressure and the subsequent identification of vitamin D receptor (VDR) and 1alpha-hydroxylase in cardiomyocytes, as well as endothelial and vascular smooth muscle cells, implicated a role of vitamin D in the cardiovascular system. Vitamin D 100-109 vitamin D receptor Homo sapiens 120-123 32673820-7 2020 The AMP levels of GCF and gingival tissue in the vitamin D deficient group was lower compared to sufficient serum 25(OH)D within gingivitis and CP groups. Vitamin D 49-58 guanylate cyclase 2F, retinal Homo sapiens 18-21 32673820-9 2020 Regression analysis showed that the periodontal disease status, serum vitamin D concentration were independent predictors for elevated GCF AMP levels. Vitamin D 70-79 guanylate cyclase 2F, retinal Homo sapiens 135-138 32986367-1 2020 BACKGROUND: Vitamin D inhibits cell proliferation via the vitamin D receptor (VDR), which may affect breast cancer risk. Vitamin D 12-21 vitamin D receptor Homo sapiens 58-76 32986367-1 2020 BACKGROUND: Vitamin D inhibits cell proliferation via the vitamin D receptor (VDR), which may affect breast cancer risk. Vitamin D 12-21 vitamin D receptor Homo sapiens 78-81 32516167-2 2020 The aim of the current study was to evaluate the functional impact of the genetic polymorphism rs2762939 of CYP24A1, the hydroxylase-enzyme modulating the inactivation of vitamin D, on the prevalence and extent of coronary artery disease (CAD).A consecutive cohort of patients undergoing coronary angiography in a single centre was included. Vitamin D 171-180 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 108-115 31810868-10 2020 CONCLUSION: Collectively, the evidences from this study demonstrated that active VD could alleviate the development of NAFLD through blocking the p53-p21 signaling pathway, which provided a novel nutritional therapeutic insight for NAFLD. Vitamin D 81-83 KRAS proto-oncogene, GTPase Rattus norvegicus 150-153 32701599-2 2020 Study of inherited and acquired hypophosphatemic syndromes led to the discovery of fibroblast growth factor 23 (FGF23) as a potent regulator of phosphate and vitamin D metabolism, and advanced our understanding of the pathophysiology of mineral and bone disorder in chronic kidney disease (CKD-MBD). Vitamin D 158-167 fibroblast growth factor 23 Homo sapiens 83-110 32701599-2 2020 Study of inherited and acquired hypophosphatemic syndromes led to the discovery of fibroblast growth factor 23 (FGF23) as a potent regulator of phosphate and vitamin D metabolism, and advanced our understanding of the pathophysiology of mineral and bone disorder in chronic kidney disease (CKD-MBD). Vitamin D 158-167 fibroblast growth factor 23 Homo sapiens 112-117 31232112-9 2020 CONCLUSION: It is known that active vitamin D inhibits the growth of cancer cells by binding to vitamin D receptor with regulation of genes responsible for cell proliferation. Vitamin D 36-45 vitamin D receptor Homo sapiens 96-114 32379895-2 2020 The action of calcitriol, the active metabolite of vitamin D, is mediated by the vitamin D receptor (VDR) that is present in most tissues. Vitamin D 51-60 vitamin D receptor Homo sapiens 81-99 32379895-2 2020 The action of calcitriol, the active metabolite of vitamin D, is mediated by the vitamin D receptor (VDR) that is present in most tissues. Vitamin D 51-60 vitamin D receptor Homo sapiens 101-104 32379895-13 2020 New vitamin D treatment studies that examine CRC should take in account confounding factors such as obesity or VDR genotypes. Vitamin D 4-13 vitamin D receptor Homo sapiens 111-114 32654294-1 2020 The genomic actions of the vitamin D are mediated via its biologically most potent metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2 D3 ) and the transcription factor vitamin D receptor (VDR). Vitamin D 27-36 vitamin D receptor Homo sapiens 169-187 32654294-1 2020 The genomic actions of the vitamin D are mediated via its biologically most potent metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2 D3 ) and the transcription factor vitamin D receptor (VDR). Vitamin D 27-36 vitamin D receptor Homo sapiens 189-192 32654294-7 2020 Furthermore, also VDR seems to play a role in membrane-based responses to vitamin D. Vitamin D 74-83 vitamin D receptor Homo sapiens 18-21 32729975-2 2020 Here, we demonstrate systemic and direct effects of Fibroblast growth factor 23 (FGF23) and Klotho, which normally regulate vitamin D and mineral homeostasis, on testicular function. Vitamin D 124-133 fibroblast growth factor 23 Homo sapiens 52-79 32729975-2 2020 Here, we demonstrate systemic and direct effects of Fibroblast growth factor 23 (FGF23) and Klotho, which normally regulate vitamin D and mineral homeostasis, on testicular function. Vitamin D 124-133 fibroblast growth factor 23 Homo sapiens 81-86 32729975-2 2020 Here, we demonstrate systemic and direct effects of Fibroblast growth factor 23 (FGF23) and Klotho, which normally regulate vitamin D and mineral homeostasis, on testicular function. Vitamin D 124-133 klotho Homo sapiens 92-98 32729975-10 2020 In conclusion, this translational study suggests that FGF23 and Klotho influence gonadal function and testicular mineral ion homeostasis both directly and indirectly through systemic changes in vitamin D and mineral homeostasis. Vitamin D 194-203 fibroblast growth factor 23 Homo sapiens 54-59 32729975-10 2020 In conclusion, this translational study suggests that FGF23 and Klotho influence gonadal function and testicular mineral ion homeostasis both directly and indirectly through systemic changes in vitamin D and mineral homeostasis. Vitamin D 194-203 klotho Homo sapiens 64-70 32479918-11 2020 Interestingly, vitamin D supplementation improved the mitochondrial cristae shape by regulating the expression of mitofusin-1/2 (MFN1/2), optic atrophy 1 (OPA1) and dynamin-related protein 1 (Drp1). Vitamin D 15-24 OPA1, mitochondrial dynamin like GTPase Mus musculus 138-153 32479918-11 2020 Interestingly, vitamin D supplementation improved the mitochondrial cristae shape by regulating the expression of mitofusin-1/2 (MFN1/2), optic atrophy 1 (OPA1) and dynamin-related protein 1 (Drp1). Vitamin D 15-24 OPA1, mitochondrial dynamin like GTPase Mus musculus 155-159 32823606-10 2020 This first randomized controlled trial of supplementation with multiple micronutrients and DHA in pregnant women indicated that MMS significantly improved maternal DHA and vitamin D status in an industrialized setting-an important finding considering the essential roles of DHA and vitamin D. Vitamin D 172-181 MMS Homo sapiens 128-131 32823606-10 2020 This first randomized controlled trial of supplementation with multiple micronutrients and DHA in pregnant women indicated that MMS significantly improved maternal DHA and vitamin D status in an industrialized setting-an important finding considering the essential roles of DHA and vitamin D. Vitamin D 282-291 MMS Homo sapiens 128-131 32829285-1 2020 Transient receptor potential vanilloid 6 (TRPV6), a calcium-selective channel possessing six transmembrane domains (S1-S6) and intracellular N and C termini, plays crucial roles in calcium absorption in epithelia and bone and is involved in human diseases including vitamin-D deficiency, osteoporosis, and cancer. Vitamin D 266-275 transient receptor potential cation channel subfamily V member 6 Homo sapiens 0-40 32829285-1 2020 Transient receptor potential vanilloid 6 (TRPV6), a calcium-selective channel possessing six transmembrane domains (S1-S6) and intracellular N and C termini, plays crucial roles in calcium absorption in epithelia and bone and is involved in human diseases including vitamin-D deficiency, osteoporosis, and cancer. Vitamin D 266-275 transient receptor potential cation channel subfamily V member 6 Homo sapiens 42-47 32764491-8 2020 These results suggest a cumulative effect of SNPs at the DHCR7, GC, CYP2R1 and CYP24A1 loci on the susceptibility to type 1 diabetes, due to the roles of these genes in the vitamin D metabolic pathway. Vitamin D 173-182 7-dehydrocholesterol reductase Homo sapiens 57-62 32764491-8 2020 These results suggest a cumulative effect of SNPs at the DHCR7, GC, CYP2R1 and CYP24A1 loci on the susceptibility to type 1 diabetes, due to the roles of these genes in the vitamin D metabolic pathway. Vitamin D 173-182 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 79-86 32408752-6 2020 Furthermore, the significant negative correlation between vitamin D level and CD8+ cell percentage, PLT, CRP and D-dimers was seen. Vitamin D 58-67 CD8a molecule Homo sapiens 78-81 32628073-10 2020 Our findings suggest that 25OHD-Gluc, a vitamin D metabolite found in bile, induces VDR-mediated responses in the colon by crossing the apical membrane of the colon epithelium. Vitamin D 40-49 vitamin D receptor Homo sapiens 84-87 32712621-10 2020 Vitamin D could decrease ROS level, apoptotic neuron cells and DUOX1 expression, and increase VDR expression. Vitamin D 0-9 dual oxidase 1 Canis lupus familiaris 63-68 32717927-4 2020 A high concentration of active vitamin D, 1alpha,25(OH)2D3, decreased the expression of myogenic regulatory factors (MRFs), myf5 and myogenin in proliferating myoblasts. Vitamin D 31-40 myogenic factor 5 Homo sapiens 124-128 32686744-0 2020 The impact of vitamin D supplementation on VDR gene expression and body composition in monozygotic twins: randomized controlled trial. Vitamin D 14-23 vitamin D receptor Homo sapiens 43-46 32686744-4 2020 The objective of this randomised controlled study is to examine the effect of vitamin D supplementation on body composition and the expression of the vitamin D receptor (VDR) mRNA. Vitamin D 78-87 vitamin D receptor Homo sapiens 170-173 32664376-1 2020 BACKGROUND: Vitamin D-binding protein (VDBP) has been implicated in several adverse pregnancy outcomes either directly or indirectly via influencing the concentrations of biologically active vitamin D metabolites. Vitamin D 191-200 GC vitamin D binding protein Homo sapiens 12-37 32664376-1 2020 BACKGROUND: Vitamin D-binding protein (VDBP) has been implicated in several adverse pregnancy outcomes either directly or indirectly via influencing the concentrations of biologically active vitamin D metabolites. Vitamin D 191-200 GC vitamin D binding protein Homo sapiens 39-43 32635656-1 2020 Vitamin D is a fat-soluble vitamin that is metabolized by the liver into 25-hydroxyvitamin D [25(OH)D] and then by the kidney into 1,25-dihydroxyvitamin D [1,25(OH)2D], which activates the vitamin D receptor expressed in various cells, including immune cells, for an overall immunostimulatory effect. Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 189-207 32775008-0 2020 Variants in SNAI1, AMDHD1 and CUBN in vitamin D pathway genes are associated with breast cancer risk: a large-scale analysis of 14 GWASs in the DRIVE study. Vitamin D 38-47 cubilin Homo sapiens 30-34 32323557-9 2020 There was an increase in serum levels of IL-10 after 3 days from vitamin D treatment before surgery (vitamin D group = 4.4 +- 4.9 ng/mL and control group = 1 +- 0.5 ng/mL, P = .001). Vitamin D 65-74 interleukin 10 Homo sapiens 41-46 32323557-9 2020 There was an increase in serum levels of IL-10 after 3 days from vitamin D treatment before surgery (vitamin D group = 4.4 +- 4.9 ng/mL and control group = 1 +- 0.5 ng/mL, P = .001). Vitamin D 101-110 interleukin 10 Homo sapiens 41-46 32323557-10 2020 After operation, IL-10 increased in both groups, higher level in vitamin D group (P < .001). Vitamin D 65-74 interleukin 10 Homo sapiens 17-22 31907821-0 2020 Association between vitamin D deficiency and common variants of Vitamin D binding protein gene among Mexican Mestizo and indigenous postmenopausal women. Vitamin D 20-29 GC vitamin D binding protein Homo sapiens 64-89 32670515-3 2020 Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia. Vitamin D 6-15 GC vitamin D binding protein Homo sapiens 33-37 32670515-3 2020 Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia. Vitamin D 6-15 vitamin D receptor Homo sapiens 93-111 32670515-3 2020 Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia. Vitamin D 6-15 vitamin D receptor Homo sapiens 113-116 32670515-3 2020 Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia. Vitamin D 6-15 retinoid X receptor alpha Homo sapiens 118-143 32670515-3 2020 Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia. Vitamin D 6-15 retinoid X receptor alpha Homo sapiens 145-149 32670515-3 2020 Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia. Vitamin D 68-77 GC vitamin D binding protein Homo sapiens 6-31 32670515-3 2020 Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia. Vitamin D 68-77 GC vitamin D binding protein Homo sapiens 33-37 32670515-3 2020 Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia. Vitamin D 68-77 vitamin D receptor Homo sapiens 93-111 32670515-3 2020 Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia. Vitamin D 68-77 vitamin D receptor Homo sapiens 113-116 32670515-3 2020 Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia. Vitamin D 68-77 retinoid X receptor alpha Homo sapiens 118-143 32670515-3 2020 Since vitamin D binding protein (VDBP) maintains bioavailability of vitamin D which binds to vitamin D receptor (VDR)-retinoid X receptor alpha (RXRA) heterodimer to exert its molecular actions, we speculated that vitamin D metabolic-axis expression signature and variants could be potential molecular candidates for bone turnover/disease in thalassemia. Vitamin D 68-77 retinoid X receptor alpha Homo sapiens 145-149 32670515-14 2020 VDBP rs4701 variant was associated with osteoporosis in our beta-thalassemia patients on vitamin D supplementation. Vitamin D 89-98 GC vitamin D binding protein Homo sapiens 0-4 32464532-11 2020 CONCLUSIONS: Our results suggest that GC-rs4588 is associated with lower serum 25(OH)D concentration in both Malaysian CWE and healthy children, while VDR-rs7975232A is associated with lower risk of vitamin D deficiency in Malaysian CWE of Malay ethnicity. Vitamin D 199-208 vitamin D receptor Homo sapiens 151-154 32655262-5 2020 Fibroblast growth factor 23 (FGF-23) is a strong antagonist of vitamin D action. Vitamin D 63-72 fibroblast growth factor 23 Homo sapiens 0-27 32655262-5 2020 Fibroblast growth factor 23 (FGF-23) is a strong antagonist of vitamin D action. Vitamin D 63-72 fibroblast growth factor 23 Homo sapiens 29-35 32452516-0 2020 Vitamin D-vitamin D receptor system downregulates expression of uncoupling proteins in brown adipocyte through interaction with hairless protein. Vitamin D 0-9 HR, lysine demethylase and nuclear receptor corepressor Rattus norvegicus 128-144 32884689-12 2020 Variants of GC (rs1155563) and CYP24A1 (rs6013897) were significantly associated with both 25(OH)D concentrations and vitamin D deficiency among pregnant women, respectively. Vitamin D 118-127 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 31-38 32884689-14 2020 Genetic mutants in the vitamin D pathway (GC and CYP24A1) were significantly associated with 25(OH)D levels in pregnant women in Eastern and Central China. Vitamin D 23-32 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 49-56 32626760-1 2020 Vitamin D and its cognate intracellular nuclear receptor, namely, vitamin D receptor (VDR), are involved in the regulation of a variety of body metabolic processes, immune function, and oncogenesis. Vitamin D 0-9 vitamin D receptor Homo sapiens 66-84 32626760-1 2020 Vitamin D and its cognate intracellular nuclear receptor, namely, vitamin D receptor (VDR), are involved in the regulation of a variety of body metabolic processes, immune function, and oncogenesis. Vitamin D 0-9 vitamin D receptor Homo sapiens 86-89 32462983-2 2021 Vitamin D receptor (VDR) is a part of the nuclear receptor family exerts vitamin D activation to maintain calcium/phosphorous homeostasis and bone metabolism. Vitamin D 73-82 vitamin D receptor Homo sapiens 0-18 32462983-2 2021 Vitamin D receptor (VDR) is a part of the nuclear receptor family exerts vitamin D activation to maintain calcium/phosphorous homeostasis and bone metabolism. Vitamin D 73-82 vitamin D receptor Homo sapiens 20-23 32462983-3 2021 The reduction of VDR activity leads to vitamin D deficiency. Vitamin D 39-48 vitamin D receptor Homo sapiens 17-20 31961707-0 2020 TGF-beta1 promotes vitamin D-induced prostaglandin E2 synthesis by upregulating vitamin D receptor expression in human granulosa-lutein cells. Vitamin D 19-28 vitamin D receptor Homo sapiens 80-98 31961707-1 2020 There is increasing evidence showing the importance of vitamin D (Vit D) and its nuclear receptor, the Vit D receptor (VDR), in female reproductive health. Vitamin D 55-64 vitamin D receptor Homo sapiens 103-117 31961707-1 2020 There is increasing evidence showing the importance of vitamin D (Vit D) and its nuclear receptor, the Vit D receptor (VDR), in female reproductive health. Vitamin D 55-64 vitamin D receptor Homo sapiens 119-122 31961707-7 2020 Our findings indicate that TGF-beta1 upregulates the expression of VDR, which promotes Vit D-induced COX-2 expression and subsequent PGE2 production by activating the SMAD3 and ERK1/2 signaling pathways in hGL cells. Vitamin D 87-92 vitamin D receptor Homo sapiens 67-70 32157737-3 2020 FGF23 is a hormone controlling renal phosphate and vitamin D metabolism. Vitamin D 51-60 fibroblast growth factor 23 Mus musculus 0-5 31506976-7 2020 Under the chronic inflammation conditions of the DIO model, VDR activation by the vitamin D analog calcipotriol reduced liver inflammation and hepatic steatosis, significantly improving insulin sensitivity. Vitamin D 82-91 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 60-63 31506976-11 2020 Conclusion: Activation of liver macrophage VDR by vitamin D ligands ameliorates liver inflammation, steatosis and insulin resistance. Vitamin D 50-59 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 43-46 32276660-10 2020 While vitamin D administrations delayed fibrosis of early stages, vitamin D worsen hepatic-fibrosis of late stages of CCl4. Vitamin D 66-75 chemokine (C-C motif) ligand 4 Mus musculus 118-122 32276660-13 2020 CONCLUSION: Vitamin D alleviate liver NK cytotoxicity in acute but not in chronic fibrosis model due to modulations in vitamin D receptor and calcium. Vitamin D 12-21 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 119-137 32647755-6 2020 There are other subtypes of rickets, such as vitamin D-dependent type 1 rickets and vitamin D-dependent type 2 rickets (due to defects in vitamin D metabolism), renal rickets (due to poor kidney function), and hypophosphatemic rickets (vitamin D-resistant rickets secondary to renal phosphate wasting wherein fibroblast growth factor-23 (FGF-23) often plays a major role), which requires closer monitoring and supplementation with activated vitamin D with or without phosphate supplements. Vitamin D 84-93 fibroblast growth factor 23 Homo sapiens 309-336 32647755-6 2020 There are other subtypes of rickets, such as vitamin D-dependent type 1 rickets and vitamin D-dependent type 2 rickets (due to defects in vitamin D metabolism), renal rickets (due to poor kidney function), and hypophosphatemic rickets (vitamin D-resistant rickets secondary to renal phosphate wasting wherein fibroblast growth factor-23 (FGF-23) often plays a major role), which requires closer monitoring and supplementation with activated vitamin D with or without phosphate supplements. Vitamin D 84-93 fibroblast growth factor 23 Homo sapiens 338-344 32647755-6 2020 There are other subtypes of rickets, such as vitamin D-dependent type 1 rickets and vitamin D-dependent type 2 rickets (due to defects in vitamin D metabolism), renal rickets (due to poor kidney function), and hypophosphatemic rickets (vitamin D-resistant rickets secondary to renal phosphate wasting wherein fibroblast growth factor-23 (FGF-23) often plays a major role), which requires closer monitoring and supplementation with activated vitamin D with or without phosphate supplements. Vitamin D 84-93 fibroblast growth factor 23 Homo sapiens 309-336 32647755-6 2020 There are other subtypes of rickets, such as vitamin D-dependent type 1 rickets and vitamin D-dependent type 2 rickets (due to defects in vitamin D metabolism), renal rickets (due to poor kidney function), and hypophosphatemic rickets (vitamin D-resistant rickets secondary to renal phosphate wasting wherein fibroblast growth factor-23 (FGF-23) often plays a major role), which requires closer monitoring and supplementation with activated vitamin D with or without phosphate supplements. Vitamin D 84-93 fibroblast growth factor 23 Homo sapiens 338-344 33029248-1 2020 Context: Vitamin D is a steroid hormone that acts by binding to the vitamin D receptor (VDR) found in many tissues. Vitamin D 9-18 vitamin D receptor Homo sapiens 68-86 33029248-1 2020 Context: Vitamin D is a steroid hormone that acts by binding to the vitamin D receptor (VDR) found in many tissues. Vitamin D 9-18 vitamin D receptor Homo sapiens 88-91 32233807-6 2020 Administration of vitamin D to diabetic rats resulted in a decrease of serum glucose, serum ADMA, a decrease of aortic MDA levels, ET-1 and iNOS activity, an increase of aortic SOD activity, NO levels, and cNOS activity. Vitamin D 18-27 nitric oxide synthase 3 Rattus norvegicus 206-210 32355520-1 2020 To clarify the regulation of astragalus on the aging BMSCs model and the effect of astragalus on Vitamin D (VD)-FGF23-Klotho axis. Vitamin D 97-106 fibroblast growth factor 23 Homo sapiens 112-117 32355520-1 2020 To clarify the regulation of astragalus on the aging BMSCs model and the effect of astragalus on Vitamin D (VD)-FGF23-Klotho axis. Vitamin D 97-106 klotho Homo sapiens 118-124 31686401-1 2020 PURPOSE: Turner syndrome (TS) patients display considerable immune misregulation, and it is hypothesized that Vitamin D (VTD) activity may fluctuate according to Vitamin D receptor (VDR) polymorphisms and/or expression profile. Vitamin D 110-119 vitamin D receptor Homo sapiens 162-180 31686401-1 2020 PURPOSE: Turner syndrome (TS) patients display considerable immune misregulation, and it is hypothesized that Vitamin D (VTD) activity may fluctuate according to Vitamin D receptor (VDR) polymorphisms and/or expression profile. Vitamin D 110-119 vitamin D receptor Homo sapiens 182-185 31686401-1 2020 PURPOSE: Turner syndrome (TS) patients display considerable immune misregulation, and it is hypothesized that Vitamin D (VTD) activity may fluctuate according to Vitamin D receptor (VDR) polymorphisms and/or expression profile. Vitamin D 121-124 vitamin D receptor Homo sapiens 162-180 31686401-1 2020 PURPOSE: Turner syndrome (TS) patients display considerable immune misregulation, and it is hypothesized that Vitamin D (VTD) activity may fluctuate according to Vitamin D receptor (VDR) polymorphisms and/or expression profile. Vitamin D 121-124 vitamin D receptor Homo sapiens 182-185 31940280-1 2020 The biologically active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (VD3) exerts its tissue-specific actions through binding to its intracellular vitamin D receptor (VDR) which functions as a heterodimer with retinoid X receptor (RXR) to recognize vitamin D response elements (VDRE) and activate target genes. Vitamin D 38-47 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 152-170 31940280-1 2020 The biologically active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (VD3) exerts its tissue-specific actions through binding to its intracellular vitamin D receptor (VDR) which functions as a heterodimer with retinoid X receptor (RXR) to recognize vitamin D response elements (VDRE) and activate target genes. Vitamin D 38-47 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 172-175 31940280-1 2020 The biologically active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (VD3) exerts its tissue-specific actions through binding to its intracellular vitamin D receptor (VDR) which functions as a heterodimer with retinoid X receptor (RXR) to recognize vitamin D response elements (VDRE) and activate target genes. Vitamin D 63-72 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 152-170 31940280-1 2020 The biologically active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (VD3) exerts its tissue-specific actions through binding to its intracellular vitamin D receptor (VDR) which functions as a heterodimer with retinoid X receptor (RXR) to recognize vitamin D response elements (VDRE) and activate target genes. Vitamin D 63-72 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 172-175 31770575-0 2020 Association between CUBN gene variants, type 2 diabetes and vitamin D concentrations in an elderly Greek population. Vitamin D 60-69 cubilin Homo sapiens 20-24 31770575-2 2020 The megalin-cubilin endocytotic system constitutes a key transport structure, with a modulating role in vitamin D metabolism. Vitamin D 104-113 cubilin Homo sapiens 12-19 31783153-0 2020 A mouse model for vitamin D-induced human cathelicidin antimicrobial peptide gene expression. Vitamin D 18-27 cathelicidin antimicrobial peptide Mus musculus 42-76 31783153-2 2020 Mice and other mammals lack the vitamin D response element (VDRE) in their CAMP promoters. Vitamin D 32-41 cathelicidin antimicrobial peptide Mus musculus 75-79 31809868-13 2020 In addition, leptin downregulated CYP24A1 and upregulated CYP27B1, CYP27A1 and VDR, which play vital roles in vitamin D metabolism. Vitamin D 110-119 vitamin D receptor Homo sapiens 79-82 31881310-2 2020 Transepithelial intestinal Ca absorption is mediated by 1,25-dihydroxyvitamin D (1,25(OH)2D, calcitriol) through the vitamin D receptor (VDR). Vitamin D 70-79 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 137-140 32029884-8 2020 We then discuss the epidermis and hair follicle, to provide a non-skeletal example of a tissue that expresses VDR that not only makes vitamin D but also can metabolize it to its hormonally active form. Vitamin D 134-143 vitamin D receptor Homo sapiens 110-113 32489362-4 2020 Meanwhile, the vitamin D levels in patients with chronic spontaneous urticaria were also detected and the effects of VDR gene polymorphism on vitamin D levels were detected. Vitamin D 142-151 vitamin D receptor Homo sapiens 117-120 32489362-8 2020 However, the effect of VDR gene polymorphism on vitamin D levels was not found in patients of CSU. Vitamin D 48-57 vitamin D receptor Homo sapiens 23-26 31982424-0 2020 Active Form of Vitamin D Analogue Mitigates Neurodegenerative Changes in Alzheimer"s Disease in Rats by Targeting Keap1/Nrf2 and MAPK-38p/ERK signaling pathways. Vitamin D 15-24 Kelch-like ECH-associated protein 1 Rattus norvegicus 114-119 31982424-3 2020 The present study was conducted to evaluate the effects of active vitamin D analogue, Maxacalcitol, on Keap1-Nrf2 signaling pathway in experimental Alzheimer"s disease in rats. Vitamin D 66-75 Kelch-like ECH-associated protein 1 Rattus norvegicus 103-108 31982424-11 2020 Also, Vitamin D analogue significantly increased expression of Nrf2 and its downstream effectors (HO-1 and GSH), improved serum levels of total 25-hydroxyvitamin D and calcium, decreased neuro-inflammation and Amyloid beta load as well as hyperphosphorylation of MAPK-38, ERK1/2 and tau proteins were also observed. Vitamin D 6-15 heme oxygenase 1 Rattus norvegicus 98-110 32213983-3 2020 We developed an adenoviral vector for human VDR and performed transcriptomic and metabolomic analyses of cultured human hepatocytes upon VDR activation by vitamin D (VitD). Vitamin D 155-164 vitamin D receptor Homo sapiens 137-140 32213983-5 2020 They were rapidly induced (4-6 h) upon VDR activation by 10 nM VitD or 100 microM lithocholic acid (LCA). Vitamin D 63-67 vitamin D receptor Homo sapiens 39-42 32208427-12 2020 Stress fracture risk in RM recruits is impacted by the interaction of VDR genotype with vitamin D status. Vitamin D 88-97 vitamin D receptor Homo sapiens 70-73 32051143-0 2020 Vitamin D receptor targets hepatocyte nuclear factor 4alpha and mediates protective effects of vitamin D in nonalcoholic fatty liver disease. Vitamin D 95-104 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 0-18 32051143-6 2020 Liver-specific VDR deletion significantly exacerbated HFD- or MCD-induced hepatic steatosis and insulin resistance and also diminished the protective effect of vitamin D supplementation on NAFLD. Vitamin D 160-169 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 15-18 32051143-8 2020 These results suggest that vitamin D ameliorates NAFLD and metabolic abnormalities by activating hepatic VDR, leading to its interaction with HNF4alpha. Vitamin D 27-36 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 105-108 32051143-8 2020 These results suggest that vitamin D ameliorates NAFLD and metabolic abnormalities by activating hepatic VDR, leading to its interaction with HNF4alpha. Vitamin D 27-36 hepatic nuclear factor 4, alpha Mus musculus 142-151 32051143-9 2020 Our findings highlight a potential value of using vitamin D for preventing and managing NAFLD by targeting VDR. Vitamin D 50-59 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 107-110 32204545-7 2020 Megalin-Cubilin-Amnionless and the FGF23-Klotho axis represent two Vitamin D-linked mechanisms that could modulate and ameliorate the damage response at the renal tubular level, balancing Vitamin D therapy with an effect potent enough to contrast the inflammatory cascades, but which avoids potential severe side effects. Vitamin D 67-76 cubilin Homo sapiens 8-15 32204545-7 2020 Megalin-Cubilin-Amnionless and the FGF23-Klotho axis represent two Vitamin D-linked mechanisms that could modulate and ameliorate the damage response at the renal tubular level, balancing Vitamin D therapy with an effect potent enough to contrast the inflammatory cascades, but which avoids potential severe side effects. Vitamin D 67-76 fibroblast growth factor 23 Homo sapiens 35-40 32204545-7 2020 Megalin-Cubilin-Amnionless and the FGF23-Klotho axis represent two Vitamin D-linked mechanisms that could modulate and ameliorate the damage response at the renal tubular level, balancing Vitamin D therapy with an effect potent enough to contrast the inflammatory cascades, but which avoids potential severe side effects. Vitamin D 67-76 klotho Homo sapiens 41-47 32204545-7 2020 Megalin-Cubilin-Amnionless and the FGF23-Klotho axis represent two Vitamin D-linked mechanisms that could modulate and ameliorate the damage response at the renal tubular level, balancing Vitamin D therapy with an effect potent enough to contrast the inflammatory cascades, but which avoids potential severe side effects. Vitamin D 188-197 cubilin Homo sapiens 8-15 32204545-7 2020 Megalin-Cubilin-Amnionless and the FGF23-Klotho axis represent two Vitamin D-linked mechanisms that could modulate and ameliorate the damage response at the renal tubular level, balancing Vitamin D therapy with an effect potent enough to contrast the inflammatory cascades, but which avoids potential severe side effects. Vitamin D 188-197 klotho Homo sapiens 41-47 32206326-0 2020 Vitamin D status among postmenopausal osteoporotic women: a hospital based cross-sectional study from Northern Sri Lanka. Vitamin D 0-9 sorcin Homo sapiens 111-114 32206326-2 2020 Few studies examined the prevalence of vitamin D deficiency in general population of Sri Lanka but no studies to date done among post-menopausal women with osteoporosis in Sri Lanka. Vitamin D 39-48 sorcin Homo sapiens 85-88 32206326-3 2020 This is the first study in Sri Lanka of such kind conducted to evaluate the serum vitamin D levels among postmenopausal women. Vitamin D 82-91 sorcin Homo sapiens 27-30 32184381-0 2020 Correction: Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NF-kappaB pathway activation through RPS3. Vitamin D 12-21 lipocalin 2 Homo sapiens 103-107 32184381-0 2020 Correction: Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NF-kappaB pathway activation through RPS3. Vitamin D 12-21 ribosomal protein S3 Homo sapiens 155-159 32183826-2 2020 This study was designed to assess how expression of the endometrial vitamin D receptor (VDR) and CYP27B1, a vitamin D metabolizing enzyme, change during the menstrual cycle in women of reproductive age. Vitamin D 68-77 vitamin D receptor Homo sapiens 88-91 32183826-9 2020 In addition, serum vitamin D levels were positively correlated with VDR and HOXA10 protein levels in the endometrium. Vitamin D 19-28 vitamin D receptor Homo sapiens 68-71 31255367-3 2020 The aim of this study was to examine the association between vitamin D status and circulating Lp-PLA2 levels in subjects with type 2 diabetes mellitus. Vitamin D 61-70 phospholipase A2 group VII Homo sapiens 94-101 31255367-7 2020 The vitamin D insufficiency group had higher serum LP-PLA2 levels than the vitamin D sufficiency group (t=-2.765, p=.005). Vitamin D 4-13 phospholipase A2 group VII Homo sapiens 51-58 31255367-8 2020 A significant negative correlation was noted between Lp-PLA2 and 25(OH)D in the vitamin D insufficiency group (r=-0.364, p=0.009). Vitamin D 80-89 phospholipase A2 group VII Homo sapiens 53-60 32056782-1 2020 INTRODUCTION: Vitamin D catabolizing enzymes, along with vitamin D receptor (VDR) and vitamin D binding protein (DBP) are expressed in the decidua and placenta during pregnancy and capable of synthesizing active vitamin D. Vitamin D 14-23 vitamin D receptor Homo sapiens 77-80 32056782-1 2020 INTRODUCTION: Vitamin D catabolizing enzymes, along with vitamin D receptor (VDR) and vitamin D binding protein (DBP) are expressed in the decidua and placenta during pregnancy and capable of synthesizing active vitamin D. Vitamin D 57-66 vitamin D receptor Homo sapiens 77-80 31924508-1 2020 The aim of this study was to demonstrate the effects of vitamin D treatment on ultrastructural changes and AMHR2 expression in the ovary in PCOS rat model. Vitamin D 56-65 anti-Mullerian hormone receptor type 2 Rattus norvegicus 107-112 32102427-7 2020 There was a significant negative association between serum TNFR-2 and vitamin D levels in the whole sample. Vitamin D 70-79 TNF receptor superfamily member 1B Homo sapiens 59-65 31942011-8 2020 In sum, our results show that vitamin D/VDR signaling induces miR-27a/b in oral lichen planus. Vitamin D 30-39 vitamin D receptor Homo sapiens 40-43 31998239-1 2019 Vitamin D and all its metabolites are bound to a specific vitamin D binding protein, DBP. Vitamin D 0-9 GC vitamin D binding protein Homo sapiens 58-83 32918214-6 2020 It seems probable that other factors such as ethnicity, phenotype, 25(OH)D plasma levels, and UV radiation exposure play a role as confounding factors and introduce heterogeneity.To conclude, there is some indication that VDR polymorphisms may modulate the risk of some cancer sites and in future studies VDR genetic variation should be integrated also with assessment of vitamin D status and stratified by ethnicity. Vitamin D 372-381 vitamin D receptor Homo sapiens 222-225 32918222-4 2020 The hormone derived from vitamin D, calcitriol (1,25-dihydroxyvitamin D3) and other related compounds, working via the vitamin D receptor and at least in part through endoplasmic reticulum protein 57 (ERp57), reduce cyclobutane pyrimidine dimers and oxidative DNA damage in keratinocytes and other skin cell types after UV. Vitamin D 25-34 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 119-137 32918224-5 2020 These cells not only produce vitamin D but contain the enzymatic machinery to metabolize vitamin D to its active metabolite, 1,25(OH)2D, and express the receptor for this metabolite, the vitamin D receptor (VDR). Vitamin D 29-38 vitamin D receptor Homo sapiens 187-205 32918224-5 2020 These cells not only produce vitamin D but contain the enzymatic machinery to metabolize vitamin D to its active metabolite, 1,25(OH)2D, and express the receptor for this metabolite, the vitamin D receptor (VDR). Vitamin D 29-38 vitamin D receptor Homo sapiens 207-210 32918224-5 2020 These cells not only produce vitamin D but contain the enzymatic machinery to metabolize vitamin D to its active metabolite, 1,25(OH)2D, and express the receptor for this metabolite, the vitamin D receptor (VDR). Vitamin D 89-98 vitamin D receptor Homo sapiens 187-205 32918224-5 2020 These cells not only produce vitamin D but contain the enzymatic machinery to metabolize vitamin D to its active metabolite, 1,25(OH)2D, and express the receptor for this metabolite, the vitamin D receptor (VDR). Vitamin D 89-98 vitamin D receptor Homo sapiens 207-210 32918224-9 2020 They are inhibition of proliferation/stimulation of differentiation with discussion of the roles of hedgehog, Wnt/beta-catenin, and hyaluronan/CD44 pathways in mediating vitamin D regulation of proliferation/differentiation, regulation of the balance between oncogenic and tumor suppressor long noncoding RNAs, immune regulation, and promotion of DNA damage repair (DDR). Vitamin D 170-179 CD44 molecule (Indian blood group) Homo sapiens 143-147 32918226-2 2020 The active form of vitamin D, vitamin D3 or calcitriol, binds to the ligand-activated transcription factor vitamin D receptor (VDR) for genomic and non-genomic effects. Vitamin D 19-28 vitamin D receptor Homo sapiens 107-125 32918226-2 2020 The active form of vitamin D, vitamin D3 or calcitriol, binds to the ligand-activated transcription factor vitamin D receptor (VDR) for genomic and non-genomic effects. Vitamin D 19-28 vitamin D receptor Homo sapiens 127-130 31614180-12 2020 At E14, the osteoblasts started to express the receptor for activated vitamin D (VDR). Vitamin D 70-79 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 81-84 32990627-1 2020 BACKGROUND AND OBJECTIVES: Vitamin D deficiency has been reported in patients with ulcerative colitis, and polymorphism in the gene encoding the vitamin D binding protein can affect the characteristics of vitamin D binding protein, thus affecting the level and function of vitamin D in vivo. Vitamin D 27-36 GC vitamin D binding protein Homo sapiens 145-170 32990627-1 2020 BACKGROUND AND OBJECTIVES: Vitamin D deficiency has been reported in patients with ulcerative colitis, and polymorphism in the gene encoding the vitamin D binding protein can affect the characteristics of vitamin D binding protein, thus affecting the level and function of vitamin D in vivo. Vitamin D 145-154 GC vitamin D binding protein Homo sapiens 205-230 31837111-6 2020 RESULTS: Administration of VitD promotes the proliferation and differentiation of neural stem cells in the subventricular zone and the migration of these cells to the lesion site in the corpus callosum; these cells subsequently differentiate into oligodendrocyte lineage cells and produce myelin basic protein. Vitamin D 27-31 myelin basic protein Rattus norvegicus 289-309 31837111-8 2020 Megalin expression did not increase at the lesion site, which suggests that VitD is internalized by other mechanisms. Vitamin D 76-80 LDL receptor related protein 2 Rattus norvegicus 0-7 31696340-2 2020 CYP24A1 is the key enzyme for metabolic inactivation of active VD (1,25(OH)2D3). Vitamin D 63-65 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 0-7 32497792-1 2020 BACKGROUND: Vitamin D exerts regulatory roles via vitamin D receptor (VDR) in mucosal immunity, host defense, and inflammation involving host factors and microbiome. Vitamin D 12-21 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 50-68 32497792-1 2020 BACKGROUND: Vitamin D exerts regulatory roles via vitamin D receptor (VDR) in mucosal immunity, host defense, and inflammation involving host factors and microbiome. Vitamin D 12-21 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 70-73 31006279-2 2020 The actions of the active form of vitamin D are mediated via the vitamin D receptor (VDR), which is expressed in numerous organs including placenta. Vitamin D 34-43 vitamin D receptor Homo sapiens 65-83 31006279-2 2020 The actions of the active form of vitamin D are mediated via the vitamin D receptor (VDR), which is expressed in numerous organs including placenta. Vitamin D 34-43 vitamin D receptor Homo sapiens 85-88 32013346-0 2020 Vitamin D - Deglycosylated Vitamin D Binding Protein Dimer: Positive Synergistic Effects on Recognition, Activation, Phagocytosis and Oxidative Stress on Macrophages. Vitamin D 0-9 GC vitamin D binding protein Homo sapiens 27-52 32013346-7 2020 25(OH) vitamin D levels of VDBP (20.7 nmol/mg; p < 0.001) and dgVDBP (28.8 +/- 3.9 nmol/mL; p < 0.001) was significantly lower than of VitD~dgVDBP (324.0 +/- 12.8 nmol/mL). Vitamin D 7-16 GC vitamin D binding protein Homo sapiens 27-31 32013346-11 2020 CONCLUSIONS: VitD~dgVDBP (Il-42) showed higher macrophage activation and lower oxidative burst than VitD free dgVDBP (GcMaf) and VDBP (Gc) which may result from a synergistic effect by presenting protein bound Vitamin D better to macrophages. Vitamin D 210-219 GC vitamin D binding protein Homo sapiens 20-24 31704050-1 2020 OBJECTIVES: To investigate the effect of oral vitamin D-calcium supplementation on serum intact parathyroid hormone (PTH), calcium, phosphorous, and alkaline phosphatase (ALK-P) concentrations in children with habitually low calcium intakes. Vitamin D 46-55 ALK receptor tyrosine kinase Homo sapiens 171-174 31918428-2 2020 CYP24A1 regulates vitamin D activity and is closely linked to hypertension. Vitamin D 18-27 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 0-7 31892349-0 2019 Association between vitamin D plasma concentrations and VDR gene variants and the risk of premature birth. Vitamin D 20-29 vitamin D receptor Homo sapiens 56-59 31892349-2 2019 The effects of vitamin D are mediated by its receptor, which is encoded by the VDR gene. Vitamin D 15-24 vitamin D receptor Homo sapiens 79-82 31892349-13 2019 CONCLUSIONS: VDR variants contribute to variations in vitamin D concentrations and the increased risk of prematurity. Vitamin D 54-63 vitamin D receptor Homo sapiens 13-16 31877961-7 2019 On molecular level, the WD reduced proliferation (p < 0.05) and increased expression of the vitamin D catabolizing enzyme Cyp24a1 (p < 0.001). Vitamin D 92-101 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 122-129 31618573-2 2019 In the present study, we dissect the complex biological activity of vitamin D by designing synthetic vitamin D3 analogs specific for VDR or SREBP pathway, i.e., a VDR activator that lacks SREBP inhibitory activity, or an SREBP inhibitor devoid of VDR activity. Vitamin D 68-77 vitamin D receptor Homo sapiens 133-136 31823791-0 2019 OPG/RANK/RANKL signaling axis in patients with type I diabetes: Associations with parathormone and vitamin D. Vitamin D 99-108 TNF superfamily member 11 Homo sapiens 9-14 31819048-0 2019 Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NF-kappaB pathway activation through RPS3. Vitamin D 0-9 lipocalin 2 Homo sapiens 91-95 31819048-0 2019 Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NF-kappaB pathway activation through RPS3. Vitamin D 0-9 ribosomal protein S3 Homo sapiens 143-147 31819048-7 2019 Cisplatin enhanced the expression of LCN2 by decreasing methylation at the promoter, whereas vitamin D enhanced methylation and thereby inhibited the expression of LCN2. Vitamin D 93-102 lipocalin 2 Homo sapiens 164-168 31748273-0 2019 Vitamin D binding protein is required to utilize skin-generated vitamin D. Vitamin D 64-73 vitamin D binding protein Mus musculus 0-25 31748273-5 2019 It has been assumed that cutaneous vitamin D is transported into the circulation by vitamin D binding protein (DBP), but experimental evidence is lacking. Vitamin D 35-44 vitamin D binding protein Mus musculus 84-109 31292859-3 2019 Recent evidence suggests vitamin D has a critical role in maintaining heart health through activation of the vitamin D receptor expressed in cardiomyocytes, and vitamin D deficiency may be implicated in the pathophysiology of HFrEF through activation of the renin-angiotensin system, impaired calcium handling, exaggerated inflammation, secondary hyperparathyroidism, pro-fibrotic properties, and proatherogenic potential. Vitamin D 25-34 vitamin D receptor Homo sapiens 109-127 31599948-1 2019 Fibroblast growth factor 23 (FGF23) is a bone-derived hormone involved in the control of phosphate (P) homeostasis and vitamin D metabolism. Vitamin D 119-128 fibroblast growth factor 23 Mus musculus 0-27 31599948-1 2019 Fibroblast growth factor 23 (FGF23) is a bone-derived hormone involved in the control of phosphate (P) homeostasis and vitamin D metabolism. Vitamin D 119-128 fibroblast growth factor 23 Mus musculus 29-34 31465293-0 2019 The role of vitamin D replacement therapy in serum FGF23 concentration in children with myelomeningocele compared with healthy children - a preliminary study. Vitamin D 12-21 fibroblast growth factor 23 Homo sapiens 51-56 31465293-1 2019 Background Fibroblast growth factor 23 (FGF23) is a recently discovered bone-derived regulator of vitamin D metabolism and phosphate homeostasis. Vitamin D 98-107 fibroblast growth factor 23 Homo sapiens 11-38 31465293-1 2019 Background Fibroblast growth factor 23 (FGF23) is a recently discovered bone-derived regulator of vitamin D metabolism and phosphate homeostasis. Vitamin D 98-107 fibroblast growth factor 23 Homo sapiens 40-45 31465293-4 2019 We aimed to investigate the influence of vitamin D replacement therapy on serum FGF23 concentration in children with MMC and compare the results with healthy participants. Vitamin D 41-50 fibroblast growth factor 23 Homo sapiens 80-85 31465293-10 2019 In MMC children we found a significant decrease in median serum FGF23 after vitamin D replacement therapy (from 42.1 to 0 RU/mL, p < 0.001). Vitamin D 76-85 fibroblast growth factor 23 Homo sapiens 64-69 31465293-15 2019 Vitamin D replacement therapy decreases FGF23 concentrations in MMC children, although further studies are still warranted to gain detailed insight on the FGF23 in the MMC population. Vitamin D 0-9 fibroblast growth factor 23 Homo sapiens 40-45 31731733-9 2019 Moreover, the studies for an adopted vitamin D supplementation due to breast cancer focality type must be enlarged to fully comprehend the remarkable and interesting role played by the vitamin D receptor. Vitamin D 37-46 vitamin D receptor Homo sapiens 185-203 31867158-6 2019 Activated VDR forms a heterodimer with retinoid X receptor alpha (RXRalpha), recruits co-activators, translocates to the cell nucleus, binds to the specific vitamin D responsive elements (VDRE), and activates the gene transcription. Vitamin D 157-166 vitamin D receptor Homo sapiens 10-13 31867158-6 2019 Activated VDR forms a heterodimer with retinoid X receptor alpha (RXRalpha), recruits co-activators, translocates to the cell nucleus, binds to the specific vitamin D responsive elements (VDRE), and activates the gene transcription. Vitamin D 157-166 retinoid X receptor alpha Homo sapiens 39-64 31867158-6 2019 Activated VDR forms a heterodimer with retinoid X receptor alpha (RXRalpha), recruits co-activators, translocates to the cell nucleus, binds to the specific vitamin D responsive elements (VDRE), and activates the gene transcription. Vitamin D 157-166 retinoid X receptor alpha Homo sapiens 66-74 31589177-6 2019 Genetic and experimental evidence suggests that vitamin D and the vitamin D receptor (VDR) may influence the gut microbiome in health and disease. Vitamin D 66-75 vitamin D receptor Homo sapiens 86-89 31570180-0 2019 Predictive role of IL-17A/IL-10 ratio in persistent asthmatic patients on vitamin D supplement. Vitamin D 74-83 interleukin 17A Homo sapiens 19-25 31570180-0 2019 Predictive role of IL-17A/IL-10 ratio in persistent asthmatic patients on vitamin D supplement. Vitamin D 74-83 interleukin 10 Homo sapiens 26-31 31570180-4 2019 This study aims to investigate the role of IL-17A and IL-10 in predicting asthma control in case of Vit D supplementation. Vitamin D 100-105 interleukin 17A Homo sapiens 43-49 31570180-4 2019 This study aims to investigate the role of IL-17A and IL-10 in predicting asthma control in case of Vit D supplementation. Vitamin D 100-105 interleukin 10 Homo sapiens 54-59 31570180-12 2019 Vit D supplementation reduces the serum IL-17A levels and elevates the serum IL-10 levels in persistent asthmatic patients. Vitamin D 0-5 interleukin 17A Homo sapiens 40-46 31570180-12 2019 Vit D supplementation reduces the serum IL-17A levels and elevates the serum IL-10 levels in persistent asthmatic patients. Vitamin D 0-5 interleukin 10 Homo sapiens 77-82 31570180-14 2019 The IL-17A/IL-10 ratio seems to be a possible predictive biomarker for asthma improvement in patients depending on Vit D supplementation. Vitamin D 115-120 interleukin 17A Homo sapiens 4-10 31570180-14 2019 The IL-17A/IL-10 ratio seems to be a possible predictive biomarker for asthma improvement in patients depending on Vit D supplementation. Vitamin D 115-120 interleukin 10 Homo sapiens 11-16 30829137-1 2019 The present randomized, double-blind, placebo controlled study aimed to evaluate the effect of vitamin D supplementation on matrix metalloproteinases-2, -9 (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in subjects with metabolic syndrome. Vitamin D 95-104 matrix metallopeptidase 9 Homo sapiens 167-172 31173353-9 2019 CONCLUSIONS: Vitamin D might contribute in reducing diabetic cardiomyopathy not only by improving blood glucose and insulin levels but also via downregulating AGE and hexosamine pathways and decreasing NF-kB activity in heart tissue. Vitamin D 13-22 renin binding protein Rattus norvegicus 159-162 31372708-0 2019 Oral vitamin D3 supplementation increases serum fibroblast growth factor 23 concentration in vitamin D-deficient patients: a systematic review and meta-analysis. Vitamin D 5-14 fibroblast growth factor 23 Homo sapiens 48-75 31372708-1 2019 Studies have suggested that vitamin D supplementation may increase serum fibroblast growth factor 23 (FGF23) among vitamin D-deficient patients although the results were inconsistent across the studies. Vitamin D 28-37 fibroblast growth factor 23 Homo sapiens 73-100 31372708-1 2019 Studies have suggested that vitamin D supplementation may increase serum fibroblast growth factor 23 (FGF23) among vitamin D-deficient patients although the results were inconsistent across the studies. Vitamin D 28-37 fibroblast growth factor 23 Homo sapiens 102-107 31372708-1 2019 Studies have suggested that vitamin D supplementation may increase serum fibroblast growth factor 23 (FGF23) among vitamin D-deficient patients although the results were inconsistent across the studies. Vitamin D 115-124 fibroblast growth factor 23 Homo sapiens 73-100 31372708-1 2019 Studies have suggested that vitamin D supplementation may increase serum fibroblast growth factor 23 (FGF23) among vitamin D-deficient patients although the results were inconsistent across the studies. Vitamin D 115-124 fibroblast growth factor 23 Homo sapiens 102-107 31372708-8 2019 The meta-analyses found that serum intact FGF23 increased significantly after oral vitamin D3 supplementation in vitamin D-deficient participants with the pooled SMD of 0.36 (95%CI, 0.14, 0.57; p = 0.001; I2 of 36%). Vitamin D 83-92 fibroblast growth factor 23 Homo sapiens 42-47 31372708-9 2019 Serum C-terminal FGF23 also increased after vitamin D3 supplementation in vitamin D-deficient participants with the pooled SMD of 0.28 although without reaching statistical significance (95%CI, - 0.08, 0.65; p = 0.13; I2 of 0%). Vitamin D 44-53 fibroblast growth factor 23 Homo sapiens 17-22 31372708-11 2019 Vitamin D supplementation leads to a significant increase in serum intact FGF23 among vitamin D-deficient patients. Vitamin D 0-9 fibroblast growth factor 23 Homo sapiens 74-79 31372708-11 2019 Vitamin D supplementation leads to a significant increase in serum intact FGF23 among vitamin D-deficient patients. Vitamin D 86-95 fibroblast growth factor 23 Homo sapiens 74-79 31372708-13 2019 The present systematic review and meta-analysis revealed that serum intact FGF23 concentration increased significantly after oral vitamin D3 supplementation in vitamin D-deficient participants. Vitamin D 130-139 fibroblast growth factor 23 Homo sapiens 75-80 31719947-6 2019 Logistic regression analyses were performed to detect an association between allergic asthma status and the interaction of the VDR SNP and serum vitamin D concentration in the case-control samples. Vitamin D 145-154 vitamin D receptor Homo sapiens 127-130 31635074-4 2019 The results demonstrated an improvement of the insulin signalling pathway upon treatment with vitamin D alone, with significant increases in IR, PI3K, GLUT3, GLUT4 expression levels, as well as AKT phosphorylation and glucose uptake, while GSK3beta and TAU expression levels was decreased significantly. Vitamin D 94-103 solute carrier family 2 member 3 Homo sapiens 151-156 32117550-4 2019 Prescribing supplementary vitamin D as a part of the MS treatment plan can increase G6PD gene expression. Vitamin D 26-35 glucose-6-phosphate dehydrogenase Homo sapiens 84-88 32117550-5 2019 The aim of this study was to determine the serum level of G6PD in patients with MS and NMO and its relationship with vitamin D, since it is yet to be explored thoroughly. Vitamin D 117-126 glucose-6-phosphate dehydrogenase Homo sapiens 58-62 32117550-11 2019 G6PD serum level was significantly higher in patients with MS who had previously consumed supplementary vitamin D compared to those who had not. Vitamin D 104-113 glucose-6-phosphate dehydrogenase Homo sapiens 0-4 32117550-13 2019 Also, supplementary vitamin D may induce favorable results on the G6PD level. Vitamin D 20-29 glucose-6-phosphate dehydrogenase Homo sapiens 66-70 31582399-4 2019 RESULTS: Vitamin D enhanced in vitro IFN responses, as measured by induction of p-Y-STAT1 and MxA in MNCs, T cells, and monocytes. Vitamin D 9-18 signal transducer and activator of transcription 1 Homo sapiens 84-89 31582399-6 2019 The combination of vitamin D plus IFN-beta reduced Th1 and Th17 cytokines, and increased Th2 responses, reversing the effect of IFN-beta alone. Vitamin D 19-28 negative elongation factor complex member C/D Homo sapiens 51-54 31377240-0 2019 Vitamin D sterols increase FGF23 expression by stimulating osteoblast and osteocyte maturation in CKD bone. Vitamin D 0-9 fibroblast growth factor 23 Homo sapiens 27-32 31415247-2 2019 In patients with thrombotic state and vitamin D deficiency, vitamin D analogs and vitamin D receptor activators have been determined as adjunctive anticoagulant treatment in previous studies. Vitamin D 38-47 vitamin D receptor Homo sapiens 82-100 31250032-5 2019 Experimental findings have shown that vitamin D regulates AGE/RAGE signaling and its downstream effects. Vitamin D 38-47 advanced glycosylation end-product specific receptor Homo sapiens 62-66 31250032-6 2019 This article provides a comprehensive review of the mechanistic insights into AGE/RAGE involvement in CVDs and the modulation of the AGE/RAGE signaling pathways by vitamin D. Vitamin D 164-173 advanced glycosylation end-product specific receptor Homo sapiens 137-141 31465769-3 2019 These vitamin D-derived metabolites signal through the vitamin D receptor (VDR). Vitamin D 6-15 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 55-73 31465769-3 2019 These vitamin D-derived metabolites signal through the vitamin D receptor (VDR). Vitamin D 6-15 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 75-78 31465769-15 2019 These vitamin D metabolites appear to signal through both VDR-dependent and -independent pathways. Vitamin D 6-15 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 58-61 31115927-1 2019 Vitamin D (Vit D) increases calcium absorption in the intestine after binding to the Vit D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 85-99 31115927-1 2019 Vitamin D (Vit D) increases calcium absorption in the intestine after binding to the Vit D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 101-104 31326626-0 2019 Differential response of lung cancer cell lines to vitamin D derivatives depending on EGFR, KRAS, p53 mutation status and VDR polymorphism. Vitamin D 51-60 KRAS proto-oncogene, GTPase Homo sapiens 92-96 31326626-0 2019 Differential response of lung cancer cell lines to vitamin D derivatives depending on EGFR, KRAS, p53 mutation status and VDR polymorphism. Vitamin D 51-60 vitamin D receptor Homo sapiens 122-125 31326626-5 2019 The goal of our study was to establish if cells differing in EGFR, KRAS, p53 mutation status and VDR polymorphism were sensitive to antiproliferative activity of selected vitamin D derivatives (VDDs). Vitamin D 171-180 KRAS proto-oncogene, GTPase Homo sapiens 67-71 31326626-5 2019 The goal of our study was to establish if cells differing in EGFR, KRAS, p53 mutation status and VDR polymorphism were sensitive to antiproliferative activity of selected vitamin D derivatives (VDDs). Vitamin D 171-180 vitamin D receptor Homo sapiens 97-100 31415769-1 2019 AIMS: Vitamin D and its receptor, vitamin D receptor (VDR), have renoprotection effect against diabetic nephropathy (DN). Vitamin D 6-15 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 34-52 31415769-1 2019 AIMS: Vitamin D and its receptor, vitamin D receptor (VDR), have renoprotection effect against diabetic nephropathy (DN). Vitamin D 6-15 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 54-57 31463983-9 2019 In addition, vitamin D deficiency alleviated alcohol-induced downregulation of hepatic nuclear peroxisome proliferator-activated receptor (PPAR)alpha, which governs FA transport and beta-oxidation, and the expression of Carnitine palmitoyltransferase (Cpt)-1alpha, cytochrome P450, family 4, subfamily a, polypeptide (Cyp4a)10, and Cyp4a14, which are key enzymes for hepatic fatty acids beta-oxidation and omega-oxidation. Vitamin D 13-22 cytochrome P450, family 4, subfamily a, polypeptide 10 Mus musculus 318-323 31187385-9 2019 Expression of LINC00346 was inversely correlated with vitamin D levels only in male epileptic patients (r = -0.58, P = 0.011). Vitamin D 54-63 p53 regulated carcinoma associated Stat3 activating long intergenic non-protein coding transcript Homo sapiens 14-23 31187385-10 2019 Expression of SNHG6 was correlated with vitamin D levels in male controls but no other subgroups (r = 0.51, P = 0.044). Vitamin D 40-49 small nucleolar RNA host gene 6 Homo sapiens 14-19 31359379-5 2019 In addition, lower level of vitamin D strongly increased the risk of CAD (15 +- 11.02 vs. 21.3 +- 18 mug/L, p = 0.043) and AMVC (12.1 +- 13.1 vs.21.3 +- 18 mug/L, p = 0.014) development in individuals carrying T/T genotype of VDBP 7041 T>G gene polymorphism. Vitamin D 28-37 GC vitamin D binding protein Homo sapiens 226-230 31359379-8 2019 Our findings for the first time indicated that there is a strong association between vitamin D deficiency, lipid profile and the VDR rs1544410G>A and rs7T41>G VDBP genes polymorphisms. Vitamin D 85-94 vitamin D receptor Homo sapiens 129-132 31359379-8 2019 Our findings for the first time indicated that there is a strong association between vitamin D deficiency, lipid profile and the VDR rs1544410G>A and rs7T41>G VDBP genes polymorphisms. Vitamin D 85-94 GC vitamin D binding protein Homo sapiens 165-169 31455010-0 2019 Investigating the Role of VDR and Megalin in Semi-Selectivity of Side-Chain Modified 19-nor Analogs of Vitamin D. Vitamin D 103-112 vitamin D receptor Homo sapiens 26-29 31450606-3 2019 Epidemiological and genetic association studies demonstrate that VITD may have a protective role in AMD, while single nucleotide polymorphisms in the vitamin D metabolism gene (CYP24A1) increase the risk of AMD. Vitamin D 150-159 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 177-184 31300316-1 2019 Lithocholic acid (2) was identified as the second endogenous ligand of vitamin D receptor (VDR), though its binding affinity to VDR and its vitamin D activity are very weak compared to those of the active metabolite of vitamin D3, 1alpha,25-dihydroxyvitamin D3 (1). Vitamin D 71-80 vitamin D receptor Homo sapiens 91-94 30916559-5 2019 The nearly 150 crystal structures of VDR"s ligand-binding domain with various vitamin D compounds allow a detailed molecular understanding of their action. Vitamin D 78-87 vitamin D receptor Homo sapiens 37-40 32542086-3 2020 Polymorphisms in genes codifying molecules involved in vitamin D homeostasis have been associated with hypovitaminosis D. However, the influence of polymorphisms of Klotho, which codify a protein with a pivotal role in vitamin D metabolism, have never been investigated. Vitamin D 55-64 klotho Homo sapiens 165-171 32542086-3 2020 Polymorphisms in genes codifying molecules involved in vitamin D homeostasis have been associated with hypovitaminosis D. However, the influence of polymorphisms of Klotho, which codify a protein with a pivotal role in vitamin D metabolism, have never been investigated. Vitamin D 219-228 klotho Homo sapiens 165-171 31555688-8 2019 Results: Association of the VDBP (rs4588) T/T genotype with CAD patients after acute MI and correlation of VDBP (rs4588) genotype G/G with higher levels of total vitamin D were found. Vitamin D 162-171 GC vitamin D binding protein Homo sapiens 107-111 31043390-0 2019 Vitamin D Modifies the Incidence of Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation Depending on the Vitamin D Receptor (VDR) Polymorphisms. Vitamin D 0-9 vitamin D receptor Homo sapiens 122-140 31043390-0 2019 Vitamin D Modifies the Incidence of Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation Depending on the Vitamin D Receptor (VDR) Polymorphisms. Vitamin D 0-9 vitamin D receptor Homo sapiens 142-145 30922121-0 2019 Protective effect of vitamin D supplementation in a rat modal of preeclampsia: a possible implication of chemerin. Vitamin D 21-30 retinoic acid receptor responder 2 Rattus norvegicus 105-113 31044263-3 2019 INTRODUCTION: Fibroblast growth factor 23 (FGF23) is an endocrine hormone-regulating phosphate and vitamin D metabolism. Vitamin D 99-108 fibroblast growth factor 23 Homo sapiens 14-41 31044263-3 2019 INTRODUCTION: Fibroblast growth factor 23 (FGF23) is an endocrine hormone-regulating phosphate and vitamin D metabolism. Vitamin D 99-108 fibroblast growth factor 23 Homo sapiens 43-48 31044263-10 2019 CONCLUSIONS: Taken together, high FGF23 levels are associated with impaired trabecular bone microarchitecture in osteoporosis patients, and this association seems to occur after adjustment of confounding variables including phosphate and vitamin D. Vitamin D 238-247 fibroblast growth factor 23 Homo sapiens 34-39 31252402-6 2019 RNA-sequencing revealed a Vitamin D dose-response gene signature enriched with a higher number of VDR-responsive elements (VDREs) per gene. Vitamin D 26-35 vitamin D receptor Homo sapiens 98-101 31330869-0 2019 Vitamin D Alleviates Rotavirus Infection through a Microrna-155-5p Mediated Regulation of the TBK1/IRF3 Signaling Pathway In Vivo and In Vitro. Vitamin D 0-9 TANK binding kinase 1 Sus scrofa 94-98 31292298-0 2019 Vitamin D-regulated osteocytic sclerostin and BMP2 modulate uremic extraskeletal calcification. Vitamin D 0-9 sclerostin Mus musculus 31-41 31360166-0 2019 Maternal Vitamin D Status and Its Effect on Vitamin D Levels in Early Infancy in a Tertiary Care Centre in Sri Lanka. Vitamin D 9-18 sorcin Homo sapiens 107-110 31360166-2 2019 However, there is very little information on vitamin D levels, especially in the vulnerable populations (pregnant/breast feeding mother and infants) in Sri Lanka. Vitamin D 45-54 sorcin Homo sapiens 152-155 31360166-5 2019 The purpose of this study was to investigate maternal vitamin D status and its effects on infants in a state sector tertiary care centre in Sri Lanka. Vitamin D 54-63 sorcin Homo sapiens 140-143 30929318-4 2019 OBJECTIVES: The aim of this study was to investigate the association of the TaqI polymorphism (rs731236, c.1056T >C) in the VDR gene with serum vitamin D concentration and bone mineral density (BMD) in patients with IBD. Vitamin D 147-156 vitamin D receptor Homo sapiens 127-130 31070844-1 2019 OBJECTIVES: This study evaluated the associations between single-nucleotide polymorphisms (SNPs) of the vitamin D receptor (VDR) gene, maternal vitamin D concentration, and gestational outcomes. Vitamin D 104-113 vitamin D receptor Homo sapiens 124-127 31070844-9 2019 CONCLUSIONS: The VDR gene is an important genetic predictor of a higher concentration of vitamin D during gestation, low birth weight, and decreasing duration of gestation. Vitamin D 89-98 vitamin D receptor Homo sapiens 17-20 31926498-0 2019 Serum Level of IL 10 is Significantly Increased in Allergic Rhinitis Patients on Subcutaneous Immunotherapy and Vitamin D Supplementation. Vitamin D 112-121 interleukin 10 Homo sapiens 15-20 31926498-4 2019 Objective of this study was to assess role of Vitamin D supplementation with SCIT in inducing tolerance to pollen, increasing IL10 and improving symptoms in AR patients. Vitamin D 46-55 interleukin 10 Homo sapiens 126-130 31926498-9 2019 In conclusion, serum level of IL 10 is significantly increased in AR patients on SCIT and Vitamin D supplementation. Vitamin D 90-99 interleukin 10 Homo sapiens 30-35 31029431-14 2019 CONCLUSION(S): The VDR is expressed throughout the organs of reproduction, suggesting a role for vitamin D in reproduction. Vitamin D 97-106 vitamin D receptor Homo sapiens 19-22 31037817-1 2019 FGF-23 is a 32 kDa protein that is a key regulator of phosphorus and vitamin D metabolism. Vitamin D 69-78 fibroblast growth factor 23 Homo sapiens 0-6 30308088-4 2019 In the process we explore the mechanisms postulated to explain the action of these vitamin D analogues including action through the vitamin D receptor, action through other receptors e.g. FAM57B2 and dual action on transcriptional processes. Vitamin D 83-92 vitamin D receptor Homo sapiens 132-150 31028080-6 2019 Analysis of the VDR cistrome in RWPE1 prostate epithelial cells revealed vitamin D-mediated regulation of multiple cancer-relevant pathways. Vitamin D 73-82 vitamin D receptor Homo sapiens 16-19 30613854-1 2019 INTRODUCTION: X-linked hypophosphatemic rickets (XLH) can occasionally cause premature fusion of cranial sutures through an increased level of fibroblast growth factor 23 (FGF-23), which leads to the dysregulation of phosphate and vitamin D metabolism. Vitamin D 231-240 fibroblast growth factor 23 Homo sapiens 143-170 30613854-1 2019 INTRODUCTION: X-linked hypophosphatemic rickets (XLH) can occasionally cause premature fusion of cranial sutures through an increased level of fibroblast growth factor 23 (FGF-23), which leads to the dysregulation of phosphate and vitamin D metabolism. Vitamin D 231-240 fibroblast growth factor 23 Homo sapiens 172-178 32022412-0 2019 Are soluble ST2 levels influenced by vitamin D and/or the seasons? Vitamin D 37-46 ST2 Homo sapiens 12-15 30731117-8 2019 It would be important to reconsider VDR as a pivotal molecule that mediates inter-organ communication to broaden the application of vitamin D signal modulators. Vitamin D 132-141 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 36-39 30923017-11 2019 In conclusion, we suggest that both VDR and CaSR might be useful as molecular markers for predicting treatment outcomes and identifying the CRC patient subgroups who might benefit from 5-FU-based chemotherapy combined with vitamin D analog. Vitamin D 223-232 vitamin D receptor Homo sapiens 36-39 30905091-1 2019 BACKGROUND: Vitamin D, a hormone that acts through the nuclear vitamin D receptor (VDR), upregulates antitumorigenic microRNA in prostate epithelium. Vitamin D 12-21 vitamin D receptor Homo sapiens 63-81 30905091-1 2019 BACKGROUND: Vitamin D, a hormone that acts through the nuclear vitamin D receptor (VDR), upregulates antitumorigenic microRNA in prostate epithelium. Vitamin D 12-21 vitamin D receptor Homo sapiens 83-86 30905091-5 2019 VDR chromatin immunoprecipitation-sequencing was performed to identify vitamin D genomic targets in primary prostate epithelial cells. Vitamin D 71-80 vitamin D receptor Homo sapiens 0-3 31179282-1 2019 Vitamin D possesses renoprotective effects beyond mineral metabolism, potentially reducing arterial blood pressure and inflammation and vitamin D enzymes (CYP24A1 and CYP27B1) as well as vitamin D receptor (VDR) contribute to its homeostasis. Vitamin D 0-9 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 155-162 31179282-1 2019 Vitamin D possesses renoprotective effects beyond mineral metabolism, potentially reducing arterial blood pressure and inflammation and vitamin D enzymes (CYP24A1 and CYP27B1) as well as vitamin D receptor (VDR) contribute to its homeostasis. Vitamin D 136-145 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 155-162 31191300-11 2019 Our data indicate that supplementation with vitamin D may reduce systemic inflammation and when combined with surgery and early postsurgical rehabilitation, it may decrease the intensity of pain in LBP patients undergoing PLIF. Vitamin D 44-53 lipopolysaccharide binding protein Homo sapiens 198-201 31191300-12 2019 Data indicate that LBP patients undergoing spine surgery should use vitamin D perioperatively as a supplement. Vitamin D 68-77 lipopolysaccharide binding protein Homo sapiens 19-22 31134092-5 2019 The exact association between Vitamin D deficiency and chronic disease conditions remains unclear; however, studies have focused on the mechanism of Vitamin D regulation by assessing the role of the Vitamin D associated genes/proteins such as VDR (Vitamin D receptor), VDBP (Vitamin D Binding protein), CYP27B1 as these are integral parts of the Vitamin D signaling pathway. Vitamin D 149-158 vitamin D receptor Homo sapiens 243-246 31134092-5 2019 The exact association between Vitamin D deficiency and chronic disease conditions remains unclear; however, studies have focused on the mechanism of Vitamin D regulation by assessing the role of the Vitamin D associated genes/proteins such as VDR (Vitamin D receptor), VDBP (Vitamin D Binding protein), CYP27B1 as these are integral parts of the Vitamin D signaling pathway. Vitamin D 149-158 vitamin D receptor Homo sapiens 243-246 31134092-6 2019 VDR is known to regulate the expression of more than 200 genes across a wide array of tissues in the human body and may play a role in controlling the Vitamin D levels. Vitamin D 151-160 vitamin D receptor Homo sapiens 0-3 31134092-7 2019 Moreover, reduced Vitamin D level and downregulation of VDR have been linked to gut dysbiosis, highlighting an intriguing role for the gut microbiome in the Vitamin D metabolism. Vitamin D 157-166 vitamin D receptor Homo sapiens 56-59 31115209-11 2019 Vitamin D levels increased significantly within 5 weeks in the Poly-Nac group (26.6 +- 8.8 ng/mL; p = 0.001) compared to the sham group (3.1 +- 0.9 ng/mL), and the Poly-Nac group to the ImmunoD group (7.0 +- 3.6 ng/mL; p = 0.003). Vitamin D 0-9 NLR family, pyrin domain containing 1A Mus musculus 68-71 31115209-11 2019 Vitamin D levels increased significantly within 5 weeks in the Poly-Nac group (26.6 +- 8.8 ng/mL; p = 0.001) compared to the sham group (3.1 +- 0.9 ng/mL), and the Poly-Nac group to the ImmunoD group (7.0 +- 3.6 ng/mL; p = 0.003). Vitamin D 0-9 NLR family, pyrin domain containing 1A Mus musculus 169-172 30714636-4 2019 Vitamin D exerts its effect through vitamin D receptor and variants in vitamin D receptor (VDR) gene are shown to affect vitamin D signaling. Vitamin D 0-9 vitamin D receptor Homo sapiens 36-54 30714636-4 2019 Vitamin D exerts its effect through vitamin D receptor and variants in vitamin D receptor (VDR) gene are shown to affect vitamin D signaling. Vitamin D 0-9 vitamin D receptor Homo sapiens 71-89 30714636-4 2019 Vitamin D exerts its effect through vitamin D receptor and variants in vitamin D receptor (VDR) gene are shown to affect vitamin D signaling. Vitamin D 0-9 vitamin D receptor Homo sapiens 91-94 30714636-12 2019 In addition, combined analysis of vitamin D levels and VDR mutants revealed association of vitamin D deficiencies and VDR mutants with chronic heart failure. Vitamin D 91-100 vitamin D receptor Homo sapiens 55-58 30714636-12 2019 In addition, combined analysis of vitamin D levels and VDR mutants revealed association of vitamin D deficiencies and VDR mutants with chronic heart failure. Vitamin D 91-100 vitamin D receptor Homo sapiens 118-121 30889441-2 2019 Besides the well-known function of vitamin D, vitamin D receptor is also expressed in brain and is discussed to regulate several genes. Vitamin D 35-44 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 46-64 30654105-0 2019 Mammary-specific ablation of Cyp24a1 inhibits development, reduces proliferation and increases sensitivity to vitamin D. Vitamin D 110-119 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 29-36 30654105-7 2019 In summary, Cyp24a1 within MECs plays an important role in modulating postnatal and pregnancy-associated mammary gland development which provides support for inhibiting CYP24 A1 as a potential approach to activating the vitamin D pathway in breast cancer prevention and therapy. Vitamin D 220-229 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 12-19 30654105-7 2019 In summary, Cyp24a1 within MECs plays an important role in modulating postnatal and pregnancy-associated mammary gland development which provides support for inhibiting CYP24 A1 as a potential approach to activating the vitamin D pathway in breast cancer prevention and therapy. Vitamin D 220-229 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 169-177 30690074-0 2019 Vitamin D (1,25(OH)2D3) induces alpha-1-antitrypsin synthesis by CD4+ T cells, which is required for 1,25(OH)2D3-driven IL-10. Vitamin D 0-9 interleukin 10 Homo sapiens 120-125 30944611-4 2019 The biologically active form of vitamin D/1,25-dihydroxyvitamin D3 acts by binding to a intranuclear receptor; vitamin D receptor (VDR). Vitamin D 32-41 vitamin D receptor Homo sapiens 111-129 30944611-4 2019 The biologically active form of vitamin D/1,25-dihydroxyvitamin D3 acts by binding to a intranuclear receptor; vitamin D receptor (VDR). Vitamin D 32-41 vitamin D receptor Homo sapiens 131-134 31099881-1 2019 The authors" main objective was to demonstrate the confounding effect of combining subgroup data, specifically race, on the prevalence of vitamin D deficiency in adolescent idiopathic scoliosis (AIS). Vitamin D 138-147 IS1 Homo sapiens 195-198 31099881-5 2019 Vitamin D status in girls with AIS was also compared with that in girls without AIS who had a history of fracture and with the medical literature to determine if deficiency in AIS was equal to or greater than other cohorts. Vitamin D 0-9 IS1 Homo sapiens 31-34 31193232-4 2019 We therefore queried whether FoxO3a participates in vitamin D-mediated regulation of calcium transport pathways or matrix calcification, independent of reactive oxygen species (ROS) formation. Vitamin D 52-61 forkhead box O3 Mus musculus 29-35 30157994-0 2019 Therapeutic Efficacy of Vitamin D in Experimental c-MET-beta-Catenin-Driven Hepatocellular Cancer. Vitamin D 24-33 catenin (cadherin associated protein), beta 1 Mus musculus 56-68 30157994-2 2019 Although Wnt/beta-catenin signaling can be targeted by vitamin D, therapeutic use of vitamin D for this purpose is not currently established. Vitamin D 55-64 catenin (cadherin associated protein), beta 1 Mus musculus 13-25 31058117-1 2019 Fibroblast growth factor 23 (FGF 23), an endocrine hormone regulating the homeostasis of phosphate and vitamin D, has been shown to play a role in cardiovascular disease. Vitamin D 103-112 fibroblast growth factor 23 Homo sapiens 0-27 31058117-1 2019 Fibroblast growth factor 23 (FGF 23), an endocrine hormone regulating the homeostasis of phosphate and vitamin D, has been shown to play a role in cardiovascular disease. Vitamin D 103-112 fibroblast growth factor 23 Homo sapiens 29-35 30718230-5 2019 Interfering VDR signals, such as low vitamin D diet and VDR deficiency in donor cells as well as macrophage depletion prevented myelofibrosis in this model. Vitamin D 37-46 vitamin D receptor Homo sapiens 12-15 31089432-1 2019 Introduction: Loss of function mutations of CYP24A1 gene, which is involved in vitamin D catabolism, cause vitamin D-mediated PTH-independent hypercalcemia. Vitamin D 79-88 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 44-51 31089432-1 2019 Introduction: Loss of function mutations of CYP24A1 gene, which is involved in vitamin D catabolism, cause vitamin D-mediated PTH-independent hypercalcemia. Vitamin D 107-116 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 44-51 31089432-8 2019 The panel of vitamin D metabolites evaluated by liquid chromatography showed the typical profile of CYP24A1 mutations, namely, low 24,25(OH)2D3, elevated 25(OH)D3:24,25(OH)2D3 ratio, and undetectable 1,24,25(OH)3D3. Vitamin D 13-22 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 100-107 31089432-11 2019 Conclusion: CYP24A1 gene mutations should be considered in cases of PTH-independent hypercalcemia, once that more common causes (hypercalcemia of malignancy, granulomatous diseases, and vitamin D intoxication) have been ruled out. Vitamin D 186-195 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 12-19 30668811-0 2019 Vitamin D enzymes (CYP27A1, CYP27B1, and CYP24A1) and receptor expression in non-melanoma skin cancer. Vitamin D 0-9 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 41-48 30971944-3 2019 FGF23 is a hormone that is mainly known as the core regulator of phosphate and vitamin D metabolism and it has been recognized as an important regulator of bone mineralization. Vitamin D 79-88 fibroblast growth factor 23 Mus musculus 0-5 30911673-1 2019 Fibroblast growth factor receptor (FGFR) and alpha-Klotho transduce FGF-23 signaling in renal tubules to maintain systemic phosphate/vitamin D homeostasis. Vitamin D 133-142 klotho Mus musculus 51-57 30911673-1 2019 Fibroblast growth factor receptor (FGFR) and alpha-Klotho transduce FGF-23 signaling in renal tubules to maintain systemic phosphate/vitamin D homeostasis. Vitamin D 133-142 fibroblast growth factor 23 Mus musculus 68-74 30963028-8 2019 Results: WES revealed gene variants involved in iron absorption and transport, in the transmembrane protease, serine 6 (TMPRSS6) and transferrin (TF) genes; multiple genetic variants in CUBN, which encodes cubilin (a receptor involved in the absorption of vitamin B12 as well as the reabsorption of transferrin-bound iron and vitamin D in the kidneys); SLC25A37 (involved in iron transport into mitochondria) and CD163 (a scavenger receptor involved in hemorrhage resolution). Vitamin D 326-335 cubilin Homo sapiens 206-213 30909513-2 2019 Initially, it was thought that FGF23 exclusively regulated phosphate and vitamin D metabolism; however, recent research has demonstrated that an excess of FGF23 has other effects that may be detrimental in some cases. Vitamin D 73-82 fibroblast growth factor 23 Homo sapiens 31-36 30976148-1 2019 Purpose: To assess age related manifestations of the femur and tibia in patients with vitamin D-resistant rickets (VDR) and explore causes for recurrent deformity using imaging modalities. Vitamin D 86-95 vitamin D receptor Homo sapiens 115-118 30941131-0 2019 The Association Between Vitamin D and Multiple Sclerosis Risk: 1,25(OH)2D3 Induces Super-Enhancers Bound by VDR. Vitamin D 24-33 vitamin D receptor Homo sapiens 108-111 31011579-2 2019 Biologically active form 1, 25(OH)2D3 of vitamin D can only exert its action after binding its definite vitamin D receptor encoded by VDR gene. Vitamin D 41-50 vitamin D receptor Homo sapiens 104-122 31011579-2 2019 Biologically active form 1, 25(OH)2D3 of vitamin D can only exert its action after binding its definite vitamin D receptor encoded by VDR gene. Vitamin D 41-50 vitamin D receptor Homo sapiens 134-137 31011579-13 2019 In conclusion, serum vitamin D level may be normal among arthritis patients but polymorphism on VDR gene restricts vitamin D to perform its anti-inflammatory function by altering the 1, 25(OH)2 D3 binding sites. Vitamin D 21-30 vitamin D receptor Homo sapiens 96-99 31011579-13 2019 In conclusion, serum vitamin D level may be normal among arthritis patients but polymorphism on VDR gene restricts vitamin D to perform its anti-inflammatory function by altering the 1, 25(OH)2 D3 binding sites. Vitamin D 115-124 vitamin D receptor Homo sapiens 96-99 30874583-4 2019 In contrast to cultivation in conventional tissue culture settings, on-chip cultivation of HepG2 and RPTEC cells in interconnected chambers, used to mimic the liver and kidneys, respectively, resulted in the enhanced expression of vitamin D metabolizing enzymes (CYP2R1, CYP27B1 and CYP24A1). Vitamin D 231-240 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 283-290 30845908-3 2019 Vitamin D has been shown to exert its effects via a nuclear vitamin D receptor (VDR) and therefore, VDR gene may be considered a candidate for T1DM susceptibility. Vitamin D 0-9 vitamin D receptor Homo sapiens 60-78 30845908-3 2019 Vitamin D has been shown to exert its effects via a nuclear vitamin D receptor (VDR) and therefore, VDR gene may be considered a candidate for T1DM susceptibility. Vitamin D 0-9 vitamin D receptor Homo sapiens 80-83 30845908-3 2019 Vitamin D has been shown to exert its effects via a nuclear vitamin D receptor (VDR) and therefore, VDR gene may be considered a candidate for T1DM susceptibility. Vitamin D 0-9 vitamin D receptor Homo sapiens 100-103 30890957-3 2019 Moreover, the nearly ubiquitous expression of VDR enabled vitamin D to acquire additional physiological functions, such as the support of the innate immune system in its defense against microbes. Vitamin D 58-67 vitamin D receptor Homo sapiens 46-49 30832722-3 2019 This study was designed to examine the effects on vitamin D supplementation on serum levels of vitamin D receptor (VDR), fibrogenic factors, and fibrogenic microRNAs (MiR) in NAFLD patients. Vitamin D 50-59 vitamin D receptor Homo sapiens 95-113 30832722-3 2019 This study was designed to examine the effects on vitamin D supplementation on serum levels of vitamin D receptor (VDR), fibrogenic factors, and fibrogenic microRNAs (MiR) in NAFLD patients. Vitamin D 50-59 vitamin D receptor Homo sapiens 115-118 30832722-9 2019 DISCUSSION: This is the first randomized controlled trial that will determine the effect of vitamin D supplementation on serum levels of VDR, fibrogenic factors, and fibrogenic MiRs in NAFLD patients. Vitamin D 92-101 vitamin D receptor Homo sapiens 137-140 30003595-1 2019 AIM: Vitamin D stimulates production of the endogenous antimicrobial peptides cathelicidin and beta-defensin-2, which are expressed in the urinary tract. Vitamin D 5-14 defensin beta 4B Homo sapiens 95-110 30984586-1 2019 Background: Vitamin D has stimulatory and protective effects on melanocytes and acts through its nuclear vitamin D receptor (VDR) on target cells. Vitamin D 12-21 vitamin D receptor Homo sapiens 105-123 30984586-1 2019 Background: Vitamin D has stimulatory and protective effects on melanocytes and acts through its nuclear vitamin D receptor (VDR) on target cells. Vitamin D 12-21 vitamin D receptor Homo sapiens 125-128 30984586-13 2019 Conclusion: The single nucleotide gene polymorphisms of various VDR genes as found in the cases might lead to vitamin D deficiency, due to VDR dysfunction, which in turn could increase the susceptibility to develop vitiligo. Vitamin D 110-119 vitamin D receptor Homo sapiens 64-67 30983779-1 2019 Background: Vitamin D, an important hormone required by the body, exerts its biological effects through Vitamin D receptors (VDRs) present on target cells. Vitamin D 12-21 vitamin D receptor Homo sapiens 104-123 30983779-15 2019 Conclusions: The study determined Vitamin D Receptors (VDR) in PDL tissue after supplementation of Vitamin D. Vitamin D 34-43 vitamin D receptor Homo sapiens 55-58 30796319-1 2019 Emerging evidence suggests a role for 7-dehydrocholesterol reductase (DHCR7) in the crosstalk between cholesterol and vitamin D. Vitamin D 118-127 7-dehydrocholesterol reductase Homo sapiens 38-68 30796319-1 2019 Emerging evidence suggests a role for 7-dehydrocholesterol reductase (DHCR7) in the crosstalk between cholesterol and vitamin D. Vitamin D 118-127 7-dehydrocholesterol reductase Homo sapiens 70-75 30796319-2 2019 Our aim was to evaluate the impact of vitamin D-related polymorphisms and DHCR7 levels in the association between vitamin D deficiency and altered lipid profile in rheumatoid arthritis (RA). Vitamin D 114-123 7-dehydrocholesterol reductase Homo sapiens 74-79 30778159-9 2019 Although 1,25(OH)2D and 24,25(OH)2D are decreased in CKD patient serum, our findings suggest that PTH and FGF23 retain their effects to regulate vitamin D metabolism even in the kidneys of these patients, while production of 1,25(OH)2D and 24,25(OH)2D from 25(OH)D is restricted due to either impairment of megalin-mediated reabsorption of the 25(OH)D-DBP complex or reduced renal mass. Vitamin D 145-154 fibroblast growth factor 23 Homo sapiens 106-111 30317548-3 2019 The aim of this study was to establish whether high-dose vitamin D supplementation reduces serum levels of NFL. Vitamin D 57-66 neurofilament light chain Homo sapiens 107-110 30317548-8 2019 In the subgroup of patients not receiving disease-modifying therapy, NFL decreased by 30.9% to week 48% and 32.6% to week 96 from baseline in the vitamin D group as compared to the placebo group (P = 0.06 for both time points). Vitamin D 146-155 neurofilament light chain Homo sapiens 69-72 30578920-0 2019 Glutathione deficiency alters the vitamin D-metabolizing enzymes CYP27B1 and CYP24A1 in human renal proximal tubule epithelial cells and kidney of HFD-fed mice. Vitamin D 34-43 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 77-84 30631035-0 2019 Acidosis enhances the self-renewal and mitochondrial respiration of stem cell-like glioma cells through CYP24A1-mediated reduction of vitamin D. Vitamin D 134-143 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 104-111 30631035-5 2019 Our study indicates that the acidosis-CYP24A1-vitamin D pathway may be a key regulator of the cancer stem cell phenotype in malignant glioma and point out the potential value for the utilization of vitamin D to target cancer stem cells and to restrain the growth of malignant glioma in the future. Vitamin D 46-55 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 38-45 30631035-5 2019 Our study indicates that the acidosis-CYP24A1-vitamin D pathway may be a key regulator of the cancer stem cell phenotype in malignant glioma and point out the potential value for the utilization of vitamin D to target cancer stem cells and to restrain the growth of malignant glioma in the future. Vitamin D 198-207 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 38-45 30133162-7 2019 Endotoxaemia augmented plasma levels of PTH and affected the fibroblast growth factor 23 (FGF23)-klotho-vitamin D axis by increasing plasma levels of FGF23 and downregulation of renal klotho expression. Vitamin D 104-113 fibroblast growth factor 23 Mus musculus 61-88 30133162-7 2019 Endotoxaemia augmented plasma levels of PTH and affected the fibroblast growth factor 23 (FGF23)-klotho-vitamin D axis by increasing plasma levels of FGF23 and downregulation of renal klotho expression. Vitamin D 104-113 fibroblast growth factor 23 Mus musculus 90-95 31257315-1 2019 To develop potent ligands for the vitamin D receptor (VDR), we designed and synthesized a series of vitamin D analogues with and without 22-alkyl substituents. Vitamin D 34-43 vitamin D receptor Homo sapiens 54-57 30192652-4 2019 We selected four single nucleotide polymorphisms (SNPs; rs1993116 and rs10741657 of CYP2R1; rs4809957 and rs6068816 of CYP24A1) for genotyping in 525 control subjects and 324 hypertensive patients, and detected vitamin D levels in blood in subsets of these groups. Vitamin D 211-220 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 119-126 30395535-4 2018 The biological activity of vitamin D occurs via two pathways: non-genomic and genomic responses, both of which involve binding of 1,25-dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D binding to the vitamin D receptor (VDR). Vitamin D 27-36 vitamin D receptor Homo sapiens 218-236 30395535-4 2018 The biological activity of vitamin D occurs via two pathways: non-genomic and genomic responses, both of which involve binding of 1,25-dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D binding to the vitamin D receptor (VDR). Vitamin D 27-36 vitamin D receptor Homo sapiens 238-241 30395535-4 2018 The biological activity of vitamin D occurs via two pathways: non-genomic and genomic responses, both of which involve binding of 1,25-dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D binding to the vitamin D receptor (VDR). Vitamin D 144-153 vitamin D receptor Homo sapiens 218-236 30395535-4 2018 The biological activity of vitamin D occurs via two pathways: non-genomic and genomic responses, both of which involve binding of 1,25-dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D binding to the vitamin D receptor (VDR). Vitamin D 144-153 vitamin D receptor Homo sapiens 238-241 30373854-10 2018 Taken together, our data suggest that Klotho deficiency causes thymic involution via systemic effects that include high active vitamin D levels. Vitamin D 127-136 klotho Mus musculus 38-44 29972092-3 2018 Among these, vitamin D and hence its receptor (VDR) gene polymorphisms have gained much interest; however, the results are still controversial. Vitamin D 13-22 vitamin D receptor Homo sapiens 47-50 29481636-7 2018 Vitamin D supplementation further increased FGF23 in 4C but not in ERGO patients. Vitamin D 0-9 fibroblast growth factor 23 Homo sapiens 44-49 29481636-8 2018 Serum Klotho and sclerostin normalized with vitamin D supplementation in ERGO but remained unchanged in 4C patients. Vitamin D 44-53 klotho Homo sapiens 6-12 29481636-10 2018 In the total cohort, significant effects of vitamin D supplementation were noted for Klotho at eGFR 40-70 mL/min/1.73 m2. Vitamin D 44-53 klotho Homo sapiens 85-91 29481636-10 2018 In the total cohort, significant effects of vitamin D supplementation were noted for Klotho at eGFR 40-70 mL/min/1.73 m2. Vitamin D 44-53 thrombopoietin Mus musculus 106-108 29481636-11 2018 Conclusions: Vitamin D supplementation normalized Klotho and sclerostin in children with mild to moderate CKD but further increased FGF23 in advanced CKD. Vitamin D 13-22 klotho Homo sapiens 50-56 29481636-11 2018 Conclusions: Vitamin D supplementation normalized Klotho and sclerostin in children with mild to moderate CKD but further increased FGF23 in advanced CKD. Vitamin D 13-22 fibroblast growth factor 23 Homo sapiens 132-137 30555810-2 2018 Homozygous or heterozygous mutations in the vitamin D receptor (VDR) gene leading to complete or partial target organ resistance to the action of 1alpha, 25-dihydroxyvitamin D3 (the active form of vitamin D) are responsible for HVDRR. Vitamin D 44-53 vitamin D receptor Homo sapiens 64-67 30484666-1 2018 Resistance to vitamin D has been known for decades as vitamin D resistant rickets, caused by mutations of the gene encoding for vitamin D receptor (VDR). Vitamin D 14-23 vitamin D receptor Homo sapiens 128-146 30484666-1 2018 Resistance to vitamin D has been known for decades as vitamin D resistant rickets, caused by mutations of the gene encoding for vitamin D receptor (VDR). Vitamin D 14-23 vitamin D receptor Homo sapiens 148-151 30484666-1 2018 Resistance to vitamin D has been known for decades as vitamin D resistant rickets, caused by mutations of the gene encoding for vitamin D receptor (VDR). Vitamin D 54-63 vitamin D receptor Homo sapiens 128-146 30484666-1 2018 Resistance to vitamin D has been known for decades as vitamin D resistant rickets, caused by mutations of the gene encoding for vitamin D receptor (VDR). Vitamin D 54-63 vitamin D receptor Homo sapiens 148-151 30408071-8 2018 Maternal vitamin D deficiency was found in all pathological pregnancies combined with significantly reduced staining levels of placental VDR in IUGR. Vitamin D 9-18 vitamin D receptor Homo sapiens 137-140 30408071-9 2018 Finally, there was a strong and significant negative correlation between the survival capacity (MAP1LC3B/BECN1) and both maternal vitamin D and placental VDR in the preeclampsia groups. Vitamin D 130-139 beclin 1 Homo sapiens 105-110 30386121-10 2018 Moreover, the changes in IL-17A over the treatment period were significantly associated with vitamin D changes (beta=-0.04, SE=0.02, P=0.046). Vitamin D 93-102 interleukin 17A Homo sapiens 25-31 30257386-0 2018 Astemizole promotes the anti-tumor effect of vitamin D through inhibiting miR-125a-5p-meidated regulation of VDR in HCC. Vitamin D 45-54 vitamin D receptor Homo sapiens 109-112 30257386-7 2018 Downregulation of VDR significantly inhibited the synergistic effect of Vitamin D and astemizole on HCC cell viability, proliferation, apoptosis, migration and invasion. Vitamin D 72-81 vitamin D receptor Homo sapiens 18-21 30257386-13 2018 We identified that inhibition of miR-125a-5p and subsequent upregulation of VDR was involved in astemizole-induced enhancement of the anti-tumor effect of Vitamin D in HCC. Vitamin D 155-164 vitamin D receptor Homo sapiens 76-79 30455079-17 2018 Overall, our results suggest that activating the vitamin D pathway could be a mechanism to decrease STAT1 and 3 activation and inflammatory cytokine output in NK-LGLL patients. Vitamin D 49-58 signal transducer and activator of transcription 1 Homo sapiens 100-111 29660161-1 2018 BACKGROUND: Fibroblast growth factor-23 (FGF-23) and klotho are key regulators of vitamin D and parathyroid hormone (PTH) synthesis as well as phosphorus and calcium homeostasis; however, information on the FGF-23/klotho axis in healthy and hospitalised foals is lacking. Vitamin D 82-91 fibroblast growth factor 23 Homo sapiens 12-39 29660161-1 2018 BACKGROUND: Fibroblast growth factor-23 (FGF-23) and klotho are key regulators of vitamin D and parathyroid hormone (PTH) synthesis as well as phosphorus and calcium homeostasis; however, information on the FGF-23/klotho axis in healthy and hospitalised foals is lacking. Vitamin D 82-91 fibroblast growth factor 23 Homo sapiens 41-47 29660161-1 2018 BACKGROUND: Fibroblast growth factor-23 (FGF-23) and klotho are key regulators of vitamin D and parathyroid hormone (PTH) synthesis as well as phosphorus and calcium homeostasis; however, information on the FGF-23/klotho axis in healthy and hospitalised foals is lacking. Vitamin D 82-91 klotho Homo sapiens 53-59 29377305-1 2018 Calcium binding protein calbindin-D28K (CaBP28K) mediates the relationship between vitamin D and calcium, but its mechanism remains unclear during bone formation. Vitamin D 83-92 calbindin 1 Mus musculus 24-28 30217676-1 2018 Fibroblast growth factor (FGF) 23 is a bone-derived phosphotropic hormone that regulates phosphate and vitamin D metabolism. Vitamin D 103-112 fibroblast growth factor 23 Homo sapiens 0-33 30886976-0 2018 Vitamin D in individuals before onset of rheumatoid arthritis - relation to vitamin D binding protein and its associated genetic variants. Vitamin D 0-9 GC vitamin D binding protein Homo sapiens 76-101 30410834-3 2018 Due to the close association of vitamin D with the brain, it has been found that in the pathophysiology of several neuropsychiatric disorders vitamin D receptor (VDR) polymorphism plays a significant role. Vitamin D 32-41 vitamin D receptor Homo sapiens 142-160 30410834-3 2018 Due to the close association of vitamin D with the brain, it has been found that in the pathophysiology of several neuropsychiatric disorders vitamin D receptor (VDR) polymorphism plays a significant role. Vitamin D 32-41 vitamin D receptor Homo sapiens 162-165 30157189-8 2018 Vitamin D increased HBEC expression of the antioxidant pathway gene G6PD, increased the ratio of reduced to oxidised glutathione, and in PM-stimulated cultures decreased the formation of 8-isoprostane. Vitamin D 0-9 glucose-6-phosphate dehydrogenase Homo sapiens 68-72 30157189-9 2018 Pre-treatment with vitamin D decreased CXCL8 and further decreased IL-6 production in PM-stimulated cultures, an effect abrogated by inhibition of G6PD with DHEA, supporting a role for this pathway in the anti-inflammatory actions of vitamin D. Vitamin D 19-28 glucose-6-phosphate dehydrogenase Homo sapiens 147-151 30157189-9 2018 Pre-treatment with vitamin D decreased CXCL8 and further decreased IL-6 production in PM-stimulated cultures, an effect abrogated by inhibition of G6PD with DHEA, supporting a role for this pathway in the anti-inflammatory actions of vitamin D. Vitamin D 234-243 glucose-6-phosphate dehydrogenase Homo sapiens 147-151 30150596-0 2018 Association between Vitamin D Deficiency and Single Nucleotide Polymorphisms in the Vitamin D Receptor and GC Genes and Analysis of Their Distribution in Mexican Postmenopausal Women. Vitamin D 20-29 vitamin D receptor Homo sapiens 84-102 30197603-1 2018 Calcitriol, the bioactive metabolite of vitamin D, interacts with the ubiquitously expressed nuclear vitamin D receptor (VDR) to induce genomic effects, but it can also elicit rapid responses via membrane-associated VDR through mechanisms that are poorly understood. Vitamin D 40-49 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 101-119 30197603-1 2018 Calcitriol, the bioactive metabolite of vitamin D, interacts with the ubiquitously expressed nuclear vitamin D receptor (VDR) to induce genomic effects, but it can also elicit rapid responses via membrane-associated VDR through mechanisms that are poorly understood. Vitamin D 40-49 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 121-124 30197603-1 2018 Calcitriol, the bioactive metabolite of vitamin D, interacts with the ubiquitously expressed nuclear vitamin D receptor (VDR) to induce genomic effects, but it can also elicit rapid responses via membrane-associated VDR through mechanisms that are poorly understood. Vitamin D 40-49 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 216-219 30142216-4 2018 Therefore, we investigated the relationship between vitamin D levels and brain phenotypes in psychotic disorders, and assessed possible interactions with genetic variants in vitamin D receptor (VDR) and other genetic variants that play a role in vitamin D levels in the body. Vitamin D 174-183 vitamin D receptor Homo sapiens 194-197 30138371-3 2018 Therefore, we wanted to search for differences in expression of genes involved in the vitamin D receptor (VDR) activation pathway and genes that are known to alter upon vitamin D stimulation, in the aortic adventitia of CAD patients with and without RA. Vitamin D 86-95 vitamin D receptor Homo sapiens 106-109 30210711-7 2018 In vivo, a vitamin D-deficiency VDR-/- and WT mouse model was established and the mice were vaccinated with BCG. Vitamin D 11-20 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 32-35 29575677-1 2018 The active form of vitamin D (1alpha,25-dihydroxyvitamin D) acts as a steroid hormone and binds to the vitamin D receptor. Vitamin D 19-28 vitamin D receptor Homo sapiens 103-121 29402723-0 2018 Reduction of respiratory infections in asthma patients supplemented with vitamin D is related to increased serum IL-10 and IFNgamma levels and cathelicidin expression. Vitamin D 73-82 interleukin 10 Homo sapiens 113-118 29402723-8 2018 RESULTS: Serum levels of IL-10 and IFNgamma increased significantly in the group of patients with vitamin D supplementation, while IL-5, IL-9, and IL-13 decreased significantly. Vitamin D 98-107 interleukin 10 Homo sapiens 25-30 29533153-3 2018 Vitamin D receptor enzymes that metabolize vitamin D are expressed in both central and peripheral reproductive organs. Vitamin D 43-52 vitamin D receptor Homo sapiens 0-18 30202762-1 2018 Objectives: To investigate if vitamin D receptor (VDR) gene polymorphisms and circulating vitamin D levels are associated with pelvic floor disorders (PFDs). Vitamin D 30-39 vitamin D receptor Homo sapiens 50-53 30202762-8 2018 Taken together, our observations suggest that vitamin D levels could be associated with PFDs and that 2 polymorphisms (i.e., ApaI and BsmI) in the VDR gene may contribute to an increased prevalence of PFDs in women with insufficient levels of vitamin D. Vitamin D 46-55 vitamin D receptor Homo sapiens 147-150 30202762-8 2018 Taken together, our observations suggest that vitamin D levels could be associated with PFDs and that 2 polymorphisms (i.e., ApaI and BsmI) in the VDR gene may contribute to an increased prevalence of PFDs in women with insufficient levels of vitamin D. Vitamin D 243-252 vitamin D receptor Homo sapiens 147-150 30065237-2 2018 Vitamin D helps the regulation of neurotrophin, neural differentiation, and maturation, through the control operation of growing factors synthesis (i.e., neural growth factor [NGF] and glial cell line-derived growth factor (GDNF), the trafficking of the septohippocampal pathway, and the control of the synthesis process of different neuromodulators (such as acetylcholine [Ach], dopamine [DA], and gamma-aminobutyric [GABA]). Vitamin D 0-9 brain derived neurotrophic factor Homo sapiens 34-46 29936834-1 2018 We designed and synthesized vitamin D analogues with an electrophile as covalent modifiers for the vitamin D receptor (VDR). Vitamin D 28-37 vitamin D receptor Homo sapiens 99-117 29936834-1 2018 We designed and synthesized vitamin D analogues with an electrophile as covalent modifiers for the vitamin D receptor (VDR). Vitamin D 28-37 vitamin D receptor Homo sapiens 119-122 29936834-2 2018 Novel vitamin D analogues 1-4 have an electrophilic enone group at the side chain for conjugate addition to His301 or His393 in the VDR. Vitamin D 6-15 vitamin D receptor Homo sapiens 132-135 29936834-9 2018 We successfully synthesized vitamin D analogues that form a covalent bond with VDR-LBD. Vitamin D 28-37 vitamin D receptor Homo sapiens 79-82 29751971-11 2018 Real-time PCR analyses of kidney CYP27B1 and CYP24A1 expression in wild type mice showed that exogenous antidiuretic hormone blocked FGF23"s actions on these vitamin D activating or inactivating enzymes. Vitamin D 158-167 fibroblast growth factor 23 Mus musculus 133-138 30066819-1 2018 OBJECTIVE: To verify the relationship between polymorphisms of the vitamin D receptor gene (VDR), clinical findings, and serum vitamin D (VD) levels in asthmatics. Vitamin D 67-76 vitamin D receptor Homo sapiens 92-95 29420306-7 2018 Results While comparing the results of medium-high dose (5 mug/kg) and high dose (10 mug/kg) vitamin D administration to that of the control group, it was observed that serum antioxidant status and annexin V levels decreased and glomerular mesenchial matrix ratio increased in kidney (p<0.05). Vitamin D 93-102 annexin A5 Mus musculus 198-207 29977597-1 2018 Vitamin D, a fat-soluble prohormone, has wide-ranging roles in the regulation of many physiological processes through their interactions with the vitamin D receptors (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 146-165 29977597-1 2018 Vitamin D, a fat-soluble prohormone, has wide-ranging roles in the regulation of many physiological processes through their interactions with the vitamin D receptors (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 167-170 29899561-2 2018 In this study, we found that at a physiological concentration, 25(OH)D3 (25D3), the precursor of 1,25D3 and an inactive form of vitamin D because of its much weaker binding activity to the vitamin D receptor (VDR) compared with 1,25D3, had a gene expression profile similar to that of 1,25D3 in prostate cancer LNCaP cells. Vitamin D 128-137 vitamin D receptor Homo sapiens 189-207 29788141-1 2018 Background: Vitamin D signaling modulates inflammation through the vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 67-85 29788141-1 2018 Background: Vitamin D signaling modulates inflammation through the vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 87-90 29874855-1 2018 Vitamin D receptor (VDR) mediates many genomic and non-genomic effects of vitamin D. Vitamin D 74-83 vitamin D receptor Homo sapiens 0-18 29874855-1 2018 Vitamin D receptor (VDR) mediates many genomic and non-genomic effects of vitamin D. Vitamin D 74-83 vitamin D receptor Homo sapiens 20-23 29922235-1 2018 Vitamin D receptor (VDR) is one of the main mediators of vitamin D biological activity. Vitamin D 57-66 vitamin D receptor Homo sapiens 0-18 29922235-1 2018 Vitamin D receptor (VDR) is one of the main mediators of vitamin D biological activity. Vitamin D 57-66 vitamin D receptor Homo sapiens 20-23 29726119-7 2018 Additionally, genotyping of 296 SNPs in the same subjects resulted in findings that 27 SNPs, predominantly in CYP24A1 and VDR genes, were significantly associated with lung cancer status, affected mRNA expression, and modulated vitamin D levels. Vitamin D 228-237 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 110-117 29726119-7 2018 Additionally, genotyping of 296 SNPs in the same subjects resulted in findings that 27 SNPs, predominantly in CYP24A1 and VDR genes, were significantly associated with lung cancer status, affected mRNA expression, and modulated vitamin D levels. Vitamin D 228-237 vitamin D receptor Homo sapiens 122-125 29217467-5 2018 In the circulation, vitamin D - like other steroid hormones - is bound tightly to a special carrier - vitamin D-binding protein (DBP). Vitamin D 20-29 GC vitamin D binding protein Homo sapiens 102-127 29519954-2 2018 We sought to determine whether elevated plasma levels of the osteocyte-derived, vitamin D-regulating hormone, fibroblast growth factor 23 (FGF23), are prospectively associated with death in critically ill patients with AKI requiring RRT, and in a general cohort of critically ill patients with and without AKI. Vitamin D 80-89 fibroblast growth factor 23 Homo sapiens 110-137 29519954-2 2018 We sought to determine whether elevated plasma levels of the osteocyte-derived, vitamin D-regulating hormone, fibroblast growth factor 23 (FGF23), are prospectively associated with death in critically ill patients with AKI requiring RRT, and in a general cohort of critically ill patients with and without AKI. Vitamin D 80-89 fibroblast growth factor 23 Homo sapiens 139-144 29782293-0 2018 Mycosis Fungoides and Vitamin D Status: Analyses of Serum 25-Hydroxyvitamin D Levels and Single Nucleotide Polymorphisms in the Vitamin D Receptor Gene. Vitamin D 22-31 vitamin D receptor Homo sapiens 128-146 28673024-8 2018 A CYP3A43 genotype, previously implicated in cancer, is strongly associated with biomarkers of vitamin D metabolism. Vitamin D 95-104 cytochrome P450 family 3 subfamily A member 43 Homo sapiens 2-9 28994020-3 2018 Multiple factors are linked to vitamin D status, such as Fitzpatrick skin type, sex, body mass index, physical activity, alcohol intake, and vitamin D receptor polymorphisms. Vitamin D 31-40 vitamin D receptor Homo sapiens 141-159 29392411-0 2018 Investigating the roles of regulatory T cells, mast cells and interleukin-9 in the control of skin inflammation by vitamin D. Vitamin D 115-124 interleukin 9 Mus musculus 62-75 28892641-3 2018 Vitamin D binding protein (VDBP) is the primary vitamin D carrier and many of its genetic polymorphisms are able to induce the expression of proteins with different affinities for the vitamin, which in turn might affect its serum levels and CAD incidence. Vitamin D 48-57 GC vitamin D binding protein Homo sapiens 0-25 28892641-3 2018 Vitamin D binding protein (VDBP) is the primary vitamin D carrier and many of its genetic polymorphisms are able to induce the expression of proteins with different affinities for the vitamin, which in turn might affect its serum levels and CAD incidence. Vitamin D 48-57 GC vitamin D binding protein Homo sapiens 27-31 29458003-0 2018 FGF 23, PTH and vitamin D status in end stage renal disease patients affected by VDR FokI and BsmI variants. Vitamin D 16-25 vitamin D receptor Homo sapiens 81-84 29343609-0 2018 Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in Humans. Vitamin D 119-128 sulfotransferase family 2A member 1 Homo sapiens 18-38 29343609-6 2018 Further analysis revealed a significant association between a common single nucleotide variant within intron 1 of SULT2A1 (rs296361; minor allele frequency = 15% in whites) and liver cytosolic SULT2A1 content as well as 25OHD3-3-O-sulfate formation rate, suggesting that variation in the SULT2A1 gene contributes importantly to interindividual differences in vitamin D homeostasis. Vitamin D 359-368 sulfotransferase family 2A member 1 Homo sapiens 114-121 29679282-3 2018 Inhibition of FGF23 by burosumab results in increased renal phosphate reabsorption and increased serum levels of phosphorus and active vitamin D. Vitamin D 135-144 fibroblast growth factor 23 Homo sapiens 14-19 29196501-0 2018 Vitamin D binding protein rs7041 genotype alters vitamin D metabolism in pregnant women. Vitamin D 49-58 GC vitamin D binding protein Homo sapiens 0-25 29196501-9 2018 Vitamin D binding protein rs7041 genotype alters vitamin D metabolism in pregnant women. Vitamin D 49-58 GC vitamin D binding protein Homo sapiens 0-25 29435763-1 2018 Vitamin D, synthesized in the skin or absorbed from the diet, undergoes multi-step enzymatic conversion to its active form, 1,25-dihydroxy vitamin D [1,25(OH)2D], followed by interaction with the vitamin D receptor (VDR), to modulate target gene expression. Vitamin D 0-9 vitamin D receptor Homo sapiens 196-214 29435763-1 2018 Vitamin D, synthesized in the skin or absorbed from the diet, undergoes multi-step enzymatic conversion to its active form, 1,25-dihydroxy vitamin D [1,25(OH)2D], followed by interaction with the vitamin D receptor (VDR), to modulate target gene expression. Vitamin D 0-9 vitamin D receptor Homo sapiens 216-219 29435763-9 2018 These actions demonstrate the critical role of vitamin D in regulating skeletal homeostasis both indirectly and directly via the 1,25(OH)2D/VDR system. Vitamin D 47-56 vitamin D receptor Homo sapiens 140-143 29428204-2 2018 And 24-hydroxylase encoded by CYP24A1 is the very enzyme that degrades the active vitamin D metabolite. Vitamin D 82-91 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 30-37 29549592-5 2018 In the present study, we evaluated vitamin D serum concentration as well as expression of vitamin D receptor (VDR) gene and genes encoding for vitamin D activating enzyme 1-alpha-hydroxylase (CYP27B1) and deactivating enzyme 24-hyroxylase (CYP24A1) in epileptic patients compared with healthy individuals. Vitamin D 90-99 vitamin D receptor Homo sapiens 110-113 29229305-0 2018 Expression and shedding of CD44 in the endometrium of women with endometriosis and modulating effects of vitamin D: A randomized exploratory trial. Vitamin D 105-114 CD44 molecule (Indian blood group) Homo sapiens 27-31 29425808-4 2018 The resistance to CYP24A1-dependent metabolism could be an important property of vitamin D analogs in prolonging their biological effects. Vitamin D 81-90 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 18-25 28087977-9 2018 The reduced levels of Vitamin D, and urinary losses may contribute to lower levels of FGF23 in NS. Vitamin D 22-31 fibroblast growth factor 23 Homo sapiens 86-91 29388046-3 2018 METHOD: We identified all studies that assessed the changes of TPO-Ab and Tg-Ab in patients with AIT under the treatment of vitamin D from PubMed, Embase, The Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang, and VIP Database. Vitamin D 124-133 thyroid peroxidase Homo sapiens 63-66 29388046-5 2018 The results showed that Vitamin D supplementation significantly dropped TPO-Ab titers [three studies, random effects standardized mean difference (SMD): -1.11, 95% CI -1.52 to -0.70, P < 0.01] at six months, but not at no more than 3 months [random effects SMD: -0.12, 95% CI: -0.69 to 0.44, P = 0.67]. Vitamin D 24-33 thyroid peroxidase Homo sapiens 72-75 29388046-8 2018 CONCLUSIONS: The current evidence suggests that vitamin D supplementation could decrease serum TPO-Ab and Tg-Ab titers of patients with AIT in the short-term (about six months). Vitamin D 48-57 thyroid peroxidase Homo sapiens 95-98 28004271-0 2018 Maternal vitamin D deficiency during pregnancy affects expression of adipogenic-regulating genes peroxisome proliferator-activated receptor gamma (PPARgamma) and vitamin D receptor (VDR) in lean male mice offspring. Vitamin D 9-18 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 162-180 28004271-0 2018 Maternal vitamin D deficiency during pregnancy affects expression of adipogenic-regulating genes peroxisome proliferator-activated receptor gamma (PPARgamma) and vitamin D receptor (VDR) in lean male mice offspring. Vitamin D 9-18 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 182-185 28008453-0 2018 Association of VDBP and CYP2R1 gene polymorphisms with vitamin D status in women with polycystic ovarian syndrome: a north Indian study. Vitamin D 55-64 GC vitamin D binding protein Homo sapiens 15-19 28008453-10 2018 CONCLUSIONS: The present study shows that the GT allele of VDBP SNP rs7041, the VDBP allelic combination (GC1F/1F), and GA allele of CYP2R1 SNP rs2060793 in vitamin D deficient women increase the risk of PCOS. Vitamin D 157-166 GC vitamin D binding protein Homo sapiens 59-63 29456680-11 2018 The results showed that children with bronchial asthma are often accompanied by different degrees of changes in VDR gene polymorphism, which is negatively correlated with the severity of asthma, so vitamin D should be strengthened to ameliorate the prognosis of children. Vitamin D 198-207 vitamin D receptor Homo sapiens 112-115 28870465-0 2018 Inhibition of IL-17-committed T cells in a murine psoriasis model by a vitamin D analogue. Vitamin D 71-80 interleukin 17A Mus musculus 14-19 28870465-2 2018 OBJECTIVE: We sought to clarify whether and how the topical vitamin D analogue calcipotriol (CAL) controls the IL-17A-mediated pathogenesis of murine psoriasis-like dermatitis in vivo. Vitamin D 60-69 interleukin 17A Mus musculus 111-117 28874334-10 2018 Further identification of as many disease-causing mutations in the CYP24A1 gene as possible can help identification of predisposed individuals in whom vitamin-D supplementation should be reconsidered. Vitamin D 151-160 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 67-74 29416576-0 2018 Association of SIRT-1 Gene Polymorphism and Vitamin D Level in Egyptian Patients With Rheumatoid Arthritis. Vitamin D 44-53 sirtuin 1 Homo sapiens 15-21 29416576-1 2018 Background: We investigated SIRT-1 genetic variant and its association with vitamin D level in Egyptian patients with rheumatoid arthritis (RA). Vitamin D 76-85 sirtuin 1 Homo sapiens 28-34 29290431-6 2018 Immune activation of the intracrine vitamin D pathway, including induction of inducible nitric oxide synthase and beta-defensin gene expression by 1,25(OH)2D3, has been documented in the mammary glands of lactating dairy cows. Vitamin D 36-45 nitric oxide synthase 2 Bos taurus 78-109 28795342-0 2018 Effect of Cholecalciferol therapy on serum FGF23 in vitamin D deficient patients: a randomized clinical trial. Vitamin D 52-61 fibroblast growth factor 23 Homo sapiens 43-48 28795342-2 2018 However, the effect of Cholecalciferol therapy on FGF23 serum level in patients with vitamin D deficiency has not been studied, yet. Vitamin D 85-94 fibroblast growth factor 23 Homo sapiens 50-55 28795342-6 2018 However, delta values of serum 25(OH)D3, 1,25(OH)2D3 and FGF23 in vitamin D treated group were more than the placebo-treated ones (P < 0.001, P = 0.002, and P = 0.04, respectively). Vitamin D 66-75 fibroblast growth factor 23 Homo sapiens 57-62 29433089-2 2018 These physiological actions caused by vitamin D are triggered by the specific binding of vitamin D to its receptor (VDR). Vitamin D 38-47 vitamin D receptor Homo sapiens 116-119 29433089-2 2018 These physiological actions caused by vitamin D are triggered by the specific binding of vitamin D to its receptor (VDR). Vitamin D 89-98 vitamin D receptor Homo sapiens 116-119 29433089-3 2018 Here we investigated the specific interactions and binding affinities between VDR and vitamin D derivatives, using ab initio fragment molecular orbital (FMO) calculations. Vitamin D 86-95 vitamin D receptor Homo sapiens 78-81 28602960-3 2018 Mutations in human VDR (hVDR) cause hereditary vitamin D resistant rickets, a genetic syndrome characterized by hypocalcemia, hyperparathyroidism and rickets resulting from dysregulation of mineral homeostasis. Vitamin D 47-56 vitamin D receptor Homo sapiens 19-22 28710021-4 2018 Here we review our recent findings in this area, including our data revealing that reduction of the expression of the vitamin D receptor (Vdr) within BCa cells accelerates primary tumor growth and enables the development of metastases, demonstrating a tumor autonomous effect of vitamin D signaling to suppress BCa metastases. Vitamin D 118-127 vitamin D receptor Homo sapiens 138-141 28734987-3 2018 Vitamin D binding protein (DBP) is the main carrier of vitamin D in circulation and plays an important role in regulating vitamin D concentration and bioavailability for target tissues. Vitamin D 55-64 GC vitamin D binding protein Homo sapiens 0-25 28734987-3 2018 Vitamin D binding protein (DBP) is the main carrier of vitamin D in circulation and plays an important role in regulating vitamin D concentration and bioavailability for target tissues. Vitamin D 122-131 GC vitamin D binding protein Homo sapiens 0-25 28765041-2 2018 The role of vitamin D in osteoclasts through direct 1,25D-VDR signalling is less well known. Vitamin D 12-21 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 58-61 28870774-2 2018 VDR is the nuclear receptor for the biologically most active vitamin D metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3). Vitamin D 61-70 vitamin D receptor Homo sapiens 0-3 28870774-8 2018 In total, VDR sites with GABPA co-localization may control some 450 vitamin D target genes. Vitamin D 68-77 vitamin D receptor Homo sapiens 10-13 28951226-3 2018 Active vitamin D downregulates macrophage JNK activation, suppressing oxidized LDL cholesterol uptake and foam cell formation and promoting an anti-inflammatory phenotype. Vitamin D 7-16 mitogen-activated protein kinase 8 Mus musculus 42-45 28951226-9 2018 We have previously shown that peritoneal macrophages obtained from LDLR-/- mice fed vitamin D-deficient HFD diets have higher foam cell formation compared to those from mice on vitamin D-sufficient HFD. Vitamin D 84-93 low density lipoprotein receptor Mus musculus 67-71 29146302-1 2018 Active forms of vitamin D enhance osteoclastogenesis in vitro and in vivo through the vitamin D receptor (VDR) in osteoblast-lineage cells consisting of osteoblasts and osteocytes. Vitamin D 16-25 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 86-104 29146302-1 2018 Active forms of vitamin D enhance osteoclastogenesis in vitro and in vivo through the vitamin D receptor (VDR) in osteoblast-lineage cells consisting of osteoblasts and osteocytes. Vitamin D 16-25 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 106-109 29146302-8 2018 However, using our cKO lines, we observed that VDR in osteoblast-lineage cells, but not osteoclasts, was involved in the anti-resorptive properties of pharmacological doses of vitamin D compounds in vivo. Vitamin D 176-185 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 47-50 29561429-3 2018 Deficiency of vitamin D and decreased levels of its receptor were observed in HCV and HCV-HCC patients.The perturbation in vitamin D/VDR axis, which modulates both of autophagy and apoptosis in HCV infection, may point out to its involvement and implication in the pathogenesis of HCV infection and the development of HCV-related HCC. Vitamin D 14-23 vitamin D receptor Homo sapiens 133-136 29143122-11 2018 Monitoring oxidative stress and VDR protein content might be useful for future studies on the mechanism(s) of vitamin D action in muscle. Vitamin D 110-119 vitamin D receptor Homo sapiens 32-35 29131543-9 2018 In addition, HLA-DRB1*15:01 and HLA-DQB1*06:02 were found to be associated with lower vitamin D levels. Vitamin D 86-95 major histocompatibility complex, class II, DQ beta 1 Homo sapiens 32-40 29183090-9 2018 In conclusion, low vitamin D status was in virtually healthy subjects associated with decreased insulin sensitivity, namely in those with GG genotype of rs2228570 VDR polymorphism. Vitamin D 19-28 vitamin D receptor Homo sapiens 163-166 29371756-4 2018 In fact, plasma 1,25-dihydroxyvitamin D levels showed a significant correlation with vitamin D metabolism gene Cyp27b1 and Cyp24a1 mRNA expression in the high phosphate group. Vitamin D 30-39 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 123-130 29371756-7 2018 Our results suggest that age-related alterations in renal alpha-Klotho expression could affect the responsiveness of dietary phosphate to vitamin D metabolism. Vitamin D 138-147 klotho Mus musculus 64-70 29945780-11 2018 However, subjects with "insufficient" Vitamin D < 30 ng/mL (n = 10) had an ~2-fold greater CK increase with eccentric exercise (nominal P-value = .04) than subjects with higher vitamin D levels. Vitamin D 38-47 cytidine/uridine monophosphate kinase 1 Homo sapiens 91-93 29945780-13 2018 We did observe that low vitamin D levels are associated with a greater CK response to eccentric exercise in statin-treated subjects. Vitamin D 24-33 cytidine/uridine monophosphate kinase 1 Homo sapiens 71-73 29301185-1 2017 PURPOSE: Vitamin D deficiency is reported to be more common in type 1 diabetes patients and might be associated with the increased urinary loss of vitamin D binding protein (VDBP) consequent to impaired 25-hydroxyvitamin D (25(OH)D) circulation. Vitamin D 9-18 GC vitamin D binding protein Homo sapiens 147-172 29301185-1 2017 PURPOSE: Vitamin D deficiency is reported to be more common in type 1 diabetes patients and might be associated with the increased urinary loss of vitamin D binding protein (VDBP) consequent to impaired 25-hydroxyvitamin D (25(OH)D) circulation. Vitamin D 9-18 GC vitamin D binding protein Homo sapiens 174-178 29278636-2 2017 The genetic activity of vitamin D is determined through vitamin D receptors (VDR), a member of stero-thyreoidal family of nuclear receptors, which with vitamin D form a cell nucleus complex responsible for the chemo preventive and antitumor effect. Vitamin D 24-33 vitamin D receptor Homo sapiens 56-75 29278636-2 2017 The genetic activity of vitamin D is determined through vitamin D receptors (VDR), a member of stero-thyreoidal family of nuclear receptors, which with vitamin D form a cell nucleus complex responsible for the chemo preventive and antitumor effect. Vitamin D 24-33 vitamin D receptor Homo sapiens 77-80 29278636-2 2017 The genetic activity of vitamin D is determined through vitamin D receptors (VDR), a member of stero-thyreoidal family of nuclear receptors, which with vitamin D form a cell nucleus complex responsible for the chemo preventive and antitumor effect. Vitamin D 56-65 vitamin D receptor Homo sapiens 77-80 29176823-9 2017 This suggested complex might also include VDR, which greatly contributes to Ca+2 hemostasis with its ligand vitamin D. Vitamin D 108-117 vitamin D receptor Homo sapiens 42-45 29177013-7 2017 Serum BDNF level was significantly higher in Vit D deficient group (p = 0.001), and was decreased in the OVX + HD. Vitamin D 45-50 brain-derived neurotrophic factor Rattus norvegicus 6-10 29209434-6 2017 The studies presented in this review suggest that whether vitamin D may have beneficial effects in disease course or not, may be dependent on factors such as ethnicity, gender, diet, vitamin D receptor (VDR) polymorphisms and sunlight exposure. Vitamin D 58-67 vitamin D receptor Homo sapiens 183-201 29209434-6 2017 The studies presented in this review suggest that whether vitamin D may have beneficial effects in disease course or not, may be dependent on factors such as ethnicity, gender, diet, vitamin D receptor (VDR) polymorphisms and sunlight exposure. Vitamin D 58-67 vitamin D receptor Homo sapiens 203-206 28945992-9 2017 In conclusion, reduction of circulating miR-7 and miR-192, accompanied by elevation of miR-152, reflects a beneficial metabolic response to vitamin D treatment in people with prediabetes. Vitamin D 140-149 leukocyte immunoglobulin like receptor B1 Homo sapiens 40-45 28945992-9 2017 In conclusion, reduction of circulating miR-7 and miR-192, accompanied by elevation of miR-152, reflects a beneficial metabolic response to vitamin D treatment in people with prediabetes. Vitamin D 140-149 microRNA 152 Homo sapiens 87-94 28976989-1 2017 BACKGROUND: Vitamin D associates with the plasma concentration of the endogenous inhibitor of the nitric oxide system asymmetric dimethyl arginine (ADMA) and cross-sectional studies in CKD patients treated with the vitamin D receptor activator paricalcitol show that plasma ADMA is substantially less than in those not receiving this drug. Vitamin D 12-21 vitamin D receptor Homo sapiens 215-233 28728941-3 2017 We hypothesized that mineral homeostasis is differentially affected by R568 and 1,25D with respect to the PTH-vitamin D-FGF23-Klotho axis and bone health. Vitamin D 110-119 fibroblast growth factor 23 Mus musculus 120-125 28728941-3 2017 We hypothesized that mineral homeostasis is differentially affected by R568 and 1,25D with respect to the PTH-vitamin D-FGF23-Klotho axis and bone health. Vitamin D 110-119 klotho Mus musculus 126-132 28600880-1 2017 Fibroblast growth factor-23 (FGF23) is a bone-derived hormone regulating vitamin D hormone production and renal handling of minerals by signaling through an FGF receptor/alphaKlotho (Klotho) receptor complex. Vitamin D 73-82 fibroblast growth factor 23 Mus musculus 0-27 28600880-1 2017 Fibroblast growth factor-23 (FGF23) is a bone-derived hormone regulating vitamin D hormone production and renal handling of minerals by signaling through an FGF receptor/alphaKlotho (Klotho) receptor complex. Vitamin D 73-82 fibroblast growth factor 23 Mus musculus 29-34 28093352-1 2017 CYP24A1, encoding the vitamin D-24-hydroxylase, is of major clinical and physiologic importance, serving to regulate the catabolism of 1,25-(OH)2D, the physiologically active vitamin D metabolite. Vitamin D 22-31 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 0-7 28093352-6 2017 Disruption of CYP24A1 in mice results in elevated circulating 1,25-(OH)2D, substantiating the importance of the enzyme in the maintenance of vitamin D metabolism. Vitamin D 141-150 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 14-21 28104492-4 2017 Transient transfection of Caco-2 cells with a constitutively active mutant K-RAS (G12 V) significantly reduced 1,25(OH)2D-induced activity of both a human 25-hydroxyvitamin D, 24 hydroxyase (CYP24A1) promoter-luciferase and an artificial 3X vitamin D response element (VDRE) promoter-luciferase reporter gene. Vitamin D 165-174 KRAS proto-oncogene, GTPase Homo sapiens 75-80 28130182-8 2017 Treatment of BEC with 10muM cholecalciferol led to increases in both CYP24A1 and CFTR mRNA levels, even when added to the apical surface of cells grown in an air-liquid interface, suggesting that topical administration of vitamin D could be used therapeutically. Vitamin D 222-231 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 69-76 28130182-8 2017 Treatment of BEC with 10muM cholecalciferol led to increases in both CYP24A1 and CFTR mRNA levels, even when added to the apical surface of cells grown in an air-liquid interface, suggesting that topical administration of vitamin D could be used therapeutically. Vitamin D 222-231 cystic fibrosis transmembrane conductance regulator Mus musculus 81-85 28330721-1 2017 Vitamin D is hydroxylated in the liver and kidneys to its active form, which can bind to the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 93-111 28330721-1 2017 Vitamin D is hydroxylated in the liver and kidneys to its active form, which can bind to the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 113-116 28552837-7 2017 In the mild CTS patients, vitamin D levels were significantly lower than those electrophysiologically normal patients (P=0.003). Vitamin D 26-35 transthyretin Homo sapiens 12-15 28552837-9 2017 There was no significant relationship between the pain and vitamin D levels in the normal group, while vitamin D level was significantly lower in the mild CTS group (P=0.730 and P=0.002; respectively). Vitamin D 103-112 transthyretin Homo sapiens 155-158 28552837-10 2017 DISCUSSION: Vitamin D deficiency increases the pain intensity in patients with CTS. Vitamin D 12-21 transthyretin Homo sapiens 79-82 28552837-12 2017 Further studies involving analyses of post-vitamin D replacement therapy are warranted to confirm the association between vitamin D deficiency and pain due to CTS. Vitamin D 122-131 transthyretin Homo sapiens 159-162 29096595-1 2017 Fibroblast growth factor-23 (FGF23) is a bone-derived hormone, mainly produced by osteoblasts and osteocytes in response to increased extracellular phosphate and circulating vitamin D hormone. Vitamin D 174-183 fibroblast growth factor 23 Homo sapiens 0-27 29096595-1 2017 Fibroblast growth factor-23 (FGF23) is a bone-derived hormone, mainly produced by osteoblasts and osteocytes in response to increased extracellular phosphate and circulating vitamin D hormone. Vitamin D 174-183 fibroblast growth factor 23 Homo sapiens 29-34 29022486-7 2017 However, further studies focusing on the vitamin D receptor variants and haplotypes effects on vitamin D and vitamin D receptor concentrations, activities, and functionalities are needed. Vitamin D 41-50 vitamin D receptor Homo sapiens 109-127 29034815-3 2017 Furthermore, there has been observed a relationship between serum vitamin D and testosterone concentrations in an elderly Caucasian population carrying the vitamin D receptor FokI gene polymorphism. Vitamin D 66-75 vitamin D receptor Homo sapiens 156-174 28843271-11 2017 Vitamin D stimulated the proliferation of the vaginal epithelium by activating p-RhoA and Erzin through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 108-126 28843271-11 2017 Vitamin D stimulated the proliferation of the vaginal epithelium by activating p-RhoA and Erzin through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 128-131 28843271-12 2017 The results suggest that vitamin D positively regulates cell-to-cell junction by increasing the VDR/p-RhoA/p-Ezrin pathway. Vitamin D 25-34 vitamin D receptor Homo sapiens 96-99 29870623-1 2017 Background and purpose: This study aimed to assess the correlation between vitamin D deficiency and electrophysiological findings and pain level in patients with symptoms of carpal tunnel syndrome (CTS). Vitamin D 75-84 transthyretin Homo sapiens 198-201 29870623-5 2017 Results: Although the rate of CTS in the patients with a low vitamin D level was found to be high, no statistically significant correlation was observed between low vitamin D level and the frequency and severity of CTS. Vitamin D 61-70 transthyretin Homo sapiens 30-33 29870623-6 2017 Additionally, the pain and functional loss ratio induced by CTS was found to be higher in the group with a lower vitamin D level than in the group with normal levels. Vitamin D 113-122 transthyretin Homo sapiens 60-63 29870623-7 2017 Conclusion: Low vitamin D levels may increase the severity of CTS symptoms. Vitamin D 16-25 transthyretin Homo sapiens 62-65 29870623-8 2017 Treatment of vitamin D deficiency in patients with CTS can play a role in reducing pain and disability. Vitamin D 13-22 transthyretin Homo sapiens 51-54 28922414-2 2017 Vitamin D affects genes regulating proliferation, apoptosis, and differentiation and induces the tumor suppressor 15-hydroxyprostaglandin dehydrogenase (PGDH) in other cancers. Vitamin D 0-9 carbonyl reductase 1 Homo sapiens 114-151 28257826-2 2017 Its synthesis and its metabolites, their transport and elimination as well as action on transcriptional regulation involves the harmonic cooperation of diverse proteins with vitamin D binding capacities such as vitamin D binding protein (DBP), cytochrome P450 enzymes or the nuclear vitamin receptor (VDR). Vitamin D 174-183 GC vitamin D binding protein Homo sapiens 211-236 28257826-2 2017 Its synthesis and its metabolites, their transport and elimination as well as action on transcriptional regulation involves the harmonic cooperation of diverse proteins with vitamin D binding capacities such as vitamin D binding protein (DBP), cytochrome P450 enzymes or the nuclear vitamin receptor (VDR). Vitamin D 174-183 vitamin D receptor Homo sapiens 301-304 28257826-6 2017 Additionally, we will describe, the implications of the VDR mutants associated with hereditary vitamin D-resistant rickets (HVDRR) that display impaired function. Vitamin D 95-104 vitamin D receptor Homo sapiens 56-59 28315703-1 2017 The molecular endocrinology of vitamin D is based on the facts that i) its metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) is the high affinity ligand of the nuclear receptor vitamin D receptor (VDR) and ii) the transcription factor VDR is the unique target of 1,25(OH)2D3 in the nucleus. Vitamin D 31-40 vitamin D receptor Homo sapiens 202-205 28315703-1 2017 The molecular endocrinology of vitamin D is based on the facts that i) its metabolite 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) is the high affinity ligand of the nuclear receptor vitamin D receptor (VDR) and ii) the transcription factor VDR is the unique target of 1,25(OH)2D3 in the nucleus. Vitamin D 31-40 vitamin D receptor Homo sapiens 240-243 28315703-3 2017 Vitamin D has via VDR a direct effect on the expression of several hundred primary target genes implying numerous effects on the epigenome. Vitamin D 0-9 vitamin D receptor Homo sapiens 18-21 28342856-2 2017 The effects of vitamin D are mediated by the vitamin D receptor, which is expressed together with the vitamin D metabolizing enzymes in the reproductive tissues. Vitamin D 15-24 vitamin D receptor Homo sapiens 45-63 28526240-4 2017 Recent findings convincingly support the concept of a new function of the VDR as a tumor suppressor in skin, with key components of the vitamin D endocrine system, including VDR, CYP24A1, CYP27A1, and CYP27B1 being strongly expressed in non-melanoma skin cancer (NMSC). Vitamin D 136-145 vitamin D receptor Homo sapiens 74-77 28470390-0 2017 Biallelic mutations in CYP24A1 or SLC34A1 as a cause of infantile idiopathic hypercalcemia (IIH) with vitamin D hypersensitivity: molecular study of 11 historical IIH cases. Vitamin D 102-111 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 23-30 28955691-2 2017 Vitamin D has relevance to muscle and immune function, hypertension, diabetes mellitus, cancer, and pregnancy because vitamin D receptors (VDR) are present in many non-skeletal tissues. Vitamin D 0-9 vitamin D receptor Homo sapiens 118-137 28955691-2 2017 Vitamin D has relevance to muscle and immune function, hypertension, diabetes mellitus, cancer, and pregnancy because vitamin D receptors (VDR) are present in many non-skeletal tissues. Vitamin D 0-9 vitamin D receptor Homo sapiens 139-142 28955691-3 2017 Vitamin D acts on target tissues via the binding of its active form to VDR. Vitamin D 0-9 vitamin D receptor Homo sapiens 71-74 28575224-12 2017 Conclusions: Genetic variation in DHCR7, which encodes 7-dehyrocholesterol reductase in the epidermal vitamin D biosynthesis pathway, appears to modify baseline 25(OH)D. In contrast, the response to antenatal cholecalciferol supplementation was associated with SNPs in CYP2R1, which may alter 25-hydroxylase activity, and GC, which may affect vitamin D binding protein synthesis or metabolite affinity. Vitamin D 102-111 7-dehydrocholesterol reductase Homo sapiens 34-39 28575224-12 2017 Conclusions: Genetic variation in DHCR7, which encodes 7-dehyrocholesterol reductase in the epidermal vitamin D biosynthesis pathway, appears to modify baseline 25(OH)D. In contrast, the response to antenatal cholecalciferol supplementation was associated with SNPs in CYP2R1, which may alter 25-hydroxylase activity, and GC, which may affect vitamin D binding protein synthesis or metabolite affinity. Vitamin D 102-111 GC vitamin D binding protein Homo sapiens 343-368 28445792-13 2017 In conclusion, vitamin D deficiency in old rats increases adiposity and leads to reduced muscle protein synthesis through activation of eIF2alpha. Vitamin D 15-24 eukaryotic translation initiation factor 2A Rattus norvegicus 136-145 28256004-1 2017 BACKGROUND AND OBJECTIVE: Vitamin D-binding protein (DBP) is a highly expressed plasma protein with many important functions, including transport of vitamin D metabolites, sequestration of actin, control of bone metabolism and modulation of immune and inflammatory responses. Vitamin D 149-158 GC vitamin D binding protein Homo sapiens 26-51 27927883-1 2017 Objectives The aim of this study was to assess the vitamin D status in treatment-naive SLE patients and its association with clinical and laboratory markers of disease activity, including serum levels of IL-17 and IL-23. Vitamin D 51-60 interleukin 17A Homo sapiens 204-209 28433569-2 2017 Vitamin D Binding Protein (VDBP) is the main transporter of vitamin D in the bloodstream and genetic polymorphisms of this protein have been shown to account for a significant variability of vitamin D levels and its systemic effects. Vitamin D 60-69 GC vitamin D binding protein Homo sapiens 0-25 28433569-2 2017 Vitamin D Binding Protein (VDBP) is the main transporter of vitamin D in the bloodstream and genetic polymorphisms of this protein have been shown to account for a significant variability of vitamin D levels and its systemic effects. Vitamin D 60-69 GC vitamin D binding protein Homo sapiens 27-31 28433569-2 2017 Vitamin D Binding Protein (VDBP) is the main transporter of vitamin D in the bloodstream and genetic polymorphisms of this protein have been shown to account for a significant variability of vitamin D levels and its systemic effects. Vitamin D 191-200 GC vitamin D binding protein Homo sapiens 0-25 28433569-2 2017 Vitamin D Binding Protein (VDBP) is the main transporter of vitamin D in the bloodstream and genetic polymorphisms of this protein have been shown to account for a significant variability of vitamin D levels and its systemic effects. Vitamin D 191-200 GC vitamin D binding protein Homo sapiens 27-31 27622885-1 2017 Fibroblast growth factor-23 (FGF23) is a bone-derived hormone protecting against the potentially deleterious effects of hyperphosphatemia by suppression of phosphate reabsorption and of active vitamin D hormone synthesis in the kidney. Vitamin D 193-202 fibroblast growth factor 23 Homo sapiens 0-27 27622885-1 2017 Fibroblast growth factor-23 (FGF23) is a bone-derived hormone protecting against the potentially deleterious effects of hyperphosphatemia by suppression of phosphate reabsorption and of active vitamin D hormone synthesis in the kidney. Vitamin D 193-202 fibroblast growth factor 23 Homo sapiens 29-34 28786260-0 2017 Vitamin D and Autoimmune Diseases: Is Vitamin D Receptor (VDR) Polymorphism the Culprit? Vitamin D 0-9 vitamin D receptor Homo sapiens 38-56 28786260-0 2017 Vitamin D and Autoimmune Diseases: Is Vitamin D Receptor (VDR) Polymorphism the Culprit? Vitamin D 0-9 vitamin D receptor Homo sapiens 58-61 28899076-0 2017 Letter to the Editor: The Effect of Genetic Factors on the Response to Vitamin D Supplementation May Be Mediated by Vitamin D-Binding Protein Concentrations. Vitamin D 71-80 GC vitamin D binding protein Homo sapiens 116-141 28242261-2 2017 These physiological actions caused by vitamin D are triggered by the specific interaction between vitamin D receptor (VDR) and vitamin D. Vitamin D 38-47 vitamin D receptor Homo sapiens 98-116 28242261-2 2017 These physiological actions caused by vitamin D are triggered by the specific interaction between vitamin D receptor (VDR) and vitamin D. Vitamin D 38-47 vitamin D receptor Homo sapiens 118-121 28242261-2 2017 These physiological actions caused by vitamin D are triggered by the specific interaction between vitamin D receptor (VDR) and vitamin D. Vitamin D 98-107 vitamin D receptor Homo sapiens 118-121 28242261-3 2017 In the present study, we investigated the interactions between VDR and vitamin D derivatives using ab initio molecular simulation, in order to elucidate the reason for the significant difference in their effects on VDR activity. Vitamin D 71-80 vitamin D receptor Homo sapiens 63-66 28242261-3 2017 In the present study, we investigated the interactions between VDR and vitamin D derivatives using ab initio molecular simulation, in order to elucidate the reason for the significant difference in their effects on VDR activity. Vitamin D 71-80 vitamin D receptor Homo sapiens 215-218 28242261-5 2017 This finding will be helpful for proposing new vitamin D derivatives as a potent modulator or inhibitor against VDR. Vitamin D 47-56 vitamin D receptor Homo sapiens 112-115 28367941-1 2017 Vitamin D-dependent rickets type 2A (VDDR2A) is a rare inherited disorder with decreased tissue responsiveness to 1,25-dihydroxyvitamin D [1,25(OH)2D], caused by loss of function mutations in the vitamin D receptor (VDR) gene. Vitamin D 0-9 vitamin D receptor Homo sapiens 196-214 28367941-1 2017 Vitamin D-dependent rickets type 2A (VDDR2A) is a rare inherited disorder with decreased tissue responsiveness to 1,25-dihydroxyvitamin D [1,25(OH)2D], caused by loss of function mutations in the vitamin D receptor (VDR) gene. Vitamin D 0-9 vitamin D receptor Homo sapiens 216-219 28388568-2 2017 Moreover, plasma vitamin D was also found significantly associated with the concentration of vitamin D binding protein (VDBP). Vitamin D 17-26 GC vitamin D binding protein Homo sapiens 93-118 28388568-2 2017 Moreover, plasma vitamin D was also found significantly associated with the concentration of vitamin D binding protein (VDBP). Vitamin D 17-26 GC vitamin D binding protein Homo sapiens 120-124 28695056-5 2017 mTOR mRNA levels were higher (P=0.036) and LC3 mRNA levels were lower (P<0.001) in severe vitamin D deficiency group compared to vitamin D insufficiency group. Vitamin D 93-102 microtubule associated protein 1 light chain 3 alpha Homo sapiens 43-46 28695056-6 2017 The counts of CD4+ T cells and the CD4/CD8 ratio were significantly higher in severe vitamin D deficiency group compared to vitamin D insufficiency group (P=0.001, P<0.001,respectively). Vitamin D 85-94 CD8a molecule Homo sapiens 39-42 28617856-16 2017 CONCLUSION: VDR BsmI polymorphism was significantly associated with vitamin D deficiency and insulin resistance, but not with obesity in this population. Vitamin D 68-77 vitamin D receptor Homo sapiens 12-15 28721141-2 2017 This paper aims to define the relationship between concentration of the hydroxylated form of vitamin D (25(OH)D), the fraction of free and bioavailable vitamin D, and of vitamin D binding protein (VDBP) levels on the one hand and the prevalence of metabolic syndrome components on the other. Vitamin D 93-102 GC vitamin D binding protein Homo sapiens 170-195 28721141-2 2017 This paper aims to define the relationship between concentration of the hydroxylated form of vitamin D (25(OH)D), the fraction of free and bioavailable vitamin D, and of vitamin D binding protein (VDBP) levels on the one hand and the prevalence of metabolic syndrome components on the other. Vitamin D 93-102 GC vitamin D binding protein Homo sapiens 197-201 28177670-4 2017 The present study was designed to investigate the effect of pretreatment with vitamin D on the isoprenaline-induced infarct-like lesion in rats and the role of PPAR-gamma as a novel mechanism in vitamin-D-mediated cardioprotective effect. Vitamin D 195-204 peroxisome proliferator-activated receptor gamma Rattus norvegicus 160-170 28177670-11 2017 The prior treatment with bisphenol A diglycidyl ether (BADGE), a PPAR-gamma antagonist, significantly attenuated the protective effect of vitamin D. Vitamin D 138-147 peroxisome proliferator-activated receptor gamma Rattus norvegicus 65-75 28177670-12 2017 In conclusion, vitamin D can be demonstrated as a promising cardioprotective agent in MI and PPAR-gamma significantly contributes toward vitamin-D-mediated protection. Vitamin D 137-146 peroxisome proliferator-activated receptor gamma Rattus norvegicus 93-103 28335003-3 2017 We investigated whether variation in binding of a transcription factor, the vitamin D receptor (VDR), whose activating ligand vitamin D has been proposed as a modifiable factor in multiple disorders, could explain any of these associations. Vitamin D 76-85 vitamin D receptor Homo sapiens 96-99 28335003-11 2017 Replicated VDR-BVs associated with these disorders could represent causal disease risk alleles whose effect may be modifiable by vitamin D levels. Vitamin D 129-138 vitamin D receptor Homo sapiens 11-14 28524342-8 2017 On the contrary, serum DHEAS was significantly affected by vitamin D (MD -32.24 mug/dL, 95% CI -32.24 to -14.01) an effect which was mainly affected by the vitamin D vs placebo comparison. Vitamin D 59-68 sulfotransferase family 2A member 1 Homo sapiens 23-28 28524342-8 2017 On the contrary, serum DHEAS was significantly affected by vitamin D (MD -32.24 mug/dL, 95% CI -32.24 to -14.01) an effect which was mainly affected by the vitamin D vs placebo comparison. Vitamin D 156-165 sulfotransferase family 2A member 1 Homo sapiens 23-28 27987058-7 2017 Importantly, we also assessed the anti-inflammatory property of vitamin D in the MPTP mouse, in which it upregulated the anti-inflammatory cytokines (IL-10, IL-4 and TGF-beta) mRNA expression as well as increasing the expression of CD163, CD206 and CD204, typical hallmarks of alternative activation of microglia for anti-inflammatory signalling (M2). Vitamin D 64-73 mannose receptor, C type 1 Mus musculus 239-244 28218743-2 2017 Vitamin D is activated through hydroxylation by 25-hydroxylases (CYP2R1 or CYP27A1) and 1alpha-hydroxylase (CYP27B1) to produce 1,25(OH)2D3, or through the action of CYP11A1 to produce mono-di- and trihydroxy-D3 products that can be further modified by CYP27B1, CYP27A1, and CYP24A1. Vitamin D 0-9 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 275-282 28243735-2 2017 Mechanistic insights have given an explanation on how vitamin D exerts antineoplastic functions, which are mainly conducted via the canonical vitamin D receptor (VDR)-vitamin D response elements (VDRE) pathway. Vitamin D 54-63 vitamin D receptor Homo sapiens 142-160 28243735-2 2017 Mechanistic insights have given an explanation on how vitamin D exerts antineoplastic functions, which are mainly conducted via the canonical vitamin D receptor (VDR)-vitamin D response elements (VDRE) pathway. Vitamin D 54-63 vitamin D receptor Homo sapiens 162-165 28243735-2 2017 Mechanistic insights have given an explanation on how vitamin D exerts antineoplastic functions, which are mainly conducted via the canonical vitamin D receptor (VDR)-vitamin D response elements (VDRE) pathway. Vitamin D 142-151 vitamin D receptor Homo sapiens 162-165 28177523-2 2017 The vitamin D endocrine system regulates transcriptional programs involved in inflammation, cell growth and differentiation through the binding of vitamin D receptor (VDR) to specific VDR elements. Vitamin D 4-13 vitamin D receptor Homo sapiens 147-165 28177523-2 2017 The vitamin D endocrine system regulates transcriptional programs involved in inflammation, cell growth and differentiation through the binding of vitamin D receptor (VDR) to specific VDR elements. Vitamin D 4-13 vitamin D receptor Homo sapiens 167-170 28177523-2 2017 The vitamin D endocrine system regulates transcriptional programs involved in inflammation, cell growth and differentiation through the binding of vitamin D receptor (VDR) to specific VDR elements. Vitamin D 4-13 vitamin D receptor Homo sapiens 184-187 31084485-3 2017 The aim of this study is to explore the associations between vitamin D (FOKI) receptor gene polymorphism (VDR) and vitamin D deficiency (VDD) and chronic musculoskeletal pain. Vitamin D 61-70 vitamin D receptor Homo sapiens 106-109 27567005-10 2017 The active vitamin D hormone, 1,25(OH)2 D3 likely increased calcification in aortic smooth muscle cells perhaps by directly modulating expression of Alpl, Rankl, and Opg. Vitamin D 11-20 alkaline phosphatase, liver/bone/kidney Mus musculus 149-153 27567005-10 2017 The active vitamin D hormone, 1,25(OH)2 D3 likely increased calcification in aortic smooth muscle cells perhaps by directly modulating expression of Alpl, Rankl, and Opg. Vitamin D 11-20 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 166-169 27584938-3 2017 We review the data that vitamin D, a pleiotropic hormone, is essential for Lgr5 stem cell functions by signaling through the vitamin D receptor. Vitamin D 24-33 vitamin D receptor Homo sapiens 125-143 28324001-0 2017 CYP3A4 Induction by Rifampin: An Alternative Pathway for Vitamin D Inactivation in Patients With CYP24A1 Mutations. Vitamin D 57-66 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 97-104 28324001-1 2017 Context: The P450 enzyme CYP24A1 is the principal inactivator of vitamin D metabolites. Vitamin D 65-74 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 25-32 28186657-0 2017 Association of Vitamin D Metabolites with Parathyroid Hormone, Fibroblast Growth Factor-23, Calcium, and Phosphorus in Dogs with Various Stages of Chronic Kidney Disease. Vitamin D 15-24 parathyroid hormone Canis lupus familiaris 42-61 27978548-2 2017 Objective: To investigate whether common variants in 7 vitamin D and calcium pathway genes (VDR, GC, DHCR7, CYP2R1, CYP27B1, CYP24A1, and CASR) modify the effects of vitamin D3 or calcium supplementation on colorectal adenoma recurrence. Vitamin D 55-64 vitamin D receptor Homo sapiens 92-95 28109821-1 2017 OBJECTIVE: Hypersensitivity to vitamin D (HVD) due to a loss of function mutation of the CYP24A1 gene, which encodes vitamin D catabolizing enzyme was initially described as a cause of acute hypercalcemia in children and chronic renal diseases in adults. Vitamin D 31-40 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 89-96 28109821-1 2017 OBJECTIVE: Hypersensitivity to vitamin D (HVD) due to a loss of function mutation of the CYP24A1 gene, which encodes vitamin D catabolizing enzyme was initially described as a cause of acute hypercalcemia in children and chronic renal diseases in adults. Vitamin D 117-126 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 89-96 28456639-6 2017 The loss of peripheral catabolism of vitamin D metabolites in patients with an inactivating mutation of CYP24A1 is responsible for persistent high levels of 1,25-dihydroxyvitamin D especially after sun exposure and a charge of native vitamin D. Vitamin D 37-46 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 104-111 28456639-6 2017 The loss of peripheral catabolism of vitamin D metabolites in patients with an inactivating mutation of CYP24A1 is responsible for persistent high levels of 1,25-dihydroxyvitamin D especially after sun exposure and a charge of native vitamin D. Vitamin D 171-180 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 104-111 28362172-5 2017 Common variants on vitamin D metabolism-related genes CYP24A1, DHCR7, GC, CYP27B1, and vitamin D receptor (VDR) and the plasma 25(OH)D level were determined. Vitamin D 19-28 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 54-61 28290237-15 2017 Lower vitamin D status has been found in HT patients than in controls, and inverse relationships of serum vitamin D with TPO/Tg antibodies have been reported. Vitamin D 106-115 thyroid peroxidase Homo sapiens 121-124 28290237-16 2017 However, other data and the lack of trial evidence suggest that low vitamin D status is more likely the result of autoimmune disease processes that include vitamin D receptor dysfunction. Vitamin D 68-77 vitamin D receptor Homo sapiens 156-174 28206978-3 2017 Vitamin D not only maintains calcium and bone homeostasis, but also mostly inhibits tumor genesis, invasion, and metastasis through activation of vitamin D receptor. Vitamin D 0-9 vitamin D receptor Homo sapiens 146-164 28425954-6 2017 We find a majority of association studies confirming a predisposing role for vitamin D receptor (VDR) polymorphisms and those of the vitamin D metabolism, particularly the CYP27B1 gene encoding the main enzyme for vitamin D activation. Vitamin D 77-86 vitamin D receptor Homo sapiens 97-100 28460457-2 2017 Vitamin D inhibits breast cancer growth through activation of the vitamin D receptor (VDR) and via classical nuclear signaling pathways. Vitamin D 0-9 vitamin D receptor Homo sapiens 66-84 28460457-2 2017 Vitamin D inhibits breast cancer growth through activation of the vitamin D receptor (VDR) and via classical nuclear signaling pathways. Vitamin D 0-9 vitamin D receptor Homo sapiens 86-89 28460457-10 2017 This new mechanism of VDR action in breast cancer cells contrasts the known anti-proliferative nuclear actions of the VDR-vitamin D ligand complex. Vitamin D 122-131 vitamin D receptor Homo sapiens 22-25 28460457-10 2017 This new mechanism of VDR action in breast cancer cells contrasts the known anti-proliferative nuclear actions of the VDR-vitamin D ligand complex. Vitamin D 122-131 vitamin D receptor Homo sapiens 118-121 28415985-5 2017 Patients were genotyped for functional variants on vitamin D synthetic pathway including GC (rs4588, rs7041, rs22020, rs2282679), CYP2R1 (rs2060793, rs12794714), CYP27B1 (rs10877012), and DHCR7 (rs12785878). Vitamin D 51-60 7-dehydrocholesterol reductase Homo sapiens 188-193 28242615-1 2017 CYP24A1, the primary inactivating enzyme for vitamin D, is often overexpressed in human cancers, potentially neutralizing the antitumor effects of calcitriol, the active form of vitamin D. Vitamin D 45-54 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 0-7 28242615-1 2017 CYP24A1, the primary inactivating enzyme for vitamin D, is often overexpressed in human cancers, potentially neutralizing the antitumor effects of calcitriol, the active form of vitamin D. Vitamin D 178-187 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 0-7 28284354-1 2017 Vitamin D binding protein (DBP) gene encodes for Gc, an alpha2 globulin that transports vitamin D metabolites in serum. Vitamin D 88-97 GC vitamin D binding protein Homo sapiens 0-25 28443031-1 2017 The vitamin D receptor (VDR) knockout (KO) mouse is a common model to unravel novel metabolic functions of vitamin D. Vitamin D 4-13 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 24-27 28376103-0 2017 Correction of vitamin D deficiency facilitated suppression of IP-10 and DPP IV levels in patients with chronic hepatitis C: A randomised double-blinded, placebo-control trial. Vitamin D 14-23 C-X-C motif chemokine ligand 10 Homo sapiens 62-67 28376103-5 2017 Vitamin D suppressed expression of IP-10 from monocytes in vitro. Vitamin D 0-9 C-X-C motif chemokine ligand 10 Homo sapiens 35-40 28376103-7 2017 We hypothesized that correction of vitamin D insufficiency or deficiency in CHC patients might restore immune dysregulation through a pathway linked to the TH1/Th2 cytokines, IP-10 or DPP IV. Vitamin D 35-44 negative elongation factor complex member C/D Homo sapiens 156-159 28376103-7 2017 We hypothesized that correction of vitamin D insufficiency or deficiency in CHC patients might restore immune dysregulation through a pathway linked to the TH1/Th2 cytokines, IP-10 or DPP IV. Vitamin D 35-44 C-X-C motif chemokine ligand 10 Homo sapiens 175-180 28376103-13 2017 Our important finding revealed that upon correction of vitamin D insufficiency or deficiency, the serum IP-10 and DPP IV levels were decreased significantly as compare to the placebo group (delta changes; 83.27 vs -133.80; 95% CI [-326.910, -40.758], p = 0.0125, and 271.04 vs -518.69; 95% CI [-1179,15, -59.781], p = 0.0305, respectively. Vitamin D 55-64 C-X-C motif chemokine ligand 10 Homo sapiens 104-109 28116494-0 2017 Use of surface plasmon resonance in the binding study of vitamin D, metabolites and analogues with vitamin D binding protein. Vitamin D 57-66 GC vitamin D binding protein Homo sapiens 99-124 27714313-5 2017 There are several shared effects of vitamin D and UVR on T cells including inhibition of proliferation and suppression of IFN-gamma and IL-17 producing T cells. Vitamin D 36-45 interleukin 17A Homo sapiens 136-141 28296915-6 2017 Thirteen SNPs derived from vitamin D cascade-related genes, including DHCR7 (rs12785878), CYP27B1 (rs10877012), CYP2R1 (rs2060793, rs12794714), GC (rs4588, rs7041, rs222020, rs2282679), and VDR (FokI, BsmI, Tru9I, ApaI, TaqI), were genotyped. Vitamin D 27-36 7-dehydrocholesterol reductase Homo sapiens 70-75 28296915-6 2017 Thirteen SNPs derived from vitamin D cascade-related genes, including DHCR7 (rs12785878), CYP27B1 (rs10877012), CYP2R1 (rs2060793, rs12794714), GC (rs4588, rs7041, rs222020, rs2282679), and VDR (FokI, BsmI, Tru9I, ApaI, TaqI), were genotyped. Vitamin D 27-36 vitamin D receptor Homo sapiens 190-193 28196884-0 2017 Functional genomics analysis of vitamin D effects on CD4+ T cells in vivo in experimental autoimmune encephalomyelitis . Vitamin D 32-41 Cd4 molecule Rattus norvegicus 53-56 28196884-4 2017 Using transcriptome, methylome, and pathway analyses in CD4+ T cells, we show that vitamin D affects multiple signaling and metabolic pathways critical for T-cell activation and differentiation into Th1 and Th17 subsets in vivo. Vitamin D 83-92 Cd4 molecule Rattus norvegicus 56-59 28196884-5 2017 Namely, Jak/Stat, Erk/Mapk, and Pi3K/Akt/mTor signaling pathway genes were down-regulated upon vitamin D supplementation. Vitamin D 95-104 mechanistic target of rapamycin kinase Rattus norvegicus 41-45 27535551-4 2017 Furthermore, raising serum calcium levels in Cyp27b1-depleted mice directly increased FGF23 levels and indirectly enhanced the action of ambient vitamin D metabolites via the vitamin D receptor. Vitamin D 145-154 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 175-193 28163705-3 2016 In the context of autoimmune diseases, this is illustrated by correlations of vitamin D status and genetic polymorphisms in the vitamin D receptor with the incidence and severity of the disease. Vitamin D 78-87 vitamin D receptor Homo sapiens 128-146 27955890-10 2017 Serum IP-10 and vitamin D levels were found to be significantly related to viral-asthma attacks (IP-10; aOR: 8.93, p=0.03 and vitamin D; aOR: 0.82, p=0.001). Vitamin D 16-25 C-X-C motif chemokine ligand 10 Homo sapiens 97-102 27955890-10 2017 Serum IP-10 and vitamin D levels were found to be significantly related to viral-asthma attacks (IP-10; aOR: 8.93, p=0.03 and vitamin D; aOR: 0.82, p=0.001). Vitamin D 126-135 C-X-C motif chemokine ligand 10 Homo sapiens 6-11 28123720-2 2017 Vitamin D receptor has been shown to be expressed in several types of immune cells suggesting vitamin D may have immune regulatory roles. Vitamin D 94-103 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 0-18 28123720-13 2017 However, in vitamin D-treated mice, the thymus indexes, the ratios of CD4+/CD8+, secretion of IL-2 and the proliferation index of spleen T lymphocytes were significantly increased (P<0.05). Vitamin D 12-21 CD4 antigen Mus musculus 70-73 27407090-2 2017 Vitamin D receptor (VDR) is central for vitamin D-mediated transcription regulation. Vitamin D 40-49 vitamin D receptor Homo sapiens 0-18 27407090-2 2017 Vitamin D receptor (VDR) is central for vitamin D-mediated transcription regulation. Vitamin D 40-49 vitamin D receptor Homo sapiens 20-23 27407090-10 2017 The present findings of VDR expression are consistent with our previous results of circulating vitamin D biomarkers, which provide two converging lines of evidence supporting the putative benefits of vitamin D against aggressive breast cancer. Vitamin D 200-209 vitamin D receptor Homo sapiens 24-27 29074824-2 2017 Vitamin D endocrine system is required for bone and mineral homeostasis through the active form of vitamin D[1alpha,25(OH)2D3]transported to the target organs, where the vitamin D receptor(VDR)is present. Vitamin D 0-9 vitamin D receptor Homo sapiens 170-188 29074824-2 2017 Vitamin D endocrine system is required for bone and mineral homeostasis through the active form of vitamin D[1alpha,25(OH)2D3]transported to the target organs, where the vitamin D receptor(VDR)is present. Vitamin D 0-9 vitamin D receptor Homo sapiens 189-192 29074824-2 2017 Vitamin D endocrine system is required for bone and mineral homeostasis through the active form of vitamin D[1alpha,25(OH)2D3]transported to the target organs, where the vitamin D receptor(VDR)is present. Vitamin D 99-108 vitamin D receptor Homo sapiens 170-188 29074824-2 2017 Vitamin D endocrine system is required for bone and mineral homeostasis through the active form of vitamin D[1alpha,25(OH)2D3]transported to the target organs, where the vitamin D receptor(VDR)is present. Vitamin D 99-108 vitamin D receptor Homo sapiens 189-192 29074824-3 2017 The biological significance of 1alpha,25(OH)2D3-VDR signalling is regarded not only in classical target of vitamin D involved in calcium and phosphate homeostasis, such as intestine, bone, kidney and parathyroid glands, but also in many other non-classical target cells of vitamin D including skin keratinocytes, pancreatic beta cells, cardiomyocytes, T-lymphocytes, bone marrow macrophages, among others. Vitamin D 107-116 vitamin D receptor Homo sapiens 48-51 29074824-3 2017 The biological significance of 1alpha,25(OH)2D3-VDR signalling is regarded not only in classical target of vitamin D involved in calcium and phosphate homeostasis, such as intestine, bone, kidney and parathyroid glands, but also in many other non-classical target cells of vitamin D including skin keratinocytes, pancreatic beta cells, cardiomyocytes, T-lymphocytes, bone marrow macrophages, among others. Vitamin D 273-282 vitamin D receptor Homo sapiens 48-51 29074824-4 2017 Although 1alpha,25(OH)2D3-VDR signalling in classical target organs of vitamin D has been extensively studied, its precise function in these target organs still needs further investigation. Vitamin D 71-80 vitamin D receptor Homo sapiens 26-29 29074825-6 2017 The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3[1,25(OH)2D3], acts as a physiological VDR ligand, and regulates various physiological processes, including calcium and bone metabolism, cellular growth and differentiation, immunity, and cardiovascular function. Vitamin D 19-28 vitamin D receptor Homo sapiens 98-101 27915991-2 2017 The vitamin D receptor (VDR), a member of the nuclear receptor superfamily, is a receptor for the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], and mediates vitamin D regulation of specific target gene expression. Vitamin D 113-122 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 4-22 27915991-2 2017 The vitamin D receptor (VDR), a member of the nuclear receptor superfamily, is a receptor for the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3], and mediates vitamin D regulation of specific target gene expression. Vitamin D 113-122 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 24-27 27915991-5 2017 In addition to epidemiological studies on vitamin D status, genome-wide analyses and cellular and animal experiments have shown that VDR is involved in the prevention of inflammatory bowel disease (IBD) and colorectal cancer (CRC). Vitamin D 42-51 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 133-136 27915991-6 2017 VDR deletion in mice exaggerates colitis and colon tumorigenesis in experimental models, and treatment of mice with synthetic vitamin D analogues ameliorates pathological changes in these diseases. Vitamin D 126-135 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 0-3 27652999-2 2016 RECENT FINDINGS: FGF-23 is a hormone produced by osteocytes and osteoblasts that aids with phosphate excretion by the kidney and acts as a negative feedback regulator for activated vitamin D synthesis. Vitamin D 181-190 fibroblast growth factor 23 Homo sapiens 17-23 27813049-1 2016 The aim of this study was to map the genetic expression of the vitamin D metabolizing enzymes CYP27A, CYP27B1, CYP2R1, and CYP24A1 in the first trimester in different human fetal tissues. Vitamin D 63-72 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 123-130 27902451-3 2016 Furthermore, in recent years it has been discovered that the vitamin D receptor (VDR) is widely distributed in many organs and tissues where vitamin D can perform other actions that include the modulation of the immune response, insulin secretion, anti-proliferative effect on cells of vascular smooth muscle, modulation of the renin-angiotensin-aldosterone system and regulates cell growth in several organs. Vitamin D 61-70 vitamin D receptor Homo sapiens 81-84 27420410-0 2016 Evaluation of the correlation between serum levels of vitamin D and vitamin D receptor gene polymorphisms in an Egyptian population. Vitamin D 54-63 vitamin D receptor Homo sapiens 68-86 27721113-10 2016 Our results suggest that the vitamin D-related genes RXRG and GC affect LDL-c levels. Vitamin D 29-38 retinoid X receptor gamma Homo sapiens 53-57 26729468-1 2016 AIM: Abnormal upregulation of CYP24 contributes to vitamin D insufficiency and resistance to vitamin D therapy in chronic kidney disease (CKD), because human CYP24 is a key enzyme involved in the inactivation of 1a,25-dihydroxyvitamin D3 (1a,25(OH)2D3; calcitriol) and 1,25(OH)2D3. Vitamin D 51-60 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 30-35 26729468-1 2016 AIM: Abnormal upregulation of CYP24 contributes to vitamin D insufficiency and resistance to vitamin D therapy in chronic kidney disease (CKD), because human CYP24 is a key enzyme involved in the inactivation of 1a,25-dihydroxyvitamin D3 (1a,25(OH)2D3; calcitriol) and 1,25(OH)2D3. Vitamin D 51-60 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 158-163 26729468-1 2016 AIM: Abnormal upregulation of CYP24 contributes to vitamin D insufficiency and resistance to vitamin D therapy in chronic kidney disease (CKD), because human CYP24 is a key enzyme involved in the inactivation of 1a,25-dihydroxyvitamin D3 (1a,25(OH)2D3; calcitriol) and 1,25(OH)2D3. Vitamin D 93-102 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 30-35 26729468-1 2016 AIM: Abnormal upregulation of CYP24 contributes to vitamin D insufficiency and resistance to vitamin D therapy in chronic kidney disease (CKD), because human CYP24 is a key enzyme involved in the inactivation of 1a,25-dihydroxyvitamin D3 (1a,25(OH)2D3; calcitriol) and 1,25(OH)2D3. Vitamin D 93-102 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 158-163 27273785-10 2016 CONCLUSIONS: Vitamin D deficiency was associated with pulmonary function deficits among obese children, but not among normal-weight children with asthma, an association that was independent of Th1 and Th2 serum inflammatory measures. Vitamin D 13-22 negative elongation factor complex member C/D Homo sapiens 193-196 27555076-0 2016 Vitamin D Treatment Effect on Serum Endocan and High-Sensitivity C-Reactive Protein Levels in Renal Transplant Patients. Vitamin D 0-9 endothelial cell specific molecule 1 Homo sapiens 36-43 27555076-3 2016 OBJECTIVE: Our aim was to investigate the relationship between vitamin D treatment and serum endocan and high-sensitivity C-reactive protein (hs-CRP) levels as inflammatory markers in transplant patients. Vitamin D 63-72 endothelial cell specific molecule 1 Homo sapiens 93-100 27555076-12 2016 A moderate negative correlation was determined between endocan and 25-OH-vitamin D levels after treatment with vitamin D ( r = -.36, P = .02). Vitamin D 73-82 endothelial cell specific molecule 1 Homo sapiens 55-62 27895321-4 2016 The purpose of this study was to assess the relation between levels of vitamin D receptor (VDR) gene expression and serum vitamin D with NP. Vitamin D 71-80 vitamin D receptor Homo sapiens 91-94 26906498-8 2016 A correlation analysis demonstrated that endocan levels were positively correlated with body mass index (BMI), thyroid-stimulating hormone (TSH), anti-thyroid peroxidase, and anti-thyroglobulin and negatively correlated with free thyroid hormone 4 (FT4) and vitamin D levels. Vitamin D 258-267 endothelial cell specific molecule 1 Homo sapiens 41-48 27454349-6 2016 Expert opinion: There is an increasing appreciation of the impact of vitamin D and its receptor VDR not only in bone biology, but also for metabolic diseases, immunological disorders, and cancer. Vitamin D 69-78 vitamin D receptor Homo sapiens 96-99 27318428-8 2016 In infants with vitamin D level below the median the prevalence of CD4+ CXCR3+ (Th1) and CD8+ CXCR3+ cell subsets was higher, while the prevalence of CD4+ CCR4+ (Th2), CD8+ CCR4+ and plasmacytoid dendritic cell (pDC) subsets was lower than in those with vitamin D level above median. Vitamin D 16-25 negative elongation factor complex member C/D Homo sapiens 80-83 27318428-8 2016 In infants with vitamin D level below the median the prevalence of CD4+ CXCR3+ (Th1) and CD8+ CXCR3+ cell subsets was higher, while the prevalence of CD4+ CCR4+ (Th2), CD8+ CCR4+ and plasmacytoid dendritic cell (pDC) subsets was lower than in those with vitamin D level above median. Vitamin D 16-25 CD8a molecule Homo sapiens 89-92 27318428-8 2016 In infants with vitamin D level below the median the prevalence of CD4+ CXCR3+ (Th1) and CD8+ CXCR3+ cell subsets was higher, while the prevalence of CD4+ CCR4+ (Th2), CD8+ CCR4+ and plasmacytoid dendritic cell (pDC) subsets was lower than in those with vitamin D level above median. Vitamin D 16-25 CD8a molecule Homo sapiens 168-171 27318428-11 2016 CONCLUSIONS: Vitamin D levels may together with cortisol levels and gestational age have an effect on Th1/Th2 balance and the prevalence of plasmocytoid dendritic cells in the preterm newborn. Vitamin D 13-22 negative elongation factor complex member C/D Homo sapiens 102-105 27341425-0 2016 Association between vitamin D and depressive symptoms varies by season: Results from the German Health Interview and Examination Survey for Adults (DEGS1). Vitamin D 20-29 delta 4-desaturase, sphingolipid 1 Homo sapiens 148-153 27898971-8 2016 From d 0 to 35 in the nursery, pigs from sows fed increasing vitamin D had increased (quadratic, < 0.003) ADG and ADFI, but G:F was similar regardless of maternal vitamin D regimen. Vitamin D 61-70 ADG Sus scrofa 109-112 26282157-9 2016 These data suggest that vitamin D and calcium signaling are necessary components of the epidermal response to wounding, likely by regulating stem cell activation through increased beta-catenin transcriptional activity. Vitamin D 24-33 catenin (cadherin associated protein), beta 1 Mus musculus 180-192 26361014-12 2016 VDR mRNA levels in tibiae from vitamin D deficient mice were 0.7 fold lower than those in control mice. Vitamin D 31-40 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 0-3 26429395-2 2016 Since adipocytes express VDR and obesity is a known risk factor for cancer, vitamin D actions in adipose tissue may contribute to its cancer protective effects. Vitamin D 76-85 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 25-28 26523676-2 2016 The biologically active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3), serves as a ligand of the nuclear receptor vitamin D receptor (VDR). Vitamin D 32-41 vitamin D receptor Homo sapiens 151-154 26523676-6 2016 Primary and secondary vitamin D target genes being up- and down-regulated were related to changes in the epigenome of THP-1 cells, such as 1,25(OH)2D3-dependent chromatin opening and modulation of the genome-wide association of the transcription factors VDR and CCCTC-binding factor (CTCF) with their respective genomic binding sites. Vitamin D 22-31 vitamin D receptor Homo sapiens 254-257 26686945-6 2016 There was limited overlap between genetic determinants of vitamin D status and those associated with non-skeletal health outcomes: polymorphisms in DBP, CYP2R1 and DHCR7 were the most frequent to be reported to associate with circulating concentrations of 25(OH)D, while polymorphisms in VDR were most commonly reported to associate with non-skeletal health outcomes, among which infectious and autoimmune diseases were the most represented. Vitamin D 58-67 7-dehydrocholesterol reductase Homo sapiens 164-169 26690785-2 2016 Global Vdr deletion in a mouse model (Vdr-/-) results in hypocalcemia, secondary hyperparathyroidism and bone features typical of vitamin D-dependent rickets type II. Vitamin D 130-139 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 7-10 26690785-2 2016 Global Vdr deletion in a mouse model (Vdr-/-) results in hypocalcemia, secondary hyperparathyroidism and bone features typical of vitamin D-dependent rickets type II. Vitamin D 130-139 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 38-41 27554639-7 2016 A reduction in TAZ can also enhance the sensitivity of tumor cells to vitamin D by regulating the p53/CYP24A1 pathway. Vitamin D 70-79 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 102-109 27784318-10 2016 Different from normal FGF23 and PTH, serum 25-hydroxyvitamin D was significantly lower in Ank KI/KI mice and vitamin D insufficiency was found in four out of seven CMD patients. Vitamin D 53-62 progressive ankylosis Mus musculus 90-93 27803671-3 2016 The active vitamin D metabolite, 1,25-dihydroxyvitamin D3 (1,25D3), bound to its receptor, the vitamin D receptor (VDR) regulates the expression of hundreds of different genes in a cell- and tissue-specific manner. Vitamin D 11-20 vitamin D receptor Homo sapiens 95-113 27803671-3 2016 The active vitamin D metabolite, 1,25-dihydroxyvitamin D3 (1,25D3), bound to its receptor, the vitamin D receptor (VDR) regulates the expression of hundreds of different genes in a cell- and tissue-specific manner. Vitamin D 11-20 vitamin D receptor Homo sapiens 115-118 27477355-1 2016 Vitamin D was found to be involved in liver fibrosis modulation through binding to its receptor (VDR) halting many fibrotic pathways. Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 97-100 27477355-2 2016 Targeting vitamin D-VDR axis using vitamin D analogs may represent an efficient strategy for liver fibrosis treatment . Vitamin D 10-19 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 20-23 27725127-0 2016 Vitamin D modulates different IL-17-secreting T cell subsets in multiple sclerosis patients. Vitamin D 0-9 interleukin 17A Homo sapiens 30-35 27736940-2 2016 Polymorphisms in the gene encoding vitamin D receptor (VDR), which mediates most of the known cellular effects of vitamin D, have been suggested to alter this association. Vitamin D 35-44 vitamin D receptor Homo sapiens 55-58 27785371-9 2016 Osteoclast fusion transcripts transmembrane 7 subfamily member 4 (tm7sf4) and nuclear factor of activated T-cell cytoplasmic 1 (nfatc1) where downregulated in response to vitamin D metabolites. Vitamin D 171-180 nuclear factor of activated T cells 1 Homo sapiens 78-126 27785371-9 2016 Osteoclast fusion transcripts transmembrane 7 subfamily member 4 (tm7sf4) and nuclear factor of activated T-cell cytoplasmic 1 (nfatc1) where downregulated in response to vitamin D metabolites. Vitamin D 171-180 nuclear factor of activated T cells 1 Homo sapiens 128-134 27716304-6 2016 The vitamin D load increased the average plasma 25(OH)D concentration to 116 +- 34 nmol/L (mean +- SD); the median concentration was 122 nmol/L (interquartile range 103-134); VDBP concentrations did not change. Vitamin D 4-13 GC vitamin D binding protein Homo sapiens 175-179 27716192-0 2016 Sequence analysis of four vitamin D family genes (VDR, CYP24A1, CYP27B1 and CYP2R1) in Vogt-Koyanagi-Harada (VKH) patients: identification of a potentially pathogenic variant in CYP2R1. Vitamin D 26-35 vitamin D receptor Homo sapiens 50-53 27716192-0 2016 Sequence analysis of four vitamin D family genes (VDR, CYP24A1, CYP27B1 and CYP2R1) in Vogt-Koyanagi-Harada (VKH) patients: identification of a potentially pathogenic variant in CYP2R1. Vitamin D 26-35 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 55-62 27211082-10 2016 CONCLUSION: Calcium plus vitamin D supplementation during pregnancy interacted with polymorphisms in the VDR gene promoter region affecting postpartum bone loss. Vitamin D 25-34 vitamin D receptor Homo sapiens 105-108 27697512-0 2016 DHCR7: A vital enzyme switch between cholesterol and vitamin D production. Vitamin D 53-62 7-dehydrocholesterol reductase Homo sapiens 0-5 27697512-3 2016 Besides serving as a substrate for DHCR7, 7-dehydrocholesterol is also a precursor of vitamin D via the action of ultraviolet light on the skin. Vitamin D 86-95 7-dehydrocholesterol reductase Homo sapiens 35-40 27697512-4 2016 Thus, DHCR7 exerts complex biological effects, involved in both cholesterol and vitamin D production. Vitamin D 80-89 7-dehydrocholesterol reductase Homo sapiens 6-11 27697512-5 2016 Indeed, we argue that DHCR7 can act as a switch between cholesterol and vitamin D synthesis. Vitamin D 72-81 7-dehydrocholesterol reductase Homo sapiens 22-27 27697512-6 2016 This review summarizes current knowledge about the critical enzyme DHCR7, highlighting recent findings regarding its structure, transcriptional and post-transcriptional regulation, and its links to vitamin D synthesis. Vitamin D 198-207 7-dehydrocholesterol reductase Homo sapiens 67-72 27829825-0 2016 Matrix Metalloproteinase (MMP)-9 Levels in Children on Hemodialysis: Association with MMP-9 C-1562T Gene Polymorphism and Vitamin D Levels. Vitamin D 122-131 matrix metallopeptidase 9 Homo sapiens 0-32 26567049-1 2016 AIM: Chronic kidney disease (CKD) is associated with an inflammation-mediated process, and the vitamin D (3) catabolizing enzyme, CYP24, is frequently overexpressed in CKD, where it may play a crucial role in kidney disease. Vitamin D 95-104 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 130-135 27570856-11 2016 CONCLUSION: The presence of GG allele of the SNP rs2228570 of VDR gene, SNPs rs4588 of GC gene and CYP2R1 rs10741657 gene was associated with vitamin D deficiency. Vitamin D 142-151 vitamin D receptor Homo sapiens 62-65 27571093-7 2016 Interestingly, a significant correlation between 25(OH) vitamin D and TPO-Ab (r = -0.27, p = 0.03) and FT3 (r = 0.35, p = 0.006) has been found in subjects with AT while no correlation was found between 25(OH) vitamin D levels and TG-Ab (r = -0.15, p = 0.25), TSH (r = -0.014, p = 0.09) and FT4 (r = 0.13, p = 0.32). Vitamin D 56-65 thyroid peroxidase Homo sapiens 70-73 27530414-5 2016 In this study, we investigated the presence of vitamin D machinery and metabolism in ADMSCs by analyzing the expression levels of vitamin D receptor (VDR), vitamin D metabolizing enzymes (CYP24A1 and CYP27B1) after in vitro stimulation with active vitamin D, calcitriol. Vitamin D 47-56 vitamin D receptor Homo sapiens 130-148 27530414-5 2016 In this study, we investigated the presence of vitamin D machinery and metabolism in ADMSCs by analyzing the expression levels of vitamin D receptor (VDR), vitamin D metabolizing enzymes (CYP24A1 and CYP27B1) after in vitro stimulation with active vitamin D, calcitriol. Vitamin D 47-56 vitamin D receptor Homo sapiens 150-153 27649525-2 2016 The enzyme that produces the active metabolite of vitamin D and ligand for VDR, namely CYP27B1, likewise is widely expressed in many cells of the body. Vitamin D 50-59 vitamin D receptor Homo sapiens 75-78 27154546-2 2016 Vitamin D-dependent rickets type II (VDDRII) is a congenital disease caused by inactivating mutations in the VDR The condition is treated with high doses of calcitriol, but the therapeutic effects of other synthetic VD3 analogs have not yet been investigated. Vitamin D 0-9 vitamin D receptor Homo sapiens 109-112 27512288-1 2016 [Purpose] The effects of vitamin D on the circulating levels of IL-17 and IL-13 were investigated in patients with diabetic peripheral neuropathy, patients with diabetes mellitus type 2 without neuropathy, and healthy controls. Vitamin D 25-34 interleukin 17A Homo sapiens 64-69 27512288-10 2016 [Conclusion] Vitamin D is a potential modifiable risk factor for diabetic peripheral neuropathy and may regulate inflammatory mediators, e.g., IL-17 and IL-13. Vitamin D 13-22 interleukin 17A Homo sapiens 143-148 27239732-15 2016 The anti-inflammatory potential of VDR activation in vitamin D insufficient patients is highly selective and appears to be mediated by an effect on calcineurin-mediated responses. Vitamin D 53-62 vitamin D receptor Homo sapiens 35-38 27399065-9 2016 Levels of cytochrome P450 (CYP) 27A1 were significantly decreased, whereas levels of CYP24A1 were significantly elevated in cirrhotic patients.These results suggest that decreasing vitamin D levels are likely to be a result, rather than a cause, of liver dysfunction and irrespective of HBV viral load. Vitamin D 181-190 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 85-92 26466946-0 2016 The multiple sclerosis-associated regulatory variant rs10877013 affects expression of CYP27B1 and VDR under inflammatory or vitamin D stimuli. Vitamin D 124-133 vitamin D receptor Homo sapiens 98-101 26466946-5 2016 Finally, CYP24A1 was highly induced by the active form of vitamin D and its expression correlated with the expression of VDR in LCLs but neither the MS-associated variant in the region (rs2248359) nor any other variant located in 1 Mb around CYP24A1 was associated with its expression. Vitamin D 58-67 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 9-16 26466946-5 2016 Finally, CYP24A1 was highly induced by the active form of vitamin D and its expression correlated with the expression of VDR in LCLs but neither the MS-associated variant in the region (rs2248359) nor any other variant located in 1 Mb around CYP24A1 was associated with its expression. Vitamin D 58-67 vitamin D receptor Homo sapiens 121-124 26928188-1 2016 UNLABELLED: There is growing need for a reliable assay for measuring fibroblast growth factor 23 (FGF23), a regulator of phosphorus and vitamin D. Vitamin D 136-145 fibroblast growth factor 23 Homo sapiens 69-96 26928188-1 2016 UNLABELLED: There is growing need for a reliable assay for measuring fibroblast growth factor 23 (FGF23), a regulator of phosphorus and vitamin D. Vitamin D 136-145 fibroblast growth factor 23 Homo sapiens 98-103 26939683-0 2016 Fibroblast growth factor-23 and renin-angiotensin system levels in vitamin-D-dependent rickets type I. Vitamin D 67-76 fibroblast growth factor 23 Homo sapiens 0-37 27362433-7 2016 We confirmed that vitamin D increased mRNA and protein expression of endogenous nephrin in cultivated glomeruli. Vitamin D 18-27 nephrosis 1, nephrin Mus musculus 80-87 27408766-0 2016 Clinical and genetic findings in a Chinese family with VDR-associated hereditary vitamin D-resistant rickets. Vitamin D 81-90 vitamin D receptor Homo sapiens 55-58 27309378-1 2016 BACKGROUND: Vitamin D, causally implicated in bone diseases and human malignancies, exerts its effects through binding to the vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 126-144 27309378-1 2016 BACKGROUND: Vitamin D, causally implicated in bone diseases and human malignancies, exerts its effects through binding to the vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 146-149 27203211-1 2016 The relationship between age, vitamin D status, expression and functionality of the vitamin D receptor (VDR), and key genes in the vitamin D pathway in immune cells is unclear. Vitamin D 84-93 vitamin D receptor Homo sapiens 104-107 28394106-3 2016 Almost all tissues possess vitamin D receptor (VDR).The mice lacking VDR (VDR knockout mice) have greatly contributed to the understanding of the general vitamin D physiologic function. Vitamin D 27-36 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 47-50 28394106-3 2016 Almost all tissues possess vitamin D receptor (VDR).The mice lacking VDR (VDR knockout mice) have greatly contributed to the understanding of the general vitamin D physiologic function. Vitamin D 27-36 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 69-72 28394106-3 2016 Almost all tissues possess vitamin D receptor (VDR).The mice lacking VDR (VDR knockout mice) have greatly contributed to the understanding of the general vitamin D physiologic function. Vitamin D 27-36 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 69-72 26864938-2 2016 Initially discovered as a regulator of phosphate and vitamin D homeostasis, FGF23 has now been implicated in several pathophysiological mechanisms that may negatively impact the cardiovascular and renal systems. Vitamin D 53-62 fibroblast growth factor 23 Homo sapiens 76-81 27272846-0 2016 Thyroid Hormones and Vitamin D in Patients with Breast Cancer with Mutations in BRCA1 or BRCA2 Genes. Vitamin D 21-30 BRCA1 DNA repair associated Homo sapiens 80-85 27272846-0 2016 Thyroid Hormones and Vitamin D in Patients with Breast Cancer with Mutations in BRCA1 or BRCA2 Genes. Vitamin D 21-30 BRCA2 DNA repair associated Homo sapiens 89-94 27272846-3 2016 The purpose of this investigation was to evaluate the association of thyroid gland function and vitamin D with BC in patients with BRCA mutations. Vitamin D 96-105 BRCA1 DNA repair associated Homo sapiens 131-135 27272846-8 2016 A significantly increased level of vitamin D in BRCA2-mutation carriers compared to those without mutation (p=0.02) was detected. Vitamin D 35-44 BRCA2 DNA repair associated Homo sapiens 48-53 27272846-12 2016 Vitamin D was significantly elevated in BRCA2-mutation carriers and the observation of a better tumor grade in this group could be consistent with the ability of vitamin D to inhibit growth and induce differentiation. Vitamin D 0-9 BRCA2 DNA repair associated Homo sapiens 40-45 27272846-12 2016 Vitamin D was significantly elevated in BRCA2-mutation carriers and the observation of a better tumor grade in this group could be consistent with the ability of vitamin D to inhibit growth and induce differentiation. Vitamin D 162-171 BRCA2 DNA repair associated Homo sapiens 40-45 27230841-4 2016 FGF23 is a hormone secreted from osteocytes and osteoblasts and acts on renal tubular cells to promote phosphate excretion into the urine and suppress synthesis of active form of vitamin D (1,25-dihydroxyvitamin D3;1,25(OH)(2)D(3)). Vitamin D 179-188 fibroblast growth factor 23 Mus musculus 0-5 27184015-9 2016 Low serum vitamin D levels are associated with a higher prevalence of TPO antibodies, but intervention studies with extra vitamin D have not been done yet. Vitamin D 10-19 thyroid peroxidase Homo sapiens 70-73 27065588-0 2016 Vitamin D Receptor (VDR) Gene Polymorphisms (FokI, BsmI) and their Relation to Vitamin D Status in Pediatrics betaeta Thalassemia Major. Vitamin D 0-9 vitamin D receptor Homo sapiens 20-23 27065588-3 2016 Expression and activation of the vitamin D receptor (VDR) are necessary for the effects of vitamin D, in which several single nucleotide polymorphisms have been identified especially (FokI, BsmI). Vitamin D 33-42 vitamin D receptor Homo sapiens 53-56 27065588-9 2016 In conclusion, these results suggest that the VDR (FokI, BsmI) gene polymorphisms influence vitamin D status, (Ff,ff), BB genotypes had lower vitamin D levels, so they might influence risk of development of bone diseases in beta thalassemia major. Vitamin D 92-101 vitamin D receptor Homo sapiens 46-49 27065588-9 2016 In conclusion, these results suggest that the VDR (FokI, BsmI) gene polymorphisms influence vitamin D status, (Ff,ff), BB genotypes had lower vitamin D levels, so they might influence risk of development of bone diseases in beta thalassemia major. Vitamin D 142-151 vitamin D receptor Homo sapiens 46-49 26704532-4 2016 The 25-hydroxylation involves mainly CYP2R1 and CYP27A1, whereas 1alpha-hydroxylation and 24-hydroxylation are catalyzed by CYP27B1 and CYP24A1, respectively, and are tightly regulated to maintain adequate levels of the active vitamin D hormone, 1alpha,25(OH)2D3. Vitamin D 227-236 cytochrome P450, family 24, subfamily a, polypeptide 1 Mus musculus 136-143 26704532-8 2016 We found that these cells express mRNAs for the four major CYP450 enzymes involved in vitamin D activation and inactivation, and vitamin D receptor (VDR) that mediates vitamin D actions. Vitamin D 129-138 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 149-152 27483726-1 2016 Vitamin D (VitD), a lipid-soluble hormone, is able to regulate the transcription of many genes through vitamin D receptor (vitD receptor-VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 103-121 27483726-1 2016 Vitamin D (VitD), a lipid-soluble hormone, is able to regulate the transcription of many genes through vitamin D receptor (vitD receptor-VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 137-140 27064335-5 2016 It is assumed that vitamin D deficiency and genetic predisposition, for example, polymorphisms of vitamin D receptor, have a great significance. Vitamin D 19-28 vitamin D receptor Homo sapiens 98-116 27114922-1 2016 INTRODUCTION: We studied the frequencies of the 3" and 5"-end vitamin D receptor (VDR) gene polymorphisms and their correlation with bone mineral density (BMD) in Egyptian pediatric acute lymphoblastic leukemia (ALL) patients receiving calcium and vitamin D supplements. Vitamin D 62-71 vitamin D receptor Homo sapiens 82-85 27114922-2 2016 The purpose of this study is to find out the relation between VDR polymorphism and the response to vitamin D intake in pediatric ALL cases who receive corticosteroid therapy which predispose to osteoporosis. Vitamin D 99-108 vitamin D receptor Homo sapiens 62-65 27186331-3 2016 Vitamin-D action is mediated by the vitamin-D receptor. Vitamin D 0-9 vitamin D receptor Homo sapiens 36-54 26943962-0 2016 Immunomodulation by vitamin D in multiple sclerosis: More than IL-17. Vitamin D 20-29 interleukin 17A Homo sapiens 63-68 26423691-9 2016 In addition, the finding that the VDR polymorphism TaqI was associated with myopathy may indicate a causal relationship between vitamin D function and myopathy, but larger studies are needed before firm conclusions can be drawn. Vitamin D 128-137 vitamin D receptor Homo sapiens 34-37 27134818-2 2016 Recent advances in understanding the systemic control of Fibroblast growth factor-23 (FGF23) has uncovered novel effectors of endocrine feedback loops for calcium, phosphate, and vitamin D balance that interact with "traditional" feedback loops for mineral metabolism. Vitamin D 179-188 fibroblast growth factor 23 Homo sapiens 57-84 27134818-2 2016 Recent advances in understanding the systemic control of Fibroblast growth factor-23 (FGF23) has uncovered novel effectors of endocrine feedback loops for calcium, phosphate, and vitamin D balance that interact with "traditional" feedback loops for mineral metabolism. Vitamin D 179-188 fibroblast growth factor 23 Homo sapiens 86-91 26930567-0 2016 Vitamin D improves endothelial dysfunction and restores myeloid angiogenic cell function via reduced CXCL-10 expression in systemic lupus erythematosus. Vitamin D 0-9 C-X-C motif chemokine ligand 10 Homo sapiens 101-108 26911666-8 2016 CONCLUSION: Vitamin D related (VDR rs2228570 and CYP2R1 rs10741657) and IL28B rs12979860 genes polymorphisms accurately assure SVR in naive CHC G4 patients treated with low cost standard therapy. Vitamin D 12-21 vitamin D receptor Homo sapiens 31-34 26910045-3 2016 The results demonstrate that Vitamin D significantly inhibited the abilities of T lymphocytes to produce IFN-gamma and proliferate in vitro (P<=0.05), but retained their ability to undergo degranulation, which is a maker for cytotoxicity of these cells. Vitamin D 29-38 interferon gamma Gallus gallus 105-114 26901218-8 2016 Thus, genes controlling the turnover of vitamin D (CYP27B1, CYP24A1), vitamin A (ALDH1A3, AKR1B10), and cholesterol (CYP7B1), were up-regulated in psoriasis, whereas melanomas showed downregulation of genes regulating turnover of vitamin A (AKR1C3), and cholesterol (CYP39A1). Vitamin D 40-49 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 60-67 26315479-0 2016 A Promoter Polymorphism of the Vitamin D Metabolism Gene Cyp24a1 is Associated with Severe Atopic Dermatitis in Adults. Vitamin D 31-40 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 57-64 25727561-1 2016 Vitamin D is a steroid hormone, which in active form binds to the vitamin D receptor. Vitamin D 0-9 vitamin D receptor Homo sapiens 66-84 26047794-2 2016 Recently, mutations in the vitamin D catabolizing enzyme 25-hydroxyvitamin D3-24-hydroxylase (CYP24A1) were described that lead to increased sensitivity to vitamin D due to accumulation of the active metabolite 1,25-(OH)2D3. Vitamin D 27-36 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 94-101 26047794-2 2016 Recently, mutations in the vitamin D catabolizing enzyme 25-hydroxyvitamin D3-24-hydroxylase (CYP24A1) were described that lead to increased sensitivity to vitamin D due to accumulation of the active metabolite 1,25-(OH)2D3. Vitamin D 67-76 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 94-101 26287968-1 2016 Although fibroblast growth factor (FGF) 23 was recently identified as a phosphatonin that influences vitamin D metabolism, the underlying signaling mechanisms remain unclear. Vitamin D 101-110 fibroblast growth factor 23 Homo sapiens 35-38 26446365-1 2016 Vitamin D has been considered as an immune modulator, and exerted the effect through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 89-107 26446365-1 2016 Vitamin D has been considered as an immune modulator, and exerted the effect through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 109-112 26893716-0 2016 Polymorphic variants in the vitamin D pathway genes and the risk of ovarian cancer among non-carriers of BRCA1/BRCA2 mutations. Vitamin D 28-37 BRCA1 DNA repair associated Homo sapiens 105-110 26893716-0 2016 Polymorphic variants in the vitamin D pathway genes and the risk of ovarian cancer among non-carriers of BRCA1/BRCA2 mutations. Vitamin D 28-37 BRCA2 DNA repair associated Homo sapiens 111-116 26678915-5 2016 Both vitamin D receptor (VDR) and 25-hydroxyvitamin D3 1-alpha-hydroxylase (CYP27B1) are expressed in several types of immune cells (i.e. antigen presenting cells, T and B cells), and thus, they are able to synthetize the bioactive form of vitamin D that modulates both the innate and adaptive immune system. Vitamin D 5-14 vitamin D receptor Homo sapiens 25-28 26220765-3 2016 Furthermore, recent data suggest that bioavailable vitamin D, which also integrates the levels of vitamin D binding proteins and albumin, could be a biologically more relevant parameter than 25(OH)D. METHODS: Measured de-seasonalized 25(OH)D3 and vitamin D binding protein and calculated bioavailable and free vitamin D were compared in the baseline serum samples of 76 patients with clinically isolated syndrome enrolled in a longitudinal observational study and in 76 age- and sex-matched healthy controls (HC). Vitamin D 51-60 GC vitamin D binding protein Homo sapiens 98-123 26853300-2 2016 Immune cells express the vitamin D receptor, including antigen presenting cells, T cells and B cells, and these cells are all capable of synthesizing the biologically active vitamin D metabolite, 1, 25 hydroxy vitamin D.There has been growing interest in the benefits of supplementing vitamin D as studies report vitamin D insufficiency (circulating 25(OH)D < 50 nmol/L) in more than half of all athletes and military personnel tested during the winter, when skin sunlight UVB is negligible. Vitamin D 174-183 vitamin D receptor Homo sapiens 25-43 26853300-2 2016 Immune cells express the vitamin D receptor, including antigen presenting cells, T cells and B cells, and these cells are all capable of synthesizing the biologically active vitamin D metabolite, 1, 25 hydroxy vitamin D.There has been growing interest in the benefits of supplementing vitamin D as studies report vitamin D insufficiency (circulating 25(OH)D < 50 nmol/L) in more than half of all athletes and military personnel tested during the winter, when skin sunlight UVB is negligible. Vitamin D 174-183 vitamin D receptor Homo sapiens 25-43 27355663-1 2016 BACKGROUND: Fibroblast growth factor-23 (FGF23) is a bone-derived hormone that regulates the homeostasis of phosphate and vitamin D. Vitamin D 122-131 fibroblast growth factor 23 Homo sapiens 12-39 27355663-1 2016 BACKGROUND: Fibroblast growth factor-23 (FGF23) is a bone-derived hormone that regulates the homeostasis of phosphate and vitamin D. Vitamin D 122-131 fibroblast growth factor 23 Homo sapiens 41-46 26235988-1 2016 Fibroblast growth factor-23 (Fgf23) is a bone-derived hormone, suppressing phosphate reabsorption and vitamin D hormone (1,25(OH)2 D3 ) production in the kidney. Vitamin D 102-111 fibroblast growth factor 23 Mus musculus 0-27 26235988-1 2016 Fibroblast growth factor-23 (Fgf23) is a bone-derived hormone, suppressing phosphate reabsorption and vitamin D hormone (1,25(OH)2 D3 ) production in the kidney. Vitamin D 102-111 fibroblast growth factor 23 Mus musculus 29-34 27713770-9 2016 Discussion:Altered levels of Vit D affect the balance between LL-37, IL-8 and SAA, suggesting an association with AAU, an extra-articular manifestation of AS. Vitamin D 29-34 serum amyloid A1 cluster Homo sapiens 78-81 26522682-0 2016 Vitamin D deficiency impairs glucose-stimulated insulin secretion and increases insulin resistance by reducing PPAR-gamma expression in nonobese Type 2 diabetic rats. Vitamin D 0-9 peroxisome proliferator-activated receptor gamma Rattus norvegicus 111-121 26522682-11 2016 In conclusion, vitamin D deficiency resulted in the dysregulation of glucose metabolism in GK rats by simultaneously increasing insulin resistance by decreasing adipose PPAR-gamma expression and deteriorating beta-cell function and mass. Vitamin D 15-24 peroxisome proliferator-activated receptor gamma Rattus norvegicus 169-179 25777538-6 2016 The effect of dietary vitamin D on colonic Wnt signaling was investigated in mice fed either with 100 IU or 2500 IU vitamin D/kg diet. Vitamin D 22-31 wingless-type MMTV integration site family, member 5A Mus musculus 43-46 25777538-12 2016 In healthy colon of mice fed with high vitamin D diet, the mRNA levels of Wnt5a and ROR2, that promote degradation of beta-catenin, were upregulated whereas beta-catenin and TCF4 protein expression were decreased. Vitamin D 39-48 wingless-type MMTV integration site family, member 5A Mus musculus 74-79 25777538-12 2016 In healthy colon of mice fed with high vitamin D diet, the mRNA levels of Wnt5a and ROR2, that promote degradation of beta-catenin, were upregulated whereas beta-catenin and TCF4 protein expression were decreased. Vitamin D 39-48 catenin (cadherin associated protein), beta 1 Mus musculus 118-130 25777538-12 2016 In healthy colon of mice fed with high vitamin D diet, the mRNA levels of Wnt5a and ROR2, that promote degradation of beta-catenin, were upregulated whereas beta-catenin and TCF4 protein expression were decreased. Vitamin D 39-48 catenin (cadherin associated protein), beta 1 Mus musculus 157-169 26058412-8 2016 However, vitamin D could reverse the inhibition of both VDR and LL-37 [1.5-fold increase (P = 0.001) and 2000-fold increase (P < 0.001) respectively]. Vitamin D 9-18 vitamin D receptor Homo sapiens 56-59 26058412-10 2016 CONCLUSIONS: When vitamin D levels were low, bacteria inhibited VDR and LL-37 responses in peritoneal macrophages as a mechanism to evade antibacterial defence. Vitamin D 18-27 vitamin D receptor Homo sapiens 64-67 26058412-11 2016 Vitamin D supplementation could up-regulate peritoneal macrophage VDR and LL-37 expressions, which resulted in an enhanced immunological defence against SBP in patients with cirrhosis and ascites. Vitamin D 0-9 vitamin D receptor Homo sapiens 66-69 27298518-0 2016 Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy. Vitamin D 9-18 interleukin 10 Homo sapiens 79-84 27298518-7 2016 Maternal vitamin D level was inversely correlated with IL-10 response to TLR3 (p = 0.004) and TLR7-8 stimulation (p = 0.006). Vitamin D 9-18 interleukin 10 Homo sapiens 55-60 27298518-10 2016 In conclusion, our study had shown that maternal vitamin D, but not cord vitamin D level, was associated with viral TLR-triggered IL-10 response. Vitamin D 49-58 interleukin 10 Homo sapiens 130-135 26602143-1 2016 Patients with significant proteinuria represent a unique population with respect to vitamin D status due to the urinary losses of vitamin D-binding protein (DBP) to which >99 % of circulating 25-hydroxy vitamin D (25(OH)D) is bound. Vitamin D 84-93 GC vitamin D binding protein Homo sapiens 130-155 26686848-3 2016 Recent studies have demonstrated that vitamin D, through its receptor (VDR), is able to regulate the immune balance and suppress the autoimmunity process, being a potential target in autoimmune diseases. Vitamin D 38-47 vitamin D receptor Homo sapiens 71-74 26567701-1 2016 The endocrine fibroblast growth factors (FGFs), FGF19, FGF21 and FGF23, are critical for maintaining whole-body homeostasis, with roles in bile acid, glucose and lipid metabolism, modulation of vitamin D and phosphate homeostasis and metabolic adaptation during fasting. Vitamin D 194-203 fibroblast growth factor 23 Homo sapiens 65-70 26904920-1 2016 Vitamin D receptor (VDR) gene polymorphisms may influence risk for adenomatous polyps (AP), a benign precursor to colon cancer, via modulation of vitamin D sensitive pathways, including cell proliferation and differentiation. Vitamin D 146-155 vitamin D receptor Homo sapiens 0-18 26904920-1 2016 Vitamin D receptor (VDR) gene polymorphisms may influence risk for adenomatous polyps (AP), a benign precursor to colon cancer, via modulation of vitamin D sensitive pathways, including cell proliferation and differentiation. Vitamin D 146-155 vitamin D receptor Homo sapiens 20-23 26681795-6 2016 Although the identification of mechanisms mediating VDR-regulated transcription has been one focus of recent research in the field, other topics of fundamental importance include the identification and functional significance of proteins involved in the metabolism of vitamin D. Vitamin D 268-277 vitamin D receptor Homo sapiens 52-55 26366751-4 2016 Vitamin D receptor activation using a vitamin D responsive element-mediated cytochrome P450 3A4 reporter gene assay was investigated in Caco-2 cells transfected with human vitamin D receptor. Vitamin D 38-47 vitamin D receptor Homo sapiens 0-18 26827954-2 2016 This activity is commonly attributed to direct binding of 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3, calcitriol], the hormonally active form of vitamin D, to the vitamin D receptor (VDR). Vitamin D 77-86 vitamin D receptor Homo sapiens 168-186 26827954-2 2016 This activity is commonly attributed to direct binding of 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3, calcitriol], the hormonally active form of vitamin D, to the vitamin D receptor (VDR). Vitamin D 77-86 vitamin D receptor Homo sapiens 188-191 26827954-3 2016 More recently, calcitriol and VDR have been shown to control the expression of genes associated with cellular proliferation and differentiation in a wide variety of cells, suggesting more extensive biological activities for the vitamin D system. Vitamin D 228-237 vitamin D receptor Homo sapiens 30-33 26827958-5 2016 Biological effects of vitamin D are mediated by altered expression of a gene network regulated by the vitamin D receptor (VDR), which is a multidomain, ligand-inducible transcription factor similar to AR and other nuclear receptors. Vitamin D 22-31 vitamin D receptor Homo sapiens 102-120 26827958-5 2016 Biological effects of vitamin D are mediated by altered expression of a gene network regulated by the vitamin D receptor (VDR), which is a multidomain, ligand-inducible transcription factor similar to AR and other nuclear receptors. Vitamin D 22-31 vitamin D receptor Homo sapiens 122-125 26827958-7 2016 Androgen inhibits vitamin D-mediated induction of CYP24A1, the calcitriol-degrading enzyme, while vitamin D promotes androgen inactivation by inducing phase I monooxygenases (e.g., CYP3A4) and phase II transferases (e.g., SULT2B1b, a DHEA-sulfotransferase). Vitamin D 18-27 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 50-57 26827962-7 2016 CYP24A1 inhibitors plus 1,25D3 can cause dose-limiting toxicity of vitamin D (hypercalcemia) in some patients. Vitamin D 67-76 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 0-7 26396142-6 2015 Mechanistic studies have shown that calcitriol-active form of vitamin D-influences inflammatory processes involved in cancer progression, including the enzyme cyclooxygenase 2, the NF-kappaB pathway, and the expression of the cytokines TNFalpha, IL1beta, IL6, IL8, IL17, and TGFbeta1. Vitamin D 62-71 interleukin 17A Homo sapiens 265-269 26441239-9 2015 Introduction of transgenes for either mouse or human VDR also normalized vitamin D metabolism in VDR null mice, whereas this metabolic pattern was unaffected by a transgene encoding a ligand binding-deficient mutant (L233S) human VDR. Vitamin D 73-82 vitamin D receptor Homo sapiens 53-56 27141540-1 2015 BACKGROUND: Vitamin D and insulin play an important role in susceptibility to polycystic ovary syndrome (PCOS), and therefore vitamin D receptor (VDR), parathyroid hormone (PTH), and insulin receptor (INSR) gene variants might be involved in the pathogenesis of PCOS. Vitamin D 12-21 vitamin D receptor Homo sapiens 126-144 26677265-3 2015 Vitamin D has stimulatory effects on melanocytes and acts through its nuclear Vitamin D receptor (VDR) on target cells. Vitamin D 0-9 vitamin D receptor Homo sapiens 78-96 26677265-3 2015 Vitamin D has stimulatory effects on melanocytes and acts through its nuclear Vitamin D receptor (VDR) on target cells. Vitamin D 0-9 vitamin D receptor Homo sapiens 98-101 26332676-1 2015 Vitamin D-binding protein (DBP) is a multifunctional protein that has attracted increasing interest in recent years, largely because of its potential role in modulating the activity of vitamin D. Vitamin D 185-194 GC vitamin D binding protein Homo sapiens 0-25 26424141-10 2015 While activated vitamin D therapy is associated with improved outcomes, it also leads to higher fibroblast growth factor 23 (FGF-23) levels, which may be detrimental in dialysis patients. Vitamin D 16-25 fibroblast growth factor 23 Homo sapiens 96-123 26424141-10 2015 While activated vitamin D therapy is associated with improved outcomes, it also leads to higher fibroblast growth factor 23 (FGF-23) levels, which may be detrimental in dialysis patients. Vitamin D 16-25 fibroblast growth factor 23 Homo sapiens 125-131 27025071-0 2015 [The history of creation and study of vitamin D medicines in the Laboratory of Medical Biochemistry of Palladin Institute of Biochemistry of NAS of Ukraine for 1990-2015]. Vitamin D 38-47 palladin, cytoskeletal associated protein Homo sapiens 103-111 26517870-1 2015 BACKGROUND: Vitamin D is postulated to decrease the risk of breast cancer by inhibiting cell proliferation via the vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 115-133 26517870-1 2015 BACKGROUND: Vitamin D is postulated to decrease the risk of breast cancer by inhibiting cell proliferation via the vitamin D receptor (VDR). Vitamin D 12-21 vitamin D receptor Homo sapiens 135-138 26291576-5 2015 In innate immunity, vitamin D promotes production of cathelicidin and beta-defensin 2 and enhances the capacity for autophagy via toll-like receptor activation as well as affects complement concentrations. Vitamin D 20-29 defensin beta 4B Homo sapiens 70-85 26291576-7 2015 Vitamin D also increases T helper (Th) 2 cytokine production and the efficiency of Treg lymphocytes but suppresses the secretion of Th1 and Th17 cytokines. Vitamin D 0-9 negative elongation factor complex member C/D Homo sapiens 132-135 26355700-1 2015 Active forms of vitamin D regulate the expression of multiple genes that play essential roles in calcium and phosphate homeostasis, cell differentiation, and the immune system via the vitamin D receptor (VDR). Vitamin D 16-25 vitamin D receptor Homo sapiens 184-202 26355700-1 2015 Active forms of vitamin D regulate the expression of multiple genes that play essential roles in calcium and phosphate homeostasis, cell differentiation, and the immune system via the vitamin D receptor (VDR). Vitamin D 16-25 vitamin D receptor Homo sapiens 204-207 26355700-7 2015 Our results on chimeric luciferases containing the LBDs of mutant VDRs derived from patients with vitamin D-dependent type II rickets indicated that our system could detect a conformational change of the LBD of the VDR likely based on a positional change of the helix 12, which occurs upon ligand binding. Vitamin D 98-107 vitamin D receptor Homo sapiens 66-69 26010336-1 2015 Even in cells that are resistant to the differentiating effects of vitamin D, the activated vitamin D receptor (VDR) can downregulate the mitochondrial respiratory chain and sustain cell growth through enhancing the activity of biosynthetic pathways. Vitamin D 67-76 vitamin D receptor Homo sapiens 92-110 26010336-1 2015 Even in cells that are resistant to the differentiating effects of vitamin D, the activated vitamin D receptor (VDR) can downregulate the mitochondrial respiratory chain and sustain cell growth through enhancing the activity of biosynthetic pathways. Vitamin D 67-76 vitamin D receptor Homo sapiens 112-115 26722516-0 2015 Alterations in vitamin D signaling pathway in gastric cancer progression: a study of vitamin D receptor expression in human normal, premalignant, and malignant gastric tissue. Vitamin D 15-24 vitamin D receptor Homo sapiens 85-103 26214117-13 2015 We confirm the accuracy and effectiveness of a novel blood test estimating the ratio between relevant vitamin D metabolites as a useful screening tool for CYP24A1 mutations. Vitamin D 102-111 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 155-162 26276877-2 2015 IL-10 is considered a chief effector molecule that promotes the vitamin D-induced immunosuppressive states of T cells and accessory cells. Vitamin D 64-73 interleukin 10 Homo sapiens 0-5 26276877-3 2015 In this article, we demonstrate that the active form of vitamin D, 1,25-dihydroxyvitamin D3 (calcitriol), has a profound inhibitory effect on the development of human Th9, a CD4 T cell subset that is highly associated with asthma, in an IL-10-independent manner. Vitamin D 56-65 interleukin 10 Homo sapiens 237-242 26298324-0 2015 Vitamin D and estrogen synergy in Vdr-expressing CD4(+) T cells is essential to induce Helios(+)FoxP3(+) T cells and prevent autoimmune demyelinating disease. Vitamin D 0-9 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 34-37 26298324-0 2015 Vitamin D and estrogen synergy in Vdr-expressing CD4(+) T cells is essential to induce Helios(+)FoxP3(+) T cells and prevent autoimmune demyelinating disease. Vitamin D 0-9 CD4 antigen Mus musculus 49-52 26458343-1 2015 BACKGROUND & OBJECTIVES: The Vitamin-D receptor (VDR) regulates vitamin D levels and calcium metabolism in the body and these are known to be associated with endocrine dysfunctions, insulin resistance and type-2 diabetes in polycystic ovarian syndrome (PCOS). Vitamin D 68-77 vitamin D receptor Homo sapiens 33-51 26458343-1 2015 BACKGROUND & OBJECTIVES: The Vitamin-D receptor (VDR) regulates vitamin D levels and calcium metabolism in the body and these are known to be associated with endocrine dysfunctions, insulin resistance and type-2 diabetes in polycystic ovarian syndrome (PCOS). Vitamin D 68-77 vitamin D receptor Homo sapiens 53-56 26188623-0 2015 Vitamin D supplementation up-regulates IL-6 and IL-17A gene expression in multiple sclerosis patients. Vitamin D 0-9 interleukin 17A Homo sapiens 48-54 26188623-3 2015 The aim of this study was to investigate the vitamin D effects on the expression level of IL-6 and IL-17A in peripheral blood mononuclear cells (PBMCs) of multiple sclerosis (MS) patients. Vitamin D 45-54 interleukin 17A Homo sapiens 99-105 26188623-5 2015 Significant up-regulation of IL-6 and IL-17A gene expression was shown under vitamin D treatment. Vitamin D 77-86 interleukin 17A Homo sapiens 38-44 25740667-4 2015 The purpose of the study is to find out the Th1/Th2 status by estimating TNF-alpha (Th1 marker) and IL-4 (Th2 marker) in ovarian cancer cases and controls and to correlate these with serum vitamin D levels. Vitamin D 189-198 negative elongation factor complex member C/D Homo sapiens 44-47 25740667-11 2015 CONCLUSIONS: Low vitamin D levels promotes Th1 activity increasing TNF-alpha levels and inhibits Th2 activity decreasing IL-4 levels in ovarian cancer. Vitamin D 17-26 negative elongation factor complex member C/D Homo sapiens 43-46 25736056-8 2015 Four of these 11 genes (CYP24A1, CLMN, EFTUD1, and SERPINB1) were also identified as 1,25D responsive in human breast tumor explants, suggesting that this gene signature may prove useful as a biomarker of vitamin D exposure in breast tissue. Vitamin D 205-214 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 24-31 26037400-0 2015 Vitamin D levels in multiple sclerosis patients: Association with TGF-beta2, TGF-betaRI, and TGF-betaRII expression. Vitamin D 0-9 transforming growth factor beta 2 Homo sapiens 66-75 26037400-3 2015 Here, we aim to study whether vitamin D affects TGF-beta pathway gene expression and Expanded Disability Status Scale (EDSS) scores in MS patients. Vitamin D 30-39 transforming growth factor beta 2 Homo sapiens 48-56 26037400-8 2015 SIGNIFICANCE: Here, we demonstrate new evidence for the complex role of vitamin D in the pathogenesis, activity and progression of MS through the TGF-beta signaling pathway. Vitamin D 72-81 transforming growth factor beta 2 Homo sapiens 146-154 26025591-8 2015 The presence of vitamin D receptor (VDR) and the enzyme responsible for conversion of the 25(OH)D in its active metabolite 25(OH)2D3 in extra renal tissue shows the involvement of vitamin D in other diseases like cancer, diabetes, multiple sclerosis etc. Vitamin D 16-25 vitamin D receptor Homo sapiens 36-39 25517289-1 2015 OBJECTIVE: To examine the vitamin D status, SNP of the vitamin D receptor gene (VDR) and the effects of vitamin D supplementation on parathyroid hormone and insulin secretion in adult males with obesity or normal weight in a subtropical Chinese city. Vitamin D 55-64 vitamin D receptor Homo sapiens 80-83 26288665-4 2015 Sophisticated experimental techniques have allowed detection of the vitamin D receptor (VDR) on skeletal muscle and cerebellar tissue, which if validated in further large studies, could confirm the mechanism of vitamin D in these associations. Vitamin D 68-77 vitamin D receptor Homo sapiens 88-91 25804799-2 2015 The mechanism of vitamin D action is mediated by the vitamin D receptor (VDR). Vitamin D 17-26 vitamin D receptor Homo sapiens 53-71 25804799-2 2015 The mechanism of vitamin D action is mediated by the vitamin D receptor (VDR). Vitamin D 17-26 vitamin D receptor Homo sapiens 73-76 26041780-8 2015 We then conducted a ChIP sequence analysis of binding sites for the vitamin D receptor (VDR) across the proximal intestine in vitamin D-sufficient normal mice treated with vehicle or 1,25(OH)2D3. Vitamin D 68-77 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 88-91 26193703-1 2015 BACKGROUND: Increased fibroblast growth factor 23 (FGF23), a bone-derived hormone involved in the regulation of phosphate and vitamin D metabolism, has been related to the development of cardiovascular disease (CVD) in chronic kidney disease patients and in the general population. Vitamin D 126-135 fibroblast growth factor 23 Homo sapiens 22-49 26193703-1 2015 BACKGROUND: Increased fibroblast growth factor 23 (FGF23), a bone-derived hormone involved in the regulation of phosphate and vitamin D metabolism, has been related to the development of cardiovascular disease (CVD) in chronic kidney disease patients and in the general population. Vitamin D 126-135 fibroblast growth factor 23 Homo sapiens 51-56 26162848-0 2015 Vitamin D status among adults in Germany--results from the German Health Interview and Examination Survey for Adults (DEGS1). Vitamin D 0-9 delta 4-desaturase, sphingolipid 1 Homo sapiens 118-123 26162848-3 2015 With data from the "German Health Interview and Examination Survey for Adults" (DEGS1) the current situation of vitamin D status can be analysed. Vitamin D 112-121 delta 4-desaturase, sphingolipid 1 Homo sapiens 80-85 26019137-2 2015 Fibroblast growth factor 23 (FGF23) is an endocrine FGF, normally expressed by osteocytes, which plays a critical role in phosphate homeostasis via a feedback loop involving the kidney and vitamin D. Vitamin D 189-198 fibroblast growth factor 23 Homo sapiens 0-27 26019137-2 2015 Fibroblast growth factor 23 (FGF23) is an endocrine FGF, normally expressed by osteocytes, which plays a critical role in phosphate homeostasis via a feedback loop involving the kidney and vitamin D. Vitamin D 189-198 fibroblast growth factor 23 Homo sapiens 29-34 26217190-10 2015 The immuno-modulatory properties of vitamin D receptor (VDR) suggest that vitamin D is an attractive and plausible candidate in spite of controversial findings. Vitamin D 36-45 vitamin D receptor Homo sapiens 56-59 26180726-9 2015 The physiologically active form of vitamin D, 1,25(OH)2D3, inhibits the proliferation of keloid fibroblasts, and correlations between vitamin D receptor polymorphisms, such as the TaqI CC genotype, and keloid formation have been reported. Vitamin D 35-44 vitamin D receptor Homo sapiens 134-152 26149120-0 2015 Vitamin D Deficiency in Uygurs and Kazaks Is Associated with Polymorphisms in CYP2R1 and DHCR7/NADSYN1 Genes. Vitamin D 0-9 7-dehydrocholesterol reductase Homo sapiens 89-94 26149120-0 2015 Vitamin D Deficiency in Uygurs and Kazaks Is Associated with Polymorphisms in CYP2R1 and DHCR7/NADSYN1 Genes. Vitamin D 0-9 NAD synthetase 1 Homo sapiens 95-102 26149120-12 2015 : 361-31.357), while DHCR7/NADSYN1-rs12785878 was significantly associated with the presence of vitamin D deficiency in the Kazak ethnic population (P=0.011, OR=2.442, 95%C.I. Vitamin D 96-105 7-dehydrocholesterol reductase Homo sapiens 21-26 26149120-12 2015 : 361-31.357), while DHCR7/NADSYN1-rs12785878 was significantly associated with the presence of vitamin D deficiency in the Kazak ethnic population (P=0.011, OR=2.442, 95%C.I. Vitamin D 96-105 NAD synthetase 1 Homo sapiens 27-34 26149120-16 2015 Polymorphisms in CYP2R1-rs10766197 and DHCR7/NADSYN1-rs12785878 are associated with vitamin D deficiency in Uygur and Kazak ethnic populations. Vitamin D 84-93 7-dehydrocholesterol reductase Homo sapiens 39-44 26149120-16 2015 Polymorphisms in CYP2R1-rs10766197 and DHCR7/NADSYN1-rs12785878 are associated with vitamin D deficiency in Uygur and Kazak ethnic populations. Vitamin D 84-93 NAD synthetase 1 Homo sapiens 45-52 25904071-0 2015 The Vitamin D Analogue Calcipotriol Reduces the Frequency of CD8+ IL-17+ T Cells in Psoriasis Lesions. Vitamin D 4-13 CD8a molecule Homo sapiens 61-64 25904071-0 2015 The Vitamin D Analogue Calcipotriol Reduces the Frequency of CD8+ IL-17+ T Cells in Psoriasis Lesions. Vitamin D 4-13 interleukin 17A Homo sapiens 66-71 26105695-1 2015 Vitamin D is a potential protective agent against cancer, and its activity is mediated mainly by vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 97-115 26105695-1 2015 Vitamin D is a potential protective agent against cancer, and its activity is mediated mainly by vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 117-120 25940599-9 2015 The positive correlation of VDBP levels and placental transporter expression suggests that delivery of vitamin D to the placenta may be important. Vitamin D 103-112 GC vitamin D binding protein Homo sapiens 28-32 26107738-0 2015 Vitamin D regulates cytokine patterns secreted by dendritic cells to promote differentiation of IL-22-producing T cells. Vitamin D 0-9 interleukin 22 Homo sapiens 96-101 26107738-3 2015 Moreover, whether vitamin D treatment of DCs regulates their ability to promote differentiation of IL-17-/IL-22-producing T cell subsets, such as Th17 and Th22 cell, is not known. Vitamin D 18-27 interleukin 17A Homo sapiens 99-104 26107738-3 2015 Moreover, whether vitamin D treatment of DCs regulates their ability to promote differentiation of IL-17-/IL-22-producing T cell subsets, such as Th17 and Th22 cell, is not known. Vitamin D 18-27 interleukin 22 Homo sapiens 106-111 26107738-5 2015 Cytokines secreted by vitamin D-treated DC were significantly more potent in driving differentiation of IL-22-producing T cells, but not IL-17-producing T cells, as compared to secreted cytokines of not-vitamin D-treated DCs. Vitamin D 22-31 interleukin 22 Homo sapiens 104-109 26107738-6 2015 Finally, we found that the differentiation of IL-22-producing T cells mediated by supernatants of vitamin D-treated DCs was dependent on TNF-alpha IL-6 and IL-23. Vitamin D 98-107 interleukin 22 Homo sapiens 46-51 26046642-4 2015 The goal of this study was to determine the prevalence of vitamin D deficiency (hypovitaminosis D) and its association with serum calcium, phosphorus, and parathyroid hormone (PTH) concentrations, disease severity, and mortality in hospitalized newborn foals. Vitamin D 58-67 parathyroid hormone Equus caballus 155-174 26131357-5 2015 FGF23 can also fine-tune vitamin D homeostasis by suppressing renal expression of 1-alpha hydroxylase (1alpha(OH)ase). Vitamin D 25-34 fibroblast growth factor 23 Homo sapiens 0-5 25938686-0 2015 Physiological functions of vitamin D: what we have learned from global and conditional VDR knockout mouse studies. Vitamin D 27-36 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 87-90 25536521-10 2015 The results of this study elucidate a possible pathway for crosstalk between two nutritionally derived lipids, vitamin D and resveratrol, both of which converge on VDR signaling. Vitamin D 111-120 vitamin D receptor Homo sapiens 164-167 26155287-1 2015 PURPOSE: According to previous studies, vitamin D exhibits protective effects against breast cancer via the vitamin D receptor (VDR). Vitamin D 40-49 vitamin D receptor Homo sapiens 108-126 26155287-1 2015 PURPOSE: According to previous studies, vitamin D exhibits protective effects against breast cancer via the vitamin D receptor (VDR). Vitamin D 40-49 vitamin D receptor Homo sapiens 128-131 25708797-1 2015 UNLABELLED: Adding to the debate around vitamin D"s effects on skeletal health, we report the long-term follow-up of two patients with severe vitamin D receptor mutations, who had normal bone mass acquisition and normalization of calcemia around puberty, suggesting that vitamin D might not be essential for skeletal health in adulthood. Vitamin D 40-49 vitamin D receptor Homo sapiens 142-160 25708797-3 2015 Individuals bearing homozygous vitamin D receptor (VDR) defects present with severe hypocalcemic rickets in early infancy due to vitamin D resistance. Vitamin D 31-40 vitamin D receptor Homo sapiens 51-54 25708797-13 2015 The normalization of calcemia and normal bone mass acquisition despite a permanently dysfunctional VDR suggest that vitamin D might not be essential for skeletal health in adulthood. Vitamin D 116-125 vitamin D receptor Homo sapiens 99-102 26296372-1 2015 Fibroblast growth factor 23 (FGF23) has emerged as an important regulator of phosphate and vitamin D homeostasis. Vitamin D 91-100 fibroblast growth factor 23 Homo sapiens 0-27 26296372-1 2015 Fibroblast growth factor 23 (FGF23) has emerged as an important regulator of phosphate and vitamin D homeostasis. Vitamin D 91-100 fibroblast growth factor 23 Homo sapiens 29-34 26296372-2 2015 It is important to understand how FGF23 interacts with vitamin D and parathyroid hormone (PTH) in a FGF23-Vitamin D-PTH axis to regulate mineral homeostasis. Vitamin D 55-64 fibroblast growth factor 23 Homo sapiens 100-105 26296372-2 2015 It is important to understand how FGF23 interacts with vitamin D and parathyroid hormone (PTH) in a FGF23-Vitamin D-PTH axis to regulate mineral homeostasis. Vitamin D 106-115 fibroblast growth factor 23 Homo sapiens 34-39 26296372-2 2015 It is important to understand how FGF23 interacts with vitamin D and parathyroid hormone (PTH) in a FGF23-Vitamin D-PTH axis to regulate mineral homeostasis. Vitamin D 106-115 fibroblast growth factor 23 Homo sapiens 100-105 26035242-11 2015 In one of the publications, it was also found that vitamin D binding protein (VDBP) has a molecular similarity to anti-sperm antibodies, and another one concluded that both low (<50 nmol/L) and high (>125 nmol/L) concentration of vitamin D are associated with decreased number and quality of spermatozoa in semen. Vitamin D 51-60 GC vitamin D binding protein Homo sapiens 78-82 25809484-2 2015 This study reports modulation of Smad signaling by the specific binding of the VDR along with its heterodimeric partner RXR to the negative vitamin D response element on the promoter of Smad7, which leads to Smad7 gene repression. Vitamin D 140-149 vitamin D receptor Homo sapiens 79-82 25809484-2 2015 This study reports modulation of Smad signaling by the specific binding of the VDR along with its heterodimeric partner RXR to the negative vitamin D response element on the promoter of Smad7, which leads to Smad7 gene repression. Vitamin D 140-149 retinoid X receptor alpha Homo sapiens 120-123 25712257-2 2015 The objectives were to (1) establish if increasing doses of vitamin D (VD) results in a proportionate dose-response in C-3 epimer; and (2) determine the biological response of bone to C-3 epimer treatment. Vitamin D 60-69 complement C3 Rattus norvegicus 119-122 26066475-1 2015 PURPOSE OF REVIEW: Fibroblast growth factor 23 (FGF23) regulates phosphate and vitamin D homeostasis and rises as kidney function declines. Vitamin D 79-88 fibroblast growth factor 23 Homo sapiens 19-46 26066475-1 2015 PURPOSE OF REVIEW: Fibroblast growth factor 23 (FGF23) regulates phosphate and vitamin D homeostasis and rises as kidney function declines. Vitamin D 79-88 fibroblast growth factor 23 Homo sapiens 48-53 25910558-0 2015 Vitamin D decreases the secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 in fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyposis. Vitamin D 0-9 matrix metallopeptidase 9 Homo sapiens 68-94 25910558-3 2015 The aim of this study was to understand the role of vitamin D in chronic rhinosinusitis with nasal polyps (CRSwNP) by investigating its effect on the secretion of matrix metalloproteinase-2 (MMP-2) and MMP-9 in nasal polyp-derived fibroblasts. Vitamin D 52-61 matrix metallopeptidase 9 Homo sapiens 202-207 25910558-10 2015 The inhibitory effect of vitamin D derivatives on MMP-2 and MMP-9 secretion could potentiate their application in pharmacotherapy of Taiwanese CRSwNP patients. Vitamin D 25-34 matrix metallopeptidase 9 Homo sapiens 60-65 25998734-5 2015 This phenotypic stability role is facilitated through the ability of vitamin D to increase the expression of both Nrf2 and the anti-ageing protein Klotho, which are also major regulators of Ca(2+) and redox signalling. Vitamin D 69-78 klotho Homo sapiens 147-153 25912039-3 2015 The in vivo effects of vitamin D on murine T cells include inhibition of T cell proliferation, inhibition of IFN-gamma, IL-17 and induction of IL-4. Vitamin D 23-32 interleukin 17A Mus musculus 120-125 25912039-9 2015 Together the data support the late effects of vitamin D on diseases like inflammatory bowel disease and multiple sclerosis where reducing IL-17 and IFN-gamma, while inducing IL-4 and IL-10, would be beneficial. Vitamin D 46-55 interleukin 17A Mus musculus 138-143 25898185-5 2015 Independent risk factors for vitamin D deficiency in HIV + patients included black race (OR 3.24, 95% CI 2.28-4.60), winter season (OR 1.39, 95% CI 1.05-1.84) and higher GFR (OR 1.01, CI 1.00-1.01); increasing age (OR 0.98, 95% CI 0.95-0.98), and tenofovir use (OR 0.72, 95% CI 0.54-0.96) were associated with less vitamin D deficiency. Vitamin D 29-38 Rap guanine nucleotide exchange factor 5 Homo sapiens 170-173 25910066-15 2015 This VDR haplotype could be useful in identifying individuals who benefit most from vitamin D chemoprevention. Vitamin D 84-93 vitamin D receptor Homo sapiens 5-8 26106480-1 2015 We studied the roles of vitamin D and its receptor, VDR, in the progression of leprosy. Vitamin D 24-33 vitamin D receptor Homo sapiens 52-55 25881523-2 2015 In recent years, the discovery of vitamin D-metabolizing enzymes and vitamin D receptor (VDR) in the lungs and various cells of the immune system has led to numerous studies conducted to evaluate its role in respiratory functions and, in particular, upper respiratory tract infections (URTIs). Vitamin D 34-43 vitamin D receptor Homo sapiens 89-92 25874538-11 2015 Vitamin D supplemented groups and rats with PTH-tissue ablation showed modestly increased parenchymal abundance of glial-fibrillary acidic protein (GFAP), a marker of astroglial activation. Vitamin D 0-9 glial fibrillary acidic protein Rattus norvegicus 115-146 25874538-11 2015 Vitamin D supplemented groups and rats with PTH-tissue ablation showed modestly increased parenchymal abundance of glial-fibrillary acidic protein (GFAP), a marker of astroglial activation. Vitamin D 0-9 glial fibrillary acidic protein Rattus norvegicus 148-152 25849303-1 2015 Vitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 66-84 25849303-1 2015 Vitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR). Vitamin D 0-9 vitamin D receptor Homo sapiens 86-89 25849303-3 2015 VDR is a critical component of the vitamin D pathway and different common single nucleotide polymorphisms have been identified. Vitamin D 35-44 vitamin D receptor Homo sapiens 0-3 25849303-8 2015 Vitamin D treatment efficacy was found to be strongly dependent on the Cdx2 VDR status in ER-negative breast cancer cell lines tested. Vitamin D 0-9 caudal type homeobox 2 Homo sapiens 71-75 25849303-8 2015 Vitamin D treatment efficacy was found to be strongly dependent on the Cdx2 VDR status in ER-negative breast cancer cell lines tested. Vitamin D 0-9 vitamin D receptor Homo sapiens 76-79 25849303-10 2015 Our results may suggest a potential effect of Cdx2 VDR polymorphism on the efficacy of vitamin D treatment in aggressive breast cancer cells (estrogen receptor negative). Vitamin D 87-96 caudal type homeobox 2 Homo sapiens 46-50 25849303-10 2015 Our results may suggest a potential effect of Cdx2 VDR polymorphism on the efficacy of vitamin D treatment in aggressive breast cancer cells (estrogen receptor negative). Vitamin D 87-96 vitamin D receptor Homo sapiens 51-54 25849303-11 2015 These results suggest that Cdx2 polymorphism may be a potential biomarker for vitamin D treatment in breast cancer, independently of the VDR receptor expression. Vitamin D 78-87 caudal type homeobox 2 Homo sapiens 27-31 25695404-3 2015 The human KL gene encodes the alpha-Klotho protein, which is a multifunctional protein that regulates the metabolism of phosphate, calcium, and vitamin D. Vitamin D 144-153 klotho Homo sapiens 10-12 25695404-3 2015 The human KL gene encodes the alpha-Klotho protein, which is a multifunctional protein that regulates the metabolism of phosphate, calcium, and vitamin D. Vitamin D 144-153 klotho Homo sapiens 36-42 25541438-0 2015 HES1-mediated inhibition of Notch1 signaling by a Gemini vitamin D analog leads to decreased CD44(+)/CD24(-/low) tumor-initiating subpopulation in basal-like breast cancer. Vitamin D 57-66 CD44 molecule (Indian blood group) Homo sapiens 93-97 25541438-3 2015 We previously reported that a Gemini vitamin D analog, 1,25-dihydroxy-20R-21(3-hydroxy-3-deuteromethyl-4,4,4-trideuterobutyl)-23-yne-26,27-hexafluoro-cholecalciferol (BXL0124), reduced CD44(+)/CD24(-/low) cells in MCF10DCIS basal-like breast cancer cells. Vitamin D 37-46 CD44 molecule (Indian blood group) Homo sapiens 185-189 25376135-3 2015 Since vitamin D acts through the vitamin D receptor (VDR), association of single nucleotide polymorphisms (SNPs) in the VDR gene might account for variations in the MS risk within populations. Vitamin D 6-15 vitamin D receptor Homo sapiens 33-51 25376135-3 2015 Since vitamin D acts through the vitamin D receptor (VDR), association of single nucleotide polymorphisms (SNPs) in the VDR gene might account for variations in the MS risk within populations. Vitamin D 6-15 vitamin D receptor Homo sapiens 53-56 25376135-3 2015 Since vitamin D acts through the vitamin D receptor (VDR), association of single nucleotide polymorphisms (SNPs) in the VDR gene might account for variations in the MS risk within populations. Vitamin D 6-15 vitamin D receptor Homo sapiens 120-123 25799011-3 2015 We selected 11 vitamin D-related genes (GC, DHCR7, CYP2R1, VDR, CYP27B1, CYP24A1, CYP27A1, RXRA, CRP2, CASR and CUBN) totaling 213 single nucleotide polymorphisms (SNPs), and examined associations with pancreatic adenocarcinoma. Vitamin D 15-24 cubilin Homo sapiens 112-116 25448751-14 2015 Vitamin D regulating enzymes (CYP24A1, CYP2R1 and CYP27B1) expression were also altered in women with 25(OH)D3 deficiency. Vitamin D 0-9 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 30-37 25499229-2 2015 Pleiotropic actions of vitamin D and its analogs are mediated by vitamin D receptor (VDR). Vitamin D 23-32 vitamin D receptor Homo sapiens 65-83 25499229-2 2015 Pleiotropic actions of vitamin D and its analogs are mediated by vitamin D receptor (VDR). Vitamin D 23-32 vitamin D receptor Homo sapiens 85-88 25499229-4 2015 The FokI and BsmI polymorphisms of the VDR gene are regarded as strong markers of disturbed vitamin D signaling pathway. Vitamin D 92-101 vitamin D receptor Homo sapiens 39-42 25662556-10 2015 Apoptosis induction of VDR+ cells in oral precancerous lesions and OSCC by natural vitamin D or synthetic vitamin D compounds could be useful for chemoprevention. Vitamin D 83-92 vitamin D receptor Homo sapiens 23-26 25662556-10 2015 Apoptosis induction of VDR+ cells in oral precancerous lesions and OSCC by natural vitamin D or synthetic vitamin D compounds could be useful for chemoprevention. Vitamin D 106-115 vitamin D receptor Homo sapiens 23-26 25294851-0 2015 The induction of C/EBPbeta contributes to vitamin D inhibition of ADAM17 expression and parathyroid hyperplasia in kidney disease. Vitamin D 42-51 ADAM metallopeptidase domain 17 Homo sapiens 66-72 25294851-8 2015 Importantly, in rat SHPT, the correction of vitamin D deficiency effectively reversed the resistance to paricalcitol induction of C/EBPbeta to suppress ADAM17 expression and PTG enlargement, reducing PTH by 50%. Vitamin D 44-53 CCAAT/enhancer binding protein beta Rattus norvegicus 130-139 25294851-9 2015 CONCLUSION: In SHPT, correction of vitamin D and calcitriol deficiency induces parathyroid C/EBPbeta to efficaciously attenuate the severe ADAM17/TGFalpha synergy, which drives PTG enlargement and high PTH. Vitamin D 35-44 ADAM metallopeptidase domain 17 Homo sapiens 139-145 25324357-2 2015 In rats, systemic inhibition of epidermal growth factor receptor (EGFR) activation markedly attenuated uremia-induced parathyroid hyperplasia and vitamin D receptor (VDR) loss, hence restoring the response to vitamin D. Vitamin D 146-155 epidermal growth factor receptor Rattus norvegicus 32-64 25324357-2 2015 In rats, systemic inhibition of epidermal growth factor receptor (EGFR) activation markedly attenuated uremia-induced parathyroid hyperplasia and vitamin D receptor (VDR) loss, hence restoring the response to vitamin D. Vitamin D 146-155 epidermal growth factor receptor Rattus norvegicus 66-70 25366373-0 2015 Associations between the levels of sclerostin, phosphate, and fibroblast growth factor-23 and treatment with vitamin D in hemodialysis patients with low intact PTH level. Vitamin D 109-118 fibroblast growth factor 23 Homo sapiens 62-89 25028176-11 2015 This could be due to low maternal vitamin D levels in patients with GDM because in vitro low calcitriol doses upregulate VDR in trophoblast cells. Vitamin D 34-43 vitamin D receptor Homo sapiens 121-124 25730037-1 2015 The vitamin D (1,25-dihydroxyvitamin D3) receptor (VDR) gene encodes a protein that functions in the transcriptional regulation of vitamin D-responsive genes and plays a role in innate immunity and adaptive immune responses. Vitamin D 4-13 vitamin D receptor Homo sapiens 51-54 25667505-9 2015 First results suggest that both the number of genome-wide VDR binding sites and the expression of VDR target genes correlate with vitamin D status of the studied human individuals. Vitamin D 130-139 vitamin D receptor Homo sapiens 58-61 25667505-9 2015 First results suggest that both the number of genome-wide VDR binding sites and the expression of VDR target genes correlate with vitamin D status of the studied human individuals. Vitamin D 130-139 vitamin D receptor Homo sapiens 98-101 25461390-7 2015 Supplemental vitamin D increased interferon (IFN)-gamma and interleukin (IL)-10 in subjects that were vitamin D insufficient (serum 25(OH)D<29ng/mL) compared to sufficient (serum 25(OH)D>=30ng/mL) at Bsl. Vitamin D 13-22 interleukin 10 Homo sapiens 60-79 25375986-1 2015 CONTEXT: Mutations of the CYP24A1 gene encoding the 24-hydroxylase (24OHase) that inactivates metabolites of vitamin D can cause hypercalcemia in infants and adults; in vitro assays of 24OHase activity have been difficult. Vitamin D 109-118 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 26-33 25375986-1 2015 CONTEXT: Mutations of the CYP24A1 gene encoding the 24-hydroxylase (24OHase) that inactivates metabolites of vitamin D can cause hypercalcemia in infants and adults; in vitro assays of 24OHase activity have been difficult. Vitamin D 109-118 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 68-75 25375986-1 2015 CONTEXT: Mutations of the CYP24A1 gene encoding the 24-hydroxylase (24OHase) that inactivates metabolites of vitamin D can cause hypercalcemia in infants and adults; in vitro assays of 24OHase activity have been difficult. Vitamin D 109-118 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 185-192 25375986-2 2015 OBJECTIVE: We sought an alternative assay to characterize a CYP24A1 mutation in a young adult with bilateral nephrolithiasis and hypercalcemia associated with ingestion of excess vitamin D supplements and robust dairy intake for 5 years. Vitamin D 179-188 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 60-67 25375986-10 2015 Heterozygous mutation of CYP24A1 may cause hypercalcemia in the setting of excessive vitamin D intake, but it is also possible that the patient had another, unidentified CYP24A1 mutation on the other allele. Vitamin D 85-94 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 25-32 25645983-0 2015 Vitamin D decreases the secretion of eotaxin and RANTES in nasal polyp fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyps. Vitamin D 0-9 C-C motif chemokine ligand 5 Homo sapiens 49-55 25645983-12 2015 Therefore, the inhibitory effect of vitamin D derivatives on eotaxin and RANTES secretion might shed light not only on the disease mechanism, but also on the potential use of vitamin D in pharmacotherapy of Taiwanese patients with CRSwNP. Vitamin D 36-45 C-C motif chemokine ligand 5 Homo sapiens 73-79 25581929-0 2015 Vitamin D and actigraphic sleep outcomes in older community-dwelling men: the MrOS sleep study. Vitamin D 0-9 MROS Homo sapiens 78-82 25563643-1 2015 BACKGROUND AND PURPOSE: Fibroblast growth factor 23 (FGF23) is a hormone that regulates phosphorus and vitamin D metabolism. Vitamin D 103-112 fibroblast growth factor 23 Homo sapiens 24-51 25563643-1 2015 BACKGROUND AND PURPOSE: Fibroblast growth factor 23 (FGF23) is a hormone that regulates phosphorus and vitamin D metabolism. Vitamin D 103-112 fibroblast growth factor 23 Homo sapiens 53-58