PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
12548710-1	2003	Heme oxygenase-1 (HO1) catalyzes oxidation of the heme molecule in concert with NADPH-cytochrome P450 reductase following the specific cleavage of heme into carbon monoxide, iron, and biliverdin, which is rapidly metabolized to bilirubin.	Bilirubin	228-237	heme oxygenase 1	Rattus norvegicus	0-16
12548710-1	2003	Heme oxygenase-1 (HO1) catalyzes oxidation of the heme molecule in concert with NADPH-cytochrome P450 reductase following the specific cleavage of heme into carbon monoxide, iron, and biliverdin, which is rapidly metabolized to bilirubin.	Bilirubin	228-237	heme oxygenase 1	Rattus norvegicus	18-21
12548710-1	2003	Heme oxygenase-1 (HO1) catalyzes oxidation of the heme molecule in concert with NADPH-cytochrome P450 reductase following the specific cleavage of heme into carbon monoxide, iron, and biliverdin, which is rapidly metabolized to bilirubin.	Bilirubin	228-237	cytochrome p450 oxidoreductase	Rattus norvegicus	80-111
12548710-6	2003	These results suggest that bilirubin has essentially a neuroprotective effect against focal ischemia and may participate in HO1-induced neuroprotection.	Bilirubin	27-36	heme oxygenase 1	Rattus norvegicus	124-127
12524417-4	2003	Immunostaining for the canalicular transporter, multidrug resistant protein 2 (MRP2), responsible for biliary secretion of several organic anions including bilirubin glucuronides, showed sustained expression in both biopsies as well as relocalisation with appearance of strong staining of the basolateral membrane of the hepatocyte.	Bilirubin	156-165	ATP binding cassette subfamily C member 2	Homo sapiens	79-83
12595889-4	2003	Progressive repopulation of the liver by engrafted UGT1A1-proficient hepatocytes over 5 months was demonstrated by the appearance of UGT1A1 protein and enzyme activity in the liver, biliary bilirubin glucuronides secretion, and long-term normalization of serum bilirubin levels.	Bilirubin	190-199	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	51-57
12595889-4	2003	Progressive repopulation of the liver by engrafted UGT1A1-proficient hepatocytes over 5 months was demonstrated by the appearance of UGT1A1 protein and enzyme activity in the liver, biliary bilirubin glucuronides secretion, and long-term normalization of serum bilirubin levels.	Bilirubin	261-270	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	51-57
14753445-0	2003	Transient elevation of serum bilirubin (a heme oxygenase-1 metabolite) level in hemorrhagic stroke: bilirubin is a marker of oxidant stress.	Bilirubin	29-38	heme oxygenase 1	Homo sapiens	42-58
12441340-6	2003	Furthermore, binding of the nonsubstrate ligands, bilirubin or 13-cis-retinal, to L-PGDS changed from a multistate mode in the native form of L-PGDS to a simple two-state mode in the activity-enhanced form, as monitored by CD spectra of the bound ligands.	Bilirubin	50-59	prostaglandin D2 synthase	Homo sapiens	82-88
12441340-6	2003	Furthermore, binding of the nonsubstrate ligands, bilirubin or 13-cis-retinal, to L-PGDS changed from a multistate mode in the native form of L-PGDS to a simple two-state mode in the activity-enhanced form, as monitored by CD spectra of the bound ligands.	Bilirubin	50-59	prostaglandin D2 synthase	Homo sapiens	142-148
14753445-0	2003	Transient elevation of serum bilirubin (a heme oxygenase-1 metabolite) level in hemorrhagic stroke: bilirubin is a marker of oxidant stress.	Bilirubin	100-109	heme oxygenase 1	Homo sapiens	42-58
14753445-2	2003	The production of Bil reflects heme oxygenase-1 expression in response to oxidative stress in various diseases.	Bilirubin	18-21	heme oxygenase 1	Homo sapiens	31-47
12464260-5	2003	Here we describe diverse roles of CAR in hepatic gene expression with a particular focus on endogenous substances such as cholesterol, bilirubin, and steroid hormones.	Bilirubin	135-144	nuclear receptor subfamily 1, group I, member 3	Mus musculus	34-37
12388433-2	2003	Mutations in human MRP2 result in defects in excretion of conjugated bilirubin and other cholephiles known as the Dubin-Johnson syndrome.	Bilirubin	69-78	ATP binding cassette subfamily C member 2	Homo sapiens	19-23
12964953-5	2003	HO-1 and its constitutively expressed isozyme, heme oxygenase-2, catalyze the rate-limiting step in the conversion of heme to its metabolites, bilirubin IXalpha, ferrous iron, and carbon monoxide (CO).	Bilirubin	143-160	heme oxygenase 1	Homo sapiens	0-4
15115285-1	2003	Heat shock protein 32 (Hsp32, hemoxygenase-1) is induced by reactive oxygen metabolites (ROM) and degrades heme leading to the formation of antioxidant bilirubin.	Bilirubin	152-161	heme oxygenase 1	Homo sapiens	0-21
15115285-1	2003	Heat shock protein 32 (Hsp32, hemoxygenase-1) is induced by reactive oxygen metabolites (ROM) and degrades heme leading to the formation of antioxidant bilirubin.	Bilirubin	152-161	heme oxygenase 1	Homo sapiens	23-28
12552319-0	2003	Oxytocin infusion in labor: the effect different indications and the use of different diluents on neonatal bilirubin levels.	Bilirubin	107-116	oxytocin/neurophysin I prepropeptide	Homo sapiens	0-8
12552319-1	2003	OBJECTIVE: To investigate the relationship of neonatal bilirubin levels to oxytocin infusion and the diluent used for oxytocin infusion.	Bilirubin	55-64	oxytocin/neurophysin I prepropeptide	Homo sapiens	75-83
12545001-10	2003	ACR was associated with intensive care unit stay (p =.0021) and highest serum C-reactive protein (p =.0002), serum creatinine (p <.0001), and bilirubin (p =.0009).	Bilirubin	145-154	acrosin	Homo sapiens	0-3
12630024-9	2003	Using Cox regression analysis and selecting AST and log of total bilirubin, a prognostic index was defined: prognostic index 0.006 (AST-83.044) + 0.638 [log of total bilirubin-0.1175].	Bilirubin	65-74	solute carrier family 17 member 5	Homo sapiens	132-135
12480553-4	2003	UGT1A1*28 is associated with Gilbert"s syndrome, a deficiency in glucuronidation of bilirubin leading to mild hyperbilirubinemia, whereas UGT1A6*2 may result in low glucuronidation rates of several drugs.	Bilirubin	84-93	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
12480553-6	2003	RESULTS: Associations were found between UGT enzyme activities of bilirubin (B) and 4-nitrophenol (NP; r=0.47, P=0.0024), B and 4-methylumbelliferone (MUB; r=0.54, P=0.0003), and NP and MUB (r=0.89, P<0.0001).	Bilirubin	66-75	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	41-44
12964953-5	2003	HO-1 and its constitutively expressed isozyme, heme oxygenase-2, catalyze the rate-limiting step in the conversion of heme to its metabolites, bilirubin IXalpha, ferrous iron, and carbon monoxide (CO).	Bilirubin	143-160	heme oxygenase 2	Homo sapiens	47-63
12433804-2	2002	Although UGT1A1 uniquely catalyzes the glucuronidation of the endobiotic, bilirubin, and UGT2B7 uniquely catalyzes the glucuronidation of morphine to both the 3-0 glucuronide and the 6-0 glucuronide, both catalyze the glucuronidation of the mixed opioid agonist/antagonist buprenorphine with high efficiency.	Bilirubin	74-83	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	9-15
12466075-7	2002	Patients with the UGT1A1 TA*7/TA*7 genotype showed higher mean serum bilirubin levels than did patients who were homozygous for the wild-type allele (Mann-Whitney test 35.5; p < 0.05).	Bilirubin	69-78	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	18-24
12517055-9	2002	Increased expression of MUC1 was found in gallbladders with cholesterol stones (79%) and calcium bilirubinate stones (83%) compared to those without stones (30%).	Bilirubin	89-109	mucin 1, cell surface associated	Homo sapiens	24-28
12433820-11	2002	The troglitazone glucuronosyltransferase activity in pooled human liver microsomes was strongly inhibited by bilirubin (IC(50) = 1.9 micro M), a typical substrate of UGT1A1.	Bilirubin	109-118	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	166-172
12433820-14	2002	The troglitazone glucuronosyltransferase activity in human jejunum microsomes was strongly inhibited by emodin (IC(50) = 15.6 micro M), a typical substrate of UGT1A8 and UGT1A10, rather than by bilirubin (IC(50) = 154.0 micro M).	Bilirubin	194-203	UDP glucuronosyltransferase family 1 member A8	Homo sapiens	159-165
12433823-7	2002	Nicotine and cotinine N-glucuronidations in pooled human liver microsomes were competitively inhibited by bilirubin as a substrate for UGT1A1 (K(i) = 3.9 and 3.3 micro M), imipramine as a substrate for UGT1A4 (K(i) = 6.1 and 2.7 micro M), and propofol as a substrate for UGT1A9 (K(i) = 6.0 and 12.0 micro M).	Bilirubin	106-115	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	135-141
12433823-7	2002	Nicotine and cotinine N-glucuronidations in pooled human liver microsomes were competitively inhibited by bilirubin as a substrate for UGT1A1 (K(i) = 3.9 and 3.3 micro M), imipramine as a substrate for UGT1A4 (K(i) = 6.1 and 2.7 micro M), and propofol as a substrate for UGT1A9 (K(i) = 6.0 and 12.0 micro M).	Bilirubin	106-115	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	202-208
12433823-7	2002	Nicotine and cotinine N-glucuronidations in pooled human liver microsomes were competitively inhibited by bilirubin as a substrate for UGT1A1 (K(i) = 3.9 and 3.3 micro M), imipramine as a substrate for UGT1A4 (K(i) = 6.1 and 2.7 micro M), and propofol as a substrate for UGT1A9 (K(i) = 6.0 and 12.0 micro M).	Bilirubin	106-115	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	271-277
12447873-5	2002	One week after BDL, IFN-gammaR(1)+/+ mice showed less severe jaundice and liver injury than IFN-gammaR(1)-/- mice, as reflected by lower bilirubin and liver enzyme levels.	Bilirubin	137-146	interferon gamma receptor 1	Mus musculus	20-30
12447873-5	2002	One week after BDL, IFN-gammaR(1)+/+ mice showed less severe jaundice and liver injury than IFN-gammaR(1)-/- mice, as reflected by lower bilirubin and liver enzyme levels.	Bilirubin	137-146	interferon gamma receptor 1	Mus musculus	20-33
12558139-7	2003	In the bacteremic group, there was an inverse correlation between CD40 expression and bilirubin levels (r2 = 0.52, P = 0.004) and plasma IL-6 concentrations (r2 = 0.30, P = 0.04).	Bilirubin	86-95	CD40 molecule	Homo sapiens	66-70
12386134-4	2002	Although the classic UGT1A1 substrate bilirubin was a weak competitive inhibitor of estradiol-3-glucuronidation, the estrogens and anthraflavic acid activated or inhibited estradiol-3-glucuronidation dependent on substrate and effector concentrations.	Bilirubin	38-47	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	21-27
12449100-1	2002	Heme oxygenase 1 (HO-1) is an inducible enzyme that catalyzes heme to generate bilirubin, ferritin, and carbon monoxide.	Bilirubin	79-88	heme oxygenase 1	Mus musculus	0-16
12449100-1	2002	Heme oxygenase 1 (HO-1) is an inducible enzyme that catalyzes heme to generate bilirubin, ferritin, and carbon monoxide.	Bilirubin	79-88	heme oxygenase 1	Mus musculus	18-22
12517055-4	2002	In this study, we evaluated mucin gene expression in gallbladders containing cholesterol stones or calcium bilirubinate stones, and gallbladders without stones.	Bilirubin	99-119	LOC100508689	Homo sapiens	28-33
12517055-10	2002	CONCLUSION: Altered mucin gene expression was found in gallbladders with cholesterol stones and calcium bilirubinate stones, as evidenced by the presence of MUC2 and MUC4 and the increased expression of MUC1, MUC3, MUC5B and MUC6.	Bilirubin	96-116	LOC100508689	Homo sapiens	20-25
12439224-1	2002	UDP-glucuronosyltransferase 1A1 (UGT1A1) is a polymorphic enzyme responsible for the glucuronidation of structurally diverse drugs, non-drug xenobiotics and endogenous compounds (e.g. bilirubin).	Bilirubin	184-193	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-31
12439224-1	2002	UDP-glucuronosyltransferase 1A1 (UGT1A1) is a polymorphic enzyme responsible for the glucuronidation of structurally diverse drugs, non-drug xenobiotics and endogenous compounds (e.g. bilirubin).	Bilirubin	184-193	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	33-39
12439228-2	2002	The mean (SD) value of serum bilirubin in the subjects with G6PD deficiency and homozygous variation in UGT1A1 gene was 51.3 (17.8) micromol/l, which was significantly higher compared to that in the other five subgroups.	Bilirubin	29-38	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	104-110
12378576-1	2002	Crigler-Najjar syndrome type I (CN-I) is a rare and severe inherited disorder of bilirubin metabolism, caused by the total deficiency of bilirubin-UDP-glucuronosyltransferase (UGT) activity.	Bilirubin	81-90	5'-nucleotidase, cytosolic IA	Homo sapiens	32-36
12357057-0	2002	Relationship between bilirubin UDP-glucuronosyl transferase 1A1 gene and neonatal hyperbilirubinemia.	Bilirubin	21-30	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	31-63
12378576-1	2002	Crigler-Najjar syndrome type I (CN-I) is a rare and severe inherited disorder of bilirubin metabolism, caused by the total deficiency of bilirubin-UDP-glucuronosyltransferase (UGT) activity.	Bilirubin	81-90	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	137-174
12378576-1	2002	Crigler-Najjar syndrome type I (CN-I) is a rare and severe inherited disorder of bilirubin metabolism, caused by the total deficiency of bilirubin-UDP-glucuronosyltransferase (UGT) activity.	Bilirubin	81-90	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	176-179
12220528-6	2002	Our findings show that the absence of UGT1 protein from Gunn rat hepatocytes is due to rapid degradation of the truncated UGT1 protein by the proteasome and elucidate the molecular basis underlying the deficiency in bilirubin glucuronidation.	Bilirubin	216-225	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	38-42
12204357-9	2002	Immunoreactive staining for the calcium-binding proteins calbindin and parvalbumin in lower brainstem auditory nuclei shows abnormalities in areas susceptible to the effects of hyperbilirubinemia and provides a sensitive new way to assess bilirubin toxicity in the auditory system.	Bilirubin	182-191	calbindin 1	Rattus norvegicus	57-66
12218538-1	2002	BACKGROUND: Although precise mechanisms remain to be determined, recent studies show that heme oxygenase-1 (HO-1), providing endogenous carbon monoxide (CO) and bilirubin, serves as an antiinflammatory enzyme.	Bilirubin	161-170	heme oxygenase 1	Rattus norvegicus	90-106
12218538-1	2002	BACKGROUND: Although precise mechanisms remain to be determined, recent studies show that heme oxygenase-1 (HO-1), providing endogenous carbon monoxide (CO) and bilirubin, serves as an antiinflammatory enzyme.	Bilirubin	161-170	heme oxygenase 1	Rattus norvegicus	108-112
12204357-9	2002	Immunoreactive staining for the calcium-binding proteins calbindin and parvalbumin in lower brainstem auditory nuclei shows abnormalities in areas susceptible to the effects of hyperbilirubinemia and provides a sensitive new way to assess bilirubin toxicity in the auditory system.	Bilirubin	182-191	parvalbumin	Rattus norvegicus	71-82
12124217-1	2002	Heme oxygenase (HO)-1 converts heme to bilirubin, carbon monoxide, and iron.	Bilirubin	39-48	heme oxygenase 1	Mus musculus	0-21
12198827-5	2002	Bilirubin-uridinediphosphate-glucuronosyltransferase (UGT1A1) is the only enzyme involved in the conjugation of bilirubin.	Bilirubin	112-121	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	54-60
12190180-6	2002	The percentage of XOR oxidase activity in cirrhotic liver, regardless of virus infection, correlated positively with aspartate amino-transferase, bilirubin concentration, and partial thromboplastin time, and negatively with prothrombin time.	Bilirubin	146-155	xanthine dehydrogenase	Homo sapiens	18-21
12230871-4	2002	HO-1 cleaves the porphyrin macrocycle of heme at the expense of molecular oxygen to release a linear tetrapyrrole biliverdin, carbon monoxide, and ferrous iron; biliverdin is rapidly reduced to bilirubin.	Bilirubin	194-203	heme oxygenase 1	Homo sapiens	0-4
12230873-2	2002	The importance of this protein in physiology and disease is underlined by the versatility of HO-1 inducers and the functional role attributed to HO-1 products (carbon monoxide and bilirubin) in conditions that are associated with moderate or severe cellular stress.	Bilirubin	180-189	heme oxygenase 1	Homo sapiens	145-149
12230868-3	2002	HO-1 is a cytoprotective enzyme that degrades heme, a potent oxidant, to generate carbon monoxide, biliverdin (subsequently reduced to bilirubin), and iron.	Bilirubin	135-144	heme oxygenase 1	Homo sapiens	0-4
12101428-3	2002	We have constructed a recombinant adenovirus, Ad-hUGT1A1-CTLA4Ig that coexpresses human bilirubin-uridinediphosphoglucuronate glucuronosyltransferase (hUGT1A1) and soluble murine CTLA4Ig, both driven by CMV immediate-early promoters.	Bilirubin	88-97	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	49-56
12101428-3	2002	We have constructed a recombinant adenovirus, Ad-hUGT1A1-CTLA4Ig that coexpresses human bilirubin-uridinediphosphoglucuronate glucuronosyltransferase (hUGT1A1) and soluble murine CTLA4Ig, both driven by CMV immediate-early promoters.	Bilirubin	88-97	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	57-62
12101428-3	2002	We have constructed a recombinant adenovirus, Ad-hUGT1A1-CTLA4Ig that coexpresses human bilirubin-uridinediphosphoglucuronate glucuronosyltransferase (hUGT1A1) and soluble murine CTLA4Ig, both driven by CMV immediate-early promoters.	Bilirubin	88-97	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	151-158
12101428-7	2002	A second injection of Ad-hUGT1A1-CTLA4Ig normalized serum bilirubin.	Bilirubin	58-67	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	25-32
12101428-12	2002	In contrast, after Ad-hUGT1A1 (which expresses UGT1A1 alone) injection, serum bilirubin remained normal for only 4 weeks, and returned to preinjection levels by day 120.	Bilirubin	78-87	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	22-29
12101428-12	2002	In contrast, after Ad-hUGT1A1 (which expresses UGT1A1 alone) injection, serum bilirubin remained normal for only 4 weeks, and returned to preinjection levels by day 120.	Bilirubin	78-87	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	23-29
12238138-2	2002	Administration of CCl4 (0.7 ml/kg body weight for 7 days) produces damage in the liver as evident by estimation of enzymes such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transminase (SGPT) and alkaline phosphatase (ALP) as well as serum bilirubin level.	Bilirubin	273-282	C-C motif chemokine ligand 4	Rattus norvegicus	18-22
12153725-5	2002	The mRNA of UGT1A1, which is an isoform contributing to the glucuronidation of bilirubin, increased significantly in the liver and slightly in the kidney after hypophysectomy.	Bilirubin	79-88	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	12-18
12403228-6	2002	In the cases without obvious hemolytic or hepatic complications, G-6-PD deficient cases had mildly but significantly higher total birirubin and indirect bilirubin, as well as a lower hematocrit than those who had normal G-6-PD.	Bilirubin	153-162	glucose-6-phosphate dehydrogenase	Homo sapiens	65-71
12143206-5	2002	The increase in portal interleukin-6 levels during liver resection (time points, ii and iii) significantly correlated with the duration of hepatic inflow occlusion (48 +/- 9 min, mean +/- SD), portal venous pressure (500 +/- 127 mmH2O), and postoperative serum levels of transaminases (day 1; S-ALT, 705 +/- 1023 U/L; S-AST 892 +/- 1255 U/L) and maximum bilirubin (2.6 +/- 2.5 mg/dL).	Bilirubin	354-363	interleukin 6	Homo sapiens	23-36
12130676-5	2002	Caspase-3 activity and cytochrome c release from mitochondria increased at 3 h post-treatment, before increased caspase-8 activity at 6 h, and nuclear condensation by 24 h after treatment with bilirubin.	Bilirubin	193-202	caspase 3	Mus musculus	0-9
12130676-5	2002	Caspase-3 activity and cytochrome c release from mitochondria increased at 3 h post-treatment, before increased caspase-8 activity at 6 h, and nuclear condensation by 24 h after treatment with bilirubin.	Bilirubin	193-202	caspase 8	Mus musculus	112-121
12130676-7	2002	Pretreatment of cells for 1 h with 1 or 10 microM alpha-naphthoflavone, an AHR antagonist, before bilirubin exposure resulted in decreased caspase-3 activity at 6 h and nuclear condensation at 24 h in WT cells.	Bilirubin	98-107	aryl-hydrocarbon receptor	Mus musculus	75-78
12130676-8	2002	These results indicate that bilirubin, a potential AHR ligand, causes apoptosis in murine Hepa 1c1c7 WT cells by a mechanism(s) partially involving the AHR, disruption of membrane integrity, and increased intracellular ROS production.	Bilirubin	28-37	aryl-hydrocarbon receptor	Mus musculus	51-54
12130676-8	2002	These results indicate that bilirubin, a potential AHR ligand, causes apoptosis in murine Hepa 1c1c7 WT cells by a mechanism(s) partially involving the AHR, disruption of membrane integrity, and increased intracellular ROS production.	Bilirubin	28-37	aryl-hydrocarbon receptor	Mus musculus	152-155
12208202-4	2002	Here I suggest the impaired inactivation of digestive proteases by deconjugated bilirubin, as the result of the inhibition of bilirubin deconjugation enzyme, beta-glucuronidase, originated from the luminal bacteria and mucosa of the gut, to be a possible mechanism for both ulcerative colitis and Crohn"s diseases.	Bilirubin	80-89	glucuronidase beta	Homo sapiens	158-176
12208202-4	2002	Here I suggest the impaired inactivation of digestive proteases by deconjugated bilirubin, as the result of the inhibition of bilirubin deconjugation enzyme, beta-glucuronidase, originated from the luminal bacteria and mucosa of the gut, to be a possible mechanism for both ulcerative colitis and Crohn"s diseases.	Bilirubin	126-135	glucuronidase beta	Homo sapiens	158-176
12174378-13	2002	Before the treatment, ALT AST activity and total bilirubin content of patients who had regression of fibrosis after oral administration of SA-B, were significantly lower than those of patients who had aggravation of fibrosis after oral administration of SA-B.	Bilirubin	49-58	SH3 domain binding protein 5	Homo sapiens	139-143
12068294-3	2002	Here we show that Rdx(-/-) mice are normal at birth, but their serum concentrations of conjugated bilirubin begin to increase gradually around 4 weeks, and they show mild liver injury after 8 weeks.	Bilirubin	98-107	radixin	Mus musculus	18-21
12068294-5	2002	In wildtype mice, Mrp2 concentrates at BCMs to secrete conjugated bilirubin into bile.	Bilirubin	66-75	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	18-22
12068294-8	2002	These findings indicate that radixin is required for secretion of conjugated bilirubin through its support of Mrp2 localization at BCMs.	Bilirubin	77-86	radixin	Mus musculus	29-36
12068294-8	2002	These findings indicate that radixin is required for secretion of conjugated bilirubin through its support of Mrp2 localization at BCMs.	Bilirubin	77-86	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	110-114
12222668-2	2002	The present study was to test whether ingestion of OGT extract (TJ-15) would affect the metabolism of fatty acids and the usual antioxidant molecule (such as albumin, uric acid and bilirubin) levels in human plasma.	Bilirubin	181-190	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	51-54
12093957-9	2002	CONCLUSION: In DAT-negative newborns with significant jaundice or increased bilirubin production, even if ABO-incompatible, a cause other than isoimmunization should be sought.	Bilirubin	76-85	solute carrier family 6 member 3	Homo sapiens	15-18
12499798-6	2002	METHODS: Promoter regions of the gene for bilirubin UGT-1A1 in twelve patients with Gilbert"s syndrome and twenty healthy subjects (controls) were sequenced.	Bilirubin	42-51	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	52-59
12078936-0	2002	Predicting the risk of sporadic elevated bilirubin levels and diagnosing Gilbert"s syndrome by genotyping UGT1A1*28 promoter polymorphism.	Bilirubin	41-50	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	106-112
12051994-11	2002	Heme metabolism via HO-1 generates biliverdin, which is rapidly converted to bilirubin by biliverdin reductase.	Bilirubin	77-86	heme oxygenase 1	Rattus norvegicus	20-24
11916968-2	2002	In this report, we demonstrate that transgenic mice expressing ATF3 in the liver had symptoms of liver dysfunction such as high levels of serum bilirubin, alkaline phosphatase, alanine transaminase, aspartate transaminase, and bile acids.	Bilirubin	144-153	activating transcription factor 3	Mus musculus	63-67
12084558-1	2002	The canalicular multidrug resistance protein 2 (MRP2; gene symbol: ABCC2) mediates ATP-dependent biliary excretion of organic anions such as bilirubin diglucuronide, glutathione conjugates and sulfated and glucuronidated bile salts.	Bilirubin	141-150	ATP binding cassette subfamily C member 2	Homo sapiens	4-44
11983459-0	2002	Crigler-Najjar syndrome type II in a caucasian patient resulting from two mutations in the bilirubin uridine 5"-diphosphate-glucuronosyltransferase (UGT1A1) gene.	Bilirubin	91-100	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	149-155
12078936-3	2002	The aim of this investigation was to evaluate the correlation of unspecific elevated bilirubin levels and the occurrence of GS with a described polymorphism in the uridine diphosphat glucuronosyltransferase 1A1 (UGT1A1) in a predominately Caucasian population.	Bilirubin	85-94	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	164-210
12078936-3	2002	The aim of this investigation was to evaluate the correlation of unspecific elevated bilirubin levels and the occurrence of GS with a described polymorphism in the uridine diphosphat glucuronosyltransferase 1A1 (UGT1A1) in a predominately Caucasian population.	Bilirubin	85-94	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	212-218
12078936-10	2002	Genotyping of the UGT1A1 promoter polymorphism is a cheap and unequivocal method for predicting elevated and fluctuating bilirubin levels.	Bilirubin	121-130	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	18-24
11981769-5	2002	Consistent with this observation, caspase-3 was activated and the full-length substrate poly(ADP)ribose polymerase (PARP) degraded, even in the presence of very modestly elevated concentrations of bilirubin.	Bilirubin	197-206	caspase 3	Rattus norvegicus	34-43
11981769-5	2002	Consistent with this observation, caspase-3 was activated and the full-length substrate poly(ADP)ribose polymerase (PARP) degraded, even in the presence of very modestly elevated concentrations of bilirubin.	Bilirubin	197-206	poly (ADP-ribose) polymerase 1	Rattus norvegicus	88-114
11981769-7	2002	Further experiments showed that bilirubin diminished mitochondrial transmembrane potential (DeltaPsi(m)) and increased mitochondrial-associated Bax protein levels, while directly disrupting membrane lipid and protein structure.	Bilirubin	32-41	BCL2 associated X, apoptosis regulator	Rattus norvegicus	144-147
11981769-8	2002	In conclusion, bilirubin induces mitochondrial depolarization and Bax translocation via physical interaction with membranes, mediating the mitochondrial pathway of apoptosis in neurons exposed to bilirubin.	Bilirubin	15-24	BCL2 associated X, apoptosis regulator	Rattus norvegicus	66-69
11981769-8	2002	In conclusion, bilirubin induces mitochondrial depolarization and Bax translocation via physical interaction with membranes, mediating the mitochondrial pathway of apoptosis in neurons exposed to bilirubin.	Bilirubin	196-205	BCL2 associated X, apoptosis regulator	Rattus norvegicus	66-69
11971948-7	2002	IL-4(-/-) deficiency also increased serum concentrations of bilirubin following feeding a fat-enriched diet.	Bilirubin	60-69	interleukin 4	Mus musculus	0-4
12084558-1	2002	The canalicular multidrug resistance protein 2 (MRP2; gene symbol: ABCC2) mediates ATP-dependent biliary excretion of organic anions such as bilirubin diglucuronide, glutathione conjugates and sulfated and glucuronidated bile salts.	Bilirubin	141-150	ATP binding cassette subfamily C member 2	Homo sapiens	48-52
12084558-1	2002	The canalicular multidrug resistance protein 2 (MRP2; gene symbol: ABCC2) mediates ATP-dependent biliary excretion of organic anions such as bilirubin diglucuronide, glutathione conjugates and sulfated and glucuronidated bile salts.	Bilirubin	141-150	ATP binding cassette subfamily C member 2	Homo sapiens	67-72
12006180-4	2002	Hypoxia transiently increases the transcriptional rate of the heme oxygenase-1 (HO-1) gene, resulting in increased production of carbon monoxide (CO) and bilirubin.	Bilirubin	154-163	heme oxygenase 1	Homo sapiens	62-78
11897625-15	2002	The mRNA expression of MRP2 increased in renal proximal tubular epithelial cells after treatment with conjugated bilirubin, sulfate-conjugated bile acid or human bile.	Bilirubin	113-122	ATP binding cassette subfamily C member 2	Homo sapiens	23-27
11897625-16	2002	Upregulation of MRP2 in the kidneys and MRP3 in the liver may be a compensatory mechanism to improve bilirubin clearance during obstructive jaundice.	Bilirubin	101-110	ATP binding cassette subfamily C member 2	Rattus norvegicus	16-20
11897625-16	2002	Upregulation of MRP2 in the kidneys and MRP3 in the liver may be a compensatory mechanism to improve bilirubin clearance during obstructive jaundice.	Bilirubin	101-110	ATP binding cassette subfamily C member 3	Rattus norvegicus	40-44
11897632-1	2002	Multidrug resistance-associated protein 3 (MRP3; symbol ABCC3), has been shown to mediate ATP-dependent transport of organic anions including 17beta-glucuronosyl estradiol, glucuronosyl bilirubin, monovalent, and sulfated bile salts.	Bilirubin	186-195	ATP binding cassette subfamily C member 3	Rattus norvegicus	0-41
11897632-1	2002	Multidrug resistance-associated protein 3 (MRP3; symbol ABCC3), has been shown to mediate ATP-dependent transport of organic anions including 17beta-glucuronosyl estradiol, glucuronosyl bilirubin, monovalent, and sulfated bile salts.	Bilirubin	186-195	ATP binding cassette subfamily C member 3	Rattus norvegicus	43-47
11897632-1	2002	Multidrug resistance-associated protein 3 (MRP3; symbol ABCC3), has been shown to mediate ATP-dependent transport of organic anions including 17beta-glucuronosyl estradiol, glucuronosyl bilirubin, monovalent, and sulfated bile salts.	Bilirubin	186-195	ATP binding cassette subfamily C member 3	Rattus norvegicus	56-61
11997190-6	2002	We conclude that thyroid hormones and vitamin A are co-regulator of the UGT1 family expression, without affecting the UGT2 family; by modifying activity and expression of the bilirubin UOT isoform, a member of UGT1 family, thyroid hormone reduced the glucuronidation of T4 and rT3.	Bilirubin	175-184	UDP glycosyltransferase 1 family, polypeptide A4, pseudogene	Rattus norvegicus	210-214
12006174-2	2002	HO-1 degrades heme to carbon monoxide (CO), iron, and biliverdin, the latter being reduced to bilirubin by biliverdin reductase.	Bilirubin	94-103	heme oxygenase 1	Rattus norvegicus	0-4
12006180-4	2002	Hypoxia transiently increases the transcriptional rate of the heme oxygenase-1 (HO-1) gene, resulting in increased production of carbon monoxide (CO) and bilirubin.	Bilirubin	154-163	heme oxygenase 1	Homo sapiens	80-84
11927726-0	2002	An early (sixth-hour) serum bilirubin measurement is useful in predicting the development of significant hyperbilirubinemia and severe ABO hemolytic disease in a selective high-risk population of newborns with ABO incompatibility.	Bilirubin	28-37	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	135-138
11909697-2	2002	Several studies have been published on the localization of the carbon monoxide producing enzyme heme oxygenase-2 (HO-2), which concomitantly generates biliverdin; histochemical data on the distribution of biliverdin reductase (BVR), converting biliverdin to bilirubin, are still very scarce in large mammals including humans.	Bilirubin	258-267	biliverdin reductase A	Homo sapiens	205-225
11909697-2	2002	Several studies have been published on the localization of the carbon monoxide producing enzyme heme oxygenase-2 (HO-2), which concomitantly generates biliverdin; histochemical data on the distribution of biliverdin reductase (BVR), converting biliverdin to bilirubin, are still very scarce in large mammals including humans.	Bilirubin	258-267	biliverdin reductase A	Homo sapiens	227-230
11909697-5	2002	Our results substantiate the hypothesis that BVR, through the production of the potent antioxidant bilirubin, might be an essential component of normal physiologic gastrointestinal defense in man and pig.	Bilirubin	99-108	biliverdin reductase A	Homo sapiens	45-48
11915038-0	2002	Hemolysis and bilirubin conjugation in association with UDP-glucuronosyltransferase 1A1 promoter polymorphism.	Bilirubin	14-23	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	56-87
11927726-2	2002	In this study, we aimed to determine prospectively the critical serum total bilirubin level to predict significant hyperbilirubinemia and severe hemolytic disease in healthy term newborns with ABO incompatibility based on a serum bilirubin measurement made at a postnatal age at which all newborns are at the hospital before discharge and at which any therapeutic intervention, if necessary, could be started as early as possible.	Bilirubin	76-85	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	193-196
11927726-16	2002	The 35th and 90th percentile tracks, approximating the serum bilirubin levels of 3.3 mg/dL and 6.5 mg/dL at the sixth hour of life, respectively, can be used as safe risk demarcators in deciding about the time of discharge of ABO-incompatible newborns from the hospital.	Bilirubin	61-70	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	226-229
11773068-1	2002	Human biliverdin reductase (hBVR) is a serine/threonine kinase that catalyzes reduction of the heme oxygenase (HO) activity product, biliverdin, to bilirubin.	Bilirubin	148-157	biliverdin reductase A	Homo sapiens	6-26
11773068-1	2002	Human biliverdin reductase (hBVR) is a serine/threonine kinase that catalyzes reduction of the heme oxygenase (HO) activity product, biliverdin, to bilirubin.	Bilirubin	148-157	biliverdin reductase A	Homo sapiens	28-32
11920537-7	2002	Significant elevation of bilirubin was associated with the dosage of cisplatin used (P = 0.0001), basal bilirubin level (P = 0.0001), basal prothrombin time (P =0.004), basal aspartate aminotransferase (AST) level (P = 0.013), and stage of cirrhosis (P < 0.0001).	Bilirubin	25-34	solute carrier family 17 member 5	Homo sapiens	175-201
11906189-1	2002	The UDP-glucuronosyltransferase UGT1A1 plays a critical role in the detoxification of potentially neurotoxic bilirubin by conjugating it with glucuronic acid.	Bilirubin	109-118	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	32-38
11906189-5	2002	Plasma total bilirubin levels in these double heterozygotes were significantly higher than those in control subjects carrying one or other of these mutations singly, indicating that compound heterozygous mutations may result in more strongly reduced UGT1A1 activity.	Bilirubin	13-22	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	250-256
11893390-1	2002	In our earlier communication on urea denaturation of bovine serum albumin (BSA), we showed significant unfolding of domain III along with domain I prior to intermediate formation around 4.6-5.2 M urea based on the binding results of domain specific ligands:chloroform, bilirubin and diazepam for domains I, II and III, respectively.	Bilirubin	269-278	albumin	Homo sapiens	60-73
11920537-7	2002	Significant elevation of bilirubin was associated with the dosage of cisplatin used (P = 0.0001), basal bilirubin level (P = 0.0001), basal prothrombin time (P =0.004), basal aspartate aminotransferase (AST) level (P = 0.013), and stage of cirrhosis (P < 0.0001).	Bilirubin	25-34	solute carrier family 17 member 5	Homo sapiens	203-206
12048356-3	2002	Interestingly, the increase in the plasma IL-18 concentration was correlated with that in serum bilirubin levels in hepatectomized patients.	Bilirubin	96-105	interleukin 18	Homo sapiens	42-47
12027227-4	2002	Ex-tempore albumin-coating of carbon surface decreases adsorbent capacity by bilirubin on 21%.	Bilirubin	77-86	albumin	Homo sapiens	11-18
11995475-7	2002	Multiple regression analysis showed that serum levels of interleukin-6 and hepatocyte growth factor on day 0 after surgery were significantly correlated with the postoperative maximum total bilirubin level (P < 0.0001).	Bilirubin	190-199	interleukin 6	Homo sapiens	57-70
11995475-7	2002	Multiple regression analysis showed that serum levels of interleukin-6 and hepatocyte growth factor on day 0 after surgery were significantly correlated with the postoperative maximum total bilirubin level (P < 0.0001).	Bilirubin	190-199	hepatocyte growth factor	Homo sapiens	75-99
11995475-8	2002	The maximum interleukin-6 level but not hepatocyte growth factor significantly correlated with the postoperative maximum bilirubin level (P < 0.02).	Bilirubin	121-130	interleukin 6	Homo sapiens	12-25
11829457-1	2002	UDP-glucuronosyltransferase (UGT1A1) is a critical enzyme in the elimination of bilirubin.	Bilirubin	80-89	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	0-27
11829457-1	2002	UDP-glucuronosyltransferase (UGT1A1) is a critical enzyme in the elimination of bilirubin.	Bilirubin	80-89	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	29-35
11992629-7	2002	An antibody raised against CYP2B1 markedly inhibited the PCB-dependent bilirubin degradation and PROD activities of phenobarbital-induced microsomes with similar dose-response curves for the two effects.	Bilirubin	71-80	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	27-33
11992629-7	2002	An antibody raised against CYP2B1 markedly inhibited the PCB-dependent bilirubin degradation and PROD activities of phenobarbital-induced microsomes with similar dose-response curves for the two effects.	Bilirubin	71-80	pyruvate carboxylase	Rattus norvegicus	57-60
11818329-9	2002	These data suggest that the antioxidative action of BIL can attenuate BLM-induced pulmonary fibrosis, partly by inhibiting lung inflammation and production of TGF-beta1.	Bilirubin	52-55	transforming growth factor, beta 1	Rattus norvegicus	159-168
11855932-2	2002	CN-1 is potentially lethal because of the risk of bilirubin encephalopathy (kernicterus).	Bilirubin	50-59	5'-nucleotidase, cytosolic IA	Homo sapiens	0-4
11805006-7	2002	PON1 activity was significantly correlated with serum total proteins, albumin, and bilirubin in patients but not in controls.	Bilirubin	83-92	paraoxonase 1	Homo sapiens	0-4
12119543-1	2002	We evaluated the effects of 7-nitroindazole, a selective neuronal nitric oxide synthetase (nNOS) inhibitor, on bilirubin-induced alterations in brain cell membrane function and energy metabolism in the newborn piglets.	Bilirubin	111-120	nitric oxide synthase 1	Homo sapiens	57-89
11854317-5	2002	CdCl(2)-elicited HO-1 occurred mostly in Leydig cells and coincided with CO generation, as judged by bilirubin-IXalpha immunoreactivity.	Bilirubin	101-110	heme oxygenase 1	Homo sapiens	17-21
12119543-1	2002	We evaluated the effects of 7-nitroindazole, a selective neuronal nitric oxide synthetase (nNOS) inhibitor, on bilirubin-induced alterations in brain cell membrane function and energy metabolism in the newborn piglets.	Bilirubin	111-120	nitric oxide synthase 1	Homo sapiens	91-95
12119543-5	2002	These findings suggest that nitric oxide produced by nNOS is involved in mediating or facilitating bilirubin-induced cerebral dysfunction.	Bilirubin	99-108	nitric oxide synthase 1	Homo sapiens	53-57
12206135-1	2002	The multidrug resistance-associated protein 2 (MRP2) is an ATP-binding cassette transporter involved in biliary, renal, and intestinal secretion of numerous organic anions, including endogenous compounds such as bilirubin and exogenous compounds such as drugs and toxic chemicals.	Bilirubin	212-221	ATP binding cassette subfamily C member 2	Homo sapiens	4-45
12206135-1	2002	The multidrug resistance-associated protein 2 (MRP2) is an ATP-binding cassette transporter involved in biliary, renal, and intestinal secretion of numerous organic anions, including endogenous compounds such as bilirubin and exogenous compounds such as drugs and toxic chemicals.	Bilirubin	212-221	ATP binding cassette subfamily C member 2	Homo sapiens	47-51
12401954-7	2002	Administration of bilirubin entirely prevented HO-1 induction as well as the generation of oxidative stress parameters.	Bilirubin	18-27	heme oxygenase 1	Rattus norvegicus	47-51
12220306-5	2002	Though beneficial effects such as improvement of encephalopathy and renal function as well as reduced bilirubin levels were recorded during MARS therapy, only one patient survived.	Bilirubin	102-111	methionyl-tRNA synthetase 1	Homo sapiens	140-144
11868392-6	2002	UGT1A1 conjugates bilirubin, and mutations of the gene cause hereditary unconjugated hyperbilirubinemias (Crigler-Najjar syndrome and Gilbert"s syndrome).	Bilirubin	18-27	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
12005103-8	2002	The hDAF livers perfused with human blood (Group III) had a lower ALT level, less protein and albumin losses, lower bilirubin levels in the perfusate, less weight gain, and greater bile production than the wild-type livers perfused with human blood.	Bilirubin	116-125	CD55 molecule (Cromer blood group)	Homo sapiens	4-8
11735518-3	2001	Whereas xanthobilirubic acid (which is a model for one-half of bilirubin, the yellow pigment of jaundice) and its homologues with hexanoic and longer acid chains at C-8 engage only in intermolecular hydrogen bonding, 1 is found to engage in intramolecular hydrogen bonding.	Bilirubin	63-72	homeobox C8	Homo sapiens	165-168
12004927-8	2002	The PLA2-II content was significantly higher in bilirubin-positive than in bilirubin-negative gastric juice samples.	Bilirubin	48-57	phospholipase A2 group IIA	Homo sapiens	4-8
12004927-8	2002	The PLA2-II content was significantly higher in bilirubin-positive than in bilirubin-negative gastric juice samples.	Bilirubin	75-84	phospholipase A2 group IIA	Homo sapiens	4-8
11774951-8	2001	The mRNA of MRP3, functioning as an inducible export pump for bilirubin conjugate and bile acid, was expressed not only in the cholestatic liver but also in the liver of control subjects, and the mRNA level was increased in specimens from both the cholestatic liver that had been well drained and from the liver that had been poorly drained.	Bilirubin	62-71	ATP binding cassette subfamily C member 3	Homo sapiens	12-16
11803413-5	2001	Serum-conjugated bilirubin fractions, reflecting intrahepatocytic bilirubin conjugation, were low in G-6-PD-deficient neonates who developed hyperbilirubinemia.	Bilirubin	17-26	glucose-6-phosphate dehydrogenase	Homo sapiens	101-107
11768271-2	2001	The results show that at day 13 of gestational life there is already bilirubin UDP-glucuronosyltransferase gene expression.	Bilirubin	69-78	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	79-106
11714888-9	2001	APAP-UGT activities correlated best with propofol-UGT (r = 0.85; UGT1A9) and bilirubin-UGT (r = 0.66; UGT1A1) activities, but poorly with UGT1A6 protein (r = 0.30).	Bilirubin	77-86	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	5-8
11803413-5	2001	Serum-conjugated bilirubin fractions, reflecting intrahepatocytic bilirubin conjugation, were low in G-6-PD-deficient neonates who developed hyperbilirubinemia.	Bilirubin	66-75	glucose-6-phosphate dehydrogenase	Homo sapiens	101-107
11803413-6	2001	This conjugated bilirubin profile was similar to that seen in adults with Gilbert"s Syndrome, a condition associated with promoter polymorphism for the gene encoding the bilirubin-conjugating enzyme, UGT glucuronosyltransferase 1A1 (UGT).	Bilirubin	16-25	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	200-203
11803413-6	2001	This conjugated bilirubin profile was similar to that seen in adults with Gilbert"s Syndrome, a condition associated with promoter polymorphism for the gene encoding the bilirubin-conjugating enzyme, UGT glucuronosyltransferase 1A1 (UGT).	Bilirubin	16-25	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	233-236
11803413-6	2001	This conjugated bilirubin profile was similar to that seen in adults with Gilbert"s Syndrome, a condition associated with promoter polymorphism for the gene encoding the bilirubin-conjugating enzyme, UGT glucuronosyltransferase 1A1 (UGT).	Bilirubin	170-179	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	233-236
11803431-3	2001	Because the liver architecture is not disturbed in CN-1 and partial correction of bilirubin-UDP-glucuronosyltransferase (UGT1A1) activity is expected to be sufficient for protection against kernicterus, cell and gene therapies are being developed using the Gunn rat as an animal model of the disease.	Bilirubin	82-91	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	121-127
11855737-4	2001	Neuraminidase treatment of the membranes also led to a slight increase in bilirubin binding as compared to untreated membranes.	Bilirubin	74-83	neuraminidase 1	Homo sapiens	0-13
11855737-0	2001	Bilirubin binding to normal and modified human erythrocyte membranes: effect of phospholipases, neuraminidase, trypsin and CaCl2.	Bilirubin	0-9	neuraminidase 1	Homo sapiens	96-109
11546782-0	2001	Homodimerization of human bilirubin-uridine-diphosphoglucuronate glucuronosyltransferase-1 (UGT1A1) and its functional implications.	Bilirubin	26-35	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	92-98
11546782-1	2001	Genetic lesions of bilirubin-uridine-diphosphoglucuronate glucuronosyltransferase-1 (UGT1A1) completely or partially abolish hepatic bilirubin glucuronidation, causing Crigler-Najjar syndrome type 1 or 2, respectively.	Bilirubin	19-28	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	85-91
11668058-1	2001	Heme oxygenase-1 (HO-1) catalyzes the enzymatic degradation of heme to carbon monoxide, bilirubin, and iron.	Bilirubin	88-97	heme oxygenase 1	Homo sapiens	0-16
11668058-1	2001	Heme oxygenase-1 (HO-1) catalyzes the enzymatic degradation of heme to carbon monoxide, bilirubin, and iron.	Bilirubin	88-97	heme oxygenase 1	Homo sapiens	18-22
11668058-3	2001	Here, we investigated the effect of severe hypoxia and reoxygenation on HO-1 expression in cardiomyocytes and determined whether HO-1 and its product, bilirubin, have a protective role against reoxygenation damage.	Bilirubin	151-160	heme oxygenase 1	Homo sapiens	129-133
11668058-9	2001	These results indicate that the HO-1-bilirubin pathway can effectively defend hypoxic cardiomyocytes against reoxygenation injury and highlight the issue of heme availability in the cytoprotective action afforded by HO-1.	Bilirubin	37-46	heme oxygenase 1	Homo sapiens	32-36
11668058-9	2001	These results indicate that the HO-1-bilirubin pathway can effectively defend hypoxic cardiomyocytes against reoxygenation injury and highlight the issue of heme availability in the cytoprotective action afforded by HO-1.	Bilirubin	37-46	heme oxygenase 1	Homo sapiens	216-220
11685683-7	2001	ET-1 correlated with Child"s score, serum total bilirubin, direct bilirubin, aspartate aminotransferase, albumin, prothrombin time, hepaplastin test, fibrinogen, cholinesterase, total cholesterol, Fischer"s molar ratio, prealubumin, and hyaluronic acid, respectively (P <.05).	Bilirubin	48-57	endothelin 1	Homo sapiens	0-4
11685683-7	2001	ET-1 correlated with Child"s score, serum total bilirubin, direct bilirubin, aspartate aminotransferase, albumin, prothrombin time, hepaplastin test, fibrinogen, cholinesterase, total cholesterol, Fischer"s molar ratio, prealubumin, and hyaluronic acid, respectively (P <.05).	Bilirubin	66-75	endothelin 1	Homo sapiens	0-4
11602247-0	2001	Biliary excretion of a stretched bilirubin in UGT1A1-deficient (Gunn) and Mrp2-deficient (TR-) rats.	Bilirubin	33-42	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	46-52
11694308-0	2001	Synthesis and characterization of a biospecific adsorbent containing bovine serum albumin as a ligand and its use for bilirubin retention.	Bilirubin	118-127	albumin	Homo sapiens	76-89
11696670-6	2001	Multiple regression analyses revealed that only alcohol intake and total bilirubin were associated independently with non-transferrin-bound iron values.	Bilirubin	73-82	transferrin	Homo sapiens	122-133
11483603-1	2001	OATP-C (SLC21A6) is the predominant Na(+)-independent uptake system for bile salts and bilirubin of human liver and is expressed exclusively at the basolateral (sinusoidal) hepatocyte membrane.	Bilirubin	87-96	solute carrier organic anion transporter family member 1B1	Homo sapiens	0-6
11483603-1	2001	OATP-C (SLC21A6) is the predominant Na(+)-independent uptake system for bile salts and bilirubin of human liver and is expressed exclusively at the basolateral (sinusoidal) hepatocyte membrane.	Bilirubin	87-96	solute carrier organic anion transporter family member 1B1	Homo sapiens	8-15
11593363-1	2001	Heme oxygenase-1 (HO-1) is an inducible heat shock protein that regulates heme metabolism to form bilirubin, ferritin and carbon monoxide.	Bilirubin	98-107	heme oxygenase 1	Mus musculus	0-16
11593363-1	2001	Heme oxygenase-1 (HO-1) is an inducible heat shock protein that regulates heme metabolism to form bilirubin, ferritin and carbon monoxide.	Bilirubin	98-107	heme oxygenase 1	Mus musculus	18-22
11568288-2	2001	Because casein hydrolysate has been shown to contain a beta-glucuronidase inhibitor, one possible mechanism to explain this finding is blockage of the enterohepatic circulation of bilirubin by a component of the formula.	Bilirubin	180-189	glucuronidase beta	Homo sapiens	55-73
11695848-14	2001	The activity of SN-38 glucuronidation by liver microsomes and UGT1A1 was effectively inhibited by bilirubin.	Bilirubin	98-107	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	62-68
11878580-7	2001	Children with the 7/7 UGT1A genotype had a significantly higher mean bilirubin level (5.8 +/- 3.1 mg/dL) than those with the 6/6 (2.4 +/- 0.8 mg/dL) or 6/7 genotype (3.0 +/- 1.1 mg/dL; P < 0.001 by analysis of variance).	Bilirubin	69-78	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	22-27
11878580-9	2001	CONCLUSIONS: Genetic variation in the UGT1A promoter significantly influences serum bilirubin levels and the development of symptomatic cholelithiasis in children with SCA.	Bilirubin	84-93	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	38-43
11572959-7	2001	Macrophage-inducible NOS generates NO to kill other cells, whereas HO1 generates bilirubin to exert antioxidant cytoprotective effects and also provides cytoprotection by facilitating iron extrusion from cells.	Bilirubin	81-90	heme oxygenase 1	Homo sapiens	67-70
11765160-7	2001	Apo A-I was inversely correlated with Malatack score, Child-Pugh score, total bilirubin, conjugated bilirubin, and prothrombin time (p < .01, p < .01, p < .01, p < .01, p < .05, respectively).	Bilirubin	78-87	apolipoprotein A1	Homo sapiens	0-7
11765160-7	2001	Apo A-I was inversely correlated with Malatack score, Child-Pugh score, total bilirubin, conjugated bilirubin, and prothrombin time (p < .01, p < .01, p < .01, p < .01, p < .05, respectively).	Bilirubin	100-109	apolipoprotein A1	Homo sapiens	0-7
11572959-11	2001	On the other hand, massive neuronal firing during a stroke presumably activates HO2, leading to neuroprotective actions of bilirubin.	Bilirubin	123-132	heme oxygenase 2	Homo sapiens	80-83
11522976-1	2001	BACKGROUND: Bacterial beta-glucuronidase causes deconjugation of bilirubin diglucuronide resulting in the precipitation of calcium bilirubinate, which contributes to biliary sludge and stone formation.	Bilirubin	65-74	glucuronidase beta	Homo sapiens	22-40
11556815-9	2001	The bilirubin conjugating UGT1A1 was mainly involved in the 3-O-glucuronidation of trans-resveratrol, whereas the phenol conjugating UGT1A6 activity was restricted to cis-resveratrol.	Bilirubin	4-13	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	26-32
11587132-8	2001	We conclude that the Radiometer ABL 735 bilirubin assay is suitable for near-patient assessment of neonatal jaundice using whole blood, thus eliminating the need for sample centrifugation.	Bilirubin	40-49	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	32-35
11522976-1	2001	BACKGROUND: Bacterial beta-glucuronidase causes deconjugation of bilirubin diglucuronide resulting in the precipitation of calcium bilirubinate, which contributes to biliary sludge and stone formation.	Bilirubin	123-143	glucuronidase beta	Homo sapiens	22-40
11702667-4	2001	RESULTS: The levels of GH, GHBP and IGF-I in patients with obstructive jaundice were significantly lower (7.4 micrograms/L +/- 3.6 micrograms/L, 9.1 +/- 2.3 B/T* 100, and 49.8 mg/L +/- 6.6 mg/L respectively) than those in control group(13.9 micrograms/L +/- 5.7 micrograms/L, 13.3 +/- 1.6 B/T* 100, and 61.4 mg/L +/- 6.5 mg/L respectively, P < 0.01) and were correlated closely with the levels of bilirubin, prealbumin and endotoxin (P < 0.01).	Bilirubin	400-409	growth hormone 1	Homo sapiens	23-25
11463724-1	2001	Heme oxygenase (HO)-1 degrades the pro-oxidant heme and generates carbon monoxide and antioxidant bilirubin.	Bilirubin	98-107	heme oxygenase 1	Mus musculus	0-21
11554454-1	2001	Heme oxygenase-2 (HO-2) degrades heme [Fe-protoporphyrin IX (Fe-PP)] to CO and bilirubin.	Bilirubin	79-88	heme oxygenase 2	Homo sapiens	0-16
11554454-1	2001	Heme oxygenase-2 (HO-2) degrades heme [Fe-protoporphyrin IX (Fe-PP)] to CO and bilirubin.	Bilirubin	79-88	heme oxygenase 2	Homo sapiens	18-22
11507361-4	2001	Significant correlations were observed between cystatin C concentrations and total bilirubin levels, albumin levels, platelet levels, type IV collagen levels and hyaluronic acid levels.	Bilirubin	83-92	cystatin C	Homo sapiens	47-57
11435909-3	2001	HO-1 metabolizes heme to the antioxidant bilirubin and carbon monoxide, and represents a powerful endogenous defensive mechanism against free radicals in many diseases.	Bilirubin	41-50	heme oxygenase 1	Homo sapiens	0-4
11429329-7	2001	Norepinephrine requirements could be reduced by 72% within 72 h. During AVP infusion, a significant increase in liver enzymes and total bilirubin concentration and a significant decrease in platelet count occurred.	Bilirubin	136-145	arginine vasopressin	Homo sapiens	72-75
11471872-6	2001	biliverdin, diglucuronosyl bilirubin and monoglucuronosyl bilirubin (C-8 and C-12) showed positive logarithmic correlations with (ZZ)-bilirubin (R2=0.16 or above, P<0.05).	Bilirubin	58-67	homeobox C8	Homo sapiens	69-72
11465558-1	2001	BACKGROUND: Heme oxygenase 1 (HO-1), induced by a variety of stressors, provides endogenous carbon monoxide (CO) and bilirubin, both of which play consequential roles in organs.	Bilirubin	117-126	heme oxygenase 1	Rattus norvegicus	12-28
11465558-1	2001	BACKGROUND: Heme oxygenase 1 (HO-1), induced by a variety of stressors, provides endogenous carbon monoxide (CO) and bilirubin, both of which play consequential roles in organs.	Bilirubin	117-126	heme oxygenase 1	Rattus norvegicus	30-34
11471872-6	2001	biliverdin, diglucuronosyl bilirubin and monoglucuronosyl bilirubin (C-8 and C-12) showed positive logarithmic correlations with (ZZ)-bilirubin (R2=0.16 or above, P<0.05).	Bilirubin	58-67	homeobox C8	Homo sapiens	69-72
11408524-3	2001	UGT activity determined in UDP-N-acetylglucosamine-activated microsomes revealed that bilirubin, p-nitrophenol, and ethynylestradiol (17beta-OH and 3-OH) but not androsterone and estrone glucuronidation rates, were decreased in pregnant rats.	Bilirubin	86-95	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	0-3
11425418-2	2001	To determine whether this has a genetic basis we compared the bilirubin levels and frequency of gallstones in patients with different alleles of the UGT*1 gene.	Bilirubin	62-71	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	149-154
11519132-1	2001	We report a human IgG4-lambda type M-protein that reacts with reagents of albumin, direct bilirubin and iron.	Bilirubin	90-99	myomesin 2	Homo sapiens	35-44
11423308-0	2001	Effect of phospholipase C, trypsin and neuraminidase on binding of bilirubin to mammalian erythrocyte membranes.	Bilirubin	67-76	neuraminidase 1	Homo sapiens	39-52
11423308-1	2001	Binding of bilirubin to erythrocyte membranes of human, buffalo, sheep and goat was studied after phospholipase C, trypsin and neuraminidase treatment.	Bilirubin	11-20	neuraminidase 1	Homo sapiens	127-140
11423308-2	2001	Phospholipase C and trypsin treatment of membranes greatly enhanced the bilirubin binding in all mammalian species, whereas, neuraminidase treatment resulted into a small increase in the membrane-bound bilirubin.	Bilirubin	202-211	neuraminidase 1	Homo sapiens	125-138
11423308-4	2001	The order of bilirubin binding to unmodified as well as neuraminidase-treated erythrocyte membranes was: human>sheep>buffalo>goat; the order was: human>buffalo>sheep>goat; in phospholipase C- and trypsin-treated erythrocyte membranes.	Bilirubin	13-22	neuraminidase 1	Homo sapiens	56-69
11436564-11	2001	The total and direct reacting bilirubin concentrations depended on the erythrocytic-enzyme phenotypes (ACP1, PGM1, and GLO1) in both TC and control groups.	Bilirubin	30-39	acid phosphatase 1	Homo sapiens	103-107
11436987-0	2001	Role of heme oxygenase-1 and Kupffer cells in the production of bilirubin in the rat liver.	Bilirubin	64-73	heme oxygenase 1	Rattus norvegicus	8-24
11436987-1	2001	Heme oxygenase (HO)-1, the heme-degrading enzyme in macrophages, plays a key role in bilirubin metabolism.	Bilirubin	85-94	heme oxygenase 1	Rattus norvegicus	0-21
11436564-11	2001	The total and direct reacting bilirubin concentrations depended on the erythrocytic-enzyme phenotypes (ACP1, PGM1, and GLO1) in both TC and control groups.	Bilirubin	30-39	glyoxalase I	Homo sapiens	119-123
11436564-11	2001	The total and direct reacting bilirubin concentrations depended on the erythrocytic-enzyme phenotypes (ACP1, PGM1, and GLO1) in both TC and control groups.	Bilirubin	30-39	phosphoglucomutase 1	Homo sapiens	109-113
11343253-1	2001	The UDP-glucuronosyltransferase, UGT1A1, is the critical enzyme responsible for detoxification of the potentially neurotoxic bilirubin by conjugating it with glucuronic acid.	Bilirubin	125-134	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	33-39
11274970-0	2001	Role of cytochrome P450 1A2 in bilirubin degradation Studies in Cyp1a2 (-/-) mutant mice.	Bilirubin	31-40	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	64-70
11343231-4	2001	The anti-UGT-positive sera from AIH type 2 patients revealed the strongest immunoreactivity against UGT1A1, the main UGT-isoform involved in the bilirubin glucuronidation.	Bilirubin	145-154	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	9-12
11343231-4	2001	The anti-UGT-positive sera from AIH type 2 patients revealed the strongest immunoreactivity against UGT1A1, the main UGT-isoform involved in the bilirubin glucuronidation.	Bilirubin	145-154	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	100-106
11343231-4	2001	The anti-UGT-positive sera from AIH type 2 patients revealed the strongest immunoreactivity against UGT1A1, the main UGT-isoform involved in the bilirubin glucuronidation.	Bilirubin	145-154	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	100-103
11278740-0	2001	Human biliverdin reductase is autophosphorylated, and phosphorylation is required for bilirubin formation.	Bilirubin	86-95	biliverdin reductase A	Homo sapiens	6-26
11278740-1	2001	Biliverdin reductase (BVR) reduces heme oxygenase (HO) activity product, biliverdin, to bilirubin.	Bilirubin	88-97	biliverdin reductase A	Homo sapiens	0-20
11278740-1	2001	Biliverdin reductase (BVR) reduces heme oxygenase (HO) activity product, biliverdin, to bilirubin.	Bilirubin	88-97	biliverdin reductase A	Homo sapiens	22-25
11274970-9	2001	We conclude that CYP1A2 is responsible for microsomal bilirubin degradation in the absence of TCB.	Bilirubin	54-63	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	17-23
11274970-10	2001	TCB was required for bilirubin degradation by CYP1A1.	Bilirubin	21-30	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	46-52
11274970-11	2001	Manipulation of CYP1A2 may be of therapeutic benefit in patients with these diseases of bilirubin conjugation.	Bilirubin	88-97	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	16-22
11780451-0	2001	The preparation of rat heme oxygenase-1 mutant to reduce the level of bilirubin.	Bilirubin	70-79	heme oxygenase 1	Rattus norvegicus	23-39
11259324-5	2001	Chemical inhibition experiments further prove the involvement of UGT1A1 and UGT1A9 in the formation of M1 and M2, as the UGT1A1 substrate bilirubin preferably inhibited M1 over M2 (K(i): 36 and 258 microM, respectively), whereas the UGT1A9 substrate propofol showed a more pronounced decrease in M2 but not in M1 formation (K(i): 47 and 142 microM, respectively).	Bilirubin	138-147	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	65-71
11259324-5	2001	Chemical inhibition experiments further prove the involvement of UGT1A1 and UGT1A9 in the formation of M1 and M2, as the UGT1A1 substrate bilirubin preferably inhibited M1 over M2 (K(i): 36 and 258 microM, respectively), whereas the UGT1A9 substrate propofol showed a more pronounced decrease in M2 but not in M1 formation (K(i): 47 and 142 microM, respectively).	Bilirubin	138-147	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	76-82
11259324-5	2001	Chemical inhibition experiments further prove the involvement of UGT1A1 and UGT1A9 in the formation of M1 and M2, as the UGT1A1 substrate bilirubin preferably inhibited M1 over M2 (K(i): 36 and 258 microM, respectively), whereas the UGT1A9 substrate propofol showed a more pronounced decrease in M2 but not in M1 formation (K(i): 47 and 142 microM, respectively).	Bilirubin	138-147	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	121-127
11259324-5	2001	Chemical inhibition experiments further prove the involvement of UGT1A1 and UGT1A9 in the formation of M1 and M2, as the UGT1A1 substrate bilirubin preferably inhibited M1 over M2 (K(i): 36 and 258 microM, respectively), whereas the UGT1A9 substrate propofol showed a more pronounced decrease in M2 but not in M1 formation (K(i): 47 and 142 microM, respectively).	Bilirubin	138-147	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	233-239
11259359-7	2001	SN-38, the active metabolite of irinotecan, is glucuronidated to the inactive SN-38 glucuronide by UGT1A1, the isoform catalyzing bilirubin glucuronidation.	Bilirubin	130-139	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	99-105
11330432-13	2001	In conclusion these findings indicate that c-fos mRNA expression 15 mins after PHx correlates with hepatic regenerative activity but not the strength of the regenerative stimulus and that hepatic parenchymal loss of 55-70% must occur prior to the detection of elevated serum bilirubin levels.	Bilirubin	275-284	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	43-48
11134001-0	2001	Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6.	Bilirubin	18-27	solute carrier organic anion transporter family member 1B1	Homo sapiens	86-93
11309322-11	2001	Serum bilirubin levels were significantly higher (P = 0.017) and platelets lower (P = 0.03) in TNF-treated compared with non-TNF-treated patients.	Bilirubin	6-15	tumor necrosis factor	Homo sapiens	95-98
11309322-13	2001	CONCLUSIONS: Addition of TNF to melphalan during IHP results in significant differences in post-IHP production of IL-6 and IL-8 with associated changes in mean arterial blood pressure and greater regional toxicity, as reflected in higher levels of serum bilirubin.	Bilirubin	254-263	tumor necrosis factor	Homo sapiens	25-28
11134001-8	2001	Human OATP2 may play a key role in the prevention of hyperbilirubinemia by facilitating the selective entry of unconjugated bilirubin and its glucuronate conjugates into human hepatocytes.	Bilirubin	58-67	solute carrier organic anion transporter family member 1B1	Homo sapiens	6-11
11247059-0	2001	Increase in bilirubin levels of patients with obstructive sleep apnea in the morning--a possible explanation of induced heme oxygenase-1.	Bilirubin	12-21	heme oxygenase 1	Homo sapiens	120-136
11247059-1	2001	STUDY OBJECTIVES: In the absence of heme oxygenase-1 (HO-1), which catalyzes the oxidation of heme to generate carbon monoxide and indirect bilirubin, hypoxia induces severe right ventricular dilation and infarction.	Bilirubin	140-149	heme oxygenase 1	Homo sapiens	36-52
11247059-12	2001	CONCLUSIONS: The increase in bilirubin level by HO-1 might protect OSAHS patients from disorders related to hypoxemia.	Bilirubin	29-38	heme oxygenase 1	Homo sapiens	48-52
11247059-1	2001	STUDY OBJECTIVES: In the absence of heme oxygenase-1 (HO-1), which catalyzes the oxidation of heme to generate carbon monoxide and indirect bilirubin, hypoxia induces severe right ventricular dilation and infarction.	Bilirubin	140-149	heme oxygenase 1	Homo sapiens	54-58
11299074-2	2001	They are responsible for glucuronidation of many substrates, especially including bilirubin (UGT1A1) and phenolic compounds (UGT1A6).	Bilirubin	82-91	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	93-99
11170717-2	2001	The neurotoxic heme is usually detoxified by the constitutive heme oxygenase-2 (HO-2) and its inducible isoform HO-1(heat shock protein 32) resulting in the formation of biliverdin which becomes reduced to bilirubin, carbon monoxide (CO), and iron.	Bilirubin	206-215	heme oxygenase 2	Rattus norvegicus	62-78
11170717-2	2001	The neurotoxic heme is usually detoxified by the constitutive heme oxygenase-2 (HO-2) and its inducible isoform HO-1(heat shock protein 32) resulting in the formation of biliverdin which becomes reduced to bilirubin, carbon monoxide (CO), and iron.	Bilirubin	206-215	heme oxygenase 2	Rattus norvegicus	80-84
11170717-2	2001	The neurotoxic heme is usually detoxified by the constitutive heme oxygenase-2 (HO-2) and its inducible isoform HO-1(heat shock protein 32) resulting in the formation of biliverdin which becomes reduced to bilirubin, carbon monoxide (CO), and iron.	Bilirubin	206-215	heme oxygenase 1	Rattus norvegicus	112-116
11224564-0	2001	Structure of human biliverdin IXbeta reductase, an early fetal bilirubin IXbeta producing enzyme.	Bilirubin	63-72	biliverdin reductase B	Homo sapiens	19-46
11230743-0	2001	Hepatic uptake of organic anions affects the plasma bilirubin level in subjects with Gilbert"s syndrome mutations in UGT1A1.	Bilirubin	52-61	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	117-123
11230743-1	2001	Although in Gilbert"s syndrome (GS), bilirubin glucuronidation is impaired due to an extra TA in the TATA box of the promoter of the gene for bilirubin UDP-glucuronosyltransferase 1 (UGT1A1), many GS homozygotes lack unconjugated hyperbilirubinemia.	Bilirubin	37-46	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	183-189
11230743-8	2001	Within each GS subgroup with defined UGT1A1 mutations, the plasma bilirubin level is in part determined by the organic anion uptake rate, assessed by early plasma disappearance of low-dose BSP.	Bilirubin	66-75	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	37-43
11224565-1	2001	Biliverdin reductase (BVR) is a soluble cytoplasmic enzyme that catalyzes the conversion of biliverdin to bilirubin using NADH or NADPH as electron donor.	Bilirubin	106-115	biliverdin reductase A	Homo sapiens	0-20
11224565-1	2001	Biliverdin reductase (BVR) is a soluble cytoplasmic enzyme that catalyzes the conversion of biliverdin to bilirubin using NADH or NADPH as electron donor.	Bilirubin	106-115	biliverdin reductase A	Homo sapiens	22-25
11642031-2	2001	In the cases of treatment in the patients suffering from hyperferremia the decrease in transferrin iron concentration in the whole blood and plasma occurs correlating with the enhancement of iron excretion from urine and decline of bilirubin level in serum.	Bilirubin	232-241	transferrin	Homo sapiens	87-98
11256798-6	2001	Alanine aminotransferase levels were significantly higher (p=0.05) in patients with bile duct stones than in those without, but also alkaline phosphatase (p=0.07), gamma-glutamyl transferase (p=0.09) and bilirubin (p=0.09) levels seemed to be higher in patients with bile duct stones than in those without, although the differences in these values did not reach statistical significance.	Bilirubin	204-213	glutamic--pyruvic transaminase	Homo sapiens	0-24
11164735-2	2001	Monoglucuronosyl bilirubin is an endogenous substrate for the multidrug resistance protein 2, which is located in rat hepatocyte canalicular membrane.	Bilirubin	17-26	ATP binding cassette subfamily B member 4	Rattus norvegicus	62-92
12889520-2	2001	The IL-18 levels were also significantly correlated with the serum tumor necrosis factor alpha (TNF-alpha) and bilirubin levels.	Bilirubin	111-120	interleukin 18	Homo sapiens	4-9
12211782-3	2001	Although originally developed in patients undergoing the transjugular intrahepatic portosystemic shunt (TIPS) procedure, analysis of OPTN data shows that the components of MELD (in particular, bilirubin) have a very strong correlation with mortality in liver transplant candidates.	Bilirubin	193-202	optineurin	Homo sapiens	133-137
11196269-2	2001	We analyzed the association of chemotherapy-induced hyperbilirubinemia with mutations of the bilirubin uridine-5"-diphosphate (UDP)-glucuronosyltransferase gene (UGT1A1) from two leukemic patients in whom chemotherapy resulted in a hyperbilirubinemic response.	Bilirubin	57-66	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	162-168
11246506-3	2000	These differences in the amount of bound bilirubin to different membrane vesicles were correlated well with the percentage accessibility of sialic acid to neuraminidase in these membranes suggesting that bilirubin bound preferentially to the outer layer of erythrocyte membranes than the inner layer.	Bilirubin	204-213	neuraminidase 1	Homo sapiens	155-168
11113055-1	2000	BACKGROUND: Heme oxygenase (HO)-1 is an enzyme that degrades heme to generate CO (a vasodilatory gas), iron, and the potent antioxidant bilirubin.	Bilirubin	136-145	heme oxygenase 1	Mus musculus	12-33
11117235-15	2000	The AST, ALT, bilirubin and gamma-GGT levels were elevated in CCl4-treated rabbits.	Bilirubin	14-23	C-C motif chemokine 4	Oryctolagus cuniculus	62-66
11258550-1	2000	Heme oxygenase (HO)-1, the rate-limiting enzyme in heme degradation, is induced by oxidative stress and its major end product, bilirubin, is a potent physiological antioxidant.	Bilirubin	127-136	heme oxygenase 1	Rattus norvegicus	0-21
11258576-10	2000	The total area of bilirubin absorbance above 0.14 (abs x min) was 7.8 +/- 2.2 in patients without esophagitis, and 11.7 +/- 4.4 and 17.0 +/- 4.2 in the E1-2 and E3-4 groups, respectively (E3-4 vs no esophagitis, P < 0.05).	Bilirubin	18-27	small nucleolar RNA, H/ACA box 73A	Homo sapiens	152-156
11091279-8	2000	Moreover, serum IL-18 levels in primary biliary cirrhosis were correlated with serum bilirubin concentrations and the Risk scores of the Mayo Clinic prognostic model for the disease.	Bilirubin	85-94	interleukin 18	Homo sapiens	16-21
11201174-1	2000	UDP-glucuronosyltransferases (UGTs) involved in troglitazone glucuronidation in rats and humans have been characterized to support the previous toxicity study on troglitazone in Gunn rats and to examine whether the UGT polymorphism or inhibition of bilirubin metabolism is related to the clinically reported rare cases of liver failure.	Bilirubin	249-258	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	30-33
11201174-5	2000	The multiplicity of UGTs involved in troglitazone glucuronidation in humans may allow even patients lacking bilirubin UGT (UGT1A1) activity to produce troglitazone glucuronide.	Bilirubin	108-117	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	20-23
11201174-5	2000	The multiplicity of UGTs involved in troglitazone glucuronidation in humans may allow even patients lacking bilirubin UGT (UGT1A1) activity to produce troglitazone glucuronide.	Bilirubin	108-117	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	123-129
11170257-0	2000	Bilirubin UDP-glucuronosyltransferase 1A1 gene polymorphisms: susceptibility to oxidative damage and cancer?	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	10-41
11170257-1	2000	The UDP-glucuronosyltransferase 1A1 (UGT1A1) gene product catalyzes the glucuronidation of serum bilirubin as part of normal heme catabolism.	Bilirubin	97-106	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	4-35
11170257-1	2000	The UDP-glucuronosyltransferase 1A1 (UGT1A1) gene product catalyzes the glucuronidation of serum bilirubin as part of normal heme catabolism.	Bilirubin	97-106	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	37-43
11170257-5	2000	We hypothesize that the UGT1A1 TA repeats or other functional polymorphisms resulting in lower serum bilirubin levels may be predictive of genetic susceptibility to oxidative damage and cancer.	Bilirubin	101-110	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	24-30
11061796-3	2000	During our study of defects of the bilirubin uridine diphosphate-glucuronosyltransferase gene (UGT1A1) in patients with hereditary unconjugated hyperbilirubinemia (Crigler-Najjar syndrome and Gilbert"s syndrome) and neonatal hyperbilirubinemia, we encountered a prolonged case associated with breastfeeding; after cessation of breastfeeding, the infant"s bilirubin level became normal.	Bilirubin	35-44	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	95-101
11118808-3	2000	Superoxide is controlled by enzymes such as manganese- or copper-zinc-dependent superoxide dismutase (Mn-SOD, CuZn-SOD), glutathione peroxidase (GPx) and antioxidants derived from heme oxygenase (HO) activity such as biliverdin and bilirubin.	Bilirubin	232-241	superoxide dismutase 2	Rattus norvegicus	102-108
11013440-0	2000	Genetic lesions of bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (UGT1A1) causing Crigler-Najjar and Gilbert syndromes: correlation of genotype to phenotype.	Bilirubin	19-28	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	83-89
11144356-2	2000	We report that APP and APLP bind to heme oxygenase (HO), an enzyme whose product, bilirubin, is antioxidant and neuroprotective.	Bilirubin	82-91	amyloid beta (A4) precursor-like protein 1	Mus musculus	23-27
11058760-4	2000	Although apoD can bind cholesterol, progesterone, pregnenolone, bilirubin and arachidonic acid, it is unclear if any, or all of these, represent its physiological ligands.	Bilirubin	64-73	apolipoprotein D	Homo sapiens	9-13
11023668-4	2000	Interestingly, the increase in the plasma IL-18 concentration was correlated with that in serum bilirubin levels in hepatectomized patients.	Bilirubin	96-105	interleukin 18	Homo sapiens	42-47
11003624-1	2000	Recent research has shown that congenital nonhemolytic low grade hyperbilirubinemias in patients with Gilbert"s syndrome (GS) are linked to mutations in the TATA box upstream of the uridine 5"-diphosphoglucose glucuronosyltransferase (UGT1A1) gene leading to an impaired bilirubin glucuronidation.	Bilirubin	70-79	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	235-241
11013440-2	2000	Bilirubin-UGT(1) (UGT1A1) is the only isoform that significantly contributes to the conjugation of bilirubin.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	10-13
11013440-2	2000	Bilirubin-UGT(1) (UGT1A1) is the only isoform that significantly contributes to the conjugation of bilirubin.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	18-24
11013440-2	2000	Bilirubin-UGT(1) (UGT1A1) is the only isoform that significantly contributes to the conjugation of bilirubin.	Bilirubin	99-108	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	10-13
11013440-2	2000	Bilirubin-UGT(1) (UGT1A1) is the only isoform that significantly contributes to the conjugation of bilirubin.	Bilirubin	99-108	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	18-24
11013440-3	2000	Lesions in the gene encoding bilirubin-UGT(1), lead to complete or partial inactivation of the enzyme causing the rare autosomal recessively inherited conditions, Crigler-Najjar syndrome type-1 (CN-1) and type 2 (CN-2), respectively.	Bilirubin	29-38	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	39-42
11013440-3	2000	Lesions in the gene encoding bilirubin-UGT(1), lead to complete or partial inactivation of the enzyme causing the rare autosomal recessively inherited conditions, Crigler-Najjar syndrome type-1 (CN-1) and type 2 (CN-2), respectively.	Bilirubin	29-38	5'-nucleotidase, cytosolic IA	Homo sapiens	195-211
11013440-3	2000	Lesions in the gene encoding bilirubin-UGT(1), lead to complete or partial inactivation of the enzyme causing the rare autosomal recessively inherited conditions, Crigler-Najjar syndrome type-1 (CN-1) and type 2 (CN-2), respectively.	Bilirubin	29-38	carnosine dipeptidase 2	Homo sapiens	213-217
11013440-5	2000	Severe hyperbilirubinemia seen in CN-1 can cause bilirubin encephalopathy (kernicterus).	Bilirubin	12-21	5'-nucleotidase, cytosolic IA	Homo sapiens	34-38
11013440-11	2000	Several structural mutations of UGT1A1, for example, a G71R substitution, have been reported to cause mild reduction of UGT activity toward bilirubin, resulting in mild hyperbilirubinemia, consistent with Gilbert syndrome.	Bilirubin	140-149	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	32-38
11013440-11	2000	Several structural mutations of UGT1A1, for example, a G71R substitution, have been reported to cause mild reduction of UGT activity toward bilirubin, resulting in mild hyperbilirubinemia, consistent with Gilbert syndrome.	Bilirubin	140-149	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	32-35
10957639-1	2000	Biliverdin reductase (BVR) catalyzes the final step of haem degradation and converts biliverdin to bilirubin using NAD(P)H as an electron donor.	Bilirubin	99-108	biliverdin reductase A	Homo sapiens	0-20
24394454-7	2000	Apolipoprotein A1 and bilirubin were positively associated with Lp(a) in the 40-60 age group and a positive relationship between weight and Lp(a) concentrations was observed in those aged 60 years or over.	Bilirubin	22-31	lipoprotein(a)	Homo sapiens	64-69
10957639-1	2000	Biliverdin reductase (BVR) catalyzes the final step of haem degradation and converts biliverdin to bilirubin using NAD(P)H as an electron donor.	Bilirubin	99-108	biliverdin reductase A	Homo sapiens	22-25
10999728-2	2000	In the liver, SN-38 is glucuronidated (SN-38G) by UGT1A1, which also conjugates bilirubin.	Bilirubin	80-89	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	50-56
11097345-4	2000	Polymorphisms in UGT1A1, the major bilirubin-glucuronidating form, often result in a decreased capacity to glucuronidate bilirubin, such as observed in Gilbert Syndrome and some forms of perinatal jaundice.	Bilirubin	35-44	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	17-23
11097345-4	2000	Polymorphisms in UGT1A1, the major bilirubin-glucuronidating form, often result in a decreased capacity to glucuronidate bilirubin, such as observed in Gilbert Syndrome and some forms of perinatal jaundice.	Bilirubin	121-130	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	17-23
11097345-9	2000	However, unless the UGT in question is responsible for the exclusive metabolism of a particular drug or chemical (e.g. UGT1A1 and bilirubin) or is the predominant or only UGT present in the cell, it is unlikely that these polymorphisms will be of major clinical significance.	Bilirubin	130-139	beta-1,3-glucuronyltransferase 2	Homo sapiens	20-23
11084378-13	2000	Administration of bilirubin (5 micromol kg(-1) body weight) or S-adenosyl L-methionine (46 micromol kg(-1) body weight) 2 h before APAP treatment entirely prevented the increase in malondialdehyde (MDA) content, the decrease in GSH levels as well as HO and ALA-S induction.	Bilirubin	18-27	5'-aminolevulinate synthase 1	Rattus norvegicus	257-262
11100318-3	2000	Phospholipase A2 activity in serum from healthy subjects was also measured after incubation with 5-30 mg of bilirubin per dL or 0.1-5 mM of cholic acid for 60 min at 37 degrees C. RESULTS: Serum phospholipase A2 activity was significantly lower in patients with hyperbilirubinemia.	Bilirubin	108-117	phospholipase A2 group IB	Homo sapiens	0-16
11100318-4	2000	There were negative correlations between serum phospholipase A2 activity and concentration of total bilirubin (r = 0.668; P < 0.0001) or total bile acids (r = 0.423; P < 0.05) in patients with hyperbilirubinemia.	Bilirubin	100-109	phospholipase A2 group IB	Homo sapiens	47-63
11059940-1	2000	BACKGROUND AND AIMS: The bacterial beta-glucuronidase (bBG) can deconjugate conjugated bilirubin to form calcium bilirubinate gallstone.	Bilirubin	87-96	glucuronidase beta	Homo sapiens	35-53
11059940-1	2000	BACKGROUND AND AIMS: The bacterial beta-glucuronidase (bBG) can deconjugate conjugated bilirubin to form calcium bilirubinate gallstone.	Bilirubin	105-125	glucuronidase beta	Homo sapiens	35-53
11077333-1	2000	Pigment stones are thought to form as a result of deconjugation of bilirubin by bacterial beta-glucuronidase, which results in precipitation of calcium bilirubinate.	Bilirubin	67-76	glucuronidase beta	Homo sapiens	90-108
11077333-1	2000	Pigment stones are thought to form as a result of deconjugation of bilirubin by bacterial beta-glucuronidase, which results in precipitation of calcium bilirubinate.	Bilirubin	144-164	glucuronidase beta	Homo sapiens	90-108
11182932-0	2000	Crigler-Najjar syndrome type II resulting from three different mutations in the bilirubin uridine 5"-diphosphate-glucuronosyltransferase (UGT1A1) gene.	Bilirubin	80-89	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	138-144
10944550-10	2000	MRP2 is the major transporter responsible for the secretion of bilirubin glucuronides into bile, and humans without MRP2 develop a mild liver disease known as the Dubin-Johnson syndrome.	Bilirubin	63-72	ATP binding cassette subfamily C member 2	Homo sapiens	0-4
10944550-10	2000	MRP2 is the major transporter responsible for the secretion of bilirubin glucuronides into bile, and humans without MRP2 develop a mild liver disease known as the Dubin-Johnson syndrome.	Bilirubin	63-72	ATP binding cassette subfamily C member 2	Homo sapiens	116-120
11022826-3	2000	METHODS AND RESULTS: Incubation of hepatocytes with bilirubin (48 micromol/L) for 24 h significantly increased the mRNA expression of UGT1A1 and UGT1A5, two UGT isoforms responsible for the conjugation of bilirubin.	Bilirubin	52-61	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	134-140
10915645-0	2000	Role of apolipoprotein D in the transport of bilirubin in plasma.	Bilirubin	45-54	apolipoprotein D	Homo sapiens	8-24
10915645-2	2000	Because unconjugated bilirubin has been shown to bind apo D with a 0.	Bilirubin	21-30	apolipoprotein D	Homo sapiens	54-59
10915645-6	2000	Affinity of human apo D for bilirubin was determined by steady-state fluorescence quenching, with Scatchard analysis demonstrating a single binding site for unconjugated bilirubin with an affinity constant (K(a)) of approximately 3 x 10(7) M(-1).	Bilirubin	28-37	apolipoprotein D	Homo sapiens	18-23
10915645-6	2000	Affinity of human apo D for bilirubin was determined by steady-state fluorescence quenching, with Scatchard analysis demonstrating a single binding site for unconjugated bilirubin with an affinity constant (K(a)) of approximately 3 x 10(7) M(-1).	Bilirubin	170-179	apolipoprotein D	Homo sapiens	18-23
10915645-8	2000	Using stopped-flow techniques, the first-order rate constant for bilirubin dissociation from apo D was measured at 5.4 s(-1) (half-time = 129 ms).	Bilirubin	65-74	apolipoprotein D	Homo sapiens	93-98
10915645-9	2000	Our findings indicate that HDL is the principal nonalbumin carrier of bilirubin in human plasma and further support the proposition that the affinity of HDL for bilirubin is primarily the result of binding to apo D.	Bilirubin	161-170	apolipoprotein D	Homo sapiens	209-214
10946897-3	2000	The predominant thyroid hormone released from the thyroid gland, T4, and the inactive rT3 are glucuronidated by cloned expressed bilirubin UGT1A1 and also phenol UGT1A9.	Bilirubin	129-138	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	139-145
11022826-3	2000	METHODS AND RESULTS: Incubation of hepatocytes with bilirubin (48 micromol/L) for 24 h significantly increased the mRNA expression of UGT1A1 and UGT1A5, two UGT isoforms responsible for the conjugation of bilirubin.	Bilirubin	52-61	UDP glucuronosyltransferase family 1 member A5	Rattus norvegicus	145-151
11022826-3	2000	METHODS AND RESULTS: Incubation of hepatocytes with bilirubin (48 micromol/L) for 24 h significantly increased the mRNA expression of UGT1A1 and UGT1A5, two UGT isoforms responsible for the conjugation of bilirubin.	Bilirubin	205-214	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	134-140
11022826-4	2000	The induction of UGT1A1 and UGT1A5 by bilirubin was concentration and time dependent.	Bilirubin	38-47	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	17-23
11022826-4	2000	The induction of UGT1A1 and UGT1A5 by bilirubin was concentration and time dependent.	Bilirubin	38-47	UDP glucuronosyltransferase family 1 member A5	Rattus norvegicus	28-34
10975608-1	2000	The activity of uridine-diphosphoglucuronosyl transferase 1 (UGT1) may influence the concentration of serum bilirubin.	Bilirubin	108-117	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	16-59
10975608-1	2000	The activity of uridine-diphosphoglucuronosyl transferase 1 (UGT1) may influence the concentration of serum bilirubin.	Bilirubin	108-117	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	61-65
10975608-6	2000	Subjects with 6/7 or heterozygous variation within the coding region or compound heterozygous (plus one homozygous) variation had significantly higher bilirubin levels than those with wild UGT1A1 gene.	Bilirubin	151-160	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	189-195
10975608-7	2000	When the 290 subjects were stratified into six groups according to their serum bilirubin concentrations, the bilirubin levels were correlated well to the frequencies of variant UGT1A1 gene.	Bilirubin	79-88	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	177-183
10975608-7	2000	When the 290 subjects were stratified into six groups according to their serum bilirubin concentrations, the bilirubin levels were correlated well to the frequencies of variant UGT1A1 gene.	Bilirubin	109-118	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	177-183
10975608-8	2000	Our results show that there is a strong association between UGT1A1 gene and bilirubin levels in healthy Taiwanese adults.	Bilirubin	76-85	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	60-66
11091029-6	2000	The elevation of UGT1A1 mRNA was observed in the liver of ethanol consumer animals with the simultaneous increase in microsomal UGT1A1 protein leading to stimulated bilirubin glucuronidation both in vivo and in microsomal vesicles.	Bilirubin	165-174	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	17-23
11091029-6	2000	The elevation of UGT1A1 mRNA was observed in the liver of ethanol consumer animals with the simultaneous increase in microsomal UGT1A1 protein leading to stimulated bilirubin glucuronidation both in vivo and in microsomal vesicles.	Bilirubin	165-174	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	128-134
11679201-2	2000	High concentrations of BR decreased thiobarbituric acid reactive substances (TBARS) and catalase activities, increased superoxide dismutase (SOD) activity, but had no effect on glutathione (GSH) concentration.	Bilirubin	23-25	superoxide dismutase 1	Homo sapiens	119-139
11679201-2	2000	High concentrations of BR decreased thiobarbituric acid reactive substances (TBARS) and catalase activities, increased superoxide dismutase (SOD) activity, but had no effect on glutathione (GSH) concentration.	Bilirubin	23-25	superoxide dismutase 1	Homo sapiens	141-144
10793074-3	2000	By 12 weeks after BDL, IL-6(-/-) mice develop significantly higher total serum bilirubin levels (23.2 +/- 2.3 versus 14.9 +/- 2.1 mg/dl, P < 0.0001; delta bilirubin subfraction 16.7 +/- 4.0% versus 9.2 +/- 1.8%; P < 0.002), and the majority (15/18) show "black" gallbladder bile, compared to IL-6(+/+) mice (5/16; P < 0.003).	Bilirubin	79-88	interleukin 6	Mus musculus	23-27
10934805-6	2000	Patients with elevated serum GGT had significantly higher serum levels of alanine and aspartate aminotransferases, alkaline phosphatase and total bilirubin, significantly higher histologic scores of liver lobular necro-inflammation and fibrosis when compared to patients with normal serum GGT.	Bilirubin	146-155	inactive glutathione hydrolase 2	Homo sapiens	29-32
10839994-2	2000	In several circumstances, this cytoprotective effect has been attributed to increased generation of the antioxidant bilirubin during haem degradation by HO-1.	Bilirubin	116-125	heme oxygenase 1	Homo sapiens	153-157
10839994-3	2000	However, a direct implication for HO-1-derived bilirubin in protection against oxidative stress remains to be established.	Bilirubin	47-56	heme oxygenase 1	Homo sapiens	34-38
10839994-5	2000	We found that hemin-mediated increase in HO-1 protein expression and haem oxygenase activity is associated with augmented bilirubin levels.	Bilirubin	122-131	heme oxygenase 1	Homo sapiens	41-45
10839994-8	2000	Interestingly, this protective effect was manifest only when cells were actively producing bilirubin as a consequence of increased haem availability and utilization by HO-1.	Bilirubin	91-100	heme oxygenase 1	Homo sapiens	168-172
10839994-11	2000	Our findings provide direct evidence that bilirubin generated after up-regulation of the HO-1 pathway is cytoprotective against oxidative stress.	Bilirubin	42-51	heme oxygenase 1	Homo sapiens	89-93
10897581-7	2000	In two patients receiving TAB total bilirubin levels showed slight, transient elevations after maximum elevations of AST and ALT.	Bilirubin	36-45	solute carrier family 17 member 5	Homo sapiens	117-120
10862526-6	2000	The first (28%, of clones) was most homologous to UGT1A1 (the bilirubin-UGT), while the second (72% of clones) showed homology to several isoforms, but could not be unambiguously identified, and was designated cat UGT1A02.	Bilirubin	62-71	UDP-glucuronosyltransferase 1-1	Felis catus	50-56
10862526-6	2000	The first (28%, of clones) was most homologous to UGT1A1 (the bilirubin-UGT), while the second (72% of clones) showed homology to several isoforms, but could not be unambiguously identified, and was designated cat UGT1A02.	Bilirubin	62-71	UDP-glucuronosyltransferase 1-1	Felis catus	50-53
10775141-9	2000	Biliverdin (or its metabolite, bilirubin), rather than CO, may account for this action of HO-1 on endothelial cell adhesion molecule expression.	Bilirubin	31-40	heme oxygenase 1	Rattus norvegicus	90-94
10807735-6	2000	SIN-1 and 8-bromo-cGMP increased heme oxygenase activity (bilirubin formation).	Bilirubin	58-67	MAPK associated protein 1	Homo sapiens	0-22
10793074-3	2000	By 12 weeks after BDL, IL-6(-/-) mice develop significantly higher total serum bilirubin levels (23.2 +/- 2.3 versus 14.9 +/- 2.1 mg/dl, P < 0.0001; delta bilirubin subfraction 16.7 +/- 4.0% versus 9.2 +/- 1.8%; P < 0.002), and the majority (15/18) show "black" gallbladder bile, compared to IL-6(+/+) mice (5/16; P < 0.003).	Bilirubin	158-167	interleukin 6	Mus musculus	23-27
10793074-7	2000	Daily treatment with exogenous recombinant IL-6 for 3-6 weeks starting at 6 weeks after BDL significantly lowers the serum total bilirubin in both groups.	Bilirubin	129-138	interleukin 6	Mus musculus	43-47
10773020-10	2000	The increase in HO-1 activity after adenovirus-mediated human HO-1 gene transfer may prove useful as a means of selectively increasing enzyme activity in a specific organ and regulating homeostasis by modulation of vasoactive molecules such as carbon monoxide and bilirubin and, in addition, providing a means of delivering the human HO-1 gene for experimental purposes.	Bilirubin	264-273	heme oxygenase 1	Homo sapiens	16-20
10773020-10	2000	The increase in HO-1 activity after adenovirus-mediated human HO-1 gene transfer may prove useful as a means of selectively increasing enzyme activity in a specific organ and regulating homeostasis by modulation of vasoactive molecules such as carbon monoxide and bilirubin and, in addition, providing a means of delivering the human HO-1 gene for experimental purposes.	Bilirubin	264-273	heme oxygenase 1	Homo sapiens	62-66
10773020-10	2000	The increase in HO-1 activity after adenovirus-mediated human HO-1 gene transfer may prove useful as a means of selectively increasing enzyme activity in a specific organ and regulating homeostasis by modulation of vasoactive molecules such as carbon monoxide and bilirubin and, in addition, providing a means of delivering the human HO-1 gene for experimental purposes.	Bilirubin	264-273	heme oxygenase 1	Homo sapiens	62-66
10803780-16	2000	IL-6 was correlated positively with white blood cell and neutrophil counts, C-reactive protein, and serum total bilirubin and negatively with hepaplastin test and serum total protein levels.	Bilirubin	112-121	interleukin 6	Homo sapiens	0-4
10832380-10	2000	Positive correlation was found between the activity of neprilysin and serum bilirubin, alkaline-phosphatase and gamma-glutamyl-transferase (p < 0.005 for each).	Bilirubin	76-85	membrane metalloendopeptidase	Homo sapiens	55-65
10821120-7	2000	When a beta-glucuronidase inhibitor such as saccharic acid 1,4-lactone, glycyrrhizin or 1-naphtyl-beta-D-glucuronide was added to the reaction mixture, the bilirubin conjugation activity of the human UGT1A1 was detected.	Bilirubin	156-165	glucuronidase beta	Homo sapiens	7-25
10821120-7	2000	When a beta-glucuronidase inhibitor such as saccharic acid 1,4-lactone, glycyrrhizin or 1-naphtyl-beta-D-glucuronide was added to the reaction mixture, the bilirubin conjugation activity of the human UGT1A1 was detected.	Bilirubin	156-165	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	200-206
10821120-8	2000	When geniposide was added to the reaction mixture, the bilirubin conjugation activity of UGT1A1 was not seen.	Bilirubin	55-64	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	89-95
10753261-2	2000	We show that the combined effect of an increased bilirubin load caused by dyserythropoiesis in CDA II and decreased bilirubin conjugation caused by reduced expression of uridine diphosphate glucuronosyl transferase (UGT1A) would increase the risk of hyperbilirubinemia (P <.005) and gallstone formation (chi(2): P <.	Bilirubin	49-58	SEC23 homolog B, COPII coat complex component	Homo sapiens	95-101
10753261-2	2000	We show that the combined effect of an increased bilirubin load caused by dyserythropoiesis in CDA II and decreased bilirubin conjugation caused by reduced expression of uridine diphosphate glucuronosyl transferase (UGT1A) would increase the risk of hyperbilirubinemia (P <.005) and gallstone formation (chi(2): P <.	Bilirubin	116-125	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	170-214
10753261-2	2000	We show that the combined effect of an increased bilirubin load caused by dyserythropoiesis in CDA II and decreased bilirubin conjugation caused by reduced expression of uridine diphosphate glucuronosyl transferase (UGT1A) would increase the risk of hyperbilirubinemia (P <.005) and gallstone formation (chi(2): P <.	Bilirubin	116-125	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	216-221
10790694-0	2000	The products of YCF1 and YLL015w (BPT1) cooperate for the ATP-dependent vacuolar transport of unconjugated bilirubin in Saccharomyces cerevisiae.	Bilirubin	107-116	ATP-binding cassette glutathione S-conjugate transporter YCF1	Saccharomyces cerevisiae S288C	16-20
10847479-7	2000	Compared to IL-6+/+ controls, IL-6-/- mice showed slightly less BEC proliferation, a trend toward more liver injury, and significantly higher total serum bilirubin (TB) levels, suggestive of impaired biliary tree integrity.	Bilirubin	154-163	interleukin 6	Mus musculus	30-34
10847479-11	2000	However, the long-term response to BDL results in a distinct phenotype in the IL-6-/- mice, marked by a relentless rise in serum total bilirubin and an inability to maintain compensatory increase in liver mass.	Bilirubin	135-144	interleukin 6	Mus musculus	78-82
10790694-0	2000	The products of YCF1 and YLL015w (BPT1) cooperate for the ATP-dependent vacuolar transport of unconjugated bilirubin in Saccharomyces cerevisiae.	Bilirubin	107-116	ATP-binding cassette bilirubin transporter BPT1	Saccharomyces cerevisiae S288C	34-38
10790694-2	2000	Vacuoles from Saccharomyces cerevisiae showed an ATP-dependent, saturative transport of unconjugated bilirubin (UCB) that was reduced by 60% and 40% in YCF1 and YLL015w-deleted cells, respectively; the double deletant showed no UCB uptake.	Bilirubin	101-110	ATP-binding cassette glutathione S-conjugate transporter YCF1	Saccharomyces cerevisiae S288C	152-156
10790694-5	2000	Since YCF1 and YLL015w are rather homologous with multidrug resistant proteins (MRPs), they also suggest the involvement of this class of transporters in the ATP-dependent transport of unconjugated bilirubin.	Bilirubin	198-207	ATP-binding cassette glutathione S-conjugate transporter YCF1	Saccharomyces cerevisiae S288C	6-10
10712264-5	2000	Moreover, the mRNA level of MRP3, but not that of P-gp, was increased in SD rats after administration of bilirubin and in Gunn rats whose hepatic bilirubin concentration is elevated because of a defect in the expression of UDP-glucuronosyl transferase.	Bilirubin	105-114	ATP binding cassette subfamily C member 3	Rattus norvegicus	28-32
10712264-5	2000	Moreover, the mRNA level of MRP3, but not that of P-gp, was increased in SD rats after administration of bilirubin and in Gunn rats whose hepatic bilirubin concentration is elevated because of a defect in the expression of UDP-glucuronosyl transferase.	Bilirubin	146-155	ATP binding cassette subfamily C member 3	Rattus norvegicus	28-32
10712264-7	2000	Although the increased MRP3 mRNA level was associated with the increased concentration of bilirubin and/or its glucuronides in mutant rats and in SD rats that had undergone common bile duct ligation or alpha-naphthylisothiocyanate treatment, we must assume that factor(s) other than these physiological substances are also involved in the increased protein level of MRP3.	Bilirubin	90-99	ATP binding cassette subfamily C member 3	Rattus norvegicus	23-27
10699105-1	2000	OBJECTIVE: To assess the validity of predischarge serum bilirubin values in determining or predicting hyperbilirubinemia in glucose-6-phosphate dehydrogenase (G-6-PD)-deficient neonates, and to facilitate appropriate discharge planning.	Bilirubin	56-65	glucose-6-phosphate dehydrogenase	Homo sapiens	124-157
10699105-3	2000	Percentile-based bilirubin nomograms were constructed for G-6-PD-deficient infants and normal infants according to age at sampling.	Bilirubin	17-26	glucose-6-phosphate dehydrogenase	Homo sapiens	58-64
10699105-8	2000	CONCLUSIONS: Timed, predischarge serum bilirubin screening can be used to identify G-6-PD-deficient neonates at low, intermediate, or high-risk of developing severe neonatal hyperbilirubinemia, and thus offer a selective approach to the discharge and follow-up surveillance of these infants.	Bilirubin	39-48	glucose-6-phosphate dehydrogenase	Homo sapiens	83-89
10708165-10	2000	The peak concentration of IL-1beta was significantly correlated with the level of bilirubin at admission and the intraoperative blood product requirement.	Bilirubin	82-91	interleukin 1 beta	Homo sapiens	26-34
10885031-0	2000	[Bilirubin as an endogenous intermediary in the activation of CYP1A1 expression upon exposure to ultrasound].	Bilirubin	1-10	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	62-68
10885031-4	2000	In the present study the ability of the endogenous heme metabolite, bilirubin, to regulate CYP1A1 activity was examined.	Bilirubin	68-77	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	91-97
10885031-5	2000	The following parameters were investigated: expression of CYP1A1 in rat liver at a level mRNA, protein and functional activity under at the experimental rising of blood bilirubin level.	Bilirubin	169-178	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	58-64
10885031-8	2000	The rise of bilirubin levels of in rat blood after intravenous administration of bilirubin as well as after ultrasound treatment was accompanied by increased mRNA CYP1A1, protein and functional activity of CYP1A1.	Bilirubin	12-21	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	163-169
10885031-8	2000	The rise of bilirubin levels of in rat blood after intravenous administration of bilirubin as well as after ultrasound treatment was accompanied by increased mRNA CYP1A1, protein and functional activity of CYP1A1.	Bilirubin	12-21	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	206-212
10885031-8	2000	The rise of bilirubin levels of in rat blood after intravenous administration of bilirubin as well as after ultrasound treatment was accompanied by increased mRNA CYP1A1, protein and functional activity of CYP1A1.	Bilirubin	81-90	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	163-169
10885031-8	2000	The rise of bilirubin levels of in rat blood after intravenous administration of bilirubin as well as after ultrasound treatment was accompanied by increased mRNA CYP1A1, protein and functional activity of CYP1A1.	Bilirubin	81-90	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	206-212
10885031-9	2000	The comparison of these data with that of time-dependent changes of parameters of CYP1A1 transcriptional activity under ultrasound action and experimental rising of blood bilirubin level suggest that induces CYP1A1 and may be an intermediate in the activation of CYP1A1 expression under ultrasound action.	Bilirubin	171-180	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	82-88
10885031-9	2000	The comparison of these data with that of time-dependent changes of parameters of CYP1A1 transcriptional activity under ultrasound action and experimental rising of blood bilirubin level suggest that induces CYP1A1 and may be an intermediate in the activation of CYP1A1 expression under ultrasound action.	Bilirubin	171-180	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	208-214
10885031-9	2000	The comparison of these data with that of time-dependent changes of parameters of CYP1A1 transcriptional activity under ultrasound action and experimental rising of blood bilirubin level suggest that induces CYP1A1 and may be an intermediate in the activation of CYP1A1 expression under ultrasound action.	Bilirubin	171-180	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	208-214
10675499-2	2000	To further examine this hypothesis, we studied the uptake of bovine serum albumin (BSA)-bound bilirubin by cultured hepatoblastoma (HepG2) cells.	Bilirubin	94-103	albumin	Homo sapiens	68-81
10675499-5	2000	Consistent with reported solvation rates, the cellular uptake of bilirubin bound to human serum albumin was more rapid than for BSA-bound bilirubin, indicative of dissociation-limited uptake.	Bilirubin	65-74	albumin	Homo sapiens	90-103
10666097-0	2000	Heme oxygenase-1-derived bilirubin ameliorates postischemic myocardial dysfunction.	Bilirubin	25-34	heme oxygenase 1	Rattus norvegicus	0-16
10708165-11	2000	The peak concentration of IL-6 was significantly correlated with the admission bilirubin and the intraoperative blood product requirement.	Bilirubin	79-88	interleukin 6	Homo sapiens	26-30
10708165-12	2000	A multivariate regression model revealed that the serum bilirubin and the intraoperative blood product requirement were the independent factors that influenced the peak concentration of IL-1beta or IL-6.	Bilirubin	56-65	interleukin 1 beta	Homo sapiens	186-194
10708165-12	2000	A multivariate regression model revealed that the serum bilirubin and the intraoperative blood product requirement were the independent factors that influenced the peak concentration of IL-1beta or IL-6.	Bilirubin	56-65	interleukin 6	Homo sapiens	198-202
10644574-9	2000	Our results indicate that OATP2 is important for the uptake of organic anions, including bilirubin conjugates and sulfobromophthalein, in human liver.	Bilirubin	89-98	solute carrier organic anion transporter family member 1B1	Homo sapiens	26-31
10836148-6	2000	In addition, characterization of the UGT1A locus and genetic studies directed at understanding the role of bilirubin glucuronidation and the biochemical basis of the clinical symptoms found in unconjugated hyperbilirubinemia have uncovered the structural gene polymorphisms associated with Crigler-Najjar"s and Gilbert"s syndrome.	Bilirubin	107-116	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	37-42
11023036-2	2000	(1) Mechanism of bilirubin uptake into hepatocytes: many organic anions are incorporated into hepatocytes by organic anion transporting polypeptides (rat, oatp1, oatp2, oatp3; human, OATP), liver-specific transporter (rlst/HLST), and/or by organic anion transporters (OAT2, OAT3).	Bilirubin	17-26	solute carrier organic anion transporter family, member 1a1	Rattus norvegicus	155-160
11023036-2	2000	(1) Mechanism of bilirubin uptake into hepatocytes: many organic anions are incorporated into hepatocytes by organic anion transporting polypeptides (rat, oatp1, oatp2, oatp3; human, OATP), liver-specific transporter (rlst/HLST), and/or by organic anion transporters (OAT2, OAT3).	Bilirubin	17-26	solute carrier organic anion transporter family, member 1A5	Rattus norvegicus	169-174
10719751-6	2000	The plasma hHGF concentrations correlated with white cell count, prothrombin time and bilirubin half-life (P<0.05), but not with the values from other liver function tests.	Bilirubin	86-95	hepatocyte growth factor	Homo sapiens	11-15
11023036-2	2000	(1) Mechanism of bilirubin uptake into hepatocytes: many organic anions are incorporated into hepatocytes by organic anion transporting polypeptides (rat, oatp1, oatp2, oatp3; human, OATP), liver-specific transporter (rlst/HLST), and/or by organic anion transporters (OAT2, OAT3).	Bilirubin	17-26	solute carrier organic anion transporter family member 1A2	Homo sapiens	183-187
11023036-2	2000	(1) Mechanism of bilirubin uptake into hepatocytes: many organic anions are incorporated into hepatocytes by organic anion transporting polypeptides (rat, oatp1, oatp2, oatp3; human, OATP), liver-specific transporter (rlst/HLST), and/or by organic anion transporters (OAT2, OAT3).	Bilirubin	17-26	solute carrier family 22 member 7	Homo sapiens	190-216
11023036-7	2000	In the ER, bilirubin is conjugated by bilirubin uridine diphosphate (UDP)-glycosyltransferase (bilirubin UGT; UGT1A1) to form mono- and diglucuronides of bilirubin.	Bilirubin	38-47	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	105-108
11023036-7	2000	In the ER, bilirubin is conjugated by bilirubin uridine diphosphate (UDP)-glycosyltransferase (bilirubin UGT; UGT1A1) to form mono- and diglucuronides of bilirubin.	Bilirubin	38-47	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	110-116
11023036-2	2000	(1) Mechanism of bilirubin uptake into hepatocytes: many organic anions are incorporated into hepatocytes by organic anion transporting polypeptides (rat, oatp1, oatp2, oatp3; human, OATP), liver-specific transporter (rlst/HLST), and/or by organic anion transporters (OAT2, OAT3).	Bilirubin	17-26	solute carrier family 22 member 7	Homo sapiens	268-272
11023036-8	2000	(3) Transport mechanism of bilirubin glucuronides across the hepatocyte canalicular membrane: at the canalicular membrane, bilirubin glucuronides are excreted into bile by multidrug resistance-associated protein 2 (MRP2), a member of the ATP-binding cassette transporter family.	Bilirubin	27-36	ATP binding cassette subfamily C member 2	Homo sapiens	172-213
11023036-8	2000	(3) Transport mechanism of bilirubin glucuronides across the hepatocyte canalicular membrane: at the canalicular membrane, bilirubin glucuronides are excreted into bile by multidrug resistance-associated protein 2 (MRP2), a member of the ATP-binding cassette transporter family.	Bilirubin	27-36	ATP binding cassette subfamily C member 2	Homo sapiens	215-219
11023036-2	2000	(1) Mechanism of bilirubin uptake into hepatocytes: many organic anions are incorporated into hepatocytes by organic anion transporting polypeptides (rat, oatp1, oatp2, oatp3; human, OATP), liver-specific transporter (rlst/HLST), and/or by organic anion transporters (OAT2, OAT3).	Bilirubin	17-26	solute carrier family 22 member 8	Homo sapiens	274-278
11023036-8	2000	(3) Transport mechanism of bilirubin glucuronides across the hepatocyte canalicular membrane: at the canalicular membrane, bilirubin glucuronides are excreted into bile by multidrug resistance-associated protein 2 (MRP2), a member of the ATP-binding cassette transporter family.	Bilirubin	123-132	ATP binding cassette subfamily C member 2	Homo sapiens	172-213
11023036-8	2000	(3) Transport mechanism of bilirubin glucuronides across the hepatocyte canalicular membrane: at the canalicular membrane, bilirubin glucuronides are excreted into bile by multidrug resistance-associated protein 2 (MRP2), a member of the ATP-binding cassette transporter family.	Bilirubin	123-132	ATP binding cassette subfamily C member 2	Homo sapiens	215-219
11023036-7	2000	In the ER, bilirubin is conjugated by bilirubin uridine diphosphate (UDP)-glycosyltransferase (bilirubin UGT; UGT1A1) to form mono- and diglucuronides of bilirubin.	Bilirubin	11-20	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	105-108
11023036-9	2000	(4) Regurgitation of bilirubin glucuronides into blood: MRP3, which is located in the lateral membrane, transports bilirubin glucuronides into blood under conditions of impaired biliary bilirubin excretion.	Bilirubin	21-30	ATP binding cassette subfamily C member 3	Homo sapiens	56-60
11023036-7	2000	In the ER, bilirubin is conjugated by bilirubin uridine diphosphate (UDP)-glycosyltransferase (bilirubin UGT; UGT1A1) to form mono- and diglucuronides of bilirubin.	Bilirubin	11-20	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	110-116
11023036-9	2000	(4) Regurgitation of bilirubin glucuronides into blood: MRP3, which is located in the lateral membrane, transports bilirubin glucuronides into blood under conditions of impaired biliary bilirubin excretion.	Bilirubin	115-124	ATP binding cassette subfamily C member 3	Homo sapiens	56-60
11023036-7	2000	In the ER, bilirubin is conjugated by bilirubin uridine diphosphate (UDP)-glycosyltransferase (bilirubin UGT; UGT1A1) to form mono- and diglucuronides of bilirubin.	Bilirubin	38-47	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	105-108
11023036-7	2000	In the ER, bilirubin is conjugated by bilirubin uridine diphosphate (UDP)-glycosyltransferase (bilirubin UGT; UGT1A1) to form mono- and diglucuronides of bilirubin.	Bilirubin	38-47	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	110-116
10974422-7	2000	Activation of HO2 by phorbol esters, that stimulate protein kinase C to phosphorylate HO2, augments production of bilirubin which protects brain cultures from oxidative stress.	Bilirubin	114-123	heme oxygenase 2	Mus musculus	14-17
10974422-7	2000	Activation of HO2 by phorbol esters, that stimulate protein kinase C to phosphorylate HO2, augments production of bilirubin which protects brain cultures from oxidative stress.	Bilirubin	114-123	heme oxygenase 2	Mus musculus	86-89
11076395-5	2000	Prototypic endogenous substrates of high affinity for recombinant human MRP2 include bisglucuronosyl bilirubin, monoglucuronosyl bilirubin, and the glutathione S-conjugate leukotriene C4.	Bilirubin	101-110	ATP binding cassette subfamily C member 2	Homo sapiens	72-76
11982699-11	2002	Furthermore, serum IL-10 levels, but not IL-4 levels, were inversely correlated with serum total bilirubin concentrations (P = 0.045) and the death rate (p) outlined in Japan (P = 0.030).	Bilirubin	97-106	interleukin 10	Homo sapiens	19-24
11052272-7	2000	Regression analysis revealed a weak correlation between serum creatinine and ET-1 (r = 0.192, P = 0.04) and a significant correlation between serum bilirubin and ET-1 (r = 0.395, P < 0.001).	Bilirubin	148-157	endothelin 1	Homo sapiens	162-166
11052272-9	2000	Levels of ET-1 correlate with excretory liver function assessed by bilirubin.	Bilirubin	67-76	endothelin 1	Homo sapiens	10-14
10632337-10	1999	A multivariate logistic regression analysis including age, WBC count, percentage of peripheral and marrow blasts, hemoglobin, albumin, lactate dehydrogenase, bilirubin, and creatinine determined that a high level of caspase 3 was the most significant predictor of CR (P = 0.025, adjusted), with albumin the only other significant variable (P = 0.031).	Bilirubin	158-167	caspase 3	Homo sapiens	216-225
10603301-7	1999	The fluorescence quenching of the intrinsic tryptophan of L-PGDS due to the binding of bilirubin in the presence or absence of GdnHCl was measured.	Bilirubin	87-96	prostaglandin D2 synthase (brain)	Mus musculus	58-64
10603301-8	1999	The K(d) values obtained in the presence and absence of 0.5 M GdnHCl were 447 and 115 nM, respectively, indicating lower affinity of the L-PGDS for bilirubin with GdnHCl than without it.	Bilirubin	148-157	prostaglandin D2 synthase (brain)	Mus musculus	137-143
10622702-4	1999	Similar effects were observed after addition of bilirubin, which also exerted a significant protection against peroxynitrite-mediated modification of fibrinogen.	Bilirubin	48-57	fibrinogen beta chain	Homo sapiens	150-160
10583252-6	1999	In one patient an unusually high plasma bilirubin level was associated with the variant A[TA]7TAA configuration in the TATA box of the uridine diphosphate glucuronosyltransferase (UGT-1A) gene promoter, the mutation found in most patients with mild Gilbert"s syndrome.	Bilirubin	40-49	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	180-186
10604583-15	1999	CONCLUSION: Albumin dialysis is a new method for the effective treatment of fulminant Wilson disease, resulting in the removal of protein-bound toxins copper and bilirubin.	Bilirubin	162-171	albumin	Homo sapiens	12-19
10661682-6	1999	RESULTS: The 22 patients with calcium bilirubinate stones demonstrated NGF immunoreactivity associated with surrounding inflammatory cells that was localized to the epithelia of proliferative peribiliary glands in the ductal wall.	Bilirubin	30-50	nerve growth factor	Homo sapiens	71-74
10525116-12	1999	Collectively, the findings are consistent with the likelihood that suprainduction of HO-1 gene expression protects the kidney from free radical-mediated injury by increasing the capacity to produce the potent cellular antioxidant bilirubin.	Bilirubin	230-239	heme oxygenase 1	Rattus norvegicus	85-89
10562468-13	1999	We conclude that the bilirubin-oxidizing activity in brain mitochondrial membranes is cytochrome c dependent, but does not appear to be unequivocally identifiable as a cytochrome P450 oxidase.	Bilirubin	21-30	cytochrome c, somatic	Homo sapiens	86-98
10621943-8	1999	These results suggest that HO-1 induction may play an important role in conferring protection on cells from oxidative damage not only by catalyzing heme, a pro-oxidant, but also by producing bilirubin, an anti-oxidant.	Bilirubin	191-200	heme oxygenase 1	Rattus norvegicus	27-31
10521239-0	1999	Induction of heme oxygenase-1 suppresses venular leukocyte adhesion elicited by oxidative stress: role of bilirubin generated by the enzyme.	Bilirubin	106-115	heme oxygenase 1	Rattus norvegicus	13-29
10530498-6	1999	Likewise, changes in serum alanine aminotransferase (ALT) or bilirubin induced by CCl4 were less in rats after 96 h PH.	Bilirubin	61-70	C-C motif chemokine ligand 4	Rattus norvegicus	82-86
10551386-7	1999	Anti-SLA-positive patients tended to have lower transaminases (mean: 153 vs. 247 IU/l), gamma-globulins (25 vs. 31%) and bilirubin (1.8 vs. 3.3 mg/dl) in comparison to ANA/SMA positive patients, but there was a large overlap.	Bilirubin	121-130	Src like adaptor	Homo sapiens	5-8
10685306-1	1999	An ABO-incompatible term infant girl born to parents who are Jehovah"s Witnesses was admitted to our neonatal unit with a high serum bilirubin level necessitating exchange transfusion.	Bilirubin	133-142	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	3-6
10492239-4	1999	Bilirubin has been shown to inhibit responses of human lymphocytes, including phytohemagglutinin-induced proliferation, interleukin-2 production, and antibody dependent and independent cell mediated cytotoxicity.	Bilirubin	0-9	interleukin 2	Homo sapiens	120-133
10602774-4	1999	We demonstrated that bilirubin, formed from HO2, is neuroprotectant, as neurotoxicity is augmented in neuronal cultures from mice with targeted deletion of HO2 (HO2(-/-)) and reversed by low concentrations of bilirubin.	Bilirubin	21-30	heme oxygenase 2	Mus musculus	44-47
10602774-4	1999	We demonstrated that bilirubin, formed from HO2, is neuroprotectant, as neurotoxicity is augmented in neuronal cultures from mice with targeted deletion of HO2 (HO2(-/-)) and reversed by low concentrations of bilirubin.	Bilirubin	21-30	heme oxygenase 2	Mus musculus	156-159
10602774-4	1999	We demonstrated that bilirubin, formed from HO2, is neuroprotectant, as neurotoxicity is augmented in neuronal cultures from mice with targeted deletion of HO2 (HO2(-/-)) and reversed by low concentrations of bilirubin.	Bilirubin	21-30	heme oxygenase 2	Mus musculus	156-159
10602774-4	1999	We demonstrated that bilirubin, formed from HO2, is neuroprotectant, as neurotoxicity is augmented in neuronal cultures from mice with targeted deletion of HO2 (HO2(-/-)) and reversed by low concentrations of bilirubin.	Bilirubin	209-218	heme oxygenase 2	Mus musculus	44-47
10460761-9	1999	These findings suggest that HO-1 induction provides protection against H(2)O(2)-induced injury of the cultured human airway epithelial cells in part via the HO-bilirubin pathway.	Bilirubin	160-169	heme oxygenase 1	Homo sapiens	28-32
10462540-1	1999	UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) catalyzes the glucuronidation of bilirubin in liver.	Bilirubin	80-89	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-37
10462540-1	1999	UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) catalyzes the glucuronidation of bilirubin in liver.	Bilirubin	80-89	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	39-45
10462540-2	1999	Among all UGT isoforms identified to date, it is the only relevant bilirubin-glucuronidating enzyme in human.	Bilirubin	67-76	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	10-13
10468611-9	1999	Our results indicate that correction of the UGT1A1 genetic lesion in the Gunn rat restores enzyme expression and bilirubin conjugating activity, with consequent improvement in the metabolic abnormality.	Bilirubin	113-122	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	44-50
10425182-4	1999	Intraperitoneal administration of hemin, a HO-1 inducer, for 5 consecutive days resulted in about a 4-fold increase of serum bilirubin concentration.	Bilirubin	125-134	heme oxygenase 1	Rattus norvegicus	43-47
10421657-5	1999	UGT1A1 protein level correlated strongly with both liver microsomal bilirubin UGT activity and liver UGT1A1 mRNA level (r(2) =.82 and.72, respectively).	Bilirubin	68-77	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
10421658-0	1999	Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2.	Bilirubin	50-59	ATP binding cassette subfamily B member 4	Rattus norvegicus	89-119
10421658-2	1999	The bilirubin conjugates, monoglucuronosyl bilirubin (MGB) and bisglucuronosyl bilirubin (BGB), were previously suggested to be endogenous substrates for the apical multidrug resistance protein (MRP2), a member of the adenosine triphosphate (ATP)-binding cassette family of transporters (symbol ABCC2), also termed canalicular multispecific organic anion transporter.	Bilirubin	4-13	ATP binding cassette subfamily C member 2	Homo sapiens	195-199
10421658-2	1999	The bilirubin conjugates, monoglucuronosyl bilirubin (MGB) and bisglucuronosyl bilirubin (BGB), were previously suggested to be endogenous substrates for the apical multidrug resistance protein (MRP2), a member of the adenosine triphosphate (ATP)-binding cassette family of transporters (symbol ABCC2), also termed canalicular multispecific organic anion transporter.	Bilirubin	4-13	ATP binding cassette subfamily C member 2	Homo sapiens	295-300
10421658-2	1999	The bilirubin conjugates, monoglucuronosyl bilirubin (MGB) and bisglucuronosyl bilirubin (BGB), were previously suggested to be endogenous substrates for the apical multidrug resistance protein (MRP2), a member of the adenosine triphosphate (ATP)-binding cassette family of transporters (symbol ABCC2), also termed canalicular multispecific organic anion transporter.	Bilirubin	43-52	ATP binding cassette subfamily C member 2	Homo sapiens	195-199
10421658-2	1999	The bilirubin conjugates, monoglucuronosyl bilirubin (MGB) and bisglucuronosyl bilirubin (BGB), were previously suggested to be endogenous substrates for the apical multidrug resistance protein (MRP2), a member of the adenosine triphosphate (ATP)-binding cassette family of transporters (symbol ABCC2), also termed canalicular multispecific organic anion transporter.	Bilirubin	43-52	ATP binding cassette subfamily C member 2	Homo sapiens	295-300
10421658-9	1999	Our results provide direct evidence that recombinant MRP2, cloned from rat as well as human liver, mediates the primary-active ATP-dependent transport of the bilirubin conjugates MGB and BGB.	Bilirubin	158-167	ATP binding cassette subfamily C member 2	Rattus norvegicus	53-57
10423355-1	1999	Heme oxygenase (HO)-1 is a stress protein (HSP 32) and, together with HO-2, catalyses oxidation of the heme molecule to generate carbon monoxide, a gas with vasodilatory properties, and bilirubin, an antioxidant.	Bilirubin	186-195	heme oxygenase 1	Canis lupus familiaris	0-21
10423330-8	1999	Postoperative increase in serum bilirubin was closely correlated with the peripheral ET-1 at closure.	Bilirubin	32-41	endothelin 1	Homo sapiens	85-89
10459631-9	1999	Serum TGF-alpha levels exhibited a significant positive correlation with total bilirubin, ICGR15 and Pugh score (p<0.01, p<0.01 and p<0.05, respectively), and increased in parallel with severity of disease according to Child classification.	Bilirubin	79-88	transforming growth factor alpha	Homo sapiens	6-15
10408656-6	1999	The natural pigment melatonin and also water are of little influence to spectroscopic analysis of cerebral oxygenation, whereas bilirubin systematically lowers ScO2 and attenuates the detection of changes in cerebral oxygenation.	Bilirubin	128-137	synthesis of cytochrome C oxidase 2	Homo sapiens	160-164
10409239-2	1999	Overexpression of HO-1 in cells might, therefore, protect against oxidative stress produced by certain agents, specifically heme, by catalyzing its degradation to bilirubin, which by itself has antioxidant properties.	Bilirubin	163-172	heme oxygenase 1	Homo sapiens	18-22
10427418-1	1999	The kinetic analysis of the enzyme UDP-glucuronosyltransferase (UDPGT) responsible for the conjugation of bilirubin, suggest that it is a multisubunit enzyme in which there is cooperative binding of substrate to the subunits.	Bilirubin	106-115	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	35-62
10427418-1	1999	The kinetic analysis of the enzyme UDP-glucuronosyltransferase (UDPGT) responsible for the conjugation of bilirubin, suggest that it is a multisubunit enzyme in which there is cooperative binding of substrate to the subunits.	Bilirubin	106-115	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	64-69
10427418-2	1999	The binding of bilirubin to UDP-glucuronosyltransferase shows positive cooperativity with an apparent dissociation constant of 7.824 x 10(-4) +/- 6.405 x 10(-4) mM.	Bilirubin	15-24	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	28-55
10427418-3	1999	The apparent Hill coefficient for bilirubin to UDPGT is 2.9.	Bilirubin	34-43	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	47-52
10405174-0	1999	Specific sequence-directed anti-bilitranslocase antibodies as a tool to detect potentially bilirubin-binding proteins in different tissues of the rat.	Bilirubin	91-100	ceruloplasmin	Rattus norvegicus	32-47
10347328-11	1999	However, baseline IGF-1 levels showed a negative significant correlation (r = -0.76, P <.01) with total bilirubin and a positive correlation (r = 0.72, P <.01) with pseudocholinesterase.	Bilirubin	107-116	insulin like growth factor 1	Homo sapiens	18-23
10416058-0	1999	Bilirubin-human serum albumin interaction monitored by capillary zone electrophoresis.	Bilirubin	0-9	albumin	Homo sapiens	16-29
10416058-1	1999	Capillary zone electrophoresis was used to monitor the interaction between bilirubin and human serum albumin.	Bilirubin	75-84	albumin	Homo sapiens	95-108
10416058-5	1999	Approximately two bilirubin dianions could be bound per human serum albumin molecule in the cord blood serum.	Bilirubin	18-27	albumin	Homo sapiens	62-75
10471066-0	1999	UDP-glucuronosyltransferase (UGT1A1*28 and UGT1A6*2) polymorphisms in Caucasians and Asians: relationships to serum bilirubin concentrations.	Bilirubin	116-125	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	0-27
10427468-14	1999	Not only for the UGT1A gene, which reduces bilirubin glucuronidation, leading to genetic hyperbilirubinaemia (the Crigler-Najjar and Gilbert"s syndromes), but also for 3 other UGT isoforms.	Bilirubin	43-52	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	17-22
10427468-14	1999	Not only for the UGT1A gene, which reduces bilirubin glucuronidation, leading to genetic hyperbilirubinaemia (the Crigler-Najjar and Gilbert"s syndromes), but also for 3 other UGT isoforms.	Bilirubin	43-52	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	17-20
10397614-0	1999	Interaction between two dicarboxylate endogenous substances, bilirubin and an uremic toxin, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid, on human serum albumin.	Bilirubin	61-70	albumin	Homo sapiens	152-165
10397614-1	1999	PURPOSE: Two dicarboxylate endogenous substances, bilirubin (BR) and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), have a very high affinity to human serum albumin (HSA).	Bilirubin	50-59	albumin	Homo sapiens	162-175
10397614-1	1999	PURPOSE: Two dicarboxylate endogenous substances, bilirubin (BR) and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), have a very high affinity to human serum albumin (HSA).	Bilirubin	61-63	albumin	Homo sapiens	162-175
10628605-12	1999	In addition, circulating ICAM-1 at day 0 showed a significant correlation with the highest serum bilirubin observed during the entire study period (r2 = 0.963).	Bilirubin	97-106	intercellular adhesion molecule 1	Homo sapiens	25-31
10448912-3	1999	HO-1 participates in biological reaction leading to the formation of the antioxidant, bilirubin and the putative cellular messenger, carbon monoxide.	Bilirubin	86-95	heme oxygenase 1	Sus scrofa	0-4
10353933-2	1999	We studied whether the condition was associated with mutations in the gene for bilirubin uridine 5"-diphosphate-glucuronosyltransferase (UGT1A1), a key enzyme of bilirubin catabolism.	Bilirubin	79-88	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	137-143
10353933-2	1999	We studied whether the condition was associated with mutations in the gene for bilirubin uridine 5"-diphosphate-glucuronosyltransferase (UGT1A1), a key enzyme of bilirubin catabolism.	Bilirubin	162-171	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	137-143
10353933-3	1999	DESIGN: We analyzed the UGT1A1 gene in 25 Japanese neonates who had nonphysiologic hyperbilirubinemia (serum bilirubin >257 micromol/L) with no obvious cause.	Bilirubin	88-97	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	24-30
10471066-0	1999	UDP-glucuronosyltransferase (UGT1A1*28 and UGT1A6*2) polymorphisms in Caucasians and Asians: relationships to serum bilirubin concentrations.	Bilirubin	116-125	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	29-35
10471066-0	1999	UDP-glucuronosyltransferase (UGT1A1*28 and UGT1A6*2) polymorphisms in Caucasians and Asians: relationships to serum bilirubin concentrations.	Bilirubin	116-125	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	43-51
10471066-2	1999	Mutations in the promoter of the UGT1A1 gene (UGT1A1*28), resulting in 5, 7 or 8, instead of 6 thymine-adenine (TA) repeats, alter bilirubin conjugation.	Bilirubin	131-140	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	33-39
10471066-2	1999	Mutations in the promoter of the UGT1A1 gene (UGT1A1*28), resulting in 5, 7 or 8, instead of 6 thymine-adenine (TA) repeats, alter bilirubin conjugation.	Bilirubin	131-140	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	46-52
10471066-7	1999	Within both ethnic groups, serum bilirubin increased with increased numbers of UGT1A1 promoter TA repeats (P = 0.0001).	Bilirubin	33-42	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	79-85
10471066-8	1999	However, a strong ethnic group-by-UGT1A1 genotype interaction suggests that additional ethnic differences in bilirubin metabolism contribute to observed bilirubin concentrations.	Bilirubin	109-118	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	34-40
10471066-8	1999	However, a strong ethnic group-by-UGT1A1 genotype interaction suggests that additional ethnic differences in bilirubin metabolism contribute to observed bilirubin concentrations.	Bilirubin	153-162	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	34-40
10340924-0	1999	Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism.	Bilirubin	87-96	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	140-146
10340924-2	1999	UGT1A1, also catalyzing the glucuronidation of bilirubin, has been shown to have reduced activity in Gilbert"s syndrome.	Bilirubin	47-56	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
10359058-3	1999	The increase of unconjugated bilirubin level during fabic crisis and its relationship with UGT1A polymorphism was evaluated.	Bilirubin	29-38	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	91-96
10220490-7	1999	From the known substrate specificities of UGT1A4 toward lamotrigine and bilirubin and our activity and inhibition data, we conclude that UGT1A4 is a major retigabine N-glucuronosyl transferase in vivo and significantly contributes to the enterohepatic cycling of the drug.	Bilirubin	72-81	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	42-48
10220490-7	1999	From the known substrate specificities of UGT1A4 toward lamotrigine and bilirubin and our activity and inhibition data, we conclude that UGT1A4 is a major retigabine N-glucuronosyl transferase in vivo and significantly contributes to the enterohepatic cycling of the drug.	Bilirubin	72-81	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	137-143
10430302-5	1999	RESULTS: Serum endothelin-1 levels decreased rapidly in the good bilirubin decrease group after biliary drainage.	Bilirubin	65-74	endothelin 1	Homo sapiens	15-27
10396871-4	1999	Serum levels of triglycerides, total cholesterol, GOT, GPT, gamma-GTP, total bilirubin, and conjugated bilirubin were associated with the blood concentration of PCB adjusting for sex, age, drinking habit, smoking habit and body mass index (BMI).	Bilirubin	77-86	pyruvate carboxylase	Homo sapiens	161-164
10396871-4	1999	Serum levels of triglycerides, total cholesterol, GOT, GPT, gamma-GTP, total bilirubin, and conjugated bilirubin were associated with the blood concentration of PCB adjusting for sex, age, drinking habit, smoking habit and body mass index (BMI).	Bilirubin	103-112	pyruvate carboxylase	Homo sapiens	161-164
10396871-8	1999	The associations of serum levels of GOT, GPT, gamma-GTP, total bilirubin and conjugated bilirubin to the PCB level were not significant.	Bilirubin	88-97	pyruvate carboxylase	Homo sapiens	105-108
10430302-6	1999	Endothelin-1 levels decreased 1 week after drainage but then increased gradually in the worse bilirubin decrease group.	Bilirubin	94-103	endothelin 1	Homo sapiens	0-12
10430302-7	1999	Serum hepatocyte growth factor levels decreased gradually after biliary drainage, and were higher in the worse bilirubin decrease group than in the good bilirubin decrease group throughout the study.	Bilirubin	111-120	hepatocyte growth factor	Homo sapiens	6-30
10430302-7	1999	Serum hepatocyte growth factor levels decreased gradually after biliary drainage, and were higher in the worse bilirubin decrease group than in the good bilirubin decrease group throughout the study.	Bilirubin	153-162	hepatocyte growth factor	Homo sapiens	6-30
10430302-9	1999	Measurement of hepatocyte growth factor levels in patients with obstructive jaundice before percutaneous transhepatic cholangio drainage may be an early clinical predictor of the subsequent rate of decrease of the serum bilirubin concentration.	Bilirubin	220-229	hepatocyte growth factor	Homo sapiens	15-39
15818994-0	1999	[SERS of bilirubin and its complexes].	Bilirubin	9-18	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	1-5
15818994-1	1999	SERS spectra of bilirubin and its complexes were determined in Ag sol by the technique of the connection between NIR-FT-Raman and SERS.	Bilirubin	16-25	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	130-134
10229732-14	1999	Four of 7 patients receiving the 800-mg loading dose followed by 400 mg BID and 1 of 6 patients who received the 200-mg BID maintenance dose showed a small rise in bilirubin, and 3 patients had increases in transaminases; the mean values at 72 hours remained under twice the upper limit of normal.	Bilirubin	164-173	BH3 interacting domain death agonist	Homo sapiens	120-123
10215814-9	1999	The bile IL-6 concentration on day 1 after operation exhibited a significant negative correlation with the maximum serum total bilirubin concentration after hepatectomy.	Bilirubin	127-136	interleukin 6	Homo sapiens	9-13
15818994-1	1999	SERS spectra of bilirubin and its complexes were determined in Ag sol by the technique of the connection between NIR-FT-Raman and SERS.	Bilirubin	16-25	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	0-4
10190918-2	1999	The aim of this study was to investigate whether a genetic mutation in the bilirubin UGT1A1 gene, which has been associated with Gilbert"s syndrome in adults, is a contributory factor in prolonged neonatal jaundice.	Bilirubin	75-84	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	85-91
10081544-6	1999	The increase of TBil had its peak 1 day after anesthesia in both groups.	Bilirubin	16-20	pseudopodium enriched atypical kinase 1	Homo sapiens	29-35
10365905-8	1999	The AFP and CA 19-9 values also correlated with the total serum bilirubin level.	Bilirubin	64-73	alpha fetoprotein	Homo sapiens	4-7
10051662-0	1999	Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury.	Bilirubin	0-9	heme oxygenase 2	Mus musculus	35-51
10051662-3	1999	We demonstrate a neuroprotective role for BR formed from HO2.	Bilirubin	42-44	heme oxygenase 2	Mus musculus	57-60
10051662-4	1999	Neurotoxicity elicited by hydrogen peroxide in hippocampal and cortical neuronal cultures is prevented by the phorbol ester, phorbol 12-myristate 13-acetate (PMA) via stimulation of protein kinase C. We observe phosphorylation of HO2 through the protein kinase C pathway with enhancement of HO2 catalytic activity and accumulation of BR in neuronal cultures.	Bilirubin	334-336	heme oxygenase 2	Mus musculus	230-233
10051662-4	1999	Neurotoxicity elicited by hydrogen peroxide in hippocampal and cortical neuronal cultures is prevented by the phorbol ester, phorbol 12-myristate 13-acetate (PMA) via stimulation of protein kinase C. We observe phosphorylation of HO2 through the protein kinase C pathway with enhancement of HO2 catalytic activity and accumulation of BR in neuronal cultures.	Bilirubin	334-336	heme oxygenase 2	Mus musculus	291-294
10024515-2	1999	cMOAT-deficient Wistar rats (TR-) are mutated in the gene encoding cMOAT, leading to defective hepatobiliary transport of a whole range of substrates, including bilirubin glucuronide.	Bilirubin	161-170	ATP binding cassette subfamily C member 2	Rattus norvegicus	0-5
10024515-2	1999	cMOAT-deficient Wistar rats (TR-) are mutated in the gene encoding cMOAT, leading to defective hepatobiliary transport of a whole range of substrates, including bilirubin glucuronide.	Bilirubin	161-170	ATP binding cassette subfamily C member 2	Rattus norvegicus	67-72
10203145-0	1999	Additive effect of tumor necrosis factor-alpha and endotoxin on bilirubin cytotoxicity.	Bilirubin	64-73	tumor necrosis factor	Mus musculus	19-46
10203145-3	1999	The horseradish peroxidase oxidation method was applied for bilirubin-albumin titration studies to test the effect of endotoxin and TNF-alpha on bilirubin-albumin binding.	Bilirubin	145-154	tumor necrosis factor	Mus musculus	132-141
10203145-8	1999	Our results have shown that TNF-alpha and endotoxin increase the cytotoxicity of bilirubin.	Bilirubin	81-90	tumor necrosis factor	Mus musculus	28-37
10206483-7	1999	During low-dose CCK stimulation, HG significantly (p < 0.05) reduced bilirubin and trypsin output compared with control.	Bilirubin	72-81	cholecystokinin	Homo sapiens	16-19
10206483-12	1999	CCK-stimulated pancreatic enzyme and bilirubin output is significantly reduced only during hyperglycemia.	Bilirubin	37-46	cholecystokinin	Homo sapiens	0-3
10070038-7	1999	Elevations of serum aspartate aminotransferase, alkaline phosphatase, and total bilirubin levels by CCl4 were also enhanced by intracisternal CRF injection.	Bilirubin	80-89	C-C motif chemokine ligand 4	Rattus norvegicus	100-104
10088654-8	1999	However, concentrations of bilirubin equal to or exceeding 30 mg/dL and a bilirubin:BSA ratio of one were associated with increased protein oxidation, decreased erythrocyte glucose-6 phosphate dehydrogenase and adenosine triphosphatase activity, and altered cell membrane integrity.	Bilirubin	27-36	glucose-6-phosphate dehydrogenase	Homo sapiens	173-206
10030290-2	1999	Cox proportional hazards regression analysis identified five variables that demonstrated independent simultaneous prognostic value in estimating patient survival after retransplantation: (1) age group (pediatric or adult), (2) recipient requiring preoperative mechanical ventilation, (3) donor organ cold ischemia > or =12 hr, (4) preoperative serum creatinine, and (5) preoperative serum total bilirubin.	Bilirubin	398-407	cytochrome c oxidase subunit 8A	Homo sapiens	0-3
10022654-9	1999	Cirrhotic patients with spider angiomas disclosed higher plasma levels of substance P (84.7+/-105.3, median 53.1 vs 34.5+/-30.7, median 25.8 pg/ml, p = 0.006) and serum levels of bilirubin (3.9+/-3.8, median 1.9 vs 1.9+/-1.9, median 1.2 mg/dl, p = 0.02) than those without.	Bilirubin	179-188	tachykinin precursor 1	Homo sapiens	74-85
10211415-9	1999	RESULTS: Serum bilirubin decreased more in the first week after biliary drainage in patients with GSA-Rmax > or = 0.60 (7.64 +/- 1.09 mg/Dl/wk) than in patients with GSA-Rmax < 0.60 (3.56 +/- 1.25 mg/DL/wk, p = 0.042).	Bilirubin	15-24	GNAS complex locus	Homo sapiens	98-101
10082670-1	1999	Lipopolysaccharides (LPS) induces intrahepatic cholestasis and canalicular multispecific organic anion transporter (CMOAT/MRP2) plays a central role in hepatic bilirubin transport.	Bilirubin	160-169	ATP binding cassette subfamily C member 2	Rattus norvegicus	116-121
10082670-1	1999	Lipopolysaccharides (LPS) induces intrahepatic cholestasis and canalicular multispecific organic anion transporter (CMOAT/MRP2) plays a central role in hepatic bilirubin transport.	Bilirubin	160-169	ATP binding cassette subfamily C member 2	Rattus norvegicus	122-126
10082670-5	1999	CMOAT/MRP2 mRNA expression was time- and dose-dependently decreased by LPS injection with a decrease in bile flow and an increase in serum bilirubin level.	Bilirubin	139-148	ATP binding cassette subfamily C member 2	Rattus norvegicus	0-5
10082670-5	1999	CMOAT/MRP2 mRNA expression was time- and dose-dependently decreased by LPS injection with a decrease in bile flow and an increase in serum bilirubin level.	Bilirubin	139-148	ATP binding cassette subfamily C member 2	Rattus norvegicus	6-10
10091405-2	1999	In this paper we tested the hypothesis related to the variability of the glucuronidation bilirubin rate which depends on the configuration of the A(TA)nTAA motif of the UGT1*1 glucuronosyltransferase gene promoter.	Bilirubin	89-98	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	169-175
10091406-11	1999	This polymorphism, as well as the (TA)7 one, is associated with an increased level of bilirubin and a significant reduction of transcription activity of the UGT1A1 gene.	Bilirubin	86-95	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	157-163
10102158-9	1999	In conclusion, HDIVIG therapy in newborns with ABO or Rh haemolytic diseases reduces haemolysis, serum bilirubin levels and the need for blood exchange transfusion, a procedure which has potential complications and carries a risk of mortality.	Bilirubin	103-112	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	47-50
10211415-9	1999	RESULTS: Serum bilirubin decreased more in the first week after biliary drainage in patients with GSA-Rmax > or = 0.60 (7.64 +/- 1.09 mg/Dl/wk) than in patients with GSA-Rmax < 0.60 (3.56 +/- 1.25 mg/DL/wk, p = 0.042).	Bilirubin	15-24	GNAS complex locus	Homo sapiens	169-172
10211415-10	1999	Postoperative bilirubin increased less in patients with GSA-Rmax > or = 0.60 (0.81 +/- 0.30 mg/dL) than in patients with GSA-Rmax < 0.60 (4.00 +/- 0.69 mg/DL, p = 0.0012).	Bilirubin	14-23	GNAS complex locus	Homo sapiens	56-59
10211415-11	1999	Multivariate analysis showed that GSA-Rmax significantly predicted the postoperative bilirubin increase (p = 0.020).	Bilirubin	85-94	GNAS complex locus	Homo sapiens	34-37
9884306-10	1999	Glucuronidation of bilirubin and acetaminophen, substrates of UGT1- isoenzymes, was not affected by adjuvant-induced arthritis.	Bilirubin	19-28	UDP glycosyltransferase 1 family, polypeptide A4, pseudogene	Rattus norvegicus	62-66
10206734-0	1998	Bilirubin binding activity of cytokeratin 18 isolated from the porcine liver.	Bilirubin	0-9	keratin 18	Mus musculus	30-44
10069525-6	1999	Secretin significantly (P<0.005-P<0.05) increased volume and bicarbonate output and CCK significantly (P<0.01) increased the output of bilirubin, pancreatic enzymes, bicarbonate and volume, both during normoglycemia and hyperglycemia.	Bilirubin	144-153	secretin	Homo sapiens	0-8
10069525-6	1999	Secretin significantly (P<0.005-P<0.05) increased volume and bicarbonate output and CCK significantly (P<0.01) increased the output of bilirubin, pancreatic enzymes, bicarbonate and volume, both during normoglycemia and hyperglycemia.	Bilirubin	144-153	cholecystokinin	Homo sapiens	90-93
9841869-3	1998	Bilirubin glucuronidation was stimulated by all three treatments; this was correlated with an increase in the UGT1A1 protein concentration in hepatic microsomes.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	110-116
9841869-6	1998	The sudden interruption of maternal glucose supply signals the enhanced expression of UGT1A1, giving a novel explanation for the physiological induction of bilirubin glucuronidation in newborn infants.	Bilirubin	156-165	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	86-92
10483769-4	1999	After the infusion of BCAA-enriched amino acid solution, the BTR increased substantially, being significantly higher in patients who had not suffered an elevation in total bilirubin after liver resection.	Bilirubin	172-181	AT-rich interaction domain 4B	Homo sapiens	22-26
10193374-3	1998	HO-1 catabolises heme to bilirubin, free iron and carbon monoxide (CO).	Bilirubin	25-34	heme oxygenase 1	Homo sapiens	0-4
9813049-6	1998	The order of potency of different ligands to compete against 55Fe-hemin binding to p22 HBP was hemin = protoporphyrin IX > coproporphyrin III > bilirubin > palmitic acid > all-trans-retinoic acid.	Bilirubin	150-159	heme binding protein 1	Mus musculus	83-90
9777464-5	1998	Chitosan encapsulated activated charcoal (ACCB) beads have been extensively investigated in our group for the removal of various toxins such as urea, creatinine, uric acid, bilirubin, etc.	Bilirubin	173-182	acetyl-CoA carboxylase beta	Homo sapiens	42-46
9949625-11	1998	In our study, increased levels of TNF-alpha, IL-6 and especially IL-8 correlated with hepatic or renal dysfunction as evaluated by increased bilirubin and creatinine in plasma, while pulmonary complications correlated only with increased IL-6 levels.	Bilirubin	141-150	tumor necrosis factor	Homo sapiens	34-43
9949625-11	1998	In our study, increased levels of TNF-alpha, IL-6 and especially IL-8 correlated with hepatic or renal dysfunction as evaluated by increased bilirubin and creatinine in plasma, while pulmonary complications correlated only with increased IL-6 levels.	Bilirubin	141-150	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
9877260-10	1998	The correlation between the IRL/BMI ratio and serum total bilirubin concentrations was significant (r = 0.417, P < 0.05) in the M-LC group, but not in the F-LC group.	Bilirubin	58-67	modulator of VRAC current 1	Homo sapiens	131-135
10204356-2	1998	Correlation is established between the level of total cholesterol and activity of alanine aminotransferase in blood serum of cirrhotic patients, it being particularly clear in portal cirrhosis (r = -0.85; P < 0.05), as well as significantly higher levels of total and indirect bilirubin and lower level of albumins in patients presenting with a reduced level of total cholesterol.	Bilirubin	280-289	glutamic--pyruvic transaminase	Homo sapiens	82-106
9803459-0	1998	Brain bilirubin content is increased in P-glycoprotein-deficient transgenic null mutant mice.	Bilirubin	6-15	phosphoglycolate phosphatase	Mus musculus	40-54
9803459-4	1998	bilirubin infusion would be increased in P-gp-deficient mdr1a null mutant transgenic mice (mdr1a(-/-)) compared with controls.	Bilirubin	0-9	phosphoglycolate phosphatase	Mus musculus	41-45
9803459-4	1998	bilirubin infusion would be increased in P-gp-deficient mdr1a null mutant transgenic mice (mdr1a(-/-)) compared with controls.	Bilirubin	0-9	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	56-61
9803459-4	1998	bilirubin infusion would be increased in P-gp-deficient mdr1a null mutant transgenic mice (mdr1a(-/-)) compared with controls.	Bilirubin	0-9	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	91-96
9803459-6	1998	Brain bilirubin content (mean +/- SEM) 10 min after infusion was significantly higher in mdr1a(-/-) (18.1 +/- 2.4 nmol/g) compared with (+/+) mice (10.4 +/- 1.0 nmol/g).	Bilirubin	6-15	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	89-94
9803459-7	1998	Brain bilirubin content declined 60 min after infusion but remained higher in mdr1a(-/-) (10.3 +/- 1.4 nmol/g) compared with (+/+) mice (5.3 +/- 0.9 nmol/g).	Bilirubin	6-15	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	78-83
9803459-9	1998	We conclude that P-gp-deficient mdr1a(-/-) mice have significantly higher brain bilirubin content compared with controls after an i.v.	Bilirubin	80-89	phosphoglycolate phosphatase	Mus musculus	17-21
9803459-9	1998	We conclude that P-gp-deficient mdr1a(-/-) mice have significantly higher brain bilirubin content compared with controls after an i.v.	Bilirubin	80-89	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	32-37
9803459-11	1998	These data suggest that 1) bilirubin is a substrate for P-gp and 2) the increased brain bilirubin content in mdr1a(-/-) mice is due to enhanced brain bilirubin influx.	Bilirubin	27-36	phosphoglycolate phosphatase	Mus musculus	56-66
9803459-11	1998	These data suggest that 1) bilirubin is a substrate for P-gp and 2) the increased brain bilirubin content in mdr1a(-/-) mice is due to enhanced brain bilirubin influx.	Bilirubin	27-36	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	109-114
9803459-11	1998	These data suggest that 1) bilirubin is a substrate for P-gp and 2) the increased brain bilirubin content in mdr1a(-/-) mice is due to enhanced brain bilirubin influx.	Bilirubin	88-97	phosphoglycolate phosphatase	Mus musculus	56-66
9803459-11	1998	These data suggest that 1) bilirubin is a substrate for P-gp and 2) the increased brain bilirubin content in mdr1a(-/-) mice is due to enhanced brain bilirubin influx.	Bilirubin	88-97	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	109-114
9803459-11	1998	These data suggest that 1) bilirubin is a substrate for P-gp and 2) the increased brain bilirubin content in mdr1a(-/-) mice is due to enhanced brain bilirubin influx.	Bilirubin	88-97	phosphoglycolate phosphatase	Mus musculus	56-66
9803459-11	1998	These data suggest that 1) bilirubin is a substrate for P-gp and 2) the increased brain bilirubin content in mdr1a(-/-) mice is due to enhanced brain bilirubin influx.	Bilirubin	88-97	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	109-114
9803459-12	1998	We speculate that BBB P-gp provides a protective effect against bilirubin neurotoxicity by reducing brain bilirubin influx.	Bilirubin	64-73	phosphoglycolate phosphatase	Mus musculus	22-26
9803459-12	1998	We speculate that BBB P-gp provides a protective effect against bilirubin neurotoxicity by reducing brain bilirubin influx.	Bilirubin	106-115	phosphoglycolate phosphatase	Mus musculus	22-26
9853701-10	1998	A significant correlation was found between IL-6 values and CRP, ALT, total bilirubin, GGT and creatinine, but not amylase.	Bilirubin	76-85	interleukin 6	Homo sapiens	44-48
9748558-3	1998	The Crigler-Najjar syndrome is caused by a defect in the gene which encodes bilirubin UDP-glucuronosyltransferase (UGT), whereas the Dubin-Johnson syndrome is characterized by a defect in the gene which encodes the canalicular bilirubin conjugate export pump of hepatocytes.	Bilirubin	76-85	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	86-113
9748558-3	1998	The Crigler-Najjar syndrome is caused by a defect in the gene which encodes bilirubin UDP-glucuronosyltransferase (UGT), whereas the Dubin-Johnson syndrome is characterized by a defect in the gene which encodes the canalicular bilirubin conjugate export pump of hepatocytes.	Bilirubin	76-85	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	115-118
9825299-1	1998	Serum albumin, when incubated with bilirubin prior to electrophoresis, was visualized as a yellow-colored band during the electrophoretic run and did not require any staining.	Bilirubin	35-44	albumin	Homo sapiens	0-13
9825299-0	1998	Visualization of serum albumin on electrophoretic gels using the specific ligand bilirubin.	Bilirubin	81-90	albumin	Homo sapiens	17-30
9751083-5	1998	Serum enzyme activities of alanine aminotransferase (ALT), alkaline phosphatase, and gamma-glutamyl transpeptidase (gamma-GTP) and bilirubin content increased about 2-, 3-, 2-, and 6-fold, respectively, after CCl4 intoxication (P < 0.05); L-NAME or AG cotreatment further increased the enzyme activities (P < 0.05).	Bilirubin	131-140	C-C motif chemokine ligand 4	Rattus norvegicus	209-213
9789638-1	1998	The most important steps of bilirubin metabolism involved in the pathophysiology of neonatal hyperbilirubinemia are: 1) hemoglobin degradation by heme oxygenase; 2) bilirubin binding to serum albumin; 3) bilirubin conjugation to acid glucoronic by glucoronyl transferase.	Bilirubin	28-37	heme oxygenase 2	Homo sapiens	146-163
9789638-1	1998	The most important steps of bilirubin metabolism involved in the pathophysiology of neonatal hyperbilirubinemia are: 1) hemoglobin degradation by heme oxygenase; 2) bilirubin binding to serum albumin; 3) bilirubin conjugation to acid glucoronic by glucoronyl transferase.	Bilirubin	98-107	heme oxygenase 2	Homo sapiens	146-163
9789638-1	1998	The most important steps of bilirubin metabolism involved in the pathophysiology of neonatal hyperbilirubinemia are: 1) hemoglobin degradation by heme oxygenase; 2) bilirubin binding to serum albumin; 3) bilirubin conjugation to acid glucoronic by glucoronyl transferase.	Bilirubin	98-107	heme oxygenase 2	Homo sapiens	146-163
9734404-4	1998	The anti-inflammatory properties of HO-1 are thought to rely on the ability of this enzyme to degrade heme and generate bilirubin, free iron and carbon monoxide.	Bilirubin	120-129	heme oxygenase 1	Rattus norvegicus	36-40
9721195-0	1998	Activation of the Ah receptor signal transduction pathway by bilirubin and biliverdin.	Bilirubin	61-70	aryl hydrocarbon receptor	Rattus norvegicus	18-29
9721195-3	1998	High plasma levels of the heme degradation product bilirubin (BR) in these animals prompted us to evaluate whether BR is an endogenous AhR agonist.	Bilirubin	115-117	aryl hydrocarbon receptor	Rattus norvegicus	135-138
9724685-6	1998	Using this principle, we previously demonstrated a decreased diconjugated bilirubin fraction in hyperbilirubinemic G-6-PD-deficient neonates compared with hyperbilirubinemic G-6-PD-normal controls, suggesting diminished bilirubin conjugation.	Bilirubin	74-83	glucose-6-phosphate dehydrogenase	Homo sapiens	115-121
9724685-6	1998	Using this principle, we previously demonstrated a decreased diconjugated bilirubin fraction in hyperbilirubinemic G-6-PD-deficient neonates compared with hyperbilirubinemic G-6-PD-normal controls, suggesting diminished bilirubin conjugation.	Bilirubin	101-110	glucose-6-phosphate dehydrogenase	Homo sapiens	115-121
9724685-8	1998	Therefore, we postulated that efficiency of bilirubin conjugation is a crucial factor in the development of hyperbilirubinemia in G-6-PD-deficient neonates.	Bilirubin	44-53	glucose-6-phosphate dehydrogenase	Homo sapiens	130-136
9724685-9	1998	We hypothesized that those G-6-PD-deficient neonates who develop hyperbilirubinemia would have decreased bilirubin conjugation ability, whereas those with a more efficient conjugating system would have a lesser degree of bilirubinemia.	Bilirubin	70-79	glucose-6-phosphate dehydrogenase	Homo sapiens	27-33
9702644-7	1998	RESULTS: Growth hormone treatment was associated with a significant decline in serum bilirubin (-34.6 +/- 16.5 mumol/l vs. 18.2 +/- 11.59 mumol/l; p < 0.02) but there was no significant effect on any anthropometric or body composition measurements, or on any biochemical or hematologic parameters.	Bilirubin	85-94	growth hormone 1	Homo sapiens	9-23
9738861-1	1998	Crigler-Najjar (CN) syndrome is a congenital familial nonhemolytic jaundice associated with high level of unconjugated bilirubin due to deficient uridine diphosphate glucuronosyltransferase (UDPG-T) activity in the liver.	Bilirubin	119-128	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	146-189
9692996-1	1998	A conserved hydrophobic region in the bilirubin-type UDP-glucuronosyltransferase isozyme was first uncovered as a consequence of a deleterious mutation in the UGT1A1 (HUG-Br1) isozyme of a Crigler-Najjar (CN) Type I patient.	Bilirubin	38-47	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	159-165
9692996-1	1998	A conserved hydrophobic region in the bilirubin-type UDP-glucuronosyltransferase isozyme was first uncovered as a consequence of a deleterious mutation in the UGT1A1 (HUG-Br1) isozyme of a Crigler-Najjar (CN) Type I patient.	Bilirubin	38-47	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	167-174
9692996-7	1998	The less hydrophobic buried helix in the phenolic-type UGT1A6 has a Tyr/Leu at position 170/171; this isoform glucuronidated bilirubin at 1/10 the level of that by UGT1A1 with a Km (bilirubin) of 25 microM compared to that for UGT1A1 of 5.	Bilirubin	125-134	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	55-61
9692996-7	1998	The less hydrophobic buried helix in the phenolic-type UGT1A6 has a Tyr/Leu at position 170/171; this isoform glucuronidated bilirubin at 1/10 the level of that by UGT1A1 with a Km (bilirubin) of 25 microM compared to that for UGT1A1 of 5.	Bilirubin	125-134	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	164-170
9692996-7	1998	The less hydrophobic buried helix in the phenolic-type UGT1A6 has a Tyr/Leu at position 170/171; this isoform glucuronidated bilirubin at 1/10 the level of that by UGT1A1 with a Km (bilirubin) of 25 microM compared to that for UGT1A1 of 5.	Bilirubin	125-134	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	227-233
9692996-7	1998	The less hydrophobic buried helix in the phenolic-type UGT1A6 has a Tyr/Leu at position 170/171; this isoform glucuronidated bilirubin at 1/10 the level of that by UGT1A1 with a Km (bilirubin) of 25 microM compared to that for UGT1A1 of 5.	Bilirubin	182-191	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	55-61
9692996-7	1998	The less hydrophobic buried helix in the phenolic-type UGT1A6 has a Tyr/Leu at position 170/171; this isoform glucuronidated bilirubin at 1/10 the level of that by UGT1A1 with a Km (bilirubin) of 25 microM compared to that for UGT1A1 of 5.	Bilirubin	182-191	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	164-170
9700954-7	1998	During hyperglycemia bombesin-stimulated 60-min outputs of bilirubin, trypsin, amylase, and bicarbonate were not significantly different compared to those during normoglycemia.	Bilirubin	59-68	gastrin releasing peptide	Homo sapiens	21-29
9828853-3	1998	HO-1 catabolises heme to bilirubin, free iron, and carbon monoxide (CO).	Bilirubin	25-34	heme oxygenase 1	Homo sapiens	0-4
11819306-2	1998	The serum total bilirubin (TBIL) and liver necrosis of mice increased after rTNF-alpha, rIL-6 or rIFN were used separately with D-GAL.	Bilirubin	16-25	tumor necrosis factor	Rattus norvegicus	76-86
11819306-4	1998	The serum TBIL of mice and the degree of liver necrosis increased after injection of IL-1, IL-6 with D-GAL and rTNF-alpha.CONCLUSION: Cytokines, like IL-1, IL-6, IFN&agr and TNF-&agr;joined in the process of hepatocyte necrosis.They can enhance the degree of liver necrosis induced by D-GAL.	Bilirubin	10-14	interleukin 1 complex	Mus musculus	85-89
11819306-4	1998	The serum TBIL of mice and the degree of liver necrosis increased after injection of IL-1, IL-6 with D-GAL and rTNF-alpha.CONCLUSION: Cytokines, like IL-1, IL-6, IFN&agr and TNF-&agr;joined in the process of hepatocyte necrosis.They can enhance the degree of liver necrosis induced by D-GAL.	Bilirubin	10-14	interleukin 6	Mus musculus	91-95
11819306-4	1998	The serum TBIL of mice and the degree of liver necrosis increased after injection of IL-1, IL-6 with D-GAL and rTNF-alpha.CONCLUSION: Cytokines, like IL-1, IL-6, IFN&agr and TNF-&agr;joined in the process of hepatocyte necrosis.They can enhance the degree of liver necrosis induced by D-GAL.	Bilirubin	10-14	tumor necrosis factor	Rattus norvegicus	111-121
11819306-4	1998	The serum TBIL of mice and the degree of liver necrosis increased after injection of IL-1, IL-6 with D-GAL and rTNF-alpha.CONCLUSION: Cytokines, like IL-1, IL-6, IFN&agr and TNF-&agr;joined in the process of hepatocyte necrosis.They can enhance the degree of liver necrosis induced by D-GAL.	Bilirubin	10-14	interleukin 6	Mus musculus	156-160
11819306-4	1998	The serum TBIL of mice and the degree of liver necrosis increased after injection of IL-1, IL-6 with D-GAL and rTNF-alpha.CONCLUSION: Cytokines, like IL-1, IL-6, IFN&agr and TNF-&agr;joined in the process of hepatocyte necrosis.They can enhance the degree of liver necrosis induced by D-GAL.	Bilirubin	10-14	tumor necrosis factor	Mus musculus	112-115
9726089-9	1998	SN-38 is eliminated mainly through conjugation by hepatic uridine glucuronosyltransferase (UGT*1.1), the same isoezyme responsible for glucuronidation of bilirubin.	Bilirubin	154-163	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	91-98
9578464-1	1998	Bilitranslocase is an organic anion carrier involved in bilirubin and phthalein uptake by the liver.	Bilirubin	56-65	ceruloplasmin	Rattus norvegicus	0-15
9653159-0	1998	Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism?	Bilirubin	117-126	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	57-63
9653159-9	1998	We suggest that the unstable UGT1A1 polymorphism may serve to "fine-tune" the plasma bilirubin level within population groups, maintaining it at a high enough level to provide protection against oxidative damage, but at a level that is sufficiently low to prevent kernicterus in infants.	Bilirubin	85-94	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	29-35
9639672-7	1998	The UGT1A1*32 protein supported 0-10% normal bilirubin glucuronidation when expressed in COS-1 cells.	Bilirubin	45-54	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	4-10
9639672-8	1998	The I294T coding defect seen at the second allele in SM (CN-II) generated the UGT1A1*33 mutant protein which supported 40-55% normal activity with a normal Km (2.5 microM) for bilirubin.	Bilirubin	176-185	5'-nucleotidase, cytosolic II	Homo sapiens	57-62
9639672-8	1998	The I294T coding defect seen at the second allele in SM (CN-II) generated the UGT1A1*33 mutant protein which supported 40-55% normal activity with a normal Km (2.5 microM) for bilirubin.	Bilirubin	176-185	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	78-84
9555089-1	1998	To evaluate whether a temporary hepatic insufficiency may affect intestinal glucuronidation, we determined UDP-glucuronosyltransferase activity towards bilirubin and p-nitrophenol in rat jejunum and liver after partial hepatectomy.	Bilirubin	152-161	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	107-134
9585479-11	1998	Exposure of human plasma to SIN-1 resulted in the loss of ascorbate followed by loss of CoQ10H2 and bilirubin.	Bilirubin	100-109	MAPK associated protein 1	Homo sapiens	28-33
9572292-1	1998	Heme oxygenase isozymes, HO-1 (also known as hsp32) and HO-2, are the source for the formation of the putative messenger molecule carbon monoxide (CO), reactive iron, and the in vitro antioxidant bilirubin.	Bilirubin	196-205	heme oxygenase 1	Mus musculus	25-29
9572292-1	1998	Heme oxygenase isozymes, HO-1 (also known as hsp32) and HO-2, are the source for the formation of the putative messenger molecule carbon monoxide (CO), reactive iron, and the in vitro antioxidant bilirubin.	Bilirubin	196-205	heme oxygenase 1	Mus musculus	45-50
9572292-1	1998	Heme oxygenase isozymes, HO-1 (also known as hsp32) and HO-2, are the source for the formation of the putative messenger molecule carbon monoxide (CO), reactive iron, and the in vitro antioxidant bilirubin.	Bilirubin	196-205	heme oxygenase 2	Mus musculus	56-60
9684114-4	1998	RESULTS: Serum IL-6 levels measured before and after PTCD in the slowly decreasing bilirubin group ("poor" group) were significantly higher than those of the rapidly decreasing bilirubin group ("good" group).	Bilirubin	83-92	interleukin 6	Homo sapiens	15-19
9684114-4	1998	RESULTS: Serum IL-6 levels measured before and after PTCD in the slowly decreasing bilirubin group ("poor" group) were significantly higher than those of the rapidly decreasing bilirubin group ("good" group).	Bilirubin	177-186	interleukin 6	Homo sapiens	15-19
15810303-0	1998	[FT-IR study on the solid-state reaction of bilirubin on BaF2].	Bilirubin	44-53	BANF family member 2	Homo sapiens	57-61
15810303-2	1998	In this paper the solid-state reaction of bilirubin on BaF2 was examined by FT-IR.	Bilirubin	42-51	BANF family member 2	Homo sapiens	55-59
15810303-4	1998	From the results the free radical mechanism is suggested in the solid-state reaction of bilirubin on BaF2.	Bilirubin	88-97	BANF family member 2	Homo sapiens	101-105
9497253-1	1998	Crigler-Najjar syndrome type 1 (CN-1) is a recessively inherited, potentially lethal disorder characterized by severe unconjugated hyperbilirubinemia resulting from deficiency of the hepatic enzyme bilirubin-UDP-glucuronosyltransferase.	Bilirubin	136-145	5'-nucleotidase, cytosolic IA	Homo sapiens	0-30
9580479-9	1998	Moreover, patients with PIIINP and bilirubin above normal levels had higher PICP, PINP, ICTP PYR, DPYR, CTX, and NTX.	Bilirubin	35-44	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	104-107
9497253-1	1998	Crigler-Najjar syndrome type 1 (CN-1) is a recessively inherited, potentially lethal disorder characterized by severe unconjugated hyperbilirubinemia resulting from deficiency of the hepatic enzyme bilirubin-UDP-glucuronosyltransferase.	Bilirubin	136-145	5'-nucleotidase, cytosolic IA	Homo sapiens	32-36
9497253-2	1998	In all CN-1 patients studied, structural mutations in one of the five exons of the gene (UGT1A1) encoding the uridinediphosphoglucuronate glucuronosyltransferase (UGT) isoform bilirubin-UGT1 were implicated in the absence or inactivation of the enzyme.	Bilirubin	176-185	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	89-95
9497253-2	1998	In all CN-1 patients studied, structural mutations in one of the five exons of the gene (UGT1A1) encoding the uridinediphosphoglucuronate glucuronosyltransferase (UGT) isoform bilirubin-UGT1 were implicated in the absence or inactivation of the enzyme.	Bilirubin	176-185	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	110-161
9497253-2	1998	In all CN-1 patients studied, structural mutations in one of the five exons of the gene (UGT1A1) encoding the uridinediphosphoglucuronate glucuronosyltransferase (UGT) isoform bilirubin-UGT1 were implicated in the absence or inactivation of the enzyme.	Bilirubin	176-185	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	89-92
9497253-2	1998	In all CN-1 patients studied, structural mutations in one of the five exons of the gene (UGT1A1) encoding the uridinediphosphoglucuronate glucuronosyltransferase (UGT) isoform bilirubin-UGT1 were implicated in the absence or inactivation of the enzyme.	Bilirubin	176-185	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	89-93
9497253-6	1998	Bilirubin-UGT1 mRNA is difficult to obtain, since it is expressed in the liver only.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	10-14
9507213-11	1998	Possible mechanisms by which HO-1 ameliorates disease include anti-complement or anti-oxidant effects of bilirubin and vasodilator and anti-platelet effects of carbon monoxide.	Bilirubin	105-114	heme oxygenase 1	Rattus norvegicus	29-33
9525311-2	1998	The Gunn rat is an accurate animal model of this disease because the bilirubin-UDPGT gene in this strain carries a premature stop codon.	Bilirubin	69-78	UDP glucuronosyltransferase family 1 member A5	Rattus norvegicus	79-84
9525311-6	1998	An Ad5 vector expressing the cDNA encoding human bilirubin-UDPGT (Ad5/CMV/hUG-Br1) was then generated and injected i.v.	Bilirubin	49-58	Alzheimer disease, familial, type 5	Homo sapiens	3-6
9525311-6	1998	An Ad5 vector expressing the cDNA encoding human bilirubin-UDPGT (Ad5/CMV/hUG-Br1) was then generated and injected i.v.	Bilirubin	49-58	UDP glucuronosyltransferase family 1 member A5	Rattus norvegicus	59-64
9525311-6	1998	An Ad5 vector expressing the cDNA encoding human bilirubin-UDPGT (Ad5/CMV/hUG-Br1) was then generated and injected i.v.	Bilirubin	49-58	Alzheimer disease, familial, type 5	Homo sapiens	66-69
9525311-9	1998	Although the mean level of bilirubin in homozygous Gunn rats 1-2 days after birth was already 14.5-fold higher than that of heterozygous siblings, treatment with Ad5/CMV/hUG-Br1 reduced plasma bilirubin to normal levels within 1 week.	Bilirubin	27-36	Alzheimer disease, familial, type 5	Homo sapiens	162-165
9525311-9	1998	Although the mean level of bilirubin in homozygous Gunn rats 1-2 days after birth was already 14.5-fold higher than that of heterozygous siblings, treatment with Ad5/CMV/hUG-Br1 reduced plasma bilirubin to normal levels within 1 week.	Bilirubin	27-36	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	170-177
9525311-9	1998	Although the mean level of bilirubin in homozygous Gunn rats 1-2 days after birth was already 14.5-fold higher than that of heterozygous siblings, treatment with Ad5/CMV/hUG-Br1 reduced plasma bilirubin to normal levels within 1 week.	Bilirubin	193-202	Alzheimer disease, familial, type 5	Homo sapiens	162-165
9525311-9	1998	Although the mean level of bilirubin in homozygous Gunn rats 1-2 days after birth was already 14.5-fold higher than that of heterozygous siblings, treatment with Ad5/CMV/hUG-Br1 reduced plasma bilirubin to normal levels within 1 week.	Bilirubin	193-202	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	170-177
9525311-11	1998	Administration of Ad5-mediated gene therapy to neonatal Gunn rats effectively complemented the deficiency in bilirubin-UDPGT, resulting in substantial reductions in plasma bilirubin over a 3-month period.	Bilirubin	109-118	Alzheimer disease, familial, type 5	Homo sapiens	18-21
9525311-11	1998	Administration of Ad5-mediated gene therapy to neonatal Gunn rats effectively complemented the deficiency in bilirubin-UDPGT, resulting in substantial reductions in plasma bilirubin over a 3-month period.	Bilirubin	109-118	UDP glucuronosyltransferase family 1 member A5	Rattus norvegicus	119-124
9525311-11	1998	Administration of Ad5-mediated gene therapy to neonatal Gunn rats effectively complemented the deficiency in bilirubin-UDPGT, resulting in substantial reductions in plasma bilirubin over a 3-month period.	Bilirubin	172-181	Alzheimer disease, familial, type 5	Homo sapiens	18-21
9737578-6	1998	In contrast, the mRNA level of UGT1*1 (which metabolizes bilirubin, not phenols) was depressed to 16% of control (P<0.002), while the mRNA level of UGT2B3 (which metabolizes testosterone) was reduced to 53% (P<0.05).	Bilirubin	57-66	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	31-37
9754048-1	1998	Treatment with hepatotoxin namely carbon tetrachloride (CCl4) (0.1 ml/100 g of body weight; twice a week) induced acute hepatic necrosis in Swiss albino mice (male; body weight 30 g +/- 2), with significant alteration in the activities of glutamic oxaloacetic transaminase (GOT); glutamic pyruvic transaminase (GPT); alkaline phosphatase (AP) and serum bilirubin.	Bilirubin	353-362	chemokine (C-C motif) ligand 4	Mus musculus	56-60
9503160-0	1998	Comparison of bilirubin binding and other molecular properties of the serum albumin of several mammalian species.	Bilirubin	14-23	albumin	Homo sapiens	76-83
12515175-4	1998	As the expression of TGF-beta 3 increased, the level of serum bilirubin ascended and plasmozyme activity was prolonged.	Bilirubin	62-71	transforming growth factor beta 3	Homo sapiens	21-31
9457971-1	1998	Conjugation with glucuronic acid, mediated by bilirubin-uridinediphosphoglucuronate glucuronosyltransferase (bilirubin-UGT), is essential for efficient biliary excretion of bilirubin.	Bilirubin	46-55	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	119-122
9407320-2	1998	Overexpression of HO-1 in endothelial cells (EC) might, therefore, protect against oxidative stress produced under these pathological conditions, by generation of CO, a vasodilator, and bilirubin, which has antioxidant properties that enhance blood vessel formation to counteract hypoxia-induced injury.	Bilirubin	186-195	heme oxygenase 1	Homo sapiens	18-22
9457971-1	1998	Conjugation with glucuronic acid, mediated by bilirubin-uridinediphosphoglucuronate glucuronosyltransferase (bilirubin-UGT), is essential for efficient biliary excretion of bilirubin.	Bilirubin	109-118	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	119-122
9457971-1	1998	Conjugation with glucuronic acid, mediated by bilirubin-uridinediphosphoglucuronate glucuronosyltransferase (bilirubin-UGT), is essential for efficient biliary excretion of bilirubin.	Bilirubin	109-118	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	119-122
9457971-3	1998	To develop a gene therapy for bilirubin-UGT deficiency, we constructed a high-titer replication-deficient amphotropic recombinant retrovirus (MFG-S hB-UGT1) capable of transferring the gene encoding bilirubin-UGT1, the principal bilirubin-UGT isoform in human liver.	Bilirubin	30-39	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	40-43
9457971-3	1998	To develop a gene therapy for bilirubin-UGT deficiency, we constructed a high-titer replication-deficient amphotropic recombinant retrovirus (MFG-S hB-UGT1) capable of transferring the gene encoding bilirubin-UGT1, the principal bilirubin-UGT isoform in human liver.	Bilirubin	199-208	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	151-155
9457971-8	1998	In MFG-S hB-UGT1-perfused rats, but not in controls, expression of human bilirubin-UGT1 was shown by immunotransblotting, bilirubin-UGT assay of liver homogenates, and biliary excretion of bilirubin diglucuronide and monoglucuronide.	Bilirubin	73-82	UDP glycosyltransferase 1 family, polypeptide A4, pseudogene	Rattus norvegicus	12-16
9457971-8	1998	In MFG-S hB-UGT1-perfused rats, but not in controls, expression of human bilirubin-UGT1 was shown by immunotransblotting, bilirubin-UGT assay of liver homogenates, and biliary excretion of bilirubin diglucuronide and monoglucuronide.	Bilirubin	73-82	UDP glycosyltransferase 1 family, polypeptide A4, pseudogene	Rattus norvegicus	83-87
9457971-8	1998	In MFG-S hB-UGT1-perfused rats, but not in controls, expression of human bilirubin-UGT1 was shown by immunotransblotting, bilirubin-UGT assay of liver homogenates, and biliary excretion of bilirubin diglucuronide and monoglucuronide.	Bilirubin	73-82	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	12-15
9457971-8	1998	In MFG-S hB-UGT1-perfused rats, but not in controls, expression of human bilirubin-UGT1 was shown by immunotransblotting, bilirubin-UGT assay of liver homogenates, and biliary excretion of bilirubin diglucuronide and monoglucuronide.	Bilirubin	122-131	UDP glycosyltransferase 1 family, polypeptide A4, pseudogene	Rattus norvegicus	83-87
9457971-8	1998	In MFG-S hB-UGT1-perfused rats, but not in controls, expression of human bilirubin-UGT1 was shown by immunotransblotting, bilirubin-UGT assay of liver homogenates, and biliary excretion of bilirubin diglucuronide and monoglucuronide.	Bilirubin	122-131	UDP glycosyltransferase 1 family, polypeptide A4, pseudogene	Rattus norvegicus	83-87
9397986-7	1997	Inhibition of glucuronidation reduces the availability of bilirubin and rhodamine glucuronates for transport via cmoat, but unconjugated cationic rhodamine becomes available for transport via Pgp at an increased cellular concentration.	Bilirubin	58-67	ATP binding cassette subfamily C member 2	Rattus norvegicus	113-118
9397986-2	1997	We tested whether genistein, a modulator of drug resistance in tumor cells, affects biliary secretion of substrates of canalicular multispecific organic anion transporter (cmoat) (glucuronides of bilirubin and rhodamine, glutathione conjugate of bromsulphthalein) and of P-glycoprotein (Pgp) (rhodamine), respectively.	Bilirubin	196-205	ATP binding cassette subfamily C member 2	Rattus norvegicus	119-170
9875554-4	1998	A comparison of the transport properties across the bile canalicular membrane in normal and mutant rats, whose cMOAT function is hereditarily defective, has shown that the physiologic role of cMOAT is to excrete LTC4, bilirubin glucuronides, 171-estradiol-170-D-glucuronide, and reduced folates.	Bilirubin	218-227	ATP binding cassette subfamily C member 2	Rattus norvegicus	192-197
9397986-2	1997	We tested whether genistein, a modulator of drug resistance in tumor cells, affects biliary secretion of substrates of canalicular multispecific organic anion transporter (cmoat) (glucuronides of bilirubin and rhodamine, glutathione conjugate of bromsulphthalein) and of P-glycoprotein (Pgp) (rhodamine), respectively.	Bilirubin	196-205	ATP binding cassette subfamily C member 2	Rattus norvegicus	172-177
9362347-8	1997	The bile HGF concentration on postoperative day 1 exhibited a significant negative correlation with the maximum concentration of serum total bilirubin after hepatectomy.	Bilirubin	141-150	hepatocyte growth factor	Homo sapiens	9-12
9472554-8	1997	Bilirubin conjugation activity could be detected in microsomes from Gunn rat hepatocytes after transfection with two different B-UDPGT expression constructs.	Bilirubin	0-9	UDP glucuronosyltransferase family 2 member B15	Rattus norvegicus	129-134
9402154-8	1997	The level of HO activity in endothelial cells exposed to heme or TNF-alpha was increased from 24.7 +/- 5.7 pmol bilirubin/mg protein/min in control to 70.0 +/- 9.5 and 36.7 +/- 3.1 pmol bilirubin/mg protein/min in heme- and TNF-alpha-stimulated cells, respectively.	Bilirubin	112-121	tumor necrosis factor	Homo sapiens	65-74
9402154-8	1997	The level of HO activity in endothelial cells exposed to heme or TNF-alpha was increased from 24.7 +/- 5.7 pmol bilirubin/mg protein/min in control to 70.0 +/- 9.5 and 36.7 +/- 3.1 pmol bilirubin/mg protein/min in heme- and TNF-alpha-stimulated cells, respectively.	Bilirubin	186-195	tumor necrosis factor	Homo sapiens	65-74
9406655-5	1997	Inherited deficiencies in UGT forms are deleterious, as exemplified by the debilitating effects of hyperbilirubinaemia and neurotoxicity in subjects with mutations in the enzyme that converts bilirubin to its more polar glucuronide.	Bilirubin	104-113	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	26-29
9375768-2	1997	High levels of bilirubin could be related to the co-inherited Gilbert"s syndrome, determined either by mutations of the coding region or by variation in the A(TA)nTAA motif of the promoter of the bilirubin UDP-glucuronosyltransferase gene (UGT-1).	Bilirubin	15-24	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	240-245
9375768-7	1997	Five beta-thalassaemia heterozygotes, who were homozygous for the extra (TA) bases in the A(TA)nTAA element of the promoter of UGT-1A, the configuration present in homozygosity in Gilbert"s syndrome, had higher bilirubin levels compared to those with the (TA)6/(TA)7 or (TA)6/(TA)6 configurations.	Bilirubin	211-220	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	127-133
9375769-3	1997	Nearly 80% of patients with increased bilirubin levels were heterozygous or homozygous for the UGT1A TA(7) variant associated with Gilbert"s syndrome.	Bilirubin	38-47	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	95-100
9505992-9	1997	Serial determinations of total bilirubin were explored as a potential pharmacodynamic marker for P-glycoprotein inhibition.	Bilirubin	31-40	ATP binding cassette subfamily B member 1	Homo sapiens	97-111
9361342-13	1997	AT III prevented the continuous rise in total serum bilirubin concentration observed in control patients and diminished the frequency of artificial renal support therapy (p < .05).	Bilirubin	52-61	serpin family C member 1	Homo sapiens	0-6
9394598-9	1997	In patients with athetoid cerebral palsy, brainstem dysfunctions, and abnormal ABR, localization of MRI lesions to the pallidum and subthalamic nuclei is evidence for neonatal bilirubin encephalopathy.	Bilirubin	176-185	ABR activator of RhoGEF and GTPase	Homo sapiens	79-82
9342374-5	1997	Thirty (22.9%) G-6-PD deficient neonates developed serum total bilirubin >/= 257 micromol/liter, vs. 22 (9.2%) normals (P = 0.0005).	Bilirubin	63-72	glucose-6-phosphate dehydrogenase	Homo sapiens	15-21
9205782-13	1997	In CCl4 poisoning it is suggested to start UDCA treatment as early as possible and to continue it for some more days after improvement of serum bilirubin concentration.	Bilirubin	144-153	C-C motif chemokine ligand 4	Rattus norvegicus	3-7
9355767-2	1997	We demonstrate for the first time that ATP-dependent transport of both bilirubin glucuronides is mediated by the multidrug resistance protein (MRP1) as well as by the distinct canalicular (apical) isoform MRP2, also termed cMRP or cMOAT (canalicular multispecific organic anion transporter).	Bilirubin	71-80	ATP binding cassette subfamily C member 1	Homo sapiens	143-147
9355767-2	1997	We demonstrate for the first time that ATP-dependent transport of both bilirubin glucuronides is mediated by the multidrug resistance protein (MRP1) as well as by the distinct canalicular (apical) isoform MRP2, also termed cMRP or cMOAT (canalicular multispecific organic anion transporter).	Bilirubin	71-80	ATP binding cassette subfamily C member 2	Homo sapiens	205-209
9355767-2	1997	We demonstrate for the first time that ATP-dependent transport of both bilirubin glucuronides is mediated by the multidrug resistance protein (MRP1) as well as by the distinct canalicular (apical) isoform MRP2, also termed cMRP or cMOAT (canalicular multispecific organic anion transporter).	Bilirubin	71-80	ATP binding cassette subfamily C member 2	Homo sapiens	223-227
9355767-2	1997	We demonstrate for the first time that ATP-dependent transport of both bilirubin glucuronides is mediated by the multidrug resistance protein (MRP1) as well as by the distinct canalicular (apical) isoform MRP2, also termed cMRP or cMOAT (canalicular multispecific organic anion transporter).	Bilirubin	71-80	ATP binding cassette subfamily C member 2	Homo sapiens	231-236
9355767-2	1997	We demonstrate for the first time that ATP-dependent transport of both bilirubin glucuronides is mediated by the multidrug resistance protein (MRP1) as well as by the distinct canalicular (apical) isoform MRP2, also termed cMRP or cMOAT (canalicular multispecific organic anion transporter).	Bilirubin	71-80	ATP binding cassette subfamily C member 2	Homo sapiens	238-289
9338624-7	1997	Bilirubin levels, at day of IL-8 peak, did not differ statistically between mild and severe VOD.	Bilirubin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
9365042-7	1997	p53 antibody positivity was associated with bilirubin and the number of tumors (p=0.027 and p=0.018, respectively).	Bilirubin	44-53	tumor protein p53	Homo sapiens	0-3
9360082-5	1997	Levels of HA and IL-8 had good correlation with the level of TB (HA: r = 0.60, p < 0.05; IL-8: r = 0.55, p < 0.05).	Bilirubin	61-63	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
9360082-5	1997	Levels of HA and IL-8 had good correlation with the level of TB (HA: r = 0.60, p < 0.05; IL-8: r = 0.55, p < 0.05).	Bilirubin	61-63	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
9276739-10	1997	These results suggest that HO-1 induced by mildly oxidized LDL may protect against the induction of inflammatory responses in artery wall cells through the production of the antioxidants biliverdin and bilirubin.	Bilirubin	202-211	heme oxygenase 1	Homo sapiens	27-31
9252066-1	1997	BACKGROUND/AIMS: Gilbert"s syndrome is genetically characterized by an extra TA element in the TATAA-box of the promotor region upstream of the bilirubin UDP-glucuronosyltransferase (UGT1A) coding region (Bosma et al.	Bilirubin	144-153	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	183-188
9252066-10	1997	CONCLUSIONS: This study shows that liver graft recipients with persistent unconjugated hyperbilirubinemia may have received a liver from a donor with an abnormal TATAA-box in the bilirubin UGT1A-gene promotor region.	Bilirubin	92-101	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	189-194
9249878-1	1997	beta-Glucuronidase of human or bacterial origin may deconjugate bilirubin diglucuronide, causing pigment gallstones.	Bilirubin	64-73	glucuronidase beta	Homo sapiens	0-18
9180251-6	1997	In addition, serum bilirubin correlated positively with HDL cholesterol and inversely with triglycerides, VLDL cholesterol, LDL cholesterol, insulin, glucose and systolic blood pressure although these correlations were significant only in certain age-race-sex groups.	Bilirubin	19-28	insulin	Homo sapiens	141-148
9355767-0	1997	ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2.	Bilirubin	27-36	ATP binding cassette subfamily C member 1	Homo sapiens	86-90
9355767-0	1997	ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2.	Bilirubin	27-36	ATP binding cassette subfamily C member 2	Homo sapiens	130-134
9315660-10	1997	These results establish C/EBP alpha as an essential transcriptional regulator of genes encoding enzymes involved in bilirubin detoxification and gluconeogenesis in adult mouse liver.	Bilirubin	116-125	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	24-35
9380021-0	1997	Aryl hydrocarbon receptor-dependent induction of cyp1a1 by bilirubin in mouse hepatoma hepa 1c1c7 cells.	Bilirubin	59-68	aryl-hydrocarbon receptor	Mus musculus	0-25
9380021-0	1997	Aryl hydrocarbon receptor-dependent induction of cyp1a1 by bilirubin in mouse hepatoma hepa 1c1c7 cells.	Bilirubin	59-68	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	49-55
9380021-2	1997	We examined the ability of exogenously added hemin, biliverdin, or bilirubin to regulate Cyp1a1, an enzyme that may be active in bilirubin elimination.	Bilirubin	67-76	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	89-95
9380021-2	1997	We examined the ability of exogenously added hemin, biliverdin, or bilirubin to regulate Cyp1a1, an enzyme that may be active in bilirubin elimination.	Bilirubin	129-138	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	89-95
9380021-6	1997	Of the three compounds, bilirubin produced the greatest maximal increase in Cyp1a1 mRNA and EROD (5.5-, 10.5-, and 15-fold for 100 microM hemin, biliverdin, and bilirubin, respectively) activity.	Bilirubin	24-33	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	76-82
9380021-6	1997	Of the three compounds, bilirubin produced the greatest maximal increase in Cyp1a1 mRNA and EROD (5.5-, 10.5-, and 15-fold for 100 microM hemin, biliverdin, and bilirubin, respectively) activity.	Bilirubin	161-170	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	76-82
9380021-9	1997	In contrast, EROD induction by hemin, biliverdin, or bilirubin was completely blocked by cycloheximide treatment, indicating that the increase in enzyme activity is dependent on increased Cyp1a1 apoprotein synthesis.	Bilirubin	53-62	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	188-194
9380021-12	1997	Gel retardation assays demonstrated that bilirubin, but not hemin or biliverdin, was able to transform the AHR to a form capable of specifically binding to a 32P-labeled oligonucleotide containing a dioxin-response element sequence.	Bilirubin	41-50	aryl-hydrocarbon receptor	Mus musculus	107-110
9380021-13	1997	These data indicate that bilirubin induces Cyp1a1 gene transcription through direct interaction with the AHR.	Bilirubin	25-34	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	43-49
9380021-13	1997	These data indicate that bilirubin induces Cyp1a1 gene transcription through direct interaction with the AHR.	Bilirubin	25-34	aryl-hydrocarbon receptor	Mus musculus	105-108
9380021-14	1997	In contrast, hemin and biliverdin seem to induce Cyp1a1 indirectly by serving as precursors to the endogenous formation of bilirubin via normal heme metabolism pathways.	Bilirubin	123-132	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	49-55
9380021-15	1997	This is the first direct demonstration that the endogenous heme metabolite bilirubin can directly regulate Cyp1a1 gene expression and enzymatic activity in an AHR-dependent manner.	Bilirubin	75-84	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	107-113
9380021-15	1997	This is the first direct demonstration that the endogenous heme metabolite bilirubin can directly regulate Cyp1a1 gene expression and enzymatic activity in an AHR-dependent manner.	Bilirubin	75-84	aryl-hydrocarbon receptor	Mus musculus	159-162
9224784-0	1997	Glucuronidation of retinoids by rat recombinant UDP: glucuronosyltransferase 1.1 (bilirubin UGT).	Bilirubin	82-91	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	48-80
9224784-0	1997	Glucuronidation of retinoids by rat recombinant UDP: glucuronosyltransferase 1.1 (bilirubin UGT).	Bilirubin	82-91	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	92-95
9264316-0	1997	Differential effect of hypophysectomy and growth hormone treatment on hepatic glucuronosyltransferases in male rats: evidence for an action at a pretranslational level for isoforms glucuronidating bilirubin.	Bilirubin	197-206	gonadotropin releasing hormone receptor	Rattus norvegicus	42-56
9264316-4	1997	GH induced a decrease in several glucuronidation activities: bilirubin glucuronidation in both sham-operated and cortisol/ thyroxine-treated hypophysectomized rats in a dose-dependent manner, testosterone glucuronidation in hypophysectomized animals, and androsterone and estrone glucuronidation in cortisol/thyroxin-treated hypophysectomized rats.	Bilirubin	61-70	gonadotropin releasing hormone receptor	Rattus norvegicus	0-2
9264316-9	1997	Variations in protein amounts were correlated to variations in bilirubin, testosterone and androsterone conjugation activities induced by hypophysectomy and GH treatment.	Bilirubin	63-72	gonadotropin releasing hormone receptor	Rattus norvegicus	157-159
9213259-6	1997	Insulin-glucagon therapy was given for normalization of transaminases and then withdrawn 3 weeks after admission, but it was resumed at 3 months, resulting in a dramatic decrease in serum bilirubin levels, which then normalized in 2.5 months.	Bilirubin	188-197	insulin	Homo sapiens	0-7
9130390-3	1997	Our results are noteworthy as SnPP is being used for the amelioration and management of hyperbilirubinemia, and they emphasize that the combined dosing of retinoic acid and SnPP attenuates the suppression of the activity of HMOX, thereby decreasing plasma bilirubin levels.	Bilirubin	93-102	heme oxygenase 1	Rattus norvegicus	224-228
9158817-6	1997	It is likely that the first applications of NIR will be where there is a requirement for multiple assays such as glucose, urea and bilirubin and where sample size is a limitation.	Bilirubin	131-140	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	44-47
9205782-7	1997	One hour after CCl4 administration bilirubin started to increase and reached its peak in the second hour.	Bilirubin	35-44	C-C motif chemokine ligand 4	Rattus norvegicus	15-19
9095612-6	1997	After the decrease in CRP, the decrease in total bilirubin concentration was delayed.	Bilirubin	49-58	C-reactive protein	Homo sapiens	22-25
9480242-0	1997	[Relationship between erythropoietin activity in fetal blood and Liley"s curve and bilirubin concentration in amniotic fluid in serologic conflict].	Bilirubin	83-92	erythropoietin	Homo sapiens	22-36
9480242-2	1997	There was conducted the trial of settle correlation between EPO activity in fetal blood and bilirubin concentration in amniotic fluid and its optical density ratio obtained by amniopuncture in the same pregnancies.	Bilirubin	92-101	erythropoietin	Homo sapiens	60-63
9058743-6	1997	PAI-1 (mean +/- SD) was significantly (P < .001) elevated in patients with VOD (321.6 +/- 161.2 ng/mL) as compared with patients with GVHD (22.8 +/- 8.4 ng/mL) or other hepatic damage (32.8 +/- 30.8 ng/mL) at the timepoint of bilirubin increase.	Bilirubin	229-238	serpin family E member 1	Homo sapiens	0-5
9058743-7	1997	At the peak bilirubin concentration, the corresponding PAI-1 levels were 426.1 +/- 230.0 ng/mL in patients with VOD, 41.0 +/- 20.6 ng/ mL in patients with GVHD, and 44.6 +/- 32.9 ng/mL in patients with other hepatic injury (P < .001 VOD v GVHD/other hepatic injury).	Bilirubin	12-21	serpin family E member 1	Homo sapiens	55-60
9112245-9	1997	Bilirubin was negatively correlated to insulin and visceral AT in men and women.	Bilirubin	0-9	insulin	Homo sapiens	39-46
9385081-19	1997	Visualization of cellular HO-2 expression aids in assessment of potential sites of carbon monoxide, iron, and bilirubin production within the nervous system.	Bilirubin	110-119	heme oxygenase 2	Rattus norvegicus	26-30
9141436-10	1997	Hepatic steady-state NTCP mRNA levels in a group of 23 pre- and postportoenterostomy biliary atresia patients were inversely related to total bilirubin, indicating that extrahepatic bile duct obstruction leads to down-regulation of NTCP mRNA levels, similar to that observed in rat common bile duct ligation.	Bilirubin	142-151	solute carrier family 10 member 1	Homo sapiens	21-25
9151948-5	1997	Moreover, feeding of ascorbic acid suppressed the hepatic mRNA level of heme oxygenase-1, the rate-limiting enzyme of bilirubin biosynthesis, in rats injected with lipopolysaccharide.	Bilirubin	118-127	heme oxygenase 1	Rattus norvegicus	72-88
9174115-4	1997	Interestingly, treatment with a known inducer of UGT bilirubin, ciprofibrate, induced the hepatic mRNA levels encoding for the UGT1*0 isoform by 3.5-fold and for the UGT1*1 isoform by only twofold.	Bilirubin	53-62	UDP glucuronosyltransferase 1 family, polypeptide A2	Rattus norvegicus	127-133
9174115-4	1997	Interestingly, treatment with a known inducer of UGT bilirubin, ciprofibrate, induced the hepatic mRNA levels encoding for the UGT1*0 isoform by 3.5-fold and for the UGT1*1 isoform by only twofold.	Bilirubin	53-62	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	166-172
9116047-10	1997	The increase in the HO-2 transcript was accompanied by an increase in HO-2 protein, as assessed by Western blot analysis, and an increase in HO activity, as measured by bilirubin formation.	Bilirubin	169-178	heme oxygenase 2	Homo sapiens	20-24
9084013-9	1997	The incidence of infants with a direct bilirubin > 2.0 mg/dL was 24% and 43% in the CCK+ and CCK- groups, respectively, and was not significant (p = .14).	Bilirubin	39-48	cholecystokinin	Homo sapiens	87-90
9030219-4	1997	From these protection experiments, the Ka for the complex of bilitranslocase with either bilirubin or nicotinic acid has been estimated to be 2.1 and 10.8 nM.	Bilirubin	89-98	ceruloplasmin	Rattus norvegicus	61-76
9029056-3	1997	The present study was designed to compare the reactivity and relative glucuronidation efficiencies of opioid agonists, antagonists, and partial agonists with two rat UGT isoforms; UGT1.1, which is generally considered the "bilirubin UGT," and UGT2B1, which has previously been shown to catalyze the glucuronidation of testosterone, chloramphenicol, and (-)-morphine.	Bilirubin	223-232	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	180-186
9028453-1	1997	Characterization of the UGT1 gene complex locus encoding both multiple bilirubin and phenol UDP-glucuronosyltransferases (transferases) has been critical in identifying mutations in the bilirubin isoforms.	Bilirubin	71-80	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	24-28
9028453-1	1997	Characterization of the UGT1 gene complex locus encoding both multiple bilirubin and phenol UDP-glucuronosyltransferases (transferases) has been critical in identifying mutations in the bilirubin isoforms.	Bilirubin	186-195	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	24-28
9028453-2	1997	This study utilizes this information to identify the bases of deficient bilirubin UDP-glucuronosyltransferase activity encoded by the UGT1A gene for the major bilirubin isozyme, HUG-Br1, in 3 Crigler-Najjar type I individuals and the genotype of an at-risk unborn sibling of one patient.	Bilirubin	72-81	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	134-139
9028453-2	1997	This study utilizes this information to identify the bases of deficient bilirubin UDP-glucuronosyltransferase activity encoded by the UGT1A gene for the major bilirubin isozyme, HUG-Br1, in 3 Crigler-Najjar type I individuals and the genotype of an at-risk unborn sibling of one patient.	Bilirubin	72-81	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	178-185
9124378-1	1997	Hemoglobin (Hb) induces heme oxygenase-1 (HO-1), which catalyzes the breakdown of heme to bilirubin, and ferritin.	Bilirubin	90-99	heme oxygenase 1	Rattus norvegicus	24-40
9124378-1	1997	Hemoglobin (Hb) induces heme oxygenase-1 (HO-1), which catalyzes the breakdown of heme to bilirubin, and ferritin.	Bilirubin	90-99	heme oxygenase 1	Rattus norvegicus	42-46
9188761-6	1997	CCK significantly (p<0.05) increased bilirubin, amylase and trypsin output both during normo- and hyperglycemia.	Bilirubin	40-49	cholecystokinin	Homo sapiens	0-3
9043030-10	1997	Bilirubin concentrations in the serum were increased after VM26 plus CSA compared with VM26 alone (P<0.01).	Bilirubin	0-9	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	69-72
9296445-12	1997	The incubation of HSA with reducing agents such as uric acid or bilirubin in the presence of high Cu concentrations, produces a "peroxidase-like" activity, capable of breaking down hydrogen peroxide as well as lipid hydroperoxides.	Bilirubin	64-73	albumin	Homo sapiens	18-21
8989992-3	1997	Therefore, mammals have a liver enzyme bilirubin UDP-glucuronosyltransferase (B-UGT), which conjugates bilirubin with glucuronic acid, thereby making the molecule much more water soluble.	Bilirubin	39-48	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	49-76
8989992-5	1997	Patients with Crigler-Najjar (CN) disease have a deficiency in bilirubin UDP-glucuronosyltransferase and accumulate high serum levels of bilirubin.	Bilirubin	63-72	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	73-100
9188761-7	1997	During the initial 30 min of CCK infusion the bilirubin, amylase and trypsin outputs were significantly (p<0.05) inhibited in the hyperglycemic experiment compared to normoglycemia.	Bilirubin	46-55	cholecystokinin	Homo sapiens	29-32
9027647-0	1996	Deconjugation of bilirubin accelerates coprecipitation of cholesterol, fatty acids, and mucin in human bile--in vitro study.	Bilirubin	17-26	LOC100508689	Homo sapiens	88-93
9027422-3	1996	Medium containing 6 mumol/1 bilirubin and increasing concentrations of human serum albumin giving ratios of 0.5-1.5 that resulted in an increase of the free bilirubin concentrations.	Bilirubin	157-166	albumin	Homo sapiens	77-90
9213968-5	1997	Elevation of serum myoglobin as a manifestation of specific myositis is pathognomic for leptospirosis and contributes to the onset of acute renal failure and disturbance of bilirubin metabolism.	Bilirubin	173-182	myoglobin	Homo sapiens	19-28
8986214-4	1996	Correlations with parameters of liver injury (i.e., ascites, encephalopathy, AST bilirubin, and protime) all showed a more significant correlation with HGF concentrations than those of AFP.	Bilirubin	81-90	hepatocyte growth factor	Homo sapiens	152-155
9027647-7	1996	Bilirubin, cholesterol, fatty acids, and mucin were found to coprecipitate in accordance with bilirubin deconjugation, which process may play an important role in an early stage of the formation of brown pigment gallstones.	Bilirubin	94-103	LOC100508689	Homo sapiens	41-46
8876628-4	1996	Further incubation of bilirubin-treated PBMNC with irradiated B lymphoid Raji cells after removal of the extracellular bilirubin resulted in a dose-dependent decrease of cytotoxic T lymphocyte (CTL) activity, DNA synthesis, and expression of Tac antigen (CD25) and transferrin receptor (CD71).	Bilirubin	22-31	interleukin 2 receptor subunit alpha	Homo sapiens	242-253
10879229-6	1996	Raised ALP in the presence of normal bilirubin was more often a feature of HCC than BLD although this relationship was not statistically significant.	Bilirubin	37-46	alkaline phosphatase, placental	Homo sapiens	7-10
8876628-4	1996	Further incubation of bilirubin-treated PBMNC with irradiated B lymphoid Raji cells after removal of the extracellular bilirubin resulted in a dose-dependent decrease of cytotoxic T lymphocyte (CTL) activity, DNA synthesis, and expression of Tac antigen (CD25) and transferrin receptor (CD71).	Bilirubin	22-31	interleukin 2 receptor subunit alpha	Homo sapiens	255-259
8876628-4	1996	Further incubation of bilirubin-treated PBMNC with irradiated B lymphoid Raji cells after removal of the extracellular bilirubin resulted in a dose-dependent decrease of cytotoxic T lymphocyte (CTL) activity, DNA synthesis, and expression of Tac antigen (CD25) and transferrin receptor (CD71).	Bilirubin	22-31	transferrin receptor	Homo sapiens	265-285
8876628-4	1996	Further incubation of bilirubin-treated PBMNC with irradiated B lymphoid Raji cells after removal of the extracellular bilirubin resulted in a dose-dependent decrease of cytotoxic T lymphocyte (CTL) activity, DNA synthesis, and expression of Tac antigen (CD25) and transferrin receptor (CD71).	Bilirubin	22-31	transferrin receptor	Homo sapiens	287-291
8876628-6	1996	These results suggest that bilirubin inhibits the induction of CTL activity, and this defect may result from the impaired responsiveness against IL-2.	Bilirubin	27-36	interleukin 2	Homo sapiens	145-149
9131487-0	1996	The novel UGT1 gene complex links bilirubin, xenobiotics, and therapeutic drug metabolism by encoding UDP-glucuronosyltransferase isozymes with a common carboxyl terminus.	Bilirubin	34-43	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	10-14
9131487-2	1996	The human bilirubin and phenol transferases are encoded by the same gene complex which we designate UGT1.	Bilirubin	10-19	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	100-104
9131487-8	1996	The gene arrangement, in conjunction with the toxicity data from the Gunn rat, leads to the prediction that detoxification of bilirubin, xenobiotics, and therapeutic drugs is linked to the UGT1 locus.	Bilirubin	126-135	UDP glycosyltransferase 1 family, polypeptide A4, pseudogene	Rattus norvegicus	189-193
8806713-2	1996	We have previously shown that rat UGT1.1, stably expressed in human embryonic kidney 293 cells, catalyzes the glucuronidation of bilirubin and the mixed opioid agonist/antagonist buprenorphine with high efficiency.	Bilirubin	129-138	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	34-40
9048262-7	1996	RESULTS: Decreasing serum bilirubin concentration was associated with older age, increased prevalence of smoking, higher body mass index and systolic blood pressure, increased glycated haemoglobin, fasting and 2 h insulin, triglyceride, very-low-density lipoprotein and apolipoprotein B concentrations, and lower high-density lipoprotein concentration.	Bilirubin	26-35	insulin	Homo sapiens	214-221
9048262-7	1996	RESULTS: Decreasing serum bilirubin concentration was associated with older age, increased prevalence of smoking, higher body mass index and systolic blood pressure, increased glycated haemoglobin, fasting and 2 h insulin, triglyceride, very-low-density lipoprotein and apolipoprotein B concentrations, and lower high-density lipoprotein concentration.	Bilirubin	26-35	apolipoprotein B	Homo sapiens	270-286
9048262-12	1996	When analysed as a continuous variable by age-adjusted partial correlation coefficients, serum bilirubin concentration was inversely correlated with fasting insulin, triglyceride, very-low-density lipoprotein and glycated haemoglobin level.	Bilirubin	95-104	insulin	Homo sapiens	157-164
8902994-4	1996	In LC patients, the sTPO level was not correlated with the platelet count, but was correlated with prothrombin time, activated partial thromboplastin time, and total bilirubin, indicating that production of TPO in the liver decreases slightly with the development of liver dysfunction.	Bilirubin	166-175	thyroid peroxidase	Homo sapiens	21-24
8912353-13	1996	The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert"s syndrome.	Bilirubin	47-56	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	57-84
8875114-7	1996	Cholinesterase, total bilirubin, circulating thrombocytes and blood area nitrogen were the independent predictors of the concentration of soluble VCAM-1.	Bilirubin	22-31	vascular cell adhesion molecule 1	Homo sapiens	146-152
8810807-4	1996	For the hepatic uptake of non-bile acid-organic anions such as bilirubin, at least 4 transporters are postulated, i.e., bilirubin/BSP binding protein (BBBP), organic anion binding protein (OABP), bilitranslocase, and organic anion transporting polypeptide (OATP).	Bilirubin	63-72	ATP binding cassette subfamily E member 1	Homo sapiens	158-187
8634340-6	1996	When bilirubin-treated PBL were cultured with interleukin-2 (IL-2), a dose-dependent decrease of lymphokine-activated killing activity, ADCC activity, and DNA synthesis was observed.	Bilirubin	5-14	interleukin 2	Homo sapiens	46-59
8810807-4	1996	For the hepatic uptake of non-bile acid-organic anions such as bilirubin, at least 4 transporters are postulated, i.e., bilirubin/BSP binding protein (BBBP), organic anion binding protein (OABP), bilitranslocase, and organic anion transporting polypeptide (OATP).	Bilirubin	63-72	ATP binding cassette subfamily E member 1	Homo sapiens	189-193
8810807-4	1996	For the hepatic uptake of non-bile acid-organic anions such as bilirubin, at least 4 transporters are postulated, i.e., bilirubin/BSP binding protein (BBBP), organic anion binding protein (OABP), bilitranslocase, and organic anion transporting polypeptide (OATP).	Bilirubin	63-72	solute carrier organic anion transporter family member 1A2	Homo sapiens	217-255
8810807-4	1996	For the hepatic uptake of non-bile acid-organic anions such as bilirubin, at least 4 transporters are postulated, i.e., bilirubin/BSP binding protein (BBBP), organic anion binding protein (OABP), bilitranslocase, and organic anion transporting polypeptide (OATP).	Bilirubin	63-72	solute carrier organic anion transporter family member 1A2	Homo sapiens	257-261
8810807-6	1996	The gene for UDP-glucuronosyltransferase (UGT) 1 family has been elucidated and differential splicing from several exons 1 (A to J) results in forming isozymes of UGT 1 including bilirubin UGT.	Bilirubin	179-188	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	13-48
8810807-6	1996	The gene for UDP-glucuronosyltransferase (UGT) 1 family has been elucidated and differential splicing from several exons 1 (A to J) results in forming isozymes of UGT 1 including bilirubin UGT.	Bilirubin	179-188	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	163-168
8810807-6	1996	The gene for UDP-glucuronosyltransferase (UGT) 1 family has been elucidated and differential splicing from several exons 1 (A to J) results in forming isozymes of UGT 1 including bilirubin UGT.	Bilirubin	179-188	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	42-45
8679227-14	1996	The magnitude of HO-1 induction after oxidative stress and the wide distribution of this enzyme in systemic tissues coupled with the intriguing biological activities of the catalytic byproducts, carbon monoxide, iron, and bilirubin, makes HO-1 a highly attractive and interesting candidate stress-response protein which may play key role(s) in mediating protection against oxidant-mediated lung injury.	Bilirubin	222-231	heme oxygenase 1	Homo sapiens	17-21
8679227-14	1996	The magnitude of HO-1 induction after oxidative stress and the wide distribution of this enzyme in systemic tissues coupled with the intriguing biological activities of the catalytic byproducts, carbon monoxide, iron, and bilirubin, makes HO-1 a highly attractive and interesting candidate stress-response protein which may play key role(s) in mediating protection against oxidant-mediated lung injury.	Bilirubin	222-231	heme oxygenase 1	Homo sapiens	239-243
8840238-5	1996	A significant correlation was observed between plasma IL-8 levels and serum bilirubin levels (r = 0.72; P < 0.001).	Bilirubin	76-85	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
8689926-0	1996	Intracellular accumulation of unconjugated bilirubin inhibits phytohemagglutin-induced proliferation and interleukin-2 production of human lymphocytes.	Bilirubin	43-52	interleukin 2	Homo sapiens	105-118
8689926-9	1996	IL-2 production by bilirubin-treated PBMNC after PHA stimulation was significantly decreased compared to bilirubin-untreated PBMNC.	Bilirubin	19-28	interleukin 2	Homo sapiens	0-4
8689926-9	1996	IL-2 production by bilirubin-treated PBMNC after PHA stimulation was significantly decreased compared to bilirubin-untreated PBMNC.	Bilirubin	105-114	interleukin 2	Homo sapiens	0-4
8689926-11	1996	Expression of Tac antigen and transferrin receptor on bilirubin-treated lymphocytes after PHA stimulation was not significantly different from bilirubin-untreated cells.	Bilirubin	54-63	interleukin 2 receptor subunit alpha	Homo sapiens	14-25
8689926-11	1996	Expression of Tac antigen and transferrin receptor on bilirubin-treated lymphocytes after PHA stimulation was not significantly different from bilirubin-untreated cells.	Bilirubin	54-63	transferrin	Homo sapiens	30-41
8689926-12	1996	These results suggest that decreased PHA-induced T-lymphocyte proliferation following bilirubin-pretreatment may result from impairment of proliferation at a step beyond transferrin receptor expression.	Bilirubin	86-95	transferrin	Homo sapiens	170-181
8660358-5	1996	The hepatic mRNA level of heme oxygenase-1 (HO-1), the rate limiting enzyme of bilirubin biosynthesis, reached a maximum after 4 hours.	Bilirubin	79-88	heme oxygenase 1	Rattus norvegicus	26-42
8667253-2	1996	They show that the stress on the target organ, the kidney, is translated into a response in the cardiovascular system, as reflected by the induction of heme oxygenase (HO)-1 gene expression, which, in turn, may be a cellular defense response as suggested by an increase in cGMP level in the heart, and an increase in the rate of bilirubin formation by the kidney and the heart.	Bilirubin	329-338	heme oxygenase 1	Rattus norvegicus	152-173
8667253-3	1996	HO-1 is a stress protein (HSP32) and, together with HO-2, catalyzes oxidation of the heme molecule to generate CO, a likely signal molecule for the generation of cGMP, and bilirubin, an antioxidant.	Bilirubin	172-181	heme oxygenase 1	Rattus norvegicus	0-4
8667253-3	1996	HO-1 is a stress protein (HSP32) and, together with HO-2, catalyzes oxidation of the heme molecule to generate CO, a likely signal molecule for the generation of cGMP, and bilirubin, an antioxidant.	Bilirubin	172-181	heme oxygenase 1	Rattus norvegicus	26-31
8667253-3	1996	HO-1 is a stress protein (HSP32) and, together with HO-2, catalyzes oxidation of the heme molecule to generate CO, a likely signal molecule for the generation of cGMP, and bilirubin, an antioxidant.	Bilirubin	172-181	heme oxygenase 2	Rattus norvegicus	52-56
8667253-7	1996	The increase in heart HO-1 transcript level was accompanied by an increase in HO-1 protein, as judged by Western blot and immunohistochemical analysis, and in enzyme activity, as judged by bilirubin formation.	Bilirubin	189-198	heme oxygenase 1	Rattus norvegicus	22-26
8634340-6	1996	When bilirubin-treated PBL were cultured with interleukin-2 (IL-2), a dose-dependent decrease of lymphokine-activated killing activity, ADCC activity, and DNA synthesis was observed.	Bilirubin	5-14	interleukin 2	Homo sapiens	61-65
8634340-8	1996	These results suggest that bilirubin inhibits major histocompatibility complex-unrestricted cytotoxicity in both unstimulated and IL-2 stimulated lymphocytes.	Bilirubin	27-36	interleukin 2	Homo sapiens	130-134
9156798-16	1996	Significant drops in serum bilirubin levels were noted following expression of HUG Br1 but not beta-galactosidase.	Bilirubin	27-36	C-X-C motif chemokine ligand 11	Homo sapiens	83-86
8792313-10	1996	A third MDR-related protein has been shown recently to be the canalicular carrier of organic anions, such as bilirubin and dyes (the canalicular multiple organic anion transporter, or cMOAT).	Bilirubin	109-118	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	184-189
8738722-7	1996	In addition, IL-8 levels were higher in patients who died (p = 0.007), and correlated with biochemical and histological parameters, and severity of liver injury: serum aspartate aminotransferase, alanine aminotransferase, total bilirubin, prothrombin time, indocyanine green retention ratio, tumor necrosis factor-alpha and peripheral neutrophil count in patients with alcoholic hepatitis.	Bilirubin	228-237	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
8903066-10	1996	A third MDR related protein has been shown recently to be the canalicular carrier of organic anions, like bilirubin and dyes (the canalicular Multiple Organic Anion Transporter, or cMOAT).	Bilirubin	106-115	ATP binding cassette subfamily B member 1 L homeolog	Xenopus laevis	8-11
8903066-10	1996	A third MDR related protein has been shown recently to be the canalicular carrier of organic anions, like bilirubin and dyes (the canalicular Multiple Organic Anion Transporter, or cMOAT).	Bilirubin	106-115	ATP binding cassette subfamily C member 2 L homeolog	Xenopus laevis	181-186
8733132-1	1996	Crigler-Najjar syndrome type II (CN-II) is caused by a severely reduced hepatic activity of bilirubin UDP-glucuronosyltransferase (UGT).	Bilirubin	92-101	5'-nucleotidase, cytosolic II	Homo sapiens	33-38
8733132-1	1996	Crigler-Najjar syndrome type II (CN-II) is caused by a severely reduced hepatic activity of bilirubin UDP-glucuronosyltransferase (UGT).	Bilirubin	92-101	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	102-129
8733132-1	1996	Crigler-Najjar syndrome type II (CN-II) is caused by a severely reduced hepatic activity of bilirubin UDP-glucuronosyltransferase (UGT).	Bilirubin	92-101	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	131-134
8758269-4	1996	The serum total bilirubin (TBIL) and liver necrosis of mice increased more markedly by using of TNF alpha, IL-6 or IFN gamma separately with D-GAL (TBIL: 46.2 +/- 10.6 micromol/L, 44.6 +/- 12.9 micromol/L, 41.9 +/- 14.9 micromol/L), then by D-GAL alone (TBIL: 27 +/- 11 micromol/L) also the serum TBIL of mice and liver necrosis also increased after injection of IL-1, IL-6 with D-GAL and TNF alpha.	Bilirubin	16-25	tumor necrosis factor	Mus musculus	96-105
8743107-4	1996	Autoserum regulated IFNg production in a stage-dependent way: it decreased IFNg activity at the bilirubin peak in hepatitis B infection, but not in convalescence.	Bilirubin	96-105	interferon gamma	Homo sapiens	20-24
8743107-4	1996	Autoserum regulated IFNg production in a stage-dependent way: it decreased IFNg activity at the bilirubin peak in hepatitis B infection, but not in convalescence.	Bilirubin	96-105	interferon gamma	Homo sapiens	75-79
8758269-4	1996	The serum total bilirubin (TBIL) and liver necrosis of mice increased more markedly by using of TNF alpha, IL-6 or IFN gamma separately with D-GAL (TBIL: 46.2 +/- 10.6 micromol/L, 44.6 +/- 12.9 micromol/L, 41.9 +/- 14.9 micromol/L), then by D-GAL alone (TBIL: 27 +/- 11 micromol/L) also the serum TBIL of mice and liver necrosis also increased after injection of IL-1, IL-6 with D-GAL and TNF alpha.	Bilirubin	27-31	tumor necrosis factor	Mus musculus	96-105
8758269-4	1996	The serum total bilirubin (TBIL) and liver necrosis of mice increased more markedly by using of TNF alpha, IL-6 or IFN gamma separately with D-GAL (TBIL: 46.2 +/- 10.6 micromol/L, 44.6 +/- 12.9 micromol/L, 41.9 +/- 14.9 micromol/L), then by D-GAL alone (TBIL: 27 +/- 11 micromol/L) also the serum TBIL of mice and liver necrosis also increased after injection of IL-1, IL-6 with D-GAL and TNF alpha.	Bilirubin	27-31	interleukin 6	Mus musculus	107-111
8758269-4	1996	The serum total bilirubin (TBIL) and liver necrosis of mice increased more markedly by using of TNF alpha, IL-6 or IFN gamma separately with D-GAL (TBIL: 46.2 +/- 10.6 micromol/L, 44.6 +/- 12.9 micromol/L, 41.9 +/- 14.9 micromol/L), then by D-GAL alone (TBIL: 27 +/- 11 micromol/L) also the serum TBIL of mice and liver necrosis also increased after injection of IL-1, IL-6 with D-GAL and TNF alpha.	Bilirubin	27-31	interferon gamma	Mus musculus	115-124
8758269-4	1996	The serum total bilirubin (TBIL) and liver necrosis of mice increased more markedly by using of TNF alpha, IL-6 or IFN gamma separately with D-GAL (TBIL: 46.2 +/- 10.6 micromol/L, 44.6 +/- 12.9 micromol/L, 41.9 +/- 14.9 micromol/L), then by D-GAL alone (TBIL: 27 +/- 11 micromol/L) also the serum TBIL of mice and liver necrosis also increased after injection of IL-1, IL-6 with D-GAL and TNF alpha.	Bilirubin	148-152	tumor necrosis factor	Mus musculus	96-105
8758269-4	1996	The serum total bilirubin (TBIL) and liver necrosis of mice increased more markedly by using of TNF alpha, IL-6 or IFN gamma separately with D-GAL (TBIL: 46.2 +/- 10.6 micromol/L, 44.6 +/- 12.9 micromol/L, 41.9 +/- 14.9 micromol/L), then by D-GAL alone (TBIL: 27 +/- 11 micromol/L) also the serum TBIL of mice and liver necrosis also increased after injection of IL-1, IL-6 with D-GAL and TNF alpha.	Bilirubin	148-152	tumor necrosis factor	Mus musculus	96-105
8758269-4	1996	The serum total bilirubin (TBIL) and liver necrosis of mice increased more markedly by using of TNF alpha, IL-6 or IFN gamma separately with D-GAL (TBIL: 46.2 +/- 10.6 micromol/L, 44.6 +/- 12.9 micromol/L, 41.9 +/- 14.9 micromol/L), then by D-GAL alone (TBIL: 27 +/- 11 micromol/L) also the serum TBIL of mice and liver necrosis also increased after injection of IL-1, IL-6 with D-GAL and TNF alpha.	Bilirubin	148-152	tumor necrosis factor	Mus musculus	96-105
8635123-9	1996	In LC patients, serum TGF alpha levels were significantly correlated with serum albumin and total bilirubin levels (r = -0.44 and 0.32, respectively).	Bilirubin	98-107	transforming growth factor alpha	Homo sapiens	22-31
8820424-5	1996	However, the purified UGT1.1r enzyme exhibited glucuronidation activity toward buprenorphine and bilirubin with high efficiency, but the UGT2B1 protein did not react with these compounds.	Bilirubin	97-106	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	22-28
8670060-0	1996	Bilirubin glucuronidation by intact Gunn rat fibroblasts expressing bilirubin UDP-glucuronosyltransferase.	Bilirubin	0-9	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	78-105
8596320-3	1996	A reduced hepatic bilirubin UPD- glucuronosyltransferase (UGT) is associated with this syndrome.	Bilirubin	18-27	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	28-56
8596320-3	1996	A reduced hepatic bilirubin UPD- glucuronosyltransferase (UGT) is associated with this syndrome.	Bilirubin	18-27	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	58-61
8596320-12	1996	INTERPRETATION: In a healthy population there was an association between variation in bilirubin concentration and a mutation within the gene encoding the enzyme bilirubin UGT.	Bilirubin	86-95	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	171-174
8596320-12	1996	INTERPRETATION: In a healthy population there was an association between variation in bilirubin concentration and a mutation within the gene encoding the enzyme bilirubin UGT.	Bilirubin	161-170	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	171-174
8705781-9	1996	There was weaker staining behavior of the extracellular matrix regarding collagen IV and fibronectin in the area of heavy bilirubin impregnation.	Bilirubin	122-131	fibronectin 1	Homo sapiens	89-100
8619894-4	1996	Recent reports of gut transplantation to reverse the metabolic defect in Gunn rats raised further interest in the expression and distribution of human bilirubin (UDP-GTs (HUG Br 1 and HUG Br 2) in the human alimentary tract.	Bilirubin	151-160	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	171-192
8723417-6	1996	In patients with ALD, neutrophil elastase correlated with prothrombin time (r = 0.679, P = 0.001), bilirubin (r = 0.587, P < 0.001), Child-Pugh score (r = 0.546, P < 0.001) and inversely with serum albumin (r = -0.511, P < 0.001).	Bilirubin	99-108	elastase, neutrophil expressed	Homo sapiens	22-41
8591849-5	1996	Maximal serum TGF alpha levels achieved in each case after admission until recovery from disease or death were correlated positively with maximal serum alanine transaminase (ALT) and total bilirubin levels in patients with AH, but negatively with maximal total bilirubin levels in patients with FH.	Bilirubin	189-198	transforming growth factor alpha	Homo sapiens	14-23
8591849-5	1996	Maximal serum TGF alpha levels achieved in each case after admission until recovery from disease or death were correlated positively with maximal serum alanine transaminase (ALT) and total bilirubin levels in patients with AH, but negatively with maximal total bilirubin levels in patients with FH.	Bilirubin	261-270	transforming growth factor alpha	Homo sapiens	14-23
8727697-5	1996	A significant positive correlation between the ALP and Bil values was found, and a statistical difference in these values between the group of colon polyps and the controls and other groups was observed.	Bilirubin	55-58	alkaline phosphatase, placental	Homo sapiens	47-50
8869742-3	1996	Treatment of humans or hepatoma cell lines with drugs such as phenobarbital causes the induction of hepatic bilirubin UGT by increased transcription from the UGT1 gene.	Bilirubin	108-117	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	118-121
8867997-3	1996	UGT activities towards bilirubin, 4-nitrophenol and (-)-morphine were also determined.	Bilirubin	23-32	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	0-3
8635588-1	1996	The effects of 3,3",5 triiodo-L-thyronine (L-T3) on the constitutive levels of hepatic mRNA encoding two UDP-glucuronosyltransferase (UGT) isoforms implicated in the glucuronidation of planar phenolic substrates (UGT1*06) and bilirubin (UGT1*0) were investigated in rat liver.	Bilirubin	226-235	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	134-137
8635588-5	1996	A good relationship observed between UGT activity toward 4-nitrophenol and bilirubin and mRNA levels emphasizes the key role played by the thyroid hormone L-T3 on UGT expression.	Bilirubin	75-84	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	37-40
8635588-5	1996	A good relationship observed between UGT activity toward 4-nitrophenol and bilirubin and mRNA levels emphasizes the key role played by the thyroid hormone L-T3 on UGT expression.	Bilirubin	75-84	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	163-166
8631357-2	1996	Biliverdin IXalpha reductase (BVR) catalyzes the conversion of the heme b degradation product, biliverdin, to bilirubin.	Bilirubin	110-119	biliverdin reductase A	Homo sapiens	0-28
8631357-2	1996	Biliverdin IXalpha reductase (BVR) catalyzes the conversion of the heme b degradation product, biliverdin, to bilirubin.	Bilirubin	110-119	biliverdin reductase A	Homo sapiens	30-33
8869742-3	1996	Treatment of humans or hepatoma cell lines with drugs such as phenobarbital causes the induction of hepatic bilirubin UGT by increased transcription from the UGT1 gene.	Bilirubin	108-117	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	158-162
8869742-4	1996	The upstream region of UGT1*1 (bilirubin UGT) was sequenced and found to contain consensus sequences for several transcriptional regulatory elements including a "BARBIE box".	Bilirubin	31-40	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	23-29
8869742-4	1996	The upstream region of UGT1*1 (bilirubin UGT) was sequenced and found to contain consensus sequences for several transcriptional regulatory elements including a "BARBIE box".	Bilirubin	31-40	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	23-26
8642048-5	1996	In patients with non-neoplastic chronic liver disease, univariate analysis demonstrated a significant correlation between AFP and cholinesterase (R = -0.397, P < 0.001), aspartate aminotransferase (R = 0.421, P < 0.001), bilirubin (R = 0.231, P < 0.05) and cICAM-1 (R = 0.430, P < 0.001).	Bilirubin	227-236	alpha fetoprotein	Homo sapiens	122-125
8672739-7	1996	Of the clinicopathological variables analysed, only serum bilirubin was shown to have an independent influence on CYP protein content.	Bilirubin	58-67	peptidylprolyl isomerase G	Homo sapiens	114-117
8672739-8	1996	Thus, elevated serum bilirubin concentrations were associated with significant declines in the contents of CYP1A2 and CYP2C8/10 but not CYP3A or CYP2E1.	Bilirubin	21-30	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	107-113
8672739-8	1996	Thus, elevated serum bilirubin concentrations were associated with significant declines in the contents of CYP1A2 and CYP2C8/10 but not CYP3A or CYP2E1.	Bilirubin	21-30	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	118-124
8672739-9	1996	The mechanisms for the effects of nutritional status and serum bilirubin concentration on the levels of CYP proteins are unclear, but could be mediated by factors such as cytokines, dietary composition and alterations in the level of serum bile acids.	Bilirubin	63-72	peptidylprolyl isomerase G	Homo sapiens	104-107
8926561-5	1996	We encountered unanticipated difficulties in plasma glucose measurement by the automated hexokinase method caused by the combinations of plasma free hemoglobin, bilirubin, and plasma triglycerides, which are frequently elevated in newborn plasma.	Bilirubin	161-170	hexokinase 1	Homo sapiens	89-99
9275643-3	1996	After injection of TNF alpha with D-Gal, the total bilirubin level in rat blood increased and hepatocyte necrosis appeared (P < 0.05).	Bilirubin	51-60	tumor necrosis factor	Rattus norvegicus	19-28
8825387-7	1996	At P21, Ki of bilirubin was significantly lower than at P10 and ranged from 0.03-0.06 microL/g/min in most brain areas.	Bilirubin	14-23	KRAS proto-oncogene, GTPase	Rattus norvegicus	3-6
8825387-10	1996	At P21, hyperbilirubinemia induced increases in blood-to-brain transfer of bilirubin of 50-200% in 16 brain areas, except in the hippocampus, sensory-motor cortex, and thalamic nuclei where they reached 200-433%.	Bilirubin	13-22	KRAS proto-oncogene, GTPase	Rattus norvegicus	3-6
7503774-7	1995	The magnitude of inhibition was: PSC > CsA > quinidine > vinblastine > verapamil < actinomycin D > colchicine > reserpine > bilirubin > doxorubicin > progesterone.	Bilirubin	148-157	PSC	Homo sapiens	33-36
8554318-2	1995	Among the isozymes expressed in rat hepatic microsomes, UGT1B1 (54 kDa) of bilirubin cluster was found to be a major form and minor forms were identified as UGT1A1 (53 kDa), UGT1B2 (56 kDa), and UGT1B5 (57 kDa).	Bilirubin	75-84	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	157-163
8727943-5	1996	No significant correlations were observed between the plasma levels of HGF and endotoxin (r = 0.02) or beta-glucan (r = -0.05) in any of the patients; however, plasma HGF was significantly correlated with the WBC count (r = 0.34, P < 0.05) and with total bilirubin (r = 0.45, P < 0.01).	Bilirubin	258-267	hepatocyte growth factor	Homo sapiens	167-170
8748689-7	1995	Bosentan treatment of rats undergoing CCl4 inhalation resulted in a significant protection against elevation of ALT, AST, LDH and bilirubin.	Bilirubin	130-139	C-C motif chemokine ligand 4	Rattus norvegicus	38-42
7492328-10	1995	These results suggest that binding of acyl-CoA and acylation of UDPGT isoforms regulate the enzyme activities, implying a possible novel function for fatty acyl-CoA in glucuronidation, which is involved in the metabolism of drugs, steroids and bilirubin.	Bilirubin	244-253	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	64-69
7479784-8	1995	in anesthetized rats resulted in the release of tumor necrosis factor alpha and interferon gamma and MODS, as indicated by a decrease in arterial oxygen pressure (lung) and an increase in plasma concentrations of bilirubin and alanine aminotransferase (liver), creatinine and urea (kidney), lipase (pancreas), and creatine kinase (heart or skeletal muscle).	Bilirubin	213-222	tumor necrosis factor	Rattus norvegicus	48-75
7479784-8	1995	in anesthetized rats resulted in the release of tumor necrosis factor alpha and interferon gamma and MODS, as indicated by a decrease in arterial oxygen pressure (lung) and an increase in plasma concentrations of bilirubin and alanine aminotransferase (liver), creatinine and urea (kidney), lipase (pancreas), and creatine kinase (heart or skeletal muscle).	Bilirubin	213-222	interferon gamma	Rattus norvegicus	80-105
7669030-6	1995	Moreover, feeding with ascorbic acid suppressed the elevation of hepatic mRNA level of heme oxygenase-1, the rate-limiting enzyme of bilirubin biosynthesis, in rats injected with LPS.	Bilirubin	133-142	heme oxygenase 1	Rattus norvegicus	87-103
8903758-10	1995	Indeed, the effects of the dye are quite discrete during moderate hyperbilirubinemia at P21 when no bilirubin is detectable in the brain while they are massive during severe hyperbilirubinemia at P21 and at both levels of intoxication at P10 when bilirubin has entered the brain in measurable amounts.	Bilirubin	71-80	KRAS proto-oncogene, GTPase	Rattus norvegicus	88-91
8903758-10	1995	Indeed, the effects of the dye are quite discrete during moderate hyperbilirubinemia at P21 when no bilirubin is detectable in the brain while they are massive during severe hyperbilirubinemia at P21 and at both levels of intoxication at P10 when bilirubin has entered the brain in measurable amounts.	Bilirubin	100-109	KRAS proto-oncogene, GTPase	Rattus norvegicus	88-91
7560084-0	1995	Influence of glutathione S-transferase B (ligandin) on the intermembrane transfer of bilirubin.	Bilirubin	85-94	glutathione S-transferase alpha 2	Rattus norvegicus	42-50
7675408-6	1995	Both maternal serum titers and AF bilirubin measurements provided early indications that the fetus might have the RhE antigen.	Bilirubin	34-43	factor interacting with PAPOLA and CPSF1	Homo sapiens	114-117
8528206-0	1995	Gilbert"s syndrome is caused by a heterozygous missense mutation in the gene for bilirubin UDP-glucuronosyltransferase.	Bilirubin	81-90	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	91-118
8845801-8	1995	Using the bile containing bilirubin diglucuronide as a substrate, the purified beta-glucuronidase was able to hydrolyze it to bilirubin.	Bilirubin	26-35	glucuronidase beta	Homo sapiens	79-97
8845801-8	1995	Using the bile containing bilirubin diglucuronide as a substrate, the purified beta-glucuronidase was able to hydrolyze it to bilirubin.	Bilirubin	126-135	glucuronidase beta	Homo sapiens	79-97
7478807-7	1995	In CD+CCl4 treatment, ALT, SDH, and bilirubin levels peaked between 36 and 48 h after CCl4.	Bilirubin	36-45	C-C motif chemokine ligand 4	Rattus norvegicus	6-10
7646470-9	1995	By analogy with other proteins containing these cysteine-rich repeats, it is possible that, in gall-bladder mucin, this domain serves as a binding site for hydrophobic ligands such as bilirubin, cholesterol and other biliary lipids.	Bilirubin	184-193	deleted in malignant brain tumors 1 protein	Bos taurus	95-113
8528206-1	1995	Gilbert"s syndrome, which is characterized by chronic, non-hemolytic unconjugated hyperbilirubinemia, is caused by a reduction in the activity of hepatic bilirubin UDP-glucuronosyltransferase (UGT).	Bilirubin	87-96	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	164-191
7581080-2	1995	The median bilirubin on day 15 after transplant and the maximum bilirubin in the first 100 days were significantly higher in 155 patients with ABO-mismatched donors compared with 322 patients with ABO-matched donors.	Bilirubin	11-20	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	143-146
7472937-11	1995	Treatment with CCK appears to be associated with a decline in direct bilirubin levels, provided overt liver failure has not developed.	Bilirubin	69-78	cholecystokinin	Homo sapiens	15-18
7481528-6	1995	The IgA output correlated with neither swallowed saliva (as indicated by amylase in the gastric perfusate) nor duodenogastric reflux (as indicated by gastric occurrence of bilirubin and/or duodenally infused PEG4000).	Bilirubin	172-181	CD79a molecule	Homo sapiens	4-7
7581080-2	1995	The median bilirubin on day 15 after transplant and the maximum bilirubin in the first 100 days were significantly higher in 155 patients with ABO-mismatched donors compared with 322 patients with ABO-matched donors.	Bilirubin	64-73	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	143-146
7603447-0	1995	Cloning and stable expression of a cDNA encoding a rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 1.1) that catalyzes the glucuronidation of opioids and bilirubin.	Bilirubin	173-182	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	61-88
7674843-5	1995	In 32 patients with cholestasis, plasma Hex was increased compared to controls, and correlated to bilirubin.	Bilirubin	98-107	O-GlcNAcase	Homo sapiens	40-43
7674843-8	1995	The impact of biliary obstruction on plasma Hex is further illustrated by the observation that decompression lowered plasma Hex as well as bilirubin and alkaline phosphatase.	Bilirubin	139-148	O-GlcNAcase	Homo sapiens	44-47
7603447-0	1995	Cloning and stable expression of a cDNA encoding a rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 1.1) that catalyzes the glucuronidation of opioids and bilirubin.	Bilirubin	173-182	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	90-121
7603447-6	1995	The deduced amino acid sequence of pM1 contains amino acid sequences identical to the amino-terminal and internal peptides of the purified rat liver opioid UGT and to sequences reported for a rat liver bilirubin UGT [FEBS Lett.	Bilirubin	202-211	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	212-215
7603447-9	1995	Expressed UGT1.1r protein catalyzed the glucuronidation of buprenorphine and bilirubin at high rates.	Bilirubin	77-86	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	10-16
7603447-11	1995	These results show that bilirubin and opioids can be conjugated by the same rat liver UGT.	Bilirubin	24-33	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	86-89
7625926-0	1995	Kinetic analysis of UDP-glucuronosyltransferase in bilirubin conjugation by encapsulated hepatocytes for transplantation into Gunn rats.	Bilirubin	51-60	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	20-47
7634181-7	1995	In malignant jaundice, elevated serum bilirubin levels were correlated with CA125 (r = 0.34, p < 0.05) but not with CA19-9 levels.	Bilirubin	38-47	mucin 16, cell surface associated	Homo sapiens	76-81
7634181-8	1995	In benign jaundice, serum bilirubin were correlated with CA19-9 (r = 0.58, p < 0.001) and CA125 (r = 0.45, p < 0.01) levels.	Bilirubin	26-35	mucin 16, cell surface associated	Homo sapiens	93-98
7625926-1	1995	Kinetic analysis of the enzyme UDP-glucuronosyltransferase (UDPGT), responsible for the conjugation of bilirubin, suggests that it is a multisubunit enzyme in which there is cooperative binding of the substrate to the subunits.	Bilirubin	103-112	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	31-58
7625926-1	1995	Kinetic analysis of the enzyme UDP-glucuronosyltransferase (UDPGT), responsible for the conjugation of bilirubin, suggests that it is a multisubunit enzyme in which there is cooperative binding of the substrate to the subunits.	Bilirubin	103-112	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	60-65
7625926-2	1995	The binding of bilirubin to UDPGT shows positive cooperativity with an apparent Hill coefficient of 2.9.	Bilirubin	15-24	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	28-33
7768081-6	1995	RESULTS: Combined lipo-PGE1/glucagon-insulin therapy can prevent the elevation of serum ALT level and total bilirubin level after Lipiodol-targeted chemotherapy.	Bilirubin	108-117	insulin	Homo sapiens	37-44
7663413-1	1995	The binding of some cephalosporins to human serum albumin was studied using probes for the so-called I, II, bilirubin and fatty acids binding sites.	Bilirubin	108-117	albumin	Homo sapiens	44-57
7677729-1	1995	The mouse gene for phenol UDP-glucuronosyltransferase (UDPGT; Ugtla1) was mapped at 42 cM on chromosome 1, a position identical to that of the gene for bilirubin UDPGT (Ugtla1), from linkage analysis of a three-point cross test with Idh-1, En-1, and Ugtla1 as marker genes.	Bilirubin	152-161	UDP glucuronosyltransferase 1 family, polypeptide A6A	Mus musculus	19-53
7715297-0	1995	Analysis of genes for bilirubin UDP-glucuronosyltransferase in Gilbert"s syndrome.	Bilirubin	22-31	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	32-59
7677729-1	1995	The mouse gene for phenol UDP-glucuronosyltransferase (UDPGT; Ugtla1) was mapped at 42 cM on chromosome 1, a position identical to that of the gene for bilirubin UDPGT (Ugtla1), from linkage analysis of a three-point cross test with Idh-1, En-1, and Ugtla1 as marker genes.	Bilirubin	152-161	UDP glucuronosyltransferase 1 family, polypeptide A6A	Mus musculus	55-60
7677729-1	1995	The mouse gene for phenol UDP-glucuronosyltransferase (UDPGT; Ugtla1) was mapped at 42 cM on chromosome 1, a position identical to that of the gene for bilirubin UDPGT (Ugtla1), from linkage analysis of a three-point cross test with Idh-1, En-1, and Ugtla1 as marker genes.	Bilirubin	152-161	UDP glucuronosyltransferase 1 family, polypeptide A6A	Mus musculus	162-167
7677729-1	1995	The mouse gene for phenol UDP-glucuronosyltransferase (UDPGT; Ugtla1) was mapped at 42 cM on chromosome 1, a position identical to that of the gene for bilirubin UDPGT (Ugtla1), from linkage analysis of a three-point cross test with Idh-1, En-1, and Ugtla1 as marker genes.	Bilirubin	152-161	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	233-238
7677729-1	1995	The mouse gene for phenol UDP-glucuronosyltransferase (UDPGT; Ugtla1) was mapped at 42 cM on chromosome 1, a position identical to that of the gene for bilirubin UDPGT (Ugtla1), from linkage analysis of a three-point cross test with Idh-1, En-1, and Ugtla1 as marker genes.	Bilirubin	152-161	engrailed 1	Mus musculus	240-244
7628292-2	1995	A full-length cDNA-encoding human UGT1.4 (the so-called "minor" human bilirubin UGT) was inserted into the expression vector pREP9 and transfected into human embryonic kidney 293 cells, and stable transfectants were obtained after geneticin selection.	Bilirubin	70-79	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	34-40
7789015-0	1995	Recombinant human erythropoietin (r-HuEPO) increases total bilirubin production in premature infants.	Bilirubin	59-68	erythropoietin	Homo sapiens	18-32
8530225-6	1995	The results of the present study suggest that both calcium bilirubinate stones and periampullary duodenal diverticula are contributing factors in the development of RCS in patients with common bile duct stones, and that end-to-side choledocho-jejunostomy should be considered for patients with these two factors after the initial common duct exploration.	Bilirubin	51-71	cAMP regulated phosphoprotein 21	Homo sapiens	165-168
7536200-7	1995	IGFBP-3 correlated significantly with the wedged hepatic venous pressure (r = -0.49; P < 0.05), serum aspartate aminotransferase (r = -0.66; P < 0.01), serum bilirubin (r = -0.65; P < 0.01), serum albumin (r = 0.64; P < 0.01), and the Child score (r = -0.57; P < 0.01).	Bilirubin	164-173	insulin like growth factor binding protein 3	Homo sapiens	0-7
7716765-7	1995	The Gunn rats, which present a genetic defect in the bilirubin UGT isoforms, were able to glucuronidate the drug as well as the congenic strain.	Bilirubin	53-62	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	63-66
7866987-6	1995	These rats have a hereditary homozygous deficiency in bilirubin UGT and demonstrate reduced xenobiotic glucuronidation, enhanced cytochrome P-450-catalyzed bioactivation, covalent binding, and toxicity of acetaminophen and B(a)P. Control fibroblasts were cultured from UGT-normal congenic homozygous male RHA-(+/+) rats and male Wistar rats.	Bilirubin	54-63	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	64-67
7628292-2	1995	A full-length cDNA-encoding human UGT1.4 (the so-called "minor" human bilirubin UGT) was inserted into the expression vector pREP9 and transfected into human embryonic kidney 293 cells, and stable transfectants were obtained after geneticin selection.	Bilirubin	70-79	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	34-37
7852413-3	1995	267, 3257-3261) of the single-copy UGT1 gene complex locus encoding both bilirubin and phenol UDP-glucuronosyltransferases (transferase) has been critical to the determination of genetic defects in Crigler-Najjar patients.	Bilirubin	73-82	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	35-39
7875682-12	1995	These conditionally immortalized cells will be useful for ex vivo evaluation of bilirubin-UGT gene transfer vectors.	Bilirubin	80-89	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	90-93
8655255-5	1995	vWf was also increased in other liver diseases (249.9 +/- 1.7%; p<0.001) and related to bilirubin (r = 0.59, p<0.05).	Bilirubin	91-100	von Willebrand factor	Homo sapiens	0-3
7852413-4	1995	The complex (UGT1A-UGT1M) codes for at least two bilirubin, three bilirubin-like, and eight phenol transferase isozymes.	Bilirubin	49-58	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	13-24
7852413-4	1995	The complex (UGT1A-UGT1M) codes for at least two bilirubin, three bilirubin-like, and eight phenol transferase isozymes.	Bilirubin	66-75	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	13-24
7852413-8	1995	Recessively inherited mutant alleles for the predominant bilirubin isozyme, the HUG-Br1 protein, substituted Arg for Gly at codon 276 (G276R) in exon 1 of UGT1A abolishing a conserved di-glycine.	Bilirubin	57-66	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	80-87
7852413-8	1995	Recessively inherited mutant alleles for the predominant bilirubin isozyme, the HUG-Br1 protein, substituted Arg for Gly at codon 276 (G276R) in exon 1 of UGT1A abolishing a conserved di-glycine.	Bilirubin	57-66	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	155-160
7864646-4	1995	In addition, the 34-kDa GSTP1-1 binds a number of hydrophobic compounds such as 1-chloro-2,4-dinitrobenzene, hemin, and bilirubin with the same affinity of the native enzyme.	Bilirubin	120-129	glutathione S-transferase pi 1	Homo sapiens	24-31
7817994-9	1995	In phase 2, UDPGT activity was quantitated at 0, 2, 4, and 8 weeks using known quantities of bilirubin as substrate.	Bilirubin	93-102	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	12-17
7840202-4	1995	The chloride-sensitive portion of BSP uptake was inhibited by bilirubin (10 microM; 27%), 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (100 microM; 57%), bumetanide (100 microM; 48%), taurocholate (200 microM; 51%), and cholate (200 microM; 45%).	Bilirubin	62-71	integrin-binding sialoprotein	Rattus norvegicus	34-37
7817994-19	1995	Wistar rat UDPGT activity in intestine and liver averaged 0.61 +/- 0.05 and 1.88 +/- 0.06 mg bilirubin conjugated/mg tissue per hour, respectively.	Bilirubin	93-102	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	11-16
8744687-2	1995	Interferon (IFN) induction in leukocytes of cows with fatty liver, elevated ketone bodies, free fatty acids, bilirubin concentration and high aspartate aminotransferase (AST) activity, revealed impaired IFN production which was not improved by using known immunomodulators such as isoprinosine, levamisole, TFX and lactoferrin.	Bilirubin	109-118	interferon alpha-H	Bos taurus	0-10
8750143-7	1995	The incidence of bilirubin elevations, weight gain > 5% and veno-occlusive disease (VOD) was lower in patients receiving the "anti-TNF" therapy.	Bilirubin	17-26	tumor necrosis factor	Homo sapiens	134-137
8744687-2	1995	Interferon (IFN) induction in leukocytes of cows with fatty liver, elevated ketone bodies, free fatty acids, bilirubin concentration and high aspartate aminotransferase (AST) activity, revealed impaired IFN production which was not improved by using known immunomodulators such as isoprinosine, levamisole, TFX and lactoferrin.	Bilirubin	109-118	interferon alpha-H	Bos taurus	12-15
7698007-0	1995	Mapping of rat bilirubin UDP-glucuronosyl-transferase gene (Ugt1a1) to chromosome region 9q35-->q36.	Bilirubin	15-24	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	60-66
7850304-6	1995	RESULTS: The urinary beta-glucuronidase activity was affected by certain inhibitors (D-glucaro-1, 4-lactone), intrinsic substrates (conjugated bilirubin) and bacterial beta-glucuronidase present in the urine.	Bilirubin	143-152	glucuronidase beta	Homo sapiens	21-39
7850304-8	1995	When those urine samples which were contaminated with bacteria and/or bilirubin were excluded, the beta-glucuronidase concentration (X ng/mumol creatinine) was significantly correlated with its maximal velocity (Y nmol/min/mumol creatinine): Y = 0.003 + 0.103X.	Bilirubin	70-79	glucuronidase beta	Homo sapiens	99-117
7698007-1	1995	Bilirubin and phenol UDP-glucuronosyltransferases (UGTs) are located on the same chromosome and comprise the UGT1 gene complex.	Bilirubin	0-9	UDP glucuronosyltransferase 1 family, polypeptide A2	Rattus norvegicus	109-113
7698007-2	1995	A 1,763-bp cDNA probe (UGT1*0) specific for rat liver bilirubin UGT was used to localize the UGT1 complex locus (Ugt1a1) to chromosome region 9q35-->q36 by fluorescence in situ hybridization.	Bilirubin	54-63	UDP glucuronosyltransferase 1 family, polypeptide A2	Rattus norvegicus	23-29
7698007-2	1995	A 1,763-bp cDNA probe (UGT1*0) specific for rat liver bilirubin UGT was used to localize the UGT1 complex locus (Ugt1a1) to chromosome region 9q35-->q36 by fluorescence in situ hybridization.	Bilirubin	54-63	UDP glucuronosyltransferase 1 family, polypeptide A2	Rattus norvegicus	23-27
7698007-2	1995	A 1,763-bp cDNA probe (UGT1*0) specific for rat liver bilirubin UGT was used to localize the UGT1 complex locus (Ugt1a1) to chromosome region 9q35-->q36 by fluorescence in situ hybridization.	Bilirubin	54-63	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	113-119
7698078-4	1994	UGT-HP3 (bilirubin UGT) catalyzed the glucuronidation of ethinylestradiol.	Bilirubin	9-18	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	0-3
7528117-9	1995	Adding bilirubin (10 to 11 mg/dL [171 to 188.1 mumol/L]), increased the methemoglobin reading by 0.23%, increased the oxyhemoglobin reading by 0.45%, and increased total hemoglobin by 0.21 g/dL.	Bilirubin	7-16	hemoglobin subunit gamma 2	Homo sapiens	72-85
7989595-11	1994	The affinities for bilirubin of B-UGT1 expressed in COS cells and B-UGT from human liver microsomes were similar with Km of 5.1 +/- 0.9 microM and 7.9 +/- 5.3 microM, respectively.	Bilirubin	19-28	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	34-38
7989595-12	1994	B-UGT1 from patient B had a tenfold decreased affinity for bilirubin, Km = 56 +/- 23 microM.	Bilirubin	59-68	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	2-6
8529712-7	1995	These data suggest that bilirubin interferes with surfactant proteins SP-B and/or SP-C, thus impairing surfactant activity at the air-liquid interface.	Bilirubin	24-33	surfactant protein B	Rattus norvegicus	70-74
8529712-7	1995	These data suggest that bilirubin interferes with surfactant proteins SP-B and/or SP-C, thus impairing surfactant activity at the air-liquid interface.	Bilirubin	24-33	surfactant protein C	Rattus norvegicus	82-86
7806142-5	1995	Serum HGF levels in these diseases were significantly increased compared with those in the controls (P < .001), and exhibited a positive correlation with total bilirubin, indocyanine green (ICG) test (R15), asparate aminotransferase (AST), and a negative correlation with albumin and prothrombin time (P < .001).	Bilirubin	163-172	hepatocyte growth factor	Homo sapiens	6-9
7874270-5	1994	Significant correlations were found between u-PA plasma levels and the results of seven different liver function tests in three groups without associated HCC; u-PA antigen and prothrombin time (%), hepaplastin test (%), serum cholinesterase, serum albumin, serum total cholesterol, and indocyanine green clearance correlated negatively, while u-PA antigen and serum total bilirubin correlated positively.	Bilirubin	372-381	plasminogen activator, urokinase	Homo sapiens	44-48
7698078-4	1994	UGT-HP3 (bilirubin UGT) catalyzed the glucuronidation of ethinylestradiol.	Bilirubin	9-18	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	19-22
7929359-7	1994	A multistep protocol developed for isolation of HO-2 resulted in a homogeneous protein with a specific activity up to 6,500 nmol of bilirubin/mg/h.	Bilirubin	132-141	heme oxygenase 2	Homo sapiens	48-52
7945246-9	1994	analysis of the regioselective glucuronidation of beta-oestradiol (E2) demonstrated that it was conjugated solely at its A-ring hydroxy group by the bilirubin UGT to form E2-3-glucuronide, this was in contrast with human liver microsomes which formed 3- and 17-glucuronides of this oestrogen.	Bilirubin	149-158	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	159-162
7945246-10	1994	Studies utilizing microsomes from a Crigler-Najjar patient and inhibition of E2 glucuronidation with bilirubin indicated that the cloned expressed bilirubin UGT was the major human UGT isoform responsible for the formation of E2-3-glucuronide, which is the predominant E2 conjugate in human urine.	Bilirubin	101-110	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	157-160
7945246-10	1994	Studies utilizing microsomes from a Crigler-Najjar patient and inhibition of E2 glucuronidation with bilirubin indicated that the cloned expressed bilirubin UGT was the major human UGT isoform responsible for the formation of E2-3-glucuronide, which is the predominant E2 conjugate in human urine.	Bilirubin	147-156	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	157-160
7945246-10	1994	Studies utilizing microsomes from a Crigler-Najjar patient and inhibition of E2 glucuronidation with bilirubin indicated that the cloned expressed bilirubin UGT was the major human UGT isoform responsible for the formation of E2-3-glucuronide, which is the predominant E2 conjugate in human urine.	Bilirubin	147-156	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	181-184
7814798-5	1994	In cirrhosis, levels of macrophage colony stimulating factor correlated positively with the serum alanine aminotransferase levels (p < 0.05), total bilirubin levels (p < 0.05), and indocyanine green clearance (p < 0.05).	Bilirubin	151-160	colony stimulating factor 1	Homo sapiens	24-60
7525927-2	1994	Heme oxygenase (HO) isozymes, HO-1 (HSP32) and HO-2, catalyze the rate limiting step in the only known pathway in eukaryotes for the generation of the potential cellular message, carbon monoxide, and the antioxidant, bilirubin.	Bilirubin	217-226	heme oxygenase 1	Homo sapiens	30-34
7525927-2	1994	Heme oxygenase (HO) isozymes, HO-1 (HSP32) and HO-2, catalyze the rate limiting step in the only known pathway in eukaryotes for the generation of the potential cellular message, carbon monoxide, and the antioxidant, bilirubin.	Bilirubin	217-226	heme oxygenase 1	Homo sapiens	36-41
7525927-2	1994	Heme oxygenase (HO) isozymes, HO-1 (HSP32) and HO-2, catalyze the rate limiting step in the only known pathway in eukaryotes for the generation of the potential cellular message, carbon monoxide, and the antioxidant, bilirubin.	Bilirubin	217-226	heme oxygenase 2	Homo sapiens	47-51
7831384-5	1994	A decrease in the binding constant of bilirubin to Sn-mesoporphyrin-mediated photosensitized human serum albumin (HSA) was observed following illumination at 50 W/m2 in the spectral range of 520-700 nm; there were 2.0 +/- 0.2 bilirubins bound per HSA for samples illuminated < 120 min; following 180 min illumination, the stoichiometry decreased to 1.5 +/- 0.1 bilirubin per HSA.	Bilirubin	38-47	albumin	Homo sapiens	99-118
7831384-5	1994	A decrease in the binding constant of bilirubin to Sn-mesoporphyrin-mediated photosensitized human serum albumin (HSA) was observed following illumination at 50 W/m2 in the spectral range of 520-700 nm; there were 2.0 +/- 0.2 bilirubins bound per HSA for samples illuminated < 120 min; following 180 min illumination, the stoichiometry decreased to 1.5 +/- 0.1 bilirubin per HSA.	Bilirubin	38-47	albumin	Homo sapiens	114-117
7831384-5	1994	A decrease in the binding constant of bilirubin to Sn-mesoporphyrin-mediated photosensitized human serum albumin (HSA) was observed following illumination at 50 W/m2 in the spectral range of 520-700 nm; there were 2.0 +/- 0.2 bilirubins bound per HSA for samples illuminated < 120 min; following 180 min illumination, the stoichiometry decreased to 1.5 +/- 0.1 bilirubin per HSA.	Bilirubin	38-47	albumin	Homo sapiens	247-250
7831384-5	1994	A decrease in the binding constant of bilirubin to Sn-mesoporphyrin-mediated photosensitized human serum albumin (HSA) was observed following illumination at 50 W/m2 in the spectral range of 520-700 nm; there were 2.0 +/- 0.2 bilirubins bound per HSA for samples illuminated < 120 min; following 180 min illumination, the stoichiometry decreased to 1.5 +/- 0.1 bilirubin per HSA.	Bilirubin	226-236	albumin	Homo sapiens	99-118
7931884-5	1994	Cocaine was a weak inducer of GST but a strong inducer of KSI, a member of the GST family of enzymes that is closely associated with bilirubin transport (ligandin) in liver, and a moderately strong inducer of BGT.	Bilirubin	133-142	glutathione S-transferase kappa 1	Homo sapiens	79-82
7831384-5	1994	A decrease in the binding constant of bilirubin to Sn-mesoporphyrin-mediated photosensitized human serum albumin (HSA) was observed following illumination at 50 W/m2 in the spectral range of 520-700 nm; there were 2.0 +/- 0.2 bilirubins bound per HSA for samples illuminated < 120 min; following 180 min illumination, the stoichiometry decreased to 1.5 +/- 0.1 bilirubin per HSA.	Bilirubin	226-236	albumin	Homo sapiens	114-117
7831384-5	1994	A decrease in the binding constant of bilirubin to Sn-mesoporphyrin-mediated photosensitized human serum albumin (HSA) was observed following illumination at 50 W/m2 in the spectral range of 520-700 nm; there were 2.0 +/- 0.2 bilirubins bound per HSA for samples illuminated < 120 min; following 180 min illumination, the stoichiometry decreased to 1.5 +/- 0.1 bilirubin per HSA.	Bilirubin	226-235	albumin	Homo sapiens	99-118
7831384-5	1994	A decrease in the binding constant of bilirubin to Sn-mesoporphyrin-mediated photosensitized human serum albumin (HSA) was observed following illumination at 50 W/m2 in the spectral range of 520-700 nm; there were 2.0 +/- 0.2 bilirubins bound per HSA for samples illuminated < 120 min; following 180 min illumination, the stoichiometry decreased to 1.5 +/- 0.1 bilirubin per HSA.	Bilirubin	226-235	albumin	Homo sapiens	114-117
7712914-3	1994	There was significant correlation between tumor necrosis factor alpha levels and ALT elevation and also between TNF alpha levels and bilirubin contents more than 100 mumol/L in chronic hepatitis patients.	Bilirubin	133-142	tumor necrosis factor	Homo sapiens	112-121
7994560-5	1994	Serum HGF values in acute hepatitis were significantly correlated with serum bilirubin and gamma-GTP levels, whereas those in acute hepatic failure were not.	Bilirubin	77-86	hepatocyte growth factor	Homo sapiens	6-9
8027054-1	1994	Crigler-Najjar syndrome type I (CN-I) is caused by an inherited absence of UDP-glucuronosyltransferase activity toward bilirubin (B-UGT), resulting in severe non-hemolytic unconjugated hyperbilirubinemia.	Bilirubin	119-128	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	132-135
8048075-3	1994	We have shown previously in vivo and in hepatic microsomes that rats with a hereditary deficiency in bilirubin UGT (Gunn and RHA strains) have decreased glucuronidation of BP metabolites and enhanced BP covalent binding to hepatic DNA and microsomal protein, and enhanced BP embryotoxicity.	Bilirubin	101-110	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	111-114
8048075-8	1994	In vivo, bilirubin glucuronidation was reduced in UGT deficiency, with progressively higher plasma concentrations of unconjugated bilirubin in j/+ and j/j UGT-deficient rats compared to +/+ UGT-normal controls (p < 0.05).	Bilirubin	9-18	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	50-53
8048075-8	1994	In vivo, bilirubin glucuronidation was reduced in UGT deficiency, with progressively higher plasma concentrations of unconjugated bilirubin in j/+ and j/j UGT-deficient rats compared to +/+ UGT-normal controls (p < 0.05).	Bilirubin	9-18	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	155-158
8027054-1	1994	Crigler-Najjar syndrome type I (CN-I) is caused by an inherited absence of UDP-glucuronosyltransferase activity toward bilirubin (B-UGT), resulting in severe non-hemolytic unconjugated hyperbilirubinemia.	Bilirubin	119-128	5'-nucleotidase, cytosolic IA	Homo sapiens	32-36
8027054-2	1994	Based on the expression of cDNAs in COS cells, two UGT isoforms in human liver, B-UGT1 and B-UGT2, have been reported to catalyze bilirubin glucuronidation.	Bilirubin	130-139	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	51-54
8027054-2	1994	Based on the expression of cDNAs in COS cells, two UGT isoforms in human liver, B-UGT1 and B-UGT2, have been reported to catalyze bilirubin glucuronidation.	Bilirubin	130-139	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	82-86
8027054-6	1994	If both B-UGT isoforms contribute significantly to bilirubin glucuronidation, a mutation in one of these unique 5" exons should affect a single isoform, while the other isoforms should provide residual B-UGT activity.	Bilirubin	51-60	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	10-13
8027054-11	1994	Together, the results indicate that B-UGT1 is the only physiologically relevant isoform in bilirubin glucuronidation.	Bilirubin	91-100	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	38-42
7716932-3	1994	The correlations calculated between TNF-alpha and Il-6 concentrations calculated between TNF-alpha and Il-6 concentrations and laboratory parameters (laboratory indicators of hepatitis activity--AlAT; liver function indicators--prothrombin index, bilirubin concentration, bile acid concentration, alkaline phosphatase activity, anti-pyrin half-life) were non-significant in Spearman non-parametric test (p > 0.005) except for the correlation between albumin and TNF-alpha concentrations.	Bilirubin	247-256	interleukin 6	Homo sapiens	50-54
7936809-0	1994	A new type of defect in the gene for bilirubin uridine 5"-diphosphate-glucuronosyltransferase in a patient with Crigler-Najjar syndrome type I. Crigler-Najjar syndrome (CN) type I, which is characterized by the complete absence of bilirubin uridine 5"-diphosphate-glucuronosyltransferase (UGT) activity, is inherited as an autosomal recessive trait associated with unconjugated hyperbilirubinemia.	Bilirubin	37-46	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	289-292
7525431-6	1994	A negative correlation was found between absolute numbers of CD8+ T cells and total serum bilirubin levels (r = -0.50, p < 0.05).	Bilirubin	90-99	CD8a molecule	Homo sapiens	61-64
7959542-5	1994	IL-6-M correlated significantly with the maximum concentration of total bilirubin and with the postoperative decrease in AKBR.	Bilirubin	72-81	interleukin 6	Homo sapiens	0-4
7936809-2	1994	Recently, cDNA for two human liver bilirubin UGT (UGT1A and UGT1D) were isolated, and their genetic organization was determined.	Bilirubin	35-44	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	45-48
7936809-2	1994	Recently, cDNA for two human liver bilirubin UGT (UGT1A and UGT1D) were isolated, and their genetic organization was determined.	Bilirubin	35-44	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	50-55
7936809-2	1994	Recently, cDNA for two human liver bilirubin UGT (UGT1A and UGT1D) were isolated, and their genetic organization was determined.	Bilirubin	35-44	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	60-65
7936809-5	1994	We describe here a new type of defect in the gene for bilirubin UGT in a patient with CN type I, namely, an abnormality in the exon 1 that is characteristic of the UGT1A gene.	Bilirubin	54-63	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	64-67
7936809-5	1994	We describe here a new type of defect in the gene for bilirubin UGT in a patient with CN type I, namely, an abnormality in the exon 1 that is characteristic of the UGT1A gene.	Bilirubin	54-63	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	164-169
7515265-9	1994	Factors associated with G-CSF elevation were fever, neutropenia, pathogen type and raised bilirubin and creatinine.	Bilirubin	90-99	colony stimulating factor 3	Homo sapiens	24-29
8155694-0	1994	Involvement of lysine residues of goat serum albumin in high-affinity binding of bilirubin.	Bilirubin	81-90	albumin	Homo sapiens	45-52
8155694-5	1994	About 88% reduction in bilirubin binding was observed after modification of 98% amino groups of serum albumin as studied by visible difference spectroscopy at pH 8.0, and at 0.15 ionic strength.	Bilirubin	23-32	albumin	Homo sapiens	102-109
8155694-7	1994	These results prove the involvement of lysine residues in bilirubin-albumin interaction.	Bilirubin	58-67	albumin	Homo sapiens	68-75
8169606-0	1994	Impact of K2PtCl4 on the structure of human serum albumin and its binding ability of heme and bilirubin.	Bilirubin	94-103	albumin	Homo sapiens	50-57
7913103-8	1994	Intoxication with CCl4 increased (P < 0.05) serum activities of alkaline phosphatase, gamma-GTP and ALT, and bilirubin concentration; liver collagen and lipoperoxidation were also increased.	Bilirubin	112-121	C-C motif chemokine ligand 4	Rattus norvegicus	18-22
8265323-7	1994	CONCLUSIONS: These results suggest that measuring UBC may help in evaluating the possible risk of bilirubin encephalopathy in full-term newborns when there is vigintiphobia (fear of 20).	Bilirubin	98-107	ubiquitin C	Homo sapiens	50-53
7906695-1	1994	Accumulating evidence indicates that mutations in the human UGT1 gene locus abolish hepatic bilirubin UDP-glucuronosyltransferase activity and cause the subsequent accumulation of bilirubin to toxic levels in patients with Crigler-Najjar type 1 (CN-I).	Bilirubin	92-101	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	60-64
7516359-6	1994	Injection of ATP, at -1, +1, 3 and 5 h of CCl4 administration to chlordecone pretreated rats decreased plasma enzyme elevations (alanine and aspartate aminotransferase, sorbitol dehydrogenase) as well as substantially preventing elevation of plasma bilirubin levels at 6, 12 and 24 h. Hepatic ATP levels were also elevated at 6 and 12 h, but not at 24 h.(ABSTRACT TRUNCATED AT 250 WORDS)	Bilirubin	249-258	C-C motif chemokine ligand 4	Rattus norvegicus	42-46
8155087-9	1994	Within both the liver disease and PBC patient groups there were significant negative correlations between Lp(a) levels and bilirubin (R = -0.564, P < 0.001 and R = -0.395, P = 0.010 respectively).	Bilirubin	123-132	lipoprotein(a)	Homo sapiens	106-111
8124862-5	1993	Bilirubin concentrations higher than 376 mumol/L for apo AI and 444 mumol/L for apo B, produce a negative interference.	Bilirubin	0-9	apolipoprotein A1	Homo sapiens	53-59
8280139-2	1993	Two bilirubin UGT isozymes, UGT1A and UGT1D, have been identified.	Bilirubin	4-13	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	14-17
8280139-2	1993	Two bilirubin UGT isozymes, UGT1A and UGT1D, have been identified.	Bilirubin	4-13	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	28-33
8280139-2	1993	Two bilirubin UGT isozymes, UGT1A and UGT1D, have been identified.	Bilirubin	4-13	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	38-43
8280139-3	1993	We analyzed the DNA sequence of the bilirubin UGT genes in a 5-year-old Japanese male patient with CN type II, who had consanguineous parents.	Bilirubin	36-45	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	46-49
8226884-4	1993	The complex (UGT1A-UGT1G) codes for at least two bilirubin, three bilirubin-like, and two phenol transferases.	Bilirubin	49-58	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	13-18
8226839-4	1993	We utilized two unique congenic strains of mice to characterize the role of hepatic beta-glucuronidase in the metabolism and disposition of bilirubin-IX alpha; the first exhibited less than 1% of total hepatic beta-glucuronidase activity (ATM), the second lacked only the microsomal enzyme activity (AT1).	Bilirubin	140-149	glucuronidase, beta	Mus musculus	84-102
8226884-0	1993	A phenylalanine codon deletion at the UGT1 gene complex locus of a Crigler-Najjar type I patient generates a pH-sensitive bilirubin UDP-glucuronosyltransferase.	Bilirubin	122-131	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	38-42
8226884-4	1993	The complex (UGT1A-UGT1G) codes for at least two bilirubin, three bilirubin-like, and two phenol transferases.	Bilirubin	49-58	UDP glucuronosyltransferase family 1 member A7	Homo sapiens	19-24
8226884-3	1993	267, 3257-3261) of the single-copy UGT1 gene complex encoding both bilirubin and phenol UDP-glucuronosyltransferases (transferase) has been critical to the determination of genetic defects in Crigler-Najjar Type I patients.	Bilirubin	67-76	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	35-39
8226839-8	1993	Collectively, these data demonstrate that microsomal beta-glucuronidase modulates the net rate of bilirubin-IX alpha glucuronidation and glucuronide excretion in bile, under both basal and hyperbilirubinemic conditions, and that lysosomal beta-glucuronidase has no such effects.	Bilirubin	98-107	glucuronidase, beta	Mus musculus	53-71
8226839-8	1993	Collectively, these data demonstrate that microsomal beta-glucuronidase modulates the net rate of bilirubin-IX alpha glucuronidation and glucuronide excretion in bile, under both basal and hyperbilirubinemic conditions, and that lysosomal beta-glucuronidase has no such effects.	Bilirubin	98-107	glucuronidase, beta	Mus musculus	239-257
8226884-4	1993	The complex (UGT1A-UGT1G) codes for at least two bilirubin, three bilirubin-like, and two phenol transferases.	Bilirubin	66-75	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	13-18
8226884-4	1993	The complex (UGT1A-UGT1G) codes for at least two bilirubin, three bilirubin-like, and two phenol transferases.	Bilirubin	66-75	UDP glucuronosyltransferase family 1 member A7	Homo sapiens	19-24
8226884-8	1993	The code for the predominant bilirubin isozyme, the HUG-Br1 protein, is missing the phenylalanine codon at position 170 in exon 1 of UGT1A, abolishing a conserved diphenylalanine.	Bilirubin	29-38	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	52-59
8226884-8	1993	The code for the predominant bilirubin isozyme, the HUG-Br1 protein, is missing the phenylalanine codon at position 170 in exon 1 of UGT1A, abolishing a conserved diphenylalanine.	Bilirubin	29-38	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	133-138
8226884-9	1993	We demonstrate that, at the pH (7.6) routinely used for bilirubin glucuronidation studies, both the HUG-Br1 protein and human liver microsomes have approximately one-third the activity seen at the major pH optimum of 6.4 and at low ionic strength.	Bilirubin	56-65	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	100-107
8375511-0	1993	Bilirubin attenuates radical-mediated damage to serum albumin.	Bilirubin	0-9	albumin	Homo sapiens	48-61
8225219-9	1993	Interleukin-1 receptor antagonist and tumor necrosis factor soluble receptor levels were also positively correlated with bilirubin and AST levels.	Bilirubin	121-130	tumor necrosis factor	Homo sapiens	38-59
8375511-3	1993	Here we show that bilirubin (BR), the end-product of heme catabolism, when bound to bovine serum albumin (BSA), is oxidised by hydroxyl (.OH), hydroperoxyl (HO2.), and superoxide anion (<compound-id="-">O2-.)	Bilirubin	18-27	albumin	Homo sapiens	91-104
8224617-4	1993	ET-1 levels showed negative correlations with serum albumin levels and Ch-Ease activities, and positive correlations with serum bilirubin levels, AST and ALT activities.	Bilirubin	128-137	endothelin 1	Homo sapiens	0-4
8274100-1	1993	The addition of human serum albumin (HSA) to peritoneal dialysate increases the clearance of bilirubin in rats suffering from obstructive jaundice.	Bilirubin	93-102	albumin	Rattus norvegicus	22-35
8355040-9	1993	Regression models were used to generate coefficients (beta 0, beta 1, beta 2) for the equation P = 1/(1 + e-z), where P is the probability of severe VOD and z = beta 0 + beta 1 (In total serum bilirubin [mg/dL]) + beta 2 (percent weight gain).	Bilirubin	193-202	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	54-76
8263676-3	1993	It seems the ACCB may be a good adsorbent system for the removal of toxic uric acid, creatinine, bilirubin, etc., from solutions; while larger molecules such as albumin are adsorbed less.	Bilirubin	97-106	acetyl-CoA carboxylase beta	Homo sapiens	13-17
8250204-29	1993	With increasing bilirubin levels, a lower O2Hb is measured with the CO 2500 than with the OSM3.	Bilirubin	16-25	kinesin family member 17	Homo sapiens	90-94
8250204-33	1993	With increasing bilirubin levels the MetHb concentration measured with the CO 2500 rises, while the OSM3 gives constant MetHb values.	Bilirubin	16-25	hemoglobin subunit gamma 2	Homo sapiens	37-42
8392204-0	1993	Na+,K(+)-ATPase and acetylcholinesterase activities: changes in postnatally developing rat brain induced by bilirubin.	Bilirubin	108-117	acetylcholinesterase	Rattus norvegicus	20-40
8220237-1	1993	Based on demonstrations that protoporphyrin-IX and its metabolic derivatives bilirubin and hemin bind to the red cell membrane, their association with glycophorin A, the main transmembrane sialoglycoprotein, was assessed.	Bilirubin	77-86	glycophorin A (MNS blood group)	Homo sapiens	151-164
8405382-2	1993	Human bilirubin UGT (HP3) and phenol UGT (HP4) both catalysed the glucuronidation of T4 and rT3, whereas glucuronidation of T3 was not significant, rT3 was the preferred substrate for both isoenzymes, glucuronidation rates being 1.6- and 6.4-times higher than conjugation of T4 by HP3 and HP4 clones, respectively.	Bilirubin	6-15	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	16-19
8405382-2	1993	Human bilirubin UGT (HP3) and phenol UGT (HP4) both catalysed the glucuronidation of T4 and rT3, whereas glucuronidation of T3 was not significant, rT3 was the preferred substrate for both isoenzymes, glucuronidation rates being 1.6- and 6.4-times higher than conjugation of T4 by HP3 and HP4 clones, respectively.	Bilirubin	6-15	defensin alpha 3	Homo sapiens	21-24
8517867-6	1993	Uridine diphospho-glucuronosyltransferase (UGT) 1A2 (bilirubin) activity and its induction by dexamethasone were not affected by IL-1 treatment.	Bilirubin	53-62	UDP glucuronosyltransferase 1 family, polypeptide A2	Rattus norvegicus	0-51
8225695-4	1993	In the treated group, there was a statistically significant reduction of mean (+/- SEM) serum concentrations of aspartate aminotransferase (AST) from 88.0 (+/- 13.3) to 65.9 (+/- 7.5) u/l, (p &lt; 0.01), of alanine aminotransferase (ALT) from 115.9 (+/- 12.9) to 82.5 (+/- 10.6) u/l (p &lt; 0.01), of gamma-glutamyltranspeptidase (gamma-GT) from 51.4 (+/- 9.3) to 41.3 (+/- 4.2) u/l (p &lt; 0.02) and of total bilirubin (TB) from 0.76 (+/- 0.08) to 0.53 (+/- 0.04) mg/dl (p &lt; 0.05).	Bilirubin	410-419	solute carrier family 17 member 5	Homo sapiens	112-138
8225695-4	1993	In the treated group, there was a statistically significant reduction of mean (+/- SEM) serum concentrations of aspartate aminotransferase (AST) from 88.0 (+/- 13.3) to 65.9 (+/- 7.5) u/l, (p &lt; 0.01), of alanine aminotransferase (ALT) from 115.9 (+/- 12.9) to 82.5 (+/- 10.6) u/l (p &lt; 0.01), of gamma-glutamyltranspeptidase (gamma-GT) from 51.4 (+/- 9.3) to 41.3 (+/- 4.2) u/l (p &lt; 0.02) and of total bilirubin (TB) from 0.76 (+/- 0.08) to 0.53 (+/- 0.04) mg/dl (p &lt; 0.05).	Bilirubin	410-419	solute carrier family 17 member 5	Homo sapiens	140-143
8225695-4	1993	In the treated group, there was a statistically significant reduction of mean (+/- SEM) serum concentrations of aspartate aminotransferase (AST) from 88.0 (+/- 13.3) to 65.9 (+/- 7.5) u/l, (p &lt; 0.01), of alanine aminotransferase (ALT) from 115.9 (+/- 12.9) to 82.5 (+/- 10.6) u/l (p &lt; 0.01), of gamma-glutamyltranspeptidase (gamma-GT) from 51.4 (+/- 9.3) to 41.3 (+/- 4.2) u/l (p &lt; 0.02) and of total bilirubin (TB) from 0.76 (+/- 0.08) to 0.53 (+/- 0.04) mg/dl (p &lt; 0.05).	Bilirubin	421-423	solute carrier family 17 member 5	Homo sapiens	112-138
8225695-4	1993	In the treated group, there was a statistically significant reduction of mean (+/- SEM) serum concentrations of aspartate aminotransferase (AST) from 88.0 (+/- 13.3) to 65.9 (+/- 7.5) u/l, (p &lt; 0.01), of alanine aminotransferase (ALT) from 115.9 (+/- 12.9) to 82.5 (+/- 10.6) u/l (p &lt; 0.01), of gamma-glutamyltranspeptidase (gamma-GT) from 51.4 (+/- 9.3) to 41.3 (+/- 4.2) u/l (p &lt; 0.02) and of total bilirubin (TB) from 0.76 (+/- 0.08) to 0.53 (+/- 0.04) mg/dl (p &lt; 0.05).	Bilirubin	421-423	solute carrier family 17 member 5	Homo sapiens	140-143
8514037-1	1993	BACKGROUND: Inherited unconjugated hyperbilirubinemia in Crigler-Najjar type II (CN II) is caused by a strong reduction of bilirubin uridine 5"-diphosphate-glucuronosyltransferase (B-UGT) activity.	Bilirubin	40-49	5'-nucleotidase, cytosolic II	Homo sapiens	57-79
8514037-1	1993	BACKGROUND: Inherited unconjugated hyperbilirubinemia in Crigler-Najjar type II (CN II) is caused by a strong reduction of bilirubin uridine 5"-diphosphate-glucuronosyltransferase (B-UGT) activity.	Bilirubin	40-49	5'-nucleotidase, cytosolic II	Homo sapiens	81-86
8514037-8	1993	This indicates that B-UGT1 is the physiological important bilirubin glucuronidating isoform.	Bilirubin	58-67	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	22-26
8405382-2	1993	Human bilirubin UGT (HP3) and phenol UGT (HP4) both catalysed the glucuronidation of T4 and rT3, whereas glucuronidation of T3 was not significant, rT3 was the preferred substrate for both isoenzymes, glucuronidation rates being 1.6- and 6.4-times higher than conjugation of T4 by HP3 and HP4 clones, respectively.	Bilirubin	6-15	defensin alpha 3	Homo sapiens	281-284
8405382-2	1993	Human bilirubin UGT (HP3) and phenol UGT (HP4) both catalysed the glucuronidation of T4 and rT3, whereas glucuronidation of T3 was not significant, rT3 was the preferred substrate for both isoenzymes, glucuronidation rates being 1.6- and 6.4-times higher than conjugation of T4 by HP3 and HP4 clones, respectively.	Bilirubin	6-15	defensin alpha 4	Homo sapiens	289-292
8405382-3	1993	This is the first identification of thyroid hormone as potential alternative endogenous substrate for bilirubin UGT.	Bilirubin	102-111	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	112-115
8513793-0	1993	The structural characterization and bilirubin-binding properties of albumin Herborn, a [Lys240-->Glu] albumin mutant.	Bilirubin	36-45	albumin	Homo sapiens	68-75
8513793-0	1993	The structural characterization and bilirubin-binding properties of albumin Herborn, a [Lys240-->Glu] albumin mutant.	Bilirubin	36-45	albumin	Homo sapiens	102-109
8513793-9	1993	The binding of bilirubin and biliverdin by albumin Herborn was quantified using the fluorescence quenching method.	Bilirubin	15-24	albumin	Homo sapiens	43-50
7909617-8	1993	HLA-DR8-positive primary biliary cirrhosis patients had a higher serum bilirubin level (p = 0.03) than DR8-negative patients.	Bilirubin	71-80	major histocompatibility complex, class II, DR beta 1	Homo sapiens	0-3
8392204-7	1993	The bilirubin immediate toxic effects on brain acetylcholinesterase and Na+,K(+)-ATPase, and probably on brain electrical activity, may be modulated by the developmental state of membrane-bound enzymes.	Bilirubin	4-13	acetylcholinesterase	Rattus norvegicus	47-67
8502229-10	1993	On the other hand, normal developmental activation of CYP1A2 may provide the alternative pathway for bilirubin degradation in adult animals.	Bilirubin	101-110	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	54-60
8502229-9	1993	These data suggest that young jaundiced Gunn rats cope with the degradation of toxic bilirubin by increasing hepatic levels of CYP1A1 and CYP1A2.	Bilirubin	85-94	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	127-133
8502229-9	1993	These data suggest that young jaundiced Gunn rats cope with the degradation of toxic bilirubin by increasing hepatic levels of CYP1A1 and CYP1A2.	Bilirubin	85-94	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	138-144
8330847-1	1993	Associations of blood PCB concentration with serum levels of triglyceride, gamma-GTP, total-, and conjugated-bilirubin were investigated in "Yusho" patients twenty years after outbreak, using the information obtained from the medical examinations in 1988 and 1989.	Bilirubin	109-118	pyruvate carboxylase	Homo sapiens	22-25
8321923-1	1993	The binding of hydroxy and keto bile salts to bovine serum albumin was studied using probes for the so-called site I, II, bilirubin and fatty acids.	Bilirubin	122-131	albumin	Homo sapiens	53-66
8483897-1	1993	Acyl glucuronide metabolites of bilirubin and many drugs can react with serum albumin in vivo to form covalent adducts.	Bilirubin	32-41	albumin	Homo sapiens	78-85
8474433-3	1993	Two cloned expressed human enzymes, a bilirubin UGT and a phenol UGT, were observed to catalyze the glucuronidation of ethinylestradiol.	Bilirubin	38-47	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	48-51
8513567-6	1993	In the jaundiced cases, the increased PLP and HLP levels were clearly related to the serum levels of bilirubin respectively.	Bilirubin	101-110	proteolipid protein 1	Homo sapiens	38-41
8470890-4	1993	On the other hand, there existed another hydrophobic ligand-binding region in GST-P, to which 1-amino-8-naphthalenesulfonic acid and bilirubin would bind with relatively lower affinity than the endogenously bound fatty acid.	Bilirubin	133-142	glutathione S-transferase pi 1	Homo sapiens	78-83
8474433-3	1993	Two cloned expressed human enzymes, a bilirubin UGT and a phenol UGT, were observed to catalyze the glucuronidation of ethinylestradiol.	Bilirubin	38-47	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	65-68
8474433-4	1993	High performance liquid chromatographic analysis of the products formed revealed that the expressed bilirubin UGT specifically produced ethinylestradiol-3-glucuronide.	Bilirubin	100-109	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	110-113
8474433-6	1993	Subsequent study of the cloned expressed enzymes and human liver microsomes from Crigler-Najjar patients by kinetic analysis and by substrate inhibition strongly indicated that a human liver bilirubin UGT was largely responsible for glucuronidation of ethinylestradiol.	Bilirubin	191-200	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	201-204
8464825-0	1993	Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p).	Bilirubin	50-59	UDP glucuronosyltransferase 1 family, polypeptide A9	Mus musculus	107-115
18965666-4	1993	The study was extended to examine the interactions of bilirubin and two anionic drugs, warfarin and naproxen, with HSA and the three fragments.	Bilirubin	54-63	albumin	Homo sapiens	115-118
18965666-5	1993	The primary bilirubin binding site on HSA molecule appeared to be located between fragment A and fragment C. The results also suggest the binding sites of the two anionic drugs to mosy likely be located in fragment C of HSA molecule.	Bilirubin	12-21	albumin	Homo sapiens	38-41
18965666-5	1993	The primary bilirubin binding site on HSA molecule appeared to be located between fragment A and fragment C. The results also suggest the binding sites of the two anionic drugs to mosy likely be located in fragment C of HSA molecule.	Bilirubin	12-21	albumin	Homo sapiens	220-223
8435089-3	1993	Bilirubin UGTs (HP2 and HP3) were not detectable in the kidney and HP3 was the major isoform in the liver.	Bilirubin	0-9	defensin alpha 3	Homo sapiens	24-27
8223024-3	1993	The ratio of CD4/CD8 was low at the first 10 days of jaundice when the serum bilirubin level was less than 171 mumol/L.	Bilirubin	77-86	CD4 molecule	Homo sapiens	13-16
8223024-3	1993	The ratio of CD4/CD8 was low at the first 10 days of jaundice when the serum bilirubin level was less than 171 mumol/L.	Bilirubin	77-86	CD8a molecule	Homo sapiens	17-20
8096554-1	1993	The hyperbilirubinemic Gunn rat lacks hepatic UDP-glucuronosyltransferase (UDPGT) activity toward bilirubin and has been used as an animal model for human Crigler-Najjar syndrome type I. Rat liver bilirubin UDPGT cDNA was isolated.	Bilirubin	9-18	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	46-73
8096554-1	1993	The hyperbilirubinemic Gunn rat lacks hepatic UDP-glucuronosyltransferase (UDPGT) activity toward bilirubin and has been used as an animal model for human Crigler-Najjar syndrome type I. Rat liver bilirubin UDPGT cDNA was isolated.	Bilirubin	9-18	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	75-80
8096554-1	1993	The hyperbilirubinemic Gunn rat lacks hepatic UDP-glucuronosyltransferase (UDPGT) activity toward bilirubin and has been used as an animal model for human Crigler-Najjar syndrome type I. Rat liver bilirubin UDPGT cDNA was isolated.	Bilirubin	9-18	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	207-212
8096554-1	1993	The hyperbilirubinemic Gunn rat lacks hepatic UDP-glucuronosyltransferase (UDPGT) activity toward bilirubin and has been used as an animal model for human Crigler-Najjar syndrome type I. Rat liver bilirubin UDPGT cDNA was isolated.	Bilirubin	98-107	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	46-73
8096554-1	1993	The hyperbilirubinemic Gunn rat lacks hepatic UDP-glucuronosyltransferase (UDPGT) activity toward bilirubin and has been used as an animal model for human Crigler-Najjar syndrome type I. Rat liver bilirubin UDPGT cDNA was isolated.	Bilirubin	98-107	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	75-80
8096554-3	1993	The bilirubin UDPGT gene was mapped at the position of 37 on mouse chromosome 1 by analyzing restriction endonuclease fragment length variations using the rat bilirubin UDPGT cDNA as a probe.	Bilirubin	4-13	UDP glucuronosyltransferase 1 family, polypeptide A6A	Mus musculus	14-19
8096554-3	1993	The bilirubin UDPGT gene was mapped at the position of 37 on mouse chromosome 1 by analyzing restriction endonuclease fragment length variations using the rat bilirubin UDPGT cDNA as a probe.	Bilirubin	4-13	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	169-174
8096554-3	1993	The bilirubin UDPGT gene was mapped at the position of 37 on mouse chromosome 1 by analyzing restriction endonuclease fragment length variations using the rat bilirubin UDPGT cDNA as a probe.	Bilirubin	159-168	UDP glucuronosyltransferase 1 family, polypeptide A6A	Mus musculus	14-19
8096554-4	1993	The genetic defect of bilirubin UDPGT in the mutant rat was proved to be a -1 frameshift mutation.	Bilirubin	22-31	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	32-37
8096554-5	1993	The mutation was found not only to be located in the region where the cDNA for bilirubin UDPGT shared the identical sequence with that for phenol UDPGT but also to occur in the same position in the two cDNAs from the mutant.	Bilirubin	79-88	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	89-94
8096554-5	1993	The mutation was found not only to be located in the region where the cDNA for bilirubin UDPGT shared the identical sequence with that for phenol UDPGT but also to occur in the same position in the two cDNAs from the mutant.	Bilirubin	79-88	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	146-151
8284577-7	1993	3) In both the ABO and Rh groups, the indirect bilirubin value that most closely approached the level for EXT indication was that obtained 3 hours post-EXT (least significant percent difference).	Bilirubin	47-56	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	15-18
8435089-5	1993	Bilirubin UGT HP3 was induced 2-3-fold in the livers from patients treated with phenytoin and phenobarbital.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	10-13
8435089-5	1993	Bilirubin UGT HP3 was induced 2-3-fold in the livers from patients treated with phenytoin and phenobarbital.	Bilirubin	0-9	defensin alpha 3	Homo sapiens	14-17
7678928-4	1993	A logistic regression analysis indicated that high alpha-fetoprotein concentrations in cord blood, history of neonatal jaundice in previous full-term siblings, delayed first meconium passage and weight loss were associated with jaundice, defined as a serum bilirubin level &gt; 11.9 mg/dl.	Bilirubin	257-266	alpha fetoprotein	Homo sapiens	51-68
7677965-8	1993	As compared with hydroxyurea alone, treatment with hydroxyurea and erythropoietin decreased the mean (+/- SD) serum indirect bilirubin level from 0.8 +/- 0.2 to 0.5 +/- 0.1 mg per deciliter (13.3 +/- 2.9 to 8.9 +/- 2.2 mumol per liter) (P = 0.02), suggesting a further decrease in hemolysis.	Bilirubin	125-134	erythropoietin	Homo sapiens	67-81
8444404-4	1993	The binding region was determined to be at around 142-157 residues from amino terminus by the studies of GST-P binding to fatty acid-linked Sepharose and affinity labelings with either fluorescent fatty acid or bilirubin.	Bilirubin	211-220	glutathione S-transferase pi 1	Homo sapiens	105-110
8518741-4	1993	The induction process is concomitant with that of cytochrome P-450-IVA1 and cytosolic epoxide hydrolase, which, like bilirubin UGT, are mainly involved in the metabolism of endogenous substrates.	Bilirubin	117-126	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	50-71
8518741-4	1993	The induction process is concomitant with that of cytochrome P-450-IVA1 and cytosolic epoxide hydrolase, which, like bilirubin UGT, are mainly involved in the metabolism of endogenous substrates.	Bilirubin	117-126	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	127-130
8518741-6	1993	Until now, the molecular basis of induction of bilirubin UGT is not known.	Bilirubin	47-56	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	57-60
8518741-9	1993	There is convincing evidence that UGT bilirubin does not catalyze the glucuronidation of these substances even if the two types of substrate form acylglucuronides.	Bilirubin	38-47	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	34-37
8467709-2	1993	The sub-family of UGTs that conjugate bilirubin and phenolic compounds with glucuronic acid has been termed UGT1A1.	Bilirubin	38-47	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	108-114
8467709-5	1993	In the present study, we used the cDNA of UGT1A1*4, a bilirubin-conjugating isoform, to localize the UGT1A1 locus in the human genome.	Bilirubin	54-63	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	42-48
8467709-5	1993	In the present study, we used the cDNA of UGT1A1*4, a bilirubin-conjugating isoform, to localize the UGT1A1 locus in the human genome.	Bilirubin	54-63	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	101-107
8423544-5	1993	The increase in HO-1 mRNA was reflected in HO-1 protein level, as judged by Western blot analysis and at the level of activity as judged by the rate of bilirubin formation.	Bilirubin	152-161	heme oxygenase 1	Rattus norvegicus	16-20
1455431-8	1992	Total SBA levels as assayed by the kit were elevated in response to CCl4 and CHCl3 at doses below which serum enzymes and bilirubin were increased.	Bilirubin	122-131	C-C motif chemokine ligand 4	Rattus norvegicus	68-72
8446043-6	1993	LCAT activity was positively correlated with serum albumin (r = .52, P &lt; 0.1) and cholinesterase (r = .37, P &lt; .01) levels, and inversely correlated with serum bilirubin level (r = -.38, P &lt; 0.1); there was no correlation between plasma LTP activity and these parameters of liver function.	Bilirubin	166-175	lecithin-cholesterol acyltransferase	Homo sapiens	0-4
1466355-8	1992	High beta 2M levels were more common among patients with older age, with elevated creatinine, bilirubin, and alkaline phosphatase levels, with low albumin levels, and with B-cell disease.	Bilirubin	94-103	beta-2-microglobulin	Homo sapiens	5-12
1446596-5	1992	The increases in bilirubin, alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase were markedly attenuated when HGF was administered 30 min before ANIT and again at 6, 12, 24, 30, and 36 h after ANIT.	Bilirubin	17-26	hepatocyte growth factor	Homo sapiens	136-139
1359996-8	1992	Somatostatin infusion improved the animals" survival rates from 0% (group 3) to 60% (group 4) (p &lt; 0.05) and decreased bilirubin levels (0.78 +/- 0.17 mg/dl, n = 15 [group 4] vs. 1.69 +/- 0.04 mg/dl, n = 15 [group 3]; p &lt; 0.05).	Bilirubin	122-131	somatostatin	Rattus norvegicus	0-12
1427661-5	1992	Hepatocyte growth factor prevented any marked increase in the serum levels of liver enzymes and bilirubin when it was administered to mice also treated with alpha-naphthylisothiocyanate (control: ALT, 394 +/- 278 IU/L; lactate dehydrogenase, 2,644 +/- 1,109 IU/L; bilirubin, 9.6 +/- 2.6 mg/dl; and 5 micrograms hepatocyte growth factor: ALT, 135 +/- 7.9 IU/L; lactate dehydrogenase, 1,672 +/- 626 IU/L; bilirubin, 1.0 +/- 0.8 mg/dl).	Bilirubin	96-105	hepatocyte growth factor	Mus musculus	0-24
1426383-11	1992	The higher levels of conjugated bilirubin noted in the FF could in part be explained by the lower levels of beta-glucuronidase.	Bilirubin	32-41	glucuronidase beta	Homo sapiens	108-126
1421368-4	1992	Five patients responded to therapy with prompt reduction in total serum bilirubin within 96 hours of starting tPA.	Bilirubin	72-81	chromosome 20 open reading frame 181	Homo sapiens	110-113
1426882-3	1992	Multiple regression analysis showed that such maximal hepatocyte growth factor levels were significantly related to having liver cirrhosis and postoperative maximal serum total bilirubin and alanine aminotransferase levels and peripheral white blood cell counts in the hepatectomized group and to postoperative maximal peripheral white blood cell counts and serum C-reactive protein levels in the nonhepatectomized group.	Bilirubin	177-186	hepatocyte growth factor	Homo sapiens	54-78
1427661-5	1992	Hepatocyte growth factor prevented any marked increase in the serum levels of liver enzymes and bilirubin when it was administered to mice also treated with alpha-naphthylisothiocyanate (control: ALT, 394 +/- 278 IU/L; lactate dehydrogenase, 2,644 +/- 1,109 IU/L; bilirubin, 9.6 +/- 2.6 mg/dl; and 5 micrograms hepatocyte growth factor: ALT, 135 +/- 7.9 IU/L; lactate dehydrogenase, 1,672 +/- 626 IU/L; bilirubin, 1.0 +/- 0.8 mg/dl).	Bilirubin	264-273	hepatocyte growth factor	Mus musculus	0-24
1427661-5	1992	Hepatocyte growth factor prevented any marked increase in the serum levels of liver enzymes and bilirubin when it was administered to mice also treated with alpha-naphthylisothiocyanate (control: ALT, 394 +/- 278 IU/L; lactate dehydrogenase, 2,644 +/- 1,109 IU/L; bilirubin, 9.6 +/- 2.6 mg/dl; and 5 micrograms hepatocyte growth factor: ALT, 135 +/- 7.9 IU/L; lactate dehydrogenase, 1,672 +/- 626 IU/L; bilirubin, 1.0 +/- 0.8 mg/dl).	Bilirubin	264-273	hepatocyte growth factor	Mus musculus	0-24
1398505-4	1992	Changes in metabolic clearance rate and half-time of arginine vasopressin correlated with the score of the liver dysfunction, prothrombin activity and levels of serum albumin and bilirubin but not with parameters of kidney function (serum creatinine levels and clearance of creatinine).	Bilirubin	179-188	arginine vasopressin	Homo sapiens	62-73
1394036-9	1992	There was a significant positive correlation between TFPI levels and bilirubin levels; the correlation coefficient at diagnosis was 0.70 (P &lt; 0.001).	Bilirubin	69-78	tissue factor pathway inhibitor	Homo sapiens	53-57
1419619-6	1992	Epirubicin clearance was significantly reduced in the patients with a raised AST, whether their serum bilirubin was normal (22 patients) or elevated (eight patients).	Bilirubin	102-111	solute carrier family 17 member 5	Homo sapiens	77-80
1385560-6	1992	CBP was isolated from proteins precipitated from bile by CaCl2, as well as from the calcium bilirubinate shells of cholesterol gallstones, by extraction successively with methyl-t-butyl ether, methanol, and Na2EDTA, followed by Sephadex G-25 chromatography and two-stage preparative SDS-PAGE.	Bilirubin	84-104	CREB binding protein	Homo sapiens	0-3
1634606-0	1992	Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar type I patient.	Bilirubin	55-64	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	100-104
1512236-2	1992	Hepatic biotransformation of bilirubin to the hydrophilic species bilirubin mono- (BMG) and diglucuronide (BDG) by microsomal bilirubin UDP-glucuronosyl-transferase (GT) is a prerequisite for its physiologic excretion into bile.	Bilirubin	29-38	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	136-164
1512236-2	1992	Hepatic biotransformation of bilirubin to the hydrophilic species bilirubin mono- (BMG) and diglucuronide (BDG) by microsomal bilirubin UDP-glucuronosyl-transferase (GT) is a prerequisite for its physiologic excretion into bile.	Bilirubin	29-38	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	166-168
1512236-2	1992	Hepatic biotransformation of bilirubin to the hydrophilic species bilirubin mono- (BMG) and diglucuronide (BDG) by microsomal bilirubin UDP-glucuronosyl-transferase (GT) is a prerequisite for its physiologic excretion into bile.	Bilirubin	66-75	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	136-164
1512236-2	1992	Hepatic biotransformation of bilirubin to the hydrophilic species bilirubin mono- (BMG) and diglucuronide (BDG) by microsomal bilirubin UDP-glucuronosyl-transferase (GT) is a prerequisite for its physiologic excretion into bile.	Bilirubin	66-75	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	166-168
1512236-3	1992	The reaction mechanism of bilirubin-GT and the access of bilirubin and BMG (the intermediate substrate) to the active site of bilirubin-GT are undefined.	Bilirubin	26-35	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	36-38
1512236-8	1992	These findings indicate that: 1) bilirubin-GT follows Michaelis-Menten kinetics for both bilirubin and BMG glucuronidation over the range of substrate concentrations employed; 2) the findings are consistent with a single active site for the enzymatic synthesis of both BMG and BDG; 3) bilirubin, BMG, and BDG bind competitively to this active site with comparable affinities; and 4) access of both bilirubin and BMG substrates to the enzymatic active site is reduced by soluble binding proteins.	Bilirubin	33-42	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	43-45
1512236-8	1992	These findings indicate that: 1) bilirubin-GT follows Michaelis-Menten kinetics for both bilirubin and BMG glucuronidation over the range of substrate concentrations employed; 2) the findings are consistent with a single active site for the enzymatic synthesis of both BMG and BDG; 3) bilirubin, BMG, and BDG bind competitively to this active site with comparable affinities; and 4) access of both bilirubin and BMG substrates to the enzymatic active site is reduced by soluble binding proteins.	Bilirubin	89-98	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	43-45
1512236-8	1992	These findings indicate that: 1) bilirubin-GT follows Michaelis-Menten kinetics for both bilirubin and BMG glucuronidation over the range of substrate concentrations employed; 2) the findings are consistent with a single active site for the enzymatic synthesis of both BMG and BDG; 3) bilirubin, BMG, and BDG bind competitively to this active site with comparable affinities; and 4) access of both bilirubin and BMG substrates to the enzymatic active site is reduced by soluble binding proteins.	Bilirubin	89-98	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	43-45
1512236-8	1992	These findings indicate that: 1) bilirubin-GT follows Michaelis-Menten kinetics for both bilirubin and BMG glucuronidation over the range of substrate concentrations employed; 2) the findings are consistent with a single active site for the enzymatic synthesis of both BMG and BDG; 3) bilirubin, BMG, and BDG bind competitively to this active site with comparable affinities; and 4) access of both bilirubin and BMG substrates to the enzymatic active site is reduced by soluble binding proteins.	Bilirubin	89-98	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	43-45
1359870-1	1992	Restriction endonuclease fragment length variations (RFLVs) were detected by using a rat cDNA probe for the bilirubin UDP-glucuronosyltransferase (UDPGT) gene between two mouse strains, 129/Sv and MOL-MIT.	Bilirubin	108-117	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	118-145
1359870-1	1992	Restriction endonuclease fragment length variations (RFLVs) were detected by using a rat cDNA probe for the bilirubin UDP-glucuronosyltransferase (UDPGT) gene between two mouse strains, 129/Sv and MOL-MIT.	Bilirubin	108-117	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	147-152
1359870-3	1992	From linkage analyses of the three-point cross test using Elo and En-1 as marker genes, the bilirubin UDPGT gene was mapped at position 37 on chromosome 1.	Bilirubin	92-101	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	102-107
1359870-5	1992	The mouse bilirubin UDPGT gene was named Gnt-1.	Bilirubin	10-19	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	20-25
1359870-5	1992	The mouse bilirubin UDPGT gene was named Gnt-1.	Bilirubin	10-19	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	41-46
1381998-6	1992	When bilirubin-treated cells were stained with fluorescein-labeled anti-CD14 antibody, the CD14 positive cell population can be fractionated without interference of autofluorescence derived from intracellular bilirubin.	Bilirubin	5-14	CD14 molecule	Homo sapiens	72-76
1381998-6	1992	When bilirubin-treated cells were stained with fluorescein-labeled anti-CD14 antibody, the CD14 positive cell population can be fractionated without interference of autofluorescence derived from intracellular bilirubin.	Bilirubin	5-14	CD14 molecule	Homo sapiens	91-95
1381998-6	1992	When bilirubin-treated cells were stained with fluorescein-labeled anti-CD14 antibody, the CD14 positive cell population can be fractionated without interference of autofluorescence derived from intracellular bilirubin.	Bilirubin	209-218	CD14 molecule	Homo sapiens	72-76
1634050-0	1992	Mechanisms of inherited deficiencies of multiple UDP-glucuronosyltransferase isoforms in two patients with Crigler-Najjar syndrome, type I. Crigler-Najjar syndrome, type I (CN-I) is a potentially lethal disorder characterized by severe unconjugated hyperbilirubinemia resulting from a recessively inherited deficiency of hepatic UDP-glucuronosyl-transferase (UGT) activity toward bilirubin (B-UGT).	Bilirubin	254-263	5'-nucleotidase, cytosolic IA	Homo sapiens	173-177
1499725-4	1992	The expressed enzyme specifically catalysed the formation of bilirubin mono- and diglucuronides, and also catalysed the glucuronidation of two phenolic compounds, which are good substrates for other human UGT isoenzymes, at low rates.	Bilirubin	61-70	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	205-208
1634606-6	1992	266:1043-1047) led to the discovery of a unique locus, UGT1, which encodes a family of UDP-glucuronosyltransferase isozymes, including the two bilirubin forms (Ritter, J. K., F. Chen, Y. Y. Sheen, H. M. Tran, S. Kimura, M. T. Yeatman, and I. S. Owens.	Bilirubin	143-152	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	55-59
1610897-9	1992	Together, these findings and the fact that HO-2 under normal conditions is the predominant form of the enzyme in most organs suggest that loss of HO-2 protein integrity may to a significant degree account for suppression of bilirubin formation by Sn-protoporphyrin.	Bilirubin	224-233	heme oxygenase 2	Rattus norvegicus	146-150
1547853-0	1992	Effect of volatile anesthetics on the circular dichroism of bilirubin bound to human serum albumin.	Bilirubin	60-69	albumin	Homo sapiens	85-98
1626786-4	1992	Compared with the control and haptoglobin-negative cattle, haptoglobin-positive cattle had significantly (P less than 0.01) higher liver triglyceride content, serum bilirubin concentration, and aspartate transaminase activity.	Bilirubin	165-174	haptoglobin	Bos taurus	59-70
1599427-6	1992	Bilirubin and testosterone UDPGT activities were more labile and, although purified over 200-fold, these preparations also contained the phenol UDPGT and had multiple polypeptides with molecular masses of 52-57 kDa.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A5	Rattus norvegicus	144-149
1599427-7	1992	Antisera to rat bilirubin/phenol UDPGT and testosterone/phenol UDPGT isoforms cross-reacted strongly with the partially purified plaice UDPGT isoforms of molecular masses 52, 53 and 57 kDa and less strongly with phenol UDPGT 54 kDa and 56 kDa isoforms.	Bilirubin	16-25	UDP glucuronosyltransferase family 1 member A5	Rattus norvegicus	33-38
1566846-5	1992	ATP-dependent BSP transport was inhibited by oxidized glutathione, dinitrophenyl-glutathione (GSDNP), BSP glutathione, and bilirubin diglucuronide but not by daunomycin, taurocholate, and reduced glutathione.	Bilirubin	123-132	integrin-binding sialoprotein	Rattus norvegicus	14-17
1547853-1	1992	The characteristic circular dichroism of bilirubin bound to human serum albumin undergoes a remarkable sign inversion on addition of halothane, chloroform and other volatile anesthetics.	Bilirubin	41-50	albumin	Homo sapiens	66-79
1571497-4	1992	Among the three parameters obtained by model analysis, k12 values more prominently differed among diseases and correlated well with blood tests such as total bilirubin, total bile acids, or 15 min retention of ICG.	Bilirubin	158-167	keratin 12	Homo sapiens	55-58
1497481-10	1992	The activities of AST (aspartate aminotransferase) and ALT (alanine aminotransferase) were significantly increased after TBTO treatment, but those of ALP (alkaline phosphatase), LAP (leucine aminopeptidase) and total bilirubin were not changed.	Bilirubin	217-226	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	18-21
1610952-2	1992	Previous work has shown levels of the enzyme beta-glucuronidase in maternal breast milk to be related to infant serum bilirubin on postnatal day 21.	Bilirubin	118-127	glucuronidase beta	Homo sapiens	45-63
1530786-2	1992	Serum human hepatocyte growth factor levels were increased in correlation with derangements of prothrombin time, total bilirubin and other parameters reflecting hepatocellular dysfunction in 112 patients with chronic liver disease.	Bilirubin	119-128	hepatocyte growth factor	Homo sapiens	12-36
1634327-0	1992	Ionization of tyrosine residues in human serum albumin and in its complexes with bilirubin and laurate.	Bilirubin	81-90	albumin	Homo sapiens	41-54
1296961-5	1992	Also in breast-fed infants serum bilirubin concentrations were related to beta-glucuronidase activity in breast milk (p &lt; 0.05): Breast milk beta-glucuronidase--by facilitating intestinal reabsorption of bilirubin--seems to be an important factor in the neonatal hyperbilirubinemia of breast-fed babies.	Bilirubin	33-42	glucuronidase beta	Homo sapiens	74-92
1296961-5	1992	Also in breast-fed infants serum bilirubin concentrations were related to beta-glucuronidase activity in breast milk (p &lt; 0.05): Breast milk beta-glucuronidase--by facilitating intestinal reabsorption of bilirubin--seems to be an important factor in the neonatal hyperbilirubinemia of breast-fed babies.	Bilirubin	33-42	glucuronidase beta	Homo sapiens	144-162
1296961-5	1992	Also in breast-fed infants serum bilirubin concentrations were related to beta-glucuronidase activity in breast milk (p &lt; 0.05): Breast milk beta-glucuronidase--by facilitating intestinal reabsorption of bilirubin--seems to be an important factor in the neonatal hyperbilirubinemia of breast-fed babies.	Bilirubin	207-216	glucuronidase beta	Homo sapiens	74-92
1296961-5	1992	Also in breast-fed infants serum bilirubin concentrations were related to beta-glucuronidase activity in breast milk (p &lt; 0.05): Breast milk beta-glucuronidase--by facilitating intestinal reabsorption of bilirubin--seems to be an important factor in the neonatal hyperbilirubinemia of breast-fed babies.	Bilirubin	207-216	glucuronidase beta	Homo sapiens	144-162
1752967-3	1991	Furthermore, the chloride-activated portion of BSP uptake was inhibited by bilirubin (10 microM; inhibition 53%), 4,4"-diisothiocyano-2,2-disulfonic acid stilbene (DIDS, 100 microM; 80%), taurocholate (100 microM; 80%), and cholate (200 microM; 95%).	Bilirubin	75-84	integrin-binding sialoprotein	Rattus norvegicus	47-50
1815533-19	1991	The pathological serum bilirubin level of CCl4 lesion was normalised by tamoxifen as well as levonorgestrel treatment.	Bilirubin	23-32	C-C motif chemokine ligand 4	Rattus norvegicus	42-46
1740642-3	1992	In vitro incubation of PBMNCs at 37 degrees C with 0-12 mg/dl bilirubin in solution with a fixed bovine serum albumin (BSA) concentration (3.0 g/dl) resulted in a dose-dependent increase of intracellular bilirubin in both monocytes and lymphocytes.	Bilirubin	62-71	albumin	Homo sapiens	104-117
1740642-3	1992	In vitro incubation of PBMNCs at 37 degrees C with 0-12 mg/dl bilirubin in solution with a fixed bovine serum albumin (BSA) concentration (3.0 g/dl) resulted in a dose-dependent increase of intracellular bilirubin in both monocytes and lymphocytes.	Bilirubin	204-213	albumin	Homo sapiens	104-117
1959864-5	1991	beta-Glucuronidase activity was only detected in one sample, suggesting that the calcium bilirubinate may have been formed through tissue glucuronidases.	Bilirubin	81-101	glucuronidase beta	Homo sapiens	0-18
1725995-7	1991	HSA-bound cefotiam was displaced by FFA (1260 microM) and bilirubin (330 microM), whereas the cyclohexanol binding was inhibited only by FFA.	Bilirubin	58-67	albumin	Homo sapiens	0-3
1951226-3	1991	Direct bilirubin tests were ordered 15 times as often per infant at the University of California, San Francisco, as at Stanford (Calif) University, and the reported results were more than twice as high.	Bilirubin	7-16	CCR4-NOT transcription complex subunit 8	Homo sapiens	86-91
1855300-0	1991	Effects of serum-isolated vs synthetic bilirubin-albumin complexes on dye-binding methods for estimating serum albumin.	Bilirubin	39-48	albumin	Homo sapiens	105-118
1890152-7	1991	GH-BP correlated negatively with Pugh"s score and serum bilirubin, and positively with serum albumin.	Bilirubin	56-65	growth hormone receptor	Homo sapiens	0-5
1779231-4	1991	Excess of bilirubin administration decreased the total phospholipid level and inhibited the phospholipase A2 activity.	Bilirubin	10-19	phospholipase A2 group IB	Rattus norvegicus	92-108
1779231-5	1991	Cr-PP (chromium protoporphyrin) induces the phospholipase A2 activity which is inhibited by simultaneous bilirubin administration.	Bilirubin	105-114	phospholipase A2 group IB	Rattus norvegicus	44-60
1799122-4	1991	The result indicates that daylight is one of the significant factors affecting TcB measurement at the forehead, contributing to poor correlation between TcB reading at the forehead and serum bilirubin concentrations.	Bilirubin	191-200	pyruvate kinase M1/2	Homo sapiens	79-82
1717446-2	1991	Gunn rats lack UDP-glucuronosyltransferase (UDPGT) activity toward bilirubin.	Bilirubin	67-76	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	15-42
1717446-2	1991	Gunn rats lack UDP-glucuronosyltransferase (UDPGT) activity toward bilirubin.	Bilirubin	67-76	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	44-49
1717446-4	1991	The hepatic concentration of bilirubin-UDPGT mRNA was lower in Gunn rats than in congeneic normal rats.	Bilirubin	29-38	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	39-44
1717446-5	1991	However, bilirubin-UDPGT mRNA was of apparently normal length and was induced by clofibrate, a known inducer of bilirubin-UDPGT activity.	Bilirubin	9-18	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	19-24
1717446-5	1991	However, bilirubin-UDPGT mRNA was of apparently normal length and was induced by clofibrate, a known inducer of bilirubin-UDPGT activity.	Bilirubin	9-18	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	122-127
1717446-5	1991	However, bilirubin-UDPGT mRNA was of apparently normal length and was induced by clofibrate, a known inducer of bilirubin-UDPGT activity.	Bilirubin	112-121	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	19-24
1717446-5	1991	However, bilirubin-UDPGT mRNA was of apparently normal length and was induced by clofibrate, a known inducer of bilirubin-UDPGT activity.	Bilirubin	112-121	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	122-127
1717446-6	1991	3" regions of bilirubin- and 3-MC-inducible UDPGT mRNAs have identical nucleotide sequences; the single base deletion in the 3-MC-inducible UDPGT in Gunn rats occurs within this region.	Bilirubin	14-23	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	44-49
1717446-6	1991	3" regions of bilirubin- and 3-MC-inducible UDPGT mRNAs have identical nucleotide sequences; the single base deletion in the 3-MC-inducible UDPGT in Gunn rats occurs within this region.	Bilirubin	14-23	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	140-145
1717446-9	1991	Nucleotide sequence determination revealed that bilirubin- and 3-MC-inducible UDPGT mRNAs in Gunn rats contain an identical frame-shift deletion of a single guanosine residue within the common region of their coding sequences.	Bilirubin	48-57	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	78-83
1874495-7	1991	Cox regression analysis selected only bilirubin and galactose elimination capacity, however, as independent predictors of death.	Bilirubin	38-47	cytochrome c oxidase subunit 8A	Homo sapiens	0-3
1826661-0	1991	The anionic conjugates of bilirubin and bile acids stimulate ATP hydrolysis by S-(dinitrophenyl)glutathione ATPase of human erythrocyte.	Bilirubin	26-35	dynein axonemal heavy chain 8	Homo sapiens	108-114
1786835-1	1991	Three and ten days after the administration of CCl4 (subcutaneously, once, 4 ml/kg of 50% oil solution) there were found a decrease of the rate of antipyrine elimination (intravenously, 50 mg/kg) from the blood plasma, an increase of the total bilirubin content, ALT activity and stimulation of lipid peroxidation processes.	Bilirubin	244-253	C-C motif chemokine 4	Oryctolagus cuniculus	47-51
1713709-7	1991	As expected, infusion of CCK-8 at both doses stimulated pancreatic exocrine secretion and gallbladder contraction in placebo controls, as indicated by increases in the output of trypsin, amylase, bicarbonate, and bilirubin.	Bilirubin	213-222	cholecystokinin	Homo sapiens	25-28
1840486-2	1991	The mutation was found not only to be located in the region where bilirubin UDPGT cDNA shared an identical sequence with 3-methylcholanthrene (3M C)-inducible UDPGT cDNA but also to occur in the same position on the two cDNAs from the mutant rat.	Bilirubin	66-75	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	76-81
1840486-2	1991	The mutation was found not only to be located in the region where bilirubin UDPGT cDNA shared an identical sequence with 3-methylcholanthrene (3M C)-inducible UDPGT cDNA but also to occur in the same position on the two cDNAs from the mutant rat.	Bilirubin	66-75	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	159-164
2044224-4	1991	IL-6 levels were higher in patients who died (P = 0.04) and correlated with the features of severe disease including: increased grade of encephalopathy, increased neutrophil count, increased prothrombin ratio, hypotension, increased serum creatinine and increased serum bilirubin.	Bilirubin	270-279	interleukin 6	Homo sapiens	0-4
1920916-1	1991	The human liver bilirubin UDP-glucuronosyl transferase (bilirubin UDPGT) [EC 2.4.1.17] is responsible for the enzyme deficiency in Crigler-Najjar syndrome and/or Gilbert"s syndrome.	Bilirubin	16-25	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	66-71
1920916-2	1991	The UDPGT, former shows severe jaundice resulted from a complete absence of bilirubin while the latter has a mild manifestation due to a reduction of the enzyme activity.	Bilirubin	76-85	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	4-9
1920916-3	1991	The gene locus of bilirubin UDPGT was mapped to chromosome 1 by spot-blot hybridization using a cell-sorter, and its regional locus was assigned to 1q21-q23 by high resolution in situ hybridization.	Bilirubin	18-27	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	28-33
1714084-4	1991	In the control experiments saline infusion failed to influence basal amylase, trypsin and bilirubin output, while bombesin stimulated amylase output from 4.7 +/- 0.8 kU/45 min to 25.1 +/- 5.1 kU/45 min (P less than 0.05), trypsin output from 2.9 +/- 0.8 kU/45 min to 11.6 +/- 2.0 kU/45 min (P less than 0.05) and bilirubin output from 7.7 +/- 2.8 mmol/45 min to 68.0 +/- 16.0 mmol/45 min (P less than 0.05).	Bilirubin	313-322	gastrin releasing peptide	Homo sapiens	114-122
2015277-4	1991	Using modified MBS (metamaleimidobenzoyl-N-hydroxysuccinimide ester) method, bilirubin-IX alpha was covalently coupled to bovine serum albumin (BSA) retaining its intramolecular hydrogen bonds as well as three-dimensional structure.	Bilirubin	77-86	albumin	Mus musculus	129-142
2058389-5	1991	Our findings suggest that the binding properties of serum albumin contribute to the risk of bilirubin toxicity and that, in this study, the reserve albumin concentration for MADDS seemed to be of greater significance than the total bilirubin concentration.	Bilirubin	92-101	albumin	Homo sapiens	52-65
1827256-0	1991	Purification and characterization of an ATPase from human liver which catalyzes ATP hydrolysis in the presence of the conjugates of bilirubin bile acids and glutathione.	Bilirubin	132-141	dynein axonemal heavy chain 8	Homo sapiens	40-46
1827256-3	1991	Kinetic constants of the enzyme for the conjugates of glutathione, bile acids and bilirubin are comparable indicating that this ATPase may mediate active transport of all these anionic conjugates in liver.	Bilirubin	82-91	dynein axonemal heavy chain 8	Homo sapiens	128-134
2003987-6	1991	Correlations were found between DU-PAN-2 and (1) total bilirubin, (2) alanine-amino-transferase and (3) alkaline phosphatase.	Bilirubin	55-64	poly(A) specific ribonuclease subunit PAN2	Homo sapiens	35-40
1991139-9	1991	In contrast, the transport of a typical substrate of the bilirubin carrier (rifampicin), of amino acids (alpha-aminoisobutyric acid), long chain fatty acids (oleic acid) and cationic compounds (thiamin hydrochloride) was not inhibited by the same renin inhibitors.	Bilirubin	57-66	renin	Homo sapiens	247-252
1996640-2	1991	Infusion of CCK-8, producing CCK plasma levels of 10-12 pmol/l, decreased gallbladder volume to 21% of the initial volume (P less than 0.01) and increased bilirubin output 8- to 10-fold and pancreatic enzyme secretion 2- to 4-fold.	Bilirubin	155-164	cholecystokinin	Homo sapiens	12-15
1996640-3	1991	Infusion of loxiglumide (10 mg.kg-1.h-1 iv) abolished CCK-8-stimulated enzyme and bilirubin output.	Bilirubin	82-91	cholecystokinin	Homo sapiens	54-57
1898728-1	1991	We report the isolation and characterization of two human liver cDNA clones, HUG-Br1 and HUG-Br2; each encodes a UDP-glucuronosyltransferase enzyme which glucuronidates bilirubin IX alpha to form both the IX alpha C8 and IX alpha C12 monoconjugates and a diconjugate.	Bilirubin	169-178	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	77-84
1898728-1	1991	We report the isolation and characterization of two human liver cDNA clones, HUG-Br1 and HUG-Br2; each encodes a UDP-glucuronosyltransferase enzyme which glucuronidates bilirubin IX alpha to form both the IX alpha C8 and IX alpha C12 monoconjugates and a diconjugate.	Bilirubin	169-178	ciliogenesis and planar polarity effector complex subunit 1	Homo sapiens	77-80
2038668-3	1991	(2) Following hepatic damage induced by CCl4 (50%, 5 ml/kg), the levels of serum bilirubin and sGPT in PHR were significantly lower than those in sham operated rats.	Bilirubin	81-90	C-C motif chemokine ligand 4	Rattus norvegicus	40-44
2038668-5	1991	(3) Respiratory activity of regenerating liver mitochondria in PHR with or without CCl4 poisoning was higher than that in sham operated rats, and the respiratory activity went parallel with the degree of repair of histological damage, the reduction of serum bilirubin, sGPT and mortality.	Bilirubin	258-267	C-C motif chemokine ligand 4	Rattus norvegicus	83-87
1673394-6	1991	In addition, purified human liver UDPGT did not catalyze the glucuronidation of cholate, deoxycholate, chenodeoxycholate, ursodeoxycholate, lithocholate, hyocholate, hyodeoxycholate, bilirubin, morphine, or 4-hydroxybiphenyl.	Bilirubin	183-192	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	34-39
1878735-5	1991	The GM-CSF group had lower haemoglobin concentrations and platelets counts, and higher plasma urea creatinine and bilirubin, than the placebo group.	Bilirubin	114-123	colony stimulating factor 2	Homo sapiens	4-10
1804641-6	1991	Blood M19 was significantly correlated with bilirubin concentration and gamma-glutamyl transferase activity in serum, and M1A with the serum bilirubin concentration.	Bilirubin	44-53	ubiquinol-cytochrome c reductase complex assembly factor 2	Homo sapiens	6-9
1804641-6	1991	Blood M19 was significantly correlated with bilirubin concentration and gamma-glutamyl transferase activity in serum, and M1A with the serum bilirubin concentration.	Bilirubin	141-150	ubiquinol-cytochrome c reductase complex assembly factor 2	Homo sapiens	6-9
1823944-6	1991	The chemical structure of the natural ligand, or ligands, of ApoD in normal cells in vivo or in culture is not known, but ApoD has been shown to bind some steroids and bilirubin.	Bilirubin	168-177	apolipoprotein D	Homo sapiens	122-126
1648652-6	1991	It is found that the important HSA binding site for the heme breakdown product, bilirubin-IX alpha, is a target for these agents and is the site of highest relaxivity for all the agents.	Bilirubin	80-89	albumin	Homo sapiens	31-34
2027905-1	1991	Extraction of a solution of bilirubin configurational isomers in chloroform with an aqueous solution of human serum albumin was found to remove selectively the 4Z,15E-isomer.	Bilirubin	28-37	albumin	Homo sapiens	110-123
2027905-6	1991	An analysis of previously published data on the quantum yield for the formation of lumirubin from 4Z, 15Z-bilirubin bound to human serum albumin suggests that all of the formation of lumirubin may occur via consecutive photochemical processes with the 4E,15Z-isomer as an intermediate.	Bilirubin	106-115	albumin	Homo sapiens	131-144
1749222-2	1991	Bilirubin UDPGT activity, assayed by a microassay with HPLC analysis, was not detectable in type I livers, and low levels (9-26% of controls) of monoglucuronide conjugates only were observed in type II livers.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	10-15
1998214-2	1991	In 50 jaundiced babies who were ABO-incompatible it was found that the mean serum bilirubin level was significantly higher in outpatients than inpatients; this difference was probably due to the delay in recognizing jaundice among the outpatients and, possibly also to the slightly higher number of G-6-PD deficient babies in the same group, and their greater exposure to icterogenic agents.	Bilirubin	82-91	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	32-35
1998214-2	1991	In 50 jaundiced babies who were ABO-incompatible it was found that the mean serum bilirubin level was significantly higher in outpatients than inpatients; this difference was probably due to the delay in recognizing jaundice among the outpatients and, possibly also to the slightly higher number of G-6-PD deficient babies in the same group, and their greater exposure to icterogenic agents.	Bilirubin	82-91	glucose-6-phosphate dehydrogenase	Homo sapiens	299-305
2283667-7	1990	Administration of CCl4 produced elevations in ALT, moderate changes in bilirubin, and no change in ALP activities.	Bilirubin	71-80	C-C motif chemokine ligand 4	Rattus norvegicus	18-22
1987495-4	1991	Correlations were found between serum CAR-3 and (1) total bilirubin and (2) alkaline phosphatase.	Bilirubin	58-67	carbonic anhydrase 3	Homo sapiens	38-43
1978880-5	1990	The GM-CSF group had lower haemoglobin concentrations and platelet counts and higher plasma urea, creatinine, and bilirubin than the placebo group.	Bilirubin	114-123	colony stimulating factor 2	Homo sapiens	4-10
1708922-3	1991	During the early phase of each course of chemotherapy, AFP showed a temporary elevation associated with reversible increase in liver enzymes and bilirubin.	Bilirubin	145-154	alpha fetoprotein	Homo sapiens	55-58
2221093-1	1990	Bilirubin and phthalein dyes are taken up by the liver via a carrier-mediated mechanism operated at least in part by bilitranslocase (BTL).	Bilirubin	0-9	ceruloplasmin	Rattus norvegicus	117-132
2221093-1	1990	Bilirubin and phthalein dyes are taken up by the liver via a carrier-mediated mechanism operated at least in part by bilitranslocase (BTL).	Bilirubin	0-9	ceruloplasmin	Rattus norvegicus	134-137
2221093-7	1990	Competitive inhibition was observed with both unconjugated bilirubin (Ki, 2.9 +/- 0.2 microM) and rifamycin SV (Ki, 76 +/- 10 microM), known competitors for hepatic BTL-mediated transport of BSP.	Bilirubin	59-68	ceruloplasmin	Rattus norvegicus	165-168
2250393-4	1990	In patients with rising serum bilirubin, the serum C-12BMC/C-8BMC ratio was calculated to be as follows: 2.10 +/- 0.21 for FHF, 1.05 +/- 0.34 for AH and 0.81 +/- 0.08 for obstructive jaundice, respectively.	Bilirubin	30-39	fibroblast growth factor 12	Homo sapiens	123-129
2378896-1	1990	Biliverdin reductase (molecular form 1, EC 1.3.1.24, bilirubin:NAD(P)+ oxidoreductase) carries three thiol residues.	Bilirubin	53-62	thioredoxin reductase 1	Homo sapiens	71-85
2237261-7	1990	The results indicated that it is very likely that endogenous beta-glucuronidase plays a role in the deconjugation of bilirubin glucuronides as well as of other glucuronides in the intestine of the GF rat.	Bilirubin	117-126	glucuronidase, beta	Rattus norvegicus	61-79
1703124-0	1990	Interaction of human alpha fetoprotein with bilirubin.	Bilirubin	44-53	alpha fetoprotein	Homo sapiens	21-38
2174282-3	1990	Patients with serum bilirubin more than 10 mg/ml showed a higher serum TNF level than those with lower serum bilirubin.	Bilirubin	20-29	tumor necrosis factor	Homo sapiens	71-74
1703124-1	1990	Human alpha fetoprotein (AFP) binds bilirubin with an affinity somewhat lower than albumin.	Bilirubin	36-45	alpha fetoprotein	Homo sapiens	6-29
1696984-6	1990	This correlation between AFP level and prognosis was related to the fact that higher AFP values were associated with more severe inflammatory changes in the liver, as assessed from either biochemical parameters (peak total and direct bilirubin levels) or histological findings (portal inflammation and giant cell transformation.	Bilirubin	234-243	alpha fetoprotein	Homo sapiens	25-28
1696984-6	1990	This correlation between AFP level and prognosis was related to the fact that higher AFP values were associated with more severe inflammatory changes in the liver, as assessed from either biochemical parameters (peak total and direct bilirubin levels) or histological findings (portal inflammation and giant cell transformation.	Bilirubin	234-243	alpha fetoprotein	Homo sapiens	85-88
2113060-2	1990	Gunn rats lack UDP-glucuronosyltransferase (UDPGT) activity toward bilirubin.	Bilirubin	67-76	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	15-42
2113060-2	1990	Gunn rats lack UDP-glucuronosyltransferase (UDPGT) activity toward bilirubin.	Bilirubin	67-76	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	44-49
2113060-3	1990	4-Nitrophenol glucuronidation is mediated by several UDPGT isoforms that are distinct from bilirubin-UDPGT, one of which is induced after 3-methylcholanthrene (3-MC) administration in normal, but not in Gunn rats.	Bilirubin	91-100	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	101-106
2339855-8	1990	In patients with alcoholic hepatitis, tumor necrosis factor levels correlated positively with serum bilirubin (r = 0.74; P = 0.0009) and serum creatinine (r = 0.81; P = 0.0003).	Bilirubin	100-109	tumor necrosis factor	Homo sapiens	38-59
2364072-2	1990	Their reaction is shown to be affected by sulfobromophthalein, Thymol blue and bilirubin, which are translocated by bilitranslocase across the plasma membrane.	Bilirubin	79-88	ceruloplasmin	Rattus norvegicus	116-131
2112380-2	1990	Bilirubin UDPGT activity was demonstrated by transfection of the pcDL1 vector carrying the cDNA into COS7 monkey kidney cells.	Bilirubin	0-9	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	10-15
2186955-5	1990	Bilirubin derivatized with Woodward"s reagent K covalently bound to purified mucin.	Bilirubin	0-9	mucin 1, cell surface associated	Bos taurus	77-82
2186955-6	1990	Tryptic digestion of the mucin-bilirubin complex yielded low-molecular-weight nonglycosylated peptides with covalently bound bilirubin.	Bilirubin	31-40	mucin 1, cell surface associated	Bos taurus	25-30
2186955-6	1990	Tryptic digestion of the mucin-bilirubin complex yielded low-molecular-weight nonglycosylated peptides with covalently bound bilirubin.	Bilirubin	125-134	mucin 1, cell surface associated	Bos taurus	25-30
2103402-3	1990	Predrainage AP t1/2 correlated best with bilirubin clearance (r = 0.775, P less than 0.01) compared with predrainage serum bilirubin, alkaline phosphatase and serum proteins/albumin.	Bilirubin	41-50	lysophospholipase 1	Homo sapiens	12-19
1691530-10	1990	Albumin was found to be the primary predictor of over-all and hospital-free survival time and was a co-predictor of prolonged maintenance of low bilirubin levels along with biliary-enteric bypass.	Bilirubin	145-154	albumin	Homo sapiens	0-7
17977396-4	1990	Apolipoprotein A concentrations in plasma correlated positively with serum albumin (p &lt; 0.01) and negatively with serum bilirubin (p &lt; 0.01) and bile acids (p &lt; 0.01).	Bilirubin	123-132	lipoprotein(a)	Homo sapiens	0-16
1691530-13	1990	Albumin is a strong predictor of survival and maintenance of low bilirubin values and should be a major factor in deciding which patient should undergo a bypass procedure.	Bilirubin	65-74	albumin	Homo sapiens	0-7
2108190-5	1990	In liver microsomes from four patients (A, B, C, and D) with Crigler-Najjar syndrome type I (CN type I), UDPGT activity towards bilirubin was undetectable (A, B, C, and D) and activity towards phenolic compounds and 5-hydroxytryptamine either reduced (A and B) or normal (C and D).	Bilirubin	128-137	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	105-110
2324733-0	1990	Influence of aspirin and iron(III) tetrasulfonated phthalocyanine on bilirubin binding by human serum albumin.	Bilirubin	69-78	albumin	Homo sapiens	96-109
2324733-1	1990	The interaction of bilirubin with aspirin-modified human serum albumin (HSA) and the influence of iron tetrasulfonated phthalocyanine on bilirubin binding by the native protein has been studied by difference spectroscopy and circular dichroism measurements.	Bilirubin	19-28	albumin	Homo sapiens	57-70
2294965-0	1990	The sulfhydryl groups responsible for bilitranslocase transport activity respond to the interaction of the carrier with bilirubin and functional analogues.	Bilirubin	120-129	ceruloplasmin	Rattus norvegicus	38-53
2083249-5	1990	Preliminary experiments showed that purified human APO-D binds bilirubin in an approximately one-to-one molar ratio.	Bilirubin	63-72	apolipoprotein D	Homo sapiens	51-56
2294965-4	1990	The effect brought about by remarkably low concentrations of bilirubin is in line with the physiological function of bilitranslocase as a bilirubin carrier.	Bilirubin	61-70	ceruloplasmin	Rattus norvegicus	117-132
2294965-4	1990	The effect brought about by remarkably low concentrations of bilirubin is in line with the physiological function of bilitranslocase as a bilirubin carrier.	Bilirubin	138-147	ceruloplasmin	Rattus norvegicus	117-132
1979230-0	1990	Stereoselective effect of warfarin and bilirubin on the binding of 5-(o-chlorophenyl)-1,3-dihydro-3-methyl-7-nitro-2H-1,4-benzodiazepin-2- one enantiomers to human serum albumin.	Bilirubin	39-48	albumin	Homo sapiens	164-177
1983169-1	1990	Studies in the literature have shown the inhibitory action of bilirubin on serum gamma-glutamyl transpeptidase (GGT) activity.	Bilirubin	62-71	inactive glutathione hydrolase 2	Homo sapiens	81-110
2151809-4	1990	On the contrary, L-T3 accentuates the specific inductive effect of fibrates on bilirubin-UDPGT activity.	Bilirubin	79-88	UDP glucuronosyltransferase family 2 member B15	Rattus norvegicus	89-94
1979230-1	1990	The binding of the title benzodiazepine enantiomers and its modulation by warfarin and bilirubin were studied by chromatography on human serum albumin (HSA) immobilized on Sepharose 4B, and also by a combination of ultrafiltration and circular dichroism (UF-CD) methods.	Bilirubin	87-96	albumin	Homo sapiens	137-150
2304278-7	1990	Thus, hypersecretion of mucin, stimulated by prostaglandins, my participate in the onset and development of biliary tract infection or in the formation of calcium bilirubinate gallstones.	Bilirubin	155-175	LOC100508689	Homo sapiens	24-29
3902553-3	1985	Infusion of stepwise-increasing doses of CCK, ranging from 0.2 to 6.4 pmol/kg X h, induced dose-related increases in plasma CCK (r = 0.99; p less than 0.001), decreases in gallbladder volume (r = 0.99; p less than 0.001), and increases in intraduodenal bilirubin output (r = 0.96; p less than 0.01).	Bilirubin	253-262	cholecystokinin	Homo sapiens	41-44
2109806-4	1990	In patient with LC, the correlations between t-PA levels and serum total bilirubin (T.Bill) and hepatic synthetic functions were investigated.	Bilirubin	73-82	chromosome 20 open reading frame 181	Homo sapiens	45-49
3902553-5	1985	Infusion of 0.8 pmol/kg X h of CCK, resulting in an increase in plasma CCK of 1.3 +/- 0.5 pmol/L, was the threshold for stimulating gallbladder contraction as assessed by both ultrasonography and measurement of intraduodenal bilirubin output.	Bilirubin	225-234	cholecystokinin	Homo sapiens	31-34
3902553-5	1985	Infusion of 0.8 pmol/kg X h of CCK, resulting in an increase in plasma CCK of 1.3 +/- 0.5 pmol/L, was the threshold for stimulating gallbladder contraction as assessed by both ultrasonography and measurement of intraduodenal bilirubin output.	Bilirubin	225-234	cholecystokinin	Homo sapiens	71-74
32796590-2	2020	Normally, unconjugated bilirubin enters hepatocytes through the uptake transporters organic anion transporting polypeptide (OATP) 1B1 and 1B3, undergoes glucuronidation by the Phase II enzyme UDP glucuronosyltransferase 1A1 (UGT1A1), and conjugated forms are excreted into the bile by the canalicular export pump multidrug resistance protein 2 (MRP2).	Bilirubin	23-32	solute carrier organic anion transporter family member 1B1	Homo sapiens	84-141
33805292-4	2021	We systematically reviewed published evidence on HMOX1 polymorphisms in perinatal diseases and clarified their possible significant contribution to neonatal jaundice development, presumably due to their direct effect of inducing HO enzymatic activity in the bilirubin-producing pathway.	Bilirubin	258-267	heme oxygenase 1	Homo sapiens	49-54
33805158-11	2021	We found an association between positive reactivity of autoantibodies directed against components of PML nuclear bodies and higher concentrations of bilirubin and alkaline phosphatase, but the main prognostic marker of survival remains serum bilirubin.	Bilirubin	149-158	PML nuclear body scaffold	Homo sapiens	101-104
33762933-16	2021	Our findings show that hyperbilirubinemia is associated with reduced fat mass, and increased hepatic mitochondrial biogenesis, specifically in female animals, suggesting a dual role of elevated bilirubin and reduced UGT1A1 function on adiposity and body composition.	Bilirubin	28-37	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	216-222
33587911-4	2021	In the future, heme oxygenase-1 (HO-1) may also become a candidate ILD biomarker; it is a 32-kDa heat shock protein converting heme to carbon monoxide, biliverdin/bilirubin, and free iron to play a role in the pulmonary cytoprotective reaction in response to various stimuli.	Bilirubin	163-172	heme oxygenase 1	Homo sapiens	15-31
33587911-4	2021	In the future, heme oxygenase-1 (HO-1) may also become a candidate ILD biomarker; it is a 32-kDa heat shock protein converting heme to carbon monoxide, biliverdin/bilirubin, and free iron to play a role in the pulmonary cytoprotective reaction in response to various stimuli.	Bilirubin	163-172	heme oxygenase 1	Homo sapiens	33-37
33972830-7	2021	Comparison of HCC patients with high (>2.5 mg/ dL) compared low serum CRP levels showed significant differences for blood levels of NLR, LMR, Hb, total bilirubin and liver transaminases, as well as Maximum Tumor Diameter (MTD) and percent of patients with Portal Vein Thrombosis (PVT).	Bilirubin	152-161	C-reactive protein	Homo sapiens	70-73
32796590-2	2020	Normally, unconjugated bilirubin enters hepatocytes through the uptake transporters organic anion transporting polypeptide (OATP) 1B1 and 1B3, undergoes glucuronidation by the Phase II enzyme UDP glucuronosyltransferase 1A1 (UGT1A1), and conjugated forms are excreted into the bile by the canalicular export pump multidrug resistance protein 2 (MRP2).	Bilirubin	23-32	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	192-223
32796590-2	2020	Normally, unconjugated bilirubin enters hepatocytes through the uptake transporters organic anion transporting polypeptide (OATP) 1B1 and 1B3, undergoes glucuronidation by the Phase II enzyme UDP glucuronosyltransferase 1A1 (UGT1A1), and conjugated forms are excreted into the bile by the canalicular export pump multidrug resistance protein 2 (MRP2).	Bilirubin	23-32	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	225-231
32796590-2	2020	Normally, unconjugated bilirubin enters hepatocytes through the uptake transporters organic anion transporting polypeptide (OATP) 1B1 and 1B3, undergoes glucuronidation by the Phase II enzyme UDP glucuronosyltransferase 1A1 (UGT1A1), and conjugated forms are excreted into the bile by the canalicular export pump multidrug resistance protein 2 (MRP2).	Bilirubin	23-32	ATP binding cassette subfamily C member 2	Homo sapiens	313-343
32796590-2	2020	Normally, unconjugated bilirubin enters hepatocytes through the uptake transporters organic anion transporting polypeptide (OATP) 1B1 and 1B3, undergoes glucuronidation by the Phase II enzyme UDP glucuronosyltransferase 1A1 (UGT1A1), and conjugated forms are excreted into the bile by the canalicular export pump multidrug resistance protein 2 (MRP2).	Bilirubin	23-32	ATP binding cassette subfamily C member 2	Homo sapiens	345-349
32796590-3	2020	Any remaining conjugated bilirubin is transported back to the blood by MRP3 and passed on for uptake and excretion by downstream hepatocytes or the kidney.	Bilirubin	25-34	ATP binding cassette subfamily C member 3	Homo sapiens	71-75
32796590-4	2020	The bile salt export pump BSEP as the main motor of bile flow is indirectly involved in bilirubin disposition.	Bilirubin	88-97	ATP binding cassette subfamily B member 11	Homo sapiens	26-30
19229472-6	2009	Osteoprotegerin was more elevated in patients with more advanced disease, as defined by bilirubin above 1.2 mg/dl (6.6 +/- 0.6 vs. 5.2 +/- 0.2 pM/l, P = 0.02) or by Mayo over 4 (5.9 +/- 0.3 vs. 4.8 +/- 0.2 pM/l, P = 0.02).	Bilirubin	88-97	TNF receptor superfamily member 11b	Homo sapiens	0-15
33033449-0	2020	Newborns bilirubin concentration determined by different methods in relation to hematocrit and albumin level.	Bilirubin	9-18	albumin	Homo sapiens	95-102
33033449-4	2020	The study aimed to compare dry chemistry methods with vanadate oxidation method for bilirubin determination in relation to hematocrit and albumin level in neonates and infants.	Bilirubin	84-93	albumin	Homo sapiens	138-145
22325916-0	2012	Impact of UGT1A1 gene variants on total bilirubin levels in Gilbert syndrome patients and in healthy subjects.	Bilirubin	40-49	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	10-16
22325916-2	2012	This work investigated the effect of UGT1A1 variants on total bilirubin levels in Gilbert patients (n=45) and healthy controls (n=161).	Bilirubin	62-71	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	37-43
22325916-12	2012	Alterations in the UGT1A1 coding region seem to be associated with increased bilirubin levels, and, therefore, with Gilbert syndrome.	Bilirubin	77-86	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	19-25
18499754-4	2008	A possible candidate is OATP1B1 because model substrates for this transporter include the bilirubin mimic bromosulfophthalein (BSP) and E1S, and it is highly and specifically expressed in liver.	Bilirubin	90-99	solute carrier organic anion transporter family member 1B1	Homo sapiens	24-31
18499754-6	2008	Two Caucasian populations (155 blood donors and 1012 participants of the Rotterdam Scan Study) were genotyped for the OATP1B1-Val174Ala polymorphism and associated with bilirubin, E1S, and T4S levels.	Bilirubin	169-178	solute carrier organic anion transporter family member 1B1	Homo sapiens	118-125
18499754-10	2008	Carriers of the OATP1B1-Ala174 allele had higher serum bilirubin, E1S, and T4S levels.	Bilirubin	55-64	solute carrier organic anion transporter family member 1B1	Homo sapiens	16-23
18499754-11	2008	In conclusion, OATP1B1 is an important factor in hepatic transport and metabolism of bilirubin, E1S, and iodothyronine sulfates.	Bilirubin	85-94	solute carrier organic anion transporter family member 1B1	Homo sapiens	15-22
18499754-12	2008	OATP1B1-Ala174 displays decreased transport activity and thereby gives rise to higher bilirubin, E1S, and T4S levels in carriers of this polymorphism.	Bilirubin	86-95	solute carrier organic anion transporter family member 1B1	Homo sapiens	0-7
1339448-0	1992	A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.	Bilirubin	41-50	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	22-26
34863556-7	2022	Moreover, TinPPIX further augments the free heme level along with amplifies the CDT efficacy by disabling heme oxygenase-1 (HO-1)-mediated heme conversion into antioxidative bilirubin.	Bilirubin	174-183	heme oxygenase 1	Homo sapiens	106-122
34863556-7	2022	Moreover, TinPPIX further augments the free heme level along with amplifies the CDT efficacy by disabling heme oxygenase-1 (HO-1)-mediated heme conversion into antioxidative bilirubin.	Bilirubin	174-183	heme oxygenase 1	Homo sapiens	124-128
34840055-1	2022	Albumin is the most abundant serum protein that transports hormones, free fatty acids, bilirubin, various ions, and drugs.	Bilirubin	87-96	albumin	Homo sapiens	0-7
34767833-7	2022	Co-administration of ILM along with CCl4 to rat revert the level of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and total bilirubin in blood serum and antioxidant parameters in liver.	Bilirubin	163-172	C-C motif chemokine ligand 4	Rattus norvegicus	36-40
34625956-5	2022	We used a common variant in UGT1A1 (rs6742078) associated with an 26% increase in bilirubin levels in the genetic studies.	Bilirubin	82-91	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	28-34
34358403-0	2022	Neuroglobin expression and function in the temporal cortex of bilirubin encephalopathy rats.	Bilirubin	62-71	neuroglobin	Rattus norvegicus	0-11
34467453-4	2022	RESULTS: There was a significant positive correlation between LSR and albumin (rho = 0.193; p < 0.001), platelet counts (rho = 0.148; p = 0.004), and sodium (rho = 0.161; p = 0.002); and a negative correlation between LSR and total bilirubin (rho = -0.215; p < 0.001) and AST (rho = -0.191; p < 0.001).	Bilirubin	232-241	lipolysis stimulated lipoprotein receptor	Homo sapiens	218-221
34453252-12	2022	Results showed that CCl4 treatment (group II) elevated the levels of different serum markers like aspartate aminotransferase (AST) by 4.74 fold, alanine aminotransferase (ALT) by 3.47 fold, aspartate alkaline phosphatase (ALP) by 3.55 fold, direct bilirubin by 3.48 fold, and total bilirubin by 2.38 fold in contrast to control.	Bilirubin	248-257	C-C motif chemokine ligand 4	Rattus norvegicus	20-24
34689987-14	2022	CONCLUSION: We found a statistically significant positive correlation between CK and liver enzymes in rhabdomyolysis war wounded, indicating that hepatic damage occurs when rhabdomyolysis is severe and associated with elevated bilirubin and ALP.	Bilirubin	227-236	cytidine/uridine monophosphate kinase 1	Homo sapiens	78-80
34453252-12	2022	Results showed that CCl4 treatment (group II) elevated the levels of different serum markers like aspartate aminotransferase (AST) by 4.74 fold, alanine aminotransferase (ALT) by 3.47 fold, aspartate alkaline phosphatase (ALP) by 3.55 fold, direct bilirubin by 3.48 fold, and total bilirubin by 2.38 fold in contrast to control.	Bilirubin	282-291	C-C motif chemokine ligand 4	Rattus norvegicus	20-24
34841438-1	2022	Heme oxygenase-1 (HO-1) is an inducible cytoprotective enzyme that degrades heme into free iron, carbon monoxide and biliverdin, which is then rapidly converted into bilirubin.	Bilirubin	166-175	heme oxygenase 1	Homo sapiens	0-16
34841438-1	2022	Heme oxygenase-1 (HO-1) is an inducible cytoprotective enzyme that degrades heme into free iron, carbon monoxide and biliverdin, which is then rapidly converted into bilirubin.	Bilirubin	166-175	heme oxygenase 1	Homo sapiens	18-22
34823065-5	2022	Human variants of the mitochondrial transporter ABCB10, which regulates redox by increasing bilirubin synthesis, are associated with elevated T2D risk.	Bilirubin	92-101	ATP binding cassette subfamily B member 10	Homo sapiens	48-54
34823065-15	2022	Finally, ex-vivo and short-term deletion of Abcb10 in islets isolated from HFD-fed mice increased H2O2 and GSIS, which was reversed by bilirubin treatments.	Bilirubin	135-144	ATP-binding cassette, sub-family B (MDR/TAP), member 10	Mus musculus	44-50
34928467-3	2021	This study aimed to investigate the predictive value of the total bilirubin level, a marker of heme oxygenase-1 enzyme activity, in determining myocarditis in patients with COVID-19.	Bilirubin	66-75	heme oxygenase 1	Homo sapiens	95-111
34973332-5	2022	By measuring labile heme, total heme, and bilirubin in human embryonic kidney HEK293 cells with silenced or over-expressed HO-2, as well as various HO-2 mutant alleles, we found that endogenous heme is too limiting a substrate to observe HO-2-dependent heme degradation.	Bilirubin	42-51	heme oxygenase 2	Homo sapiens	238-242
34933608-5	2021	In the Gilbert syndrome group, total bilirubin level was negatively correlated with LVMI (r = -0246; P = .007) and endocan levels (r = -.270; P = .046).	Bilirubin	37-46	endothelial cell specific molecule 1	Homo sapiens	115-122
34942439-0	2022	Assessment of the albumin-bilirubin grade as a prognostic factor in patients with non-small-cell lung cancer receiving anti-PD-1-based therapy.	Bilirubin	26-35	programmed cell death 1	Homo sapiens	124-128
34940645-10	2021	Bifidobacteriaceae may act preventatively because of their suppressive effect on beta-glucuronidase, leading to accelerated deconjugation of conjugated bilirubin in the intestine.	Bilirubin	152-161	glucuronidase beta	Homo sapiens	81-99
34929150-13	2022	HSP47-C also correlated with other liver disease parameters, albumin, bilirubin and aspartate transaminase.	Bilirubin	70-79	serpin family H member 1	Homo sapiens	0-7
34956888-0	2021	Prediction Efficacy of Prognostic Nutritional Index and Albumin-Bilirubin Grade in Patients With Intrahepatic Cholangiocarcinoma After Radical Resection: A Multi-Institutional Analysis of 535 Patients.	Bilirubin	64-73	albumin	Homo sapiens	56-63
34943103-2	2021	The aim of our study was to assess the role of bilirubin, and the heme oxygenase 1 (HMOX1) and bilirubin UDP-glucuronosyl transferase (UGT1A1) promoter gene variants, which are involved in bilirubin homeostasis, in the NAFLD development in adult patients.	Bilirubin	95-104	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	135-141
34943103-2	2021	The aim of our study was to assess the role of bilirubin, and the heme oxygenase 1 (HMOX1) and bilirubin UDP-glucuronosyl transferase (UGT1A1) promoter gene variants, which are involved in bilirubin homeostasis, in the NAFLD development in adult patients.	Bilirubin	189-198	heme oxygenase 1	Homo sapiens	66-82
34943103-2	2021	The aim of our study was to assess the role of bilirubin, and the heme oxygenase 1 (HMOX1) and bilirubin UDP-glucuronosyl transferase (UGT1A1) promoter gene variants, which are involved in bilirubin homeostasis, in the NAFLD development in adult patients.	Bilirubin	189-198	heme oxygenase 1	Homo sapiens	84-89
34943103-2	2021	The aim of our study was to assess the role of bilirubin, and the heme oxygenase 1 (HMOX1) and bilirubin UDP-glucuronosyl transferase (UGT1A1) promoter gene variants, which are involved in bilirubin homeostasis, in the NAFLD development in adult patients.	Bilirubin	189-198	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	135-141
34907118-5	2022	RESULTS: HBP was significantly higher in patients with sepsis and was positively correlated to PCT and C-reactive protein, absolute neutrophil and monocyte counts, creatinine, bilirubin and lactate.	Bilirubin	176-185	azurocidin 1	Homo sapiens	9-12
34895177-2	2021	OBJECTIVE: To investigate the association between neonatal hyperbilirubinemia and co-inheritance of G6PD deficiency and 211 G to A variation of UGT1A1 in Chaozhou city of eastern Guangdong province, the effects of G6PD deficiency and UGT1A1 gene variant on the bilirubin level were determined in neonates with hyperbilirubinemia.	Bilirubin	261-270	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	144-150
34895177-2	2021	OBJECTIVE: To investigate the association between neonatal hyperbilirubinemia and co-inheritance of G6PD deficiency and 211 G to A variation of UGT1A1 in Chaozhou city of eastern Guangdong province, the effects of G6PD deficiency and UGT1A1 gene variant on the bilirubin level were determined in neonates with hyperbilirubinemia.	Bilirubin	261-270	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	234-240
34956888-2	2021	This study aimed to investigate whether prognostic nutritional index (PNI) + albumin-bilirubin (ALBI) could be a better predictor than PNI and ALBI alone in patients with ICC after radical resection.	Bilirubin	85-94	albumin	Homo sapiens	77-84
34546486-8	2021	Apart from structure similarities, our data revealed the strongest interaction of zebrafish Oatp2b1 with bile acids, steroid sulfates, thyroid hormones, and bilirubin, as well as xenobiotics bromosulfophthalein and sulfasalazine, which indicates its functional orthology with human OATP2B1.	Bilirubin	157-166	solute carrier organic anion transporter family, member 2B1	Danio rerio	92-99
34865514-7	2022	Circulating FGF21 levels were correlated with BNP (B-type natriuretic peptide) and total bilirubin, markers of chronic cardiac and hepatic congestion.	Bilirubin	89-98	fibroblast growth factor 21	Homo sapiens	12-17
34649153-9	2021	The biochemical analysis results showed that the lower liver function biomarker values (ALT, AST, ALP, total bilirubin and GGT) has gone for the Vit-E/C@SeNPs prevention and treated group, which also showed significant depletion of liver tissue l-MDA, and obvious increase in GSH concentration and CAT activity and marked improvement in the histological feature of liver tissue.	Bilirubin	109-118	vitrin	Rattus norvegicus	145-148
34216018-4	2021	We identified a genetic locus in mitochondrial glycerol-3-phosphate acyltransferase (GPAM rs10787429) associated with increased levels of ALT (P=1.4x10-30 ), AST (P=3.6x10-10 ), ALP (P=9.5x10-30 ) and total bilirubin (P=2.9x10-12 ).	Bilirubin	207-216	glycerol-3-phosphate acyltransferase, mitochondrial	Homo sapiens	85-89
34425063-6	2021	MATERIALS AND METHODS: Bilirubin was incorporated into beta-CD-based inclusion complex (BR/beta-CD) which was then loaded into a bioadhesive hydrogel matrix (BR/beta-CD/SGP).	Bilirubin	23-32	ACD, shelterin complex subunit and telomerase recruitment factor	Rattus norvegicus	55-62
34425063-6	2021	MATERIALS AND METHODS: Bilirubin was incorporated into beta-CD-based inclusion complex (BR/beta-CD) which was then loaded into a bioadhesive hydrogel matrix (BR/beta-CD/SGP).	Bilirubin	23-32	ACD, shelterin complex subunit and telomerase recruitment factor	Rattus norvegicus	91-98
34425063-9	2021	Histological assays were conducted to evaluate the in vivo effect of BR/beta-CD/SGP.	Bilirubin	69-71	ACD, shelterin complex subunit and telomerase recruitment factor	Rattus norvegicus	72-79
34425063-13	2021	The therapeutic effects of BR/beta-CD/SGP were much better than those of the BR group.	Bilirubin	27-29	ACD, shelterin complex subunit and telomerase recruitment factor	Rattus norvegicus	30-41
34880749-4	2021	DE activates an important regulator of bilirubin metabolism, the constitutive androstane receptor (CAR), and increases bilirubin clearance.	Bilirubin	39-48	nuclear receptor subfamily 1, group I, member 3	Mus musculus	65-97
34807779-1	2022	UDP-glucuronyltransferase 1A1 (UGT1A1) is a member of the Phase II metabolic enzyme family and the only enzyme that can metabolize detoxified bilirubin.	Bilirubin	142-151	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-29
34807779-1	2022	UDP-glucuronyltransferase 1A1 (UGT1A1) is a member of the Phase II metabolic enzyme family and the only enzyme that can metabolize detoxified bilirubin.	Bilirubin	142-151	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	31-37
34880749-12	2021	These results identify a potential CAR-mediated mechanism by which DE regulates Cyp2a5 gene expression and suggests that DE may enhance bilirubin clearance by increasing Cyp2a5 levels.	Bilirubin	136-145	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	170-176
34880749-4	2021	DE activates an important regulator of bilirubin metabolism, the constitutive androstane receptor (CAR), and increases bilirubin clearance.	Bilirubin	39-48	nuclear receptor subfamily 1, group I, member 3	Mus musculus	99-102
34880749-5	2021	In addition, murine cytochrome P450 2a5 (Cyp2a5) is known to be involved in the oxidative metabolism of bilirubin.	Bilirubin	104-113	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	20-39
34880749-5	2021	In addition, murine cytochrome P450 2a5 (Cyp2a5) is known to be involved in the oxidative metabolism of bilirubin.	Bilirubin	104-113	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	41-47
34880749-12	2021	These results identify a potential CAR-mediated mechanism by which DE regulates Cyp2a5 gene expression and suggests that DE may enhance bilirubin clearance by increasing Cyp2a5 levels.	Bilirubin	136-145	nuclear receptor subfamily 1, group I, member 3	Mus musculus	35-38
34880749-12	2021	These results identify a potential CAR-mediated mechanism by which DE regulates Cyp2a5 gene expression and suggests that DE may enhance bilirubin clearance by increasing Cyp2a5 levels.	Bilirubin	136-145	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	80-86
34535815-4	2021	Gold nanoclusters capped by human serum albumin (HSA-AuNCs) were utilized as a fluorescent platform for bilirubin biorecognition.	Bilirubin	104-113	albumin	Homo sapiens	34-47
2116906-13	1990	Finally, significant correlations were observed between glucuronidation of bilirubin and 4-nitrophenol and the content in cytochrome P-450.	Bilirubin	75-84	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	122-138
34861454-6	2021	On day 3, the biochemical analysis showed a higher level of albumin for ET-derived males, and a lower level of bilirubin for ET-females than AI controls.	Bilirubin	111-120	major facilitator superfamily domain containing 11	Homo sapiens	125-127
34789221-10	2021	RESULTS: Exposure to CCl4 and rifampicin respectively resulted in marked distortion in lipid profile, inhibition of antioxidant enzymes and a surge in ALT, AST, ALP, urea, uric acid, bilirubin and creatine kinase.	Bilirubin	183-192	C-C motif chemokine ligand 4	Rattus norvegicus	21-25
34866848-2	2021	In most cases, GS is associated with the UGT1A1*28 polymorphism of UGT1A1 gene coding the enzyme bilirubin uridine diphosphate glucuronosyltransferase (UGT-1A) which plays a key role in the bilirubin metabolism.	Bilirubin	97-106	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	41-47
34543755-0	2021	Discovery of bilirubin as novel P2X7R antagonist with anti-tumor activity.	Bilirubin	13-22	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	32-37
34543755-7	2021	In this study, we identified bilirubin as novel P2X7R antagonist by using structure based virtual screening combined with cell based assays.	Bilirubin	29-38	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	48-53
34543755-8	2021	Molecular docking studies indicated that bilirubin probably interacted with P2X7R by forming hydrogen-pi interactions with residues V173, E174 and K311.	Bilirubin	41-50	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	76-81
34543755-9	2021	The compound bilirubin inhibited the P2X7R gated EB intake by cancer cells.	Bilirubin	13-22	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	37-42
34543755-10	2021	Meanwhile, bilirubin was capable to inhibit the cell proliferation and migration of P2X7R expressed HT29 cells.	Bilirubin	11-20	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	84-89
34543755-11	2021	The phosphorylation of mTOR, STAT3 and GSK3beta were significantly decreased when bilirubin was present.	Bilirubin	82-91	mechanistic target of rapamycin kinase	Homo sapiens	23-27
34543755-11	2021	The phosphorylation of mTOR, STAT3 and GSK3beta were significantly decreased when bilirubin was present.	Bilirubin	82-91	signal transducer and activator of transcription 3	Homo sapiens	29-34
34543755-11	2021	The phosphorylation of mTOR, STAT3 and GSK3beta were significantly decreased when bilirubin was present.	Bilirubin	82-91	glycogen synthase kinase 3 alpha	Homo sapiens	39-47
34543755-13	2021	In conclusion, bilirubin was identified as a novel P2X7R antagonist and it may have potential for anti-cancer treatment, although various functions of the molecule should be considered.	Bilirubin	15-24	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	51-56
34837908-6	2021	There was a correlation between serum CEACAM1 level and total bilirubin, and direct bilirubin.	Bilirubin	62-71	CEA cell adhesion molecule 1	Homo sapiens	38-45
34837908-6	2021	There was a correlation between serum CEACAM1 level and total bilirubin, and direct bilirubin.	Bilirubin	84-93	CEA cell adhesion molecule 1	Homo sapiens	38-45
34866848-2	2021	In most cases, GS is associated with the UGT1A1*28 polymorphism of UGT1A1 gene coding the enzyme bilirubin uridine diphosphate glucuronosyltransferase (UGT-1A) which plays a key role in the bilirubin metabolism.	Bilirubin	97-106	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	67-73
34866848-2	2021	In most cases, GS is associated with the UGT1A1*28 polymorphism of UGT1A1 gene coding the enzyme bilirubin uridine diphosphate glucuronosyltransferase (UGT-1A) which plays a key role in the bilirubin metabolism.	Bilirubin	97-106	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	152-158
34866848-2	2021	In most cases, GS is associated with the UGT1A1*28 polymorphism of UGT1A1 gene coding the enzyme bilirubin uridine diphosphate glucuronosyltransferase (UGT-1A) which plays a key role in the bilirubin metabolism.	Bilirubin	190-199	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	41-47
34866848-2	2021	In most cases, GS is associated with the UGT1A1*28 polymorphism of UGT1A1 gene coding the enzyme bilirubin uridine diphosphate glucuronosyltransferase (UGT-1A) which plays a key role in the bilirubin metabolism.	Bilirubin	190-199	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	67-73
34866848-2	2021	In most cases, GS is associated with the UGT1A1*28 polymorphism of UGT1A1 gene coding the enzyme bilirubin uridine diphosphate glucuronosyltransferase (UGT-1A) which plays a key role in the bilirubin metabolism.	Bilirubin	190-199	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	152-158
34866848-7	2021	Conclusions: Despite the fact that the level of serum bilirubin increases with the rise in the number of additional TA dinucleotides in the UGT1A1 gene promoter tests of clinical manifestations only (jaundice, fatigue, sleep disturbances, nausea, belching, and so on) and increased bilirubin levels in patients with normal liver function do not allow unequivocally diagnose GS.	Bilirubin	54-63	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	140-146
34061255-12	2021	Urine NGAL positively correlated with total serum bilirubin (r = 0.575, P < 0.001).	Bilirubin	50-59	lipocalin 2	Homo sapiens	6-10
34610553-1	2021	BACKGROUND & AIMS: Plasma concentrations of bilirubin, a product of heme catabolism formed by biliverdin reductase A (BVRA), inversely associate with the risk of metabolic diseases including hepatic steatosis and diabetes mellitus in humans.	Bilirubin	44-53	biliverdin reductase A	Homo sapiens	94-116
34610553-1	2021	BACKGROUND & AIMS: Plasma concentrations of bilirubin, a product of heme catabolism formed by biliverdin reductase A (BVRA), inversely associate with the risk of metabolic diseases including hepatic steatosis and diabetes mellitus in humans.	Bilirubin	44-53	biliverdin reductase A	Homo sapiens	118-122
34610553-2	2021	Bilirubin has antioxidant and anti-inflammatory activities and may also regulate insulin signaling and peroxisome proliferator-activated receptor alpha (PPARalpha) activity.	Bilirubin	0-9	insulin	Homo sapiens	81-88
34610553-2	2021	Bilirubin has antioxidant and anti-inflammatory activities and may also regulate insulin signaling and peroxisome proliferator-activated receptor alpha (PPARalpha) activity.	Bilirubin	0-9	peroxisome proliferator activated receptor alpha	Mus musculus	103-151
34610553-2	2021	Bilirubin has antioxidant and anti-inflammatory activities and may also regulate insulin signaling and peroxisome proliferator-activated receptor alpha (PPARalpha) activity.	Bilirubin	0-9	peroxisome proliferator activated receptor alpha	Mus musculus	153-162
34841762-0	2021	(The Role of Nrf2 Pathway Activation in Hippocampal Neuron Injury of Neonatal Rats with Bilirubin Encephalopathy).	Bilirubin	88-97	NFE2 like bZIP transcription factor 2	Rattus norvegicus	13-17
34841762-1	2021	Objective: To explore the effect of nuclear factor-erythroid 2-related factor (Nrf2) pathway activation on hippocampal neuron damage in neonatal rats with bilirubin encephalopathy.	Bilirubin	155-164	NFE2 like bZIP transcription factor 2	Rattus norvegicus	36-77
34841762-1	2021	Objective: To explore the effect of nuclear factor-erythroid 2-related factor (Nrf2) pathway activation on hippocampal neuron damage in neonatal rats with bilirubin encephalopathy.	Bilirubin	155-164	NFE2 like bZIP transcription factor 2	Rattus norvegicus	79-83
34841762-13	2021	Conclusion: Activation of the Nrf2 pathway can improve hippocampal neuronal damage in neonatal rats with bilirubin encephalopathy and inhibit neuronal apoptosis and the oxidation reaction.	Bilirubin	105-114	NFE2 like bZIP transcription factor 2	Rattus norvegicus	30-34
34757153-3	2022	published a first case of SLC10A1 mutation causing Na-taurocholate Co-transporting Polypeptide deficiency with hypercholanemia and normal bilirubin and Autotaxin levels.	Bilirubin	138-147	solute carrier family 10 member 1	Homo sapiens	26-33
34722177-8	2021	Correspondingly, in patients with improved PTA, these values for TB were 28.8%, 27.3%, and 43.9%, respectively.	Bilirubin	65-67	pre T cell antigen receptor alpha	Homo sapiens	43-46
34828911-10	2021	The results showed that bar consumption significantly decreased serum aspartate transaminase (AST) and lactate dehydrogenase (LDH) and increased total and direct bilirubin levels, suggesting lower exercise-induced muscle damage and increased antioxidative response, respectively.	Bilirubin	162-171	bifunctional apoptosis regulator	Homo sapiens	24-27
34686839-5	2022	The administration of unconjugated bilirubin (UCB) dramatically suppressed ILC2 responses to interleukin (IL)-33 in mice, including cell proliferation and the production of effector cytokines.	Bilirubin	35-44	interleukin 33	Mus musculus	93-112
34737578-6	2021	Hydrogen sulfide (H2S) likewise opposes mast cell activation; H2S can boost AMPK activity, up-regulate cGMP production, and trigger Nrf2-mediated induction of Phase 2 enzymes - including heme oxygenase-1, whose generation of bilirubin suppresses NADPH oxidase activity.	Bilirubin	225-234	NFE2 like bZIP transcription factor 2	Homo sapiens	132-136
34737578-6	2021	Hydrogen sulfide (H2S) likewise opposes mast cell activation; H2S can boost AMPK activity, up-regulate cGMP production, and trigger Nrf2-mediated induction of Phase 2 enzymes - including heme oxygenase-1, whose generation of bilirubin suppresses NADPH oxidase activity.	Bilirubin	225-234	heme oxygenase 1	Homo sapiens	187-203
34744762-5	2021	L-PGDS binds retinoic acids and retinal with high affinities (Kd < 100 nM) and diverse small lipophilic substances, such as thyroids, gangliosides, bilirubin and biliverdin, heme, NAD(P)H, and PGD2, acting as an extracellular carrier of these substances.	Bilirubin	148-157	prostaglandin D2 synthase	Homo sapiens	0-6
34924900-4	2021	Bilirubin concentration was measured by HPLC and molecular docking was performed to identify an appropriate inhibitor for BVR-A.	Bilirubin	0-9	biliverdin reductase A	Homo sapiens	122-127
34814402-1	2021	Gilbert"s syndrome is a kind of benign inherited disease of bilirubin binding disorder, mainly due to the homozygous polymorphism A(TA)7TAA in the promoter of the gene for uridine diphosphate -glucuronosyltransferase 1A1 (UGT1A1), which is a TA insertion into the promoter, designated as UGT1A1*28, with UGT activity reduction to 30% of the normal value.	Bilirubin	60-69	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	172-220
34814402-1	2021	Gilbert"s syndrome is a kind of benign inherited disease of bilirubin binding disorder, mainly due to the homozygous polymorphism A(TA)7TAA in the promoter of the gene for uridine diphosphate -glucuronosyltransferase 1A1 (UGT1A1), which is a TA insertion into the promoter, designated as UGT1A1*28, with UGT activity reduction to 30% of the normal value.	Bilirubin	60-69	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	222-228
34814402-1	2021	Gilbert"s syndrome is a kind of benign inherited disease of bilirubin binding disorder, mainly due to the homozygous polymorphism A(TA)7TAA in the promoter of the gene for uridine diphosphate -glucuronosyltransferase 1A1 (UGT1A1), which is a TA insertion into the promoter, designated as UGT1A1*28, with UGT activity reduction to 30% of the normal value.	Bilirubin	60-69	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	288-294
34814402-1	2021	Gilbert"s syndrome is a kind of benign inherited disease of bilirubin binding disorder, mainly due to the homozygous polymorphism A(TA)7TAA in the promoter of the gene for uridine diphosphate -glucuronosyltransferase 1A1 (UGT1A1), which is a TA insertion into the promoter, designated as UGT1A1*28, with UGT activity reduction to 30% of the normal value.	Bilirubin	60-69	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	304-307
34621044-1	2022	BACKGROUND: Albumin-bilirubin (ALBI) grade is an objective measure of liver function for patients with hepatocellular carcinoma (HCC).	Bilirubin	20-29	albumin	Homo sapiens	12-19
34265290-9	2021	Either tricarbonyldichlororuthenium(II) dimer (CORM-2, a source of carbon monoxide - CO) or bilirubin (BR), that are products of the HO-1-biliverdin reductase (BVR) axis, blocked some of the effects caused by GLU in the SH-SY5Y cells.	Bilirubin	92-101	biliverdin reductase A	Homo sapiens	133-158
34265290-9	2021	Either tricarbonyldichlororuthenium(II) dimer (CORM-2, a source of carbon monoxide - CO) or bilirubin (BR), that are products of the HO-1-biliverdin reductase (BVR) axis, blocked some of the effects caused by GLU in the SH-SY5Y cells.	Bilirubin	92-101	biliverdin reductase A	Homo sapiens	160-163
34265290-9	2021	Either tricarbonyldichlororuthenium(II) dimer (CORM-2, a source of carbon monoxide - CO) or bilirubin (BR), that are products of the HO-1-biliverdin reductase (BVR) axis, blocked some of the effects caused by GLU in the SH-SY5Y cells.	Bilirubin	103-105	biliverdin reductase A	Homo sapiens	133-158
34265290-9	2021	Either tricarbonyldichlororuthenium(II) dimer (CORM-2, a source of carbon monoxide - CO) or bilirubin (BR), that are products of the HO-1-biliverdin reductase (BVR) axis, blocked some of the effects caused by GLU in the SH-SY5Y cells.	Bilirubin	103-105	biliverdin reductase A	Homo sapiens	160-163
34293961-10	2021	Meanwhile, administration of antioxidants or heme oxygenase-1 induction to elevate the hepatocellular levels of the endogenous scavenger bilirubin are promising alternatives that need to be re-evaluated and implemented.	Bilirubin	137-146	heme oxygenase 1	Homo sapiens	45-61
34686839-7	2022	Mechanistic studies showed that the effects of bilirubin on ILC2s were associated with downregulation of ERK phosphorylation and GATA3 expression.	Bilirubin	47-56	mitogen-activated protein kinase 1	Mus musculus	105-108
34686839-7	2022	Mechanistic studies showed that the effects of bilirubin on ILC2s were associated with downregulation of ERK phosphorylation and GATA3 expression.	Bilirubin	47-56	GATA binding protein 3	Mus musculus	129-134
34680437-0	2021	Bile Duct Ligation Upregulates Expression and Function of L-Amino Acid Transporter 1 at Blood-Brain Barrier of Rats via Activation of Aryl Hydrocarbon Receptor by Bilirubin.	Bilirubin	163-172	aryl hydrocarbon receptor	Rattus norvegicus	134-159
34260896-9	2021	CONCLUSIONS: Our findings provide answers to questions raised in the 2004 AAP bilirubin guidelines.	Bilirubin	78-87	serpin family F member 2	Homo sapiens	74-77
34680437-7	2021	Both aryl hydrocarbon receptor (AhR) antagonist alpha-naphthoflavone and AhR silencing obviously attenuated the upregulation of LAT1 protein by bilirubin or omeprazole.	Bilirubin	144-153	aryl hydrocarbon receptor	Rattus norvegicus	5-30
34680437-7	2021	Both aryl hydrocarbon receptor (AhR) antagonist alpha-naphthoflavone and AhR silencing obviously attenuated the upregulation of LAT1 protein by bilirubin or omeprazole.	Bilirubin	144-153	aryl hydrocarbon receptor	Rattus norvegicus	32-35
34680437-7	2021	Both aryl hydrocarbon receptor (AhR) antagonist alpha-naphthoflavone and AhR silencing obviously attenuated the upregulation of LAT1 protein by bilirubin or omeprazole.	Bilirubin	144-153	aryl hydrocarbon receptor	Rattus norvegicus	73-76
34680437-8	2021	This study provides the first evidence that BDL upregulates LAT1 at the rat BBB, attributed to the activation of AhR by the increased plasma bilirubin.	Bilirubin	141-150	aryl hydrocarbon receptor	Rattus norvegicus	113-116
34499923-5	2022	Recent reports indicate that HO-1 with its antioxidants via the effect of bilirubin increases formation of biologically active lipid metabolites such as epoxyeicosatrienoic acid (EET), omega-3 and other polyunsaturated fatty acids (PUFAs).	Bilirubin	74-83	heme oxygenase 1	Homo sapiens	29-33
34622191-4	2021	However, the mechanistic insights linking bilirubin-Fetuin-A, FGF23 and inflammation in patients with sepsis is poorly understood.	Bilirubin	42-51	alpha 2-HS glycoprotein	Homo sapiens	52-60
34622191-4	2021	However, the mechanistic insights linking bilirubin-Fetuin-A, FGF23 and inflammation in patients with sepsis is poorly understood.	Bilirubin	42-51	fibroblast growth factor 23	Homo sapiens	62-67
34548793-5	2021	The exclusion criteria are as follows: 1) age <18 years, 2) severe liver disease/cirrhosis, 3) received more than one type of PN and 4) serum total bilirubin >4.9 mg/dl at admission.	Bilirubin	148-157	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	126-134
34563210-2	2021	This study aimed to prospectively investigate the value of albumin-bilirubin grade (ALBI) in predicting IVIG resistance in KD and to assess whether ALBI has more predictive value or accuracy than either ALB or TBil alone in predicting IVIG resistance.	Bilirubin	67-76	albumin	Homo sapiens	59-66
34604277-10	2021	Hyper direct-bilirubin could be a surrogate marker of Mrp2 dysfunction, which results in metabolite accumulation.	Bilirubin	13-22	ATP binding cassette subfamily C member 2	Homo sapiens	54-58
34650714-6	2021	CONCLUSIONS: We found that GLP-2 can decrease the serum TGF-beta1 levels, regulate the immune function, reduce the endotoxin and bilirubin, and protect the intestinal barrier function in rats with obstructive jaundice.	Bilirubin	129-138	mast cell protease 10	Rattus norvegicus	27-32
34527681-4	2021	In this study, we aim to study the clinical significance of the indirect bilirubin-albumin ratio in HE.	Bilirubin	73-82	albumin	Homo sapiens	83-90
34714289-8	2021	Female sex, age younger than 50 years, a benign indication of ERCP, and low bilirubin levels have higher chances of PEP.	Bilirubin	76-85	prolyl endopeptidase	Homo sapiens	116-119
34573035-0	2021	Bilirubin Links HO-1 and UGT1A1*28 Gene Polymorphisms to Predict Cardiovascular Outcome in Patients Receiving Maintenance Hemodialysis.	Bilirubin	0-9	heme oxygenase 1	Homo sapiens	16-20
34573035-0	2021	Bilirubin Links HO-1 and UGT1A1*28 Gene Polymorphisms to Predict Cardiovascular Outcome in Patients Receiving Maintenance Hemodialysis.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	25-31
34224815-1	2021	Biliverdin reductase-A (BVR) catalyzes the reduction of heme-derived biliverdin into bilirubin, this latter being a powerful endogenous free radical scavenger.	Bilirubin	85-94	biliverdin reductase A	Homo sapiens	0-22
34573035-1	2021	Serum bilirubin levels, which are determined by a complex interplay of various enzymes, including heme oxygenase-1 (HO-1) and uridine diphosphate-glucuronosyl transferase (UGT1A1), may be protective against progression of cardiovascular disease (CVD) in hemodialysis patients.	Bilirubin	6-15	heme oxygenase 1	Homo sapiens	98-114
34573035-1	2021	Serum bilirubin levels, which are determined by a complex interplay of various enzymes, including heme oxygenase-1 (HO-1) and uridine diphosphate-glucuronosyl transferase (UGT1A1), may be protective against progression of cardiovascular disease (CVD) in hemodialysis patients.	Bilirubin	6-15	heme oxygenase 1	Homo sapiens	116-120
34573035-1	2021	Serum bilirubin levels, which are determined by a complex interplay of various enzymes, including heme oxygenase-1 (HO-1) and uridine diphosphate-glucuronosyl transferase (UGT1A1), may be protective against progression of cardiovascular disease (CVD) in hemodialysis patients.	Bilirubin	6-15	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	172-178
34573035-3	2021	This retrospective study enrolled 1080 prevalent hemodialysis patients and the combined genetic polymorphisms of HO-1 and UGT1A1 on serum bilirubin were analyzed.	Bilirubin	138-147	heme oxygenase 1	Homo sapiens	113-117
34573035-3	2021	This retrospective study enrolled 1080 prevalent hemodialysis patients and the combined genetic polymorphisms of HO-1 and UGT1A1 on serum bilirubin were analyzed.	Bilirubin	138-147	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	122-128
34573035-5	2021	Mean serum bilirubin was highest in patients with S/S + S/L of the HO-1 promoter and UGT1A1 7/7 genotypes (Group 1), intermediate in those with S/S + S/L of the HO-1 promoter and UGT1A1 7/6 + 6/6 genotypes (Group 2), and lowest in the carriers with the L/L HO-1 promoter and UGT1A1 7/6 + 6/6 genotypes (Group 3) (p < 0.001).	Bilirubin	11-20	heme oxygenase 1	Homo sapiens	67-71
34573035-5	2021	Mean serum bilirubin was highest in patients with S/S + S/L of the HO-1 promoter and UGT1A1 7/7 genotypes (Group 1), intermediate in those with S/S + S/L of the HO-1 promoter and UGT1A1 7/6 + 6/6 genotypes (Group 2), and lowest in the carriers with the L/L HO-1 promoter and UGT1A1 7/6 + 6/6 genotypes (Group 3) (p < 0.001).	Bilirubin	11-20	heme oxygenase 1	Homo sapiens	161-165
34477753-4	2021	In this work, endogenous bile pigments bilirubin (BR) and biliverdin (BV) were used for the first time to synthesize stimuli-responsive carbon dots (BR-CDots and BV-CDots respectively).	Bilirubin	39-48	chromosome 12 open reading frame 73	Homo sapiens	50-52
34477753-4	2021	In this work, endogenous bile pigments bilirubin (BR) and biliverdin (BV) were used for the first time to synthesize stimuli-responsive carbon dots (BR-CDots and BV-CDots respectively).	Bilirubin	39-48	chromosome 12 open reading frame 73	Homo sapiens	149-151
34477753-7	2021	Nanoparticle Tracking Analysis revealed that the hydrodynamic size of the BR-CDots and BV-CDots decreased with exposure to bilirubin oxidase and biliverdin reductase, respectively, indicating potential enzyme-responsive degradation of the carbon dots.	Bilirubin	123-132	chromosome 12 open reading frame 73	Homo sapiens	74-76
34427789-7	2022	Multivariate analyses revealed that the independent risk factors for postoperative complications were gastrectomy history, an albumin-bilirubin score of 2/3, primary liver cancer, high serum creatinine level, advanced age, and prolonged operation time.	Bilirubin	134-143	albumin	Homo sapiens	126-133
34224815-1	2021	Biliverdin reductase-A (BVR) catalyzes the reduction of heme-derived biliverdin into bilirubin, this latter being a powerful endogenous free radical scavenger.	Bilirubin	85-94	biliverdin reductase A	Homo sapiens	24-27
34404360-10	2021	Moreover, CFH level was moderately correlated with alkaline phosphatase (ALP) and slightly correlated with age, uric acid (UA) and total bilirubin (TB) in non-GDM (all P <  0.05).	Bilirubin	137-146	complement factor H	Homo sapiens	10-13
34483918-11	2021	Moreover, the end products of HO-1, namely, CO, Fe2+, and biliverdin (will converted to bilirubin), also decreases the expression of matrix metalloproteinase-9.	Bilirubin	88-97	heme oxygenase 1	Homo sapiens	30-34
34483918-11	2021	Moreover, the end products of HO-1, namely, CO, Fe2+, and biliverdin (will converted to bilirubin), also decreases the expression of matrix metalloproteinase-9.	Bilirubin	88-97	matrix metallopeptidase 9	Homo sapiens	133-159
34404360-10	2021	Moreover, CFH level was moderately correlated with alkaline phosphatase (ALP) and slightly correlated with age, uric acid (UA) and total bilirubin (TB) in non-GDM (all P <  0.05).	Bilirubin	148-150	complement factor H	Homo sapiens	10-13
34362525-8	2021	Compared with that of ABO-HDN patients, the total bilirubin of non ABO-HDN patients developed more rapidly with a higher peak and a longer duration (P<0.001).	Bilirubin	50-59	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	22-25
34085382-5	2021	Mechanistically, YZH significantly up-regulated the mRNA expression of genes involved in hepatic bilirubin disposition (organic anion-transporting polypeptide 1b2, Oatp1b2;  multidrug resistance-associated protein 2, Mrp2)  and bilirubin conjugation (UDP-glucuronosyltransferase 1a1, Ugt1a1) .	Bilirubin	97-106	ATP binding cassette subfamily C member 2	Rattus norvegicus	174-215
34085382-5	2021	Mechanistically, YZH significantly up-regulated the mRNA expression of genes involved in hepatic bilirubin disposition (organic anion-transporting polypeptide 1b2, Oatp1b2;  multidrug resistance-associated protein 2, Mrp2)  and bilirubin conjugation (UDP-glucuronosyltransferase 1a1, Ugt1a1) .	Bilirubin	97-106	ATP binding cassette subfamily C member 2	Rattus norvegicus	217-221
34362525-8	2021	Compared with that of ABO-HDN patients, the total bilirubin of non ABO-HDN patients developed more rapidly with a higher peak and a longer duration (P<0.001).	Bilirubin	50-59	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	67-70
34362525-12	2021	The peak value of bilirubin in non ABO-HDN patients is higher and lasts longer than that in ABO-HDN patients.	Bilirubin	18-27	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	35-38
34321584-0	2021	Author Correction: Combined prognostic nutritional index and albumin-bilirubin grade to predict the postoperative prognosis of HBV-associated hepatocellular carcinoma patients.	Bilirubin	69-78	albumin	Homo sapiens	61-68
34161994-4	2021	Recently, two research groups independently identified Mas-related G protein-coupled receptor X4 (MRGPRX4) as a receptor for bile acids and bilirubin and demonstrated its likely role in cholestatic itch.	Bilirubin	140-149	MAS related GPR family member X4	Homo sapiens	98-105
34161994-6	2021	In this review, we summarize the current theories and knowledge of cholestatic itch, emphasizing MRGPRX4 as a bile acid and bilirubin receptor mediating cholestatic itch in humans.	Bilirubin	124-133	MAS related GPR family member X4	Homo sapiens	97-104
34161994-4	2021	Recently, two research groups independently identified Mas-related G protein-coupled receptor X4 (MRGPRX4) as a receptor for bile acids and bilirubin and demonstrated its likely role in cholestatic itch.	Bilirubin	140-149	MAS related GPR family member X4	Homo sapiens	55-96
34373769-0	2021	Bilirubin Oxidation End Products (BOXes) Induce Neuronal Oxidative Stress Involving the Nrf2 Pathway.	Bilirubin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	88-92
34359658-0	2021	On-Treatment Albumin-Bilirubin Grade: Predictor of Response and Outcome of Sorafenib-Regorafenib Sequential Therapy in Patients with Unresectable Hepatocellular Carcinoma.	Bilirubin	21-30	albumin	Homo sapiens	13-20
34359658-6	2021	According to multivariate Cox regression analyses, albumin-bilirubin (ALBI) grade at the initiation of regorafenib therapy is an independent predictor of disease control, PFS, and OS.	Bilirubin	59-68	albumin	Homo sapiens	51-58
34336890-7	2021	BRD4 expression was positively correlated with the severity of liver fibrosis, and also correlated with the serum levels of aspartate aminotransferase and total bilirubin.	Bilirubin	161-170	bromodomain containing 4	Homo sapiens	0-4
34217369-5	2021	RESULTS: The administration of melittin was found to prevent the antitubercular drug-induced alterations in the diagnostic markers; reduced glutathione (GSH), direct bilirubin (DB), total bilirubin (TB), aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and total serum protein (TSP).	Bilirubin	166-175	melittin	Apis mellifera	31-39
34359970-3	2021	Labile heme is scavenged by hemopexin (Hx) and processed by heme oxygenase-1 (HO-1, Hmox1), resulting in its removal and the generation of biliverdin/bilirubin, carbon monoxide (CO) and iron.	Bilirubin	150-159	hemopexin	Mus musculus	28-37
34359970-3	2021	Labile heme is scavenged by hemopexin (Hx) and processed by heme oxygenase-1 (HO-1, Hmox1), resulting in its removal and the generation of biliverdin/bilirubin, carbon monoxide (CO) and iron.	Bilirubin	150-159	heme oxygenase 1	Mus musculus	60-76
34359970-3	2021	Labile heme is scavenged by hemopexin (Hx) and processed by heme oxygenase-1 (HO-1, Hmox1), resulting in its removal and the generation of biliverdin/bilirubin, carbon monoxide (CO) and iron.	Bilirubin	150-159	heme oxygenase 1	Mus musculus	78-82
34359970-3	2021	Labile heme is scavenged by hemopexin (Hx) and processed by heme oxygenase-1 (HO-1, Hmox1), resulting in its removal and the generation of biliverdin/bilirubin, carbon monoxide (CO) and iron.	Bilirubin	150-159	heme oxygenase 1	Mus musculus	84-89
34217369-5	2021	RESULTS: The administration of melittin was found to prevent the antitubercular drug-induced alterations in the diagnostic markers; reduced glutathione (GSH), direct bilirubin (DB), total bilirubin (TB), aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and total serum protein (TSP).	Bilirubin	188-197	melittin	Apis mellifera	31-39
34217369-5	2021	RESULTS: The administration of melittin was found to prevent the antitubercular drug-induced alterations in the diagnostic markers; reduced glutathione (GSH), direct bilirubin (DB), total bilirubin (TB), aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and total serum protein (TSP).	Bilirubin	199-201	melittin	Apis mellifera	31-39
34222023-8	2021	Our findings not only demonstrate that bilirubin is an unfavorable for patients with BRAF-mutant melanoma who received vemurafenib treatment, but also uncover the underlying mechanism by which bilirubin restrains the anticancer effect of vemurafenib on BRAF-mutant melanoma cells.	Bilirubin	193-202	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	253-257
34222023-0	2021	Bilirubin Restrains the Anticancer Effect of Vemurafenib on BRAF-Mutant Melanoma Cells Through ERK-MNK1 Signaling.	Bilirubin	0-9	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	60-64
34276670-2	2021	Gamma-glutamyl transpeptidase (GGT) and total bilirubin (TBIL) have different effects on inflammation: GGT has pro-inflammatory effects, on the contrary, TBIL has anti-inflammatory effects.	Bilirubin	46-55	inactive glutathione hydrolase 2	Homo sapiens	103-106
34276670-2	2021	Gamma-glutamyl transpeptidase (GGT) and total bilirubin (TBIL) have different effects on inflammation: GGT has pro-inflammatory effects, on the contrary, TBIL has anti-inflammatory effects.	Bilirubin	57-61	inactive glutathione hydrolase 2	Homo sapiens	103-106
34276670-2	2021	Gamma-glutamyl transpeptidase (GGT) and total bilirubin (TBIL) have different effects on inflammation: GGT has pro-inflammatory effects, on the contrary, TBIL has anti-inflammatory effects.	Bilirubin	154-158	inactive glutathione hydrolase 2	Homo sapiens	0-29
34276670-11	2021	TBIL was inversely proportional to CRP (rs=-0.328) and TNF(rs=-0.360), and positively proportional to C3 (rs=0.174) and C4 (rs=0.172).	Bilirubin	0-4	C-reactive protein	Homo sapiens	35-38
34276670-11	2021	TBIL was inversely proportional to CRP (rs=-0.328) and TNF(rs=-0.360), and positively proportional to C3 (rs=0.174) and C4 (rs=0.172).	Bilirubin	0-4	tumor necrosis factor	Homo sapiens	55-58
34222023-0	2021	Bilirubin Restrains the Anticancer Effect of Vemurafenib on BRAF-Mutant Melanoma Cells Through ERK-MNK1 Signaling.	Bilirubin	0-9	mitogen-activated protein kinase 1	Homo sapiens	95-98
34306369-5	2021	The relationships between the HCV-RNA, HCV Ag, HCV Ab, albumin (ALB), total bilirubin (TBIL), aminotransferase (ALT), and aspartate aminotransferase (AST) levels and the hepcidin levels was analyzed.	Bilirubin	76-85	hepcidin antimicrobial peptide	Homo sapiens	170-178
34222023-0	2021	Bilirubin Restrains the Anticancer Effect of Vemurafenib on BRAF-Mutant Melanoma Cells Through ERK-MNK1 Signaling.	Bilirubin	0-9	MAPK interacting serine/threonine kinase 1	Homo sapiens	99-103
34222023-4	2021	Here, we show that blood bilirubin in patients with BRAF-mutant melanoma treated with vemurafenib is negatively correlated with clinical outcomes.	Bilirubin	25-34	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	52-56
34222023-5	2021	In vitro and animal experiments show that bilirubin can abrogate vemurafenib-induced growth suppression of BRAF-mutant melanoma cells.	Bilirubin	42-51	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	107-111
34222023-7	2021	Mechanically, the activation of ERK-MNK1 axis is required for bilirubin-induced reversal effects post vemurafenib treatment.	Bilirubin	62-71	mitogen-activated protein kinase 1	Homo sapiens	32-35
34222023-7	2021	Mechanically, the activation of ERK-MNK1 axis is required for bilirubin-induced reversal effects post vemurafenib treatment.	Bilirubin	62-71	MAPK interacting serine/threonine kinase 1	Homo sapiens	36-40
34139706-5	2022	The primary outcome of the study was total bilirubin reduction during MARS and during SPAD therapies.	Bilirubin	43-52	methionyl-tRNA synthetase 1	Homo sapiens	70-74
34169080-8	2021	Results: The baseline data suggested that patients in low serum bilirubin group had significantly higher levels of systolic blood pressure, proteinuria, serum creatinine and crescent formation ratio and lower levels of serum albumin and hemoglobin.	Bilirubin	64-73	albumin	Homo sapiens	219-232
34117260-0	2021	A UGT1A1 variant is associated with serum total bilirubin levels, which are causal for hypertension in African-ancestry individuals.	Bilirubin	48-57	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	2-8
34117260-9	2021	Our finding confirms that UGT1A1 influences bilirubin levels.	Bilirubin	44-53	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	26-32
34126939-9	2021	All three groups presented similar biochemical responses at week 4, patients treated with TAF showed a priority in total bilirubin reduction, albumin and cholesterol maintenance.	Bilirubin	121-130	TATA-box binding protein associated factor 8	Homo sapiens	90-93
34127764-1	2021	Human serum albumin (HSA) constitutes the primary transporter of fatty acids, bilirubin, and other plasma compounds.	Bilirubin	78-87	albumin	Homo sapiens	6-19
34220324-2	2021	We conducted this study to explore the relationship between serum bilirubin and renal outcome of patients with IgAN.	Bilirubin	66-75	IGAN1	Homo sapiens	111-115
34220324-3	2021	Methods: A total of 1492 biopsy proven IgAN patients were recruited and divided into two groups according to their median serum bilirubin concentration: the low bilirubin group (serum bilirubin<=9.7umol/L, n=753) and high bilirubin group (serum bilirubin>9.7umol/L, n=739).	Bilirubin	128-137	IGAN1	Homo sapiens	39-43
34220324-7	2021	Kaplan-Meier survival analysis was applied to explore the role of serum bilirubin in the progression of IgAN.	Bilirubin	72-81	IGAN1	Homo sapiens	104-108
34220324-8	2021	Three clinicopathological models of multivariate Cox regression analysis were established to evaluate the association of serum bilirubin and renal prognosis of IgAN.	Bilirubin	127-136	IGAN1	Homo sapiens	160-164
34220324-13	2021	The results of three models (including demographics, pathological, clinical indicators and serum bilirubin) demonstrated that a lower basic serum bilirubin level was significantly associated with a higher risk of reaching combined endpoints in IgAN patients both in unmatched and matched cohort.	Bilirubin	97-106	IGAN1	Homo sapiens	244-248
34220324-13	2021	The results of three models (including demographics, pathological, clinical indicators and serum bilirubin) demonstrated that a lower basic serum bilirubin level was significantly associated with a higher risk of reaching combined endpoints in IgAN patients both in unmatched and matched cohort.	Bilirubin	146-155	IGAN1	Homo sapiens	244-248
34220324-14	2021	Conclusion: Serum bilirubin level may be negatively associated with the progression of IgAN.	Bilirubin	18-27	IGAN1	Homo sapiens	87-91
34074250-0	2021	UGT1A1 mutation association with increased bilirubin levels and severity of unconjugated hyperbilirubinemia in ABO incompatible newborns of China.	Bilirubin	43-52	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
34074250-2	2021	Uridine diphosphate glucuronosyltransferase isoenzyme (UGT1A1) glucuronidates bilirubin and converts the toxic form of bilirubin to its nontoxic form.	Bilirubin	78-87	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	55-61
34074250-2	2021	Uridine diphosphate glucuronosyltransferase isoenzyme (UGT1A1) glucuronidates bilirubin and converts the toxic form of bilirubin to its nontoxic form.	Bilirubin	119-128	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	55-61
34074250-6	2021	UGT1A1 c.211 G > A mutation (UGT1A1*6, p.Arg71Gly, rs4148323) was significantly associated with the increased bilirubin level in ABO HDNs, after adjusted by age, sex and feeding method (P = 0.019 for TBIL, P = 0.02 for IBIL).	Bilirubin	110-119	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
34074250-6	2021	UGT1A1 c.211 G > A mutation (UGT1A1*6, p.Arg71Gly, rs4148323) was significantly associated with the increased bilirubin level in ABO HDNs, after adjusted by age, sex and feeding method (P = 0.019 for TBIL, P = 0.02 for IBIL).	Bilirubin	110-119	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	29-35
34074250-6	2021	UGT1A1 c.211 G > A mutation (UGT1A1*6, p.Arg71Gly, rs4148323) was significantly associated with the increased bilirubin level in ABO HDNs, after adjusted by age, sex and feeding method (P = 0.019 for TBIL, P = 0.02 for IBIL).	Bilirubin	110-119	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	129-132
34134005-0	2021	Albumin-bilirubin score as a useful predictor of energy malnutrition in patients with hepatocellular carcinoma.	Bilirubin	8-17	albumin	Homo sapiens	0-7
34295984-10	2021	Regarding markers of hepatic function, the albumin-bilirubin score decreased significantly during one year of therapy due to significantly elevated serum albumin and decreased total bilirubin levels.	Bilirubin	51-60	albumin	Homo sapiens	148-161
34268391-8	2021	Results: The Cox and DL clinical models were developed by adopting 7 independent prognostic factors (total bilirubin, prothrombin time, tumor size, tumor number, lymph node metastasis, and vascular invasion) and 22 clinical factors, respectively.	Bilirubin	107-116	cytochrome c oxidase subunit 8A	Homo sapiens	13-16
34093187-6	2021	Mechanistically, bilirubin prevented the infiltration of inflammatory cells, and decreased the levels of myeloperoxidase and pro-inflammatory cytokines in the serum and colon.	Bilirubin	17-26	myeloperoxidase	Mus musculus	105-120
34093191-9	2021	Results: In ATV-treated patients, hyperbilirubinemia (total bilirubin >1.2 mg/dl) had the main incidence (61.11%), and moderate and severe hyperbilirubinemia (total bilirubin >1.9 mg/dl) were statistically associated with UGT1A1*28 in recessive and codominant inheritance models (OR = 16.33, p = 0.028 and OR = 10.82, p = 0.036, respectively).	Bilirubin	165-174	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	222-228
34080071-6	2021	While low baseline albumin and high bilirubin values were associated with high IL6, liver cirrhosis, alcoholic liver disease, and portal vein infiltration were associated with high IL8.	Bilirubin	36-45	interleukin 6	Homo sapiens	79-82
34609801-3	2021	It happens as a result of an error in UGT1A1 enzyme which can cause high unconjugated bilirubin levels.	Bilirubin	86-95	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	38-44
34067839-0	2021	Identification of Binding Regions of Bilirubin in the Ligand-Binding Pocket of the Peroxisome Proliferator-Activated Receptor-A (PPARalpha).	Bilirubin	37-46	peroxisome proliferator activated receptor alpha	Homo sapiens	83-127
34067839-0	2021	Identification of Binding Regions of Bilirubin in the Ligand-Binding Pocket of the Peroxisome Proliferator-Activated Receptor-A (PPARalpha).	Bilirubin	37-46	peroxisome proliferator activated receptor alpha	Homo sapiens	129-138
34067839-1	2021	Recent work has shown that bilirubin has a hormonal function by binding to the peroxisome proliferator-activated receptor-alpha (PPARalpha), a nuclear receptor that drives the transcription of genes to control adiposity.	Bilirubin	27-36	peroxisome proliferator activated receptor alpha	Homo sapiens	79-127
34067839-1	2021	Recent work has shown that bilirubin has a hormonal function by binding to the peroxisome proliferator-activated receptor-alpha (PPARalpha), a nuclear receptor that drives the transcription of genes to control adiposity.	Bilirubin	27-36	peroxisome proliferator activated receptor alpha	Homo sapiens	129-138
34067839-2	2021	Our previous in silico work predicted three potential amino acids that bilirubin may interact with by hydrogen bonding in the PPARalpha ligand-binding domain (LBD), which could be responsible for the ligand-induced function.	Bilirubin	71-80	peroxisome proliferator activated receptor alpha	Homo sapiens	126-135
34067839-3	2021	To further reveal the amino acids that bilirubin interacts with in the PPARalpha LBD, we harnessed bilirubin"s known fluorescent properties when bound to proteins such as albumin.	Bilirubin	39-48	peroxisome proliferator activated receptor alpha	Homo sapiens	71-80
34067839-3	2021	To further reveal the amino acids that bilirubin interacts with in the PPARalpha LBD, we harnessed bilirubin"s known fluorescent properties when bound to proteins such as albumin.	Bilirubin	99-108	peroxisome proliferator activated receptor alpha	Homo sapiens	71-80
34067839-8	2021	This is the first study to reveal the amino acids responsible for bilirubin binding in the ligand-binding pocket of PPARalpha.	Bilirubin	66-75	peroxisome proliferator activated receptor alpha	Homo sapiens	116-125
35512135-7	2022	Of nine polymorphisms previously associated with dolutegravir pharmacokinetics, the lowest P-value with AUCVAR was UGT1A1 rs887829 (P = 1.8 x 10-4), which was also associated with log10 bilirubin (P = 8.6 x 10-13).	Bilirubin	186-195	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	115-121
34141982-11	2021	We found that 13-HODE and 12,13-EpOME (elevated and decreased, respectively) in combination with elevated interleukin-1beta as independent predictors can effectively predict altered liver function as defined by elevated bilirubin levels.	Bilirubin	220-229	interleukin 1 beta	Homo sapiens	106-123
34272713-9	2021	Examples of adaptive nontoxic changes in liver function, which may elevate direct (conjugated) and/or indirect (unconjugated) bilirubin above baseline levels, include reversible inhibition of UGT1A1-mediated bilirubin metabolism and OATP1B1-, OATP1B3-, or MRP2-mediated transport.	Bilirubin	126-135	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	192-198
34272713-9	2021	Examples of adaptive nontoxic changes in liver function, which may elevate direct (conjugated) and/or indirect (unconjugated) bilirubin above baseline levels, include reversible inhibition of UGT1A1-mediated bilirubin metabolism and OATP1B1-, OATP1B3-, or MRP2-mediated transport.	Bilirubin	126-135	solute carrier organic anion transporter family member 1B1	Homo sapiens	233-240
34272713-9	2021	Examples of adaptive nontoxic changes in liver function, which may elevate direct (conjugated) and/or indirect (unconjugated) bilirubin above baseline levels, include reversible inhibition of UGT1A1-mediated bilirubin metabolism and OATP1B1-, OATP1B3-, or MRP2-mediated transport.	Bilirubin	126-135	solute carrier organic anion transporter family member 1B3	Homo sapiens	243-250
34272713-9	2021	Examples of adaptive nontoxic changes in liver function, which may elevate direct (conjugated) and/or indirect (unconjugated) bilirubin above baseline levels, include reversible inhibition of UGT1A1-mediated bilirubin metabolism and OATP1B1-, OATP1B3-, or MRP2-mediated transport.	Bilirubin	126-135	ATP binding cassette subfamily C member 2	Homo sapiens	256-260
34272713-9	2021	Examples of adaptive nontoxic changes in liver function, which may elevate direct (conjugated) and/or indirect (unconjugated) bilirubin above baseline levels, include reversible inhibition of UGT1A1-mediated bilirubin metabolism and OATP1B1-, OATP1B3-, or MRP2-mediated transport.	Bilirubin	208-217	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	192-198
35381939-0	2022	ASO Visual Abstract: Association Between Albumin-Bilirubin Grade and Myosteatosis and Its Prognostic Significance for Patients with Colorectal Cancer.	Bilirubin	49-58	albumin	Homo sapiens	41-48
35633504-9	2022	Furthermore, for modified albumin-bilirubin grade (mALBI)-1/2a/2b, mPFS was 9.4/8.5/5.3 months (P<0.001) and mOS was NE/17.8/13.4 months (P<0.001).	Bilirubin	34-43	Moloney sarcoma oncogene	Mus musculus	109-112
35610317-8	2022	(2) GDF15 was positively correlated with M2BPGi (r = 0.7728), total bilirubin (r = 0.6231), and PT-INR (r = 0.6332).	Bilirubin	68-77	growth differentiation factor 15	Homo sapiens	4-9
35625637-9	2022	MMP-9 was positively correlated with alanine aminotransferase (ALT) (r = 0.38; p = 0.004) and total bilirubin (r = 0.39; p = 0.004).	Bilirubin	100-109	matrix metallopeptidase 9	Homo sapiens	0-5
35552472-1	2022	Glecaprevir is a substrate for organic anion-transporting polypeptide (OATP) 1B1/1B3, which transports bilirubin.	Bilirubin	103-112	solute carrier organic anion transporter family member 1B1	Homo sapiens	31-84
35391541-5	2022	The primary objective is to demonstrate that GCSF decreases the proportion of subjects with a 3-month post-Kasai serum Total Bilirubin >= 34 umol/L by 20%, (for a = 0.05, b = 0.80, i.e., calculated sample size of 218 subjects).	Bilirubin	125-134	colony stimulating factor 3	Homo sapiens	45-49
35622307-12	2022	Also, ELOVL5 expression is negatively correlated with total bilirubin and direct bilirubin levels in the CAD group.	Bilirubin	60-69	ELOVL fatty acid elongase 5	Homo sapiens	6-12
35622307-12	2022	Also, ELOVL5 expression is negatively correlated with total bilirubin and direct bilirubin levels in the CAD group.	Bilirubin	81-90	ELOVL fatty acid elongase 5	Homo sapiens	6-12
35604090-0	2022	Bilirubin inhibits the anticancer activity of sorafenib by blocking MCL-1 degradation in hepatocellular carcinoma cells.	Bilirubin	0-9	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	68-73
35604090-10	2022	Mechanically, bilirubin inhibited sorafenib-induced activation of GSK-3beta and subsequent downstream MCL-1 degradation.	Bilirubin	14-23	glycogen synthase kinase 3 alpha	Homo sapiens	66-75
35604090-10	2022	Mechanically, bilirubin inhibited sorafenib-induced activation of GSK-3beta and subsequent downstream MCL-1 degradation.	Bilirubin	14-23	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	102-107
35501760-6	2022	To the combined of UGT1A1, total bilirubin levels in homozygous variant were higher significantly than heterozygous variant and wild type (P = 0.002, P = 0.003, respectively).	Bilirubin	33-42	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	19-25
35508528-7	2022	SCTR expression was also significantly lower (42 (24-63) vs 75 (39-107) fold, P = 0.015) among those who normalized their serum bilirubin after PE.	Bilirubin	128-137	secretin receptor	Homo sapiens	0-4
35417838-7	2022	Jaundice and the presence of bilirubin do not appear to cause harm to the function or health of the true vocal folds and may be related to the high concentration of elastin present in the true vocal folds.	Bilirubin	29-38	elastin	Homo sapiens	165-172
35484230-4	2022	This occurs via microbial beta-glucuronidase-mediated conversion of bilirubin conjugates.	Bilirubin	68-77	glucuronidase, beta	Mus musculus	26-44
35241486-0	2022	Inhibition of Human UGT1A1-Mediated Bilirubin Glucuronidation by the Popular Flavonoids Baicalein, Baicalin and Hyperoside is responsible for Herbs (Shuang-huang-lian) -Induced Jaundice.	Bilirubin	36-45	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	20-26
35241486-3	2022	The aim of this paper was to explore the mechanism of Shuang-huang-lian injections (SHL) and its major constituents-induced jaundice via inhibiting human UDP-glucuronosyltransferases1A1 (hUGT1A1)-mediated bilirubin glucuronidation.	Bilirubin	205-214	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	187-194
35241486-7	2022	Both inhibition kinetics assays and molecular docking simulations suggested that SHL, BAI, BA, and HYP significantly inhibited hUGT1A1-mediated bilirubin glucuronidation via a mixed-type inhibition.	Bilirubin	144-153	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	127-134
35241486-8	2022	Collectively, some naturally occurring flavonoids (BAI, BA and HYP) in SHL have been identified as the inhibitors against hUGT1A1-mediated bilirubin glucuronidation, which well-explains the bilirubin-related ADRs or malady triggered by SHL in clinical settings.	Bilirubin	139-148	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	122-129
35241486-8	2022	Collectively, some naturally occurring flavonoids (BAI, BA and HYP) in SHL have been identified as the inhibitors against hUGT1A1-mediated bilirubin glucuronidation, which well-explains the bilirubin-related ADRs or malady triggered by SHL in clinical settings.	Bilirubin	190-199	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	122-129
35241486-10	2022	As a commonly used herbal products rich in flavonoids, Shuang-huang-lian injections (SHL), easily lead to symptoms of liver injury (e.g., jaundice) owing to significant inhibition of hUGT1A1-mediated bilirubin glucuronidation by its flavonoid components (i.e., baicalein, baicalin, hyperoside).	Bilirubin	200-209	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	183-190
35149777-0	2022	UGT1A1 genetic variants are associated with increases in bilirubin levels in rheumatoid arthritis patients treated with sarilumab.	Bilirubin	57-66	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
35149777-5	2022	Variants in the UGT1A1 gene were strongly associated with maximum bilirubin elevations in sarilumab-treated patients (rs4148325; p = 2.88 x 10-41) but were not associated with aminotransferase elevations.	Bilirubin	66-75	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	16-22
35149777-7	2022	These findings suggest that most bilirubin increases during sarilumab treatment are related to genetic variation in UGT1A1 rather than underlying liver injury.	Bilirubin	33-42	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	116-122
35477852-4	2022	A polymorphism in the ABCC2 gene causes malfunctions in its ability to regulate the efflux of different organic anions, such as bilirubin, from hepatocytes to the canaliculi.	Bilirubin	128-137	ATP binding cassette subfamily C member 2	Homo sapiens	22-27
35573949-3	2022	This study aimed to investigate the role of IVIG in the prevention of exchange transfusion in infants with ABO HDN who presented with bilirubin levels at or above the level of exchange transfusion.	Bilirubin	134-143	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	107-110
35477852-5	2022	Multidrug resistance protein 2 (MRP2) encoded by the ABCC2 gene is one of the main regulators of the export of bilirubin to respective sites.	Bilirubin	111-120	ATP binding cassette subfamily C member 2	Homo sapiens	0-30
35477852-5	2022	Multidrug resistance protein 2 (MRP2) encoded by the ABCC2 gene is one of the main regulators of the export of bilirubin to respective sites.	Bilirubin	111-120	ATP binding cassette subfamily C member 2	Homo sapiens	32-36
35477852-5	2022	Multidrug resistance protein 2 (MRP2) encoded by the ABCC2 gene is one of the main regulators of the export of bilirubin to respective sites.	Bilirubin	111-120	ATP binding cassette subfamily C member 2	Homo sapiens	53-58
35477852-11	2022	These 41 variants had highly damaging effects on the MRP2 protein, which may lead to deficient transportation capacity, thereby affecting the efflux of bilirubin across the canalicular membrane.	Bilirubin	152-161	ATP binding cassette subfamily C member 2	Homo sapiens	53-57
35548345-0	2022	Bilirubin Improves Gap Junction to Alleviate Doxorubicin-Induced Cardiotoxicity by Regulating AMPK-Axl-SOCS3-Cx43 Axis.	Bilirubin	0-9	RAS p21 protein activator 1	Rattus norvegicus	19-22
35548345-0	2022	Bilirubin Improves Gap Junction to Alleviate Doxorubicin-Induced Cardiotoxicity by Regulating AMPK-Axl-SOCS3-Cx43 Axis.	Bilirubin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	94-98
35548345-0	2022	Bilirubin Improves Gap Junction to Alleviate Doxorubicin-Induced Cardiotoxicity by Regulating AMPK-Axl-SOCS3-Cx43 Axis.	Bilirubin	0-9	Axl receptor tyrosine kinase	Rattus norvegicus	99-102
35548345-0	2022	Bilirubin Improves Gap Junction to Alleviate Doxorubicin-Induced Cardiotoxicity by Regulating AMPK-Axl-SOCS3-Cx43 Axis.	Bilirubin	0-9	suppressor of cytokine signaling 3	Rattus norvegicus	103-108
35548345-0	2022	Bilirubin Improves Gap Junction to Alleviate Doxorubicin-Induced Cardiotoxicity by Regulating AMPK-Axl-SOCS3-Cx43 Axis.	Bilirubin	0-9	gap junction protein, alpha 1	Rattus norvegicus	109-113
35548345-6	2022	Consecutive intraperitoneal injection of bilirubin for 7 days significantly attenuated doxorubicin-induced arrhythmia, prolonged survival time and reduced the levels of aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase MB (CK-MB) and alpha-hydroxybutyrate dehydrogenase (alpha-HBDH) in mice.	Bilirubin	41-50	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	169-195
35548345-6	2022	Consecutive intraperitoneal injection of bilirubin for 7 days significantly attenuated doxorubicin-induced arrhythmia, prolonged survival time and reduced the levels of aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase MB (CK-MB) and alpha-hydroxybutyrate dehydrogenase (alpha-HBDH) in mice.	Bilirubin	41-50	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	197-200
35548345-7	2022	Bilirubin also markedly inhibited doxorubicin-induced phosphorylation of c-Jun N-terminal kinase (JNK) and connexin 43 (Cx43), and improved gap junction function in vitro and in vivo.	Bilirubin	0-9	mitogen-activated protein kinase 8	Rattus norvegicus	73-96
35548345-7	2022	Bilirubin also markedly inhibited doxorubicin-induced phosphorylation of c-Jun N-terminal kinase (JNK) and connexin 43 (Cx43), and improved gap junction function in vitro and in vivo.	Bilirubin	0-9	mitogen-activated protein kinase 8	Rattus norvegicus	98-101
35548345-7	2022	Bilirubin also markedly inhibited doxorubicin-induced phosphorylation of c-Jun N-terminal kinase (JNK) and connexin 43 (Cx43), and improved gap junction function in vitro and in vivo.	Bilirubin	0-9	gap junction protein, alpha 1	Rattus norvegicus	107-118
35548345-7	2022	Bilirubin also markedly inhibited doxorubicin-induced phosphorylation of c-Jun N-terminal kinase (JNK) and connexin 43 (Cx43), and improved gap junction function in vitro and in vivo.	Bilirubin	0-9	gap junction protein, alpha 1	Rattus norvegicus	120-124
35548345-7	2022	Bilirubin also markedly inhibited doxorubicin-induced phosphorylation of c-Jun N-terminal kinase (JNK) and connexin 43 (Cx43), and improved gap junction function in vitro and in vivo.	Bilirubin	0-9	RAS p21 protein activator 1	Rattus norvegicus	140-143
35548345-8	2022	In addition, bilirubin activated adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) and induced suppressor of cytokine signaling 3 (SOCS3) expression, which was abolished by Axl inhibition.	Bilirubin	13-22	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	33-90
35548345-8	2022	In addition, bilirubin activated adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) and induced suppressor of cytokine signaling 3 (SOCS3) expression, which was abolished by Axl inhibition.	Bilirubin	13-22	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	92-96
35548345-8	2022	In addition, bilirubin activated adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) and induced suppressor of cytokine signaling 3 (SOCS3) expression, which was abolished by Axl inhibition.	Bilirubin	13-22	suppressor of cytokine signaling 3	Rattus norvegicus	110-144
35461226-7	2022	Patients with high serum AFP levels had higher protein induced by vitamin K absence or antagonist-II (PIVKA-II), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alpha-l-fucosidase (AFU), gamma-glutamyl transpeptidase (gamma-GT), gamma-GT /ALT, direct bilirubin (DBIL), indirect bilirubin (IDBIL), fibrinogen, and D-dimer levels.	Bilirubin	269-278	alpha fetoprotein	Homo sapiens	25-28
35548345-8	2022	In addition, bilirubin activated adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) and induced suppressor of cytokine signaling 3 (SOCS3) expression, which was abolished by Axl inhibition.	Bilirubin	13-22	suppressor of cytokine signaling 3	Rattus norvegicus	146-151
35461226-7	2022	Patients with high serum AFP levels had higher protein induced by vitamin K absence or antagonist-II (PIVKA-II), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alpha-l-fucosidase (AFU), gamma-glutamyl transpeptidase (gamma-GT), gamma-GT /ALT, direct bilirubin (DBIL), indirect bilirubin (IDBIL), fibrinogen, and D-dimer levels.	Bilirubin	296-305	alpha fetoprotein	Homo sapiens	25-28
35548345-8	2022	In addition, bilirubin activated adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) and induced suppressor of cytokine signaling 3 (SOCS3) expression, which was abolished by Axl inhibition.	Bilirubin	13-22	Axl receptor tyrosine kinase	Rattus norvegicus	188-191
35548345-9	2022	Moreover, pretreatment with AMPK agonist or AMPK inhibitor could mimic or abolish the cardioprotective effect of bilirubin on H9C2 cells in vitro, respectively.	Bilirubin	113-122	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	28-32
35548345-9	2022	Moreover, pretreatment with AMPK agonist or AMPK inhibitor could mimic or abolish the cardioprotective effect of bilirubin on H9C2 cells in vitro, respectively.	Bilirubin	113-122	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	44-48
35548345-10	2022	Altogether, bilirubin upregulates gap junctions" function to protect against doxorubicin-induced cardiotoxicity by activating AMPK-Axl-SOCS3 signaling axis.	Bilirubin	12-21	RAS p21 protein activator 1	Rattus norvegicus	34-37
35548345-10	2022	Altogether, bilirubin upregulates gap junctions" function to protect against doxorubicin-induced cardiotoxicity by activating AMPK-Axl-SOCS3 signaling axis.	Bilirubin	12-21	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	126-130
35548345-10	2022	Altogether, bilirubin upregulates gap junctions" function to protect against doxorubicin-induced cardiotoxicity by activating AMPK-Axl-SOCS3 signaling axis.	Bilirubin	12-21	Axl receptor tyrosine kinase	Rattus norvegicus	131-134
35548345-10	2022	Altogether, bilirubin upregulates gap junctions" function to protect against doxorubicin-induced cardiotoxicity by activating AMPK-Axl-SOCS3 signaling axis.	Bilirubin	12-21	suppressor of cytokine signaling 3	Rattus norvegicus	135-140
35565221-4	2022	We compared the prognostic predictive utility of the prognostic nutritional index, neutrophil/lymphocyte and platelet/lymphocyte ratios, controlling nutritional status score, GPS, and neo-GPS, which uses albumin-bilirubin grade (ALBI) instead of albumin.	Bilirubin	212-221	albumin	Homo sapiens	204-211
35480872-0	2022	Biliverdin/Bilirubin Redox Pair Protects Lens Epithelial Cells against Oxidative Stress in Age-Related Cataract by Regulating NF-kappaB/iNOS and Nrf2/HO-1 Pathways.	Bilirubin	11-20	nuclear factor kappa B subunit 1	Homo sapiens	126-135
35444014-1	2022	OBJECTIVE: Multidrug resistance protein 2 (MRP2) is a bottleneck in bilirubin excretion.	Bilirubin	68-77	ATP binding cassette subfamily C member 2	Homo sapiens	11-41
35444014-1	2022	OBJECTIVE: Multidrug resistance protein 2 (MRP2) is a bottleneck in bilirubin excretion.	Bilirubin	68-77	ATP binding cassette subfamily C member 2	Homo sapiens	43-47
35444014-15	2022	In both Fxr -/- and LPS-treated mice, ectopic FOXA2 expression restored apical MRP2 expression and normalised serum bilirubin levels.	Bilirubin	116-125	nuclear receptor subfamily 1, group H, member 4	Mus musculus	8-11
35444014-15	2022	In both Fxr -/- and LPS-treated mice, ectopic FOXA2 expression restored apical MRP2 expression and normalised serum bilirubin levels.	Bilirubin	116-125	forkhead box A2	Mus musculus	46-51
35436954-2	2022	BACKGROUND: Several mutations of bilirubin uridine diphosphate-glucuronosyltransferase gene (UGT1A1) have been reported in patients with unconjugated hyperbilirubinemia.	Bilirubin	33-42	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	93-99
35529854-10	2022	The serum MMP-3 concentration was significantly elevated in patients with higher bilirubin concentration (107.6 +- 85.8 vs 61.6 +- 46.1 ng/mL, p < 0.001) and was correlated with the level of antimitochondrial antibodies specific for PBC.	Bilirubin	81-90	matrix metallopeptidase 3	Homo sapiens	10-15
35565192-4	2022	(3) Results: cfDNA, specifically alpha-fetoprotein (AFP) expression in captured cfDNA, demonstrated the highest accuracy for diagnosing malignancies among the serum/plasma biomarkers used in this study, including AFP, aspartate aminotransferase, alanine aminotransferase, albumin, alkaline phosphatase, and bilirubin.	Bilirubin	307-316	alpha fetoprotein	Homo sapiens	33-50
35565192-4	2022	(3) Results: cfDNA, specifically alpha-fetoprotein (AFP) expression in captured cfDNA, demonstrated the highest accuracy for diagnosing malignancies among the serum/plasma biomarkers used in this study, including AFP, aspartate aminotransferase, alanine aminotransferase, albumin, alkaline phosphatase, and bilirubin.	Bilirubin	307-316	alpha fetoprotein	Homo sapiens	52-55
35565192-4	2022	(3) Results: cfDNA, specifically alpha-fetoprotein (AFP) expression in captured cfDNA, demonstrated the highest accuracy for diagnosing malignancies among the serum/plasma biomarkers used in this study, including AFP, aspartate aminotransferase, alanine aminotransferase, albumin, alkaline phosphatase, and bilirubin.	Bilirubin	307-316	alpha fetoprotein	Homo sapiens	213-216
35480872-0	2022	Biliverdin/Bilirubin Redox Pair Protects Lens Epithelial Cells against Oxidative Stress in Age-Related Cataract by Regulating NF-kappaB/iNOS and Nrf2/HO-1 Pathways.	Bilirubin	11-20	nitric oxide synthase 2	Homo sapiens	136-140
35480872-0	2022	Biliverdin/Bilirubin Redox Pair Protects Lens Epithelial Cells against Oxidative Stress in Age-Related Cataract by Regulating NF-kappaB/iNOS and Nrf2/HO-1 Pathways.	Bilirubin	11-20	NFE2 like bZIP transcription factor 2	Homo sapiens	145-149
35480872-0	2022	Biliverdin/Bilirubin Redox Pair Protects Lens Epithelial Cells against Oxidative Stress in Age-Related Cataract by Regulating NF-kappaB/iNOS and Nrf2/HO-1 Pathways.	Bilirubin	11-20	heme oxygenase 1	Homo sapiens	150-154
35419301-3	2022	The upregulation of HO-1 under pathological conditions associated with cellular stress represents an important cytoprotective defense mechanism by virtue of the anti-oxidant properties of the bilirubin and the anti-inflammatory effect of the CO produced.	Bilirubin	192-201	heme oxygenase 1	Homo sapiens	20-24
35074787-0	2022	Bilirubin Reduces the Uptake of Estrogen Precursors and the Followed Synthesis of Estradiol in Human Placental Syncytiotrophoblasts via Inhibition and Down-regulation of OAT4.	Bilirubin	0-9	solute carrier family 22 member 9	Homo sapiens	170-174
35074787-6	2022	In addition, immunostaining and Western Blot results revealed a distinct down-regulation of hOAT4 protein expression in PHTCs pretreated with 2.5 muM bilirubin.	Bilirubin	150-159	solute carrier family 22 member 9	Homo sapiens	92-97
35074787-7	2022	In conclusion, this study demonstrated that bilirubin reduced the uptake of estrogen precursors and the followed synthesis of estradiol in human placenta via inhibition and down-regulation of OAT4.	Bilirubin	44-53	solute carrier family 22 member 9	Homo sapiens	192-196
35074787-8	2022	Significance Statement Fetal metabolites, especially bilirubin, was first identified with significant inhibitory effects on the hOAT4-mediated uptake of estrogen precursor DHEAS in hOAT4-CHO, JEG-3 and PHTCs.	Bilirubin	53-62	solute carrier family 22 member 9	Homo sapiens	128-133
35074787-8	2022	Significance Statement Fetal metabolites, especially bilirubin, was first identified with significant inhibitory effects on the hOAT4-mediated uptake of estrogen precursor DHEAS in hOAT4-CHO, JEG-3 and PHTCs.	Bilirubin	53-62	solute carrier family 22 member 9	Homo sapiens	181-186
35074787-9	2022	Bilirubin concentration-dependently suppressed the estradiol synthesis and secretion in PHTCs treated with DHEAS, which was synchronized with the decline of hOAT4 protein expression.	Bilirubin	0-9	solute carrier family 22 member 9	Homo sapiens	157-162
35119581-1	2022	BACKGROUND: Albumin-bilirubin (ALBI) grade is used to evaluate the outcome of patients with hepatocellular carcinoma (HCC) which is often associated with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection.	Bilirubin	20-29	albumin	Homo sapiens	12-19
35156712-3	2022	Therefore, elevated LDL receptor expression potentially leads to reduced circulating cholesterol levels in female Gunn rats providing an explanation for the hypocholesterolaemia observed in humans with elevated bilirubin levels.	Bilirubin	211-220	low density lipoprotein receptor	Rattus norvegicus	20-32
35432184-11	2021	TBil and DBil were negatively correlated with total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), fasting insulin (FINS), hsCRP and HOMA-IR, even after adjusted for age, gender and BMI (all P <0.01).	Bilirubin	0-4	insulin	Homo sapiens	123-130
35410441-0	2022	Correction to: The mildly decreased preoperative bilirubin level is a risk factor for periprosthetic joint infection after total hip and knee arthroplasty.	Bilirubin	49-58	hedgehog interacting protein	Homo sapiens	129-132
35517415-5	2022	Biliverdin reductase B (BLVRB) is a non-redundant NAD(P)H-dependent biliverdin reductase that regulates cellular redox status by reducing biliverdin to bilirubin.	Bilirubin	152-161	biliverdin reductase B	Homo sapiens	0-22
35517415-5	2022	Biliverdin reductase B (BLVRB) is a non-redundant NAD(P)H-dependent biliverdin reductase that regulates cellular redox status by reducing biliverdin to bilirubin.	Bilirubin	152-161	biliverdin reductase B	Homo sapiens	24-29
35473828-12	2022	Bilirubin, ALP and GGT peak at 3 to 5 days and, return to baseline in the minority of patients at median follow-up of 16 days.	Bilirubin	0-9	alkaline phosphatase, placental	Homo sapiens	11-14
35342055-2	2022	This study was aimed to evaluate the effect of serum albumin level on the transcutaneous bilirubin (TcB) measurements in term neonates with unconjugated hyperbilirubinemia.	Bilirubin	89-98	albumin	Homo sapiens	47-60
35341795-3	2022	We previously showed that mouse hepatic Cyp2a5 is induced during reductive ER stress caused by the intramolecular disulfide form of dithiothreitol, trans-4,5-dihydroxy-1,2-dithiane (DTTox), and that overexpression of Cyp2a5 provides partial protection against apoptosis due to bilirubin (BR), a compound known to cause ER stress.	Bilirubin	277-286	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	40-46
35453551-8	2022	Presence of anti-KLHL12 was also associated with a higher concentration of bilirubin and correlated with fibrosis (p < 0.05).	Bilirubin	75-84	kelch like family member 12	Homo sapiens	17-23
35401514-10	2022	VISTA-/- mice also have a significant survival deficit, higher levels of soluble indicators of liver injury (i.e., ALT, AST, bilirubin), and increased circulating proinflammatory cytokines (i.e., IL-6, IL-10, TNFalpha, IL-17F, IL-23, and MCP-1) following septic challenge.	Bilirubin	125-134	V-set immunoregulatory receptor	Mus musculus	0-5
35341795-3	2022	We previously showed that mouse hepatic Cyp2a5 is induced during reductive ER stress caused by the intramolecular disulfide form of dithiothreitol, trans-4,5-dihydroxy-1,2-dithiane (DTTox), and that overexpression of Cyp2a5 provides partial protection against apoptosis due to bilirubin (BR), a compound known to cause ER stress.	Bilirubin	277-286	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	217-223
35341795-3	2022	We previously showed that mouse hepatic Cyp2a5 is induced during reductive ER stress caused by the intramolecular disulfide form of dithiothreitol, trans-4,5-dihydroxy-1,2-dithiane (DTTox), and that overexpression of Cyp2a5 provides partial protection against apoptosis due to bilirubin (BR), a compound known to cause ER stress.	Bilirubin	288-290	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	40-46
35341795-3	2022	We previously showed that mouse hepatic Cyp2a5 is induced during reductive ER stress caused by the intramolecular disulfide form of dithiothreitol, trans-4,5-dihydroxy-1,2-dithiane (DTTox), and that overexpression of Cyp2a5 provides partial protection against apoptosis due to bilirubin (BR), a compound known to cause ER stress.	Bilirubin	288-290	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	217-223
35327498-5	2022	Serum bilirubin levels are positively correlated with the levels of the antioxidative enzymes as superoxide dismutase, catalase, and glutathione peroxidase, while it is inversely correlated with C-reactive protein, TNF-alpha, interleukin (IL)-2, IL-6, and IL-10 release in diabetic kidney disease.	Bilirubin	6-15	interleukin 6	Homo sapiens	246-250
35388287-9	2022	Analysis of regulatory mechanisms indicated that activation of the hepatic constitutive androstane receptor (CAR)-Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway by accumulating bilirubin may be responsible for changes in BA metabolomics in TR rats.	Bilirubin	189-198	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	75-107
35388287-9	2022	Analysis of regulatory mechanisms indicated that activation of the hepatic constitutive androstane receptor (CAR)-Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway by accumulating bilirubin may be responsible for changes in BA metabolomics in TR rats.	Bilirubin	189-198	NFE2 like bZIP transcription factor 2	Rattus norvegicus	159-163
35327498-5	2022	Serum bilirubin levels are positively correlated with the levels of the antioxidative enzymes as superoxide dismutase, catalase, and glutathione peroxidase, while it is inversely correlated with C-reactive protein, TNF-alpha, interleukin (IL)-2, IL-6, and IL-10 release in diabetic kidney disease.	Bilirubin	6-15	catalase	Homo sapiens	119-127
35327498-5	2022	Serum bilirubin levels are positively correlated with the levels of the antioxidative enzymes as superoxide dismutase, catalase, and glutathione peroxidase, while it is inversely correlated with C-reactive protein, TNF-alpha, interleukin (IL)-2, IL-6, and IL-10 release in diabetic kidney disease.	Bilirubin	6-15	interleukin 10	Homo sapiens	256-261
35327498-5	2022	Serum bilirubin levels are positively correlated with the levels of the antioxidative enzymes as superoxide dismutase, catalase, and glutathione peroxidase, while it is inversely correlated with C-reactive protein, TNF-alpha, interleukin (IL)-2, IL-6, and IL-10 release in diabetic kidney disease.	Bilirubin	6-15	C-reactive protein	Homo sapiens	195-213
35327498-5	2022	Serum bilirubin levels are positively correlated with the levels of the antioxidative enzymes as superoxide dismutase, catalase, and glutathione peroxidase, while it is inversely correlated with C-reactive protein, TNF-alpha, interleukin (IL)-2, IL-6, and IL-10 release in diabetic kidney disease.	Bilirubin	6-15	tumor necrosis factor	Homo sapiens	215-224
35327498-6	2022	Bilirubin downregulates NADPH oxidase, reduces the induction of pro-fibrotic factor HIF-1alpha expression, cleaved caspase-3, and cleaved PARP induction showing lower DNA fragmentation.	Bilirubin	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	84-94
35327498-5	2022	Serum bilirubin levels are positively correlated with the levels of the antioxidative enzymes as superoxide dismutase, catalase, and glutathione peroxidase, while it is inversely correlated with C-reactive protein, TNF-alpha, interleukin (IL)-2, IL-6, and IL-10 release in diabetic kidney disease.	Bilirubin	6-15	interleukin 2	Homo sapiens	226-244
35327498-6	2022	Bilirubin downregulates NADPH oxidase, reduces the induction of pro-fibrotic factor HIF-1alpha expression, cleaved caspase-3, and cleaved PARP induction showing lower DNA fragmentation.	Bilirubin	0-9	caspase 3	Homo sapiens	115-124
35327498-6	2022	Bilirubin downregulates NADPH oxidase, reduces the induction of pro-fibrotic factor HIF-1alpha expression, cleaved caspase-3, and cleaved PARP induction showing lower DNA fragmentation.	Bilirubin	0-9	collagen type XI alpha 2 chain	Homo sapiens	138-142
35368991-6	2022	The high BAFF group presented with higher bilirubin compared with the normal BAFF and high IL-21 groups (159 vs. 26 vs. 89 mumol/L; p = 0.001; Mann-Whitney U test).	Bilirubin	42-51	TNF superfamily member 13b	Homo sapiens	9-13
35151648-7	2022	On day 7 of healing, bilirubin nanoparticles treatment significantly reduced TNF-alpha and increased IL-10 levels with increased VEGF and TGF-beta1 expressions.	Bilirubin	21-30	tumor necrosis factor	Homo sapiens	77-86
35151648-7	2022	On day 7 of healing, bilirubin nanoparticles treatment significantly reduced TNF-alpha and increased IL-10 levels with increased VEGF and TGF-beta1 expressions.	Bilirubin	21-30	interleukin 10	Homo sapiens	101-106
35151648-7	2022	On day 7 of healing, bilirubin nanoparticles treatment significantly reduced TNF-alpha and increased IL-10 levels with increased VEGF and TGF-beta1 expressions.	Bilirubin	21-30	vascular endothelial growth factor A	Homo sapiens	129-133
35151648-7	2022	On day 7 of healing, bilirubin nanoparticles treatment significantly reduced TNF-alpha and increased IL-10 levels with increased VEGF and TGF-beta1 expressions.	Bilirubin	21-30	transforming growth factor beta 1	Homo sapiens	138-147
35229125-1	2022	OBJECTIVES: To characterize the outcomes of ABO incompatible direct antiglobulin test (DAT) positive newborns and determine the predictive ability of a sixth-hour transcutaneous bilirubin (TcB for needing phototherapy <=24 hours of age.	Bilirubin	178-187	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	44-47
35225327-7	2022	AITD was causally associated with increased erythrocyte distribution width (P = 0.007) and decreased reticulocyte counts (P <= 0.02), whereas high-normal FT4 regulated by DIO1/DIO2 variants was causally associated with decreased bilirubin (-0.039 (-0.064,-0.013), P = 0.003).	Bilirubin	229-238	iodothyronine deiodinase 1	Homo sapiens	171-175
35328217-1	2022	BACKGROUND AND AIMS: The Albumin-Bilirubin (ALBI) grade is a good index for liver function evaluation and is also associated with the outcomes of hepatocellular carcinoma patients receiving TACE.	Bilirubin	33-42	ADAM metallopeptidase domain 17	Homo sapiens	190-194
35281459-10	2022	It might be useful to use NAR, NTBR, and NIBR as predictive markers for disease severity and employ ALB/BIL as alternative therapy or adjuvant medicines in glaucoma patients.	Bilirubin	104-107	albumin	Homo sapiens	100-103
35353187-8	2022	Single-factor linear regression analysis showed that TBIL and DBIL showed the R2 values were 0.221 and 0.220, and the R2 values of UIBC, FIB, and maximal lesion diameter were 0.157, 0.174, and 0.167, respectively, and those of the remaining indicators were <0.1.	Bilirubin	53-57	fibrinogen beta chain	Homo sapiens	137-140
35281042-2	2022	Heme oxygenase-1 (HO-1) is an essential stress-response enzyme highly expressed in the lungs, and catabolizes heme into ferrous iron, carbon monoxide (CO), and biliverdin (BV)/bilirubin (BR), especially in pathological conditions which cause oxidative stress and inflammation.	Bilirubin	176-185	heme oxygenase 1	Homo sapiens	18-22
35281042-2	2022	Heme oxygenase-1 (HO-1) is an essential stress-response enzyme highly expressed in the lungs, and catabolizes heme into ferrous iron, carbon monoxide (CO), and biliverdin (BV)/bilirubin (BR), especially in pathological conditions which cause oxidative stress and inflammation.	Bilirubin	187-189	heme oxygenase 1	Homo sapiens	18-22
35192750-12	2022	There was no significant difference in the concentration of ALT, AST, cholesterol or LDL between different genotypes.The number of TA-repeats of the UGT1A1 gene affects the increase of total bilirubin and its indirect fraction, including the cases of rare allelic variants (TA<=5, TA>=8), but not the activity of ALT and AST and the lipid profile.	Bilirubin	191-200	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	149-155
35192750-12	2022	There was no significant difference in the concentration of ALT, AST, cholesterol or LDL between different genotypes.The number of TA-repeats of the UGT1A1 gene affects the increase of total bilirubin and its indirect fraction, including the cases of rare allelic variants (TA<=5, TA>=8), but not the activity of ALT and AST and the lipid profile.	Bilirubin	191-200	solute carrier family 17 member 5	Homo sapiens	321-324
35204817-6	2022	Circulating miR-199a-5p and miR-144 were associated with hemolytic biomarkers such as LDH, indirect bilirubin, AST, GGT, iron, ferritin, RBC, hemoglobin, and NOm, in addition to association with impaired clinical profile of SLU.	Bilirubin	100-109	microRNA 144	Homo sapiens	28-35
35113969-0	2022	Longitudinal increase in albumin-bilirubin score is associated with non-malignancy-related mortality and quality of life in patients with liver cirrhosis.	Bilirubin	33-42	albumin	Homo sapiens	25-32
35150577-7	2022	Tbeta4 promoter methylation frequency was correlated with serum total bilirubin, prothrombin activity and model for end-stage liver disease score.	Bilirubin	70-79	trace amine associated receptor 6	Homo sapiens	0-6
35017453-2	2022	High levels of raltegravir and dolutegravir can potentially cause bilirubin toxicity as they compete for albumin binding and follow the same metabolic pathway through UGT1A1.	Bilirubin	66-75	albumin	Homo sapiens	105-112
35045794-11	2022	These findings indicated that 4-PBA could alleviate RFP-induced cholestatic liver injury and thereby decreased serum total bilirubin concentration via inhibiting ER stress and ubiquitination degradation of MRP2, which provides new insights into the mechanism of 4-PBA in the treatment of RFP-induced cholestasis and liver damage.	Bilirubin	123-132	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	206-210
35017453-2	2022	High levels of raltegravir and dolutegravir can potentially cause bilirubin toxicity as they compete for albumin binding and follow the same metabolic pathway through UGT1A1.	Bilirubin	66-75	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	167-173
35204062-3	2022	Exercise elevates heme oxygenase-1 (HO-1) and biliverdin reductase A (BVRA) expression as built-in protective mechanisms, which produce the most potent antioxidant, bilirubin.	Bilirubin	165-174	heme oxygenase 1	Homo sapiens	18-34
35387724-12	2022	Correlation analysis showed that there was a clear positive correlation between AT III and TBil in the dead patients of HBV liver failure group and the survival and death patients of non-HBV liver failure group (r values were 0.069, 0.341, 0.064, and P values were 0.723, 1.196 and 0.761, respectively); there was a significant inverse correlation between AT III and TBil in the HBV liver failure group (r = -0.105, P = 0.745).	Bilirubin	91-95	serpin family C member 1	Homo sapiens	356-362
35387724-12	2022	Correlation analysis showed that there was a clear positive correlation between AT III and TBil in the dead patients of HBV liver failure group and the survival and death patients of non-HBV liver failure group (r values were 0.069, 0.341, 0.064, and P values were 0.723, 1.196 and 0.761, respectively); there was a significant inverse correlation between AT III and TBil in the HBV liver failure group (r = -0.105, P = 0.745).	Bilirubin	367-371	serpin family C member 1	Homo sapiens	80-86
35158917-2	2022	We aimed to develop and validate a new prognostic model based on tumor burden score (TBS) and albumin-bilirubin (ALBI) grade for HCC.	Bilirubin	102-111	albumin	Homo sapiens	94-101
35136484-4	2022	We found that upregulation of PPARgamma decreased the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBIL), and liver pathological damage and improved the 5-day survival rate.	Bilirubin	132-141	peroxisome proliferator activated receptor gamma	Mus musculus	30-39
35136484-4	2022	We found that upregulation of PPARgamma decreased the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBIL), and liver pathological damage and improved the 5-day survival rate.	Bilirubin	143-147	peroxisome proliferator activated receptor gamma	Mus musculus	30-39
35146010-12	2022	Malnutrition and bilirubin mainly mediate the ApoB paradox.	Bilirubin	17-26	apolipoprotein B	Homo sapiens	46-50
35281975-6	2022	Results: Results showed that the processes of albumin-bound bilirubin transfer to the hepatocytes, hepatic uptake, and storage via ligandin, hepatic conjugation via uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1), conjugation into the bile via MRP2 represent the main action mechanism of clofibrate that turns it into the bilirubin conjugates and expels it from the bile.	Bilirubin	60-69	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	214-220
35281975-6	2022	Results: Results showed that the processes of albumin-bound bilirubin transfer to the hepatocytes, hepatic uptake, and storage via ligandin, hepatic conjugation via uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1), conjugation into the bile via MRP2 represent the main action mechanism of clofibrate that turns it into the bilirubin conjugates and expels it from the bile.	Bilirubin	60-69	ATP binding cassette subfamily C member 2	Homo sapiens	253-257
35204062-3	2022	Exercise elevates heme oxygenase-1 (HO-1) and biliverdin reductase A (BVRA) expression as built-in protective mechanisms, which produce the most potent antioxidant, bilirubin.	Bilirubin	165-174	heme oxygenase 1	Homo sapiens	36-40
35204062-3	2022	Exercise elevates heme oxygenase-1 (HO-1) and biliverdin reductase A (BVRA) expression as built-in protective mechanisms, which produce the most potent antioxidant, bilirubin.	Bilirubin	165-174	biliverdin reductase A	Homo sapiens	46-68
35204062-3	2022	Exercise elevates heme oxygenase-1 (HO-1) and biliverdin reductase A (BVRA) expression as built-in protective mechanisms, which produce the most potent antioxidant, bilirubin.	Bilirubin	165-174	biliverdin reductase A	Homo sapiens	70-74
35204062-5	2022	Moderately raising plasma bilirubin protects in two ways: (1) via its antioxidant capacity to reduce ROS and inflammation, and (2) its newly defined function as a hormone that activates the nuclear receptor transcription factor PPARalpha.	Bilirubin	26-35	peroxisome proliferator activated receptor alpha	Homo sapiens	228-237
35204062-7	2022	The main objective of this review is to describe the function of bilirubin as an antioxidant and metabolic hormone and how the HO-1-BVRA-bilirubin-PPARalpha axis influences inflammation, metabolic function and interacts with exercise to improve outcomes of weight management.	Bilirubin	137-146	heme oxygenase 1	Homo sapiens	127-131
35204062-7	2022	The main objective of this review is to describe the function of bilirubin as an antioxidant and metabolic hormone and how the HO-1-BVRA-bilirubin-PPARalpha axis influences inflammation, metabolic function and interacts with exercise to improve outcomes of weight management.	Bilirubin	137-146	biliverdin reductase A	Homo sapiens	132-136
35204062-7	2022	The main objective of this review is to describe the function of bilirubin as an antioxidant and metabolic hormone and how the HO-1-BVRA-bilirubin-PPARalpha axis influences inflammation, metabolic function and interacts with exercise to improve outcomes of weight management.	Bilirubin	137-146	peroxisome proliferator activated receptor alpha	Homo sapiens	147-156
35065585-5	2022	Radiotherapy and bilirubin can produce an effect similar to metformin via AMPK pathway.	Bilirubin	17-26	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	74-78
35466629-12	2022	A very strong and positive association of visfatin levels with levels of bilirubin and alkaline phosphatases was also observed (ALP) but it found no effect on aspartate transferases (AST).	Bilirubin	73-82	nicotinamide phosphoribosyltransferase	Homo sapiens	42-50
34980160-4	2022	We found that mildly elevated bilirubin significantly reduced the risk factors of atherosclerosis, such as plasma glucose, total cholesterol, and low-density lipoprotein cholesterol, and the formation of atherosclerotic plaques, liver total cholesterol, and cholesterol ester concentration in apolipoprotein E-deficient (ApoE-/-) mice fed a western-type (high fat) diet.	Bilirubin	30-39	apolipoprotein E	Mus musculus	321-325
34980160-5	2022	It was further found that bilirubin could promote the degradation of 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR), a rate-limiting enzyme for endogenous cholesterol synthesis.	Bilirubin	26-35	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	69-109
34980160-5	2022	It was further found that bilirubin could promote the degradation of 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR), a rate-limiting enzyme for endogenous cholesterol synthesis.	Bilirubin	26-35	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	111-116
35005433-2	2022	Herein, we are reporting the third case of novel association of HbQ India with HbS trait hemoglobinopathy in a 30-year-old young male presented with chief complaints of yellowish discoloration of sclera since 5 years with raised serum bilirubin levels along with pedigree analysis of the family.	Bilirubin	235-244	hemoglobin subunit theta 1	Homo sapiens	64-67
34967426-9	2022	We were determined that the vast majority of patients with perforated appendicitis were male; had more frequent chronic kidney disease and post-operative local complications; had increased leukocytes, neutrophils, blood urea nitrogen, creatinine, and total bilirubin; and had reduced albumin; and these differences were statistically significant (all values p<0.05).	Bilirubin	257-266	3-hydroxyanthranilate 3,4-dioxygenase	Homo sapiens	175-178
2764944-4	1989	The phosphorylated transferase 1-1 showed decreased affinity for bilirubin, suggesting that the phosphorylation affects the function of glutathione S-transferase in an isozyme-specific manner.	Bilirubin	65-74	hematopoietic prostaglandin D synthase	Rattus norvegicus	136-161
2585024-6	1989	Multiple regression analysis revealed several factors that were significantly associated with the increase in bilirubin when jointly considered (model P2 less than or equal to .001) including total IL-2 dosage, increase in creatinine, alkaline phosphatase, weight, and SGOT.	Bilirubin	110-119	interleukin 2	Homo sapiens	198-202
2585024-8	1989	A return to normal levels of bilirubin was noted within 5.6 days of stopping IL-2.	Bilirubin	29-38	interleukin 2	Homo sapiens	77-81
2585024-12	1989	These findings support the development of profound reversible cholestasis as the primary basis for the elevated bilirubin in patients undergoing IL-2 treatment and may have implications for understanding the jaundice observed in some patients postoperatively as well as that associated with sepsis and other inflammatory disorders.	Bilirubin	112-121	interleukin 2	Homo sapiens	145-149
2814818-6	1989	The production of both interleukins correlated negatively with serum total bilirubin level (IL-1 r = -0.478, p less than 0.05; IL-2: r = -0.482, p less than 0.05) and positively with high-density lipoprotein cholesterol in serum (IL-1: r = 0.505, p less than 0.01; IL-2: r = 0.494, p less than 0.05).	Bilirubin	75-84	interleukin 1 alpha	Homo sapiens	92-96
2510730-7	1989	Evidence from enzyme induction and the genetically deficient deficient Gunn rat suggested that bilirubin UDPGT may be responsible for the (+)-morphine-3-UDP-glucuronosyltransferase activity.	Bilirubin	95-104	UDP glucuronosyltransferase family 2 member B15	Rattus norvegicus	105-110
2510730-7	1989	Evidence from enzyme induction and the genetically deficient deficient Gunn rat suggested that bilirubin UDPGT may be responsible for the (+)-morphine-3-UDP-glucuronosyltransferase activity.	Bilirubin	95-104	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	153-180
2572517-0	1989	Somatostatin inhibits the effect of secretin on bile flow and on hepatic bilirubin transport in the rat.	Bilirubin	73-82	somatostatin	Rattus norvegicus	0-12
2572517-4	1989	Somatostatin 0.2 and 0.8 microgram/h/100 g body wt caused a dose related inhibition of the hepatic effects of secretin both on bile flow and on biliary output of bilirubin conjugates.	Bilirubin	162-171	somatostatin	Rattus norvegicus	0-12
2779527-0	1989	Ceftriaxone binding to human serum albumin: competition with bilirubin.	Bilirubin	61-70	albumin	Homo sapiens	29-42
2780821-0	1989	Quantum yields for laser photocyclization of bilirubin in the presence of human serum albumin.	Bilirubin	45-54	albumin	Homo sapiens	86-93
2780821-2	1989	The quantum yield for laser photocyclization of bilirubin to lumirubin in the presence of human serum albumin (phi LR) was measured at five monochromatic excitation wavelengths in the range 450-530 nm.	Bilirubin	48-57	albumin	Homo sapiens	102-109
2776759-0	1989	Novel inhibitors and substrates of bilirubin: UDP-glucuronosyltransferase.	Bilirubin	35-44	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	46-73
35307063-11	2022	RESULTS: With the increase of bilirubin dose, the contents of 24-hour urine TP, blood TBil, blood DBil and MDA content in kidney tissue were gradually increased, and the SOD activity and WT-1 expression in kidney tissue were gradually decreased.	Bilirubin	30-39	WT1 transcription factor	Rattus norvegicus	187-191
2513736-5	1989	Serum apolipoprotein-AI was negatively correlated to semiquantitative score of fibrosis (r = -0.50; p less than 0.001), independently of the scores of steatosis and alcoholic hepatitis (r = -0.44; p less than 0.001) and of the value of serum albumin, bilirubin, and prothrombin time (r = -0.22; p less than 0.001) and independently of the nutritional parameters (r = -0.29; p less than 0.009).	Bilirubin	251-260	apolipoprotein A1	Homo sapiens	6-23
2560869-1	1989	A decrease in total activity of ATPase and in specific activity of Na+,K+-ATPase as well as less rapid and distinct decrease in specific activity of acetylcholinesterase were observed in synaptosomal membrane after binding of bilirubin in vitro.	Bilirubin	226-235	dynein axonemal heavy chain 8	Homo sapiens	32-38
2560869-1	1989	A decrease in total activity of ATPase and in specific activity of Na+,K+-ATPase as well as less rapid and distinct decrease in specific activity of acetylcholinesterase were observed in synaptosomal membrane after binding of bilirubin in vitro.	Bilirubin	226-235	dynein axonemal heavy chain 8	Homo sapiens	74-80
2560869-3	1989	Blood serum albumin, added to the suspension of bilirubin-containing particles of synaptosomal membrane, affected significantly the alterations in activity of membrane-bound enzymes caused by the irradiation.	Bilirubin	48-57	albumin	Homo sapiens	12-19
2776331-9	1989	However, samples from adults with cholestasis were overestimated, particularly by the CAF method, but the BOR and B-C methods would be suitable for "stat" bilirubin analysis in these samples.	Bilirubin	155-164	cell division cycle associated 8	Homo sapiens	106-117
2776759-4	1989	Among all the acids tested, 7,7,7-triphenylheptanoic acid was the most powerful inhibitor of bilirubin:UDP-glucuronosyltransferase with a lower effect on 1-naphtol, androsterone and testosterone glucuronidation.	Bilirubin	93-102	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	103-130
2776759-6	1989	Twenty analogues were examined, and the results showed that their inhibitory potency on bilirubin:UDP-glucuronosyltransferase activity was a function of at least three structural features (a) the presence of a hydrophobic triphenyl moiety; (b) the length of the aliphatic chain and (c) the presence of a carboxylic group.	Bilirubin	88-97	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	98-125
2776759-9	1989	However, 7,7,7-triphenylheptanoic acid was actively glucuronidated by purified bilirubin:UDP-glucuronosyltransferase, in contrast to its analogues with decreasing alkyl chain length.	Bilirubin	79-88	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	89-116
2546527-3	1989	Cholesterol calculi from 13 patients (10.2%) were observed to be associated with gall-bladder bile profusely infected with at least one bacterial species that was shown to possess beta-glucuronidase activity, an enzyme that is thought to promote calcium bilirubinate precipitation in bile.	Bilirubin	246-266	glucuronidase beta	Homo sapiens	180-198
2814336-4	1989	The amount of unconjugated bilirubin was significantly higher (p less than 0.01) in bile containing bacteria producing beta-glucuronidase than in bile without such bacterial strains.	Bilirubin	27-36	glucuronidase beta	Homo sapiens	119-137
2759339-9	1989	The stimulatory effect of albumin is not caused by bound fatty acids, nor by the presence of modified forms of albumin such as testibumin or the albumin-bilirubin complex.	Bilirubin	153-162	albumin	Rattus norvegicus	26-33
2663608-6	1989	In 9 out of 11 patients with intrahepatic cholestasis who were treated with secretin, levels of serum bilirubin decreased linearly and other liver function tests returned to the normal range.	Bilirubin	102-111	secretin	Homo sapiens	76-84
2663608-7	1989	The mean values of T1/2 (number of days required for reduction by half) of serum bilirubin in 9 effective cases to secretin was 10.8 days.	Bilirubin	81-90	secretin	Homo sapiens	115-123
2768223-0	1989	Protection of glutathione S-transferase from bilirubin inhibition.	Bilirubin	45-54	hematopoietic prostaglandin D synthase	Rattus norvegicus	14-39
2768223-1	1989	Inhibition of the enzyme activity of glutathione S-transferase (GST) by a physiological concentration of bilirubin was studied using various substrates.	Bilirubin	105-114	hematopoietic prostaglandin D synthase	Rattus norvegicus	37-62
2768223-1	1989	Inhibition of the enzyme activity of glutathione S-transferase (GST) by a physiological concentration of bilirubin was studied using various substrates.	Bilirubin	105-114	hematopoietic prostaglandin D synthase	Rattus norvegicus	64-67
2768223-3	1989	In contrast, bilirubin inhibited each of the purified GST isozymes and no remarkable difference in bilirubin inhibition was observed with any of the substrates tested.	Bilirubin	13-22	hematopoietic prostaglandin D synthase	Rattus norvegicus	54-57
2768223-4	1989	From the chromatographic analysis of the cytosol incubated with [3H]bilirubin, it was found that a major part of the added bilirubin binds to subunit 1 (Ya) of GST isozyme, leaving not only the conjugation activity derived from 3-4 type GST but also the CHPx activity of subunit 2 (Yc) quantitatively intact.	Bilirubin	68-77	hematopoietic prostaglandin D synthase	Rattus norvegicus	160-163
2768223-4	1989	From the chromatographic analysis of the cytosol incubated with [3H]bilirubin, it was found that a major part of the added bilirubin binds to subunit 1 (Ya) of GST isozyme, leaving not only the conjugation activity derived from 3-4 type GST but also the CHPx activity of subunit 2 (Yc) quantitatively intact.	Bilirubin	123-132	hematopoietic prostaglandin D synthase	Rattus norvegicus	160-163
2768223-4	1989	From the chromatographic analysis of the cytosol incubated with [3H]bilirubin, it was found that a major part of the added bilirubin binds to subunit 1 (Ya) of GST isozyme, leaving not only the conjugation activity derived from 3-4 type GST but also the CHPx activity of subunit 2 (Yc) quantitatively intact.	Bilirubin	123-132	hematopoietic prostaglandin D synthase	Rattus norvegicus	237-240
2768223-5	1989	The bilirubin inhibition of both the conjugation activity of GST 3-4 and the CHPx activity of GST 2-2 was prevented almost completely by addition of a 3-fold molar excess of GST 1-1.	Bilirubin	4-13	glutathione S-transferase pi 1	Rattus norvegicus	61-68
2768223-5	1989	The bilirubin inhibition of both the conjugation activity of GST 3-4 and the CHPx activity of GST 2-2 was prevented almost completely by addition of a 3-fold molar excess of GST 1-1.	Bilirubin	4-13	glutathione S-transferase alpha 1	Rattus norvegicus	94-101
2768223-5	1989	The bilirubin inhibition of both the conjugation activity of GST 3-4 and the CHPx activity of GST 2-2 was prevented almost completely by addition of a 3-fold molar excess of GST 1-1.	Bilirubin	4-13	glutathione S-transferase alpha 2	Rattus norvegicus	174-181
2733697-1	1989	The hypothesis that treatment of Gunn rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) activates an alternative pathway of bilirubin disposal, involving an induced form of cytochrome P-450 [Proc.	Bilirubin	127-136	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	176-192
2615647-0	1989	Liver growth factor purified from human plasma is an albumin-bilirubin complex.	Bilirubin	61-70	myotrophin	Rattus norvegicus	6-19
2615647-1	1989	We have reported that a liver growth factor isolated from plasma of partially hepatectomized rats is an albumin-bilirubin complex.	Bilirubin	112-121	myotrophin	Rattus norvegicus	30-43
2615647-8	1989	Moreover, when albumin isolated from humans without hepatic pathology is incubated with bilirubin, the albumin-bilirubin complex formed mimics the activity of the human liver growth factor with respect to stimulation of DNA synthesis and the effects on the mitotic index of mouse hepatocytes in vivo.	Bilirubin	88-97	myotrophin	Rattus norvegicus	175-188
2795885-7	1989	Indirect bilirubin was 1.1 mg/dl and marked decrease of haptoglobin was found.	Bilirubin	9-18	haptoglobin	Homo sapiens	56-67
2615647-8	1989	Moreover, when albumin isolated from humans without hepatic pathology is incubated with bilirubin, the albumin-bilirubin complex formed mimics the activity of the human liver growth factor with respect to stimulation of DNA synthesis and the effects on the mitotic index of mouse hepatocytes in vivo.	Bilirubin	111-120	myotrophin	Rattus norvegicus	175-188
2615647-9	1989	We propose that this human liver growth factor is an albumin-bilirubin complex.	Bilirubin	61-70	myotrophin	Rattus norvegicus	33-46
2524193-2	1989	Antibodies raised against purified bilirubin UDPGT were used to study the transmembrane orientation of the protein to provide a molecular understanding of the UDPGT latency.	Bilirubin	35-44	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	159-164
2524193-5	1989	Treatment of the purified bilirubin UDPGT with peptide N-glycosidase F indicated that the enzyme was a glycoprotein.	Bilirubin	26-35	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	36-41
2524193-6	1989	A working model of the transmembrane topology of bilirubin UDPGT is described.	Bilirubin	49-58	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	59-64
2726110-0	1989	Serum albumin reserve for bilirubin binding during pregnancy in healthy women.	Bilirubin	26-35	albumin	Homo sapiens	0-13
2738521-2	1989	One of the parameters needed for the calculation of the bilirubin excess is the total bilirubin concentration in CSF.	Bilirubin	56-65	colony stimulating factor 2	Homo sapiens	113-116
2738521-2	1989	One of the parameters needed for the calculation of the bilirubin excess is the total bilirubin concentration in CSF.	Bilirubin	86-95	colony stimulating factor 2	Homo sapiens	113-116
2731280-1	1989	In a group of 13,449 neonates with a birth weight of 2500 g or more and without an incompatible constellation with the mothers in the Rh and ABO system in 17.7% of the children a rise od serum bilirubin above 205 mumol/l was found and 5.3% of the children were treated by phototherapy.	Bilirubin	193-202	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	141-144
2741296-3	1989	Enzymatic cleavage by hepatic beta-glucuronidase might result in higher unconjugated bilirubin (UCB) fractions in cholestatic disease.	Bilirubin	85-94	glucuronidase beta	Canis lupus familiaris	30-48
2504029-5	1989	Our study demonstrated that estimated total serum bilirubin concentration from forehead TcB readings was 0.56 +/- 0.35 mg/dl at birth, thereafter increasing to 6.8 +/- 0.5 mg/dl on day 1 and reaching a maximum of 12.6 +/- 2.5 mg/dl on day 6.	Bilirubin	50-59	pyruvate kinase M1/2	Homo sapiens	88-91
2494696-3	1989	Beta-glucuronidase of human or bacterial origin may lead to deconjugation of the bilirubin glucuronides in bile.	Bilirubin	81-90	glucuronidase beta	Homo sapiens	0-18
2930481-0	1989	Effect of the binding of bilirubin to either the first class or the second class of binding sites of the human serum albumin molecule on its photochemical reaction.	Bilirubin	25-34	albumin	Homo sapiens	111-124
2930481-1	1989	The kinetics of the photochemical changes of bilirubin were studied at a constant concentration of bilirubin bound either to the first class or to the second class of binding sites of the human serum albumin molecule.	Bilirubin	99-108	albumin	Homo sapiens	194-207
2930481-2	1989	The more the bilirubin binds to the first class of binding sites in the human serum albumin molecule, the more readily geometric photoequilibrium to give (ZE)-bilirubin takes place.	Bilirubin	13-22	albumin	Homo sapiens	78-91
2930481-2	1989	The more the bilirubin binds to the first class of binding sites in the human serum albumin molecule, the more readily geometric photoequilibrium to give (ZE)-bilirubin takes place.	Bilirubin	159-168	albumin	Homo sapiens	78-91
2930481-4	1989	When the serum bilirubin concentration is at low, safe, values bilirubin binds exclusively to the first class of binding sites and serves as an antioxidant [Onishi, Yamakawa &amp; Ogawa (1971) Perinatology 1, 373-379]; at these concentrations human serum albumin protects bilirubin from irreversible photodegradation by only allowing readily reversible geometric photoisomerization.	Bilirubin	15-24	albumin	Homo sapiens	249-262
2930481-4	1989	When the serum bilirubin concentration is at low, safe, values bilirubin binds exclusively to the first class of binding sites and serves as an antioxidant [Onishi, Yamakawa &amp; Ogawa (1971) Perinatology 1, 373-379]; at these concentrations human serum albumin protects bilirubin from irreversible photodegradation by only allowing readily reversible geometric photoisomerization.	Bilirubin	63-72	albumin	Homo sapiens	249-262
2930481-4	1989	When the serum bilirubin concentration is at low, safe, values bilirubin binds exclusively to the first class of binding sites and serves as an antioxidant [Onishi, Yamakawa &amp; Ogawa (1971) Perinatology 1, 373-379]; at these concentrations human serum albumin protects bilirubin from irreversible photodegradation by only allowing readily reversible geometric photoisomerization.	Bilirubin	63-72	albumin	Homo sapiens	249-262
2930481-5	1989	As the serum bilirubin concentration increases to high, and potentially dangerous, values, bilirubin binds to the second class of binding sites, and under these conditions human serum albumin seems to promote the photocyclization of bilirubin.	Bilirubin	13-22	albumin	Homo sapiens	178-191
2930481-5	1989	As the serum bilirubin concentration increases to high, and potentially dangerous, values, bilirubin binds to the second class of binding sites, and under these conditions human serum albumin seems to promote the photocyclization of bilirubin.	Bilirubin	91-100	albumin	Homo sapiens	178-191
2930481-5	1989	As the serum bilirubin concentration increases to high, and potentially dangerous, values, bilirubin binds to the second class of binding sites, and under these conditions human serum albumin seems to promote the photocyclization of bilirubin.	Bilirubin	91-100	albumin	Homo sapiens	178-191
2930481-6	1989	During irradiation human serum albumin seems to act by retaining low, useful, concentrations of bilirubin while facilitating irreversible photoisomerization of excess bilirubin.	Bilirubin	96-105	albumin	Homo sapiens	25-38
2930481-6	1989	During irradiation human serum albumin seems to act by retaining low, useful, concentrations of bilirubin while facilitating irreversible photoisomerization of excess bilirubin.	Bilirubin	167-176	albumin	Homo sapiens	25-38
2704588-1	1989	Beta-glucuronidase hydrolyzes glucuronic acid from bilirubin glucuronides.	Bilirubin	51-60	glucuronidase, beta	Rattus norvegicus	0-18
2704588-6	1989	Rats receiving saccharolactone excreted significantly less bilirubin in their bile, suggesting that inhibition of beta-glucuronidase decreased intestinal absorption of bilirubin.	Bilirubin	59-68	glucuronidase, beta	Rattus norvegicus	114-132
2704588-6	1989	Rats receiving saccharolactone excreted significantly less bilirubin in their bile, suggesting that inhibition of beta-glucuronidase decreased intestinal absorption of bilirubin.	Bilirubin	168-177	glucuronidase, beta	Rattus norvegicus	114-132
2736696-8	1989	The further investigations showed that excretion of bilirubin from the bile could be accelerated by Li Dan Ling, and after herbal administration, the cholesterol level in bile was lowered significantly; the liver blood flow in normal and jaundiced rats would be increased 30 to 90 min.	Bilirubin	52-61	NBL1, DAN family BMP antagonist	Homo sapiens	103-106
2504161-0	1989	Noninvolvement of surface lysine residues of bovine serum albumin in bilirubin binding.	Bilirubin	69-78	albumin	Homo sapiens	52-65
2504161-1	1989	Interaction of bilirubin with bovine serum albumin and its five succinylated forms was studied using fluorescence spectroscopy at two different ionic strengths i.e., 0.15 and 1.0 respectively.	Bilirubin	15-24	albumin	Homo sapiens	37-50
2464445-5	1989	Bilirubin and glucose decreased the CPA activity in serum by as much as 98% and 26%, respectively.	Bilirubin	0-9	carboxypeptidase A1	Homo sapiens	36-39
2712517-6	1989	Phototherapy was effective in reducing bilirubin levels in hyperbilirubinaemia associated with G6PD deficiency, the effectiveness being, however, less than in babies with non-haemolytic hyperbilirubinaemia (G6PD normal status).	Bilirubin	39-48	glucose-6-phosphate dehydrogenase	Homo sapiens	95-99
2910857-4	1989	HO-1 was purified from liver of rabbits treated with bromobenzene to near homogeneity with a specific activity of 8,270 nmol of bilirubin/mg/h and compared with a homogenous preparation of rat HO-1 with a specific activity of 6,220, also obtained from bromobenzene-treated animals.	Bilirubin	128-137	heme oxygenase 1	Oryctolagus cuniculus	0-4
2910857-6	1989	Rabbit HO-2 was partially purified from testis to a specific activity of 386 nmol of bilirubin/mg/h and compared with a purified preparation of rat testis HO-2 with a specific activity of 5,700.	Bilirubin	85-94	heme oxygenase 2	Oryctolagus cuniculus	7-11
2631543-4	1989	Therefore, to the extent that the HPL concentration reflects the rate constants for bilirubin transfer, an increased transplacental bilirubin gradient or an increased cord bilirubin concentration could not be explained by an impaired ability of the placenta to transfer bilirubin.	Bilirubin	84-93	galectin 1	Homo sapiens	34-37
2491935-2	1989	Bilirubin uridine diphosphoglucuronyl transferase (UDPGT) activity has been demonstrated in normal rat intestinal mucosa.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	10-49
2491935-2	1989	Bilirubin uridine diphosphoglucuronyl transferase (UDPGT) activity has been demonstrated in normal rat intestinal mucosa.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	51-56
2495935-7	1989	Secretin produced a specific increase of bilirubin glucuronidation, more evident in all nuclear fractions.	Bilirubin	41-50	secretin	Rattus norvegicus	0-8
2909046-0	1989	Serum albumin reserve for bilirubin binding during pregnancy in healthy women.	Bilirubin	26-35	albumin	Homo sapiens	0-13
2542677-2	1989	Guanase activity was correlated with GPT, GOT in acute viral hepatitis and chronic hepatitis, however, in liver cirrhosis and hepatocellular carcinoma it was correlated with total bilirubin as well as aminotransferases.	Bilirubin	180-189	guanine deaminase	Homo sapiens	0-7
2810003-4	1989	Since ACP1 probably acts as flavin mononucleotide phosphatase and is modulated by purine nucleotides, it is likely that enzymes of purine nucleotide metabolism (including ADA), ACP1 and flavoenzymes (including gluthatione reductase and enzymes of Krebs cycle), may represent a polygenic complex influencing bilirubin levels in the first few days of life.	Bilirubin	307-316	acid phosphatase 1	Homo sapiens	6-10
2810003-4	1989	Since ACP1 probably acts as flavin mononucleotide phosphatase and is modulated by purine nucleotides, it is likely that enzymes of purine nucleotide metabolism (including ADA), ACP1 and flavoenzymes (including gluthatione reductase and enzymes of Krebs cycle), may represent a polygenic complex influencing bilirubin levels in the first few days of life.	Bilirubin	307-316	adenosine deaminase	Homo sapiens	171-174
2909046-5	1989	The reduction in bilirubin binding capacity was partly dependent on the decreasing serum albumin concentration, but a reduction in the albumin molecule"s binding capability was also shown.	Bilirubin	17-26	albumin	Homo sapiens	83-96
3139000-0	1988	Treatment of rats with glucagon, vasointestinal peptide or secretin has a different effect on bilirubin and p-nitrophenol UDP-glucuronyltransferase.	Bilirubin	94-103	secretin	Rattus norvegicus	59-67
3143908-2	1988	Immunoblot analysis of microsomes from developing rat liver demonstrated that the deficiency in bilirubin and testosterone glucuronidation in the fetus was due to the absence of the UDPGT isoenzyme proteins responsible for these conjugations.	Bilirubin	96-105	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	182-187
3196053-1	1988	The incidence and severity (peak serum bilirubin concentration) of clinically detectable jaundice was determined retrospectively in 110 elution positive cases of ABO incompatibility.	Bilirubin	39-48	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	162-165
3192925-10	1988	Hyperthyroidism lowered the bilirubin UDP-glucuronosyltransferase activity, produced a decreased ratio of bilirubin di- to monoconjugates in bile and plasma, and a decreased ratio of conjugated to total bile pigment concentration in liver and in plasma.	Bilirubin	28-37	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	38-65
3182780-10	1988	These investigations suggest that the heme moiety of hemoglobin-haptoglobin in the organelles is detached from globin-haptoglobin and binds to another carrier protein prior to conversion of heme to bilirubin.	Bilirubin	198-207	haptoglobin	Rattus norvegicus	64-75
3142090-8	1988	Bile duct recanalization in jaundiced patients subjected to surgery was accompanied by a decrease in plasma PAI activity which paralleled the decrease in serum bilirubin levels.	Bilirubin	160-169	serpin family E member 1	Homo sapiens	108-111
3044714-4	1988	A positive correlation was found between bacterial population with beta-glucuronidase activity and the proportion of unconjugated bilirubin in bile in cases of brown pigment stones with cholangitis (P less than 0.05) but not in those without cholangitis despite the fact that bacterial species and population are similar regardless of the presence of cholangitis.	Bilirubin	130-139	glucuronidase beta	Homo sapiens	67-85
2454649-3	1988	S-HPFH could be distinguished from SS disease with a high HbF level by red cell count, HbF level, reticulocyte count, total haemoglobin and total bilirubin level in decreasing power of discrimination.	Bilirubin	146-155	HBFQTL2	Homo sapiens	2-6
3261984-4	1988	The return to normal values was not observed earlier than after 24 h. The effect of bilirubin on Fc receptor expression of splenic macrophages was less pronounced.	Bilirubin	84-93	Fc receptor	Mus musculus	97-108
3261984-6	1988	The changes in percentage of sIg+ and Thy 1.2+ lymphocytes reflect a change in the ratio of T to B cells in the peritoneal cavity, as bilirubin caused 40% increase in numbers of B cells and a similar decrease in numbers of T cells.	Bilirubin	134-143	thymus cell antigen 1, theta	Mus musculus	38-45
2847380-7	1988	The addition of the serum albumin into the incubation medium potentiates the inhibition effect of bilirubin, when the suspension of membrane particles is lighted in the presence of bilirubin.	Bilirubin	98-107	albumin	Homo sapiens	20-33
2847380-7	1988	The addition of the serum albumin into the incubation medium potentiates the inhibition effect of bilirubin, when the suspension of membrane particles is lighted in the presence of bilirubin.	Bilirubin	181-190	albumin	Homo sapiens	20-33
3410335-3	1988	When antithrombin III concentrate was infused at 12 hours there was a dose dependent improvement of the values of serum total bilirubin, SGPT, prothrombin time, peripheral platelet count, and plasma fibrinogen and coagulation factor VIIIC and of the histological degree of liver injury at 24 hours in the DMN group.	Bilirubin	126-135	serpin family C member 1	Rattus norvegicus	5-21
3183355-3	1988	A statistically significant association was found between HC II and AT (r = 0.79), NT (r = 0.71) and albumin (r = 0.66) (P less than 0.001), and there was a negative association between HC II and bilirubin (r = -0.55, P less than 0.001).	Bilirubin	196-205	serpin family D member 1	Homo sapiens	186-191
2451512-14	1988	Bilirubin, a product of haem catabolism, is shown to be a competitive inhibitor of the penultimate enzyme of the haem-biosynthetic pathway, protoporphyrinogen oxidase, with a calculated Ki of 25 microM.	Bilirubin	0-9	protoporphyrinogen oxidase	Mus musculus	140-166
3371867-4	1988	This result, in addition to our group"s recent identification of this liver growth factor as an albumin-bilirubin complex, strongly suggests that biliprotein is a liver growth factor.	Bilirubin	104-113	myotrophin	Rattus norvegicus	76-89
3371867-4	1988	This result, in addition to our group"s recent identification of this liver growth factor as an albumin-bilirubin complex, strongly suggests that biliprotein is a liver growth factor.	Bilirubin	104-113	myotrophin	Rattus norvegicus	169-182
3373428-1	1988	In light of our previous finding that gossypol competes effectively with bilirubin for the high affinity bilirubin binding site on human serum albumin, a study of the binding to albumin of four gossypol derivatives was undertaken.	Bilirubin	73-82	albumin	Homo sapiens	137-150
3373428-1	1988	In light of our previous finding that gossypol competes effectively with bilirubin for the high affinity bilirubin binding site on human serum albumin, a study of the binding to albumin of four gossypol derivatives was undertaken.	Bilirubin	105-114	albumin	Homo sapiens	137-150
3373428-3	1988	These periacylated gossylic nitriles bind to the high affinity bilirubin binding site on human serum albumin, but with dissociation constants approximately 30 times greater than that of gossypol.	Bilirubin	63-72	albumin	Homo sapiens	95-108
18584643-1	1988	The unbound bilirubin concentration and the enzymatic rate of bilirubin degradation by bilirubin oxidase in bilirubin-serum albumin solutions have been investigated experimentally and theoretically.	Bilirubin	12-21	albumin	Homo sapiens	118-131
18584643-1	1988	The unbound bilirubin concentration and the enzymatic rate of bilirubin degradation by bilirubin oxidase in bilirubin-serum albumin solutions have been investigated experimentally and theoretically.	Bilirubin	62-71	albumin	Homo sapiens	118-131
18584643-1	1988	The unbound bilirubin concentration and the enzymatic rate of bilirubin degradation by bilirubin oxidase in bilirubin-serum albumin solutions have been investigated experimentally and theoretically.	Bilirubin	62-71	albumin	Homo sapiens	118-131
18584643-2	1988	A stoichiometric bilirubin-serum albumin binding analysis shows that the unbound bilirubin concentration depends only on the molar ratio of the total bilirubin concentration to the total serum albumin concentration.	Bilirubin	17-26	albumin	Homo sapiens	27-40
18584643-2	1988	A stoichiometric bilirubin-serum albumin binding analysis shows that the unbound bilirubin concentration depends only on the molar ratio of the total bilirubin concentration to the total serum albumin concentration.	Bilirubin	81-90	albumin	Homo sapiens	27-40
18584643-2	1988	A stoichiometric bilirubin-serum albumin binding analysis shows that the unbound bilirubin concentration depends only on the molar ratio of the total bilirubin concentration to the total serum albumin concentration.	Bilirubin	81-90	albumin	Homo sapiens	187-200
18584643-2	1988	A stoichiometric bilirubin-serum albumin binding analysis shows that the unbound bilirubin concentration depends only on the molar ratio of the total bilirubin concentration to the total serum albumin concentration.	Bilirubin	81-90	albumin	Homo sapiens	27-40
18584643-2	1988	A stoichiometric bilirubin-serum albumin binding analysis shows that the unbound bilirubin concentration depends only on the molar ratio of the total bilirubin concentration to the total serum albumin concentration.	Bilirubin	81-90	albumin	Homo sapiens	187-200
18584643-3	1988	From the theoretical analysis and the measured unbound bilirubin concentrations, serum albumin may be modelled as a molecule having two binding sites, primary and secondary, with stoichiometric equilibrium constants of K(1) = 6 x 10(7)M(-1) and K(2) = 4.5 x 10(6)M(-1), respectively.	Bilirubin	55-64	albumin	Homo sapiens	81-94
18584643-4	1988	The rate of total bilirubin degradation in bilirubin-serum albumin mixtures is zero order.	Bilirubin	18-27	albumin	Homo sapiens	53-66
18584643-4	1988	The rate of total bilirubin degradation in bilirubin-serum albumin mixtures is zero order.	Bilirubin	43-52	albumin	Homo sapiens	53-66
18584643-6	1988	At a flow rate of 1 mL/min with a 8-mL reactor volume, a 50% bilirubin conversion per pass was observed with an inlet bilirubin concentration of 350muM and a serum albumin concentration of 500muM.	Bilirubin	61-70	albumin	Homo sapiens	158-171
3349890-2	1988	Our purpose is to develop a standard method for preparing the bile for beta-glucuronidase determination by removal of bile acids and conjugated bilirubin which interfere with its activity.	Bilirubin	144-153	glucuronidase beta	Homo sapiens	71-89
2829743-0	1988	Multiple binding of bilirubin to human serum albumin and cobinding with laurate.	Bilirubin	20-29	albumin	Homo sapiens	39-52
2829743-2	1988	Binding of bilirubin to defatted human serum albumin was investigated by a spectroscopic method, based upon a difference of light absorption spectrum for free and bound bilirubin.	Bilirubin	11-20	albumin	Homo sapiens	39-52
2829743-2	1988	Binding of bilirubin to defatted human serum albumin was investigated by a spectroscopic method, based upon a difference of light absorption spectrum for free and bound bilirubin.	Bilirubin	169-178	albumin	Homo sapiens	39-52
2448067-7	1988	This prognostic pattern persisted when adjusted for serum bilirubin concentration (AFP[+] 12 months vs AFP[-] 29 months, P = 0.01).	Bilirubin	58-67	alpha fetoprotein	Homo sapiens	83-86
3127803-0	1988	Bilirubin decreases phosphorylation of synapsin I, a synaptic vesicle-associated neuronal phosphoprotein, in intact synaptosomes from rat cerebral cortex.	Bilirubin	0-9	synapsin I	Rattus norvegicus	39-49
3127803-2	1988	Herein we present evidence for an inhibitory effect of bilirubin on both basal and depolarization-induced (50 mM KCl) phosphorylation of synapsin I, a synaptic vesicle-associated protein that may play a role in neurotransmitter release.	Bilirubin	55-64	synapsin I	Rattus norvegicus	137-147
3127803-6	1988	Our results show that addition of bilirubin to the medium significantly decreases 32P incorporation into synapsin I, both under basal and depolarizing conditions, in a time- and dose-dependent manner, significant effects being observed already at 10 microM bilirubin after 120-min incubation of the synaptosomes.	Bilirubin	34-43	synapsin I	Rattus norvegicus	105-115
3127803-6	1988	Our results show that addition of bilirubin to the medium significantly decreases 32P incorporation into synapsin I, both under basal and depolarizing conditions, in a time- and dose-dependent manner, significant effects being observed already at 10 microM bilirubin after 120-min incubation of the synaptosomes.	Bilirubin	257-266	synapsin I	Rattus norvegicus	105-115
3127803-7	1988	Separate analysis of the multiple phosphorylation sites in synapsin I showed that the phosphorylation of both the "head" and "tail" regions of the protein was decreased by bilirubin.	Bilirubin	172-181	synapsin I	Rattus norvegicus	59-69
3127803-10	1988	Our results thus suggest that bilirubin may achieve some of its reversible effects on the brain through inhibition of the phosphorylation of the synapsic vesicle-associated protein synapsin I.	Bilirubin	30-39	synapsin I	Rattus norvegicus	181-191
3220422-4	1988	On the contrary, FF administration decreased the inductive effect of PB on bilirubin UDP-GT activity.	Bilirubin	75-84	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	85-91
3042425-6	1988	Intrasplenic HTX, however, was more effective and resulted in a conjugated fraction of 17.7% of total biliary bilirubin (p less than 0.001).	Bilirubin	110-119	Zic family member 3	Homo sapiens	13-16
3667616-0	1987	Stopped-flow studies of spectral changes in bilirubin-human serum albumin following an alkaline pH jump and following binding of bilirubin.	Bilirubin	44-53	albumin	Homo sapiens	60-73
2451306-9	1987	PK and alpha 2-M correlated positively with each other and albumin and negatively with creatinine, bilirubin and CyA (2 p less than 0.01).	Bilirubin	99-108	alpha-2-macroglobulin	Homo sapiens	7-16
2825716-3	1987	UDP-GT activity towards bilirubin was induced 3-fold.	Bilirubin	24-33	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	0-6
3435438-1	1987	Bilirubin binding to neuraminidase- and phospholipase-treated membranes.	Bilirubin	0-9	neuraminidase 1	Homo sapiens	21-34
3667616-0	1987	Stopped-flow studies of spectral changes in bilirubin-human serum albumin following an alkaline pH jump and following binding of bilirubin.	Bilirubin	129-138	albumin	Homo sapiens	60-73
3663704-2	1987	Incorporation of bilirubin into the micelles is accompanied by specific shifts of bilirubin vinyl and bridgehead protons and the C18 and C19 methyl groups of the steroid.	Bilirubin	17-26	Bardet-Biedl syndrome 9	Homo sapiens	129-132
3479781-3	1987	Bilirubin ditaurine (BR-DT), a water-soluble model compound of conjugated bilirubin, completely prevents the peroxyl radical-induced oxidation of phosphatidylcholine in either multilamellar liposomes or micelles.	Bilirubin	74-83	bromodomain testis associated	Homo sapiens	0-26
3672034-3	1987	The LCAT mass in plasma correlated positively with serum albumin (r = 0.69, p less than 0.001) and pre-albumin (r = 0.77, p less than 0.001) and negatively with serum bilirubin (r = -0.42, p less than 0.01) and bile salts (r = -0.43, p less than 0.01), thus reflecting the severity of liver disease and liver protein synthesizing capacity.	Bilirubin	167-176	lecithin-cholesterol acyltransferase	Homo sapiens	4-8
3115856-4	1987	The ratio of glucuronidated to unconjugated BR 15 min after injection of albumin-bound BR into the tail vein appears to correlate negatively with the liver microsomal beta G activity.	Bilirubin	44-46	glucuronidase, beta	Rattus norvegicus	167-173
3653135-7	1987	It is suggested that the combination of quantitative elution test, bilirubin concentration and direct Coombs test in the cord blood is useful for an early diagnosis of ABO-HDN.	Bilirubin	67-76	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	168-171
3608728-3	1987	Inflammatory cells such as polymorphonuclear leukocytes and lymphocytes appearing with the presence of brown pigment gallstones and inflammation in biliary tract was shown to effect deconjugation of bilirubin conjugates in bile and contribute to their formation in addition to that of bacterial beta-glucuronidase.	Bilirubin	199-208	glucuronidase beta	Homo sapiens	295-313
3607043-3	1987	Malate dehydrogenase was inhibited at very low concentrations of bilirubin and showed competitive inhibition with respect to coenzyme of 2 microM, while the cytosolic form of this enzyme exhibited a 15 microM inhibition constant.	Bilirubin	65-74	malic enzyme 2	Homo sapiens	0-20
3593743-0	1987	Influence of succinylation of bovine serum albumin on its conformation and bilirubin binding.	Bilirubin	75-84	albumin	Homo sapiens	37-50
3593743-1	1987	In order to investigate the role of lysine residues in the interaction of bilirubin with bovine serum albumin, five succinylated preparations of albumin, namely: 23%, 39%, 49%, 55% and 87%, were prepared, and their conformational and bilirubin-binding properties were studied by the techniques of gel filtration, ultraviolet and visible spectroscopy, and fluorescence quenching.	Bilirubin	74-83	albumin	Homo sapiens	96-109
3493746-5	1987	We found the following: the rate of progression of PSC is highly variable; an asymptomatic presentation may not indicate a more favorable outcome or prolonged survival; a serum bilirubin value of four times or more the upper limit of normal, particularly if sustained so as to exclude a reversible cause, is indicative of late-stage disease with a likelihood of subsequent poor outcome and death; and variceal hemorrhage may occur before the terminal stage of the disease.	Bilirubin	177-186	PSC	Homo sapiens	51-54
3114967-4	1987	UDP-Glucuronosyltransferase (UDP-GT) activity towards 4"-hydroxy-DAB was partially depressed during the regeneration period, but the depression was considerably less than that for bilirubin.	Bilirubin	180-189	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	29-35
3114967-7	1987	In Gunn rats, microsomal UDP-GT activity towards bilirubin was undetectable, whereas transferase activity toward 4-nitrophenol was 50% of normal.	Bilirubin	49-58	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	25-31
3110589-2	1987	IgG prepared from this antiserum exhibited specificity for only two UDPGT isoenzymes (bilirubin and phenol) on immunoblot analysis of Wistar rat liver microsomes.	Bilirubin	86-95	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	68-73
3110938-4	1987	Apolipoprotein A-I concentrations in plasma correlated positively with serum albumin (r = 0.55, p less than 0.001) and prealbumin (r = 0.57, p less than 0.001) and negatively with serum bilirubin (r = -0.47, p less than 0.01) and bile salts (r = -0.54, p less than 0.001).	Bilirubin	186-195	apolipoprotein A1	Homo sapiens	0-18
3100574-4	1987	UDPGT isoform V (elution pH 7.5) from Wistar (RHA) rats is active toward bilirubin and 4"-hydroxydimethylaminoazobenzene.	Bilirubin	73-82	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-5
3452425-4	1987	The ability of the oligopeptide-resins to retain adsorbed bilirubin in the presence of BSA follows the order (Arg)5(Ala)3- greater than (Arg)2(Ala)3- greater than (Lys)5(Ala)3- = His(Arg)2(Ala)3-resin.	Bilirubin	58-67	arginase 2	Homo sapiens	119-121
3828413-0	1987	Wavelength dependence of the geometric and structural photoisomerization of bilirubin bound to human serum albumin.	Bilirubin	76-85	albumin	Homo sapiens	101-114
3828413-2	1987	We describe in vitro studies on the wavelength dependence for the geometric (delta 4Z, delta 15Z----delta 4Z, delta 15E) and structural (endovinyl cyclization) photoisomerization of bilirubin bound to human serum albumin by a high performance liquid chromatography method.	Bilirubin	182-191	albumin	Homo sapiens	207-220
3574276-9	1987	We confirmed that the increase of unconjugated bilirubin caused by the high bacterial beta-Glucuronidase activity was the most important factor in the formation of calcium bilirubinate gallstone.	Bilirubin	47-56	glucuronidase beta	Homo sapiens	86-104
3574276-9	1987	We confirmed that the increase of unconjugated bilirubin caused by the high bacterial beta-Glucuronidase activity was the most important factor in the formation of calcium bilirubinate gallstone.	Bilirubin	164-184	glucuronidase beta	Homo sapiens	86-104
3101703-4	1987	No induction of renal UDPGT was observed after phenobarbital treatment, but renal bilirubin UDPGT activity was specifically induced after treatment of rats with clofibrate.	Bilirubin	82-91	UDP glucuronosyltransferase family 2 member B15	Rattus norvegicus	92-97
3101703-9	1987	Glucuronidation of bilirubin by purified renal UDPGT preparations required the presence of phospholipid, the activity being further enhanced by incubation with rat lung microsomes.	Bilirubin	19-28	UDP glucuronosyltransferase family 2 member B15	Rattus norvegicus	47-52
3452425-4	1987	The ability of the oligopeptide-resins to retain adsorbed bilirubin in the presence of BSA follows the order (Arg)5(Ala)3- greater than (Arg)2(Ala)3- greater than (Lys)5(Ala)3- = His(Arg)2(Ala)3-resin.	Bilirubin	58-67	arginase 2	Homo sapiens	146-148
2441926-0	1987	Immunochemical comparisons of proteins that bind heme and bilirubin: human serum albumin, alpha-fetoprotein and glutathione S-transferases from liver, placenta and erythrocyte.	Bilirubin	58-67	albumin	Homo sapiens	75-88
3096339-5	1986	UDPGT activity towards bilirubin, although induced by PB, can be detected in hepatic, intestinal and renal microsomes.	Bilirubin	23-32	UDP glucuronosyltransferase family 2 member B15	Rattus norvegicus	0-5
3593479-2	1987	High plasma B12 levels significantly correlate (P less than 0.0001) with standard liver function tests, e.g. bilirubin, cholylglycine, alkaline phosphatase, AST and prothrombin time as an index of the severity of hepatic damage.	Bilirubin	109-118	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	12-15
3558567-0	1986	Reaction of bilirubin glucuronides with serum albumin.	Bilirubin	12-21	albumin	Homo sapiens	40-53
3811284-0	1986	[Bilirubin binding to glycosylated human serum albumin].	Bilirubin	1-10	albumin	Homo sapiens	41-55
3100303-0	1986	Human biliary beta-glucuronidase: correlation of its activity with deconjugation of bilirubin in the bile.	Bilirubin	84-93	glucuronidase beta	Homo sapiens	14-32
3100303-3	1986	Mean endogenous beta-glucuronidase activities at pH 5.2 were 12.0, 15.5, 44.5 and 147.7 nmol min-1 ml-1 for C, CS, black PS, and Brown PS, respectively, which correlated well with the degree of deconjugation of bilirubin in gall-bladder and hepatic biles and with the rate of deconjugation of hepatic bile incubated at 37 degrees C. Only four biles in brown PS exhibited bacterial enzyme activity.	Bilirubin	211-220	glucuronidase beta	Homo sapiens	16-34
3100303-4	1986	We concluded that though bacterial beta-glucuronidase might be responsible for deconjugation of bilirubin in some patients in brown PS, endogenous biliary beta-glucuronidase could play a key role in the pathogenesis of pigment cholelithiasis.	Bilirubin	96-105	glucuronidase beta	Homo sapiens	35-53
3963818-2	1986	Similarities of the chemical structures of hydroxymethylbilane, an intermediate in the biosynthesis of uroporphyrinogen, to bilirubin prompted investigations of the effect of bilirubin on the activity of uroporphyrinogen I synthase (porphobilinogen deaminase, EC 4.3.1.8) and the biosynthesis of heme.	Bilirubin	124-133	hydroxymethylbilane synthase	Rattus norvegicus	204-231
3795542-0	1986	[Binding of bilirubin to serum albumin in Crigler-Najjar syndrome, type I].	Bilirubin	12-21	albumin	Homo sapiens	25-38
3526065-5	1986	Further, the "index" revealed a significant proportional correlation with the total bilirubin and direct bilirubin, and also a significant inversely proportional correlation with the plasma AT III, suggesting that the "index" tends to become higher as liver function decreases.	Bilirubin	84-93	serpin family C member 1	Homo sapiens	190-196
3526065-5	1986	Further, the "index" revealed a significant proportional correlation with the total bilirubin and direct bilirubin, and also a significant inversely proportional correlation with the plasma AT III, suggesting that the "index" tends to become higher as liver function decreases.	Bilirubin	105-114	serpin family C member 1	Homo sapiens	190-196
3087977-4	1986	The enzyme activity of the cytosolic LTC4-binding protein was inhibited by submicromolar quantities of unlabeled LTC4, and the binding activity for [3H]LTC4 was blocked by the ligandin substrates, hematin and bilirubin.	Bilirubin	209-218	glutathione S-transferase alpha 2	Rattus norvegicus	176-184
3963818-2	1986	Similarities of the chemical structures of hydroxymethylbilane, an intermediate in the biosynthesis of uroporphyrinogen, to bilirubin prompted investigations of the effect of bilirubin on the activity of uroporphyrinogen I synthase (porphobilinogen deaminase, EC 4.3.1.8) and the biosynthesis of heme.	Bilirubin	175-184	hydroxymethylbilane synthase	Rattus norvegicus	204-231
3963818-3	1986	Bilirubin was found to be a reversible, noncompetitive inhibitor of uroporphyrinogen I synthase.	Bilirubin	0-9	hydroxymethylbilane synthase	Rattus norvegicus	68-95
3963818-12	1986	These results indicate that bilirubin is capable of depressing the biosynthesis of rat hepatic heme and thus cytochrome P-450-mediated drug metabolism by inhibition of the formation of uroporphyrinogen.	Bilirubin	28-37	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	109-125
2869347-6	1986	In the breast-fed babies, serum bilirubin levels were related to concentrations of beta-glucuronidase in breast milk on both days 3 and 21 and to levels of faecal beta-glucuronidase on day 21.	Bilirubin	32-41	glucuronidase beta	Homo sapiens	83-101
3955808-4	1986	A typical least-squares equation for quantifying bilirubin in the presence of hemoglobin and bovine serum albumin from multi-wavelength second-derivative data is y(computed) = 0.999x(prepared) + 0.00 mg/L.	Bilirubin	49-58	albumin	Homo sapiens	100-113
3952671-7	1986	VIP also caused a dose-related inhibition of the maximal response to CCK-8, decreasing bilirubin output from 39 +/- 8 to 15 +/- 3 mg/hr (p less than 0.05).	Bilirubin	87-96	vasoactive intestinal peptide	Canis lupus familiaris	0-3
3952671-7	1986	VIP also caused a dose-related inhibition of the maximal response to CCK-8, decreasing bilirubin output from 39 +/- 8 to 15 +/- 3 mg/hr (p less than 0.05).	Bilirubin	87-96	cholecystokinin	Canis lupus familiaris	69-72
2869347-6	1986	In the breast-fed babies, serum bilirubin levels were related to concentrations of beta-glucuronidase in breast milk on both days 3 and 21 and to levels of faecal beta-glucuronidase on day 21.	Bilirubin	32-41	glucuronidase beta	Homo sapiens	163-181
2869347-7	1986	In 4 additional babies whose feeds were temporarily changed from breast milk to formula milk because of hyperbilirubinaemia there was a striking decrease in faecal beta-glucuronidase activity coincident with a fall in serum bilirubin.	Bilirubin	109-118	glucuronidase beta	Homo sapiens	164-182
3700514-2	1986	Biliary bilirubin mono- and diglucuronide can be analysed directly on a C18 reversed-phase column with acetonitrile-dimethyl sulphoxide-0.1 M ammonium acetate (pH 5.16) (50:50:85, v/v/v) as mobile phase.	Bilirubin	8-17	Bardet-Biedl syndrome 9	Homo sapiens	72-75
3753975-11	1986	Competition studies between heme and Sn-protoporphyrin and between bilirubin and Sn-protoporphyrin indicate that Sn-protoporphyrin distributes differently among porphyrin-binding sites on serum albumin than does heme and that it is also not an effective competitor with bilirubin for bilirubin-binding sites.	Bilirubin	67-76	albumin	Homo sapiens	188-201
3753975-11	1986	Competition studies between heme and Sn-protoporphyrin and between bilirubin and Sn-protoporphyrin indicate that Sn-protoporphyrin distributes differently among porphyrin-binding sites on serum albumin than does heme and that it is also not an effective competitor with bilirubin for bilirubin-binding sites.	Bilirubin	270-279	albumin	Homo sapiens	188-201
3753975-11	1986	Competition studies between heme and Sn-protoporphyrin and between bilirubin and Sn-protoporphyrin indicate that Sn-protoporphyrin distributes differently among porphyrin-binding sites on serum albumin than does heme and that it is also not an effective competitor with bilirubin for bilirubin-binding sites.	Bilirubin	270-279	albumin	Homo sapiens	188-201
3484933-1	1986	Interferon-beta (GKT-beta) was administered to a patient with adult T-cell leukemia (ATL), presumably of acute type, with a marked organ infiltration and increases in serum calcium, LDH and bilirubin.	Bilirubin	190-199	interferon beta 1	Homo sapiens	0-15
3484933-1	1986	Interferon-beta (GKT-beta) was administered to a patient with adult T-cell leukemia (ATL), presumably of acute type, with a marked organ infiltration and increases in serum calcium, LDH and bilirubin.	Bilirubin	190-199	glycerol kinase 3 pseudogene	Homo sapiens	17-25
3079757-3	1986	HO-1 was purified to homogeneity and exhibited a specific activity of up to 4000 nmol of bilirubin/mg of protein/h.	Bilirubin	89-98	heme oxygenase 1	Rattus norvegicus	0-4
3510529-2	1986	Urinary kallikrein excretion in cirrhotics showed a positive correlation with serum albumin, indocyanine green disappearance rate, cholinesterase, and prothrombin, and an inverse correlation with bilirubin.	Bilirubin	196-205	kallikrein related peptidase 4	Homo sapiens	8-18
3079757-4	1986	HO-2 was partially purified to a specific activity of 250 nmol of bilirubin/mg of protein/h.	Bilirubin	66-75	heme oxygenase 2	Rattus norvegicus	0-4
3757585-0	1986	Displacement effect of ceftriaxone on bilirubin bound to human serum albumin.	Bilirubin	38-47	albumin	Homo sapiens	63-76
3559144-1	1986	Isomers of bilirubin glucuronide with the bilirubin acyl group attached to the C1-, C2-, C3- and C4-positions of the glucuronyl residue are present in bile of patients with extrahepatic cholestasis, whereas in normal bile only C1-isomers are found.	Bilirubin	11-20	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	79-91
3757585-1	1986	The effects of ceftriaxone, a "third-generation" cephalosporin, on bilirubin-serum albumin complexes were investigated.	Bilirubin	67-76	albumin	Homo sapiens	77-90
3559144-1	1986	Isomers of bilirubin glucuronide with the bilirubin acyl group attached to the C1-, C2-, C3- and C4-positions of the glucuronyl residue are present in bile of patients with extrahepatic cholestasis, whereas in normal bile only C1-isomers are found.	Bilirubin	42-51	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	79-91
3006193-0	1986	Effect of bilirubin on the spectrophotometric and radionuclide assay for serum angiotensin-converting enzyme.	Bilirubin	10-19	angiotensin I converting enzyme	Homo sapiens	79-108
3006193-1	1986	The effect of bilirubin on serum angiotensin-converting enzyme (ACE) activity was studied with spectrophotometric and radionuclide assays.	Bilirubin	14-23	angiotensin I converting enzyme	Homo sapiens	33-62
3006193-1	1986	The effect of bilirubin on serum angiotensin-converting enzyme (ACE) activity was studied with spectrophotometric and radionuclide assays.	Bilirubin	14-23	angiotensin I converting enzyme	Homo sapiens	64-67
3006193-2	1986	In the spectrophotometric assay addition of bilirubin to normal serum from dog, mouse, and human produced a dose-related inhibition of ACE activity.	Bilirubin	44-53	angiotensin I converting enzyme	Homo sapiens	135-138
3006193-4	1986	Serum from icteric patients with elevated bilirubin was also associated with a reduction in ACE activity in the spectrophotometric assay.	Bilirubin	42-51	angiotensin I converting enzyme	Homo sapiens	92-95
3006193-5	1986	A 50% decrease in ACE activity in these samples was associated with a serum bilirubin of approximately 220 mg/L.	Bilirubin	76-85	angiotensin I converting enzyme	Homo sapiens	18-21
3006193-7	1986	The use of a radionuclide assay for serum ACE in clinical samples offers the advantage of less interference from serum bilirubin.	Bilirubin	119-128	angiotensin I converting enzyme	Homo sapiens	42-45
3911493-1	1985	The enzymatic activity of bacterial beta-glucuronidase plays an essential role in the formation of calcium bilirubinate in bile.	Bilirubin	99-119	glucuronidase beta	Homo sapiens	36-54
3868996-2	1985	The k-value, a measure of endogenous bilirubin clearance, is affected by cholangitis, alanine aminotransferase, pre-intervention bilirubin levels and the patient"s sex.	Bilirubin	37-46	glutamic--pyruvic transaminase	Homo sapiens	86-110
3940341-0	1986	Increased immunoreactive erythropoietin in cord plasma and neonatal bilirubin production in normal term infants after labor.	Bilirubin	68-77	erythropoietin	Homo sapiens	25-39
3911493-7	1985	It can be said that beta-glucuronidase is essential for the formation of calcium bilirubinate gallstone at physiologic pH.	Bilirubin	73-93	glucuronidase beta	Homo sapiens	20-38
4064569-6	1985	Biliary bile acid and bilirubin outputs were significantly augmented only when plasma concentrations of CCK-8 were greater than 5 pmol/l.	Bilirubin	22-31	cholecystokinin	Homo sapiens	104-107
4085662-4	1985	The stoichiometric ratio of high affinity site for bilirubin to GST molecule differs amongst isozymes.	Bilirubin	51-60	hematopoietic prostaglandin D synthase	Rattus norvegicus	64-67
4085662-5	1985	The anionic form of GST bound two bilirubin per molecule whereas cationic GSTs bound only one bilirubin per two subunits.	Bilirubin	34-43	hematopoietic prostaglandin D synthase	Rattus norvegicus	20-23
4003060-0	1985	Hematin and bilirubin binding to human serum albumin and newborn serum.	Bilirubin	12-21	albumin	Homo sapiens	39-52
2863207-6	1985	Multivariate regression and partial correlation analysis showed that fibronectin was independently correlated with serum albumin, gamma-glutamyl transpeptidase and total serum bilirubin explaining that the prognostic value of albumin diminished and that the prognostic value of total serum bilirubin and gamma-glutamyl transpeptidase disappeared when combined with serum fibronectin.	Bilirubin	176-185	fibronectin 1	Homo sapiens	69-80
2863207-6	1985	Multivariate regression and partial correlation analysis showed that fibronectin was independently correlated with serum albumin, gamma-glutamyl transpeptidase and total serum bilirubin explaining that the prognostic value of albumin diminished and that the prognostic value of total serum bilirubin and gamma-glutamyl transpeptidase disappeared when combined with serum fibronectin.	Bilirubin	290-299	fibronectin 1	Homo sapiens	69-80
4031059-0	1985	Identification of gallbladder mucin-bilirubin complex in human cholesterol gallstone matrix.	Bilirubin	36-45	LOC100508689	Homo sapiens	30-35
4031059-10	1985	Sepharose 2B chromatography revealed that 2ME released a high molecular weight mucin-bilirubin complex as well as unbound pigment from the insoluble matrix.	Bilirubin	85-94	LOC100508689	Homo sapiens	79-84
4031059-14	1985	This study describes, for the first time, the isolation of a bilirubin-mucin complex in the insoluble matrix of human cholesterol gallstones.	Bilirubin	61-70	LOC100508689	Homo sapiens	71-76
3884478-3	1985	Patients with high urine B2MG concentration had markedly higher serum bilirubin than did patients with normal values (31 +/- 3 vs. 10 +/- 8 mg%, p less than 0.001), whereas prothrombin activity, serum albumin and serum B2MG concentration were similar.	Bilirubin	70-79	beta-2-microglobulin	Homo sapiens	25-29
3923605-3	1985	Concentrations of apolipoproteins A-I and A-II were low in patients with cholestatic liver disease and A-I levels correlated inversely with the severity of liver disease as measured by bilirubin levels (r = -0.66).	Bilirubin	185-194	apolipoprotein A1	Homo sapiens	18-46
3923605-6	1985	A close relation existed between the ratio of apolipoprotein E to apolipoprotein A-I and plasma bile salt concentration (r = 0.80, p less than 0.01) and serum bilirubin (r = 0.76, p less than 0.01).	Bilirubin	159-168	apolipoprotein E	Homo sapiens	46-62
3977868-2	1985	The present study was performed to elucidate why the photochemical reaction of (ZZ)-bilirubin bound to human serum albumin is singularly selective, and only one of the two (EZ)- and (ZE)-bilirubins, the (ZE)-isomer, is produced.	Bilirubin	84-93	albumin	Homo sapiens	109-122
3977868-2	1985	The present study was performed to elucidate why the photochemical reaction of (ZZ)-bilirubin bound to human serum albumin is singularly selective, and only one of the two (EZ)- and (ZE)-bilirubins, the (ZE)-isomer, is produced.	Bilirubin	187-197	albumin	Homo sapiens	109-122
3977868-5	1985	It was concluded that (EZ)-bilirubin photochemically undergoes (EZ)-cyclization, i.e. structural photoisomerization, while bound to its high-affinity site on human serum albumin, and is an intermediate in the transformation of (ZZ)-bilirubin into (EZ)-cyclobilirubin.	Bilirubin	27-36	albumin	Homo sapiens	164-177
3884478-4	1985	A "threshold" serum bilirubin concentration of about 23 mg% differentiated patients with normal and high urine B2MG values.	Bilirubin	20-29	beta-2-microglobulin	Homo sapiens	111-115
3982872-3	1985	Reversion of BR photoisomers (identical to photobilirubin, PBR) back to native BR is demonstrated for several laser lines by irradiating PBR/BR mixtures with wavelengths greater than the excitation wavelengths.	Bilirubin	13-15	translocator protein	Homo sapiens	59-62
3968978-5	1985	This infusion of CCK induced significant increases in trypsin secretion from 0.5 +/- 0.1 to 1.4 +/- 0.2 KU/15 min (p less than 0.005) and in bilirubin output from 1.6 +/- 0.7 to 30.3 +/- 8.0 mumol/15 min (p less than 0.05).	Bilirubin	141-150	cholecystokinin	Homo sapiens	17-20
3982872-3	1985	Reversion of BR photoisomers (identical to photobilirubin, PBR) back to native BR is demonstrated for several laser lines by irradiating PBR/BR mixtures with wavelengths greater than the excitation wavelengths.	Bilirubin	13-15	translocator protein	Homo sapiens	137-140
2988654-9	1985	These studies indicate that, in the puppy, (1) the in vitro activities of P-450, G6P and GT are immature at birth and develop during postnatal life; (2) as in other species, bilirubin and p-nitrophenol may be conjugated in the dog liver by two functionally distinct GT.	Bilirubin	174-183	glucose-6-phosphatase catalytic subunit 1	Canis lupus familiaris	81-84
2869747-5	1985	Maximal elevation of gamma-GT activity was about twice that of AP and of the bilirubin content.	Bilirubin	77-86	gamma-glutamyltransferase 1	Rattus norvegicus	21-29
4029818-0	1985	The effect of bilirubin on the Fc receptor expression and phagocytic activity of mouse peritoneal macrophages.	Bilirubin	14-23	Fc receptor	Mus musculus	31-42
2935199-6	1985	The release of beta-thromboglobulin, induced by close cell-to-cell contact, was lower in bilirubin- and light-treated platelets with respect to controls.	Bilirubin	89-98	pro-platelet basic protein	Homo sapiens	15-35
3987656-1	1985	beta-Glucuronidase (EC 3.2.1.31) was purified from human liver and its activity was determined by enzyme kinetic method employing phenolphthalein glucuronic acid (PGA) and conjugated bilirubin, primarily bilirubin diglucuronide purified from human bile, as substrates in the absence or presence of D-glucaro-1,4-lactone.	Bilirubin	183-192	glucuronidase beta	Homo sapiens	0-18
3987656-1	1985	beta-Glucuronidase (EC 3.2.1.31) was purified from human liver and its activity was determined by enzyme kinetic method employing phenolphthalein glucuronic acid (PGA) and conjugated bilirubin, primarily bilirubin diglucuronide purified from human bile, as substrates in the absence or presence of D-glucaro-1,4-lactone.	Bilirubin	204-213	glucuronidase beta	Homo sapiens	0-18
3966926-9	1985	The addition of bilirubin to partially purified cytosolic glutathione S-transferase decreased the basic character of glutathione S-transferases B and C. In conclusion, chloroform caused a release of hepatic cytosolic glutathione S-transferases into serum.	Bilirubin	16-25	hematopoietic prostaglandin D synthase	Rattus norvegicus	58-83
4029818-2	1985	Intraperitoneally administered bilirubin influenced the expression of Fc receptors for IgM, IgG2B, IgA and IgE, whereas the expression of other receptors as well as the phagocytic activity of peritoneal macrophages remained unchanged.	Bilirubin	31-40	immunoglobulin heavy constant gamma 2B	Mus musculus	92-97
2984453-6	1985	Vasopressin-stimulated sodium transport, as reflected by short circuit current (SCC), was inhibited by 18 +/- 6% in the presence of bilirubin (N = 10; P less than 0.02).	Bilirubin	132-141	arginine vasopressin	Rattus norvegicus	0-11
3840503-7	1985	Purified preparations of bilitranslocase, a liver plasma-membrane protein involved in bilirubin and sulfobromophthalein (BSP) transport, specifically bound NA and the drug competitively inhibited BSP uptake in rat liver plasma membrane vesicles (Ki = 50 nM).	Bilirubin	86-95	ceruloplasmin	Rattus norvegicus	25-40
2984453-11	1985	These findings show that short-term exposure to bilirubin exerts a tissue-specific effect on the vasopressin-stimulated active transport of sodium but has no effect on the vasopressin-induced fluxes of water and urea.	Bilirubin	48-57	arginine vasopressin	Rattus norvegicus	97-108
6705445-8	1984	This correlated in part with severity of disease, with r = 0.723 between t1/2 beta and the serum bilirubin levels.	Bilirubin	97-106	interleukin 1 receptor like 1	Homo sapiens	73-82
2413517-0	1985	Presence of three different binding sites for retinoids, bilirubin and estrogen or arachidonic acid on rat alpha-fetoprotein.	Bilirubin	57-66	alpha-fetoprotein	Rattus norvegicus	107-124
2413517-2	1985	This site overlaps with a high affinity arachidonic acid binding site (Ka = 1 X 10(7) M-1) and with a tryptophan methyl ester binding site, AFP also possesses a second site able to bind retinoids with a Ka = 1 X 10(6) M-1, and a third site for the binding of bilirubin (Ka = 1 X 10(6) M-1).	Bilirubin	259-268	alpha-fetoprotein	Rattus norvegicus	140-143
6480603-9	1984	Bilirubin and bromosulfophthalein inhibited mucin-induced ANS fluorescence, but bile acids did not.	Bilirubin	0-9	mucin 1, cell surface associated	Bos taurus	44-49
6384000-0	1984	Does Z-protein have a role in transport of bilirubin and bromosulfophthalein by isolated perfused rat liver?	Bilirubin	43-52	fatty acid binding protein 1	Rattus norvegicus	5-14
6384000-3	1984	Other studies in isolated perfused rat liver revealed that selectively increased cytosolic ligandin concentration, following phenobarbital treatment or thyroidectomy, directly correlated with net bilirubin uptake which resulted from reduced bilirubin efflux.	Bilirubin	196-205	glutathione S-transferase alpha 2	Rattus norvegicus	91-99
6384000-3	1984	Other studies in isolated perfused rat liver revealed that selectively increased cytosolic ligandin concentration, following phenobarbital treatment or thyroidectomy, directly correlated with net bilirubin uptake which resulted from reduced bilirubin efflux.	Bilirubin	241-250	glutathione S-transferase alpha 2	Rattus norvegicus	91-99
6434394-6	1984	When supersaturation occurs, usually due to increased concentrations of bilirubinate anion, nucleation may be initiated by binding of calcium bilirubinate to mucin glycoproteins in bile.	Bilirubin	134-154	LOC100508689	Homo sapiens	158-163
6430775-0	1984	Enhancement by secretin of the apparently maximal hepatic transport of bilirubin in the rat.	Bilirubin	71-80	secretin	Rattus norvegicus	15-23
6430775-3	1984	When secretin was administered during an already established bilirubin-Tm condition, it increased bile flow and bilirubin-Tm by 15 to 20% over a 30- to 50-min period.	Bilirubin	61-70	secretin	Rattus norvegicus	5-13
6430775-3	1984	When secretin was administered during an already established bilirubin-Tm condition, it increased bile flow and bilirubin-Tm by 15 to 20% over a 30- to 50-min period.	Bilirubin	112-121	secretin	Rattus norvegicus	5-13
6430775-5	1984	When secretin was given for 90 min before bilirubin loading, it enhanced biliary bilirubin concentration and output, largely as diglucuronides.	Bilirubin	42-51	secretin	Rattus norvegicus	5-13
6430775-5	1984	When secretin was given for 90 min before bilirubin loading, it enhanced biliary bilirubin concentration and output, largely as diglucuronides.	Bilirubin	81-90	secretin	Rattus norvegicus	5-13
6518065-2	1984	Evidence for the possible association of cord blood erythropoietin levels and postnatal bilirubin production in infants of mothers with abnormalities of gestational glucose metabolism.	Bilirubin	88-97	erythropoietin	Homo sapiens	52-66
6706980-7	1984	Hemin affinity was unaltered by glycosylation of albumin in vivo, whereas the affinity of bilirubin for glycosylated albumin was about 50% its value for the nonglycosylated form.	Bilirubin	90-99	albumin	Homo sapiens	117-124
6201166-0	1984	Interaction of retinoids and bilirubin with the binding of arachidonic acid to human alpha-fetoprotein.	Bilirubin	29-38	alpha fetoprotein	Homo sapiens	85-102
6371239-2	1984	For this purpose the model of tuberculin hypersensitivity in rabbits was employed and the effect of bilirubin was studied on the migration inhibition test and its two main phases; the process of MIF production and the effect of already preformed MIF on the effector system.	Bilirubin	100-109	macrophage migration inhibitory factor	Oryctolagus cuniculus	195-198
6371239-3	1984	It was found that the neutralizing effect of bilirubin on the migration inhibition (caused by specific antigen) was due to the effect of bilirubin on the process of MIF production.	Bilirubin	45-54	macrophage migration inhibitory factor	Oryctolagus cuniculus	165-168
6371239-3	1984	It was found that the neutralizing effect of bilirubin on the migration inhibition (caused by specific antigen) was due to the effect of bilirubin on the process of MIF production.	Bilirubin	137-146	macrophage migration inhibitory factor	Oryctolagus cuniculus	165-168
32111109-6	1984	It is hypothesized that phenotypic differences in bilirubin binding, and in competitive binding by dietary constituents, by albumin influences both these results and the nonrandom distribution of AlB mac in Asian macaques.	Bilirubin	50-59	albumin	Macaca mulatta	196-199
6657916-7	1983	BR radical ions in alkaline solution did not react with tryptophan (TrpH), but the semioxidized TrpH radical oxidized BR with k = 4.3 X 10(8) dm3 mole-1 sec-1.	Bilirubin	0-2	tryptophan hydroxylase 1	Homo sapiens	96-100
6382275-6	1984	Because of the frequent isolation of E coli in calcium bilirubinate stone cases, beta-glucuronidase from E coli has been thought to be responsible for the formation of calcium bilirubinate stones by effecting hydrolysis of bilirubin glucuronide to free bilirubin, which is insoluble in water.	Bilirubin	47-67	glucuronidase beta	Homo sapiens	81-99
6382275-6	1984	Because of the frequent isolation of E coli in calcium bilirubinate stone cases, beta-glucuronidase from E coli has been thought to be responsible for the formation of calcium bilirubinate stones by effecting hydrolysis of bilirubin glucuronide to free bilirubin, which is insoluble in water.	Bilirubin	168-188	glucuronidase beta	Homo sapiens	81-99
6382275-6	1984	Because of the frequent isolation of E coli in calcium bilirubinate stone cases, beta-glucuronidase from E coli has been thought to be responsible for the formation of calcium bilirubinate stones by effecting hydrolysis of bilirubin glucuronide to free bilirubin, which is insoluble in water.	Bilirubin	55-64	glucuronidase beta	Homo sapiens	81-99
6382275-6	1984	Because of the frequent isolation of E coli in calcium bilirubinate stone cases, beta-glucuronidase from E coli has been thought to be responsible for the formation of calcium bilirubinate stones by effecting hydrolysis of bilirubin glucuronide to free bilirubin, which is insoluble in water.	Bilirubin	176-185	glucuronidase beta	Homo sapiens	81-99
6694518-0	1984	Inhibition of uroporphyrinogen I synthase activity and depression of microsomal heme and cytochrome P-450 in rat liver by bilirubin.	Bilirubin	122-131	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	89-105
6694518-1	1984	Purified rat hepatic uroporphyrinogen (UROgen) I synthase (URO-S) was inhibited by bilirubin or the ditaurine derivative.	Bilirubin	83-92	uroporphyrinogen III synthase	Rattus norvegicus	59-64
6657916-7	1983	BR radical ions in alkaline solution did not react with tryptophan (TrpH), but the semioxidized TrpH radical oxidized BR with k = 4.3 X 10(8) dm3 mole-1 sec-1.	Bilirubin	0-2	secretory blood group 1, pseudogene	Homo sapiens	153-158
6657916-9	1983	When BR was complexed with the protein the transformation rate was reduced to 1.6 X 10(3) sec-1.	Bilirubin	5-7	secretory blood group 1, pseudogene	Homo sapiens	90-95
6618107-6	1983	Dissolved mucin in supernatant bile increased from 7.46 +/- 1.19 mg/ml (day 0) to 27.36 +/- 3.05 mg/ml (day 3) (p less than 0.001), while bilirubin concentration decreased from 127 +/- 12 mg/dl (day 0) to 71 +/- 16 mg/dl (day 3) (p less than 0.001).	Bilirubin	138-147	mucin	Canis lupus familiaris	10-15
6618107-8	1983	Mucin-bilirubin complexes formed and remained suspended as sludge initially.	Bilirubin	6-15	mucin	Canis lupus familiaris	0-5
6873615-0	1983	Bovine gallbladder mucin binds bilirubin in vitro.	Bilirubin	31-40	mucin 1, cell surface associated	Bos taurus	19-24
6883685-0	1983	Abnormally high values for direct bilirubin in serum as measured with the Technicon SMAC.	Bilirubin	34-43	diablo IAP-binding mitochondrial protein	Homo sapiens	84-88
6140748-3	1983	Correlations of SLI to se-bilirubin and p-coagulation factors 2, 7 and 10 were significant, P less than 0.001 and P less than 0.01, respectively, whereas no correlation to plasma insulin could be elicited.	Bilirubin	26-35	SHC adaptor protein 2	Homo sapiens	16-19
6616824-7	1983	There was negligible interference from hemoglobin and dextran as well as several common substances that bind to albumin--bilirubin and salicylate.	Bilirubin	121-130	albumin	Homo sapiens	112-119
6873615-1	1983	Gallbladder mucin glycoprotein and bilirubin are frequently identified at the center of human cholesterol gallstones, suggesting that mucin-bilirubin complexes might function as nucleating agents for cholesterol gallstones.	Bilirubin	35-44	LOC100508689	Homo sapiens	134-139
6873615-1	1983	Gallbladder mucin glycoprotein and bilirubin are frequently identified at the center of human cholesterol gallstones, suggesting that mucin-bilirubin complexes might function as nucleating agents for cholesterol gallstones.	Bilirubin	140-149	LOC100508689	Homo sapiens	12-17
6873615-1	1983	Gallbladder mucin glycoprotein and bilirubin are frequently identified at the center of human cholesterol gallstones, suggesting that mucin-bilirubin complexes might function as nucleating agents for cholesterol gallstones.	Bilirubin	140-149	LOC100508689	Homo sapiens	134-139
6873615-2	1983	This study was undertaken to determine if bovine gallbladder mucin was capable of binding bilirubin in vitro.	Bilirubin	90-99	mucin 1, cell surface associated	Bos taurus	61-66
6873615-5	1983	Alteration of the polymeric structure of mucin with mercaptoethanol caused loss of its ability to bind bilirubin, suggesting that the native polymeric configuration is required.	Bilirubin	103-112	mucin 1, cell surface associated	Bos taurus	41-46
6873615-6	1983	These results indicate that mucin can bind bilirubin in vitro, and might explain their occurrence in the nucleus of human cholesterol stones.	Bilirubin	43-52	LOC100508689	Homo sapiens	28-33
6308060-7	1983	Uptake of 10 nmol of [3H]bilirubin was 67.5 +/- 3.7% of the dose when injected with 125I-albumin, 67.4 +/- 6.5% when injected with 125I-ligandin, and 74.9 +/- 2.4% when injected with [14C]sucrose (P greater than 0.1).	Bilirubin	25-34	glutathione S-transferase alpha 2	Rattus norvegicus	136-144
6308060-13	1983	These results suggest that the hepatic bilirubin uptake mechanism is one of high affinity which can extract bilirubin from circulating carriers such as albumin, ligandin, or fluorocarbon.	Bilirubin	39-48	glutathione S-transferase alpha 2	Rattus norvegicus	161-169
6308060-13	1983	These results suggest that the hepatic bilirubin uptake mechanism is one of high affinity which can extract bilirubin from circulating carriers such as albumin, ligandin, or fluorocarbon.	Bilirubin	108-117	glutathione S-transferase alpha 2	Rattus norvegicus	161-169
6409115-3	1983	The activity of P-450 was increased by approximately 30% and that of UDPGT by 15-24 and 45-66%, respectively, employing bilirubin and p-nitrophenol as the acceptor substrate.	Bilirubin	120-129	UDP glucuronosyltransferase family 1 member A5	Rattus norvegicus	69-74
6871245-9	1983	Microsomal oxidation of bilirubin and glucuronides also occurred in untreated and digitonin-treated microsomes and was stimulated by NADPH and by the cytochrome P-450 inhibitor, metyrapone.	Bilirubin	24-33	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	150-166
6190841-6	1983	A rabbit antibody to the BSP-binding protein gave a line of identity with both the BSP- and bilirubin-binding antigens, and inhibited the binding of [14C]bilirubin and [35S]BSP, but not [14C]oleate or [14C]taurocholate, to rat liver plasma membranes.	Bilirubin	92-101	integrin-binding sialoprotein	Rattus norvegicus	25-28
6190841-6	1983	A rabbit antibody to the BSP-binding protein gave a line of identity with both the BSP- and bilirubin-binding antigens, and inhibited the binding of [14C]bilirubin and [35S]BSP, but not [14C]oleate or [14C]taurocholate, to rat liver plasma membranes.	Bilirubin	154-163	integrin-binding sialoprotein	Rattus norvegicus	25-28
6190841-6	1983	A rabbit antibody to the BSP-binding protein gave a line of identity with both the BSP- and bilirubin-binding antigens, and inhibited the binding of [14C]bilirubin and [35S]BSP, but not [14C]oleate or [14C]taurocholate, to rat liver plasma membranes.	Bilirubin	154-163	integrin-binding sialoprotein	Rattus norvegicus	83-86
6190841-6	1983	A rabbit antibody to the BSP-binding protein gave a line of identity with both the BSP- and bilirubin-binding antigens, and inhibited the binding of [14C]bilirubin and [35S]BSP, but not [14C]oleate or [14C]taurocholate, to rat liver plasma membranes.	Bilirubin	154-163	integrin-binding sialoprotein	Rattus norvegicus	83-86
6407073-1	1983	The administration of tri-iodothyronine (T3) to female Sprague-Dawley (SD) rats lowered the basal activity of uridine diphosphoglucuronate glucuronosyl transferase (UDPGT:EC 2.4.1.17) for bilirubin (Bili) by 75 percent, but dramatically increased the level of UDP-glucuronosyl transferase for p-nitrophenol (UDPGT-PNP) by more than 100 percent.	Bilirubin	188-197	UDP glucuronosyltransferase family 2 member B15	Rattus norvegicus	165-170
6851111-0	1983	Bilirubin interferes in the aca determination of Mg2+ in serum.	Bilirubin	0-9	mucin 7, secreted	Homo sapiens	49-52
6406101-1	1983	The activity of bilirubin-UDP-glucuronyl transferase (UDPGT) in rat liver microsomes was assayed in standardized incubation mixtures employing two different procedures to quantitate formation of conjugated bilirubin: solvent extraction and diazotization with sulfanilic acid, or selective coupling with diazotized ethyl anthranilate at pH 2.7.	Bilirubin	16-25	UDP glucuronosyltransferase family 1 member A5	Rattus norvegicus	54-59
6133900-0	1983	Maximal hepatic bilirubin transport in the rat during somatostatin-induced cholestasis and taurocholate-choleresis.	Bilirubin	16-25	somatostatin	Rattus norvegicus	54-66
6133900-2	1983	The administration of somatostatin (2 micrograms/hr/100 gm body weight) produced a reversible decrease of bile flow and bile acid excretion while bilirubin output was unchanged.	Bilirubin	146-155	somatostatin	Rattus norvegicus	22-34
6133900-3	1983	After discontinuation of somatostatin, a slight increase in the output of bilirubin conjugates was observed with the rapid recovery of bile flow.	Bilirubin	74-83	somatostatin	Rattus norvegicus	25-37
6840080-2	1983	Results of experiments based upon circular dichroic spectra suggest that configurationally (Z leads to E) isomerized bilirubin (photobilirubin) binds to human serum albumin at the primary bilirubin binding site with an affinity only 2-3 times lower than that of bilirubin.	Bilirubin	117-126	albumin	Homo sapiens	159-172
6840080-2	1983	Results of experiments based upon circular dichroic spectra suggest that configurationally (Z leads to E) isomerized bilirubin (photobilirubin) binds to human serum albumin at the primary bilirubin binding site with an affinity only 2-3 times lower than that of bilirubin.	Bilirubin	133-142	albumin	Homo sapiens	159-172
6840080-2	1983	Results of experiments based upon circular dichroic spectra suggest that configurationally (Z leads to E) isomerized bilirubin (photobilirubin) binds to human serum albumin at the primary bilirubin binding site with an affinity only 2-3 times lower than that of bilirubin.	Bilirubin	133-142	albumin	Homo sapiens	159-172
6407073-1	1983	The administration of tri-iodothyronine (T3) to female Sprague-Dawley (SD) rats lowered the basal activity of uridine diphosphoglucuronate glucuronosyl transferase (UDPGT:EC 2.4.1.17) for bilirubin (Bili) by 75 percent, but dramatically increased the level of UDP-glucuronosyl transferase for p-nitrophenol (UDPGT-PNP) by more than 100 percent.	Bilirubin	199-203	UDP glucuronosyltransferase family 2 member B15	Rattus norvegicus	165-170
6407073-3	1983	T3 administered to C57BL/6J, DBA/2J, Swiss-Webster (SW) and CD-1 mice significantly increased hepatic UDPGT-Bili by 28, 69, 79 and 94%, respectively.	Bilirubin	108-112	UDP glucuronosyltransferase 1 family, polypeptide A6A	Mus musculus	102-107
6407073-4	1983	The increase of UDPGT-Bili in the selected strains was observed to be inversely and linearly proportional to the basal level of enzyme measured in each strain (r = -0.99215; p less than 0.001).	Bilirubin	22-26	UDP glucuronosyltransferase family 2 member B15	Rattus norvegicus	16-21
6825785-1	1983	A discriminant analysis was performed on a set of maternal and neonatal variables to predict at birth the serum bilirubin levels during the neonatal period in infants incompatible with their mothers in the ABO system.	Bilirubin	112-121	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	206-209
6131667-6	1982	The mammary-gland glutathione S-transferase exhibits characteristics quite similar to those described for the liver and kidney enzymes with respect to substrates, isoenzymes, molecular weight and probenecid and bilirubin inhibition.	Bilirubin	211-220	hematopoietic prostaglandin D synthase	Rattus norvegicus	18-43
6855381-11	1983	beta-Glucuronidase producing bacteria increase the amount of beta-glucuronidase in the bile thus leading to calcium bilirubinate precipitation and gallstone formation by deconjugation of bilirubindiglucuronide.	Bilirubin	108-128	glucuronidase beta	Canis lupus familiaris	0-18
6855381-11	1983	beta-Glucuronidase producing bacteria increase the amount of beta-glucuronidase in the bile thus leading to calcium bilirubinate precipitation and gallstone formation by deconjugation of bilirubindiglucuronide.	Bilirubin	108-128	glucuronidase beta	Canis lupus familiaris	61-79
6130905-13	1982	The results support the hypothesis that PCN induces a form of UDP-GT that preferentially conjugates the group-3 acceptors, bilirubin and DIG.	Bilirubin	123-132	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	62-68
7172961-1	1982	In the homozygous jaundiced Gunn rat, bilirubin catabolism is augmented by intense illumination (phototherapy) and by induction of microsomal cytochrome P448.	Bilirubin	38-47	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	142-157
6983877-4	1982	Fasting plasma concentrations of LDL-C were most strongly and consistently associated in each gender with age, the Quetelet Index of body mass, the number of cigarettes smoked per day, systolic blood pressure, and the levels of plasma glucose and uric acid (all positive associations); and with height and bilirubin levels (both negative associations).	Bilirubin	306-315	component of oligomeric golgi complex 2	Homo sapiens	33-38
7184813-0	1982	[Effect of oxytocin during labor on the bilirubin level of umbilical cord blood and the blood of newborn infants].	Bilirubin	40-49	oxytocin/neurophysin I prepropeptide	Homo sapiens	11-19
6288860-0	1982	Cerebellar hypoplasia in Gunn rats: effects of bilirubin on the maturation of glutamate decarboxylase, Na,K-ATPase, 2",3"-cyclic nucleotide 3"-phosphohydrolase, acetylcholine and aryl esterase, succinate and lactate dehydrogenase, and arylsulfatase activities.	Bilirubin	47-56	glutamate-ammonia ligase	Rattus norvegicus	78-101
7095558-5	1982	The fraction of total serum bilirubin represented by C-8 monoconjugates, C-12 monoconjugates, diconjugates, and total ester conjugates was higher in patients with biliary obstruction than in those with parenchymal liver disease, but extensive overlap between groups prevented determination of these conjugated species from being diagnostically useful.	Bilirubin	28-37	homeobox C8	Homo sapiens	53-56
6293205-0	1982	[Serum haptoglobin and 5"-nucleotidase levels in patients with acute viral hepatitis with low and high bilirubin levels].	Bilirubin	103-112	haptoglobin	Homo sapiens	7-18
6817411-7	1982	Beta-glucuronidase will split the conjugated bilirubin in bile into glucuronic acid and unconjugated bilirubin, which in turn combine with calcium to form insoluble calcium bilirubinate.	Bilirubin	45-54	glucuronidase beta	Homo sapiens	0-18
6817411-7	1982	Beta-glucuronidase will split the conjugated bilirubin in bile into glucuronic acid and unconjugated bilirubin, which in turn combine with calcium to form insoluble calcium bilirubinate.	Bilirubin	101-110	glucuronidase beta	Homo sapiens	0-18
6817411-7	1982	Beta-glucuronidase will split the conjugated bilirubin in bile into glucuronic acid and unconjugated bilirubin, which in turn combine with calcium to form insoluble calcium bilirubinate.	Bilirubin	165-185	glucuronidase beta	Homo sapiens	0-18
6806274-3	1982	UDP-glucuronosyltransferase activities toward estrone, bilirubin, 4-nitrophenol, and morphine did not co-purify with the activity toward chenodeoxycholic acid and testosterone and were not detectable in the pure enzyme in the presence or absence of phospholipids.	Bilirubin	55-64	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	0-27
6281914-7	1982	In many clinical situations, even in patients with high bilirubin levels, the 99m-Fc-labeled IDAs offer far superior clinical information over the alternative diagnostic imaging modalities.	Bilirubin	56-65	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	93-97
7089071-0	1982	Quantum yield and equilibrium position of the configurational photoisomerization of bilirubin bound to human serum albumin.	Bilirubin	84-93	albumin	Homo sapiens	109-122
6276397-0	1982	Human serum albumin: an allosteric domain model for bilirubin binding specificity.	Bilirubin	52-61	albumin	Homo sapiens	6-19
7161688-8	1982	Analysis of our results unexpectedly indicated that oxytocin induction was generally associated with an attenuation of bilirubin levels after both vacuum extraction and spontaneous delivery.	Bilirubin	119-128	oxytocin/neurophysin I prepropeptide	Homo sapiens	52-60
7074113-0	1982	The kinetics of the reaction between bovine serum albumin and bilirubin.	Bilirubin	62-71	albumin	Homo sapiens	44-57
7074113-2	1982	The kinetics of the reaction between bilirubin and bovine serum albumin have been re-investigated at 20 degrees C. The results of previous authors concerning both human and bovine serum albumin were largely confirmed, namely the existence of two first-order configurational changes after a primary complex is formed in a fast, bimolecular step.	Bilirubin	37-46	albumin	Homo sapiens	58-71
7074113-2	1982	The kinetics of the reaction between bilirubin and bovine serum albumin have been re-investigated at 20 degrees C. The results of previous authors concerning both human and bovine serum albumin were largely confirmed, namely the existence of two first-order configurational changes after a primary complex is formed in a fast, bimolecular step.	Bilirubin	37-46	albumin	Homo sapiens	180-193
7340827-10	1981	Binding studies revealed that PLAT Y(1) and PLAT Y(2) fractions had much lower affinities for sulphobromophthalein and bilirubin than rat Y-fraction.	Bilirubin	119-128	plasminogen activator, tissue type	Rattus norvegicus	30-34
7040592-0	1982	[Effects of haemolysis, urea and bilirubin on the precision of digoxin and insulin radioimmunoassays (author"s transl)].	Bilirubin	33-42	insulin	Homo sapiens	75-82
7036932-4	1981	Results show that mean plasma bilirubin levels are significantly lower in the treated group as compared with the control group, from the 16th hour of treatment, if there is no ABO incompatibility.	Bilirubin	30-39	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	176-179
7327268-0	1981	Purification and bilirubin binding properties of glutathione S-transferase from human placenta.	Bilirubin	17-26	glutathione S-transferase kappa 1	Homo sapiens	49-74
7340827-10	1981	Binding studies revealed that PLAT Y(1) and PLAT Y(2) fractions had much lower affinities for sulphobromophthalein and bilirubin than rat Y-fraction.	Bilirubin	119-128	plasminogen activator, tissue type	Rattus norvegicus	44-48
7314225-3	1981	At levels of serum bilirubin below 301 mumol/l, ABO incompatible combinations occurred as frequently as ABO compatible combinations.	Bilirubin	19-28	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	48-51
7322267-3	1981	In this study, the hem-oxygenase which converts oxyHb to bilirubin was analyzed and the increase of hem-oxygenase in the CSF after SAH was reconfirmed.	Bilirubin	57-66	colony stimulating factor 2	Homo sapiens	121-124
7314225-4	1981	However, at serum bilirubins above 301 mumol/l, ABO incompatibility was a major cause of jaundice in almost 58 per cent of infants.	Bilirubin	18-28	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	48-51
7313301-1	1981	The effect produced by unconjugated bilirubin (UB) on p-aminohippuric acid (PAH) translocation from plasma to the urine, was analyzed by using an isolated rat kidney preparation applying the multiple indicator dilution technique.	Bilirubin	36-45	phenylalanine hydroxylase	Rattus norvegicus	76-79
7272326-1	1981	The fast step in the conformational change of human serum albumin from the alkaline to the neutral form of the albumin-bilirubin complex is studied by various pH jump experiments in a stopped-flow apparatus.	Bilirubin	119-128	albumin	Homo sapiens	52-65
6269161-0	1981	[Inhibition of the cholestatic enzyme 5"-nucleotidase by high levels of bilirubin].	Bilirubin	72-81	5'-nucleotidase ecto	Homo sapiens	38-53
7284009-0	1981	Circularly polarised luminescence of bilirubin bound to human serum albumin.	Bilirubin	37-46	albumin	Homo sapiens	62-75
7026403-3	1981	Circular dichroism spectra of Z protein-bilirubin (unconjugated and diglucuronide) complexes revealed two ellipticity extrema, a negative peak at 460 nm, and a positive peak at 410 nm.	Bilirubin	40-49	transmembrane BAX inhibitor motif containing 4	Homo sapiens	30-39
7332128-7	1981	Total bilirubin was significantly (P less than or equal to 0.05) increased from days 1 to 4 (pony) or days 5 to 8 (dog) after the CCl4 dose, but subsequently returned to or decreased below base-line values.	Bilirubin	6-15	C-C motif chemokine 4	Canis lupus familiaris	130-134
7226535-0	1981	beta-Glucuronidase-resistant bilirubin glucuronide isomers in cholestatic liver disease--determination of bilirubin metabolites in serum by means of high-pressure liquid chromatography.	Bilirubin	29-38	glucuronidase beta	Homo sapiens	0-18
7238264-5	1981	Although the degree of PSE was similar in both groups, those PSE patients with the higher prolactin values had significantly greater derangement of serum albumin, bilirubin, prothrombin time, and also had a higher mortality (100%).	Bilirubin	163-172	prolactin	Homo sapiens	90-99
6941267-0	1981	Picosecond primary photoprocesses of bilirubin bound to human serum albumin.	Bilirubin	37-46	albumin	Homo sapiens	62-75
6941267-1	1981	We measure the fluorescence quantum yield of bilirubin bound to its highest-affinity site on human serum albumin to increase from about 0.001 near room temperature to 0.5 at 77 K. The quantum yield for configurational (Z leads to E) photoisomerization about the meso double bonds concomitantly decreases from about 0.22 to less than 0.01 over the same temperature range in reciprocal relationship to the fluorescence yield.	Bilirubin	45-54	albumin	Homo sapiens	99-112
7226535-0	1981	beta-Glucuronidase-resistant bilirubin glucuronide isomers in cholestatic liver disease--determination of bilirubin metabolites in serum by means of high-pressure liquid chromatography.	Bilirubin	106-115	glucuronidase beta	Homo sapiens	0-18
7226535-3	1981	Bilirubin glucuronides in normal bile are beta-glycosidic 1-O-acyl conjugates which are completely hydrolyzed on incubation with beta-glucuronidase.	Bilirubin	0-9	glucuronidase beta	Homo sapiens	129-147
7457612-10	1981	Thus, BSP is hydrocholeretic but decreases phospholipid, cholesterol, and bilirubin secretion in both humans and dogs.	Bilirubin	74-83	integrin binding sialoprotein	Homo sapiens	6-9
7418142-6	1980	Subjects with high serum bilirubin or serum aspartate aminotransferase (AST, SGOT) values have higher HDL cholesterol levels that are statistically significant in men 20-69 years and women 20-44 years (bilirubin) and men 45-69 years and women 45-69 years (AST).	Bilirubin	25-34	solute carrier family 17 member 5	Homo sapiens	256-259
7217254-2	1981	Reversed-phase chromatography on short-chain alkylsilica (C2) or octadecylsilica (C18) with acetonitrile--dimethylsulphoxide--water as eluent is used for the separation of bilirubin.	Bilirubin	172-181	Bardet-Biedl syndrome 9	Homo sapiens	82-85
6121372-8	1981	It seems that SASP preferentially is bound to other sites on albumin than to the high-affinity binding site for bilirubin.	Bilirubin	112-121	aspartic peptidase retroviral like 1	Homo sapiens	14-18
7418142-6	1980	Subjects with high serum bilirubin or serum aspartate aminotransferase (AST, SGOT) values have higher HDL cholesterol levels that are statistically significant in men 20-69 years and women 20-44 years (bilirubin) and men 45-69 years and women 45-69 years (AST).	Bilirubin	202-211	solute carrier family 17 member 5	Homo sapiens	44-70
7418142-6	1980	Subjects with high serum bilirubin or serum aspartate aminotransferase (AST, SGOT) values have higher HDL cholesterol levels that are statistically significant in men 20-69 years and women 20-44 years (bilirubin) and men 45-69 years and women 45-69 years (AST).	Bilirubin	202-211	solute carrier family 17 member 5	Homo sapiens	72-75
7418142-6	1980	Subjects with high serum bilirubin or serum aspartate aminotransferase (AST, SGOT) values have higher HDL cholesterol levels that are statistically significant in men 20-69 years and women 20-44 years (bilirubin) and men 45-69 years and women 45-69 years (AST).	Bilirubin	202-211	solute carrier family 17 member 5	Homo sapiens	256-259
6251985-3	1980	Glutathione S-transferase activity was inhibited by bilirubin, but this inhibition was counteracted by the presence of a low concentration of albumin.	Bilirubin	52-61	glutathione S-transferase kappa 1	Homo sapiens	0-25
7256934-5	1980	It is shown that bilirubin displaces steroids from the sites of their fixation in albumin.	Bilirubin	17-26	albumin	Homo sapiens	82-89
7208154-0	1980	Phototherapy-induced covalent binding of bilirubin to serum albumin.	Bilirubin	41-50	albumin	Bos taurus	54-67
7208154-1	1980	Bilirubin displays a detectable fluorescence emission only when it is complexed with serum albumin, whereas free bilirubin has a very low fluorescence yield.	Bilirubin	0-9	albumin	Bos taurus	85-98
7208154-2	1980	Actually, nearly complete disappearance of bilirubin emission was obtained when the unirradiated human serum albumin-bilirubin complex was precipitated with acetone to extract the pigment; complete removal of protein-bound bilirubin (as monitored by fluorescence spectroscopy) was achieved by repeating the acetone extraction after incubation of the complex in the phosphate buffer, pH 7.4, containing 7 M guanidinium chloride; the latter compound causes on extensive unfolding of protein molecules.	Bilirubin	43-52	albumin	Bos taurus	103-116
7208154-2	1980	Actually, nearly complete disappearance of bilirubin emission was obtained when the unirradiated human serum albumin-bilirubin complex was precipitated with acetone to extract the pigment; complete removal of protein-bound bilirubin (as monitored by fluorescence spectroscopy) was achieved by repeating the acetone extraction after incubation of the complex in the phosphate buffer, pH 7.4, containing 7 M guanidinium chloride; the latter compound causes on extensive unfolding of protein molecules.	Bilirubin	117-126	albumin	Bos taurus	103-116
7208154-2	1980	Actually, nearly complete disappearance of bilirubin emission was obtained when the unirradiated human serum albumin-bilirubin complex was precipitated with acetone to extract the pigment; complete removal of protein-bound bilirubin (as monitored by fluorescence spectroscopy) was achieved by repeating the acetone extraction after incubation of the complex in the phosphate buffer, pH 7.4, containing 7 M guanidinium chloride; the latter compound causes on extensive unfolding of protein molecules.	Bilirubin	117-126	albumin	Bos taurus	103-116
7208154-4	1980	This finding clearly shows that bilirubin and/or some photoproduct underwent in part a photoinduced covalent binding with human serum albumin.	Bilirubin	32-41	albumin	Bos taurus	128-141
7372607-0	1980	Bilirubin binding to human liver ligandin (glutathione S-transferase).	Bilirubin	0-9	glutathione S-transferase kappa 1	Homo sapiens	43-68
6246298-4	1980	Cholestasis was seen in histologic sections of tissue from 8 of 10 patients, and elevated bilirubin was seen in 7 of 10 patients with hepatic metastases and CEA levels greater than 1,000 ng/ml In contrast, histologically observed cholestasis and elevated bilirubin were seen in only 1 of 8 patients with CEA less than 500 ng/ml.	Bilirubin	90-99	CEA cell adhesion molecule 3	Homo sapiens	157-160
6246298-4	1980	Cholestasis was seen in histologic sections of tissue from 8 of 10 patients, and elevated bilirubin was seen in 7 of 10 patients with hepatic metastases and CEA levels greater than 1,000 ng/ml In contrast, histologically observed cholestasis and elevated bilirubin were seen in only 1 of 8 patients with CEA less than 500 ng/ml.	Bilirubin	90-99	CEA cell adhesion molecule 3	Homo sapiens	304-307
6769435-0	1980	The effect of premature and delayed birth on the development of UDP-glucuronosyltransferase activities towards bilirubin, morphine and testosterone in the rat.	Bilirubin	111-120	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	64-91
6154708-0	1980	alpha-fetoprotein binding specificity for arachidonate, bilirubin, docosahexaenoate, and palmitate.	Bilirubin	56-65	alpha fetoprotein	Bos taurus	0-17
6154708-7	1980	These results indicate that polyunsaturated essential fatty acids and bilirubin share a high affinity binding site on AFP.	Bilirubin	70-79	alpha fetoprotein	Bos taurus	118-121
6154708-8	1980	We propose that the function of this anionic ligand binding site on AFP is for the transport of bilirubin and polyunsaturated fatty acids in fetal serum, as well as for the cross-placental transfer of this metabolite and of essential fatty acids.	Bilirubin	96-105	alpha fetoprotein	Bos taurus	68-71
6769435-1	1980	In the rat, UDP-glucuronosyltransferase activities towards bilirubin, morphine and testosterone increase markedly after normal or premature birth.	Bilirubin	59-68	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	12-39
6766134-5	1980	Rat testicular ligandin is immunologically similar to liver ligandin, and has identical glutathione-S-transferase activity, but lacks the capacity for high affinity binding of bilirubin and sulfobromophthalein.	Bilirubin	176-185	glutathione S-transferase alpha 2	Rattus norvegicus	15-23
6766134-7	1980	Sulfobromophthalein and bilirubin biphasically inhibit the glutathione-S-transferase activity of liver ligandin: initial high affinity inhibition is followed by reduced inhibition.	Bilirubin	24-33	glutathione S-transferase alpha 2	Rattus norvegicus	103-111
7356894-2	1980	The effect of ampicillin, cloxacillin, flucloxacillin and sulphafurazole on bilirubin on bilirubin binding by pooled human umbilical cord serum and bovine serum albumin was studied in vitro using Sephadex gel filtration.	Bilirubin	89-98	albumin	Homo sapiens	155-168
7274562-3	1980	Bilirubin binding was chosen as a method to describe functional quality of albumin preparations.	Bilirubin	0-9	albumin	Homo sapiens	75-82
90526-0	1979	Binding of bilirubin by bovine and human alpha-fetoprotein.	Bilirubin	11-20	alpha fetoprotein	Homo sapiens	41-58
91613-2	1979	The binding of bilirubin and the polyene fatty acids cis-parinaric acid and cis-eleostearic acid to human alpha-fetoprotein was studied using fluorescence quenching and fluorescence enhancement techniques.	Bilirubin	15-24	alpha fetoprotein	Homo sapiens	106-123
91613-3	1979	alpha-Fetoprotein has three fatty acid binding sites of decreasing affinity (association constants 2.1 x 10(7) M-1 9.1 X 10(5) M-1, and 1.4 x 10(5) M-1) and one relatively strong and one relatively weak bilirubin binding site (association constants 1.1 x 10(7) M-1 and 1.8 x 10(5) M-1).	Bilirubin	203-212	alpha fetoprotein	Homo sapiens	0-17
89900-0	1979	alpha-Fetoprotein as a carrier protein in plasma and its bilirubin-binding ability.	Bilirubin	57-66	alpha fetoprotein	Homo sapiens	0-17
89900-2	1979	The difference spectrum observed as a result of the specific binding of bilirubin to alpha-fetoprotein had a maximum at 482 nm, and this pattern was quite similar to that observed for serum albumin.	Bilirubin	72-81	alpha fetoprotein	Homo sapiens	85-102
89900-3	1979	The result obtained by the difference spectrum method showed that 1 mol of each alpha-fetoprotein bound 1 mol of bilirubin at pH 8.3 and that the dissociation constants of the complexes of bilirubin with fetal alpha-fetoprotein and hepatoma-derived alpha-fetoprotein were 2.6 x 10(-7) and 5.0 x 10(-7) M, respectively.	Bilirubin	113-122	alpha fetoprotein	Homo sapiens	80-97
89900-3	1979	The result obtained by the difference spectrum method showed that 1 mol of each alpha-fetoprotein bound 1 mol of bilirubin at pH 8.3 and that the dissociation constants of the complexes of bilirubin with fetal alpha-fetoprotein and hepatoma-derived alpha-fetoprotein were 2.6 x 10(-7) and 5.0 x 10(-7) M, respectively.	Bilirubin	113-122	alpha fetoprotein	Homo sapiens	210-227
89900-3	1979	The result obtained by the difference spectrum method showed that 1 mol of each alpha-fetoprotein bound 1 mol of bilirubin at pH 8.3 and that the dissociation constants of the complexes of bilirubin with fetal alpha-fetoprotein and hepatoma-derived alpha-fetoprotein were 2.6 x 10(-7) and 5.0 x 10(-7) M, respectively.	Bilirubin	113-122	alpha fetoprotein	Homo sapiens	210-227
89900-3	1979	The result obtained by the difference spectrum method showed that 1 mol of each alpha-fetoprotein bound 1 mol of bilirubin at pH 8.3 and that the dissociation constants of the complexes of bilirubin with fetal alpha-fetoprotein and hepatoma-derived alpha-fetoprotein were 2.6 x 10(-7) and 5.0 x 10(-7) M, respectively.	Bilirubin	189-198	alpha fetoprotein	Homo sapiens	80-97
89900-3	1979	The result obtained by the difference spectrum method showed that 1 mol of each alpha-fetoprotein bound 1 mol of bilirubin at pH 8.3 and that the dissociation constants of the complexes of bilirubin with fetal alpha-fetoprotein and hepatoma-derived alpha-fetoprotein were 2.6 x 10(-7) and 5.0 x 10(-7) M, respectively.	Bilirubin	189-198	alpha fetoprotein	Homo sapiens	210-227
89900-3	1979	The result obtained by the difference spectrum method showed that 1 mol of each alpha-fetoprotein bound 1 mol of bilirubin at pH 8.3 and that the dissociation constants of the complexes of bilirubin with fetal alpha-fetoprotein and hepatoma-derived alpha-fetoprotein were 2.6 x 10(-7) and 5.0 x 10(-7) M, respectively.	Bilirubin	189-198	alpha fetoprotein	Homo sapiens	210-227
89900-5	1979	These results indicate that alpha-fetoprotein may function as a carrier protein for bilirubin as has been shown for serum albumin.	Bilirubin	84-93	alpha fetoprotein	Homo sapiens	28-45
455689-1	1979	We describe a method for the bichromatic determination of total bilirubin with a CentrifiChem 400 centrifugal analyzer with the Boehringer DPD kit.	Bilirubin	64-73	dihydropyrimidine dehydrogenase	Homo sapiens	139-142
6169059-7	1980	Serum AFP concentrations in neonates with physiological jaundice, were seldom elevated, and showed a good correlation with serum levels of total bilirubin.	Bilirubin	145-154	alpha fetoprotein	Homo sapiens	6-9
6769180-1	1980	In C57BL/6 mice, aryl hydrocarbon hydroxylase (AHH) increased 1 day after treatment with 3-methylcholanthrene, and induction of UDP-glucuronyl transferases for 3-hydroxybenzo(a)pyrene, p-nitrophenol and bilirubin in the liver microsomes was observed 2 to 5 days later.	Bilirubin	203-212	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	17-45
6769180-1	1980	In C57BL/6 mice, aryl hydrocarbon hydroxylase (AHH) increased 1 day after treatment with 3-methylcholanthrene, and induction of UDP-glucuronyl transferases for 3-hydroxybenzo(a)pyrene, p-nitrophenol and bilirubin in the liver microsomes was observed 2 to 5 days later.	Bilirubin	203-212	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	47-50
518557-0	1979	Photoactivated covalent binding of [3H]bilirubin to human serum albumin.	Bilirubin	39-48	albumin	Homo sapiens	58-71
518557-2	1979	Irradiation of an aqueous solution of [3H]bilirubin IX-alpha in the presence of human serum albumin results in the covalent attachment of the bilirubin to the protein.	Bilirubin	42-51	albumin	Homo sapiens	86-99
518557-2	1979	Irradiation of an aqueous solution of [3H]bilirubin IX-alpha in the presence of human serum albumin results in the covalent attachment of the bilirubin to the protein.	Bilirubin	142-151	albumin	Homo sapiens	86-99
90526-1	1979	alpha-Fetoprotein, a fetal protein associated with certain tumors, was found to bind bilirubin.	Bilirubin	85-94	alpha fetoprotein	Bos taurus	0-17
90526-2	1979	Addition of human or bovine alpha-fetoprotein to bilirubin solutions enhanced the light absorbance of bilirubin and shifted its  maximum.	Bilirubin	49-58	alpha fetoprotein	Bos taurus	28-45
90526-2	1979	Addition of human or bovine alpha-fetoprotein to bilirubin solutions enhanced the light absorbance of bilirubin and shifted its  maximum.	Bilirubin	102-111	alpha fetoprotein	Bos taurus	28-45
90526-4	1979	The spectral changes were used to study the characteristics of the binding of bilirubin by bovine alpha-fetoprotein.	Bilirubin	78-87	alpha fetoprotein	Bos taurus	98-115
90526-7	1979	A difference between the spectral changes brought about by alpha-fetoprotein and albumin allowed comparison of their relative affinities for bilirubin.	Bilirubin	141-150	alpha fetoprotein	Bos taurus	59-76
90526-9	1979	These results show that alpha-fetoprotein from two species binds bilirubin with an affinity somewhat lower than that of albumin.	Bilirubin	65-74	alpha fetoprotein	Bos taurus	24-41
90526-10	1979	Binding of bilirubin by alpha-fetoprotein is in agreement with the recent demonstration of structural homology between alpha-fetoprotein and albumin.	Bilirubin	11-20	alpha fetoprotein	Bos taurus	24-41
90526-10	1979	Binding of bilirubin by alpha-fetoprotein is in agreement with the recent demonstration of structural homology between alpha-fetoprotein and albumin.	Bilirubin	11-20	alpha fetoprotein	Bos taurus	119-136
90526-11	1979	Whether alpha-fetoprotein plays a role in the metabolism of bilirubin or other degradation products of heme remains to be investigated.	Bilirubin	60-69	alpha fetoprotein	Bos taurus	8-25
479557-1	1979	Ligandin (glutathione-s-transferase) and Z protein are soluble hepatocellular proteins that are involved in the transfer of organic ions, including bilirubin and some hormones and carcinogens from the plasma to the liver.	Bilirubin	148-157	transmembrane BAX inhibitor motif containing 4	Homo sapiens	41-50
375751-0	1979	Role of ligandin in transfer of bilirubin from plasma into liver.	Bilirubin	32-41	glutathione S-transferase alpha 2	Rattus norvegicus	8-16
475417-3	1979	The babies born after oxytocin induction of labour attained significantly higher serum bilirubin levels at age 72 +/- 12 hours than the controls.	Bilirubin	87-96	oxytocin/neurophysin I prepropeptide	Homo sapiens	22-30
375751-7	1979	The increased net uptake of tracer bilirubin by the liver of phenobarbital-pretreated animals is due to decreased tracer efflux secondary to the increase in intracellular binding of bilirubin by ligandin.	Bilirubin	35-44	glutathione S-transferase alpha 2	Rattus norvegicus	195-203
375751-7	1979	The increased net uptake of tracer bilirubin by the liver of phenobarbital-pretreated animals is due to decreased tracer efflux secondary to the increase in intracellular binding of bilirubin by ligandin.	Bilirubin	182-191	glutathione S-transferase alpha 2	Rattus norvegicus	195-203
761835-2	1979	During an intravenous infusion of BPP at a dose which produced plasma levels similar to those seen after meals in healthy young adults the volume and bicarbonate content of duodenal juice was reduced by 25% (p less than 0.05) and 24% (p less than 0.05) respectively, while protein and bilirubin concentrations were more markedly reduced by 68% (p less than 0.0005) and 67% (p less than 0.0005) respectively.	Bilirubin	285-294	sushi repeat containing protein X-linked 2	Homo sapiens	34-37
427052-1	1979	A prospective study in 180 mothers and babies examined the effects of oxytocin in induced labour on plasma bilirubin levels in cord blood, as well as on the incidence of neonatal jaundice.	Bilirubin	107-116	oxytocin/neurophysin I prepropeptide	Homo sapiens	70-78
427052-2	1979	Raised plasma bilirubin levels in cord blood, probably enhanced by breakdown of fetal red cells, appeared to be a dose dependent effect of oxytocin.	Bilirubin	14-23	oxytocin/neurophysin I prepropeptide	Homo sapiens	139-147
569526-0	1978	Value of measuring cord blood bilirubin concentration in ABO incompatibility.	Bilirubin	30-39	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	57-60
659407-2	1978	Physical methods and chemical modifications were used to discriminate between the bilirubin-binding capacity and glutathione-S-transferase activity of ligandin which was purified from rat liver.	Bilirubin	82-91	glutathione S-transferase alpha 2	Rattus norvegicus	151-159
710304-8	1978	There was a significant correlation between the titre after one year and maximal GPT and bilirubin levels in the acute phase of the illness.	Bilirubin	89-98	glutamic--pyruvic transaminase	Homo sapiens	81-84
524626-0	1979	Use of an AR-1 resin column to reduce bilirubin-level in modified ascitic fluid.	Bilirubin	38-47	transcription factor 20	Homo sapiens	10-14
524626-2	1979	In such cases, a newly developed synthetic resin, AR-1, has been successfully employed to reduce excess bilirubin from the ascitic fluid.	Bilirubin	104-113	transcription factor 20	Homo sapiens	50-54
34912-0	1978	[Isoelectric fractions of healthy human serum albumin and their ability to bind bilirubin].	Bilirubin	80-89	albumin	Homo sapiens	46-53
677161-3	1978	While the Km value of serum AST was not affected in myocardial infarction, it was increased in infectious hepatitis when the total serum bilirubin was higher than 13 mg/dl.	Bilirubin	137-146	solute carrier family 17 member 5	Homo sapiens	28-31
659407-5	1978	Cross-linked as well as reduced and alkylated ligandin lost high affinity bilirubin-binding capacity, but retained glutathione-S-transferase activity, bilirubin binding at a secondary site, and immunological reactivity.	Bilirubin	74-83	glutathione S-transferase alpha 2	Rattus norvegicus	46-54
659407-5	1978	Cross-linked as well as reduced and alkylated ligandin lost high affinity bilirubin-binding capacity, but retained glutathione-S-transferase activity, bilirubin binding at a secondary site, and immunological reactivity.	Bilirubin	151-160	glutathione S-transferase alpha 2	Rattus norvegicus	46-54
659407-6	1978	Succinylation of ligandin abolished catalytic activity and bilirubin binding at high and low affinity sites, but not immunological reactivity.	Bilirubin	59-68	glutathione S-transferase alpha 2	Rattus norvegicus	17-25
659407-8	1978	These results suggest that the high affinity site at which bilirubin is bound to ligandin is independent from the site at which catalytically reactive substrates bind.	Bilirubin	59-68	glutathione S-transferase alpha 2	Rattus norvegicus	81-89
656055-0	1978	Lysine residue 240 of human serum albumin is involved in high-affinity binding of bilirubin.	Bilirubin	82-91	albumin	Homo sapiens	28-41
647211-3	1978	The effect of oxytocin was, however, small, producing a calculated mean increase in peak plasma bilirubin concentration of 8.6 mumol/1 (0.5 mg/100 ml); this excess was independent of sex and less than the effect of the baby being born one week earlier.	Bilirubin	96-105	oxytocin/neurophysin I prepropeptide	Homo sapiens	14-22
656055-7	1978	The results indicate that bilirubin is bound to lysine residue 240 at its high-affinity site on human serum albumin.	Bilirubin	26-35	albumin	Homo sapiens	102-115
620056-0	1978	Interaction of rabbit hemopexin with bilirubin.	Bilirubin	37-46	hemopexin	Oryctolagus cuniculus	22-31
207156-7	1978	Among components of red cells, methemoglobin, methemalbumin, catalase and nicotinamid adenin dinucleotide (NADH) caused constriction of basilar artery in cats, when applied topically, whereas hematin, hemin and bilirubin caused no significant spasm.	Bilirubin	211-220	catalase	Felis catus	61-69
208025-3	1978	A positive correlation was found between Apo A and triglyceride bile acids, log total bilirubin, log SGPT.	Bilirubin	86-95	lipoprotein(a)	Homo sapiens	41-46
620056-2	1978	Hemopexin rapidly forms an equimolar complex with libirubin that has an apparent dissociation constant Kd, of 7.5.10(-7) M. The association alters the absorption band of bilirubin near 150 nm, quenches the fluorescence of tryptophan residues of hemopexin, enhances the fluorescence of bilirubin, and induces strong ellipticity extrema in bilirubin of --60 .	Bilirubin	170-179	hemopexin	Oryctolagus cuniculus	0-9
620056-2	1978	Hemopexin rapidly forms an equimolar complex with libirubin that has an apparent dissociation constant Kd, of 7.5.10(-7) M. The association alters the absorption band of bilirubin near 150 nm, quenches the fluorescence of tryptophan residues of hemopexin, enhances the fluorescence of bilirubin, and induces strong ellipticity extrema in bilirubin of --60 .	Bilirubin	285-294	hemopexin	Oryctolagus cuniculus	0-9
620056-1	1978	The interaction of hemopexin with bilirubin was characterized by spectrophotometric, fluorimetric and circular dichroic techniques.	Bilirubin	34-43	hemopexin	Oryctolagus cuniculus	19-28
620056-2	1978	Hemopexin rapidly forms an equimolar complex with libirubin that has an apparent dissociation constant Kd, of 7.5.10(-7) M. The association alters the absorption band of bilirubin near 150 nm, quenches the fluorescence of tryptophan residues of hemopexin, enhances the fluorescence of bilirubin, and induces strong ellipticity extrema in bilirubin of --60 .	Bilirubin	285-294	hemopexin	Oryctolagus cuniculus	0-9
618909-5	1978	Fluorometric determination of the dissociation constants of purified bilirubin and its mono- and diglucuronides for homogeneous preparations of two human and four rat glutathione S-transferases, including ligandin, revealed avid binding of all three bile pigments to this class of proteins.	Bilirubin	69-78	glutathione S-transferase alpha 2	Rattus norvegicus	205-213
620056-10	1978	In displacement experiments using circular dichroism, heme readily replaced bound bilirubin, indicating that bilirubin and heme are bound at the same site on hemopexin.	Bilirubin	82-91	hemopexin	Oryctolagus cuniculus	158-167
620056-10	1978	In displacement experiments using circular dichroism, heme readily replaced bound bilirubin, indicating that bilirubin and heme are bound at the same site on hemopexin.	Bilirubin	109-118	hemopexin	Oryctolagus cuniculus	158-167
620056-11	1978	Even at molar ratios of hemopexin to albumin of 3 to 1, human serum albumin removes bilirubin from hemopexin.	Bilirubin	84-93	hemopexin	Oryctolagus cuniculus	24-33
620056-11	1978	Even at molar ratios of hemopexin to albumin of 3 to 1, human serum albumin removes bilirubin from hemopexin.	Bilirubin	84-93	hemopexin	Oryctolagus cuniculus	99-108
618909-9	1978	These studies indicate that (a) both bilirubin and its monoglucuronide accumulate within the liver cell as ligands with the glutathione S-transferase; and (b) bilirubin diglucuronide does not significantly accumulate within the general intrahepatocellular pool of protein-bound bile pigments.	Bilirubin	37-46	glutathione S-transferase kappa 1	Homo sapiens	124-149
411659-5	1977	As is the case for human and rat ligandin, porcine ligandin binds bilirubin.	Bilirubin	66-75	glutathione S-transferase alpha 2	Rattus norvegicus	33-41
645287-2	1978	Newborns, whose mothers received more than 5 IU oxytocin had significant higher bilirubin values than the controll group without oxytocin and the cases with oxytocin administration under 5 U. Hyperbilirubinaemie was also present in babies after vacuum extraction and oxytocin infusion.	Bilirubin	80-89	oxytocin/neurophysin I prepropeptide	Homo sapiens	48-56
274712-1	1978	Circular dichroism methods were used to detect bilirubin-ligandin interactions in rat liver cytosol and fractions obtained at various stages during purification of ligandin.	Bilirubin	47-56	glutathione S-transferase alpha 2	Rattus norvegicus	57-65
274712-2	1978	Ligandin retained its capacity to bind bilirubin in the presence of components of liver supernatant, but albumin, which binds bilirubin in serum, lost the capacity to bind bilirubin in liver supernatant.	Bilirubin	39-48	glutathione S-transferase alpha 2	Rattus norvegicus	0-8
411659-5	1977	As is the case for human and rat ligandin, porcine ligandin binds bilirubin.	Bilirubin	66-75	glutathione S-transferase alpha 2	Rattus norvegicus	51-59
18136-8	1977	Bilirubin binds to fragments P44 and P29, and the complexes show similar circular-dichroism spectra to that of the complex between bilirubin and whole albumin.	Bilirubin	0-9	interferon induced protein 44	Homo sapiens	29-32
901814-0	1977	Isolation and identification of a trypsin-resistant fragment of human serum albumin with bilirubin- and drug-binding properties.	Bilirubin	89-98	albumin	Homo sapiens	76-83
901814-5	1977	The fragment mainly retains the secondary and tertiary structure of intact human serum albumin as well as its capacity to bind bilirubin and diazepam.	Bilirubin	127-136	albumin	Homo sapiens	87-94
891104-7	1977	When NEFA concentrations were lowered by insulin, bilirubin concentrations fell.	Bilirubin	50-59	insulin	Homo sapiens	41-48
907411-1	1977	Gel filtration was used to measure drug interaction with protein-bound bilirubin in 0.5 ml samples of Gunn rat serum, human serum and fraction V human serum albumin.	Bilirubin	71-80	albumin	Homo sapiens	151-164
907411-3	1977	The differences between human and rat serum were related to the binding characteristics of sulfadimethoxine whereas the differences between human serum and fraction V human serum albumin were attributed to displacement of bilirubin from albumin to other proteins in serum.	Bilirubin	222-231	albumin	Homo sapiens	173-186
863908-5	1977	The binding properties of the HSA derivatives have been tested with bilirubin, diazepam (a benzodiazepine drug), phenylbutazone, and indomethacin by circular dichroism.	Bilirubin	68-77	albumin	Homo sapiens	30-33
863908-7	1977	In acetyl-HSA and O-deacetyl-HSA, the bilirubin binding is significantly decreased, while the binding of the drugs mentioned is less affected.	Bilirubin	38-47	albumin	Homo sapiens	10-13
863908-7	1977	In acetyl-HSA and O-deacetyl-HSA, the bilirubin binding is significantly decreased, while the binding of the drugs mentioned is less affected.	Bilirubin	38-47	albumin	Homo sapiens	29-32
18136-8	1977	Bilirubin binds to fragments P44 and P29, and the complexes show similar circular-dichroism spectra to that of the complex between bilirubin and whole albumin.	Bilirubin	0-9	SYF2 pre-mRNA splicing factor	Homo sapiens	37-40
557960-0	1977	Correlation of cord bilirubin levels with hyperbilirubinaemia in ABO incompatibility.	Bilirubin	20-29	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	65-68
557276-0	1977	Bilirubin displacing effect of stabilizers added to injectable preparations of human serum albumin.	Bilirubin	0-9	albumin	Homo sapiens	85-98
557960-1	1977	We studied 91 offspring of ABO incompatible preganacies and 30 controls resulting from O--O pregnancies to test whether cord bilirubin levels could be used to predict the severity of hyperbilirubinaemia in ABO incompatibility.	Bilirubin	125-134	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	206-209
557276-2	1977	It was found that N-acetyltryptophan and sodium caprylate displace bilirubin from its complex with human serum albumin in vitro.	Bilirubin	67-76	albumin	Homo sapiens	111-118
403586-1	1977	Addition of bilirubin in vitro to hepatic microsomes or 9,333 g supernatant activated UDP glucuronyltransferase activity (UDPGT) for p-nitrophenol of livers from Sprague-Dawley rats, Wistar rats, icteric Gunn rats and nonicteric Gunn rats.	Bilirubin	12-21	UDP glucuronosyltransferase family 2 member B15	Rattus norvegicus	122-127
557276-3	1977	The quantitative findings were used for a rough estimate of the effect of these substances on the free bilirubin concentration in blood plasma, expected when stabilized albumin preparations are given intravenously for prevention of kernicterus.	Bilirubin	103-112	albumin	Homo sapiens	169-176
831386-7	1977	These findings indicate that the increased amounts of unconjugated bilirubin in the intestine of jaundiced infants during light-treatment inhibit the intestinal brush-border lactase.	Bilirubin	67-76	lactase	Homo sapiens	174-181
843546-4	1977	In case of sera containing also conjugated pigment, the bilirubin adsorbed by the two gels was the same at a Br/Alb molar ratio equal to or below 0.89; above this level the bilirubin adsorbed by the Sephadex LH-20 was higher.	Bilirubin	56-65	albumin	Homo sapiens	112-115
13994-0	1977	Photooxidation of human serum albumin and its complex with bilirubin.	Bilirubin	59-68	albumin	Homo sapiens	30-37
13994-6	1977	Irradiation of a complex of human serum albumin with one molecule of bound bilirubin, in the absence of a sensitizing dye, resulted in a fast, non-oxygen consuming process whereby the light absorption maximum of the pigment was shifted 4 nm towards longer wavelength and part of the bilirubin was converted to a more polar pigment, bound less firmly to the protein.	Bilirubin	75-84	albumin	Homo sapiens	40-47
13994-6	1977	Irradiation of a complex of human serum albumin with one molecule of bound bilirubin, in the absence of a sensitizing dye, resulted in a fast, non-oxygen consuming process whereby the light absorption maximum of the pigment was shifted 4 nm towards longer wavelength and part of the bilirubin was converted to a more polar pigment, bound less firmly to the protein.	Bilirubin	283-292	albumin	Homo sapiens	40-47
602556-3	1977	It was demonstrated that bilirubin appears in the CSF only in jaundice of different etiology, cerebral hemorrhages and in blocking the liquor paths.	Bilirubin	25-34	colony stimulating factor 2	Homo sapiens	50-53
984122-0	1976	Accurate amniotic fluid bilirubin analysis from the "bloody tap".	Bilirubin	24-33	nuclear RNA export factor 1	Homo sapiens	60-64
787908-1	1976	Liver from normal Wistar rats was grafted into the liver of homozygous Gunn rats which are deficient in UDP glucuronyl transferase (UDPGT) (bilirubin) activity.	Bilirubin	140-149	UDP glucuronosyltransferase family 1 member A5	Rattus norvegicus	104-130
787908-1	1976	Liver from normal Wistar rats was grafted into the liver of homozygous Gunn rats which are deficient in UDP glucuronyl transferase (UDPGT) (bilirubin) activity.	Bilirubin	140-149	UDP glucuronosyltransferase family 1 member A5	Rattus norvegicus	132-137
787908-2	1976	After 3 months, UDPGT activity (bilirubin) remained absent in microsomal suspensions of liver from recipient rats and no bilirubin glucuronide was detected in their bile.	Bilirubin	32-41	UDP glucuronosyltransferase family 1 member A5	Rattus norvegicus	16-21
963887-0	1976	The interactions between iophenoxic acid, iopanoic acid, bilirubin and human serum albumin as studied by fluorescence and Sephadex gel filtration.	Bilirubin	57-66	albumin	Homo sapiens	77-90
963887-1	1976	Iophenoxic acid increases the fluorescence of bilirubin bound to human serum albumin at drug/albumin molar ratios lower than 1, while iopanoic acid decreases it.	Bilirubin	46-55	albumin	Homo sapiens	71-84
961953-3	1976	ABO disease, serious enough to cause an indirect serum bilirubin of 15 mg/100ml or higher, had an incidence in black newborns as great as the incidence of Rh hemolytic disease in whites.	Bilirubin	55-64	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	0-3
12064-6	1977	In addition, hyperbilirubinemia was found to be associated with depressed serum GGT activity, and bilirubin added to serum in vitro interfered with measured activity of the enzyme.	Bilirubin	18-27	inactive glutathione hydrolase 2	Homo sapiens	80-83
832018-1	1977	In a prospective study of 196 consecutive single births a significant increase in serum bilirubin concentrations was found in infants born after low amniotomy induction and oxytocin infusion compared with those born spontaneously.	Bilirubin	88-97	oxytocin/neurophysin I prepropeptide	Homo sapiens	173-181
844942-0	1977	Studies of the affinity of human serum albumin for binding of bilirubin at different temperatures and ionic strength.	Bilirubin	62-71	albumin	Homo sapiens	33-46
844942-1	1977	The association constants for the binding of bilirubin to human serum albumin (HSA) have been determined at four different temperatures by measurements of the rate of the peroxidase catalyzed oxidation of unbound bilirubin.	Bilirubin	45-54	albumin	Homo sapiens	64-83
844942-1	1977	The association constants for the binding of bilirubin to human serum albumin (HSA) have been determined at four different temperatures by measurements of the rate of the peroxidase catalyzed oxidation of unbound bilirubin.	Bilirubin	213-222	albumin	Homo sapiens	64-83
844942-4	1977	The results show that the large negative deltaG degrees (--11 kcal/mol) for binding of bilirubin to HSA is a consequence of the negative deltaH degrees.	Bilirubin	87-96	albumin	Homo sapiens	100-103
844942-8	1977	The data from the two sets of experiments suggest that hydrogen bonds and salt linkages rather than hydrophobic interactions are the main factor in the binding of bilirubin to its primary site on HSA.	Bilirubin	163-172	albumin	Homo sapiens	196-199
264670-3	1977	In the rat, the steroid isomerase is associated principally with the major transferase (B), which is also known as ligandin, and has the versatility to bind various hydrophobic compounds such as bilirubin, corticosteroids, and metabolites of a number of carcinogens.	Bilirubin	195-204	glutathione S-transferase alpha 2	Rattus norvegicus	115-123
1036328-1	1976	We describe the conditions for successful freeze-drying of bilirubin solutions in the presence of dimethylsulfoxide and human serum albumin.	Bilirubin	59-68	albumin	Homo sapiens	126-139
974106-0	1976	Bilirubin and biliverdin binding to rat Y protein (ligandin).	Bilirubin	0-9	glutathione S-transferase alpha 2	Rattus norvegicus	51-59
974106-3	1976	Comparison of the circular dichroism spectra of bilirubin bound to the hepatic protein ligandin with those of bilirubin complexed with albumin or polylysine indicates that binding of bilirubin to ligandin occurs at two types of sites.	Bilirubin	48-57	glutathione S-transferase alpha 2	Rattus norvegicus	87-95
974106-3	1976	Comparison of the circular dichroism spectra of bilirubin bound to the hepatic protein ligandin with those of bilirubin complexed with albumin or polylysine indicates that binding of bilirubin to ligandin occurs at two types of sites.	Bilirubin	48-57	glutathione S-transferase alpha 2	Rattus norvegicus	196-204
818610-8	1976	The present study shows that pathologic breast milk will inhibit BSP-Z protein binding only when stored under conditions that also cause the appearance of the capacity to inhibit bilirubin conjugation in vitro, as well as causing the liberation of nonesterified fatty acids.	Bilirubin	179-188	transmembrane BAX inhibitor motif containing 4	Homo sapiens	69-78
2595-0	1976	Affinity labeling of the primary bilirubin binding site of human serum albumin.	Bilirubin	33-42	albumin	Homo sapiens	65-78
1267008-9	1976	Circular dichroism studies with purified rat liver ligandin suggest that T3 and T4 bind competitively to the same site as does bilirubin; the association constants of T3 and T4 for ligandin are 10(6) and 10(5) M-1, respectively.	Bilirubin	127-136	glutathione S-transferase alpha 2	Rattus norvegicus	181-189
971583-0	1976	[Study of bilirubin kinetics in a case of Dubin-Johnson syndrome before and after treatment with UDPG].	Bilirubin	10-19	UDP-glucose pyrophosphorylase 2	Homo sapiens	97-101
1266978-3	1976	When bilirubin was constantly infused into the perfusion medium, which contained sheep erythrocytes and 3.0 g/100 ml bovine serum albumin, the maximal excretion rate for bilirubin was 14.4 +/- 1.2 mug/min per g liver.	Bilirubin	5-14	albumin	Ovis aries	124-137
1266978-3	1976	When bilirubin was constantly infused into the perfusion medium, which contained sheep erythrocytes and 3.0 g/100 ml bovine serum albumin, the maximal excretion rate for bilirubin was 14.4 +/- 1.2 mug/min per g liver.	Bilirubin	170-179	albumin	Ovis aries	124-137
176946-0	1976	Glyceraldehyde-3-phosphate dehydrogenase in the isolated human erthrocyte membrane: selective displacement by bilirubin.	Bilirubin	110-119	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	0-40
2595-1	1976	A label for the bilirubin binding sites of human serum albumin was synthesized by reacting 2 mol of Woodward"s reagent K (N-ethyl-5-phenylisoxazolium-3"-sulfonate) with 1 mol of bilirubin.	Bilirubin	16-25	albumin	Homo sapiens	49-62
2595-1	1976	A label for the bilirubin binding sites of human serum albumin was synthesized by reacting 2 mol of Woodward"s reagent K (N-ethyl-5-phenylisoxazolium-3"-sulfonate) with 1 mol of bilirubin.	Bilirubin	178-187	albumin	Homo sapiens	49-62
2595-6	1976	The absorption, fluorescence and CD spectra of the label in a complex with human serum albumin were similar to those of the bilirubin human serum albumin complex.	Bilirubin	124-133	albumin	Homo sapiens	140-153
782585-0	1976	The binding of bilirubin and other organic anions to serum albumin and ligandin (Y protein).	Bilirubin	15-24	albumin	Homo sapiens	59-66
1262-0	1975	Multiple forms of human glutathione S-transferase and their affinity for bilirubin.	Bilirubin	73-82	glutathione S-transferase kappa 1	Homo sapiens	24-49
943312-3	1976	When superimposed upon the CCl4 poisoning--the excretion of bilirubin diminishes.	Bilirubin	60-69	C-C motif chemokine ligand 4	Rattus norvegicus	27-31
943312-4	1976	The study compounds stimulated the passage of bilirubin with the bile following introduction of hemolyzed blood both in intact animals and in the ones with the CCl4-damaged liver.	Bilirubin	46-55	C-C motif chemokine ligand 4	Rattus norvegicus	160-164
1196709-0	1975	Ligandin reverses bilirubin inhibition of liver mitochondrial respiration in vitro.	Bilirubin	18-27	glutathione S-transferase alpha 2	Rattus norvegicus	0-8
1196709-1	1975	Ligandin, an abundant cytoplasmic binding protein of bilirubin and other ligands in liver cells, completely prevented the inhibitory effect of bilirubin on respiration and oxidative phosphorylation by isolated rat liver mitochondria.	Bilirubin	53-62	glutathione S-transferase alpha 2	Rattus norvegicus	0-8
1196709-1	1975	Ligandin, an abundant cytoplasmic binding protein of bilirubin and other ligands in liver cells, completely prevented the inhibitory effect of bilirubin on respiration and oxidative phosphorylation by isolated rat liver mitochondria.	Bilirubin	143-152	glutathione S-transferase alpha 2	Rattus norvegicus	0-8
1196709-4	1975	These studies suggest that ligandin may have a physiologic role in protecting mitochondrial systems against bilirubin toxicity.	Bilirubin	108-117	glutathione S-transferase alpha 2	Rattus norvegicus	27-35
1173645-7	1975	Serum alkaline phosphatase and bilirubin levels were significantly higher in the patients with elevated CEA levels (p smaller than .05).	Bilirubin	31-40	CEA cell adhesion molecule 3	Homo sapiens	104-107
1237311-4	1975	The strong bilirubin-binding site of bovine serum albumin is present in 3 of the 12 fragments.	Bilirubin	11-20	albumin	Homo sapiens	44-57
806301-5	1975	These findings demonstrate that UDPglucuronosyltransferase with bilirubin as substrate is a lipid-requiring enzyme.	Bilirubin	64-73	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	32-58
807500-1	1975	Reduction in caloric intake was associated with a greater absolute rise in the serum bilirubin concentration in patients with Gilbert"s syndrome and partial hepatic bilirubin uridine diphosphate glucuronyltransferase (UDPG-T) dysfunction compared to patients with hemolytic unconjugated hyperbilirubinemia and normal subjects.	Bilirubin	85-94	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	175-216
1188179-3	1975	The data suggest that although bilirubin, ICG and BSP bind to the intracellular hepatic transport protein ligandin one cannot achieve conditions in intact rats to demonstrate effects of competitive interaction with ligandin that affect plasma kinetics of these substances.	Bilirubin	31-40	glutathione S-transferase alpha 2	Rattus norvegicus	106-114
807304-11	1975	With use of the charcoal method, apparent dissociation constants for the interaction between Z-protein and hexachlorophene, bilirubin and L-thyroxine, were found to be 20, 50, and 350 muM, respectively.	Bilirubin	124-133	fatty acid binding protein 1	Rattus norvegicus	93-102
1148165-0	1975	Interactions of bilirubin and other ligands with ligandin.	Bilirubin	16-25	glutathione S-transferase alpha 2	Rattus norvegicus	49-57
1148165-11	1975	Some substances such as glutathione, conjugated sulfobromophthaleins and lithocholic acid bound to ligandin but induced anomalous spectral shifts, when added to ligandin-bilirubin complexes.	Bilirubin	170-179	glutathione S-transferase alpha 2	Rattus norvegicus	161-169
124327-4	1975	Inhibition of MLC responsiveness of 80.1 plus or minus 5.1% was also demonstrated at a bilirubin concentration of 20 mg/dl.	Bilirubin	87-96	modulator of VRAC current 1	Homo sapiens	14-17
1148165-5	1975	The bilirubin-ligandin complex exhibited a well-defined circular dichroic spectrum with two major overlapping ellipticity bands of opposite sign in the bilirubin absorption region.	Bilirubin	4-13	glutathione S-transferase alpha 2	Rattus norvegicus	14-22
1148165-5	1975	The bilirubin-ligandin complex exhibited a well-defined circular dichroic spectrum with two major overlapping ellipticity bands of opposite sign in the bilirubin absorption region.	Bilirubin	152-161	glutathione S-transferase alpha 2	Rattus norvegicus	14-22
1148165-7	1975	Studies on the direct transfer of bilirubin from ligandin to rat serum albumin showed that sasociation constants of bilirubin-ligandin complexes were approximately tenfold less than those of the bilirubin-albumin system.	Bilirubin	34-43	glutathione S-transferase alpha 2	Rattus norvegicus	49-57
1148165-7	1975	Studies on the direct transfer of bilirubin from ligandin to rat serum albumin showed that sasociation constants of bilirubin-ligandin complexes were approximately tenfold less than those of the bilirubin-albumin system.	Bilirubin	34-43	glutathione S-transferase alpha 2	Rattus norvegicus	126-134
1148165-7	1975	Studies on the direct transfer of bilirubin from ligandin to rat serum albumin showed that sasociation constants of bilirubin-ligandin complexes were approximately tenfold less than those of the bilirubin-albumin system.	Bilirubin	116-125	glutathione S-transferase alpha 2	Rattus norvegicus	49-57
1148165-7	1975	Studies on the direct transfer of bilirubin from ligandin to rat serum albumin showed that sasociation constants of bilirubin-ligandin complexes were approximately tenfold less than those of the bilirubin-albumin system.	Bilirubin	116-125	glutathione S-transferase alpha 2	Rattus norvegicus	126-134
1148165-7	1975	Studies on the direct transfer of bilirubin from ligandin to rat serum albumin showed that sasociation constants of bilirubin-ligandin complexes were approximately tenfold less than those of the bilirubin-albumin system.	Bilirubin	116-125	glutathione S-transferase alpha 2	Rattus norvegicus	49-57
1148165-7	1975	Studies on the direct transfer of bilirubin from ligandin to rat serum albumin showed that sasociation constants of bilirubin-ligandin complexes were approximately tenfold less than those of the bilirubin-albumin system.	Bilirubin	116-125	glutathione S-transferase alpha 2	Rattus norvegicus	126-134
1148165-10	1975	Most induced ellipticity changes consistent with competitive displacement of bilirubin from ligandin and relative affinities of these compounds for ligandin were determined based on their effectiveness in desplacing the bilirubin.	Bilirubin	220-229	glutathione S-transferase alpha 2	Rattus norvegicus	148-156
4472039-0	1974	Competitive binding of bilirubin, sulfobromophthalein, indocyanine green and other organic anions to human and bovine serum albumin.	Bilirubin	23-32	albumin	Homo sapiens	118-131
1168109-0	1975	[Lipoprotein lipase activity in human milk; inhibition in vitro of the glucuro-conjugation of bilirubin (author"s transl)].	Bilirubin	94-103	lipoprotein lipase	Homo sapiens	1-19
1168109-3	1975	However, lipoprotein lipase activity was increased only in samples provided from mothers whose infants had prolonged neonatal jaundice; after storage these samples inhibited the glucuro-conjugation of bilirubin in vitro and their concentration in non-esterified fatty acids was high.	Bilirubin	201-210	lipoprotein lipase	Homo sapiens	9-27
1140888-0	1975	Trinitrophenylation of the bilirubin binding site of human serum albumin.	Bilirubin	27-36	albumin	Homo sapiens	59-72
815919-2	1975	The activities of bilirubin UDP-glucuronosyl transferase and UDP-glucosyl transferase were reduced in microsomes of homozygous and heterozygous Gunn rats compared to Wistar rats (over 90 and 55-65%, respectively).	Bilirubin	18-27	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	28-56
1168914-0	1975	Bilirubin binding to hepatic Y and Z protein (ligandin): tissue bilirubin concentrations in phenobarbital treated Gunn rats (38466).	Bilirubin	0-9	glutathione S-transferase alpha 2	Rattus norvegicus	46-54
1168914-1	1975	NaP treatment significantly reduced plasma bilirubin levels in the (jj) Gunn rat.	Bilirubin	43-52	catenin, beta like 1	Rattus norvegicus	0-3
1168914-2	1975	It is suggested that NaP significantly increased extravascular bilirubin binding in the liver by induction of the synthesis of Y anion binding protein.	Bilirubin	63-72	catenin, beta like 1	Rattus norvegicus	21-24
1168914-3	1975	The changes in bilirubin concentration of blood and other tissues subsequent to NaP treatment were consistent with the establishment of a new tissue bilirubin equilibrium.	Bilirubin	15-24	catenin, beta like 1	Rattus norvegicus	80-83
1168914-3	1975	The changes in bilirubin concentration of blood and other tissues subsequent to NaP treatment were consistent with the establishment of a new tissue bilirubin equilibrium.	Bilirubin	149-158	catenin, beta like 1	Rattus norvegicus	80-83
4426122-0	1974	Determination of direct-reacting bilirubin on the SMA 12-60.	Bilirubin	33-42	survival of motor neuron 1, telomeric	Homo sapiens	50-53
4847810-0	1974	A theoretical analysis of the binding of bilirubin by human serum albumin: the contribution of the two binding sites.	Bilirubin	41-50	albumin	Homo sapiens	60-73
4834691-0	1974	Bilirubin binding to myelin basic protein, histones and its inhibition in vitro of cerebellar protein synthesis.	Bilirubin	0-9	myelin basic protein	Homo sapiens	21-41
4750105-1	1973	Biliverdin binding with respect to bilirubin and mechanism of bilirubin binding to bovine serum albumin.	Bilirubin	62-71	albumin	Homo sapiens	90-103
4854765-0	1974	The effect of lower aliphatic alcohols on the circular dichroism of the complex bilirubin-human serum albumin in aqueous solution.	Bilirubin	80-89	albumin	Homo sapiens	96-109
4842968-8	1974	It is suggested that flavaspidic acid acted on the hepatic uptake of bilirubin and BSP predominantly by competing for binding to Z protein.	Bilirubin	69-78	fatty acid binding protein 1	Rattus norvegicus	129-138
5460890-0	1970	Interactions of bilirubin with bovine serum albumin in aqueous solution.	Bilirubin	16-25	albumin	Homo sapiens	38-51
4664511-0	1972	Effect of antidiuretic hormone on the disappearance of exogenous bilirubin in the plasma.	Bilirubin	65-74	arginine vasopressin	Homo sapiens	10-30
5050660-0	1972	Chemical modification of the high-affinity bilirubin-binding site of human-serum albumin.	Bilirubin	43-52	albumin	Homo sapiens	81-88
5579629-0	1971	Bilirubin compounds in the CSF.	Bilirubin	0-9	colony stimulating factor 2	Homo sapiens	27-30
5507453-0	1970	[Bilirubin encephalopathy in the course of hemolytic disease of the newborn due to ABO incompatibility].	Bilirubin	1-10	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	83-86
5030343-0	1972	[Prognostic value of serum bilirubin in ABO incompatibility in the first few days postnatally].	Bilirubin	27-36	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	40-43
5005469-0	1971	[Reserve binding capacity of serum albumin for bilirubin in severe jaundice of the newborn infant].	Bilirubin	47-56	albumin	Homo sapiens	29-42
5500301-11	1970	However, this shift to 453nm can be explained on the basis of internal hydrogen bonds occurring between the carboxylic protons and the pyrrole rings of bilirubin, as proposed by Fog &amp; Jellum (1963), and new evidence for such a bonding has been accumulated.	Bilirubin	152-161	zinc finger protein, FOG family member 1	Homo sapiens	178-181
5527997-0	1970	[Sectetion of bilirubin in the bile induced by secretin].	Bilirubin	14-23	secretin	Homo sapiens	47-55
5706647-0	1968	Interaction of bromphenol blue and bilirubin with bovine and human serum albumin determined by gel filtration.	Bilirubin	35-44	albumin	Bos taurus	67-80
11947253-0	1969	Binding of bilirubin to human serum albumin - determination of the dissociation constants.	Bilirubin	11-20	albumin	Homo sapiens	30-43
6058723-0	1967	The effect of bilirubin concentration on determination of serum albumin.	Bilirubin	14-23	albumin	Homo sapiens	58-71
5606838-0	1967	[On Hb, reticulocyte, erythroblast and bilirubin levels in infants born of ABO incompatible pregnancies].	Bilirubin	39-48	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	75-78
5603211-2	1967	Its behavior after the threshold with free bilirubin in acutely intoxicated rats with CCl4].	Bilirubin	43-52	C-C motif chemokine ligand 4	Rattus norvegicus	86-90
5614555-0	1967	[On Hb, reticulocytes, erythroblasts and bilirubin levels in infants born from ABO compatible pregnancies].	Bilirubin	41-50	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	79-82
14277689-0	1965	EFFECT OF BILIRUBIN ON BINDING OF THYROXINE BY HUMAN SERUM ALBUMIN.	Bilirubin	10-19	albumin	Homo sapiens	53-66
6019868-0	1967	Plasma disappearance of conjugated and unconjugated C14 bilirubin in the rat with obstructive jaundice.	Bilirubin	56-65	anti-Mullerian hormone receptor type 2	Rattus norvegicus	52-55
4967427-0	1966	The blood plasma bilirubin level in premature infants and its connection with the isoantigenic compatibility of maternal and fetal blood in group ABO.	Bilirubin	17-26	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	146-149
14204456-0	1964	BINDING OF BILIRUBIN FROM RED CELL WITH GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY.	Bilirubin	11-20	glucose-6-phosphate dehydrogenase	Homo sapiens	40-73
14235824-0	1964	FURTHER STUDY ON BETA-GLUCURONIDASE ACTIVITY OF BILE IN CASES WITH CALCIUM BILIRUBINATE STONES.	Bilirubin	67-87	glucuronidase beta	Homo sapiens	17-35
14092499-0	1963	[EXTRACTION OF BILIRUBIN BY EXCHANGE TRANSFUSION AFTER INTRAVENOUS INJECTION OF ALBUMIN].	Bilirubin	15-24	albumin	Homo sapiens	80-88
14468710-0	1962	A study on the activity of beta-glucuronidase in bile in connection with precipitation of calcium bilirubinate.	Bilirubin	90-110	glucuronidase beta	Homo sapiens	27-45
14134461-0	1963	[SERUM LEUCINE AMINOPEPTIDASE ACTIVITY IN JAUNDICES IN NEWBORN AND OTHER INFANTS CAUSED BY REABSORPTION OF CONJUGATED BILIRUBIN].	Bilirubin	118-127	carboxypeptidase Q	Homo sapiens	15-29
20256192-0	1947	Determination of bilirubin in the umbilical blood as an aid in the early diagnosis of haemolytic disease in the newborn.	Bilirubin	17-26	activation induced cytidine deaminase	Homo sapiens	56-59
14466005-0	1962	[Blood bilirubin tables in fetal erythroblastosis caused by Rh and ABO incompatibility].	Bilirubin	7-16	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	67-70
14458319-0	1961	The antithrombin activity of glucuronic esters of bilirubin.	Bilirubin	50-59	serpin family C member 1	Homo sapiens	4-16
13528599-0	1958	[Reaction of fractionated bilirubin in blood &amp; of alkaline phosphatase in acute hepatitis treated with prednisone &amp; ACTH].	Bilirubin	26-35	proopiomelanocortin	Homo sapiens	124-128
20249190-0	1947	Effect of pentaerythritetranitrate on pain and elevations of serum amylase and bilirubin induced by simultaneous injections of morphine hydrochloride and secretin in patients with biliary dyskinesia.	Bilirubin	79-88	secretin	Homo sapiens	154-162
13973287-0	1962	[Studies on hepatic cholesterol esterase: inhibition induced by bilirubin].	Bilirubin	64-73	carboxyl ester lipase	Homo sapiens	20-40
13690752-0	1961	[Influence of ACTH and corticoids on the hepatic conjugation of bilirubin in the newborn.	Bilirubin	64-73	proopiomelanocortin	Homo sapiens	14-18
33753214-1	2021	Multidrug resistance-associated protein (MRP; ABCC gene family) mediated efflux transport plays an important role in the systemic and tissue exposure profiles of many drugs and their metabolites, and also of endogenous compounds like bile acids and bilirubin conjugates.	Bilirubin	249-258	ATP binding cassette subfamily C member 2	Rattus norvegicus	0-39
33753214-1	2021	Multidrug resistance-associated protein (MRP; ABCC gene family) mediated efflux transport plays an important role in the systemic and tissue exposure profiles of many drugs and their metabolites, and also of endogenous compounds like bile acids and bilirubin conjugates.	Bilirubin	249-258	ATP binding cassette subfamily C member 2	Rattus norvegicus	41-44
33393716-0	2021	Albumin-bilirubin score for predicting neuropsychiatric symptoms in patients receiving ifosfamide-based chemotherapy.	Bilirubin	8-17	albumin	Homo sapiens	0-7
34011630-7	2021	Obesity with insulin resistance up-regulated hepatic ABCB10 expression in mice and elevated cytosolic and mitochondrial bilirubin content in an ABCB10-dependent manner.	Bilirubin	120-129	ATP-binding cassette, sub-family B (MDR/TAP), member 10	Mus musculus	144-150
33484436-14	2021	CONCLUSION: The precise mechanism accountable for the anti-inflammatory features of HO-1 is not completely understood; nevertheless, the CO signaling function associated with the antioxidant property shown by bilirubin possibly will play an act in the improvement of inflammation.	Bilirubin	209-218	heme oxygenase 1	Homo sapiens	84-88
33888467-2	2021	We show that SARS-CoV-2 spike binds biliverdin and bilirubin, the tetrapyrrole products of haem metabolism, with nanomolar affinity.	Bilirubin	51-60	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	24-29
34045606-4	2021	Treatment of hUGT1*1 mice with UDCA or OCA at postnatal days 10-14 effectively decreased bilirubin in plasma (by 82% and 62%) and brain (by 72% and 69%), respectively.	Bilirubin	89-98	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	13-18
33503489-15	2021	The SURFASA score -6.80+1.92*(D0-INR) +1.94*(Delta%3-INR)+ 1.64*(Delta%3-bilirubin), created by combining these variables, was highly predictive of LT or death (AUC=0.93) (88% specificity; 84% sensitivity) with a cut-off point of <-0.9.	Bilirubin	73-82	delta like canonical Notch ligand 3	Homo sapiens	65-72
34032735-6	2021	Further analysis showed that hypomethylation of the UBE2Q1 promoter was positively correlated with total bilirubin and international normalized ratio levels in patients with pre-ACHBLF, but negatively correlated with PTA level.	Bilirubin	105-114	ubiquitin conjugating enzyme E2 Q1	Homo sapiens	52-58
33631237-3	2021	The present study aimed to determine the genotype of the UGT1A1 promoter and exon that are related to the serum total bilirubin (STB) level in the Chinese Han population.	Bilirubin	118-127	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	57-63
34011630-8	2021	Revealing a maladaptive role of ABCB10-driven bilirubin synthesis, hepatic ABCB10 deletion protected diet-induced obese mice from steatosis and hyperglycemia, improving insulin-mediated suppression of glucose production and decreasing lipogenic SREBP-1c expression.	Bilirubin	46-55	ATP-binding cassette, sub-family B (MDR/TAP), member 10	Mus musculus	32-38
34011630-10	2021	Restoration of cellular bilirubin content in ABCB10 KO hepatocytes reversed the improvements in mitochondrial function and PTP1B inactivation, demonstrating that bilirubin was the maladaptive effector linked to ABCB10 function.	Bilirubin	24-33	ATP-binding cassette, sub-family B (MDR/TAP), member 10	Mus musculus	45-51
34011630-10	2021	Restoration of cellular bilirubin content in ABCB10 KO hepatocytes reversed the improvements in mitochondrial function and PTP1B inactivation, demonstrating that bilirubin was the maladaptive effector linked to ABCB10 function.	Bilirubin	24-33	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	123-128
34011630-10	2021	Restoration of cellular bilirubin content in ABCB10 KO hepatocytes reversed the improvements in mitochondrial function and PTP1B inactivation, demonstrating that bilirubin was the maladaptive effector linked to ABCB10 function.	Bilirubin	24-33	ATP-binding cassette, sub-family B (MDR/TAP), member 10	Mus musculus	211-217
34011630-10	2021	Restoration of cellular bilirubin content in ABCB10 KO hepatocytes reversed the improvements in mitochondrial function and PTP1B inactivation, demonstrating that bilirubin was the maladaptive effector linked to ABCB10 function.	Bilirubin	162-171	ATP-binding cassette, sub-family B (MDR/TAP), member 10	Mus musculus	45-51
34011630-10	2021	Restoration of cellular bilirubin content in ABCB10 KO hepatocytes reversed the improvements in mitochondrial function and PTP1B inactivation, demonstrating that bilirubin was the maladaptive effector linked to ABCB10 function.	Bilirubin	162-171	ATP-binding cassette, sub-family B (MDR/TAP), member 10	Mus musculus	211-217
33960691-2	2021	We elucidated usefulness of newly developed albumin-bilirubin (ALBI) score as alternative methods of BTR in patients with naive hepatocellular carcinoma (HCC) retrospectively.	Bilirubin	52-61	albumin	Homo sapiens	44-51
33986443-9	2021	There was a significant bilirubin reduction as well in the CS group (p < 0.001, median relative reduction: 22.5%) as in the ADVOS group (p = 0.028, median relative reduction: 22.8%).	Bilirubin	24-33	citrate synthase	Homo sapiens	59-61
33986443-11	2021	The use of CytoSorb and ADVOS in patients with ALD led to a significant and comparable decrease in total bilirubin.	Bilirubin	105-114	citrate synthase	Homo sapiens	11-19
33080074-9	2021	In particular, conjugated bilirubin not only directly promoted MAIT cell activation and apoptosis, but also impaired TCR-induced proliferation and expansion of MAIT cells which could be partially rescued by IL-2 in the absence of conjugated bilirubin.	Bilirubin	26-35	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	117-120
34040515-6	2021	SF1 induced a significant rise in Alkaline Phosphatases (ALP), bilirubin, white blood cells (WBC), and lymphocyte levels with a decrease in platelet count.	Bilirubin	63-72	splicing factor 1	Rattus norvegicus	0-3
33961837-0	2021	UGT1A1 dysfunction increases liver burden and aggravates hepatocyte damage caused by long-term bilirubin metabolism disorder.	Bilirubin	95-104	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	0-6
33961837-1	2021	UGT1A1 is the only enzyme that can metabolize bilirubin, and its encoding gene is frequently mutated.	Bilirubin	46-55	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	0-6
33961837-2	2021	UGT1A1*6 (G71R) is a common mutant in Asia which leads to the decrease of UGT1A1 activity and abnormal bilirubin metabolism.	Bilirubin	103-112	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	0-6
33961837-6	2021	In the animal experiment with a continuous intraperitoneal injection of bilirubin, the ugt1a+/- mice livers had more serious unconjugated bilirubin accumulation.	Bilirubin	72-81	Ugt1a@	Mus musculus	87-92
33961837-6	2021	In the animal experiment with a continuous intraperitoneal injection of bilirubin, the ugt1a+/- mice livers had more serious unconjugated bilirubin accumulation.	Bilirubin	138-147	Ugt1a@	Mus musculus	87-92
33961837-7	2021	The accumulated bilirubin leads to hyperphosphorylation of IkappaB-alpha, Ikk-beta, and p65 and a significant increase of inflammatory factor.	Bilirubin	16-25	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	59-72
33961837-7	2021	The accumulated bilirubin leads to hyperphosphorylation of IkappaB-alpha, Ikk-beta, and p65 and a significant increase of inflammatory factor.	Bilirubin	16-25	conserved helix-loop-helix ubiquitous kinase	Mus musculus	74-82
33961837-7	2021	The accumulated bilirubin leads to hyperphosphorylation of IkappaB-alpha, Ikk-beta, and p65 and a significant increase of inflammatory factor.	Bilirubin	16-25	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	88-91
33961837-10	2021	Comprehensive results show that there was a crosstalk relationship between low UGT1A1 activity-bilirubin-liver damage.	Bilirubin	95-104	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	79-85
33961837-11	2021	Furthermore, cell experiments confirmed that unconjugated bilirubin activated the NF-kappaB pathway and induced DNA damage in hepatocytes, leading to the significant increase of inflammatory factors.	Bilirubin	58-67	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	82-91
33961837-12	2021	UGT1A1 knockdown in hepatocytes aggravated the toxicity of unconjugated bilirubin.	Bilirubin	72-81	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	0-6
31739363-5	2021	Also, significant difference was found in the level of serum indirect bilirubin among G6PD-deficient neonate in comparison to G6PD nondeficient neonates which had contributed significantly to the difference in the duration of phototherapy and hospitalization among deficient neonate.	Bilirubin	70-79	glucose-6-phosphate dehydrogenase	Homo sapiens	86-90
33080074-9	2021	In particular, conjugated bilirubin not only directly promoted MAIT cell activation and apoptosis, but also impaired TCR-induced proliferation and expansion of MAIT cells which could be partially rescued by IL-2 in the absence of conjugated bilirubin.	Bilirubin	26-35	interleukin 2	Homo sapiens	207-211
33080074-10	2021	Albeit MAIT cells from patients with high conjugated bilirubin level showed decreased cytokine producing capacity, the increased TCR-dependent antiviral cytokine production suggested MAIT cell as an important guardian of chronic hepatitis B with high conjugated bilirubin.	Bilirubin	262-271	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	129-132
32937649-5	2021	L1 activation of ERK1/2 was measured in CGN in the presence or absence of bilirubin.	Bilirubin	74-83	mitogen activated protein kinase 3	Rattus norvegicus	17-23
33534365-1	2021	OBJECTIVES: Dubin-Johnson syndrome (DJS) is an autosomal recessive disorder in which multidrug-resistance-associated protein 2 (MRP2) deficiency causes an excretion disorder of conjugated bilirubin from hepatocytes into bile canaliculi.	Bilirubin	188-197	ATP binding cassette subfamily C member 2	Homo sapiens	85-126
33534365-1	2021	OBJECTIVES: Dubin-Johnson syndrome (DJS) is an autosomal recessive disorder in which multidrug-resistance-associated protein 2 (MRP2) deficiency causes an excretion disorder of conjugated bilirubin from hepatocytes into bile canaliculi.	Bilirubin	188-197	ATP binding cassette subfamily C member 2	Homo sapiens	128-132
32937649-8	2021	L1 activation of ERK1/2 was inhibited by bilirubin.	Bilirubin	41-50	mitogen activated protein kinase 3	Rattus norvegicus	17-23
32937649-26	2021	4PHYSIOLOGIC BILIRUBIN CONCENTRATIONS INHIBIT L1 ACTIVATION OF ERK1/2.	Bilirubin	13-22	mitogen activated protein kinase 3	Rattus norvegicus	63-69
33027804-3	2021	The homozygous Gunn rat lacks uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1), the enzyme needed to biotransform bilirubin.	Bilirubin	122-131	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	30-77
33027804-3	2021	The homozygous Gunn rat lacks uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1), the enzyme needed to biotransform bilirubin.	Bilirubin	122-131	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	79-85
34007799-0	2021	UGT1A1-related Bilirubin Encephalopathy/Kernicterus in Adults.	Bilirubin	15-24	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
33837620-6	2021	RESULTS: Serum albumin level at the start of regorafenib and reasons for discontinuation of regorafenib were significantly different between the R-L and non-R-L groups, whereas albumin-bilirubin (ALBI) score, Child-Pugh class, and tumor burden were not.	Bilirubin	185-194	albumin	Homo sapiens	177-184
33900625-6	2021	Perinatal deletion of Thm1 in Pkd2 conditional knock-out mice increased hepatomegaly, liver necrosis, as well as serum bilirubin and bile acid levels, indicating enhanced liver disease severity.	Bilirubin	119-128	tetratricopeptide repeat domain 21B	Mus musculus	22-26
33900625-6	2021	Perinatal deletion of Thm1 in Pkd2 conditional knock-out mice increased hepatomegaly, liver necrosis, as well as serum bilirubin and bile acid levels, indicating enhanced liver disease severity.	Bilirubin	119-128	polycystin 2, transient receptor potential cation channel	Mus musculus	30-34
33931320-6	2021	Age-adjusted logistic regression showed mSEPT9 was associated with age, body mass index, HCC, liver cirrhosis, AFP, platelets, neutrophil-to-lymphocyte-ratio, albumin-bilirubin grade and fibrosis-4 index (p < 0.05).	Bilirubin	167-176	septin 9	Mus musculus	40-46
33901188-10	2021	We replicated several proof-of-concept transcriptionally regulated gene-trait associations, including UGT1A1 (encoding bilirubin uridine diphosphate glucuronosyltransferase enzyme) and total bilirubin levels (p = 3.59x10-12), and CETP (cholesteryl ester transfer protein) with high-density lipoprotein cholesterol (p = 4.49x10-12).	Bilirubin	119-128	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	102-108
33923744-1	2021	Heme-oxygenase is the enzyme responsible for degradation of endogenous iron protoporphyirin heme; it catalyzes the reaction"s rate-limiting step, resulting in the release of carbon monoxide (CO), ferrous ions, and biliverdin (BV), which is successively reduced in bilirubin (BR) by biliverdin reductase.	Bilirubin	264-273	chromosome 12 open reading frame 73	Homo sapiens	275-277
33848667-8	2021	Matched patients with consistently low ALP levels had significantly lower serum aminotransferase and bilirubin levels at their initial visit and throughout the follow-up period (p<0.05 respectively) while Fib-4 levels and MELD scores were similar at the initial and last follow-up visit.	Bilirubin	101-110	alkaline phosphatase, placental	Homo sapiens	39-42
33529650-2	2021	CAR interacts with key signalling pathways such as those involved in drug, energy and bilirubin metabolism.	Bilirubin	86-95	nuclear receptor subfamily 1 group I member 3	Homo sapiens	0-3
33965236-10	2021	HSC count increased 12-fold and 17.5-fold for the 5 mug/kg and10 ug/kg dose respectively; with respective median total bilirubin levels for GCSF vs no-GCSF groups of 55 vs 91 muM at 1 month, p = 0.05; 15 vs 37 muM at 3 months, p = 0.24); and the 6-months cholangitis frequency of 40% vs 90%, p = 0.077.	Bilirubin	119-128	colony stimulating factor 3	Homo sapiens	140-144
33616244-7	2021	In the entire cohort, variants in PNPLA3 and HP were associated with increased total bilirubin and Model for End-stage Liver Disease (MELD) score, two measures of AH severity.	Bilirubin	85-94	patatin like phospholipase domain containing 3	Homo sapiens	34-40
33616244-9	2021	CONCLUSION: The current study demonstrates that PNPLA3 and HP genetic variants increase AH risk and are associated with total bilirubin and MELD score, surrogates of AH severity.	Bilirubin	126-135	patatin like phospholipase domain containing 3	Homo sapiens	48-54
33829974-5	2021	Free bilirubin can also function as an agonist for the aryl hydrocarbon receptor (AhR); this may explain its ability to promote protective Treg activity in cellular and rodent models of inflammatory disease.	Bilirubin	5-14	aryl hydrocarbon receptor	Homo sapiens	55-80
33829974-5	2021	Free bilirubin can also function as an agonist for the aryl hydrocarbon receptor (AhR); this may explain its ability to promote protective Treg activity in cellular and rodent models of inflammatory disease.	Bilirubin	5-14	aryl hydrocarbon receptor	Homo sapiens	82-85
33780835-2	2021	In a derivation study, the ABP criteria (Albumin >40 g/l, Bilirubin <22 mumol/l and Platelet >114,000/mul) had been shown to perform well in identifying compensated advanced chronic liver disease (cACLD) patients without high-risk varices (HRV).	Bilirubin	58-67	amine oxidase copper containing 1	Homo sapiens	27-30
33869168-2	2021	This study was aim to investigate the mechanism of bilirubin in cholestasis mediating pain desensitization through 5-hydroxytryptamine 3A (5-HT3A ) receptor activation in spinal dorsal horn (SDH).	Bilirubin	51-60	5-hydroxytryptamine receptor 3A	Rattus norvegicus	115-137
33869168-2	2021	This study was aim to investigate the mechanism of bilirubin in cholestasis mediating pain desensitization through 5-hydroxytryptamine 3A (5-HT3A ) receptor activation in spinal dorsal horn (SDH).	Bilirubin	51-60	5-hydroxytryptamine receptor 3A	Homo sapiens	139-145
33869168-5	2021	Expression of 5-HT3 receptors, and the affinity and binding mode of bilirubin to 5-HT3A receptor were determined.	Bilirubin	68-77	5-hydroxytryptamine receptor 3A	Rattus norvegicus	81-87
33869168-9	2021	Further, 5-HT3A and GABA A receptor expressions were increased in BDL rats or intervention with bilirubin.	Bilirubin	96-105	5-hydroxytryptamine receptor 3A	Rattus norvegicus	9-15
33869168-10	2021	Molecular docking suggested that bilirubin entered the hydrophobic pocket pre-formed in 5-HT3A receptor with potential hydrogen bonding.	Bilirubin	33-42	5-hydroxytryptamine receptor 3A	Rattus norvegicus	88-94
33869168-11	2021	Bilirubin also increased GABA concentrations in CSF and GABAergic spontaneous inhibitory postsynaptic current in spinal cord, and directly induced inward currents in HEK293 cells which were overexpressed 5-HT3A receptor by lentivirus.	Bilirubin	0-9	5-hydroxytryptamine receptor 3A	Homo sapiens	204-210
33869168-12	2021	Conclusion: In conclusion, bilirubin induced pain desensitization in cholestasis by activating 5-HT3A receptor in spinal cord.	Bilirubin	27-36	5-hydroxytryptamine receptor 3A	Homo sapiens	95-101
33210382-6	2021	Treatment was well tolerated; most common treatment-emergent grade 3-4 adverse-events occurring in >1 patient with 625mg/m2 NUC-1031 were increased GGT: 40%, ALT: 20%, bilirubin: 13%, neutropenia: 27%, decreased WCC: 20%, thrombocytopenia: 13%, nausea: 13%, diarrhea: 13%, fatigue: 13%, and thrombus: 20% and with 725mg/m2 , increased GGT: 67% and fatigue: 33%.	Bilirubin	168-177	nucleobindin 1	Homo sapiens	124-127
33485635-10	2021	We found that blood pressure, cholesterol, C-reactive protein, alcohol and white blood cell count played important roles in the causal pathway from bilirubin to CVD.	Bilirubin	148-157	C-reactive protein	Homo sapiens	43-61
33742751-10	2021	The strongest independent predictors for higher concentration of DPP3 were log ALT, log-total bilirubin, the absence of diabetes, higher osteopontin FGF-23 and NT pro BNP concentrations (all p < 0.001).	Bilirubin	94-103	dipeptidyl peptidase 3	Homo sapiens	65-69
33737608-3	2021	This report describes the characteristic photochemical kinetics of bilirubin under green-spectrum LEDs in human, rat, rabbit, dog, pig, sheep, bovine and chicken serum albumin and rhesus monkey serum.	Bilirubin	67-76	albumin	Bos taurus	162-175
34027124-7	2021	BDNF showed a negative correlation with bilirubin (R = -0.35, p = 0.005) and international normalized ratio (INR) (R = -0.37, p = 0.003), and positive with platelets (PLT) (R = 0.36, p = 0.004), while no associations with age, sex, body mass index (BMI), waist-hip ratio (WHR), creatinine and ammonia were noted.	Bilirubin	40-49	brain derived neurotrophic factor	Homo sapiens	0-4
33546617-15	2021	In particular, the patients with two mutations in ABC family genes had higher average values of total bile acids (TBA), aspartate transaminase (AST), direct bilirubin (DBIL), total cholesterol (CHOL), triglycerides (TG) and high-density lipoprotein (HDL) than the patients who had one mutation, no mutation in ABC genes and local controls.	Bilirubin	157-166	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	50-53
33842242-1	2021	Background: Ratio of carbohydrate antigen 19-9 level to total bilirubin (CA19-9/TB) is used to reduce the influence of obstructive jaundice on the concentration of CA19-9, thereby determining the correlation between CA19-9/TB and tumor recurrence or long-term prognosis of patients with pancreatic head cancer (PHC).	Bilirubin	62-71	tyrosinase related protein 1	Homo sapiens	73-82
33842242-1	2021	Background: Ratio of carbohydrate antigen 19-9 level to total bilirubin (CA19-9/TB) is used to reduce the influence of obstructive jaundice on the concentration of CA19-9, thereby determining the correlation between CA19-9/TB and tumor recurrence or long-term prognosis of patients with pancreatic head cancer (PHC).	Bilirubin	62-71	tyrosinase related protein 1	Homo sapiens	216-225
33685083-1	2021	Objective: To investigate the diagnosis method of Gilbert syndrome (GS) and the relationship between UGT1A1 gene polymorphism distribution with serum bilirubin.	Bilirubin	150-159	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	101-107
33685083-6	2021	Among 110 cases with Gilbert syndrome combined with non-hemolytic diseases, pairwise comparisons showed that the total bilirubin levels of patients with UGT1A1*28/*28 mutations were significantly higher than UGT1A1*6/*6 and UGT1A1*1/*28 + *1/*6 mutation (P < 0.05).	Bilirubin	119-128	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	153-159
33685083-6	2021	Among 110 cases with Gilbert syndrome combined with non-hemolytic diseases, pairwise comparisons showed that the total bilirubin levels of patients with UGT1A1*28/*28 mutations were significantly higher than UGT1A1*6/*6 and UGT1A1*1/*28 + *1/*6 mutation (P < 0.05).	Bilirubin	119-128	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	208-214
33685083-6	2021	Among 110 cases with Gilbert syndrome combined with non-hemolytic diseases, pairwise comparisons showed that the total bilirubin levels of patients with UGT1A1*28/*28 mutations were significantly higher than UGT1A1*6/*6 and UGT1A1*1/*28 + *1/*6 mutation (P < 0.05).	Bilirubin	119-128	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	208-214
33685083-7	2021	Additionally, with the increase of UGT1A1*28 distribution, the serum total bilirubin level had gradually increased (P = 0.028), but UGT1A1*6 was opposite (P = 0.021).	Bilirubin	75-84	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	35-41
33591961-0	2021	Accuracy of transcutaneous bilirubin measurement in full-term newborns at 3400 meters above sea level.	Bilirubin	27-36	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	92-95
33591961-12	2021	CONCLUSIONS: Measurement of transcutaneous bilirubin is a fast and painless method that can be considered a reliable tool for screening and monitoring neonatal jaundice, but not for a definitive diagnosis to decide the use of phototherapy in full-term newborns at 3400 m above sea level.	Bilirubin	43-52	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	277-280
33571217-8	2021	RESULTS: In univariate analysis, a significant difference was found among NDR, SDR and PDR in bilirubin levels, duration of diabetes, systolic blood pressure, and macroalbuminuria.	Bilirubin	94-103	caveolae associated protein 2	Homo sapiens	79-82
33571217-8	2021	RESULTS: In univariate analysis, a significant difference was found among NDR, SDR and PDR in bilirubin levels, duration of diabetes, systolic blood pressure, and macroalbuminuria.	Bilirubin	94-103	PDR	Homo sapiens	87-90
33571217-9	2021	Logistic regression analysis showed that PDR was significantly associated with bilirubin levels, duration of diabetes, and systolic blood pressure (OR 0.737, 95% CI 0.570-0.952, P = 0.012; OR 1.085, 95% CI 1.024-1.149, P = 0.006; OR 1.036, 95% CI 1.011-1.062, P = 0.005, respectively).	Bilirubin	79-88	PDR	Homo sapiens	41-44
33571217-10	2021	In turn, multivariate regression analysis showed that bilirubin levels were negatively associated with high-sensitivity C-reactive protein levels and PDR, but positively correlated with urinary biopyrrin levels, oxidized metabolites of bilirubin.	Bilirubin	54-63	C-reactive protein	Homo sapiens	120-138
33571217-10	2021	In turn, multivariate regression analysis showed that bilirubin levels were negatively associated with high-sensitivity C-reactive protein levels and PDR, but positively correlated with urinary biopyrrin levels, oxidized metabolites of bilirubin.	Bilirubin	54-63	PDR	Homo sapiens	150-153
33571217-11	2021	CONCLUSION: PDR was negatively associated with bilirubin levels.	Bilirubin	47-56	PDR	Homo sapiens	12-15
33635234-10	2022	Meanwhile, correlation analysis reveals that circulating miR-22-3p positively correlates with haemoglobin, serum bilirubin, albumin and IL-17 but negatively correlates with mean platelet volume as well as let-7a-5p.	Bilirubin	113-122	microRNA 223	Homo sapiens	57-66
33360868-6	2021	Also, our study shows the area under the curve and the diagnostic accuracy of total serum bilirubin (TSB) level for detection of hearing screening results (ABR) at a cut-off point 21 mg/dl (P-value = 0.008 and 0.009 in the right and left ears respectively.)	Bilirubin	90-99	ABR activator of RhoGEF and GTPase	Homo sapiens	156-159
33022821-8	2021	Anti-gp210 auto-antibodies were significantly associated with elevated hepatic aminotransferases, bilirubin, and liver stiffness at presentation (P<0.010).	Bilirubin	98-107	nucleoporin 210	Homo sapiens	5-10
33716792-8	2021	The regulatory role of heme availability for the synthesis of enzymes involved in hypertension development, such as cyclooxygenase or nitric oxide synthase, seems to be responsible for many of the beneficial HO-1 effects; additionally, the antioxidant, anti-inflammatory, antiapoptotic, and antiproliferative effects of the end products of its reaction, carbon monoxide, biliverdin/bilirubin, and Fe2+, would also contribute.	Bilirubin	382-391	heme oxygenase 1	Homo sapiens	208-212
33254233-6	2021	Heme deficiency also impairs heme oxygenase-1 (HO-1) expression, which reduces levels of important heme catabolites such as biliverdin and bilirubin.	Bilirubin	139-148	heme oxygenase 1	Mus musculus	29-45
33254233-6	2021	Heme deficiency also impairs heme oxygenase-1 (HO-1) expression, which reduces levels of important heme catabolites such as biliverdin and bilirubin.	Bilirubin	139-148	heme oxygenase 1	Mus musculus	47-51
33571217-8	2021	RESULTS: In univariate analysis, a significant difference was found among NDR, SDR and PDR in bilirubin levels, duration of diabetes, systolic blood pressure, and macroalbuminuria.	Bilirubin	94-103	serine/threonine kinase 38	Homo sapiens	74-77
33558655-7	2021	In human cerebral microvascular endothelial cells, NH4Cl plus unconjugated bilirubin significantly decreased BCRP function and expression of membrane BCRP protein, but upregulated P-gp function and expression of membrane P-gp protein.	Bilirubin	75-84	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	109-113
33558655-7	2021	In human cerebral microvascular endothelial cells, NH4Cl plus unconjugated bilirubin significantly decreased BCRP function and expression of membrane BCRP protein, but upregulated P-gp function and expression of membrane P-gp protein.	Bilirubin	75-84	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	150-154
33558655-7	2021	In human cerebral microvascular endothelial cells, NH4Cl plus unconjugated bilirubin significantly decreased BCRP function and expression of membrane BCRP protein, but upregulated P-gp function and expression of membrane P-gp protein.	Bilirubin	75-84	phosphoglycolate phosphatase	Homo sapiens	180-184
33558655-7	2021	In human cerebral microvascular endothelial cells, NH4Cl plus unconjugated bilirubin significantly decreased BCRP function and expression of membrane BCRP protein, but upregulated P-gp function and expression of membrane P-gp protein.	Bilirubin	75-84	phosphoglycolate phosphatase	Homo sapiens	221-225
33628187-0	2020	Neobavaisoflavone Induces Bilirubin Metabolizing Enzyme UGT1A1 via PPARalpha and PPARgamma.	Bilirubin	26-35	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	56-62
33628187-0	2020	Neobavaisoflavone Induces Bilirubin Metabolizing Enzyme UGT1A1 via PPARalpha and PPARgamma.	Bilirubin	26-35	peroxisome proliferator activated receptor alpha	Homo sapiens	67-76
33628187-0	2020	Neobavaisoflavone Induces Bilirubin Metabolizing Enzyme UGT1A1 via PPARalpha and PPARgamma.	Bilirubin	26-35	peroxisome proliferator activated receptor gamma	Homo sapiens	81-90
33628187-1	2020	UDP-glucuronosyltransferase 1A1 (UGT1A1) is an essential enzyme in mammals that is responsible for detoxification and metabolic clearance of the endogenous toxin bilirubin and a variety of xenobiotics, including some crucial therapeutic drugs.	Bilirubin	162-171	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-31
33628187-1	2020	UDP-glucuronosyltransferase 1A1 (UGT1A1) is an essential enzyme in mammals that is responsible for detoxification and metabolic clearance of the endogenous toxin bilirubin and a variety of xenobiotics, including some crucial therapeutic drugs.	Bilirubin	162-171	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	33-39
33126288-7	2021	In women, the median age at diagnosis increased incrementally from 54.0 years (<=1999) to 60.5 years (>=2010) (P<0.001) and serum albumin decreased gradually (P=0.001), which might have affected the increase in the FIB-4 index and albumin-bilirubin score.	Bilirubin	239-248	albumin	Homo sapiens	124-137
33398528-8	2021	Based on a generalized estimating equations analysis model with time interaction considered, the only significant factor associated with changes in phenylalanine was changes in C-reactive protein concentrations from baseline to 12 months [B (coefficient) = 0.81, P < 0.001] after adjusting for methionine sulfoxide and total bilirubin levels.	Bilirubin	325-334	C-reactive protein	Homo sapiens	177-195
33057809-0	2021	Assessment of the Outcomes of Intrahepatic Cholangiocarcinoma After Ultrasound-Guided Percutaneous Microwave Ablation Based on Albumin-Bilirubin Grade.	Bilirubin	135-144	albumin	Homo sapiens	127-134
33098209-10	2021	Spearman correlation showed a positive correlation between AFP, age, AST, Bilirubin, creatinine, INR.	Bilirubin	74-83	alpha fetoprotein	Homo sapiens	59-62
32943763-12	2021	Correlation analysis demonstrated that IGF2 was significantly associated with total bilirubin, direct bilirubin, and albumin at T0 while with blood glucose, ALT, GGT, and AST/ALT ratio at T6M and T12M.	Bilirubin	84-93	insulin like growth factor 2	Homo sapiens	39-43
32943763-12	2021	Correlation analysis demonstrated that IGF2 was significantly associated with total bilirubin, direct bilirubin, and albumin at T0 while with blood glucose, ALT, GGT, and AST/ALT ratio at T6M and T12M.	Bilirubin	102-111	insulin like growth factor 2	Homo sapiens	39-43
32961633-8	2021	KIR2DL2-positive patients had high median levels of AST after treatment and direct bilirubin levels when compared to KIR2DL2-negative patients (p = .013, respectively, p = .028).	Bilirubin	83-92	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2	Homo sapiens	0-7
33323685-2	2021	Hepatobiliary ATP-binding cassette (ABC) transporters play an important role in the transportation of many drugs and bilirubin, however little is known about these transporters and the risk of DILI.	Bilirubin	117-126	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	14-34
33323685-2	2021	Hepatobiliary ATP-binding cassette (ABC) transporters play an important role in the transportation of many drugs and bilirubin, however little is known about these transporters and the risk of DILI.	Bilirubin	117-126	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	36-39
33433133-2	2021	We aimed to investigate the role of the albumin-bilirubin (ALBI) grade in predicting outcomes in patients with BCLC stage 0 HCC.	Bilirubin	48-57	albumin	Homo sapiens	40-47
32827564-8	2021	After PSM, recipients with simultaneous Spx showed lower early graft dysfunction frequency on POD 7 (p=0.04), lower SFSG syndrome frequency (p=0.01), lower serum total bilirubin levels (p=0.001), and lower international normalized ratio (p=0.004) on POD 14, lower sepsis (p=0.02) frequency within 6 months after LDLT, and better graft survival rates (p=0.04) compared with those without Spx.	Bilirubin	168-177	spexin hormone	Homo sapiens	40-43
33511960-7	2022	Bilirubin was negatively associated with body mass index, waist circumference, fasting insulin, HOMA-IR, NLR, PLR, uric acid, and positively associated with HDL-C. HDL-C and NLR were the independent predictor variables of total bilirubin.	Bilirubin	0-9	insulin	Homo sapiens	87-94
33394027-9	2021	This interaction between CYP1A1 and HO-1 also affected function, where the presence of CYP1A1 inhibited HO-1-mediated bilirubin formation by increasing the KmPOR HO-1 without affecting the Vmaxapp.	Bilirubin	118-127	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	25-31
33394027-9	2021	This interaction between CYP1A1 and HO-1 also affected function, where the presence of CYP1A1 inhibited HO-1-mediated bilirubin formation by increasing the KmPOR HO-1 without affecting the Vmaxapp.	Bilirubin	118-127	heme oxygenase 1	Homo sapiens	36-40
33394027-9	2021	This interaction between CYP1A1 and HO-1 also affected function, where the presence of CYP1A1 inhibited HO-1-mediated bilirubin formation by increasing the KmPOR HO-1 without affecting the Vmaxapp.	Bilirubin	118-127	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	87-93
33394027-9	2021	This interaction between CYP1A1 and HO-1 also affected function, where the presence of CYP1A1 inhibited HO-1-mediated bilirubin formation by increasing the KmPOR HO-1 without affecting the Vmaxapp.	Bilirubin	118-127	heme oxygenase 1	Homo sapiens	104-108
33394027-9	2021	This interaction between CYP1A1 and HO-1 also affected function, where the presence of CYP1A1 inhibited HO-1-mediated bilirubin formation by increasing the KmPOR HO-1 without affecting the Vmaxapp.	Bilirubin	118-127	heme oxygenase 1	Homo sapiens	104-108
33511960-8	2022	CONCLUSION: Among all the studied cardio-metabolic risk factors, HDL-C and NRL are the most closely associated variables with total bilirubin levels in obese adults.	Bilirubin	132-141	neural retina leucine zipper	Homo sapiens	75-78
33532784-2	2021	We show that SARS-CoV-2 spike binds biliverdin and bilirubin, the tetrapyrrole products of haem metabolism, with nanomolar affinity.	Bilirubin	51-60	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	24-29
33604208-1	2021	Crigler-Najjar syndrome is an inborn error of metabolism caused by a point mutation in one of the five exons of UGT1A1 gene, the product of which is responsible for elimination of bilirubin via bile.	Bilirubin	180-189	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	112-118
33452360-7	2021	Intrahepatic CD56Bright/CD16- natural killer (NK) cells comprised the only subset correlating with better liver function, i.e., lower bilirubin (p = 0.0002) and lower model for end stage of liver disease scores (p = 0.03).	Bilirubin	134-143	neural cell adhesion molecule 1	Homo sapiens	13-17
33438572-8	2021	RESULTS: The level of total bilirubin and bile acid in the NDR group was significantly higher than that in the PDR group, while the level of triglyceride, cholesterol and LDL-C were significantly lower than that in the PDR group (P<0.05).	Bilirubin	28-37	serine/threonine kinase 38	Homo sapiens	59-62
33452360-7	2021	Intrahepatic CD56Bright/CD16- natural killer (NK) cells comprised the only subset correlating with better liver function, i.e., lower bilirubin (p = 0.0002) and lower model for end stage of liver disease scores (p = 0.03).	Bilirubin	134-143	Fc gamma receptor IIIa	Homo sapiens	24-28
32666773-9	2021	After adjusting for age, sex, total bilirubin levels, and any stent placement, patients with a positive IOC had a significantly increased risk of PEP (odds ratio, 4.79; 95% confidence interval, 1.05-21.89; p<0.05).	Bilirubin	36-45	prolyl endopeptidase	Homo sapiens	146-149
33038216-8	2021	TR was not directly associated with higher 30-day mortality, but mediation analyses suggested an indirect association via preoperative elevated right atrial pressure and creatinine (P = 0.035) and bilirubin (P = 0.027) levels.	Bilirubin	197-206	coagulation factor II thrombin receptor	Homo sapiens	0-2
32865681-6	2021	CCl4-intoxicated rats showed elevated serum transaminases, ALP, gammaGT, bilirubin and pro-inflammatory cytokines, and decreased albumin.	Bilirubin	73-82	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
33154041-1	2021	UDP-glucuronosyltransferase 1A1 (UGT1A1) is the only transferase capable of conjugating serum bilirubin.	Bilirubin	94-103	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	0-31
33154041-1	2021	UDP-glucuronosyltransferase 1A1 (UGT1A1) is the only transferase capable of conjugating serum bilirubin.	Bilirubin	94-103	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	33-39
33154041-2	2021	However, temporal delay in the development of the UGT1A1 gene leads to an accumulation of serum bilirubin in newborn children.	Bilirubin	96-105	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	50-56
33154041-12	2021	Thus, new findings link an important role for CAR in intestinal UGT1A1 induction and its role in the intestinal maturation pathway Significance Statement Obeticholic acid (OCA) activates FXR target genes in both liver and intestinal tissues while inducing intestinal UGT1A1 which leads to the elimination of serum bilirubin in hUGT1 mice.	Bilirubin	314-323	nuclear receptor subfamily 1, group I, member 3	Mus musculus	46-49
33127565-5	2021	In hepatocyte-specific MANF knockout (HKO) mice, an extra increase in the liver/body ratio and serum ALT, AST, ALP, TBA, TBIL, and DBIL levels was detected after treatment with RFP.	Bilirubin	121-125	mesencephalic astrocyte-derived neurotrophic factor	Mus musculus	23-27
33154041-12	2021	Thus, new findings link an important role for CAR in intestinal UGT1A1 induction and its role in the intestinal maturation pathway Significance Statement Obeticholic acid (OCA) activates FXR target genes in both liver and intestinal tissues while inducing intestinal UGT1A1 which leads to the elimination of serum bilirubin in hUGT1 mice.	Bilirubin	314-323	nuclear receptor subfamily 1, group H, member 4	Mus musculus	187-190
33154041-13	2021	However, the induction of intestinal UGT1A1 and the elimination of bilirubin by OCA is driven entirely by activation of intestinal CAR, and not FXR.	Bilirubin	67-76	nuclear receptor subfamily 1, group I, member 3	Mus musculus	131-134
33154041-14	2021	The elimination of serum bilirubin is based on a CAR dependent mechanism that facilitates the acceleration of IEC differentiation, an event that underlies the induction of intestinal UGT1A1.	Bilirubin	25-34	nuclear receptor subfamily 1, group I, member 3	Mus musculus	49-52
33154041-14	2021	The elimination of serum bilirubin is based on a CAR dependent mechanism that facilitates the acceleration of IEC differentiation, an event that underlies the induction of intestinal UGT1A1.	Bilirubin	25-34	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	183-189
32183599-9	2021	The direct bilirubin level was higher in patients with genotype TT of rs4821116 (UBE2L3) than patients with genotype CT (p = .010).	Bilirubin	11-20	ubiquitin conjugating enzyme E2 L3	Homo sapiens	81-87
33402591-4	2021	Uridine diphosphate glucuronosyltransferase (UGT) gene polymorphisms such as UGT1A1*28/*6, age, performance status, serum lactate dehydrogenase levels, and bilirubin levels could be important considerations for predicting outcomes and tolerability with irinotecan-based regimens.	Bilirubin	156-165	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	0-43
33639073-6	2021	The present study identified a positive correlation between serum bilirubin, LDH, and hematological parameters such as Hb, WBC, and platelet count with STAG1 mutation.	Bilirubin	66-75	stromal antigen 1	Homo sapiens	152-157
33172613-1	2021	In this study, bacterial cellulose (BC)/soy protein isolate (SPI) composite membranes were prepared by in situ cross-linked polymerization, and used as efficient blood compatible adsorbents to remove bilirubin.	Bilirubin	200-209	chromogranin A	Homo sapiens	61-64
33172613-3	2021	The BC/SPI membranes with high SPI content showed high adsorption efficiency, short adsorption equilibrium time (2 h) and multiple adsorption effects on bilirubin.	Bilirubin	153-162	chromogranin A	Homo sapiens	7-10
33172613-3	2021	The BC/SPI membranes with high SPI content showed high adsorption efficiency, short adsorption equilibrium time (2 h) and multiple adsorption effects on bilirubin.	Bilirubin	153-162	chromogranin A	Homo sapiens	31-34
33386180-0	2021	Albumin-bilirubin score as a useful predictor of energy malnutrition in patients with hepatocellular carcinoma.	Bilirubin	8-17	albumin	Homo sapiens	0-7
32998136-11	2021	For example, the serum potassium level in the FMO3 E308G genotype group was significantly lower than that in the WT group (p = 0.028), the abnormal level of total bilirubin in the FMO3 E308G genotype group was significantly higher than that in the WT group (p = 0.049), and the aspartate aminotransferase level in the E308G group was significantly higher than that in the WT group (p = 0.05).	Bilirubin	163-172	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	46-50
32998136-11	2021	For example, the serum potassium level in the FMO3 E308G genotype group was significantly lower than that in the WT group (p = 0.028), the abnormal level of total bilirubin in the FMO3 E308G genotype group was significantly higher than that in the WT group (p = 0.049), and the aspartate aminotransferase level in the E308G group was significantly higher than that in the WT group (p = 0.05).	Bilirubin	163-172	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	180-184
33184238-4	2020	Heme oxygenase-1 (HO-1) is a cytoprotective, inducible enzyme that degrades toxic free heme released from destabilized heme proteins and, during this process, releases beneficial by-products such as carbon monoxide and biliverdin/bilirubin and promotes ferritin synthesis.	Bilirubin	230-239	heme oxygenase 1	Homo sapiens	0-16
33184238-4	2020	Heme oxygenase-1 (HO-1) is a cytoprotective, inducible enzyme that degrades toxic free heme released from destabilized heme proteins and, during this process, releases beneficial by-products such as carbon monoxide and biliverdin/bilirubin and promotes ferritin synthesis.	Bilirubin	230-239	heme oxygenase 1	Homo sapiens	18-22
33246172-6	2021	Additionally, SGLT2 inhibitors showed a significant increase in bilirubin levels (WMD: 0.64 U/L, 95% CI: 0.27, 1.00, I2 = 53%, p < 0.0006.	Bilirubin	64-73	solute carrier family 5 member 2	Homo sapiens	14-19
33386180-3	2021	This study aimed to investigate the relationship between the albumin-bilirubin (ALBI) score and npRQ in patients with HCC.	Bilirubin	69-78	albumin	Homo sapiens	61-68
33406546-6	2020	Abnormal alanine aminotransferase (ALT) and alanine aminotransferase (AST) are consistent with elevated bilirubin.	Bilirubin	104-113	glutamic--pyruvic transaminase	Homo sapiens	9-33
33406546-6	2020	Abnormal alanine aminotransferase (ALT) and alanine aminotransferase (AST) are consistent with elevated bilirubin.	Bilirubin	104-113	glutamic--pyruvic transaminase	Homo sapiens	44-68
33406546-6	2020	Abnormal alanine aminotransferase (ALT) and alanine aminotransferase (AST) are consistent with elevated bilirubin.	Bilirubin	104-113	solute carrier family 17 member 5	Homo sapiens	70-73
33348603-4	2020	A significant correlation existed between serum ALP and direct bilirubin (DB), expressed by the regression equation: M-ALP (IU/L) = 302.1 + 96.9 (DB (mg/dL)).	Bilirubin	63-72	alkaline phosphatase, placental	Homo sapiens	48-51
33307711-13	2021	Anti-KLHL12 and anti-HK1-positive patients had higher serum levels of ALP, gamma-GT and bilirubin, with statistical differences (P<0.01) compared with anti-KLHL12 or anti-HK1-negative patients.	Bilirubin	88-97	kelch like family member 12	Homo sapiens	5-11
33348603-4	2020	A significant correlation existed between serum ALP and direct bilirubin (DB), expressed by the regression equation: M-ALP (IU/L) = 302.1 + 96.9 (DB (mg/dL)).	Bilirubin	63-72	alkaline phosphatase, placental	Homo sapiens	117-122
33390979-3	2020	The bilirubin nanoparticles significantly reduced hepatic fat, triglyceride accumulation, de novo lipogenesis, and serum levels of liver dysfunction marker aspartate transaminase and ApoB100 containing very-low-density lipoprotein.	Bilirubin	4-13	apolipoprotein B	Mus musculus	183-190
33390979-4	2020	The bilirubin nanoparticles improved liver function and activated the hepatic beta-oxidation pathway by increasing PPARalpha and acyl-coenzyme A oxidase 1.	Bilirubin	4-13	peroxisome proliferator activated receptor alpha	Mus musculus	115-124
33307711-13	2021	Anti-KLHL12 and anti-HK1-positive patients had higher serum levels of ALP, gamma-GT and bilirubin, with statistical differences (P<0.01) compared with anti-KLHL12 or anti-HK1-negative patients.	Bilirubin	88-97	hexokinase 1	Homo sapiens	21-24
33292156-6	2021	The molecular docking of bilirubin on CDKs (Cyclin-dependent kinases 2, 4, and 6) and pro-apoptotic factors Bad, Bak, Bax, Bid, Bik, and Bim were done by Autodock software version 2.	Bilirubin	25-34	cyclin dependent kinase 2	Homo sapiens	38-42
33275767-6	2020	Median bilirubin levels also increased across the groups, being highest (239 mmol/L; interquartile range 96-390 mmol/L) in G6PD c.202T homo/hemizygotes.	Bilirubin	7-16	glucose-6-phosphate dehydrogenase	Homo sapiens	123-127
33372599-14	2020	Clinically, serum RRM2 was significantly associated with serum alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma glutamyl transpeptidase (gamma-GT), albumin (ALB) and total bilirubin.	Bilirubin	280-289	ribonucleotide reductase regulatory subunit M2	Homo sapiens	18-22
33292156-6	2021	The molecular docking of bilirubin on CDKs (Cyclin-dependent kinases 2, 4, and 6) and pro-apoptotic factors Bad, Bak, Bax, Bid, Bik, and Bim were done by Autodock software version 2.	Bilirubin	25-34	cyclin dependent kinase 2	Homo sapiens	44-80
33292156-6	2021	The molecular docking of bilirubin on CDKs (Cyclin-dependent kinases 2, 4, and 6) and pro-apoptotic factors Bad, Bak, Bax, Bid, Bik, and Bim were done by Autodock software version 2.	Bilirubin	25-34	BCL2 antagonist/killer 1	Homo sapiens	113-116
33292156-6	2021	The molecular docking of bilirubin on CDKs (Cyclin-dependent kinases 2, 4, and 6) and pro-apoptotic factors Bad, Bak, Bax, Bid, Bik, and Bim were done by Autodock software version 2.	Bilirubin	25-34	BCL2 associated X, apoptosis regulator	Homo sapiens	118-121
33292156-6	2021	The molecular docking of bilirubin on CDKs (Cyclin-dependent kinases 2, 4, and 6) and pro-apoptotic factors Bad, Bak, Bax, Bid, Bik, and Bim were done by Autodock software version 2.	Bilirubin	25-34	BH3 interacting domain death agonist	Homo sapiens	123-126
33292156-6	2021	The molecular docking of bilirubin on CDKs (Cyclin-dependent kinases 2, 4, and 6) and pro-apoptotic factors Bad, Bak, Bax, Bid, Bik, and Bim were done by Autodock software version 2.	Bilirubin	25-34	BCL2 like 11	Homo sapiens	137-140
33263631-1	2020	OBJECTIVES: The present study was designed to explore the roles of inflammatory cytokines interleukin-1beta (IL-1beta) and Tumor growth factor-beta (TGF-beta) in the diagnosis and treatment of neonate bilirubin encephalopathy (BE).	Bilirubin	201-210	interleukin 1 beta	Homo sapiens	90-107
33113421-12	2020	Serological tests showed that albumin-bilirubin (ALBI) scores and models for end-stage liver disease (MELD) were lower.	Bilirubin	38-47	albumin	Rattus norvegicus	30-37
32896803-10	2020	CONCLUSIONS: These results suggest that IL-6 trajectories of CAP patients are associated with age and run parallel to bilirubin levels.	Bilirubin	118-127	interleukin 6	Homo sapiens	40-44
32885557-9	2020	Gas6 and Axl were significantly correlated with aspartate aminotransferase, bilirubin, albumin, and platelets.	Bilirubin	76-85	growth arrest specific 6	Homo sapiens	0-4
32885557-9	2020	Gas6 and Axl were significantly correlated with aspartate aminotransferase, bilirubin, albumin, and platelets.	Bilirubin	76-85	AXL receptor tyrosine kinase	Homo sapiens	9-12
33252413-11	2021	Bilirubin and albumin independently predicted inadequate BR; advanced disease stage and inadequate BR independently predicted complications.	Bilirubin	0-9	chromosome 12 open reading frame 73	Homo sapiens	57-59
33263631-1	2020	OBJECTIVES: The present study was designed to explore the roles of inflammatory cytokines interleukin-1beta (IL-1beta) and Tumor growth factor-beta (TGF-beta) in the diagnosis and treatment of neonate bilirubin encephalopathy (BE).	Bilirubin	201-210	transforming growth factor alpha	Homo sapiens	149-157
33263631-4	2020	Moreover, the correlation between the level of bilirubin and serum expression of IL-1beta or TGF-beta in BE patients was analyzed.	Bilirubin	47-56	interleukin 1 alpha	Homo sapiens	81-89
33263631-4	2020	Moreover, the correlation between the level of bilirubin and serum expression of IL-1beta or TGF-beta in BE patients was analyzed.	Bilirubin	47-56	transforming growth factor alpha	Homo sapiens	93-101
33263631-6	2020	RESULTS: IL-1beta and TGF-beta levels were higher in the serum of BE patients than those in non-BE patients, and the expression of either IL-1beta or TGF-beta showed a strong positive correlation with the serum expression of bilirubin in BE patients.	Bilirubin	225-234	interleukin 1 alpha	Homo sapiens	138-146
33263631-6	2020	RESULTS: IL-1beta and TGF-beta levels were higher in the serum of BE patients than those in non-BE patients, and the expression of either IL-1beta or TGF-beta showed a strong positive correlation with the serum expression of bilirubin in BE patients.	Bilirubin	225-234	transforming growth factor alpha	Homo sapiens	150-158
33228260-1	2020	Heme oxygenase-1 (HO-1) is an inducible stress protein that catalyzes the oxidative conversion of heme to carbon monoxide (CO), iron, and biliverdin (BV), the latter of which is converted to bilirubin (BR) by biliverdin reductase.	Bilirubin	191-200	heme oxygenase 1	Homo sapiens	0-16
33238962-7	2020	Serum HO-1 correlated with serum total bilirubin (R = 0.454, P <  0.001) and serum LDH (R = 0.500, P <  0.001).	Bilirubin	39-48	heme oxygenase 1	Homo sapiens	6-10
33228260-1	2020	Heme oxygenase-1 (HO-1) is an inducible stress protein that catalyzes the oxidative conversion of heme to carbon monoxide (CO), iron, and biliverdin (BV), the latter of which is converted to bilirubin (BR) by biliverdin reductase.	Bilirubin	191-200	heme oxygenase 1	Homo sapiens	18-22
33228260-1	2020	Heme oxygenase-1 (HO-1) is an inducible stress protein that catalyzes the oxidative conversion of heme to carbon monoxide (CO), iron, and biliverdin (BV), the latter of which is converted to bilirubin (BR) by biliverdin reductase.	Bilirubin	191-200	chromosome 12 open reading frame 73	Homo sapiens	202-204
33392490-1	2021	Background & Aims: The albumin-bilirubin (ALBI) grade/score is derived from a validated nomogram to objectively assess prognosis and liver function in patients with hepatocellular carcinoma (HCC).	Bilirubin	31-40	albumin	Homo sapiens	23-30
33147210-5	2020	Cdk1Liv-/- mice display classical markers of liver damage two weeks after birth, including elevated ALT, ALP, and bilirubin levels, despite the lack of exogenous liver injury.	Bilirubin	114-123	cyclin-dependent kinase 1	Mus musculus	0-4
33169293-7	2021	Serum biochemical tests (Bilirubin, ALT and ALP) and sandwich ELISA results of EGF and HGF showed marked increase in CCl4 treated mice serum as compared to normal mice serum.	Bilirubin	25-34	chemokine (C-C motif) ligand 4	Mus musculus	117-121
33171992-4	2020	By direct and indirect activation, CAR is implicated in hepatic detoxification of xenobiotics, environmental contaminants, and endogenous molecules (bilirubin, bile acids).	Bilirubin	149-158	nuclear receptor subfamily 1 group I member 3	Homo sapiens	35-38
33148149-10	2021	Betain attenuates mechanism of MIF-mediated effects in TAA-induced liver injury, reducing transaminases, -glutamyltranspeptidase, bilirubin, MDA, AOPP, TOS, CRP, IL-6, IFN-g and increasing thiols.	Bilirubin	130-139	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	31-34
32800317-9	2020	In multivariate analysis, serum albumin was the sole independent predictor of hospital death (P<0.01), after adjusting for malnutrition (prealbumin P=ns), inflammation (C-reactive protein P=ns) and liver dysfunction (total bilirubin P=ns).	Bilirubin	223-232	albumin	Homo sapiens	32-39
32436265-5	2020	Children with SLC4A1-HS had the mildest phenotype, showing the highest haemoglobin (P < 0 001), lowest reticulocyte counts (P < 0 001) and lowest unconjugated bilirubin levels (P = 0 006), and none required splenectomy in childhood (P < 0 001).	Bilirubin	159-168	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	14-20
33093374-8	2020	The serum direct bilirubin level in NTCP-deficient patients was significantly higher than age- and sex-matched controls even after the neonatal cholestasis stage (2.85 +- 1.50 vs 1.49 +- 0.70 mumol/L, P = 0.00008).	Bilirubin	17-26	solute carrier family 10 member 1	Homo sapiens	36-40
33222086-3	2020	Bilirubin, being an endogenous antioxidant, is probably involved in protection of the retina and lens from LPO processes that intensively develop in retinal neurons and lens fibers.	Bilirubin	0-9	lactoperoxidase	Homo sapiens	107-110
32305248-13	2020	Anti-gp210 antibody positivity; AMA negativity; high ALP, TBIL and globulin levels; and a severe degree of fibrosis at baseline were associated with a poor prognosis.	Bilirubin	58-62	nucleoporin 210	Homo sapiens	5-10
32973940-1	2020	Gilbert syndrome (GS) is a hereditary unconjugated hyperbilirubinemia that results from mutations in the bilirubin uridine diphosphate-glucuronosyltransferase (UGT1A1) gene.	Bilirubin	56-65	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	160-166
32761495-6	2020	The level of ATIII was significantly negatively correlated with the levels of neutrophils, ferritin, LDH, total bilirubin, IL2R, IL6 and IL8 (p < 0.05).	Bilirubin	112-121	serpin family C member 1	Homo sapiens	13-18
32737884-9	2020	Grade 1 total bilirubin elevation was associated with the homozygous UGT1A1*6 mutation (P = 0.027) or any UGT1A1*6 variants (P = 0.047).	Bilirubin	14-23	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	69-75
32737884-9	2020	Grade 1 total bilirubin elevation was associated with the homozygous UGT1A1*6 mutation (P = 0.027) or any UGT1A1*6 variants (P = 0.047).	Bilirubin	14-23	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	106-112
32882667-13	2020	RESULTS: The group of niclosamide-and-CCl4-treated rats showed a significant decrease in total bilirubin, ALT and AST, beta-catenin, l-hydroxyproline, l-glutaminase activity, and gene expression of TGF-beta1 and Dvl2.	Bilirubin	95-104	C-C motif chemokine ligand 4	Rattus norvegicus	38-42
33143041-3	2020	METHODS: Hepatic (HepG2), heart endothelial (H5V), kidney tubular (HK2) and neuronal (SH-SY5Y) cell lines were exposed to increasing concentration of bilirubin.	Bilirubin	150-159	hexokinase 2	Homo sapiens	67-70
33178828-7	2020	The circulating GDF15 levels strongly correlated with weight changes (r = -0.541, p = 0.0138), albumin (r = -0.775, p < 0.0001), direct bilirubin (r = -0.786, p < 0.0001), total bile acids (r = 0.585, p = 0.007), and C-reactive protein (r = 0.718, p = 0.0005).	Bilirubin	136-145	growth differentiation factor 15	Homo sapiens	16-21
32860873-5	2020	In context with ROS, HO-1 expression has been associated with antioxidant defense related to the heme-metabolite redox pair biliverdin/bilirubin.	Bilirubin	135-144	heme oxygenase 1	Homo sapiens	21-25
33149620-0	2020	Bilirubin Can Be Used as a Prognostic Factor for Lung Adenocarcinoma Patients with EGFR Mutations.	Bilirubin	0-9	epidermal growth factor receptor	Homo sapiens	83-87
33149620-3	2020	This study aimed to investigate the prediction of pretreatment circulating bilirubin for PFS in lung adenocarcinoma (LAC) patients who underwent EGFR-TKIs targeted therapy.	Bilirubin	75-84	epidermal growth factor receptor	Homo sapiens	145-149
33149620-11	2020	Conclusion: This study confirms that bilirubin can predict the prognosis of LAC patients who had undergone EGFR-TKIs targeted therapy.	Bilirubin	37-46	epidermal growth factor receptor	Homo sapiens	107-111
33082429-0	2020	The albumin-bilirubin score as a predictor of outcomes in Japanese patients with PBC: an analysis using time-dependent ROC.	Bilirubin	12-21	albumin	Homo sapiens	4-11
33082429-1	2020	The albumin-bilirubin (ALBI) score is calculated using only serum albumin and bilirubin levels, and was developed as a simple method to assess hepatic function.	Bilirubin	12-21	albumin	Homo sapiens	4-11
33082429-1	2020	The albumin-bilirubin (ALBI) score is calculated using only serum albumin and bilirubin levels, and was developed as a simple method to assess hepatic function.	Bilirubin	12-21	albumin	Homo sapiens	66-73
33082429-1	2020	The albumin-bilirubin (ALBI) score is calculated using only serum albumin and bilirubin levels, and was developed as a simple method to assess hepatic function.	Bilirubin	78-87	albumin	Homo sapiens	4-11
33074470-8	2021	In multivariable linear regression, bilirubin, WBC, and platelet count remained negatively correlated with myostatin in AH.	Bilirubin	36-45	myostatin	Homo sapiens	107-116
33074470-11	2021	CONCLUSIONS: Myostatin levels are significantly lower in AH compared to HD and are negatively correlated with total bilirubin, WBC, and platelet count.	Bilirubin	116-125	myostatin	Homo sapiens	13-22
33116850-8	2020	The area under the receiver operating characteristic curves in predicting 5-year OS and RFS using the albumin-to-globulin ratio were 0.68 and 0.67, respectively, which were significantly higher than albumin (0.60 and 0.59), globulin (0.56 and 0.57), Child-Pugh grading (0.61 and 0.60), Model for End-Stage Liver Disease Score (0.59 and 0.58), and Albumin-Bilirubin grading (0.64 and 0.63).	Bilirubin	355-364	albumin	Homo sapiens	102-109
33178739-0	2020	Albumin-bilirubin score: an additional tool for the management of patients with hepatocellular carcinoma.	Bilirubin	8-17	albumin	Homo sapiens	0-7
32128811-5	2020	We found that BRUP-1 up-regulated the expression level of heme oxygenase-1 (HO-1), one of the rate-limiting enzyme of bilirubin production via nuclear factor erythroid 2-related factor 2 (Nrf2) activation.	Bilirubin	118-127	heme oxygenase 1	Homo sapiens	58-74
32128811-5	2020	We found that BRUP-1 up-regulated the expression level of heme oxygenase-1 (HO-1), one of the rate-limiting enzyme of bilirubin production via nuclear factor erythroid 2-related factor 2 (Nrf2) activation.	Bilirubin	118-127	heme oxygenase 1	Homo sapiens	76-80
32128811-5	2020	We found that BRUP-1 up-regulated the expression level of heme oxygenase-1 (HO-1), one of the rate-limiting enzyme of bilirubin production via nuclear factor erythroid 2-related factor 2 (Nrf2) activation.	Bilirubin	118-127	NFE2 like bZIP transcription factor 2	Homo sapiens	188-192
33062074-5	2020	The minor allele (T) of TGFBR3 rs7526590 was associated with increased red cell distribution width, PDW, alkaline phosphatase, aspartate aminotransferase, total and indirect bilirubin, and lactate dehydrogenase levels, as well as lower ferritin levels and the occurrence of leg ulcers.	Bilirubin	174-183	transforming growth factor beta receptor 3	Homo sapiens	24-30
32974842-2	2020	Clinical manifestations of PKD reflect the symptoms and complications of the chronic hemolysis, including anemia, jaundice, bilirubin gallstones due to hyperbilirubinemia, splenomegaly and iron overload.	Bilirubin	124-133	protein kinase D1	Homo sapiens	27-30
33134292-8	2020	Both carbon monoxide (CORM-2, 50 nM) and bilirubin (50 nM) significantly prevented ROS production in Abeta-treated neurons and favored both the slowdown of the growth rate of Abeta oligomers and the decrease in oligomer/fibril final size.	Bilirubin	41-50	amyloid beta precursor protein	Homo sapiens	101-106
33134292-8	2020	Both carbon monoxide (CORM-2, 50 nM) and bilirubin (50 nM) significantly prevented ROS production in Abeta-treated neurons and favored both the slowdown of the growth rate of Abeta oligomers and the decrease in oligomer/fibril final size.	Bilirubin	41-50	amyloid beta precursor protein	Homo sapiens	175-180
32971746-1	2020	Heme oxygenase-1 is induced by many cellular stressors and catalyzes the breakdown of heme to generate carbon monoxide and bilirubin, which confer cytoprotection.	Bilirubin	123-132	heme oxygenase 1	Homo sapiens	0-16
32961782-0	2020	Rats Genetically Selected for High Aerobic Exercise Capacity Have Elevated Plasma Bilirubin by Upregulation of Hepatic Biliverdin Reductase-A (BVRA) and Suppression of UGT1A1.	Bilirubin	82-91	biliverdin reductase A	Rattus norvegicus	119-141
32961782-0	2020	Rats Genetically Selected for High Aerobic Exercise Capacity Have Elevated Plasma Bilirubin by Upregulation of Hepatic Biliverdin Reductase-A (BVRA) and Suppression of UGT1A1.	Bilirubin	82-91	biliverdin reductase A	Rattus norvegicus	143-147
32961782-3	2020	The HCR rats, compared to the LCR, exhibited significantly higher levels of plasma bilirubin and the hepatic enzyme that produces it, biliverdin reductase-A (BVRA).	Bilirubin	83-92	biliverdin reductase A	Rattus norvegicus	158-162
32961782-4	2020	The HCR also had reduced expression of the glucuronyl hepatic enzyme UGT1A1, which lowers plasma bilirubin.	Bilirubin	97-106	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	69-75
32961782-5	2020	Recently, bilirubin has been shown to activate the peroxisome proliferator-activated receptor-alpha (PPARalpha), a ligand-induced transcription factor, and the higher bilirubin HCR rats had significantly increased PPARalpha-target genes Fgf21, Abcd3, and Gys2.	Bilirubin	10-19	peroxisome proliferator activated receptor alpha	Rattus norvegicus	51-99
32961782-5	2020	Recently, bilirubin has been shown to activate the peroxisome proliferator-activated receptor-alpha (PPARalpha), a ligand-induced transcription factor, and the higher bilirubin HCR rats had significantly increased PPARalpha-target genes Fgf21, Abcd3, and Gys2.	Bilirubin	10-19	peroxisome proliferator activated receptor alpha	Rattus norvegicus	101-110
32961782-5	2020	Recently, bilirubin has been shown to activate the peroxisome proliferator-activated receptor-alpha (PPARalpha), a ligand-induced transcription factor, and the higher bilirubin HCR rats had significantly increased PPARalpha-target genes Fgf21, Abcd3, and Gys2.	Bilirubin	10-19	peroxisome proliferator activated receptor alpha	Rattus norvegicus	214-223
32961782-5	2020	Recently, bilirubin has been shown to activate the peroxisome proliferator-activated receptor-alpha (PPARalpha), a ligand-induced transcription factor, and the higher bilirubin HCR rats had significantly increased PPARalpha-target genes Fgf21, Abcd3, and Gys2.	Bilirubin	10-19	fibroblast growth factor 21	Rattus norvegicus	237-242
32961782-5	2020	Recently, bilirubin has been shown to activate the peroxisome proliferator-activated receptor-alpha (PPARalpha), a ligand-induced transcription factor, and the higher bilirubin HCR rats had significantly increased PPARalpha-target genes Fgf21, Abcd3, and Gys2.	Bilirubin	10-19	ATP binding cassette subfamily D member 3	Rattus norvegicus	244-249
32961782-5	2020	Recently, bilirubin has been shown to activate the peroxisome proliferator-activated receptor-alpha (PPARalpha), a ligand-induced transcription factor, and the higher bilirubin HCR rats had significantly increased PPARalpha-target genes Fgf21, Abcd3, and Gys2.	Bilirubin	10-19	glycogen synthase 2	Rattus norvegicus	255-259
32961782-5	2020	Recently, bilirubin has been shown to activate the peroxisome proliferator-activated receptor-alpha (PPARalpha), a ligand-induced transcription factor, and the higher bilirubin HCR rats had significantly increased PPARalpha-target genes Fgf21, Abcd3, and Gys2.	Bilirubin	167-176	peroxisome proliferator activated receptor alpha	Rattus norvegicus	214-223
32961782-5	2020	Recently, bilirubin has been shown to activate the peroxisome proliferator-activated receptor-alpha (PPARalpha), a ligand-induced transcription factor, and the higher bilirubin HCR rats had significantly increased PPARalpha-target genes Fgf21, Abcd3, and Gys2.	Bilirubin	167-176	fibroblast growth factor 21	Rattus norvegicus	237-242
32961782-5	2020	Recently, bilirubin has been shown to activate the peroxisome proliferator-activated receptor-alpha (PPARalpha), a ligand-induced transcription factor, and the higher bilirubin HCR rats had significantly increased PPARalpha-target genes Fgf21, Abcd3, and Gys2.	Bilirubin	167-176	ATP binding cassette subfamily D member 3	Rattus norvegicus	244-249
32961782-5	2020	Recently, bilirubin has been shown to activate the peroxisome proliferator-activated receptor-alpha (PPARalpha), a ligand-induced transcription factor, and the higher bilirubin HCR rats had significantly increased PPARalpha-target genes Fgf21, Abcd3, and Gys2.	Bilirubin	167-176	glycogen synthase 2	Rattus norvegicus	255-259
32749754-11	2020	Moreover, bilirubin down-regulated RUNX2 and up-regulated RANKL gene expression in bone tissue, MLO-Y4 and MLO-A5 cells, and LCA up-regulated RANKL expression in bone tissue.	Bilirubin	10-19	runt related transcription factor 2	Mus musculus	35-40
32749754-11	2020	Moreover, bilirubin down-regulated RUNX2 and up-regulated RANKL gene expression in bone tissue, MLO-Y4 and MLO-A5 cells, and LCA up-regulated RANKL expression in bone tissue.	Bilirubin	10-19	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	58-63
32878631-9	2020	In the MR analysis of the main UGT1A1 SNP (rs6431625), genetically predicted higher levels of total bilirubin were associated with a 7% increase in CRC risk in men (OR = 1.07 (1.02-1.12); P = 0.006; per 1-SD increment of total bilirubin), while there was no association in women (OR = 1.01 (0.96-1.06); P = 0.73).	Bilirubin	100-109	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	31-37
32749754-12	2020	UDCA 100 muM increased the gene expression of all these genes in bone tissue and MLO-Y4 cells and neutralized the decreased RUNX2 expression induced by bilirubin.	Bilirubin	152-161	runt related transcription factor 2	Mus musculus	124-129
32893257-9	2021	In the Fontan group, the liver native T1 value was significantly correlated with age, gamma-glutamyltransferase, model for end-stage liver disease XI score, and albumin-bilirubin score (P = 0.01, 0.01, 0.044, 0.001).	Bilirubin	169-178	albumin	Homo sapiens	161-168
32899732-1	2020	Heme oxygenase-1 (HO-1) catalyzes the degradation of heme into carbon monoxide (CO), iron, and biliverdin, which is rapidly metabolized to bilirubin.	Bilirubin	139-148	heme oxygenase 1	Homo sapiens	0-16
32899732-1	2020	Heme oxygenase-1 (HO-1) catalyzes the degradation of heme into carbon monoxide (CO), iron, and biliverdin, which is rapidly metabolized to bilirubin.	Bilirubin	139-148	heme oxygenase 1	Homo sapiens	18-22
32899732-4	2020	The vasoprotection evoked by HO-1 is largely ascribed to the generation of CO and/or the bile pigments, biliverdin and bilirubin, which exert potent antioxidant and anti-inflammatory effects.	Bilirubin	119-128	heme oxygenase 1	Homo sapiens	29-33
32899732-6	2020	Several therapeutic strategies are currently being pursued that may allow for the targeting of HO-1 in arterial remodeling in various pathologies, including the use of gene delivery approaches, the development of novel inducers of the enzyme, and the administration of unique formulations of CO and bilirubin.	Bilirubin	299-308	heme oxygenase 1	Homo sapiens	95-99
33013289-0	2020	Abnormal Serum Bilirubin/Albumin Concentrations in Dementia Patients With Abeta Deposition and the Benefit of Intravenous Albumin Infusion for Alzheimer"s Disease Treatment.	Bilirubin	15-24	amyloid beta precursor protein	Homo sapiens	74-79
33013289-1	2020	Background: Our previous study in animal models revealed that bilirubin could induce Abeta formation and deposition.	Bilirubin	62-71	amyloid beta precursor protein	Homo sapiens	85-90
32787357-9	2020	Lp-PLA2 activity was correlated with total bilirubin (TB) at specific time points (P<0.05 for all).	Bilirubin	43-52	phospholipase A2 group VII	Homo sapiens	0-7
33013289-2	2020	Bilirubin may be important in neurodegenerative dementia with Abeta deposition.	Bilirubin	0-9	amyloid beta precursor protein	Homo sapiens	62-67
33013289-4	2020	Objectives: The objectives of this study were to examine the change in the serum bilirubin and albumin concentrations of dementia patients with Abeta deposition, and to determine the effects of intravenous administration of albumin in the treatment of AD.	Bilirubin	81-90	amyloid beta precursor protein	Homo sapiens	144-149
33013289-5	2020	Methods: Bilirubin and albumin concentrations in dementia patients with Abeta deposition were examined.	Bilirubin	9-18	amyloid beta precursor protein	Homo sapiens	72-77
33013289-8	2020	Results: Significantly higher indirect bilirubin (IBIL) concentrations, lower albumin concentrations, and higher ratio of IBIL to albumin (IBIL/ALB) were observed in dementia patients with Abeta deposition, including AD, dementia with Lewy bodies, and general paresis of insane.	Bilirubin	39-48	amyloid beta precursor protein	Homo sapiens	189-194
33145264-0	2020	Changes in prognostic factors for patients with hepatocellular carcinoma underwent transarterial chemoembolization with the transition of the time: Child-Pugh class, Albumin-Bilirubin grade, and then.	Bilirubin	174-183	albumin	Homo sapiens	166-173
32579060-0	2020	Bilirubin binding affects the structure and function of alpha-2-macroglobulin.	Bilirubin	0-9	alpha-2-macroglobulin	Homo sapiens	56-77
32579060-4	2020	In the present study, we have investigated the interaction of photo-illuminated bilirubin with serum alpha2M using various biophysical and thermodynamic techniques.	Bilirubin	80-89	alpha-2-macroglobulin	Homo sapiens	101-108
32579060-5	2020	The binding of bilirubin to alpha2M leads to various functional and structural changes in alpha2M protein.	Bilirubin	15-24	alpha-2-macroglobulin	Homo sapiens	28-35
32579060-5	2020	The binding of bilirubin to alpha2M leads to various functional and structural changes in alpha2M protein.	Bilirubin	15-24	alpha-2-macroglobulin	Homo sapiens	90-97
32579060-6	2020	The result of ultraviolet (UV) and fluorescence spectroscopy suggests that binding of bilirubin to alpha2M induces a conformational change in the secondary structure of protein which was corroborated by circular dichroism (CD) and Fourier-transform infrared spectroscopy (FT-IR).	Bilirubin	86-95	alpha-2-macroglobulin	Homo sapiens	99-106
32579060-8	2020	The thermodynamic parameters of bilirubin-alpha2M binding indicate that the binding is exothermic, and the reaction spontaneous.	Bilirubin	32-41	alpha-2-macroglobulin	Homo sapiens	42-49
32579060-9	2020	Our studies show that binding of bilirubin with alpha2M in the presence of light induces structural and functional modifications in the protein.	Bilirubin	33-42	alpha-2-macroglobulin	Homo sapiens	48-55
32787357-9	2020	Lp-PLA2 activity was correlated with total bilirubin (TB) at specific time points (P<0.05 for all).	Bilirubin	54-56	phospholipase A2 group VII	Homo sapiens	0-7
31830562-4	2020	Activation of Nrf2 results in the synthesis of heme oxygenase-1 (HO-1) leading to the formation of a number of bioactive metabolites, mainly CO, biliverdin and bilirubin.	Bilirubin	160-169	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
32618701-12	2020	Angiopoietin-2 was associated with hemolysis (lactate dehydrogenase, total bilirubin) and inflammation (tumor necrosis factor-alpha, interleukin-10).	Bilirubin	75-84	angiopoietin 2	Homo sapiens	0-14
31830562-4	2020	Activation of Nrf2 results in the synthesis of heme oxygenase-1 (HO-1) leading to the formation of a number of bioactive metabolites, mainly CO, biliverdin and bilirubin.	Bilirubin	160-169	heme oxygenase 1	Homo sapiens	47-63
31830562-4	2020	Activation of Nrf2 results in the synthesis of heme oxygenase-1 (HO-1) leading to the formation of a number of bioactive metabolites, mainly CO, biliverdin and bilirubin.	Bilirubin	160-169	heme oxygenase 1	Homo sapiens	65-69
32506707-1	2020	BACKGROUND/PURPOSE: We investigated whether the daily level of total bilirubin in the bile (LTB) excreted from the future remnant liver (FRL) can predict post-hepatectomy liver failure (PHLF) in patients with obstructive jaundice undergoing hepatectomy.	Bilirubin	69-78	lymphotoxin beta	Homo sapiens	92-95
32347305-11	2020	OUTCOMES: HO-1 exerts some protective effects on the placentation, probably by a combination of factors, including its interrelation with the PGC-1alpha/PPAR pathway and the sFlt1/PlGF balance, and through its primary metabolites, notably carbon monoxide and bilirubin.	Bilirubin	259-268	heme oxygenase 1	Homo sapiens	10-14
32506707-3	2020	The LTB from the FRL (mg/day) was calculated as the volume of the bile (dL) per day multiplied by the density of total bilirubin in the bile (mg/dL).	Bilirubin	119-128	lymphotoxin beta	Homo sapiens	4-7
32600880-7	2020	This was found for a Model for End-Stage Liver Disease score <=9 versus >9 (P = .04), combination of bilirubin and cholinesterases levels score <=2 versus >2 (P = .02), albumin to bilirubin grades (P = .03), and Humanitas score <=6 versus >6 (P = .03).	Bilirubin	180-189	albumin	Homo sapiens	169-176
32740186-10	2020	In children with sepsis-induced organ dysfunction, angiopoietin-2/-1 ratios correlated with oxygenation indices and serum levels of creatinine and bilirubin.	Bilirubin	147-156	angiopoietin 2	Homo sapiens	51-68
32884419-6	2020	Exposure of CCl4 resulted in elevation of serum biomarkers of liver damage (aspartate transaminase, alanine aminotransferase, gamma-glutamyl transferase and alkaline phosphatase), bilirubin and dysregulation of serum lipid profile (cholesterol and triglycerides).	Bilirubin	180-189	C-C motif chemokine ligand 4	Rattus norvegicus	12-16
32908636-6	2020	HO-1 activity leads to production of carbon monoxide (CO), free iron ion, and biliverdin; the latter is promptly reduced to bilirubin.	Bilirubin	124-133	heme oxygenase 1	Homo sapiens	0-4
32933638-9	2020	Compared with the control group, the bilirubin group had a significantly higher positive rate of small-molecule EtBr passing through the cell membrane (P<0.001), while there was no significant difference in the pass rate of large-molecule EthD2 between groups (P>0.05).	Bilirubin	37-46	endothelin receptor type B	Rattus norvegicus	112-116
32933638-10	2020	The expression of activated Caspase-1 significantly increased at 0.5 hour after bilirubin stimulation (P<0.05), and that of activated GSDMD significantly increased at 6 hours after bilirubin stimulation (P<0.05).	Bilirubin	181-190	gasdermin D	Rattus norvegicus	134-139
32933638-11	2020	The release of IL-1beta significantly increased at 6 hours after bilirubin stimulation and reached the peak at 24 hours (P<0.001).	Bilirubin	65-74	interleukin 1 alpha	Rattus norvegicus	15-23
32933638-12	2020	Compared with the bilirubin group, the VX-765+bilirubin group had a significant increase in cell viability (P<0.05) and significant reductions in the expression of activated GSDMD, the pass rate of EtBr, and the release of LDH and IL-1beta (P<0.05).	Bilirubin	46-55	gasdermin D	Rattus norvegicus	174-179
32933638-12	2020	Compared with the bilirubin group, the VX-765+bilirubin group had a significant increase in cell viability (P<0.05) and significant reductions in the expression of activated GSDMD, the pass rate of EtBr, and the release of LDH and IL-1beta (P<0.05).	Bilirubin	46-55	endothelin receptor type B	Rattus norvegicus	198-202
32933638-12	2020	Compared with the bilirubin group, the VX-765+bilirubin group had a significant increase in cell viability (P<0.05) and significant reductions in the expression of activated GSDMD, the pass rate of EtBr, and the release of LDH and IL-1beta (P<0.05).	Bilirubin	46-55	interleukin 1 alpha	Rattus norvegicus	231-239
32361755-7	2020	A statistically significant (P < 10-5) association between predicted UGT1A1 activity and maximum change in total bilirubin was also observed (2.45-fold asymptomatic increase for low versus normal) without a corresponding change in ALT.	Bilirubin	113-122	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	69-75
32609436-13	2020	Large tumor (> 5 cm) and elevated total bilirubin were associated with high TESC expression (both P < 0.050).	Bilirubin	40-49	tescalcin	Homo sapiens	76-80
32433423-0	2020	Albumin-bilirubin score is associated with in-hospital mortality in critically ill patients with acute pancreatitis.	Bilirubin	8-17	albumin	Homo sapiens	0-7
32540477-3	2020	PNP40c-1 effectively prevented the accumulation of serum liver injury biomarkers including alanine aminotransferase, aspartate aminotransferase, alkaline phpsphatase and total bilirubin stimulated by CCl4.	Bilirubin	176-185	chemokine (C-C motif) ligand 4	Mus musculus	200-204
32353390-0	2020	Dosimetric Analysis and Normal-Tissue Complication Probability Modeling of Child-Pugh Score and Albumin-Bilirubin Grade Increase After Hepatic Irradiation.	Bilirubin	104-113	albumin	Homo sapiens	96-103
32353390-1	2020	PURPOSE: This study aimed to develop robust normal-tissue complication probability (NTCP) models for patients with hepatocellular carcinoma treated with radiation therapy (RT) using Child-Pugh (CP) score and albumin-bilirubin (ALBI) grade increase as endpoints for hepatic toxicity.	Bilirubin	216-225	albumin	Homo sapiens	208-215
32793733-6	2020	Most of the studies reported that hepatitis resulting from PD-1 inhibitor was manifested as elevated liver enzymes and bilirubin.	Bilirubin	119-128	programmed cell death 1	Homo sapiens	59-63
32815444-7	2020	Additionally, GDF-15 levels were correlated with urea levels (R2 = 0.742), and cystatin C levels were correlated with urea and bilirubin levels (R2 = 0.732).	Bilirubin	127-136	cystatin C	Homo sapiens	79-89
32407928-5	2020	OATP1B1 and OATP1B3 also play important roles in the hepatic uptake of many endogenous molecules, such as bile acids, bilirubin, and coproporphyrins.	Bilirubin	118-127	solute carrier organic anion transporter family member 1B1	Homo sapiens	0-7
32407928-5	2020	OATP1B1 and OATP1B3 also play important roles in the hepatic uptake of many endogenous molecules, such as bile acids, bilirubin, and coproporphyrins.	Bilirubin	118-127	solute carrier organic anion transporter family member 1B3	Homo sapiens	12-19
32407928-7	2020	Complete deficiency of OATP1B1 and 1B3 function in Rotor syndrome disrupts the hepatic reuptake of conjugated bilirubin with a corresponding clinical presentation as mild hyperbilirubinemia.	Bilirubin	110-119	solute carrier organic anion transporter family member 1B1	Homo sapiens	23-38
32760278-7	2020	HO-1 is an enzyme that degrades heme groups, leading to the production of potent antioxidant, anti-inflammatory, and bactericidal mediators, such as biliverdin, bilirubin, and CO.	Bilirubin	161-170	heme oxygenase 1	Homo sapiens	0-4
31693091-9	2020	Administration of APT102 in vivo enhanced the beneficial effects of endogenous Cd39 boosted by the administration of the aryl-hydrocarbon-receptor (AhR) ligand unconjugated bilirubin (UCB).	Bilirubin	173-182	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	79-83
31693091-9	2020	Administration of APT102 in vivo enhanced the beneficial effects of endogenous Cd39 boosted by the administration of the aryl-hydrocarbon-receptor (AhR) ligand unconjugated bilirubin (UCB).	Bilirubin	173-182	aryl hydrocarbon receptor	Homo sapiens	121-146
31693091-9	2020	Administration of APT102 in vivo enhanced the beneficial effects of endogenous Cd39 boosted by the administration of the aryl-hydrocarbon-receptor (AhR) ligand unconjugated bilirubin (UCB).	Bilirubin	173-182	aryl hydrocarbon receptor	Homo sapiens	148-151
32802055-0	2020	Relationship between Serum Indirect Bilirubin Level and Insulin Sensitivity: Results from Two Independent Cohorts of Obese Patients with Impaired Glucose Regulation and Type 2 Diabetes Mellitus in China.	Bilirubin	36-45	insulin	Homo sapiens	56-63
32802055-10	2020	Conclusions: The relationships between different types of bilirubin and insulin sensitivity varied.	Bilirubin	58-67	insulin	Homo sapiens	72-79
32802055-11	2020	Serum indirect bilirubin might be a protective factor that enhances insulin sensitivity.	Bilirubin	15-24	insulin	Homo sapiens	68-75
32404366-0	2020	Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator-activated receptor alpha.	Bilirubin	0-9	peroxisome proliferator activated receptor alpha	Mus musculus	114-162
32404366-4	2020	Bilirubin exerted its effects by recruiting and dissociating specific coregulators in WAT, driving the expression of PPARalpha target genes such as uncoupling protein 1 (Ucp1) and adrenoceptor beta 3 (Adrb3).	Bilirubin	0-9	peroxisome proliferator activated receptor alpha	Mus musculus	117-126
32404366-4	2020	Bilirubin exerted its effects by recruiting and dissociating specific coregulators in WAT, driving the expression of PPARalpha target genes such as uncoupling protein 1 (Ucp1) and adrenoceptor beta 3 (Adrb3).	Bilirubin	0-9	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	148-168
32404366-4	2020	Bilirubin exerted its effects by recruiting and dissociating specific coregulators in WAT, driving the expression of PPARalpha target genes such as uncoupling protein 1 (Ucp1) and adrenoceptor beta 3 (Adrb3).	Bilirubin	0-9	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	170-174
32404366-4	2020	Bilirubin exerted its effects by recruiting and dissociating specific coregulators in WAT, driving the expression of PPARalpha target genes such as uncoupling protein 1 (Ucp1) and adrenoceptor beta 3 (Adrb3).	Bilirubin	0-9	adrenergic receptor, beta 3	Mus musculus	201-206
32404366-5	2020	We also found that bilirubin is a selective ligand for PPARalpha and does not affect the activities of the related proteins PPARgamma or PPARdelta.	Bilirubin	19-28	peroxisome proliferator activated receptor alpha	Mus musculus	55-64
32404366-7	2020	We conclude that bilirubin strongly affects organismal body weight by reshaping the PPARalpha coregulator profile, remodeling WAT to improve metabolic function, and reducing fat accumulation.	Bilirubin	17-26	peroxisome proliferator activated receptor alpha	Mus musculus	84-93
33612462-2	2020	Where it was found to revert the alteration induced by CCl4 in liver structure and function by improving the body weights, liver index, liver and bile duct specific enzymes, liver conjugative and synthetic markers, reduced glutathione and the total bilirubin/ albumin ratio while increasing the percent inhibition of lipid peroxidation in test groups treated with extract in doses of 400 and 800 mg/kg body weight as compared to negative control group only treated with CCl4 3mL/kg that showed entirely opposite picture of all these parameters.	Bilirubin	249-258	C-C motif chemokine ligand 4	Rattus norvegicus	55-59
32325405-0	2020	Physiological concentrations of bilirubin control inflammatory response by inhibiting NF-kappaB and inflammasome activation.	Bilirubin	32-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	86-95
32325405-6	2020	In vitro, bilirubin inhibited caspase-1 maturation and IL-1beta secretion in NLRP3, AIM2, and NLRC4 inflammasomes.	Bilirubin	10-19	caspase 1	Mus musculus	30-39
32325405-6	2020	In vitro, bilirubin inhibited caspase-1 maturation and IL-1beta secretion in NLRP3, AIM2, and NLRC4 inflammasomes.	Bilirubin	10-19	interleukin 1 alpha	Mus musculus	55-63
32325405-6	2020	In vitro, bilirubin inhibited caspase-1 maturation and IL-1beta secretion in NLRP3, AIM2, and NLRC4 inflammasomes.	Bilirubin	10-19	NLR family, pyrin domain containing 3	Mus musculus	77-82
32325405-6	2020	In vitro, bilirubin inhibited caspase-1 maturation and IL-1beta secretion in NLRP3, AIM2, and NLRC4 inflammasomes.	Bilirubin	10-19	absent in melanoma 2	Mus musculus	84-88
32325405-6	2020	In vitro, bilirubin inhibited caspase-1 maturation and IL-1beta secretion in NLRP3, AIM2, and NLRC4 inflammasomes.	Bilirubin	10-19	NLR family, CARD domain containing 4	Mus musculus	94-99
32325405-7	2020	Besides, bilirubin inhibited the secretion of TNF-alpha and IL-6 in LPS-primed macrophages by reduced phosphorylation of IkappaB-alpha and p65, indicating the inhibition of the NF-kappaB pathway.	Bilirubin	9-18	tumor necrosis factor	Mus musculus	46-55
32325405-7	2020	Besides, bilirubin inhibited the secretion of TNF-alpha and IL-6 in LPS-primed macrophages by reduced phosphorylation of IkappaB-alpha and p65, indicating the inhibition of the NF-kappaB pathway.	Bilirubin	9-18	interleukin 6	Mus musculus	60-64
32325405-7	2020	Besides, bilirubin inhibited the secretion of TNF-alpha and IL-6 in LPS-primed macrophages by reduced phosphorylation of IkappaB-alpha and p65, indicating the inhibition of the NF-kappaB pathway.	Bilirubin	9-18	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	121-134
32325405-7	2020	Besides, bilirubin inhibited the secretion of TNF-alpha and IL-6 in LPS-primed macrophages by reduced phosphorylation of IkappaB-alpha and p65, indicating the inhibition of the NF-kappaB pathway.	Bilirubin	9-18	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	139-142
32325405-7	2020	Besides, bilirubin inhibited the secretion of TNF-alpha and IL-6 in LPS-primed macrophages by reduced phosphorylation of IkappaB-alpha and p65, indicating the inhibition of the NF-kappaB pathway.	Bilirubin	9-18	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	177-186
32325405-8	2020	In vivo, bilirubin significantly inhibited the release of IL-1beta and TNF-alpha, resulting in an increased survival rate of mice with LPS-induced sepsis.	Bilirubin	9-18	interleukin 1 alpha	Mus musculus	58-66
32325405-8	2020	In vivo, bilirubin significantly inhibited the release of IL-1beta and TNF-alpha, resulting in an increased survival rate of mice with LPS-induced sepsis.	Bilirubin	9-18	tumor necrosis factor	Mus musculus	71-80
32325405-9	2020	Our study demonstrates a protective role of physiological concentrations of bilirubin against inflammation, the mechanisms of which involve the inhibition of the NF-kappaB signaling pathway as well as control of the activation of inflammasomes.	Bilirubin	76-85	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	162-171
32552645-12	2021	MBL had a significant negative correlation with ascitic total leukocytic count (TLC), also with serum creatinine, bilirubin, PT, INR and MELD score among SBP patients.	Bilirubin	114-123	mannose binding lectin 2	Homo sapiens	0-3
32378294-9	2020	Additionally, we found that patients carrying wild-type alleles of all three UGT1A genes had lower serum bilirubin (25 vs. 38 micromol/L, P = .02) and serum cholesterol (195 vs. 223 mg/dL), P = .035) at first presentation.	Bilirubin	105-114	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	77-82
32612533-9	2020	Bilirubin could significantly attenuate ferroptosis in isolated islets, along with reduced oxidative stress, elevated GPX4 expression and upregulation of Nrf2/HO-1.	Bilirubin	0-9	glutathione peroxidase 4	Mus musculus	118-122
32612533-9	2020	Bilirubin could significantly attenuate ferroptosis in isolated islets, along with reduced oxidative stress, elevated GPX4 expression and upregulation of Nrf2/HO-1.	Bilirubin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	154-158
32612533-9	2020	Bilirubin could significantly attenuate ferroptosis in isolated islets, along with reduced oxidative stress, elevated GPX4 expression and upregulation of Nrf2/HO-1.	Bilirubin	0-9	heme oxygenase 1	Mus musculus	159-163
32626734-7	2020	Circulating FGF19 levels strongly correlated with C4 (r = -0.695, p < 0.0001), direct bilirubin (r = 0.598, p = 0.0001), and total bile acids (r = 0.595, p = 0.002).	Bilirubin	86-95	fibroblast growth factor 19	Homo sapiens	12-17
32243974-10	2020	Collectively, for the first time, this study demonstrated that bilirubin nanomedicine, BRSNPs, are effective in alleviating experimental acute pancreatitis, and the mechanisms are associated with its inhibition of NF-kappaB regulated pro-inflammatory signaling and activation of Nrf2-regulated cytoprotective protein expression.	Bilirubin	63-72	NFE2 like bZIP transcription factor 2	Homo sapiens	279-283
32393019-6	2020	More importantly, they can efficiently adsorb bilirubin from bovine serum albumin (BSA) solution or even in 100% fetal bovine serum (FBS) due to their high selectivity.	Bilirubin	46-55	albumin	Homo sapiens	68-81
32612873-1	2020	The human UDP-glucuronosyltransferase 1A1 (UGT1A1), one of the most essential conjugative enzymes, is responsible for the metabolism and detoxification of bilirubin and other endogenous substances, as well as many different xenobiotic compounds.	Bilirubin	155-164	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	10-41
32188584-6	2020	Our data demonstrated that enforced Snail expression resulted in liver and hepatocyte enlargement, inflammatory cell infiltration in the liver, lipid accumulation in hepatocytes, substantial increases in serum alanine transaminase and bile acids, yellow discoloration of tissues caused by bilirubin accumulation, and liver tumorigenesis.	Bilirubin	289-298	snail family zinc finger 1	Mus musculus	36-41
31553814-6	2020	In newborns with CN1, unconjugated bilirubin increased 4.3 +- 1.1 mg/dL per day.	Bilirubin	35-44	5'-nucleotidase, cytosolic IA	Homo sapiens	17-20
32612873-1	2020	The human UDP-glucuronosyltransferase 1A1 (UGT1A1), one of the most essential conjugative enzymes, is responsible for the metabolism and detoxification of bilirubin and other endogenous substances, as well as many different xenobiotic compounds.	Bilirubin	155-164	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	43-49
31563131-4	2020	Anti-factor Xa is a chromogenic assay, which may be biased by the frequently elevated values of bilirubin and free hemoglobin in ECMO patients.	Bilirubin	96-105	coagulation factor X	Homo sapiens	5-14
32528832-7	2020	Since bilirubin and bile acids are the substrates of OATP1B2, the contents of total bilirubin, direct bilirubin, indirect bilirubin, and total bile acids in serum are significantly higher in Slco1b2 KO rats than the data of wild-type rats.	Bilirubin	6-15	solute carrier organic anion transporter family member 1B2	Rattus norvegicus	191-198
32375339-5	2020	Results: BChE activity negatively correlated with other liver parameters (bilirubin, gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and C-reactive protein (CRP)), and positively correlated with albumin levels, respectively (p < 0.01).	Bilirubin	74-83	butyrylcholinesterase	Homo sapiens	9-13
32375339-7	2020	In multivariate analysis, tumor stage, tumor grade, administration of chemotherapy, bilirubin levels and a low BChE activity (hazard ratio: 1.42, 95% confidence interval: 1.10-1.82; p = 0.006) were identified as independent prognostic factors.	Bilirubin	84-93	butyrylcholinesterase	Homo sapiens	111-115
31948914-10	2020	Bilirubin levels decreased immediately after ET (P < 0.001).	Bilirubin	0-9	major facilitator superfamily domain containing 11	Homo sapiens	45-47
32461506-0	2021	Prediction of Sufficient Liver Enhancement on the Gadoxetate Disodium-enhanced Hepatobiliary Phase Imaging Using Transitional Phase Images and Albumin-bilirubin Grade.	Bilirubin	151-160	albumin	Homo sapiens	143-150
32455921-3	2020	Liver growth factor (LGF) is an albumin-bilirubin complex that stimulates axonal growth in the striatum and protects DA neurons in the SN of 6-hydroxydopamine-lesioned rats.	Bilirubin	40-49	myotrophin	Rattus norvegicus	6-19
32715285-7	2020	Thrombomodulin-mediated inhibition significantly decreased with increasing PT/INR, aPTT, and total bilirubin levels and with decreasing factor V activity and albumin levels.	Bilirubin	99-108	thrombomodulin	Homo sapiens	0-14
31087315-6	2020	RESULTS: There was statistically significant difference of the serum bilirubin level between the Gly71Arg homozygous and no mutation group in the ABO HDN patients (p < 0.05).	Bilirubin	69-78	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	146-149
31087315-7	2020	When hyperbilirubinemia was defined as serum bilirubin concentration >342 mumol/L, the incidence of hyperbilirubinemia between patients of UGT1A1 and non-UGT1A1 mutations in the ABO HDN group was significantly different (p < 0.05).	Bilirubin	10-19	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	178-181
32528832-7	2020	Since bilirubin and bile acids are the substrates of OATP1B2, the contents of total bilirubin, direct bilirubin, indirect bilirubin, and total bile acids in serum are significantly higher in Slco1b2 KO rats than the data of wild-type rats.	Bilirubin	84-93	solute carrier organic anion transporter family member 1B2	Rattus norvegicus	191-198
32528832-7	2020	Since bilirubin and bile acids are the substrates of OATP1B2, the contents of total bilirubin, direct bilirubin, indirect bilirubin, and total bile acids in serum are significantly higher in Slco1b2 KO rats than the data of wild-type rats.	Bilirubin	84-93	solute carrier organic anion transporter family member 1B2	Rattus norvegicus	191-198
32528832-7	2020	Since bilirubin and bile acids are the substrates of OATP1B2, the contents of total bilirubin, direct bilirubin, indirect bilirubin, and total bile acids in serum are significantly higher in Slco1b2 KO rats than the data of wild-type rats.	Bilirubin	84-93	solute carrier organic anion transporter family member 1B2	Rattus norvegicus	191-198
32006543-1	2020	OBJECTIVE: Heme oxygenase-1 (HO-1) degrades heme to CO, iron, and biliverdin/bilirubin.	Bilirubin	77-86	heme oxygenase 1	Homo sapiens	11-27
32006543-1	2020	OBJECTIVE: Heme oxygenase-1 (HO-1) degrades heme to CO, iron, and biliverdin/bilirubin.	Bilirubin	77-86	heme oxygenase 1	Homo sapiens	29-33
32006543-2	2020	Although serum bilirubin levels were often reported in patients with coronary artery disease (CAD), HO-1 levels in patients with CAD and the association between HO-1 and bilirubin levels have not been clarified.	Bilirubin	170-179	heme oxygenase 1	Homo sapiens	161-165
32032568-9	2020	Samples with high endogenous ERFE levels were suppressed by haemoglobin (>=2 g/L), bilirubin (>=200 micromol/L), lipaemia (>1 g/L), and freeze thawing (>=2 cycles), but this was not observed with low ERFE concentrations.	Bilirubin	83-92	erythroferrone	Homo sapiens	29-33
32072161-9	2020	At the start of FO, miR-122 correlated with conjugated bilirubin (r = 0.56; P = 0.038).	Bilirubin	55-64	microRNA 122	Homo sapiens	20-27
32072161-12	2020	CONCLUSIONS: In this small cohort of young children with IFALD, miR-122 decreased with FO therapy and correlated with conjugated bilirubin.	Bilirubin	129-138	microRNA 122	Homo sapiens	64-71
31523825-4	2020	Glomerular Filtration Rate (GFR) was estimated using GfR Assessment In Liver disease (GRAIL) developed amongst patients with cirrhosis (Asrani SK Hepatology.2018; www.bswh.md/grail).Multivariate Cox proportional hazards analysis models were utilized to compare predicted 90-day WL mortality between MELD-GRAIL-Na (re-estimated bilirubin, INR, sodium and GRAIL) vs. MELD-Na.	Bilirubin	327-336	ring finger protein 128	Homo sapiens	86-91
32072161-10	2020	At ~3 mo of FO, miR-122 correlated with conjugated bilirubin (r = 0.56; P = 0.045).	Bilirubin	51-60	microRNA 122	Homo sapiens	16-23
32655922-0	2020	Competitive Binding of Bilirubin and Fatty Acid on Serum Albumin Affects Wear of UHMWPE.	Bilirubin	23-32	albumin	Homo sapiens	57-64
32655922-10	2020	We believe the conformational change in albumin by binding bilirubin makes it more likely to form molecular bridges between UHMWPE and the metal counterface, thus increasing adhesive wear.	Bilirubin	59-68	albumin	Homo sapiens	40-47
32655922-13	2020	Ultimately, UHMWPE wear rate is driven by the competitive binding of bilirubin and fatty acid to albumin.	Bilirubin	69-78	albumin	Homo sapiens	97-104
32278282-8	2020	Finally, silencing HO-1 expression partially rescued the proliferative and migratory response of canagliflozin-treated SMCs, and this was reversed by carbon monoxide and bilirubin.	Bilirubin	170-179	heme oxygenase 1	Homo sapiens	19-23
31086285-1	2020	BACKGROUND: To assess the postnatal rate of rise (ROR) of total serum bilirubin (TSB) in very low birth weight (VLBW) preterm infants, to determine risk factors associated with a rapid rise (&gt;90th percentile), and to compare ROR and hour-specific TSB at postnatal 12-48 h with data of term infants retrieved from the literature.	Bilirubin	70-79	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	50-53
32365693-8	2020	EAF significantly inhibited CCl4-induced elevation of alanine aminotransferase (ALT), aspartate transaminase (AST), total bilirubin (TB), total cholesterol (TC), and triglycerides (TG), in the blood serum and prevented lipid peroxidation and restored superoxide dismutase (SOD) activity and glutathione (GSH) content in liver tissues.	Bilirubin	122-131	C-C motif chemokine ligand 4	Rattus norvegicus	28-32
32366000-0	2020	Survival of Patients with Hepatocellular Carcinoma in Renal Insufficiency: Prognostic Role of Albumin-Bilirubin Grade.	Bilirubin	102-111	albumin	Homo sapiens	94-101
32365693-8	2020	EAF significantly inhibited CCl4-induced elevation of alanine aminotransferase (ALT), aspartate transaminase (AST), total bilirubin (TB), total cholesterol (TC), and triglycerides (TG), in the blood serum and prevented lipid peroxidation and restored superoxide dismutase (SOD) activity and glutathione (GSH) content in liver tissues.	Bilirubin	133-135	C-C motif chemokine ligand 4	Rattus norvegicus	28-32
32425592-1	2020	Purpose: Biliverdin reductase A (BLVRA) is a pleiotropic enzyme that converts biliverdin-IX-alpha into the antioxidant and anti-nitrosative compound, bilirubin-IX-alpha.	Bilirubin	150-168	biliverdin reductase A	Homo sapiens	9-31
32425592-1	2020	Purpose: Biliverdin reductase A (BLVRA) is a pleiotropic enzyme that converts biliverdin-IX-alpha into the antioxidant and anti-nitrosative compound, bilirubin-IX-alpha.	Bilirubin	150-168	biliverdin reductase A	Homo sapiens	33-38
32300559-5	2020	Results: On multivariate analysis of the training cohort, serum CA 19-9, albumin-bilirubin grade at recurrence, time from primary resection to recurrence, tumor number at recurrence, and treatment for recurrence were selected for the model.	Bilirubin	81-90	albumin	Homo sapiens	73-80
32271881-7	2020	The presence of high levels of bilirubin and its derivatives, implicated in Alzheimer"s disease, by binding to L-PGDS may reduce its chaperone activity.	Bilirubin	31-40	prostaglandin D2 synthase	Homo sapiens	111-117
32344934-8	2020	Significant reductions in plasma lipids and lipoproteins but increased circulating bilirubin concentrations were observed in patients who switched to RPV/FTC/TDF.	Bilirubin	83-92	sex determining region Y	Homo sapiens	158-161
32293336-4	2020	RESULTS: IDH1/2 mutation was related to decreased preoperative serum total bilirubin (P = 0.039), ferritin (P = 0.000) and higher histological differentiation (P = 0.024), and was associated with prolonged disease-free survival (P = 0.009) and a trend toward increased overall survival (P = 0.126) in small duct type of ICCs.	Bilirubin	75-84	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	9-15
33659548-1	2020	Heme oxygenase-1 (HO-1) is a stress responsive enzyme that metabolizes heme and releases free iron, carbon monoxide (CO), and biliverdin (BV), which rapidly undergoes conversion to bilirubin (BL).	Bilirubin	181-190	heme oxygenase 1	Rattus norvegicus	0-16
33659548-1	2020	Heme oxygenase-1 (HO-1) is a stress responsive enzyme that metabolizes heme and releases free iron, carbon monoxide (CO), and biliverdin (BV), which rapidly undergoes conversion to bilirubin (BL).	Bilirubin	181-190	heme oxygenase 1	Rattus norvegicus	18-22
33659548-2	2020	Estimation of bilirubin is the basis of HO-1 assay.	Bilirubin	14-23	heme oxygenase 1	Rattus norvegicus	40-44
33659548-6	2020	The main steps include: (1) Preparation of macrophage microsomal fraction containing HO-1 (2) Isolation of rat liver cytosolic fraction containing biliverdin reductase and (3) Assessment of heme oxygenase-1 activity by spectrophotometric detection of bilirubin.	Bilirubin	251-260	heme oxygenase 1	Rattus norvegicus	190-206
32035059-2	2020	In this study, we hypothesized that heme oxygenase-1 (HO-1), an enzyme responsible for degradation of heme to carbon monoxide (CO), bilirubin, and iron is an important regulator of inflammation and epithelial responses in the prostate.	Bilirubin	132-141	heme oxygenase 1	Mus musculus	36-52
32411760-0	2020	Comparison between Child-Pugh Score and albumin-bilirubin grade in patients treated with the combination therapy of transarterial chemoembolization and sorafenib for hepatocellular carcinoma.	Bilirubin	48-57	albumin	Homo sapiens	40-47
32411776-0	2020	Prognostic value of the albumin-bilirubin grade in patients with hepatocellular carcinoma and other liver diseases.	Bilirubin	32-41	albumin	Homo sapiens	24-31
32411776-3	2020	More recently, an alternative to traditional CP grade has emerged in the form of albumin-bilirubin (ALBI) grade.	Bilirubin	89-98	albumin	Homo sapiens	81-88
32035059-2	2020	In this study, we hypothesized that heme oxygenase-1 (HO-1), an enzyme responsible for degradation of heme to carbon monoxide (CO), bilirubin, and iron is an important regulator of inflammation and epithelial responses in the prostate.	Bilirubin	132-141	heme oxygenase 1	Mus musculus	54-58
31980500-3	2020	The expression of UGT1A1 is developmentally delayed in liver and intestines resulting in the accumulation of serum bilirubin during the neonatal period.	Bilirubin	115-124	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	18-24
31135706-9	2020	Together, current biochemical and pharmacological evidence suggests key roles for alpha7-nAChRs and the bilirubin byproduct of the HO-1 signaling in the nicotine counteraction of renal dysfunction and reduced adenosinergic renal vasodilator capacity in endotoxic rats.	Bilirubin	104-113	heme oxygenase 1	Rattus norvegicus	131-135
31980500-4	2020	Induction of UGT1A1 in newborn hUGT1 mice leads to rapid reduction in total serum bilirubin (TSB) levels, a phenotype measurement that allows for an accurate prediction on UGT1A1 expression.	Bilirubin	82-91	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	13-19
31980500-4	2020	Induction of UGT1A1 in newborn hUGT1 mice leads to rapid reduction in total serum bilirubin (TSB) levels, a phenotype measurement that allows for an accurate prediction on UGT1A1 expression.	Bilirubin	82-91	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	31-36
31980500-10	2020	An LXR specific enhancer site on the UGT1A1 gene was identified, along with convincing evidence that LXRalpha is crucial in maintaining constitutive expression of UGT1A1 in adult hUGT1 mice SIGNIFICANCE STATEMENT: Implementing a reverse genetics approach, it has been established that activation of LXRalpha, and not LXRbeta, is responsible for induction of liver UGT1A1 and metabolism of serum bilirubin in neonatal hUGT1 mice.	Bilirubin	395-404	nuclear receptor subfamily 1, group H, member 2	Mus musculus	3-6
31980500-10	2020	An LXR specific enhancer site on the UGT1A1 gene was identified, along with convincing evidence that LXRalpha is crucial in maintaining constitutive expression of UGT1A1 in adult hUGT1 mice SIGNIFICANCE STATEMENT: Implementing a reverse genetics approach, it has been established that activation of LXRalpha, and not LXRbeta, is responsible for induction of liver UGT1A1 and metabolism of serum bilirubin in neonatal hUGT1 mice.	Bilirubin	395-404	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	37-43
31980500-10	2020	An LXR specific enhancer site on the UGT1A1 gene was identified, along with convincing evidence that LXRalpha is crucial in maintaining constitutive expression of UGT1A1 in adult hUGT1 mice SIGNIFICANCE STATEMENT: Implementing a reverse genetics approach, it has been established that activation of LXRalpha, and not LXRbeta, is responsible for induction of liver UGT1A1 and metabolism of serum bilirubin in neonatal hUGT1 mice.	Bilirubin	395-404	nuclear receptor subfamily 1, group H, member 3	Mus musculus	101-109
31980500-10	2020	An LXR specific enhancer site on the UGT1A1 gene was identified, along with convincing evidence that LXRalpha is crucial in maintaining constitutive expression of UGT1A1 in adult hUGT1 mice SIGNIFICANCE STATEMENT: Implementing a reverse genetics approach, it has been established that activation of LXRalpha, and not LXRbeta, is responsible for induction of liver UGT1A1 and metabolism of serum bilirubin in neonatal hUGT1 mice.	Bilirubin	395-404	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	163-169
31980500-10	2020	An LXR specific enhancer site on the UGT1A1 gene was identified, along with convincing evidence that LXRalpha is crucial in maintaining constitutive expression of UGT1A1 in adult hUGT1 mice SIGNIFICANCE STATEMENT: Implementing a reverse genetics approach, it has been established that activation of LXRalpha, and not LXRbeta, is responsible for induction of liver UGT1A1 and metabolism of serum bilirubin in neonatal hUGT1 mice.	Bilirubin	395-404	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	179-184
31980500-10	2020	An LXR specific enhancer site on the UGT1A1 gene was identified, along with convincing evidence that LXRalpha is crucial in maintaining constitutive expression of UGT1A1 in adult hUGT1 mice SIGNIFICANCE STATEMENT: Implementing a reverse genetics approach, it has been established that activation of LXRalpha, and not LXRbeta, is responsible for induction of liver UGT1A1 and metabolism of serum bilirubin in neonatal hUGT1 mice.	Bilirubin	395-404	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	163-169
31858458-8	2020	The nanoconjugate induced reactive oxygen species (ROS) formation, DNA strand breaks, and apoptotic morphological changes in the P-gp-overexpressing drug-resistant cells to a greater degree than bilirubin treatment alone.	Bilirubin	195-204	ATP binding cassette subfamily B member 1	Homo sapiens	129-133
31495946-5	2020	In patients with complete UGT1A1 deficiency (type 1 CNS [CNS-I]), unconjugated bilirubin levels increase 3-6 mg/dL per day during the newborn period and reach neurologically dangerous levels between 5 and 14 days of age.	Bilirubin	79-88	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	26-32
32366561-11	2020	TB was positively correlated with Hb and Alb, but negatively correlated with ESR and CRP (p<0.05).	Bilirubin	0-2	albumin	Homo sapiens	41-44
31943574-11	2020	Remarkably, this combination demonstrated a power similar to CA19-9 to discriminate cancer from BD (AUC = 0.764), and THBS2 provided an additive value in patients with high expression levels of bilirubin.	Bilirubin	194-203	thrombospondin 2	Homo sapiens	118-123
32366561-11	2020	TB was positively correlated with Hb and Alb, but negatively correlated with ESR and CRP (p<0.05).	Bilirubin	0-2	C-reactive protein	Homo sapiens	85-88
31602632-10	2020	Homozygosity (41%) for the promoter variant of UGT1A1 (Gilbert syndrome) led to a significantly higher mean bilirubin level (126 54 micromol/l) with a higher frequency of cholelithiasis (30%) (P &lt; 0 001).	Bilirubin	108-117	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	47-53
32724271-6	2020	We found a significant negative association between total bilirubin and CRP, TNF-alpha, visfatin and resistin values, and a significant positive association between total bilirubin and adiponectin values in both normal-weight and overweight groups.	Bilirubin	58-67	C-reactive protein	Homo sapiens	72-75
31888882-8	2020	After stratification by UGT1A1 phenotypes, there was a significant decrease in total bilirubin among all phenotypes, conjugated bilirubin among intermediate metabolizers, and unconjugated bilirubin among normal and intermediate metabolizers.	Bilirubin	85-94	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	24-30
32724271-6	2020	We found a significant negative association between total bilirubin and CRP, TNF-alpha, visfatin and resistin values, and a significant positive association between total bilirubin and adiponectin values in both normal-weight and overweight groups.	Bilirubin	171-180	adiponectin, C1Q and collagen domain containing	Homo sapiens	185-196
32724271-7	2020	Importantly, after adjusting for body mass index, we also found a significant negative association between total serum bilirubin levels and both visfatin and CRP serum levels.	Bilirubin	119-128	nicotinamide phosphoribosyltransferase	Homo sapiens	145-153
32724271-7	2020	Importantly, after adjusting for body mass index, we also found a significant negative association between total serum bilirubin levels and both visfatin and CRP serum levels.	Bilirubin	119-128	C-reactive protein	Homo sapiens	158-161
32724271-8	2020	Moreover, visfatin, resistin and CRP were predictors of the total serum bilirubin levels.	Bilirubin	72-81	nicotinamide phosphoribosyltransferase	Homo sapiens	10-18
32724271-8	2020	Moreover, visfatin, resistin and CRP were predictors of the total serum bilirubin levels.	Bilirubin	72-81	C-reactive protein	Homo sapiens	33-36
31972148-9	2020	RESULTS: In a multiple regression model adjusted for age, sex, insulin resistance, body mass index and alcohol use, circulating PCSK9 level was positively associated with albumin (beta=0.102, P=0.008), alkaline phosphatase (beta=0.201, P&lt;0.0001), ALT (beta=0.238, P&lt;0.0001), AST (beta=0.120, P=0.003) and GGT (beta=0.103, P=0.007) and negatively associated with total bilirubin (beta= -0.150, P&lt;0.0001).	Bilirubin	374-383	proprotein convertase subtilisin/kexin type 9	Homo sapiens	128-133
31888882-8	2020	After stratification by UGT1A1 phenotypes, there was a significant decrease in total bilirubin among all phenotypes, conjugated bilirubin among intermediate metabolizers, and unconjugated bilirubin among normal and intermediate metabolizers.	Bilirubin	128-137	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	24-30
31888882-8	2020	After stratification by UGT1A1 phenotypes, there was a significant decrease in total bilirubin among all phenotypes, conjugated bilirubin among intermediate metabolizers, and unconjugated bilirubin among normal and intermediate metabolizers.	Bilirubin	128-137	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	24-30
31888882-9	2020	The data also show that UGT1A1 genotype predicts serum bilirubin levels at baseline, but this relationship is lost after efavirenz treatment.	Bilirubin	55-64	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	24-30
31888882-11	2020	Our data suggest that efavirenz may alter bilirubin disposition mainly through induction of UGT1A1 metabolism and efflux through multidrug resistance-associated protein 2.	Bilirubin	42-51	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	92-98
31888882-11	2020	Our data suggest that efavirenz may alter bilirubin disposition mainly through induction of UGT1A1 metabolism and efflux through multidrug resistance-associated protein 2.	Bilirubin	42-51	ATP binding cassette subfamily C member 2	Homo sapiens	129-170
31764415-4	2020	There was a positive correlation between serum IL-33 and AST, ALT, bilirubin (total and direct) levels and fibrosis stage among the BA group.	Bilirubin	67-76	interleukin 33	Homo sapiens	47-52
31749099-11	2020	Moreover, levels of miR-US25-1-5p in serum EVs showed positive correlations with serum levels of gamma-glutamyl transpeptidase, direct bilirubin, and total bile acid.	Bilirubin	135-144	membrane associated ring-CH-type finger 8	Homo sapiens	20-23
31749099-12	2020	Levels of miR-UL112-3p in serum EVs showed a positive correlation with serum levels of direct bilirubin.	Bilirubin	94-103	membrane associated ring-CH-type finger 8	Homo sapiens	10-13
32100665-9	2020	High BCS groups had greater milk fat content and elevated plasma nonesterified fatty acids (NEFA), beta hydroxybutyrate (BHB) and bilirubin concentrations.	Bilirubin	130-139	BCS	Bos taurus	5-8
31566904-10	2020	After adjusting for significant covariates (INR, bilirubin, acetaminophen aetiology), the development of SLI was independently associated with decreased 21-day TFS (OR 0.71, P = .03) in ALF patients (C-index 0.78).	Bilirubin	49-58	SHC adaptor protein 2	Homo sapiens	105-108
32204767-2	2020	Uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1), organic anion transporter polypeptide 2 (OATP2), heme oxygenase 1 (HO-1), and biliverdin reductase A (BLVRA) play crucial roles in the metabolism of bilirubin.	Bilirubin	207-216	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-47
32051225-0	2020	Bilirubin enhances the activity of ASIC channels to exacerbate neurotoxicity in neonatal hyperbilirubinemia in mice.	Bilirubin	0-9	acid-sensing (proton-gated) ion channel 1	Mus musculus	35-39
32116422-0	2020	Modified Child-Pugh grade vs albumin-bilirubin grade for predicting prognosis of hepatocellular carcinoma patients after hepatectomy.	Bilirubin	37-46	albumin	Homo sapiens	29-36
32116422-4	2020	AIM: To compare the predictive power of the modified Child-Pugh (MCP) and albumin-bilirubin (ALBI) grades for the long-term outcome of HCC.	Bilirubin	82-91	albumin	Homo sapiens	74-81
31659612-0	2020	A New Prognostic Model Based on Albumin-Bilirubin Grade for Hepatocellular Carcinoma Beyond the Milan Criteria.	Bilirubin	40-49	albumin	Homo sapiens	32-39
31927945-6	2020	PLCD was synthesized by conjugating activated beta-cyclodextrin (beta-CD) to the sidechain of epsilon-polylysine (PLL) and acted as a carrier to load bilirubin via host-guest interactions.	Bilirubin	150-159	beta-carotene oxygenase 1	Mus musculus	65-72
32095231-8	2020	Total bilirubin and creatinine clearance were the most predictive covariates for apparent riociguat metabolic clearance to M1 (CLf,M1/F) and for apparent riociguat clearance through remaining pathways (CLe,r/F), respectively.	Bilirubin	6-15	myoregulin	Homo sapiens	123-125
31659612-2	2020	We proposed and validated an albumin-bilirubin (ALBI)-based model for HCC beyond Milan criteria, the ALBI-HOME, for these patients.	Bilirubin	37-46	albumin	Homo sapiens	29-36
32010304-4	2020	BS significantly ameliorated CCl4-induced increases in serum aspartate (AST) and alanine transaminase (ALT) levels, reduced lactate dehydrogenase (LDH) activities in addition to restoring total bilirubin, triglyceride and albumin levels.	Bilirubin	194-203	C-C motif chemokine ligand 4	Rattus norvegicus	29-33
31738583-1	2020	The presence of oxyhaemoglobin and biliverdin interferes with the method recommended by the UK NEQAS Specialist Advisory group for EQA of CSF Proteins and Biochemistry for estimating of the net bilirubin absorbance in CSF.	Bilirubin	194-203	colony stimulating factor 2	Homo sapiens	218-221
31177870-8	2020	According to Spearman"s rank correlation, both GLP-1 and resisitin correlated positively with each other, insulin, homeostatic model assessment of insulin resistance, alanine aminotransferase (ALT), total bilirubin, and international normalized ratio while they correlated negatively with albumin (P &lt; .001).	Bilirubin	205-214	glucagon like peptide 1 receptor	Homo sapiens	47-52
32049823-9	2020	Serum TB correlated positively with UGT1A1 mutation load (gamma = 0.281, P = .048), hemoglobin (gamma = .359, P = .010) and hematocrit (gamma = 0.365, P = .010), but negatively with RBC lifespan (gamma = -0.336, P = .017).	Bilirubin	6-8	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	36-42
32082323-6	2020	Heme oxygenase-1 (HO-1, encoded by HMOX1) produces BV by heme degradation, while biliverdin reductase-A (BLVR-A) generates BR by the subsequent conversion of BV.	Bilirubin	123-125	heme oxygenase 1	Homo sapiens	0-22
32433020-11	2020	Distinct expression of UGT1A1, CYP2B6, CYP2C9, CYP3A4, and CYP7A1 genes explains the ability to clear toxins and bilirubin as observed in normal hepatocytes.	Bilirubin	113-122	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	23-29
32433020-11	2020	Distinct expression of UGT1A1, CYP2B6, CYP2C9, CYP3A4, and CYP7A1 genes explains the ability to clear toxins and bilirubin as observed in normal hepatocytes.	Bilirubin	113-122	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	31-37
32433020-11	2020	Distinct expression of UGT1A1, CYP2B6, CYP2C9, CYP3A4, and CYP7A1 genes explains the ability to clear toxins and bilirubin as observed in normal hepatocytes.	Bilirubin	113-122	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	39-45
32433020-11	2020	Distinct expression of UGT1A1, CYP2B6, CYP2C9, CYP3A4, and CYP7A1 genes explains the ability to clear toxins and bilirubin as observed in normal hepatocytes.	Bilirubin	113-122	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	47-53
32433020-11	2020	Distinct expression of UGT1A1, CYP2B6, CYP2C9, CYP3A4, and CYP7A1 genes explains the ability to clear toxins and bilirubin as observed in normal hepatocytes.	Bilirubin	113-122	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	59-65
32082323-6	2020	Heme oxygenase-1 (HO-1, encoded by HMOX1) produces BV by heme degradation, while biliverdin reductase-A (BLVR-A) generates BR by the subsequent conversion of BV.	Bilirubin	123-125	biliverdin reductase A	Homo sapiens	81-103
32082323-6	2020	Heme oxygenase-1 (HO-1, encoded by HMOX1) produces BV by heme degradation, while biliverdin reductase-A (BLVR-A) generates BR by the subsequent conversion of BV.	Bilirubin	123-125	biliverdin reductase A	Homo sapiens	105-109
32729434-5	2020	We also measured serum levels of unconjugated bilirubin (UCB) and found a significant negative correlation between UCB and FGF2 at serum levels in all the rats studied.	Bilirubin	46-55	fibroblast growth factor 2	Rattus norvegicus	123-127
32082188-3	2020	This review aims to provide an up-to-date and critical overview of the molecular mechanisms by which bilirubin derived from plasma or from HMOX1 activation in vascular cells affects endothelial function.	Bilirubin	101-110	heme oxygenase 1	Homo sapiens	139-144
32082188-5	2020	In this context, therapeutic interventions aimed at mildly increasing serum bilirubin as well as bilirubin generated endogenously by endothelial HMOX1 should be considered.	Bilirubin	97-106	heme oxygenase 1	Homo sapiens	145-150
31965023-7	2020	HLSC expressed UGT1A1 in vivo, induced a strong decrease in serum unconjugated bilirubin, thus significantly improving phenotype and survival compared to untreated controls.	Bilirubin	79-88	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	15-21
32009984-1	2019	Heme oxygenase (HO)-1 plays an important role during hibernation by catalyzing the degradation of heme to biliverdin/bilirubin, ferrous iron, and carbon monoxide, which activates the protective mechanisms against stress.	Bilirubin	117-126	heme oxygenase 1	Mesocricetus auratus	0-21
32295734-9	2020	RESULTS: The single predictors of the patients survival were the static values of AST with C-index 0.706 (0.5883-0.7494), ALT 0.6102 (0.4843-0.6857) and bilirubin 0.6224 (0.5537-0.6695).	Bilirubin	153-162	solute carrier family 17 member 5	Homo sapiens	82-85
31733348-4	2020	We found that bilirubin could markedly induce the expression of TNF-alpha and iNOS in glial cells, and even at low concentrations, the co-culture of glial cells with neurons significantly enhances neurotoxicity of bilirubin.	Bilirubin	14-23	tumor necrosis factor	Homo sapiens	64-73
31733348-4	2020	We found that bilirubin could markedly induce the expression of TNF-alpha and iNOS in glial cells, and even at low concentrations, the co-culture of glial cells with neurons significantly enhances neurotoxicity of bilirubin.	Bilirubin	14-23	nitric oxide synthase 2	Homo sapiens	78-82
31733348-4	2020	We found that bilirubin could markedly induce the expression of TNF-alpha and iNOS in glial cells, and even at low concentrations, the co-culture of glial cells with neurons significantly enhances neurotoxicity of bilirubin.	Bilirubin	214-223	tumor necrosis factor	Homo sapiens	64-73
31733348-4	2020	We found that bilirubin could markedly induce the expression of TNF-alpha and iNOS in glial cells, and even at low concentrations, the co-culture of glial cells with neurons significantly enhances neurotoxicity of bilirubin.	Bilirubin	214-223	nitric oxide synthase 2	Homo sapiens	78-82
31100458-8	2020	RESULTS: In the entire cohort, the median serum level of ALP increased from 1.54-fold the upper limit of normal at baseline to 1.64-fold the upper limit of normal at the last follow-up examination (P = .018); serum levels of transaminases and bilirubin also increased by a small amount between baseline and the last follow-up examination.	Bilirubin	243-252	alkaline phosphatase, placental	Homo sapiens	57-60
30556496-2	2020	Heme is first cleaved by the enzyme heme oxygenase (HO) to the linear tetrapyrrole biliverdin IXalpha (BV), and BV is then converted to bilirubin by biliverdin reductase (BVR).	Bilirubin	136-145	biliverdin reductase A	Homo sapiens	149-169
30556496-2	2020	Heme is first cleaved by the enzyme heme oxygenase (HO) to the linear tetrapyrrole biliverdin IXalpha (BV), and BV is then converted to bilirubin by biliverdin reductase (BVR).	Bilirubin	136-145	biliverdin reductase A	Homo sapiens	171-174
31639434-8	2020	Parallel effects were observed with bilirubin, which up-regulated apoptotic genes and CSF2 (colony-stimulating factor 2) and down-regulated antiapoptotic genes (BCL2 and BCL2L1), BMP3, BMP4 and RUNX2.	Bilirubin	36-45	colony stimulating factor 2	Homo sapiens	86-90
31639434-8	2020	Parallel effects were observed with bilirubin, which up-regulated apoptotic genes and CSF2 (colony-stimulating factor 2) and down-regulated antiapoptotic genes (BCL2 and BCL2L1), BMP3, BMP4 and RUNX2.	Bilirubin	36-45	colony stimulating factor 2	Homo sapiens	92-119
31639434-8	2020	Parallel effects were observed with bilirubin, which up-regulated apoptotic genes and CSF2 (colony-stimulating factor 2) and down-regulated antiapoptotic genes (BCL2 and BCL2L1), BMP3, BMP4 and RUNX2.	Bilirubin	36-45	BCL2 apoptosis regulator	Homo sapiens	161-165
31639434-8	2020	Parallel effects were observed with bilirubin, which up-regulated apoptotic genes and CSF2 (colony-stimulating factor 2) and down-regulated antiapoptotic genes (BCL2 and BCL2L1), BMP3, BMP4 and RUNX2.	Bilirubin	36-45	BCL2 like 1	Homo sapiens	170-176
31639434-8	2020	Parallel effects were observed with bilirubin, which up-regulated apoptotic genes and CSF2 (colony-stimulating factor 2) and down-regulated antiapoptotic genes (BCL2 and BCL2L1), BMP3, BMP4 and RUNX2.	Bilirubin	36-45	bone morphogenetic protein 3	Homo sapiens	179-183
31639434-8	2020	Parallel effects were observed with bilirubin, which up-regulated apoptotic genes and CSF2 (colony-stimulating factor 2) and down-regulated antiapoptotic genes (BCL2 and BCL2L1), BMP3, BMP4 and RUNX2.	Bilirubin	36-45	bone morphogenetic protein 4	Homo sapiens	185-189
31639434-8	2020	Parallel effects were observed with bilirubin, which up-regulated apoptotic genes and CSF2 (colony-stimulating factor 2) and down-regulated antiapoptotic genes (BCL2 and BCL2L1), BMP3, BMP4 and RUNX2.	Bilirubin	36-45	RUNX family transcription factor 2	Homo sapiens	194-199
32132870-8	2020	Relative expression of EFP, HERC5 and UBA1 in adjacent non-tumour tissues was positively associated with direct bilirubin levels (Spearman"s rho=0.31, 0.33 and 0.45; P=0.06, 0.05 and 0.01, respectively) and relative expression of USP18 in adjacent non-tumour tissues correlated negatively with ALT levels (Spearman"s rho= -0.33, P=0.03).	Bilirubin	112-121	tripartite motif containing 25	Homo sapiens	23-26
32132870-8	2020	Relative expression of EFP, HERC5 and UBA1 in adjacent non-tumour tissues was positively associated with direct bilirubin levels (Spearman"s rho=0.31, 0.33 and 0.45; P=0.06, 0.05 and 0.01, respectively) and relative expression of USP18 in adjacent non-tumour tissues correlated negatively with ALT levels (Spearman"s rho= -0.33, P=0.03).	Bilirubin	112-121	HECT and RLD domain containing E3 ubiquitin protein ligase 5	Homo sapiens	28-33
32132870-8	2020	Relative expression of EFP, HERC5 and UBA1 in adjacent non-tumour tissues was positively associated with direct bilirubin levels (Spearman"s rho=0.31, 0.33 and 0.45; P=0.06, 0.05 and 0.01, respectively) and relative expression of USP18 in adjacent non-tumour tissues correlated negatively with ALT levels (Spearman"s rho= -0.33, P=0.03).	Bilirubin	112-121	ubiquitin like modifier activating enzyme 1	Homo sapiens	38-42
31926081-5	2020	A significant positive correlation coefficient (r) of blood lead level with lipid peroxide (r = 0.44, p &lt; 0.001), uric acid (r = 0.33 p &lt; 0.05) and bilirubin (r = 0.35, p &lt; 0.05) and a negative correlation with SOD (r = -0.32, p &lt; 0.05), catalase (r = -0.33, p &lt; 0.05), ceruloplasmin (r = -0.27, p &lt; 0.05) and nitric oxide (r = 0.30, p &lt; 0.05) were observed.	Bilirubin	154-163	superoxide dismutase 1	Homo sapiens	220-223
31926081-5	2020	A significant positive correlation coefficient (r) of blood lead level with lipid peroxide (r = 0.44, p &lt; 0.001), uric acid (r = 0.33 p &lt; 0.05) and bilirubin (r = 0.35, p &lt; 0.05) and a negative correlation with SOD (r = -0.32, p &lt; 0.05), catalase (r = -0.33, p &lt; 0.05), ceruloplasmin (r = -0.27, p &lt; 0.05) and nitric oxide (r = 0.30, p &lt; 0.05) were observed.	Bilirubin	154-163	catalase	Homo sapiens	250-258
31926081-5	2020	A significant positive correlation coefficient (r) of blood lead level with lipid peroxide (r = 0.44, p &lt; 0.001), uric acid (r = 0.33 p &lt; 0.05) and bilirubin (r = 0.35, p &lt; 0.05) and a negative correlation with SOD (r = -0.32, p &lt; 0.05), catalase (r = -0.33, p &lt; 0.05), ceruloplasmin (r = -0.27, p &lt; 0.05) and nitric oxide (r = 0.30, p &lt; 0.05) were observed.	Bilirubin	154-163	ceruloplasmin	Homo sapiens	285-298
31664855-5	2020	The production of cleaved IL-1B and the activation of caspase-1 in LPS- and ATP-primed macrophages were inhibited by hemin, an HO-1 inducer, and two HO-1 enzymatic products [bilirubin and carbon monoxide (CO)].	Bilirubin	174-183	interleukin 1 beta	Mus musculus	26-31
31664855-5	2020	The production of cleaved IL-1B and the activation of caspase-1 in LPS- and ATP-primed macrophages were inhibited by hemin, an HO-1 inducer, and two HO-1 enzymatic products [bilirubin and carbon monoxide (CO)].	Bilirubin	174-183	caspase 1	Mus musculus	54-63
31664855-5	2020	The production of cleaved IL-1B and the activation of caspase-1 in LPS- and ATP-primed macrophages were inhibited by hemin, an HO-1 inducer, and two HO-1 enzymatic products [bilirubin and carbon monoxide (CO)].	Bilirubin	174-183	heme oxygenase 1	Mus musculus	149-153
31664855-9	2020	Taken together, these finding point to a pivotal role for HO-1 in the control of baseline and hypoxic inflammasome signaling, perhaps through the antioxidant properties of bilirubin and CO"s pleiotropic effects.	Bilirubin	172-181	heme oxygenase 1	Mus musculus	58-62
31505104-0	2020	Albumin-bilirubin grade-based nomogram of the BCLC system for personalized prognostic prediction in hepatocellular carcinoma.	Bilirubin	8-17	albumin	Homo sapiens	0-7
33016915-6	2020	The beneficial roles of HO-1 overexpression in AD brains are widely accepted due to its ability to convert pro-oxidant heme to biliverdin and bilirubin (antioxidants), which promote restoration of a suitable tissue redox microenvironment.	Bilirubin	142-151	heme oxygenase 1	Homo sapiens	24-28
31499130-6	2020	In hepatitis B flare patients, the frequency of HBV core-specific TNF-alpha producing CD4 T cells was positively correlated with patients" ALT and total bilirubin level, and the frequency of those cells changed in parallel with the severity of liver damage.	Bilirubin	153-162	tumor necrosis factor	Homo sapiens	66-75
31796680-4	2020	Bilirubin activated the activities of several protein kinases (GSK-3beta, CDK5, and JNK), which were positively correlated with hyperphosphorylated tau; simultaneously increased the expression of AbetaPP gamma-secretase PS2 and decreased the expression of alpha-secretase ADAM17, which were positively correlated with Abeta production.	Bilirubin	0-9	glycogen synthase kinase 3 beta	Rattus norvegicus	63-72
31796680-4	2020	Bilirubin activated the activities of several protein kinases (GSK-3beta, CDK5, and JNK), which were positively correlated with hyperphosphorylated tau; simultaneously increased the expression of AbetaPP gamma-secretase PS2 and decreased the expression of alpha-secretase ADAM17, which were positively correlated with Abeta production.	Bilirubin	0-9	cyclin-dependent kinase 5	Rattus norvegicus	74-78
31796680-4	2020	Bilirubin activated the activities of several protein kinases (GSK-3beta, CDK5, and JNK), which were positively correlated with hyperphosphorylated tau; simultaneously increased the expression of AbetaPP gamma-secretase PS2 and decreased the expression of alpha-secretase ADAM17, which were positively correlated with Abeta production.	Bilirubin	0-9	mitogen-activated protein kinase 8	Rattus norvegicus	84-87
31796680-4	2020	Bilirubin activated the activities of several protein kinases (GSK-3beta, CDK5, and JNK), which were positively correlated with hyperphosphorylated tau; simultaneously increased the expression of AbetaPP gamma-secretase PS2 and decreased the expression of alpha-secretase ADAM17, which were positively correlated with Abeta production.	Bilirubin	0-9	ADAM metallopeptidase domain 17	Rattus norvegicus	272-278
33622990-2	2020	This polymorphism leads to 30% of normal rate transcription initiation of UGT1A1 gene, thus decreasing the bilirubin glucuronidation.	Bilirubin	107-116	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	74-80
31505104-2	2020	We aimed to develop and validate an albumin-bilirubin (ALBI) grade-based nomogram of BCLC to estimate survival for individual HCC patient.	Bilirubin	44-53	albumin	Homo sapiens	36-43
31342573-6	2020	The transplanted pHSCs underwent maturation in vivo to restore the deficient metabolic hepatic function (bilirubin glucuronidation by UGT1A1).	Bilirubin	105-114	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	134-140
31753385-1	2020	Functional chitosan/graphene oxide (CS/GO) composite aerogel microspheres were fabricated via CO2 supercritical drying, which displayed excellent performance for bilirubin removal.	Bilirubin	162-171	citrate synthase	Homo sapiens	36-38
31753385-4	2020	Besides, the adsorption mechanism of bilirubin by the CS/GO composite aerogel microspheres was investigated through the relevant model fitting, including adsorption kinetics and adsorption isotherm, which illustrated that the mechanism included both physical and chemical processes, but chemical adsorption was dominated.	Bilirubin	37-46	citrate synthase	Homo sapiens	54-56
31351160-5	2019	Increased Nrf2 transcriptional activity also leads to activation of haem oxygenase-1, which is associated with upregulation of bilirubin, biliverdin and biliverdin reductase as well as increased carbon monoxide signalling, anti-inflammatory and antioxidant activity.	Bilirubin	127-136	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
32237326-1	2020	The bilirubin metabolism mediated by the phase II metabolizing enzyme UGT1A1 in the liver was evaluated to study the potential hepatotoxicity risk based on investigation on the inhibitory effect of rhein and its metabolites on the UGT1A1 enzyme in Rhei Radix et Rhizoma.	Bilirubin	4-13	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	70-76
31888626-14	2019	DISCUSSION: We anticipate that IV administration of C1-INH will significantly inhibit complement mediated hemolysis in dogs with intravascular IMHA, as determined by blood biomarker measurements (decreased plasma hemoglobin, LDH and bilirubin, increased haptoglobin).	Bilirubin	233-242	serpin family G member 1	Homo sapiens	52-58
31455680-5	2019	Higher bilirubin was associated with decreased sorafenib N-oxide and glucuronide CL/f (P = 1e-4).	Bilirubin	7-16	crystallin gamma F, pseudogene	Homo sapiens	87-95
31949468-9	2019	The injection of CCl4 to the rats induced various alterations such as the increase of relative liver weight, serum alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, total bilirubin, direct bilirubin, triglycerides, very low-density lipoproteins, total cholesterol (slight increase), creatinine, urea, uric acid, and malondialdehyde.	Bilirubin	197-206	C-C motif chemokine ligand 4	Rattus norvegicus	17-21
31949468-9	2019	The injection of CCl4 to the rats induced various alterations such as the increase of relative liver weight, serum alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, total bilirubin, direct bilirubin, triglycerides, very low-density lipoproteins, total cholesterol (slight increase), creatinine, urea, uric acid, and malondialdehyde.	Bilirubin	215-224	C-C motif chemokine ligand 4	Rattus norvegicus	17-21
31819648-7	2019	Furthermore, preoperative bilirubin level was related with R0 resection, lymph node metastasis, TNM stage and postoperative liver function recovery.	Bilirubin	26-35	teneurin transmembrane protein 1	Homo sapiens	96-99
31704097-2	2019	Here, we report that inhibition of biliverdin reductase (BVR), the enzyme of the heme degradation pathway converting biliverdin to bilirubin, shifts endothelial phenotype of the primary human aortic endothelial cells (HAECs) to mesenchymal-like one.	Bilirubin	131-140	biliverdin reductase A	Homo sapiens	35-55
31704097-2	2019	Here, we report that inhibition of biliverdin reductase (BVR), the enzyme of the heme degradation pathway converting biliverdin to bilirubin, shifts endothelial phenotype of the primary human aortic endothelial cells (HAECs) to mesenchymal-like one.	Bilirubin	131-140	biliverdin reductase A	Homo sapiens	57-60
31704097-6	2019	Treatment of BVR-deficient cells with bilirubin does not rescue the endothelial phenotype of HAECs.	Bilirubin	38-47	biliverdin reductase A	Homo sapiens	13-16
31537107-12	2019	Alanine aminotransferase increases to &gt;= 3 x the upper limit of normal in the two ubrogepant cases (possibly or probably related) were transient and resolved with continued dosing; both cases were asymptomatic, with no concurrent bilirubin elevation.	Bilirubin	233-242	glutamic--pyruvic transaminase	Homo sapiens	0-24
31806407-10	2019	Both serum bilirubin and albumin showed significant weak correlation with miRNA-885-5p (r = 0.42, p = 0.001) and (r = -0.27, p = 0.04), respectively but no such correlation was observed with serum miRNA-21.	Bilirubin	11-20	microRNA 21	Homo sapiens	197-205
31771519-20	2019	Bilirubin levels may become elevated as a result of heme oxygenase-1 activation, occurring in exercise-induced acute kidney injury in patients with RHUC; this phenomenon suggests renal ischemia-reperfusion injury.	Bilirubin	0-9	heme oxygenase 1	Homo sapiens	52-68
31711490-5	2019	Peripheral administration of sHDL to Npc1 I1061T homozygous mice mobilizes cholesterol, reduces serum bilirubin, reduces liver macrophage size, and corrects body weight deficits.	Bilirubin	102-111	NPC intracellular cholesterol transporter 1	Mus musculus	37-41
31730632-6	2019	This experimental procedure showed that the in silico conjugation capacities of other mutant UGT1A1s with bilirubin or SN-38 were similar to reported in vitro conjugation capacities.	Bilirubin	106-115	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	93-99
31377640-6	2019	More importantly, PCB-H103 could effectively remove protein-bound toxins including phenol red and bilirubin in bovine serum albumin solution or even in 100% fetal bovine serum (FBS).	Bilirubin	98-107	albumin	Homo sapiens	118-131
31712684-5	2019	The CART model showed that patients lacking HE and with a PT <= 27.8 s and a TBil level <=455 mumol/L experienced less 28-day mortality after ALSS therapy.	Bilirubin	77-81	CART prepropeptide	Homo sapiens	4-8
31520915-6	2019	The results showed that HCM significantly ameliorated the hepatic injury, as evidenced by the attenuation of histopathological changes and the decrease in serum aminotransferase and total bilirubin activities.	Bilirubin	188-197	heterochromatin, multiple chromosomes	Mus musculus	24-27
31730181-18	2019	If time-saving apps, such as the bilirubin app, were implemented widely across institutions and care domains, the potential association with improved patient care and clinician efficiency could be significant.	Bilirubin	33-42	cathepsin B	Homo sapiens	15-19
31772686-9	2019	In line with this, concentrations of circulating miR-143 correlated with markers of organ failure such as creatinine, bilirubin, or lactate in our cohort of critically ill patients.	Bilirubin	118-127	microRNA 143	Homo sapiens	49-56
30939111-2	2019	This experimental study was aimed at exploring whether increasing values of triglycerides, bilirubin or cell-free hemoglobin promote thrombin generation in plasma.	Bilirubin	91-100	coagulation factor II, thrombin	Homo sapiens	133-141
31763029-9	2019	The treatments of TPK, TTK, and TFK reduced the serum total bilirubin (T-Bil), and only TFK treatment reduced the serum alanine aminotransferase (ALT).	Bilirubin	60-69	Ttk protein kinase	Mus musculus	23-26
31680983-0	2019	Cytochrome P450 1A2 Is Incapable of Oxidizing Bilirubin Under Physiological Conditions.	Bilirubin	46-55	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	0-19
31680983-1	2019	Background: Bilirubin (BR) is metabolized mainly by uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) through glucuronidation in the liver.	Bilirubin	12-21	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	52-105
31680983-1	2019	Background: Bilirubin (BR) is metabolized mainly by uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) through glucuronidation in the liver.	Bilirubin	12-21	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	107-113
31680983-1	2019	Background: Bilirubin (BR) is metabolized mainly by uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) through glucuronidation in the liver.	Bilirubin	23-25	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	52-105
31680983-1	2019	Background: Bilirubin (BR) is metabolized mainly by uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) through glucuronidation in the liver.	Bilirubin	23-25	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	107-113
31680983-2	2019	Some studies have shown that several subtypes of cytochrome P450 (CYP) enzymes, including CYP1A2, are upregulated by inducers and proposed to be alternative BR degradation enzymes.	Bilirubin	157-159	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	49-64
31680983-2	2019	Some studies have shown that several subtypes of cytochrome P450 (CYP) enzymes, including CYP1A2, are upregulated by inducers and proposed to be alternative BR degradation enzymes.	Bilirubin	157-159	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	66-69
31680983-2	2019	Some studies have shown that several subtypes of cytochrome P450 (CYP) enzymes, including CYP1A2, are upregulated by inducers and proposed to be alternative BR degradation enzymes.	Bilirubin	157-159	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	90-96
31602166-9	2019	Serum sMR level was positively correlated with MELD score (r s = 0.533, P = 0.001), HBV-DNA level (r s = 0.497, P = 0.022), and TBIL level (r s = 0.894, P < 0.001).	Bilirubin	128-132	LY6/PLAUR domain containing 4	Homo sapiens	6-9
31680983-11	2019	The ability of CYPs to oxidize BR may be triggered by CYP inducers.	Bilirubin	31-33	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	15-18
31619193-1	2019	BACKGROUND: (TA) n repeat sequence (rs8175347) of UGT1A1 gene promoter polymorphism is associated with serum bilirubin levels and gallstones among different sickle cell anaemia (SCA) populations.	Bilirubin	109-118	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	50-56
31619193-13	2019	Although, bilirubin and fetal hemoglobin (HbF) of patients with gallstones were significantly different from those without gallstone, only the serum bilirubin was associated with UGT1A1 (TA) n genotypes on multivariate analysis (p &lt; 0.0001).	Bilirubin	149-158	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	179-185
31422074-3	2019	Biliverdin reductase A (BVRA) reduces biliverdin to the antioxidant bilirubin, which may serve to prevent NAFLD, and possibly the progression to NASH.	Bilirubin	68-77	biliverdin reductase A	Mus musculus	0-22
31195405-0	2019	Caspase-1 involves in bilirubin-induced injury of cultured rat cortical neurons.	Bilirubin	22-31	caspase 1	Rattus norvegicus	0-9
31195405-3	2019	The purpose of this study was to investigate whether caspase-1 is involved in bilirubin-induced neuronal injury.	Bilirubin	78-87	caspase 1	Rattus norvegicus	53-62
31425676-2	2019	In a few instances e.g., neonatal jaundice, overproduction of HO-1 and increased HO activity results in elevated levels of bilirubin requiring clinical intervention with inhibitors of HO activity.	Bilirubin	123-132	heme oxygenase 1	Homo sapiens	62-66
31425676-3	2019	In contrast HO-1 levels and HO activity are low in obesity and the HO system responds to mitigate the deleterious effects of oxidative stress through increased levels of bilirubin (anti-inflammatory) and CO (anti-apoptotic) and decreased levels of heme (pro-oxidant).	Bilirubin	170-179	heme oxygenase 1	Homo sapiens	12-16
31195405-8	2019	CONCLUSION: Bilirubin-induced neuronal injury involves the activation of caspase-1 and NF-kappaB, leading to membrane leakage, independently of IL-1beta and IL-18.	Bilirubin	12-21	caspase 1	Rattus norvegicus	73-82
31195405-8	2019	CONCLUSION: Bilirubin-induced neuronal injury involves the activation of caspase-1 and NF-kappaB, leading to membrane leakage, independently of IL-1beta and IL-18.	Bilirubin	12-21	interleukin 1 beta	Rattus norvegicus	144-152
31146864-4	2019	Here, a new electrochemical sensor based on Au nanoparticles/tetrathiafulvalene-carboxylate functionalized reduced grapheneoxide 0D-2D heterojunction(AuNPs/TTF-COOH/RGO) was fabricated for the discrimination of bilirubin in real human blood.	Bilirubin	211-220	ras homolog family member H	Homo sapiens	156-159
31422074-3	2019	Biliverdin reductase A (BVRA) reduces biliverdin to the antioxidant bilirubin, which may serve to prevent NAFLD, and possibly the progression to NASH.	Bilirubin	68-77	biliverdin reductase A	Mus musculus	24-28
31560476-9	2019	A positive correlation was found between TNF-alpha and NEFA and total bilirubin, significantly more expressed in the control than in experimental group of cows (p(0.01) and it was also found between IL-1alpha and NEFA (p(0.01).	Bilirubin	70-79	tumor necrosis factor	Bos taurus	41-50
31176730-6	2019	MiR-23b levels in plasma inversely correlated with the levels of hemoglobin (Hb), total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) (P &lt; 0.05), but not with rheumatoid factor (RF) or anti-cyclic citrullinated peptide antibodies (ACPA) (P &gt; 0.05).	Bilirubin	88-97	microRNA 23b	Homo sapiens	0-7
31176730-6	2019	MiR-23b levels in plasma inversely correlated with the levels of hemoglobin (Hb), total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) (P &lt; 0.05), but not with rheumatoid factor (RF) or anti-cyclic citrullinated peptide antibodies (ACPA) (P &gt; 0.05).	Bilirubin	99-103	microRNA 23b	Homo sapiens	0-7
31176730-6	2019	MiR-23b levels in plasma inversely correlated with the levels of hemoglobin (Hb), total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) (P &lt; 0.05), but not with rheumatoid factor (RF) or anti-cyclic citrullinated peptide antibodies (ACPA) (P &gt; 0.05).	Bilirubin	113-122	microRNA 23b	Homo sapiens	0-7
31176730-6	2019	MiR-23b levels in plasma inversely correlated with the levels of hemoglobin (Hb), total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) (P &lt; 0.05), but not with rheumatoid factor (RF) or anti-cyclic citrullinated peptide antibodies (ACPA) (P &gt; 0.05).	Bilirubin	113-122	microRNA 23b	Homo sapiens	0-7
30588615-3	2019	Uridine 5"-diphospho-glucuronosyl transferase (UGT)1A1 variants coding for bilirubin UDP-glucuronosyl transferase resulting in mild hyperbilirubinemia (as in Gilbert syndrome (GS)) may confer a strong genetic advantage.	Bilirubin	75-84	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	47-54
30636082-8	2019	The G6PD 1388 G&gt;A, SLCO1B1 rs4149056 and BLVRA rs699512 SNPs had a significant impact on serum total bilirubin levels.	Bilirubin	104-113	glucose-6-phosphate dehydrogenase	Homo sapiens	4-8
30636082-8	2019	The G6PD 1388 G&gt;A, SLCO1B1 rs4149056 and BLVRA rs699512 SNPs had a significant impact on serum total bilirubin levels.	Bilirubin	104-113	solute carrier organic anion transporter family member 1B1	Homo sapiens	22-29
30636082-8	2019	The G6PD 1388 G&gt;A, SLCO1B1 rs4149056 and BLVRA rs699512 SNPs had a significant impact on serum total bilirubin levels.	Bilirubin	104-113	biliverdin reductase A	Homo sapiens	44-49
30636082-10	2019	CONCLUSION: Genetic variants of bilirubin metabolism genes, including G6PD 1388 G&gt;A, SLCO1B1 rs4149056 and BLVRA rs699512, are associated with the risk of neonatal hyperbilirubinaemia, and are potential markers for predicting the disorder.	Bilirubin	32-41	glucose-6-phosphate dehydrogenase	Homo sapiens	70-74
30636082-10	2019	CONCLUSION: Genetic variants of bilirubin metabolism genes, including G6PD 1388 G&gt;A, SLCO1B1 rs4149056 and BLVRA rs699512, are associated with the risk of neonatal hyperbilirubinaemia, and are potential markers for predicting the disorder.	Bilirubin	32-41	solute carrier organic anion transporter family member 1B1	Homo sapiens	88-95
30636082-10	2019	CONCLUSION: Genetic variants of bilirubin metabolism genes, including G6PD 1388 G&gt;A, SLCO1B1 rs4149056 and BLVRA rs699512, are associated with the risk of neonatal hyperbilirubinaemia, and are potential markers for predicting the disorder.	Bilirubin	32-41	biliverdin reductase A	Homo sapiens	110-115
31872743-4	2019	Molecular docking results showed that apigenin was docked into the active region of UGT1 A1 enzyme protein F,consistent with the active region of bilirubin docking,with moderate affinity.	Bilirubin	146-155	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	84-91
31374171-4	2019	Herein, a "nitrogen-protected silica template" method is proposed to design a nanoantioxidant called an organosilica-based hollow mesoporous bilirubin nanoparticle (HMBRN), which can act as an excellent nanocarrier to codeliver GOx and TPZ.	Bilirubin	141-150	hydroxyacid oxidase 1	Homo sapiens	228-231
31429707-7	2019	The serum caspase-1 levels in ACLF patients showed a negative correlation with total serum bilirubin and a positive correlation with serum total protein and albumin.	Bilirubin	91-100	caspase 1	Homo sapiens	10-19
30737551-8	2019	Age, preoperative urea nitrogen (UN) and the preoperative albumin-to-bilirubin index (ALBI) showed the highest area under the curve (AUC) for the discontinuation of S-1 adjuvant within 6 months in each category: body status, blood tests and indices.	Bilirubin	69-78	proteasome 26S subunit, non-ATPase 1	Homo sapiens	165-168
31121485-0	2019	Bilirubin alleviates alum-induced peritonitis through inactivation of NLRP3 inflammasome.	Bilirubin	0-9	NLR family, pyrin domain containing 3	Mus musculus	70-75
31121485-6	2019	Bilirubin prior to LPS treatment decreased protein expressions of Nlrp3, pro-interleukin (IL)-1beta and mature IL-1beta in PMs, whereas bilirubin post LPS treatment showed no effects.	Bilirubin	0-9	NLR family, pyrin domain containing 3	Mus musculus	66-71
31121485-6	2019	Bilirubin prior to LPS treatment decreased protein expressions of Nlrp3, pro-interleukin (IL)-1beta and mature IL-1beta in PMs, whereas bilirubin post LPS treatment showed no effects.	Bilirubin	0-9	interleukin 1 beta	Mus musculus	111-119
31121485-7	2019	Bilirubin prior to LPS treatment dose-dependently repressed expressions of Nlrp3 and IL-1beta, and inhibited translocation of p-p65 to nucleus in Raw264.7 cells.	Bilirubin	0-9	NLR family, pyrin domain containing 3	Mus musculus	75-80
31121485-7	2019	Bilirubin prior to LPS treatment dose-dependently repressed expressions of Nlrp3 and IL-1beta, and inhibited translocation of p-p65 to nucleus in Raw264.7 cells.	Bilirubin	0-9	interleukin 1 beta	Mus musculus	85-93
31121485-7	2019	Bilirubin prior to LPS treatment dose-dependently repressed expressions of Nlrp3 and IL-1beta, and inhibited translocation of p-p65 to nucleus in Raw264.7 cells.	Bilirubin	0-9	lymphocyte cytosolic protein 1	Mus musculus	126-131
31121485-8	2019	Bilirubin treatment decreased myeloperoxidase activity and reduced the levels of inflammatory cytokines (i.e., IL-1beta, TNFalpha and IL-6) in lavage fluid in mice with alum-induced peritonitis.	Bilirubin	0-9	interleukin 1 beta	Mus musculus	111-119
31121485-8	2019	Bilirubin treatment decreased myeloperoxidase activity and reduced the levels of inflammatory cytokines (i.e., IL-1beta, TNFalpha and IL-6) in lavage fluid in mice with alum-induced peritonitis.	Bilirubin	0-9	tumor necrosis factor	Mus musculus	121-129
31121485-8	2019	Bilirubin treatment decreased myeloperoxidase activity and reduced the levels of inflammatory cytokines (i.e., IL-1beta, TNFalpha and IL-6) in lavage fluid in mice with alum-induced peritonitis.	Bilirubin	0-9	interleukin 6	Mus musculus	134-138
31121485-11	2019	In conclusion, bilirubin acted on inflammation and alleviated alum-induced peritonitis through inactivation of Nlrp3 inflammasome.	Bilirubin	15-24	NLR family, pyrin domain containing 3	Mus musculus	111-116
31464928-7	2019	In AIH group, serum galectin-9 levels weakly correlated with alanine aminotransferase levels or total bilirubin (TB) and strongly correlated with C-X-C motif chemokine 10 (CXCL10) and Mac-2 binding protein glycosylation isomer (M2BPGi) levels, but did not correlate with the histological grade of liver fibrosis.	Bilirubin	102-111	galectin 9	Homo sapiens	20-30
31464928-7	2019	In AIH group, serum galectin-9 levels weakly correlated with alanine aminotransferase levels or total bilirubin (TB) and strongly correlated with C-X-C motif chemokine 10 (CXCL10) and Mac-2 binding protein glycosylation isomer (M2BPGi) levels, but did not correlate with the histological grade of liver fibrosis.	Bilirubin	113-115	galectin 9	Homo sapiens	20-30
30938885-8	2019	After BMSCs transplantation with miR-214 inhibition, a decreased expression of ALT, AST, and TBiL yet an increased expression of HGF was shown, coupled with a decline in the expression of caspase 3, TNF-alpha, and IL-10.	Bilirubin	93-97	microRNA 214	Rattus norvegicus	33-40
31339084-0	2021	UGT1A1 mutations and psychoses: towards understanding the relationship with unconjugated bilirubin.	Bilirubin	89-98	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
31366967-2	2019	It is followed by the accumulation of bilirubin, which is a secondary product of the activity of heme oxygenase-1, an enzyme that catalyzes the breakdown of heme released from disrupted erythrocytes and taken up by hepatic macrophages.	Bilirubin	38-47	heme oxygenase 1	Mus musculus	97-113
30874733-9	2019	We reveal strong correlations between total bilirubin and glucagon and GLP-1 levels.	Bilirubin	44-53	glucagon	Homo sapiens	71-76
31344980-1	2019	Heme oxygenase-1 (HO-1) is an intracellular enzyme that catalyzes the oxidation of heme to generate ferrous iron, carbon monoxide (CO), and biliverdin, which is subsequently converted to bilirubin.	Bilirubin	187-196	heme oxygenase 1	Homo sapiens	0-16
31344980-1	2019	Heme oxygenase-1 (HO-1) is an intracellular enzyme that catalyzes the oxidation of heme to generate ferrous iron, carbon monoxide (CO), and biliverdin, which is subsequently converted to bilirubin.	Bilirubin	187-196	heme oxygenase 1	Homo sapiens	18-22
31344980-5	2019	In atherosclerosis, HO-1 may play a protective role against the progression of atherosclerosis, mainly due to the degradation of pro-oxidant heme, the generation of anti-oxidants biliverdin and bilirubin and the production of vasodilator CO.	Bilirubin	194-203	heme oxygenase 1	Homo sapiens	20-24
31410205-0	2019	Circadian Clock Gene Bmal1 Regulates Bilirubin Detoxification: A Potential Mechanism of Feedback Control of Hyperbilirubinemia.	Bilirubin	37-46	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	21-26
31410205-8	2019	Results: We first demonstrated diurnal variations in plasma UCB levels and in main bilirubin-detoxifying genes Ugt1a1 and Mrp2.	Bilirubin	83-92	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	111-117
31410205-8	2019	Results: We first demonstrated diurnal variations in plasma UCB levels and in main bilirubin-detoxifying genes Ugt1a1 and Mrp2.	Bilirubin	83-92	prolactin family 2, subfamily c, member 3	Mus musculus	122-126
31410205-10	2019	Bmal1 ablation abrogated the circadian rhythms of UCB and bilirubin-induced hepatotoxicity in mice.	Bilirubin	58-67	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	0-5
31410205-13	2019	Further, Bmal1 ablation caused a loss of circadian time-dependency in bilirubin clearance and sensitized mice to chemical induced-hyperbilirubinemia.	Bilirubin	70-79	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	9-14
31410205-14	2019	Moreover, bilirubin stimulated Bmal1 expression through antagonism of Rev-erbalpha, constituting a feedback mechanism in bilirubin detoxification.	Bilirubin	10-19	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	31-36
31410205-14	2019	Moreover, bilirubin stimulated Bmal1 expression through antagonism of Rev-erbalpha, constituting a feedback mechanism in bilirubin detoxification.	Bilirubin	10-19	nuclear receptor subfamily 1, group D, member 1	Mus musculus	70-82
31410205-14	2019	Moreover, bilirubin stimulated Bmal1 expression through antagonism of Rev-erbalpha, constituting a feedback mechanism in bilirubin detoxification.	Bilirubin	121-130	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	31-36
31410205-14	2019	Moreover, bilirubin stimulated Bmal1 expression through antagonism of Rev-erbalpha, constituting a feedback mechanism in bilirubin detoxification.	Bilirubin	121-130	nuclear receptor subfamily 1, group D, member 1	Mus musculus	70-82
31410205-15	2019	Conclusion: These data supported a dual role for circadian clock in regulation of bilirubin detoxification, generating circadian variations in bilirubin level via direct transactivation of detoxifying genes Ugt1a1 and Mrp2, and defending the body against hyperbilirubinemia via Rev-erbalpha antagonism.	Bilirubin	82-91	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	207-213
31410205-15	2019	Conclusion: These data supported a dual role for circadian clock in regulation of bilirubin detoxification, generating circadian variations in bilirubin level via direct transactivation of detoxifying genes Ugt1a1 and Mrp2, and defending the body against hyperbilirubinemia via Rev-erbalpha antagonism.	Bilirubin	82-91	prolactin family 2, subfamily c, member 3	Mus musculus	218-222
31410205-15	2019	Conclusion: These data supported a dual role for circadian clock in regulation of bilirubin detoxification, generating circadian variations in bilirubin level via direct transactivation of detoxifying genes Ugt1a1 and Mrp2, and defending the body against hyperbilirubinemia via Rev-erbalpha antagonism.	Bilirubin	82-91	nuclear receptor subfamily 1, group D, member 1	Mus musculus	278-290
31410205-15	2019	Conclusion: These data supported a dual role for circadian clock in regulation of bilirubin detoxification, generating circadian variations in bilirubin level via direct transactivation of detoxifying genes Ugt1a1 and Mrp2, and defending the body against hyperbilirubinemia via Rev-erbalpha antagonism.	Bilirubin	143-152	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	207-213
31410205-15	2019	Conclusion: These data supported a dual role for circadian clock in regulation of bilirubin detoxification, generating circadian variations in bilirubin level via direct transactivation of detoxifying genes Ugt1a1 and Mrp2, and defending the body against hyperbilirubinemia via Rev-erbalpha antagonism.	Bilirubin	143-152	prolactin family 2, subfamily c, member 3	Mus musculus	218-222
31410205-15	2019	Conclusion: These data supported a dual role for circadian clock in regulation of bilirubin detoxification, generating circadian variations in bilirubin level via direct transactivation of detoxifying genes Ugt1a1 and Mrp2, and defending the body against hyperbilirubinemia via Rev-erbalpha antagonism.	Bilirubin	143-152	nuclear receptor subfamily 1, group D, member 1	Mus musculus	278-290
31115300-6	2019	Albumin-bilirubin scores were calculated according to the following equation: (log10 total bilirubin [T-Bil] x 0.66) + (albumin [Alb] x -0.085).	Bilirubin	8-17	albumin	Homo sapiens	0-3
31115300-6	2019	Albumin-bilirubin scores were calculated according to the following equation: (log10 total bilirubin [T-Bil] x 0.66) + (albumin [Alb] x -0.085).	Bilirubin	91-100	albumin	Homo sapiens	0-3
31396090-3	2019	Heme oxygenase (HO) -1 can catabolize free heme into carbon monoxide (CO), ferrous iron, and biliverdin (BV)/bilirubin (BR).	Bilirubin	109-118	heme oxygenase 1	Homo sapiens	0-22
31017737-7	2019	Among the 178 patients of Gilbert"s syndrome, serum bilirubin value was inversely correlated with UGT1A1 activity (r = -.306, P &lt; .001).	Bilirubin	52-61	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	98-104
30578715-8	2019	sPD-1 concentration was associated with HBV markers (HBsAg, HBV DNA and HBeAg) and biochemical parameters (serum aspartate aminotransferase [AST], alanine aminotransferase [ALT], total bilirubin [TBil] and gamma glutamyl transferase [gamma-GT] levels) (all P < 0.05).	Bilirubin	185-194	homeobox D13	Homo sapiens	0-5
30578715-8	2019	sPD-1 concentration was associated with HBV markers (HBsAg, HBV DNA and HBeAg) and biochemical parameters (serum aspartate aminotransferase [AST], alanine aminotransferase [ALT], total bilirubin [TBil] and gamma glutamyl transferase [gamma-GT] levels) (all P < 0.05).	Bilirubin	196-200	homeobox D13	Homo sapiens	0-5
31017737-9	2019	Our results demonstrate that UGT1A1 activity is certainly a determinate for serum bilirubin value and UGT1A1 activity  40% of normal is a proper risk factor for the development of Gilbert"s syndrome.	Bilirubin	82-91	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	29-35
30943888-2	2019	Our primary objective of the study was to compare serum bilirubin levels at 48 h and 96 h of age in neonates with and without ABO incompatibility.	Bilirubin	56-65	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	126-129
30943888-7	2019	Late preterm and term neonates with and without ABO incompatibility have similar bilirubin levels and no increased risk of significant hyperbilirubinemia.	Bilirubin	81-90	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	48-51
30771456-6	2019	RESULTS: Compared with controls, VEGF-C perfusion reduced ALT and TBIL levels and alleviated liver damage.	Bilirubin	66-70	vascular endothelial growth factor C	Rattus norvegicus	33-39
30976847-11	2019	Compared to the LRP6(+/+) wild-type mice, the LRP6(+/-) knockdown mice had lower ALT, TBIL, TBA, and ALB/GLO values, as well reduced liver tissue damage, in accordance with their reduced expressions of LRP6, beta-catenin, and CYP2E1.	Bilirubin	86-90	low density lipoprotein receptor-related protein 6	Mus musculus	46-50
30976847-11	2019	Compared to the LRP6(+/+) wild-type mice, the LRP6(+/-) knockdown mice had lower ALT, TBIL, TBA, and ALB/GLO values, as well reduced liver tissue damage, in accordance with their reduced expressions of LRP6, beta-catenin, and CYP2E1.	Bilirubin	86-90	low density lipoprotein receptor-related protein 6	Mus musculus	46-50
31186786-8	2019	The expression level of serum TGF-beta was closely related to total bilirubin, ascites, TNM stage, prothrombin time and tumor diameter.	Bilirubin	68-77	transforming growth factor beta 1	Homo sapiens	30-38
29295636-1	2019	OBJECTIVE: Unconjugated bilirubin (UCB) may cause neurotoxicity in preterm neonates due to immaturity of UGT1A1 leading to bilirubin accumulation in the brain.	Bilirubin	24-33	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	105-111
29295636-1	2019	OBJECTIVE: Unconjugated bilirubin (UCB) may cause neurotoxicity in preterm neonates due to immaturity of UGT1A1 leading to bilirubin accumulation in the brain.	Bilirubin	123-132	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	105-111
31359665-1	2019	To evaluate the hepatotoxicity risks of physcion on the basis of the bilirubin metabolism mediated by glucuronidation of UDP-glucuronosyltransferases 1A1(UGT1A1 enzyme).	Bilirubin	69-78	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	154-160
31359665-2	2019	The monomers were added into the rat liver microsomes to test the hepatotoxicity by using bilirubin as UGT1A1 enzyme substrate, with apparent inhibition constant K_i as the evaluation index.	Bilirubin	90-99	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	103-109
31156336-0	2019	Plasma Cathepsin S is Associated with High-density Lipoprotein Cholesterol and Bilirubin in Patients with Abdominal Aortic Aneurysms.	Bilirubin	79-88	cathepsin S	Homo sapiens	7-18
31074682-0	2019	RNA sequencing in human HepG2 hepatocytes reveals PPAR-alpha mediates transcriptome responsiveness of bilirubin.	Bilirubin	102-111	peroxisome proliferator activated receptor alpha	Homo sapiens	50-60
31074682-3	2019	Using RNA sequencing, we found that biliverdin, which is rapidly reduced to bilirubin, induced transcriptome responses in human HepG2 hepatocytes in a peroxisome proliferator-activated receptor (PPAR)-alpha-dependent fashion (398 genes with >2-fold change; false discovery rate P < 0.05).	Bilirubin	76-85	peroxisome proliferator activated receptor alpha	Homo sapiens	151-206
31074682-5	2019	Gene set enrichment analysis revealed the bilirubin-PPAR-alpha transcriptome mediates pathways for oxidation-reduction processes, mitochondrial function, response to nutrients, fatty acid oxidation, and lipid homeostasis.	Bilirubin	42-51	peroxisome proliferator activated receptor alpha	Homo sapiens	52-62
31074682-6	2019	Together, these findings suggest that transcriptome responses from the generation of bilirubin are mostly PPAR-alpha dependent, and its antioxidant function regulates a smaller set of genes.	Bilirubin	85-94	peroxisome proliferator activated receptor alpha	Homo sapiens	106-116
30967260-4	2019	Our previous studies suggested that impaired inactivation of digestive proteases by deconjugated bilirubin in experimental colitis, thus bacterial beta-glucuronidase for catalyzing the reaction, may have played critical role in the pathogenesis of IBD.	Bilirubin	97-106	glucuronidase, beta	Mus musculus	147-165
31142299-5	2019	CONCLUSION: In newly diagnosed CNs patients with unconjugated bilirubin levels consistent with CNs type II but that are unresponsive to phenobarbital treatment, disruption of the HNF-1alpha binding site in the proximal promoter should be considered as a probable cause.	Bilirubin	62-71	HNF1 homeobox A	Homo sapiens	179-189
31156336-6	2019	In the patients with AAA, the plasma CTSS was correlated with HDL-C (r = -0.377, p = 0.034) and total bilirubin (r =0.500, p = 0.003) while, unexpectedly, it was not correlated with cystatin C (Cys C) (r =0.083, p = 0.652).	Bilirubin	102-111	cathepsin S	Homo sapiens	37-41
31156336-9	2019	Conclusions: These results provide the first evidence that CTSS negatively correlated with HDL-C and bilirubin in patients with AAA.	Bilirubin	101-110	cathepsin S	Homo sapiens	59-63
30633816-13	2019	Loss of AQP2 in AKI patients with elevated bilirubin and CN might be the result of toxic effects of cholestasis and in part be responsible for the impairment of renal function.	Bilirubin	43-52	aquaporin 2	Homo sapiens	8-12
31065010-3	2019	Extending these previous findings, here we show that TLR4-SI expression post-CPB was associated with low serum bilirubin and reduced preoperative expression of biliverdin reductase A (BVRA), the enzyme that converts biliverdin to bilirubin, in patient"s leukocytes.	Bilirubin	111-120	toll like receptor 4	Homo sapiens	53-57
31065010-3	2019	Extending these previous findings, here we show that TLR4-SI expression post-CPB was associated with low serum bilirubin and reduced preoperative expression of biliverdin reductase A (BVRA), the enzyme that converts biliverdin to bilirubin, in patient"s leukocytes.	Bilirubin	230-239	toll like receptor 4	Homo sapiens	53-57
31065010-3	2019	Extending these previous findings, here we show that TLR4-SI expression post-CPB was associated with low serum bilirubin and reduced preoperative expression of biliverdin reductase A (BVRA), the enzyme that converts biliverdin to bilirubin, in patient"s leukocytes.	Bilirubin	230-239	biliverdin reductase A	Homo sapiens	160-182
31065010-3	2019	Extending these previous findings, here we show that TLR4-SI expression post-CPB was associated with low serum bilirubin and reduced preoperative expression of biliverdin reductase A (BVRA), the enzyme that converts biliverdin to bilirubin, in patient"s leukocytes.	Bilirubin	230-239	biliverdin reductase A	Homo sapiens	184-188
30623621-12	2019	The presence of anti-p62 was associated with higher levels of bilirubin and alkaline phosphatase (P&lt;0.001).	Bilirubin	62-71	nucleoporin 62	Homo sapiens	21-24
30684573-0	2019	Characterisation and the effects of bilirubin binding to human fibrinogen.	Bilirubin	36-45	fibrinogen beta chain	Homo sapiens	63-73
30684573-4	2019	The present paper describes interaction between fibrinogen and bilirubin, and the influence of bilirubin on the formation of fibrin and protection against oxidation.	Bilirubin	63-72	fibrinogen beta chain	Homo sapiens	48-58
30684573-5	2019	The binding constant of 4.5 x 104 M-1 was determined for the fibrinogen/bilirubin complex at 37  C. There is no change in secondary and tertiary structure of fibrinogen or its thermal stability upon bilirubin binding.	Bilirubin	72-81	fibrinogen beta chain	Homo sapiens	61-71
30684573-6	2019	The binding site of fibrinogen is not stereospecific for bilirubin and is able to accommodate both bilirubin conformers.	Bilirubin	57-66	fibrinogen beta chain	Homo sapiens	20-30
30684573-6	2019	The binding site of fibrinogen is not stereospecific for bilirubin and is able to accommodate both bilirubin conformers.	Bilirubin	99-108	fibrinogen beta chain	Homo sapiens	20-30
30684573-7	2019	A change in absorption maximum of bilirubin occurs upon its interaction with fibrinogen, suggesting an alteration in the conformation of bilirubin to the more cyclic one.	Bilirubin	34-43	fibrinogen beta chain	Homo sapiens	77-87
30684573-7	2019	A change in absorption maximum of bilirubin occurs upon its interaction with fibrinogen, suggesting an alteration in the conformation of bilirubin to the more cyclic one.	Bilirubin	137-146	fibrinogen beta chain	Homo sapiens	77-87
30684573-8	2019	Bilirubin exerts antioxidant effect on fibrinogen, preventing its carbonylation and aggregation.	Bilirubin	0-9	fibrinogen beta chain	Homo sapiens	39-49
30684573-10	2019	Fibrinogen and bilirubin interact at physiological concentrations, bilirubin may act as an antioxidant for fibrinogen and may modulate an important event in haemostasis, which altogether suggests possible physiological relevance of this interaction.	Bilirubin	15-24	fibrinogen beta chain	Homo sapiens	107-117
30684573-10	2019	Fibrinogen and bilirubin interact at physiological concentrations, bilirubin may act as an antioxidant for fibrinogen and may modulate an important event in haemostasis, which altogether suggests possible physiological relevance of this interaction.	Bilirubin	67-76	fibrinogen beta chain	Homo sapiens	0-10
30684573-10	2019	Fibrinogen and bilirubin interact at physiological concentrations, bilirubin may act as an antioxidant for fibrinogen and may modulate an important event in haemostasis, which altogether suggests possible physiological relevance of this interaction.	Bilirubin	67-76	fibrinogen beta chain	Homo sapiens	107-117
30952817-1	2019	Biliverdin reductase (BVR)-A is a pleotropic enzyme converting biliverdin to bilirubin and a signaling molecule that has cytoprotective and immunomodulatory effects.	Bilirubin	77-86	biliverdin reductase A	Mus musculus	0-28
31069991-4	2019	Hyperbilirubinemia can also be caused by impaired bilirubin conjugation due to polymorphisms and mutations in genes involved in bilirubin metabolism (eg, UGT1A1).	Bilirubin	5-14	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	154-160
31069991-4	2019	Hyperbilirubinemia can also be caused by impaired bilirubin conjugation due to polymorphisms and mutations in genes involved in bilirubin metabolism (eg, UGT1A1).	Bilirubin	50-59	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	154-160
32341967-10	2019	EPO preserved hepatic enzymes and total bilirubin in the treated group.	Bilirubin	40-49	erythropoietin	Rattus norvegicus	0-3
30812990-0	2019	Red emitting human serum albumin templated copper nanoclusters as effective candidates for highly specific biosensing of bilirubin.	Bilirubin	121-130	albumin	Homo sapiens	19-32
30812990-1	2019	In this paper, we report a new type of human serum albumin (HSA) stabilized red emissive copper nanoclusters (HSA-CuNCs) were prepared at room temperature and HSA-CuNCs were applied to identify the bilirubin in human urine and blood serum samples.	Bilirubin	198-207	albumin	Homo sapiens	45-58
30594625-2	2019	Recent studies demonstrate that some natural flavonoids are potent inhibitors of the human UDP-glucuronosyltransferase 1A1 (UGT1A1), a key enzyme in detoxification of endogenous harmful compounds such as bilirubin.	Bilirubin	204-213	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	91-122
31008491-6	2019	Recent studies have shown that PXR activation can regulate glucose metabolism, lipid metabolism, steroid endocrine homeostasis, detoxification of cholic acid and bilirubin, bone mineral balance, and immune inflammation in vivo.	Bilirubin	162-171	nuclear receptor subfamily 1 group I member 2	Homo sapiens	31-34
30784878-3	2019	Under these conditions, HO-1 exerts its strong cytoprotective activities and plays a crucial role in stimulating cell survival by removing the pro-oxidant heme and by producing carbon monoxide and biliverdin (promptly reduced to bilirubin).	Bilirubin	229-238	heme oxygenase 1	Homo sapiens	24-28
31090040-9	2019	Moreover, the concentration of AT negatively correlated with INR, aspartate aminotransferase, and total and conjugated bilirubin levels.	Bilirubin	119-128	serpin family C member 1	Homo sapiens	31-33
30896150-7	2019	The recovered PL intensity of the developed BR assay kit, which was monitored by integrated smartphone camera, was linearly proportional to the concentration of BR in the range of 2-20 mg dL-1.	Bilirubin	44-46	l(1)L1	Drosophila melanogaster	188-192
30988277-9	2019	High expression of miR-196a or miR-196b was correlated with tumor size, tumor-node-metastasis stage, lymph node metastasis, albumin-bilirubin grade and poor 5-year survival.	Bilirubin	132-141	microRNA 196b	Homo sapiens	31-39
30594625-7	2019	Furthermore, docking simulations showed that the binding areas of NHPN, kaempferol and acacetin on UGT1A1 were highly overlapping, and convergence with the binding area of bilirubin within UGT1A1.	Bilirubin	172-181	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	99-105
30594625-7	2019	Furthermore, docking simulations showed that the binding areas of NHPN, kaempferol and acacetin on UGT1A1 were highly overlapping, and convergence with the binding area of bilirubin within UGT1A1.	Bilirubin	172-181	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	189-195
30594625-2	2019	Recent studies demonstrate that some natural flavonoids are potent inhibitors of the human UDP-glucuronosyltransferase 1A1 (UGT1A1), a key enzyme in detoxification of endogenous harmful compounds such as bilirubin.	Bilirubin	204-213	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	124-130
30877033-0	2019	Modulation of Cav2.3 channels by unconjugated bilirubin (UCB) - Candidate mechanism for UCB-induced neuromodulation and neurotoxicity.	Bilirubin	46-55	calcium channel, voltage-dependent, R type, alpha 1E subunit	Mus musculus	14-20
30915406-8	2019	Additionally, serum glypican-3 was associated with liver stiffness and serum total bilirubin (p &lt; 0.001, respectively).	Bilirubin	83-92	glypican 3	Homo sapiens	20-30
31061956-6	2019	Spearman correlations of change of an immune marker from baseline to day 90 with change in serum bilirubin revealed that an increase in total bilirubin correlated with 1) increased percentage of HLA-DR+CD38+ NK cells and expression of NK cell activation markers CD69 and HLA-DR, 2) decreased percentage of regulatory T cells, and 3) increased interleukin (IL)-8 and associated neutrophil products (elastase and neutrophil extracellular traps).	Bilirubin	97-106	CD38 molecule	Homo sapiens	202-206
31061956-6	2019	Spearman correlations of change of an immune marker from baseline to day 90 with change in serum bilirubin revealed that an increase in total bilirubin correlated with 1) increased percentage of HLA-DR+CD38+ NK cells and expression of NK cell activation markers CD69 and HLA-DR, 2) decreased percentage of regulatory T cells, and 3) increased interleukin (IL)-8 and associated neutrophil products (elastase and neutrophil extracellular traps).	Bilirubin	142-151	CD38 molecule	Homo sapiens	202-206
31061956-6	2019	Spearman correlations of change of an immune marker from baseline to day 90 with change in serum bilirubin revealed that an increase in total bilirubin correlated with 1) increased percentage of HLA-DR+CD38+ NK cells and expression of NK cell activation markers CD69 and HLA-DR, 2) decreased percentage of regulatory T cells, and 3) increased interleukin (IL)-8 and associated neutrophil products (elastase and neutrophil extracellular traps).	Bilirubin	142-151	CD69 molecule	Homo sapiens	262-266
31061956-6	2019	Spearman correlations of change of an immune marker from baseline to day 90 with change in serum bilirubin revealed that an increase in total bilirubin correlated with 1) increased percentage of HLA-DR+CD38+ NK cells and expression of NK cell activation markers CD69 and HLA-DR, 2) decreased percentage of regulatory T cells, and 3) increased interleukin (IL)-8 and associated neutrophil products (elastase and neutrophil extracellular traps).	Bilirubin	142-151	C-X-C motif chemokine ligand 8	Homo sapiens	343-361
30997121-0	2019	Does elevated bilirubin aid weight control by preventing development of hypothalamic leptin resistance?	Bilirubin	14-23	activation induced cytidine deaminase	Homo sapiens	24-27
30862875-4	2019	We show that Tnfr1-/-/Mdr2-/- mice displayed increased plasma levels of ALT, ALP, and bilirubin as well as a significantly higher collagen content, and markers of fibrosis than Mdr2-/- mice.	Bilirubin	86-95	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	13-18
30862875-4	2019	We show that Tnfr1-/-/Mdr2-/- mice displayed increased plasma levels of ALT, ALP, and bilirubin as well as a significantly higher collagen content, and markers of fibrosis than Mdr2-/- mice.	Bilirubin	86-95	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	22-26
30783454-8	2019	Spearman analysis demonstrated that serum miR-1273g-3p levels were significantly positively correlated with age, body mass index, alanine aminotransferase, AST and total bilirubin (all P&lt;0.05), and negatively correlated with PLT (P&lt;0.05).	Bilirubin	170-179	MLX interacting protein	Homo sapiens	42-45
29513159-0	2019	Elucidating the interaction of ticlopidine with serum albumin and its role in bilirubin displacement in vitro.	Bilirubin	78-87	albumin	Homo sapiens	54-61
29513159-9	2019	Ticlopidine was found to displace bilirubin from serum albumin.	Bilirubin	34-43	albumin	Homo sapiens	55-62
29513159-10	2019	Moreover, the binding constant of bilirubin-serum albumin interaction also decreased in presence of ticlopidine.	Bilirubin	34-43	albumin	Homo sapiens	50-57
29882088-9	2019	The correlation between the expression of ACE2 and TBil, also the Scr level were investigated.	Bilirubin	51-55	angiotensin I converting enzyme 2	Rattus norvegicus	42-46
29882088-12	2019	The relationship between the mRNA expression of ACE2 and TBil/Scr was observed to be moderately negatively correlated (r = -0.516, R2 = 0.292, P &lt; 0.01), (r = -0.576, R2 = 0.332, P &lt; 0.01), respectively.	Bilirubin	57-61	angiotensin I converting enzyme 2	Rattus norvegicus	48-52
30414214-6	2019	The TPAR-NL exhibited profound antihepatotoxic effect in mice pretreated with carbon tetrachloride (CCl4 ) via reduction of serum alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels compared with free TPAR.	Bilirubin	194-203	chemokine (C-C motif) ligand 4	Mus musculus	100-104
30859103-20	2019	Notably miR-122 correlated significantly with increased bilirubin levels in the EtOH with LI group (p &lt; 0.05).	Bilirubin	56-65	microRNA 122	Homo sapiens	8-15
30820183-7	2019	Pretreatment levels of ferritin and bilirubin were associated with the presence of UGT1A1*28 genotype, indicating its potential as a predictive marker.	Bilirubin	36-45	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	83-89
31061955-10	2019	Serum IL-33 levels were positively correlated with serum total bilirubin (TB), alanine aminotransferase (ALT), and necroinflammatory activity in AIH.	Bilirubin	63-72	interleukin 33	Homo sapiens	6-11
31061955-10	2019	Serum IL-33 levels were positively correlated with serum total bilirubin (TB), alanine aminotransferase (ALT), and necroinflammatory activity in AIH.	Bilirubin	74-76	interleukin 33	Homo sapiens	6-11
30070713-10	2019	In addition, bilirubin in the ALB cohort increased, whereas it decreased in the NOALB cohort.	Bilirubin	13-22	albumin	Homo sapiens	30-33
30937309-5	2019	A novel model, ATPI, including aspartate aminotransferase (AST), total bilirubin (TBil), and platelets (PLT), was developed in training cohort.	Bilirubin	71-80	ATP synthase inhibitory factor subunit 1	Homo sapiens	15-19
30937309-5	2019	A novel model, ATPI, including aspartate aminotransferase (AST), total bilirubin (TBil), and platelets (PLT), was developed in training cohort.	Bilirubin	82-86	ATP synthase inhibitory factor subunit 1	Homo sapiens	15-19
30605610-3	2019	As one of antioxidant defense systems, heme oxygenase-1 (HO-1) acts as an essential role in tumor development by offering antioxidant bilirubin to protect cancer cells under stress conditions.	Bilirubin	134-143	heme oxygenase 1	Homo sapiens	39-55
30863165-11	2019	The potential predictive prognostic factors in the DEB-TACE group were tumor response, APS grading, and serum bilirubin.	Bilirubin	110-119	ADAM metallopeptidase domain 17	Homo sapiens	55-59
30863165-13	2019	Survival in the DEB-TACE group was associated with tumor response, APS grading, and serum bilirubin levels.	Bilirubin	90-99	ADAM metallopeptidase domain 17	Homo sapiens	20-24
30605610-3	2019	As one of antioxidant defense systems, heme oxygenase-1 (HO-1) acts as an essential role in tumor development by offering antioxidant bilirubin to protect cancer cells under stress conditions.	Bilirubin	134-143	heme oxygenase 1	Homo sapiens	57-61
30782273-8	2019	In the PNAC group, the relative mRNA expression of MDR3 in peripheral blood cells was negatively correlated with serum levels of hepatobiliary biochemical parameters (ALT, TBil, DBil, TBA and gamma-GT) (P&lt;0.001).	Bilirubin	172-176	ATP binding cassette subfamily B member 4	Homo sapiens	51-55
30804804-7	2019	The cytoprotective effects of HO-1 depend on several cellular mechanisms including the generation of bilirubin, an anti-oxidant molecule, from the degradation of heme; the induction of ferritin, a strong chelator of free iron; and the release of CO, that displays multiple anti-inflammatory and anti-apoptotic actions.	Bilirubin	101-110	heme oxygenase 1	Homo sapiens	30-34
30784322-6	2019	The percentage of CD5+IL-10+ B cells in CD5+ B lymphocytes in newly diagnosed patients was negatively correlated with haemoglobin (Hb), complement 3 (C3) (p < .05) and positively correlated with lactate dehydrogenase (LDH), total bilirubin (TBIL) and indirect unconjugated bilirubin (IBIL) (p < .05).	Bilirubin	230-239	CD5 molecule	Homo sapiens	18-21
30784322-6	2019	The percentage of CD5+IL-10+ B cells in CD5+ B lymphocytes in newly diagnosed patients was negatively correlated with haemoglobin (Hb), complement 3 (C3) (p < .05) and positively correlated with lactate dehydrogenase (LDH), total bilirubin (TBIL) and indirect unconjugated bilirubin (IBIL) (p < .05).	Bilirubin	230-239	interleukin 10	Homo sapiens	22-27
30784322-6	2019	The percentage of CD5+IL-10+ B cells in CD5+ B lymphocytes in newly diagnosed patients was negatively correlated with haemoglobin (Hb), complement 3 (C3) (p < .05) and positively correlated with lactate dehydrogenase (LDH), total bilirubin (TBIL) and indirect unconjugated bilirubin (IBIL) (p < .05).	Bilirubin	230-239	CD5 molecule	Homo sapiens	40-43
30784322-6	2019	The percentage of CD5+IL-10+ B cells in CD5+ B lymphocytes in newly diagnosed patients was negatively correlated with haemoglobin (Hb), complement 3 (C3) (p < .05) and positively correlated with lactate dehydrogenase (LDH), total bilirubin (TBIL) and indirect unconjugated bilirubin (IBIL) (p < .05).	Bilirubin	241-245	CD5 molecule	Homo sapiens	18-21
30784322-6	2019	The percentage of CD5+IL-10+ B cells in CD5+ B lymphocytes in newly diagnosed patients was negatively correlated with haemoglobin (Hb), complement 3 (C3) (p < .05) and positively correlated with lactate dehydrogenase (LDH), total bilirubin (TBIL) and indirect unconjugated bilirubin (IBIL) (p < .05).	Bilirubin	241-245	interleukin 10	Homo sapiens	22-27
30784322-6	2019	The percentage of CD5+IL-10+ B cells in CD5+ B lymphocytes in newly diagnosed patients was negatively correlated with haemoglobin (Hb), complement 3 (C3) (p < .05) and positively correlated with lactate dehydrogenase (LDH), total bilirubin (TBIL) and indirect unconjugated bilirubin (IBIL) (p < .05).	Bilirubin	241-245	CD5 molecule	Homo sapiens	40-43
30784322-6	2019	The percentage of CD5+IL-10+ B cells in CD5+ B lymphocytes in newly diagnosed patients was negatively correlated with haemoglobin (Hb), complement 3 (C3) (p < .05) and positively correlated with lactate dehydrogenase (LDH), total bilirubin (TBIL) and indirect unconjugated bilirubin (IBIL) (p < .05).	Bilirubin	273-282	CD5 molecule	Homo sapiens	18-21
30784322-6	2019	The percentage of CD5+IL-10+ B cells in CD5+ B lymphocytes in newly diagnosed patients was negatively correlated with haemoglobin (Hb), complement 3 (C3) (p < .05) and positively correlated with lactate dehydrogenase (LDH), total bilirubin (TBIL) and indirect unconjugated bilirubin (IBIL) (p < .05).	Bilirubin	273-282	interleukin 10	Homo sapiens	22-27
30784322-6	2019	The percentage of CD5+IL-10+ B cells in CD5+ B lymphocytes in newly diagnosed patients was negatively correlated with haemoglobin (Hb), complement 3 (C3) (p < .05) and positively correlated with lactate dehydrogenase (LDH), total bilirubin (TBIL) and indirect unconjugated bilirubin (IBIL) (p < .05).	Bilirubin	273-282	CD5 molecule	Homo sapiens	40-43
30891115-8	2019	Intraperitoneal application of 2,3-dehydrosilybins A and B (the most efficient flavonoids from in vitro studies) to mice (50 mg/kg) led to a significant downregulation of UGT1A1 mRNA expression (46 +- 3% of controls, p &lt; 0.005) in the liver and also to a significant increase of the intracellular bilirubin concentration (0.98 +- 0.03vs.1.21 +- 0.02 nmol/mg, p &lt; 0.05).	Bilirubin	300-309	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	171-177
29611873-8	2019	In addition, plasma IDO was positively correlated with TGF-beta among all patients with HCV infection (r = 0.4509, P < 0.0001), with IL-10 in CHC patients (r = 0.4787, P = 0.0047), with TBil in HCV-Cirr patients (r = 0.4671; P = 0.0093).	Bilirubin	186-190	indoleamine 2,3-dioxygenase 1	Homo sapiens	20-23
31054979-2	2019	To examine this hypothesis, we investigated the relationship between plasma bilirubin concentrations and bilirubin UDP-glucuronosyl transferase (UGT1A1) promoter gene variations (associated with increased bilirubin concentrations) with total/CVD and cancer mortality.	Bilirubin	76-85	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	145-151
30657454-5	2019	Bilirubin binds and activates two MRGPRs, mouse MRGPRA1 and human MRGPRX4.	Bilirubin	0-9	MAS-related GPR, member A1	Mus musculus	48-55
30657454-5	2019	Bilirubin binds and activates two MRGPRs, mouse MRGPRA1 and human MRGPRX4.	Bilirubin	0-9	MAS related GPR family member X4	Homo sapiens	66-73
30538149-2	2019	Here, we aimed to ascertain, in the whole rat, whether a similar cholestatic OS injury can be counteracted by heme oxygenase-1 (HO-1) induction that consequently elevates endogenous BR levels.	Bilirubin	182-184	heme oxygenase 1	Rattus norvegicus	110-126
30538149-2	2019	Here, we aimed to ascertain, in the whole rat, whether a similar cholestatic OS injury can be counteracted by heme oxygenase-1 (HO-1) induction that consequently elevates endogenous BR levels.	Bilirubin	182-184	heme oxygenase 1	Rattus norvegicus	128-132
31113585-6	2019	RESULTS: Serum NGAL, but not CysC, was found to significantly correlate with the total bilirubin, international normalized ratio, and model for end-stage liver disease (MELD).	Bilirubin	87-96	lipocalin 2	Homo sapiens	15-19
31054979-2	2019	To examine this hypothesis, we investigated the relationship between plasma bilirubin concentrations and bilirubin UDP-glucuronosyl transferase (UGT1A1) promoter gene variations (associated with increased bilirubin concentrations) with total/CVD and cancer mortality.	Bilirubin	105-114	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	145-151
31054979-2	2019	To examine this hypothesis, we investigated the relationship between plasma bilirubin concentrations and bilirubin UDP-glucuronosyl transferase (UGT1A1) promoter gene variations (associated with increased bilirubin concentrations) with total/CVD and cancer mortality.	Bilirubin	105-114	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	145-151
31054979-10	2019	The UGT1A1*28 allele, a genetic marker of raised bilirubin, was also negatively associated with total/cancer mortality, although the associations were not statistically significant.	Bilirubin	49-58	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	4-10
30392846-6	2019	IL-18 levels correlated positively with bilirubin, INR, ALT and AST levels, and negatively with albumin levels and erythrocyte count.	Bilirubin	40-49	interleukin 18	Homo sapiens	0-5
30508524-7	2019	On the other hand, numerous anti-inflammatory AHR agonists have been identified including bilirubin and quercetin.	Bilirubin	90-99	aryl hydrocarbon receptor	Homo sapiens	46-49
30376387-2	2019	We aimed to evaluate the association between serum total bilirubin level and carotid intima-media thick-ness (cIMT) in patients with prehypertension.	Bilirubin	57-66	CIMT	Homo sapiens	110-114
30376387-5	2019	The correlation between serum total bilirubin and cIMT was assessed by using the Pearson"s correlation coefficient.	Bilirubin	36-45	CIMT	Homo sapiens	50-54
30376387-9	2019	We found that cIMT was significantly related with systolic blood pressure(r = 0.257, P &lt; 0.001), C-reactive protein (r = 0.327, P &lt; 0.001), total cholesterol (r = 0.218, P = 0.002) and total bilirubin (r =-0.489, P &lt; 0.001).	Bilirubin	197-206	CIMT	Homo sapiens	14-18
30376387-11	2019	CONCLUSION: Our results suggested that serum total bilirubin was inversely related with cIMT, and might be an early clinical marker for predicting the occurrence of subclinical carotid atherosclerosis in patients with prehypertension.	Bilirubin	51-60	CIMT	Homo sapiens	88-92
30392846-7	2019	TGF-beta1 levels correlated positively with platelet count, leukocyte, and erythrocyte count, and negatively with bilirubin levels and prothrombin time.	Bilirubin	114-123	transforming growth factor beta 1	Homo sapiens	0-9
30385458-4	2019	CN-1 is an autosomal recessive disorder caused by damaging mutations in the gene for UGT1A1, the hepatic enzyme responsible for bilirubin conjugation in humans.	Bilirubin	128-137	5'-nucleotidase, cytosolic IA	Homo sapiens	0-4
30977446-1	2019	BACKGROUND: Bilirubin has been recognized as a potential endogenous inhibitor of atherosclerosis, being inversely associated with carotid intima-media thickness (CIMT).	Bilirubin	12-21	CIMT	Homo sapiens	162-166
31319653-7	2019	RESULTS: Among the 5 instrumental variables that showed significant associations with serum bilirubin levels, rs12993249 (USP40) showed the most significant association (p&lt;2.36x10-105).	Bilirubin	92-101	ubiquitin specific peptidase 40	Homo sapiens	122-127
30385458-4	2019	CN-1 is an autosomal recessive disorder caused by damaging mutations in the gene for UGT1A1, the hepatic enzyme responsible for bilirubin conjugation in humans.	Bilirubin	128-137	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	85-91
30673679-5	2019	It significantly inhibited CCl4-induced changes of alanine aminotransferase and aspartate aminotransferase activities in serum, as well as nitric oxide synthase (NOS) and cytochrome P450 2E1 (CYP2E1) activities in liver tissue; it also remarkably decreased levels of liver weight and index, total bilirubin, interleukin (IL)-1beta, IL-18, IL-6 and tumor necrosis factor-alpha in serum, as well as malondialdehyde and IL-1beta in liver tissue.	Bilirubin	297-306	chemokine (C-C motif) ligand 4	Mus musculus	27-31
30311140-7	2019	Patients with CN1 were receiving an average 8-15 h of phototherapy per day before APOLT and had normal bilirubin levels without phototherapy on follow-up.	Bilirubin	103-112	5'-nucleotidase, cytosolic IA	Homo sapiens	14-17
30673658-9	2019	Bilirubin induced the active caspase 3 and phosphorylation of p38 in HK-2 cells.	Bilirubin	0-9	caspase 3	Rattus norvegicus	29-38
30673658-9	2019	Bilirubin induced the active caspase 3 and phosphorylation of p38 in HK-2 cells.	Bilirubin	0-9	mitogen activated protein kinase 14	Rattus norvegicus	62-65
30839396-0	2019	Albumin-bilirubin grade may determine the outcomes of patients with very early stage hepatocellular carcinoma after radiofrequency ablation therapy.	Bilirubin	8-17	albumin	Homo sapiens	0-7
30147020-7	2019	The circulating miR-26a and miR-21 levels in patients were positively correlated with serum albumin concentration but negatively correlated with serum total bilirubin concentration and prothrombin time.	Bilirubin	157-166	microRNA 26a-1	Homo sapiens	16-23
30147020-7	2019	The circulating miR-26a and miR-21 levels in patients were positively correlated with serum albumin concentration but negatively correlated with serum total bilirubin concentration and prothrombin time.	Bilirubin	157-166	microRNA 21	Homo sapiens	28-34
30673679-5	2019	It significantly inhibited CCl4-induced changes of alanine aminotransferase and aspartate aminotransferase activities in serum, as well as nitric oxide synthase (NOS) and cytochrome P450 2E1 (CYP2E1) activities in liver tissue; it also remarkably decreased levels of liver weight and index, total bilirubin, interleukin (IL)-1beta, IL-18, IL-6 and tumor necrosis factor-alpha in serum, as well as malondialdehyde and IL-1beta in liver tissue.	Bilirubin	297-306	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	192-198
30009872-4	2019	By converting pro-oxidant heme to the antioxidants, biliverdin and bilirubin, HO-1/biliverdin reductase may help restore a more favorable tissue redox microenvironment.	Bilirubin	67-76	heme oxygenase 1	Homo sapiens	78-82
31055548-9	2019	CONCLUSION: Conclusions: The dysfunction of hepatopancreatobiliary system is more significant in the TT-genotype carriers of IL-4 gene by the AST, ALT, bilirubin and its fractions high levels, however, were found to be risk factors the high levels of total bilirubin and its direct fraction.	Bilirubin	152-161	interleukin 4	Homo sapiens	125-129
31559718-15	2019	SAA levels on days 7 and 14 showed a significant correlation with conjugated bilirubin levels.	Bilirubin	77-86	serum amyloid A1 cluster	Homo sapiens	0-3
31055548-9	2019	CONCLUSION: Conclusions: The dysfunction of hepatopancreatobiliary system is more significant in the TT-genotype carriers of IL-4 gene by the AST, ALT, bilirubin and its fractions high levels, however, were found to be risk factors the high levels of total bilirubin and its direct fraction.	Bilirubin	257-266	interleukin 4	Homo sapiens	125-129
30583467-1	2018	Heme oxygenase (HO)-1 is known to metabolize heme into biliverdin/bilirubin, carbon monoxide, and ferrous iron, and it has been suggested to demonstrate cytoprotective effects against various stress-related conditions.	Bilirubin	66-75	heme oxygenase 1	Homo sapiens	0-21
29959885-0	2018	A peculiar reaction curve with dual spikes in absorbance during a total bilirubin assay in spite of accurate results induced by high M-protein concentration.	Bilirubin	72-81	myomesin 2	Homo sapiens	133-142
30643530-6	2018	CCl4-treated rats that were given 250 or 500 mg/kg of the methanol extract of E. Japonica leaves, or its ethyl acetate, butanol, or aqueous fractions, had significantly lower levels of biochemical parameters such as alanine aminotransferase, aspartate transaminase, alkaline phosphate, total protein, gamma-glutamyl transferase, and bilirubin levels than those of the CCl4 positive group.	Bilirubin	333-342	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
30619479-9	2018	The variants of UGT1A1 *28 and UGT1A1 *6 were strongly associated with increased total bilirubin (TB), direct bilirubin (DB), and indirect bilirubin (IB) levels (each P &lt; 0.001).	Bilirubin	87-96	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	16-22
30619479-9	2018	The variants of UGT1A1 *28 and UGT1A1 *6 were strongly associated with increased total bilirubin (TB), direct bilirubin (DB), and indirect bilirubin (IB) levels (each P &lt; 0.001).	Bilirubin	87-96	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	31-37
30619479-9	2018	The variants of UGT1A1 *28 and UGT1A1 *6 were strongly associated with increased total bilirubin (TB), direct bilirubin (DB), and indirect bilirubin (IB) levels (each P &lt; 0.001).	Bilirubin	98-100	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	16-22
30619479-9	2018	The variants of UGT1A1 *28 and UGT1A1 *6 were strongly associated with increased total bilirubin (TB), direct bilirubin (DB), and indirect bilirubin (IB) levels (each P &lt; 0.001).	Bilirubin	98-100	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	31-37
30619479-9	2018	The variants of UGT1A1 *28 and UGT1A1 *6 were strongly associated with increased total bilirubin (TB), direct bilirubin (DB), and indirect bilirubin (IB) levels (each P &lt; 0.001).	Bilirubin	110-119	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	16-22
30619479-9	2018	The variants of UGT1A1 *28 and UGT1A1 *6 were strongly associated with increased total bilirubin (TB), direct bilirubin (DB), and indirect bilirubin (IB) levels (each P &lt; 0.001).	Bilirubin	110-119	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	31-37
30619479-9	2018	The variants of UGT1A1 *28 and UGT1A1 *6 were strongly associated with increased total bilirubin (TB), direct bilirubin (DB), and indirect bilirubin (IB) levels (each P &lt; 0.001).	Bilirubin	110-119	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	16-22
30619479-9	2018	The variants of UGT1A1 *28 and UGT1A1 *6 were strongly associated with increased total bilirubin (TB), direct bilirubin (DB), and indirect bilirubin (IB) levels (each P &lt; 0.001).	Bilirubin	110-119	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	31-37
30637206-11	2018	Direct Bb was negatively correlated with CRP (P = 0.002).	Bilirubin	7-9	C-reactive protein	Homo sapiens	41-44
30538216-6	2018	After treatment for 4 weeks, the HGF-BM-MSC, BM-MSC and HGF groups exhibited increased protein and mRNA levels of hepatocyte nuclear factor 4alpha, albumin and cytokeratin 18, but decreased levels of aspartate aminotransferase, alanine aminotransferase and total bilirubin.	Bilirubin	263-272	hepatocyte growth factor	Rattus norvegicus	33-36
30538216-6	2018	After treatment for 4 weeks, the HGF-BM-MSC, BM-MSC and HGF groups exhibited increased protein and mRNA levels of hepatocyte nuclear factor 4alpha, albumin and cytokeratin 18, but decreased levels of aspartate aminotransferase, alanine aminotransferase and total bilirubin.	Bilirubin	263-272	hepatocyte growth factor	Rattus norvegicus	56-59
31949688-5	2018	NFkappaB is a key molecule in the downstream signaling pathway of IL-1beta, and the expression of IL-1beta and NFkappaB is positively associated with serum total bilirubin (TBIL).	Bilirubin	162-171	nuclear factor kappa B subunit 1	Homo sapiens	0-8
30280963-1	2018	Gunn rats bear a mutation within the uridine diphosphate glucuronosyltransferase-1a1 (Ugt1a1) gene resulting in high serum bilirubin levels as seen in Crigler-Najjar syndrome.	Bilirubin	123-132	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	37-84
30280963-1	2018	Gunn rats bear a mutation within the uridine diphosphate glucuronosyltransferase-1a1 (Ugt1a1) gene resulting in high serum bilirubin levels as seen in Crigler-Najjar syndrome.	Bilirubin	123-132	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	86-92
30563996-1	2018	Background/objectives: Individuals with Gilbert"s syndrome (GS) harbor mutations in the UGT1A1 gene and are known to have elevated levels of bilirubin, which enhances the risk for gall stone formation.	Bilirubin	141-150	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	88-94
30171692-0	2018	CYP3A4-mediated effects of rifampicin on the pharmacokinetics of vilaprisan and its UGT1A1-mediated effects on bilirubin glucuronidation in humans.	Bilirubin	111-120	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6
30171692-0	2018	CYP3A4-mediated effects of rifampicin on the pharmacokinetics of vilaprisan and its UGT1A1-mediated effects on bilirubin glucuronidation in humans.	Bilirubin	111-120	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	84-90
30171692-2	2018	In addition, the effects of rifampicin on the glucuronidation of bilirubin, an endogenous UDP-glucuronosyltransferase family 1 member A1 (UGT1A1) substrate, were explored.	Bilirubin	65-74	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	90-136
30171692-2	2018	In addition, the effects of rifampicin on the glucuronidation of bilirubin, an endogenous UDP-glucuronosyltransferase family 1 member A1 (UGT1A1) substrate, were explored.	Bilirubin	65-74	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	138-144
30171692-10	2018	Further, it was associated with an increase in bilirubin glucuronidation, indicating that UGT1A1 was induced.	Bilirubin	47-56	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	90-96
31949688-5	2018	NFkappaB is a key molecule in the downstream signaling pathway of IL-1beta, and the expression of IL-1beta and NFkappaB is positively associated with serum total bilirubin (TBIL).	Bilirubin	162-171	interleukin 1 beta	Homo sapiens	98-106
31949688-5	2018	NFkappaB is a key molecule in the downstream signaling pathway of IL-1beta, and the expression of IL-1beta and NFkappaB is positively associated with serum total bilirubin (TBIL).	Bilirubin	162-171	nuclear factor kappa B subunit 1	Homo sapiens	111-119
30333233-9	2018	Critically, the HO-1 products carbon monoxide and bilirubin suppressed the NLRP3-RXR axis in pAECs.	Bilirubin	50-59	heme oxygenase 1	Mus musculus	16-20
30105552-6	2018	This study demonstrates that different variations present in the UGT1A1 gene and specifically, the H55R variation had a significant effect on bilirubin levels and could be genetic risk factors for hyperbilirubinemia.	Bilirubin	142-151	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	65-71
30333233-9	2018	Critically, the HO-1 products carbon monoxide and bilirubin suppressed the NLRP3-RXR axis in pAECs.	Bilirubin	50-59	NLR family, pyrin domain containing 3	Mus musculus	75-80
30620000-9	2019	In Gunn rats transplanted with YAP-Hc+tamoxifen, there was a 65%-81% decline in serum bilirubin over 6 months versus 8%-20% with control-Hc, representing a 3-4-fold increase in therapeutic response.	Bilirubin	86-95	Yes1 associated transcriptional regulator	Rattus norvegicus	31-34
30598724-5	2018	We studied the mechanisms associated with potential toxic action of bilirubin on DNA in in vitro models, which showed significant increases in DNA damage when neuronal and nonneuronal cells were treated with 140 nM of free bilirubin (Bf), as determined by gammaH2AX Western blot and immunofluorescence analyses.	Bilirubin	68-77	H2A.X variant histone	Mus musculus	256-265
30409185-7	2018	RESULTS: We demonstrated that a high concentration of unconjugated bilirubin induced cell death in SHED via the mitochondrial pathway, and this was associated with the suppression of AKT and extracellular signal-related kinase 1 and 2 (ERK1/2) signal pathways and activation of the nuclear factor kappa B (NF-kappaB) signal pathway.	Bilirubin	67-76	AKT serine/threonine kinase 1	Homo sapiens	183-186
30409185-7	2018	RESULTS: We demonstrated that a high concentration of unconjugated bilirubin induced cell death in SHED via the mitochondrial pathway, and this was associated with the suppression of AKT and extracellular signal-related kinase 1 and 2 (ERK1/2) signal pathways and activation of the nuclear factor kappa B (NF-kappaB) signal pathway.	Bilirubin	67-76	mitogen-activated protein kinase 3	Homo sapiens	191-234
30409185-7	2018	RESULTS: We demonstrated that a high concentration of unconjugated bilirubin induced cell death in SHED via the mitochondrial pathway, and this was associated with the suppression of AKT and extracellular signal-related kinase 1 and 2 (ERK1/2) signal pathways and activation of the nuclear factor kappa B (NF-kappaB) signal pathway.	Bilirubin	67-76	mitogen-activated protein kinase 3	Homo sapiens	236-242
30409185-7	2018	RESULTS: We demonstrated that a high concentration of unconjugated bilirubin induced cell death in SHED via the mitochondrial pathway, and this was associated with the suppression of AKT and extracellular signal-related kinase 1 and 2 (ERK1/2) signal pathways and activation of the nuclear factor kappa B (NF-kappaB) signal pathway.	Bilirubin	67-76	nuclear factor kappa B subunit 1	Homo sapiens	282-304
30409185-7	2018	RESULTS: We demonstrated that a high concentration of unconjugated bilirubin induced cell death in SHED via the mitochondrial pathway, and this was associated with the suppression of AKT and extracellular signal-related kinase 1 and 2 (ERK1/2) signal pathways and activation of the nuclear factor kappa B (NF-kappaB) signal pathway.	Bilirubin	67-76	nuclear factor kappa B subunit 1	Homo sapiens	306-315
30409185-9	2018	We then demonstrated that pamidronate decreased the bilirubin-induced cell death in SHED via the altered AKT, ERK1/2, and NF-kappaB signal pathways and recovered the bilirubin-impaired dentinogenic function of SHED.	Bilirubin	52-61	AKT serine/threonine kinase 1	Homo sapiens	105-108
30409185-9	2018	We then demonstrated that pamidronate decreased the bilirubin-induced cell death in SHED via the altered AKT, ERK1/2, and NF-kappaB signal pathways and recovered the bilirubin-impaired dentinogenic function of SHED.	Bilirubin	52-61	mitogen-activated protein kinase 3	Homo sapiens	110-116
30409185-9	2018	We then demonstrated that pamidronate decreased the bilirubin-induced cell death in SHED via the altered AKT, ERK1/2, and NF-kappaB signal pathways and recovered the bilirubin-impaired dentinogenic function of SHED.	Bilirubin	52-61	nuclear factor kappa B subunit 1	Homo sapiens	122-131
30093417-1	2018	Neonatal hyperbilirubinemia and the onset of bilirubin encephalopathy and kernicterus result in part from delayed expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) and the ability to metabolize bilirubin.	Bilirubin	14-23	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	128-159
30610046-3	2018	METHODS: This study was designed to evaluate the relationship between total bilirubin and carotid intima-media thickness (cIMT), a marker of subclinical atherosclerosis, in patients with prehypertension.	Bilirubin	76-85	CIMT	Homo sapiens	122-126
30610046-6	2018	We found that the increased cIMT group has higher systolic blood pressure, triglyceride and C- reactive protein, but lower total bilirubin compared to the normal cIMT group.	Bilirubin	129-138	CIMT	Homo sapiens	28-32
30610046-7	2018	The cIMT was negatively correlated with total bilirubin.	Bilirubin	46-55	CIMT	Homo sapiens	4-8
30610046-9	2018	CONCLUSION: This study demonstrated that serum total bilirubin was inversely related with cIMT, and was an independent predictor of subclinical atherosclerosis in patients with prehypertension.	Bilirubin	53-62	CIMT	Homo sapiens	90-94
30257378-6	2018	In serum the level of hepatic markers; aspartate transaminase, alanine transaminase, alkaline phosphatase and total bilirubin increased with CCl4 treatment against control animals.	Bilirubin	116-125	C-C motif chemokine ligand 4	Rattus norvegicus	141-145
30093417-1	2018	Neonatal hyperbilirubinemia and the onset of bilirubin encephalopathy and kernicterus result in part from delayed expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) and the ability to metabolize bilirubin.	Bilirubin	14-23	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	161-167
30093417-1	2018	Neonatal hyperbilirubinemia and the onset of bilirubin encephalopathy and kernicterus result in part from delayed expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) and the ability to metabolize bilirubin.	Bilirubin	45-54	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	128-159
30093417-1	2018	Neonatal hyperbilirubinemia and the onset of bilirubin encephalopathy and kernicterus result in part from delayed expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) and the ability to metabolize bilirubin.	Bilirubin	45-54	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	161-167
30093417-2	2018	It is generally believed that acute neonatal forms of hyperbilirubinemia develop due to an inability of hepatic UGT1A1 to metabolize efficiently bilirubin for clearance through the hepatobiliary tract.	Bilirubin	59-68	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	112-118
30236988-7	2018	Plasma IL-18 levels were significantly positively associated with Child-Pugh classification, IL-1beta levels, diastolic blood pressure, aspartate aminotransferase, total bilirubin, direct bilirubin, activated partial thromboplastin timealk and aline phosphatase.	Bilirubin	170-179	interleukin 18	Homo sapiens	7-12
30402153-9	2018	Compared with the D-gal group, the contents of AST, ALT, TBiL, AGEs and MDA significantly decreased in the D-gal + Rg1 group, while the activities of SOD and GSH-Px markedly increased, and liver injury and degenerative alterations of hepatocytes were reduced.	Bilirubin	57-61	protein phosphatase 1, regulatory subunit 3A	Mus musculus	115-118
30425912-1	2018	The UGT1A1 enzyme is involved in the metabolism of bilirubin and numerous medications.	Bilirubin	51-60	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	4-10
30425912-11	2018	Level of bilirubin in pediatric GS patients at diagnosis was UGT1A1 (TA)n promoter genotype-dependent.	Bilirubin	9-18	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	61-67
30105461-2	2018	Therefore, it would be beneficial to understand whether there is a relationship between inhibition of uridine-5"-diphosphate glucuronosyltransferase (UGT) 1A1 activity and observed bilirubin elevations in TKI drug-treated patients.	Bilirubin	181-190	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	102-158
30105461-3	2018	UGT1A1 is responsible for the glucuronidation of bilirubin which leads to its elimination in the bile.	Bilirubin	49-58	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
30236988-7	2018	Plasma IL-18 levels were significantly positively associated with Child-Pugh classification, IL-1beta levels, diastolic blood pressure, aspartate aminotransferase, total bilirubin, direct bilirubin, activated partial thromboplastin timealk and aline phosphatase.	Bilirubin	188-197	interleukin 18	Homo sapiens	7-12
30266131-1	2018	Crigler-Najjar syndrome type II is caused by mutations in the UGT1A1 gene resulting in severely reduced hepatic activity of UDP-glucoronyltransferase - an enzyme required to convert bilirubin into a more soluble form that can then be removed from the body.	Bilirubin	182-191	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	62-68
30098497-5	2018	Our results indicated that treatment with OCT markedly down-regulated the protein and mRNA expression of liver fibrosis markers including alpha-smooth muscle actin (alpha-SMA) and collagen I in CCl4-induced rat model of liver fibrosis, accompanied by decreasing aspartate transaminase (AST), alanine transaminase (ALT), total bilirubin (TBIL) activities and increasing the serum level of albumin (ALB).	Bilirubin	326-335	plexin A2	Homo sapiens	42-45
30098497-5	2018	Our results indicated that treatment with OCT markedly down-regulated the protein and mRNA expression of liver fibrosis markers including alpha-smooth muscle actin (alpha-SMA) and collagen I in CCl4-induced rat model of liver fibrosis, accompanied by decreasing aspartate transaminase (AST), alanine transaminase (ALT), total bilirubin (TBIL) activities and increasing the serum level of albumin (ALB).	Bilirubin	337-341	plexin A2	Homo sapiens	42-45
29974998-6	2018	Moreover, the expression of HO-1, a functional modulator of Tregs, was decreased in vitiligo Tregs, and the concentrations of HO-1 metabolites, including bilirubin, CoHb and iron, were correspondingly decreased in serum of vitiligo patients.	Bilirubin	154-163	heme oxygenase 1	Homo sapiens	126-130
30205766-9	2018	Increases in liver enzymes and bilirubin were more pronounced in response to AA or 4,4"-MDA than to CCl4 at early time points.	Bilirubin	31-40	C-C motif chemokine ligand 4	Rattus norvegicus	100-104
30295264-6	2018	All of 43 patients showed decreased G6PD activity,while the level of their indirect serum bilirubin(IBIL)was positively correlated with reticulocyte percentage(Ret%,r=0.5881,P=0.013) and mean corpuscular volume(MCV,r=0.6854,P=0.0024).	Bilirubin	90-99	ret proto-oncogene	Homo sapiens	160-163
29954046-7	2018	Cystatin C and cystatin C-based equations are less influenced by muscle mass or bilirubin value, but their dosage is not standardized and they are expensive.	Bilirubin	80-89	cystatin C	Homo sapiens	0-10
29954046-7	2018	Cystatin C and cystatin C-based equations are less influenced by muscle mass or bilirubin value, but their dosage is not standardized and they are expensive.	Bilirubin	80-89	cystatin C	Homo sapiens	15-25
29309376-8	2018	In addition, we analyzed bilirubin uridine diphosphate (UDP)-glucuronosyltransferase 1A1 gene that revealed a heterozygous state ([TA]6/[TA]7).	Bilirubin	25-34	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	35-88
29967530-5	2018	These parameters can be established using a plasma bilirubin binding panel (BBP) consisting of BT, Bf, and two empiric constants, the maximum BT (BTmax) and the corresponding equilibrium association bilirubin constant (K).	Bilirubin	51-60	transmembrane protein 158	Homo sapiens	76-79
29967530-7	2018	Once Bf population parameters are known, the BBP in a newborn can be used to identify poor bilirubin binding (higher Bf at the threshold BT compared with the population) and increased risk of BIND.	Bilirubin	91-100	transmembrane protein 158	Homo sapiens	45-48
30157576-8	2018	Conclusions: Higher level of preoperative TBIL(&gt;21 mumol/L) and ALT(&gt;50 U/L) and the larger amount of intraoperative bleeding (more than 400 ml) are independent risk factors for failure of ERAS inpatients undergoing hepatectomy for HCC and the established prediction model may have certain value for risk assessment.	Bilirubin	42-46	ES cell expressed Ras	Homo sapiens	195-199
30249938-11	2018	Moreover, the effect of low serum albumin on the risk of MCI was further enhanced among the subjects with hypertension, diabetes, hyperlipemia, cardiovascular disease, cerebrovascular disease, high serum levels of C-reactive protein, or relatively low levels of uric acid or total bilirubin.	Bilirubin	281-290	albumin	Homo sapiens	34-41
30123925-6	2018	CCl4 caused marked liver damage as evident by significant increased activities of serum alkaline phosphatase, bilirubin, lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, Interleukin 10 and Tumor necrosis factor-alpha levels compared to normal control.	Bilirubin	110-119	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
30153269-4	2018	Experiments with pharmacological inhibitors and target-specific siRNAs revealed that HIF-1alpha levels were highly correlated with increased PGC-1alpha and ERRalpha levels, which were linked to the HO metabolites CO- and bilirubin-induced activation of apical L-type Ca2+ channel and sequential Ca2+-dependent signal transduction.	Bilirubin	221-230	hypoxia inducible factor 1 subunit alpha	Homo sapiens	85-95
30153269-4	2018	Experiments with pharmacological inhibitors and target-specific siRNAs revealed that HIF-1alpha levels were highly correlated with increased PGC-1alpha and ERRalpha levels, which were linked to the HO metabolites CO- and bilirubin-induced activation of apical L-type Ca2+ channel and sequential Ca2+-dependent signal transduction.	Bilirubin	221-230	PPARG coactivator 1 alpha	Homo sapiens	141-151
30153269-4	2018	Experiments with pharmacological inhibitors and target-specific siRNAs revealed that HIF-1alpha levels were highly correlated with increased PGC-1alpha and ERRalpha levels, which were linked to the HO metabolites CO- and bilirubin-induced activation of apical L-type Ca2+ channel and sequential Ca2+-dependent signal transduction.	Bilirubin	221-230	estrogen related receptor alpha	Homo sapiens	156-164
30153269-7	2018	These data suggest that the HO-1-derived metabolites, CO and bilirubin, elevate astrocytic mitochondrial function via a HIF-1alpha/ERRalpha circuit coupled with L-type Ca2+ channel activation and PGC-1alpha-mediated oxygen consumption.	Bilirubin	61-70	heme oxygenase 1	Homo sapiens	28-32
29898414-8	2018	Furthermore, the binding of biotin-tagged BR to Kelch-like ECH-associated protein 1 (KEAP1)-a biological electrophile sensor-was prevented by pretreatment with BR or a thiol compound, but was not by pretreatment with BV.	Bilirubin	42-44	kelch like ECH associated protein 1	Homo sapiens	48-83
29754000-7	2018	RESULTS: The changes in majority of PFAS concentrations were positively associated with the changes in activity of ALT, ALP, and GGT and inversely associated with the changes in circulating bilirubin after adjustment for gender and the time-updated covariates LDL- and HDL-cholesterol, serum triglycerides, BMI, statin use, smoking, fasting glucose levels and correction for multiple testing.	Bilirubin	190-199	phosphoribosylformylglycinamidine synthase	Homo sapiens	36-40
29898414-8	2018	Furthermore, the binding of biotin-tagged BR to Kelch-like ECH-associated protein 1 (KEAP1)-a biological electrophile sensor-was prevented by pretreatment with BR or a thiol compound, but was not by pretreatment with BV.	Bilirubin	42-44	kelch like ECH associated protein 1	Homo sapiens	85-90
29898414-9	2018	In cells, BR could bind to KEAP1 to release and activate nuclear factor-erythroid 2 (NF-E2) p45-related factor 2, a cytoprotective transcription factor, leading to the induction of HO-1.	Bilirubin	10-12	kelch like ECH associated protein 1	Homo sapiens	27-32
29898414-9	2018	In cells, BR could bind to KEAP1 to release and activate nuclear factor-erythroid 2 (NF-E2) p45-related factor 2, a cytoprotective transcription factor, leading to the induction of HO-1.	Bilirubin	10-12	nuclear factor, erythroid 2	Homo sapiens	57-83
29898414-9	2018	In cells, BR could bind to KEAP1 to release and activate nuclear factor-erythroid 2 (NF-E2) p45-related factor 2, a cytoprotective transcription factor, leading to the induction of HO-1.	Bilirubin	10-12	nuclear factor, erythroid 2	Homo sapiens	85-90
30106954-15	2018	This was carried out genetically using lipocalin-2 (LCN2)-null mice, which is an inflammatory cytokine highly upregulated in response to bilirubin.	Bilirubin	137-146	lipocalin 2	Mus musculus	39-50
30106954-15	2018	This was carried out genetically using lipocalin-2 (LCN2)-null mice, which is an inflammatory cytokine highly upregulated in response to bilirubin.	Bilirubin	137-146	lipocalin 2	Mus musculus	52-56
30153269-7	2018	These data suggest that the HO-1-derived metabolites, CO and bilirubin, elevate astrocytic mitochondrial function via a HIF-1alpha/ERRalpha circuit coupled with L-type Ca2+ channel activation and PGC-1alpha-mediated oxygen consumption.	Bilirubin	61-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	120-130
30153269-7	2018	These data suggest that the HO-1-derived metabolites, CO and bilirubin, elevate astrocytic mitochondrial function via a HIF-1alpha/ERRalpha circuit coupled with L-type Ca2+ channel activation and PGC-1alpha-mediated oxygen consumption.	Bilirubin	61-70	estrogen related receptor alpha	Homo sapiens	131-139
30153269-7	2018	These data suggest that the HO-1-derived metabolites, CO and bilirubin, elevate astrocytic mitochondrial function via a HIF-1alpha/ERRalpha circuit coupled with L-type Ca2+ channel activation and PGC-1alpha-mediated oxygen consumption.	Bilirubin	61-70	PPARG coactivator 1 alpha	Homo sapiens	196-206
30159062-8	2018	Furthermore, there were significant relationships between different degrees of bilirubin with TSH, T4 levels and G6PD (P &lt; 0.05).	Bilirubin	79-88	glucose-6-phosphate dehydrogenase	Homo sapiens	113-117
29968261-5	2018	RESULTS: Patients with hypoalbuminemia had higher serum levels of liver enzymes (P &lt; 0.05) and total bilirubin (P &lt; 0.001) and significantly lower platelet counts (P = 0.02) and prealbumin levels (P &lt; 0.001) than patients with normal preoperative albumin levels.	Bilirubin	104-113	albumin	Homo sapiens	27-34
29396898-4	2018	RESULTS: Multiple linear regression model analysis revealed that hepatic perfusion-uptake index (HPUI = -K1a  + K1p  + Ki ) (P &lt; 0.0001), albumin-bilirubin linear predictor (ALBI-LP = 0.66 x log10 T-BIL - 0.085 x ALB) (P = 0.034), and blood platelet count (P = 0.046) were significant independent predictors of LS (r = 0.863).	Bilirubin	149-158	albumin	Homo sapiens	141-148
30083087-4	2018	Oral administration of FPLR (100 mg/kg bw) to mice significantly reduced the CCl4-induced elevation of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, triacylglycerols, total cholesterol, and total bilirubin.	Bilirubin	232-241	chemokine (C-C motif) ligand 4	Mus musculus	77-81
30068325-11	2018	Further in vitro studies showed that 1) silica-induced HO-1 was significantly attenuated by inhibiting ERK activation, and 2) carbon monoxide and bilirubin as final byproducts of HO-1 could inhibit ERK activation.	Bilirubin	146-155	heme oxygenase 1	Mus musculus	55-59
30068325-11	2018	Further in vitro studies showed that 1) silica-induced HO-1 was significantly attenuated by inhibiting ERK activation, and 2) carbon monoxide and bilirubin as final byproducts of HO-1 could inhibit ERK activation.	Bilirubin	146-155	heme oxygenase 1	Mus musculus	179-183
30068325-11	2018	Further in vitro studies showed that 1) silica-induced HO-1 was significantly attenuated by inhibiting ERK activation, and 2) carbon monoxide and bilirubin as final byproducts of HO-1 could inhibit ERK activation.	Bilirubin	146-155	mitogen-activated protein kinase 1	Mus musculus	198-201
30068325-12	2018	Taken together, silica-induced HO-1 upregulation was mediated by ERK activation, and HO-1 further regulates ERK activation via its final byproducts, carbon monoxide and bilirubin.	Bilirubin	169-178	heme oxygenase 1	Mus musculus	85-89
30068325-12	2018	Taken together, silica-induced HO-1 upregulation was mediated by ERK activation, and HO-1 further regulates ERK activation via its final byproducts, carbon monoxide and bilirubin.	Bilirubin	169-178	mitogen-activated protein kinase 1	Mus musculus	108-111
30100908-12	2018	Bilirubin and BAs were able to induce hBD-1 in hepatic cell cultures in vitro.	Bilirubin	0-9	defensin beta 1	Homo sapiens	38-43
30100908-15	2018	It is induced during cholestasis through bilirubin and BAs, mediated by CAR and especially FXR.	Bilirubin	41-50	nuclear receptor subfamily 1, group I, member 3	Mus musculus	72-75
30100908-15	2018	It is induced during cholestasis through bilirubin and BAs, mediated by CAR and especially FXR.	Bilirubin	41-50	nuclear receptor subfamily 1, group H, member 4	Mus musculus	91-94
30100908-0	2018	beta-Defensin 1 Is Prominent in the Liver and Induced During Cholestasis by Bilirubin and Bile Acids via Farnesoid X Receptor and Constitutive Androstane Receptor.	Bilirubin	76-85	defensin beta 1	Mus musculus	0-15
30100908-6	2018	Regulation of hBD-1 via bilirubin and bile acids (BAs) was studied using siRNA.	Bilirubin	24-33	defensin beta 1	Homo sapiens	14-19
30028262-5	2018	The modified Fisher scale (mF) grades (beta = 0.407, p = 0.005) and CSF bilirubin concentrations (beta = 0.311, p = 0.015) were positively and independently associated with CSF macrophage CD163 expression when the analysis was controlled for age and sex.	Bilirubin	72-81	CD163 molecule	Homo sapiens	188-193
29316063-6	2018	RESULTS: Bilirubin induced cell death and inhibited the odontogenic capacity of SHED by suppressing AKT and extracellular signal-regulated kinase 1 and 2 (ERK1/2) pathways and enhancing nuclear factor kappa B p65 (NF-kappaB p65) pathway.	Bilirubin	9-18	AKT serine/threonine kinase 1	Homo sapiens	100-103
30344979-8	2018	Our findings revealed that maternal age, weight, BMI, WBC, Hb, PLT, birth in the first pregnancy, numbers of pregnancies and prolonged delivery were significantly associated with bilirubin levels.	Bilirubin	179-188	N-acylethanolamine acid amidase	Homo sapiens	63-66
29448836-2	2018	Crigler-Najjar syndrome is an autosomal recessive disorder of bilirubin metabolism that occurs when the liver"s uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) enzyme activity is partially or completely absent.	Bilirubin	62-71	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	162-168
29448836-6	2018	Newborn UGT1 KO mice treated with AAV had serum total bilirubin levels that were 5.7 times higher than the levels seen in heterozygous and wild-type mice, likely due to dilution of vector genome copies (GC) in the liver resulting from a proliferation of hepatocytes during growth of the animal.	Bilirubin	54-63	UDP glucuronosyltransferase 1 family, polypeptide A2	Mus musculus	8-12
29448836-7	2018	The elevation in serum total bilirubin levels in adult UGT1 KO mice depended on the AAV8 vector dose.	Bilirubin	29-38	UDP glucuronosyltransferase 1 family, polypeptide A2	Mus musculus	55-59
29448836-11	2018	Therefore, a low-level and likely transient decrease in serum total bilirubin during the first days of life is necessary for rescuing the lethal phenotype present in the neonatal UGT1 KO mouse.	Bilirubin	68-77	UDP glucuronosyltransferase 1 family, polypeptide A2	Mus musculus	179-183
29316063-6	2018	RESULTS: Bilirubin induced cell death and inhibited the odontogenic capacity of SHED by suppressing AKT and extracellular signal-regulated kinase 1 and 2 (ERK1/2) pathways and enhancing nuclear factor kappa B p65 (NF-kappaB p65) pathway.	Bilirubin	9-18	mitogen-activated protein kinase 1	Homo sapiens	108-153
29316063-6	2018	RESULTS: Bilirubin induced cell death and inhibited the odontogenic capacity of SHED by suppressing AKT and extracellular signal-regulated kinase 1 and 2 (ERK1/2) pathways and enhancing nuclear factor kappa B p65 (NF-kappaB p65) pathway.	Bilirubin	9-18	mitogen-activated protein kinase 3	Homo sapiens	155-161
29316063-6	2018	RESULTS: Bilirubin induced cell death and inhibited the odontogenic capacity of SHED by suppressing AKT and extracellular signal-regulated kinase 1 and 2 (ERK1/2) pathways and enhancing nuclear factor kappa B p65 (NF-kappaB p65) pathway.	Bilirubin	9-18	RELA proto-oncogene, NF-kB subunit	Homo sapiens	186-212
29316063-6	2018	RESULTS: Bilirubin induced cell death and inhibited the odontogenic capacity of SHED by suppressing AKT and extracellular signal-regulated kinase 1 and 2 (ERK1/2) pathways and enhancing nuclear factor kappa B p65 (NF-kappaB p65) pathway.	Bilirubin	9-18	RELA proto-oncogene, NF-kB subunit	Homo sapiens	214-227
29316063-8	2018	The bilirubin interruption also normalized the impaired AKT, ERK1/2, and NF-kappaB p65 signaling pathways.	Bilirubin	4-13	AKT serine/threonine kinase 1	Homo sapiens	56-59
29316063-8	2018	The bilirubin interruption also normalized the impaired AKT, ERK1/2, and NF-kappaB p65 signaling pathways.	Bilirubin	4-13	mitogen-activated protein kinase 3	Homo sapiens	61-67
29316063-8	2018	The bilirubin interruption also normalized the impaired AKT, ERK1/2, and NF-kappaB p65 signaling pathways.	Bilirubin	4-13	RELA proto-oncogene, NF-kB subunit	Homo sapiens	73-86
29316063-9	2018	CONCLUSION: These findings suggest that tooth hypodontia in patients with hyperbilirubinemia might be due to bilirubin-induced cell death and dentinogenic dysfunction of odontogenic stem cells via AKT, ERK1/2, and NF-kappaB pathways and also suggested that bilirubin-induced impairments in odontogenic stem cells were reversible when bilirubin stimulation is interrupted.	Bilirubin	79-88	AKT serine/threonine kinase 1	Homo sapiens	197-200
29847509-9	2018	As a positive control, baseline plasma bilirubin concentration was associated with predicted liver UGT1A1 expression level (P=1.9x10(-27)).	Bilirubin	39-48	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	99-105
29316063-9	2018	CONCLUSION: These findings suggest that tooth hypodontia in patients with hyperbilirubinemia might be due to bilirubin-induced cell death and dentinogenic dysfunction of odontogenic stem cells via AKT, ERK1/2, and NF-kappaB pathways and also suggested that bilirubin-induced impairments in odontogenic stem cells were reversible when bilirubin stimulation is interrupted.	Bilirubin	109-118	AKT serine/threonine kinase 1	Homo sapiens	197-200
29316063-9	2018	CONCLUSION: These findings suggest that tooth hypodontia in patients with hyperbilirubinemia might be due to bilirubin-induced cell death and dentinogenic dysfunction of odontogenic stem cells via AKT, ERK1/2, and NF-kappaB pathways and also suggested that bilirubin-induced impairments in odontogenic stem cells were reversible when bilirubin stimulation is interrupted.	Bilirubin	109-118	mitogen-activated protein kinase 3	Homo sapiens	202-208
29316063-9	2018	CONCLUSION: These findings suggest that tooth hypodontia in patients with hyperbilirubinemia might be due to bilirubin-induced cell death and dentinogenic dysfunction of odontogenic stem cells via AKT, ERK1/2, and NF-kappaB pathways and also suggested that bilirubin-induced impairments in odontogenic stem cells were reversible when bilirubin stimulation is interrupted.	Bilirubin	109-118	AKT serine/threonine kinase 1	Homo sapiens	197-200
29316063-9	2018	CONCLUSION: These findings suggest that tooth hypodontia in patients with hyperbilirubinemia might be due to bilirubin-induced cell death and dentinogenic dysfunction of odontogenic stem cells via AKT, ERK1/2, and NF-kappaB pathways and also suggested that bilirubin-induced impairments in odontogenic stem cells were reversible when bilirubin stimulation is interrupted.	Bilirubin	109-118	mitogen-activated protein kinase 3	Homo sapiens	202-208
29494209-5	2018	The antioxidant bilirubin and the enzyme that generates it, biliverdin reductase A (BVRA), are components of the heme catabolic pathway that have been shown to reduce hepatic steatosis.	Bilirubin	16-25	biliverdin reductase A	Homo sapiens	84-88
29922067-9	2018	Age, ejection fraction, left atrial size, estimated glomerular filtration rate, and direct and indirect bilirubin levels were significantly correlated to serum B12 level in univariate analysis.	Bilirubin	104-113	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	160-163
29922067-10	2018	In multivariate analysis, independent correlates of B12 were direct bilirubin (R=0.51, P&lt;0.001) and age (R=0.19, P=0.028).	Bilirubin	68-77	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	52-55
29922067-15	2018	Conclusion: Increased B12 in stable HF patients is associated with increased direct bilirubin due to right HF, indicating a cardiohepatic syndrome, but neither B12 nor folic acid are independently associated with mortality.	Bilirubin	84-93	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	22-25
29710522-8	2018	Serum analysis revealed that CCl4 intoxication increased the levels of bilirubin and blood urea nitrogen (BUN).	Bilirubin	71-80	C-C motif chemokine ligand 4	Rattus norvegicus	29-33
29988557-7	2018	Compared with sham-treated animals, mice subjected to Stx2 developed profound weight loss, kidney dysfunction (elevation of plasma urea, creatinine, and neutrophil gelatinase-associated lipocalin), kidney injury (tubular injury and loss of endothelial cells), thrombotic microangiopathy (arteriolar microthrombi), and hemolysis (elevation of plasma bilirubin, lactate dehydrogenase, and free hemoglobin).	Bilirubin	349-358	syntaxin 2	Mus musculus	54-58
29915268-6	2018	Serum chemerin correlated with markers of hepatic function (total bilirubin, albumin, INR) and inversely correlated with indicators of portal hypertension (platelet count, gastrointestinal bleeding) but not with extrahepatic organ failure and systemic inflammation.	Bilirubin	66-75	retinoic acid receptor responder 2	Homo sapiens	6-14
29963243-8	2018	Importantly, ISG20 levels were strongly correlated with the levels of AST, ALT, total and direct bilirubin among HCC patients (Pearson"s r = 0.43, 0.35, 0.34, 0.3; P&lt;0.0001, respectively).	Bilirubin	97-106	interferon stimulated exonuclease gene 20	Homo sapiens	13-18
29604585-8	2018	Correlation analysis showed positive correlation of MALAT1 with total bilirubin (r = 0.456, P &lt;0.001) and AST (r = 0.280, P = 0.019), and negative correlation with the hemoglobin level (r = 0.312, P = 0.009).	Bilirubin	70-79	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	52-58
29637732-2	2018	Delivery of hUGT1A1-modRNA (a modified messenger RNA encoding for UGT1A1) as a lipid nanoparticle is anticipated to restore hepatic expression of UGT1A1, allowing normal glucuronidation and clearance of bilirubin in patients.	Bilirubin	203-212	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	12-19
29637732-2	2018	Delivery of hUGT1A1-modRNA (a modified messenger RNA encoding for UGT1A1) as a lipid nanoparticle is anticipated to restore hepatic expression of UGT1A1, allowing normal glucuronidation and clearance of bilirubin in patients.	Bilirubin	203-212	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	13-19
29637732-2	2018	Delivery of hUGT1A1-modRNA (a modified messenger RNA encoding for UGT1A1) as a lipid nanoparticle is anticipated to restore hepatic expression of UGT1A1, allowing normal glucuronidation and clearance of bilirubin in patients.	Bilirubin	203-212	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	66-72
29718219-8	2018	Loss of this axis in Fxr:Shp:Car:Pxr quadruple knockouts blocked Cyp2b/Cyp2c gene induction, impaired bilirubin conjugation/elimination, and increased liver injury.	Bilirubin	102-111	nuclear receptor subfamily 1 group H member 4	Homo sapiens	21-24
29281894-12	2018	Fibrosis and measures of hepatic injury were significantly reduced in AAV2-miR19b-treated rats in combination with significant improvements in total and direct bilirubin.	Bilirubin	160-169	microRNA 19b-1	Homo sapiens	75-81
29395967-8	2018	RESULTS: Regression analyses revealed that serum albumin levels, total-bilirubin levels, calcium levels, and HOMA-IR were positively correlated with IGF-I levels.	Bilirubin	71-80	insulin like growth factor 1	Homo sapiens	149-154
29395967-11	2018	CONCLUSION: In this study, we demonstrated that serum bilirubin and calcium levels are correlated with serum IGF-I levels.	Bilirubin	54-63	insulin like growth factor 1	Homo sapiens	109-114
29395967-12	2018	Although further study is necessary, these data suggest a presence of interaction between GH-IGF-I axis and bilirubin and calcium metabolism.	Bilirubin	108-117	insulin like growth factor 1	Homo sapiens	93-98
29718219-8	2018	Loss of this axis in Fxr:Shp:Car:Pxr quadruple knockouts blocked Cyp2b/Cyp2c gene induction, impaired bilirubin conjugation/elimination, and increased liver injury.	Bilirubin	102-111	nuclear receptor subfamily 0 group B member 2	Homo sapiens	25-28
29718219-8	2018	Loss of this axis in Fxr:Shp:Car:Pxr quadruple knockouts blocked Cyp2b/Cyp2c gene induction, impaired bilirubin conjugation/elimination, and increased liver injury.	Bilirubin	102-111	nuclear receptor subfamily 1 group I member 3	Homo sapiens	29-32
29718219-8	2018	Loss of this axis in Fxr:Shp:Car:Pxr quadruple knockouts blocked Cyp2b/Cyp2c gene induction, impaired bilirubin conjugation/elimination, and increased liver injury.	Bilirubin	102-111	nuclear receptor subfamily 1 group I member 2	Homo sapiens	33-36
29718219-10	2018	In conclusion, loss of FXR/SHP results in distinct molecular pathogenesis and CAR/PXR activation, which promotes Cyp2b/Cyp2c gene transcription and bilirubin clearance.	Bilirubin	148-157	nuclear receptor subfamily 1 group H member 4	Homo sapiens	23-26
29718219-10	2018	In conclusion, loss of FXR/SHP results in distinct molecular pathogenesis and CAR/PXR activation, which promotes Cyp2b/Cyp2c gene transcription and bilirubin clearance.	Bilirubin	148-157	nuclear receptor subfamily 0 group B member 2	Homo sapiens	27-30
29718219-10	2018	In conclusion, loss of FXR/SHP results in distinct molecular pathogenesis and CAR/PXR activation, which promotes Cyp2b/Cyp2c gene transcription and bilirubin clearance.	Bilirubin	148-157	nuclear receptor subfamily 1 group I member 3	Homo sapiens	78-81
29718219-10	2018	In conclusion, loss of FXR/SHP results in distinct molecular pathogenesis and CAR/PXR activation, which promotes Cyp2b/Cyp2c gene transcription and bilirubin clearance.	Bilirubin	148-157	nuclear receptor subfamily 1 group I member 2	Homo sapiens	82-85
29356312-8	2018	The superior therapeutic effects of combination treatment were also confirmed in Mdr2-/- mice where a significant reduction in plasma liver enzymes, bilirubin, liver fibrosis, bile duct proliferation and hepatic infiltration of neutrophils and T cells and expression of cytokines were found.	Bilirubin	149-158	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	81-85
29488168-5	2018	c-Myb mRNA expression in hemolysis patients was significantly higher than in remission patients and CLL patients, negatively correlated with hemoglobin (Hb) level and complement 3(C3) levels, and positively correlated with total bilirubin (TBIL) concentration and indirect bilirubin (IBIL) concentration.	Bilirubin	229-238	MYB proto-oncogene, transcription factor	Homo sapiens	0-5
29488168-5	2018	c-Myb mRNA expression in hemolysis patients was significantly higher than in remission patients and CLL patients, negatively correlated with hemoglobin (Hb) level and complement 3(C3) levels, and positively correlated with total bilirubin (TBIL) concentration and indirect bilirubin (IBIL) concentration.	Bilirubin	240-244	MYB proto-oncogene, transcription factor	Homo sapiens	0-5
29488168-5	2018	c-Myb mRNA expression in hemolysis patients was significantly higher than in remission patients and CLL patients, negatively correlated with hemoglobin (Hb) level and complement 3(C3) levels, and positively correlated with total bilirubin (TBIL) concentration and indirect bilirubin (IBIL) concentration.	Bilirubin	273-282	MYB proto-oncogene, transcription factor	Homo sapiens	0-5
29488168-7	2018	miR-150 was negatively correlated with TBIL and IBIL, and positively correlated with Hb, C3.	Bilirubin	39-43	microRNA 150	Homo sapiens	0-7
29899711-15	2018	The positive correlation between EPO and bilirubin may be indicative of, for example, the mutual antioxidative effect of these factors.	Bilirubin	41-50	erythropoietin	Homo sapiens	33-36
29899711-10	2018	There was a positive correlation (P &lt; 0.05) between the EPO and IL-3, bilirubin, mean corpuscular hemoglobin, and red blood cell distribution width - standard deviation.	Bilirubin	73-82	erythropoietin	Homo sapiens	59-62
29388792-6	2018	GATA6 expression in BA livers correlates with two established negative prognostic indicators (age at PE, degree of intrahepatic bile ductule expansion) and decreases after normalization of serum bilirubin by PE.	Bilirubin	195-204	GATA binding protein 6	Homo sapiens	0-5
29891453-0	2018	[Role of caspase-1 activation in bilirubin-induced injury in cultured primary rat hippocampal neurons].	Bilirubin	33-42	caspase 1	Rattus norvegicus	9-18
29891453-5	2018	RESULTS: In cultured primary rat hippocampal neurons, bilirubin exposure for 3 and 6 h caused significant increases in the expressions of NLRP3 and activated caspase-1 compared with those in the control group (P&lt;0.05).	Bilirubin	54-63	NLR family, pyrin domain containing 3	Rattus norvegicus	138-143
29891453-5	2018	RESULTS: In cultured primary rat hippocampal neurons, bilirubin exposure for 3 and 6 h caused significant increases in the expressions of NLRP3 and activated caspase-1 compared with those in the control group (P&lt;0.05).	Bilirubin	54-63	caspase 1	Rattus norvegicus	158-167
29891453-6	2018	Pretreatment of the cells with VX-765 obviously suppressed bilirubin-induced activation of caspase-1 (P&lt;0.05).	Bilirubin	59-68	caspase 1	Rattus norvegicus	91-100
29891453-9	2018	CONCLUSION: In cultured primary rat hippocampal neurons, caspase-1 activation plays a role in bilirubin-induced neurotoxicity, and VX-765 treatment provides protection against bilirubin-induced neuronal injury by inhibiting caspase-1 activation.	Bilirubin	94-103	caspase 1	Rattus norvegicus	57-66
29168311-7	2018	Moreover, WFA+ -M2BP showed a significant positive correlation (P &lt; 0.05) with autoimmune hepatitis overlap, AST, alanine aminotransferase (ALT), gamma-glutamyltransferase, total bilirubin, immunoglobulin G, APRI, and hyaluronic acid.	Bilirubin	182-191	galectin 3 binding protein	Homo sapiens	16-20
29481425-8	2018	High secretoneurin levels on day 1 were associated with age and serum concentrations of lactate, bilirubin, creatinine, and N-terminal pro-B-type natriuretic peptide.	Bilirubin	97-106	secretogranin II	Homo sapiens	5-18
29479832-3	2018	In this setting, sclerostin, a key regulator of the Wnt/beta-catenin signalling pathway which regulates bone formation, in addition to the effects of the retained substances of cholestasis such as bilirubin and bile acids on osteoblastic cells, may influence the decreased bone formation in chronic cholestasis.	Bilirubin	197-206	sclerostin	Homo sapiens	17-27
29117728-10	2018	While female gender (OR, 2.11; 95%CI, 1.20-3.73) and normal total bilirubin (OR, 1.93; 95%CI, 1.13-3.32) were related to PEP in CBDS group.	Bilirubin	66-75	progestagen associated endometrial protein	Homo sapiens	121-124
31435333-8	2018	Results: Administration of CCl4 resulted in liver injury with significant elevation in the hepatocellular injury markers alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TBIL), and conjugated bilirubin (CBIL), associated with a significant reduction in total circulatory protein.	Bilirubin	221-230	C-C motif chemokine ligand 4	Rattus norvegicus	27-31
31435333-8	2018	Results: Administration of CCl4 resulted in liver injury with significant elevation in the hepatocellular injury markers alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TBIL), and conjugated bilirubin (CBIL), associated with a significant reduction in total circulatory protein.	Bilirubin	232-236	C-C motif chemokine ligand 4	Rattus norvegicus	27-31
31435333-8	2018	Results: Administration of CCl4 resulted in liver injury with significant elevation in the hepatocellular injury markers alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TBIL), and conjugated bilirubin (CBIL), associated with a significant reduction in total circulatory protein.	Bilirubin	254-263	C-C motif chemokine ligand 4	Rattus norvegicus	27-31
29735787-7	2018	RESULTS: The model is: R = 0.94 x Bilirubin + 0.53 x evolution of Bilirubin - 0.45 x PT-A - 0.22 x evolution in PT-A -0.1 x PLT + 10 x anti-HBe.	Bilirubin	34-43	pre T cell antigen receptor alpha	Homo sapiens	112-116
29447590-0	2018	Correction to: Li, X., Li, W., Shi, Mo, Luo, Qin, Yang and Mo, Is serum bilirubin associated with the severity of Guillain-Barre syndrome?	Bilirubin	72-81	forkhead box G1	Homo sapiens	45-48
29099687-0	2018	Conjugated Bilirubin Upregulates TIM-3 Expression on CD4+CD25+ T Cells: Anti-Inflammatory Implications for Hepatitis A Virus Infection.	Bilirubin	11-20	hepatitis A virus cellular receptor 2	Homo sapiens	33-38
29302043-3	2018	Heme oxygenase-1 (HO) is the rate limiting enzyme in heme metabolism leading to the equimolar production of bilirubin, carbon monoxide (CO) and free iron (Fe).	Bilirubin	108-117	heme oxygenase 1	Homo sapiens	0-16
29099687-0	2018	Conjugated Bilirubin Upregulates TIM-3 Expression on CD4+CD25+ T Cells: Anti-Inflammatory Implications for Hepatitis A Virus Infection.	Bilirubin	11-20	CD4 molecule	Homo sapiens	53-56
29212810-8	2018	Furthermore, TNF-alpha-induced ET-1 production (TNF-alpha 31.0 +- 8.4 vs. untreated 7.5 +- 0.4 pg/ml, P &lt; 0.001) was reduced by CoPP (1.5 +- 0.8 pg/ml, P &lt; 0.001) and bilirubin (10.5 +- 4.3 pg/ml, P &lt; 0.001).	Bilirubin	173-182	tumor necrosis factor	Homo sapiens	13-22
29220881-6	2018	RESULTS: As expected, UGT1A1 genotypes were associated with baseline bilirubin levels (*1/*1 genotype: 9.1+-4.6 micromol/L; *1/*28 genotype: 10.8+-5.3; *28/*28: 16.9+-9.2; p&lt;0.001).	Bilirubin	69-78	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	22-28
29220881-8	2018	In a multivariate regression analysis adjusting for age, sex, smoking, type 2 diabetes, dyslipidemia, alanine aminotransferase (ALT) levels and bilirubin levels, the UGT1A1*28 variant predicted lower overall mortality (hazard ratio [HR], 0.86; 95% confidence interval [CI], 0.78-0.95; p=0.003).	Bilirubin	144-153	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	166-172
29220881-11	2018	The protective effect of the UGT1A1*28 variant likely includes mechanism other than bilirubin metabolism.	Bilirubin	84-93	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	29-35
29587773-12	2018	However, alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels in the DEB-TACE group were better than those in the cTACE group (p &lt; 0.05).	Bilirubin	73-82	ADAM metallopeptidase domain 17	Homo sapiens	101-105
29324279-0	2018	Inhibition of UDP-glucose dehydrogenase by 6-thiopurine and its oxidative metabolites: Possible mechanism for its interaction within the bilirubin excretion pathway and 6TP associated liver toxicity.	Bilirubin	137-146	UDP-glucose 6-dehydrogenase	Homo sapiens	14-39
29582357-6	2018	JCT and SNL appeared to correlate because preoperative total bilirubin (7.1, 9.6, 10.2 mg/dL; P &lt; 0.05) was significantly lower in the JCT &lt;= 30 days group (P &lt; 0.05) while there was a significant decrease in SNL (P &lt; 0.03) and a significant increase in LTx (P &lt; 0.01) in the JCT &gt;= 61 days group.	Bilirubin	61-70	fascin actin-bundling protein 1	Homo sapiens	8-11
29761173-7	2018	We found HNF4alpha expression was down-regulated and correlated well with the extent of liver dysfunction (P = 0.001), stage of fibrosis (P = 0.0005), and serum levels of total bilirubin (P = 0.009; r = 0.35), albumin (P &lt; 0.001; r = 0.52), and prothrombin time activity (P = 0.002; r = 0.41).	Bilirubin	177-186	hepatocyte nuclear factor 4 alpha	Homo sapiens	9-18
29310097-6	2018	Batch adsorption experiments for both free bilirubin solution and bovine serum albumin (BSA)-bonded bilirubin solution were studied.	Bilirubin	100-109	albumin	Homo sapiens	73-86
29212810-8	2018	Furthermore, TNF-alpha-induced ET-1 production (TNF-alpha 31.0 +- 8.4 vs. untreated 7.5 +- 0.4 pg/ml, P &lt; 0.001) was reduced by CoPP (1.5 +- 0.8 pg/ml, P &lt; 0.001) and bilirubin (10.5 +- 4.3 pg/ml, P &lt; 0.001).	Bilirubin	173-182	endothelin 1	Homo sapiens	31-35
30159383-5	2018	Specifically, we engineer a fluorescent fusion protein by fusing three copies of the PEST destruction domain of mouse ornithine decarboxylase (MODC) to the C-terminal end of the codon-optimized bilirubin-inducible fluorescent protein, designated as dBiFP, and show that the dBiFP protein is highly destabilized, compared with the commonly-used eGFP protein.	Bilirubin	194-203	ornithine decarboxylase, structural 1	Mus musculus	118-141
29278860-2	2018	Pretreatment of SAG attenuated the CCl4-toxicity induced elevation of liver injury markers such as enzymes (AST, ALT, GGT, ALP and LDH) and bilirubin in the blood circulation.	Bilirubin	140-149	S-antigen visual arrestin	Homo sapiens	16-19
28877352-6	2018	In a multiple linear regression analysis, lg(peak TBIL + 1) was significantly associated with lg(peak AST + 1) (b-coefficient 0.188, P = 0.001), lg(peak pFHb + 1) (b-coefficient 0.201, P = 0.003), and basic TBIL (b-coefficient 0.006, P = 0.009).	Bilirubin	50-54	glutamic-oxaloacetic transaminase 1	Homo sapiens	102-109
29395087-6	2018	The affinity for BR differed by three orders of magnitude between the Ca2+-free state (Kd = 9.70 nM) and Ca2+-saturated state (Kd = 9.65 muM).	Bilirubin	17-19	latexin	Homo sapiens	137-140
28971836-10	2018	In an acute model of CCl4 single injection, SAG inhibited hepatic injury dose dependently consistent with the inhibited the elevation of the bilirubin and ALT levels.	Bilirubin	141-150	S-antigen visual arrestin	Rattus norvegicus	44-47
28877352-6	2018	In a multiple linear regression analysis, lg(peak TBIL + 1) was significantly associated with lg(peak AST + 1) (b-coefficient 0.188, P = 0.001), lg(peak pFHb + 1) (b-coefficient 0.201, P = 0.003), and basic TBIL (b-coefficient 0.006, P = 0.009).	Bilirubin	50-54	HBN1	Homo sapiens	153-161
28877352-6	2018	In a multiple linear regression analysis, lg(peak TBIL + 1) was significantly associated with lg(peak AST + 1) (b-coefficient 0.188, P = 0.001), lg(peak pFHb + 1) (b-coefficient 0.201, P = 0.003), and basic TBIL (b-coefficient 0.006, P = 0.009).	Bilirubin	207-211	glutamic-oxaloacetic transaminase 1	Homo sapiens	102-109
29195835-9	2018	These data show that Bvra-/- mice experience higher oxidative stress in blood, implying that plasma bilirubin attenuates endogenous oxidative stress.	Bilirubin	100-109	biliverdin reductase A	Mus musculus	21-25
28708313-1	2018	Human biliverdin reductase (hBVR), is an enzyme, that converts biliverdin to bilirubin, and has been implicated in epithelial-mesenchymal transition (EMT) in breast cancer.	Bilirubin	77-86	biliverdin reductase A	Homo sapiens	28-32
28833919-9	2018	RESULTS: Injection of IL-10 or MSC transplantation ameliorated D-Gal-induced increase in alanine aminotransferase, aspartate aminotransferase, total bilirubin, NH3, and inflammatory cytokines.	Bilirubin	149-158	interleukin 10	Mus musculus	22-27
29223776-7	2018	This significantly up-regulated the carlinoside induced expression of the bilirubin-solubilizing UGT1A1enzyme in HepG2 cell and rat liver.	Bilirubin	74-83	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	97-103
29619129-6	2018	Independent associations were found between the variant A allele and lower total cholesterol, between c2 allele and low alpha-1 antitrypsin and between the null GSTT1 variant and high indirect and total bilirubin in SCA-HU+ patients.	Bilirubin	203-212	glutathione S-transferase theta 1	Homo sapiens	161-166
29069498-0	2018	Transient Changes in Hepatic Physiology That Alter Bilirubin and Bile Acid Transport May Explain Elevations in Liver Chemistries Observed in Clinical Trials of GGF2 (Cimaglermin Alfa).	Bilirubin	51-60	GINGF2	Homo sapiens	160-164
29069498-2	2018	Phase 1 clinical trials of GGF2 were put on hold when transient elevations in serum aminotransferases and total bilirubin were observed in 2 of 43 subjects who received single doses of GGF2 at 1.5 or 0.378 mg/kg.	Bilirubin	112-121	GINGF2	Homo sapiens	27-31
29069498-4	2018	Cynomolgus monkeys administered a single 15 mg/kg dose of GGF2 had similar transient elevations in serum aminotransferases and bilirubin as well as transient elevations in serum bile acids.	Bilirubin	127-136	GINGF2	Homo sapiens	58-62
29069498-10	2018	Taken together, these data suggest that GGF2 does not cause significant hepatocellular death, but transiently modifies hepatic handling of bilirubin and bile acids, effects that may account for the elevations in serum bilirubin observed in the clinical trial subjects.	Bilirubin	139-148	GINGF2	Homo sapiens	40-44
29069498-10	2018	Taken together, these data suggest that GGF2 does not cause significant hepatocellular death, but transiently modifies hepatic handling of bilirubin and bile acids, effects that may account for the elevations in serum bilirubin observed in the clinical trial subjects.	Bilirubin	218-227	GINGF2	Homo sapiens	40-44
29249571-6	2018	The conversion of biliverdin to BR is catalyzed by biliverdin reductase-A (BVR-A).	Bilirubin	32-34	biliverdin reductase A	Homo sapiens	75-80
29375210-8	2018	The IRF5*TCAT haplotype was also associated with increased levels of ALT, AST and bilirubin.	Bilirubin	82-91	interferon regulatory factor 5	Homo sapiens	4-8
29357878-6	2018	RESULTS: Stimulation of the astrocytes with unconjugated bilirubin (UCB) at the conditions mimicking those of jaundiced newborns significantly increased the activation of caspase-1.	Bilirubin	57-66	caspase 1	Rattus norvegicus	171-180
29128834-4	2018	The adsorption results indicated that NPS-8 displayed better adsorption capacity for bilirubin (91%) than that of PS-8 (75.88%).	Bilirubin	85-94	taste 2 receptor member 15 pseudogene	Homo sapiens	39-43
28881095-5	2018	Albumin is a major blood transport protein, which mediates transport of many lipid soluble compounds including fatty acids, hormones, and bilirubin.	Bilirubin	138-147	albumin	Homo sapiens	0-7
29034998-8	2018	A more advanced albumin-bilirubin grade correlated with lower CD4 counts (464/373/288 cells/mm3 for grades 1/2/3) and higher HIV viraemia (3.337/8.701/61.845 copies/mL for grades 1/2/3, P &lt; .001).	Bilirubin	24-33	CD4 molecule	Homo sapiens	62-65
29155119-8	2018	Logistic regression analysis showed that, as compared with the lowest bilirubin tertile (0.1-0.4mg/dL), the highest tertile (0.7-2.7mg/dL) was significantly negatively associated with prevalent PAD after adjusting for sex, age, eGFR, white blood cell count, inorganic phosphate, HbA1C, total and HDL cholesterol, triglycerides, current smoking, diabetic medication, and statin use.	Bilirubin	70-79	epidermal growth factor receptor	Homo sapiens	228-232
30467439-7	2018	Bilirubin and albumin levels were lower in the serum of active CD patients than inactive CD patients and controls and negatively correlated with the CD activity index (r = -0328, p = 0.036, r = -0.518, p = 0.002) and CRP (r = -0.433, p = 0.002).	Bilirubin	0-9	C-reactive protein	Homo sapiens	217-220
29424349-6	2018	NAC significantly decreased levels of bile acids and bilirubin in plasma and triacylglycerols in liver, all of them elevated by impairment with CCl4.	Bilirubin	53-62	X-linked Kx blood group	Homo sapiens	0-3
30039753-5	2018	Since heme oxygenase, via its products bilirubin and carbon monoxide, functions as a physiological inhibitor of various isoforms of NADPH oxidase, phase 2-inducing nutraceuticals with blood brain-barrier permeability such as lipoic acid, an effective inducer of heme oxygenase-1, may have potential for prevention of morphine tolerance; indeed, this has been demonstrated in a mouse study.	Bilirubin	39-48	heme oxygenase 1	Mus musculus	262-278
28719764-6	2018	Total bilirubin (P = .03) and liver pathology (P < .001) were greater in PN-fed than SF groups but not different between PN-fed groups.	Bilirubin	6-15	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	73-75
30175727-1	2018	A 27-year-old man bearing an erythropoietic protoporphyria (EPP)-associated ferrochelatase (FECH) mutation was admitted to our hospital for general malaise and marked elevation of the serum levels of hepatobiliary enzymes and bilirubin.	Bilirubin	226-235	ferrochelatase	Homo sapiens	60-63
30175727-1	2018	A 27-year-old man bearing an erythropoietic protoporphyria (EPP)-associated ferrochelatase (FECH) mutation was admitted to our hospital for general malaise and marked elevation of the serum levels of hepatobiliary enzymes and bilirubin.	Bilirubin	226-235	ferrochelatase	Homo sapiens	92-96
28719764-8	2018	PN-fed piglets with sepsis had lower bile flow (P = .001) and increased bilirubin (P = .04).	Bilirubin	72-81	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	0-2
29285194-5	2018	The CNP was associated with liver cirrhosis (P=0.015), Child-Pugh class (P=0.024), total bilirubin level (P=0.028), neutrophil count (P&lt;0.001), lymphocyte count (P&lt;0.001) and platelet count (P&lt;0.001).	Bilirubin	89-98	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	4-7
30497071-7	2018	Serum bilirubin significantly associated with serum albumin, and plasma hemoglobin.	Bilirubin	6-15	albumin	Homo sapiens	46-59
29117017-9	2018	CONCLUSION: Among patients who initiated atazanavir/ritonavir-containing regimens, UGT1A1 slow metabolizer genotype rs887829 T/T was associated with increased bilirubin-related discontinuation of atazanavir in White but not in Black patients, this despite T/T genotype being more frequent in Black patients.	Bilirubin	159-168	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	83-89
29207378-8	2018	Turkish patients thus have distinct patterns of presentation, but the biological relationships between MTD and both platelets and bilirubin levels are similar to the relationships that have been reported in other ethnic patient groups.	Bilirubin	130-139	metallothionein 1E	Homo sapiens	103-106
28805483-0	2018	Tet1-mediated DNA demethylation involves in neuron damage induced by bilirubin in vitro.	Bilirubin	69-78	tet methylcytosine dioxygenase 1	Homo sapiens	0-4
28805483-1	2018	The aim of this study is to identify the role of Tet1-mediated DNA demethylation in the neurotoxicity caused by unconjugated bilirubin (UCB) in vitro.	Bilirubin	125-134	tet methylcytosine dioxygenase 1	Homo sapiens	49-53
29292263-5	2017	In HCC patients, plasma MBL level was positively correlated with vascular invasion (r=0.253, P=0.047) and total bilirubin level (r=0.283, P=0.024).	Bilirubin	112-121	mannose binding lectin 2	Homo sapiens	24-27
29416664-5	2018	Direct bilirubin (DBIL) levels were correlated with tumor progression and response to first-line platinum-based chemotherapy, and were associated with OS after adjusting for TNM stage.	Bilirubin	7-16	teneurin transmembrane protein 1	Homo sapiens	174-177
29247156-8	2017	Neonatal bilirubin-induced neurotoxicity was validated by significantly decreased serum BDNF, brain BDNF, and serum S100B, along with significantly increased serum tau protein (p&lt;0.05).	Bilirubin	9-18	brain-derived neurotrophic factor	Rattus norvegicus	88-92
29247156-8	2017	Neonatal bilirubin-induced neurotoxicity was validated by significantly decreased serum BDNF, brain BDNF, and serum S100B, along with significantly increased serum tau protein (p&lt;0.05).	Bilirubin	9-18	brain-derived neurotrophic factor	Rattus norvegicus	100-104
29247156-8	2017	Neonatal bilirubin-induced neurotoxicity was validated by significantly decreased serum BDNF, brain BDNF, and serum S100B, along with significantly increased serum tau protein (p&lt;0.05).	Bilirubin	9-18	S100 calcium binding protein B	Rattus norvegicus	116-121
28756878-1	2017	Heme oxygenase-1 (HO-1) is the enzyme catalyzing the rate-limiting oxidative degradation of cellular heme into free iron, carbon monoxide (CO), and biliverdin, which is then rapidly converted into bilirubin.	Bilirubin	197-206	heme oxygenase 1	Homo sapiens	0-16
28756878-1	2017	Heme oxygenase-1 (HO-1) is the enzyme catalyzing the rate-limiting oxidative degradation of cellular heme into free iron, carbon monoxide (CO), and biliverdin, which is then rapidly converted into bilirubin.	Bilirubin	197-206	heme oxygenase 1	Homo sapiens	18-22
29125289-0	2017	A Practical and High-Affinity Fluorescent Probe for Uridine Diphosphate Glucuronosyltransferase 1A1: A Good Surrogate for Bilirubin.	Bilirubin	122-131	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	52-99
29125289-4	2017	Both inhibition kinetic analyses and molecular docking simulations demonstrated that 2 could bind on UGT1A1 at the same ligand-binding site as bilirubin.	Bilirubin	143-152	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	101-107
29125289-6	2017	In conclusion, a practical and high-affinity fluorescent probe for UGT1A1 was designed and well-characterized, which could serve as a good surrogate for bilirubin to investigate UGT1A1-ligand interactions.	Bilirubin	153-162	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	67-73
28927974-6	2017	In BA, the higher staining density of CD163 and CD68 was related with elevated serum conjugated bilirubin level (p=0.014 and 0.021, respectively).	Bilirubin	96-105	CD163 molecule	Homo sapiens	38-43
33445377-3	2017	Prompted by the dynamic interaction between bilirubin and bovine serum albumin (BSA), bilirubin-BSA complex was explored as a biocompatible cap system for protease responsive delivery device of anticancer drug against colon cancer.	Bilirubin	44-53	albumin	Homo sapiens	65-78
33445377-3	2017	Prompted by the dynamic interaction between bilirubin and bovine serum albumin (BSA), bilirubin-BSA complex was explored as a biocompatible cap system for protease responsive delivery device of anticancer drug against colon cancer.	Bilirubin	86-95	albumin	Homo sapiens	65-78
28927974-6	2017	In BA, the higher staining density of CD163 and CD68 was related with elevated serum conjugated bilirubin level (p=0.014 and 0.021, respectively).	Bilirubin	96-105	CD68 molecule	Homo sapiens	48-52
29133521-10	2017	A genetic variant at the UGT1A1*28 locus consistently shown to be strongly associated with circulating bilirubin levels-rs6742078-was not significantly associated with blood pressure or hypertension (P&gt;0.05 for all), arguing against a strong causal association of circulating bilirubin with blood pressure.	Bilirubin	103-112	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	25-31
29025858-1	2017	Human UDP-glucuronosyltransferase 1A1 (UGT1A1) is a unique enzyme involved in bilirubin conjugation.	Bilirubin	78-87	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	6-37
29025858-1	2017	Human UDP-glucuronosyltransferase 1A1 (UGT1A1) is a unique enzyme involved in bilirubin conjugation.	Bilirubin	78-87	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	39-45
29170479-5	2017	The beneficial effect of CORM-2 was blocked by an NF-kappaB inhibitor, a miR-155-5p mimic, a HO-1 inhibitor and siRNA against HO-1, indicating that CO rescues TNF-alpha-induced eNOS downregulation through NF-kappaB-responsive miR-155-5p expression via HO-1 induction; similar protective effects of ectopic HO-1 expression and bilirubin were observed in endothelial cells treated with TNF-alpha.	Bilirubin	326-335	tumor necrosis factor	Homo sapiens	159-168
29105594-1	2017	BACKGROUND: In a previous trial involving patients with early autosomal dominant polycystic kidney disease (ADPKD; estimated creatinine clearance, &gt;=60 ml per minute), the vasopressin V2-receptor antagonist tolvaptan slowed the growth in total kidney volume and the decline in the estimated glomerular filtration rate (GFR) but also caused more elevations in aminotransferase and bilirubin levels.	Bilirubin	383-392	arginine vasopressin receptor 2	Homo sapiens	175-198
29264426-0	2017	Albumin-to-bilirubin score for assessing the in-hospital death in cirrhosis.	Bilirubin	11-20	albumin	Homo sapiens	0-7
29276688-4	2018	The results had shown the elevated level of AST (121.16%), ALT (124.68%), ALP (122.41%) an, bilirubin content (57.14%) after CCl4 treatment.	Bilirubin	92-101	C-C motif chemokine ligand 4	Rattus norvegicus	125-129
29338386-0	2017	Estrogen-Estrogen Receptor alpha Signaling Facilitates Bilirubin Metabolism in Regenerating Liver Through Regulating Cytochrome P450 2A6 Expression.	Bilirubin	55-64	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	117-136
29163550-4	2017	AAT showed negative correlation with red blood cells, hemoglobin (Hb), hematocrit, high-density lipoprotein cholesterol, urea, creatinine, and albumin and was positively correlated with mean corpuscular Hb concentration, white blood cells, neutrophils, Hb S, bilirubin, lactate dehydrogenase, ferritin, and C-reactive protein.	Bilirubin	259-268	serpin family A member 1	Homo sapiens	0-3
29338386-8	2017	In the PHx mouse model, the expression of the cyp2a4 gene was significantly lower in livers from the knockout ERalpha mice than in livers from their wild-type littermates; but the expression of other bilirubin metabolism-related genes were similar between these groups.	Bilirubin	200-209	cytochrome P450, family 2, subfamily a, polypeptide 4	Mus musculus	46-52
29338386-9	2017	Moreover, E2 or bilirubin treatments significantly promoted CYP2A6 expression in hepatocyte progenitor cells (HepRG cells).	Bilirubin	16-25	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	60-66
29338386-11	2017	CONCLUSIONS: This is the first report to demonstrate, on a molecular level, that E2/ERalpha signaling facilitates bilirubin metabolism in regenerating liver.	Bilirubin	114-123	cystatin 12, pseudogene	Homo sapiens	81-91
28177535-8	2017	Spearman rank test further demonstrated that IgG and ESR were negative associated with total, indirect bilirubin, and albumin, prealbumin, APOA, HDL-C were positively associated with bilirubin.	Bilirubin	183-192	apolipoprotein A1	Homo sapiens	139-143
27785826-7	2017	The relative uptake rate Kir derived from this model was found to be significantly correlated with direct bilirubin (r = -0.52, P = 0.015), prealbumin concentration (r = 0.58, P = 0.015), and prothrombin time (r = -0.51, P = 0.026).	Bilirubin	106-115	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	25-28
28797660-0	2017	Evaluation of genetic effect of NOS3 and GxE interaction on the variability of serum bilirubin in a Han Chinese population.	Bilirubin	85-94	nitric oxide synthase 3	Homo sapiens	32-36
28797660-1	2017	Bilirubin was shown to be related to the generation and functional exertion of endothelial nitric oxide synthase (eNOS) whilst the genetic effect of NOS3 on bilirubin variability was rarely reported.	Bilirubin	0-9	nitric oxide synthase 3	Homo sapiens	79-112
28797660-1	2017	Bilirubin was shown to be related to the generation and functional exertion of endothelial nitric oxide synthase (eNOS) whilst the genetic effect of NOS3 on bilirubin variability was rarely reported.	Bilirubin	157-166	nitric oxide synthase 3	Homo sapiens	149-153
28797660-2	2017	Herein we assessed the associations of three single nucleotide polymorphisms (SNPs) of NOS3 (rs4496877, rs1808593, and rs3918186) with bilirubin elevation in 2077 adults.	Bilirubin	135-144	nitric oxide synthase 3	Homo sapiens	87-91
28797660-9	2017	Our findings supported that NOS3 harbors the genetic susceptibility to the bilirubin elevation.	Bilirubin	75-84	nitric oxide synthase 3	Homo sapiens	28-32
28797660-10	2017	Age, gender, smoking, and drinking could be involved in the genetic modification of NOS3 on the bilirubin variability.	Bilirubin	96-105	nitric oxide synthase 3	Homo sapiens	84-88
28859949-5	2017	A Cox regression model showed that increased serum transaminase and bilirubin levels at the time of hepatic artery thrombosis diagnosis, but not nonrevascularization treatment versus revascularization, were risk factors for the development of ischemic cholangiopathy.	Bilirubin	68-77	cytochrome c oxidase subunit 8A	Homo sapiens	2-5
29379592-8	2017	TLR4 showed a positive correlation with age, fibrosis stage, HCV RNA, serum transaminases, total bilirubin and prothrombin time, a negative correlation with platelet count and serum albumin.	Bilirubin	97-106	toll like receptor 4	Homo sapiens	0-4
29042644-3	2017	Vpr-Tg mice developed increased liver triglyceride content and elevated ALT, bilirubin and alkaline phosphatase due to three hepatic defects: 1.6-fold accelerated de novo lipogenesis (DNL), 45% slower fatty acid ss-oxidation, and 40% decreased VLDL-triglyceride export.	Bilirubin	77-86	Vpr	Human immunodeficiency virus 1	0-6
28805798-2	2017	Crigler-Najjar Syndrome Type I is a rare monogenic disease with neonatal onset, caused by mutations in the liver-specific UGT1 gene, with toxic accumulation of unconjugated bilirubin in plasma, tissues and brain.	Bilirubin	173-182	UDP glucuronosyltransferase 1 family, polypeptide A2	Mus musculus	122-126
29399656-1	2017	Neurotoxic bilirubin is solely conjugated by UDP-glucuronosyltransferase (UGT) 1A1.	Bilirubin	11-20	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	45-82
29399656-9	2017	Deletion of Ugt1a1 results in neonatal lethality from bilirubin neurotoxicity.	Bilirubin	54-63	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	12-18
29399656-11	2017	When zinc protoporphyrin, an inhibitor of heme oxygenase I, was administered to newborn Ugt1-/- mice, serum bilirubin levels dropped dramatically, rescuing the mice from bilirubin-induced neonatal lethality.	Bilirubin	108-117	UDP glucuronosyltransferase 1 family, polypeptide A2	Mus musculus	88-92
28547076-11	2017	As a recent example, upregulation of CD39 is dependent upon ligation of the aryl hydrocarbon receptor (AHR), as with natural ligands such as bilirubin and 2-(1" H-indole-3"-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE).	Bilirubin	141-150	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	37-41
28722105-8	2017	Otherwise, serum CXCL16 levels positively correlated with nonalcoholic fatty liver disease (NAFLD), alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transpeptidase (GGT) and direct bilirubin (P &lt; 0 05), but negatively with total protein and albumin after adjustment with age and gender.	Bilirubin	223-232	C-X-C motif chemokine ligand 16	Homo sapiens	17-23
28954507-10	2017	The use of the multiple-variable model demonstrated that the independent factors affecting the concentration of ENG were the concentration of bilirubin (p=0.02), INR (p=0.01) and duration of alcohol abuse (p=0.02).	Bilirubin	142-151	endoglin	Homo sapiens	112-115
28831805-1	2017	Free bilirubin, a key biomarker for jaundice, was detected with a newly designed fluorescent postsynthetically modified metal organic framework (MOF) (UIO-66-PSM) sensor.	Bilirubin	5-14	lysine acetyltransferase 8	Homo sapiens	120-149
28831805-1	2017	Free bilirubin, a key biomarker for jaundice, was detected with a newly designed fluorescent postsynthetically modified metal organic framework (MOF) (UIO-66-PSM) sensor.	Bilirubin	5-14	folate hydrolase 1B (pseudogene)	Homo sapiens	158-161
28831805-3	2017	The fluorescence of UIO-66-PSM could be effectively quenched by free bilirubin via a fluorescent resonant energy transfer process, thus achieving its recognition of free bilirubin.	Bilirubin	69-78	folate hydrolase 1B (pseudogene)	Homo sapiens	27-30
28831805-3	2017	The fluorescence of UIO-66-PSM could be effectively quenched by free bilirubin via a fluorescent resonant energy transfer process, thus achieving its recognition of free bilirubin.	Bilirubin	170-179	folate hydrolase 1B (pseudogene)	Homo sapiens	27-30
28831805-4	2017	It was the first attempt to design a MOF-based fluorescent probe for sensing free bilirubin.	Bilirubin	82-91	lysine acetyltransferase 8	Homo sapiens	37-40
28603997-0	2017	Inhibition of Human UGT1A1-Mediated Bilirubin Glucuronidation by Polyphenolic Acids Impact Safety of Popular Salvianolic Acid A/B-Containing Drugs and Herbal Products.	Bilirubin	36-45	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	20-26
28603997-3	2017	The purpose of this article is to determine the mechanism by which certain polyphenolic acids inhibit UGT1A1-mediated bilirubin glucuronidation, leading to jaundice or hyperbilirubinemia.	Bilirubin	118-127	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	102-108
28603997-4	2017	We investigated in vitro inhibitory effects on bilirubin glucuronidation of salvianolic acid A (SAA), salvianolic acid B (SAB), danshensu (DSS), protocatechuic aldehyde (PA), and rosmarinic acid (RA), as well as two Salvia miltiorrhiza injections (DSI and CDI) rich in polyphenolic acids.	Bilirubin	47-56	serum amyloid A1 cluster	Homo sapiens	96-99
28603997-6	2017	SAA, SAB, DSI, and CDI, but not DSS, PA, and RA, significantly inhibited human UGT1A1-mediated bilirubin glucuronidation via a mixed-type inhibitory mechanism.	Bilirubin	95-104	serum amyloid A1 cluster	Homo sapiens	0-3
28603997-6	2017	SAA, SAB, DSI, and CDI, but not DSS, PA, and RA, significantly inhibited human UGT1A1-mediated bilirubin glucuronidation via a mixed-type inhibitory mechanism.	Bilirubin	95-104	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	79-85
28603997-8	2017	In conclusion, SAA and its analog SAB are the main ingredients responsible for inhibition of bilirubin glucuronidation by DSI and CDI, whose use is associated with many high bilirubin-related ADR.	Bilirubin	93-102	serum amyloid A1 cluster	Homo sapiens	15-18
28603997-8	2017	In conclusion, SAA and its analog SAB are the main ingredients responsible for inhibition of bilirubin glucuronidation by DSI and CDI, whose use is associated with many high bilirubin-related ADR.	Bilirubin	174-183	serum amyloid A1 cluster	Homo sapiens	15-18
28547076-11	2017	As a recent example, upregulation of CD39 is dependent upon ligation of the aryl hydrocarbon receptor (AHR), as with natural ligands such as bilirubin and 2-(1" H-indole-3"-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE).	Bilirubin	141-150	aryl hydrocarbon receptor	Homo sapiens	76-101
28547076-11	2017	As a recent example, upregulation of CD39 is dependent upon ligation of the aryl hydrocarbon receptor (AHR), as with natural ligands such as bilirubin and 2-(1" H-indole-3"-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE).	Bilirubin	141-150	aryl hydrocarbon receptor	Homo sapiens	103-106
28124283-6	2017	Moreover, following bile duct ligation, LAMP-2-deficient rats develop rapid and severe evidence of advanced cholestasis, with an increase in serum bilirubin, as early as 6 h later.	Bilirubin	147-156	lysosomal-associated membrane protein 2	Rattus norvegicus	40-46
28790431-5	2017	Conversely, ATRA differentiated cells exposed to H2O2 showed a significantly lower induction of HO-1, and only the supplementation with low doses of bilirubin (0,5-1 muM) restored viability.	Bilirubin	149-158	latexin	Homo sapiens	166-169
28124283-7	2017	In wild-type control rats, multidrug resistance-associated protein 2 (Mrp2) normally concentrates at the bile canalicular membranes to secrete conjugated bilirubin into bile.	Bilirubin	154-163	ATP binding cassette subfamily C member 2	Rattus norvegicus	27-68
28124283-7	2017	In wild-type control rats, multidrug resistance-associated protein 2 (Mrp2) normally concentrates at the bile canalicular membranes to secrete conjugated bilirubin into bile.	Bilirubin	154-163	ATP binding cassette subfamily C member 2	Rattus norvegicus	70-74
28056490-9	2017	Unconjugated bilirubin and ammonia were or tended to be elevated in Fut2-/-high mice only.	Bilirubin	13-22	fucosyltransferase 2	Mus musculus	68-72
28763300-1	2017	Background Hmox1 plays an important role in the regulation of mitochondrial bioenergetics and function by regulating cellular heme-derived CO and bilirubin.	Bilirubin	146-155	heme oxygenase 1	Mus musculus	11-16
28638943-10	2017	Moreover, serum HSP70 was positively correlated with serum aspartate aminotransferase (r = 0.491, P &lt; 0.001), alanine aminotransferase (r = 0.448, P &lt; 0.001), total bilirubin (r = 0.303, P = 0.002), alkaline phosphatase (r = 0.414, P &lt; 0.001), and liver stiffness values (r = 0.455, P &lt; 0.001).	Bilirubin	171-180	heat shock protein family A (Hsp70) member 4	Homo sapiens	16-21
28206992-2	2017	Heme oxygenase-1 (HO-1) is the rate-limiting enzyme by which heme is catabolized to biliverdin and thence to bilirubin, with the simultaneous release of equimolar quantities of ferrous iron (Fe3+) and carbon monoxide.	Bilirubin	109-118	heme oxygenase 1	Homo sapiens	0-16
28206992-2	2017	Heme oxygenase-1 (HO-1) is the rate-limiting enzyme by which heme is catabolized to biliverdin and thence to bilirubin, with the simultaneous release of equimolar quantities of ferrous iron (Fe3+) and carbon monoxide.	Bilirubin	109-118	heme oxygenase 1	Homo sapiens	18-22
28206992-3	2017	Polymorphisms of the HO-1 gene promoter may modulate transcriptional activity, thereby augmenting or attenuating HO-1 expression with resultant modulation of the production of bilirubin.	Bilirubin	176-185	heme oxygenase 1	Homo sapiens	21-25
28206992-5	2017	In this clinical review, we surveyed the role of HO-1 gene promoter polymorphisms in the control of bilirubin production and further considered their role, if any, in the pathophysiology of neonatal hyperbilirubinemia.	Bilirubin	100-109	heme oxygenase 1	Homo sapiens	49-53
28567595-0	2017	Do Alpha Thalassemia, Fetal Hemoglobin, and the UGT1A1 Polymorphism have an Influence on Serum Bilirubin Levels and Cholelithiasis in Patients with Sickle Cell Disease?	Bilirubin	95-104	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	48-54
28567595-2	2017	OBJECTIVES: The objective of this study was to determine the combined influence of alpha thalassemia, fetal hemoglobin, and the UGT1A1 polymorphism on serum bilirubin levels and cholelithiasis in patients with sickle cell disease.	Bilirubin	157-166	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	128-134
28567595-6	2017	Bilirubin levels were influenced by the UGT1A1 polymorphism but not by alpha thalassemia and fetal hemoglobin.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	40-46
28567595-8	2017	CONCLUSION: These preliminary findings suggest that the UGT1A1 gene can influence serum bilirubin levels in sickle cell anemia and serve as a tool to differentiate an acute hemolytic condition from a pre-existing condition of hyperbilirubinemia.	Bilirubin	88-97	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	56-62
28644197-8	2017	The GSA-Rmax was significantly correlated with liver functional parameters of ICGR15, LHL15, HH15, platelet count, prothrombin activity, and serum hyaluronic acid level (P&lt;0.01), and was significantly correlated with postoperative total bilirubin level and C-reactive protein level (P&lt;0.05).	Bilirubin	240-249	GNAS complex locus	Homo sapiens	4-7
28727814-11	2017	PCSK9 was negatively correlated with markers of liver function and cholestasis (INR, bilirubin).	Bilirubin	85-94	proprotein convertase subtilisin/kexin type 9	Homo sapiens	0-5
28248534-8	2017	D-GalN/LPS treatment upregulated HO-1 expression, downregulated SIRT1 expression, decreased AST: ALT ratio and markedly increased bilirubin, catalase and conjugated diene levels.	Bilirubin	130-139	galanin and GMAP prepropeptide	Rattus norvegicus	2-6
28978042-1	2017	Heme oxygenase-1 (HO-1) degrades heme to bilirubin.	Bilirubin	41-50	heme oxygenase 1	Homo sapiens	0-16
28892962-2	2017	It is caused by mutations in the UGT1A1 gene which codes for the enzyme uridine diphosphate glucoronosyl transferase- 1, required for the conjugation and further excretion of bilirubin from the body.	Bilirubin	175-184	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	33-39
28347842-2	2017	The enzyme heme oxygenase-1 (HO-1), involved in the degradation of heme, forms carbon monoxide (CO), ferrous iron, and bilirubin in conjunction with biliverdin reductase, and is induced by various stimuli including oxidative stress and heavy metals.	Bilirubin	119-128	heme oxygenase 1	Homo sapiens	11-27
28347842-2	2017	The enzyme heme oxygenase-1 (HO-1), involved in the degradation of heme, forms carbon monoxide (CO), ferrous iron, and bilirubin in conjunction with biliverdin reductase, and is induced by various stimuli including oxidative stress and heavy metals.	Bilirubin	119-128	heme oxygenase 1	Homo sapiens	29-33
28448868-5	2017	Our results showed that the administration of CCl4 caused hepatotoxicity as monitored by the significant increase in the levels of hepatic markers enzymes (lactate dehydrogenase (LDH), Alkaline phosphatase (PAL), total bilirubin (TB) and Gamma glutamyl transferase (gammaGT) levels) and a decrease in hematological parameters such as white blood cell (WBC), red blood cell count (RBC), mean corpuscular hemoglobin concentration (MCHC) and blood platelet count (PLT).	Bilirubin	219-228	C-C motif chemokine ligand 4	Rattus norvegicus	46-50
28978042-1	2017	Heme oxygenase-1 (HO-1) degrades heme to bilirubin.	Bilirubin	41-50	heme oxygenase 1	Homo sapiens	18-22
28617443-3	2017	Here we report for the first time that bilirubin at a clinically relevant elevated level impairs proteasomal function via inhibiting both the 19S proteasome-associated deubiquitinases (USP14 and UCHL5) and the chymotrypsin-like (CT-like) peptidase activity of 20S proteasomes, thereby contributing to bilirubin neurotoxicity.	Bilirubin	39-48	ubiquitin specific peptidase 14	Rattus norvegicus	185-190
28617443-3	2017	Here we report for the first time that bilirubin at a clinically relevant elevated level impairs proteasomal function via inhibiting both the 19S proteasome-associated deubiquitinases (USP14 and UCHL5) and the chymotrypsin-like (CT-like) peptidase activity of 20S proteasomes, thereby contributing to bilirubin neurotoxicity.	Bilirubin	39-48	ubiquitin C-terminal hydrolase L5	Rattus norvegicus	195-200
28617443-8	2017	Finally, bilirubin in vitro directly inhibited both the deubiquitination activity of proteasome-associated USP14 and UCHL5 and the CT-like peptidase activity of purified 20S proteasomes, in a dose-dependent manner.	Bilirubin	9-18	ubiquitin specific peptidase 14	Rattus norvegicus	107-112
28617443-8	2017	Finally, bilirubin in vitro directly inhibited both the deubiquitination activity of proteasome-associated USP14 and UCHL5 and the CT-like peptidase activity of purified 20S proteasomes, in a dose-dependent manner.	Bilirubin	9-18	ubiquitin C-terminal hydrolase L5	Rattus norvegicus	117-122
28617446-9	2017	CTSL and CTSB levels increased with the Child-Pugh stage of liver cirrhosis and correlated with total bilirubin content (r=0.4/0.2; P&lt;=0.05).	Bilirubin	102-111	cathepsin L	Homo sapiens	0-4
28617446-9	2017	CTSL and CTSB levels increased with the Child-Pugh stage of liver cirrhosis and correlated with total bilirubin content (r=0.4/0.2; P&lt;=0.05).	Bilirubin	102-111	cathepsin B	Homo sapiens	9-13
29113390-4	2017	Studying the correlation of serum bilirubin levels with iron, zinc, copper and high-sensitivity C-reactive protein, we found positive correlations for iron and zinc, and negative correlations for high-sensitivity C-reactive protein and copper in whole participants.	Bilirubin	34-43	C-reactive protein	Homo sapiens	96-114
33429582-18	2017	This work has taken advantage of the host-guest self-assembly between beta-CD and BR/Ad for special recognizing adsorption, as well as the thermoresponse of beta-CD-Ad inclusion for recyclable application, and these results demonstrate that this technology has great potential for removing bilirubin and decreasing clinic costs.	Bilirubin	290-299	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	70-77
33429582-18	2017	This work has taken advantage of the host-guest self-assembly between beta-CD and BR/Ad for special recognizing adsorption, as well as the thermoresponse of beta-CD-Ad inclusion for recyclable application, and these results demonstrate that this technology has great potential for removing bilirubin and decreasing clinic costs.	Bilirubin	290-299	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	157-164
29113390-4	2017	Studying the correlation of serum bilirubin levels with iron, zinc, copper and high-sensitivity C-reactive protein, we found positive correlations for iron and zinc, and negative correlations for high-sensitivity C-reactive protein and copper in whole participants.	Bilirubin	34-43	C-reactive protein	Homo sapiens	213-231
28410854-4	2017	Serum bilirubin was found to be negatively correlated with C-reactive protein (CRP) concentration and erythrocyte sedimentation rate (ESR) (r=-0.165, P=0.030; r=-192, P=0.012) in patients with RA.	Bilirubin	6-15	C-reactive protein	Homo sapiens	59-77
28410854-4	2017	Serum bilirubin was found to be negatively correlated with C-reactive protein (CRP) concentration and erythrocyte sedimentation rate (ESR) (r=-0.165, P=0.030; r=-192, P=0.012) in patients with RA.	Bilirubin	6-15	C-reactive protein	Homo sapiens	79-82
28497756-17	2017	The most frequently reported adverse events were skin hyperpigmentation (123 [55%] of 222 patients in the S-1 group vs nine [8%] of 111 patients in the placebo group), decreased appetite (104 [47%] vs 21 [19%]), fatigue (102 [46%] vs 20 [18%]), diarrhoea (77 [35%] vs 14 [13%]), and increased blood bilirubin (77 [35%] vs 14 [13%]).	Bilirubin	299-308	proteasome 26S subunit, non-ATPase 1	Homo sapiens	106-109
28560357-4	2017	Furthermore, free heme induces expression of heme oxygenase-1 to increase production of CO, biliverdin and bilirubin.	Bilirubin	107-116	heme oxygenase 1	Mus musculus	45-61
28213806-4	2017	The presence of two UGT1A1 variants (consistent with Gilbert or Crigler-Najjar syndrome) occurred less frequently in neonates (aged &lt;=28 days) than older children (aged 1-18 years) (31.3% in neonates vs. 85.1%, p &lt; 0.0001), and among neonates there was no significant difference in mean total bilirubin between those with two UGT1A1 variants and those without (p = 0.47).	Bilirubin	299-308	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	20-26
28449563-8	2017	The waist circumference and triglyceride criteria for MetS were significantly related to low serum direct bilirubin at baseline; waist circumference and fasting glucose criteria, and insulin resistance were associated with low serum direct bilirubin at follow-up.	Bilirubin	240-249	insulin	Homo sapiens	183-190
28393244-0	2017	Constitutive androstane receptor activation promotes bilirubin clearance in a murine model of alcoholic liver disease.	Bilirubin	53-62	nuclear receptor subfamily 1, group I, member 3	Mus musculus	0-32
28393244-2	2017	The constitutive androstane receptor (CAR) is a known xenobiotic receptor, which induces the detoxification and transport of bilirubin.	Bilirubin	125-134	nuclear receptor subfamily 1, group I, member 3	Mus musculus	4-36
28393244-2	2017	The constitutive androstane receptor (CAR) is a known xenobiotic receptor, which induces the detoxification and transport of bilirubin.	Bilirubin	125-134	nuclear receptor subfamily 1, group I, member 3	Mus musculus	38-41
28393244-5	2017	The results showed that chronic ethanol ingestion impaired the nuclear translocation of CAR, which was accompanied by elevated serum levels of bilirubin, suppression of the expression of hepatic and renal organic anion transporting polypeptide (OATP) 1A1 and hepatic multidrug resistance-associated protein 2 (MRP2), and induction of the expression of UDP-glucuronosyltransferase (UGT) 1A1.	Bilirubin	143-152	nuclear receptor subfamily 1, group I, member 3	Mus musculus	88-91
28393244-6	2017	The activation of CAR by TCPOBOP and PB resulted in downregulation of the serum levels of bilirubin followed by selective upregulation of the expression levels of OATP1A1, OATP1A4, UGT1A1 and MRP2 in ALD.	Bilirubin	90-99	nuclear receptor subfamily 1, group I, member 3	Mus musculus	18-21
28393244-7	2017	These results revealed the bilirubin transport regulatory mechanisms and highlighted the importance of CAR in modulating the bilirubin clearance pathway in the ALD mouse model.	Bilirubin	125-134	nuclear receptor subfamily 1, group I, member 3	Mus musculus	103-106
28559907-7	2017	Furthermore, carbon monoxide and bilirubin, catalytic products of HO1, partially rescue the boron toxicity-induced inhibition of primary root growth in shb1.	Bilirubin	33-42	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	66-69
28027587-3	2017	Serum total bilirubin decreased after PEBD in FIC1 (8.1 +- 4.0 vs. 2.9 +- 4.1 mg/dL, preoperatively vs. 12-24 months postoperatively, respectively; P = 0.02), but not in ALGS or BSEP.	Bilirubin	12-21	ATPase phospholipid transporting 8B1	Homo sapiens	46-50
28559907-7	2017	Furthermore, carbon monoxide and bilirubin, catalytic products of HO1, partially rescue the boron toxicity-induced inhibition of primary root growth in shb1.	Bilirubin	33-42	EXS (ERD1/XPR1/SYG1) family protein	Arabidopsis thaliana	152-156
28469075-0	2017	Bilirubin suppresses Th17 immunity in colitis by upregulating CD39.	Bilirubin	0-9	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	62-66
28283555-3	2017	Although neonatal jaundice is mostly benign, excessively high levels of serum bilirubin in a small percentage of newborns can cause bilirubin-induced neurologic dysfunction, potentially leading to permanent brain damage, a condition known as kernicterus Although a large portion of hyperbilirubinemia cases in newborns are associated with hemolytic diseases, we emphasize here the impaired ability of UGT1A1 to eliminate bilirubin that contributes to hyperbilirubinemia-induced neurotoxicity in the developmental stage.	Bilirubin	78-87	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	401-407
28283555-3	2017	Although neonatal jaundice is mostly benign, excessively high levels of serum bilirubin in a small percentage of newborns can cause bilirubin-induced neurologic dysfunction, potentially leading to permanent brain damage, a condition known as kernicterus Although a large portion of hyperbilirubinemia cases in newborns are associated with hemolytic diseases, we emphasize here the impaired ability of UGT1A1 to eliminate bilirubin that contributes to hyperbilirubinemia-induced neurotoxicity in the developmental stage.	Bilirubin	132-141	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	401-407
28283555-3	2017	Although neonatal jaundice is mostly benign, excessively high levels of serum bilirubin in a small percentage of newborns can cause bilirubin-induced neurologic dysfunction, potentially leading to permanent brain damage, a condition known as kernicterus Although a large portion of hyperbilirubinemia cases in newborns are associated with hemolytic diseases, we emphasize here the impaired ability of UGT1A1 to eliminate bilirubin that contributes to hyperbilirubinemia-induced neurotoxicity in the developmental stage.	Bilirubin	132-141	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	401-407
27442719-5	2017	In patients with ACHBLF, GSTM3 methylation level percentage of methylated reference (PMR) positively correlated with total bilirubin, international normalized ratio, and Model for End-stage Liver Disease (MELD) score, and negatively correlated with prothrombin activity and albumin (all P &lt; 0.05).	Bilirubin	123-132	glutathione S-transferase mu 3	Homo sapiens	25-30
28283555-2	2017	Owing to the fact that bilirubin is metabolized solely through glucuronidation by UDP-glucuronosyltransferase (UGT) 1A1, it is now known that immaturity of UGT1A1, in combination with the overproduction of bilirubin during the developmental stage, acts as a bottleneck to bilirubin elimination and predisposes the infant to high total serum bilirubin levels.	Bilirubin	23-32	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	82-119
28283555-2	2017	Owing to the fact that bilirubin is metabolized solely through glucuronidation by UDP-glucuronosyltransferase (UGT) 1A1, it is now known that immaturity of UGT1A1, in combination with the overproduction of bilirubin during the developmental stage, acts as a bottleneck to bilirubin elimination and predisposes the infant to high total serum bilirubin levels.	Bilirubin	23-32	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	156-162
28522909-15	2017	CDAE (160 and 320 mg/kg) significantly prevented CCl4-induced elevations of alkaline phosphatase, glutamate pyruvate transaminase, aspartate aminotransferase, and total bilirubin levels in rats of both sexes (P &lt; 0.05, 0.01, or 0.001).	Bilirubin	169-178	C-C motif chemokine ligand 4	Rattus norvegicus	49-53
28653915-5	2017	The administration of CCl4 and AAP caused significant (p&lt;0.05) elevation in liver enzymes; alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and other biochemical parameters, bilirubin, glucose, triglyceride and kidney function markers: urea and creatinine.	Bilirubin	250-259	C-C motif chemokine ligand 4	Rattus norvegicus	22-26
28494544-7	2017	In AIH patients, the positive rate of PD-1 in liver tissue was positively correlated with the levels of total bilirubin, alanine aminotransferase, aspartate aminotransferase, and IgG (r = 0.665, 0.721, 0.711, and 0.813, all P &lt; 0.01).	Bilirubin	110-119	programmed cell death 1	Homo sapiens	38-42
28455345-0	2017	Bilirubin Decreases Macrophage Cholesterol Efflux and ATP-Binding Cassette Transporter A1 Protein Expression.	Bilirubin	0-9	ATP binding cassette subfamily A member 1	Homo sapiens	54-89
28455345-5	2017	Unconjugated bilirubin (3-17.1 mumol/L) exogenously added to plasma- or apolipoprotein A1-supplemented media also decreased macrophage cholesterol efflux in a concentration- and time-dependent manner.	Bilirubin	13-22	apolipoprotein A1	Homo sapiens	72-89
28455345-6	2017	We also showed reduced protein expression of the ATP-binding cassette transporter A1 (ABCA1), a transmembrane cholesterol transporter involved in apolipoprotein A1-mediated cholesterol efflux, in THP-1 macrophages treated with unconjugated bilirubin and in peripheral blood mononuclear cells obtained from hyperbilirubinemic individuals.	Bilirubin	240-249	ATP binding cassette subfamily A member 1	Homo sapiens	49-84
28455345-6	2017	We also showed reduced protein expression of the ATP-binding cassette transporter A1 (ABCA1), a transmembrane cholesterol transporter involved in apolipoprotein A1-mediated cholesterol efflux, in THP-1 macrophages treated with unconjugated bilirubin and in peripheral blood mononuclear cells obtained from hyperbilirubinemic individuals.	Bilirubin	240-249	ATP binding cassette subfamily A member 1	Homo sapiens	86-91
28455345-6	2017	We also showed reduced protein expression of the ATP-binding cassette transporter A1 (ABCA1), a transmembrane cholesterol transporter involved in apolipoprotein A1-mediated cholesterol efflux, in THP-1 macrophages treated with unconjugated bilirubin and in peripheral blood mononuclear cells obtained from hyperbilirubinemic individuals.	Bilirubin	240-249	GLI family zinc finger 2	Homo sapiens	196-201
28455345-7	2017	Furthermore, we demonstrated that bilirubin accelerates the degradation rate of the ABCA1 protein in THP-1 macrophages.	Bilirubin	34-43	ATP binding cassette subfamily A member 1	Homo sapiens	84-89
28455345-7	2017	Furthermore, we demonstrated that bilirubin accelerates the degradation rate of the ABCA1 protein in THP-1 macrophages.	Bilirubin	34-43	GLI family zinc finger 2	Homo sapiens	101-106
28455345-9	2017	A direct effect of unconjugated bilirubin on cholesterol efflux was demonstrated and is associated with decreased ABCA1 protein expression.	Bilirubin	32-41	ATP binding cassette subfamily A member 1	Homo sapiens	114-119
28262508-8	2017	Moreover, down-regulation of Mrp2 blocked the excretion of bilirubin, glutathione disulfide, and bile acids, leading to the accumulation of toxic substrates in the liver and a redox imbalance.	Bilirubin	59-68	prolactin family 2, subfamily c, member 3	Mus musculus	29-33
28096081-1	2017	Gilbert"s syndrome in humans is derived from a polymorphism (TA repeat) in the hepatic UGT1A1 gene that results in decreased conjugation and increased levels of unconjugated bilirubin.	Bilirubin	174-183	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	87-93
28096081-2	2017	Recently, we have shown that bilirubin binds directly to the fat-burning nuclear peroxisome proliferator-activated receptor-alpha (PPARalpha).	Bilirubin	29-38	peroxisome proliferator activated receptor alpha	Mus musculus	81-129
28096081-2	2017	Recently, we have shown that bilirubin binds directly to the fat-burning nuclear peroxisome proliferator-activated receptor-alpha (PPARalpha).	Bilirubin	29-38	peroxisome proliferator activated receptor alpha	Mus musculus	131-140
28422158-3	2017	UGT1A1, the sole enzyme responsible for the metabolism of bilirubin, can be induced following activation of Nrf2.	Bilirubin	58-67	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	0-6
28422158-3	2017	UGT1A1, the sole enzyme responsible for the metabolism of bilirubin, can be induced following activation of Nrf2.	Bilirubin	58-67	nuclear factor, erythroid derived 2, like 2	Mus musculus	108-112
28422158-4	2017	When neonatal humanized UGT1 (hUGT1) mice, which exhibit severe levels of total serum bilirubin (TSB) because of a developmental delay in expression of the UGT1A1 gene, were treated with PEITC, TSB levels were reduced.	Bilirubin	86-95	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	30-35
30258914-4	2017	The expression of miR-4463 in the serum of HCC patients was significantly higher than that in control group (P &lt; 0.05), and the expression level was independent of gender, tumor size, cell types, stages, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL) and HBsAg status (P &gt; 0.05).	Bilirubin	279-288	microRNA 4463	Homo sapiens	18-26
30258914-4	2017	The expression of miR-4463 in the serum of HCC patients was significantly higher than that in control group (P &lt; 0.05), and the expression level was independent of gender, tumor size, cell types, stages, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL) and HBsAg status (P &gt; 0.05).	Bilirubin	290-294	microRNA 4463	Homo sapiens	18-26
28065859-7	2017	LAP, PAZ, REG and SOR inhibited UGT1A1-catalysed bilirubin glucuronidation with mean IC50 values ranging from 34nM (REG) to 3734nM (PAZ).	Bilirubin	49-58	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	32-38
28262508-9	2017	We identified down-regulated expression of Mrp2 as potential factors linked to increased serum bilirubin levels and decreased levels of glutathione in the liver and increased liver injury severity.	Bilirubin	95-104	prolactin family 2, subfamily c, member 3	Mus musculus	43-47
29152604-8	2017	These structural and functional defects are associated with cytoplasm distribution of a canalicular membrane protein MRP2 (multidrug resistant protein 2) which is responsible for clearing bilirubin.	Bilirubin	188-197	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	117-121
29152604-8	2017	These structural and functional defects are associated with cytoplasm distribution of a canalicular membrane protein MRP2 (multidrug resistant protein 2) which is responsible for clearing bilirubin.	Bilirubin	188-197	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	123-152
28365565-0	2017	Bilirubin Prevents Atherosclerotic Lesion Formation in Low-Density Lipoprotein Receptor-Deficient Mice by Inhibiting Endothelial VCAM-1 and ICAM-1 Signaling.	Bilirubin	0-9	low density lipoprotein receptor	Mus musculus	55-87
28006834-0	2017	Pretreatment direct bilirubin and total cholesterol are significant predictors of overall survival in advanced non-small-cell lung cancer patients with EGFR mutations.	Bilirubin	20-29	epidermal growth factor receptor	Homo sapiens	152-156
28006834-1	2017	This study was designed to examine the prediction of pretreatment circulating bilirubin and cholesterol for overall survival in 459 advanced non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations.	Bilirubin	78-87	epidermal growth factor receptor	Homo sapiens	224-228
28365565-0	2017	Bilirubin Prevents Atherosclerotic Lesion Formation in Low-Density Lipoprotein Receptor-Deficient Mice by Inhibiting Endothelial VCAM-1 and ICAM-1 Signaling.	Bilirubin	0-9	vascular cell adhesion molecule 1	Mus musculus	129-135
28365565-0	2017	Bilirubin Prevents Atherosclerotic Lesion Formation in Low-Density Lipoprotein Receptor-Deficient Mice by Inhibiting Endothelial VCAM-1 and ICAM-1 Signaling.	Bilirubin	0-9	intercellular adhesion molecule 1	Mus musculus	140-146
28365565-2	2017	The goals of the present investigations were to assess the ability of bilirubin to prevent atherosclerotic plaque formation in low-density lipoprotein receptor-deficient (Ldlr-/- ) mice and elucidate the molecular processes underlying this effect.	Bilirubin	70-79	low density lipoprotein receptor	Mus musculus	127-159
28365565-2	2017	The goals of the present investigations were to assess the ability of bilirubin to prevent atherosclerotic plaque formation in low-density lipoprotein receptor-deficient (Ldlr-/- ) mice and elucidate the molecular processes underlying this effect.	Bilirubin	70-79	low density lipoprotein receptor	Mus musculus	171-175
28365565-4	2017	A potent antioxidant, bilirubin effectively blocks the generation of cellular reactive oxygen species induced by the cross-linking of endothelial vascular cell adhesion molecule 1 (VCAM-1) or intercellular adhesion molecule 1 (ICAM-1).	Bilirubin	22-31	vascular cell adhesion molecule 1	Mus musculus	146-179
28365565-4	2017	A potent antioxidant, bilirubin effectively blocks the generation of cellular reactive oxygen species induced by the cross-linking of endothelial vascular cell adhesion molecule 1 (VCAM-1) or intercellular adhesion molecule 1 (ICAM-1).	Bilirubin	22-31	vascular cell adhesion molecule 1	Mus musculus	181-187
28365565-4	2017	A potent antioxidant, bilirubin effectively blocks the generation of cellular reactive oxygen species induced by the cross-linking of endothelial vascular cell adhesion molecule 1 (VCAM-1) or intercellular adhesion molecule 1 (ICAM-1).	Bilirubin	22-31	intercellular adhesion molecule 1	Mus musculus	192-225
28365565-4	2017	A potent antioxidant, bilirubin effectively blocks the generation of cellular reactive oxygen species induced by the cross-linking of endothelial vascular cell adhesion molecule 1 (VCAM-1) or intercellular adhesion molecule 1 (ICAM-1).	Bilirubin	22-31	intercellular adhesion molecule 1	Mus musculus	227-233
28365565-6	2017	When administered to Ldlr-/- mice on a Western diet, bilirubin (30 mg/kg intraperitoneally) prevents atherosclerotic plaque formation, but does not alter circulating cholesterol or chemokine levels.	Bilirubin	53-62	low density lipoprotein receptor	Mus musculus	21-25
28365565-7	2017	Aortic roots from bilirubin-treated animals exhibit reduced lipid and collagen deposition, decreased infiltration of monocytes and lymphocytes, fewer smooth muscle cells, and diminished levels of chlorotyrosine and nitrotyrosine, without changes in VCAM-1 or ICAM-1 expression.	Bilirubin	18-27	vascular cell adhesion molecule 1	Mus musculus	249-255
28365565-7	2017	Aortic roots from bilirubin-treated animals exhibit reduced lipid and collagen deposition, decreased infiltration of monocytes and lymphocytes, fewer smooth muscle cells, and diminished levels of chlorotyrosine and nitrotyrosine, without changes in VCAM-1 or ICAM-1 expression.	Bilirubin	18-27	intercellular adhesion molecule 1	Mus musculus	259-265
28365565-8	2017	CONCLUSIONS: Bilirubin suppresses atherosclerotic plaque formation in Ldlr-/- mice by disrupting endothelial VCAM-1- and ICAM-1-mediated leukocyte migration through the scavenging of reactive oxygen species signaling intermediaries.	Bilirubin	13-22	low density lipoprotein receptor	Mus musculus	70-74
28365565-8	2017	CONCLUSIONS: Bilirubin suppresses atherosclerotic plaque formation in Ldlr-/- mice by disrupting endothelial VCAM-1- and ICAM-1-mediated leukocyte migration through the scavenging of reactive oxygen species signaling intermediaries.	Bilirubin	13-22	vascular cell adhesion molecule 1	Mus musculus	109-115
28365565-8	2017	CONCLUSIONS: Bilirubin suppresses atherosclerotic plaque formation in Ldlr-/- mice by disrupting endothelial VCAM-1- and ICAM-1-mediated leukocyte migration through the scavenging of reactive oxygen species signaling intermediaries.	Bilirubin	13-22	intercellular adhesion molecule 1	Mus musculus	121-127
27977017-1	2017	OBJECTIVE: The objective of our study was to measure the effect of genetic variants of these two enzymes, UGT1A1 and SLCO1B1, in the bilirubin metabolic pathway on the degree of hyperbilirubinemia in a cohort of African-American (AA) infants from our well-baby nursery.	Bilirubin	133-142	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	106-112
27977017-1	2017	OBJECTIVE: The objective of our study was to measure the effect of genetic variants of these two enzymes, UGT1A1 and SLCO1B1, in the bilirubin metabolic pathway on the degree of hyperbilirubinemia in a cohort of African-American (AA) infants from our well-baby nursery.	Bilirubin	133-142	solute carrier organic anion transporter family member 1B1	Homo sapiens	117-124
28260031-6	2017	As the bilirubin concentration increased, HSCs demonstrated reduced production of reactive oxygen species, reduced protein expression levels of alpha-smooth muscle actin, a decreased mRNA expression ratio of tissue inhibitor of matrix metalloproteinase-1/matrix metalloproteinase-2, decreased proliferation and increased apoptosis.	Bilirubin	7-16	actin gamma 2, smooth muscle	Rattus norvegicus	144-169
28103424-8	2017	Multivariate analysis indicated that age, albumin, and bilirubin, but not IgG4, at the time of diagnosis affected PSC prognosis.	Bilirubin	55-64	PSC	Homo sapiens	114-117
28260031-6	2017	As the bilirubin concentration increased, HSCs demonstrated reduced production of reactive oxygen species, reduced protein expression levels of alpha-smooth muscle actin, a decreased mRNA expression ratio of tissue inhibitor of matrix metalloproteinase-1/matrix metalloproteinase-2, decreased proliferation and increased apoptosis.	Bilirubin	7-16	matrix metallopeptidase 2	Rattus norvegicus	208-281
28348377-6	2017	Our findings indicate that acute exposure to bilirubin increases VGCC currents, primarily by targeting P/Q-type calcium channels via Ca2+ and calmodulin dependent mechanisms to overwhelm neurons with excessive Ca2+.	Bilirubin	45-54	calmodulin 1	Rattus norvegicus	103-152
28446312-5	2017	Further gene evaluation disclosed a insertion mutation in the (TA)6TAA box, and a missense mutation(G A) at 211 bp of exon 1, corresponding to the deficiency in the bilirubin-conjugating enzyme uridine-diphosphoglucuronosyl transferase1A1 (UGT1A1).	Bilirubin	165-174	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	194-238
28446312-5	2017	Further gene evaluation disclosed a insertion mutation in the (TA)6TAA box, and a missense mutation(G A) at 211 bp of exon 1, corresponding to the deficiency in the bilirubin-conjugating enzyme uridine-diphosphoglucuronosyl transferase1A1 (UGT1A1).	Bilirubin	165-174	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	240-246
28340583-7	2017	In particular, we identified TNFalpha and NFKbeta as key mediators of bilirubin-induced inflammatory response.	Bilirubin	70-79	tumor necrosis factor	Mus musculus	29-37
28287189-5	2017	The photoactivity was maximized in the 4 wt.% g-C3N4-coated P25, as the bilirubin removal rate under green light irradiation was more than 5-fold higher than that under the clinically-used blue light without any photocatalyst.	Bilirubin	72-81	tubulin polymerization promoting protein	Homo sapiens	60-63
28507926-9	2017	On multivariate analysis, platelet count, AST and total bilirubin at baseline were significantly correlated to AFP reduction (p = 0.04, 0.009 and 0.04, respectively).	Bilirubin	56-65	alpha fetoprotein	Homo sapiens	111-114
28287189-0	2017	Efficient Photocatalytic Bilirubin Removal over the Biocompatible Core/Shell P25/g-C3N4 Heterojunctions with Metal-free Exposed Surfaces under Moderate Green Light Irradiation.	Bilirubin	25-34	tubulin polymerization promoting protein	Homo sapiens	77-80
28442109-4	2017	RESULTS: Obtained results revealed that administration of CCl4 caused a significant increase in plasma ASAT, ALAT, ALP and LDH activities and total bilirubin concentration, compared to the control group.	Bilirubin	148-157	C-C motif chemokine ligand 4	Rattus norvegicus	58-62
28263100-9	2017	In AIH, DNAse1-activity was positively correlated with aspartate aminotransferase (AST) (p &lt; 0.02), bilirubin (p &lt; 0.01) and increased IgG (&gt;1400 mg/dl; p &lt; 0.05); in PBC, with AST (p &lt; 0.01), alanine aminotransferase (ALT) (p &lt; 0.03) and anti-mitochondrial antibodies (AMA) (p = 0.008).	Bilirubin	103-112	deoxyribonuclease 1	Homo sapiens	8-14
27471884-5	2017	DS also mitigated CCl4-induced elevation of classical liver function markers (alanine aminotransferase, aspartate aminotransferase, and bilirubin) at certain time points, depending on specific liver function markers.	Bilirubin	136-145	C-C motif chemokine ligand 4	Rattus norvegicus	18-22
28338110-3	2017	The UGT1A1 promoter (TA) repeats variants are documented of being involved in abnormally elevated bilirubin levels.	Bilirubin	98-107	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	4-10
28263463-7	2017	The data show that this drug inhibits the enzyme UDP-glucuronosyl transferase-1A1, responsible for conjugating bilirubin with glucuronic acid.	Bilirubin	111-120	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	49-81
28338110-4	2017	The aim of the present study is to analyze the impact of UGT1A1 promoter variants on bilirubin levels in Romanian patients clinically supected with GS.	Bilirubin	85-94	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	57-63
28296739-11	2017	Total bilirubin increase was noticed according to thymine-adenine repeats in genotypes (P &lt; 0.001), and the TB greater than 1 mg/dL group had more UGT1A1*28 subjects than in the group with TB values &lt;1 mg/dL (18.3 vs 5.3; P &lt; 0.001).	Bilirubin	111-113	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	150-156
27929530-6	2017	Infants randomized to DCC compared with ICC had significantly less RPBV (20.0 versus 30.8 ml kg-1, P&lt;0.001), higher hemoglobin levels (19.4 versus 17.8 g dl-1, P=0.002) at 24 to 48 h, with no difference in bilirubin levels.	Bilirubin	209-218	DCC netrin 1 receptor	Homo sapiens	22-25
28296739-0	2017	UGT1A1*28 relationship with abnormal total bilirubin levels in chronic hepatitis C patients: Outcomes from a case-control study.	Bilirubin	43-52	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
28296739-13	2017	Among patients with increased TB levels, the frequency of UGT1A1*28 is higher than those with normal TB.	Bilirubin	30-32	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	58-64
28296739-4	2017	Our aim was to assess UGT1A1 genotypes" frequency in chronic hepatitis C (CHC) patients and correlate with total bilirubin (TB).	Bilirubin	113-122	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	22-28
28296739-13	2017	Among patients with increased TB levels, the frequency of UGT1A1*28 is higher than those with normal TB.	Bilirubin	101-103	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	58-64
28296739-4	2017	Our aim was to assess UGT1A1 genotypes" frequency in chronic hepatitis C (CHC) patients and correlate with total bilirubin (TB).	Bilirubin	124-126	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	22-28
28225832-9	2017	In addition, bilirubin treatment decreased fibronectin expression in tubular epithelial cells in a dose-dependent manner (P &lt; 0.05).	Bilirubin	13-22	fibronectin 1	Mus musculus	43-54
28627343-11	2017	The HO-1 activity was also measured by the generation of bilirubin with the method of double-wave spectrophotometry.	Bilirubin	57-66	heme oxygenase 1	Rattus norvegicus	4-8
28088947-1	2017	Heme oxygenase (HO-1) catalyzes heme to carbon monoxide (CO), biliverdin/bilirubin, and iron and is known to prevent the pathogenesis of several human diseases.	Bilirubin	73-82	heme oxygenase 1	Homo sapiens	16-20
28167773-1	2017	Severe neonatal hyperbilirubinemia (SNH) and the onset of bilirubin encephalopathy and kernicterus result in part from delayed expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) and the inability to metabolize bilirubin.	Bilirubin	21-30	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	141-172
28167773-1	2017	Severe neonatal hyperbilirubinemia (SNH) and the onset of bilirubin encephalopathy and kernicterus result in part from delayed expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) and the inability to metabolize bilirubin.	Bilirubin	58-67	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	141-172
28167773-8	2017	Physiological events during neonatal development that target activation of an IKKbeta/NCoR1 loop in intestinal epithelial cells lead to derepression of genes involved in intestinal maturation and bilirubin detoxification.	Bilirubin	196-205	inhibitor of kappaB kinase beta	Mus musculus	78-85
28167773-8	2017	Physiological events during neonatal development that target activation of an IKKbeta/NCoR1 loop in intestinal epithelial cells lead to derepression of genes involved in intestinal maturation and bilirubin detoxification.	Bilirubin	196-205	nuclear receptor co-repressor 1	Mus musculus	86-91
28088947-3	2017	Treatment of RAW264.7 cells with CORM-2 (a CO donor) and bilirubin, but not with iron, decreased RANKL-induced osteoclastogenesis, with CORM-2 having a more potent anti-osteogenic effect.	Bilirubin	57-66	TNF superfamily member 11	Homo sapiens	97-102
26929000-2	2017	Intraperitoneal injection of male Wistar rats with CCl4 1 mL kg-1 , 1:1 mixture with corn oil for 3 days increased serum alanine transaminase, aspartate transaminase, and alkaline phosphatase activities as well as total bilirubin, triglycerides and total cholesterol levels.	Bilirubin	220-229	C-C motif chemokine ligand 4	Rattus norvegicus	51-55
27565173-3	2017	Having ruled out changes in bilirubin metabolism, we demonstrated a 2- to 3-fold increase in serum ceruloplasmin levels, likely accounting for the observed green color.	Bilirubin	28-37	ceruloplasmin	Rattus norvegicus	99-112
27686368-6	2017	CART analysis identified four variables as prognostic factors of ACHBLF: total bilirubin, age, serum sodium and INR, and three distinct risk groups: low risk (4.2%), intermediate risk (30.2%-53.2%) and high risk (81.4%-96.9%).	Bilirubin	79-88	CART prepropeptide	Homo sapiens	0-4
28639200-10	2017	In preclinical models of liver disease, treatment with C/EBPalpha saRNA has shown reduction in tumor volume and improvement in serum markers of essential liver function such as albumin, bilirubin, aspartate aminotransferase (AST), and alanine transaminase (ALT).	Bilirubin	186-195	CCAAT enhancer binding protein alpha	Homo sapiens	55-65
28161963-7	2017	On the other hand, addition of a CO-donor or bilirubin decreased the p24 expression.	Bilirubin	45-54	transmembrane p24 trafficking protein 2	Homo sapiens	69-72
28952244-2	2017	Therefore, changes in UGT1A1 expression/functional can not only cause adverse clinical drug/herbs-drug interactions, but also lead to metabolic disorder of endogenous substances, causing high blood bilirubin, bilirubin encephalopathy and liver injury, as well as other side effects.	Bilirubin	198-207	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	22-28
28952244-2	2017	Therefore, changes in UGT1A1 expression/functional can not only cause adverse clinical drug/herbs-drug interactions, but also lead to metabolic disorder of endogenous substances, causing high blood bilirubin, bilirubin encephalopathy and liver injury, as well as other side effects.	Bilirubin	209-218	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	22-28
27393133-6	2017	Bilirubin supplementation of islet media also decreased the release of DAMPs (HMGB1), inflammatory cytokines (IL-1beta and IL-6), and chemokines (MCP-1).	Bilirubin	0-9	high mobility group box 1	Mus musculus	78-83
27393133-6	2017	Bilirubin supplementation of islet media also decreased the release of DAMPs (HMGB1), inflammatory cytokines (IL-1beta and IL-6), and chemokines (MCP-1).	Bilirubin	0-9	interleukin 1 beta	Mus musculus	110-118
27393133-6	2017	Bilirubin supplementation of islet media also decreased the release of DAMPs (HMGB1), inflammatory cytokines (IL-1beta and IL-6), and chemokines (MCP-1).	Bilirubin	0-9	interleukin 6	Mus musculus	123-127
27393133-6	2017	Bilirubin supplementation of islet media also decreased the release of DAMPs (HMGB1), inflammatory cytokines (IL-1beta and IL-6), and chemokines (MCP-1).	Bilirubin	0-9	mast cell protease 1	Mus musculus	146-151
27393133-8	2017	Treatment of macrophages with bilirubin induced a regulatory phenotype, with increased expression of PD-L1.	Bilirubin	30-39	CD274 antigen	Mus musculus	101-106
28399191-10	2017	The UGT1A1*28 polymorphism was detected more often among neonates with elevated bilirubin.	Bilirubin	80-89	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	4-10
27943244-1	2017	OBJECTIVE: The present study was undertaken to investigate the genotype and allele frequencies of the variants in the four bilirubin metabolism genes (UGT1A1, OATP2, HMOX1, and BLVRA) and their association with hyperbilirubinemia.	Bilirubin	123-132	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	151-157
27890454-6	2017	RESULTS: The study showed a significant difference in CD19+ lymphocytes percentage between patients before phototherapy and controls (P value&lt;0.01), also a significant correlation between serum levels of total bilirubin in patients and CD19+ lymphocytes percentage (P value&lt;0.05).	Bilirubin	213-222	CD19 molecule	Homo sapiens	54-58
27890454-6	2017	RESULTS: The study showed a significant difference in CD19+ lymphocytes percentage between patients before phototherapy and controls (P value&lt;0.01), also a significant correlation between serum levels of total bilirubin in patients and CD19+ lymphocytes percentage (P value&lt;0.05).	Bilirubin	213-222	CD19 molecule	Homo sapiens	239-243
27943244-1	2017	OBJECTIVE: The present study was undertaken to investigate the genotype and allele frequencies of the variants in the four bilirubin metabolism genes (UGT1A1, OATP2, HMOX1, and BLVRA) and their association with hyperbilirubinemia.	Bilirubin	123-132	solute carrier organic anion transporter family member 1B1	Homo sapiens	159-164
27943244-1	2017	OBJECTIVE: The present study was undertaken to investigate the genotype and allele frequencies of the variants in the four bilirubin metabolism genes (UGT1A1, OATP2, HMOX1, and BLVRA) and their association with hyperbilirubinemia.	Bilirubin	123-132	heme oxygenase 1	Homo sapiens	166-171
27943244-1	2017	OBJECTIVE: The present study was undertaken to investigate the genotype and allele frequencies of the variants in the four bilirubin metabolism genes (UGT1A1, OATP2, HMOX1, and BLVRA) and their association with hyperbilirubinemia.	Bilirubin	123-132	biliverdin reductase A	Homo sapiens	177-182
28412905-3	2017	The enzyme HO-1 catalyzes the degradation of heme into three biologically active end products, namely biliverdin/bilirubin, CO and ferrous ion.	Bilirubin	113-122	heme oxygenase 1	Homo sapiens	11-15
27750089-4	2017	Besides, the large planar pi-configuration structure of 3D-pGR made it possible to compete effectively with albumin for bilirubin binding.	Bilirubin	120-129	progesterone receptor	Homo sapiens	59-62
27750089-5	2017	Taking advantages of these fantastic characteristics, the 3D-pGR was demonstrated to be extraordinarily efficient for bilirubin removal from a bovine serum albumin (BSA)-rich solution.	Bilirubin	118-127	progesterone receptor	Homo sapiens	61-64
27750089-5	2017	Taking advantages of these fantastic characteristics, the 3D-pGR was demonstrated to be extraordinarily efficient for bilirubin removal from a bovine serum albumin (BSA)-rich solution.	Bilirubin	118-127	albumin	Homo sapiens	150-163
27750089-6	2017	Under optimized conditions, the maximum adsorption capacity of 3D-pGR for BSA-bonded bilirubin was up to 126.1mgg-1, which is not only significantly higher than the adsorption capacities of currently available adsorbents towards albumin-bonded bilirubin, but also superior to those of many reported adsorbents towards free bilirubin.	Bilirubin	85-94	progesterone receptor	Homo sapiens	66-69
27750089-6	2017	Under optimized conditions, the maximum adsorption capacity of 3D-pGR for BSA-bonded bilirubin was up to 126.1mgg-1, which is not only significantly higher than the adsorption capacities of currently available adsorbents towards albumin-bonded bilirubin, but also superior to those of many reported adsorbents towards free bilirubin.	Bilirubin	244-253	progesterone receptor	Homo sapiens	66-69
27750089-6	2017	Under optimized conditions, the maximum adsorption capacity of 3D-pGR for BSA-bonded bilirubin was up to 126.1mgg-1, which is not only significantly higher than the adsorption capacities of currently available adsorbents towards albumin-bonded bilirubin, but also superior to those of many reported adsorbents towards free bilirubin.	Bilirubin	244-253	progesterone receptor	Homo sapiens	66-69
27760386-1	2017	Heme oxygenase 1 (HMOX1) degrades heme into biliverdin, which is subsequently converted to bilirubin by biliverdin reductase (BVRa or BVRb) in a manner analogous to the classic anti-oxidant glutathione-recycling pathway.	Bilirubin	91-100	heme oxygenase 1a	Danio rerio	0-16
27760386-1	2017	Heme oxygenase 1 (HMOX1) degrades heme into biliverdin, which is subsequently converted to bilirubin by biliverdin reductase (BVRa or BVRb) in a manner analogous to the classic anti-oxidant glutathione-recycling pathway.	Bilirubin	91-100	heme oxygenase 1a	Danio rerio	18-23
27908259-1	2017	BACKGROUND: Bilirubin is a toxic waste product of metabolism, eliminated mainly through UGT1A1 mediated conjugation to mono- and di-glucuronides.	Bilirubin	12-21	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	88-94
27780834-4	2017	Transcript levels of CAR target genes were significantly increased in HepaRG-CAR cultures without DMSO, resulting in increased activities of cytochrome P450 (P450) enzymes and bilirubin conjugation to levels equal or surpassing those of HepaRG cells cultured with DMSO.	Bilirubin	176-185	nuclear receptor subfamily 1 group I member 3	Homo sapiens	21-24
27780834-4	2017	Transcript levels of CAR target genes were significantly increased in HepaRG-CAR cultures without DMSO, resulting in increased activities of cytochrome P450 (P450) enzymes and bilirubin conjugation to levels equal or surpassing those of HepaRG cells cultured with DMSO.	Bilirubin	176-185	nuclear receptor subfamily 1 group I member 3	Homo sapiens	77-80
27908259-8	2017	The Km and Vmax values for total bilirubin glucuronide formations were determined to be 0.05 +- 0.01 muM and 181.9 +- 5.3 pmol/min/mg-protein, respectively, in human recombinant UGT1A1, and 0.23 +- 0.05 muM and 875 +- 45 pmol/min/mg protein in human liver microsomes (HLM).	Bilirubin	33-42	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	178-184
27908259-10	2017	This method was successfully utilized to determine bilirubin glucuronidation kinetics in HLM and human rUGT1A1.	Bilirubin	51-60	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	103-110
27908781-6	2017	Moreover, a secondary metabolite of BV, bilirubin (BR), specifically mediates this anti-PRRSV activity via a nitric oxide (NO)-dependent cGMP/PKG signaling pathway.	Bilirubin	40-49	protein kinase cGMP-dependent 1	Homo sapiens	142-145
27908781-6	2017	Moreover, a secondary metabolite of BV, bilirubin (BR), specifically mediates this anti-PRRSV activity via a nitric oxide (NO)-dependent cGMP/PKG signaling pathway.	Bilirubin	51-53	protein kinase cGMP-dependent 1	Homo sapiens	142-145
27789152-12	2017	CONCLUSIONS: Results of present study demonstrated that AST, GGT, and BILI, particularly AST, had a potential to eliminate SCE from stroke subtypes, and the ability of eliminating SCE would be strengthened after combining each liver function indicator together.	Bilirubin	70-74	solute carrier family 17 member 5	Homo sapiens	89-92
27867098-9	2017	However, silencing HO-1 expression abrogated the protective action of ammonia and this was reversed by the administration of carbon monoxide but not bilirubin or iron.	Bilirubin	149-158	heme oxygenase 1	Mus musculus	19-23
28025333-0	2017	Modulation of bilirubin neurotoxicity by the Abcb1 transporter in the Ugt1-/- lethal mouse model of neonatal hyperbilirubinemia.	Bilirubin	14-23	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	45-50
28025333-5	2017	The Abcb1 and Abcc1 members of the ABC family of transporters have been suggested to have an active role in exporting unconjugated bilirubin from the central nervous system into plasma.	Bilirubin	131-140	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	4-9
28025333-5	2017	The Abcb1 and Abcc1 members of the ABC family of transporters have been suggested to have an active role in exporting unconjugated bilirubin from the central nervous system into plasma.	Bilirubin	131-140	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	14-19
28025333-8	2017	Interestingly, Abcc1 role appeared to be less important.In the cerebellum of Ugt1-/- mice, hyperbilirubinemia induced the expression of Car and Pxr nuclear receptors, known regulators of genes involved in the genotoxic response.We demonstrated a critical role of Abcb1 in protecting the cerebellum from bilirubin toxicity during neonatal development, the most clinically relevant phase for human babies, providing further understanding of the mechanisms regulating bilirubin neurotoxicity in vivo.	Bilirubin	96-105	UDP glucuronosyltransferase 1 family, polypeptide A2	Mus musculus	77-81
28025333-8	2017	Interestingly, Abcc1 role appeared to be less important.In the cerebellum of Ugt1-/- mice, hyperbilirubinemia induced the expression of Car and Pxr nuclear receptors, known regulators of genes involved in the genotoxic response.We demonstrated a critical role of Abcb1 in protecting the cerebellum from bilirubin toxicity during neonatal development, the most clinically relevant phase for human babies, providing further understanding of the mechanisms regulating bilirubin neurotoxicity in vivo.	Bilirubin	96-105	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	263-268
28025333-8	2017	Interestingly, Abcc1 role appeared to be less important.In the cerebellum of Ugt1-/- mice, hyperbilirubinemia induced the expression of Car and Pxr nuclear receptors, known regulators of genes involved in the genotoxic response.We demonstrated a critical role of Abcb1 in protecting the cerebellum from bilirubin toxicity during neonatal development, the most clinically relevant phase for human babies, providing further understanding of the mechanisms regulating bilirubin neurotoxicity in vivo.	Bilirubin	303-312	UDP glucuronosyltransferase 1 family, polypeptide A2	Mus musculus	77-81
27704169-1	2017	PURPOSE: Complete or partial inactivity of UGT1A1, the unique enzyme responsible for bilirubin glucuronidation, is commonly associated with hyperbilirubinemia.	Bilirubin	85-94	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	43-49
27662781-6	2017	TBiL level was negatively correlated with age, weight, SBP, TC, FBG, 2hPG, diabetic duration and positively correlated with HDL-C.	Bilirubin	0-4	selenium binding protein 1	Homo sapiens	55-58
27967321-0	2017	The impact of the UGT1A1*60 allele on bilirubin serum concentrations.	Bilirubin	38-47	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	18-24
28951772-0	2017	Serum Bilirubin Levels and Promoter Variations in HMOX1 and UGT1A1 Genes in Patients with Fabry Disease.	Bilirubin	6-15	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	60-66
28951772-7	2017	However, the presence of the TA7 allele UGT1A1 gene promoter, responsible for higher systemic bilirubin levels, was associated with a twofold lower risk of manifestation of FD (OR = 0.51, 95% CI = 0.27-0.97, p = 0.038).	Bilirubin	94-103	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	40-46
27967321-2	2017	MATERIALS &amp; METHODS: Retrospective review of clinically obtained serum bilirubin concentrations in pediatric patients to evaluate the association of the UGT1A1 -3279T&gt;G (*60) variant with bilirubin concentrations and assessed linkage disequilibrium of the UGT1A1 -3279T&gt;G (*60) and A(TA)7TAA (*28) variants.	Bilirubin	195-204	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	157-163
27967321-4	2017	Total bilirubin concentration was lower in patients homozygous for the UGT1A1 -3279T&gt;G (*60/*60) variant than in patients homozygous for the UGT1A1 A(TA)7TAA (*28/*28) variant (p &lt; 0.01).	Bilirubin	6-15	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	71-77
27967321-4	2017	Total bilirubin concentration was lower in patients homozygous for the UGT1A1 -3279T&gt;G (*60/*60) variant than in patients homozygous for the UGT1A1 A(TA)7TAA (*28/*28) variant (p &lt; 0.01).	Bilirubin	6-15	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	144-150
28933122-0	2016	[Hepatotoxicity of emodin based on UGT1A1 enzyme-mediated bilirubin in liver microsomes].	Bilirubin	58-67	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	35-41
28083086-11	2016	AST showed the sharpest decline followed by bilirubin and ALT.	Bilirubin	44-53	solute carrier family 17 member 5	Homo sapiens	0-3
27942586-5	2016	Furthermore, IRF5 expression positively correlated with clinical markers of liver damage, such as plasma transaminase and bilirubin levels.	Bilirubin	122-131	interferon regulatory factor 5	Homo sapiens	13-17
26866975-12	2016	Mean serum total bilirubin was 17.2 +- 4.4 in G6PD deficient cases.	Bilirubin	17-26	glucose-6-phosphate dehydrogenase	Homo sapiens	46-50
27994859-6	2016	This observation suggests that dRTA may be an early manifestation of bilirubin-associated nephropathy or the consequence of an immune mechanism.	Bilirubin	69-78	rta	Drosophila melanogaster	31-35
28933122-1	2016	To study the hepatotoxicity of emodin based on bilirubin metabolism mediated by glucuronidation of UGT1A1 enzyme.	Bilirubin	47-56	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	99-105
27932985-2	2016	Nowadays it is clear that PXR is also involved in regulation of intermediate metabolism through trans-activation and trans-repression of genes controlling glucose, lipid, cholesterol, bile acid, and bilirubin homeostasis.	Bilirubin	199-208	nuclear receptor subfamily 1 group I member 2	Homo sapiens	26-29
27671773-2	2016	Heme oxygenase enzymes (HMOX1 and HMOX2) degrade heme into biliverdin and carbon monoxide, with biliverdin subsequently being converted to bilirubin by biliverdin reductase (BVRa or BVRb).	Bilirubin	139-148	heme oxygenase 1a	Danio rerio	24-29
27738106-2	2016	Biliverdin reductase A (BVRA) is a multifunctioning protein primarily responsible for the reduction of biliverdin to bilirubin.	Bilirubin	117-126	biliverdin reductase A	Mus musculus	0-22
27738106-2	2016	Biliverdin reductase A (BVRA) is a multifunctioning protein primarily responsible for the reduction of biliverdin to bilirubin.	Bilirubin	117-126	biliverdin reductase A	Mus musculus	24-28
27411481-8	2016	RESULTS: SSc patients have lower plasma levels of bilirubin, suggestive of an aberrant HO-1 function.	Bilirubin	50-59	heme oxygenase 1	Homo sapiens	87-91
26996761-0	2016	Serum Bilirubin and Their Association With C-Reactive Protein in Patients With Migraine.	Bilirubin	6-15	C-reactive protein	Homo sapiens	43-61
26996761-2	2016	An inverse relationship between serum bilirubin and CRP has been observed in various diseases.	Bilirubin	38-47	C-reactive protein	Homo sapiens	52-55
27662012-0	2016	Mutating heme oxygenase-1 into a peroxidase causes a defect in bilirubin synthesis associated with microcytic anemia and severe hyperinflammation.	Bilirubin	63-72	heme oxygenase 1	Homo sapiens	9-25
27580512-13	2016	In addition, hepatic COX2 mRNA expression was positively correlated with AST, ALK-P, total bilirubin, and 6-keto-PGF1alpha (all p &lt; 0.05), but not correlated with total movements.	Bilirubin	91-100	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	21-25
27447803-12	2016	One patient developed a non-classic RILD with a fivefold increase in transaminase enzymes level and a shift in Child-Pugh category from B7 to C10 due to bilirubin increase.	Bilirubin	153-162	homeobox C10	Homo sapiens	142-145
27634895-7	2016	In CHB patients, A20 mRNA was closely associated with alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin.	Bilirubin	129-138	immunoglobulin kappa variable 1-27	Homo sapiens	17-20
27776508-13	2016	In CCl4 treated rats the level of alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin was significantly increased while the albumin concentration in serum was decreased as compared to control group.	Bilirubin	98-107	C-C motif chemokine ligand 4	Rattus norvegicus	3-7
27639646-5	2016	Among the HO byproducts, combined CORM-2 and bilirubin treatment effectively increased PGC-1alpha, Cyt c and COX2 expression, mitochondrial biogenesis, and ATP synthesis, and these increases were blocked by Ca2+ chelators.	Bilirubin	45-54	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	87-97
27639646-5	2016	Among the HO byproducts, combined CORM-2 and bilirubin treatment effectively increased PGC-1alpha, Cyt c and COX2 expression, mitochondrial biogenesis, and ATP synthesis, and these increases were blocked by Ca2+ chelators.	Bilirubin	45-54	cytochrome c oxidase II, mitochondrial	Mus musculus	109-113
27316791-11	2016	In addition, hBVR regulated EMT through the ERK1/2 signaling, but bilirubin, which is a product of hBVR in the heme metabolism pathway in breast cancer, did not.	Bilirubin	66-75	biliverdin reductase A	Homo sapiens	99-103
27734897-0	2016	Lysozyme and bilirubin bind to ACE and regulate its conformation and shedding.	Bilirubin	13-22	angiotensin I converting enzyme	Homo sapiens	31-34
27734897-6	2016	We identified the ACE-binding protein in the blood as lysozyme and also a Low Molecular Weight (LMW) ACE effector, bilirubin, which act in concert to regulate ACE conformation and thereby influence ACE shedding.	Bilirubin	115-124	angiotensin I converting enzyme	Homo sapiens	18-21
27734897-6	2016	We identified the ACE-binding protein in the blood as lysozyme and also a Low Molecular Weight (LMW) ACE effector, bilirubin, which act in concert to regulate ACE conformation and thereby influence ACE shedding.	Bilirubin	115-124	angiotensin I converting enzyme	Homo sapiens	101-104
27734897-6	2016	We identified the ACE-binding protein in the blood as lysozyme and also a Low Molecular Weight (LMW) ACE effector, bilirubin, which act in concert to regulate ACE conformation and thereby influence ACE shedding.	Bilirubin	115-124	angiotensin I converting enzyme	Homo sapiens	101-104
27734897-6	2016	We identified the ACE-binding protein in the blood as lysozyme and also a Low Molecular Weight (LMW) ACE effector, bilirubin, which act in concert to regulate ACE conformation and thereby influence ACE shedding.	Bilirubin	115-124	angiotensin I converting enzyme	Homo sapiens	101-104
27676153-12	2016	Instead, it is possible that elevation in the level of bilirubin conjugates in blood is mediated through inhibition of hepatic OATPs, which are responsible for their reuptake and/or downregulation of MRP2 transporter as a consequence of cholestatic injury.	Bilirubin	55-64	ATP binding cassette subfamily C member 2	Homo sapiens	200-204
27510297-7	2016	Negative, weak or mild expression of TGR5 was correlated with younger age, higher plasma level of total/direct bilirubin, higher plasma concentration of CA-125, advanced tumor stage and advanced AJCC TNM stage.	Bilirubin	111-120	G protein-coupled bile acid receptor 1	Homo sapiens	37-41
26935006-2	2016	Atazanavir (ATV) inhibits UDP-glucuronosyl-transferase 1A1 (UGT1A1), thus increasing unconjugated bilirubin levels.	Bilirubin	98-107	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	26-58
26935006-2	2016	Atazanavir (ATV) inhibits UDP-glucuronosyl-transferase 1A1 (UGT1A1), thus increasing unconjugated bilirubin levels.	Bilirubin	98-107	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	60-66
27692168-0	2016	Does bilirubin prevent hepatic steatosis through activation of the PPARalpha nuclear receptor?	Bilirubin	5-14	peroxisome proliferator activated receptor alpha	Homo sapiens	67-76
27692168-4	2016	We have recently described a novel function of bilirubin as a ligand for the peroxisome proliferator-activated receptor-alpha (PPARalpha), which we show specifically binds to the nuclear receptor.	Bilirubin	47-56	peroxisome proliferator activated receptor alpha	Homo sapiens	77-125
27692168-4	2016	We have recently described a novel function of bilirubin as a ligand for the peroxisome proliferator-activated receptor-alpha (PPARalpha), which we show specifically binds to the nuclear receptor.	Bilirubin	47-56	peroxisome proliferator activated receptor alpha	Homo sapiens	127-136
27692168-5	2016	Bilirubin may function as a selective PPAR modulator (SPPARM) to control lipid accumulation and blood glucose.	Bilirubin	0-9	peroxisome proliferator activated receptor alpha	Homo sapiens	38-42
27692168-6	2016	However, it is not known to what degree bilirubin activation of PPARalpha is responsible for the protection afforded to reduce hepatic steatosis.	Bilirubin	40-49	peroxisome proliferator activated receptor alpha	Homo sapiens	64-73
27692168-7	2016	We hypothesize that bilirubin, acting as a novel SPPARM, increases hepatic fatty acid metabolism through a PPARalpha-dependent mechanism which reduces hepatic lipid accumulation and protects against hepatic steatosis and non-alcoholic fatty liver disease (NAFLD).	Bilirubin	20-29	peroxisome proliferator activated receptor alpha	Homo sapiens	107-116
27895355-6	2016	The calculated ASGPR level was derived as: 80.695 + 0.002 x cholinesterases (CHE) (IU/L) - 0.620 x indocyanine green retention rate at 15 min (ICGR15)(%) - 0.655 x total bilirubin (TB) (umol/L).	Bilirubin	170-179	asialoglycoprotein receptor 1	Homo sapiens	15-20
27895355-6	2016	The calculated ASGPR level was derived as: 80.695 + 0.002 x cholinesterases (CHE) (IU/L) - 0.620 x indocyanine green retention rate at 15 min (ICGR15)(%) - 0.655 x total bilirubin (TB) (umol/L).	Bilirubin	181-183	asialoglycoprotein receptor 1	Homo sapiens	15-20
26385576-3	2016	Heme oxygenase isoform 1 (HO-1) is crucial for the response to oxidative stress via the catabolism of heme to carbon monoxide, bilirubin, and iron.	Bilirubin	127-136	heme oxygenase 1	Mus musculus	0-24
26385576-3	2016	Heme oxygenase isoform 1 (HO-1) is crucial for the response to oxidative stress via the catabolism of heme to carbon monoxide, bilirubin, and iron.	Bilirubin	127-136	heme oxygenase 1	Mus musculus	26-30
26850359-12	2016	In patients with ACHBLF, significantly higher prothrombin activity, lower total bilirubin and MELD score were found in TACE methylated group than unmethylated group (P&lt;0.05).	Bilirubin	80-89	ADAM metallopeptidase domain 17	Homo sapiens	119-123
27604527-1	2016	Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of which is subsequently converted to bilirubin.	Bilirubin	205-214	heme oxygenase 1	Homo sapiens	46-51
27604527-1	2016	Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of which is subsequently converted to bilirubin.	Bilirubin	205-214	heme oxygenase 2	Homo sapiens	56-61
27605390-3	2016	Distinct characteristics of NGAL and L-FABP were revealed using principal component analysis: NGAL showed linear correlations with inflammatory markers (white blood cell count and C-reactive protein), whereas L-FABP showed linear correlations with hypoperfusion and hepatic injury markers (lactate, liver transaminases and bilirubin).	Bilirubin	323-332	lipocalin 2	Homo sapiens	28-32
27493112-7	2016	RESULTS: Serum levels of alanine aminotransferase (ALT), aspartate transaminase (AST), and total bilirubin level (TBIL) in the CTLA4Ig-IDO group were lower than those in the other three groups at 14 days post-transplantation (P &lt; 0.05); mRNA and protein expressions of IL-2 and IFN-gamma were higher in the control group, but lower in the CTLA4Ig-IDO group (P &lt; 0.05).	Bilirubin	97-106	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	135-138
27269180-9	2016	In the correlation analysis, IFN-gamma was closely related to the concentration of alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, lactate dehydrase (LDH), triglyceride and fibrinogen, while IL-10 was associated with platelet count.	Bilirubin	149-158	interferon gamma	Homo sapiens	29-38
27269180-10	2016	When split the patients into two groups according to the cytokine levels, patients with high IFN-gamma presented higher level of ALT, AST, bilirubin, LDH, triglyceride, and fibrinogen, while patients with high IL-10 presented much lower hemoglobin and platelet count.	Bilirubin	139-148	interferon gamma	Homo sapiens	93-102
27288631-5	2016	LCN2 negatively correlated with bilirubin in both cohorts.	Bilirubin	32-41	lipocalin 2	Homo sapiens	0-4
27180978-0	2016	Unconjugated bilirubin elevation impairs the function and expression of breast cancer resistance protein (BCRP) at the blood-brain barrier in bile duct-ligated rats.	Bilirubin	13-22	BCR pseudogene 1	Homo sapiens	106-110
27061381-8	2016	Meanwhile, the serum CRP was negatively correlated with serum TB levels but positively correlated with peripheral WBC and the Psoriasis Area and Severity Index (PASI).	Bilirubin	62-64	C-reactive protein	Homo sapiens	21-24
27746618-10	2016	The mutant, but not wild type or heterozygous genotype of SNPs (rs6742078 and rs887829) in UGT1A1 gene, was associated with significantly higher levels of bilirubin.	Bilirubin	155-164	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	91-97
27746618-11	2016	CONCLUSIONS: Higher incidence of pigment stones in South Indians could be due to raised serum bilirubin levels that may be ascribed to variant in the UGT1A1 gene involved in glucuronidation of free bilirubin.	Bilirubin	94-103	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	150-156
27746618-11	2016	CONCLUSIONS: Higher incidence of pigment stones in South Indians could be due to raised serum bilirubin levels that may be ascribed to variant in the UGT1A1 gene involved in glucuronidation of free bilirubin.	Bilirubin	198-207	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	150-156
27484966-6	2016	The studies on the effects of picoplatin on the binding of HSA with bilirubin and heme showed that picoplatin binding caused a change of angle between two chromophores of bound bilirubin and the binding site of picoplatin does not locate in subdomain IB in HSA that bound with heme.	Bilirubin	68-77	albumin	Homo sapiens	59-62
27484966-6	2016	The studies on the effects of picoplatin on the binding of HSA with bilirubin and heme showed that picoplatin binding caused a change of angle between two chromophores of bound bilirubin and the binding site of picoplatin does not locate in subdomain IB in HSA that bound with heme.	Bilirubin	68-77	albumin	Homo sapiens	257-260
27484966-6	2016	The studies on the effects of picoplatin on the binding of HSA with bilirubin and heme showed that picoplatin binding caused a change of angle between two chromophores of bound bilirubin and the binding site of picoplatin does not locate in subdomain IB in HSA that bound with heme.	Bilirubin	177-186	albumin	Homo sapiens	59-62
27484966-6	2016	The studies on the effects of picoplatin on the binding of HSA with bilirubin and heme showed that picoplatin binding caused a change of angle between two chromophores of bound bilirubin and the binding site of picoplatin does not locate in subdomain IB in HSA that bound with heme.	Bilirubin	177-186	albumin	Homo sapiens	257-260
27387768-2	2016	Antioxidant defense is accepted to include biotransformation of biliverdin (BV) into bilirubin (BR) through BV reductase alpha (BVRalpha).	Bilirubin	85-94	biliverdin reductase A	Homo sapiens	128-136
26926206-6	2016	In ATP11C-deficient mice, plasma total bilirubin levels were 6-fold increased, compared to control, of which ~65% was conjugated and ~35% unconjugated.	Bilirubin	39-48	ATPase, class VI, type 11C	Mus musculus	3-9
27471465-8	2016	CCl4 administration induced hepatic damage in rats resulted in increased levels of aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, thiobarbituric acid reacting substances, albumin, bilirubin, TNF-alpha, IL-1beta and decreased levels of total protein and antioxidant enzymes like superoxide dismutase, catalase, and glutathione reductase.	Bilirubin	224-233	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
27166089-2	2016	Human BVR (hBVR) also reduces the hemeoxygenase activity product biliverdin to bilirubin and is directly activated by insulin receptor kinase (IRK).	Bilirubin	79-88	biliverdin reductase A	Homo sapiens	6-9
27166089-2	2016	Human BVR (hBVR) also reduces the hemeoxygenase activity product biliverdin to bilirubin and is directly activated by insulin receptor kinase (IRK).	Bilirubin	79-88	biliverdin reductase A	Homo sapiens	11-15
27316684-3	2016	We therefore investigated the role of heme oxygenase-1 (HO-1), which catalyzes the degradation of heme into the bilirubin precursor biliverdin, ferrous iron, and CO during B. pseudomallei infection.	Bilirubin	112-121	heme oxygenase 1	Mus musculus	56-60
27057738-2	2016	We evaluated the role of variations in the bilirubin uridine-5-diphosphate (UDP)-glucuronosyltransferase gene (UGT1A1) in unconjugated hyperbilirubinemia development during chemotherapy in pediatric patients with leukemia.	Bilirubin	43-52	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	111-117
27057738-3	2016	METHODS: UGT1A1 allelic variations were evaluated in 25 Japanese pediatric leukemia patients with hyperbilirubinemia (peak serum bilirubin concentration 3.57 +- 1.02 mg/dl) and 25 control patients without hyperbilirubinemia (0.92 +- 0.32 mg/dl) by PCR-direct sequencing.	Bilirubin	103-112	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	9-15
27486402-4	2016	Heme oxygenase-1 (HO-1) forms an important protective mechanism by breaking down heme into the strong anti-oxidants biliverdin/bilirubin and the signaling molecule carbon monoxide.	Bilirubin	127-136	heme oxygenase 1	Rattus norvegicus	0-16
27486402-4	2016	Heme oxygenase-1 (HO-1) forms an important protective mechanism by breaking down heme into the strong anti-oxidants biliverdin/bilirubin and the signaling molecule carbon monoxide.	Bilirubin	127-136	heme oxygenase 1	Rattus norvegicus	18-22
27381978-7	2016	In the human endothelial Ea.hy926 cell line, we demonstrated that intracellular bilirubin (3-5 pmol mg(-1) protein) could be modulated by either extracellular bilirubin uptake, or by up-regulation of heme oxygenase-1, a cellular enzyme related to endogenous bilirubin synthesis.	Bilirubin	80-89	heme oxygenase 1	Homo sapiens	200-216
27386263-10	2016	Serum IL-21 levels correlated positively with total serum bilirubin levels (r = 0.46, p &lt; 0.05), grading of necroinflammatory activity (r = 0.68, p &lt; 0.005) and negatively with serum albumin levels in patients with AIH (r = -0.49, p &lt; 0.05).	Bilirubin	58-67	interleukin 21	Homo sapiens	6-11
27021659-6	2016	IH exposure also increased hepatic expression of HO-1 and iron-binding protein ferritin-1 at the late phase, in association with increase in serum iron, bilirubin, and hepatic levels of lipid peroxides, such as 4-hydroxy-2-nonenal (HNE).	Bilirubin	153-162	heme oxygenase 1	Rattus norvegicus	49-89
27021659-9	2016	The Hb promotes HO-1 expression in KCs, thereby produces iron, bilirubin, and carbon monoxide (CO).	Bilirubin	63-72	heme oxygenase 1	Rattus norvegicus	16-20
26988732-11	2016	Gene expression correlated directly with serum bilirubin and INR (r=0.79; p&lt;0.001 and r=0.67; p&lt;0.001), MELD (r=0.68; p&lt;0.001) and Interleukin-6 (r=0.65; p&lt;0.001).	Bilirubin	47-56	interleukin 6	Homo sapiens	140-153
27350939-7	2016	Significant amelioration of prothrombin time and total bilirubin in LF patients was attributed to G-CSF therapy (OR, -0.064; 95% CI,-0.481 to 0.353; p&lt; 0.001; and OR, -0.803; 95% CI, -1.177 to -0.430; p = 0.000, respectively).	Bilirubin	55-64	colony stimulating factor 3	Homo sapiens	98-103
27060662-2	2016	During neonatal development, delayed expression of the UGT1A1 gene leads to hyperbilirubinemia as determined by elevated levels of total serum bilirubin (TSB).	Bilirubin	81-90	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	55-61
27060662-7	2016	Bilirubin accumulates in brain tissue from hUGT1/Ikkbeta(DeltaIEC) mice inducing an inflammatory state as shown by elevated TNFalpha, IL-1beta and IL-6, all of which can be prevented by neonatal induction of hepatic or intestinal UGT1A1 and lowering of TSB levels.	Bilirubin	0-9	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	43-48
27060662-7	2016	Bilirubin accumulates in brain tissue from hUGT1/Ikkbeta(DeltaIEC) mice inducing an inflammatory state as shown by elevated TNFalpha, IL-1beta and IL-6, all of which can be prevented by neonatal induction of hepatic or intestinal UGT1A1 and lowering of TSB levels.	Bilirubin	0-9	inhibitor of kappaB kinase beta	Mus musculus	49-56
27060662-7	2016	Bilirubin accumulates in brain tissue from hUGT1/Ikkbeta(DeltaIEC) mice inducing an inflammatory state as shown by elevated TNFalpha, IL-1beta and IL-6, all of which can be prevented by neonatal induction of hepatic or intestinal UGT1A1 and lowering of TSB levels.	Bilirubin	0-9	tumor necrosis factor	Mus musculus	124-132
27060662-7	2016	Bilirubin accumulates in brain tissue from hUGT1/Ikkbeta(DeltaIEC) mice inducing an inflammatory state as shown by elevated TNFalpha, IL-1beta and IL-6, all of which can be prevented by neonatal induction of hepatic or intestinal UGT1A1 and lowering of TSB levels.	Bilirubin	0-9	interleukin 1 beta	Mus musculus	134-142
27060662-7	2016	Bilirubin accumulates in brain tissue from hUGT1/Ikkbeta(DeltaIEC) mice inducing an inflammatory state as shown by elevated TNFalpha, IL-1beta and IL-6, all of which can be prevented by neonatal induction of hepatic or intestinal UGT1A1 and lowering of TSB levels.	Bilirubin	0-9	interleukin 6	Mus musculus	147-151
27060662-7	2016	Bilirubin accumulates in brain tissue from hUGT1/Ikkbeta(DeltaIEC) mice inducing an inflammatory state as shown by elevated TNFalpha, IL-1beta and IL-6, all of which can be prevented by neonatal induction of hepatic or intestinal UGT1A1 and lowering of TSB levels.	Bilirubin	0-9	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	230-236
27155841-7	2016	Additionally, we identified a number of genes for which eSNPs were in LD with multiple diseases or traits, including DNASE1L1 which was mapped to bilirubin levels, type 1 diabetes and schizophrenia.	Bilirubin	146-155	deoxyribonuclease 1 like 1	Homo sapiens	117-125
27331362-9	2016	RESULTS: Administration of CD47mAb400 to donor livers increased recipient survival and resulted in significant reduction of serum transaminases, bilirubin, triphosphate nick-end labeling staining, caspase-3 activity, oxidative and nitrosative stresses, and proinflammatory cytokine expression of TNF-alpha, IL-6 and IL-1beta.	Bilirubin	145-154	CD47 molecule	Homo sapiens	27-31
27133300-9	2016	RESULTS: In DMN-treated rats, administration of CGA formula significantly decreased serum ALT, AST and total bilirubin and hepatic hydroxyproline levels, increased serum albumin level, and attenuated liver fibrosis as shown by histological examination.	Bilirubin	109-118	chromogranin A	Rattus norvegicus	48-51
27166185-9	2016	High angiopoietin-2 and basic fibroblast growth factor (bFGF) levels at baseline were associated with grade 3 &lt;= total bilirubin increase and transaminases increase, respectively.	Bilirubin	122-131	angiopoietin 2	Homo sapiens	5-19
27166185-9	2016	High angiopoietin-2 and basic fibroblast growth factor (bFGF) levels at baseline were associated with grade 3 &lt;= total bilirubin increase and transaminases increase, respectively.	Bilirubin	122-131	fibroblast growth factor 2	Homo sapiens	24-54
27166185-9	2016	High angiopoietin-2 and basic fibroblast growth factor (bFGF) levels at baseline were associated with grade 3 &lt;= total bilirubin increase and transaminases increase, respectively.	Bilirubin	122-131	fibroblast growth factor 2	Homo sapiens	56-60
27235212-5	2016	We propose that the activation of G6PD via a small molecule chaperone is a potential strategy to increase endogenous defense against bilirubin-induced oxidative stress and prevent kernicterus.	Bilirubin	133-142	glucose-6-phosphate dehydrogenase	Homo sapiens	34-38
27233360-11	2016	Increased level of urea, creatinine, bilirubin, blood urea nitrogen whereas decreased concentration of proteins in serum of CCl4 treated animals were restored towards the normal level with co-administration of ASM.	Bilirubin	37-46	H19, imprinted maternally expressed transcript (non-protein coding)	Rattus norvegicus	210-213
26841084-8	2016	Bilirubin levels were higher among the study (ABO-incompatible) group during the first 10 days of life; however, no significant differences were found regarding the need for phototherapy.	Bilirubin	0-9	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	46-49
27151334-5	2016	On multivariate Cox regression, initial high TB was a significant predictor of in-hospital MACE (HR, 2.69; 95% CI: 1.67-4.34, P=0.010) and of cardiac death (HR 2.72, 95% CI: 1.67-4.44, P=0.012).	Bilirubin	45-47	cytochrome c oxidase subunit 8A	Homo sapiens	16-19
27060751-8	2016	Among the derivatives, BD1 (dimethyl ester of bilirubin) exhibited ~ 3 fold greater inhibitory potency towards sPLA2IIA compared to UCB.	Bilirubin	46-55	defensin beta 1	Homo sapiens	23-26
27323053-7	2016	The serum bilirubin levels seem to be affected by the homozygosity or heterozygosity of the UGT1A1 gene mutation; 211G&gt;A homozygous mutation is an important factor that causes a rise in bilirubin in neonates with unconjugated hyperbilirubinemia.	Bilirubin	10-19	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	92-98
27323053-7	2016	The serum bilirubin levels seem to be affected by the homozygosity or heterozygosity of the UGT1A1 gene mutation; 211G&gt;A homozygous mutation is an important factor that causes a rise in bilirubin in neonates with unconjugated hyperbilirubinemia.	Bilirubin	189-198	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	92-98
26782094-0	2016	Post-test probability for neonatal hyperbilirubinemia based on umbilical cord blood bilirubin, direct antiglobulin test, and ABO compatibility results.	Bilirubin	40-49	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	125-128
27058902-3	2016	Treatment of EpCAM positive tumor patients with catumaxomab caused dose dependent hepatitis as evidenced by significant elevations in serum alanine- and aspartate aminotransferases, bilirubin, gammaGT and induction of the acute phase C-reactive protein (CRP) and the cytokines IL6 and IL8.	Bilirubin	182-191	epithelial cell adhesion molecule	Homo sapiens	13-18
27087140-5	2016	When mouse bone marrow cells were induced with erythropoietin to differentiate into erythroid cells, the synthesis of bilirubin increased.	Bilirubin	118-127	erythropoietin	Mus musculus	47-61
26782094-6	2016	Clinical factors positively associated with UCB bilirubin were ABO incompatibility, positive DAT, presence of maternal red cell antibodies, alarming visual assessment and significant hyperbilirubinemia in the first 6 days of life.	Bilirubin	48-57	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	63-66
26782094-9	2016	CONCLUSION: Post-test probabilities for neonatal hyperbilirubinemia can be calculated using exponential functions defined by UCB bilirubin, DAT, and ABO compatibility results.	Bilirubin	54-63	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	149-152
26782094-12	2016	What is New:   Post-test probability for hyperbilirubinemia correlated exponentially with umbilical cord blood bilirubin in different risk groups defined by direct antiglobulin test and ABO blood group compatibility results.	Bilirubin	46-55	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	186-189
26395865-4	2016	The BLVRA enzyme is known to convert biliverdin to bilirubin, both of which possess antioxidant activity.	Bilirubin	51-60	biliverdin reductase A	Bos taurus	4-9
26968795-0	2016	Heme oxygenase-1-derived bilirubin counteracts HIV protease inhibitor-mediated endothelial cell dysfunction.	Bilirubin	25-34	heme oxygenase 1	Homo sapiens	0-16
26968795-9	2016	Inhibition of HO-1 activity or expression potentiated the anti-proliferative and inflammatory actions of PIs which was reversed by bilirubin but not carbon monoxide.	Bilirubin	131-140	heme oxygenase 1	Homo sapiens	14-18
26968795-12	2016	Thus, induction of HO-1 via the ROS-Nrf2 pathway in human ECs counteracts the anti-proliferative and inflammatory actions of PIs by generating bilirubin.	Bilirubin	143-152	heme oxygenase 1	Homo sapiens	19-23
26968795-12	2016	Thus, induction of HO-1 via the ROS-Nrf2 pathway in human ECs counteracts the anti-proliferative and inflammatory actions of PIs by generating bilirubin.	Bilirubin	143-152	NFE2 like bZIP transcription factor 2	Homo sapiens	36-40
26852648-10	2016	Apelin was negatively correlated to lactate dehydrogenase, indirect bilirubin, serum ferritin, end systolic diameter, tricuspid regurgitant jet velocity, right ventricle systolic pressure, pulmonary vascular resistance and tissue Doppler imaging S wave.	Bilirubin	68-77	apelin	Homo sapiens	0-6
27122675-9	2016	RESULTS: Among the 120 mCRC patients, the serum bilirubin level was significantly different between the UGT1A1*28 wild-type and mutant genotypes.	Bilirubin	48-57	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	104-110
26417955-1	2016	The antiretroviral protease inhibitor atazanavir inhibits hepatic uridine diphosphate glucuronosyltransferase (UGT) 1A1, thereby preventing the glucuronidation and elimination of bilirubin.	Bilirubin	179-188	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	66-119
26417955-3	2016	Risk for bilirubin-related discontinuation is highest among individuals who carry two UGT1A1 decreased function alleles (UGT1A1*28 or *37).	Bilirubin	9-18	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	86-92
26417955-3	2016	Risk for bilirubin-related discontinuation is highest among individuals who carry two UGT1A1 decreased function alleles (UGT1A1*28 or *37).	Bilirubin	9-18	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	121-127
26968162-2	2016	Contrary to CN type I, patients with CN II exhibit residual capacity to conjugate bilirubin and may present a normal life expectancy.	Bilirubin	82-91	5'-nucleotidase, cytosolic II	Homo sapiens	37-42
27226858-8	2016	CoPP and bilirubin, an inducer of HO-1 and a metabolic product of HO-1, respectively, provided a similar protective effects.	Bilirubin	9-18	heme oxygenase 1	Mus musculus	34-38
27226858-8	2016	CoPP and bilirubin, an inducer of HO-1 and a metabolic product of HO-1, respectively, provided a similar protective effects.	Bilirubin	9-18	heme oxygenase 1	Mus musculus	66-70
25844870-8	2016	Significantly higher "bilirubin decline" rates were reported in both haemolytic and non-haemolytic subgroups treated with the super LED bed compared with a similar sub-population in the conventionally treated group.	Bilirubin	22-31	small integral membrane protein 10 like 2A	Homo sapiens	132-135
26951925-4	2016	In particular, AGP is the most important transporter for basic and neutral drugs, apoD, apoM, and RBP mainly bind endogenous molecules such as progesterone, pregnenolone, bilirubin, sphingosine-1-phosphate, and retinol, while alpha1-m binds the heme.	Bilirubin	171-180	apolipoprotein D	Homo sapiens	82-86
26951925-4	2016	In particular, AGP is the most important transporter for basic and neutral drugs, apoD, apoM, and RBP mainly bind endogenous molecules such as progesterone, pregnenolone, bilirubin, sphingosine-1-phosphate, and retinol, while alpha1-m binds the heme.	Bilirubin	171-180	apolipoprotein M	Homo sapiens	88-92
26951925-4	2016	In particular, AGP is the most important transporter for basic and neutral drugs, apoD, apoM, and RBP mainly bind endogenous molecules such as progesterone, pregnenolone, bilirubin, sphingosine-1-phosphate, and retinol, while alpha1-m binds the heme.	Bilirubin	171-180	retinol binding protein 4	Homo sapiens	98-101
27071062-0	2016	Bilirubin Binding to PPARalpha Inhibits Lipid Accumulation.	Bilirubin	0-9	peroxisome proliferator activated receptor alpha	Mus musculus	21-30
27071062-3	2016	In the present study, we found that bilirubin has a new function as a ligand for PPARalpha.	Bilirubin	36-45	peroxisome proliferator activated receptor alpha	Mus musculus	81-90
27071062-4	2016	We show that bilirubin can bind directly to PPARalpha and increase transcriptional activity.	Bilirubin	13-22	peroxisome proliferator activated receptor alpha	Mus musculus	44-53
27071062-5	2016	When we compared biliverdin, the precursor to bilirubin, on PPARalpha transcriptional activation to known PPARalpha ligands, WY 14,643 and fenofibrate, it showed that fenofibrate and biliverdin have similar activation properties.	Bilirubin	46-55	peroxisome proliferator activated receptor alpha	Mus musculus	60-69
27071062-7	2016	We treated wild-type and PPARalpha KO mice on a high fat diet with fenofibrate or bilirubin for seven days and found that both signal through PPARalpha dependent mechanisms.	Bilirubin	82-91	peroxisome proliferator activated receptor alpha	Mus musculus	25-34
27071062-7	2016	We treated wild-type and PPARalpha KO mice on a high fat diet with fenofibrate or bilirubin for seven days and found that both signal through PPARalpha dependent mechanisms.	Bilirubin	82-91	peroxisome proliferator activated receptor alpha	Mus musculus	142-151
27071062-8	2016	Furthermore, the effect of bilirubin on lowering glucose and reducing body fat percentage was blunted in PPARalpha KO mice.	Bilirubin	27-36	peroxisome proliferator activated receptor alpha	Mus musculus	105-114
27071062-9	2016	These data demonstrate a new function for bilirubin as an agonist of PPARalpha, which mediates the protection from adiposity afforded by moderate increases in bilirubin.	Bilirubin	42-51	peroxisome proliferator activated receptor alpha	Mus musculus	69-78
27071062-9	2016	These data demonstrate a new function for bilirubin as an agonist of PPARalpha, which mediates the protection from adiposity afforded by moderate increases in bilirubin.	Bilirubin	159-168	peroxisome proliferator activated receptor alpha	Mus musculus	69-78
27293091-2	2016	However, special attention was recently given to CAR due to the fact that its key role becomes unveiled in various physiological and pathophysiological processes occurring in the liver: gluconeogenesis, metabolism of fatty acids and bilirubin, hormonal regulation, proliferation of hepatocytes, and hepatocarcinogenesis.	Bilirubin	233-242	nuclear receptor subfamily 1 group I member 3	Homo sapiens	49-52
26973396-11	2016	Increasing pre-treatment model for end-stage liver disease (MELD) score (OR = 1.8, P = 0.033) was associated with severe total bilirubin toxicity.	Bilirubin	127-136	olfactory receptor family 10 subfamily R member 2	Homo sapiens	73-81
26725209-4	2016	TB below 2 mg/dL (34.2 muM) at any time in the first 3 months (TB &lt;2.0, all others TB &gt;= 2) after HPE was examined as a biomarker, using Kaplan-Meier survival and logistic regression.	Bilirubin	0-2	latexin	Homo sapiens	23-26
27031978-3	2016	Among patients with serum AST more than 1000 IU/ml, presence of two of the three following phenomena, within the first 5 days of illness: elevated serum bilirubin, elevated alkaline phosphatise or persistent nausea and vomiting, predicted development of ALF (93.8% sensitivity, 98.7% specificity, 83.3% positive predictive and 99% negative predictive value).	Bilirubin	153-162	solute carrier family 17 member 5	Homo sapiens	26-29
27031978-4	2016	The presence of elevated serum bilirubin, alkaline phosphatase and persistent nausea and vomiting in patients with very high serum AST during the early phase of dengue infection should alert the physician of impending ALF.	Bilirubin	31-40	solute carrier family 17 member 5	Homo sapiens	131-134
26146896-2	2016	Indeed, this is the first report that interested in the study of polymorphisms in genes encoded for enzymes involved in the bilirubin metabolism: rs 4149056 of SLCO1B1 and rs4149000 of SLCO1A2 in combination with rs8175347 and rs887829 of UGT1A1 in order to find a correlation between the polymorphisms studied and the presence of gallstones in a population of sickle cell anemia (SCA) pediatric Tunisians.	Bilirubin	124-133	solute carrier organic anion transporter family member 1B1	Homo sapiens	160-167
26146896-2	2016	Indeed, this is the first report that interested in the study of polymorphisms in genes encoded for enzymes involved in the bilirubin metabolism: rs 4149056 of SLCO1B1 and rs4149000 of SLCO1A2 in combination with rs8175347 and rs887829 of UGT1A1 in order to find a correlation between the polymorphisms studied and the presence of gallstones in a population of sickle cell anemia (SCA) pediatric Tunisians.	Bilirubin	124-133	solute carrier organic anion transporter family member 1A2	Homo sapiens	185-192
26146896-2	2016	Indeed, this is the first report that interested in the study of polymorphisms in genes encoded for enzymes involved in the bilirubin metabolism: rs 4149056 of SLCO1B1 and rs4149000 of SLCO1A2 in combination with rs8175347 and rs887829 of UGT1A1 in order to find a correlation between the polymorphisms studied and the presence of gallstones in a population of sickle cell anemia (SCA) pediatric Tunisians.	Bilirubin	124-133	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	239-245
26589370-9	2016	In different stroke subtypes, AST was independently associated with HT for cardioembolic stroke, BILI for stroke of undetermined aetiology, and no liver function indicators for stroke of large-artery atherosclerosis and small-artery occlusion.	Bilirubin	97-101	solute carrier family 17 member 5	Homo sapiens	30-33
26400407-9	2016	In ACHBLF patients, A20 mRNA was closely associated with total bilirubin, albumin, international normalized ratio, prothrombin time activity and model for end-stage liver disease.	Bilirubin	63-72	immunoglobulin kappa variable 1-27	Homo sapiens	20-23
26863224-7	2016	C18 ceramide is correlated to bilirubin, INR, and creatinine after transplant in DCD.	Bilirubin	30-39	Bardet-Biedl syndrome 9	Homo sapiens	0-3
26223482-6	2016	A univariable analysis revealed that an increase in serum total bilirubin of 1.0 mg/dl or more from baseline was significantly associated with the sex, red blood cell count, serum hemoglobin level, serum alanine aminotransferase level, serum creatinine level and inosine triphosphate pyrophosphatase (ITPA) genotype.	Bilirubin	64-73	glutamic--pyruvic transaminase	Homo sapiens	204-228
26223482-6	2016	A univariable analysis revealed that an increase in serum total bilirubin of 1.0 mg/dl or more from baseline was significantly associated with the sex, red blood cell count, serum hemoglobin level, serum alanine aminotransferase level, serum creatinine level and inosine triphosphate pyrophosphatase (ITPA) genotype.	Bilirubin	64-73	inosine triphosphatase	Homo sapiens	301-305
27051339-5	2016	Our results revealed that miR-122 is an early and sensitive biomarker of hepatocellular injury at a stage when alanine transaminase, aspartate transaminase, and total bilirubin were not detectable.	Bilirubin	167-176	microRNA 122	Rattus norvegicus	26-33
26219405-12	2016	Serum levels of total bilirubin correlated negatively with both ADA (r = -0.38, p = 0.04) and triglyceride (r = -0.45, p = 0.01) in women with GDM.	Bilirubin	22-31	adenosine deaminase	Homo sapiens	64-67
25370011-1	2016	In the Crigler-Najjar type I syndrome, the genetic absence of efficient hepatic glucuronidation of unconjugated bilirubin (UCB) by the uridine 5"-diphospho-glucuronosyltransferase1A1 (UGT1A1) enzyme produces the rise of UCB level in blood.	Bilirubin	112-121	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	135-182
25370011-1	2016	In the Crigler-Najjar type I syndrome, the genetic absence of efficient hepatic glucuronidation of unconjugated bilirubin (UCB) by the uridine 5"-diphospho-glucuronosyltransferase1A1 (UGT1A1) enzyme produces the rise of UCB level in blood.	Bilirubin	112-121	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	184-190
25370011-5	2016	We therefore investigated the functional induction (mRNA, EROD/MROD) and the ability to oxidize bilirubin of Cyp1A1, 1A2, and 2A3 in primary astrocytes cultures obtained from two rat brain region (cortex: Cx and cerebellum: Cll).	Bilirubin	96-105	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	109-115
25370011-7	2016	On the contrary, Cyp1A2 was the most active Cyp in bilirubin clearance without uncoupling, but its induction was confined only in Cx cells.	Bilirubin	51-60	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	17-23
25370011-7	2016	On the contrary, Cyp1A2 was the most active Cyp in bilirubin clearance without uncoupling, but its induction was confined only in Cx cells.	Bilirubin	51-60	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	17-20
25370011-9	2016	In conclusion, the exposure of astrocytes to betaNF plus TCB significantly enhanced Cyp1A1 mediating bilirubin clearance, improving cell viability in both regions.	Bilirubin	101-110	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	84-90
26838806-4	2016	Hepatic overexpression of Bcl2 caused drastic accumulation of serum BA and bilirubin levels and dysregulated BA synthetic enzymes and transporters.	Bilirubin	75-84	B cell leukemia/lymphoma 2	Mus musculus	26-30
26250421-13	2016	Serum bilirubin concentrations of typical CN-2, intermediate group, and typical GS are respectively 12.9 +- 5.1, 5.2 +- 2.2, and 2.8 +- 1.1 mg/dL.	Bilirubin	6-15	carnosine dipeptidase 2	Homo sapiens	42-46
26893654-7	2016	The serum IGF-1 level was found to be significantly associated with hepatitis infection status, Child-Pugh class, bilirubin level, tumor size and nodularity, vascular invasion and the Barcelona Clinic Liver Cancer (BCLC) stage.	Bilirubin	114-123	insulin like growth factor 1	Homo sapiens	10-15
26223708-0	2016	Successful treatment with 4-phenylbutyrate in a patient with benign recurrent intrahepatic cholestasis type 2 refractory to biliary drainage and bilirubin absorption.	Bilirubin	145-154	ATP binding cassette subfamily B member 11	Homo sapiens	61-109
26250421-15	2016	CONCLUSIONS: The serum bilirubin concentration varied continuously from GS to CN-2 depending on genotypes.	Bilirubin	23-32	carnosine dipeptidase 2	Homo sapiens	78-82
27069723-8	2016	RESULTS: There was a significant (P &lt; 0.05) reduction in CCl4 and ACM-induced increases in serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and direct bilirubin at 100 and 300 mg/kg, respectively.	Bilirubin	196-205	C-C motif chemokine ligand 4	Rattus norvegicus	60-64
26134264-11	2016	H-TPO was correlated with liver function (bilirubin r = -0.350, P &lt; 0.001 and international normalized ratio r = -0.227, P = 0.011).	Bilirubin	42-51	thrombopoietin	Homo sapiens	2-5
26631587-9	2016	Key messages Bilirubin levels are inversely related to cardiovascular disease, and overexpression of heme oxygenase-1 (the enzyme that determines bilirubin production) has prevented post-infarction ventricular remodeling in experimental animals, but the association between bilirubin levels and the progression of ventricular volumes and function in patients with acute myocardial infarction remained unexplored.	Bilirubin	146-155	heme oxygenase 1	Homo sapiens	101-117
26786206-0	2016	Corrigendum: Bilirubin Increases Insulin Sensitivity by Regulating Cholesterol Metabolism, Adipokines and PPARgamma Levels.	Bilirubin	13-22	peroxisome proliferator activated receptor gamma	Homo sapiens	106-115
26779023-8	2015	Among the by-products of the HO/BVR system, carbon monoxide (CORM-2, 50 nM) and bilirubin (BR, 50 nM) significantly inhibited TMT-induced superoxide anion formation in SH-SY5Y cells.	Bilirubin	80-89	biliverdin reductase A	Homo sapiens	32-35
26779023-8	2015	Among the by-products of the HO/BVR system, carbon monoxide (CORM-2, 50 nM) and bilirubin (BR, 50 nM) significantly inhibited TMT-induced superoxide anion formation in SH-SY5Y cells.	Bilirubin	91-93	biliverdin reductase A	Homo sapiens	32-35
26779023-9	2015	All together, these results corroborate the neuroprotective effect of FA through the up-regulation of the HO-1/BVR system, via carbon monoxide and BR formation, and provide the first evidence on the role of HO-1/Nrf2 axis in FA-related enhancement of cell stress response in human neurons.	Bilirubin	147-149	heme oxygenase 1	Homo sapiens	106-114
26779023-9	2015	All together, these results corroborate the neuroprotective effect of FA through the up-regulation of the HO-1/BVR system, via carbon monoxide and BR formation, and provide the first evidence on the role of HO-1/Nrf2 axis in FA-related enhancement of cell stress response in human neurons.	Bilirubin	147-149	heme oxygenase 1	Homo sapiens	106-110
26631587-9	2016	Key messages Bilirubin levels are inversely related to cardiovascular disease, and overexpression of heme oxygenase-1 (the enzyme that determines bilirubin production) has prevented post-infarction ventricular remodeling in experimental animals, but the association between bilirubin levels and the progression of ventricular volumes and function in patients with acute myocardial infarction remained unexplored.	Bilirubin	274-283	heme oxygenase 1	Homo sapiens	101-117
27313607-5	2016	In 427 LTx patients, the AUROC curve based on bilirubin and AST at day 1 identified a cutoff of 2.04 mg/dL for the recipient pretransplant bilirubin.	Bilirubin	139-148	solute carrier family 17 member 5	Homo sapiens	60-63
26684255-0	2016	Serum bilirubin levels are inversely associated with PAI-1 and fibrinogen in Korean subjects.	Bilirubin	6-15	serpin family E member 1	Homo sapiens	53-58
26684255-0	2016	Serum bilirubin levels are inversely associated with PAI-1 and fibrinogen in Korean subjects.	Bilirubin	6-15	fibrinogen beta chain	Homo sapiens	63-73
26684255-3	2016	This study investigated the association of serum bilirubin with fibrinogen and plasminogen activator inhibitor-1 (PAI-1), respectively.	Bilirubin	49-58	fibrinogen beta chain	Homo sapiens	64-74
26684255-3	2016	This study investigated the association of serum bilirubin with fibrinogen and plasminogen activator inhibitor-1 (PAI-1), respectively.	Bilirubin	49-58	serpin family E member 1	Homo sapiens	79-112
26684255-3	2016	This study investigated the association of serum bilirubin with fibrinogen and plasminogen activator inhibitor-1 (PAI-1), respectively.	Bilirubin	49-58	serpin family E member 1	Homo sapiens	114-119
26684255-7	2016	Correlation analysis revealed linear relationships of fibrinogen with TB and direct bilirubin (DB), whereas PAI-1 was correlated with DB.	Bilirubin	70-72	fibrinogen beta chain	Homo sapiens	54-64
26684255-7	2016	Correlation analysis revealed linear relationships of fibrinogen with TB and direct bilirubin (DB), whereas PAI-1 was correlated with DB.	Bilirubin	84-93	fibrinogen beta chain	Homo sapiens	54-64
26684255-8	2016	After adjustment for confounding factors, bilirubin levels were inversely associated with fibrinogen and PAI-1 levels, respectively.	Bilirubin	42-51	fibrinogen beta chain	Homo sapiens	90-100
26684255-8	2016	After adjustment for confounding factors, bilirubin levels were inversely associated with fibrinogen and PAI-1 levels, respectively.	Bilirubin	42-51	serpin family E member 1	Homo sapiens	105-110
26684255-9	2016	Multivariate regression models showed a negative linear relationship between all types of bilirubin and fibrinogen, whereas there was a significant linear relationship between PAI-1 and DB.	Bilirubin	90-99	fibrinogen beta chain	Homo sapiens	104-114
26684255-10	2016	CONCLUSIONS: High bilirubin concentrations were independently associated with low levels of fibrinogen and PAI-1, respectively.	Bilirubin	18-27	fibrinogen beta chain	Homo sapiens	92-102
26684255-10	2016	CONCLUSIONS: High bilirubin concentrations were independently associated with low levels of fibrinogen and PAI-1, respectively.	Bilirubin	18-27	serpin family E member 1	Homo sapiens	107-112
26684255-11	2016	The association between TB and PAI-1 was confined to the highest TB concentration category whereas DB showed a linear association with PAI-1.	Bilirubin	24-26	serpin family E member 1	Homo sapiens	31-36
27349017-0	2016	Low Serum Total Bilirubin Concentration was Associated with Increased High Sensitive C Reactive Protein Level in Patients with Impaired Glucose Tolerance and Type 2 Diabetes Mellitus Subjects.	Bilirubin	16-25	C-reactive protein	Homo sapiens	85-103
27349017-9	2016	Meanwhile, the serum TB levels was negatively correlated with serum hs-CRP (P &lt; 0.05) and C-IMT (P &lt; 0.05) in IGT and T2DM.	Bilirubin	21-23	CIMT	Homo sapiens	93-98
27212785-6	2016	An ELISA was performed to detect anti-VEGFR-3 autoantibodies in sera of rats with different degree of liver injury and results were correlated with aminotransferases, total bilirubin, and the relative fibrotic area.	Bilirubin	173-182	Fms related receptor tyrosine kinase 4	Rattus norvegicus	38-45
26875909-6	2016	RESULTS: D-GalN/LPS treatment downregulated SIRT1 expression and markedly increased the aminotransferase, bilirubin and conjugated diene levels.	Bilirubin	106-115	galanin and GMAP prepropeptide	Rattus norvegicus	11-15
26404950-13	2016	Mice that were developing BA and given antibodies against IL17 had lower levels of liver inflammation and mean serum levels of bilirubin than mice receiving control antibodies (191 mumol/L vs 78 mumol/L, P = .002).	Bilirubin	127-136	interleukin 17A	Mus musculus	58-62
26958514-11	2016	Additionally, a statistically significant association was observed between serum prolactin levels with serum bilirubin (rho =0.67, P = 0.04) and aspartate aminotransferase (rho =0.72, P = 0.05).	Bilirubin	109-118	prolactin	Homo sapiens	81-90
26679676-12	2016	The mRNA expression and protein level of TNF-alpha and the mRNA of IL-1beta and MMP-9 were progressively and markedly reduced in bilirubin-treated rats.	Bilirubin	129-138	tumor necrosis factor	Rattus norvegicus	41-50
26679676-12	2016	The mRNA expression and protein level of TNF-alpha and the mRNA of IL-1beta and MMP-9 were progressively and markedly reduced in bilirubin-treated rats.	Bilirubin	129-138	interleukin 1 beta	Rattus norvegicus	67-75
26679676-12	2016	The mRNA expression and protein level of TNF-alpha and the mRNA of IL-1beta and MMP-9 were progressively and markedly reduced in bilirubin-treated rats.	Bilirubin	129-138	matrix metallopeptidase 9	Rattus norvegicus	80-85
26679676-11	2016	HIF-1alpha, VEGF, SDF-1alpha, TGF-beta1, IL-10 mRNA and protein levels were significantly higher on days 3, 7 and 14 in bilirubin-treated rats.	Bilirubin	120-129	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-10
26679676-11	2016	HIF-1alpha, VEGF, SDF-1alpha, TGF-beta1, IL-10 mRNA and protein levels were significantly higher on days 3, 7 and 14 in bilirubin-treated rats.	Bilirubin	120-129	vascular endothelial growth factor A	Rattus norvegicus	12-16
26247507-7	2016	Furthermore, ASP 2 and ASP 3 significantly increased the levels of gamma glutamyl transferase by 70% and 85%; alanine aminotransferase by 66% and 117%; aspartate aminotransferase by 21% and 48%; urea by 72% and 58% and conjugated bilirubin by 63% and 64%, respectively.	Bilirubin	230-239	beta-secretase 1	Rattus norvegicus	13-18
26679676-11	2016	HIF-1alpha, VEGF, SDF-1alpha, TGF-beta1, IL-10 mRNA and protein levels were significantly higher on days 3, 7 and 14 in bilirubin-treated rats.	Bilirubin	120-129	transforming growth factor, beta 1	Rattus norvegicus	30-39
27093468-8	2016	There was significant (P &lt; 0.0001) association between IFN-gamma levels and the fibrosis stages and activity, albumin, platelet count, total bilirubin, and international normalized ratio (INR).	Bilirubin	144-153	interferon gamma	Homo sapiens	58-67
26925435-2	2016	Previous work by our group suggests that bilirubin is able to suppress inflammatory responses by preventing the migration of leukocytes into target tissues through disruption of vascular cell adhesion molecule-1 (VCAM-1)-dependent cell signaling.	Bilirubin	41-50	vascular cell adhesion molecule 1	Mus musculus	178-211
26925435-2	2016	Previous work by our group suggests that bilirubin is able to suppress inflammatory responses by preventing the migration of leukocytes into target tissues through disruption of vascular cell adhesion molecule-1 (VCAM-1)-dependent cell signaling.	Bilirubin	41-50	vascular cell adhesion molecule 1	Mus musculus	213-219
26925435-6	2016	These findings suggest that bilirubin impairs the normal migration of eosinophils into intestinal tissues, as supported by in vitro experiments showing that bilirubin blocks the VCAM-1-dependent movement of Jurkat cells across human endothelial cell monolayers.	Bilirubin	28-37	vascular cell adhesion molecule 1	Homo sapiens	178-184
26925435-6	2016	These findings suggest that bilirubin impairs the normal migration of eosinophils into intestinal tissues, as supported by in vitro experiments showing that bilirubin blocks the VCAM-1-dependent movement of Jurkat cells across human endothelial cell monolayers.	Bilirubin	157-166	vascular cell adhesion molecule 1	Homo sapiens	178-184
26925435-7	2016	Taken together, our findings support that bilirubin ameliorates DSS-induced colitis and disrupts the physiological trafficking of leukocytes to the intestine by preventing transmigration across the vascular endothelium, potentially through the inhibition VCAM-1-mediated signaling.	Bilirubin	42-51	vascular cell adhesion molecule 1	Mus musculus	255-261
27629944-7	2016	PEP occurred in 10% of the patients, with a significantly higher frequency in those with hilar/upper bile duct stricture (p=0.026) and a normal bilirubin level at admission (p=0.016).	Bilirubin	144-153	prolyl endopeptidase	Homo sapiens	0-3
27629944-12	2016	Conclusion Patients with upper/hilar bile duct stricture or a normal bilirubin level are at high risk of developing PEP after preoperative BD.	Bilirubin	69-78	prolyl endopeptidase	Homo sapiens	116-119
27526421-10	2016	Independent predictors of FVIII &gt;= 150% were: fibrinogen (p &lt; 0.001), bilirubin (p = 0.002), hemoglobin (p = 0.016), glucose (p = 0.040), CRP (p = 0.023), total homocysteine (p = 0.032).	Bilirubin	76-85	coagulation factor VIII	Homo sapiens	26-31
26666247-3	2016	The Gilbert genotype, the UGT1A1*28 allele, is the major known genetic cause of variation in bilirubin.	Bilirubin	93-102	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	26-32
27578921-0	2016	Conjugated Bilirubin Differentially Regulates CD4+ T Effector Cells and T Regulatory Cell Function through Outside-In and Inside-Out Mechanisms: The Effects of HAV Cell Surface Receptor and Intracellular Signaling.	Bilirubin	11-20	CD4 molecule	Homo sapiens	46-49
27526421-12	2016	CONCLUSIONS: The activity of FVIII in patients after VTE episode is influenced by age, concentration of fibrinogen, bilirubin, hemoglobin, glucose, CRP and homocysteine.	Bilirubin	116-125	coagulation factor VIII	Homo sapiens	29-34
26741352-9	2015	Bilirubin is known to be an agonist for this receptor, and this may rationalize a recent report that heme oxygenase-1 induction in the liver boosts FGF21 expression.	Bilirubin	0-9	heme oxygenase 1	Mus musculus	101-117
26166253-2	2016	HO-1, a cellular stress protein, serves a vital metabolic function as the rate-limiting step in the degradation of heme to generate carbon monoxide (CO), iron, and biliverdin-IXalpha (BV), the latter which is converted to bilirubin-IXalpha (BR).	Bilirubin	222-239	heme oxygenase 1	Homo sapiens	0-4
26915869-6	2016	There were negative correlations between TGF-beta1 and urea, creatinine, alanine aminotransferase, AST, and total bilirubin.	Bilirubin	114-123	transforming growth factor beta 1	Homo sapiens	41-50
26741352-9	2015	Bilirubin is known to be an agonist for this receptor, and this may rationalize a recent report that heme oxygenase-1 induction in the liver boosts FGF21 expression.	Bilirubin	0-9	fibroblast growth factor 21	Mus musculus	148-153
26741352-10	2015	There is reason to suspect that phycocyanorubin, a bilirubin homolog that is a metabolite of the major phycobilin in spirulina, may share bilirubin"s agonist activity for AhR, and perhaps likewise promote FGF21 induction.	Bilirubin	51-60	aryl-hydrocarbon receptor	Mus musculus	171-174
26741352-10	2015	There is reason to suspect that phycocyanorubin, a bilirubin homolog that is a metabolite of the major phycobilin in spirulina, may share bilirubin"s agonist activity for AhR, and perhaps likewise promote FGF21 induction.	Bilirubin	138-147	aryl-hydrocarbon receptor	Mus musculus	171-174
26741352-10	2015	There is reason to suspect that phycocyanorubin, a bilirubin homolog that is a metabolite of the major phycobilin in spirulina, may share bilirubin"s agonist activity for AhR, and perhaps likewise promote FGF21 induction.	Bilirubin	138-147	fibroblast growth factor 21	Mus musculus	205-210
26659465-5	2015	Our results also showed that CCl4 induced an increase in liver injury parameters like serum ALT, AST, ALP, GGT and bilirubin.	Bilirubin	115-124	C-C motif chemokine ligand 4	Rattus norvegicus	29-33
26391462-0	2015	Heme oxygenase-1-derived bilirubin protects endothelial cells against high glucose-induced damage.	Bilirubin	25-34	heme oxygenase 1	Bos taurus	0-16
26297581-1	2015	The bilirubin (BR) photo-conversion in the human body is a protein-dependent process; an effective photo-isomerization of the potentially neurotoxic Z,Z-BR as well as its oxidation to biliverdin in the antioxidant redox cycle is possible only when BR is bound on serum albumin.	Bilirubin	4-13	albumin	Homo sapiens	263-276
26297581-1	2015	The bilirubin (BR) photo-conversion in the human body is a protein-dependent process; an effective photo-isomerization of the potentially neurotoxic Z,Z-BR as well as its oxidation to biliverdin in the antioxidant redox cycle is possible only when BR is bound on serum albumin.	Bilirubin	15-17	albumin	Homo sapiens	263-276
25700934-2	2015	The aim of our study was to evaluate the impact of serum bilirubin on kidney prognosis in IgA nephropathy (IgAN).	Bilirubin	57-66	IGAN1	Homo sapiens	107-111
25700934-11	2015	CONCLUSIONS: We demonstrated that lower bilirubin levels were significantly associated with higher risk of ESRD in IgAN.	Bilirubin	40-49	IGAN1	Homo sapiens	115-119
25700934-12	2015	In addition, bilirubin provided incremental predictive value in the risk assessment for progression of IgAN beyond that provided by standard risk factors.	Bilirubin	13-22	IGAN1	Homo sapiens	103-107
26188155-1	2015	Constitutive androstane receptor (CAR) encoded by the nuclear receptor subfamily 1, group I, member 3 (NR1I3) gene regulates the elimination of bilirubin through activating the components of the bilirubin clearance pathway.	Bilirubin	195-204	nuclear receptor subfamily 1 group I member 3	Homo sapiens	54-101
26188155-1	2015	Constitutive androstane receptor (CAR) encoded by the nuclear receptor subfamily 1, group I, member 3 (NR1I3) gene regulates the elimination of bilirubin through activating the components of the bilirubin clearance pathway.	Bilirubin	195-204	nuclear receptor subfamily 1 group I member 3	Homo sapiens	103-108
26188155-2	2015	Hence, NR1I3 genetic variants may affect bilirubin metabolism and result in neonatal hyperbilirubinemia.	Bilirubin	41-50	nuclear receptor subfamily 1 group I member 3	Homo sapiens	7-12
26391462-8	2015	Upregulation of HO-1 provides cytoprotection against high glucose-induced oxidative stress through the antioxidant properties of bilirubin.	Bilirubin	129-138	heme oxygenase 1	Bos taurus	16-20
26628212-0	2015	Serum bilirubin concentration is modified by UGT1A1 haplotypes and influences risk of type-2 diabetes in the Norfolk Island genetic isolate.	Bilirubin	6-15	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	45-51
26628212-5	2015	Strong linkage disequilibrium was observed across a 200 kb region spanning the UDP-glucuronosyltransferase family, including UGT1A1, an enzyme known to metabolise bilirubin.	Bilirubin	163-172	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	125-131
26628212-9	2015	CONCLUSIONS: In summary, a pedigree-based GWAS of blood-based clinical traits in the Norfolk Island population has identified variants within the UDPGT family directly associated with serum bilirubin levels, which is in turn implicated with reduced risk of developing type-2 diabetes within this population.	Bilirubin	190-199	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	146-151
26195313-9	2015	Within the PSC group, K18 levels significantly correlated with AST (r = 0.5, p = 0.002), alkaline phosphatase (r = 0.5, p = 0.001), total bilirubin (r = 0.61, p &lt;= 0.001), and albumin (r = -0.4, p = 0.02).	Bilirubin	138-147	keratin 18	Homo sapiens	22-25
26188155-1	2015	Constitutive androstane receptor (CAR) encoded by the nuclear receptor subfamily 1, group I, member 3 (NR1I3) gene regulates the elimination of bilirubin through activating the components of the bilirubin clearance pathway.	Bilirubin	144-153	nuclear receptor subfamily 1 group I member 3	Homo sapiens	0-32
26188155-1	2015	Constitutive androstane receptor (CAR) encoded by the nuclear receptor subfamily 1, group I, member 3 (NR1I3) gene regulates the elimination of bilirubin through activating the components of the bilirubin clearance pathway.	Bilirubin	144-153	nuclear receptor subfamily 1 group I member 3	Homo sapiens	34-37
26188155-1	2015	Constitutive androstane receptor (CAR) encoded by the nuclear receptor subfamily 1, group I, member 3 (NR1I3) gene regulates the elimination of bilirubin through activating the components of the bilirubin clearance pathway.	Bilirubin	144-153	nuclear receptor subfamily 1 group I member 3	Homo sapiens	54-101
26188155-1	2015	Constitutive androstane receptor (CAR) encoded by the nuclear receptor subfamily 1, group I, member 3 (NR1I3) gene regulates the elimination of bilirubin through activating the components of the bilirubin clearance pathway.	Bilirubin	144-153	nuclear receptor subfamily 1 group I member 3	Homo sapiens	103-108
26188155-1	2015	Constitutive androstane receptor (CAR) encoded by the nuclear receptor subfamily 1, group I, member 3 (NR1I3) gene regulates the elimination of bilirubin through activating the components of the bilirubin clearance pathway.	Bilirubin	195-204	nuclear receptor subfamily 1 group I member 3	Homo sapiens	0-32
26188155-1	2015	Constitutive androstane receptor (CAR) encoded by the nuclear receptor subfamily 1, group I, member 3 (NR1I3) gene regulates the elimination of bilirubin through activating the components of the bilirubin clearance pathway.	Bilirubin	195-204	nuclear receptor subfamily 1 group I member 3	Homo sapiens	34-37
26670445-10	2015	The TLR4 levels on CD4(+) and CD8(+) T cells were positively correlated with serum total bilirubin (TBIL), direct bilirubin (DBIL), international normalized ratio (INR) levels and white blood cells (WBCs), and negatively correlated with serum albumin (ALB) levels in the HBV-infected patients, indicating TLR4 pathway may play a role in the disease aggravation of ACLF.	Bilirubin	100-104	toll like receptor 4	Homo sapiens	4-8
26212029-1	2015	BACKGROUND &amp; AIMS: Multidrug resistance-associated protein 2 (MRP2) excretes conjugated organic anions including bilirubin and bile acids.	Bilirubin	117-126	ATP binding cassette subfamily C member 2	Homo sapiens	23-64
26212029-1	2015	BACKGROUND &amp; AIMS: Multidrug resistance-associated protein 2 (MRP2) excretes conjugated organic anions including bilirubin and bile acids.	Bilirubin	117-126	ATP binding cassette subfamily C member 2	Homo sapiens	66-70
26220753-1	2015	Crigler-Najjar syndrome presents as severe unconjugated hyperbilirubinemia and is characteristically caused by a mutation in the UGT1A1 gene, encoding the enzyme responsible for bilirubin glucuronidation.	Bilirubin	61-70	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	129-135
26670445-10	2015	The TLR4 levels on CD4(+) and CD8(+) T cells were positively correlated with serum total bilirubin (TBIL), direct bilirubin (DBIL), international normalized ratio (INR) levels and white blood cells (WBCs), and negatively correlated with serum albumin (ALB) levels in the HBV-infected patients, indicating TLR4 pathway may play a role in the disease aggravation of ACLF.	Bilirubin	89-98	toll like receptor 4	Homo sapiens	4-8
26670445-10	2015	The TLR4 levels on CD4(+) and CD8(+) T cells were positively correlated with serum total bilirubin (TBIL), direct bilirubin (DBIL), international normalized ratio (INR) levels and white blood cells (WBCs), and negatively correlated with serum albumin (ALB) levels in the HBV-infected patients, indicating TLR4 pathway may play a role in the disease aggravation of ACLF.	Bilirubin	89-98	CD4 molecule	Homo sapiens	19-22
26670445-10	2015	The TLR4 levels on CD4(+) and CD8(+) T cells were positively correlated with serum total bilirubin (TBIL), direct bilirubin (DBIL), international normalized ratio (INR) levels and white blood cells (WBCs), and negatively correlated with serum albumin (ALB) levels in the HBV-infected patients, indicating TLR4 pathway may play a role in the disease aggravation of ACLF.	Bilirubin	114-123	toll like receptor 4	Homo sapiens	4-8
26670445-10	2015	The TLR4 levels on CD4(+) and CD8(+) T cells were positively correlated with serum total bilirubin (TBIL), direct bilirubin (DBIL), international normalized ratio (INR) levels and white blood cells (WBCs), and negatively correlated with serum albumin (ALB) levels in the HBV-infected patients, indicating TLR4 pathway may play a role in the disease aggravation of ACLF.	Bilirubin	114-123	CD4 molecule	Homo sapiens	19-22
26399598-4	2015	Consistent with this result, compared with cells and membranes from control mice, isolated hepatocytes, and liver plasma membranes from Atp11c mutant mice had a much lower uptake of [(3)H]17beta estradiol 17beta-d-glucuronide and expression of organic anion-transporting polypeptides, which are transporters responsible for hepatic uptake of unconjugated BAs and organic anions, including bilirubin glucuronides.	Bilirubin	389-398	ATPase, class VI, type 11C	Mus musculus	136-142
26717404-6	2015	Clinical and laboratory parameters were obtained.In the present study, the relative expression of A20 mRNA was significantly increased in CHB patients compared with HCs and was positively associated with alanine aminotransferase, aspartate aminotransferase, and total bilirubin.	Bilirubin	268-277	TNF alpha induced protein 3	Homo sapiens	98-101
26499888-13	2015	The comparisons between the high CPS1 expression group and the low expression group indicated significant differences in international normalized ratio (P=0.048), total protein (P=0.049), indirect bilirubin (P=0.025), alkaline phosphatase (P=0.003) and disease-free survival (P=0.034).	Bilirubin	197-206	carbamoyl-phosphate synthase 1	Homo sapiens	33-37
26342858-3	2015	Bilirubin undergoes selective metabolism by UDP-glucuronosyltransferase (UGT) 1A1 and becomes a water soluble glucuronide.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	44-81
26381705-0	2015	Bilirubin prevents acute DSS-induced colitis by inhibiting leukocyte infiltration and suppressing upregulation of inducible nitric oxide synthase.	Bilirubin	0-9	nitric oxide synthase 2, inducible	Mus musculus	114-145
26381705-1	2015	Bilirubin is thought to exert anti-inflammatory effects by inhibiting vascular cell adhesion molecule-1 (VCAM-1)-dependent leukocyte migration and by suppressing the expression of inducible nitric oxide synthase (iNOS).	Bilirubin	0-9	vascular cell adhesion molecule 1	Mus musculus	70-103
26381705-1	2015	Bilirubin is thought to exert anti-inflammatory effects by inhibiting vascular cell adhesion molecule-1 (VCAM-1)-dependent leukocyte migration and by suppressing the expression of inducible nitric oxide synthase (iNOS).	Bilirubin	0-9	vascular cell adhesion molecule 1	Mus musculus	105-111
26381705-1	2015	Bilirubin is thought to exert anti-inflammatory effects by inhibiting vascular cell adhesion molecule-1 (VCAM-1)-dependent leukocyte migration and by suppressing the expression of inducible nitric oxide synthase (iNOS).	Bilirubin	0-9	nitric oxide synthase 2, inducible	Mus musculus	180-211
26381705-1	2015	Bilirubin is thought to exert anti-inflammatory effects by inhibiting vascular cell adhesion molecule-1 (VCAM-1)-dependent leukocyte migration and by suppressing the expression of inducible nitric oxide synthase (iNOS).	Bilirubin	0-9	nitric oxide synthase 2, inducible	Mus musculus	213-217
26381705-7	2015	Concordantly, histopathological analyses revealed that bilirubin-treated mice manifested significantly less colonic injury, including reduced infiltration of eosinophils, lymphocytes, and monocytes, and diminished iNOS expression.	Bilirubin	55-64	nitric oxide synthase 2, inducible	Mus musculus	214-218
26381705-10	2015	In conclusion, bilirubin prevents DSS-induced colitis by inhibiting the migration of leukocytes across the vascular endothelium and by suppressing iNOS expression.	Bilirubin	15-24	nitric oxide synthase 2, inducible	Mus musculus	147-151
26589287-6	2015	The number of CTGF-positive cells provided the most reliable overall measure for disease progression at histological level, bilirubin at biochemical level, and metalloproteinase inhibitor 1 (Timp1) at transcript level.	Bilirubin	124-133	cellular communication network factor 2	Mus musculus	14-18
26134126-0	2015	Bilirubin exerts pro-angiogenic property through Akt-eNOS-dependent pathway.	Bilirubin	0-9	thymoma viral proto-oncogene 1	Mus musculus	49-52
26348140-3	2015	This study aimed to investigate the inhibitory effects of FP extract and its major constituents against human UDP-glucuronosyltransferase 1A1 (UGT1A1), the key enzyme responsible for metabolic elimination of bilirubin.	Bilirubin	208-217	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	110-141
26348140-3	2015	This study aimed to investigate the inhibitory effects of FP extract and its major constituents against human UDP-glucuronosyltransferase 1A1 (UGT1A1), the key enzyme responsible for metabolic elimination of bilirubin.	Bilirubin	208-217	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	143-149
26276582-9	2015	These results indicate that TAK-875 inhibited the efflux transporter MRP2/Mrp2 and uptake transporters Ntcp and OATP/Oatp, which may affect bile acid and bilirubin homeostasis, resulting in hyperbilirubinemia and cholestatic hepatotoxicity.	Bilirubin	154-163	ATP binding cassette subfamily C member 2	Rattus norvegicus	69-73
26276582-9	2015	These results indicate that TAK-875 inhibited the efflux transporter MRP2/Mrp2 and uptake transporters Ntcp and OATP/Oatp, which may affect bile acid and bilirubin homeostasis, resulting in hyperbilirubinemia and cholestatic hepatotoxicity.	Bilirubin	154-163	ATP binding cassette subfamily C member 2	Rattus norvegicus	74-78
26276582-9	2015	These results indicate that TAK-875 inhibited the efflux transporter MRP2/Mrp2 and uptake transporters Ntcp and OATP/Oatp, which may affect bile acid and bilirubin homeostasis, resulting in hyperbilirubinemia and cholestatic hepatotoxicity.	Bilirubin	154-163	solute carrier family 10 member 1	Rattus norvegicus	103-107
26134126-0	2015	Bilirubin exerts pro-angiogenic property through Akt-eNOS-dependent pathway.	Bilirubin	0-9	nitric oxide synthase 3, endothelial cell	Mus musculus	53-57
26134126-6	2015	The phosphorylated levels of endothelial nitric oxide synthase (eNOS) and Akt were increased in ischemic skeletal muscles of mice with bilirubin treatment compared with vehicle treatment.	Bilirubin	135-144	nitric oxide synthase 3, endothelial cell	Mus musculus	29-62
26134126-6	2015	The phosphorylated levels of endothelial nitric oxide synthase (eNOS) and Akt were increased in ischemic skeletal muscles of mice with bilirubin treatment compared with vehicle treatment.	Bilirubin	135-144	nitric oxide synthase 3, endothelial cell	Mus musculus	64-68
26134126-6	2015	The phosphorylated levels of endothelial nitric oxide synthase (eNOS) and Akt were increased in ischemic skeletal muscles of mice with bilirubin treatment compared with vehicle treatment.	Bilirubin	135-144	thymoma viral proto-oncogene 1	Mus musculus	74-77
26134126-7	2015	In in vitro experiments by using human aortic endothelial cells, bilirubin augmented eNOS and Akt phosphorylation, cell proliferation, cell migration and tube formation.	Bilirubin	65-74	nitric oxide synthase 3	Homo sapiens	85-89
26134126-7	2015	In in vitro experiments by using human aortic endothelial cells, bilirubin augmented eNOS and Akt phosphorylation, cell proliferation, cell migration and tube formation.	Bilirubin	65-74	AKT serine/threonine kinase 1	Homo sapiens	94-97
26134126-9	2015	In conclusion, bilirubin promotes angiogenesis through endothelial cells activation via Akt-eNOS-dependent manner.	Bilirubin	15-24	thymoma viral proto-oncogene 1	Mus musculus	88-91
26134126-9	2015	In conclusion, bilirubin promotes angiogenesis through endothelial cells activation via Akt-eNOS-dependent manner.	Bilirubin	15-24	nitric oxide synthase 3, endothelial cell	Mus musculus	92-96
26674516-9	2015	Also basal PON1 activity was positively correlated with serum total protein and albumin, and negatively correlated with serum total bilirubin, alanine amino transferase (ALT), and alkaline phosphatase (ALP) (p&lt; 0.001) in chronic hepatitis cases but not in healthy controls.	Bilirubin	132-141	paraoxonase 1	Homo sapiens	11-15
26516376-3	2015	RESULTS: We found that aberrant PPAR-gamma promoter methylation was attenuated in ACHBLF patients compared with CHB patients and was responsible for the elevated PPAR-gamma expression level, which was negatively correlated with total bilirubin and international normalized ratio.	Bilirubin	234-243	peroxisome proliferator activated receptor gamma	Homo sapiens	32-42
26543529-0	2015	Serum Total Bilirubin, not Cholelithiasis, is Influenced by UGT1A1 Polymorphism, Alpha Thalassemia and beta(s) Haplotype: First Report on Comparison between Arab-Indian and African beta(s) Genes.	Bilirubin	12-21	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	60-66
26543529-4	2015	RESULTS: The mean serum total bilirubin level was significantly higher in the homozygous UGT1A1(AT)7 group as compared to UGT1A1(AT)6 group.	Bilirubin	30-39	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	89-95
26543529-5	2015	Thus, not cholelithiasis but total serum bilirubin was influenced by UGT1A1 polymorphism in this SCA cohort.	Bilirubin	41-50	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	69-75
26543529-6	2015	CONCLUSION: As observed in other population groups, the UGT1A1 (AT)7 homozygosity was significantly associated with raised serum total bilirubin level, but the prevalence of gallstones in the Omani SCA patients was not associated with alpha thalassaemia, UGT1A1 polymorphism, or beta(s) haplotypes.	Bilirubin	135-144	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	56-62
25773774-4	2015	RESULTS: Significant independent determinants of serum WFA(+)-M2BP levels included pathological diagnosis of cirrhosis, female gender, hepatitis C virus (HCV) infection, and liver dysfunction characteristics, such as abnormal indocyanine green retention rate at 15 min, platelet counts, albumin levels, alanine aminotransferase levels, and total bilirubin levels.	Bilirubin	346-355	galectin 3 binding protein	Homo sapiens	62-66
26516376-3	2015	RESULTS: We found that aberrant PPAR-gamma promoter methylation was attenuated in ACHBLF patients compared with CHB patients and was responsible for the elevated PPAR-gamma expression level, which was negatively correlated with total bilirubin and international normalized ratio.	Bilirubin	234-243	peroxisome proliferator activated receptor gamma	Homo sapiens	162-172
26057938-0	2015	Bilirubin scavenges chloramines and inhibits myeloperoxidase-induced protein/lipid oxidation in physiologically relevant hyperbilirubinemic serum.	Bilirubin	0-9	myeloperoxidase	Rattus norvegicus	45-60
26508316-9	2015	RESULTS: Compared with the sham group, the liver function was worse in CCl4 group, manifested as increased levels of serum alanine aminotransferase, aspartate aminotransferase and total bilirubin.	Bilirubin	186-195	C-C motif chemokine ligand 4	Rattus norvegicus	71-75
26459859-0	2015	Unconjugated Bilirubin exerts Pro-Apoptotic Effect on Platelets via p38-MAPK activation.	Bilirubin	13-22	mitogen-activated protein kinase 14	Homo sapiens	68-71
26459859-8	2015	All these parameters conclude that elevated unconjugated bilirubin causes thrombocytopenia by stimulating platelet apoptosis via mitochondrial ROS-induced p38 and p53 activation.	Bilirubin	57-66	mitogen-activated protein kinase 14	Homo sapiens	155-158
26459859-8	2015	All these parameters conclude that elevated unconjugated bilirubin causes thrombocytopenia by stimulating platelet apoptosis via mitochondrial ROS-induced p38 and p53 activation.	Bilirubin	57-66	tumor protein p53	Homo sapiens	163-166
26232645-11	2015	Bilirubin suppressed the smoke-induced systemic and regional oxidative lipid damage associated with increased SOD activity.	Bilirubin	0-9	superoxide dismutase 1	Homo sapiens	110-113
26232645-12	2015	CONCLUSION: Bilirubin attenuated smoking-induced pulmonary injury by suppressing inflammatory cell recruitment and pro-inflammatory cytokine secretion, increasing anti-inflammatory cytokine levels, and anti-oxidant SOD activity in a rat model of smoke-induced emphysema.	Bilirubin	12-21	superoxide dismutase 1	Homo sapiens	215-218
25559211-11	2015	Within the time frame of 1 day before to 4 days after a neurological event, correlations of NSE to HAPT (rs = -0.540) and HPX (rs = -0.611) in negative and to frHB (rs = 0.757), LDH (rs = 0.862) and TBIL (rs = 0.549) in positive direction were established (all P &lt; 0.05).	Bilirubin	199-203	enolase 2	Homo sapiens	92-95
26231934-0	2015	Application of phenol red as a marker ligand for bilirubin binding site at subdomain IIA on human serum albumin.	Bilirubin	49-58	albumin	Homo sapiens	98-111
26231934-2	2015	In order to examine whether phenol red (PhRed) can be used as a marker for bilirubin binding site located in subdomain IIA the interaction between PhRed and human serum albumin (HSA) in buffer solution or in normal and pathological sera solutions with different HSA:bilirubin molar ratio was investigated using absorption/absorption difference spectroscopy and molecular docking method.	Bilirubin	266-275	albumin	Homo sapiens	163-176
25576335-0	2015	Does corticosteroid treatment cause prolonged recovery and increased total bilirubin level in severe ADAMTS-13-deficient TTP patient?	Bilirubin	75-84	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	101-110
25576335-13	2015	In this case, corticosteroid treatment was linked with the increase of total bilirubin level in severe ADAMTS-13-deficient TTP patient.	Bilirubin	77-86	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	103-112
26413716-6	2015	RESULTS: Consistent with previous results, a strong association signal has been detected for UGT1A gene cluster (best SNP rs887829, beta = 0.15, p = 1.30x10-118) for total serum bilirubin level.	Bilirubin	178-187	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	93-98
26413716-11	2015	Additional known effects for total serum bilirubin were also confirmed including organic anion transporters SLCO1B1-SLCO1B3, TDRP and ZMYND8 at FDR&lt;0.05 with no gene-gene interaction effects.	Bilirubin	41-50	solute carrier organic anion transporter family member 1B1	Homo sapiens	108-115
26413716-11	2015	Additional known effects for total serum bilirubin were also confirmed including organic anion transporters SLCO1B1-SLCO1B3, TDRP and ZMYND8 at FDR&lt;0.05 with no gene-gene interaction effects.	Bilirubin	41-50	solute carrier organic anion transporter family member 1B3	Homo sapiens	116-123
26413716-11	2015	Additional known effects for total serum bilirubin were also confirmed including organic anion transporters SLCO1B1-SLCO1B3, TDRP and ZMYND8 at FDR&lt;0.05 with no gene-gene interaction effects.	Bilirubin	41-50	testis development related protein	Homo sapiens	125-129
26413716-11	2015	Additional known effects for total serum bilirubin were also confirmed including organic anion transporters SLCO1B1-SLCO1B3, TDRP and ZMYND8 at FDR&lt;0.05 with no gene-gene interaction effects.	Bilirubin	41-50	zinc finger MYND-type containing 8	Homo sapiens	134-140
26413716-15	2015	In addition, our findings indicate that similar to the adult population, the UGT1A1 is the main locus responsible for normal variation of serum bilirubin in pediatric populations.	Bilirubin	144-153	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	77-83
26232645-10	2015	Administration of bilirubin reduced mean linear intercept and mean alveoli area, increased mean alveoli number, reduced macrophage, neutrophil and TNF-alpha content of BALF, and increased BALF and serum IL-10 level, but lowered local and systemic CCL2, CXCL2, CXCL8 and IL-17 levels.	Bilirubin	18-27	tumor necrosis factor	Homo sapiens	147-156
26232645-10	2015	Administration of bilirubin reduced mean linear intercept and mean alveoli area, increased mean alveoli number, reduced macrophage, neutrophil and TNF-alpha content of BALF, and increased BALF and serum IL-10 level, but lowered local and systemic CCL2, CXCL2, CXCL8 and IL-17 levels.	Bilirubin	18-27	interleukin 10	Homo sapiens	203-208
26232645-10	2015	Administration of bilirubin reduced mean linear intercept and mean alveoli area, increased mean alveoli number, reduced macrophage, neutrophil and TNF-alpha content of BALF, and increased BALF and serum IL-10 level, but lowered local and systemic CCL2, CXCL2, CXCL8 and IL-17 levels.	Bilirubin	18-27	C-C motif chemokine ligand 2	Homo sapiens	247-251
26232645-10	2015	Administration of bilirubin reduced mean linear intercept and mean alveoli area, increased mean alveoli number, reduced macrophage, neutrophil and TNF-alpha content of BALF, and increased BALF and serum IL-10 level, but lowered local and systemic CCL2, CXCL2, CXCL8 and IL-17 levels.	Bilirubin	18-27	C-X-C motif chemokine ligand 2	Homo sapiens	253-258
26232645-10	2015	Administration of bilirubin reduced mean linear intercept and mean alveoli area, increased mean alveoli number, reduced macrophage, neutrophil and TNF-alpha content of BALF, and increased BALF and serum IL-10 level, but lowered local and systemic CCL2, CXCL2, CXCL8 and IL-17 levels.	Bilirubin	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	260-265
26232645-10	2015	Administration of bilirubin reduced mean linear intercept and mean alveoli area, increased mean alveoli number, reduced macrophage, neutrophil and TNF-alpha content of BALF, and increased BALF and serum IL-10 level, but lowered local and systemic CCL2, CXCL2, CXCL8 and IL-17 levels.	Bilirubin	18-27	interleukin 17A	Homo sapiens	270-275
26426612-11	2015	A20 expression on monocytes from patients with ACHBLF was positively correlated with total bilirubin (r = 0.60, P = 0.0001), direct bilirubin (r = 0.63, P &lt; 0.0001), and MELD score (r = 0.43, P = 0.008), and inversely with prothrombin activity (r = -0.33, P = 0.046).	Bilirubin	91-100	immunoglobulin kappa variable 1-27	Homo sapiens	0-3
26274721-8	2015	Furthermore, dexmedetomidine reversed the arrest of cell cycle and the downregulation of the transforming growth factorbeta, phosphorylated mammalian target of rapamycin, and p42/44 mitogen-activated protein kinase induced by bilirubin.	Bilirubin	226-235	cyclin dependent kinase 20	Homo sapiens	175-178
26426612-11	2015	A20 expression on monocytes from patients with ACHBLF was positively correlated with total bilirubin (r = 0.60, P = 0.0001), direct bilirubin (r = 0.63, P &lt; 0.0001), and MELD score (r = 0.43, P = 0.008), and inversely with prothrombin activity (r = -0.33, P = 0.046).	Bilirubin	132-141	immunoglobulin kappa variable 1-27	Homo sapiens	0-3
25922869-1	2015	BACKGROUND: In vitro and animal studies indicate that statins increase heme oxygenase-1 gene (HMOX1) expression, which then, presumably, increases plasma bilirubin concentration.	Bilirubin	154-163	heme oxygenase 1	Homo sapiens	94-99
26072390-8	2015	Poor responders had a higher conjugated/unconjugated bilirubin ratio, indicating increased UGT1A1 activity.	Bilirubin	53-62	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	91-97
26270345-8	2015	Although two other products of HO-1 activity--CO and bilirubin--have been invoked to explain HO-1-mediated cytoprotection, we conclude that, at least in this experimental system, HO-1 activity triggers the induction of ferritin and the latter is actually responsible for the cytoprotective effects of HO-1 activity.	Bilirubin	53-62	heme oxygenase 1	Homo sapiens	31-35
26292095-1	2015	Multidrug resistance-associated protein 2 (MRP2) plays an important role in bile acid metabolism by transporting toxic organic anion conjugates, including conjugated bilirubin, glutathione, sulfate, and multifarious drugs.	Bilirubin	166-175	ATP binding cassette subfamily C member 2	Homo sapiens	0-41
26292095-1	2015	Multidrug resistance-associated protein 2 (MRP2) plays an important role in bile acid metabolism by transporting toxic organic anion conjugates, including conjugated bilirubin, glutathione, sulfate, and multifarious drugs.	Bilirubin	166-175	ATP binding cassette subfamily C member 2	Homo sapiens	43-47
26270345-8	2015	Although two other products of HO-1 activity--CO and bilirubin--have been invoked to explain HO-1-mediated cytoprotection, we conclude that, at least in this experimental system, HO-1 activity triggers the induction of ferritin and the latter is actually responsible for the cytoprotective effects of HO-1 activity.	Bilirubin	53-62	heme oxygenase 1	Homo sapiens	93-97
26270345-8	2015	Although two other products of HO-1 activity--CO and bilirubin--have been invoked to explain HO-1-mediated cytoprotection, we conclude that, at least in this experimental system, HO-1 activity triggers the induction of ferritin and the latter is actually responsible for the cytoprotective effects of HO-1 activity.	Bilirubin	53-62	heme oxygenase 1	Homo sapiens	93-97
26270345-8	2015	Although two other products of HO-1 activity--CO and bilirubin--have been invoked to explain HO-1-mediated cytoprotection, we conclude that, at least in this experimental system, HO-1 activity triggers the induction of ferritin and the latter is actually responsible for the cytoprotective effects of HO-1 activity.	Bilirubin	53-62	heme oxygenase 1	Homo sapiens	93-97
26247603-10	2015	There are human-specific changes in the sequence of the promoter and the protein-coding sequence of uridine diphosphoglucuronosyltransferase 1 (UGT1A1), the enzyme that transforms bilirubin and toxic plant compounds into water-soluble, excretable metabolites.	Bilirubin	180-189	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	144-150
26040771-8	2015	GSTP1 methylation level was significantly correlated with total bilirubin (r = 0.29, P &lt; 0.01), prothrombin time activity (r = -0.24, P = 0.01) and model for end-stage liver disease (MELD) score (r = 0.26, P = 0.01).	Bilirubin	64-73	glutathione S-transferase pi 1	Homo sapiens	0-5
26247603-11	2015	Experimental evidence that UGT1A1 is down-regulated in the human liver suggests that changes in the promoter may be responsible for the human-specific increase in bilirubin.	Bilirubin	163-172	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	27-33
26247603-12	2015	We speculate that since cooking reduces toxic plant compounds, consumption of cooked foods, which is specific to humans, may have resulted in relaxed constraint on UGT1A1 which has in turn led to higher serum levels of bilirubin in humans.	Bilirubin	219-228	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	164-170
24429801-7	2015	In addition, the aortic MIF expression was associated with the levels of triglycerides, total cholesterol, low density lipoprotein cholesterol, lipoprotein (a), apolipoprotein B, total bilirubin, direct bilirubin, indirect bilirubin and coronary severity scores in simple regression analysis.	Bilirubin	185-194	macrophage migration inhibitory factor	Homo sapiens	24-27
26146882-4	2015	Using this distinct fluorescence measure, we found that poorly differentiated hepatocellular carcinoma (HCC) tissues on average showed 3.7 times lower concentration of bilirubins than the corresponding nontumor parts.	Bilirubin	168-178	HCC	Homo sapiens	104-107
24925637-6	2015	Compared with the wild type, the serum levels of albumin (ALB), total protein, total bilirubin and direct bilirubin in IL-10-deficient mice were significantly decreased (P &lt; 0.05).	Bilirubin	85-94	interleukin 10	Mus musculus	119-124
24925637-6	2015	Compared with the wild type, the serum levels of albumin (ALB), total protein, total bilirubin and direct bilirubin in IL-10-deficient mice were significantly decreased (P &lt; 0.05).	Bilirubin	106-115	interleukin 10	Mus musculus	119-124
24925637-9	2015	The absence of IL-10 gene can significantly decrease serum ALB and bilirubin.	Bilirubin	67-76	interleukin 10	Mus musculus	15-20
24429801-7	2015	In addition, the aortic MIF expression was associated with the levels of triglycerides, total cholesterol, low density lipoprotein cholesterol, lipoprotein (a), apolipoprotein B, total bilirubin, direct bilirubin, indirect bilirubin and coronary severity scores in simple regression analysis.	Bilirubin	203-212	macrophage migration inhibitory factor	Homo sapiens	24-27
24429801-7	2015	In addition, the aortic MIF expression was associated with the levels of triglycerides, total cholesterol, low density lipoprotein cholesterol, lipoprotein (a), apolipoprotein B, total bilirubin, direct bilirubin, indirect bilirubin and coronary severity scores in simple regression analysis.	Bilirubin	203-212	macrophage migration inhibitory factor	Homo sapiens	24-27
25611851-9	2015	Furthermore, we reported our present work on genetic analysis of mutations of UGT1A1 gene, and the correlation of UGT1A1 mutations with serum total bilirubin levels in Taiwanese population.	Bilirubin	148-157	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	114-120
26180834-6	2015	Discriminatory properties of UGT1A1 T/T genotype for predicting bilirubin-related atazanavir discontinuation through 96 weeks after antiretroviral initiation were estimated.	Bilirubin	64-73	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	29-35
26382171-3	2015	BHPF pretreatment significantly (p &lt; 0.001) inhibited the CCl4-induced increase in ALT, AST, ALP, LDH, total bilirubin, cholesterol, creatinine, uric acid, urea and malondialdehyde in a dose-dependent manner.	Bilirubin	112-121	chemokine (C-C motif) ligand 4	Mus musculus	61-65
26160631-1	2015	BACKGROUND: Heme oxygenase-1 (HO-1) is an inducible stress-responsive enzyme converting heme to bilirubin, carbon monoxide, and free iron, which exerts anti-inflammatory and antiapoptotic effects.	Bilirubin	96-105	heme oxygenase 1	Mus musculus	12-28
26160631-1	2015	BACKGROUND: Heme oxygenase-1 (HO-1) is an inducible stress-responsive enzyme converting heme to bilirubin, carbon monoxide, and free iron, which exerts anti-inflammatory and antiapoptotic effects.	Bilirubin	96-105	heme oxygenase 1	Mus musculus	30-34
26146841-3	2015	Eleven common mutations and polymorphisms across five bilirubin metabolism genes, namely those encoding UGT1A1, HMOX1, BLVRA, SLCO1B1 and SLCO1B3, were determined using the high resolution melt (HRM) assay or PCR-capillary electrophoresis analysis.	Bilirubin	54-63	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	104-110
26146841-3	2015	Eleven common mutations and polymorphisms across five bilirubin metabolism genes, namely those encoding UGT1A1, HMOX1, BLVRA, SLCO1B1 and SLCO1B3, were determined using the high resolution melt (HRM) assay or PCR-capillary electrophoresis analysis.	Bilirubin	54-63	heme oxygenase 1	Homo sapiens	112-117
25952649-2	2015	According to this model, hepatocytic bilirubin glucuronide can follow a liver-to-blood shuttling loop via Abcc3 transporter-mediated efflux and subsequent Oatp1a/1b-mediated liver uptake.	Bilirubin	37-46	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	106-111
26595496-2	2015	Heme oxygenase-1(HO-1) metabolizes heme into biliverdin, bilirubin, carbon monoxide, and iron, our recent study showed that serum level of HO-1 was increased in stroke patients, yet the association of HO-1 level with risk of intracerebral hemorrhage (ICH) is poorly known.	Bilirubin	57-66	heme oxygenase 1	Homo sapiens	0-16
26026212-11	2015	Future studies are needed to elucidate the causal associations of TB and GGT with CVD.	Bilirubin	66-68	gamma-glutamyltransferase light chain family member 3	Homo sapiens	73-76
26163808-0	2015	Bilirubin inhibits the up-regulation of inducible nitric oxide synthase by scavenging reactive oxygen species generated by the toll-like receptor 4-dependent activation of NADPH oxidase.	Bilirubin	0-9	toll-like receptor 4	Mus musculus	127-147
26163808-1	2015	It has been previously shown that bilirubin prevents the up-regulation of inducible nitric oxide synthase (iNOS) in response to LPS.	Bilirubin	34-43	nitric oxide synthase 2, inducible	Mus musculus	107-111
26163808-5	2015	While treatment with superoxide dismutase (SOD) and bilirubin effectively abolished LPS-mediated [Formula: see text] production, hydrogen peroxide and nitrate release were inhibited by bilirubin and PEG-catalase, but not SOD, supporting that iNOS activation is primarily dependent upon intracellular H2O2.	Bilirubin	52-61	nitric oxide synthase 2, inducible	Mus musculus	242-246
26163808-5	2015	While treatment with superoxide dismutase (SOD) and bilirubin effectively abolished LPS-mediated [Formula: see text] production, hydrogen peroxide and nitrate release were inhibited by bilirubin and PEG-catalase, but not SOD, supporting that iNOS activation is primarily dependent upon intracellular H2O2.	Bilirubin	185-194	nitric oxide synthase 2, inducible	Mus musculus	242-246
26163808-6	2015	LPS treatment increased nuclear translocation of the redox-sensitive transcription factor Hypoxia Inducible Factor-1alpha (HIF-1alpha), an effect that was abolished by bilirubin.	Bilirubin	168-177	hypoxia inducible factor 1, alpha subunit	Mus musculus	90-121
26163808-6	2015	LPS treatment increased nuclear translocation of the redox-sensitive transcription factor Hypoxia Inducible Factor-1alpha (HIF-1alpha), an effect that was abolished by bilirubin.	Bilirubin	168-177	hypoxia inducible factor 1, alpha subunit	Mus musculus	123-133
26163808-8	2015	Bilirubin, but not SOD, blocked the cellular production of interferon-beta, while interleukin-6 production remained unaffected.	Bilirubin	0-9	interferon beta 1, fibroblast	Mus musculus	59-74
26163808-9	2015	These data support that bilirubin inhibits the TLR4-mediated up-regulation of iNOS by preventing activation of HIF-1alpha through scavenging of Nox-derived reactive oxygen species.	Bilirubin	24-33	toll-like receptor 4	Mus musculus	47-51
26163808-9	2015	These data support that bilirubin inhibits the TLR4-mediated up-regulation of iNOS by preventing activation of HIF-1alpha through scavenging of Nox-derived reactive oxygen species.	Bilirubin	24-33	nitric oxide synthase 2, inducible	Mus musculus	78-82
26163808-9	2015	These data support that bilirubin inhibits the TLR4-mediated up-regulation of iNOS by preventing activation of HIF-1alpha through scavenging of Nox-derived reactive oxygen species.	Bilirubin	24-33	hypoxia inducible factor 1, alpha subunit	Mus musculus	111-121
26163808-10	2015	Bilirubin also suppresses interferon-beta release via a ROS-independent mechanism.	Bilirubin	0-9	interferon beta 1, fibroblast	Mus musculus	26-41
26186540-8	2015	An inverse correlation between IGF-1 and bilirubin serum levels at day 15 (r = -0.3924, p = 0.0320) and 30 (r = -0.3894, p = 0.0368) was found.	Bilirubin	41-50	insulin like growth factor 1	Homo sapiens	31-36
25820186-7	2015	CO and Fe were implicated in the HMOX1 effects, whereas bilirubin was inert or counteracted the HMOX1-related changes.	Bilirubin	56-65	heme oxygenase 1	Homo sapiens	96-101
25315738-3	2015	In patients with Rotor syndrome, bilirubin (re)uptake is impaired due to the deficiency of two basolateral/sinusoidal hepatocellular membrane proteins, organic anion-transporting polypeptide 1B1 (OATP1B1) and OATP1B3.	Bilirubin	33-42	solute carrier organic anion transporter family member 1B1	Homo sapiens	152-194
26089799-1	2015	Biliverdin reductase (BVR) is a multifunctional protein that is the primary source of the potent antioxidant, bilirubin.	Bilirubin	110-119	biliverdin reductase A	Homo sapiens	0-20
26089799-1	2015	Biliverdin reductase (BVR) is a multifunctional protein that is the primary source of the potent antioxidant, bilirubin.	Bilirubin	110-119	biliverdin reductase A	Homo sapiens	22-25
25315738-3	2015	In patients with Rotor syndrome, bilirubin (re)uptake is impaired due to the deficiency of two basolateral/sinusoidal hepatocellular membrane proteins, organic anion-transporting polypeptide 1B1 (OATP1B1) and OATP1B3.	Bilirubin	33-42	solute carrier organic anion transporter family member 1B1	Homo sapiens	196-203
25315738-3	2015	In patients with Rotor syndrome, bilirubin (re)uptake is impaired due to the deficiency of two basolateral/sinusoidal hepatocellular membrane proteins, organic anion-transporting polypeptide 1B1 (OATP1B1) and OATP1B3.	Bilirubin	33-42	solute carrier organic anion transporter family member 1B3	Homo sapiens	209-216
25315738-4	2015	Dubin-Johnson syndrome is caused by a defect in the ATP-dependent canalicular transporter, multidrug resistance-associated protein 2 (MRP2), which mediates the export of conjugated bilirubin into bile.	Bilirubin	181-190	ATP binding cassette subfamily C member 2	Homo sapiens	91-132
25315738-4	2015	Dubin-Johnson syndrome is caused by a defect in the ATP-dependent canalicular transporter, multidrug resistance-associated protein 2 (MRP2), which mediates the export of conjugated bilirubin into bile.	Bilirubin	181-190	ATP binding cassette subfamily C member 2	Homo sapiens	134-138
25315738-6	2015	Uridine diphospho-glucuronosyl transferase 1A1 (UGT1A1) is responsible for the glucuronidation of bilirubin; deficiency of this enzyme results in unconjugated hyperbilirubinaemia.	Bilirubin	98-107	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-46
25315738-6	2015	Uridine diphospho-glucuronosyl transferase 1A1 (UGT1A1) is responsible for the glucuronidation of bilirubin; deficiency of this enzyme results in unconjugated hyperbilirubinaemia.	Bilirubin	98-107	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	48-54
26039129-10	2015	Using an exome-wide approach we identified coding variants on UGT1A1 and UGT1A6 genes in association with serum bilirubin level and hyperbilirubinemia risk in elderly subjects.	Bilirubin	112-121	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	73-79
25782102-0	2015	Unconjugated bilirubin inhibits proteolytic cleavage of von Willebrand factor by ADAMTS13 protease.	Bilirubin	13-22	von Willebrand factor	Homo sapiens	56-77
25782102-0	2015	Unconjugated bilirubin inhibits proteolytic cleavage of von Willebrand factor by ADAMTS13 protease.	Bilirubin	13-22	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	81-89
25782102-3	2015	Previous studies have shown that unconjugated bilirubin lowers plasma ADAMTS13 activity, but the mechanism is not fully understood.	Bilirubin	46-55	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	70-78
25782102-4	2015	OBJECTIVES: The study is to determine whether unconjugated bilirubin directly inhibits the cleavage of von Willebrand factor (VWF) and its analogs by ADAMTS13.	Bilirubin	59-68	von Willebrand factor	Homo sapiens	103-124
25782102-4	2015	OBJECTIVES: The study is to determine whether unconjugated bilirubin directly inhibits the cleavage of von Willebrand factor (VWF) and its analogs by ADAMTS13.	Bilirubin	59-68	von Willebrand factor	Homo sapiens	126-129
25782102-4	2015	OBJECTIVES: The study is to determine whether unconjugated bilirubin directly inhibits the cleavage of von Willebrand factor (VWF) and its analogs by ADAMTS13.	Bilirubin	59-68	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	150-158
25782102-6	2015	RESULTS: Unconjugated bilirubin inhibits the cleavage of F485-rVWF73-H, D633-rVWF73-H, and GST-rVWF71-11K by ADAMTS13 in a concentration-dependent manner with a half-maximal inhibitory concentration of ~13, ~70, and ~17 mumol L(-1) , respectively.	Bilirubin	22-31	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	109-117
25782102-7	2015	Unconjugated bilirubin also dose-dependently inhibits the cleavage of multimeric VWF by ADAMTS13 under denaturing conditions.	Bilirubin	13-22	von Willebrand factor	Homo sapiens	81-84
25782102-7	2015	Unconjugated bilirubin also dose-dependently inhibits the cleavage of multimeric VWF by ADAMTS13 under denaturing conditions.	Bilirubin	13-22	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	88-96
25782102-8	2015	The inhibitory activity of bilirubin on the cleavage of D633-rVWF73-H and multimeric VWF, but not F485-rVWF73-H, was eliminated after incubation with bilirubin oxidase that converts bilirubin to biliverdin.	Bilirubin	27-36	von Willebrand factor	Homo sapiens	62-65
25782102-8	2015	The inhibitory activity of bilirubin on the cleavage of D633-rVWF73-H and multimeric VWF, but not F485-rVWF73-H, was eliminated after incubation with bilirubin oxidase that converts bilirubin to biliverdin.	Bilirubin	150-159	von Willebrand factor	Homo sapiens	62-65
25782102-10	2015	CONCLUSIONS: Unconjugated bilirubin directly inhibits ADAMTS13"s ability to cleave both peptidyl and native VWF substrates in addition to its interference with certain fluorogenic assays.	Bilirubin	26-35	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	54-62
25782102-10	2015	CONCLUSIONS: Unconjugated bilirubin directly inhibits ADAMTS13"s ability to cleave both peptidyl and native VWF substrates in addition to its interference with certain fluorogenic assays.	Bilirubin	26-35	von Willebrand factor	Homo sapiens	108-111
26039129-0	2015	Exome-Wide Association Study Identifies New Low-Frequency and Rare UGT1A1 Coding Variants and UGT1A6 Coding Variants Influencing Serum Bilirubin in Elderly Subjects: A Strobe Compliant Article.	Bilirubin	135-144	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	94-100
26039129-6	2015	These variants were in strong linkage disequilibrium with 3 intronic UGT1A1 variants (rs887829, rs4148325, rs6742078), which were significantly associated with total bilirubin level (P = 2.34 x 10(-34), P = 7.02 x 10(-34), and P = 8.27 x 10(-34)), as well as unconjugated, and conjugated bilirubin levels.	Bilirubin	166-175	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	69-75
25950469-0	2015	Impairment of enzymatic antioxidant defenses is associated with bilirubin-induced neuronal cell death in the cerebellum of Ugt1 KO mice.	Bilirubin	64-73	UDP glucuronosyltransferase 1 family, polypeptide A2	Mus musculus	123-127
26039129-6	2015	These variants were in strong linkage disequilibrium with 3 intronic UGT1A1 variants (rs887829, rs4148325, rs6742078), which were significantly associated with total bilirubin level (P = 2.34 x 10(-34), P = 7.02 x 10(-34), and P = 8.27 x 10(-34)), as well as unconjugated, and conjugated bilirubin levels.	Bilirubin	288-297	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	69-75
26039129-7	2015	We also identified UGT1A6 variants in association with total (rs6759892, p.Ser7Ala, P = 1.98 x 10(-26); rs2070959, p.Thr181Ala, P = 2.87 x 10(-27); and rs1105879, p.Arg184Ser, P = 3.27 x 10(-29)), unconjugated, and conjugated bilirubin levels.	Bilirubin	226-235	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	19-25
26039129-10	2015	Using an exome-wide approach we identified coding variants on UGT1A1 and UGT1A6 genes in association with serum bilirubin level and hyperbilirubinemia risk in elderly subjects.	Bilirubin	112-121	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	62-68
25993113-3	2015	In East Asian populations, the compound homozygous UGT1A1 G71R and Y486D variants are frequently observed in cases with bilirubin levels exceeding 200 mumol/L.	Bilirubin	120-129	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	51-57
25993113-8	2015	Therefore, we propose that the spectrum of UGT1A1 variations in CNS-II differs according to the bilirubin levels.	Bilirubin	96-105	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	43-49
25950469-6	2015	To identify protein changes associated with bilirubin-induced cell death, we performed proteomic analysis of cerebella from Ugt1 mutant and wild-type mice.	Bilirubin	44-53	UDP glucuronosyltransferase 1 family, polypeptide A2	Mus musculus	124-128
25770689-2	2015	Herein, we aimed to assess the relationship between serum total bilirubin level and severity of coronary artery disease (CAD) in association with the direct inflammatory marker such as C-reactive protein (CRP), the other indirect markers included in inflammation process such as neutrophil to lymphocyte ratio (NLR) and red cell distribution width (RDW) in patients with stable CAD.	Bilirubin	64-73	C-reactive protein	Homo sapiens	185-203
25770689-2	2015	Herein, we aimed to assess the relationship between serum total bilirubin level and severity of coronary artery disease (CAD) in association with the direct inflammatory marker such as C-reactive protein (CRP), the other indirect markers included in inflammation process such as neutrophil to lymphocyte ratio (NLR) and red cell distribution width (RDW) in patients with stable CAD.	Bilirubin	64-73	C-reactive protein	Homo sapiens	205-208
25770689-8	2015	Futhermore, there was a moderate and significant inverse correlation between serum total bilirubin level and the severity of CAD (r=-0.173, p&lt;0.001), CRP (r=-0.112, p&lt;0.001), NLR (r=-0.070, p=0.026) and RDW (r=-0.074, p=0.027).	Bilirubin	89-98	C-reactive protein	Homo sapiens	153-156
25770689-10	2015	In addition, total bilirubin level was inversely correlated with CRP, NLR and RDW.	Bilirubin	19-28	C-reactive protein	Homo sapiens	65-68
25716231-6	2015	In CHB and ACLF patients, serum levels of TGF-beta1 and IL-31 were both increased significantly compared with those in NC subjects and positively correlated with total bilirubin (TBil) and alpha-fetoprotein (AFP) levels.	Bilirubin	168-177	transforming growth factor beta 1	Homo sapiens	42-51
25716231-6	2015	In CHB and ACLF patients, serum levels of TGF-beta1 and IL-31 were both increased significantly compared with those in NC subjects and positively correlated with total bilirubin (TBil) and alpha-fetoprotein (AFP) levels.	Bilirubin	168-177	interleukin 31	Homo sapiens	56-61
25716231-6	2015	In CHB and ACLF patients, serum levels of TGF-beta1 and IL-31 were both increased significantly compared with those in NC subjects and positively correlated with total bilirubin (TBil) and alpha-fetoprotein (AFP) levels.	Bilirubin	179-183	transforming growth factor beta 1	Homo sapiens	42-51
25716231-6	2015	In CHB and ACLF patients, serum levels of TGF-beta1 and IL-31 were both increased significantly compared with those in NC subjects and positively correlated with total bilirubin (TBil) and alpha-fetoprotein (AFP) levels.	Bilirubin	179-183	interleukin 31	Homo sapiens	56-61
25984661-4	2015	The prognostic significance of all clinicopathologic factors was evaluated by univariate and multivariate analyses, and the performance of each factor in predicting overall survival (OS) and recurrence-free survival (RFS) was compared.High preoperative CA125, high TNM stage, and lymph node metastasis were independent risk predictors for OS and RFS in all patients and the 2 subgroups, but high CA19-9 was only significant when considering all patients and those with nonelevated bilirubin.	Bilirubin	481-490	mucin 16, cell surface associated	Homo sapiens	253-258
25475440-0	2015	Unconjugated bilirubin mediates heme oxygenase-1-induced vascular benefits in diabetic mice.	Bilirubin	13-22	heme oxygenase 1	Mus musculus	32-48
25475440-3	2015	We hypothesize that bilirubin mediates HO-1-induced vascular benefits in diabetes.	Bilirubin	20-29	heme oxygenase 1	Mus musculus	39-43
25475440-7	2015	Hemin treatment increased serum bilirubin, and ex vivo bilirubin treatment improved relaxations in diabetic mouse aortas, which was reversed by the Akt inhibitor.	Bilirubin	32-41	thymoma viral proto-oncogene 1	Mus musculus	148-151
25475440-7	2015	Hemin treatment increased serum bilirubin, and ex vivo bilirubin treatment improved relaxations in diabetic mouse aortas, which was reversed by the Akt inhibitor.	Bilirubin	55-64	thymoma viral proto-oncogene 1	Mus musculus	148-151
25475440-10	2015	Hemin and bilirubin reversed high glucose-induced reductions in Akt and eNOS phosphorylation and NO production.	Bilirubin	10-19	thymoma viral proto-oncogene 1	Mus musculus	64-67
25475440-13	2015	In summary, HO-1-induced restoration of endothelial function in diabetic mice is most likely mediated by bilirubin, which preserves NO bioavailability through the Akt/eNOS/NO cascade, suggesting bilirubin as a potential therapeutic target for clinical intervention of diabetic vasculopathy.	Bilirubin	105-114	heme oxygenase 1	Mus musculus	12-16
25475440-13	2015	In summary, HO-1-induced restoration of endothelial function in diabetic mice is most likely mediated by bilirubin, which preserves NO bioavailability through the Akt/eNOS/NO cascade, suggesting bilirubin as a potential therapeutic target for clinical intervention of diabetic vasculopathy.	Bilirubin	105-114	thymoma viral proto-oncogene 1	Mus musculus	163-166
25475440-13	2015	In summary, HO-1-induced restoration of endothelial function in diabetic mice is most likely mediated by bilirubin, which preserves NO bioavailability through the Akt/eNOS/NO cascade, suggesting bilirubin as a potential therapeutic target for clinical intervention of diabetic vasculopathy.	Bilirubin	195-204	heme oxygenase 1	Mus musculus	12-16
26191226-1	2015	AIM: Organic anion-transporting polypeptides OATP1B1 and OATP1B3 are sinusoidal membrane transporters mediating liver uptake of a wide range of substrates including conjugated and unconjugated bilirubin, xenobiotics and drugs.	Bilirubin	193-202	solute carrier organic anion transporter family member 1B1	Homo sapiens	45-52
26191226-1	2015	AIM: Organic anion-transporting polypeptides OATP1B1 and OATP1B3 are sinusoidal membrane transporters mediating liver uptake of a wide range of substrates including conjugated and unconjugated bilirubin, xenobiotics and drugs.	Bilirubin	193-202	solute carrier organic anion transporter family member 1B3	Homo sapiens	57-64
25246029-5	2015	RESULTS: We analyzed total bilirubin levels, which are linked to fatty liver in severe obesity, and observed the strongest evidence for association with rs4148325 in UGT1A (P &lt; 5.0 x 10(-93)), replicating previous findings.	Bilirubin	27-36	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	166-171
25966095-1	2015	Mutations in the UGT1A1 gene cause Crigler-Najjar syndrome (CN), which causes non-hemolytic unconjugated hyperbilirubinemia, and is categorized as CN1 and CN2 according to the severity of bilirubin levels.	Bilirubin	110-119	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	17-23
26401397-10	2015	)significantly reduces the CCl4 induced increase in level of serum SGPT, serum ALP and total bilirubin.	Bilirubin	93-102	C-C motif chemokine ligand 4	Rattus norvegicus	27-31
25581390-3	2015	In rats administered 20 and 80 mg/kg rifampicin, the plasma levels of bilirubin glucuronides were elevated, gradually decreased, and almost returned to the baseline level at 24 hours after administration without an elevation of alanine aminotransferase (ALT) and aspartate aminotransferase (AST).	Bilirubin	70-79	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	263-289
25581390-3	2015	In rats administered 20 and 80 mg/kg rifampicin, the plasma levels of bilirubin glucuronides were elevated, gradually decreased, and almost returned to the baseline level at 24 hours after administration without an elevation of alanine aminotransferase (ALT) and aspartate aminotransferase (AST).	Bilirubin	70-79	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	291-294
25482981-10	2015	The CD47mAb400-treated group showed lower serum transaminases, bilirubin, oxidative stress, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling staining, caspase-3 activity, and proinflammatory cytokine expression of tumor necrosis factor alpha, interleukin-1beta, and interleukin-6.	Bilirubin	63-72	CD47 molecule	Homo sapiens	4-14
25663682-7	2015	Haploinsufficiency at MLXIPL and increased penetrance for hypomorphic alleles at the UGT1A1 gene promoter might underlie the lipid and bilirubin alterations.	Bilirubin	135-144	MLX interacting protein like	Homo sapiens	22-28
25663682-7	2015	Haploinsufficiency at MLXIPL and increased penetrance for hypomorphic alleles at the UGT1A1 gene promoter might underlie the lipid and bilirubin alterations.	Bilirubin	135-144	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	85-91
25250558-11	2015	CONCLUSION: The Treg cells, mainly with memory phenotype and with high TNFRII expression, increased significantly in patients with liver cirrhosis and significantly correlated with the serum bilirubin levels.	Bilirubin	191-200	TNF receptor superfamily member 1B	Homo sapiens	71-77
26005382-0	2015	Correlation Between C-reactive Protein and Non-enzymatic Antioxidants (Albumin, Ferritin, Uric Acid and Bilirubin) in Hemodialysis Patients.	Bilirubin	104-113	C-reactive protein	Homo sapiens	20-38
26005382-12	2015	Furthermore, the positive, linear correlation was determined between serum CRP and ferritin (r = 0.159, p = 0.114) and positive linear correlation between CRP and total serum bilirubin (r = 0.121, p = 0.230).	Bilirubin	175-184	C-reactive protein	Homo sapiens	155-158
26223120-2	2015	OATP is involved in the transport of a variety of endo- and xenobiotics (bile acids, bilirubin, prostaglandin, thyroid hormones, steroid hormone conjugates), drugs and toxins in a Na+ and ATP independent manner.	Bilirubin	85-94	solute carrier organic anion transporter family member 1A2	Homo sapiens	0-4
25576848-2	2015	Gilbert"s Syndrome is associated with mutation in the Uridine Glucuronosyl Transferase 1A1 (UGT1A1) gene promoter, reducing UGT1A1 activity, which normally conjugates bilirubin allowing its elimination from the blood.	Bilirubin	167-176	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	54-90
25576848-2	2015	Gilbert"s Syndrome is associated with mutation in the Uridine Glucuronosyl Transferase 1A1 (UGT1A1) gene promoter, reducing UGT1A1 activity, which normally conjugates bilirubin allowing its elimination from the blood.	Bilirubin	167-176	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	92-98
25576848-2	2015	Gilbert"s Syndrome is associated with mutation in the Uridine Glucuronosyl Transferase 1A1 (UGT1A1) gene promoter, reducing UGT1A1 activity, which normally conjugates bilirubin allowing its elimination from the blood.	Bilirubin	167-176	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	124-130
24840069-6	2015	RESULTS: After removing of NTBC, fah(-/-) mice lost their body weight gradually, and finally died when the body weight largely reduced (low to 70%), along with increased serum ALT and total bilirubin.	Bilirubin	190-199	fumarylacetoacetate hydrolase	Mus musculus	33-36
25503851-7	2015	However, the other two by-products of HO1, bilirubin and Fe(2+), failed to induce AR formation.	Bilirubin	43-52	heme oxygenase 1, chloroplastic	Cucumis sativus	38-41
25420178-2	2015	BBC is not synonymous with albumin (Alb) levels because Alb binding of bilirubin is confounded by a variety of molecular, biologic, and metabolic factors.	Bilirubin	71-80	albumin	Homo sapiens	56-59
25744452-1	2015	Heme oxygenase-1 (HO-1) catabolizes the degradation of heme into bilirubin, carbon monoxide, and iron ions.	Bilirubin	65-74	heme oxygenase 1	Homo sapiens	0-16
25744452-1	2015	Heme oxygenase-1 (HO-1) catabolizes the degradation of heme into bilirubin, carbon monoxide, and iron ions.	Bilirubin	65-74	heme oxygenase 1	Homo sapiens	18-22
26159150-7	2015	Intriguingly, pharmacological inactivation of HO-1 with zinc protoporphyrin IX reversed anti-inflammatory effect of ZY- 1A4, but the anti-inflammatory effect of ZY-1A4 was largely mimicked by HO-1 by-products carbon monoxide and bilirubin.	Bilirubin	229-238	heme oxygenase 1	Homo sapiens	46-50
26159150-7	2015	Intriguingly, pharmacological inactivation of HO-1 with zinc protoporphyrin IX reversed anti-inflammatory effect of ZY- 1A4, but the anti-inflammatory effect of ZY-1A4 was largely mimicked by HO-1 by-products carbon monoxide and bilirubin.	Bilirubin	229-238	heme oxygenase 1	Homo sapiens	192-196
25462643-0	2015	Identification of heme oxygenase-1 stimulators by a convenient ELISA-based bilirubin quantification assay.	Bilirubin	75-84	heme oxygenase 1	Mus musculus	18-34
25462643-5	2015	The quantification of HO-1 activity is based on an indirect ELISA using the specific anti-bilirubin antibody 24G7 to quantify directly bilirubin in the whole cell lysate, applying a horseradish peroxidase-tagged antibody together with ortho-phenylenediamine and H2O2 for detection.	Bilirubin	90-99	heme oxygenase 1	Mus musculus	22-26
25462643-5	2015	The quantification of HO-1 activity is based on an indirect ELISA using the specific anti-bilirubin antibody 24G7 to quantify directly bilirubin in the whole cell lysate, applying a horseradish peroxidase-tagged antibody together with ortho-phenylenediamine and H2O2 for detection.	Bilirubin	135-144	heme oxygenase 1	Mus musculus	22-26
26466645-10	2015	RESULTS: Ses decreased the release of liver enzymes - ALT, AST, and TBIL, reduced protein carbonyls, attenuated the reduction of SOD and GSH-Px activities induced by CCl4 in the liver tissue.	Bilirubin	68-72	C-C motif chemokine ligand 4	Rattus norvegicus	166-170
26191391-9	2015	Pump time, alanine aminotransferase in third postoperative day and direct bilirubin in first and second day of postoperative period had significant relation with pre and post-operative bilirubin change.	Bilirubin	185-194	glutamic--pyruvic transaminase	Homo sapiens	11-35
26517138-8	2015	The level of bilirubin among patients with different genotypes of UGT1A6 was significantly different (p-value &amp;lt; 0.05).	Bilirubin	13-22	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	66-72
25323532-11	2015	Serum IL-17 levels were positively correlated with total bilirubin (TBIL), alanine aminotransferase (ALT) and Child-Pugh grade, and were negatively correlated with albumin.	Bilirubin	68-72	interleukin 17A	Homo sapiens	6-11
26681075-9	2015	BIL administration significantly decreased plasma levels of C-reactive protein and ceruloplasmin in the AIA-BIL group in comparison to the AIA group.	Bilirubin	0-3	C-reactive protein	Rattus norvegicus	60-78
26681075-9	2015	BIL administration significantly decreased plasma levels of C-reactive protein and ceruloplasmin in the AIA-BIL group in comparison to the AIA group.	Bilirubin	0-3	ceruloplasmin	Rattus norvegicus	83-96
26681075-9	2015	BIL administration significantly decreased plasma levels of C-reactive protein and ceruloplasmin in the AIA-BIL group in comparison to the AIA group.	Bilirubin	108-111	C-reactive protein	Rattus norvegicus	60-78
26681075-9	2015	BIL administration significantly decreased plasma levels of C-reactive protein and ceruloplasmin in the AIA-BIL group in comparison to the AIA group.	Bilirubin	108-111	ceruloplasmin	Rattus norvegicus	83-96
25478736-2	2015	We have recently described a concerted intracellular BR regulation by two microsomal enzymes: heme oxygenase 1 (HMOX1), essential for BR production and cytochrome P450 2A5 (CYP2A5), a BR oxidase.	Bilirubin	53-55	heme oxygenase 1	Mus musculus	94-110
25478736-2	2015	We have recently described a concerted intracellular BR regulation by two microsomal enzymes: heme oxygenase 1 (HMOX1), essential for BR production and cytochrome P450 2A5 (CYP2A5), a BR oxidase.	Bilirubin	53-55	heme oxygenase 1	Mus musculus	112-117
25478736-2	2015	We have recently described a concerted intracellular BR regulation by two microsomal enzymes: heme oxygenase 1 (HMOX1), essential for BR production and cytochrome P450 2A5 (CYP2A5), a BR oxidase.	Bilirubin	53-55	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	152-171
25478736-2	2015	We have recently described a concerted intracellular BR regulation by two microsomal enzymes: heme oxygenase 1 (HMOX1), essential for BR production and cytochrome P450 2A5 (CYP2A5), a BR oxidase.	Bilirubin	53-55	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	173-179
25478736-2	2015	We have recently described a concerted intracellular BR regulation by two microsomal enzymes: heme oxygenase 1 (HMOX1), essential for BR production and cytochrome P450 2A5 (CYP2A5), a BR oxidase.	Bilirubin	134-136	heme oxygenase 1	Mus musculus	94-110
25478736-2	2015	We have recently described a concerted intracellular BR regulation by two microsomal enzymes: heme oxygenase 1 (HMOX1), essential for BR production and cytochrome P450 2A5 (CYP2A5), a BR oxidase.	Bilirubin	134-136	heme oxygenase 1	Mus musculus	112-117
25478736-2	2015	We have recently described a concerted intracellular BR regulation by two microsomal enzymes: heme oxygenase 1 (HMOX1), essential for BR production and cytochrome P450 2A5 (CYP2A5), a BR oxidase.	Bilirubin	134-136	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	173-179
25478736-9	2015	An adrenodoxin reductase antibody did not inhibit microsomal BR oxidation but inhibited 50% of mitochondrial BR oxidation.	Bilirubin	109-111	ferredoxin reductase	Mus musculus	3-24
25478736-12	2015	Bilirubin affinity to mitochondrial and microsomal CYP2A5 enzyme is equally high.	Bilirubin	0-9	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	51-57
25478736-14	2015	Collectively, the observations suggest that BR regulatory enzymes are recruited to mitochondria during oxidative stress and BR oxidation by mitochondrial CYP2A5 is supported by mitochondrial mono-oxygenase system.	Bilirubin	44-46	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	154-160
25478736-14	2015	Collectively, the observations suggest that BR regulatory enzymes are recruited to mitochondria during oxidative stress and BR oxidation by mitochondrial CYP2A5 is supported by mitochondrial mono-oxygenase system.	Bilirubin	124-126	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	154-160
24832180-10	2014	In patients with large tumors, the elevated AFP was associated with significantly higher GGTP, ALKP, and bilirubin levels, as well as with increased PVT and multifocality, and worse survival.	Bilirubin	105-114	alpha fetoprotein	Homo sapiens	44-47
25086287-2	2014	The enzyme uridine diphosphate glucuronosyltransferase polypeptide 1A1 (UGT1A1) is solely responsible for clearing bilirubin from the blood and homozygosity for seven thymine-adenine (TA) repeats in the TATA box regulatory element of the UGT1A1 gene underlies a mild hereditary unconjugated hyperbilirubinaemia (Gilbert"s syndrome).	Bilirubin	115-124	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	11-70
25086287-2	2014	The enzyme uridine diphosphate glucuronosyltransferase polypeptide 1A1 (UGT1A1) is solely responsible for clearing bilirubin from the blood and homozygosity for seven thymine-adenine (TA) repeats in the TATA box regulatory element of the UGT1A1 gene underlies a mild hereditary unconjugated hyperbilirubinaemia (Gilbert"s syndrome).	Bilirubin	115-124	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	72-78
25086287-2	2014	The enzyme uridine diphosphate glucuronosyltransferase polypeptide 1A1 (UGT1A1) is solely responsible for clearing bilirubin from the blood and homozygosity for seven thymine-adenine (TA) repeats in the TATA box regulatory element of the UGT1A1 gene underlies a mild hereditary unconjugated hyperbilirubinaemia (Gilbert"s syndrome).	Bilirubin	115-124	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	238-244
25200497-9	2014	Quantitative analysis showed that sense mutation (including UGT1A1*6) and UGT1A1*28/*28, but not UGT1A1*60/*60 or UGT1A1*1/*28, was associated with increased serum total bilirubin (TB) levels.	Bilirubin	170-179	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	60-66
25200497-9	2014	Quantitative analysis showed that sense mutation (including UGT1A1*6) and UGT1A1*28/*28, but not UGT1A1*60/*60 or UGT1A1*1/*28, was associated with increased serum total bilirubin (TB) levels.	Bilirubin	170-179	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	74-80
25200497-9	2014	Quantitative analysis showed that sense mutation (including UGT1A1*6) and UGT1A1*28/*28, but not UGT1A1*60/*60 or UGT1A1*1/*28, was associated with increased serum total bilirubin (TB) levels.	Bilirubin	170-179	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	74-80
25200497-9	2014	Quantitative analysis showed that sense mutation (including UGT1A1*6) and UGT1A1*28/*28, but not UGT1A1*60/*60 or UGT1A1*1/*28, was associated with increased serum total bilirubin (TB) levels.	Bilirubin	170-179	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	74-80
25200497-9	2014	Quantitative analysis showed that sense mutation (including UGT1A1*6) and UGT1A1*28/*28, but not UGT1A1*60/*60 or UGT1A1*1/*28, was associated with increased serum total bilirubin (TB) levels.	Bilirubin	181-183	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	60-66
25200497-9	2014	Quantitative analysis showed that sense mutation (including UGT1A1*6) and UGT1A1*28/*28, but not UGT1A1*60/*60 or UGT1A1*1/*28, was associated with increased serum total bilirubin (TB) levels.	Bilirubin	181-183	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	74-80
25200497-9	2014	Quantitative analysis showed that sense mutation (including UGT1A1*6) and UGT1A1*28/*28, but not UGT1A1*60/*60 or UGT1A1*1/*28, was associated with increased serum total bilirubin (TB) levels.	Bilirubin	181-183	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	74-80
25200497-9	2014	Quantitative analysis showed that sense mutation (including UGT1A1*6) and UGT1A1*28/*28, but not UGT1A1*60/*60 or UGT1A1*1/*28, was associated with increased serum total bilirubin (TB) levels.	Bilirubin	181-183	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	74-80
25200497-11	2014	CONCLUSIONS: This study identified four novel UGT1A1 coding variants, some of which were associated with increased serum TB levels.	Bilirubin	121-123	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	46-52
25394069-1	2014	INTRODUCTION: We have previously shown in the SSAT 044 study that unconjugated hyperbilirubinaemia in subjects receiving a boosted protease inhibitor (PI/r) has limited impact on renal, cardiovascular (CV) and bone biomarkers, as well as on neurocognitive performance, relative to those receiving PI/r with a normal bilirubin.	Bilirubin	84-93	serpin family A member 13, pseudogene	Homo sapiens	131-149
25394086-4	2014	ATV contributes to the decreased levels of UGT1A1, which may lead to elevations of indirect bilirubin, jaundice and even to therapy discontinuation.	Bilirubin	92-101	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	43-49
25149194-6	2014	Multivariable linear regression analyses demonstrated that in all subjects combined total cholesterol, non-HDL cholesterol, triglycerides and apoE were negatively associated with bilirubin after adjustment for age, sex, T2DM, body mass index and alanine aminotransferase (all p&lt;0.05).	Bilirubin	179-188	apolipoprotein E	Homo sapiens	142-146
25262077-1	2014	BACKGROUND: Gilbert syndrome (GS) is an inherited defect of bilirubin conjugation, most commonly caused by a gene mutation for the enzyme UGT1A.	Bilirubin	60-69	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	138-143
25204339-8	2014	Overall, the reversible, unconjugated hyperbilirubinemia associated with faldaprevir may predominantly result from inhibition of bilirubin conjugation by UGT1A1, with inhibition of hepatic uptake of bilirubin also potentially playing a role.	Bilirubin	43-52	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	154-160
25204339-8	2014	Overall, the reversible, unconjugated hyperbilirubinemia associated with faldaprevir may predominantly result from inhibition of bilirubin conjugation by UGT1A1, with inhibition of hepatic uptake of bilirubin also potentially playing a role.	Bilirubin	129-138	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	154-160
25204339-9	2014	Since OATP1B1/1B3 are known to be involved in hepatic uptake of circulating bilirubin glucuronides, inhibition of OATP1B1/1B3 and MRP2 may underlie isolated increases in conjugated bilirubin.	Bilirubin	76-85	solute carrier organic anion transporter family member 1B1	Homo sapiens	6-17
25204339-9	2014	Since OATP1B1/1B3 are known to be involved in hepatic uptake of circulating bilirubin glucuronides, inhibition of OATP1B1/1B3 and MRP2 may underlie isolated increases in conjugated bilirubin.	Bilirubin	181-190	solute carrier organic anion transporter family member 1B1	Homo sapiens	114-125
25204339-9	2014	Since OATP1B1/1B3 are known to be involved in hepatic uptake of circulating bilirubin glucuronides, inhibition of OATP1B1/1B3 and MRP2 may underlie isolated increases in conjugated bilirubin.	Bilirubin	181-190	ATP binding cassette subfamily C member 2	Homo sapiens	130-134
25105254-2	2014	Bilirubin is a potent endogenous antioxidant, and the UGT1A1*28 polymorphism is the main genetic cause of variation in plasma bilirubin in Western Europe.	Bilirubin	126-135	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	54-60
23160382-5	2014	CCl4-treated rats caused a significant increase in serum enzyme levels, such as aspartate aminotransferase, alanine aminotransferase and total bilirubin, and decrease in albumin, when compared with control.	Bilirubin	143-152	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
25406570-3	2014	It is encoded by the gene of solute carrier organic anion transporter family member 1B1 and the gene variants that inhibit hepatic bilirubin uptake function may reduce the normal functional level of bilirubin elimination and result in neonatal hyperbilirubinemia.	Bilirubin	131-140	solute carrier organic anion transporter family member 1B1	Homo sapiens	29-87
25406570-3	2014	It is encoded by the gene of solute carrier organic anion transporter family member 1B1 and the gene variants that inhibit hepatic bilirubin uptake function may reduce the normal functional level of bilirubin elimination and result in neonatal hyperbilirubinemia.	Bilirubin	199-208	solute carrier organic anion transporter family member 1B1	Homo sapiens	29-87
25319636-0	2014	Crigler-Najjar syndrome type II in a Chinese boy resulting from three mutations in the bilirubin uridine 5"-diphosphate-glucuronosyltransferase (UGT1A1) gene and a family genetic analysis.	Bilirubin	87-96	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	145-151
25319636-1	2014	BACKGROUND: The UGT1A1 gene encodes a responsible enzyme, UDP-glucuronosyltransferase1A1 (UGT1A1), for bilirubin metabolism.	Bilirubin	103-112	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	16-22
25319636-1	2014	BACKGROUND: The UGT1A1 gene encodes a responsible enzyme, UDP-glucuronosyltransferase1A1 (UGT1A1), for bilirubin metabolism.	Bilirubin	103-112	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	58-88
25319636-1	2014	BACKGROUND: The UGT1A1 gene encodes a responsible enzyme, UDP-glucuronosyltransferase1A1 (UGT1A1), for bilirubin metabolism.	Bilirubin	103-112	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	90-96
25299316-5	2014	RESULTS: The serum TB concentration was negatively correlated with the duration of diabetes, HbA1c, the 10-year Framingham risk score, and baPWV and was positively correlated with high-density lipoprotein cholesterol and the eGFR in both genders.	Bilirubin	19-21	epidermal growth factor receptor	Homo sapiens	225-229
23834361-8	2014	In the evaluation of the relationship between miRNA expression and clinical test parameters, significant and positive correlations were found for miR-299-5p with alkaline phosphatase, gamma-glutamyl transpeptidase, total bilirubin and immunoglobulin M levels.	Bilirubin	221-230	microRNA 299	Homo sapiens	146-153
25246627-11	2014	However, G6PD-deficient and -intermediate infants had higher declines in hematocrit, bilirubin levels, and need for phototherapy than G6PD-normal infants (P &lt; .001).	Bilirubin	85-94	glucose-6-phosphate dehydrogenase	Homo sapiens	9-13
25336012-6	2014	ABCC2 may excrete diglucuronosyl bilirubin preferentially over monoglucuronosyl bilirubin.	Bilirubin	33-42	ATP binding cassette subfamily C member 2	Homo sapiens	0-5
25336012-6	2014	ABCC2 may excrete diglucuronosyl bilirubin preferentially over monoglucuronosyl bilirubin.	Bilirubin	80-89	ATP binding cassette subfamily C member 2	Homo sapiens	0-5
25317020-9	2014	In conclusion, bilirubin attenuates renal dysfunction and dyslipidemia in diabetes by suppressing LXRalpha and SREBP-1 expression and oxidative stress.	Bilirubin	15-24	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	98-106
25317020-9	2014	In conclusion, bilirubin attenuates renal dysfunction and dyslipidemia in diabetes by suppressing LXRalpha and SREBP-1 expression and oxidative stress.	Bilirubin	15-24	sterol regulatory element binding transcription factor 1	Rattus norvegicus	111-118
25092941-3	2014	UGT1A1 is the rate-limiting enzyme in bilirubin"s metabolism.	Bilirubin	38-47	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
25228180-8	2014	Moreover, CCl4 damage results in an obvious increase of serum triglycerides, high-density lipoprotein, low-density lipoprotein, malondialdehyde, total bilirubin, alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase activity.	Bilirubin	151-160	C-C motif chemokine ligand 4	Rattus norvegicus	10-14
24929286-5	2014	RESULTS: In all subjects combined, bilirubin was positively related to adiponectin (r = 0.205, P = 0.006).	Bilirubin	35-44	adiponectin, C1Q and collagen domain containing	Homo sapiens	71-82
24929286-9	2014	CONCLUSION: Bilirubin is related to adiponectin, but the association of bilirubin with CVD risk is largely unaffected by adiponectin.	Bilirubin	12-21	adiponectin, C1Q and collagen domain containing	Homo sapiens	36-47
24677717-7	2014	Bilirubin was inversely associated with the renal end point in RENAAL independent of age, sex, race, BMI, smoking, total cholesterol, diastolic blood pressure, HbA1c, treatment, estimated glomerular filtration rate, albumin-to-creatinine ratio, and AST.	Bilirubin	0-9	solute carrier family 17 member 5	Homo sapiens	249-252
24837423-3	2014	The hypothesis of a system is supported by (i) coordinate regulation of subsets of these enzyme families and transporters by transcription factors including the AhR, and (ii) feedback loops between endobiotic AhR agonists and substrates of major catabolic target genes/proteins; for example, 6-formylindolo[3,2-b]carbazole as substrate of CYP1A1, and bilirubin, as substrate of UGT1A1.	Bilirubin	351-360	aryl hydrocarbon receptor	Homo sapiens	161-164
24837423-3	2014	The hypothesis of a system is supported by (i) coordinate regulation of subsets of these enzyme families and transporters by transcription factors including the AhR, and (ii) feedback loops between endobiotic AhR agonists and substrates of major catabolic target genes/proteins; for example, 6-formylindolo[3,2-b]carbazole as substrate of CYP1A1, and bilirubin, as substrate of UGT1A1.	Bilirubin	351-360	aryl hydrocarbon receptor	Homo sapiens	209-212
24837423-3	2014	The hypothesis of a system is supported by (i) coordinate regulation of subsets of these enzyme families and transporters by transcription factors including the AhR, and (ii) feedback loops between endobiotic AhR agonists and substrates of major catabolic target genes/proteins; for example, 6-formylindolo[3,2-b]carbazole as substrate of CYP1A1, and bilirubin, as substrate of UGT1A1.	Bilirubin	351-360	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	339-345
24837423-3	2014	The hypothesis of a system is supported by (i) coordinate regulation of subsets of these enzyme families and transporters by transcription factors including the AhR, and (ii) feedback loops between endobiotic AhR agonists and substrates of major catabolic target genes/proteins; for example, 6-formylindolo[3,2-b]carbazole as substrate of CYP1A1, and bilirubin, as substrate of UGT1A1.	Bilirubin	351-360	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	378-384
24837423-4	2014	In the latter case the AhR is one of multiple transcription factors contributing to bilirubin homeostasis.	Bilirubin	84-93	aryl hydrocarbon receptor	Homo sapiens	23-26
24650397-2	2014	STUDY DESIGN: UGT1A1 gene allelic variation was analyzed in 170 Japanese infants with BMJ with polymerase chain reaction-direct sequencing, and their genotypes compared with serum bilirubin concentrations.	Bilirubin	180-189	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	14-20
24728488-8	2014	In particular, UGT1A1, UGT1A7, and UGT1B1 displayed good glucuronidation activities toward most phenolic aglycones (4-methylumbelliferone, 4-nitrophenol, 1-naphthol, bisphenol A, and mycophenolic acid) and the two carboxylic acids (bilirubin and diclofenac).	Bilirubin	232-241	UDP-glucuronosyltransferase 1-1	Danio rerio	15-21
24728488-8	2014	In particular, UGT1A1, UGT1A7, and UGT1B1 displayed good glucuronidation activities toward most phenolic aglycones (4-methylumbelliferone, 4-nitrophenol, 1-naphthol, bisphenol A, and mycophenolic acid) and the two carboxylic acids (bilirubin and diclofenac).	Bilirubin	232-241	UDP glucuronosyltransferase 1 family, polypeptide A7	Danio rerio	23-29
24728488-8	2014	In particular, UGT1A1, UGT1A7, and UGT1B1 displayed good glucuronidation activities toward most phenolic aglycones (4-methylumbelliferone, 4-nitrophenol, 1-naphthol, bisphenol A, and mycophenolic acid) and the two carboxylic acids (bilirubin and diclofenac).	Bilirubin	232-241	UDP glucuronosyltransferase 1 family, polypeptide B1	Danio rerio	35-41
25008873-16	2014	CONCLUSIONS: For preterm infants, eHF can improve gastrointestinal motility, accelerate bilirubin metabolism and excretion and does not increase the incidence of EUGR.	Bilirubin	88-97	ETS homologous factor	Homo sapiens	34-37
24792516-0	2014	Post-transcriptional regulation by miR-137 underlies the low abundance of CAR and low rate of bilirubin clearance in neonatal mice.	Bilirubin	94-103	microRNA 137	Mus musculus	35-42
24792516-9	2014	Knockdown of endogenous miR-137 by its inhibitor increased the rate of bilirubin clearance in OJ mice.	Bilirubin	71-80	microRNA 137	Mus musculus	24-31
24792516-11	2014	SIGNIFICANCE: Our findings indicate that miR-137 is a repressor of CAR and thus a critical determinant of bilirubin clearance and may be considered a molecular target for the treatment of neonatal hyperbilirubinemia.	Bilirubin	106-115	microRNA 137	Mus musculus	41-48
24792516-11	2014	SIGNIFICANCE: Our findings indicate that miR-137 is a repressor of CAR and thus a critical determinant of bilirubin clearance and may be considered a molecular target for the treatment of neonatal hyperbilirubinemia.	Bilirubin	106-115	nuclear receptor subfamily 1, group I, member 3	Mus musculus	67-70
24903748-11	2014	Unconjugated bilirubin correlated with haemoglobin, which was inversely correlated with CRP.	Bilirubin	13-22	C-reactive protein	Homo sapiens	88-91
24903748-12	2014	CONCLUSIONS: The changes of bilirubin and liver enzymes during ischemic stroke reflect two phenomena, which are both related to IV: 1) inflammation, with consequent increment of CRP, leukocytes and gammaGT, and decrease of haemoglobin and unconjugated bilirubin and 2) an unknown signal, independent from inflammation, leading to increasing GOT and GPT levels.	Bilirubin	28-37	glutamic--pyruvic transaminase	Homo sapiens	349-352
24901842-2	2014	The UGT1A1*28 polymorphism (TA repeats in the promoter region) is a major determinant of bilirubin levels and recent evidence suggests that raised adiposity may also be a contributing factor.	Bilirubin	89-98	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	4-10
24901842-3	2014	We aimed to study the interaction between UGT1A1 polymorphism, hematological and anthropometric variables with total bilirubin levels in young individuals.	Bilirubin	117-126	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	42-48
24901842-12	2014	UGT1A1 polymorphism and body fat percentage were the main factors affecting bilirubin levels within obese patients (linear regression analysis).	Bilirubin	76-85	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
24901842-13	2014	CONCLUSION: In obese children and adolescents, body fat composition and UGT1A1 polymorphism are independent determinants of total bilirubin levels.	Bilirubin	130-139	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	72-78
24418412-1	2014	In haem degradation, haem oxygenase-1 (HO-1) first cleaves haem to biliverdin, which is reduced to bilirubin by biliverdin IXalpha reductase (BVR-A).	Bilirubin	99-108	heme oxygenase 1	Rattus norvegicus	21-37
24418412-1	2014	In haem degradation, haem oxygenase-1 (HO-1) first cleaves haem to biliverdin, which is reduced to bilirubin by biliverdin IXalpha reductase (BVR-A).	Bilirubin	99-108	heme oxygenase 1	Rattus norvegicus	39-43
24418412-1	2014	In haem degradation, haem oxygenase-1 (HO-1) first cleaves haem to biliverdin, which is reduced to bilirubin by biliverdin IXalpha reductase (BVR-A).	Bilirubin	99-108	biliverdin reductase A	Rattus norvegicus	112-140
24418412-1	2014	In haem degradation, haem oxygenase-1 (HO-1) first cleaves haem to biliverdin, which is reduced to bilirubin by biliverdin IXalpha reductase (BVR-A).	Bilirubin	99-108	biliverdin reductase A	Rattus norvegicus	142-147
24977002-1	2014	BACKGROUND: There is a reverse relationship between serum bilirubin level and incidence of stroke, heme oxygenase-1 (HO-1) can catalyze heme into bilirubin, it is unknown the association of HO-1 level with risk of stroke.	Bilirubin	146-155	heme oxygenase 1	Homo sapiens	99-115
24977002-1	2014	BACKGROUND: There is a reverse relationship between serum bilirubin level and incidence of stroke, heme oxygenase-1 (HO-1) can catalyze heme into bilirubin, it is unknown the association of HO-1 level with risk of stroke.	Bilirubin	146-155	heme oxygenase 1	Homo sapiens	117-121
24789201-1	2014	The constitutive active/androstane receptor (CAR) plays an important role as a coordinate transcription factor in the regulation of various hepatic metabolic pathways for chemicals such as drugs, glucose, fatty acids, bilirubin, and bile acids.	Bilirubin	218-227	nuclear receptor subfamily 1 group I member 3	Homo sapiens	4-43
24789201-1	2014	The constitutive active/androstane receptor (CAR) plays an important role as a coordinate transcription factor in the regulation of various hepatic metabolic pathways for chemicals such as drugs, glucose, fatty acids, bilirubin, and bile acids.	Bilirubin	218-227	nuclear receptor subfamily 1 group I member 3	Homo sapiens	45-48
24549402-9	2014	Serum IL-35, IL-6 and IL-17 levels were positively correlated with total bilirubin and international normalized ratio, and negatively correlated with albumin.	Bilirubin	73-82	interleukin 6	Homo sapiens	13-17
24549402-9	2014	Serum IL-35, IL-6 and IL-17 levels were positively correlated with total bilirubin and international normalized ratio, and negatively correlated with albumin.	Bilirubin	73-82	interleukin 17A	Homo sapiens	22-27
24236690-7	2014	In addition, the TGF-beta1/IL-17 ratio was also markedly increased in patients with HBV-LC, especially in nonsurvival and decompensated liver cirrhosis patients, and positively correlated with total bilirubin, Child-Pugh, and model of end-stage liver disease scores.	Bilirubin	199-208	transforming growth factor beta 1	Homo sapiens	17-26
24236690-7	2014	In addition, the TGF-beta1/IL-17 ratio was also markedly increased in patients with HBV-LC, especially in nonsurvival and decompensated liver cirrhosis patients, and positively correlated with total bilirubin, Child-Pugh, and model of end-stage liver disease scores.	Bilirubin	199-208	interleukin 17A	Homo sapiens	27-32
29764065-4	2014	RESULTS: Suggestive relationships have been established between lipid plasma levels and total bilirubin and SNPs in CETP, MCP1, ABCC2, LEP and SLCO1B3 genes and between diarrhea and SNPs in IL6 gene.	Bilirubin	94-103	cholesteryl ester transfer protein	Homo sapiens	116-120
29764065-4	2014	RESULTS: Suggestive relationships have been established between lipid plasma levels and total bilirubin and SNPs in CETP, MCP1, ABCC2, LEP and SLCO1B3 genes and between diarrhea and SNPs in IL6 gene.	Bilirubin	94-103	C-C motif chemokine ligand 2	Homo sapiens	122-126
29764065-4	2014	RESULTS: Suggestive relationships have been established between lipid plasma levels and total bilirubin and SNPs in CETP, MCP1, ABCC2, LEP and SLCO1B3 genes and between diarrhea and SNPs in IL6 gene.	Bilirubin	94-103	ATP binding cassette subfamily C member 2	Homo sapiens	128-133
29764065-4	2014	RESULTS: Suggestive relationships have been established between lipid plasma levels and total bilirubin and SNPs in CETP, MCP1, ABCC2, LEP and SLCO1B3 genes and between diarrhea and SNPs in IL6 gene.	Bilirubin	94-103	leptin	Homo sapiens	135-138
24131232-1	2014	SIGNIFICANCE: Heme oxygenases (HO-1 and HO-2) catalyze the degradation of the pro-oxidant heme into carbon monoxide (CO), iron, and biliverdin, which is subsequently converted to bilirubin.	Bilirubin	179-188	heme oxygenase 1	Homo sapiens	31-35
24131232-1	2014	SIGNIFICANCE: Heme oxygenases (HO-1 and HO-2) catalyze the degradation of the pro-oxidant heme into carbon monoxide (CO), iron, and biliverdin, which is subsequently converted to bilirubin.	Bilirubin	179-188	heme oxygenase 2	Homo sapiens	40-44
24131232-5	2014	Moreover, therapeutic delivery of HO-1 products CO, biliverdin, and bilirubin has been shown to have favorable effects, notably on endothelial cells and in animal models of vascular disease.	Bilirubin	68-77	heme oxygenase 1	Homo sapiens	34-38
24503768-6	2014	IL-12 serum levels decreased, whereas alanine transaminase and total bilirubin slightly increased in rats infused with IL-10-TGF-beta1-imDC compared with the IL-10-imDC and TGF-beta1-imDC groups.	Bilirubin	69-78	interleukin 10	Rattus norvegicus	119-124
24503768-6	2014	IL-12 serum levels decreased, whereas alanine transaminase and total bilirubin slightly increased in rats infused with IL-10-TGF-beta1-imDC compared with the IL-10-imDC and TGF-beta1-imDC groups.	Bilirubin	69-78	transforming growth factor, beta 1	Rattus norvegicus	125-134
24442509-7	2014	CONCLUSIONS/INTERPRETATION: The minor rs1183910 A allele prompts a potential adverse metabolic profile with increased levels of non-fasting glucose, total cholesterol, LDL-cholesterol, ApoB, and alkaline phosphatase, but simultaneously has potential beneficial effects through decreased levels of CRP, gamma-glutamyltransferase and bilirubin.	Bilirubin	332-341	C-reactive protein	Homo sapiens	297-300
25371888-6	2014	In addition, the HO-1 inducer cobalt protoporphyrin (CoPP) and the metabolic product of HO-1 bilirubin mimicked diazoxide to inhibit sFlt-1 release and reactive oxygen species (ROS) production under hypoxia, whereas the HO-1 inhibitor zinc protoporphyrin IX (ZnPP IX) antagonized the effect of diazoxide.	Bilirubin	93-102	heme oxygenase 1	Homo sapiens	88-92
25371888-6	2014	In addition, the HO-1 inducer cobalt protoporphyrin (CoPP) and the metabolic product of HO-1 bilirubin mimicked diazoxide to inhibit sFlt-1 release and reactive oxygen species (ROS) production under hypoxia, whereas the HO-1 inhibitor zinc protoporphyrin IX (ZnPP IX) antagonized the effect of diazoxide.	Bilirubin	93-102	heme oxygenase 1	Homo sapiens	88-92
24460025-11	2014	G6PD activity showed statistically significant correlation with total bilirubin blood levels.	Bilirubin	70-79	glucose-6-phosphate dehydrogenase	Homo sapiens	0-4
23996546-5	2014	The bergenin glucuronosyltransferase activities in HLMs and UGT1A1 were inhibited by phenylbutazone, estradiol and bilirubin.	Bilirubin	115-124	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	60-66
24359841-13	2014	By multivariate analysis, factors associated with high ALP, total bilirubin and direct bilirubin included CYP2B6 haplotype *6/*6, high serum ALP at Week 0 and positive anti-HCV (all P&lt;0.05).	Bilirubin	87-96	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	106-112
23886114-3	2014	Genome-wide association studies have shown significant association of OATP1B1 and UGT1A1 with elevations of unconjugated bilirubin, and OATP1B1 inhibition data correlated with clinical unconjugated hyperbilirubinemia for several compounds.	Bilirubin	121-130	solute carrier organic anion transporter family member 1B1	Homo sapiens	70-77
23886114-3	2014	Genome-wide association studies have shown significant association of OATP1B1 and UGT1A1 with elevations of unconjugated bilirubin, and OATP1B1 inhibition data correlated with clinical unconjugated hyperbilirubinemia for several compounds.	Bilirubin	121-130	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	82-88
23886114-6	2014	OATP1B1 and OATP1B3-mediated transport of bilirubin was confirmed and inhibition was determined for atazanavir, rifampicin, indinavir, amprenavir, cyclosporine, rifamycin SV and saquinavir.	Bilirubin	42-51	solute carrier organic anion transporter family member 1B1	Homo sapiens	0-7
23886114-6	2014	OATP1B1 and OATP1B3-mediated transport of bilirubin was confirmed and inhibition was determined for atazanavir, rifampicin, indinavir, amprenavir, cyclosporine, rifamycin SV and saquinavir.	Bilirubin	42-51	solute carrier organic anion transporter family member 1B3	Homo sapiens	12-19
24587300-0	2014	Serum bilirubin concentration in healthy adult North-Europeans is strictly controlled by the UGT1A1 TA-repeat variants.	Bilirubin	6-15	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	93-99
24587300-1	2014	The major enzyme responsible for the glucuronidation of bilirubin is the uridine 5"-diphosphoglucose glucuronosyltransferase A1 (UGT1A1) enzyme, and genetic variation in the UGT1A1 gene is reported to influence the bilirubin concentration in the blood.	Bilirubin	56-65	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	129-135
24587300-1	2014	The major enzyme responsible for the glucuronidation of bilirubin is the uridine 5"-diphosphoglucose glucuronosyltransferase A1 (UGT1A1) enzyme, and genetic variation in the UGT1A1 gene is reported to influence the bilirubin concentration in the blood.	Bilirubin	56-65	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	174-180
24587300-1	2014	The major enzyme responsible for the glucuronidation of bilirubin is the uridine 5"-diphosphoglucose glucuronosyltransferase A1 (UGT1A1) enzyme, and genetic variation in the UGT1A1 gene is reported to influence the bilirubin concentration in the blood.	Bilirubin	215-224	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	129-135
24587300-1	2014	The major enzyme responsible for the glucuronidation of bilirubin is the uridine 5"-diphosphoglucose glucuronosyltransferase A1 (UGT1A1) enzyme, and genetic variation in the UGT1A1 gene is reported to influence the bilirubin concentration in the blood.	Bilirubin	215-224	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	174-180
24587300-5	2014	We found significant odds ratios for high bilirubin level for all the selected UGT1A1 variants.	Bilirubin	42-51	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	79-85
24587300-6	2014	However, in stepwise multivariate logistic regression analysis of all genetic variants together with age, sex, country of origin and fasting time, the repeat variants of UGT1A1 TA6&gt;TA7 and SLCO1B3 rs2117032 T&gt;C were the only variants significantly associated with higher bilirubin concentrations.	Bilirubin	277-286	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	170-176
24587300-6	2014	However, in stepwise multivariate logistic regression analysis of all genetic variants together with age, sex, country of origin and fasting time, the repeat variants of UGT1A1 TA6&gt;TA7 and SLCO1B3 rs2117032 T&gt;C were the only variants significantly associated with higher bilirubin concentrations.	Bilirubin	277-286	solute carrier organic anion transporter family member 1B3	Homo sapiens	192-199
24587300-8	2014	Among individuals heterozygous for the TA7-repeat, a low frequent UGT1A1-diplotype harboring the rs7564935 G-variant was associated with higher bilirubin levels.	Bilirubin	144-153	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	66-72
24615116-0	2014	Comparative analysis of bilirubin in correlation to albumin between nephrotic syndrome patients and postoperative gastroparesis syndrome patients.	Bilirubin	24-33	albumin	Homo sapiens	52-59
24615116-2	2014	Correlation analysis was carried out on total bilirubin (TBIL) to serum albumin (ALB), urine protein (Upr), and urinary microalbumin/creatinine (Umalb/cr) for three groups in a case-control study.	Bilirubin	57-61	albumin	Homo sapiens	72-79
23763371-9	2014	Comparison of AFP levels in terms of bilirubin percentile values appropriate for postnatal age also showed a significant weak positive correlation (r = 0.113, p &lt; 0.001).	Bilirubin	37-46	alpha fetoprotein	Homo sapiens	14-17
23982745-0	2014	Rat cerebellar slice cultures exposed to bilirubin evidence reactive gliosis, excitotoxicity and impaired myelinogenesis that is prevented by AMPA and TNF-alpha inhibitors.	Bilirubin	41-50	tumor necrosis factor	Rattus norvegicus	151-160
24331419-9	2014	By contrast, the above inhibitory effects were reversed partially when carbon monoxide (CO) aqueous solution or bilirubin (BR), two of the by-products of HO-1, was added, respectively.	Bilirubin	112-121	heme oxygenase 1, chloroplastic	Triticum aestivum	154-158
24331419-9	2014	By contrast, the above inhibitory effects were reversed partially when carbon monoxide (CO) aqueous solution or bilirubin (BR), two of the by-products of HO-1, was added, respectively.	Bilirubin	123-125	heme oxygenase 1, chloroplastic	Triticum aestivum	154-158
25344086-4	2014	HO-1 along with its reaction products bilirubin and CO are protective against ischemia-induced injury (myocardial infarction, ischemia-reperfusion (IR)-injury and post-infarct structural remodelling).	Bilirubin	38-47	heme oxygenase 1	Homo sapiens	0-4
24818258-5	2014	In addition, LPS/D-GalN induced significant increase of heme oxygenase (HO), carbon monoxide and bilirubin levels and these alterations were augmented by genistein treatment.	Bilirubin	97-106	toll-like receptor 4	Mus musculus	13-16
24818258-5	2014	In addition, LPS/D-GalN induced significant increase of heme oxygenase (HO), carbon monoxide and bilirubin levels and these alterations were augmented by genistein treatment.	Bilirubin	97-106	galanin and GMAP prepropeptide	Mus musculus	19-23
24697119-9	2014	The expression of serum miR-16 is down-regulated in the patients with a tumor more than 5 cm in diameter (p = 0.0013) and is correlated with some quantitative clinical features such as platelets (p = 0.0255), PT (p = 0.0007) and bilirubin (p = 0.0025).	Bilirubin	229-238	glycerophosphodiester phosphodiesterase 1	Homo sapiens	24-30
24416783-8	2014	TNF-alpha, IL-6 and IFN-gamma had significant positive correlation with viral load, serum bilirubin and prothrombin time in pregnant women.	Bilirubin	90-99	tumor necrosis factor	Homo sapiens	0-9
24416783-8	2014	TNF-alpha, IL-6 and IFN-gamma had significant positive correlation with viral load, serum bilirubin and prothrombin time in pregnant women.	Bilirubin	90-99	interleukin 6	Homo sapiens	11-15
24416783-8	2014	TNF-alpha, IL-6 and IFN-gamma had significant positive correlation with viral load, serum bilirubin and prothrombin time in pregnant women.	Bilirubin	90-99	interferon gamma	Homo sapiens	20-29
24256624-7	2014	Propofol (UGT1A9 inhibitor) effectively blocked G4 generation in HLMs (IC50 63.7 +- 11.6 microM), whereas the UGT1A1 inhibitor bilirubin only produced partial inhibition in HLMs and HIMs.	Bilirubin	127-136	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	110-116
24898899-4	2014	The median time to elevation of bilirubin levels in UGT1A1 poor metabolizers was 2.0 weeks (hazard ratio, 6.11).	Bilirubin	32-41	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	52-58
24056816-6	2014	At the same time, the drug down-regulates a variety of genes involved in bilirubin liver clearance: constitutive androstane receptor, multidrug resistance-associated protein, solute carrier organic anion transporters, and even GSTA2.	Bilirubin	73-82	glutathione S-transferase alpha 2	Homo sapiens	227-232
24056816-7	2014	It is worthy of note that GSTA2 also acts as an intra-hepatic bilirubin binding protein.	Bilirubin	62-71	glutathione S-transferase alpha 2	Homo sapiens	26-31
26375741-5	2015	The relationship between A(TA)nTAA variation of UGT1A1 gene, the serum bilirubin level and the occurrence of cholilithiasis was investigated.	Bilirubin	71-80	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	48-54
25411909-7	2015	Diagnoses of hemolytic anemia, decreased red cell count, reduced hemoglobin concentration, and elevated bilirubin level were observed in Hri knockout (Ko) mice only, upon low-dose Pb administration.	Bilirubin	104-113	eukaryotic translation initiation factor 2 alpha kinase 1	Mus musculus	137-140
25632835-1	2015	BACKGROUND: Misdiagnosis of G-6-PD deficiency in neonates, at risk of severe hemolytic episodes, extreme hyperbilirubinemia, and bilirubin encephalopathy, could possibly occur due to presence of reticulocytes, which contain higher amounts of G-6-PD than mature erythrocytes.	Bilirubin	110-119	glucose-6-phosphate dehydrogenase	Homo sapiens	28-34
25636579-11	2015	KIR2DS3-positive patients also had lower mean levels of bilirubin than KIR2DS3-negative ones (p=0.02862).	Bilirubin	56-65	killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3	Homo sapiens	0-7
25045829-6	2015	Increased serum level of IL-6, IFN-gamma and TNF-alpha was correlated with total bilirubin, ALT, PTA and MELD scores in ACHBLF.	Bilirubin	81-90	interleukin 6	Homo sapiens	25-29
25045829-6	2015	Increased serum level of IL-6, IFN-gamma and TNF-alpha was correlated with total bilirubin, ALT, PTA and MELD scores in ACHBLF.	Bilirubin	81-90	interferon gamma	Homo sapiens	31-40
25045829-6	2015	Increased serum level of IL-6, IFN-gamma and TNF-alpha was correlated with total bilirubin, ALT, PTA and MELD scores in ACHBLF.	Bilirubin	81-90	tumor necrosis factor	Homo sapiens	45-54
25648948-0	2015	Serum alanine transaminase total bilirubin concentrations predict CYP3A activity as measured by midazolam and 1"-hydroxylation.	Bilirubin	33-42	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	66-71
25648948-10	2015	Multiple linear regression analysis showed a statistically significant linear relationship between the activity of CYP3A and alanine transaminase (ALT, R2=0.682, P=0.000), and total bilirubin (TB, R2=0.519, P=0.002).	Bilirubin	193-195	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	115-120
25648948-13	2015	The decrease in the activity of CYP3A was determined by the increase in the serum concentration of ALT and TB and not by patient"s age or body weight.	Bilirubin	107-109	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	32-37
25648948-14	2015	ALT and TB therefore might have predictive value for the activity of CYP3A.	Bilirubin	8-10	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	69-74
25593463-8	2015	With time, the levels of ALT, endotoxin and bilirubin in the GLP-2 group were significantly increased compared with the sham group (P &lt; 0.01).	Bilirubin	44-53	mast cell protease 10	Rattus norvegicus	61-66
25593463-10	2015	CONCLUSION: GLP-2 reduces intestinal mucosal injuries in obstructive jaundice rats, which might be attributed to increased intestinal IgA and reduced bilirubin and endotoxin.	Bilirubin	150-159	mast cell protease 10	Rattus norvegicus	12-17
26101189-5	2015	The grades of K-7 expression were significantly associated with the levels of alanine aminotransferase, alkaline phosphatase, and total bilirubin at the time of diagnosis, but not with bile duct loss or cholestasis.	Bilirubin	136-145	keratin 7	Homo sapiens	14-17
26101189-6	2015	Stepwise logistic regression analysis revealed that high grades of K-7 expression correlated positively with high levels of total bilirubin.	Bilirubin	130-139	keratin 7	Homo sapiens	67-70
26632182-2	2015	UGT1A1 enzyme activity is commonly evaluated by detecting the elimination of bilirubin substrate or the generation of bilirubin glucuronides.	Bilirubin	77-86	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
26632182-2	2015	UGT1A1 enzyme activity is commonly evaluated by detecting the elimination of bilirubin substrate or the generation of bilirubin glucuronides.	Bilirubin	118-127	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
26632182-10	2015	rUGT1A1 had the strongest binding affinity for bilirubin, but the lowest metabolism velocity.	Bilirubin	47-56	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-7
26266251-10	2015	The bilirubin level was normalized by Lap-revision in all four patients, and three of them were alive with their native liver.	Bilirubin	4-13	LAP	Homo sapiens	38-41
25732557-1	2015	Human serum albumin (HSA) is the major plasma protein with vital functions acting as depot and career for many endogenous (fatty acids, bilirubin, etc.)	Bilirubin	136-145	albumin	Homo sapiens	6-25
27214983-4	2015	RESULTS: It was found an inverse relationship between the level of IGF-1, and the level of AST, ALT, AST/ALT, total and conjugated bilirubin, alkaline phosphatase in groups of patients with comorbid disorder and also an inverse relationship between the level of IGF-1 and resistin.	Bilirubin	131-140	insulin like growth factor 1	Homo sapiens	67-72
25323532-11	2015	Serum IL-17 levels were positively correlated with total bilirubin (TBIL), alanine aminotransferase (ALT) and Child-Pugh grade, and were negatively correlated with albumin.	Bilirubin	57-66	interleukin 17A	Homo sapiens	6-11
25709219-12	2015	RESULTS AND DISCUSSION: Hepatotoxicity induced with CCl4 was well manifested by significant increase in serum activities of GOT, GPT, ALP and GGT, and enhancement of total bilirubin and TBARS levels.	Bilirubin	172-181	C-C motif chemokine ligand 4	Rattus norvegicus	52-56
25709219-14	2015	Pretreatment with plant extracts and silymarin prevent the toxic effects of CCl4 by decreasing serum enzyme activities, total bilirubin and TBARS levels and improving serum TAP and DPPH-free radical scavenging potential.	Bilirubin	126-135	C-C motif chemokine ligand 4	Rattus norvegicus	76-80
26068529-2	2015	UDP-glucuronosyltransferase 1A1 (UGT1A1) plays an irreplaceable role in detoxification of bilirubin and many drugs (e.g., SN-38).	Bilirubin	90-99	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-31
26068529-2	2015	UDP-glucuronosyltransferase 1A1 (UGT1A1) plays an irreplaceable role in detoxification of bilirubin and many drugs (e.g., SN-38).	Bilirubin	90-99	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	33-39
25561817-13	2014	Patients in the "TTK" group had significantly higher levels of serum total bilirubin compared to MMC subjects (339.40 mumol/L +- 270.09 mumol/L vs 176.13 mumol/L +- 185.70 mumol/L, P = 0.014).	Bilirubin	75-84	TTK protein kinase	Homo sapiens	17-20
25503810-8	2014	These data suggest that the dual effects of enhancement and suppression of bilirubin on nAChR function may be ascribed to the action mechanism of positive allosteric modulation and direct blockade.	Bilirubin	75-84	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	88-93
25331234-7	2014	RESULTS: Both LCA (10 muM) and bilirubin (50 muM) induced apoptosis as indicated by DNA fragmentation (4 7- and 3 7-fold, respectively, P &lt; 0 001), caspase-3 activity and flow cytometry in Saos-2 and hOB.	Bilirubin	31-40	latexin	Homo sapiens	45-48
25331234-7	2014	RESULTS: Both LCA (10 muM) and bilirubin (50 muM) induced apoptosis as indicated by DNA fragmentation (4 7- and 3 7-fold, respectively, P &lt; 0 001), caspase-3 activity and flow cytometry in Saos-2 and hOB.	Bilirubin	31-40	caspase 3	Homo sapiens	151-160
25280089-4	2014	The levels of heme oxygenase-1 (HO-1), oxyhemoglobin, ferritin, and bilirubin in intrathecal CSF were measured on the 7th day posthemorrhage.	Bilirubin	68-77	colony stimulating factor 2	Homo sapiens	93-96
25262300-1	2014	OBJECTIVE: To explore the effects of variants in Uridine Diphosphate Glucuronosyl Transferase 1A1 (UGT1A1) and Heme Oxygenase-1 (HMOX1) on daily physiological bilirubin levels and bilirubin changes during the first week after birth in Chinese newborns.	Bilirubin	159-168	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	49-97
25262300-1	2014	OBJECTIVE: To explore the effects of variants in Uridine Diphosphate Glucuronosyl Transferase 1A1 (UGT1A1) and Heme Oxygenase-1 (HMOX1) on daily physiological bilirubin levels and bilirubin changes during the first week after birth in Chinese newborns.	Bilirubin	159-168	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	99-105
25262300-1	2014	OBJECTIVE: To explore the effects of variants in Uridine Diphosphate Glucuronosyl Transferase 1A1 (UGT1A1) and Heme Oxygenase-1 (HMOX1) on daily physiological bilirubin levels and bilirubin changes during the first week after birth in Chinese newborns.	Bilirubin	159-168	heme oxygenase 1	Homo sapiens	111-127
25262300-1	2014	OBJECTIVE: To explore the effects of variants in Uridine Diphosphate Glucuronosyl Transferase 1A1 (UGT1A1) and Heme Oxygenase-1 (HMOX1) on daily physiological bilirubin levels and bilirubin changes during the first week after birth in Chinese newborns.	Bilirubin	159-168	heme oxygenase 1	Homo sapiens	129-134
25262300-2	2014	Both UGT1A1 and HMOX1 code rate-limiting enzymes in the bilirubin metabolism pathway.	Bilirubin	56-65	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	5-11
25262300-2	2014	Both UGT1A1 and HMOX1 code rate-limiting enzymes in the bilirubin metabolism pathway.	Bilirubin	56-65	heme oxygenase 1	Homo sapiens	16-21
25262300-4	2014	RESULTS: For UGT1A1, we found minor allele A of rs4148323 (G211A, UGT1A1*6) contributed to higher daily bilirubin levels on days 4-6 (with contributions to variations increasing from 4.8% to 12.3%), minor allele T of rs887829 (c-364t) contributed to lower daily bilirubin levels for days 6 and 7 (with contributions to variations increasing from 7.0% to 10.2%) (P &lt; .03 for all).	Bilirubin	104-113	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	13-19
25262300-4	2014	RESULTS: For UGT1A1, we found minor allele A of rs4148323 (G211A, UGT1A1*6) contributed to higher daily bilirubin levels on days 4-6 (with contributions to variations increasing from 4.8% to 12.3%), minor allele T of rs887829 (c-364t) contributed to lower daily bilirubin levels for days 6 and 7 (with contributions to variations increasing from 7.0% to 10.2%) (P &lt; .03 for all).	Bilirubin	104-113	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	66-72
25262300-4	2014	RESULTS: For UGT1A1, we found minor allele A of rs4148323 (G211A, UGT1A1*6) contributed to higher daily bilirubin levels on days 4-6 (with contributions to variations increasing from 4.8% to 12.3%), minor allele T of rs887829 (c-364t) contributed to lower daily bilirubin levels for days 6 and 7 (with contributions to variations increasing from 7.0% to 10.2%) (P &lt; .03 for all).	Bilirubin	262-271	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	13-19
25262300-4	2014	RESULTS: For UGT1A1, we found minor allele A of rs4148323 (G211A, UGT1A1*6) contributed to higher daily bilirubin levels on days 4-6 (with contributions to variations increasing from 4.8% to 12.3%), minor allele T of rs887829 (c-364t) contributed to lower daily bilirubin levels for days 6 and 7 (with contributions to variations increasing from 7.0% to 10.2%) (P &lt; .03 for all).	Bilirubin	262-271	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	66-72
25262300-7	2014	CONCLUSION: Bilirubin levels and changes during the middle and late parts of the first week were attributed to variants and haplotypes in UGT1A1.	Bilirubin	12-21	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	138-144
25550938-0	2014	Interfering effect of bilirubin on the determination of alkaline phosphatase.	Bilirubin	22-31	alkaline phosphatase, placental	Homo sapiens	56-76
25550938-1	2014	OBJECTIVE: This study was designed to evaluate whether the high concentration of bilirubin is able to interfere the determination of alkaline phosphatase (ALP).	Bilirubin	81-90	alkaline phosphatase, placental	Homo sapiens	133-153
25550938-1	2014	OBJECTIVE: This study was designed to evaluate whether the high concentration of bilirubin is able to interfere the determination of alkaline phosphatase (ALP).	Bilirubin	81-90	alkaline phosphatase, placental	Homo sapiens	155-158
25550938-2	2014	METHODS: Clinical tests evaluating the interfering substance of bilirubin of various concentrations on the determination of ALP were conducted based upon the Clinical and Laboratory Standards Institute (CLSI) document EP7-A2, the most recent guideline on interference testing approved in 2005.	Bilirubin	64-73	alkaline phosphatase, placental	Homo sapiens	124-127
25550938-3	2014	RESULTS: Paired t-test comparing different doses of bilirubin revealed that the concentration of 1 000 mummol/L bilirubin negatively interfered the determination of ALP levels.	Bilirubin	52-61	alkaline phosphatase, placental	Homo sapiens	165-168
25550938-3	2014	RESULTS: Paired t-test comparing different doses of bilirubin revealed that the concentration of 1 000 mummol/L bilirubin negatively interfered the determination of ALP levels.	Bilirubin	112-121	alkaline phosphatase, placental	Homo sapiens	165-168
25550938-4	2014	The experiment designed with five different concentrations of bilirubin showed that bilirubin can exert negative interference on the measurement of ALP in a linear pattern.	Bilirubin	62-71	alkaline phosphatase, placental	Homo sapiens	148-151
25550938-4	2014	The experiment designed with five different concentrations of bilirubin showed that bilirubin can exert negative interference on the measurement of ALP in a linear pattern.	Bilirubin	84-93	alkaline phosphatase, placental	Homo sapiens	148-151
25550938-5	2014	CONCLUSION: High concentration of bilirubin can cause false measurement of ALP levels, probably interfering with the clinical prognosis of liver diseases.	Bilirubin	34-43	alkaline phosphatase, placental	Homo sapiens	75-78
25394009-11	2014	Indirect hyperbilirubinemia was consistent with the known ABT-450 inhibition of the OATP1B1 bilirubin transporter, RBV-related haemolytic anaemia and inhibitory effect of ATV on bilirubin conjugation.	Bilirubin	14-23	solute carrier organic anion transporter family member 1B1	Homo sapiens	84-91
25149194-5	2014	In age- and sex-adjusted analysis, total cholesterol, non-HDL cholesterol, triglycerides, apoB, apoE, large VLDL and small LDL were negatively correlated with bilirubin, but HDL cholesterol was positively correlated with bilirubin in T2DM (p&lt;0.05 to p&lt;0.001).	Bilirubin	159-168	apolipoprotein B	Homo sapiens	90-94
25149194-5	2014	In age- and sex-adjusted analysis, total cholesterol, non-HDL cholesterol, triglycerides, apoB, apoE, large VLDL and small LDL were negatively correlated with bilirubin, but HDL cholesterol was positively correlated with bilirubin in T2DM (p&lt;0.05 to p&lt;0.001).	Bilirubin	159-168	apolipoprotein E	Homo sapiens	96-100
24910105-0	2014	Serum bilirubin concentrations are positively associated with serum C-peptide levels in patients with Type 2 diabetes.	Bilirubin	6-15	insulin	Homo sapiens	68-77
24910105-1	2014	AIMS: To investigate the relationship between physiological serum total bilirubin concentrations and serum C-peptide levels in Korean patients with Type 2 diabetes.	Bilirubin	72-81	insulin	Homo sapiens	107-116
24910105-5	2014	Partial correlation analysis showed that serum bilirubin levels were significantly correlated with fasting C-peptide level (r = 0.159, P &lt; 0.001), postprandial C-peptide level (r = 0.209, P &lt; 0.001) and DeltaC-peptide level (r = 0.186, P &lt; 0.001) after adjustment for other covariates.	Bilirubin	47-56	insulin	Homo sapiens	107-116
24910105-5	2014	Partial correlation analysis showed that serum bilirubin levels were significantly correlated with fasting C-peptide level (r = 0.159, P &lt; 0.001), postprandial C-peptide level (r = 0.209, P &lt; 0.001) and DeltaC-peptide level (r = 0.186, P &lt; 0.001) after adjustment for other covariates.	Bilirubin	47-56	insulin	Homo sapiens	163-172
24910105-7	2014	CONCLUSIONS: Serum bilirubin concentrations within the physiological range were positively associated with serum C-peptide levels in patients with Type 2 diabetes.	Bilirubin	19-28	insulin	Homo sapiens	113-122
25147274-7	2014	In addition, glucuronide-conjugated bilirubin concentrations are doubled in serum of H-Cpr-null mice.	Bilirubin	36-45	cytochrome p450 oxidoreductase	Mus musculus	87-90
25196843-2	2014	Biliverdin reductase (BVR) then catalyzes conversion of biliverdin to bilirubin.	Bilirubin	70-79	biliverdin reductase A	Homo sapiens	0-20
25196843-2	2014	Biliverdin reductase (BVR) then catalyzes conversion of biliverdin to bilirubin.	Bilirubin	70-79	biliverdin reductase A	Homo sapiens	22-25
24620945-2	2014	The high levels of bilirubin could be related to the co-inheritance of Gilbert syndrome determined either by mutations of the coding region or by variation in the (TA)n motifs of the promoter region of the bilirubin UGT1A1 gene.	Bilirubin	19-28	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	216-222
24620945-2	2014	The high levels of bilirubin could be related to the co-inheritance of Gilbert syndrome determined either by mutations of the coding region or by variation in the (TA)n motifs of the promoter region of the bilirubin UGT1A1 gene.	Bilirubin	206-215	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	216-222
24620945-5	2014	METHODS: The promoter region (TA)n motifs of the bilirubin UGT1A1 gene were analyzed in 104 beta thalassemia individuals.	Bilirubin	49-58	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	59-65
25091622-5	2014	As a critical mechanism, we showed that TUS activated heme oxygenase-1 (HO-1), which degrades heme to immunosuppressive products, such as carbon monoxide and bilirubin.	Bilirubin	158-167	heme oxygenase 1	Homo sapiens	54-70
25091622-5	2014	As a critical mechanism, we showed that TUS activated heme oxygenase-1 (HO-1), which degrades heme to immunosuppressive products, such as carbon monoxide and bilirubin.	Bilirubin	158-167	heme oxygenase 1	Homo sapiens	72-76
24516079-8	2014	Of the ATV/rit-treated patients, 14 were found to be carriers of the UGT1A1*28 variant (54%), and maximum serum bilirubin levels were significantly higher in the carrier population (4.71 vs. 2.69 mg/dL, p = 0.026).	Bilirubin	112-121	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	69-75
25068656-7	2014	As opposed to single transgenes, Atp8b1(G308V/G308V)/Hrn and Abcb4(-/-)/Hrn mice rapidly developed strong cholestasis that was evidenced by increased plasma bilirubin and bile salt levels.	Bilirubin	157-166	ATPase, class I, type 8B, member 1	Mus musculus	33-39
25068656-7	2014	As opposed to single transgenes, Atp8b1(G308V/G308V)/Hrn and Abcb4(-/-)/Hrn mice rapidly developed strong cholestasis that was evidenced by increased plasma bilirubin and bile salt levels.	Bilirubin	157-166	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	61-66
24526315-6	2014	However, patients with the highest AFP levels had larger tumors and higher bilirubin levels, reflecting an aggressive biology.	Bilirubin	75-84	alpha fetoprotein	Homo sapiens	35-38
25209391-2	2014	This study experimentally investigated whether additional glucose treatments induce the bilirubin-metabolizing enzyme--UDP-glucuronosyltransferase (UGT) 1A1--to prevent the onset of neonatal hyperbilirubinemia.	Bilirubin	88-97	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	119-156
25209391-8	2014	Adequate calorie intake would lead to the sufficient expression of UGT1A1 in the small intestine to reduce serum bilirubin levels.	Bilirubin	113-122	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	67-73
25044472-10	2014	Propofol (UGT1A9 inhibitor) produced a complete inhibition of 3"-glucuronide formation accompanied by an increase of 7-glucuronide in HLMs, while bilirubin (UGT1A1 inhibitor) only partially (~60%) inhibited the 7-OH glucuronidation.	Bilirubin	146-155	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	157-163
25062689-2	2014	It is usually a temporary condition caused by delayed induction of UGT1A1, which conjugates bilirubin in the liver.	Bilirubin	92-101	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	67-73
25309795-3	2014	As biliverdin and bilirubin produced by heme oxygenase isoform 1 (HO-1) have antioxidant properties, the production of both antioxidants by HO-1 may help increase the resistance of the ischemic brain to oxidative stress.	Bilirubin	18-27	heme oxygenase 1	Rattus norvegicus	40-64
25309795-3	2014	As biliverdin and bilirubin produced by heme oxygenase isoform 1 (HO-1) have antioxidant properties, the production of both antioxidants by HO-1 may help increase the resistance of the ischemic brain to oxidative stress.	Bilirubin	18-27	heme oxygenase 1	Rattus norvegicus	66-70
25309795-8	2014	HO-1 activity was also important in providing bilirubin as an antioxidant.	Bilirubin	46-55	heme oxygenase 1	Rattus norvegicus	0-4
24933018-3	2014	DHP was found to effectively depress the increased ratio of liver weight to body weight, reduce the elevated levels of serum aspartate aminotransferase, total cholesterol, total bilirubin and low density lipoprotein, and alleviate hepatic steatosis in mice with ethanol-induced subacute liver injury.	Bilirubin	178-187	dihydropyrimidinase	Mus musculus	0-3
25072305-9	2014	We propose that this remarkable difference in gene therapy efficacy could be related to the absence of the Mrp2 and Mrp3 transporters of conjugated bilirubin in muscle.	Bilirubin	148-157	prolactin family 2, subfamily c, member 3	Mus musculus	107-111
25072305-9	2014	We propose that this remarkable difference in gene therapy efficacy could be related to the absence of the Mrp2 and Mrp3 transporters of conjugated bilirubin in muscle.	Bilirubin	148-157	prolactin family 2, subfamily c, member 4	Mus musculus	116-120
25317019-0	2014	Bilirubin activates transcription of HIF-1alpha in human proximal tubular cells cultured in the physiologic oxygen content.	Bilirubin	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-47
25317019-2	2014	Effect of bilirubin on HIF-1 expression in proximal tubular cells was investigated under physiological oxygen concentration, which is relative hypoxic condition mimicking oxygen content in the medulla of renal tissue.	Bilirubin	10-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-28
25317019-4	2014	HIF-1alpha protein expression was increased by bilirubin treatment at 0.01-0.2 mg/dL concentration.	Bilirubin	47-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
25317019-5	2014	The messenger RNA expression of HIF-1alpha was increased by 1.69+-0.05 folds in the cells cultured with 0.1 mg/dL bilirubin, compared to the control cells.	Bilirubin	114-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-42
25317019-7	2014	HIF-1alpha expression decreased by 10 microM exogenous hydrogen peroxide (H2O2); scavenger of ROS with or without bilirubin in the HK2 cells increased HIF-1alpha concentration more than that in the cells without bilirubin.	Bilirubin	114-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	151-161
25317019-7	2014	HIF-1alpha expression decreased by 10 microM exogenous hydrogen peroxide (H2O2); scavenger of ROS with or without bilirubin in the HK2 cells increased HIF-1alpha concentration more than that in the cells without bilirubin.	Bilirubin	212-221	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
25317019-10	2014	In coonclusion, bilirubin enhances HIF-1alpha transcription as well as the up-regulation of HIF-1alpha protein translation through the attenuation of ROS and subunits of NADPH oxidase.	Bilirubin	16-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-45
25317020-8	2014	Bilirubin suppressed protein expression of LXRalpha, SREBP-1, SCD-1, and FAS, factors involved in TG synthesis that were elevated in the livers of DM rats and hepatoma cells under high-glucose conditions.	Bilirubin	0-9	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	43-51
25317020-8	2014	Bilirubin suppressed protein expression of LXRalpha, SREBP-1, SCD-1, and FAS, factors involved in TG synthesis that were elevated in the livers of DM rats and hepatoma cells under high-glucose conditions.	Bilirubin	0-9	sterol regulatory element binding transcription factor 1	Rattus norvegicus	53-60
25317020-8	2014	Bilirubin suppressed protein expression of LXRalpha, SREBP-1, SCD-1, and FAS, factors involved in TG synthesis that were elevated in the livers of DM rats and hepatoma cells under high-glucose conditions.	Bilirubin	0-9	stearoyl-CoA desaturase	Rattus norvegicus	62-67
24909372-1	2014	Several studies have reported that statins occasionally cause impairment of liver functions characterized by elevated serum bilirubin levels, which might be due to altered function of the multidrug resistance-associated proteins (Mrp2/3).	Bilirubin	124-133	ATP binding cassette subfamily C member 2	Rattus norvegicus	230-234
24909372-5	2014	Rosuvastatin stimulated not only the Mrp2 mediated biliary, but the Mrp3 mediated sinusoidal elimination, resulting in decreased intracellular bilirubin accumulation.	Bilirubin	143-152	ATP binding cassette subfamily C member 3	Rattus norvegicus	68-72
25571633-11	2014	CONCLUSION: Upregulated HO-1 level can improve the endothelial function, inhibite of the inflammatory response and enhance the antioxidant substances in serum bilirubin via peNOS-pAMPK pathway, which effectively inhibit ventricular remodeling and improve the long-term cardiac function after infarction in diabetic rats.	Bilirubin	159-168	heme oxygenase 1	Rattus norvegicus	24-28
24865931-7	2014	This study demonstrates that UGT1A1 and OATP2 polymorphisms were associated with altered bilirubin metabolism and could be genetic risk factors for neonatal hyperbilirubinemia.	Bilirubin	89-98	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	29-35
24865931-7	2014	This study demonstrates that UGT1A1 and OATP2 polymorphisms were associated with altered bilirubin metabolism and could be genetic risk factors for neonatal hyperbilirubinemia.	Bilirubin	89-98	solute carrier organic anion transporter family member 1B1	Homo sapiens	40-45
25100243-14	2014	Bilirubin correlated inversely to NPP7 and was higher in the tumour than in the gallstone group.	Bilirubin	0-9	ectonucleotide pyrophosphatase/phosphodiesterase 7	Homo sapiens	34-38
24785582-1	2014	BACKGROUND: Gilbert"s syndrome is one of the most common metabolic syndromes in the human population characterised by mild unconjugated hyperbilirubinemia resulting from reduced activity of the bilirubin conjugating enzyme UDP-glucuronosyltransferase (UGT1A1).	Bilirubin	141-150	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	252-258
24633678-9	2014	Bilirubin was inversely correlated with CAC in men [estimated % change in (CAC + 1) per each gender-specific standard deviation of bilirubin [95 % confidence interval (CI): -6.1 (-11.6; -1.7) %, p = 0.032] but less so in women [-3.6 (-7.7; 0.2) %, p = 0.065], when adjusting for age only.	Bilirubin	0-9	transmembrane protein 54	Homo sapiens	75-82
24633678-9	2014	Bilirubin was inversely correlated with CAC in men [estimated % change in (CAC + 1) per each gender-specific standard deviation of bilirubin [95 % confidence interval (CI): -6.1 (-11.6; -1.7) %, p = 0.032] but less so in women [-3.6 (-7.7; 0.2) %, p = 0.065], when adjusting for age only.	Bilirubin	131-140	transmembrane protein 54	Homo sapiens	75-82
24912992-2	2014	Pretreatment with GCA and GCR, containing sweroside, swertiamarin and gentiopicrin in high concentrations, dose-dependently and significantly decreased the levels of serum transaminases, alkaline phosphatase and total bilirubin, whereas an increase in the level of total protein was found compared with the CCl4-treated group.	Bilirubin	218-227	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	26-29
24650397-10	2014	CONCLUSION: One-half of the infants with BMJ were homozygous UGT1A1*6 and exhibited a serum bilirubin concentration significantly greater than other genotypes.	Bilirubin	92-101	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	61-67
24650397-12	2014	Previous finding have demonstrated that 5beta-pregnane-3alpha,20beta-diol present in breast milk inhibits p.G71R-UGT1A1 bilirubin glucuronidation activity.	Bilirubin	120-129	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	113-119
24909480-0	2014	The relationship between serum bilirubin level with interleukin-6, interleukin-10 and mortality scores in patients with sepsis.	Bilirubin	31-40	interleukin 6	Homo sapiens	52-65
24909480-0	2014	The relationship between serum bilirubin level with interleukin-6, interleukin-10 and mortality scores in patients with sepsis.	Bilirubin	31-40	interleukin 10	Homo sapiens	67-81
24909480-10	2014	Both SOFA scores and serum IL-10 levels were positively correlated with bilirubin levels 24 h after diagnosis (P &lt; 0.05, r = -0.76).	Bilirubin	72-81	interleukin 10	Homo sapiens	27-32
24973921-6	2014	In patients with hepatitis B, PAF-AH activity correlated with total bilirubin (r=0.633), total bile acid (r=0.559), aspartate aminotransferase (r=0.332), apolipoprotein B (r=0.348), high-density lipoprotein cholesterol (r=-0.493), and apolipoprotein AI (r=-0.530).	Bilirubin	68-77	phospholipase A2 group VII	Homo sapiens	30-36
24968270-7	2014	Among these variables, a multiple comparison test identified that platelet counts and total bilirubin levels were associated with serum chemerin levels (p &lt; 0.0083).	Bilirubin	92-101	retinoic acid receptor responder 2	Homo sapiens	136-144
30805380-9	2014	In the G-CSF+SCF and TAA group the total bilirubin content mean (0.15 versus 0.14 mg/dl, respectively) this difference was not statistically significant (P&gt;0.05).	Bilirubin	41-50	colony stimulating factor 3	Rattus norvegicus	7-16
24326153-4	2014	A partial correlation analysis was carried out to assess the relationship between G6PD activity and total bilirubin levels.	Bilirubin	106-115	glucose-6-phosphate dehydrogenase	Homo sapiens	82-86
24326153-9	2014	CONCLUSION: Routine checks of G6PD level in hyperbilirubinemic neonates are very important in providing proper medical management to prevent bilirubin-induced neurological dysfunction.	Bilirubin	49-58	glucose-6-phosphate dehydrogenase	Homo sapiens	30-34
25190163-11	2014	The inconsistency between serum bilirubin and ALT levels was an important factor that suggested poor prognosis of ALF, and it might increase survival rate to use BP therapy before that inconsistency emerged.	Bilirubin	32-41	afamin	Homo sapiens	114-117
24589992-9	2014	The spatial arrangement of the bilirubin bound to serum albumin along with the studied mutagens was modelled using ligand docking, which revealed a possibility of an arrangement of the both bilirubin and 2-aminofluorene and 2,4,7-trinitrofluorenone in the primary binding site of human serum albumin.	Bilirubin	31-40	albumin	Homo sapiens	50-63
24589992-9	2014	The spatial arrangement of the bilirubin bound to serum albumin along with the studied mutagens was modelled using ligand docking, which revealed a possibility of an arrangement of the both bilirubin and 2-aminofluorene and 2,4,7-trinitrofluorenone in the primary binding site of human serum albumin.	Bilirubin	31-40	albumin	Homo sapiens	286-299
24589992-9	2014	The spatial arrangement of the bilirubin bound to serum albumin along with the studied mutagens was modelled using ligand docking, which revealed a possibility of an arrangement of the both bilirubin and 2-aminofluorene and 2,4,7-trinitrofluorenone in the primary binding site of human serum albumin.	Bilirubin	190-199	albumin	Homo sapiens	50-63
24589992-9	2014	The spatial arrangement of the bilirubin bound to serum albumin along with the studied mutagens was modelled using ligand docking, which revealed a possibility of an arrangement of the both bilirubin and 2-aminofluorene and 2,4,7-trinitrofluorenone in the primary binding site of human serum albumin.	Bilirubin	190-199	albumin	Homo sapiens	286-299
23775679-0	2014	Sixth hour transcutaneous bilirubin predicting significant hyperbilirubinemia in ABO incompatible neonates.	Bilirubin	26-35	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	81-84
24732756-8	2014	Furthermore, carriers homozygous for the ABCC2 -1774G/-1549A/-24T/1249G/3972T/4544G haplotype were found to have a higher propensity for total bilirubin elevations when developing DILI.	Bilirubin	143-152	ATP binding cassette subfamily C member 2	Homo sapiens	41-46
24708607-0	2014	Physical activity and total serum bilirubin levels among insulin sensitive and insulin resistant U.S. adults.	Bilirubin	34-43	insulin	Homo sapiens	57-64
24708607-4	2014	The purpose of this study was to examine the association between accelerometer-assessed physical activity and total serum bilirubin among a national sample of U.S. insulin sensitive and insulin resistant adults.	Bilirubin	122-131	insulin	Homo sapiens	164-171
24708607-9	2014	RESULTS: After adjusting for age, gender, race-ethnicity, BMI, comorbid illness, cotinine, and poverty level, moderate-to-vigorous physical activity (MVPA) was associated with bilirubin for insulin resistant individuals (beta = 0.08; p = 0.04), but not insulin sensitive individuals (beta = 0.02; p = 0.38).	Bilirubin	176-185	insulin	Homo sapiens	190-197
24708607-10	2014	CONCLUSIONS: MVPA is associated with total serum bilirubin levels among U.S. adults with insulin resistance.	Bilirubin	49-58	insulin	Homo sapiens	89-96
24696418-0	2014	Bilirubin levels and their association with carotid intima media thickness and high-sensitivity C-reactive protein in patients with psoriasis vulgaris.	Bilirubin	0-9	C-reactive protein	Homo sapiens	96-114
24333075-9	2014	Multiple regression analysis revealed that the concentrations of haemoglobin, lactate dehydrogenase and indirect bilirubin were independently correlated with pre-therapy EMP levels in ABO HDN.	Bilirubin	113-122	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	184-187
24459177-3	2014	Under normal conditions, unconjugated bilirubin is taken up into hepatocytes by transporters of the organic anion-transporting polypeptide (OATP) family, followed by conjugation with glucuronic acid, and ATP-dependent transport into bile.	Bilirubin	38-47	solute carrier organic anion transporter family member 1A2	Homo sapiens	100-138
24459177-3	2014	Under normal conditions, unconjugated bilirubin is taken up into hepatocytes by transporters of the organic anion-transporting polypeptide (OATP) family, followed by conjugation with glucuronic acid, and ATP-dependent transport into bile.	Bilirubin	38-47	solute carrier organic anion transporter family member 1A2	Homo sapiens	140-144
24459177-4	2014	This efflux across the canalicular membrane is mediated by multidrug resistance protein 2 (MRP2 or ABCC2), which is a 190-kDa glycoprotein transporting with high affinity and efficiency monoglucuronosyl bilirubin and bisglucuronosyl bilirubin into bile.	Bilirubin	203-212	ATP binding cassette subfamily C member 2	Homo sapiens	91-95
24459177-4	2014	This efflux across the canalicular membrane is mediated by multidrug resistance protein 2 (MRP2 or ABCC2), which is a 190-kDa glycoprotein transporting with high affinity and efficiency monoglucuronosyl bilirubin and bisglucuronosyl bilirubin into bile.	Bilirubin	203-212	ATP binding cassette subfamily C member 2	Homo sapiens	99-104
24459177-4	2014	This efflux across the canalicular membrane is mediated by multidrug resistance protein 2 (MRP2 or ABCC2), which is a 190-kDa glycoprotein transporting with high affinity and efficiency monoglucuronosyl bilirubin and bisglucuronosyl bilirubin into bile.	Bilirubin	233-242	ATP binding cassette subfamily C member 2	Homo sapiens	91-95
24459177-4	2014	This efflux across the canalicular membrane is mediated by multidrug resistance protein 2 (MRP2 or ABCC2), which is a 190-kDa glycoprotein transporting with high affinity and efficiency monoglucuronosyl bilirubin and bisglucuronosyl bilirubin into bile.	Bilirubin	233-242	ATP binding cassette subfamily C member 2	Homo sapiens	99-104
24459177-8	2014	Human MRP3 is the only basolateral efflux pump shown to transport bilirubin glucuronides.	Bilirubin	66-75	ATP binding cassette subfamily C member 3	Homo sapiens	6-10
24525562-0	2014	Simultaneous determination of bilirubin and its glucuronides in liver microsomes and recombinant UGT1A1 enzyme incubation systems by HPLC method and its application to bilirubin glucuronidation studies.	Bilirubin	30-39	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	97-103
24525562-1	2014	Bilirubin, an important endogenous substances and liver function index in humans, is primarily eliminated via UGT1A1-catalyzed glucuronidation.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	110-116
24525562-8	2014	Furthermore, we established stable, reliable in vitro incubation systems and optimized the incubation conditions to characterize the kinetics of bilirubin glucuronidation by RLM, HLM and UGT1A1, respectively.	Bilirubin	145-154	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	187-193
24525562-10	2014	Bilirubin glucuronidation obeyed the Hill equation by RLM and the Michaelis-Menten equation by HLM and UGT1A1 in the range of substrate concentration selected, respectively.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	103-109
24597695-6	2014	In humans, serum miR-210 levels enhanced with hepatitis severity and were related to serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TB) and prothrombin activity (PTA) levels.	Bilirubin	163-172	microRNA 210	Homo sapiens	17-24
24557078-7	2014	By multivariate analysis, higher peak on-treatment bilirubin levels were found to be associated with the UGT1A1 rs887829 T allele (P=6.4x10(-12)), higher baseline hemoglobin levels (P=4.9x10(-13)), higher baseline bilirubin levels (P=6.7x10(-12)), and slower plasma atazanavir clearance (P=8.6x10(-11)).	Bilirubin	51-60	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	105-111
24557078-11	2014	CONCLUSION: Atazanavir-associated hyperbilirubinemia is best predicted by considering UGT1A1 genotype, baseline bilirubin level, and baseline hemoglobin level in combination.	Bilirubin	39-48	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	86-92
24690955-2	2014	Bilirubin is produced by heme oxygenase-1 (HO-1), catalyzed by UDP-glucuronosyltransferase (UGT1A1), and has potential as an antioxidant.	Bilirubin	0-9	heme oxygenase 1	Homo sapiens	25-41
24690955-2	2014	Bilirubin is produced by heme oxygenase-1 (HO-1), catalyzed by UDP-glucuronosyltransferase (UGT1A1), and has potential as an antioxidant.	Bilirubin	0-9	heme oxygenase 1	Homo sapiens	43-47
24690955-2	2014	Bilirubin is produced by heme oxygenase-1 (HO-1), catalyzed by UDP-glucuronosyltransferase (UGT1A1), and has potential as an antioxidant.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	92-98
24690955-8	2014	Post-transplant 1-year bilirubin level was higher in 6/7 or 7/7 carriers compared with 6/6 homozygotes in terms of the UGT1A1*28 polymorphism (6/6 vs. 6/7 vs. 7/7: 0.71 +- 0.27 vs. 1.06 +- 0.36 vs. 1.10 +- 0.45 mg/dL, P&lt;0.001).	Bilirubin	23-32	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	119-125
24690955-12	2014	CONCLUSIONS: The UGT1A1*28 polymorphism is associated with changes in serum bilirubin and with graft outcome after kidney transplantation.	Bilirubin	76-85	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	17-23
24787296-6	2014	In the total cohort, elevated bilirubin levels were associated with higher AFP levels, increased PVT and multifocality, and lower survival, despite similar tumor sizes.	Bilirubin	30-39	alpha fetoprotein	Homo sapiens	75-78
24595410-0	2014	The relationship of the anti-oxidant bilirubin with free thyroxine is modified by insulin resistance in euthyroid subjects.	Bilirubin	37-46	insulin	Homo sapiens	82-89
24595410-2	2014	Insulin resistance is featured by low circulating bilirubin.	Bilirubin	50-59	insulin	Homo sapiens	0-7
24595410-8	2014	The relationship of bilirubin with free T4 was modified by insulin resistance with a larger effect in more insulin resistant individuals (adjusted for age and sex: beta = 0.043, P = 0.056 for interaction; additionally adjusted for smoking, alcohol intake, transaminases and total cholesterol (beta = 0.044, P = 0.044 for interaction).	Bilirubin	20-29	insulin	Homo sapiens	59-66
24595410-8	2014	The relationship of bilirubin with free T4 was modified by insulin resistance with a larger effect in more insulin resistant individuals (adjusted for age and sex: beta = 0.043, P = 0.056 for interaction; additionally adjusted for smoking, alcohol intake, transaminases and total cholesterol (beta = 0.044, P = 0.044 for interaction).	Bilirubin	20-29	insulin	Homo sapiens	107-114
24595410-11	2014	Low normal free T4 may particularly confer low bilirubin in more insulin resistant individuals.	Bilirubin	47-56	insulin	Homo sapiens	65-72
24308969-0	2014	Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway.	Bilirubin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	81-85
24308969-5	2014	The aim of the present study was to investigate the role of Nrf2 pathway in cell response to bilirubin mediated oxidative stress in the neuroblastoma SH-SY5Y cell line.	Bilirubin	93-102	NFE2 like bZIP transcription factor 2	Homo sapiens	60-64
24424052-7	2014	Bilirubin treatment increased protein kinase B (PKB/Akt) phosphorylation in skeletal muscle and suppressed expression of ER stress markers, including the 78-kDa glucose-regulated protein (GRP78), CCAAT/enhancer-binding protein (C/EBP) homologous protein, X box binding protein (XBP-1), and activating transcription factor 4 in db/db mice.	Bilirubin	0-9	heat shock protein 5	Mus musculus	154-186
24424052-7	2014	Bilirubin treatment increased protein kinase B (PKB/Akt) phosphorylation in skeletal muscle and suppressed expression of ER stress markers, including the 78-kDa glucose-regulated protein (GRP78), CCAAT/enhancer-binding protein (C/EBP) homologous protein, X box binding protein (XBP-1), and activating transcription factor 4 in db/db mice.	Bilirubin	0-9	heat shock protein 5	Mus musculus	188-193
24424052-7	2014	Bilirubin treatment increased protein kinase B (PKB/Akt) phosphorylation in skeletal muscle and suppressed expression of ER stress markers, including the 78-kDa glucose-regulated protein (GRP78), CCAAT/enhancer-binding protein (C/EBP) homologous protein, X box binding protein (XBP-1), and activating transcription factor 4 in db/db mice.	Bilirubin	0-9	X-box binding protein 1	Mus musculus	278-283
24424052-7	2014	Bilirubin treatment increased protein kinase B (PKB/Akt) phosphorylation in skeletal muscle and suppressed expression of ER stress markers, including the 78-kDa glucose-regulated protein (GRP78), CCAAT/enhancer-binding protein (C/EBP) homologous protein, X box binding protein (XBP-1), and activating transcription factor 4 in db/db mice.	Bilirubin	0-9	activating transcription factor 4	Mus musculus	290-323
24424052-9	2014	Moreover, bilirubin suppressed macrophage infiltration and proinflammatory cytokine expression, including TNF-alpha, IL-1beta, and monocyte chemoattractant protein-1, in adipose tissue.	Bilirubin	10-19	tumor necrosis factor	Mus musculus	106-115
24424052-9	2014	Moreover, bilirubin suppressed macrophage infiltration and proinflammatory cytokine expression, including TNF-alpha, IL-1beta, and monocyte chemoattractant protein-1, in adipose tissue.	Bilirubin	10-19	interleukin 1 beta	Mus musculus	117-125
24424052-9	2014	Moreover, bilirubin suppressed macrophage infiltration and proinflammatory cytokine expression, including TNF-alpha, IL-1beta, and monocyte chemoattractant protein-1, in adipose tissue.	Bilirubin	10-19	chemokine (C-C motif) ligand 2	Mus musculus	131-165
24407487-7	2014	Serum bilirubin levels were significantly lower in patients with CD within all UGT1A1*28 genotypes (P &lt; 0.05).	Bilirubin	6-15	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	79-85
24407487-11	2014	UGT1A1*28 allele homozygosity, responsible for higher bilirubin levels, seems to be an important modifier of CD manifestation.	Bilirubin	54-63	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
25328328-6	2014	RESULTS: In cross-sectional analyses, when the cohort was divided into quartiles of age, higher baseline serum bilirubin levels were associated with older age in analyses adjusted for sex, body mass index (BMI), alanine aminotransferase (ALT), albumin, and metabolic traits (P-value &lt;0.001).	Bilirubin	111-120	glutamic--pyruvic transaminase	Homo sapiens	212-236
24689565-4	2014	Removal of bilirubin in a blood-phantom (hemoglobin and human serum albumin) solution from an enhanced level of 77 muM/l (human jaundice &gt;50 muM/l) to ~30 muM/l (normal level ~25 muM/l in human) using our strategy has been successfully demonstrated.	Bilirubin	11-20	latexin	Homo sapiens	115-118
24689565-4	2014	Removal of bilirubin in a blood-phantom (hemoglobin and human serum albumin) solution from an enhanced level of 77 muM/l (human jaundice &gt;50 muM/l) to ~30 muM/l (normal level ~25 muM/l in human) using our strategy has been successfully demonstrated.	Bilirubin	11-20	latexin	Homo sapiens	144-147
24689565-4	2014	Removal of bilirubin in a blood-phantom (hemoglobin and human serum albumin) solution from an enhanced level of 77 muM/l (human jaundice &gt;50 muM/l) to ~30 muM/l (normal level ~25 muM/l in human) using our strategy has been successfully demonstrated.	Bilirubin	11-20	latexin	Homo sapiens	144-147
24689565-4	2014	Removal of bilirubin in a blood-phantom (hemoglobin and human serum albumin) solution from an enhanced level of 77 muM/l (human jaundice &gt;50 muM/l) to ~30 muM/l (normal level ~25 muM/l in human) using our strategy has been successfully demonstrated.	Bilirubin	11-20	latexin	Homo sapiens	144-147
24748190-8	2014	RESULTS: Compared with the control group, the rats administered BMSCs with over-expressed MMP1 showed a significant improvement in the body weight, liver weight and plasma albumin (ALB) (P&lt;0.05), and a significant reduction in the plasma alanine aminotransferase, total bilirubin, hyaluronic acid, laminin and procollagen III (P&lt;0.05).	Bilirubin	273-282	matrix metallopeptidase 1	Rattus norvegicus	90-94
24403077-0	2014	Developmental onset of bilirubin-induced neurotoxicity involves Toll-like receptor 2-dependent signaling in humanized UDP-glucuronosyltransferase1 mice.	Bilirubin	23-32	toll-like receptor 2	Mus musculus	64-84
24403077-2	2014	In mammals, UDP-glucuronosyltransferase 1A1 (UGT1A1) is the sole enzyme responsible for bilirubin glucuronidation, a rate-limiting step necessary for bilirubin metabolism and clearance.	Bilirubin	88-97	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	12-43
24403077-2	2014	In mammals, UDP-glucuronosyltransferase 1A1 (UGT1A1) is the sole enzyme responsible for bilirubin glucuronidation, a rate-limiting step necessary for bilirubin metabolism and clearance.	Bilirubin	88-97	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	45-51
24403077-2	2014	In mammals, UDP-glucuronosyltransferase 1A1 (UGT1A1) is the sole enzyme responsible for bilirubin glucuronidation, a rate-limiting step necessary for bilirubin metabolism and clearance.	Bilirubin	150-159	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	12-43
24403077-2	2014	In mammals, UDP-glucuronosyltransferase 1A1 (UGT1A1) is the sole enzyme responsible for bilirubin glucuronidation, a rate-limiting step necessary for bilirubin metabolism and clearance.	Bilirubin	150-159	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	45-51
24403077-9	2014	In addition, bilirubin-induced apoptosis was significantly enhanced by blocking TLR2 signaling indicating its anti-apoptotic property.	Bilirubin	13-22	toll-like receptor 2	Mus musculus	80-84
24388834-3	2014	PXR is a master gene orchestrating the expression/activity of genes involved in the metabolism of endobiotics including bilirubin, bile acids, glucose and lipid.	Bilirubin	120-129	nuclear receptor subfamily 1 group I member 2	Homo sapiens	0-3
24243081-5	2014	Application of our model revealed that an absolute value or a steady state increase in bilirubin falling below 3.8Phi micromol/L (where Phi is a correction factor, =1 for UGT1A1 wild type and  1 for UGT1A1 variants) could be used to predict suboptimal atazanavir exposure and treatment failure.	Bilirubin	87-96	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	171-177
24243081-5	2014	Application of our model revealed that an absolute value or a steady state increase in bilirubin falling below 3.8Phi micromol/L (where Phi is a correction factor, =1 for UGT1A1 wild type and  1 for UGT1A1 variants) could be used to predict suboptimal atazanavir exposure and treatment failure.	Bilirubin	87-96	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	199-205
24243081-6	2014	Thus, we have successfully established a new mathematical approach for pharmacodynamic-pharmacokinetic modelling of the interaction between atazanavir and bilirubin, as it relates to genetic variants of UGT1A1.	Bilirubin	155-164	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	203-209
24287929-2	2014	METHODS: Plasma miR-122 expression in patients with HCC and healthy age-matched controls was determined, and correlated with plasma alanine transaminase activity (ALT) and bilirubin levels preoperatively and on days 1 and 7 postoperation.	Bilirubin	172-181	microRNA 122	Homo sapiens	16-23
24287929-6	2014	MiR-122 expression correlated with ALT and bilirubin levels preoperatively and on days 1 and 7 postoperatively.	Bilirubin	43-52	microRNA 122	Homo sapiens	0-7
24815493-12	2014	Higher serum total bilirubin is an indication that patients UGT1A1 genotype is not wild-type, with significance for clinic usage of CPT-11.	Bilirubin	19-28	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	60-66
25016708-1	2014	BACKGROUND: Uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) is a key conjugating enzyme of bilirubin and the anti-tumor medication irinotecan.	Bilirubin	101-110	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	12-60
25016708-1	2014	BACKGROUND: Uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) is a key conjugating enzyme of bilirubin and the anti-tumor medication irinotecan.	Bilirubin	101-110	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	62-68
25185432-0	2014	Evaluation of the in vitro interference of bilirubin and lipids in the measurement of the plasma glutathione reductase activity.	Bilirubin	43-52	glutathione-disulfide reductase	Homo sapiens	97-118
25185432-2	2014	Therefore, the aim of this study was to evaluate the in vitro interference of bilirubin and lipids in the measurement of the activity of glutathione reductase (GR) in plasma samples.	Bilirubin	78-87	glutathione-disulfide reductase	Homo sapiens	137-158
25185432-2	2014	Therefore, the aim of this study was to evaluate the in vitro interference of bilirubin and lipids in the measurement of the activity of glutathione reductase (GR) in plasma samples.	Bilirubin	78-87	glutathione-disulfide reductase	Homo sapiens	160-162
25185432-6	2014	RESULTS: Plasma GR activity was significantly affected by bilirubin and lipids.	Bilirubin	58-67	glutathione-disulfide reductase	Homo sapiens	16-18
25185432-7	2014	At the concentrations of 0.9 to 30 mg/dL of bilirubin added, the decrease of GR activity ranged between 22.9 to 45.4%.	Bilirubin	44-53	glutathione-disulfide reductase	Homo sapiens	77-79
25185432-9	2014	CONCLUSIONS: The addition of bilirubin and lipids in plasma samples interferes negatively in the measurement of GR activity, since GR values are reduced in the presence of these in vitro interferents.	Bilirubin	29-38	glutathione-disulfide reductase	Homo sapiens	112-114
25185432-9	2014	CONCLUSIONS: The addition of bilirubin and lipids in plasma samples interferes negatively in the measurement of GR activity, since GR values are reduced in the presence of these in vitro interferents.	Bilirubin	29-38	glutathione-disulfide reductase	Homo sapiens	131-133
25049438-8	2014	The significant positive correlation between total serum bilirubin and urinary NAG index was found in newborns when total serum bilirubin level was more than 272 mumol/L.	Bilirubin	57-66	O-GlcNAcase	Homo sapiens	79-82
25049438-8	2014	The significant positive correlation between total serum bilirubin and urinary NAG index was found in newborns when total serum bilirubin level was more than 272 mumol/L.	Bilirubin	128-137	O-GlcNAcase	Homo sapiens	79-82
25196354-4	2014	METHODS: Expression of the canalicular bile salt export pump BSEP (ABCC11), phospholipid flippase MDR3 (ABCB4) and bilirubin export pump MRP2 (ABCC2) was assessed immunohistochemically in liver biopsies from 23 patients with DILI.	Bilirubin	115-124	ATP binding cassette subfamily C member 2	Homo sapiens	137-141
25196354-4	2014	METHODS: Expression of the canalicular bile salt export pump BSEP (ABCC11), phospholipid flippase MDR3 (ABCB4) and bilirubin export pump MRP2 (ABCC2) was assessed immunohistochemically in liver biopsies from 23 patients with DILI.	Bilirubin	115-124	ATP binding cassette subfamily C member 2	Homo sapiens	143-148
25147562-0	2014	PPARalpha: A Master Regulator of Bilirubin Homeostasis.	Bilirubin	33-42	peroxisome proliferator activated receptor alpha	Homo sapiens	0-9
23617751-0	2014	Relationship between neonatal adrenomedullin and bilirubin levels.	Bilirubin	49-58	adrenomedullin	Homo sapiens	30-44
23617751-2	2014	We aimed to investigate the relationship between serum bilirubin and an antioxidant, anti-inflammatory and neuroprotective peptid, adrenomedullin (AM) levels.	Bilirubin	55-64	adrenomedullin	Homo sapiens	131-145
24523126-13	2014	Examples of adaptive nontoxic changes in liver function, which may elevate direct (conjugated) and/or indirect (unconjugated) bilirubin above baseline levels, include reversible inhibition of UGT1A1-mediated bilirubin metabolism and OATP1B1-, OATP1B3-, or MRP2-mediated transport (Keogh.	Bilirubin	126-135	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	192-198
24523126-13	2014	Examples of adaptive nontoxic changes in liver function, which may elevate direct (conjugated) and/or indirect (unconjugated) bilirubin above baseline levels, include reversible inhibition of UGT1A1-mediated bilirubin metabolism and OATP1B1-, OATP1B3-, or MRP2-mediated transport (Keogh.	Bilirubin	208-217	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	192-198
24523126-13	2014	Examples of adaptive nontoxic changes in liver function, which may elevate direct (conjugated) and/or indirect (unconjugated) bilirubin above baseline levels, include reversible inhibition of UGT1A1-mediated bilirubin metabolism and OATP1B1-, OATP1B3-, or MRP2-mediated transport (Keogh.	Bilirubin	208-217	solute carrier organic anion transporter family member 1B1	Homo sapiens	233-240
24523126-13	2014	Examples of adaptive nontoxic changes in liver function, which may elevate direct (conjugated) and/or indirect (unconjugated) bilirubin above baseline levels, include reversible inhibition of UGT1A1-mediated bilirubin metabolism and OATP1B1-, OATP1B3-, or MRP2-mediated transport (Keogh.	Bilirubin	208-217	solute carrier organic anion transporter family member 1B3	Homo sapiens	243-250
24523126-13	2014	Examples of adaptive nontoxic changes in liver function, which may elevate direct (conjugated) and/or indirect (unconjugated) bilirubin above baseline levels, include reversible inhibition of UGT1A1-mediated bilirubin metabolism and OATP1B1-, OATP1B3-, or MRP2-mediated transport (Keogh.	Bilirubin	208-217	ATP binding cassette subfamily C member 2	Homo sapiens	256-260
25147562-2	2014	The present study aimed at evaluating how 3 PPARalpha agonists, namely, fenofibrate, gemfibrozil, and Wy14,643, affect bilirubin synthesis and metabolism.	Bilirubin	119-128	peroxisome proliferator activated receptor alpha	Homo sapiens	44-53
25147562-4	2014	Human hepatocytes (HH) and HepG2 cells sustained similar treatments, except that the expression of the bilirubin conjugating UDP-glucuronosyltransferase (UGT) 1A1 enzyme and multidrug resistance-associated protein (MRP) 2 transporter was analyzed.	Bilirubin	103-112	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	125-162
25147562-9	2014	These observations indicate that PPARalpha ligands activate bilirubin synthesis in vascular cells and metabolism in liver cells.	Bilirubin	60-69	peroxisome proliferator activated receptor alpha	Homo sapiens	33-42
24211270-1	2014	Heme oxygenase (HO)-1 is an oxidative stress-response enzyme which catalyzes the degradation of heme into bilirubin, ferric ion, and carbon monoxide (CO).	Bilirubin	106-115	heme oxygenase 1	Homo sapiens	0-21
24063841-1	2013	Whether conjugated bilirubin concentration, resulting from hepatic UDP-glucuronosyltransferase 1 A1 activity, is associated with cardiovascular disease is unknown.	Bilirubin	19-28	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	67-99
25276901-5	2014	Correlation between ChE activity and serum bilirubin, albumin, PT INR and MELD score (Model for End-Stage Liver Disease) was analysed.	Bilirubin	43-52	butyrylcholinesterase	Homo sapiens	20-23
24140589-17	2013	FSEE significantly prevented CCl4 induced elevation of AST, ALT, ALP, TB, and CCl4 induced decrease in total protein in rats.	Bilirubin	70-72	C-C motif chemokine ligand 4	Rattus norvegicus	29-33
23665585-1	2013	BACKGROUND: Human serum albumin acts as a reservoir and transport protein for endogenous (e.g. fatty acids or bilirubin) and exogenous compounds (e.g. drugs or nutrients) in the blood.	Bilirubin	110-119	albumin	Homo sapiens	18-31
23839159-9	2013	This prognostic value of GGT was further validated in the mass-forming, normal bilirubin, and Child-Pugh A subgroups.	Bilirubin	79-88	gamma-glutamyltransferase light chain family member 3	Homo sapiens	25-28
23796976-4	2013	Total bilirubin (TB) was measured and the association between TB and IFN-gamma, sICAM-1, interleukin-17 were analyzed.	Bilirubin	62-64	interferon gamma	Homo sapiens	69-78
23796976-9	2013	TB levels were positively correlated with IFN-gamma, interleukin-17 and sICAM-1 levels.	Bilirubin	0-2	interferon gamma	Homo sapiens	42-51
24138949-9	2013	We found increased cellular expression of multidrug resistance-associated protein 1 and P-glycoprotein in the hippocampus, known as defensive mechanisms against bilirubin-induced cytotoxicity.	Bilirubin	161-170	ATP binding cassette subfamily C member 1	Homo sapiens	42-83
24138949-9	2013	We found increased cellular expression of multidrug resistance-associated protein 1 and P-glycoprotein in the hippocampus, known as defensive mechanisms against bilirubin-induced cytotoxicity.	Bilirubin	161-170	ATP binding cassette subfamily B member 1	Homo sapiens	88-102
24323422-8	2013	CO activates cGMP to promote vasodilation, and biliverdin is converted to bilirubin which can serve as an anti-oxidant, both of which may contribute to the reported protective role of HO-1 in cerebral ischemia and subarachnoid hemorrhage.	Bilirubin	74-83	heme oxygenase 1	Homo sapiens	184-188
24209691-0	2013	High sensitive C-reactive protein and serum amyloid A are inversely related to serum bilirubin: effect-modification by metabolic syndrome.	Bilirubin	85-94	C-reactive protein	Homo sapiens	15-33
24209691-0	2013	High sensitive C-reactive protein and serum amyloid A are inversely related to serum bilirubin: effect-modification by metabolic syndrome.	Bilirubin	85-94	serum amyloid A1 cluster	Homo sapiens	38-53
24209691-4	2013	We determined relationships of high sensitive C-reactive protein (hs-CRP) and SAA with bilirubin in subjects with and without metabolic syndrome (MetS).	Bilirubin	87-96	C-reactive protein	Homo sapiens	46-64
24209691-4	2013	We determined relationships of high sensitive C-reactive protein (hs-CRP) and SAA with bilirubin in subjects with and without metabolic syndrome (MetS).	Bilirubin	87-96	serum amyloid A1 cluster	Homo sapiens	78-81
24209691-6	2013	RESULTS: Bilirubin was lower in MetS (P = 0.013), coinciding with higher hs-CRP (P &lt; 0.001) and SAA levels (P = 0.002).	Bilirubin	9-18	serum amyloid A1 cluster	Homo sapiens	99-102
24209691-8	2013	The inverse relationship of bilirubin with SAA was confined to subjects without MetS (r = -0.267, P = 0.009).	Bilirubin	28-37	serum amyloid A1 cluster	Homo sapiens	43-46
24209691-9	2013	Furthermore, the presence of either MetS or T2DM modified the relationship of bilirubin with SAA (interaction terms: beta = 0.366, P = 0.003 and beta = 0.289, P = 0.025, respectively) in age- and sex-adjusted analyses.	Bilirubin	78-87	serum amyloid A1 cluster	Homo sapiens	93-96
24209691-11	2013	Of the individual MetS components, the strongest interaction of bilirubin on SAA was observed with low HDL cholesterol (beta = 0.435, P &lt; 0.001).	Bilirubin	64-73	serum amyloid A1 cluster	Homo sapiens	77-80
24209691-13	2013	The inverse relationship of SAA with bilirubin was found to be absent in MetS, which could be attributable to MetS-associated abnormalities in HDL characteristics.	Bilirubin	37-46	serum amyloid A1 cluster	Homo sapiens	28-31
24063924-8	2013	Serum alkaline phosphatase and direct bilirubin correlated with TAPSE and RAP, and were highest in cachectic patients (all p &lt;= 0.002), suggesting cholestatic dysfunction due to liver congestion.	Bilirubin	38-47	LDL receptor related protein associated protein 1	Homo sapiens	74-77
24113378-2	2013	Human biliverdin reductase (hBVR), an enzyme involved in the conversion of biliverdin into bilirubin in heme metabolism, was recently identified as an important cytoprotectant against oxidative stress and hypoxia.	Bilirubin	91-100	biliverdin reductase A	Homo sapiens	28-32
23774522-9	2013	The two alpha-helices, TM2 corroborated in this study, and TM3 confirmed in our previous investigation, provide reasonable building blocks of a potential transmembrane channel for transport of bilirubin and small hydrophilic molecules, including pharmaceutically active compounds.	Bilirubin	193-202	tropomyosin 3	Homo sapiens	59-62
23994036-12	2013	In regard of OCSP subtypes, the highest level of bilirubin was found in TACI, so did the highest rate of elevated bilirubin.	Bilirubin	49-58	TNF receptor superfamily member 13B	Homo sapiens	72-76
23742048-4	2013	METHODS: We used Gunn rat pups, which have a deficiency of the bilirubin-conjugating enzyme UGT1A1.	Bilirubin	63-72	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	92-98
23950218-1	2013	UDP-glucuronosyltransferase (UGT) 1A1 is the sole enzyme that can metabolize bilirubin.	Bilirubin	77-86	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-37
23950218-10	2013	Treatment of humanized UGT1 mice with UVB resulted in a reduction of serum bilirubin levels, along with increased UGT1A1 expression and activity in the skin.	Bilirubin	75-84	UDP glucuronosyltransferase 1 family, polypeptide A2	Mus musculus	23-27
24204915-1	2013	Present study was aimed to explore the effect of (TA)n UGT1A1 gene promoter polymorphism on bilirubin metabolism, bilirubinaemia, predisposition to cholelithiasis and subsequent cholecystectomy, in Sickle-Cell Anemia (SCA) and beta-Thalasemia major (bTH) in Kuwaiti subjects compared to other population.	Bilirubin	92-101	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	55-61
24151358-6	2013	The data show that a substantial fraction of bilirubin conjugates is primarily secreted by MRP3 at the sinusoidal membrane into the blood, from where they are subsequently reuptaken by sinusoidal membrane-bound organic anion transporting polypeptides OATP1B1 and OATP1B3.	Bilirubin	45-54	ATP binding cassette subfamily C member 3	Homo sapiens	91-95
24151358-6	2013	The data show that a substantial fraction of bilirubin conjugates is primarily secreted by MRP3 at the sinusoidal membrane into the blood, from where they are subsequently reuptaken by sinusoidal membrane-bound organic anion transporting polypeptides OATP1B1 and OATP1B3.	Bilirubin	45-54	solute carrier organic anion transporter family member 1B1	Homo sapiens	251-258
24151358-6	2013	The data show that a substantial fraction of bilirubin conjugates is primarily secreted by MRP3 at the sinusoidal membrane into the blood, from where they are subsequently reuptaken by sinusoidal membrane-bound organic anion transporting polypeptides OATP1B1 and OATP1B3.	Bilirubin	45-54	solute carrier organic anion transporter family member 1B3	Homo sapiens	263-270
24104695-2	2013	Here, the impact of fatty acids on human UDP-glucuronosyltransferase (UGT) 1A1--the sole enzyme that can metabolize bilirubin--were examined.	Bilirubin	116-125	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	41-78
24104695-4	2013	Forty-eight hours after a treatment with a lower concentration of DHA (10 mg/kg), total bilirubin significantly increased in neonatal hUGT1 mice, which are human neonatal jaundice models.	Bilirubin	88-97	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	134-139
24104695-5	2013	In contrast, treatments with higher concentrations of fatty acids (0.1-10 g/kg) resulted in a decrease in serum bilirubin in hUGT1 mice.	Bilirubin	112-121	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	125-130
24104695-7	2013	Our data indicates that activation of peroxisome proliferator-activated receptors would increase UGT1A1 expression, resulting in reduction of serum bilirubin levels in human infants.	Bilirubin	148-157	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	97-103
23782005-11	2013	There was a significant association between UGT1A1 genotype and bilirubin grade in the maternal population (p=0.0006) but not neonates (p=0.49).	Bilirubin	64-73	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	44-50
23877636-1	2013	Heme oxygenase-1 (HO-1) is a rate-limiting enzyme in bilirubin metabolism, and its genetic variant may modulate hyperbilirubinemia risk in neonates.	Bilirubin	53-62	heme oxygenase 1	Homo sapiens	0-16
23877636-1	2013	Heme oxygenase-1 (HO-1) is a rate-limiting enzyme in bilirubin metabolism, and its genetic variant may modulate hyperbilirubinemia risk in neonates.	Bilirubin	53-62	heme oxygenase 1	Homo sapiens	18-22
24329858-5	2014	In patients with ACHBLF, TIPE2 mRNA level was positively correlated with serum total bilirubin, international normalized ratio and model for end-stage liver disease scores.	Bilirubin	85-94	TNF alpha induced protein 8 like 2	Homo sapiens	25-30
23998495-8	2013	Positive correlations between PON1 activity and total cholesterol, HDL-C and triglycerides were noted but inverse correlations with FFA, BHB and bilirubin were found indicating that PON1 activity changed with lipid metabolism and was influenced by negative energy balance.	Bilirubin	145-154	paraoxonase 1	Homo sapiens	182-186
23933303-9	2013	The biotinylated bilirubin derivatives show better binding to alpha1 (I) chain rather than alpha2 (I) chains which clearly designates that bilirubin shows greater affinity to alpha1 chains of collagen.	Bilirubin	17-26	adrenoceptor alpha 1D	Homo sapiens	175-181
23947957-1	2013	Crigler-Najjar syndrome type I is caused by mutations of the uridine diphospho-glucuronosyl transferase 1A1 (UGT1A1) gene resulting in life-threatening increase of serum bilirubin.	Bilirubin	170-179	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	61-107
23947957-1	2013	Crigler-Najjar syndrome type I is caused by mutations of the uridine diphospho-glucuronosyl transferase 1A1 (UGT1A1) gene resulting in life-threatening increase of serum bilirubin.	Bilirubin	170-179	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	109-115
23933303-8	2013	Based on the collagen binding assays, the binding of bilirubin to collagen is found to be electrostatic in nature, which confirms binding between the amino acid fragment of alpha1 (I) region of collagen and carboxyl group of bilirubin.	Bilirubin	53-62	adrenoceptor alpha 1D	Homo sapiens	173-179
23933303-8	2013	Based on the collagen binding assays, the binding of bilirubin to collagen is found to be electrostatic in nature, which confirms binding between the amino acid fragment of alpha1 (I) region of collagen and carboxyl group of bilirubin.	Bilirubin	225-234	adrenoceptor alpha 1D	Homo sapiens	173-179
23933303-9	2013	The biotinylated bilirubin derivatives show better binding to alpha1 (I) chain rather than alpha2 (I) chains which clearly designates that bilirubin shows greater affinity to alpha1 chains of collagen.	Bilirubin	17-26	adrenoceptor alpha 1D	Homo sapiens	62-68
23933303-9	2013	The biotinylated bilirubin derivatives show better binding to alpha1 (I) chain rather than alpha2 (I) chains which clearly designates that bilirubin shows greater affinity to alpha1 chains of collagen.	Bilirubin	139-148	adrenoceptor alpha 1D	Homo sapiens	62-68
23401472-1	2013	Human uridine 5"-diphospho-glucuronosyltransferase (UGT) 1A1 catalyzes the metabolism of numerous clinically and pharmacologically important compounds, such as bilirubin and SN-38.	Bilirubin	160-169	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	6-60
24522354-1	2013	BACKGROUND: In Europeans the TATA box TA7 repeat promoter variant in the UGT1A1 gene (UGT1A1*28) is the major determinant of bilirubin levels.	Bilirubin	125-134	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	73-79
23932761-3	2013	Nonetheless, recent Mendelian randomization analyses reveal that individuals who carry low expression alleles of the hepatic bilirubin conjugating enzyme UGT1A1, and hence have somewhat elevated levels of plasma bilirubin throughout life, are not at decreased risk for vascular disorders.	Bilirubin	125-134	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	154-160
23932761-3	2013	Nonetheless, recent Mendelian randomization analyses reveal that individuals who carry low expression alleles of the hepatic bilirubin conjugating enzyme UGT1A1, and hence have somewhat elevated levels of plasma bilirubin throughout life, are not at decreased risk for vascular disorders.	Bilirubin	212-221	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	154-160
23932761-6	2013	Consistent with this view, high expression alleles of the major enzymatic source of bilirubin, heme oxygenase-1 (HO-1), do associate with decreased vascular risk in the majority of studies that have addressed this issue, and increased plasma bilirubin has been reported in carriers of these alleles.	Bilirubin	84-93	heme oxygenase 1	Homo sapiens	95-111
23932761-6	2013	Consistent with this view, high expression alleles of the major enzymatic source of bilirubin, heme oxygenase-1 (HO-1), do associate with decreased vascular risk in the majority of studies that have addressed this issue, and increased plasma bilirubin has been reported in carriers of these alleles.	Bilirubin	242-251	heme oxygenase 1	Homo sapiens	95-111
23932761-8	2013	However, there is good reason to suspect that, at some sufficiently high plasma bilirubin level--as in individuals with very intense Gilbert syndrome or in Gunn rats lacking UGT1A1 activity--the plasma bilirubin pool does indeed provide some antioxidant protection to cells.	Bilirubin	202-211	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	174-180
24522354-1	2013	BACKGROUND: In Europeans the TATA box TA7 repeat promoter variant in the UGT1A1 gene (UGT1A1*28) is the major determinant of bilirubin levels.	Bilirubin	125-134	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	86-92
24065680-2	2013	These mutations result in the deficiency of UGT1A1, a hepatic enzyme essential for bilirubin conjugation.	Bilirubin	83-92	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	44-50
23942037-6	2013	Up-regulation of HO-1 by some compounds resulted in increased cellular bilirubin levels but did not augment the expression of proteins involved in heme synthesis (ALAS 1) or biliverdin reductase.	Bilirubin	71-80	heme oxygenase 1	Mus musculus	17-21
23942037-7	2013	Bilirubin production by HO-1 inducers correlated with their potency in inhibiting nitrite production after challenge with interferon-gamma (INF-gamma) or lipopolysaccharide (LPS).	Bilirubin	0-9	heme oxygenase 1	Mus musculus	24-28
23942037-7	2013	Bilirubin production by HO-1 inducers correlated with their potency in inhibiting nitrite production after challenge with interferon-gamma (INF-gamma) or lipopolysaccharide (LPS).	Bilirubin	0-9	interferon gamma	Mus musculus	122-138
23942037-7	2013	Bilirubin production by HO-1 inducers correlated with their potency in inhibiting nitrite production after challenge with interferon-gamma (INF-gamma) or lipopolysaccharide (LPS).	Bilirubin	0-9	interferon gamma	Mus musculus	140-149
23750830-16	2013	These data suggest that the proposed surrogate probe substrates to evaluate the in vitro inhibition of UGT1A1, OATP1B1, and BSEP may be suitable to assess bilirubin disposition.	Bilirubin	155-164	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	103-109
24098306-13	2013	A new model (NMELD) was proposed with the use of the natural logarithms of two blood serum variables (total bilirubin and albumin) and the patients" age (year) by applying the Cox model: NMELD = 10 x (0.736 x ln (bilirubin) - 1.312 x ln (albumin) + 0.025 x age + 1.776).	Bilirubin	108-117	cytochrome c oxidase subunit 8A	Homo sapiens	176-179
24098306-13	2013	A new model (NMELD) was proposed with the use of the natural logarithms of two blood serum variables (total bilirubin and albumin) and the patients" age (year) by applying the Cox model: NMELD = 10 x (0.736 x ln (bilirubin) - 1.312 x ln (albumin) + 0.025 x age + 1.776).	Bilirubin	213-222	cytochrome c oxidase subunit 8A	Homo sapiens	176-179
23750830-2	2013	Bilirubin elimination is a multifaceted process consisting of uptake of bilirubin into the hepatocytes facilitated by OATP1B1 and OATP1B3.	Bilirubin	0-9	solute carrier organic anion transporter family member 1B1	Homo sapiens	118-125
23750830-2	2013	Bilirubin elimination is a multifaceted process consisting of uptake of bilirubin into the hepatocytes facilitated by OATP1B1 and OATP1B3.	Bilirubin	0-9	solute carrier organic anion transporter family member 1B3	Homo sapiens	130-137
23790331-4	2013	Similarly, compared to the CCl4 control, significant reduction (P&lt;0.05) in serum AST, ALT and bilirubin as well as in level of total cholesterol and MDA with concomitant increase in HDL cholesterol, superoxide dismutase and catalase levels when CCl4-intoxicated rats were treated with Cassia singueana root extract for two weeks.	Bilirubin	97-106	C-C motif chemokine ligand 4	Rattus norvegicus	27-31
23750830-16	2013	These data suggest that the proposed surrogate probe substrates to evaluate the in vitro inhibition of UGT1A1, OATP1B1, and BSEP may be suitable to assess bilirubin disposition.	Bilirubin	155-164	solute carrier organic anion transporter family member 1B1	Homo sapiens	111-118
23750830-2	2013	Bilirubin elimination is a multifaceted process consisting of uptake of bilirubin into the hepatocytes facilitated by OATP1B1 and OATP1B3.	Bilirubin	72-81	solute carrier organic anion transporter family member 1B1	Homo sapiens	118-125
23750830-2	2013	Bilirubin elimination is a multifaceted process consisting of uptake of bilirubin into the hepatocytes facilitated by OATP1B1 and OATP1B3.	Bilirubin	72-81	solute carrier organic anion transporter family member 1B3	Homo sapiens	130-137
23750830-16	2013	These data suggest that the proposed surrogate probe substrates to evaluate the in vitro inhibition of UGT1A1, OATP1B1, and BSEP may be suitable to assess bilirubin disposition.	Bilirubin	155-164	ATP binding cassette subfamily B member 11	Homo sapiens	124-128
23750830-6	2013	However, because drug transporters also contribute to bilirubin elimination, the purpose of this work was to investigate the in vitro inhibition of OATP1B1, OATP1B3, MRP2, and BSEP of select test drugs known to elicit hyperbilirubinemia.	Bilirubin	54-63	ATP binding cassette subfamily B member 11	Homo sapiens	176-180
23560764-6	2013	UDCA (100 muM) neutralized the damaging effects of bilirubin (50 muM) and sera from jaundiced patients on survival.	Bilirubin	51-60	latexin	Homo sapiens	10-13
23695864-12	2013	We concluded that silibinin-induced hyperbilirubinemia may be caused by an inhibition of the bilirubin-transporting OATPs and the efflux-transporter MRP2.	Bilirubin	41-50	ATP binding cassette subfamily C member 2	Homo sapiens	149-153
23722043-0	2013	Biliverdin reductase/bilirubin mediates the anti-apoptotic effect of hypoxia in pulmonary arterial smooth muscle cells through ERK1/2 pathway.	Bilirubin	21-30	biliverdin reductase A	Homo sapiens	0-20
23722043-0	2013	Biliverdin reductase/bilirubin mediates the anti-apoptotic effect of hypoxia in pulmonary arterial smooth muscle cells through ERK1/2 pathway.	Bilirubin	21-30	mitogen-activated protein kinase 3	Homo sapiens	127-133
23722043-7	2013	Our results showed that siBVR, blocking generation of bilirubin, reversed the effect of hypoxia on enhancing cell survival and apoptotic protein (Bcl-2, procasepase-9, procasepase-3) expression, preventing nuclear shrinkage, DNA fragmentation and mitochondrial depolarization in starved PASMCs, which were recovered by exogenous bilirubin.	Bilirubin	54-63	BCL2 apoptosis regulator	Homo sapiens	146-151
23722043-8	2013	Moreover, the inhibitory effect of bilirubin on PASMC apoptosis under hypoxic condition was blocked by the inhibitor of ERK1/2 pathway.	Bilirubin	35-44	mitogen-activated protein kinase 3	Homo sapiens	120-126
23722043-9	2013	Taken together, our data indicate that BVR contributes to the inhibitory process of hypoxia on PASMC apoptosis, which is mediated by bilirubin through ERK1/2 pathway.	Bilirubin	133-142	biliverdin reductase A	Homo sapiens	39-42
23722043-9	2013	Taken together, our data indicate that BVR contributes to the inhibitory process of hypoxia on PASMC apoptosis, which is mediated by bilirubin through ERK1/2 pathway.	Bilirubin	133-142	mitogen-activated protein kinase 3	Homo sapiens	151-157
23615401-8	2013	HO-1 end products, such as carbon monoxide, free iron and bilirubin, suppressed the TPA-induced MMP-9 mRNA and protein expression, enzyme activity, migration and invasion in MCF-7 cells.	Bilirubin	58-67	heme oxygenase 1	Homo sapiens	0-4
23615401-8	2013	HO-1 end products, such as carbon monoxide, free iron and bilirubin, suppressed the TPA-induced MMP-9 mRNA and protein expression, enzyme activity, migration and invasion in MCF-7 cells.	Bilirubin	58-67	matrix metallopeptidase 9	Homo sapiens	96-101
23773695-1	2013	BACKGROUND: Most ADAMTS13 assays use non-physiological conditions (low ionic strength, low pH, barium chloride), are subject to interference from plasma proteins, hemoglobin and bilirubin, and have limited sensitivity, especially for inhibitors.	Bilirubin	178-187	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	17-25
23560764-6	2013	UDCA (100 muM) neutralized the damaging effects of bilirubin (50 muM) and sera from jaundiced patients on survival.	Bilirubin	51-60	latexin	Homo sapiens	65-68
23560764-7	2013	Moreover, UDCA (1 muM and 10 muM) increased osteoblast differentiation in cells treated with harmful concentrations of LCA or bilirubin.	Bilirubin	126-135	latexin	Homo sapiens	18-21
23560764-7	2013	Moreover, UDCA (1 muM and 10 muM) increased osteoblast differentiation in cells treated with harmful concentrations of LCA or bilirubin.	Bilirubin	126-135	latexin	Homo sapiens	29-32
23560764-9	2013	Furthermore, UDCA increased osteoblast mineralization by 35% and neutralized the negative consequences of 50 muM bilirubin.	Bilirubin	113-122	latexin	Homo sapiens	109-112
23926009-1	2013	OBJECTIVE: To analyze potential mutations of uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) gene in patients with unconjugated hyperbilirubinemia, and to explore the correlation between the mutations and total serum bilirubin levels.	Bilirubin	142-151	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	45-92
23926009-1	2013	OBJECTIVE: To analyze potential mutations of uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) gene in patients with unconjugated hyperbilirubinemia, and to explore the correlation between the mutations and total serum bilirubin levels.	Bilirubin	142-151	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	94-100
23926009-8	2013	CONCLUSION: The level of total serum bilirubin is correlated with the number of UGT1A1 gene mutations as well as their heterozygous or homozygous status.	Bilirubin	37-46	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	80-86
23628428-5	2013	In reporter assays, BR treatment of primary hepatocytes transfected with a Cyp2a5 promoter-luciferase reporter construct resulted in a 2-fold induction of Cyp2a5 reporter activity.	Bilirubin	20-22	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	75-81
23578993-11	2013	Serum markers of liver damage (AST, ALT, ALP and Bilirubin) were increased by CCl4 and TAA intoxication (p&lt;0.001), whereas co-treatment with NAC reversed such changes (p&lt;0.001).	Bilirubin	49-58	C-C motif chemokine ligand 4	Rattus norvegicus	78-82
23628428-1	2013	Bilirubin (BR) has recently been identified as the first endogenous substrate for cytochrome P450 2A5 (CYP2A5) and it has been suggested that CYP2A5 plays a major role in BR clearance as an alternative mechanism to BR conjugation by uridine-diphosphate glucuronyltransferase 1A1.	Bilirubin	0-9	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	82-101
23628428-5	2013	In reporter assays, BR treatment of primary hepatocytes transfected with a Cyp2a5 promoter-luciferase reporter construct resulted in a 2-fold induction of Cyp2a5 reporter activity.	Bilirubin	20-22	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	155-161
23628428-1	2013	Bilirubin (BR) has recently been identified as the first endogenous substrate for cytochrome P450 2A5 (CYP2A5) and it has been suggested that CYP2A5 plays a major role in BR clearance as an alternative mechanism to BR conjugation by uridine-diphosphate glucuronyltransferase 1A1.	Bilirubin	0-9	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	103-109
23628428-9	2013	Transient overexpression of CYP2A5 partially blocked BR-induced caspase-3 cleavage in Hepa 1-6 cells.	Bilirubin	53-55	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	28-34
23628428-1	2013	Bilirubin (BR) has recently been identified as the first endogenous substrate for cytochrome P450 2A5 (CYP2A5) and it has been suggested that CYP2A5 plays a major role in BR clearance as an alternative mechanism to BR conjugation by uridine-diphosphate glucuronyltransferase 1A1.	Bilirubin	0-9	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	142-148
23628428-1	2013	Bilirubin (BR) has recently been identified as the first endogenous substrate for cytochrome P450 2A5 (CYP2A5) and it has been suggested that CYP2A5 plays a major role in BR clearance as an alternative mechanism to BR conjugation by uridine-diphosphate glucuronyltransferase 1A1.	Bilirubin	11-13	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	82-101
23628428-9	2013	Transient overexpression of CYP2A5 partially blocked BR-induced caspase-3 cleavage in Hepa 1-6 cells.	Bilirubin	53-55	caspase 3	Mus musculus	64-73
23628428-1	2013	Bilirubin (BR) has recently been identified as the first endogenous substrate for cytochrome P450 2A5 (CYP2A5) and it has been suggested that CYP2A5 plays a major role in BR clearance as an alternative mechanism to BR conjugation by uridine-diphosphate glucuronyltransferase 1A1.	Bilirubin	11-13	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	103-109
23628428-1	2013	Bilirubin (BR) has recently been identified as the first endogenous substrate for cytochrome P450 2A5 (CYP2A5) and it has been suggested that CYP2A5 plays a major role in BR clearance as an alternative mechanism to BR conjugation by uridine-diphosphate glucuronyltransferase 1A1.	Bilirubin	11-13	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	142-148
23628428-10	2013	Furthermore, in vitro degradation of BR was increased by microsomes from Hepa 1-6 cells overexpressing CYP2A5 compared to control cells transfected with an empty vector.	Bilirubin	37-39	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	103-109
23628428-1	2013	Bilirubin (BR) has recently been identified as the first endogenous substrate for cytochrome P450 2A5 (CYP2A5) and it has been suggested that CYP2A5 plays a major role in BR clearance as an alternative mechanism to BR conjugation by uridine-diphosphate glucuronyltransferase 1A1.	Bilirubin	171-173	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	103-109
23628428-1	2013	Bilirubin (BR) has recently been identified as the first endogenous substrate for cytochrome P450 2A5 (CYP2A5) and it has been suggested that CYP2A5 plays a major role in BR clearance as an alternative mechanism to BR conjugation by uridine-diphosphate glucuronyltransferase 1A1.	Bilirubin	171-173	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	142-148
23628428-3	2013	BR induced CYP2A5 expression at the mRNA and protein levels in a dose-dependent manner in primary mouse hepatocytes.	Bilirubin	0-2	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	11-17
23628428-4	2013	BR treatment also caused nuclear translocation of Nuclear factor-E2 p45-related factor 2 (Nrf2) in hepatocytes.	Bilirubin	0-2	nuclear factor, erythroid derived 2, like 2	Mus musculus	50-88
23628428-4	2013	BR treatment also caused nuclear translocation of Nuclear factor-E2 p45-related factor 2 (Nrf2) in hepatocytes.	Bilirubin	0-2	nuclear factor, erythroid derived 2, like 2	Mus musculus	90-94
23482378-1	2013	BACKGROUND: Moderate (approximately 2-fold) increases in plasma unconjugated bilirubin levels are able to attenuate the development of angiotensin II (Ang II)-dependent hypertension.	Bilirubin	77-86	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	135-149
23753274-4	2013	Second, taking advantage of mendelian randomization, we tested whether a genetic variant in the bilirubin glucoronidating enzyme UGT1A1 (rs6742078) was associated with increased plasma bilirubin levels and, in turn, with an increased risk of symptomatic gallstone disease.	Bilirubin	96-105	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	129-135
23753274-4	2013	Second, taking advantage of mendelian randomization, we tested whether a genetic variant in the bilirubin glucoronidating enzyme UGT1A1 (rs6742078) was associated with increased plasma bilirubin levels and, in turn, with an increased risk of symptomatic gallstone disease.	Bilirubin	185-194	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	129-135
23753274-8	2013	UGT1A1 genotype explained 20% of the total variation in plasma bilirubin levels and was associated with increases in the mean plasma bilirubin level overall of +16% (+0.09 mg/dL) in GT heterozygotes and +90% (+0.50 mg/dL) in TT homozygotes compared with GG homozygotes, with similar effects in women and men (P for trend &lt;.001 for all).	Bilirubin	63-72	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
23753274-8	2013	UGT1A1 genotype explained 20% of the total variation in plasma bilirubin levels and was associated with increases in the mean plasma bilirubin level overall of +16% (+0.09 mg/dL) in GT heterozygotes and +90% (+0.50 mg/dL) in TT homozygotes compared with GG homozygotes, with similar effects in women and men (P for trend &lt;.001 for all).	Bilirubin	133-142	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
24060717-0	2013	UGT1A1 promoter polymorphism associated with serum bilirubin level in Saudi patients with sickle cell disease.	Bilirubin	51-60	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
24060717-1	2013	BACKGROUND AND OBJECTIVES: Polymorphism in (TA)n of the UGT1A1 promoter influences bilirubin level and risk of gallstones in patients with sickle cell disease (SCD) of African descent.	Bilirubin	83-92	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	56-62
24060717-8	2013	Increased (TA)n of the UGT1A1 promoter (P &lt; .0001), male gender (P=.02), higher LDH (P=.001), and lower Hb level (P=.009) were associated with higher bilirubin level, while the co-inheritance of a-thalassemia (P=.003) was linked with lower bilirubin level.	Bilirubin	153-162	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	23-29
24060717-8	2013	Increased (TA)n of the UGT1A1 promoter (P &lt; .0001), male gender (P=.02), higher LDH (P=.001), and lower Hb level (P=.009) were associated with higher bilirubin level, while the co-inheritance of a-thalassemia (P=.003) was linked with lower bilirubin level.	Bilirubin	243-252	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	23-29
24060717-12	2013	CONCLUSION: (TA)n in the UGT1A1 promoter and intensity of hemolysis modify steady-state serum bilirubin level in SCD.	Bilirubin	94-103	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	25-31
23606168-5	2013	BCL11A and XmnI polymorphisms had significant effects on baseline HbF, while UGT1A1 promoter polymorphisms significantly influenced baseline serum bilirubin.	Bilirubin	147-156	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	77-83
23482378-1	2013	BACKGROUND: Moderate (approximately 2-fold) increases in plasma unconjugated bilirubin levels are able to attenuate the development of angiotensin II (Ang II)-dependent hypertension.	Bilirubin	77-86	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	151-157
23186341-10	2013	Additionally, serum CTGF was positively correlated with liver stiffness (r = 0.875, P &lt; 0.001) and total bilirubin (r = 0.462, P &lt; 0.001).	Bilirubin	108-117	cellular communication network factor 2	Homo sapiens	20-24
22653321-6	2013	Bilirubin is inversely related to baPWV (R (2) = 0.0032, P = 0.003) and C-reactive protein (CRP) (correlation coefficient = -0.13, P &lt; 0.001).	Bilirubin	0-9	C-reactive protein	Homo sapiens	72-90
23642732-0	2013	Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.	Bilirubin	57-66	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	27-32
23592614-4	2013	Administration of hemin (4 mg/kg body weight) every other day for 4 weeks induced a massive increase in HO-1 expression and activity, as shown by the increased levels of the two main metabolic products of heme degradation, bilirubin and carbon monoxide (CO).	Bilirubin	223-232	heme oxygenase 1	Rattus norvegicus	104-108
22653321-6	2013	Bilirubin is inversely related to baPWV (R (2) = 0.0032, P = 0.003) and C-reactive protein (CRP) (correlation coefficient = -0.13, P &lt; 0.001).	Bilirubin	0-9	C-reactive protein	Homo sapiens	92-95
23414908-7	2013	RESULTS: Serum bilirubin levels were lower in overweight healthy individuals of both sexes, and were negatively associated with abdominal obesity, insulin resistance, fasting glucose, fasting insulin, fasting triglycerides, total cholesterol, low-density lipoprotein cholesterol, and C-reactive protein levels but positively associated with aerobic body capabilities.	Bilirubin	15-24	insulin	Homo sapiens	147-154
22653321-9	2013	Additionally, reduced CRP may be one of mediators on the mechanisms how bilirubin reduces baPWV.	Bilirubin	72-81	C-reactive protein	Homo sapiens	22-25
23414908-7	2013	RESULTS: Serum bilirubin levels were lower in overweight healthy individuals of both sexes, and were negatively associated with abdominal obesity, insulin resistance, fasting glucose, fasting insulin, fasting triglycerides, total cholesterol, low-density lipoprotein cholesterol, and C-reactive protein levels but positively associated with aerobic body capabilities.	Bilirubin	15-24	insulin	Homo sapiens	192-199
23592614-8	2013	Interestingly, HO-1 inhibitor zinc protoporphyrin IX (ZnPP-IX; 1 mg/kg) lowered bilirubin and CO concentrations to control values, thus abolishing all the cardioprotective effects of hemin.	Bilirubin	80-89	heme oxygenase 1	Rattus norvegicus	15-19
24074714-7	2013	In PBC patients, the miR-let-7b expression was significantly correlated with Mayo risk scores (r = -0.4930, P less than 0.001), IL-18 (r = -0.4643, P less than 0.001) and ALP (r = -4119, P less than 0.001), but not with TBIL or GGT.	Bilirubin	220-224	microRNA let-7b	Homo sapiens	25-31
23414908-7	2013	RESULTS: Serum bilirubin levels were lower in overweight healthy individuals of both sexes, and were negatively associated with abdominal obesity, insulin resistance, fasting glucose, fasting insulin, fasting triglycerides, total cholesterol, low-density lipoprotein cholesterol, and C-reactive protein levels but positively associated with aerobic body capabilities.	Bilirubin	15-24	C-reactive protein	Homo sapiens	284-302
24256582-9	2013	There were correlations between GSA-K and total bilirubin, prothrombintime, Child-Pugh score and ICG-K (r = -0.730--0.298, P &lt; 0.05).	Bilirubin	48-57	GNAS complex locus	Homo sapiens	32-35
23578787-3	2013	Heme oxygenase-1 (HO-1) mediates intestinal protection due to anti-inflammatory, antioxidative, and antiapoptotic effects of its products carbon monoxide, biliverdin, and bilirubin.	Bilirubin	171-180	heme oxygenase 1	Mus musculus	0-16
23669654-7	2013	The decreasing trend of CRP levels is encouraging and may be related to the increase in total bilirubin levels.	Bilirubin	94-103	C-reactive protein	Homo sapiens	24-27
23578787-3	2013	Heme oxygenase-1 (HO-1) mediates intestinal protection due to anti-inflammatory, antioxidative, and antiapoptotic effects of its products carbon monoxide, biliverdin, and bilirubin.	Bilirubin	171-180	heme oxygenase 1	Mus musculus	18-22
23537215-0	2013	The association between heterozygosity for UGT1A1*6, UGT1A1*28, and variation in the serum total-bilirubin level in healthy young Japanese adults.	Bilirubin	97-106	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	43-49
23241680-0	2013	Microarray with LNA-probes for genotyping of polymorphic variants of Gilbert"s syndrome gene UGT1A1(TA)n. BACKGROUND: Gilbert"s syndrome is a common metabolic dysfunction characterized by elevated levels of unconjugated bilirubin in the bloodstream.	Bilirubin	220-229	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	93-99
23537215-10	2013	Multiple regression analysis showed significant relationships between the serum total-bilirubin level, the UGT1A1 genotypes *1/*28 and *6/*28, and sex.	Bilirubin	86-95	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	107-113
23537215-12	2013	CONCLUSIONS: We found that the UGT1A1 genotypes *1/*28 and *6/*28 as well as sex contributed to interindividual variations in the serum total-bilirubin levels.	Bilirubin	142-151	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	31-37
23537215-13	2013	In contrast, UGT1A1*1/*6 showed only minimal involvement in individual differences in serum total-bilirubin levels.	Bilirubin	98-107	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	13-19
23801909-1	2013	BACKGROUND: Bilitranslocase (TC 2.A.65.1.1) is a bilirubin-specific membrane transporter, found on absorptive (stomach and intestine) and excretory (kidney and liver) epithelia and in vascular endothelium.	Bilirubin	49-58	ceruloplasmin	Rattus norvegicus	12-27
23647681-1	2013	OBJECTIVES: Interindividual variability in glucuronidation of bilirubin and drugs by UDP-glucuronosyltransferase 1A1 (UGT1A1) is considerable and only partially explained by genetic polymorphisms and enzyme inducers.	Bilirubin	62-71	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	85-116
23647681-1	2013	OBJECTIVES: Interindividual variability in glucuronidation of bilirubin and drugs by UDP-glucuronosyltransferase 1A1 (UGT1A1) is considerable and only partially explained by genetic polymorphisms and enzyme inducers.	Bilirubin	62-71	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	118-124
23647681-7	2013	Exclusion of livers with *28/*28 genotype or alcohol history revealed positive correlations of -4 CpG methylation with bilirubin glucuronidation (R = 0.73, P &lt; 0.00001) and UGT1A1 protein content (R = 0.54, P = 0.008).	Bilirubin	119-128	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	176-182
23296214-8	2013	RESULTS: Sclerostin levels were significantly higher in patients (30.95 +- 18.91 pmol/l) than controls (t = 4.4; P &lt; 0.001), especially in non-HCV patients; they showed an inverse correlation with osteocalcin, prothrombin activity and serum albumin, and a direct correlation with bilirubin and telopeptide, but not with BMD, nutritional status or ethanol intake.	Bilirubin	283-292	sclerostin	Homo sapiens	9-19
23700488-8	2013	However, the Fxr deficient mice displayed significantly increased liver weight, steatosis, hepatocyte ballooning degeneration and lobular inflammation together with elevated plasma levels of ALT, bilirubin and bile acids, findings compatible with non-alcoholic steatohepatitis (NASH) and cholestasis.	Bilirubin	196-205	nuclear receptor subfamily 1, group H, member 4	Mus musculus	13-16
23683031-6	2013	BIL reduced urine Kim-1 in CIN (P &lt; 0.05), while urine NGAL exhibited a decreasing tendency.	Bilirubin	0-3	hepatitis A virus cellular receptor 1	Rattus norvegicus	18-23
23683031-7	2013	In CsA-treated rat kidneys, the protein expression of NOX4 and p22phox was reduced by BIL (P &lt; 0.05).	Bilirubin	86-89	NADPH oxidase 4	Rattus norvegicus	54-58
23683031-7	2013	In CsA-treated rat kidneys, the protein expression of NOX4 and p22phox was reduced by BIL (P &lt; 0.05).	Bilirubin	86-89	cytochrome b-245 alpha chain	Rattus norvegicus	63-70
23704814-6	2013	Total bilirubin was higher in HCC compared with cirrhosis (p&lt;0.01).	Bilirubin	6-15	HCC	Homo sapiens	30-33
23619263-6	2013	IGFBP-3 levels were positively correlated with IGF-I and albumin, and negatively correlated with Child-Pugh, MELD, creatinine, INR, total bilirubin and aPTT ratio.	Bilirubin	138-147	insulin like growth factor binding protein 3	Homo sapiens	0-7
23314852-10	2013	The postoperative serum prothrombin level at the time when the serum bilirubin level was &gt;30 mg/dl was significantly higher in surviving patients (P &lt; 0.01).	Bilirubin	69-78	coagulation factor II, thrombin	Homo sapiens	24-35
23557408-7	2013	DISCUSSION: Biochemical analyses of blood on POD1 enables stratification of patients into low- and high-risk groups for negative outcomes, with serum bilirubin associated with overall and hepatic morbidity and AST associated with mortality.	Bilirubin	150-159	solute carrier family 17 member 5	Homo sapiens	210-213
23619273-3	2013	We analyzed the polymorphism A(TA)&lt;formula&gt;_{n}&lt;/formula&gt; TAA at the UGT1A1 promoter and the relationships between the various A(TA)&lt;formula&gt;_{n}&lt;/formula&gt; TAA genotypes and alleles and bilirubin levels and occurrence of cholelithiasis.	Bilirubin	210-219	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	81-87
23328493-7	2013	Furthermore, the protective effect of DSC on H2O2-induced cell death was abolished by HO-1 inhibitor ZnPP, but was mimicked by carbon monoxide-releasing moiety CORM-3 or HO-1 by-product bilirubin.	Bilirubin	186-195	desmocollin 3	Homo sapiens	38-41
24813317-6	2013	However, the HO/BVR system and its by-products, carbon monoxide and bilirubin, have also been shown to be neuroprotective by activating pro-survival pathways and scavenging free radicals.	Bilirubin	68-77	biliverdin reductase A	Homo sapiens	13-19
23265624-0	2013	Bilirubin participates in protecting of heme oxygenase-1 induction by quercetin against ethanol hepatotoxicity in cultured rat hepatocytes.	Bilirubin	0-9	heme oxygenase 1	Rattus norvegicus	40-56
23403148-5	2013	CO and bilirubin (a downstream product of biliverdin processing) account for the angiogenic, vasodilatory and anti-oxidant properties of HO-1.	Bilirubin	7-16	heme oxygenase 1	Homo sapiens	137-141
23371916-9	2013	More importantly, a significant interaction was found between rs2417940 in SLCO1B3 gene and smoking on total bilirubin levels (P = 1.99 x 10(-3) ).	Bilirubin	109-118	solute carrier organic anion transporter family member 1B3	Homo sapiens	75-82
23371916-10	2013	Single nucleotide polymorphism (SNP) rs2417940 had stronger effects on total bilirubin levels in nonsmokers than in smokers, suggesting that the effects of SLCO1B3 genotype on bilirubin levels were partly dependent on smoking status.	Bilirubin	77-86	solute carrier organic anion transporter family member 1B3	Homo sapiens	156-163
23371916-10	2013	Single nucleotide polymorphism (SNP) rs2417940 had stronger effects on total bilirubin levels in nonsmokers than in smokers, suggesting that the effects of SLCO1B3 genotype on bilirubin levels were partly dependent on smoking status.	Bilirubin	176-185	solute carrier organic anion transporter family member 1B3	Homo sapiens	156-163
23265624-6	2013	Inflammatory challenge of TNF-alpha plus IL-6 further aggravated ethanol-induced oxidative damage, which was also attenuated by bilirubin in part.	Bilirubin	128-137	tumor necrosis factor	Rattus norvegicus	26-35
23265624-6	2013	Inflammatory challenge of TNF-alpha plus IL-6 further aggravated ethanol-induced oxidative damage, which was also attenuated by bilirubin in part.	Bilirubin	128-137	interleukin 6	Rattus norvegicus	41-45
23291409-4	2013	TIM3 -1516 genotypes GT+TT, together with gender, age, ALT, AST, direct bilirubin, albumin and HBeAg status, were associated with HCC compared with cirrhosis patients without HCC (OR, 2.142; P=0.011).	Bilirubin	72-81	hepatitis A virus cellular receptor 2	Homo sapiens	0-4
24138031-7	2013	Indeed, closer in vitro examination employing transporter gene overexpressing MDCK cell lines and membrane vesicles revealed potent compound-dependent inhibition of human multi-drug resistance-associated protein 2 (MRP2/ABCC2; IC50 38 muM) and bile salt export pump (BSEP/ABCB11; IC50 10 muM), two crucial hepatobiliary transport proteins accountable for bilirubin and bile salt homeostasis, respectively.	Bilirubin	355-364	ATP binding cassette subfamily C member 2	Homo sapiens	171-213
24138031-7	2013	Indeed, closer in vitro examination employing transporter gene overexpressing MDCK cell lines and membrane vesicles revealed potent compound-dependent inhibition of human multi-drug resistance-associated protein 2 (MRP2/ABCC2; IC50 38 muM) and bile salt export pump (BSEP/ABCB11; IC50 10 muM), two crucial hepatobiliary transport proteins accountable for bilirubin and bile salt homeostasis, respectively.	Bilirubin	355-364	ATP binding cassette subfamily C member 2	Homo sapiens	215-219
24138031-7	2013	Indeed, closer in vitro examination employing transporter gene overexpressing MDCK cell lines and membrane vesicles revealed potent compound-dependent inhibition of human multi-drug resistance-associated protein 2 (MRP2/ABCC2; IC50 38 muM) and bile salt export pump (BSEP/ABCB11; IC50 10 muM), two crucial hepatobiliary transport proteins accountable for bilirubin and bile salt homeostasis, respectively.	Bilirubin	355-364	ATP binding cassette subfamily C member 2	Homo sapiens	220-225
24138031-7	2013	Indeed, closer in vitro examination employing transporter gene overexpressing MDCK cell lines and membrane vesicles revealed potent compound-dependent inhibition of human multi-drug resistance-associated protein 2 (MRP2/ABCC2; IC50 38 muM) and bile salt export pump (BSEP/ABCB11; IC50 10 muM), two crucial hepatobiliary transport proteins accountable for bilirubin and bile salt homeostasis, respectively.	Bilirubin	355-364	latexin	Homo sapiens	235-238
24138031-7	2013	Indeed, closer in vitro examination employing transporter gene overexpressing MDCK cell lines and membrane vesicles revealed potent compound-dependent inhibition of human multi-drug resistance-associated protein 2 (MRP2/ABCC2; IC50 38 muM) and bile salt export pump (BSEP/ABCB11; IC50 10 muM), two crucial hepatobiliary transport proteins accountable for bilirubin and bile salt homeostasis, respectively.	Bilirubin	355-364	ATP binding cassette subfamily B member 11	Homo sapiens	267-271
24138031-7	2013	Indeed, closer in vitro examination employing transporter gene overexpressing MDCK cell lines and membrane vesicles revealed potent compound-dependent inhibition of human multi-drug resistance-associated protein 2 (MRP2/ABCC2; IC50 38 muM) and bile salt export pump (BSEP/ABCB11; IC50 10 muM), two crucial hepatobiliary transport proteins accountable for bilirubin and bile salt homeostasis, respectively.	Bilirubin	355-364	ATP binding cassette subfamily B member 11	Homo sapiens	272-278
24138031-7	2013	Indeed, closer in vitro examination employing transporter gene overexpressing MDCK cell lines and membrane vesicles revealed potent compound-dependent inhibition of human multi-drug resistance-associated protein 2 (MRP2/ABCC2; IC50 38 muM) and bile salt export pump (BSEP/ABCB11; IC50 10 muM), two crucial hepatobiliary transport proteins accountable for bilirubin and bile salt homeostasis, respectively.	Bilirubin	355-364	latexin	Homo sapiens	288-291
23148825-0	2013	Protein-protein interactions between the bilirubin-conjugating UDP-glucuronosyltransferase UGT1A1 and its shorter isoform 2 regulatory partner derived from alternative splicing.	Bilirubin	41-50	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	91-97
23148825-4	2013	The bilirubin-conjugating UGT1A1 was used as a prototype.	Bilirubin	4-13	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	26-32
23374533-4	2013	CCl4 significantly elevated the levels of lipid peroxidation (MDA), cholesterol, LDL, triglycerides, bilirubin and urea.	Bilirubin	101-110	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
23201824-4	2013	While some evidence indicates that its overexpression affords cellular anti-oxidant protection due to decreased concentrations of its pro-oxidative substrate heme group, and increased bilirubin levels, other reports established that high HO-1 expression and activity may result in a pro-oxidizing atmosphere due to a release of Fe(2+).	Bilirubin	184-193	heme oxygenase 1	Rattus norvegicus	238-242
23388413-2	2013	Among the UGT gene family members, only UGT1A1 is involved in bilirubin conjugation.	Bilirubin	62-71	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	10-13
23388413-2	2013	Among the UGT gene family members, only UGT1A1 is involved in bilirubin conjugation.	Bilirubin	62-71	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	40-46
23243220-4	2013	RESULTS: Humanized OATP1B1, OATP1B3, and OATP1A2 transgenic mice all showed partial or complete rescue of increased plasma bilirubin levels, but also of the increased plasma levels and decreased liver and small intestinal accumulation of methotrexate observed in Slco1a/1b(-/-) mice.	Bilirubin	123-132	solute carrier organic anion transporter family member 1B1	Homo sapiens	19-26
23243220-4	2013	RESULTS: Humanized OATP1B1, OATP1B3, and OATP1A2 transgenic mice all showed partial or complete rescue of increased plasma bilirubin levels, but also of the increased plasma levels and decreased liver and small intestinal accumulation of methotrexate observed in Slco1a/1b(-/-) mice.	Bilirubin	123-132	solute carrier organic anion transporter family member 1B3	Homo sapiens	28-35
23243220-4	2013	RESULTS: Humanized OATP1B1, OATP1B3, and OATP1A2 transgenic mice all showed partial or complete rescue of increased plasma bilirubin levels, but also of the increased plasma levels and decreased liver and small intestinal accumulation of methotrexate observed in Slco1a/1b(-/-) mice.	Bilirubin	123-132	solute carrier organic anion transporter family member 1A2	Homo sapiens	41-48
23130636-2	2013	UGT1A1 (UDP-glucuronosyltransferase 1A1) is a critical gene for bilirubin metabolism and irinotecan detoxification.	Bilirubin	64-73	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
23130636-2	2013	UGT1A1 (UDP-glucuronosyltransferase 1A1) is a critical gene for bilirubin metabolism and irinotecan detoxification.	Bilirubin	64-73	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	8-39
23087099-1	2013	AIMS: Haem oxygenase-1 (HO-1) is a haem-degrading enzyme that generates carbon monoxide, bilirubin, and iron ions.	Bilirubin	89-98	heme oxygenase 1	Mus musculus	6-28
23099118-8	2013	Moreover, increased post-treatment ALT, AST and total bilirubin were associated with GSTM1*1/GSTT1*1 genotypes (p&lt;0.05).	Bilirubin	54-63	glutathione S-transferase mu 1	Homo sapiens	85-92
23099118-8	2013	Moreover, increased post-treatment ALT, AST and total bilirubin were associated with GSTM1*1/GSTT1*1 genotypes (p&lt;0.05).	Bilirubin	54-63	glutathione S-transferase theta 1	Homo sapiens	93-98
23147267-0	2013	UDP-glucuronosyltransferase 1A1 (UGT1A1) gene haplotypes and their effect on serum bilirubin concentration in healthy Indian adults.	Bilirubin	83-92	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-31
23147267-0	2013	UDP-glucuronosyltransferase 1A1 (UGT1A1) gene haplotypes and their effect on serum bilirubin concentration in healthy Indian adults.	Bilirubin	83-92	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	33-39
23147267-1	2013	The aim of the present study was to investigate the allele and genotype frequencies and haplotype structures of the variants in the UGT1A1 gene and their association with serum bilirubin levels in healthy adults.	Bilirubin	177-186	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	132-138
23147267-7	2013	Promoter polymorphisms and a common haplotype of the UGT1A1 gene are associated with serum bilirubin concentrations and could be a genetic risk factor for hyperbilirubinemia in Indians.	Bilirubin	91-100	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	53-59
22750996-9	2013	We focused on the serum alkaline phosphatase/total bilirubin ratio (ALP/TB) at the onset of hyperbilirubinemia and found that it significantly predicted the recovery from hyperbilirubinemia.	Bilirubin	51-60	ATHS	Homo sapiens	68-74
22934695-12	2013	The baseline serum total bilirubin was elevated in UGT1A1*28, *93 allele carriers and *60 homozygote, but with no relationship with severe toxicities.	Bilirubin	25-34	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	51-57
22982575-7	2013	Using mice deficient in Oatp1a/1b and in the multispecific sinusoidal export pump Abcc3, we found that Abcc3 secretes bilirubin conjugates into the blood, while Oatp1a/1b transporters mediate their hepatic re uptake.	Bilirubin	118-127	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	82-87
22982575-7	2013	Using mice deficient in Oatp1a/1b and in the multispecific sinusoidal export pump Abcc3, we found that Abcc3 secretes bilirubin conjugates into the blood, while Oatp1a/1b transporters mediate their hepatic re uptake.	Bilirubin	118-127	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	103-108
22982575-10	2013	Thus, disruption of hepatic reuptake of bilirubin glucuronide due to coexisting OATP1B1 and OATP1B3 deficiencies explains Rotor-type hyperbilirubinemia.Moreover, OATP1B1 and OATP1B3 null mutations may confer substantial drug toxicity risks.	Bilirubin	40-49	solute carrier organic anion transporter family member 1B1	Homo sapiens	80-87
22982575-10	2013	Thus, disruption of hepatic reuptake of bilirubin glucuronide due to coexisting OATP1B1 and OATP1B3 deficiencies explains Rotor-type hyperbilirubinemia.Moreover, OATP1B1 and OATP1B3 null mutations may confer substantial drug toxicity risks.	Bilirubin	40-49	solute carrier organic anion transporter family member 1B3	Homo sapiens	92-99
22982575-10	2013	Thus, disruption of hepatic reuptake of bilirubin glucuronide due to coexisting OATP1B1 and OATP1B3 deficiencies explains Rotor-type hyperbilirubinemia.Moreover, OATP1B1 and OATP1B3 null mutations may confer substantial drug toxicity risks.	Bilirubin	40-49	solute carrier organic anion transporter family member 1B1	Homo sapiens	162-169
22982575-10	2013	Thus, disruption of hepatic reuptake of bilirubin glucuronide due to coexisting OATP1B1 and OATP1B3 deficiencies explains Rotor-type hyperbilirubinemia.Moreover, OATP1B1 and OATP1B3 null mutations may confer substantial drug toxicity risks.	Bilirubin	40-49	solute carrier organic anion transporter family member 1B3	Homo sapiens	174-181
23443766-7	2013	IL-1beta concentration was significantly lower in early TAT-NBD intervention group (15.348-+0.812 pg/ml) than in bilirubin group (P&lt;0.05).	Bilirubin	113-122	interleukin 1 beta	Rattus norvegicus	0-8
23089802-1	2013	Human UDP-glucuronosyltransferase (UGT) 1A1 is the enzyme that detoxifies neurotoxic bilirubin by conjugating it with glucuronic acid.	Bilirubin	85-94	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	6-43
23092328-6	2013	HO-1 is a heme-degrading enzyme generating carbon monoxide, iron, and biliverdin/bilirubin, while BCRP is a heme efflux transporter.	Bilirubin	81-90	heme oxygenase 1	Homo sapiens	0-4
23092328-11	2013	Also cells treated with the anti-oxidants N-acetylcysteine or HO-effector molecule bilirubin showed protection against heme insults, which may explain the increased protection by HO-1 compared to BCRP.	Bilirubin	83-92	heme oxygenase 1	Homo sapiens	179-183
23092328-11	2013	Also cells treated with the anti-oxidants N-acetylcysteine or HO-effector molecule bilirubin showed protection against heme insults, which may explain the increased protection by HO-1 compared to BCRP.	Bilirubin	83-92	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	196-200
22915054-6	2013	Ballooning degenerations and an increase in lipid droplets in liver parenchyma and increases in serum alanine transaminase, aspartate transaminase, and bilirubin were found in the CCl4 group.	Bilirubin	152-161	C-C motif chemokine ligand 4	Rattus norvegicus	180-184
22805420-7	2013	UGT1A1 rs6742078 TT versus GG genotype was associated with 95% increased bilirubin levels (P &lt; 0.001); TT versus GG genotype was associated with odds ratios (ORs) of 1.03 (95% CI, 0.96-1.11; P = 0.73) for IHD and 1.01 (95% CI, 0.92-1.12; P = 0.68) for MI.	Bilirubin	73-82	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
23291671-7	2013	When we performed multivariate analyses to determine the independent predictors of CIMT and hair whitening, CIMT was found to be related to age, waist circumference, the levels of uric acid, bilirubin and gamma-glutamyl transpeptidase, the presence of a family history of CAD and hair whitening, while hair whitening was found to be related to age, hypertension, the bilirubin level and CIMT.	Bilirubin	191-200	CIMT	Homo sapiens	108-112
23291671-7	2013	When we performed multivariate analyses to determine the independent predictors of CIMT and hair whitening, CIMT was found to be related to age, waist circumference, the levels of uric acid, bilirubin and gamma-glutamyl transpeptidase, the presence of a family history of CAD and hair whitening, while hair whitening was found to be related to age, hypertension, the bilirubin level and CIMT.	Bilirubin	191-200	CIMT	Homo sapiens	108-112
23291671-7	2013	When we performed multivariate analyses to determine the independent predictors of CIMT and hair whitening, CIMT was found to be related to age, waist circumference, the levels of uric acid, bilirubin and gamma-glutamyl transpeptidase, the presence of a family history of CAD and hair whitening, while hair whitening was found to be related to age, hypertension, the bilirubin level and CIMT.	Bilirubin	367-376	CIMT	Homo sapiens	108-112
23291671-7	2013	When we performed multivariate analyses to determine the independent predictors of CIMT and hair whitening, CIMT was found to be related to age, waist circumference, the levels of uric acid, bilirubin and gamma-glutamyl transpeptidase, the presence of a family history of CAD and hair whitening, while hair whitening was found to be related to age, hypertension, the bilirubin level and CIMT.	Bilirubin	367-376	CIMT	Homo sapiens	108-112
23041223-12	2012	The serum levels of ALT, AST, and TBIL were significantly lower in the SA-B treatment groups than in the M group.	Bilirubin	34-38	SH3-domain binding protein 5	Rattus norvegicus	71-75
23279060-1	2013	AIMS: The aim of the study was to evaluate the significance of total bilirubin, aspartate transaminase (AST), alanine transaminase and gamma-glutamyltransferase (GGT) for predicting outcome in sepsis-associated cholestasis.	Bilirubin	69-78	gamma-glutamyltransferase light chain family member 3	Homo sapiens	162-165
23182920-9	2013	Bilirubin increased basal production of IL-8 and IL-1beta, but downregulated LPS-induced generation of IL-8 and MIP-1beta.	Bilirubin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
23182920-9	2013	Bilirubin increased basal production of IL-8 and IL-1beta, but downregulated LPS-induced generation of IL-8 and MIP-1beta.	Bilirubin	0-9	interleukin 1 beta	Homo sapiens	49-57
23182920-9	2013	Bilirubin increased basal production of IL-8 and IL-1beta, but downregulated LPS-induced generation of IL-8 and MIP-1beta.	Bilirubin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
23182920-9	2013	Bilirubin increased basal production of IL-8 and IL-1beta, but downregulated LPS-induced generation of IL-8 and MIP-1beta.	Bilirubin	0-9	C-C motif chemokine ligand 4	Homo sapiens	112-121
23182920-11	2013	We observed an unexpected bilirubin-induced increase in gene expression of NOX-1 in LPS-activated cells, and of COX-2 in both resting and activated cells.	Bilirubin	26-35	NADPH oxidase 1	Homo sapiens	75-80
23182920-11	2013	We observed an unexpected bilirubin-induced increase in gene expression of NOX-1 in LPS-activated cells, and of COX-2 in both resting and activated cells.	Bilirubin	26-35	prostaglandin-endoperoxide synthase 2	Homo sapiens	112-117
23781295-5	2013	The heme metabolites including bilirubin converted from biliverdin have overall an anti-inflammatory effect and thus reinforce the anti-inflammatory efficacy of the Hp-CD163-HO-1 pathway.	Bilirubin	31-40	CD163 molecule	Homo sapiens	168-173
23160902-7	2013	Significant linear correlations were observed between the apelin mRNA level and liver fibrosis, serum total bilirubin and the grade of esophageal varices.	Bilirubin	108-117	apelin	Homo sapiens	58-64
23335984-7	2013	High levels of alanine transaminase, aspartate transaminase, bilirubin, prothrombin activity and mortality rates also decreased in rats treated with MGP.	Bilirubin	61-70	matrix Gla protein	Rattus norvegicus	149-152
23413565-6	2012	The administered methanol extracts with the highest antioxidant potential showed a significant dose-dependent hepatoprotective action against CCl4-induced liver damage in both decreasing the levels of liver transaminases and bilirubin and in reducing the extent of morphological malformations of the liver.	Bilirubin	225-234	C-C motif chemokine ligand 4	Rattus norvegicus	142-146
23811769-7	2013	Recently, we found that hyperbilirubinemia, which occurs in some disease states, increased intestinal accumulation and toxicity of methotrexate, an MRP substrate, because of the suppression of MRP function by high plasma concentrations of conjugated bilirubin.	Bilirubin	29-38	ATP binding cassette subfamily C member 1	Homo sapiens	148-151
23811769-7	2013	Recently, we found that hyperbilirubinemia, which occurs in some disease states, increased intestinal accumulation and toxicity of methotrexate, an MRP substrate, because of the suppression of MRP function by high plasma concentrations of conjugated bilirubin.	Bilirubin	29-38	ATP binding cassette subfamily C member 1	Homo sapiens	193-196
22954695-6	2012	For instance, inhibitors could interfere with several normal physiological processes mediated by OATP1B3 (i.e., bile acid reuptake, bilirubin uptake, etc) or cause potential, as-yet unknown, drug interactions by barring hepatic uptake, subsequent metabolism and elimination.	Bilirubin	132-141	solute carrier organic anion transporter family member 1B3	Homo sapiens	97-104
22476862-2	2012	This study was designed to estimate the effects of ciprofibrate simultaneously on rat hepatic bilirubin glucuronoconjugation and on hepatic expression of UGT1A1, UGT1A2 and UGT1A5, all of which belong to the bilirubin cluster.	Bilirubin	208-217	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	154-160
22444871-6	2012	This effect is suppressed by the pharmacological inhibition of HO-1 and mimicked by the end-products of HO activity, i.e., bilirubin and carbon monoxide.	Bilirubin	123-132	heme oxygenase 1	Homo sapiens	63-67
22767413-7	2012	In grafts suffering from rejection, CXCL10 increased significantly (P = 0.008 versus the reference group and P = 0.002 versus the ischemia group) 2 to 5 days before increases in circulating alanine aminotransferase and bilirubin levels.	Bilirubin	219-228	C-X-C motif chemokine ligand 10	Homo sapiens	36-42
22707385-0	2012	ER stress, mitochondrial dysfunction and calpain/JNK activation are involved in oligodendrocyte precursor cell death by unconjugated bilirubin.	Bilirubin	133-142	mitogen-activated protein kinase 8	Homo sapiens	49-52
23065530-4	2012	DNA sequencing using polymerase chain reaction amplification of the ABCC2 gene revealed the patient to have a compound heterozygous variant of MRP2, a molecule involved in canalicular transport of bilirubin.	Bilirubin	197-206	ATP binding cassette subfamily C member 2	Homo sapiens	68-73
22995569-9	2012	Tissue inhibitor of metalloproteinase-1 expression was lower in the bilirubin vs antibiotic group.	Bilirubin	68-77	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	0-39
23207817-1	2012	Bilirubin is conjugated with glucoronic acid in the liver by UDP-glucuronosyltransferase 1A1 (UGT1A1).	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	61-92
23065530-4	2012	DNA sequencing using polymerase chain reaction amplification of the ABCC2 gene revealed the patient to have a compound heterozygous variant of MRP2, a molecule involved in canalicular transport of bilirubin.	Bilirubin	197-206	ATP binding cassette subfamily C member 2	Homo sapiens	143-147
23207817-1	2012	Bilirubin is conjugated with glucoronic acid in the liver by UDP-glucuronosyltransferase 1A1 (UGT1A1).	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	94-100
22859313-12	2012	Similar subcellular targeting and coordination of CYP2A5 and HMOX1 responses suggest favorable conditions for enhanced CYP2A5-mediated bilirubin maintenance in altered heme homeostasis that predisposes to oxidative stress.	Bilirubin	135-144	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	50-56
22917771-5	2012	We show that human MRP2 is able to compensate functionally for the loss of the mouse transporter as demonstrated by comparable bilirubin levels in the humanized mice and wild-type controls, in contrast to the hyperbilirubinemia phenotype that is observed in MRP2(-/-) mice.	Bilirubin	127-136	ATP binding cassette subfamily C member 2	Homo sapiens	19-23
22859313-0	2012	Heme and heme biosynthesis intermediates induce heme oxygenase-1 and cytochrome P450 2A5, enzymes with putative sequential roles in heme and bilirubin metabolism: different requirement for transcription factor nuclear factor erythroid- derived 2-like 2.	Bilirubin	141-150	heme oxygenase 1	Mus musculus	48-64
22648071-10	2012	Furthermore, bilirubin and beta-estradiol, probe substrates for UGT1A1, significantly inhibited the formation of puerarin-7-O-glucuronide in HLMs.	Bilirubin	13-22	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	64-70
22902304-11	2012	The risk genotype of IL1beta and TGFbeta1 also influences the total bilirubin, albumin and alanine aminotransferase levels among alcoholic "Bengalis".	Bilirubin	68-77	interleukin 1 beta	Homo sapiens	21-28
22902304-11	2012	The risk genotype of IL1beta and TGFbeta1 also influences the total bilirubin, albumin and alanine aminotransferase levels among alcoholic "Bengalis".	Bilirubin	68-77	transforming growth factor beta 1	Homo sapiens	33-41
22859313-0	2012	Heme and heme biosynthesis intermediates induce heme oxygenase-1 and cytochrome P450 2A5, enzymes with putative sequential roles in heme and bilirubin metabolism: different requirement for transcription factor nuclear factor erythroid- derived 2-like 2.	Bilirubin	141-150	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	69-88
22859313-1	2012	Cytochrome P450 2A5 (CYP2A5) oxidizes bilirubin to biliverdin and represents a putative candidate for maintaining bilirubin at safe but adequate antioxidant levels.	Bilirubin	38-47	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	0-19
22859313-1	2012	Cytochrome P450 2A5 (CYP2A5) oxidizes bilirubin to biliverdin and represents a putative candidate for maintaining bilirubin at safe but adequate antioxidant levels.	Bilirubin	38-47	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	21-27
22859313-1	2012	Cytochrome P450 2A5 (CYP2A5) oxidizes bilirubin to biliverdin and represents a putative candidate for maintaining bilirubin at safe but adequate antioxidant levels.	Bilirubin	114-123	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	0-19
22859313-1	2012	Cytochrome P450 2A5 (CYP2A5) oxidizes bilirubin to biliverdin and represents a putative candidate for maintaining bilirubin at safe but adequate antioxidant levels.	Bilirubin	114-123	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	21-27
23092212-4	2012	This study evaluated the effect modification of bilirubin and coffee consumption on the association of serum GGT with glycated hemoglobin (HbA1c) and the combined effect of bilirubin and coffee on HbA1c concentrations.	Bilirubin	48-57	gamma-glutamyltransferase light chain family member 3	Homo sapiens	109-112
23092212-10	2012	Both men and women with high bilirubin had consistently lower concentrations of HbA1c across the GGT quartiles.	Bilirubin	29-38	gamma-glutamyltransferase light chain family member 3	Homo sapiens	97-100
22859313-12	2012	Similar subcellular targeting and coordination of CYP2A5 and HMOX1 responses suggest favorable conditions for enhanced CYP2A5-mediated bilirubin maintenance in altered heme homeostasis that predisposes to oxidative stress.	Bilirubin	135-144	heme oxygenase 1	Mus musculus	61-66
22859313-12	2012	Similar subcellular targeting and coordination of CYP2A5 and HMOX1 responses suggest favorable conditions for enhanced CYP2A5-mediated bilirubin maintenance in altered heme homeostasis that predisposes to oxidative stress.	Bilirubin	135-144	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	119-125
23108751-3	2012	Bilirubin fluctuated at high values, between 30.0 and 52.3 mg/dL, transaminases were slightly increased, on admission ALT = 46 U/L and AST = 87 U/L; coagulation indices and serum proteins were on the lower limit of the normal range with PT 68% and albumin = 2.5 g/dL.	Bilirubin	0-9	solute carrier family 17 member 5	Homo sapiens	135-138
22820246-2	2012	For examples: (i) bilirubin is solely conjugated by UGT1A1 and activates its transcription factors Ah receptor, PXR and CAR.	Bilirubin	18-27	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	52-58
22820246-2	2012	For examples: (i) bilirubin is solely conjugated by UGT1A1 and activates its transcription factors Ah receptor, PXR and CAR.	Bilirubin	18-27	aryl hydrocarbon receptor	Homo sapiens	99-110
22820246-2	2012	For examples: (i) bilirubin is solely conjugated by UGT1A1 and activates its transcription factors Ah receptor, PXR and CAR.	Bilirubin	18-27	CXADR pseudogene 1	Homo sapiens	120-123
22212955-0	2012	Association of serum bilirubin and promoter variations in HMOX1 and UGT1A1 genes with sporadic colorectal cancer.	Bilirubin	21-30	heme oxygenase 1	Homo sapiens	58-63
22212955-0	2012	Association of serum bilirubin and promoter variations in HMOX1 and UGT1A1 genes with sporadic colorectal cancer.	Bilirubin	21-30	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	68-74
22829544-1	2012	Human UDP-glucuronosyltransferase (UGT) 1A1 is a critical enzyme responsible for detoxification and metabolism of endogenous and exogenous lipophilic compounds such as bilirubin.	Bilirubin	168-177	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	6-43
22805515-4	2012	The cRL donors had higher postoperative peak level of INR (1.84 vs. 1.62; P = 0.022), and bilirubin (3.37 mg/dl vs. 2.74 mg/dl; P = 0.065) than the mRL donors.	Bilirubin	90-99	interleukin 31 receptor A	Homo sapiens	4-7
23091796-9	2012	Elevated CRP levels were associated with the highest risk for complicated appendicitis (hazard ratio [HR], 2.53; 95% confidence interval [CI], 1.38 to 4.65) followed by WBC (HR, 2.42; 95% CI, 1.07 to 5.46) and bilirubin (HR, 2.04; 95% CI, 1.09 to 3.82).	Bilirubin	210-219	C-reactive protein	Homo sapiens	9-12
22676252-7	2012	Hepcidin also correlated positively with serum ferritin concentration, transferrin saturation, ALT, serum albumin and haemoglobin, but negatively with serum bilirubin.	Bilirubin	157-166	hepcidin antimicrobial peptide	Homo sapiens	0-8
22212955-1	2012	Heme oxygenase-1 (HMOX1) and bilirubin UDP-glucuronosyltransferase (UGT1A1) enzymes, both involved in bilirubin homeostasis, play an important role in the oxidative stress defense.	Bilirubin	29-38	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	68-74
22881289-2	2012	The stress protein, HO-1 mediates the degradation of cellular heme to biliverdin/bilirubin, free iron, and CO and is up-regulated in the brains of persons with Alzheimer"s disease and Parkinson"s disease.	Bilirubin	81-90	heme oxygenase 1	Homo sapiens	20-24
22677050-4	2012	The tryptophan fluorescence quenching measurements revealed that haem metabolites such as haemin, biliverdin and bilirubin bind to L-PGDS with significantly higher affinities than the other small lipophilic ligands examined, showing dissociation constant (K(d)) values from 17.0 to 20.9 nM.	Bilirubin	113-122	prostaglandin D2 synthase	Homo sapiens	131-137
22661571-5	2012	RESULTS: At baseline, UGT1A1 heterozygous and homozygous patients had significantly higher bilirubin levels than wild-type (P = 0.012 and P &lt; 0.001, respectively).	Bilirubin	91-100	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	22-28
22050734-3	2012	Some protease inhibitors (mainly atazanavir and indinavir) act as inhibitors of uridine diphosphate-glucuronosyltransferase (UGT1A1), the enzyme responsible for hepatic conjugation of bilirubin.	Bilirubin	184-193	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	80-123
22050734-3	2012	Some protease inhibitors (mainly atazanavir and indinavir) act as inhibitors of uridine diphosphate-glucuronosyltransferase (UGT1A1), the enzyme responsible for hepatic conjugation of bilirubin.	Bilirubin	184-193	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	125-131
22050734-4	2012	Variations in the promoter region of the UGT1A1 gene (UGT1A1*28, rs8175347) can influence bilirubin plasma levels, modulating the susceptibility to hyperbilirubinemia.	Bilirubin	90-99	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	41-47
22050734-4	2012	Variations in the promoter region of the UGT1A1 gene (UGT1A1*28, rs8175347) can influence bilirubin plasma levels, modulating the susceptibility to hyperbilirubinemia.	Bilirubin	90-99	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	54-60
22791669-8	2012	OUTCOMES: Significant jaundice defined as requirement of phototherapy/exchange transfusion as per hour specific total serum bilirubin (TSB) nomogram of AAP guidelines.	Bilirubin	124-133	serpin family F member 2	Homo sapiens	152-155
22546842-5	2012	Adjuvant phototherapy to prevent brain damage reduces serum unconjugated bilirubin (UCB) levels in CN I patients to the level seen in the milder form of the disease, CN type II.	Bilirubin	73-82	5'-nucleotidase, cytosolic IA	Homo sapiens	99-103
22520641-9	2012	RESULTS: US-FLI showed a positive correlation with HOMA, insulin, uric acid, ferritin, ALT and bilirubin and was associated with steatosis extent assessed histologically and histological features of NASH, except for fibrosis.	Bilirubin	95-104	FLII actin remodeling protein	Homo sapiens	12-15
22749334-0	2012	Effects of statin treatments and polymorphisms in UGT1A1 and SLCO1B1 on serum bilirubin levels in Chinese patients with hypercholesterolaemia.	Bilirubin	78-87	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	50-56
22749334-0	2012	Effects of statin treatments and polymorphisms in UGT1A1 and SLCO1B1 on serum bilirubin levels in Chinese patients with hypercholesterolaemia.	Bilirubin	78-87	solute carrier organic anion transporter family member 1B1	Homo sapiens	61-68
22749334-2	2012	The organic anion transporting polypeptide 1B1 (OATP1B1, gene SLCO1B1) and UDP-glucuronosyltransferase 1A1 (UGT1A1) play an important role in the disposition of bilirubin.	Bilirubin	161-170	solute carrier organic anion transporter family member 1B1	Homo sapiens	4-46
22749334-2	2012	The organic anion transporting polypeptide 1B1 (OATP1B1, gene SLCO1B1) and UDP-glucuronosyltransferase 1A1 (UGT1A1) play an important role in the disposition of bilirubin.	Bilirubin	161-170	solute carrier organic anion transporter family member 1B1	Homo sapiens	48-55
22749334-2	2012	The organic anion transporting polypeptide 1B1 (OATP1B1, gene SLCO1B1) and UDP-glucuronosyltransferase 1A1 (UGT1A1) play an important role in the disposition of bilirubin.	Bilirubin	161-170	solute carrier organic anion transporter family member 1B1	Homo sapiens	62-69
22749334-2	2012	The organic anion transporting polypeptide 1B1 (OATP1B1, gene SLCO1B1) and UDP-glucuronosyltransferase 1A1 (UGT1A1) play an important role in the disposition of bilirubin.	Bilirubin	161-170	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	75-106
22749334-2	2012	The organic anion transporting polypeptide 1B1 (OATP1B1, gene SLCO1B1) and UDP-glucuronosyltransferase 1A1 (UGT1A1) play an important role in the disposition of bilirubin.	Bilirubin	161-170	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	108-114
22749334-4	2012	METHODS: Associations between common polymorphisms in UGT1A1 and SLCO1B1 and the serum bilirubin levels on no lipid-lowering treatment were analyzed in 379 Chinese patients with hypercholesterolaemia.	Bilirubin	87-96	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	54-60
22749334-4	2012	METHODS: Associations between common polymorphisms in UGT1A1 and SLCO1B1 and the serum bilirubin levels on no lipid-lowering treatment were analyzed in 379 Chinese patients with hypercholesterolaemia.	Bilirubin	87-96	solute carrier organic anion transporter family member 1B1	Homo sapiens	65-72
22749334-6	2012	RESULTS: The UGT1A1 polymorphisms associated with reduced enzyme activity were significantly associated with increased baseline bilirubin levels.	Bilirubin	128-137	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	13-19
22749334-9	2012	CONCLUSIONS: This study showed that the polymorphisms in UGT1A1, but not SLCO1B1, were associated with serum bilirubin levels in Chinese patients.	Bilirubin	109-118	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	57-63
22823425-1	2012	Human biliverdin-IXalpha reductase (hBVR-A) catalyzes the conversion of biliverdin-IXalpha to bilirubin-IXalpha in the last step of heme degradation and is a key enzyme in regulating a wide range of cellular responses.	Bilirubin	94-103	biliverdin reductase A	Homo sapiens	6-34
22823425-1	2012	Human biliverdin-IXalpha reductase (hBVR-A) catalyzes the conversion of biliverdin-IXalpha to bilirubin-IXalpha in the last step of heme degradation and is a key enzyme in regulating a wide range of cellular responses.	Bilirubin	94-103	biliverdin reductase A	Homo sapiens	36-42
22324395-8	2012	Induction of Mrp2 by diabetes was in parallel with the increase in bile flow, levels of biliary and plasma total bile acid (TBA), and plasma conjugated bilirubin in DM rats.	Bilirubin	152-161	ATP binding cassette subfamily C member 2	Rattus norvegicus	13-17
22683349-11	2012	Moreover, bilirubin, an antioxidant and physiologic product of HO-1, is protective against mitochondrial oxidative stress.	Bilirubin	10-19	heme oxygenase 1	Homo sapiens	63-67
22324395-9	2012	Diabetes may enhance Mrp2 function and expression in liver, kidney and intestine, which might be due to insulin deficiency, increased TBA and conjugated bilirubin.	Bilirubin	153-162	ATP binding cassette subfamily C member 2	Rattus norvegicus	21-25
22584576-1	2012	Human biliverdin reductase (hBVR), a Ser/Thr/Tyr kinase, inhibits apoptosis by reducing biliverdin-IX to antioxidant bilirubin.	Bilirubin	117-126	biliverdin reductase A	Homo sapiens	28-32
23930103-6	2013	RESULTS: At doses from 17.1 to 513mumol/L, bilirubin dose-dependently enhanced cell viability and colony-formation rates when cells were seeded at either high- or low- densities (all p&lt;0.05 vs. solvent group) accompanied with enhanced intercellular fluorescence transmission and increased Cx43 protein expression in high-density cells.	Bilirubin	43-52	gap junction protein, alpha 1	Rattus norvegicus	292-296
22584576-12	2012	Biliverdin noncovalently inhibited PKCdelta, whereas PKCdelta potentiated hBVR reductase activity and accelerated the rate of bilirubin formation.	Bilirubin	126-135	protein kinase C delta	Homo sapiens	53-61
22334397-7	2012	On the contrary, in mice resistant to experimental BA, CD25+ cell depletion aggravated bile duct injury at 12 dpi after RRV inoculation, as plasma bilirubin levels were elevated by &gt;20-fold compared with nondepleted infected controls.	Bilirubin	147-156	interleukin 2 receptor, alpha chain	Mus musculus	55-59
22521734-5	2012	The up-regulation of Mrp2 and Oat1 was associated with a concomitant increase in urinary BIL after treatment with JBP485 in ANIT-treated rats.	Bilirubin	89-92	ATP binding cassette subfamily C member 2	Rattus norvegicus	21-25
22366465-5	2012	Moreover, conjugated bilirubin and total bile acid in the serum were significantly reduced in patients with high MRP expression compared to patients with low expression.	Bilirubin	21-30	ATP binding cassette subfamily C member 1	Homo sapiens	113-116
22380706-4	2012	RESULTS:   Compared to the control and M-BCAA groups, the LES-BCAA group experienced a rapid and significant improvement in albumin and total serum bilirubin levels and in CPS that began during the initial post-RFA period.	Bilirubin	148-157	AT-rich interaction domain 4B	Homo sapiens	58-66
22027508-6	2012	However, NVP2 significantly (p &lt; 0.05) increased the relative weight of liver, level of serum total bilirubin and activities of gamma-glutamyl transferase, alanine and aspartate aminotransferases.	Bilirubin	103-112	hippocalcin-like 4	Rattus norvegicus	9-13
22521734-5	2012	The up-regulation of Mrp2 and Oat1 was associated with a concomitant increase in urinary BIL after treatment with JBP485 in ANIT-treated rats.	Bilirubin	89-92	solute carrier family 22 member 6	Rattus norvegicus	30-34
22278680-13	2012	Keratin7 expression provided additional discrimination potential to the age, bilirubin, international normalization ratio, creatinine (ABIC) score.	Bilirubin	77-86	keratin 7	Homo sapiens	0-8
22409346-3	2012	R-R2 showed no significant correlation with transfusional iron load (assessed by liver iron concentration), but correlated significantly with serum bilirubin (R = 0 61, P &lt; 0 0001) and lactate dehydrogenase (R = 0 58, P &lt; 0 0001).	Bilirubin	148-157	ribonucleotide reductase regulatory subunit M2	Homo sapiens	0-4
22713574-2	2012	Among the members of the intracellular lipid binding protein family, L-FABP is of particular interest as it can i), bind two fatty acid molecules simultaneously and ii), accommodate a variety of bulkier physiological ligands such as bilirubin and fatty acyl CoA.	Bilirubin	233-242	fatty acid binding protein 1	Homo sapiens	69-75
22434241-10	2012	In vivo administration of CCl4 caused a significant increase of various biochemical parameters such as alanine amino transferase (ALT), aspartate amino transferase (AST), total bilirubin (TB) and a decrease in albumin (ALB) levels in serum or an increase in malondialdehyde (MDA) levels in the tissues when compared to a control.	Bilirubin	177-186	C-C motif chemokine ligand 4	Rattus norvegicus	26-30
22434241-10	2012	In vivo administration of CCl4 caused a significant increase of various biochemical parameters such as alanine amino transferase (ALT), aspartate amino transferase (AST), total bilirubin (TB) and a decrease in albumin (ALB) levels in serum or an increase in malondialdehyde (MDA) levels in the tissues when compared to a control.	Bilirubin	188-190	C-C motif chemokine ligand 4	Rattus norvegicus	26-30
22398043-3	2012	UDP-glucuronosyltransferase 1A1 (UGT1A1) is the only enzyme involved in the conjugation of bilirubin and the common UGT1A1*28 allele in the UGT1A1 gene, which is strongly associated with Gilbert"s syndrome in Caucasians, results in elevated plasma bilirubin levels.	Bilirubin	91-100	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-31
22213127-2	2012	In GS the UGT1A1*28 variant reduces bilirubin conjugation by 70% and is associated with irinotecan and protease inhibitor side effects.	Bilirubin	36-45	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	10-16
22398043-3	2012	UDP-glucuronosyltransferase 1A1 (UGT1A1) is the only enzyme involved in the conjugation of bilirubin and the common UGT1A1*28 allele in the UGT1A1 gene, which is strongly associated with Gilbert"s syndrome in Caucasians, results in elevated plasma bilirubin levels.	Bilirubin	91-100	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	33-39
22398043-3	2012	UDP-glucuronosyltransferase 1A1 (UGT1A1) is the only enzyme involved in the conjugation of bilirubin and the common UGT1A1*28 allele in the UGT1A1 gene, which is strongly associated with Gilbert"s syndrome in Caucasians, results in elevated plasma bilirubin levels.	Bilirubin	248-257	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-31
22398043-3	2012	UDP-glucuronosyltransferase 1A1 (UGT1A1) is the only enzyme involved in the conjugation of bilirubin and the common UGT1A1*28 allele in the UGT1A1 gene, which is strongly associated with Gilbert"s syndrome in Caucasians, results in elevated plasma bilirubin levels.	Bilirubin	248-257	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	33-39
22367021-12	2012	However, the predicted high activity UGT1A1 genotype, associated with low serum levels of the antioxidant bilirubin, was associated with an increased ESCC risk.	Bilirubin	106-115	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	37-43
22398043-3	2012	UDP-glucuronosyltransferase 1A1 (UGT1A1) is the only enzyme involved in the conjugation of bilirubin and the common UGT1A1*28 allele in the UGT1A1 gene, which is strongly associated with Gilbert"s syndrome in Caucasians, results in elevated plasma bilirubin levels.	Bilirubin	248-257	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	116-122
22398043-3	2012	UDP-glucuronosyltransferase 1A1 (UGT1A1) is the only enzyme involved in the conjugation of bilirubin and the common UGT1A1*28 allele in the UGT1A1 gene, which is strongly associated with Gilbert"s syndrome in Caucasians, results in elevated plasma bilirubin levels.	Bilirubin	248-257	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	116-122
22398043-10	2012	CONCLUSION: The homozygous state of the UGT1A1*28 polymorphism, associated with higher serum bilirubin levels, may be protective for the development of Crohn"s disease, suggesting that the anti-oxidant capacity of bilirubin may play a part.	Bilirubin	93-102	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	40-46
22398043-10	2012	CONCLUSION: The homozygous state of the UGT1A1*28 polymorphism, associated with higher serum bilirubin levels, may be protective for the development of Crohn"s disease, suggesting that the anti-oxidant capacity of bilirubin may play a part.	Bilirubin	214-223	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	40-46
22361233-0	2012	Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10.	Bilirubin	58-67	interleukin 10	Homo sapiens	172-186
22525203-1	2012	BACKGROUND: Liver growth factor (LGF) is an albumin-bilirubin complex with antioxidant actions in vitro.	Bilirubin	52-61	myotrophin	Rattus norvegicus	18-31
22419743-7	2012	The addition of the carbon monoxide donor carbon monoxide-releasing molecule-2 (CORM-2), in particular, and bilirubin (BR), two catalytic by-products of HY1, partially rescued the UV-C hypersensitivity, and other responses appeared in the hy1 mutant.	Bilirubin	108-117	RNA, Ro60-associated Y1	Homo sapiens	153-156
22664011-10	2012	CONCLUSION: Protein C activity recovered rapidly in patients with good allograft function but remained significantly lower in patients who had limited metabolic function as evidenced by increased total bilirubin levels.	Bilirubin	202-211	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	12-21
22337225-4	2012	After intraperitoneal sulphadimethoxine, bilirubin content peaked at fourfold in Cx and SC at 1 h; but at 11- to 13-fold in Cll and IC at 24 h; returning to control levels at 72 h. The Cyp mRNA peaked at 30-70 times control at 1 h in Cx and SC, but at 3-9 times control at 24 h in Cll and IC.	Bilirubin	41-50	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	185-188
21859771-4	2012	Animals treated with CCl4 exhibited significant elevation in AST, ALT, total bilirubin and caspase-3 and exhibited significant decrease in activities of SOD, CAT, GST and GSH contents.	Bilirubin	77-86	C-C motif chemokine ligand 4	Rattus norvegicus	21-25
21859771-5	2012	The combination (both capsaicin and CCl4) group has preserved the liver histology, liver enzymes and bilirubin close to normal, exhibited significant induction in the activities of CAT, SOD and GST, increased the liver content of GSH and active caspase-3 and conversely showed significant decrease in liver MDA content compared to CCl4 challenged rats.	Bilirubin	101-110	C-C motif chemokine ligand 4	Rattus norvegicus	36-40
22465937-0	2012	Metabolism of bilirubin by human cytochrome P450 2A6.	Bilirubin	14-23	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	33-52
22681659-12	2012	CONCLUSIONS: Gender and mean TBil bounce rate were independent risk factors in treatment of severe jaundice with HB-H-6 resin plasma perfusion.	Bilirubin	29-33	H6 family homeobox 1	Homo sapiens	116-119
22465937-13	2012	Furthermore, bilirubin treatment of HepG2 cells increased the CYP2A6 protein and activity levels with no effect on the corresponding mRNA.	Bilirubin	13-22	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	62-68
22465937-15	2012	Collectively, the observations indicate that the CYP2A6 may function as human "Bilirubin Oxidase" where bilirubin is potentially a substrate and a regulator of the enzyme.	Bilirubin	104-113	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	49-55
22262839-0	2012	Essential roles of Raf/extracellular signal-regulated kinase/mitogen-activated protein kinase pathway, YY1, and Ca2+ influx in growth arrest of human vascular smooth muscle cells by bilirubin.	Bilirubin	182-191	zinc fingers and homeoboxes 2	Homo sapiens	19-22
22262839-0	2012	Essential roles of Raf/extracellular signal-regulated kinase/mitogen-activated protein kinase pathway, YY1, and Ca2+ influx in growth arrest of human vascular smooth muscle cells by bilirubin.	Bilirubin	182-191	YY1 transcription factor	Homo sapiens	103-106
22262839-6	2012	We conclude that in the serum-stimulated human vascular smooth muscle primary cell cultures, bilirubin favors growth arrest, and we propose that this activity is regulated by its interaction with the Raf/ERK/MAPK pathway, effect on cyclin D1 and Raf content, altered retinoblastoma protein profile of hypophosphorylation, calcium influx, and YY1 proteolysis.	Bilirubin	93-102	zinc fingers and homeoboxes 2	Homo sapiens	200-203
22262839-6	2012	We conclude that in the serum-stimulated human vascular smooth muscle primary cell cultures, bilirubin favors growth arrest, and we propose that this activity is regulated by its interaction with the Raf/ERK/MAPK pathway, effect on cyclin D1 and Raf content, altered retinoblastoma protein profile of hypophosphorylation, calcium influx, and YY1 proteolysis.	Bilirubin	93-102	mitogen-activated protein kinase 1	Homo sapiens	204-207
22262839-6	2012	We conclude that in the serum-stimulated human vascular smooth muscle primary cell cultures, bilirubin favors growth arrest, and we propose that this activity is regulated by its interaction with the Raf/ERK/MAPK pathway, effect on cyclin D1 and Raf content, altered retinoblastoma protein profile of hypophosphorylation, calcium influx, and YY1 proteolysis.	Bilirubin	93-102	cyclin D1	Homo sapiens	232-241
22262839-6	2012	We conclude that in the serum-stimulated human vascular smooth muscle primary cell cultures, bilirubin favors growth arrest, and we propose that this activity is regulated by its interaction with the Raf/ERK/MAPK pathway, effect on cyclin D1 and Raf content, altered retinoblastoma protein profile of hypophosphorylation, calcium influx, and YY1 proteolysis.	Bilirubin	93-102	zinc fingers and homeoboxes 2	Homo sapiens	246-249
22262839-6	2012	We conclude that in the serum-stimulated human vascular smooth muscle primary cell cultures, bilirubin favors growth arrest, and we propose that this activity is regulated by its interaction with the Raf/ERK/MAPK pathway, effect on cyclin D1 and Raf content, altered retinoblastoma protein profile of hypophosphorylation, calcium influx, and YY1 proteolysis.	Bilirubin	93-102	YY1 transcription factor	Homo sapiens	342-345
22245901-1	2012	BACKGROUND &amp; AIMS: Multidrug resistance-associated protein 2 (in humans, MRP2; in rodents, Mrp2) mediates biliary excretion of bilirubin glucuronides.	Bilirubin	131-140	ATP binding cassette subfamily C member 2	Homo sapiens	23-64
22548790-12	2012	In addition, both Th17 frequency and plasm IL-17A levels positively correlated with ALT (r = 0.33,p = 0.01 Vs r = 0.29, p = 0.04) and total bilirubin levels (r = 0.72,p&lt;0.0001 Vs r = 0.53, p = 0.0001) in these chronic HBV-infected subjects.	Bilirubin	140-149	interleukin 17A	Homo sapiens	43-49
22262261-9	2012	Bilirubin was inversely correlated with high-sensitivity C-reactive protein (hsCRP) (r = -0.117, P &lt; 0.001).	Bilirubin	0-9	C-reactive protein	Homo sapiens	57-75
22430236-13	2012	Furthermore, Angiopoietin-2 levels were closely associated with Bilirubin-Lactate-Etiology score but not with other liver-specific markers.	Bilirubin	64-73	angiopoietin 2	Homo sapiens	13-27
22190497-3	2012	Elevated claudin-5 and cluster of differentiation 34 expression associated with increased blood vessel density suggests bilirubin-induced angiogenic sprouting.	Bilirubin	120-129	claudin 5	Homo sapiens	9-18
22190497-6	2012	These data add new insights into the pathophysiology of kernicterus, revealing vascular endothelial growth factor and its receptor 2, as well as angiogenic sprouting, as new players in neurologic damage by unconjugated bilirubin.	Bilirubin	219-228	vascular endothelial growth factor A	Homo sapiens	79-113
22245901-1	2012	BACKGROUND &amp; AIMS: Multidrug resistance-associated protein 2 (in humans, MRP2; in rodents, Mrp2) mediates biliary excretion of bilirubin glucuronides.	Bilirubin	131-140	ATP binding cassette subfamily C member 2	Homo sapiens	77-81
22245901-1	2012	BACKGROUND &amp; AIMS: Multidrug resistance-associated protein 2 (in humans, MRP2; in rodents, Mrp2) mediates biliary excretion of bilirubin glucuronides.	Bilirubin	131-140	ATP binding cassette subfamily C member 2	Homo sapiens	95-99
22147556-2	2012	The production of nitric oxide by the conversion of l-(2,3,4,5)-[3H] arginine to l-(3H) citrulline, the activity of haem oxygenase 1 (HO-1) through bilirubin synthesis and the expression of inducible nitric oxide synthase (iNOS), HO-1 proteins and messenger RNA by Western blot and reverse-transcribed polymerase chain reaction were also tested.	Bilirubin	148-157	heme oxygenase 1	Homo sapiens	116-132
22448797-2	2012	A polymorphism of the 5  end of the UGT1A1 gene promoter, a homozygous insertion of TA pairs (genotype UGT1A1*28/*28), results in a decrease in bilirubin glucuronidation activity and therefore leads to an increase in the level of unconjugated bilirubin (hyperbilirubinemia).	Bilirubin	144-153	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	36-42
22448797-2	2012	A polymorphism of the 5  end of the UGT1A1 gene promoter, a homozygous insertion of TA pairs (genotype UGT1A1*28/*28), results in a decrease in bilirubin glucuronidation activity and therefore leads to an increase in the level of unconjugated bilirubin (hyperbilirubinemia).	Bilirubin	144-153	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	103-109
22448797-2	2012	A polymorphism of the 5  end of the UGT1A1 gene promoter, a homozygous insertion of TA pairs (genotype UGT1A1*28/*28), results in a decrease in bilirubin glucuronidation activity and therefore leads to an increase in the level of unconjugated bilirubin (hyperbilirubinemia).	Bilirubin	243-252	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	36-42
22448797-2	2012	A polymorphism of the 5  end of the UGT1A1 gene promoter, a homozygous insertion of TA pairs (genotype UGT1A1*28/*28), results in a decrease in bilirubin glucuronidation activity and therefore leads to an increase in the level of unconjugated bilirubin (hyperbilirubinemia).	Bilirubin	243-252	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	103-109
22883035-10	2012	RESULTS: When the data were analyzed by multiple correlation, there were significant correlation between TB and cTnI, CK-MB, respectively (r = 0.212, -0.161, respectively, all P &lt; 0.05).	Bilirubin	105-107	troponin I3, cardiac type	Homo sapiens	112-116
22307138-2	2012	We hypothesized that sorafenib inhibits UGT1A1 and individuals carrying UGT1A1*28 and/or UGT1A9 variants experience greater sorafenib exposure and greater increase in sorafenib-induced plasma bilirubin concentration.	Bilirubin	192-201	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	72-78
22307138-2	2012	We hypothesized that sorafenib inhibits UGT1A1 and individuals carrying UGT1A1*28 and/or UGT1A9 variants experience greater sorafenib exposure and greater increase in sorafenib-induced plasma bilirubin concentration.	Bilirubin	192-201	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	89-95
22307138-3	2012	EXPERIMENTAL DESIGN: Inhibition of UGT1A1-mediated bilirubin glucuronidation by sorafenib was assessed in vitro.	Bilirubin	51-60	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	35-41
22307138-6	2012	RESULTS: Sorafenib exhibited mixed-mode inhibition of UGT1A1-mediated bilirubin glucuronidation (IC(50) = 18 mumol/L; K(i) = 11.7 mumol/L) in vitro.	Bilirubin	70-79	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	54-60
22307138-10	2012	UGT1A1*28 carriers showed two distinct phenotypes that could be explained by ABCC2-24C&gt;T genotype and are more likely to experience plasma bilirubin increases following sorafenib if they had high sorafenib exposure.	Bilirubin	142-151	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
21978438-9	2012	Endogenous biliary beta-glucuronidase hydrolysis of bilirubin conjugates in gallbladder bile provides HUCB(-) molecules that precipitate as insoluble salts with ionized Ca.	Bilirubin	52-61	glucuronidase beta	Homo sapiens	19-37
22147556-2	2012	The production of nitric oxide by the conversion of l-(2,3,4,5)-[3H] arginine to l-(3H) citrulline, the activity of haem oxygenase 1 (HO-1) through bilirubin synthesis and the expression of inducible nitric oxide synthase (iNOS), HO-1 proteins and messenger RNA by Western blot and reverse-transcribed polymerase chain reaction were also tested.	Bilirubin	148-157	heme oxygenase 1	Homo sapiens	134-138
22416852-7	2012	Study subjects were genotyped at the UGT1A1*28 locus, which is strongly associated with bilirubin levels.	Bilirubin	88-97	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	37-43
22085899-0	2012	UGT1A1 is a major locus influencing bilirubin levels in African Americans.	Bilirubin	36-45	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
22085899-10	2012	Also, we replicated the reported association between variants in SEMA3C and bilirubin levels.	Bilirubin	76-85	semaphorin 3C	Homo sapiens	65-71
22085899-11	2012	In summary, UGT1A1 is a major locus influencing bilirubin levels and the results of this study promise to contribute to understanding of the etiology and treatment of hyperbilirubinaemia in African-ancestry populations.	Bilirubin	48-57	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	12-18
22438843-10	2012	The BVR was reported to confer an antioxidant redox amplification cycle by which low, physiological bilirubin concentrations confer potent antioxidant protection via recycling of biliverdin from oxidized bilirubin by the BVR, linking this sink for oxidants to the NADPH pool.	Bilirubin	100-109	biliverdin reductase A	Homo sapiens	4-7
22438843-10	2012	The BVR was reported to confer an antioxidant redox amplification cycle by which low, physiological bilirubin concentrations confer potent antioxidant protection via recycling of biliverdin from oxidized bilirubin by the BVR, linking this sink for oxidants to the NADPH pool.	Bilirubin	100-109	biliverdin reductase A	Homo sapiens	221-224
22438843-10	2012	The BVR was reported to confer an antioxidant redox amplification cycle by which low, physiological bilirubin concentrations confer potent antioxidant protection via recycling of biliverdin from oxidized bilirubin by the BVR, linking this sink for oxidants to the NADPH pool.	Bilirubin	204-213	biliverdin reductase A	Homo sapiens	4-7
22438843-10	2012	The BVR was reported to confer an antioxidant redox amplification cycle by which low, physiological bilirubin concentrations confer potent antioxidant protection via recycling of biliverdin from oxidized bilirubin by the BVR, linking this sink for oxidants to the NADPH pool.	Bilirubin	204-213	biliverdin reductase A	Homo sapiens	221-224
22438844-2	2012	Conversion of BV to bilirubin (BR) is catalyzed by biliverdin reductase (BVR) and is required for the downstream signaling and nuclear localization of BVR.	Bilirubin	20-29	biliverdin reductase A	Homo sapiens	51-71
22438844-2	2012	Conversion of BV to bilirubin (BR) is catalyzed by biliverdin reductase (BVR) and is required for the downstream signaling and nuclear localization of BVR.	Bilirubin	20-29	biliverdin reductase A	Homo sapiens	73-76
22438844-2	2012	Conversion of BV to bilirubin (BR) is catalyzed by biliverdin reductase (BVR) and is required for the downstream signaling and nuclear localization of BVR.	Bilirubin	20-29	biliverdin reductase A	Homo sapiens	151-154
22438844-2	2012	Conversion of BV to bilirubin (BR) is catalyzed by biliverdin reductase (BVR) and is required for the downstream signaling and nuclear localization of BVR.	Bilirubin	31-33	biliverdin reductase A	Homo sapiens	51-71
22438844-2	2012	Conversion of BV to bilirubin (BR) is catalyzed by biliverdin reductase (BVR) and is required for the downstream signaling and nuclear localization of BVR.	Bilirubin	31-33	biliverdin reductase A	Homo sapiens	73-76
22438844-2	2012	Conversion of BV to bilirubin (BR) is catalyzed by biliverdin reductase (BVR) and is required for the downstream signaling and nuclear localization of BVR.	Bilirubin	31-33	biliverdin reductase A	Homo sapiens	151-154
21900842-8	2012	Subgroup analyses showed that there was a significant increase in bilirubin levels in participants in the 12-KKW group (0.076 mg dL-1) who were classified as insulin resistant (homeostatic model assessment for insulin resistance score &gt; 2.6) compared with insulin-resistant control participants (0.018 mg dL-1, P = 0.028).	Bilirubin	66-75	insulin	Homo sapiens	158-165
21900842-8	2012	Subgroup analyses showed that there was a significant increase in bilirubin levels in participants in the 12-KKW group (0.076 mg dL-1) who were classified as insulin resistant (homeostatic model assessment for insulin resistance score &gt; 2.6) compared with insulin-resistant control participants (0.018 mg dL-1, P = 0.028).	Bilirubin	66-75	insulin	Homo sapiens	210-217
21900842-8	2012	Subgroup analyses showed that there was a significant increase in bilirubin levels in participants in the 12-KKW group (0.076 mg dL-1) who were classified as insulin resistant (homeostatic model assessment for insulin resistance score &gt; 2.6) compared with insulin-resistant control participants (0.018 mg dL-1, P = 0.028).	Bilirubin	66-75	insulin	Homo sapiens	210-217
22470341-6	2012	Bilirubin-mediated inhibition of neointimal thickening was associated with a significant decrease in ERK activity and cyclin D1 and A protein expression, and an increase in p21 and p53 protein expression in injured blood vessels.	Bilirubin	0-9	mitogen-activated protein kinase 1	Homo sapiens	101-104
22470341-6	2012	Bilirubin-mediated inhibition of neointimal thickening was associated with a significant decrease in ERK activity and cyclin D1 and A protein expression, and an increase in p21 and p53 protein expression in injured blood vessels.	Bilirubin	0-9	cyclin D1	Homo sapiens	118-127
22470341-6	2012	Bilirubin-mediated inhibition of neointimal thickening was associated with a significant decrease in ERK activity and cyclin D1 and A protein expression, and an increase in p21 and p53 protein expression in injured blood vessels.	Bilirubin	0-9	H3 histone pseudogene 16	Homo sapiens	173-176
22470341-6	2012	Bilirubin-mediated inhibition of neointimal thickening was associated with a significant decrease in ERK activity and cyclin D1 and A protein expression, and an increase in p21 and p53 protein expression in injured blood vessels.	Bilirubin	0-9	tumor protein p53	Homo sapiens	181-184
22408623-1	2012	Bilirubin-IX-alpha (BR) is the final product of heme metabolism through the heme oxygenase/biliverdin reductase (HO/BVR) system.	Bilirubin	0-9	biliverdin reductase A	Homo sapiens	113-119
22408623-6	2012	Furthermore, BR retained its antiviral activity even complexed with a saturating concentration of human serum-albumin.	Bilirubin	13-15	albumin	Homo sapiens	104-117
21895718-6	2012	CYP2E1*c2 polymorphic allele and c1/c2 genotype frequency were significantly higher (p &lt; 0.05 and p &lt; 0.01, respectively) in patients with AC when compared to C. Patients with AC, carrying the CYP2E1*c2 allele, exhibited more decompensated liver functioning evaluated by total bilirubin and prothrombin time, than c1 allele carrying patients (p &lt; 0.05).	Bilirubin	283-292	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6
22457648-6	2012	In this regard, the biliverdin to bilirubin conversion pathway, via biliverdin reductase (BVR), is suggested to be another major protective mechanism that scavenges lipophilic oxidants because of the lipophilic nature of bilirubin.	Bilirubin	34-43	biliverdin reductase A	Homo sapiens	68-88
22457648-6	2012	In this regard, the biliverdin to bilirubin conversion pathway, via biliverdin reductase (BVR), is suggested to be another major protective mechanism that scavenges lipophilic oxidants because of the lipophilic nature of bilirubin.	Bilirubin	34-43	biliverdin reductase A	Homo sapiens	90-93
22457648-6	2012	In this regard, the biliverdin to bilirubin conversion pathway, via biliverdin reductase (BVR), is suggested to be another major protective mechanism that scavenges lipophilic oxidants because of the lipophilic nature of bilirubin.	Bilirubin	221-230	biliverdin reductase A	Homo sapiens	68-88
22457648-6	2012	In this regard, the biliverdin to bilirubin conversion pathway, via biliverdin reductase (BVR), is suggested to be another major protective mechanism that scavenges lipophilic oxidants because of the lipophilic nature of bilirubin.	Bilirubin	221-230	biliverdin reductase A	Homo sapiens	90-93
22457648-7	2012	The efficiency of this bilirubin system might be potentiated by operation of the intertwined bicyclic systems of the suggested redox metabolic cycle of biliverdin and bilirubin and the interactive control cycle of BVR and heme oxygenase.	Bilirubin	23-32	biliverdin reductase A	Homo sapiens	214-217
22338062-6	2012	There were no significant effects on Klotho levels with the addition of common interferents such as ascorbate, triglycerides, or hemolysis; only bilirubin (250 mg/L) significantly reduced Klotho levels (P &lt; .05).	Bilirubin	145-154	klotho	Homo sapiens	188-194
22347861-3	2012	Protection from cardiovascular disease is also observed in patients with Gilbert"s syndrome which is a disease characterized by mutations in hepatic UGT1A1, the enzyme responsible for the conjugation of bilirubin into the bile.	Bilirubin	203-212	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	149-155
22353523-9	2012	ATIII is correlated with 13 of 14 other clinical tests, including albumin, bilirubin, prothrombin time, rapid turnover proteins, HGF, ICGR15 and others.	Bilirubin	75-84	serpin family C member 1	Homo sapiens	0-5
22200625-5	2012	Heme oxygenase-1 (HO-1) is the inducible isoform of the first and rate-limiting enzyme which degrades heme into carbon monoxide, ferritin and bilirubin.	Bilirubin	142-151	heme oxygenase 1	Homo sapiens	0-16
22200625-5	2012	Heme oxygenase-1 (HO-1) is the inducible isoform of the first and rate-limiting enzyme which degrades heme into carbon monoxide, ferritin and bilirubin.	Bilirubin	142-151	heme oxygenase 1	Homo sapiens	18-22
22040928-7	2012	A regression model showed that changes in PDR(ICG) were associated with age, TBSA%, plasma bilirubin concentration, plasma C-reactive protein concentration, and cardiac index.	Bilirubin	91-100	PDR	Homo sapiens	42-50
22185821-4	2012	The protection required functional heme oxygenase-1 activity, since zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, prevented NF-kappaB inhibition, and the presence of exogenous carbon monoxide and bilirubin afforded cytoprotection against paraquat-induced toxicity by preventing NF-kappaB activation.	Bilirubin	204-213	heme oxygenase 1	Rattus norvegicus	35-51
22232210-0	2012	Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.	Bilirubin	95-104	solute carrier organic anion transporter family member 1B1	Homo sapiens	9-16
21760472-0	2012	Bilirubin dependence on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass index.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	24-30
21760472-2	2012	This study evaluates how several nongenetic causes and the genetic UGT1A1 polymorphisms contribute for bilirubin levels, in a cohort of 146 young Caucasian females.	Bilirubin	103-112	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	67-73
22074793-3	2012	The obtained bilirubin biosensor presents high-selectivity monitoring of bilirubin, better reproducibility, shorter response time (30 min), wider linear range (0.1-50 muM), and lower detection limit (0.05 muM).	Bilirubin	13-22	latexin	Homo sapiens	167-170
22074793-3	2012	The obtained bilirubin biosensor presents high-selectivity monitoring of bilirubin, better reproducibility, shorter response time (30 min), wider linear range (0.1-50 muM), and lower detection limit (0.05 muM).	Bilirubin	13-22	latexin	Homo sapiens	205-208
22232210-0	2012	Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.	Bilirubin	95-104	solute carrier organic anion transporter family member 1B3	Homo sapiens	21-28
22232210-7	2012	Using mice deficient in Oatp1a/1b and in the multispecific sinusoidal export pump Abcc3, we found that Abcc3 secretes bilirubin conjugates into the blood, while Oatp1a/1b transporters mediate their hepatic reuptake.	Bilirubin	118-127	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	82-87
22232210-7	2012	Using mice deficient in Oatp1a/1b and in the multispecific sinusoidal export pump Abcc3, we found that Abcc3 secretes bilirubin conjugates into the blood, while Oatp1a/1b transporters mediate their hepatic reuptake.	Bilirubin	118-127	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	103-108
22232210-10	2012	Thus, disruption of hepatic reuptake of bilirubin glucuronide due to coexisting OATP1B1 and OATP1B3 deficiencies explains Rotor-type hyperbilirubinemia.	Bilirubin	40-49	solute carrier organic anion transporter family member 1B1	Homo sapiens	80-87
22232210-10	2012	Thus, disruption of hepatic reuptake of bilirubin glucuronide due to coexisting OATP1B1 and OATP1B3 deficiencies explains Rotor-type hyperbilirubinemia.	Bilirubin	40-49	solute carrier organic anion transporter family member 1B3	Homo sapiens	92-99
21447442-9	2012	Similar to EGCG treatment, silencing of caveolin-1 by siRNA technique also resulted in up-regulation of Nrf2, HO-1 and bilirubin production.	Bilirubin	119-128	caveolin 1	Homo sapiens	40-50
25083222-5	2012	In two classes (COMT inhibitors and endothelin receptor antagonists), drugs with regulatory action had significantly higher rates of ALT elevation of more than threefold and greater numbers of patients with combined elevation of ALT and bilirubin than drugs without regulatory action.	Bilirubin	237-246	catechol-O-methyltransferase	Homo sapiens	16-20
22095827-2	2012	Niacin is a pleiotropic drug that slows the progression of coronary artery disease and increases serum levels of the HO-1 enzymatic product bilirubin.	Bilirubin	140-149	heme oxygenase 1	Homo sapiens	117-121
22195275-0	2012	Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin.	Bilirubin	129-138	heme oxygenase 1	Homo sapiens	0-16
22138245-10	2012	Taken together with the biochemical function of HO-1 that catalyzes heme into CO and bilirubin, HO-1 expression may improve the circulation and compensate with oxidative tissue damages induced by hypoxia.	Bilirubin	85-94	heme oxygenase 1	Homo sapiens	48-52
22138245-10	2012	Taken together with the biochemical function of HO-1 that catalyzes heme into CO and bilirubin, HO-1 expression may improve the circulation and compensate with oxidative tissue damages induced by hypoxia.	Bilirubin	85-94	heme oxygenase 1	Homo sapiens	96-100
23631285-5	2012	The patients carrying the mutation of the gene encoding UGT1A enzyme lack the ability of bilirubin glucuronidation, and suffer from the inherited un-conjugated hyperbilirubinemia (Gilbert syndrome, Crigler-Najjar type 1 and 2 syndrome).	Bilirubin	89-98	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	56-61
22118420-0	2012	A genome-wide search for non-UGT1A1 markers associated with unconjugated bilirubin level reveals significant association with a polymorphic marker near a gene of the nucleoporin family.	Bilirubin	73-82	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	29-35
22118420-1	2012	Variants in the UGT1A1 gene and its promoter are known to determine levels of unconjugated bilirubin (UCB), but do not explain all cases of unconjugated hyperbilirubinemia.	Bilirubin	91-100	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	16-22
22118420-8	2012	NUP153, whose product is a major regulatory factor in bidirectional transport of biomolecules across nucleus to cytosol, is associated with the transport of biliverdin reductase, which is important for bilirubin conjugation.	Bilirubin	202-211	nucleoporin 153	Homo sapiens	0-6
21845530-5	2012	Furthermore, in a rat model of LTA-induced sepsis, we demonstrated that prophylactic administration of exogenous human Hsp70 significantly exacerbated numerous homeostatic and hemodynamic disturbances induced by LTA challenge and partially normalized the coagulation system and multiple biochemical blood parameters, including albumin and bilirubin concentrations, which were severely disturbed after LTA injections.	Bilirubin	339-348	heat shock protein family A (Hsp70) member 4	Homo sapiens	119-124
23885401-2	2012	The cholestatic effect of cytokines (e.g. IL-1beta, IL-6) is believed to result from the repression of genes that normally mediated the hepatic uptake, metabolism, and biliary excretion of bile salts and bilirubin.	Bilirubin	204-213	interleukin 1 beta	Homo sapiens	42-50
23885401-2	2012	The cholestatic effect of cytokines (e.g. IL-1beta, IL-6) is believed to result from the repression of genes that normally mediated the hepatic uptake, metabolism, and biliary excretion of bile salts and bilirubin.	Bilirubin	204-213	interleukin 6	Homo sapiens	52-56
23885401-9	2012	A significant positive correlation was found between of IL-1beta in breast milk and total serum bilirubin levels (r = 0.494, P &lt; 0.001).	Bilirubin	96-105	interleukin 1 beta	Homo sapiens	56-64
21983082-3	2012	Clearance of bilirubin requires the expression of uridine diphosphate glucuronosyltransferase (UGT) 1A1; we investigated its role in the association between breast feeding with jaundice in mice.	Bilirubin	13-22	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	50-103
21983082-8	2012	Formula-fed hUGT1 mice had lower serum levels of bilirubin, which resulted from induction of UGT1A1 in the gastrointestinal tract.	Bilirubin	49-58	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	12-17
21983082-8	2012	Formula-fed hUGT1 mice had lower serum levels of bilirubin, which resulted from induction of UGT1A1 in the gastrointestinal tract.	Bilirubin	49-58	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	93-99
21997310-3	2012	Polymorphisms of the GSTM1 and GSTT1 genes may affect ligandin functions that are important in bilirubin transportation.	Bilirubin	95-104	glutathione S-transferase mu 1	Homo sapiens	21-26
21997310-3	2012	Polymorphisms of the GSTM1 and GSTT1 genes may affect ligandin functions that are important in bilirubin transportation.	Bilirubin	95-104	glutathione S-transferase theta 1	Homo sapiens	31-36
21997310-7	2012	RESULTS: GSTM1 null genotype was significantly higher in the patient compared with control groups (P = 0.005; odds ratio = 2.43; 95% confidence interval, 1.29-4.55) and was significantly associated with higher bilirubin levels compared with the wild genotype (P &lt; 0.001).	Bilirubin	210-219	glutathione S-transferase mu 1	Homo sapiens	9-14
21997310-10	2012	CONCLUSIONS: Neonates with the GSTM1 null genotype are at high risk to develop pathologic hyperbilirubinemia and may have higher bilirubin levels.	Bilirubin	95-104	glutathione S-transferase mu 1	Homo sapiens	31-36
22098322-6	2012	RESULTS: Patients with low post-operative bilirubin had lower levels of NTCP, MDR3 and BSEP mRNA compared to those with high bilirubin after Pringle manoeuvre.	Bilirubin	42-51	solute carrier family 10 member 1	Homo sapiens	72-76
23430851-2	2012	It is caused by deficiency of the liver enzyme responsible for bilirubin elimination, the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1; EC 2.4.1.17).	Bilirubin	63-72	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	90-137
23430851-2	2012	It is caused by deficiency of the liver enzyme responsible for bilirubin elimination, the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1; EC 2.4.1.17).	Bilirubin	63-72	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	139-145
23964438-4	2012	It was demonstrated that the genetic variations cause a decrease in UGT1A1 activity in neonates, leading to an accumulation of unconjugated bilirubin in serum.	Bilirubin	140-149	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	68-74
22098322-6	2012	RESULTS: Patients with low post-operative bilirubin had lower levels of NTCP, MDR3 and BSEP mRNA compared to those with high bilirubin after Pringle manoeuvre.	Bilirubin	42-51	ATP binding cassette subfamily B member 4	Homo sapiens	78-82
22098322-6	2012	RESULTS: Patients with low post-operative bilirubin had lower levels of NTCP, MDR3 and BSEP mRNA compared to those with high bilirubin after Pringle manoeuvre.	Bilirubin	42-51	ATP binding cassette subfamily B member 11	Homo sapiens	87-91
22098322-8	2012	Baseline median mRNA expression of all four transporters prior to Pringle manoeuvre tended to be lower in the low bilirubin group whereas expression of HSP70 was higher in the low bilirubin group compared to the high bilirubin group.	Bilirubin	180-189	heat shock protein family A (Hsp70) member 4	Homo sapiens	152-157
22098322-8	2012	Baseline median mRNA expression of all four transporters prior to Pringle manoeuvre tended to be lower in the low bilirubin group whereas expression of HSP70 was higher in the low bilirubin group compared to the high bilirubin group.	Bilirubin	180-189	heat shock protein family A (Hsp70) member 4	Homo sapiens	152-157
22098322-9	2012	DISCUSSION: Higher mRNA levels of HSP70 in the low bilirubin group could indicate a possible protective effect of high HSP70 levels against IR injury.	Bilirubin	51-60	heat shock protein family A (Hsp70) member 4	Homo sapiens	34-39
22098322-9	2012	DISCUSSION: Higher mRNA levels of HSP70 in the low bilirubin group could indicate a possible protective effect of high HSP70 levels against IR injury.	Bilirubin	51-60	heat shock protein family A (Hsp70) member 4	Homo sapiens	119-124
22188103-8	2012	In addition, a negative correlation was found between CIMT and serum albumin and bilirubin in the ESRD group, and this correlation was independent of age and body mass index.	Bilirubin	81-90	CIMT	Homo sapiens	54-58
22854341-6	2012	RESULTS: The combined odds ratio from a simple summary-level fixed-effects meta-analysis of treatment-emergent abnormalities in serum alanine aminotransferase (ALT) (defined as greater than the upper level of normal for 2 successive measurements) was 1.09 (95% CI 0.93-1.28), and in total bilirubin 1.24 (95% CI 1.03-1.49).	Bilirubin	289-298	glutamic--pyruvic transaminase	Homo sapiens	134-158
23006937-7	2012	Subclassification of tercile I patients by AFP showed that patients with high serum AFP had increased numbers of tumor nodules, more PV thrombosis, higher bilirubin, ALKP, and GGTP levels, and shorter survival.	Bilirubin	155-164	alpha fetoprotein	Homo sapiens	84-87
22907525-9	2012	CRP was highly correlated with direct bilirubin.	Bilirubin	38-47	C-reactive protein	Homo sapiens	0-3
23230722-12	2012	CONCLUSION: In Polish adults serum total bilirubin level is inversely related to the prevalence of MS and insulin resistance.	Bilirubin	41-50	insulin	Homo sapiens	106-113
22496754-8	2012	Down-regulation of miR-26a by anti-miR-26a expression led to enhanced proliferation of hepatocytes, and both LBWR and hepatocyte proliferation (Ki-67(+) cells %) showed an increased tendency, while liver damage, indicated by aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin (T-Bil), was reduced.	Bilirubin	300-309	microRNA 26a-1	Mus musculus	19-26
23230722-0	2012	Inverse association of serum bilirubin with metabolic syndrome and insulin resistance in Polish population.	Bilirubin	29-38	insulin	Homo sapiens	67-74
23240054-6	2012	VDR-null mice had elevated plasma conjugated bilirubin levels three days after BDL compared with wild-type mice.	Bilirubin	45-54	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	0-3
23240054-7	2012	Urine bilirubin levels and renal mRNA and/or protein expression of multidrug resistance-associated proteins 2 and 4 were decreased in VDR-null mice, suggesting impaired excretion of conjugated bilirubin into urine.	Bilirubin	6-15	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	134-137
23240054-7	2012	Urine bilirubin levels and renal mRNA and/or protein expression of multidrug resistance-associated proteins 2 and 4 were decreased in VDR-null mice, suggesting impaired excretion of conjugated bilirubin into urine.	Bilirubin	193-202	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	134-137
23240054-11	2012	These results reveal a role of VDR in bilirubin clearance during cholestasis.	Bilirubin	38-47	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	31-34
22761690-8	2012	Further experiments demonstrated that carbon monoxide and bilirubin, the byproducts derived from heme degradation by HO-1, enhanced macrophage migration by increasing phosphorylation of p38 and FAK, respectively.	Bilirubin	58-67	heme oxygenase 1	Mus musculus	117-121
22761690-8	2012	Further experiments demonstrated that carbon monoxide and bilirubin, the byproducts derived from heme degradation by HO-1, enhanced macrophage migration by increasing phosphorylation of p38 and FAK, respectively.	Bilirubin	58-67	mitogen-activated protein kinase 14	Mus musculus	186-189
22761690-8	2012	Further experiments demonstrated that carbon monoxide and bilirubin, the byproducts derived from heme degradation by HO-1, enhanced macrophage migration by increasing phosphorylation of p38 and FAK, respectively.	Bilirubin	58-67	PTK2 protein tyrosine kinase 2	Mus musculus	194-197
22558097-1	2012	Serum bilirubin levels have been associated with polymorphisms in the UGT1A1 promoter in normal populations and in patients with hemolytic anemias, including sickle cell anemia.	Bilirubin	6-15	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	70-76
22558097-8	2012	These results confirm that the UGT1A region is the major regulator of bilirubin metabolism in African Americans with sickle cell anemia, similar to what is observed in other ethnicities.	Bilirubin	70-79	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	31-36
23230722-4	2012	The aim of this study was to evaluate the association of total serum bilirubin level with MS and insulin resistance in Poland.	Bilirubin	69-78	insulin	Homo sapiens	97-104
23230722-10	2012	In study group there was also a strong, independent association of bilirubin level with fasting insulin level and insulin resistance (HOMA-IR).	Bilirubin	67-76	insulin	Homo sapiens	96-103
23230722-10	2012	In study group there was also a strong, independent association of bilirubin level with fasting insulin level and insulin resistance (HOMA-IR).	Bilirubin	67-76	insulin	Homo sapiens	114-121
21837749-7	2011	Furthermore, bilirubin down-regulated RUNX2 (runt-related transcription factor 2) gene expression, a basic osteogenic factor involved in osteoblast differentiation, and serum from jaundiced patients significantly up-regulated the RANKL/OPG (receptor activator of nuclear factor-kappaB ligand/osteoprotegerin) gene expression ratio, a system closely involved in osteoblast-induced osteoclastogenesis.	Bilirubin	13-22	RUNX family transcription factor 2	Homo sapiens	38-43
23230722-11	2012	The odds ratio of insulin resistance was 0.53 (0.38-0.74) for the fourth quartile in reference to the lowest quartile of bilirubin.	Bilirubin	121-130	insulin	Homo sapiens	18-25
21840000-2	2011	As statins can stimulate heme oxygenase-1 (HO-1), which increases bilirubin production, we investigated whether statins in routine use increase total bilirubin levels in subjects at high cardiovascular risk.	Bilirubin	66-75	heme oxygenase 1	Homo sapiens	25-41
21880828-6	2011	Expression levels of both proteins in liver were highly variable (28- and 20-fold, respectively) and correlated strongly with UGT enzyme activity toward the probe substrates bilirubin and 1-naphthol, respectively.	Bilirubin	174-183	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	126-129
21837749-7	2011	Furthermore, bilirubin down-regulated RUNX2 (runt-related transcription factor 2) gene expression, a basic osteogenic factor involved in osteoblast differentiation, and serum from jaundiced patients significantly up-regulated the RANKL/OPG (receptor activator of nuclear factor-kappaB ligand/osteoprotegerin) gene expression ratio, a system closely involved in osteoblast-induced osteoclastogenesis.	Bilirubin	13-22	RUNX family transcription factor 2	Homo sapiens	45-80
21837749-7	2011	Furthermore, bilirubin down-regulated RUNX2 (runt-related transcription factor 2) gene expression, a basic osteogenic factor involved in osteoblast differentiation, and serum from jaundiced patients significantly up-regulated the RANKL/OPG (receptor activator of nuclear factor-kappaB ligand/osteoprotegerin) gene expression ratio, a system closely involved in osteoblast-induced osteoclastogenesis.	Bilirubin	13-22	TNF superfamily member 11	Homo sapiens	230-235
21837749-7	2011	Furthermore, bilirubin down-regulated RUNX2 (runt-related transcription factor 2) gene expression, a basic osteogenic factor involved in osteoblast differentiation, and serum from jaundiced patients significantly up-regulated the RANKL/OPG (receptor activator of nuclear factor-kappaB ligand/osteoprotegerin) gene expression ratio, a system closely involved in osteoblast-induced osteoclastogenesis.	Bilirubin	13-22	basic transcription factor 3 pseudogene 11	Homo sapiens	236-239
21843953-3	2011	Administration of recombinant human IL-22 (rhIL-22) reduced the death rate markedly and prevented mice from severe hepatic injury, as evidenced by decreased serum alanine aminotransferase (ALT) and total bilirubin (T.Bil) activity as well as improved histological signs in liver.	Bilirubin	204-213	interleukin 22	Homo sapiens	36-41
25755387-1	2011	Crigler-Najjar syndrome (CN) is a congenital defect in bilirubin conjugation due to complete or partial deficiency of uridine 5"-diphosphate-glucuronosyltransferase (UGT).	Bilirubin	55-64	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	118-164
25755387-1	2011	Crigler-Najjar syndrome (CN) is a congenital defect in bilirubin conjugation due to complete or partial deficiency of uridine 5"-diphosphate-glucuronosyltransferase (UGT).	Bilirubin	55-64	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	166-169
21871474-1	2011	We have previously shown that bilirubin (BR), a breakdown product of haem, is a strong inhibitor and a high affinity substrate of the mouse cytochrome P450 2A5 (CYP2A5).	Bilirubin	30-39	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	140-159
21871474-1	2011	We have previously shown that bilirubin (BR), a breakdown product of haem, is a strong inhibitor and a high affinity substrate of the mouse cytochrome P450 2A5 (CYP2A5).	Bilirubin	30-39	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	161-167
21871474-9	2011	Bilirubin treatment of primary hepatocytes increased the CYP2A5 protein and activity levels with no effect on the corresponding mRNA.	Bilirubin	0-9	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	57-63
21871474-11	2011	Collectively, the observations suggest that the CYP2A5 is potentially an inducible "BR oxidase" where BR may accelerate its own metabolism through stabilization of the CYP2A5 protein.	Bilirubin	84-86	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	48-54
21871474-11	2011	Collectively, the observations suggest that the CYP2A5 is potentially an inducible "BR oxidase" where BR may accelerate its own metabolism through stabilization of the CYP2A5 protein.	Bilirubin	84-86	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	168-174
21801714-0	2011	Carlinoside reduces hepatic bilirubin accumulation by stimulating bilirubin-UGT activity through Nrf2 gene expression.	Bilirubin	66-75	NFE2 like bZIP transcription factor 2	Homo sapiens	97-101
21801714-2	2011	Free bilirubin is insoluble; its glucuronidation by bilirubin-UGT enzyme (UGT1A1) makes it soluble and eliminates it through urine and faeces.	Bilirubin	5-14	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	74-80
21801714-2	2011	Free bilirubin is insoluble; its glucuronidation by bilirubin-UGT enzyme (UGT1A1) makes it soluble and eliminates it through urine and faeces.	Bilirubin	52-61	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	74-80
21801714-3	2011	Taking CCl(4) induced rat liver dysfunction model, we demonstrated that suppression of UGT1A1 activity in rat liver increased serum bilirubin level which could be reversed by carlinoside (Cln), a flavone glycoside.	Bilirubin	132-141	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	87-93
21726166-0	2011	Relationship between bilirubin and C-reactive protein.	Bilirubin	21-30	C-reactive protein	Homo sapiens	35-53
21726166-2	2011	However, the number of studies which have focused on the relationship between bilirubin and C-reactive protein (CRP), which is a marker reflecting chronic vascular inflammation, are limited.	Bilirubin	78-87	C-reactive protein	Homo sapiens	92-110
21726166-2	2011	However, the number of studies which have focused on the relationship between bilirubin and C-reactive protein (CRP), which is a marker reflecting chronic vascular inflammation, are limited.	Bilirubin	78-87	C-reactive protein	Homo sapiens	112-115
21726166-4	2011	RESULT: CRP level showed a declining tendency as total bilirubin increased according to total bilirubin quartiles.	Bilirubin	55-64	C-reactive protein	Homo sapiens	8-11
21726166-4	2011	RESULT: CRP level showed a declining tendency as total bilirubin increased according to total bilirubin quartiles.	Bilirubin	94-103	C-reactive protein	Homo sapiens	8-11
21726166-5	2011	Negative relations of CRP with both total and direct bilirubin were found after adjustment of age, body mass index, hypertension, diabetes, hypercholesterolemia, cardiovascular disease, taking aspirin, smoking, alcohol drinking and regular exercise and total bilirubin or direct bilirubin.	Bilirubin	53-62	C-reactive protein	Homo sapiens	22-25
21726166-5	2011	Negative relations of CRP with both total and direct bilirubin were found after adjustment of age, body mass index, hypertension, diabetes, hypercholesterolemia, cardiovascular disease, taking aspirin, smoking, alcohol drinking and regular exercise and total bilirubin or direct bilirubin.	Bilirubin	259-268	C-reactive protein	Homo sapiens	22-25
21726166-5	2011	Negative relations of CRP with both total and direct bilirubin were found after adjustment of age, body mass index, hypertension, diabetes, hypercholesterolemia, cardiovascular disease, taking aspirin, smoking, alcohol drinking and regular exercise and total bilirubin or direct bilirubin.	Bilirubin	259-268	C-reactive protein	Homo sapiens	22-25
21726166-6	2011	CONCLUSIONS: This study found that elevation of the two types of bilirubin (total and direct) have a relationship with a low serum CRP level among apparently healthy Korean adults.	Bilirubin	65-74	C-reactive protein	Homo sapiens	131-134
21726166-7	2011	It is hypothesized that a low serum CRP level may be due to the antioxidant and anti-inflammatory effects of bilirubin metabolism.	Bilirubin	109-118	C-reactive protein	Homo sapiens	36-39
21917385-4	2011	These considerations suggest that bilirubin, generated within lymphocytes by HO-1 activation, may play a physiological role in the promotion of Treg immunomodulation.	Bilirubin	34-43	heme oxygenase 1	Homo sapiens	77-81
21917385-5	2011	This effect of bilirubin is likely to be independent of NADPH oxidase inhibition, since the NAPDH oxidase activity of macrophages is necessary for Treg induction, possibly because it contributes to HO-1 induction in lymphocytes.	Bilirubin	15-24	heme oxygenase 1	Homo sapiens	198-202
22010794-6	2011	ALP levels rose significantly with rising total bilirubin level.	Bilirubin	48-57	alkaline phosphatase, placental	Homo sapiens	0-3
21552291-11	2011	Finally, H(2)O(2)-mediated cell death was rescued significantly in p53-deficient cells by antioxidant treatment, as well as by bilirubin, a by-product of HO-1 metabolism.	Bilirubin	127-136	heme oxygenase 1	Homo sapiens	154-158
21649640-3	2011	In mice, this herb and its principal ingredient scoparone were found to accelerate the clearance of bilirubin accompanied by the induction of uridine diphosphate-5"-glucuronosyltransferase-1A1 (UGT1A1), a bilirubin processing enzyme.	Bilirubin	205-214	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	142-192
21796020-8	2011	In contrast, in the presence of 100 muM pregnanediol, bilirubin glucuronidation of G71R-UGT1A1 was reduced to 51% of WT.	Bilirubin	54-63	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	88-94
21741353-4	2011	All CYPOR variants exhibited decreased bilirubin production relative to WT, with a lower apparent affinity of the CYPOR-HO-1 complex than WT.	Bilirubin	39-48	cytochrome p450 oxidoreductase	Homo sapiens	4-9
21970875-7	2011	In addition, raised LRG1 and CA19-9 were found to be independent predictors of BTC in the presence of elevated bilirubin, C-reactive protein and alkaline phosphatase.	Bilirubin	111-120	leucine rich alpha-2-glycoprotein 1	Homo sapiens	20-24
22090784-1	2011	Heme oxygenase-1 (HO-1) system catalyzes heme to biologically active products: carbon monoxide, biliverdin/bilirubin and free iron.	Bilirubin	107-116	heme oxygenase 1	Homo sapiens	0-16
21465143-8	2011	There was an especially important relationship between serum bilirubin and AFP, suggesting that HCC growth and liver factors were interdependent.	Bilirubin	61-70	alpha fetoprotein	Homo sapiens	75-78
21592495-3	2011	Hyperbilirubinemia was diagnosed when a full term neonate had a bilirubin level  15.0 mg/dL (256.5 muM) in serum at 3 days old.	Bilirubin	5-14	latexin	Homo sapiens	99-102
21091076-3	2011	By degrading the oxidant heme and generating the antioxidant bilirubin and anti-inflammatory molecule carbon monoxide, HO-1 may protect cell from injury due to oxidative and pathological stress.	Bilirubin	61-70	heme oxygenase 1	Homo sapiens	119-123
22098234-4	2011	Second, recently many researchers are focused on CAR because the significance is increasingly shown of its influence on a variety of physiological functions, such as gluconeogenesis, metabolism of xenobiotics, fatty acids, bilirubin, and bile acids, hormonal regulation, etc.	Bilirubin	223-232	nuclear receptor subfamily 1 group I member 3	Homo sapiens	49-52
22338227-8	2011	In addition, the serum level of TNF-alpha was found to be positively correlated with serum total bilirubin (r = 0.891, P &lt; 0.01) and MELD score (r = 0.792, P &lt; 0.01), but to be negatively correlated with prothrombin activity (r = - 0.511, P &lt; 0.05) in patients with ACHBLF.	Bilirubin	97-106	tumor necrosis factor	Homo sapiens	32-41
21576115-9	2011	Plasma cholinesterase activity correlated positively with calcium and haemoglobin and negatively with total bilirubin and international normalised ratio.	Bilirubin	108-117	butyrylcholinesterase	Homo sapiens	7-21
21615622-4	2011	Among the genes involved in bile acid and bilirubin transport, the expression of SLCO1B3 was significantly elevated in HCC with CTNNB1 mutations, whereas the expression of ABCC4 was elevated in HCC with wild-type CTNNB1.	Bilirubin	42-51	solute carrier organic anion transporter family member 1B3	Homo sapiens	81-88
21642499-1	2011	Liver growth factor (LGF) is an endogenous albumin-bilirubin complex with antihypertensive effects in spontaneously hypertensive rats (SHR).	Bilirubin	51-60	myotrophin	Rattus norvegicus	6-19
21500146-6	2011	In male infants with the 388 A G mutation of the OATP-2 gene, the levels of unconjugated bilirubin in plasma were significantly increased compared with those observed in females.	Bilirubin	89-98	solute carrier organic anion transporter family member 1B1	Homo sapiens	49-55
21615622-4	2011	Among the genes involved in bile acid and bilirubin transport, the expression of SLCO1B3 was significantly elevated in HCC with CTNNB1 mutations, whereas the expression of ABCC4 was elevated in HCC with wild-type CTNNB1.	Bilirubin	42-51	ATP binding cassette subfamily C member 4	Homo sapiens	172-177
21631904-9	2011	Serum TBil concentrations were inversely associated with hyperinsulinemia, insulin resistance, and systemic inflammation.	Bilirubin	6-10	insulin	Homo sapiens	62-69
21631904-10	2011	CONCLUSIONS: Serum TBil concentrations within the physiological range were inversely associated with MS and insulin resistance, hyperinsulinemia, and systemic inflammation in middle-aged and elderly Chinese.	Bilirubin	19-23	insulin	Homo sapiens	108-115
21861928-6	2011	RESULTS: We demonstrated that PPCSE (30 mug/ml) significantly induced HO-1 protein expression and its enzymatic activity in bEnd.3 cells determined by western blotting and bilirubin formation, respectively.	Bilirubin	172-181	heme oxygenase 1	Mus musculus	70-74
25755316-10	2011	Treatment with P. amarus along with CCl4 significantly mitigated the increase in activities of liver marker enzymes, lipid peroxidation, and bilirubin content.	Bilirubin	141-150	chemokine (C-C motif) ligand 4	Mus musculus	36-40
21635873-5	2011	Interestingly, the glutathione donor N-acetyl-l-cysteine or the NADPH oxidase inhibitor apocynin blocked the induction of HO-1 by compound C. Finally, compound C stimulated EC death and this was potentiated by silencing HO-1 expression and reversed by the administration of CO, biliverdin, or bilirubin.	Bilirubin	293-302	heme oxygenase 1	Homo sapiens	122-126
22745870-0	2011	Association of Serum Total Bilirubin with Serum High Sensitivity C-reactive Protein in Middle-aged Men.	Bilirubin	27-36	C-reactive protein	Homo sapiens	65-83
21849978-5	2011	Here we use newly characterized genetically modified kidney mouse cells in which Fh1 has been deleted, and apply a newly developed computer model of the metabolism of these cells to predict and experimentally validate a linear metabolic pathway beginning with glutamine uptake and ending with bilirubin excretion from Fh1-deficient cells.	Bilirubin	293-302	fumarate hydratase 1	Mus musculus	81-84
21849978-5	2011	Here we use newly characterized genetically modified kidney mouse cells in which Fh1 has been deleted, and apply a newly developed computer model of the metabolism of these cells to predict and experimentally validate a linear metabolic pathway beginning with glutamine uptake and ending with bilirubin excretion from Fh1-deficient cells.	Bilirubin	293-302	fumarate hydratase 1	Mus musculus	318-321
21765449-10	2011	Rank correlation analysis revealed a significant correlation between serum RCOR3 level and total bilirubin (r=-0.305, P&lt;0.01).	Bilirubin	97-106	REST corepressor 3	Homo sapiens	75-80
21295138-5	2011	The biological and physiological implications of PXR activation are broad, ranging from drug metabolism and drug-drug interactions to the homeostasis of numerous endobiotics, such as glucose, lipids, steroids, bile acids, bilirubin, retinoic acid, and bone minerals.	Bilirubin	222-231	nuclear receptor subfamily 1 group I member 2	Homo sapiens	49-52
21596993-8	2011	In NK-1R (-)/(-) BDL mice, there was a decrease in serum transaminases and bilirubin levels and the number of CK-19-positive cholangiocytes and enhanced biliary apoptosis compared with controls.	Bilirubin	75-84	tachykinin receptor 1	Mus musculus	3-8
21420387-8	2011	(ii) CAR-mediated induction of UGT1A1 may be involved in perinatal detoxification of bilirubin neurotoxicity.	Bilirubin	85-94	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	31-37
21813008-4	2011	Multidrug resistance protein 2 (MRP2) is one of the canalicular export pumps located in hepatocytes; it exports organic anions and their conjugates (e.g., bilirubin) into bile canaliculus.	Bilirubin	155-164	ATP binding cassette subfamily C member 2	Homo sapiens	0-30
21813008-4	2011	Multidrug resistance protein 2 (MRP2) is one of the canalicular export pumps located in hepatocytes; it exports organic anions and their conjugates (e.g., bilirubin) into bile canaliculus.	Bilirubin	155-164	ATP binding cassette subfamily C member 2	Homo sapiens	32-36
21813008-5	2011	Although MRP2 is an essential transporter for the excretion of bilirubin, its role in the clinical course of BA patients is unclear.	Bilirubin	63-72	ATP binding cassette subfamily C member 2	Homo sapiens	9-13
21813008-11	2011	Furthermore, MRP2 expression level was inversely correlated with ratio of change in serum total bilirubin level over 4 weeks (rs = -0.676, p = 0.008), which represents the serum bilirubin level measured at 4 weeks after surgery divided by value just before surgery.	Bilirubin	96-105	ATP binding cassette subfamily C member 2	Homo sapiens	13-17
21813008-11	2011	Furthermore, MRP2 expression level was inversely correlated with ratio of change in serum total bilirubin level over 4 weeks (rs = -0.676, p = 0.008), which represents the serum bilirubin level measured at 4 weeks after surgery divided by value just before surgery.	Bilirubin	178-187	ATP binding cassette subfamily C member 2	Homo sapiens	13-17
21873967-5	2011	CHE was also directly correlated to cholesterol, iron binding capacity, hematocrit, prothrombin activity, and inversely correlated to bilirubin and to presence of sepsis or liver dysfunction (P&lt;0.0001 for all).	Bilirubin	134-143	butyrylcholinesterase	Homo sapiens	0-3
21852972-12	2011	Increased C-reactive protein and gamma-glutamyl transferase levels were associated with decreased protein expression of both enzymes, and increased bilirubin levels, cholestasis, and presurgical exposure to omeprazole or pantoprazole were related to decreased PON3 protein.	Bilirubin	148-157	C-reactive protein	Homo sapiens	10-28
22169899-1	2011	The UGT1A1 gene encodes a responsible enzyme, UDP-glucuronosyltransferase1A1, for bilirubin metabolism.	Bilirubin	82-91	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	4-10
22169899-1	2011	The UGT1A1 gene encodes a responsible enzyme, UDP-glucuronosyltransferase1A1, for bilirubin metabolism.	Bilirubin	82-91	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	46-76
21412181-2	2011	Two patients during clinical development met laboratory, but not clinical, criteria for Hy"s law with bilirubin elevations suspected as a result of genetic variation in uridine diphosphoglucose glucuronosyltransferase (UGT1A1) typical of Gilbert syndrome.	Bilirubin	102-111	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	219-225
21593686-8	2011	HO-1 activity was determined in microsomal fractions from HUVECs by monitoring the conversion of heme into bilirubin.	Bilirubin	107-116	heme oxygenase 1	Homo sapiens	0-4
21412181-7	2011	UGT1A1*28 and three additional single nucleotide polymorphisms showed odds ratios greater than 25 for associations with elevated bilirubin.	Bilirubin	129-138	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
21412181-10	2011	Thus, in the absence of other signs of hepatic dysfunction, bilirubin elevations after treatment with tocilizumab have a high probability of association with UGT1A1 polymorphism, which should alleviate concerns of serious hepatotoxicity.	Bilirubin	60-69	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	158-164
21671781-11	2011	CONCLUSIONS: Total bilirubin level appears to be inversely associated with the prevalence of MetS in rural Korean women &gt;40 years of age in the KGRC, even after adjusting for risk factors of MetS, including body mass index (BMI), menopausal status, CRP levels, and homeostasis model assessment of insulin resistance (HOMA-IR).	Bilirubin	19-28	C-reactive protein	Homo sapiens	252-255
23569758-9	2011	RESULTS: The result of present study suggested that CCl4 administration increased the level of SGOT and SGPT and bilirubin level in serum.	Bilirubin	113-122	chemokine (C-C motif) ligand 4	Mus musculus	52-56
23569758-10	2011	However, the aqueous extract of turmeric reduced the level of SGOT, SGPT and bilirubin in CCl4 intoxicated mice.	Bilirubin	77-86	chemokine (C-C motif) ligand 4	Mus musculus	90-94
21419123-0	2011	Pro-inflammatory cytokines intensify the activation of NO/NOS, JNK1/2 and caspase cascades in immature neurons exposed to elevated levels of unconjugated bilirubin.	Bilirubin	154-163	mitogen-activated protein kinase 8	Homo sapiens	63-81
21622183-4	2011	HO-1 represses inflammation by removing the pro-inflammatory molecule heme and by generating CO and the bile pigments, biliverdin and bilirubin.	Bilirubin	134-143	heme oxygenase 1	Homo sapiens	0-4
21671781-11	2011	CONCLUSIONS: Total bilirubin level appears to be inversely associated with the prevalence of MetS in rural Korean women &gt;40 years of age in the KGRC, even after adjusting for risk factors of MetS, including body mass index (BMI), menopausal status, CRP levels, and homeostasis model assessment of insulin resistance (HOMA-IR).	Bilirubin	19-28	insulin	Homo sapiens	300-307
21266593-2	2011	The development of UGT1A1 and 1A6 was studied in 50 pediatric liver samples using bilirubin, serotonin activity assays, and Western blot as well as pharmacokinetic scaling.	Bilirubin	82-91	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	19-33
21345995-2	2011	The heme oxygenase system (HO-1 and HO-2) represents an intrinsic cytoprotective and anti-inflammatory pathway based on its ability to modulate leukocyte migration and to inhibit the expression of inflammatory cytokines and proteins by its products biliverdin/bilirubin and carbon monoxide.	Bilirubin	260-269	heme oxygenase 1	Mus musculus	27-31
21345995-2	2011	The heme oxygenase system (HO-1 and HO-2) represents an intrinsic cytoprotective and anti-inflammatory pathway based on its ability to modulate leukocyte migration and to inhibit the expression of inflammatory cytokines and proteins by its products biliverdin/bilirubin and carbon monoxide.	Bilirubin	260-269	heme oxygenase 2	Mus musculus	36-40
21383306-1	2011	Recent in vitro studies have reported that heme oxygenase 1 (HO-1) downregulates the angiostatic protein soluble fms-like tyrosine kinase 1 from placental villous explants and that the HO-1 metabolites CO and bilirubin negatively regulate endothelin 1 and reactive oxygen species.	Bilirubin	209-218	heme oxygenase 1	Rattus norvegicus	43-59
21383306-1	2011	Recent in vitro studies have reported that heme oxygenase 1 (HO-1) downregulates the angiostatic protein soluble fms-like tyrosine kinase 1 from placental villous explants and that the HO-1 metabolites CO and bilirubin negatively regulate endothelin 1 and reactive oxygen species.	Bilirubin	209-218	heme oxygenase 1	Rattus norvegicus	61-65
21383306-1	2011	Recent in vitro studies have reported that heme oxygenase 1 (HO-1) downregulates the angiostatic protein soluble fms-like tyrosine kinase 1 from placental villous explants and that the HO-1 metabolites CO and bilirubin negatively regulate endothelin 1 and reactive oxygen species.	Bilirubin	209-218	heme oxygenase 1	Rattus norvegicus	185-189
21641490-2	2011	The combination of these auditory measures suggests that bilirubin exposure results in auditory system damage initially at the level of the brainstem, progressing to the level of the VIII cranial nerve and then to greater neural centers.	Bilirubin	57-66	cytochrome c oxidase subunit 8A	Homo sapiens	183-187
21552471-1	2011	PURPOSE: Heme oxygenase (HO)-2 is highly expressed in the corneal epithelium and is a component of the heme oxygenase system that represents an intrinsic cytoprotective and anti-inflammatory system based on its ability to modulate leukocyte migration and to inhibit expression of inflammatory cytokines and proteins via its products biliverdin/bilirubin and carbon monoxide (CO).	Bilirubin	344-353	heme oxygenase 2	Mus musculus	9-30
21538282-5	2011	Linkage and case-control studies of candidate genes and recent genome-wide studies have identified multiple lithogenic genes, in particular the hepatocanalicular cholesterol transporter ABCG5/G8 and the bilirubin conjugating enzyme UGT1A1, as major genetic determinants of gallstones in humans.	Bilirubin	203-212	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	232-238
21505270-9	2011	In ACHBLF patients, the level of IFN-gamma was positively correlated with total bilirubin and MELD score, but negatively correlated with prothrombin time activity.	Bilirubin	80-89	interferon gamma	Homo sapiens	33-42
21241799-1	2011	Biliverdin reductase-A is a pleiotropic enzyme involved not only in the reduction of biliverdin-IX-alpha into bilirubin-IX-alpha, but also in the regulation of glucose metabolism and cell growth secondary to its serine/threonine/tyrosine kinase activity.	Bilirubin	110-119	biliverdin reductase A	Homo sapiens	0-22
21528085-6	2011	The percentage of late apoptotic marrow CD34+ cells was positively correlated with the total bilirubin and aspartate aminotransferase serum levels in patients with cirrhosis.	Bilirubin	93-102	CD34 molecule	Homo sapiens	40-44
21513526-2	2011	Previous genetic studies have focused on the UGT1A1 gene, associating common variation in the coding or promoter regions with qualitative assessments of bilirubin (i.e. significantly elevated or not).	Bilirubin	153-162	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	45-51
21513526-5	2011	We apply this approach to the UGT1A1 gene--exploring the contribution of both rare and common variants to early bilirubin changes.	Bilirubin	112-121	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	30-36
21513526-9	2011	CONCLUSIONS: Collectively, rare UGT1A1 coding variants do not appear to play a prominent role in determining early bilirubin levels; however common variants in the 3" UTR of UGT1A1 may modulate the early bilirubin rise.	Bilirubin	204-213	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	174-180
20637009-10	2011	RESULTS: The CSF biomarkers for neuronal/axonal damage (tau and neurofilament protein), glial cell injury (GFAP and S-100b), blood-brain barrier damage (CSF/serum albumin ratio) and hemorrhages (hemoglobin and bilirubin) and the serum GFAP and S-100b showed normal and stable levels in all exposed officers.	Bilirubin	210-219	colony stimulating factor 2	Homo sapiens	13-16
21353662-7	2011	Variants of the gene encoding UGT1A1 (uridine 5"-diphosphate (UDP)-glucuronosyltransferase 1A1) responsible for bilirubin conjugation were recently associated with risk of gallstones as well as stone bilirubin content, suggesting common factors in cholesterol and pigment gallstone pathogenesis.	Bilirubin	112-121	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	30-36
21198546-8	2011	Both products of the HO-1 reaction, CO and bilirubin, inhibited (by 30-40%) NFAT3 activation and production of the pro-apoptotic proteins Bcl-XS/Bax.	Bilirubin	43-52	heme oxygenase 1	Rattus norvegicus	21-25
21198546-8	2011	Both products of the HO-1 reaction, CO and bilirubin, inhibited (by 30-40%) NFAT3 activation and production of the pro-apoptotic proteins Bcl-XS/Bax.	Bilirubin	43-52	BCL2 associated X, apoptosis regulator	Rattus norvegicus	145-148
21353662-7	2011	Variants of the gene encoding UGT1A1 (uridine 5"-diphosphate (UDP)-glucuronosyltransferase 1A1) responsible for bilirubin conjugation were recently associated with risk of gallstones as well as stone bilirubin content, suggesting common factors in cholesterol and pigment gallstone pathogenesis.	Bilirubin	112-121	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	38-94
21353662-7	2011	Variants of the gene encoding UGT1A1 (uridine 5"-diphosphate (UDP)-glucuronosyltransferase 1A1) responsible for bilirubin conjugation were recently associated with risk of gallstones as well as stone bilirubin content, suggesting common factors in cholesterol and pigment gallstone pathogenesis.	Bilirubin	200-209	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	30-36
21353662-7	2011	Variants of the gene encoding UGT1A1 (uridine 5"-diphosphate (UDP)-glucuronosyltransferase 1A1) responsible for bilirubin conjugation were recently associated with risk of gallstones as well as stone bilirubin content, suggesting common factors in cholesterol and pigment gallstone pathogenesis.	Bilirubin	200-209	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	38-94
21255081-6	2011	Bilirubin concentrations were significantly higher among individuals with compound heterozygous variations/homozygous variation in the UGT1A1 gene than in those possessing the wild type and heterozygous variation (P &lt; 0.001 for both alpha- and beta-thalassemia heterozygotes).	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	135-141
21198350-0	2011	Association of (GT)n repeats promoter polymorphism of heme oxygenase-1 gene with serum bilirubin levels in healthy Indian adults.	Bilirubin	87-96	heme oxygenase 1	Homo sapiens	54-70
21198350-1	2011	AIM: The present study was undertaken to investigate a length polymorphism of (GT)n repeats of the heme oxygenase-1 (HMOX-1) gene and its association with serum bilirubin levels in apparently healthy adults.	Bilirubin	161-170	heme oxygenase 1	Homo sapiens	99-115
21198350-1	2011	AIM: The present study was undertaken to investigate a length polymorphism of (GT)n repeats of the heme oxygenase-1 (HMOX-1) gene and its association with serum bilirubin levels in apparently healthy adults.	Bilirubin	161-170	heme oxygenase 1	Homo sapiens	117-123
21255081-8	2011	CONCLUSIONS:   The difference in bilirubin concentrations between alpha- and beta-thalassemia heterozygotes may be attributable to more bilirubin being produced in beta-thalassemia heterozygotes than in alpha-thalassemia heterozygotes, while variation status of the UGT1A1 gene affects bilirubin concentrations in both alpha- and beta-thalassemia heterozygotes.	Bilirubin	33-42	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	266-272
21255081-8	2011	CONCLUSIONS:   The difference in bilirubin concentrations between alpha- and beta-thalassemia heterozygotes may be attributable to more bilirubin being produced in beta-thalassemia heterozygotes than in alpha-thalassemia heterozygotes, while variation status of the UGT1A1 gene affects bilirubin concentrations in both alpha- and beta-thalassemia heterozygotes.	Bilirubin	136-145	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	266-272
21255081-8	2011	CONCLUSIONS:   The difference in bilirubin concentrations between alpha- and beta-thalassemia heterozygotes may be attributable to more bilirubin being produced in beta-thalassemia heterozygotes than in alpha-thalassemia heterozygotes, while variation status of the UGT1A1 gene affects bilirubin concentrations in both alpha- and beta-thalassemia heterozygotes.	Bilirubin	136-145	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	266-272
21464924-8	2011	In contrast, there was no evidence for reduced amino acid constraint for these same species within UGT1A1, the gene encoding the enzyme responsible for detoxification of endogenously generated bilirubin.	Bilirubin	193-202	UDP-glucuronosyltransferase 1-1	Felis catus	99-105
21401897-9	2011	Linear correlation analysis demonstrated significant correlations between TLR-3 level and disease severity markers (total bilirubin, prothrombin activity, creatinine, white blood cell count, and maximum volume of ascitic fluid) in individual CSHB patients.	Bilirubin	122-131	toll like receptor 3	Homo sapiens	74-79
21448202-3	2011	Heme oxygenase (HO), with inducible (HO-1) and constitutive (HO-2) isoenzymes, is the rate-limiting enzyme in heme catabolism, producing equimolar amounts of bilirubin and carbon monoxide (CO).	Bilirubin	158-167	heme oxygenase 1	Rattus norvegicus	37-41
21448202-3	2011	Heme oxygenase (HO), with inducible (HO-1) and constitutive (HO-2) isoenzymes, is the rate-limiting enzyme in heme catabolism, producing equimolar amounts of bilirubin and carbon monoxide (CO).	Bilirubin	158-167	heme oxygenase 2	Rattus norvegicus	61-65
21448202-7	2011	Although bilirubin production is due to the activity of both HO-1 and HO-2, the inhibition of HO-1 with a relative sparing of HO-2 activity might provide the most selective approach for the treatment of hemolytic disease.	Bilirubin	9-18	heme oxygenase 1	Rattus norvegicus	61-74
21448202-7	2011	Although bilirubin production is due to the activity of both HO-1 and HO-2, the inhibition of HO-1 with a relative sparing of HO-2 activity might provide the most selective approach for the treatment of hemolytic disease.	Bilirubin	9-18	heme oxygenase 1	Rattus norvegicus	61-65
21448202-7	2011	Although bilirubin production is due to the activity of both HO-1 and HO-2, the inhibition of HO-1 with a relative sparing of HO-2 activity might provide the most selective approach for the treatment of hemolytic disease.	Bilirubin	9-18	heme oxygenase 2	Rattus norvegicus	70-74
21392402-8	2011	The percentage of Tim-3+ T cells was further increased in SCHB patients relative to MCHB patients and showed a positive correlation with conventional markers for liver injury (alanine aminotransferase (ALT), aspartate transaminase (AST), total bilirubin (TB) and international normalized ratio (INR) level).	Bilirubin	244-253	hepatitis A virus cellular receptor 2	Homo sapiens	18-23
21238463-12	2011	HIF-1alpha downstream target heme oxygenase 1 (HMOX-1) was upregulated in skeletal muscle, while serum bilirubin was increased.	Bilirubin	103-112	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
21392402-8	2011	The percentage of Tim-3+ T cells was further increased in SCHB patients relative to MCHB patients and showed a positive correlation with conventional markers for liver injury (alanine aminotransferase (ALT), aspartate transaminase (AST), total bilirubin (TB) and international normalized ratio (INR) level).	Bilirubin	255-257	hepatitis A virus cellular receptor 2	Homo sapiens	18-23
21411679-0	2011	Serum bilirubin links UGT1A1*28 polymorphism and predicts long-term cardiovascular events and mortality in chronic hemodialysis patients.	Bilirubin	6-15	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	22-28
21167147-5	2011	Unconjugated bilirubin was negatively correlated with sd-LDL-C, ox-LDL and hs-CRP (r=-0.594, p&lt;0.001; r=-0.249, p=0.016 and r=-0.373, p&lt;0.001 respectively).	Bilirubin	13-22	C-reactive protein	Homo sapiens	78-81
21411679-2	2011	Bilirubin degradation is mainly determined by the activity of hepatic bilirubin uridine diphosphate-glucuronosyltransferase (UGT1A1), which is significantly influenced by a TA-repeat polymorphism in the gene"s promoter, an allele designated UGT1A1*28.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	125-131
21411679-2	2011	Bilirubin degradation is mainly determined by the activity of hepatic bilirubin uridine diphosphate-glucuronosyltransferase (UGT1A1), which is significantly influenced by a TA-repeat polymorphism in the gene"s promoter, an allele designated UGT1A1*28.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	241-247
21411679-3	2011	The study aimed to clarify the association between serum bilirubin and UGT1A1*28 polymorphism and their respective effect on outcomes of chronic hemodialysis patients.	Bilirubin	57-66	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	71-77
21411679-7	2011	Individuals homozygous for UGT1A1*28 (genotype 7/7) had significantly higher bilirubin levels than those with 6/6 and 7/6 genotypes.	Bilirubin	77-86	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	27-33
21411679-10	2011	Moreover, the UGT1A1*28 polymorphism had strong effects on bilirubin levels and the 7/7 genotype might have an important effect on reducing CVEs and death.	Bilirubin	59-68	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	14-20
21468552-4	2011	UDP-glucuronosyltransferase (UGT)1A1 is a conjugating biotransformation enzyme that plays a role in maintaining the levels of endogenous compounds (e.g., bilirubin) and in handling exogenous compounds, including carcinogens.	Bilirubin	154-163	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	29-36
20563825-1	2011	Heme oxygenase-1 (HO-1), a 32 kDa stress protein mediating the degradation of heme to ferrous iron, carbon monoxide and biliverdin/bilirubin, has been implicated in the pathogenesis of Alzheimer disease (AD) and other aging-related neurodegenerative disorders.	Bilirubin	131-140	heme oxygenase 1	Homo sapiens	0-16
20563825-1	2011	Heme oxygenase-1 (HO-1), a 32 kDa stress protein mediating the degradation of heme to ferrous iron, carbon monoxide and biliverdin/bilirubin, has been implicated in the pathogenesis of Alzheimer disease (AD) and other aging-related neurodegenerative disorders.	Bilirubin	131-140	heme oxygenase 1	Homo sapiens	18-22
21332248-1	2011	BACKGROUND: The most specific indicator of a drug-induced liver injury signal in a clinical trial database is believed to be the occurrence of subjects experiencing drug-associated elevations in both serum ALT and serum total bilirubin (TB) without a significant elevation in serum alkaline phosphatase (ALP).	Bilirubin	226-235	alkaline phosphatase, placental	Homo sapiens	282-302
21332248-1	2011	BACKGROUND: The most specific indicator of a drug-induced liver injury signal in a clinical trial database is believed to be the occurrence of subjects experiencing drug-associated elevations in both serum ALT and serum total bilirubin (TB) without a significant elevation in serum alkaline phosphatase (ALP).	Bilirubin	226-235	alkaline phosphatase, placental	Homo sapiens	304-307
21356120-11	2011	Subsequent analysis revealed that serum adiponectin was positively correlated with total bilirubin, hyaluronic acid, and liver stiffness (r = 0.58, r = 0.46, and r = 0.60, P &lt; 0.001, respectively).	Bilirubin	89-98	adiponectin, C1Q and collagen domain containing	Homo sapiens	40-51
21046114-9	2011	In addition, circulating osteopontin was positively correlated with serum total bilirubin (r = 0.526, P &lt; 0.001) and with serum ALT (r = 0.575, P &lt; 0.001).	Bilirubin	80-89	secreted phosphoprotein 1	Homo sapiens	25-36
20965681-9	2011	In the presence of bilirubin (concentration range 0.5-5 muM), Kd(app) of MPA was approximately 1.5-5-fold greater than MPA Kd.	Bilirubin	19-28	latexin	Homo sapiens	56-59
20965681-9	2011	In the presence of bilirubin (concentration range 0.5-5 muM), Kd(app) of MPA was approximately 1.5-5-fold greater than MPA Kd.	Bilirubin	19-28	amyloid beta precursor protein	Homo sapiens	62-69
20965681-10	2011	For bilirubin/albumin molar ratio reachable in clinical settings (1:4 and 1:2), Kd(app) of MPA rose about a factor 1.5 and 1.9, respectively.	Bilirubin	4-13	amyloid beta precursor protein	Homo sapiens	80-87
21095216-9	2011	Liver injury by TCDD plus BDL, such as increased plasma bile acids, bilirubin and aminotransferases, liver necrosis, and increased tumor necrosis factor production, was exaggerated in Cyp1a1/1a2(-/-) double knockout mice.	Bilirubin	68-77	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	184-190
21030469-0	2011	Correlation between bilirubin glucuronidation and estradiol-3-gluronidation in the presence of model UDP-glucuronosyltransferase 1A1 substrates/inhibitors.	Bilirubin	20-29	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	101-132
21395542-1	2011	Eleven members of the human organic anion transporter (OATP) family (grouped into six families) facilitate the Na(+)- independent transmembrane transport of various endo- and xenobiotics (bile acids, bilirubin, steroid hormone conjugates, thyroid hormones, prostaglandins, clinically used drugs, and toxins).	Bilirubin	200-209	solute carrier organic anion transporter family member 1A2	Homo sapiens	28-53
21395542-1	2011	Eleven members of the human organic anion transporter (OATP) family (grouped into six families) facilitate the Na(+)- independent transmembrane transport of various endo- and xenobiotics (bile acids, bilirubin, steroid hormone conjugates, thyroid hormones, prostaglandins, clinically used drugs, and toxins).	Bilirubin	200-209	solute carrier organic anion transporter family member 1A2	Homo sapiens	55-59
21030469-1	2011	Inhibition of UDP-glucuronosyltransferase (UGT) 1A1-catalyzed bilirubin glucuronidation by drug compounds may potentially be of clinical concern.	Bilirubin	62-71	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	14-51
21030469-5	2011	The glucuronidation kinetics of bilirubin and estradiol were carefully characterized with recombinant UGT1A1 expressed in human embryonic kidney 293 cells.	Bilirubin	32-41	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	102-108
21030469-11	2011	In addition, 7-ethyl-10-hydroxycamptothecin, a substrate of UGT1A1 (reported K(m) = 24 muM) seemed to be a weak inhibitor of bilirubin glucuronidation (IC(50) = 356.4 muM) but a partial inhibitor of estradiol-3-glucuronidation.	Bilirubin	125-134	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	60-66
21030469-11	2011	In addition, 7-ethyl-10-hydroxycamptothecin, a substrate of UGT1A1 (reported K(m) = 24 muM) seemed to be a weak inhibitor of bilirubin glucuronidation (IC(50) = 356.4 muM) but a partial inhibitor of estradiol-3-glucuronidation.	Bilirubin	125-134	latexin	Homo sapiens	87-90
21842368-4	2011	HO-1 is a microsomal enzyme that catalyses the degradation of heme to iron, carbon monoxide and bilirubin.	Bilirubin	96-105	heme oxygenase 1	Mus musculus	0-4
21614935-1	2011	Bilirubin is glucoronized by uridine diphosphate-glucuronosyl transferase 1A1 (UGT1A1) mainly in the liver, and excreted into bile.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	29-77
21614935-1	2011	Bilirubin is glucoronized by uridine diphosphate-glucuronosyl transferase 1A1 (UGT1A1) mainly in the liver, and excreted into bile.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	79-85
20975617-7	2011	Neonates with nucleotide 211 GA or AA variation in UGT1A1 genotypes had higher peak serum bilirubin levels and higher incidence of hyperbilirubinemia than WTs (GG).	Bilirubin	90-99	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	51-57
21342629-0	2011	[Effect of bilirubin on expression of toll-like receptor 4 in cord blood monocytes].	Bilirubin	11-20	toll like receptor 4	Bos taurus	38-58
21342629-1	2011	OBJECTIVE: To study the effect of different concentrations of bilirubin on expression of toll-like receptor 4 (TLR4) in cord blood monocytes (CBMC).	Bilirubin	62-71	toll like receptor 4	Bos taurus	89-109
21342629-1	2011	OBJECTIVE: To study the effect of different concentrations of bilirubin on expression of toll-like receptor 4 (TLR4) in cord blood monocytes (CBMC).	Bilirubin	62-71	toll like receptor 4	Bos taurus	111-115
21342629-6	2011	RESULTS: Bilirubin at the concentrations of 102.6, 153.9, 220.6 and 307.8 mumol/L inhibited the expression of TLR4 of CBMC.	Bilirubin	9-18	toll like receptor 4	Bos taurus	110-114
21342629-8	2011	CONCLUSIONS: Bilirubin can inhibit the TLR4 expression of CBNC in a dose-dependent manner.	Bilirubin	13-22	toll like receptor 4	Bos taurus	39-43
21099244-1	2011	Biliverdin reductase A (BLVRA), an enzyme that converts biliverdin to bilirubin, has recently emerged as a key regulator of the cellular redox cycle.	Bilirubin	70-79	biliverdin reductase A	Homo sapiens	0-22
21099244-1	2011	Biliverdin reductase A (BLVRA), an enzyme that converts biliverdin to bilirubin, has recently emerged as a key regulator of the cellular redox cycle.	Bilirubin	70-79	biliverdin reductase A	Homo sapiens	24-29
21297965-0	2011	Modulation of Mrp1 (ABCc1) and Pgp (ABCb1) by bilirubin at the blood-CSF and blood-brain barriers in the Gunn rat.	Bilirubin	46-55	ATP binding cassette subfamily C member 1	Rattus norvegicus	14-18
21297965-0	2011	Modulation of Mrp1 (ABCc1) and Pgp (ABCb1) by bilirubin at the blood-CSF and blood-brain barriers in the Gunn rat.	Bilirubin	46-55	ATP binding cassette subfamily C member 1	Rattus norvegicus	20-25
21297965-0	2011	Modulation of Mrp1 (ABCc1) and Pgp (ABCb1) by bilirubin at the blood-CSF and blood-brain barriers in the Gunn rat.	Bilirubin	46-55	phosphoglycolate phosphatase	Rattus norvegicus	31-34
21297965-0	2011	Modulation of Mrp1 (ABCc1) and Pgp (ABCb1) by bilirubin at the blood-CSF and blood-brain barriers in the Gunn rat.	Bilirubin	46-55	ATP binding cassette subfamily B member 1A	Rattus norvegicus	36-41
21081499-2	2011	This antioxidant activity is thought to result from the HO-1 enzymatic activity, manifested by a decrease in the concentration of the pro-oxidant substrate heme, and an increase in the antioxidant product bilirubin.	Bilirubin	205-214	heme oxygenase 1	Homo sapiens	56-60
21141881-2	2011	Preferential binding of the P- or M-helical conformer of bilirubin to dehydrogenases, catalase, alkaline phosphatase, and alpha-chymotrypsin is responsible for the characteristic exciton CD couplet that undergoes remarkable changes upon the addition of enzymatic cofactors (NADH, AMP) and an inhibitor (acridine).	Bilirubin	57-66	catalase	Homo sapiens	86-94
21141881-3	2011	Alterations of the ICD spectra refer to a direct binding competition between bilirubin and NADH for a common binding site on alcohol dehydrogenase and catalase, suggesting a potential mechanism for the inhibitory effect of BR reported on NAD(P)H dependent enzymes.	Bilirubin	77-86	catalase	Homo sapiens	151-159
21080475-3	2011	Genetic variation within the promoter region of uridine diphosphate glucuronosyltransferase (UGT1A1) on chromosome 2q has been associated with elevated serum bilirubin levels in European populations.	Bilirubin	158-167	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	93-99
21080475-10	2011	CONCLUSIONS: Replication of a serum bilirubin QTL on chromosome 2q in American Indians implicates UGT1A1 but further genotyping is warranted to identify additional causative polymorphisms.	Bilirubin	36-45	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	98-104
23461146-1	2011	The UDP-glucuronosyltransferase 1A1 gene that encode the enzyme UGT1A1 responsible for glucuronidation undergoes several variations that may affect the enzymatic activity or expression and which are the cause of metabolic disorders related to the glucuronidation of bilirubin, such as Gilbert"s syndrome and Crigler Najjar"s syndrome.	Bilirubin	266-275	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	4-35
20422170-1	2011	Heme oxygenase-1 (HO-1), an inducible enzyme, degrades heme to carbon monoxide (CO), iron, and bilirubin.	Bilirubin	95-104	heme oxygenase 1	Rattus norvegicus	0-16
20422170-1	2011	Heme oxygenase-1 (HO-1), an inducible enzyme, degrades heme to carbon monoxide (CO), iron, and bilirubin.	Bilirubin	95-104	heme oxygenase 1	Rattus norvegicus	18-22
23461146-1	2011	The UDP-glucuronosyltransferase 1A1 gene that encode the enzyme UGT1A1 responsible for glucuronidation undergoes several variations that may affect the enzymatic activity or expression and which are the cause of metabolic disorders related to the glucuronidation of bilirubin, such as Gilbert"s syndrome and Crigler Najjar"s syndrome.	Bilirubin	266-275	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	64-70
20876213-1	2011	HO-2 oxidizes heme to CO and biliverdin; the latter is reduced to bilirubin by biliverdin reductase (BVR).	Bilirubin	66-75	heme oxygenase 2	Homo sapiens	0-4
21050771-9	2011	CONCLUSIONS: Infestation of Demodex mites induces change of tear cytokine levels, IL-17 especially, which cause inflammation of the lid margin and ocular surface.	Bilirubin	28-41	interleukin 17A	Homo sapiens	82-87
21212670-11	2011	Serum biochemistry changes associated with MX-ALC treatment consisted of a significant (p &lt; 0.05) increase in AST with MX at 6 or 9 mg kg(-1) plus ALC 200 mg kg(-1) and a significant (p &lt; 0.05) reduction in total protein compared to the corresponding MX group; serum albumin and bilirubin remained unchanged.	Bilirubin	285-294	allantoicase	Mus musculus	46-49
21304237-9	2011	In contrast, patients with positive autoimmune antibodies (anti-nuclear antibodies and/or soluble liver antigen) and/or histological features of chronic hepatitis (n = 3) exhibited a slower reduction in bilirubin and serum transaminase levels.	Bilirubin	203-212	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase	Homo sapiens	90-111
20876213-1	2011	HO-2 oxidizes heme to CO and biliverdin; the latter is reduced to bilirubin by biliverdin reductase (BVR).	Bilirubin	66-75	biliverdin reductase A	Homo sapiens	79-99
20876213-1	2011	HO-2 oxidizes heme to CO and biliverdin; the latter is reduced to bilirubin by biliverdin reductase (BVR).	Bilirubin	66-75	biliverdin reductase A	Homo sapiens	101-104
21681009-8	2011	CONCLUSIONS: CK-7 expression is a sensitive marker of bile duct injury, which correlated well with histological stages of primary biliary cirrhosis, copper deposits, and biochemical markers of cholestasis: serum bilirubin level and alkaline phosphatase activity.	Bilirubin	212-221	keratin 7	Homo sapiens	13-17
21417577-0	2011	Bilirubin peak can be mistaken as Hb Bart"s or Hb H on High-performance liquid chromatography.	Bilirubin	0-9	barttin CLCNK type accessory subunit beta	Homo sapiens	37-41
21417577-2	2011	However, one needs to be vigilant to pick up undue interference such as the presence of a bilirubin peak, which can be mistaken for either Hb Bart"s or Hb H on Hb HPLC.	Bilirubin	90-99	barttin CLCNK type accessory subunit beta	Homo sapiens	142-146
20797999-8	2011	Meanwhile, catalase (CAT) and ascorbate peroxidase (APX) activities or transcripts were enhanced by haematin, CO, or bilirubin (BR), the catalytic by-product of HO.	Bilirubin	117-126	catalase-1	Triticum aestivum	11-19
20797999-8	2011	Meanwhile, catalase (CAT) and ascorbate peroxidase (APX) activities or transcripts were enhanced by haematin, CO, or bilirubin (BR), the catalytic by-product of HO.	Bilirubin	117-126	catalase-1	Triticum aestivum	21-24
20797999-8	2011	Meanwhile, catalase (CAT) and ascorbate peroxidase (APX) activities or transcripts were enhanced by haematin, CO, or bilirubin (BR), the catalytic by-product of HO.	Bilirubin	117-126	peroxidase-like	Triticum aestivum	40-50
20797999-8	2011	Meanwhile, catalase (CAT) and ascorbate peroxidase (APX) activities or transcripts were enhanced by haematin, CO, or bilirubin (BR), the catalytic by-product of HO.	Bilirubin	117-126	APX	Triticum aestivum	52-55
20967881-0	2011	Astrocyte reactivity to unconjugated bilirubin requires TNF-alpha and IL-1beta receptor signaling pathways.	Bilirubin	37-46	tumor necrosis factor	Rattus norvegicus	56-65
20967881-0	2011	Astrocyte reactivity to unconjugated bilirubin requires TNF-alpha and IL-1beta receptor signaling pathways.	Bilirubin	37-46	interleukin 1 beta	Rattus norvegicus	70-78
20967881-2	2011	We have reported that tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta are produced by cultured neurons and mainly by glial cells exposed to unconjugated bilirubin (UCB).	Bilirubin	166-175	tumor necrosis factor	Rattus norvegicus	22-55
20967881-2	2011	We have reported that tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta are produced by cultured neurons and mainly by glial cells exposed to unconjugated bilirubin (UCB).	Bilirubin	166-175	interleukin 1 beta	Rattus norvegicus	60-82
21735820-2	2011	UDP-glucuronyltransferases, UGT, catalyse transformations of bilirubine, steroids and thyroid hormones, bile acids as well as exogenous compounds, including drugs, carcinogens, environmental pollutants and nutrient components.	Bilirubin	61-71	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	28-31
20881436-1	2011	BACKGROUND: The serum concentration of unbound bilirubin (UB), which is bilirubin not bound to albumin (Alb), is a better index than total bilirubin concentration (TB) for identifying infants at risk for developing bilirubin neurotoxicity.	Bilirubin	47-56	albumin	Homo sapiens	104-107
22216172-1	2011	We have previously reported that exposure of SH-SY5Y neuroblastoma cells to unconjugated bilirubin (UCB) resulted in a marked up-regulation of the mRNA encoding for the Na(+)-independent cystine:glutamate exchanger System X(c)(-) (SLC7A11 and SLC3A2 genes).	Bilirubin	89-98	solute carrier family 7 member 11	Homo sapiens	231-238
22216172-1	2011	We have previously reported that exposure of SH-SY5Y neuroblastoma cells to unconjugated bilirubin (UCB) resulted in a marked up-regulation of the mRNA encoding for the Na(+)-independent cystine:glutamate exchanger System X(c)(-) (SLC7A11 and SLC3A2 genes).	Bilirubin	89-98	solute carrier family 3 member 2	Homo sapiens	243-249
20615907-14	2011	Male PCK rats on sirolimus presented with increased concentrations of bile acids and bilirubin compared with controls (each P &lt; 0.05 at 12 weeks).	Bilirubin	85-94	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	5-8
21401295-3	2011	Intraperitoneal injection of 400 mg/kg D-GalN and 50 mug/kg LPS was able to induce hepatotoxicity in rats, as evidenced by significant increases in liver enzymes (ALT, AST) and raised bilirubin levels in plasma.	Bilirubin	184-193	galanin and GMAP prepropeptide	Rattus norvegicus	41-45
21401295-4	2011	Heme oxygenase-1 and nitric oxide synthase-2 gene expressions were significantly increased, along with levels of their products, bilirubin and nitrite.	Bilirubin	129-138	heme oxygenase 1	Rattus norvegicus	0-44
20643109-4	2010	Beneficial protective effects of HO-1 in inflammation are not only mediated via enzymatic degradation of proinflammatory free heme, but also via production of the anti-inflammatory compounds bilirubin and carbon monoxide.	Bilirubin	191-200	heme oxygenase 1	Homo sapiens	33-37
21351260-1	2010	UDP-glucuronosyltransferase 1A1 (UGT1A1) is an enzyme which catalyses not only the glucuronidation of tobacco smoke carcinogens like benzopyrene, but also of the endogenous substrate bilirubin.	Bilirubin	183-192	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	33-39
21351260-8	2010	In conclusion, the predicted high activity UGT1A1*1 polymorphism, which results in lower serum levels of the endogenous antioxidant bilirubin, was associated with an increased risk of head and neck cancer.	Bilirubin	132-141	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	43-49
29255399-4	2010	The activities of the marker enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and bilirubin were highest in rats treated with CCl4 alone.	Bilirubin	134-143	C-C motif chemokine ligand 4	Rattus norvegicus	178-182
20713168-4	2010	Heme oxygenase-1 (HO-1), an inducible enzyme, catalyzes the oxidative degradation of heme to free iron, carbon monoxide, and biliverdin, the latter being subsequently converted into bilirubin.	Bilirubin	182-191	heme oxygenase 1	Homo sapiens	0-16
20713168-4	2010	Heme oxygenase-1 (HO-1), an inducible enzyme, catalyzes the oxidative degradation of heme to free iron, carbon monoxide, and biliverdin, the latter being subsequently converted into bilirubin.	Bilirubin	182-191	heme oxygenase 1	Homo sapiens	18-22
20831901-4	2010	Levels of aspartate and alanine aminotransferases (AST and ALT) correlated with duration of pain (Pearson correlation, r = 0.633 and 0.622 respectively, P &lt; .001 for both); the correlation was not as strong for gamma-glutamyl transpeptidase (GGT) (r = 0.326, P = .046) and was not significant for alkaline phosphatase or bilirubin.	Bilirubin	324-333	solute carrier family 17 member 5	Homo sapiens	51-54
20704544-2	2010	BVR is the sole catalyst for the conversion of biliverdin-IXalpha the activity product of the stress-inducible HO-1 and the constitutive HO-2, to bilirubin-IXalpha.	Bilirubin	146-155	biliverdin reductase A	Homo sapiens	0-3
21135346-0	2010	Hour-specific bilirubin nomogram in infants with ABO incompatibility and direct Coombs-positive results.	Bilirubin	14-23	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	49-52
20704544-2	2010	BVR is the sole catalyst for the conversion of biliverdin-IXalpha the activity product of the stress-inducible HO-1 and the constitutive HO-2, to bilirubin-IXalpha.	Bilirubin	146-155	heme oxygenase 1	Homo sapiens	111-115
20704550-5	2010	The vasoprotection afforded by HO-1 is largely attributable to its end products: CO and the bile pigments, biliverdin and bilirubin.	Bilirubin	122-131	heme oxygenase 1	Homo sapiens	31-35
20704548-3	2010	HO-1 catalyzes the degradation of free cellular heme to iron, carbon monoxide (CO) and biliverdin which is eventually converted to bilirubin by biliverdin reductase.	Bilirubin	131-140	heme oxygenase 1	Homo sapiens	0-4
20937712-11	2010	Nitric oxide has been implicated in mechanisms of bilirubin toxicity elsewhere in the brain, and antagonism of nNOS by 7-nitroindazole protected hearing during bilirubin exposure.	Bilirubin	160-169	nitric oxide synthase 1	Rattus norvegicus	111-115
20818342-11	2010	Extensive perivenular CK7 positivity was significantly associated with both elevated bilirubin, as well as the presence of fibrosis.	Bilirubin	85-94	keratin 7	Homo sapiens	22-25
20238246-11	2010	AFP, bilirubin and age were found to be inter-related factors for HCC severity and survival.	Bilirubin	5-14	HCC	Homo sapiens	66-69
20837016-5	2010	RESULTS: By using the presence of bilirubin as a phenotype, variants rs6742078 (UGT1A1; P = .003), rs4149056 (SLCO1B1; P = .003), and rs4149000 (SLCO1A2; P = .015) were associated with gallstone composition.	Bilirubin	34-43	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	80-86
20837016-10	2010	CONCLUSIONS: The UGT1A1 Gilbert syndrome variant rs6742078 is associated with gallstone disease in men; further studies are required regarding the sex-specific physiology of bilirubin and bile acid metabolism.	Bilirubin	174-183	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	17-23
20668247-0	2010	Bilirubin glucuronidation revisited: proper assay conditions to estimate enzyme kinetics with recombinant UGT1A1.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	106-112
20881452-7	2010	Administration of bilirubin improved glucose control and enhanced glucose tolerance in diabetic recipients, and reduced the serum levels of inflammatory mediators including IL-1beta, TNF-alpha, soluble intercellular adhesion molecule 1, monocyte chemoattractant protein-1 and NO, and inhibited the infiltration of Kupffer cells into the islet grafts, and restored insulin-producing ability of transplanted islets.	Bilirubin	18-27	interleukin 1 beta	Rattus norvegicus	173-181
20881452-7	2010	Administration of bilirubin improved glucose control and enhanced glucose tolerance in diabetic recipients, and reduced the serum levels of inflammatory mediators including IL-1beta, TNF-alpha, soluble intercellular adhesion molecule 1, monocyte chemoattractant protein-1 and NO, and inhibited the infiltration of Kupffer cells into the islet grafts, and restored insulin-producing ability of transplanted islets.	Bilirubin	18-27	tumor necrosis factor	Rattus norvegicus	183-192
20881452-7	2010	Administration of bilirubin improved glucose control and enhanced glucose tolerance in diabetic recipients, and reduced the serum levels of inflammatory mediators including IL-1beta, TNF-alpha, soluble intercellular adhesion molecule 1, monocyte chemoattractant protein-1 and NO, and inhibited the infiltration of Kupffer cells into the islet grafts, and restored insulin-producing ability of transplanted islets.	Bilirubin	18-27	C-C motif chemokine ligand 2	Rattus norvegicus	237-271
21086566-11	2010	Additionally, plasma osteopontin was positively related to serum total bilirubin (r = 0.64, P &lt; 0.001).	Bilirubin	71-80	secreted phosphoprotein 1	Homo sapiens	21-32
21108708-11	2010	In the PELD era, ICU hospitalization, weight, and very high bilirubin levels were associated with poor survival.	Bilirubin	60-69	BSCL2 lipid droplet biogenesis associated, seipin	Homo sapiens	7-11
20668247-1	2010	Bilirubin, an end product of heme catabolism, is primarily eliminated via glucuronic acid conjugation by UGT1A1.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	105-111
20668247-2	2010	Impaired bilirubin conjugation, caused by inhibition of UGT1A1, can result in clinical consequences, including jaundice and kernicterus.	Bilirubin	9-18	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	56-62
20668247-3	2010	Thus, evaluation of the ability of new drug candidates to inhibit UGT1A1-catalyzed bilirubin glucuronidation in vitro has become common practice.	Bilirubin	83-92	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	66-72
20668247-10	2010	In conclusion, establishment of appropriate incubation conditions (i.e., very low protein concentrations and short incubation times) is necessary to properly characterize the kinetics of bilirubin glucuronidation in a recombinant UGT1A1 system.	Bilirubin	187-196	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	230-236
20679134-2	2010	Enzymatic studies with the purified 30-kDa form of HO-1 routinely use a coupled assay containing biliverdin reductase (BVR), which converts BV to bilirubin (BR).	Bilirubin	146-155	heme oxygenase 1	Homo sapiens	51-55
20679134-2	2010	Enzymatic studies with the purified 30-kDa form of HO-1 routinely use a coupled assay containing biliverdin reductase (BVR), which converts BV to bilirubin (BR).	Bilirubin	146-155	biliverdin reductase A	Homo sapiens	97-117
20679134-2	2010	Enzymatic studies with the purified 30-kDa form of HO-1 routinely use a coupled assay containing biliverdin reductase (BVR), which converts BV to bilirubin (BR).	Bilirubin	146-155	biliverdin reductase A	Homo sapiens	119-122
20801125-17	2010	When potential interferents (hemoglobin, triglycerides, and bilirubin) were added at two times the physiological concentrations, AMH concentrations were within +- 10% of the control.	Bilirubin	60-69	anti-Mullerian hormone	Homo sapiens	129-132
20709051-0	2010	The effect of UGT1A1 promoter polymorphism on bilirubin response to hydroxyurea therapy in hemoglobinopathies.	Bilirubin	46-55	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	14-20
20668235-7	2010	Blood levels of unconjugated bilirubin were significantly increased in mice treated with indinavir or anti-UGT1A1 (P = 0.002).	Bilirubin	29-38	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	107-113
20693308-9	2010	SUMMARY: Serum bilirubin has a protective effect on CVD and CVD-related diseases, and UGT1A1 is the major gene controlling serum bilirubin concentrations.	Bilirubin	129-138	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	86-92
20693308-7	2010	A conditional linkage study indicates that UGT1A1 is the major gene controlling serum bilirubin concentrations, and this finding has been confirmed in recent genomewide association studies.	Bilirubin	86-95	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	43-49
21068477-0	2010	Unconjugated bilirubin modulates nitric oxide production via iNOS regulation.	Bilirubin	13-22	nitric oxide synthase 2, inducible	Mus musculus	61-65
20860438-3	2010	d-GalN/LPS (300 mg/kg body weight/30 microg/kg body weight)-induced hepatic damage was manifested by a significant (p &lt;0.05) increase in the activities of marker enzymes (aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and gamma glutamyl transferase) and bilirubin level in serum while phospholipids significantly decreased.	Bilirubin	300-309	galanin and GMAP prepropeptide	Rattus norvegicus	2-6
20580034-4	2010	We focused on the role of HO-1 and its major metabolic product, bilirubin, on mechanisms of tumor necrosis factor-alpha-induced endothelial cell activation and protection by the catechin epigallocatechin gallate (EGCG).	Bilirubin	64-73	tumor necrosis factor	Homo sapiens	92-119
20547221-2	2010	A bilirubin-biliverdin cycling mechanism has been proposed to explain this remarkable effect whereby bilirubin reacts with oxyradicals specifically generating biliverdin, which is then reduced back to bilirubin by NADPH/biliverdin reductase.	Bilirubin	2-11	2,4-dienoyl-CoA reductase 1	Homo sapiens	214-219
20610401-6	2010	However, FLVCR has a narrow substrate range because unconjugated bilirubin, the primary breakdown product of heme, was not transported.	Bilirubin	65-74	FLVCR heme transporter 1	Homo sapiens	9-14
20061399-1	2010	Alterations in the hepatic conjugation of bilirubin due to uridyl-diphosphate-glucuronosyltransferase 1A1 (UGT1A1) polymorphisms have been proposed as risk factors to neonatal jaundice.	Bilirubin	42-51	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	59-105
20061399-1	2010	Alterations in the hepatic conjugation of bilirubin due to uridyl-diphosphate-glucuronosyltransferase 1A1 (UGT1A1) polymorphisms have been proposed as risk factors to neonatal jaundice.	Bilirubin	42-51	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	107-113
20639394-4	2010	In a conditional analysis adjusted for the top UGT1A1 variant (rs11891311), another variant in UGT1A1 (rs4148323, P = 1.22 x 10(-121)) remained significant; this suggests that in UGT1A1 at least two independent genetic variations influence the bilirubin levels in the Korean population.	Bilirubin	244-253	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	95-101
20639394-4	2010	In a conditional analysis adjusted for the top UGT1A1 variant (rs11891311), another variant in UGT1A1 (rs4148323, P = 1.22 x 10(-121)) remained significant; this suggests that in UGT1A1 at least two independent genetic variations influence the bilirubin levels in the Korean population.	Bilirubin	244-253	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	95-101
20546738-8	2010	RESULTS: In Gunn rats, bilirubin levels normalized 2 weeks after administration of mTTR.hUGT1A1.	Bilirubin	23-32	transthyretin	Mus musculus	83-87
20546738-8	2010	RESULTS: In Gunn rats, bilirubin levels normalized 2 weeks after administration of mTTR.hUGT1A1.	Bilirubin	23-32	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	88-95
20546738-10	2010	In contrast, in rats injected with mTTR-UGT1A1.142T, bilirubin levels normalized for up to 6 months and transduced cells were not eliminated.	Bilirubin	53-62	transthyretin	Mus musculus	35-39
20546738-10	2010	In contrast, in rats injected with mTTR-UGT1A1.142T, bilirubin levels normalized for up to 6 months and transduced cells were not eliminated.	Bilirubin	53-62	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	40-46
20547221-2	2010	A bilirubin-biliverdin cycling mechanism has been proposed to explain this remarkable effect whereby bilirubin reacts with oxyradicals specifically generating biliverdin, which is then reduced back to bilirubin by NADPH/biliverdin reductase.	Bilirubin	101-110	2,4-dienoyl-CoA reductase 1	Homo sapiens	214-219
20547221-2	2010	A bilirubin-biliverdin cycling mechanism has been proposed to explain this remarkable effect whereby bilirubin reacts with oxyradicals specifically generating biliverdin, which is then reduced back to bilirubin by NADPH/biliverdin reductase.	Bilirubin	101-110	2,4-dienoyl-CoA reductase 1	Homo sapiens	214-219
20689484-1	2010	OBJECTIVES: Heme oxygenase 1 (HO-1) is rapidly induced by stress, degrading pro-oxidant heme into carbon monoxide, bilirubin, and free iron (Fe).	Bilirubin	115-124	heme oxygenase 1	Homo sapiens	12-28
20689484-1	2010	OBJECTIVES: Heme oxygenase 1 (HO-1) is rapidly induced by stress, degrading pro-oxidant heme into carbon monoxide, bilirubin, and free iron (Fe).	Bilirubin	115-124	heme oxygenase 1	Homo sapiens	30-34
20689484-4	2010	METHODS: Changes in the HO-1 activity after AMI were analyzed by measuring serum levels of bilirubin and Fe.	Bilirubin	91-100	heme oxygenase 1	Homo sapiens	24-28
20689484-9	2010	Furthermore, the serum HO-1 protein level was elevated, and its change was significantly correlated with the change in bilirubin level (r = 0.82, P &lt; 0.005).	Bilirubin	119-128	heme oxygenase 1	Homo sapiens	23-27
20716749-0	2010	Association of bilirubin with cardiovascular outcomes: more hype than substance?	Bilirubin	15-24	FIC domain protein adenylyltransferase	Homo sapiens	60-64
21092520-3	2010	The uridine diphosphate-glucuronosyl transferase 1A1 (UGT 1A1) gene controls bilirubin conjugation by determining the structure of the enzyme glucuronosyltransferase, which is synthesized in the hepatocyte.	Bilirubin	77-86	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	4-52
21092520-3	2010	The uridine diphosphate-glucuronosyl transferase 1A1 (UGT 1A1) gene controls bilirubin conjugation by determining the structure of the enzyme glucuronosyltransferase, which is synthesized in the hepatocyte.	Bilirubin	77-86	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	54-61
21092521-2	2010	OATP 1B1 is an important polymorphism gene which transmembrane transports unconjugated bilirubin(UCB).	Bilirubin	87-96	solute carrier organic anion transporter family member 1B1	Homo sapiens	0-8
21092521-5	2010	Some studies have shown that OATP 1B1 mediates bilirubin uptake from blood into the liver, and the OATP 1B1 polymorphism is a likely mechanism explaining the differences of bilirubin level in peripheral blood.	Bilirubin	47-56	solute carrier organic anion transporter family member 1B1	Homo sapiens	29-37
21092521-5	2010	Some studies have shown that OATP 1B1 mediates bilirubin uptake from blood into the liver, and the OATP 1B1 polymorphism is a likely mechanism explaining the differences of bilirubin level in peripheral blood.	Bilirubin	173-182	solute carrier organic anion transporter family member 1B1	Homo sapiens	99-107
21092521-21	2010	Among the three OATP 1B1 A388G genotypes, the level of total serum bilirubin (TSB), direct bilirubin (DB) and unconjugated bilirubin (UCB) were significantly different.	Bilirubin	67-76	solute carrier organic anion transporter family member 1B1	Homo sapiens	16-24
21092521-21	2010	Among the three OATP 1B1 A388G genotypes, the level of total serum bilirubin (TSB), direct bilirubin (DB) and unconjugated bilirubin (UCB) were significantly different.	Bilirubin	91-100	solute carrier organic anion transporter family member 1B1	Homo sapiens	16-24
21092521-21	2010	Among the three OATP 1B1 A388G genotypes, the level of total serum bilirubin (TSB), direct bilirubin (DB) and unconjugated bilirubin (UCB) were significantly different.	Bilirubin	91-100	solute carrier organic anion transporter family member 1B1	Homo sapiens	16-24
21092521-25	2010	CONCLUSIONS: Our findings indicated that OATP 1B1 A388G polymorphism has a notable influence on the serum bilirubin level in neonatal hyperbilirubinemia patients.	Bilirubin	106-115	solute carrier organic anion transporter family member 1B1	Homo sapiens	41-49
20562445-2	2010	A major reason for the variability is a common promoter polymorphism, UGT1A1*28, which reduces the transcription of the enzyme that conjugates bilirubin, UDP-glucuronosyltransferase 1A1.	Bilirubin	143-152	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	70-76
20562445-2	2010	A major reason for the variability is a common promoter polymorphism, UGT1A1*28, which reduces the transcription of the enzyme that conjugates bilirubin, UDP-glucuronosyltransferase 1A1.	Bilirubin	143-152	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	154-185
20561511-0	2010	Protein kinase A and C signaling induces bilirubin potentiation of GABA/glycinergic synaptic transmission in rat ventral cochlear nucleus neurons.	Bilirubin	41-50	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	0-16
20561511-5	2010	Forskolin (PKA activator) and H-89 (PKA inhibitor) also individually increased mIPSCs frequency, with an additional increase induced by co-incubation with bilirubin and H-89.	Bilirubin	155-164	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	11-14
20561511-5	2010	Forskolin (PKA activator) and H-89 (PKA inhibitor) also individually increased mIPSCs frequency, with an additional increase induced by co-incubation with bilirubin and H-89.	Bilirubin	155-164	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	36-39
20561511-12	2010	Bilirubin facilitates transmitter release via presynaptic PKA activation, which might provide insight into the cellular mechanism underlying bilirubin-induced hearing dysfunction.	Bilirubin	0-9	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	58-61
20561511-12	2010	Bilirubin facilitates transmitter release via presynaptic PKA activation, which might provide insight into the cellular mechanism underlying bilirubin-induced hearing dysfunction.	Bilirubin	141-150	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	58-61
20588179-5	2010	Two weeks after onset of Ang II infusion, systolic blood pressure significantly increased from 134 +/- 4 to 198 +/- 7 mm Hg (P &lt; 0.05) in the Ang II group and from 128 +/- 8 to 209 +/- 9 mm Hg (P &lt; 0.05) in the Ang II + bilirubin group.	Bilirubin	226-235	angiotensinogen	Rattus norvegicus	25-31
20588179-7	2010	However, urinary protein excretion was significantly lower in the Ang II + bilirubin group (32.9 +/- 9.7 mg/d versus 81.4 +/- 22.8 mg/d, P &lt; 0.05).	Bilirubin	75-84	angiotensinogen	Rattus norvegicus	66-72
20588179-8	2010	The authors conclude that exogenous bilirubin exerts renoprotective effects in Ang II-dependent hypertension.	Bilirubin	36-45	angiotensinogen	Rattus norvegicus	79-85
20430037-0	2010	Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1-evidence for direct and indirect antioxidant actions of bilirubin.	Bilirubin	28-37	biliverdin reductase A	Homo sapiens	41-61
20462651-6	2010	There were inverse correlations between CD4+CD45RO+ telomere length and fibrosis stage (p&lt;0.001), portal tract inflammatory grade (p=0.035), prothrombin time (p&lt;0.001) and bilirubin (p=0.001).	Bilirubin	178-187	CD4 molecule	Homo sapiens	40-43
20082599-3	2010	Although ABCC2/Abcc2 transports a variety of amphiphilic anions that belong to different classes of molecules, such as endogenous compounds (e.g., bilirubin-glucuronides), drugs, toxic chemicals, nutraceuticals, and their conjugates, it displays a preference for phase II conjugates.	Bilirubin	147-156	ATP binding cassette subfamily C member 2	Homo sapiens	9-14
20082599-3	2010	Although ABCC2/Abcc2 transports a variety of amphiphilic anions that belong to different classes of molecules, such as endogenous compounds (e.g., bilirubin-glucuronides), drugs, toxic chemicals, nutraceuticals, and their conjugates, it displays a preference for phase II conjugates.	Bilirubin	147-156	ATP binding cassette subfamily C member 2	Homo sapiens	15-20
20639239-3	2010	This study was conducted to evaluate the prognostic role of serum bilirubin in disease progression and clinical outcome in patients with CSX.	Bilirubin	66-75	NK2 homeobox 5	Homo sapiens	137-140
20639239-12	2010	CONCLUSIONS: In patients with CSX, baseline serum bilirubin level was associated with long-term outcomes.	Bilirubin	50-59	NK2 homeobox 5	Homo sapiens	30-33
20639239-13	2010	Serum bilirubin could be a predictive and protective biomarker for disease progression and the development of cardiovascular events in CSX patients.	Bilirubin	6-15	NK2 homeobox 5	Homo sapiens	135-138
20430037-0	2010	Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1-evidence for direct and indirect antioxidant actions of bilirubin.	Bilirubin	28-37	heme oxygenase 1	Homo sapiens	108-124
20430037-0	2010	Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1-evidence for direct and indirect antioxidant actions of bilirubin.	Bilirubin	181-190	biliverdin reductase A	Homo sapiens	41-61
20430037-0	2010	Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1-evidence for direct and indirect antioxidant actions of bilirubin.	Bilirubin	181-190	heme oxygenase 1	Homo sapiens	108-124
20430037-2	2010	HO-1-derived bilirubin is an efficient scavenger of reactive oxygen and nitrogen species (RONS).	Bilirubin	13-22	heme oxygenase 1	Homo sapiens	0-4
20430037-3	2010	It remains to determine whether conversion of biliverdin to bilirubin is an essential step for HO-1-conferred protection of endothelial cells.	Bilirubin	60-69	heme oxygenase 1	Homo sapiens	95-99
20430037-7	2010	HO-1- and BVR-silenced cells have increased levels of oxidative stress and bilirubin but not biliverdin increased expression of the protective protein GTP-cyclohydrolase.	Bilirubin	75-84	heme oxygenase 1	Homo sapiens	0-4
20430037-7	2010	HO-1- and BVR-silenced cells have increased levels of oxidative stress and bilirubin but not biliverdin increased expression of the protective protein GTP-cyclohydrolase.	Bilirubin	75-84	biliverdin reductase A	Homo sapiens	10-13
20430037-8	2010	Moreover, protection by hemin-induced HO-1 expression or biliverdin-triggered bilirubin formation was impaired upon silencing of the HO-1 or BVR gene, respectively.	Bilirubin	78-87	heme oxygenase 1	Homo sapiens	133-137
20430037-8	2010	Moreover, protection by hemin-induced HO-1 expression or biliverdin-triggered bilirubin formation was impaired upon silencing of the HO-1 or BVR gene, respectively.	Bilirubin	78-87	biliverdin reductase A	Homo sapiens	141-144
20435641-3	2010	To elucidate these molecular mechanisms, we simulated and analysed the glucuronidation of wild-type UGT1A1 and six UGT1A1 mutants, with bilirubin as the substrate.	Bilirubin	136-145	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	100-106
20155807-10	2010	Furthermore, 6-OHDA-induced toxicity was blocked by bilirubin and carbon monoxide, products of the HO-1-catalyzed degradation of heme.	Bilirubin	52-61	heme oxygenase 1	Homo sapiens	99-103
20207085-5	2010	Recent work has linked PNJ to a specific enzyme polymorphism, a variation of the UGT1A1 gene, in the glucoronidation pathway which is essential for bilirubin metabolism and is strongly correlated with ethnic origin.	Bilirubin	148-157	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	81-87
20592649-5	2010	Linear regression analysis showed a significant positive impact of bilirubin (r2 = 0.230) on bias with further increases of r2 to 0.261, 0.286, and 0.294 with the stepwise addition of creatinine, hematocrit, and gamma-glutamyl transpeptidase, respectively.	Bilirubin	67-76	inactive glutathione hydrolase 2	Homo sapiens	212-241
21033244-3	2010	Two cohorts of patients with both low AFP and bilirubin levels were identified, who had serum GGTP levels with an increasing trend with increasing AFP levels.	Bilirubin	46-55	alpha fetoprotein	Homo sapiens	147-150
20518085-1	2010	Heme oxygenase-1 (HO-1) system catabolizes heme into three products: carbon monoxide, biliverdin/bilirubin and free iron.	Bilirubin	97-106	heme oxygenase 1	Homo sapiens	0-16
20306336-9	2010	We speculate that HO-1 gene delivery to the liver is beneficial in SCD mice by degrading pro-oxidative heme, releasing anti-inflammatory heme degradation products CO and biliverdin/bilirubin into circulation, activating cytoprotective pathways and inhibiting vascular stasis at sites distal to transgene expression.	Bilirubin	181-190	heme oxygenase 1	Mus musculus	18-22
20518085-1	2010	Heme oxygenase-1 (HO-1) system catabolizes heme into three products: carbon monoxide, biliverdin/bilirubin and free iron.	Bilirubin	97-106	heme oxygenase 1	Homo sapiens	18-22
20215562-4	2010	Here, we present a homology model of the complete monomeric human UGT1A1, the enzyme that catalyzes bilirubin glucuronidation.	Bilirubin	100-109	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	66-72
20362027-3	2010	D-GalN rats exhibited an increased hepato and nephro toxicity marker activities aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma glutamyl transpeptidase and total bilirubin level while urea, uric acid and creatinine and lipid profile.	Bilirubin	199-208	galanin and GMAP prepropeptide	Rattus norvegicus	2-6
20400908-2	2010	Here, preincubation with unconjugated bilirubin, a physiological antioxidant, resulted in increased viability and function of hepatocytes (as determined by trypan blue exclusion, mitochondrial succinate dehydrogenases activity, urea synthesis, and cytochrome P450 1A/2) compared with cells incubated without the pigment.	Bilirubin	38-47	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	248-268
20129611-2	2010	Plasma gamma-glutamyltransferase (GGT) activity is linked to bilirubin level in hepatic disease and elevated GGT is equally associated with hepatic steatosis, a frequent feature of metabolic syndrome (MS).	Bilirubin	61-70	gamma-glutamyltransferase light chain family member 3	Homo sapiens	7-32
20129611-2	2010	Plasma gamma-glutamyltransferase (GGT) activity is linked to bilirubin level in hepatic disease and elevated GGT is equally associated with hepatic steatosis, a frequent feature of metabolic syndrome (MS).	Bilirubin	61-70	gamma-glutamyltransferase light chain family member 3	Homo sapiens	34-37
20129611-3	2010	In order to assess the potential relationship between GGT activity and bilirubin levels in subjects exhibiting features of the metabolic syndrome, we determined circulating bilirubin levels and GGT activity in a cohort of dyslipidemic patients.	Bilirubin	71-80	gamma-glutamyltransferase light chain family member 3	Homo sapiens	54-57
20129611-8	2010	CONCLUSION: Elevation in systemic GGT activity, which is characterized by extended generation of ROS, together with potentially deficient bilirubin-mediated antioxidative capacity of plasma, may therefore constitute key components of the systemic oxidative stress typical of metabolic syndrome.	Bilirubin	138-147	gamma-glutamyltransferase light chain family member 3	Homo sapiens	34-37
20370320-0	2010	Contributions of the Ah receptor to bilirubin homeostasis and its antioxidative and atheroprotective functions.	Bilirubin	36-45	aryl hydrocarbon receptor	Homo sapiens	21-32
20370320-1	2010	Abstract The homeostasis and atheroprotective function of bilirubin could be an appealing model to investigate one of the many physiologic functions of the human aryl hydrocarbon receptor (AhR).	Bilirubin	58-67	aryl hydrocarbon receptor	Homo sapiens	162-187
20370320-1	2010	Abstract The homeostasis and atheroprotective function of bilirubin could be an appealing model to investigate one of the many physiologic functions of the human aryl hydrocarbon receptor (AhR).	Bilirubin	58-67	aryl hydrocarbon receptor	Homo sapiens	189-192
20370320-2	2010	Several clinical and epidemiological studies have been carried out on key enzymes generating and eliminating bilirubin (heme oxygenase-1 and UDP-glucuronosyltransferase UGT1A1, respectively) and their regulation by the AhR.	Bilirubin	109-118	heme oxygenase 1	Homo sapiens	120-136
20370320-2	2010	Several clinical and epidemiological studies have been carried out on key enzymes generating and eliminating bilirubin (heme oxygenase-1 and UDP-glucuronosyltransferase UGT1A1, respectively) and their regulation by the AhR.	Bilirubin	109-118	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	169-175
20370320-2	2010	Several clinical and epidemiological studies have been carried out on key enzymes generating and eliminating bilirubin (heme oxygenase-1 and UDP-glucuronosyltransferase UGT1A1, respectively) and their regulation by the AhR.	Bilirubin	109-118	aryl hydrocarbon receptor	Homo sapiens	219-222
20370320-5	2010	The strong antioxidant and activator of AhR bilirubin is generated in vascular endothelial cells, smooth muscles and macrophages.	Bilirubin	44-53	aryl hydrocarbon receptor	Homo sapiens	40-43
20370320-7	2010	In conclusion, the atheroprotective functions of bilirubin might not only provide models to study physiologic functions of the human AhR but also provide opportunities to improve prevention and treatment of a major life-threatening disease.	Bilirubin	49-58	aryl hydrocarbon receptor	Homo sapiens	133-136
20303781-8	2010	TNFSF9 mRNA significantly correlated with serum TBIL, gamma-GT, and IL-18 (P&lt;0.05, P&lt;0.01, P&lt;0.01).	Bilirubin	48-52	TNF superfamily member 9	Homo sapiens	0-6
20495302-8	2010	Serum bilirubin level was inversely related to insulin resistance using the homeostasis model assessment (HOMA-IR), serum insulin, and C-reactive protein (CRP) levels in multiple linear regression analyses.	Bilirubin	6-15	insulin	Homo sapiens	47-54
20127499-1	2010	Heme oxygenase-1 (HO-1) catalyses the rate-limiting step of heme degradation to biliverdin, which is in turn reduced to bilirubin, CO and free iron.	Bilirubin	120-129	heme oxygenase 1	Rattus norvegicus	0-16
20127499-1	2010	Heme oxygenase-1 (HO-1) catalyses the rate-limiting step of heme degradation to biliverdin, which is in turn reduced to bilirubin, CO and free iron.	Bilirubin	120-129	heme oxygenase 1	Rattus norvegicus	18-22
20022574-2	2010	In particular, polymorphisms across three genes involved in bilirubin production and metabolism [glucose-6-phosphate dehydrogenase (G6PD), uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1), and solute carrier organic anion transporter polypeptide 1B1 (SLCO1B1)] may interact with each other and/or environmental contributors to produce significant hyperbilirubinemia.	Bilirubin	60-69	glucose-6-phosphate dehydrogenase	Homo sapiens	97-130
20022574-2	2010	In particular, polymorphisms across three genes involved in bilirubin production and metabolism [glucose-6-phosphate dehydrogenase (G6PD), uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1), and solute carrier organic anion transporter polypeptide 1B1 (SLCO1B1)] may interact with each other and/or environmental contributors to produce significant hyperbilirubinemia.	Bilirubin	60-69	glucose-6-phosphate dehydrogenase	Homo sapiens	132-136
20022574-2	2010	In particular, polymorphisms across three genes involved in bilirubin production and metabolism [glucose-6-phosphate dehydrogenase (G6PD), uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1), and solute carrier organic anion transporter polypeptide 1B1 (SLCO1B1)] may interact with each other and/or environmental contributors to produce significant hyperbilirubinemia.	Bilirubin	60-69	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	139-187
20022574-2	2010	In particular, polymorphisms across three genes involved in bilirubin production and metabolism [glucose-6-phosphate dehydrogenase (G6PD), uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1), and solute carrier organic anion transporter polypeptide 1B1 (SLCO1B1)] may interact with each other and/or environmental contributors to produce significant hyperbilirubinemia.	Bilirubin	60-69	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	189-195
20495302-8	2010	Serum bilirubin level was inversely related to insulin resistance using the homeostasis model assessment (HOMA-IR), serum insulin, and C-reactive protein (CRP) levels in multiple linear regression analyses.	Bilirubin	6-15	insulin	Homo sapiens	122-129
20495302-8	2010	Serum bilirubin level was inversely related to insulin resistance using the homeostasis model assessment (HOMA-IR), serum insulin, and C-reactive protein (CRP) levels in multiple linear regression analyses.	Bilirubin	6-15	C-reactive protein	Homo sapiens	135-153
20495302-8	2010	Serum bilirubin level was inversely related to insulin resistance using the homeostasis model assessment (HOMA-IR), serum insulin, and C-reactive protein (CRP) levels in multiple linear regression analyses.	Bilirubin	6-15	C-reactive protein	Homo sapiens	155-158
20056895-6	2010	Importantly, patients with an elevation of total bilirubin level (&gt;2 mg/dl) had a strong increase of glycans modified with alpha1-6 fucose.	Bilirubin	49-58	adrenoceptor alpha 1D	Homo sapiens	126-134
20631420-3	2010	As HO-1 can produce endogenous anti-oxidant and anti-inflammatory moieties such as bilirubin and carbon monoxide (CO), these findings suggest a novel mechanism of action for aminosalicylates, acting as anti-colitic agents through the up-regulation of HO-1 enzyme expression and activity.	Bilirubin	83-92	heme oxygenase 1	Homo sapiens	3-7
19890094-5	2010	The protective effect was specific for HO-1 because it was reproduced on administration of the end products of HO-1 activity, carbon monoxide, and bilirubin, and prevented by the pharmacologic inhibition of HO-1 using tin mesoporphyrin IX.	Bilirubin	147-156	heme oxygenase 1	Homo sapiens	39-43
20083320-0	2010	Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women.	Bilirubin	30-39	C-reactive protein	Homo sapiens	62-80
20083320-1	2010	AIM: The aim of this study was to examine the association of serum bilirubin, an endogenous antioxidant, with serum high sensitivity C-reactive protein (hs-CRP) level, HbA(1c), and the prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women (n=12,400).	Bilirubin	67-76	C-reactive protein	Homo sapiens	133-151
20511137-3	2010	Numerous variants have been found in UGT1A1 , the main conjugating enzyme of bilirubin and drugs such as the anticancer drug irinotecan.	Bilirubin	77-86	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	37-43
20197307-2	2010	The constitutive androstane receptor (CAR) is an orphan nuclear receptor that has been shown to participate in the activation of the uridine diphosphate-5"-glucuronosyltransferase 1A1 (UGT1A1) gene, which plays an important role in bilirubin clearance.	Bilirubin	232-241	nuclear receptor subfamily 1 group I member 3	Homo sapiens	4-36
20044810-13	2010	Lower platelet count and higher total bilirubin at 2 years were significantly associated with an increased risk of developing new varices in patients with PSC.	Bilirubin	38-47	PSC	Homo sapiens	155-158
20338478-5	2010	RESULTS: Both tumor cells and macrophages displayed a coherent picture of iNOS induction at transcriptional/translational levels and NO/nitrite production, whereas macrophages showed also co-induction of the inducible heme oxygenase-1, which is associated with carbon monoxide (CO) and bilirubin production.	Bilirubin	286-295	heme oxygenase 1	Mus musculus	218-234
20197307-2	2010	The constitutive androstane receptor (CAR) is an orphan nuclear receptor that has been shown to participate in the activation of the uridine diphosphate-5"-glucuronosyltransferase 1A1 (UGT1A1) gene, which plays an important role in bilirubin clearance.	Bilirubin	232-241	nuclear receptor subfamily 1 group I member 3	Homo sapiens	38-41
20197307-2	2010	The constitutive androstane receptor (CAR) is an orphan nuclear receptor that has been shown to participate in the activation of the uridine diphosphate-5"-glucuronosyltransferase 1A1 (UGT1A1) gene, which plays an important role in bilirubin clearance.	Bilirubin	232-241	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	133-183
20197307-2	2010	The constitutive androstane receptor (CAR) is an orphan nuclear receptor that has been shown to participate in the activation of the uridine diphosphate-5"-glucuronosyltransferase 1A1 (UGT1A1) gene, which plays an important role in bilirubin clearance.	Bilirubin	232-241	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	185-191
20197307-7	2010	These data suggest that OSM might play a role in bilirubin metabolism via the CAR-UGT1A1 pathway.	Bilirubin	49-58	nuclear receptor subfamily 1 group I member 3	Homo sapiens	78-81
20197307-7	2010	These data suggest that OSM might play a role in bilirubin metabolism via the CAR-UGT1A1 pathway.	Bilirubin	49-58	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	82-88
20194756-1	2010	High levels of unconjugated bilirubin (UCB) in newborn children is associated with a reduction in hepatic UDP glucuronosyltransferase (UGT) 1A1 activity that can lead to CNS toxicity, brain damage, and even death.	Bilirubin	28-37	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	106-143
19953640-3	2010	Crigler-Najjar syndrome is another rare disorder of bilirubin metabolism caused by mutation in the gene coding the enzyme UGT1A1.	Bilirubin	52-61	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	122-128
20186750-0	2010	A proteomic approach to the bilirubin-induced toxicity in neuronal cells reveals a protective function of DJ-1 protein.	Bilirubin	28-37	Parkinsonism associated deglycase	Homo sapiens	106-110
20057336-1	2010	The uridine diphosphoglucuronate-glucuronosyltransferase 1A1 (UGT1A1) gene encodes the enzyme responsible for bilirubin glucuronidation.	Bilirubin	110-119	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	4-60
20057336-1	2010	The uridine diphosphoglucuronate-glucuronosyltransferase 1A1 (UGT1A1) gene encodes the enzyme responsible for bilirubin glucuronidation.	Bilirubin	110-119	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	62-68
20194756-5	2010	Adult Tg(UGT1(A1*28))Ugt1(-/-) mice expressed elevated levels of total bilirubin (TB) compared with Tg(UGT1(A1*1))Ugt1(-/-) mice, confirming that the promoter polymorphism associated with the UGT1A1*28 allele contributes to hyperbilirubinemia in mice.	Bilirubin	71-80	UDP glucuronosyltransferase 1 family, polypeptide A2	Mus musculus	9-13
20194756-5	2010	Adult Tg(UGT1(A1*28))Ugt1(-/-) mice expressed elevated levels of total bilirubin (TB) compared with Tg(UGT1(A1*1))Ugt1(-/-) mice, confirming that the promoter polymorphism associated with the UGT1A1*28 allele contributes to hyperbilirubinemia in mice.	Bilirubin	71-80	UDP glucuronosyltransferase 1 family, polypeptide A2	Mus musculus	21-25
20194756-8	2010	In approximately 10% of the humanized UGT1 mice, peak TB levels culminated in seizures followed by death.	Bilirubin	54-56	UDP glucuronosyltransferase 1 family, polypeptide A2	Mus musculus	38-42
23675170-2	2010	ADA1*2 allele has been found associated with higher bilirubin levels in newborns and with a protective action against bronchial asthma.	Bilirubin	52-61	transcriptional adaptor 1	Homo sapiens	0-4
19931474-0	2010	Hereditary spherocytosis and the (TA)nTAA polymorphism of UGT1A1 gene promoter region--a comparison of the bilirubin plasmatic levels in the different clinical forms.	Bilirubin	107-116	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	58-64
20020468-6	2010	Furthermore, downstream products of HO-1, bilirubin, carbon monoxide, and iron, are involved in the inhibitory action of HO-1.	Bilirubin	42-51	heme oxygenase 1	Homo sapiens	36-40
20020468-6	2010	Furthermore, downstream products of HO-1, bilirubin, carbon monoxide, and iron, are involved in the inhibitory action of HO-1.	Bilirubin	42-51	heme oxygenase 1	Homo sapiens	121-125
20379040-10	2010	Although the correlation index for this inverse association has been weak, both are independently associated with a higher prevalence of coronary artery disease, total bilirubin &lt;or= 0.56 mg/dL (OR: 10.04; IC: 3.48-28.90; P &lt; 0.001), and ultrasensitive C reactive protein &gt; 3 mg/L (OR: 1.17; IC: 1.04-1.33; P = 0.009).	Bilirubin	168-177	C-reactive protein	Homo sapiens	259-277
23675170-9	2010	In infants treated by phototherapy, the maximum bilirubin level attained during the first few days of life positively correlated with the ADA1*2 allele dose (p=0.001).	Bilirubin	48-57	transcriptional adaptor 1	Homo sapiens	138-142
23675170-11	2010	CONCLUSIONS: These observations support our hypothesis that ADA1*2 allele through an increase of bilirubin level in the neonatal period protects infants from oxidative stress and favours Th2 Th1 switching thus preventing allergic manifestations in later periods of life.	Bilirubin	97-106	transcriptional adaptor 1	Homo sapiens	60-64
19831498-7	2010	In addition and similar to observations with CYPs, UGTs may be responsible for homeostatic control of AhR ligands, such as bilirubin, a fruitful area to be studied in the future.	Bilirubin	123-132	aryl hydrocarbon receptor	Homo sapiens	102-105
20333281-4	2010	Heme oxygenase-1 (HO-1) is catalyzing enzyme in heme breakdown process to release iron, carbon monoxide, and biliverdin/bilirubin, and may influence iron supply to the P. falciparum parasites.	Bilirubin	120-129	heme oxygenase 1	Homo sapiens	0-16
20333281-4	2010	Heme oxygenase-1 (HO-1) is catalyzing enzyme in heme breakdown process to release iron, carbon monoxide, and biliverdin/bilirubin, and may influence iron supply to the P. falciparum parasites.	Bilirubin	120-129	heme oxygenase 1	Homo sapiens	18-22
20549981-0	2010	[Preparation of bovine serum albumin immobilized adsorbent for specific adsorption of bilirubin].	Bilirubin	86-95	albumin	Homo sapiens	23-36
20549981-3	2010	In this study, a bilirubin specific adsorbent was prepared by covalently immobilizing bovine serum albumin (BSA) onto macroporous poly (glycidyl methacrylate-co-trimethylolpropane trimethacrylate) microspheres.	Bilirubin	17-26	albumin	Homo sapiens	93-106
20145519-11	2010	N-(1-naphtyl)ethylendiamine dihydrochloride (5 microM), a specific iNOS inhibitor, largely blunted the production of RNS, prevented the increase of alanine aminotransferase and bilirubin, restored liver regeneration, and improved survival of FPG.	Bilirubin	177-186	nitric oxide synthase 2	Rattus norvegicus	67-71
19452123-8	2010	The transhepatic SLPI gradient correlated with postoperative liver enzymes (ALT R = -0.648, P = 0.043; ALP R = -0.661, P = 0.038; bilirubin R = -0.821, P = 0.004; GGT R = -0.648, P = 0.043).	Bilirubin	130-139	secretory leukocyte peptidase inhibitor	Homo sapiens	17-21
20128033-6	2010	In patients with chronic liver disease, there was a positive relationship between thymosin beta4 levels and albumin, choline esterase, and platelet (P &lt; 0.001), and negative relationship with alanine aminotransferase (P = 0.020), aspartate aminotransferase, total bilirubin, international normalized ratio of prothrombin time, and Child-Pugh and MELD scores (P &lt; 0.001).	Bilirubin	267-276	thymosin beta 4 X-linked	Homo sapiens	82-96
19831728-5	2010	In the present review, we will discuss i) how bilirubin reduces its circulating levels by activating AhR in the liver; ii) how bile acids modulate their hepatic glucuronidation via PXR- and FXR-dependent processes in enterohepatic tissues; and iii) how androgens inhibit their cellular metabolism in prostate cancer cells through an AR-dependent mechanism.	Bilirubin	46-55	aryl hydrocarbon receptor	Homo sapiens	101-104
19831728-5	2010	In the present review, we will discuss i) how bilirubin reduces its circulating levels by activating AhR in the liver; ii) how bile acids modulate their hepatic glucuronidation via PXR- and FXR-dependent processes in enterohepatic tissues; and iii) how androgens inhibit their cellular metabolism in prostate cancer cells through an AR-dependent mechanism.	Bilirubin	46-55	nuclear receptor subfamily 1 group H member 4	Homo sapiens	190-193
19857043-2	2010	The UGT enzymes are located in the endoplasmic reticulum of almost all tissues, where they catalyze the inactivation of several endogenous and exogenous molecules, including bilirubin, sex steroids, numerous prescribed drugs, and environmental toxins.	Bilirubin	174-183	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	4-7
20356510-7	2010	The level of TNFalpha in peripheral was correlated with those of ALT (P = 0.005), AST (P = 0.002), total bilirubin (TBil) (P = 0.001), direct bilirubin (DBil) (P = 0.002), and mayo risk score (MRS) (P = 0.020).	Bilirubin	105-114	tumor necrosis factor	Homo sapiens	13-21
19925812-1	2010	Heme oxygenase-1 (HO-1) is up-regulated in response to oxidative stress and catalyzes the degradation of pro-oxidant heme to carbon monoxide (CO), iron and bilirubin.	Bilirubin	156-165	heme oxygenase 1	Homo sapiens	0-16
19925812-1	2010	Heme oxygenase-1 (HO-1) is up-regulated in response to oxidative stress and catalyzes the degradation of pro-oxidant heme to carbon monoxide (CO), iron and bilirubin.	Bilirubin	156-165	heme oxygenase 1	Homo sapiens	18-22
19925812-9	2010	The downstream product bilirubin increased GDNF expression through ERK and PI3K-Akt pathways, and also enhanced NFkappaB (p65 and p50) nuclear translocation in glia-enriched cultures.	Bilirubin	23-32	glial cell derived neurotrophic factor	Homo sapiens	43-47
19925812-9	2010	The downstream product bilirubin increased GDNF expression through ERK and PI3K-Akt pathways, and also enhanced NFkappaB (p65 and p50) nuclear translocation in glia-enriched cultures.	Bilirubin	23-32	mitogen-activated protein kinase 1	Homo sapiens	67-70
19925812-9	2010	The downstream product bilirubin increased GDNF expression through ERK and PI3K-Akt pathways, and also enhanced NFkappaB (p65 and p50) nuclear translocation in glia-enriched cultures.	Bilirubin	23-32	nuclear factor kappa B subunit 1	Homo sapiens	112-120
19925812-9	2010	The downstream product bilirubin increased GDNF expression through ERK and PI3K-Akt pathways, and also enhanced NFkappaB (p65 and p50) nuclear translocation in glia-enriched cultures.	Bilirubin	23-32	RELA proto-oncogene, NF-kB subunit	Homo sapiens	122-125
19925812-9	2010	The downstream product bilirubin increased GDNF expression through ERK and PI3K-Akt pathways, and also enhanced NFkappaB (p65 and p50) nuclear translocation in glia-enriched cultures.	Bilirubin	23-32	nuclear factor kappa B subunit 1	Homo sapiens	130-133
19925812-10	2010	In addition, bilirubin also enhanced BDNF expression through similar pathway in cortical neuron-enriched cultures.	Bilirubin	13-22	brain derived neurotrophic factor	Homo sapiens	37-41
19925812-13	2010	These results indicate that the downstream products of HO-1, i.e. bilirubin and CO, modulate BDNF and GDNF expression in neuron and astrocyte.	Bilirubin	66-75	heme oxygenase 1	Homo sapiens	55-59
19925812-13	2010	These results indicate that the downstream products of HO-1, i.e. bilirubin and CO, modulate BDNF and GDNF expression in neuron and astrocyte.	Bilirubin	66-75	brain derived neurotrophic factor	Homo sapiens	93-97
19925812-13	2010	These results indicate that the downstream products of HO-1, i.e. bilirubin and CO, modulate BDNF and GDNF expression in neuron and astrocyte.	Bilirubin	66-75	glial cell derived neurotrophic factor	Homo sapiens	102-106
19932091-1	2010	BACKGROUND: The basis of Gilbert"s syndrome is a 70% reduction in bilirubin glucuronidation which, in the Caucasian population, is the result of a homozygous TA insertion into the promoter region of the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene (UGT1A128 allele).	Bilirubin	66-75	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	203-234
19932091-1	2010	BACKGROUND: The basis of Gilbert"s syndrome is a 70% reduction in bilirubin glucuronidation which, in the Caucasian population, is the result of a homozygous TA insertion into the promoter region of the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene (UGT1A128 allele).	Bilirubin	66-75	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	236-242
19932091-1	2010	BACKGROUND: The basis of Gilbert"s syndrome is a 70% reduction in bilirubin glucuronidation which, in the Caucasian population, is the result of a homozygous TA insertion into the promoter region of the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene (UGT1A128 allele).	Bilirubin	66-75	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	236-241
19833210-2	2010	From a series of biochemical studies, it has been found that L-PGDS has an ability to bind a variety of lipophilic ligands such as biliverdin, bilirubin and retinoids in vitro.	Bilirubin	143-152	prostaglandin D2 synthase	Homo sapiens	61-67
20356510-7	2010	The level of TNFalpha in peripheral was correlated with those of ALT (P = 0.005), AST (P = 0.002), total bilirubin (TBil) (P = 0.001), direct bilirubin (DBil) (P = 0.002), and mayo risk score (MRS) (P = 0.020).	Bilirubin	116-120	tumor necrosis factor	Homo sapiens	13-21
20356510-7	2010	The level of TNFalpha in peripheral was correlated with those of ALT (P = 0.005), AST (P = 0.002), total bilirubin (TBil) (P = 0.001), direct bilirubin (DBil) (P = 0.002), and mayo risk score (MRS) (P = 0.020).	Bilirubin	142-151	tumor necrosis factor	Homo sapiens	13-21
20021735-3	2010	Bilirubin treatment of recipients improved function of islet allografts by suppressing expressions of proinflammatory and proapoptotic genes in those islets and by increasing Foxp3(+) T regulatory (Treg) cells at the site of transplanted islets at various days after transplantation.	Bilirubin	0-9	forkhead box P3	Mus musculus	175-180
19955297-8	2010	DISCUSSION: Atazanavir is an inhibitor of the bilirubin-conjugating enzyme UGT1A1 and has been frequently linked to the occurrence of hyperbilirubinemia without complications.	Bilirubin	46-55	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	75-81
19326137-0	2010	The effect of oxytocin infusion and misoprostol on neonatal bilirubin levels.	Bilirubin	60-69	oxytocin/neurophysin I prepropeptide	Homo sapiens	14-22
19326137-1	2010	PURPOSE: To investigate the association of neonatal bilirubin levels with oxytocin and misoprostol use for labour induction.	Bilirubin	52-61	oxytocin/neurophysin I prepropeptide	Homo sapiens	74-82
19326137-5	2010	RESULTS: The levels of bilirubin in the oxytocin group were significantly higher than those in the misoprostol group on day 1 [4.42 +- 0.27 mg/dl versus 3.55 +- 0.28 mg/dl (P = 0.035)] while they were higher also on day 4 but was not significantly so [7.47 +- 0.63 mg/dl versus 6.86 +- 0.65 mg/dl (P = 0.525)].	Bilirubin	23-32	oxytocin/neurophysin I prepropeptide	Homo sapiens	40-48
19566819-6	2010	Unlike MRP1, MRP2 functions in the extrusion of endogenous organic anions, such as bilirubin glucuronide and certain anticancer agents.	Bilirubin	83-92	ATP binding cassette subfamily C member 1	Homo sapiens	7-11
19566819-6	2010	Unlike MRP1, MRP2 functions in the extrusion of endogenous organic anions, such as bilirubin glucuronide and certain anticancer agents.	Bilirubin	83-92	ATP binding cassette subfamily C member 2	Homo sapiens	13-17
20663207-15	2010	Treatment with APC was associated with an increase in serum levels of both total and conjugated bilirubin.	Bilirubin	96-105	APC regulator of WNT signaling pathway	Homo sapiens	15-18
20663207-18	2010	Instead we found an increase in serum bilirubin in the APC group compared to the placebo group in patients with SAP.	Bilirubin	38-47	APC regulator of WNT signaling pathway	Homo sapiens	55-58
20948202-2	2010	A major cause of elevated plasma bilirubin is the common UGT1A1*28 promoter polymorphism in the gene of the bilirubin-conjugating enzyme UDP-glucuronosyltransferase 1A1, which reduces transcription by 70%.	Bilirubin	33-42	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	57-63
20948202-2	2010	A major cause of elevated plasma bilirubin is the common UGT1A1*28 promoter polymorphism in the gene of the bilirubin-conjugating enzyme UDP-glucuronosyltransferase 1A1, which reduces transcription by 70%.	Bilirubin	33-42	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	137-168
20948202-2	2010	A major cause of elevated plasma bilirubin is the common UGT1A1*28 promoter polymorphism in the gene of the bilirubin-conjugating enzyme UDP-glucuronosyltransferase 1A1, which reduces transcription by 70%.	Bilirubin	108-117	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	57-63
20948202-2	2010	A major cause of elevated plasma bilirubin is the common UGT1A1*28 promoter polymorphism in the gene of the bilirubin-conjugating enzyme UDP-glucuronosyltransferase 1A1, which reduces transcription by 70%.	Bilirubin	108-117	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	137-168
20948202-8	2010	The UGT1A1*28 polymorphism (allele frequency 30%) showed a strong gene-dose relationship with bilirubin levels both among cases and referents, but was not associated with risk for stroke.	Bilirubin	94-103	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	4-10
20184791-5	2010	Over the past decade, compelling evidence has revealed that the induction of HO-1 represents an important defensive mechanism against further oxidative injury in tissues and cells following various insults; this occurs by virtue of the anti-inflammatory and antioxidant capacities of CO, biliverdin, and the subsequent metabolite of biliverdin, bilirubin.	Bilirubin	345-354	heme oxygenase 1	Homo sapiens	77-81
20021735-6	2010	In addition, bilirubin treatment promoted de novo generation of Treg cells in Rag1(-/-) recipients.	Bilirubin	13-22	recombination activating 1	Mus musculus	78-82
19833099-7	2009	Further linear correlation analysis demonstrated significant correlations between expression of TLR3 signaling components (TLR3 and IFN-beta) and disease severity markers (prothrombin activity and total bilirubin) for individual ACHBLF patients.	Bilirubin	203-212	toll like receptor 3	Homo sapiens	96-100
19222504-7	2010	Grafts with hepatic IL-8 release exhibited subsequently higher alkaline phosphatase [319 (213-405) IU/L vs. 175 (149-208) IU/L, p = 0.006] and bilirubin [101 (44-139) micromol/L vs. 30 (23-72) micromol/L, p = 0.029] levels after transplantation.	Bilirubin	143-152	C-X-C motif chemokine ligand 8	Homo sapiens	20-24
19830808-7	2010	In addition to bilirubin, we also determined their activity toward eight other UGT1A1 substrates.	Bilirubin	15-24	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	79-85
20358470-4	2010	We also explored the association between the UGT1A1*28 polymorphism and serum bilirubin concentrations and DNA damage and repair measures.	Bilirubin	78-87	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	45-51
20666718-4	2010	Both endogenous compounds (glutathione, ubiquinol, urate, bilirubin) and enzymes (superoxide dismutase, catalase, glutathione peroxidase) are engaged in the detoxification of ROS.	Bilirubin	58-67	catalase	Homo sapiens	104-112
20645920-8	2010	Abcc3-difficient mice have normal bile salt transport, however they have decreased blood bilirubin glucuronide levels.	Bilirubin	89-98	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	0-5
19573997-7	2010	The lethality of influenza is also reduced in mice pretreated with adenovirus carrying the gene for heme oxygenase-1; this benefit may be mediated, at least in part, by the ability of bilirubin to inhibit NADPH oxidase.	Bilirubin	184-193	heme oxygenase 1	Mus musculus	100-116
19747074-6	2009	Homeostatic feedback loops might not only include CYP1A1 but also Phase II enzymes such as UGT1A1 which controls the antioxidant AhR ligand bilirubin.	Bilirubin	140-149	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	50-56
20062892-9	2010	RESULTS: Compared with the control group (A), the serum bilirubin and amylase in the model group increased significantly after 7 days of treatment, and fibrotic proliferation of pancreatic tissues were found after 35 days; the expression of PTCH-1, SMO, and SHH in the pancreatic tissue increased significantly in the model group.	Bilirubin	56-65	patched 1	Rattus norvegicus	241-247
19277692-0	2009	The effect of oxytocin infusion and misoprostol on neonatal bilirubin levels.	Bilirubin	60-69	oxytocin/neurophysin I prepropeptide	Homo sapiens	14-22
19277692-1	2009	PURPOSE: To investigate the association of neonatal bilirubin levels with oxytocin and misoprostol use for labour induction.	Bilirubin	52-61	oxytocin/neurophysin I prepropeptide	Homo sapiens	74-82
19277692-5	2009	RESULTS: The levels of bilirubin in the oxytocin group were significantly higher than those in the misoprostol group on day 1 [4.42 +/- 0.27 vs. 3.55 +/- 0.28 mg/dl (P = 0.035)] while they were higher also on day 4 but not significantly so [7.47 +/- 0.63 vs. 6.86 +/- 0.65 mg/dl (P = 0.525)].	Bilirubin	23-32	oxytocin/neurophysin I prepropeptide	Homo sapiens	40-48
19747074-6	2009	Homeostatic feedback loops might not only include CYP1A1 but also Phase II enzymes such as UGT1A1 which controls the antioxidant AhR ligand bilirubin.	Bilirubin	140-149	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	91-97
19952426-6	2009	The altered mRNA and protein levels of constitutive androstane receptor (CAR) and peroxisome proliferator-activated receptor alpha (PPARalpha) in the nucleus were consistent with the changes in the plasma concentrations of total and conjugated bilirubin and fatty acid, respectively.	Bilirubin	244-253	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	39-71
19747074-6	2009	Homeostatic feedback loops might not only include CYP1A1 but also Phase II enzymes such as UGT1A1 which controls the antioxidant AhR ligand bilirubin.	Bilirubin	140-149	aryl hydrocarbon receptor	Homo sapiens	129-132
19952426-6	2009	The altered mRNA and protein levels of constitutive androstane receptor (CAR) and peroxisome proliferator-activated receptor alpha (PPARalpha) in the nucleus were consistent with the changes in the plasma concentrations of total and conjugated bilirubin and fatty acid, respectively.	Bilirubin	244-253	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	73-76
20071295-3	2009	It was supposed that patients with the UGT1A1*28 polymorphism would have a greater prevalence of elevated pretreatment serum bilirubin levels and higher toxicity.	Bilirubin	125-134	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	39-45
19952426-6	2009	The altered mRNA and protein levels of constitutive androstane receptor (CAR) and peroxisome proliferator-activated receptor alpha (PPARalpha) in the nucleus were consistent with the changes in the plasma concentrations of total and conjugated bilirubin and fatty acid, respectively.	Bilirubin	244-253	peroxisome proliferator activated receptor alpha	Rattus norvegicus	82-130
19952426-6	2009	The altered mRNA and protein levels of constitutive androstane receptor (CAR) and peroxisome proliferator-activated receptor alpha (PPARalpha) in the nucleus were consistent with the changes in the plasma concentrations of total and conjugated bilirubin and fatty acid, respectively.	Bilirubin	244-253	peroxisome proliferator activated receptor alpha	Rattus norvegicus	132-141
19952426-8	2009	These results suggested that the increase in the levels of bilirubin and fatty acid on the BDL groups altered the mRNA and protein levels of CAR and PPARalpha, respectively in the nucleus, and this in turn altered the mRNA expression of metabolic enzymes and transporters as a hepatoprotective mechanism.	Bilirubin	59-68	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	141-144
19952426-8	2009	These results suggested that the increase in the levels of bilirubin and fatty acid on the BDL groups altered the mRNA and protein levels of CAR and PPARalpha, respectively in the nucleus, and this in turn altered the mRNA expression of metabolic enzymes and transporters as a hepatoprotective mechanism.	Bilirubin	59-68	peroxisome proliferator activated receptor alpha	Rattus norvegicus	149-158
20608094-4	2009	Expressions of biopyrrins and heme oxygenase-1 (HO-1), a stress-responsive bilirubin-producing enzyme, in heart, aorta, kidney, liver and lung were immunostained with autopsied specimens.	Bilirubin	75-84	heme oxygenase 1	Homo sapiens	30-46
20608094-4	2009	Expressions of biopyrrins and heme oxygenase-1 (HO-1), a stress-responsive bilirubin-producing enzyme, in heart, aorta, kidney, liver and lung were immunostained with autopsied specimens.	Bilirubin	75-84	heme oxygenase 1	Homo sapiens	48-52
20608094-12	2009	Induction of anti-oxidative enzyme HO-1 seemed to be involved in the activation of bilirubin/biopyrrin pathway.	Bilirubin	83-92	heme oxygenase 1	Homo sapiens	35-39
19672597-8	2009	CONCLUSIONS: The isolated increase in serum bilirubin levels in our patient was probably due to sorafenib-induced UGT1A1 inhibition that manifested itself due both to the patient having one UGT1A1*28 allele and the presence of underlying liver disease.	Bilirubin	44-53	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	114-120
19672597-8	2009	CONCLUSIONS: The isolated increase in serum bilirubin levels in our patient was probably due to sorafenib-induced UGT1A1 inhibition that manifested itself due both to the patient having one UGT1A1*28 allele and the presence of underlying liver disease.	Bilirubin	44-53	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	190-196
19732748-6	2009	Moreover, the increase in serum bilirubin levels was attenuated in the Keap1-kd mice.	Bilirubin	32-41	kelch-like ECH-associated protein 1	Mus musculus	71-76
19948621-2	2009	Variants in the UGT1A1 gene contribute to increased bilirubin levels, and bilirubin can act as an antioxidant.	Bilirubin	52-61	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	16-22
19948621-2	2009	Variants in the UGT1A1 gene contribute to increased bilirubin levels, and bilirubin can act as an antioxidant.	Bilirubin	74-83	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	16-22
19560444-2	2009	While the linear tetrapyrrole bilirubin has been shown to be a substrate for the organic anion transporting polypeptide 1B1 (OATP1B1), similar studies have not been conducted for the cyclic tetrapyrroles (porphyrins).	Bilirubin	30-39	solute carrier organic anion transporter family member 1B1	Homo sapiens	81-123
19759334-9	2009	We conclude that decreased levels of cellular bilirubin increase ANG II-mediated superoxide production and sodium transport; however, increases in bilirubin are not necessary for HO-1 induction to attenuate ANG II-mediated superoxide production.	Bilirubin	46-55	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	65-71
19759334-1	2009	Induction of heme oxygenase-1 (HO-1) in the renal medulla increases carbon monoxide and bilirubin production and decreases ANG II-mediated superoxide production.	Bilirubin	88-97	heme oxygenase 1	Mus musculus	13-29
19759334-1	2009	Induction of heme oxygenase-1 (HO-1) in the renal medulla increases carbon monoxide and bilirubin production and decreases ANG II-mediated superoxide production.	Bilirubin	88-97	heme oxygenase 1	Mus musculus	31-35
19759334-2	2009	The goal of this study was to determine the importance of increases in bilirubin to the antioxidant effects of HO-1 induction in cultured mouse thick ascending loop of Henle (TALH) and inner medullary collecting duct (IMCD3) cells.	Bilirubin	71-80	heme oxygenase 1	Mus musculus	111-115
19560444-2	2009	While the linear tetrapyrrole bilirubin has been shown to be a substrate for the organic anion transporting polypeptide 1B1 (OATP1B1), similar studies have not been conducted for the cyclic tetrapyrroles (porphyrins).	Bilirubin	30-39	solute carrier organic anion transporter family member 1B1	Homo sapiens	125-132
19783517-5	2009	CCl4 induced a significant rise in serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), total bilirubin and gamma glutamate transpeptidase (GGTP).	Bilirubin	165-174	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
19710077-11	2009	Indirect bilirubin increased 1.6- to 2.8-fold more in subjects with UGT1A1 *28/*28 versus *1/*28 or *1/*1.	Bilirubin	9-18	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	68-74
19710077-15	2009	The wild-type ABCB1 CGC haplotype was associated with slower CL/F and the UGT1A1 *28 genotype was associated with increased bilirubin.	Bilirubin	124-133	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	74-80
19542024-4	2009	Coinciding with maximal HO-1 induction in the injured vessel, plasma concentrations of bilirubin and the numbers of circulating progenitor cells were elevated.	Bilirubin	87-96	heme oxygenase 1	Mus musculus	24-28
19732760-0	2009	Haplotypes in the UGT1A1 gene and their role as genetic determinants of bilirubin concentration in healthy German volunteers.	Bilirubin	72-81	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	18-24
19732760-1	2009	BACKGROUND: Genetic variations of UDP-glucuronyltransferase 1A1 (UGT1A1) influence the concentration of serum bilirubin.	Bilirubin	110-119	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	34-63
19732760-1	2009	BACKGROUND: Genetic variations of UDP-glucuronyltransferase 1A1 (UGT1A1) influence the concentration of serum bilirubin.	Bilirubin	110-119	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	65-71
19732760-2	2009	We investigated the association of four common polymorphisms including UGT1A1-53(TA)(n), and common haplotypes of the UGT1A1 gene with bilirubin levels in 218 Caucasian volunteers.	Bilirubin	135-144	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	118-124
19732760-9	2009	Male sex, UGT1A1-53(TA)(6/7) and the c.-3279GG variant were significantly associated with higher bilirubin concentrations.	Bilirubin	97-106	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	10-16
19732760-10	2009	CONCLUSIONS: Two UGT1A1 promoter polymorphisms (-53(TA)(6/7) and c.-3279T&gt;G) and a common haplotype of the UGT1A1 gene are associated with serum bilirubin concentrations in Caucasians.	Bilirubin	148-157	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	17-23
19732760-10	2009	CONCLUSIONS: Two UGT1A1 promoter polymorphisms (-53(TA)(6/7) and c.-3279T&gt;G) and a common haplotype of the UGT1A1 gene are associated with serum bilirubin concentrations in Caucasians.	Bilirubin	148-157	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	110-116
19877201-9	2009	A20-treated mice had significantly lower bilirubin and aminotransferase levels, decreased hemorrhagic necrosis and steatosis, and increased hepatocyte proliferation.	Bilirubin	41-50	tumor necrosis factor, alpha-induced protein 3	Mus musculus	0-3
19690164-1	2009	In mammalian cells, heme is degraded by heme oxygenase to biliverdin, which is then reduced to bilirubin by biliverdin reductase (BVR).	Bilirubin	95-104	biliverdin reductase A	Homo sapiens	108-128
19690164-1	2009	In mammalian cells, heme is degraded by heme oxygenase to biliverdin, which is then reduced to bilirubin by biliverdin reductase (BVR).	Bilirubin	95-104	biliverdin reductase A	Homo sapiens	130-133
19690164-3	2009	A presently popular explanation for the antioxidant function of bilirubin is a redox cycle in which bilirubin is oxidized to biliverdin and then recycled by BVR.	Bilirubin	64-73	biliverdin reductase A	Homo sapiens	157-160
19690164-3	2009	A presently popular explanation for the antioxidant function of bilirubin is a redox cycle in which bilirubin is oxidized to biliverdin and then recycled by BVR.	Bilirubin	100-109	biliverdin reductase A	Homo sapiens	157-160
19625608-7	2009	Finally, treatment of endothelial cells with HOCl stimulated mitochondrial dysfunction, caspase-3 activation, and cell death that was potentiated by the HO inhibitor, tin protoporphyrin-IX, or by the knockdown of HO-1, and reversed by the exogenous administration of biliverdin, bilirubin, or CO.	Bilirubin	279-288	heme oxygenase 1	Homo sapiens	213-217
19676108-8	2009	In contrast, bcl-x(flox/flox) mcl-1(flox/+) AlbCre, bcl-x(flox/+) mcl-1(flox/flox) AlbCre, and bcl-x(flox/flox) mcl-1(flox/flox) AlbCre mice displayed a decreased number of hepatocytes and a reduced volume of the liver on day 18.5 of embryogenesis and rapidly died within 1 day after birth, developing hepatic failure evidenced by increased levels of blood ammonia and bilirubin.	Bilirubin	369-378	BCL2-like 1	Mus musculus	13-18
19389676-0	2009	Conditional linkage and genome-wide association studies identify UGT1A1 as a major gene for anti-atherogenic serum bilirubin levels--the Framingham Heart Study.	Bilirubin	115-124	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	65-71
23960714-6	2009	CCl4 produced a significant increase in levels of serum glutamate pyruvate transaminase (GPT), serum glutamate oxaloacetate transaminase (GOT), Alkaline Phosphatase (ALP) and total bilirubin.	Bilirubin	181-190	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
19688601-1	2009	Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are transcription factors that control the expression of a broad array of genes involved not only in transcellular transport and biotransformation of many drugs, other xenochemicals, and endogenous substances, such as bile acid, bilirubin, and certain vitamins, but also in various physiological/pathophysiological processes such as lipid metabolism, glucose homeostasis, and inflammation.	Bilirubin	298-307	nuclear receptor subfamily 1 group I member 2	Homo sapiens	0-19
19688601-1	2009	Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are transcription factors that control the expression of a broad array of genes involved not only in transcellular transport and biotransformation of many drugs, other xenochemicals, and endogenous substances, such as bile acid, bilirubin, and certain vitamins, but also in various physiological/pathophysiological processes such as lipid metabolism, glucose homeostasis, and inflammation.	Bilirubin	298-307	nuclear receptor subfamily 1 group I member 2	Homo sapiens	21-24
19688601-1	2009	Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are transcription factors that control the expression of a broad array of genes involved not only in transcellular transport and biotransformation of many drugs, other xenochemicals, and endogenous substances, such as bile acid, bilirubin, and certain vitamins, but also in various physiological/pathophysiological processes such as lipid metabolism, glucose homeostasis, and inflammation.	Bilirubin	298-307	nuclear receptor subfamily 1 group I member 3	Homo sapiens	30-62
19688601-1	2009	Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are transcription factors that control the expression of a broad array of genes involved not only in transcellular transport and biotransformation of many drugs, other xenochemicals, and endogenous substances, such as bile acid, bilirubin, and certain vitamins, but also in various physiological/pathophysiological processes such as lipid metabolism, glucose homeostasis, and inflammation.	Bilirubin	298-307	nuclear receptor subfamily 1 group I member 3	Homo sapiens	64-67
19571206-0	2009	Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice.	Bilirubin	14-23	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	86-92
19571206-3	2009	This hypothesis was tested by treating mice with Indinavir, a drug that competes with bilirubin for metabolism by UDP-glucuronosyltransferase 1A1 (UGT1A1).	Bilirubin	86-95	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	114-145
19571206-3	2009	This hypothesis was tested by treating mice with Indinavir, a drug that competes with bilirubin for metabolism by UDP-glucuronosyltransferase 1A1 (UGT1A1).	Bilirubin	86-95	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	147-153
19571206-5	2009	Next, we determined the effect of Indinavir-induced changes in plasma bilirubin on the development of ANG II-dependent hypertension.	Bilirubin	70-79	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	102-108
19571206-9	2009	resulted in a twofold increase in plasma bilirubin levels and also attenuated the development of ANG II-dependent hypertension.	Bilirubin	41-50	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	97-103
19296952-4	2009	RESULTS: An inverse correlation was found between serum bilirubin concentration and log(CAC+1) (r=-0.361, P&lt;0.0001).	Bilirubin	56-65	transmembrane protein 54	Homo sapiens	88-93
19389676-10	2009	CONCLUSIONS: Our studies suggest that UGT1A1 may be the major gene with strong effects on bilirubin levels and the TA-repeat polymorphism might be the key polymorphism within the gene controlling bilirubin levels.	Bilirubin	196-205	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	38-44
19497955-7	2009	The mRNA and protein levels of the BA uptake transporter Ntcp were unchanged after PHx, whereas the canalicular Bsep protein increased twofold at 48 h. The basolateral efflux transporter Mrp3 was induced at the mRNA (2.6-fold) and protein (3.1-fold) levels after PHx, which may contribute to elevated plasma BA and bilirubin levels.	Bilirubin	315-324	ATP-binding cassette, sub-family B (MDR/TAP), member 11	Mus musculus	112-116
19497955-7	2009	The mRNA and protein levels of the BA uptake transporter Ntcp were unchanged after PHx, whereas the canalicular Bsep protein increased twofold at 48 h. The basolateral efflux transporter Mrp3 was induced at the mRNA (2.6-fold) and protein (3.1-fold) levels after PHx, which may contribute to elevated plasma BA and bilirubin levels.	Bilirubin	315-324	prolactin family 2, subfamily c, member 4	Mus musculus	187-191
19296952-7	2009	Both age and SBP were also positively associated with CAC score &gt; or =400, but the odds ratio for CAC score &gt; or =400 was greater for every 1 micromol/L increment in serum bilirubin concentration than for every 1-year increment in age and 1-mmHg increment in SBP.	Bilirubin	178-187	selenium binding protein 1	Homo sapiens	13-16
19296952-7	2009	Both age and SBP were also positively associated with CAC score &gt; or =400, but the odds ratio for CAC score &gt; or =400 was greater for every 1 micromol/L increment in serum bilirubin concentration than for every 1-year increment in age and 1-mmHg increment in SBP.	Bilirubin	178-187	selenium binding protein 1	Homo sapiens	265-268
19389676-10	2009	CONCLUSIONS: Our studies suggest that UGT1A1 may be the major gene with strong effects on bilirubin levels and the TA-repeat polymorphism might be the key polymorphism within the gene controlling bilirubin levels.	Bilirubin	90-99	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	38-44
19482841-6	2009	The effects of clinical factors and variants of the UGT1A1 gene on serum bilirubin levels were determined.	Bilirubin	73-82	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	52-58
19755821-4	2009	Similar to SN-38, bilirubin is excreted into bile after being glucuronidated by UGT1A1.	Bilirubin	18-27	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	80-86
19639209-3	2009	Of the GST super-family, the alpha class GSTs have commonly been described as one of the most versatile class, since it is responsible for detoxification of compounds such as bilirubin, bile acids and penicillin, thyroid and steroid hormones, allowing its solubilization and storage in the liver.	Bilirubin	175-184	glutathione S-transferase alpha 1	Homo sapiens	41-45
19776696-8	2009	Serum total bilirubin, alkaline phosphatase (ALP) and LPO were significantly (p &lt;0.05) elevated in subjects with PSA &gt;11 ng/ml.	Bilirubin	12-21	kallikrein related peptidase 3	Homo sapiens	116-119
19776696-9	2009	More specifically, total bilirubin, ALP and LPO levels were elevated by 75%, 66% and 107% in subjects with PSA at 11-20 ng/ml, and by 167%, 105%, 98% in subjects with PSA &gt; or = 20 ng/ml, respectively.	Bilirubin	25-34	kallikrein related peptidase 3	Homo sapiens	107-110
19776696-9	2009	More specifically, total bilirubin, ALP and LPO levels were elevated by 75%, 66% and 107% in subjects with PSA at 11-20 ng/ml, and by 167%, 105%, 98% in subjects with PSA &gt; or = 20 ng/ml, respectively.	Bilirubin	25-34	kallikrein related peptidase 3	Homo sapiens	167-170
19700139-2	2009	Besides harboring binding sites for NF-kappaB and AP-1, heme oxygenase (HO-1) generates cytoprotective products, including bilirubin and ferritin.	Bilirubin	123-132	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	50-54
19486253-1	2009	BACKGROUND AND AIMS: The gene product of the uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) is crucial to bilirubin metabolism.	Bilirubin	117-126	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	45-93
19486253-1	2009	BACKGROUND AND AIMS: The gene product of the uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) is crucial to bilirubin metabolism.	Bilirubin	117-126	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	95-101
19509285-1	2009	Biliverdin reductase A (BVR) catalyzes the reduction of biliverdin (BV) to bilirubin (BR) in all cells.	Bilirubin	75-84	biliverdin reductase A	Homo sapiens	24-27
21103282-8	2009	Thus, patients with PBC with serum bilirubin levels rising suddenly should undergo screening for associated hemolysis.	Bilirubin	35-44	dihydrolipoamide S-acetyltransferase	Homo sapiens	20-23
19523446-0	2009	Bilirubin inhibits the TNFalpha-related induction of three endothelial adhesion molecules.	Bilirubin	0-9	tumor necrosis factor	Mus musculus	23-31
19646271-0	2009	Targeted suppression of heme oxygenase-1 by small interference RNAs inhibits the production of bilirubin in neonatal rat with hyperbilirubinemia.	Bilirubin	95-104	heme oxygenase 1	Rattus norvegicus	24-40
19646271-3	2009	In the present study, we investigated whether suppression of rat HO-1 (rHO-1) expression by small interference RNAs (siRNAs) reduces bilirubin levels in hyperbilirubinemic rats.	Bilirubin	133-142	heme oxygenase 1	Rattus norvegicus	65-69
19646271-3	2009	In the present study, we investigated whether suppression of rat HO-1 (rHO-1) expression by small interference RNAs (siRNAs) reduces bilirubin levels in hyperbilirubinemic rats.	Bilirubin	133-142	heme oxygenase 1	Rattus norvegicus	71-76
19646271-8	2009	Systemic treatment of siRNA targeting rHO-1 reduced hepatic HO-1 expression and decreased the serum bilirubin levels in a time- and dose-dependent manner, and siRNA decreased the indirect bilirubin levels more effectively than Sn-protoporphyrin (SnPP), an HO-1 inhibitor.	Bilirubin	100-109	heme oxygenase 1	Rattus norvegicus	38-43
19646271-8	2009	Systemic treatment of siRNA targeting rHO-1 reduced hepatic HO-1 expression and decreased the serum bilirubin levels in a time- and dose-dependent manner, and siRNA decreased the indirect bilirubin levels more effectively than Sn-protoporphyrin (SnPP), an HO-1 inhibitor.	Bilirubin	100-109	heme oxygenase 1	Rattus norvegicus	39-43
19646271-8	2009	Systemic treatment of siRNA targeting rHO-1 reduced hepatic HO-1 expression and decreased the serum bilirubin levels in a time- and dose-dependent manner, and siRNA decreased the indirect bilirubin levels more effectively than Sn-protoporphyrin (SnPP), an HO-1 inhibitor.	Bilirubin	188-197	heme oxygenase 1	Rattus norvegicus	38-43
20141617-3	2009	The complexation of BR with saturating concentrations of human serum albumin (HSA, 2.5 microM) did not further increase nitric oxide release from GSNO and SNOC.	Bilirubin	20-22	albumin	Rattus norvegicus	63-84
19556236-1	2009	Heme oxygenase-1 (HO-1), a stress-inducible enzyme anchored in the endoplasmic reticulum (ER) by a single transmembrane segment (TMS) located at the C terminus, interacts with NADPH cytochrome P450 reductase and biliverdin reductase to catalyze heme degradation to biliverdin and its metabolite, bilirubin.	Bilirubin	296-305	heme oxygenase 1	Homo sapiens	0-16
19556236-1	2009	Heme oxygenase-1 (HO-1), a stress-inducible enzyme anchored in the endoplasmic reticulum (ER) by a single transmembrane segment (TMS) located at the C terminus, interacts with NADPH cytochrome P450 reductase and biliverdin reductase to catalyze heme degradation to biliverdin and its metabolite, bilirubin.	Bilirubin	296-305	heme oxygenase 1	Homo sapiens	18-22
20103840-1	2009	We have recently demonstrated that unconjugated bilirubin (UCB) limits the overexpression of adhesion molecules and inhibits the PMN endothelial adhesion induced by the pro-inflammatory cytokine TNFalpha.	Bilirubin	48-57	tumor necrosis factor	Homo sapiens	195-203
19387926-8	2009	There was also a correlation between serum total bilirubin and serum BMP7 levels (r=0.57, p&lt;0.001).	Bilirubin	49-58	bone morphogenetic protein 7	Homo sapiens	69-73
19788065-6	2009	The results suggest that ErB binds to a site in the vicinity of BR binding site on BSA.	Bilirubin	64-66	estrogen receptor 2	Bos taurus	25-28
19509285-4	2009	The enzymatic conversion of BV to BR on the surface by BVR initiates a signaling cascade through tyrosine phosphorylation of BVR on the cytoplasmic tail.	Bilirubin	34-36	biliverdin reductase A	Homo sapiens	55-58
19509285-4	2009	The enzymatic conversion of BV to BR on the surface by BVR initiates a signaling cascade through tyrosine phosphorylation of BVR on the cytoplasmic tail.	Bilirubin	34-36	biliverdin reductase A	Homo sapiens	125-128
19617811-7	2009	The milk concentrations of EGF were significantly correlated with neonatal bilirubin and blood EGF concentrations.	Bilirubin	75-84	epidermal growth factor	Homo sapiens	27-30
19617811-9	2009	Although the exact mechanisms of the hyperbilirubinemic action of EGF are not completely known, the inhibition of gastric motility, increased absorption, and activation of bilirubin transport have been suggested as possible mechanisms.	Bilirubin	42-51	epidermal growth factor	Homo sapiens	66-69
19702533-1	2009	The heme oxygenase/biliverdin reductase (HO/BVR) axis catalyzes the degradation of heme, but this system and its by-products, carbon monoxide (CO) and bilirubin, have also been shown to exert cytoprotective effects by activating pro-survival pathways and scavenging free radicals.	Bilirubin	151-160	biliverdin reductase A	Homo sapiens	41-47
19414484-3	2009	Meta-analysis showed strong replication for a genetic influence on serum bilirubin levels of the UGT1A1 locus (P &lt; 5 x 10(-324)) and a 12p12.2 locus.	Bilirubin	73-82	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	97-103
19414484-4	2009	The peak signal in the 12p12.2 region was a non-synonymous SNP in SLCO1B1 (rs4149056, P = 6.7 x 10(-13)), which gives rise to a valine to alanine amino acid change leading to reduced activity for a hepatic transporter with known affinity for bilirubin.	Bilirubin	242-251	solute carrier organic anion transporter family member 1B1	Homo sapiens	66-73
19414484-6	2009	The top variants in UGT1A1 and SLCO1B1 explain approximately 18.0 and approximately 1.0% of the variation in total serum bilirubin levels, respectively.	Bilirubin	121-130	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	20-26
19414484-6	2009	The top variants in UGT1A1 and SLCO1B1 explain approximately 18.0 and approximately 1.0% of the variation in total serum bilirubin levels, respectively.	Bilirubin	121-130	solute carrier organic anion transporter family member 1B1	Homo sapiens	31-38
19414484-8	2009	In one of the largest genetic studies of bilirubin to date (n = 9464), we confirm the substantial genetic influence of UGT1A1 variants, consistent with past linkage and association studies, and additionally provide strong evidence of a role for allelic variation in SLCO1B1.	Bilirubin	41-50	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	119-125
19414484-9	2009	Given the involvement of bilirubin in a number of physiological and disease processes, and the roles for UGT1A1 and SLCO1B1 in drug metabolism, these genetic findings have potential clinical importance.	Bilirubin	25-34	solute carrier organic anion transporter family member 1B1	Homo sapiens	116-123
19414484-10	2009	In analyses for association with gallbladder disease or gallstones, top bilirubin SNPs in UGT1A1 and SLCO1B1 were not associated.	Bilirubin	72-81	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	90-96
19419973-0	2009	Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.	Bilirubin	57-66	solute carrier organic anion transporter family member 1B3	Homo sapiens	23-30
19419973-5	2009	In addition to the two known loci previously involved in the regulation of bilirubin levels, UGT1A1 (P = 6.2 x 10(-62)) and G6PD (P = 2.5 x 10(-8)), we observed a strong association on chromosome 12 within the SLCO1B3 gene (P = 3.9 x 10(-9)).	Bilirubin	75-84	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	93-99
19419973-5	2009	In addition to the two known loci previously involved in the regulation of bilirubin levels, UGT1A1 (P = 6.2 x 10(-62)) and G6PD (P = 2.5 x 10(-8)), we observed a strong association on chromosome 12 within the SLCO1B3 gene (P = 3.9 x 10(-9)).	Bilirubin	75-84	solute carrier organic anion transporter family member 1B3	Homo sapiens	210-217
19372226-8	2009	Incubations with recombinant human UDP-glucuronosyltransferases (UGTs) and inhibition by the UGT1A4 and UGT1A1 substrates/inhibitors imipramine and bilirubin suggested that UGT1A4 is the major UGT isozyme catalyzing the N-glucuronidation of motesanib, with a minor contribution from UGT1A1.	Bilirubin	148-157	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	104-110
19702533-4	2009	However, upregulation of the HO/BVR axis is not always beneficial for cells: the heme depletion and accumulation of CO and bilirubin it causes are potentially toxic.	Bilirubin	123-132	biliverdin reductase A	Homo sapiens	29-35
19457088-7	2009	Heme-derived free ferrous iron, CO, and biliverdin/bilirubin are biologically active substances that have been shown to either ameliorate or exacerbate neural injury contingent upon specific disease models employed, the intensity and duration of HO-1 expression and the nature of the prevailing redox microenvironment.	Bilirubin	51-60	heme oxygenase 1	Homo sapiens	246-250
19457084-3	2009	Heme oxygenase-1 (HO-1), an enzyme that converts heme to free iron, carbon monoxide (CO) and biliverdin (bilirubin precursor) is expressed in response to various stressors.	Bilirubin	105-114	heme oxygenase 1	Homo sapiens	0-16
19486575-13	2009	In comparison to normal bilirubin level, the patient with bilirubin &gt;3mg/dl had high frequency of raised ALT 87.5% vs. 45% (p&lt;.0001), thrombocytopenia 91.6% vs. 65% (p&lt;.01), anemia 70.8% vs. 25% (p&lt;.05) and renal impairment 50% vs. 20% (p&gt;.05).	Bilirubin	58-67	glutamic--pyruvic transaminase	Homo sapiens	108-111
19457084-3	2009	Heme oxygenase-1 (HO-1), an enzyme that converts heme to free iron, carbon monoxide (CO) and biliverdin (bilirubin precursor) is expressed in response to various stressors.	Bilirubin	105-114	heme oxygenase 1	Homo sapiens	18-22
19063990-0	2009	Heme oxygenase-1 induction prevents neuronal damage triggered during mitochondrial inhibition: role of CO and bilirubin.	Bilirubin	110-119	heme oxygenase 1	Homo sapiens	0-16
19150444-0	2009	Unconjugated bilirubin inhibits C1 esterase activity.	Bilirubin	13-22	complement C1s	Homo sapiens	32-43
19150444-1	2009	OBJECTIVE: To evaluate if unconjugated bilirubin (UB) inhibits C1 esterase activity.	Bilirubin	39-48	complement C1s	Homo sapiens	63-74
19545710-13	2009	Intraportal insulin administration may significantly downregulate POD 7 total bilirubin, aspartate aminotransferase, and alanine aminotransferase levels (P &lt; .05).	Bilirubin	78-87	insulin	Homo sapiens	12-19
19343046-2	2009	On analysis, we observed a strong association between five SNPs within the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) gene and serum total bilirubin levels (minimum P-value in Mann-Whitney test=1.82 x 10(10)).	Bilirubin	153-162	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	75-122
19343046-2	2009	On analysis, we observed a strong association between five SNPs within the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) gene and serum total bilirubin levels (minimum P-value in Mann-Whitney test=1.82 x 10(10)).	Bilirubin	153-162	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	124-130
19343046-3	2009	UGT1A1 catalyzes the conjugation of bilirubin with glucuronic acid, thus enhancing bilirubin elimination.	Bilirubin	36-45	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
19343046-3	2009	UGT1A1 catalyzes the conjugation of bilirubin with glucuronic acid, thus enhancing bilirubin elimination.	Bilirubin	83-92	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
19343046-7	2009	Results of linear multiple regression analysis on serum total bilirubin levels followed by analysis of variance showed that at least 13% of the variance in serum total bilirubin levels could be explained by three haplotype-tagging SNPs in the UGT1A1 gene.	Bilirubin	168-177	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	243-249
19343046-7	2009	Results of linear multiple regression analysis on serum total bilirubin levels followed by analysis of variance showed that at least 13% of the variance in serum total bilirubin levels could be explained by three haplotype-tagging SNPs in the UGT1A1 gene.	Bilirubin	62-71	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	243-249
19301178-5	2009	Blood samples were taken and the activity of HO-1 inhibition was measured by the determination of bilirubin accumulation after bile duct ligation.	Bilirubin	98-107	heme oxygenase 1	Rattus norvegicus	45-49
32038822-11	2009	All biochemical parameters except total-bilirubin were significantly higher in the CCl4-thiopental sod.	Bilirubin	40-49	C-C motif chemokine ligand 4	Rattus norvegicus	83-87
19303655-8	2009	The frequency of homozygous carriers of the 4 UGT1A marker haplotype increased with hyperbilirubinemia affecting all patients with bilirubin levels &gt;85 micromol/l.	Bilirubin	89-98	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	46-51
19389234-1	2009	BACKGROUND: Heme oxygenase-1 is an inducible cytoprotective enzyme which handles oxidative stress by generating anti-oxidant bilirubin and vasodilating carbon monoxide.	Bilirubin	125-134	heme oxygenase 1	Homo sapiens	12-28
19207584-6	2009	Results High incidence and a significant correlation of UGT1A1 gene mutations with increased serum bilirubin level and lower grades of liver tissue inflammatory activity were observed in study participants.	Bilirubin	99-108	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	56-62
19207584-9	2009	Conclusions UGT1A1 gene polymorphism and as its consequence of high serum bilirubin level may promote iron accumulation in hemochromatosis patients by reducing the activity of inflammation.	Bilirubin	74-83	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	12-18
19470256-15	2009	IGF-1 might be associated with bilirubin-induced brain damage.	Bilirubin	31-40	insulin like growth factor 1	Homo sapiens	0-5
18775539-0	2009	Serum bilirubin is inversely associated with insulin resistance and metabolic syndrome among children and adolescents.	Bilirubin	6-15	insulin	Homo sapiens	45-52
18775539-8	2009	The quartiles of the serum total bilirubin levels were inversely correlated with the homeostasis model assessment (HOMA-IR) and insulin while not associated with the serum C-reactive protein (CRP) levels.	Bilirubin	33-42	insulin	Homo sapiens	128-135
19176596-8	2009	Mice pre-treated with HIF-1 alpha or HMOX-1 had a reduced infarct size, improved post-ischaemic function, and increased serum bilirubin (P &lt; 0.05).	Bilirubin	126-135	hypoxia inducible factor 1, alpha subunit	Mus musculus	22-33
19176596-8	2009	Mice pre-treated with HIF-1 alpha or HMOX-1 had a reduced infarct size, improved post-ischaemic function, and increased serum bilirubin (P &lt; 0.05).	Bilirubin	126-135	heme oxygenase 1	Mus musculus	37-43
19336732-0	2009	Cruciferous vegetable feeding alters UGT1A1 activity: diet- and genotype-dependent changes in serum bilirubin in a controlled feeding trial.	Bilirubin	100-109	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	37-43
19336732-2	2009	UGT1A1 glucuronidates bilirubin, estrogens, and several dietary carcinogens.	Bilirubin	22-31	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
18775539-10	2009	The mechanism of the association between MS and total bilirubin may be related to the insulin resistance status.	Bilirubin	54-63	insulin	Homo sapiens	86-93
19131520-4	2009	This allows measurement of bilirubin formation after incorporation of full-length CPR and heme oxygenase-1 (HO-1) into a membrane environment.	Bilirubin	27-36	cytochrome p450 oxidoreductase	Homo sapiens	82-85
19131520-4	2009	This allows measurement of bilirubin formation after incorporation of full-length CPR and heme oxygenase-1 (HO-1) into a membrane environment.	Bilirubin	27-36	heme oxygenase 1	Homo sapiens	90-106
19131520-4	2009	This allows measurement of bilirubin formation after incorporation of full-length CPR and heme oxygenase-1 (HO-1) into a membrane environment.	Bilirubin	27-36	heme oxygenase 1	Homo sapiens	108-112
18551316-2	2009	In pregnant women with CN-1, the foetus is at high risk of being adversely affected by the bilirubin, as unconjugated bilirubin can cross the placenta and is potentially neurotoxic.	Bilirubin	91-100	5'-nucleotidase, cytosolic IA	Homo sapiens	23-27
18551316-2	2009	In pregnant women with CN-1, the foetus is at high risk of being adversely affected by the bilirubin, as unconjugated bilirubin can cross the placenta and is potentially neurotoxic.	Bilirubin	118-127	5'-nucleotidase, cytosolic IA	Homo sapiens	23-27
19238116-2	2009	This study investigated the genetic variants of four bilirubin metabolism genes--heme oxygenase-1 (HMOX1), biliverdin reductase A (BLVRA), solute carrier organic anion transporter family member 1B1 (SLCO1B1), and uridine diphosphate glycosyltransferase 1A1 (UGT1A1)--in relation to TBIL levels and CAD.	Bilirubin	53-62	heme oxygenase 1	Homo sapiens	99-104
19243019-8	2009	Among polymorphisms in other genes, only the (GT)n repeat polymorphism in the HMOX1 promoter region showed association with TBIL levels in the Uyghur population, but not in the Han and Kazak populations.	Bilirubin	124-128	heme oxygenase 1	Homo sapiens	78-83
19127220-9	2009	Coincubation with 10 microM unconjugated bilirubin (UCB)/human serum albumin in a molar ratio of 3:1 and 250 microg/mL ibuprofen caused additional loss of cell viability and increased LDH release (p &lt; 0.01), DNA fragmentation, and activated caspase-3.	Bilirubin	41-50	caspase 3	Rattus norvegicus	244-253
19371317-2	2009	Bilirubin is a typical UGT1A1 substrate.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	23-29
19238116-2	2009	This study investigated the genetic variants of four bilirubin metabolism genes--heme oxygenase-1 (HMOX1), biliverdin reductase A (BLVRA), solute carrier organic anion transporter family member 1B1 (SLCO1B1), and uridine diphosphate glycosyltransferase 1A1 (UGT1A1)--in relation to TBIL levels and CAD.	Bilirubin	53-62	solute carrier organic anion transporter family member 1B1	Homo sapiens	199-206
19214140-9	2009	RESULTS: In rats, the absence of renal MRP2 reduced renal bilirubin glucuronide excretion at pathologic plasma concentrations, modified renal p-aminohippurate excretion and did not affect renal morphine-6-glucuronide excretion.	Bilirubin	58-67	ATP binding cassette subfamily C member 2	Rattus norvegicus	39-43
19133327-0	2009	Antioxidant activity of liver growth factor, a bilirubin covalently bound to albumin.	Bilirubin	47-56	myotrophin	Rattus norvegicus	30-43
19118162-10	2009	The products of HO activity, bilirubin and carbon monoxide (CO, as a CO-releasing molecule, CORM-A1), inhibited Nox4-generated O(2)(*-) and apoptosis caused by TNF-alpha stimulation.	Bilirubin	29-38	NADPH oxidase 4	Sus scrofa	112-116
19118162-10	2009	The products of HO activity, bilirubin and carbon monoxide (CO, as a CO-releasing molecule, CORM-A1), inhibited Nox4-generated O(2)(*-) and apoptosis caused by TNF-alpha stimulation.	Bilirubin	29-38	tumor necrosis factor	Sus scrofa	160-169
19118162-12	2009	The ability of CO and bilirubin to combat TNF-alpha-induced oxidative stress by inhibiting Nox4 activity and/or by O(2)(*-) scavenging, taken together with close intracellular compartmentalization of HO-2 and Nox4 in cerebral vascular endothelium, may contribute to HO-2 cytoprotection against inflammatory cerebrovascular disease.	Bilirubin	22-31	tumor necrosis factor	Sus scrofa	42-51
19118162-12	2009	The ability of CO and bilirubin to combat TNF-alpha-induced oxidative stress by inhibiting Nox4 activity and/or by O(2)(*-) scavenging, taken together with close intracellular compartmentalization of HO-2 and Nox4 in cerebral vascular endothelium, may contribute to HO-2 cytoprotection against inflammatory cerebrovascular disease.	Bilirubin	22-31	NADPH oxidase 4	Sus scrofa	91-95
19129425-6	2009	He developed extremely high serum bilirubin levels, probably attributed to the concomitant viral infection and his G6PD status.	Bilirubin	34-43	glucose-6-phosphate dehydrogenase	Homo sapiens	115-119
19177228-6	2009	The protective effect elicited by CoPP was reproduced by bilirubin addition, suggesting that this molecule may be involved in the protective effect of HO-1 induction in this experimental model.	Bilirubin	57-66	heme oxygenase 1	Rattus norvegicus	151-155
19133327-1	2009	We previously reported that treatment of spontaneously hypertensive rats (SHR) with liver growth factor (LGF), an albumin-bilirubin complex with a covalent bond, reduces blood pressure, improves nitric oxide (NO)-dependent vasodilatation, and exerts vascular antifibrotic actions.	Bilirubin	122-131	myotrophin	Rattus norvegicus	90-103
19328956-9	2009	CA 15-3 levels were also increased among patients with elevated alkaline phosphatase, while elevated CEA was related to ascites, bilirubin, and prothrombin time (PT) levels, as well as alcohol-related cirrhosis.	Bilirubin	129-138	CEA cell adhesion molecule 3	Homo sapiens	101-104
18433409-9	2009	Mean total bilirubin serum levels were 303 +/- 72 micromol/L before and 214 +/- 42 micromol/L after MARS cycles.	Bilirubin	11-20	methionyl-tRNA synthetase 1	Homo sapiens	100-104
19217170-0	2009	Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin.	Bilirubin	113-122	biliverdin reductase A	Homo sapiens	25-45
19217170-1	2009	Degradation of heme requires its conversion to biliverdin (BV) by heme oxygenase, followed by reduction of BV to the free-radical quencher bilirubin (BR) by biliverdin reductase (BVR).	Bilirubin	139-148	biliverdin reductase A	Homo sapiens	157-177
19141701-0	2009	Citrus fruit intake is associated with lower serum bilirubin concentration among women with the UGT1A1*28 polymorphism.	Bilirubin	51-60	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	96-102
19141701-1	2009	UDP-glucuronosyltransferase (UGT) 1A1 glucuronidates bilirubin, estrogens, and xenobiotic compounds.	Bilirubin	53-62	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-37
19141701-3	2009	Previously, we showed that serum bilirubin, a marker of UGT1A1 activity, was lower among individuals homozygous for the UGT1A1*28 polymorphism (7/7) when randomized to a high fruit and vegetable (F&amp;V) diet, whereas there was no effect in individuals with the wild-type (6/6) and heterozygous (6/7) genotypes.	Bilirubin	33-42	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	56-62
19141701-3	2009	Previously, we showed that serum bilirubin, a marker of UGT1A1 activity, was lower among individuals homozygous for the UGT1A1*28 polymorphism (7/7) when randomized to a high fruit and vegetable (F&amp;V) diet, whereas there was no effect in individuals with the wild-type (6/6) and heterozygous (6/7) genotypes.	Bilirubin	33-42	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	120-126
19217170-1	2009	Degradation of heme requires its conversion to biliverdin (BV) by heme oxygenase, followed by reduction of BV to the free-radical quencher bilirubin (BR) by biliverdin reductase (BVR).	Bilirubin	139-148	biliverdin reductase A	Homo sapiens	179-182
19036700-0	2009	Heme oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor: a role for increased bilirubin and ferritin.	Bilirubin	168-177	heme oxygenase 1	Homo sapiens	0-16
19268007-0	2009	Does bilirubin level correspond to interaction of c.-3279T&gt;G and A(TA)7TAA variants in UGT1A1 gene?	Bilirubin	5-14	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	90-96
19268007-1	2009	Promoter variants c.-3279T&gt;G and A(TA)7TAA show decreased level of expression of UDP-glucuronosyl transferase 1A1 (UGT1A1) and consequently reduced activity of the enzyme catalyzing glucuronidation of bilirubin in hepatocytes.	Bilirubin	204-213	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	84-116
19268007-1	2009	Promoter variants c.-3279T&gt;G and A(TA)7TAA show decreased level of expression of UDP-glucuronosyl transferase 1A1 (UGT1A1) and consequently reduced activity of the enzyme catalyzing glucuronidation of bilirubin in hepatocytes.	Bilirubin	204-213	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	118-124
19036700-7	2009	Likewise, bilirubin, Fe chelation, and overexpression of heavy-chain ferritin all induced DAF expression in endothelial cells (EC).	Bilirubin	10-19	CD55 molecule (Cromer blood group)	Homo sapiens	90-93
18950781-1	2009	The effect of chloroform on the chiroselective reaction between bilirubin (BR) and bovine serum albumin (BSA) at the interface between a heptane phase (including CHCl(3)) and an aqueous phase was investigated by means of the absorption and circular dichroism (CD) spectroscopies combined with a centrifugal liquid membrane (CLM) method, and a CLM microscopic fluorescence spectroscopy as well.	Bilirubin	64-73	albumin	Homo sapiens	90-103
20107533-1	2009	Heme oxygenase (HO)-1 is an inducible enzyme that catalyzes the first and rate-limiting step in the oxidative degradation of free heme into ferrous iron, carbon monoxide (CO), and biliverdin (BV), the latter being subsequently converted into bilirubin (BR).	Bilirubin	242-251	heme oxygenase 1	Homo sapiens	0-21
19162549-1	2009	Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that catabolizes free heme into carbon monoxide, iron (which induces the expression of heavy-chain ferritin, an iron-sequestering protein) and biliverdin (which is converted to bilirubin by biliverdin reductase).	Bilirubin	231-240	heme oxygenase 1	Homo sapiens	0-16
19162549-1	2009	Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that catabolizes free heme into carbon monoxide, iron (which induces the expression of heavy-chain ferritin, an iron-sequestering protein) and biliverdin (which is converted to bilirubin by biliverdin reductase).	Bilirubin	231-240	heme oxygenase 1	Homo sapiens	18-22
19162549-2	2009	Over the past few years it has become apparent that these "arms" of the HO-1 system can act protectively in a variety of experimental models of disease; there is also evidence that HO-1 and bilirubin have protective actions in humans.	Bilirubin	190-199	heme oxygenase 1	Homo sapiens	72-76
18950781-0	2009	Effect of chloroform on complexation and chiral aggregation of bilirubin-bovine serum albumin at heptane/water interface.	Bilirubin	63-72	albumin	Homo sapiens	80-93
18713069-0	2009	The cytotoxic effect of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells is modulated by the expression level of MRP1 but not MDR1.	Bilirubin	37-46	ATP binding cassette subfamily C member 1	Homo sapiens	124-128
19092646-8	2009	HO-1 and its antioxidant product bilirubin have been reported to be not only involved in vasoprotection, but to have a similar function in gastric tissue.	Bilirubin	33-42	heme oxygenase 1	Homo sapiens	0-4
18713069-9	2009	These data support the concept that limitation of cellular UCB accumulation, due to UCB export mediated by MRP1, but not MDR1, plays an important role in preventing bilirubin encephalopathy in the newborn.	Bilirubin	165-174	ATP binding cassette subfamily C member 1	Homo sapiens	107-111
19664253-12	2009	At the end of the 48-hour intervention period, bilirubin concentrations were higher in the vasopressin and norepinephrine groups as compared with the terlipressin group (2.3 +/- 2.8 and 2.8 +/- 2.5 vs. 0.9 +/- 0.3 mg.dL-1; each P &lt; 0.05).	Bilirubin	47-56	arginine vasopressin	Homo sapiens	91-102
19881259-6	2009	Severe hyperbilirubinemia is rare in patients with constrictive pericarditis and this case suggests that MRP2 may play a crucial role in compensating for the serum bilirubin in congestive hepatopathy.	Bilirubin	12-21	ATP binding cassette subfamily C member 2	Homo sapiens	105-109
18948018-4	2009	It was shown that albumin derived from a chromatographic process, which had a bilirubin:albumin ratio similar to that observed in plasma, had a vibrant yellow appearance.	Bilirubin	78-87	albumin	Homo sapiens	18-25
18948018-7	2009	Given that the antioxidant properties of bilirubin are well established, it is possible that bilirubin helps protect albumin from oxidation during the pasteurisation step.	Bilirubin	41-50	albumin	Homo sapiens	117-124
18948018-7	2009	Given that the antioxidant properties of bilirubin are well established, it is possible that bilirubin helps protect albumin from oxidation during the pasteurisation step.	Bilirubin	93-102	albumin	Homo sapiens	117-124
19754365-0	2009	The role of ABC transporters in protecting cells from bilirubin toxicity.	Bilirubin	54-63	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	12-15
19754365-2	2009	In this chapter we review the potential role of three ABC proteins in the transport of unconjugated bilirubin (UCB).	Bilirubin	100-109	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	54-57
19754365-8	2009	Although the hepatic expression of MRP3 has been reported to be up-regulated by bilirubin and bilirubin glucuronides, it is unknown whether MRP3 is also involved in the transport of UCB.	Bilirubin	80-89	ATP binding cassette subfamily C member 3	Homo sapiens	35-39
19754365-8	2009	Although the hepatic expression of MRP3 has been reported to be up-regulated by bilirubin and bilirubin glucuronides, it is unknown whether MRP3 is also involved in the transport of UCB.	Bilirubin	94-103	ATP binding cassette subfamily C member 3	Homo sapiens	35-39
19046352-3	2009	In the current study, we determined the effects of HO-1 over-expression and its byproducts iron (Fe(2+)), carbon monoxide (CO) and bilirubin on CH biosynthesis, CH efflux and oxysterol formation in cultured astroglia.	Bilirubin	131-140	heme oxygenase 1	Homo sapiens	51-55
18756386-4	2009	CO and bilirubin significantly inhibited DOX-induced cell death and caspase-3 activation, which may be explained by increased Bcl-2 expression and inhibition of Bax expression.	Bilirubin	7-16	caspase 3	Rattus norvegicus	68-77
18756386-4	2009	CO and bilirubin significantly inhibited DOX-induced cell death and caspase-3 activation, which may be explained by increased Bcl-2 expression and inhibition of Bax expression.	Bilirubin	7-16	BCL2, apoptosis regulator	Rattus norvegicus	126-131
18756386-5	2009	CO and bilirubin up-regulated the heme oxygenase-1 (HO-1), which was required for the protective effect of CO, and a single bilirubin treatment increased DOX-induced apoptosis in H9c2 cells.	Bilirubin	7-16	heme oxygenase 1	Rattus norvegicus	34-50
18756386-5	2009	CO and bilirubin up-regulated the heme oxygenase-1 (HO-1), which was required for the protective effect of CO, and a single bilirubin treatment increased DOX-induced apoptosis in H9c2 cells.	Bilirubin	7-16	heme oxygenase 1	Rattus norvegicus	52-56
18756386-6	2009	The inhibition of HO-1 with ZnPP resulted in a striking increase in apoptosis in the CO, bilirubin, and DOX-treated cells.	Bilirubin	89-98	heme oxygenase 1	Rattus norvegicus	18-22
19601392-3	2009	D-GalN-hepatotoxic rats exhibited elevation in the serum bilirubin level and the activities of the hepatic marker enzymes aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and gamma glutamyl transpeptidase.	Bilirubin	57-66	galanin and GMAP prepropeptide	Rattus norvegicus	2-6
18691743-10	2009	In addition, the concentration of plasma uPAR was positively correlated with prothrombin (PT) (r=0.605, p&lt;0.01) and total bilirubin (TBIL) (r=0.649, p&lt;0.01).	Bilirubin	125-134	plasminogen activator, urokinase receptor	Homo sapiens	41-45
19325249-1	2009	BACKGROUND: The uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) enzyme is responsible for conjugation of the bilirubin in the liver as well as for drug metabolism.	Bilirubin	118-127	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	16-63
19325249-1	2009	BACKGROUND: The uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) enzyme is responsible for conjugation of the bilirubin in the liver as well as for drug metabolism.	Bilirubin	118-127	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	65-71
19103674-8	2009	From 6 to 60 hours after exchange transfusion, there was a significantly lesser drop in total serum bilirubin in the recipients of glucose 6-phosphate dehydrogenase-deficient donor blood compared with recipients of glucose 6-phosphate dehydrogenase-normal blood.	Bilirubin	100-109	glucose-6-phosphate dehydrogenase	Homo sapiens	131-164
19483446-16	2009	This finding in BPKIHS suggests that there is a need of screening cord blood bilirubin and continuous monitoring of bilirubin level in the hospital especially among ABO incompatible neonates.	Bilirubin	116-125	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	165-168
20027140-2	2009	RESULTS: A term newborn delivered by caesarean section (birth weight 2550 g, birth length 47 cm, value of Apgar score 9/10) with good direct adaptation had on the first day of life increased levels of conjugated bilirubin (23 micromol/l), unconjugated bilirubin (55 micromol/l) and C-reactive protein 39.4 g/l.	Bilirubin	212-221	C-reactive protein	Homo sapiens	282-300
18691743-10	2009	In addition, the concentration of plasma uPAR was positively correlated with prothrombin (PT) (r=0.605, p&lt;0.01) and total bilirubin (TBIL) (r=0.649, p&lt;0.01).	Bilirubin	136-140	plasminogen activator, urokinase receptor	Homo sapiens	41-45
19356098-2	2008	In this report, we show findings of the induction of the reporter gene (-3475/+14) of UGT1A1 in HepG2 cells by bilirubin at 50 microM, 100 microM, with human aryl hydrocarbon receptor (hAhR).	Bilirubin	111-120	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	86-92
18981171-2	2008	Of the four families present in mammals, two families, UGT1 and UGT2, use UDP glucuronic acid to glucuronidate bilirubin, steroids, bile acids, drugs, and many other endogenous chemicals and xenobiotics.	Bilirubin	111-120	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	55-59
18981171-2	2008	Of the four families present in mammals, two families, UGT1 and UGT2, use UDP glucuronic acid to glucuronidate bilirubin, steroids, bile acids, drugs, and many other endogenous chemicals and xenobiotics.	Bilirubin	111-120	solute carrier family 35 member A2	Homo sapiens	64-68
18395753-12	2008	The positive effect on reperfusion injury depends on the induction of HO-1, which increases the bilirubin production, an important antioxidant acting as intracellular radical scavenger.	Bilirubin	96-105	heme oxygenase 1	Rattus norvegicus	70-74
19356098-0	2008	Induction of human UGT1A1 by bilirubin through AhR dependent pathway.	Bilirubin	29-38	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	19-25
19356098-0	2008	Induction of human UGT1A1 by bilirubin through AhR dependent pathway.	Bilirubin	29-38	aryl hydrocarbon receptor	Homo sapiens	47-50
19356098-1	2008	UDP-glucuronosyltransferase1A1 (UGT1A1) plays a key role to conjugate bilirubin and preventing jaundice, but there is no report showing the induction of human UGT1A1 (UGT1A1) by bilirubin.	Bilirubin	70-79	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-30
19356098-1	2008	UDP-glucuronosyltransferase1A1 (UGT1A1) plays a key role to conjugate bilirubin and preventing jaundice, but there is no report showing the induction of human UGT1A1 (UGT1A1) by bilirubin.	Bilirubin	70-79	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	32-38
19356098-1	2008	UDP-glucuronosyltransferase1A1 (UGT1A1) plays a key role to conjugate bilirubin and preventing jaundice, but there is no report showing the induction of human UGT1A1 (UGT1A1) by bilirubin.	Bilirubin	178-187	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	32-38
19356098-2	2008	In this report, we show findings of the induction of the reporter gene (-3475/+14) of UGT1A1 in HepG2 cells by bilirubin at 50 microM, 100 microM, with human aryl hydrocarbon receptor (hAhR).	Bilirubin	111-120	aryl hydrocarbon receptor	Homo sapiens	158-183
19356098-2	2008	In this report, we show findings of the induction of the reporter gene (-3475/+14) of UGT1A1 in HepG2 cells by bilirubin at 50 microM, 100 microM, with human aryl hydrocarbon receptor (hAhR).	Bilirubin	111-120	aryl hydrocarbon receptor	Homo sapiens	185-189
19356098-6	2008	These results indicate that the induction of UGT1A1 by bilirubin-AhR did not depend on the elevation of AhR but on ligand binding.	Bilirubin	55-64	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	45-51
19356098-6	2008	These results indicate that the induction of UGT1A1 by bilirubin-AhR did not depend on the elevation of AhR but on ligand binding.	Bilirubin	55-64	aryl hydrocarbon receptor	Homo sapiens	65-68
19356098-7	2008	From this result, we considered that high bilirubin in neonates must induce the elevation of UGT1A1 after birth to prevent jaundice, and bilirubin in adults also regulates the level of UGT1A1.	Bilirubin	42-51	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	93-99
19356098-7	2008	From this result, we considered that high bilirubin in neonates must induce the elevation of UGT1A1 after birth to prevent jaundice, and bilirubin in adults also regulates the level of UGT1A1.	Bilirubin	42-51	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	185-191
19356098-7	2008	From this result, we considered that high bilirubin in neonates must induce the elevation of UGT1A1 after birth to prevent jaundice, and bilirubin in adults also regulates the level of UGT1A1.	Bilirubin	137-146	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	185-191
19356098-8	2008	This is the first report showing direct induction of UGT1A1 by a bilirubin through AhR pathway.	Bilirubin	65-74	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	53-59
19356098-8	2008	This is the first report showing direct induction of UGT1A1 by a bilirubin through AhR pathway.	Bilirubin	65-74	aryl hydrocarbon receptor	Homo sapiens	83-86
18799798-1	2008	Heme oxygenase-1 (HO-1) is up-regulated in response to oxidative stress and catalyzes the degradation of pro-oxidant heme to carbon monoxide (CO), iron, and bilirubin.	Bilirubin	157-166	heme oxygenase 1	Homo sapiens	0-16
18799798-1	2008	Heme oxygenase-1 (HO-1) is up-regulated in response to oxidative stress and catalyzes the degradation of pro-oxidant heme to carbon monoxide (CO), iron, and bilirubin.	Bilirubin	157-166	heme oxygenase 1	Homo sapiens	18-22
18790042-2	2008	UGT1A1 is the major gene influencing bilirubin concentrations.	Bilirubin	37-46	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
18790042-3	2008	Therefore, we investigated an association of bilirubin levels and two polymorphisms in the promoter of UGT1A1 (-53(TA-repeat) polymorphism and T-3279G) in 477 patients with premature, familial CAD and 619 age- and sex-matched controls.	Bilirubin	45-54	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	103-109
19120903-2	2008	Two end products of heme degradation, carbon monoxide (CO) and bilirubin, are involved in the protective role of HO-1 against oxidative injury.	Bilirubin	63-72	heme oxygenase 1	Homo sapiens	113-117
18757529-6	2008	Upregulation of Mrp3 and Mrp4 correlated with elevated serum-conjugated bilirubin and bile acids, respectively.	Bilirubin	72-81	prolactin family 2, subfamily c, member 4	Mus musculus	16-20
18757529-6	2008	Upregulation of Mrp3 and Mrp4 correlated with elevated serum-conjugated bilirubin and bile acids, respectively.	Bilirubin	72-81	prolactin family 2, subfamily c, member 5	Mus musculus	25-29
18832463-2	2008	The basis of the disorder is a 70% reduction in bilirubin glucuronidation catalyzed by the UDP-glucuronosyltransferase 1A1 (UGT1A1), which, in Caucasians, is the result of a homozygous TA insertion into the promoter region of the UGT1A1 gene (UGT1A1*28).	Bilirubin	48-57	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	91-122
18558463-5	2008	Also, elevated bilirubin levels, due to liver impairment, conjugation disorders or UGT1A1 *28 genotype, have been associated with increased incidence of grades 3 intestinal toxicity and neutropenia.	Bilirubin	15-24	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	83-89
30764062-8	2008	The significant advances in understanding the relevance of mutations in UGT not only in glucuronidation of bilirubin, but other drugs and substances, are also reviewed.	Bilirubin	107-116	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	72-75
18794176-0	2008	Revised national guidelines for analysis of CSF for bilirubin in suspected SAH.	Bilirubin	52-61	colony stimulating factor 2	Homo sapiens	44-47
18522630-5	2008	In a univariate analysis there were significant interrelations between serum PSA level and age, BMI, AST, ALT, ALP, TB, HDL and FBS (P &lt; 0.05).	Bilirubin	116-118	kallikrein related peptidase 3	Homo sapiens	77-80
18832463-2	2008	The basis of the disorder is a 70% reduction in bilirubin glucuronidation catalyzed by the UDP-glucuronosyltransferase 1A1 (UGT1A1), which, in Caucasians, is the result of a homozygous TA insertion into the promoter region of the UGT1A1 gene (UGT1A1*28).	Bilirubin	48-57	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	124-130
18832463-2	2008	The basis of the disorder is a 70% reduction in bilirubin glucuronidation catalyzed by the UDP-glucuronosyltransferase 1A1 (UGT1A1), which, in Caucasians, is the result of a homozygous TA insertion into the promoter region of the UGT1A1 gene (UGT1A1*28).	Bilirubin	48-57	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	230-236
18832463-2	2008	The basis of the disorder is a 70% reduction in bilirubin glucuronidation catalyzed by the UDP-glucuronosyltransferase 1A1 (UGT1A1), which, in Caucasians, is the result of a homozygous TA insertion into the promoter region of the UGT1A1 gene (UGT1A1*28).	Bilirubin	48-57	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	230-236
19227417-3	2008	There was strong (score 3) staining of CD56 in the EHBT specimens of 4 patients with more than 1.5 mg/dl of serum total bilirubin in accordance with a decrease of jaundice.	Bilirubin	120-129	neural cell adhesion molecule 1	Homo sapiens	39-43
19032868-8	2008	In all patients, the relative value of increased KCTD9 mRNA was positively correlated with alanine aminotransferase, aspartate aminotransferase, total bilirubin and direct bilirubin but negatively with serum albumin.	Bilirubin	151-160	potassium channel tetramerization domain containing 9	Homo sapiens	49-54
19032868-8	2008	In all patients, the relative value of increased KCTD9 mRNA was positively correlated with alanine aminotransferase, aspartate aminotransferase, total bilirubin and direct bilirubin but negatively with serum albumin.	Bilirubin	172-181	potassium channel tetramerization domain containing 9	Homo sapiens	49-54
18797458-7	2008	The TATA box polymorphism of UGT1A1 was significantly associated with plasma bilirubin levels and behaved as a significant predictor for neutropoenia.	Bilirubin	77-86	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	29-35
18756540-4	2008	The UGT1A1 genotype significantly influenced average bilirubin levels for the common alleles: 6/6 genotype = 2.36 +/- 1.13 mg/dL, 6/7 genotype = 2.90 +/- 1.54 mg/dL, and 7/7 genotype = 4.24 +/- 2.11 mg/dL (P &lt; 0.0001).	Bilirubin	53-62	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	4-10
19080687-8	2008	RESULTS: Compared with those of the model group the levels of ALT, AST, and TBIL of the BDLSC-uPA group were all significantly lower, and the ALB level was higher (all P &lt; 0.05).	Bilirubin	76-80	plasminogen activator, urokinase	Rattus norvegicus	94-97
18706437-8	2008	In JAr, TCA and UDCA up-regulated BVR alpha, SVCT1 and SVCT2, whereas bilirubin up-regulated only SVCT2.	Bilirubin	70-79	solute carrier family 23 member 2	Homo sapiens	98-103
18701634-10	2008	These results demonstrate that induction of HO-1 in mTALH cells reduces the levels of ANG II-mediated superoxide production through the production of both bilirubin and CO.	Bilirubin	155-164	heme oxygenase 1	Mus musculus	44-48
18701634-10	2008	These results demonstrate that induction of HO-1 in mTALH cells reduces the levels of ANG II-mediated superoxide production through the production of both bilirubin and CO.	Bilirubin	155-164	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	86-92
18756540-8	2008	These results validate previous smaller studies and confirm that the UGT1A1 promoter polymorphism exerts a powerful influence on bilirubin levels and the development of gallbladder disease in children with SCA.	Bilirubin	129-138	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	69-75
18805362-0	2008	Tau and S100B proteins as biochemical markers of bilirubin-induced neurotoxicity in term neonates.	Bilirubin	49-58	S100 calcium binding protein B	Homo sapiens	8-13
18805362-4	2008	Serum Tau (r = 0.921, P &lt; 0.001) and S100B (r = 0.927, P &lt; 0.001) levels were correlated with total serum bilirubin levels in all infants.	Bilirubin	112-121	S100 calcium binding protein B	Homo sapiens	40-45
18805362-8	2008	Serum levels of Tau and S100B proteins in jaundiced term newborns were strongly correlated with early-phase bilirubin encephalopathy.	Bilirubin	108-117	S100 calcium binding protein B	Homo sapiens	24-29
18786476-1	2008	Hemoxygenase (HO)-1 is an inducible isoform of the first and rate-controlling enzyme of the degradation of heme into iron, carbon monoxide, and biliverdin, the latter being subsequently converted into bilirubin.	Bilirubin	201-210	heme oxygenase 1	Homo sapiens	0-19
18657588-3	2008	Subsequently, biliverdin IXalpha reductase (BVRA) catalyzes the reduction of biliverdin to bilirubin.	Bilirubin	91-100	biliverdin reductase A	Rattus norvegicus	14-42
18657588-3	2008	Subsequently, biliverdin IXalpha reductase (BVRA) catalyzes the reduction of biliverdin to bilirubin.	Bilirubin	91-100	biliverdin reductase A	Rattus norvegicus	44-48
18584314-6	2008	In addition, the expression of serum granulysin were related to serum total bilirubin and Mayo Clinic risk score.	Bilirubin	76-85	granulysin	Homo sapiens	37-47
17530442-1	2008	UDP-glucuronosyltransferase 1A1 (UGT1A1) plays a key role to conjugate bilirubin and prevent jaundice.	Bilirubin	71-80	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-31
18949895-4	2008	The results showed that significant hepatoprotective effects were obtained against liver damage induced by PCM and CCl4 as evidenced by decreased levels of serum enzymes, glutamate oxaloacetate transaminase (SGOT), glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (SAKP), serum bilirubin (SB) and an almost normal histological architecture of the liver of the treated groups compared to the toxin controls.	Bilirubin	296-305	C-C motif chemokine ligand 4	Rattus norvegicus	115-119
18781851-9	2008	Our results also demonstrate that possessing the *60/*60 plus *28/*28 diplotype in the UGT1A1 gene is a determinant of relatively higher bilirubin values amongst hyperbilirubinemic patients.	Bilirubin	137-146	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	87-93
17530442-1	2008	UDP-glucuronosyltransferase 1A1 (UGT1A1) plays a key role to conjugate bilirubin and prevent jaundice.	Bilirubin	71-80	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	33-39
18371157-2	2008	METHODS &amp; RESULTS: Serum total bilirubin on average was elevated to 12 mg/dL in acute AIH, alanine aminotransferase and aspartate aminotransferase peaked to more than 1000 U/L, and serum gamma-glutamyl transpeptidase was higher in the acute type compared with the chronic type without exacerbation.	Bilirubin	35-44	glutamic--pyruvic transaminase	Homo sapiens	95-119
18603239-4	2008	When gastric fundus muscle strips were depleted of the endogenous antioxidant Cu/Zn superoxide dismutase (SOD) by the Cu-chelator DETCA, electrically induced NANC relaxations were also affected by LY82583; however, biliverdin/bilirubin could not substitute for the loss of Cu/Zn SOD when this specific antioxidant enzyme was depleted.	Bilirubin	226-235	superoxide dismutase 1, soluble	Mus musculus	106-109
18249485-6	2008	RESULTS: Serum Hsp70 levels showed a very strong correlation to the markers of hemolysis (plasma free hemoglobin level, serum lactate dehydrogenase activity, and total bilirubin level) and of hepatocellular injury (serum aminotransferase activities), supported also by principal component analysis.	Bilirubin	168-177	heat shock protein family A (Hsp70) member 4	Homo sapiens	15-20
18338802-2	2008	Here we report that exposure of PC12 and primary rat cerebellar granule neurons to bilirubin (0.5-10 microM) drastically decreases nerve growth factor (NGF)/brain-derived neurotrophic factor signaling to Akt and extracellular signal-regulated kinases (ERKs), indicating a direct interference of the molecule with crucial prosurvival signaling pathways.	Bilirubin	83-92	nerve growth factor	Rattus norvegicus	131-150
18338802-2	2008	Here we report that exposure of PC12 and primary rat cerebellar granule neurons to bilirubin (0.5-10 microM) drastically decreases nerve growth factor (NGF)/brain-derived neurotrophic factor signaling to Akt and extracellular signal-regulated kinases (ERKs), indicating a direct interference of the molecule with crucial prosurvival signaling pathways.	Bilirubin	83-92	nerve growth factor	Rattus norvegicus	152-155
18338802-2	2008	Here we report that exposure of PC12 and primary rat cerebellar granule neurons to bilirubin (0.5-10 microM) drastically decreases nerve growth factor (NGF)/brain-derived neurotrophic factor signaling to Akt and extracellular signal-regulated kinases (ERKs), indicating a direct interference of the molecule with crucial prosurvival signaling pathways.	Bilirubin	83-92	brain-derived neurotrophic factor	Rattus norvegicus	157-190
18338802-2	2008	Here we report that exposure of PC12 and primary rat cerebellar granule neurons to bilirubin (0.5-10 microM) drastically decreases nerve growth factor (NGF)/brain-derived neurotrophic factor signaling to Akt and extracellular signal-regulated kinases (ERKs), indicating a direct interference of the molecule with crucial prosurvival signaling pathways.	Bilirubin	83-92	AKT serine/threonine kinase 1	Rattus norvegicus	204-207
18338802-3	2008	This effect likely involves the scavenging capacity of bilirubin, the latter being able to inhibit, in PC12 cells, accumulation of intracellular reactive oxygen species and phosphorylation of Akt and ERKs in response to extracellular hydrogen peroxide.	Bilirubin	55-64	AKT serine/threonine kinase 1	Rattus norvegicus	192-195
18338802-4	2008	Interestingly, in the absence of exogenous growth factor, bilirubin elicited the phosphorylation of ERKs and of the cAMP responsive element binding (CREB) transcription factor, a signature of NGF-dependent survival signaling.	Bilirubin	58-67	cAMP responsive element binding protein 1	Rattus norvegicus	149-153
18338802-4	2008	Interestingly, in the absence of exogenous growth factor, bilirubin elicited the phosphorylation of ERKs and of the cAMP responsive element binding (CREB) transcription factor, a signature of NGF-dependent survival signaling.	Bilirubin	58-67	nerve growth factor	Rattus norvegicus	192-195
18338802-6	2008	Pharmacological dissection of the signaling cascade triggered by bilirubin revealed that phosphorylation of ERKs requires NO signaling through soluble guanylyl cyclase, and, further upstream, influx of extracellular calcium is necessary for nNOS induction and NO release, likely through calcium-dependent phosphorylation of CREB.	Bilirubin	65-74	nitric oxide synthase 1	Rattus norvegicus	241-245
18338802-6	2008	Pharmacological dissection of the signaling cascade triggered by bilirubin revealed that phosphorylation of ERKs requires NO signaling through soluble guanylyl cyclase, and, further upstream, influx of extracellular calcium is necessary for nNOS induction and NO release, likely through calcium-dependent phosphorylation of CREB.	Bilirubin	65-74	cAMP responsive element binding protein 1	Rattus norvegicus	324-328
18338802-7	2008	Importantly, the cascade elicited by bilirubin through NO and ERK is cytoprotective, as revealed by exacerbated bilirubin toxicity in cultures treated by either NOS or MEK inhibitors.	Bilirubin	37-46	Eph receptor B1	Rattus norvegicus	62-65
18602119-0	2008	Crystallographic analysis of human serum albumin complexed with 4Z,15E-bilirubin-IXalpha.	Bilirubin	71-80	albumin	Homo sapiens	35-48
18602119-3	2008	Bilirubin and its configurational isomers are transported to the liver by human serum albumin (HSA) but their precise binding location(s) on the protein have yet to be determined.	Bilirubin	0-9	albumin	Homo sapiens	80-93
18602119-7	2008	These results provide the first crystal structure of a natural bilirubin pigment bound to serum albumin, challenge some of the present conceptions about HSA-bilirubin interactions, and provide a sound structural framework for finally resolving the long-standing question of where 4Z,15Z-bilirubin-IXalpha binds to the protein.	Bilirubin	63-72	albumin	Homo sapiens	90-103
18412543-1	2008	hBVR (human biliverdin reductase) is an enzyme that reduces biliverdin (the product of haem oxygenases HO-1 and HO-2 activity) to the antioxidant bilirubin.	Bilirubin	146-155	biliverdin reductase A	Homo sapiens	0-4
18412543-1	2008	hBVR (human biliverdin reductase) is an enzyme that reduces biliverdin (the product of haem oxygenases HO-1 and HO-2 activity) to the antioxidant bilirubin.	Bilirubin	146-155	heme oxygenase 2	Homo sapiens	87-116
18443197-0	2008	Serum bilirubin and ferritin levels link heme oxygenase-1 gene promoter polymorphism and susceptibility to coronary artery disease in diabetic patients.	Bilirubin	6-15	heme oxygenase 1	Homo sapiens	41-57
18443197-3	2008	The aim of this study was to assess the association of the length of (GT)(n) repeats in the HO-1 gene promoter with serum bilirubin, markers of iron status, and the development of coronary artery disease (CAD).	Bilirubin	122-131	heme oxygenase 1	Homo sapiens	92-96
18443197-9	2008	With adjustment for both serum bilirubin and ferritin, the effect of HO-1 promoter polymorphism on susceptibility to CAD disappeared.	Bilirubin	31-40	heme oxygenase 1	Homo sapiens	69-73
18443197-10	2008	CONCLUSIONS: Length polymorphism in the HO-1 gene promoter is correlated with susceptibility to CAD in diabetic patients, and this effect might be conveyed through its influence on serum bilirubin and ferritin.	Bilirubin	187-196	heme oxygenase 1	Homo sapiens	40-44
18338802-7	2008	Importantly, the cascade elicited by bilirubin through NO and ERK is cytoprotective, as revealed by exacerbated bilirubin toxicity in cultures treated by either NOS or MEK inhibitors.	Bilirubin	112-121	Eph receptor B1	Rattus norvegicus	62-65
18371157-2	2008	METHODS &amp; RESULTS: Serum total bilirubin on average was elevated to 12 mg/dL in acute AIH, alanine aminotransferase and aspartate aminotransferase peaked to more than 1000 U/L, and serum gamma-glutamyl transpeptidase was higher in the acute type compared with the chronic type without exacerbation.	Bilirubin	35-44	inactive glutathione hydrolase 2	Homo sapiens	191-220
18413659-6	2008	Total bilirubin level was elevated by 2-fold in the Slco1b2(-/-) mice despite the fact that liver enzymes ALT and AST were normal.	Bilirubin	6-15	solute carrier organic anion transporter family, member 1b2	Mus musculus	52-59
18375480-0	2008	Association between the UGT1A1 TA-repeat polymorphism and bilirubin concentration in patients with intermittent claudication: results from the CAVASIC study.	Bilirubin	58-67	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	24-30
18498776-8	2008	Fluorescence properties of albumin were altered by oxidation and, in patients with acute-on-chronic liver failure, by high plasma levels of bilirubin.	Bilirubin	140-149	albumin	Homo sapiens	27-34
18498776-9	2008	This alteration of albumin fluorescence by bilirubin provides evidence for a preferred binding of bilirubin to the fully reduced form of albumin.	Bilirubin	43-52	albumin	Homo sapiens	19-26
18498776-9	2008	This alteration of albumin fluorescence by bilirubin provides evidence for a preferred binding of bilirubin to the fully reduced form of albumin.	Bilirubin	43-52	albumin	Homo sapiens	137-144
18498776-9	2008	This alteration of albumin fluorescence by bilirubin provides evidence for a preferred binding of bilirubin to the fully reduced form of albumin.	Bilirubin	98-107	albumin	Homo sapiens	19-26
18498776-9	2008	This alteration of albumin fluorescence by bilirubin provides evidence for a preferred binding of bilirubin to the fully reduced form of albumin.	Bilirubin	98-107	albumin	Homo sapiens	137-144
18276085-7	2008	Serum AFP levels of jaundiced infants were directly associated with serum indirect bilirubin and gamma-glutamyltranspeptidase concentrations.	Bilirubin	83-92	alpha fetoprotein	Homo sapiens	6-9
18397350-6	2008	Faecal a1AT correlates with total serum bilirubin (TSB) (r = 0.85; p &lt; 0.01).	Bilirubin	40-49	serpin family A member 1	Bos taurus	7-11
18358653-4	2008	RESULTS: Both pre-treatment with DC prior to CCl4 administration and post-treatment with DC after CCl4 administration significantly prevented increases in serum enzymatic activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALP) and total bilirubin (TBIL).	Bilirubin	317-326	C-C motif chemokine ligand 4	Rattus norvegicus	98-102
18358653-4	2008	RESULTS: Both pre-treatment with DC prior to CCl4 administration and post-treatment with DC after CCl4 administration significantly prevented increases in serum enzymatic activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALP) and total bilirubin (TBIL).	Bilirubin	328-332	C-C motif chemokine ligand 4	Rattus norvegicus	98-102
18555605-2	2008	Heme oxygenase-1 (HO-1) is an inducible enzyme that degrades prooxidant heme to radical-scavenging biliverdin/bilirubin in order to protect cells from oxidative stress.	Bilirubin	110-119	heme oxygenase 1	Mus musculus	0-16
18555605-2	2008	Heme oxygenase-1 (HO-1) is an inducible enzyme that degrades prooxidant heme to radical-scavenging biliverdin/bilirubin in order to protect cells from oxidative stress.	Bilirubin	110-119	heme oxygenase 1	Mus musculus	18-22
18759004-6	2008	Hsp70 levels correlated with LVEF, NT-proBNP, serum bilirubin, aspartate aminotransferase, alanine aminotransferase, gammaGT (p &lt; 0.05) concentrations in patients with severe CHF, although no correlation was observed between Hsp70 and CRP, TNF-alpha, or IL-6.	Bilirubin	52-61	heat shock protein family A (Hsp70) member 4	Homo sapiens	0-5
18795698-7	2008	Furthermore, there was significant correlation between postoperative liver function (total bilirubin, albumin) and HGF, IL-6.	Bilirubin	91-100	hepatocyte growth factor	Homo sapiens	115-118
18795698-7	2008	Furthermore, there was significant correlation between postoperative liver function (total bilirubin, albumin) and HGF, IL-6.	Bilirubin	91-100	interleukin 6	Homo sapiens	120-124
18350274-7	2008	There was a significant increase in conjugated bilirubin level in the noncardiac group during vasopressin infusion; noncardiac patients showed higher AST levels with higher cumulative dose or longer duration of infusion.	Bilirubin	47-56	arginine vasopressin	Homo sapiens	94-105
17683490-8	2008	The functional consequences of the induced mrp2 protein in the livers of the DEX-pretreated rats were demonstrated by the increased biliary excretion of conjugated bilirubin.	Bilirubin	164-173	ATP binding cassette subfamily C member 2	Rattus norvegicus	43-47
18567745-3	2008	Moreover, many, but not all, phenolic compounds can have indirect antioxidative effects through induction of heme oxygenase-1 (HO-1), which has antiinflammatory functions via production of antioxidants bilirubin and biliverdin as well as carbon monoxide, thereby contributing to cardiovascular health.	Bilirubin	202-211	heme oxygenase 1	Homo sapiens	109-125
18567745-3	2008	Moreover, many, but not all, phenolic compounds can have indirect antioxidative effects through induction of heme oxygenase-1 (HO-1), which has antiinflammatory functions via production of antioxidants bilirubin and biliverdin as well as carbon monoxide, thereby contributing to cardiovascular health.	Bilirubin	202-211	heme oxygenase 1	Homo sapiens	127-131
24692804-6	2008	Liver enzymes and bilirubin levels were found to be extremely high (AST = 40x normal, ALT = 70x normal, and bilirubin = 13x normal).	Bilirubin	18-27	solute carrier family 17 member 5	Homo sapiens	68-71
18172616-1	2008	Human UDP-glucuronosyltransferase (UGT)1A1 is a critical enzyme responsible for detoxification and metabolism of endogenous and exogenous lipophilic compounds, such as potentially neurotoxic bilirubin and the anticancer drug irinotecan SN-38, via conjugation with glucuronic acid.	Bilirubin	191-200	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	6-42
18004231-6	2008	Insulin-like growth factor 1 increased the survival rate in GalN/LPS-treated rats and prevented the increases of transaminases and total bilirubin in serum.	Bilirubin	137-146	insulin-like growth factor 1	Rattus norvegicus	0-28
18343383-0	2008	Gilbert syndrome, UGT1A1*28 allele, and cardiovascular disease risk: possible protective effects and therapeutic applications of bilirubin.	Bilirubin	129-138	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	18-24
18343383-5	2008	HO and biliverdin reductase control the formation of bilirubin, whereas UGT1A1 controls bilirubin conjugation and clearance.	Bilirubin	88-97	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	72-78
18375480-2	2008	Low plasma concentrations of bilirubin are reportedly associated with the development of coronary and cerebrovascular disease, and bilirubin concentrations are strongly correlated with the enzyme activity of the hepatic uridine diphosphate glucuronosyltransferase (UGT1A1).	Bilirubin	131-140	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	265-271
18375480-4	2008	In a case-control study, we investigated the association between the UGT1A1 polymorphism, bilirubin concentration, and intermittent claudication.	Bilirubin	90-99	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	69-75
18205746-8	2008	Treatment with antioxidants (bilirubin, N-acetylcysteine) protected cells against nicotine-induced cytotoxicity and blocked the upregulation of HO-1, the effects of which were more pronounced in IHOK cells than in HN12 cells.	Bilirubin	29-38	heme oxygenase 1	Homo sapiens	144-148
18442622-5	2008	In bivariate analysis adjusted for race and sex, bilirubin related significantly and positively to large- and small-artery compliances and high-density lipoprotein cholesterol, and inversely to age, body mass index, blood pressure variables, non-high-density lipoprotein cholesterol, triglycerides, and insulin resistance index.	Bilirubin	49-58	insulin	Homo sapiens	303-310
18021224-3	2008	uridine 5"-diphosphate-glucuronosyltransferase 1A1 (UGT1A1) glucuronidates bilirubin for solubilization in the ER.	Bilirubin	75-84	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-50
18443477-6	2008	In addition, arginine vasopressin reduces bile flow and may increase bilirubin concentrations.	Bilirubin	69-78	arginine vasopressin	Homo sapiens	22-33
18021224-3	2008	uridine 5"-diphosphate-glucuronosyltransferase 1A1 (UGT1A1) glucuronidates bilirubin for solubilization in the ER.	Bilirubin	75-84	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	52-58
18021224-6	2008	CONCLUSION: These results strongly suggest that bilirubin is directly delivered to UGT1A1 from ligandin for glucuronidation.	Bilirubin	48-57	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	83-89
18187559-7	2008	Overall, we demonstrated that (1) transient AHR activation and cytochrome P450 1A (CYP1A) induction in livers occurred during ANIT-induced hepatobiliary impairment, (2) pretreatment with an AHR agonist partially protected against acute hepatobiliary alteration, and (3) using a luciferase-based reporter assay, the bile pigment bilirubin weakly activated mouse AHR and binding to medaka-specific CYP1A promoter, resulting in AHR element-driven transcription.	Bilirubin	328-337	cytochrome P450 1A1	Oryzias latipes	83-88
18180294-1	2008	The 9 UDP-glucuronosyltranferases (UGTs) encoded by the UGT1 locus in humans are key enzymes in the metabolism of most drugs as well as endogenous substances such as bile acids, fatty acids, steroids, hormones, neurotransmitters, and bilirubin.	Bilirubin	234-243	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	56-60
18180294-4	2008	Because UGT1A1 in humans is responsible for 100% of the conjugated bilirubin, it followed that newborn Ugt1(-/-) mice developed serum levels of unconjugated bilirubin that were 40-60 times higher than Ugt1(+/-) or wild-type mice.	Bilirubin	67-76	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	8-14
18180294-4	2008	Because UGT1A1 in humans is responsible for 100% of the conjugated bilirubin, it followed that newborn Ugt1(-/-) mice developed serum levels of unconjugated bilirubin that were 40-60 times higher than Ugt1(+/-) or wild-type mice.	Bilirubin	157-166	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	103-107
18180294-5	2008	The result of extreme unconjugated bilirubin in Ugt1(-/-) mice, comparable to the induced levels noted in patients with Crigler-Najjar type 1 disease, is fatal in neonatal Ugt1(-/-) mice within 2 weeks following birth.	Bilirubin	35-44	UDP glucuronosyltransferase 1 family, polypeptide A2	Mus musculus	48-52
18180294-5	2008	The result of extreme unconjugated bilirubin in Ugt1(-/-) mice, comparable to the induced levels noted in patients with Crigler-Najjar type 1 disease, is fatal in neonatal Ugt1(-/-) mice within 2 weeks following birth.	Bilirubin	35-44	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	172-176
18180294-9	2008	Thus, the loss of UGT1A function in Ugt1(-/-) mice leads to a metabolic syndrome that can serve as a model to further investigate the toxicities associated with unconjugated bilirubin and the impact of this disease in humans.	Bilirubin	174-183	Ugt1a@	Mus musculus	18-23
18180294-9	2008	Thus, the loss of UGT1A function in Ugt1(-/-) mice leads to a metabolic syndrome that can serve as a model to further investigate the toxicities associated with unconjugated bilirubin and the impact of this disease in humans.	Bilirubin	174-183	UDP glucuronosyltransferase 1 family, polypeptide A2	Mus musculus	36-40
18379570-1	2008	A premature glucose-6-phosphate dehydrogenase (G-6-PD) deficient neonate was readmitted for exponential rise in the plasma bilirubin concentration to 33.0 mg dl(-1).	Bilirubin	123-132	glucose-6-phosphate dehydrogenase	Homo sapiens	12-45
18379570-1	2008	A premature glucose-6-phosphate dehydrogenase (G-6-PD) deficient neonate was readmitted for exponential rise in the plasma bilirubin concentration to 33.0 mg dl(-1).	Bilirubin	123-132	glucose-6-phosphate dehydrogenase	Homo sapiens	47-53
18187559-7	2008	Overall, we demonstrated that (1) transient AHR activation and cytochrome P450 1A (CYP1A) induction in livers occurred during ANIT-induced hepatobiliary impairment, (2) pretreatment with an AHR agonist partially protected against acute hepatobiliary alteration, and (3) using a luciferase-based reporter assay, the bile pigment bilirubin weakly activated mouse AHR and binding to medaka-specific CYP1A promoter, resulting in AHR element-driven transcription.	Bilirubin	328-337	aryl-hydrocarbon receptor	Mus musculus	190-193
18187559-7	2008	Overall, we demonstrated that (1) transient AHR activation and cytochrome P450 1A (CYP1A) induction in livers occurred during ANIT-induced hepatobiliary impairment, (2) pretreatment with an AHR agonist partially protected against acute hepatobiliary alteration, and (3) using a luciferase-based reporter assay, the bile pigment bilirubin weakly activated mouse AHR and binding to medaka-specific CYP1A promoter, resulting in AHR element-driven transcription.	Bilirubin	328-337	aryl-hydrocarbon receptor	Mus musculus	190-193
18187559-7	2008	Overall, we demonstrated that (1) transient AHR activation and cytochrome P450 1A (CYP1A) induction in livers occurred during ANIT-induced hepatobiliary impairment, (2) pretreatment with an AHR agonist partially protected against acute hepatobiliary alteration, and (3) using a luciferase-based reporter assay, the bile pigment bilirubin weakly activated mouse AHR and binding to medaka-specific CYP1A promoter, resulting in AHR element-driven transcription.	Bilirubin	328-337	aryl hydrocarbon receptor 1b	Oryzias latipes	190-193
18206168-2	2008	We report the heme oxygenase-1 mediated production of bilirubin and its cytoprotective roles in cyclophosphamide induced hemorrhagic cystitis in rats.	Bilirubin	54-63	heme oxygenase 1	Rattus norvegicus	14-30
18206168-11	2008	The elevated expression of inducible nitric oxide synthase and interleukin-1beta in cyclophosphamide induced cystitis was significantly down-regulated by exogenously applied bilirubin.	Bilirubin	174-183	interleukin 1 beta	Rattus norvegicus	63-80
18206168-13	2008	CONCLUSIONS: Cyclophosphamide induced hemorrhagic cystitis is accompanied by endogenous bilirubin production through heme oxygenase-1 induction in the bladder.	Bilirubin	88-97	heme oxygenase 1	Rattus norvegicus	117-133
18174022-4	2008	Heme oxygenase-1 (HO-1) is important for iron homeostasis via catalysis of heme degradation to release iron, carbon monoxide and biliverdin/bilirubin, and may influence iron supply to the intra-erythrocyte falciparum parasites.	Bilirubin	140-149	heme oxygenase 1	Homo sapiens	0-16
18174022-4	2008	Heme oxygenase-1 (HO-1) is important for iron homeostasis via catalysis of heme degradation to release iron, carbon monoxide and biliverdin/bilirubin, and may influence iron supply to the intra-erythrocyte falciparum parasites.	Bilirubin	140-149	heme oxygenase 1	Homo sapiens	18-22
17936791-6	2008	NE inhibitor prevented GalN/LPS-induced increase of enzymes and total bilirubin in serum, which are related to liver injury.	Bilirubin	70-79	elastase, neutrophil expressed	Rattus norvegicus	0-2
17936791-6	2008	NE inhibitor prevented GalN/LPS-induced increase of enzymes and total bilirubin in serum, which are related to liver injury.	Bilirubin	70-79	galanin and GMAP prepropeptide	Rattus norvegicus	23-27
18334180-3	2008	The nuclear receptor CAR (constitutive androstane receptor or NR1I3) and PXR (pregnane X receptor, NR1I2) control phase I (cytochrome P450 2B and 3A), phase II (GSTA, UGT1A1), and transporter (MDR1, SLC21A6, MRP2) genes involved in drugs metabolism, bile acids and bilirubin clearance in response to xenobiotics.	Bilirubin	265-274	nuclear receptor subfamily 1 group I member 3	Homo sapiens	21-24
18334180-3	2008	The nuclear receptor CAR (constitutive androstane receptor or NR1I3) and PXR (pregnane X receptor, NR1I2) control phase I (cytochrome P450 2B and 3A), phase II (GSTA, UGT1A1), and transporter (MDR1, SLC21A6, MRP2) genes involved in drugs metabolism, bile acids and bilirubin clearance in response to xenobiotics.	Bilirubin	265-274	nuclear receptor subfamily 1 group I member 3	Homo sapiens	26-58
18334180-3	2008	The nuclear receptor CAR (constitutive androstane receptor or NR1I3) and PXR (pregnane X receptor, NR1I2) control phase I (cytochrome P450 2B and 3A), phase II (GSTA, UGT1A1), and transporter (MDR1, SLC21A6, MRP2) genes involved in drugs metabolism, bile acids and bilirubin clearance in response to xenobiotics.	Bilirubin	265-274	nuclear receptor subfamily 1 group I member 3	Homo sapiens	62-67
18334180-3	2008	The nuclear receptor CAR (constitutive androstane receptor or NR1I3) and PXR (pregnane X receptor, NR1I2) control phase I (cytochrome P450 2B and 3A), phase II (GSTA, UGT1A1), and transporter (MDR1, SLC21A6, MRP2) genes involved in drugs metabolism, bile acids and bilirubin clearance in response to xenobiotics.	Bilirubin	265-274	nuclear receptor subfamily 1 group I member 2	Homo sapiens	73-76
18334180-3	2008	The nuclear receptor CAR (constitutive androstane receptor or NR1I3) and PXR (pregnane X receptor, NR1I2) control phase I (cytochrome P450 2B and 3A), phase II (GSTA, UGT1A1), and transporter (MDR1, SLC21A6, MRP2) genes involved in drugs metabolism, bile acids and bilirubin clearance in response to xenobiotics.	Bilirubin	265-274	nuclear receptor subfamily 1 group I member 2	Homo sapiens	78-97
18334180-3	2008	The nuclear receptor CAR (constitutive androstane receptor or NR1I3) and PXR (pregnane X receptor, NR1I2) control phase I (cytochrome P450 2B and 3A), phase II (GSTA, UGT1A1), and transporter (MDR1, SLC21A6, MRP2) genes involved in drugs metabolism, bile acids and bilirubin clearance in response to xenobiotics.	Bilirubin	265-274	nuclear receptor subfamily 1 group I member 2	Homo sapiens	99-104
18045581-4	2008	The results showed that the treatment of SNE significantly lowered the CCl4-induced serum levels of hepatic enzyme markers (GOT, GPT, ALP, and total bilirubin), superoxide and hydroxyl radical.	Bilirubin	149-158	C-C motif chemokine ligand 4	Rattus norvegicus	71-75
18215737-7	2008	In addition, the CO donors CORM-1 and CORM-3 and the heme metabolites biliverdin and bilirubin attenuated IL-18-induced EC death via a similar signaling pathway.	Bilirubin	85-94	interleukin 18	Homo sapiens	106-111
19115025-7	2008	Statistically significant differences were found between the mild and severe groups on comparing mean age, duration of stay, quantity of alcohol and parameters of chronic consumption (ferritine, fe, VCM, UBE, AST, bilirubin and Mg) for AST and bilirubin.	Bilirubin	214-223	solute carrier family 17 member 5	Homo sapiens	236-239
18042465-7	2008	Based on these results, we conclude that HO activity is involved in the regulation of p53 expression in a ROS-independent mechanism, and also suggest that the expression of p53 in ARPE-19 cells is associated with heme metabolites such as biliverdin/bilirubin, carbon monoxide, and iron produced by the activity of HO.	Bilirubin	249-258	tumor protein p53	Homo sapiens	173-176
18972232-6	2008	RESULTS: The HGF level was correlated to both gestational week (p=0.007) and birthweight (p=0.015), as well as to total bilirubin on Day 1 (p=0.032).	Bilirubin	120-129	hepatocyte growth factor	Homo sapiens	13-16
19115025-7	2008	Statistically significant differences were found between the mild and severe groups on comparing mean age, duration of stay, quantity of alcohol and parameters of chronic consumption (ferritine, fe, VCM, UBE, AST, bilirubin and Mg) for AST and bilirubin.	Bilirubin	244-253	solute carrier family 17 member 5	Homo sapiens	236-239
18275681-1	2008	BACKGROUND: The aim of the study was to determine the extent of bilirubin interference on two different Beckman-Coulter creatinine methods used on the CX5 PRO/DxC 600 and the DxC 800 systems, respectively.	Bilirubin	64-73	cannabinoid receptor 2	Homo sapiens	151-154
18184470-7	2008	RESULTS: The index of gamma-glutamyltransferase (GGT) was positively correlated to total bilirubin (TB) (r=0.368, P&lt;0.001), but alkaline phosphatase (ALP) was not.	Bilirubin	89-98	gamma-glutamyltransferase light chain family member 3	Homo sapiens	22-47
18184470-7	2008	RESULTS: The index of gamma-glutamyltransferase (GGT) was positively correlated to total bilirubin (TB) (r=0.368, P&lt;0.001), but alkaline phosphatase (ALP) was not.	Bilirubin	89-98	gamma-glutamyltransferase light chain family member 3	Homo sapiens	49-52
18184470-7	2008	RESULTS: The index of gamma-glutamyltransferase (GGT) was positively correlated to total bilirubin (TB) (r=0.368, P&lt;0.001), but alkaline phosphatase (ALP) was not.	Bilirubin	100-102	gamma-glutamyltransferase light chain family member 3	Homo sapiens	22-47
18184470-7	2008	RESULTS: The index of gamma-glutamyltransferase (GGT) was positively correlated to total bilirubin (TB) (r=0.368, P&lt;0.001), but alkaline phosphatase (ALP) was not.	Bilirubin	100-102	gamma-glutamyltransferase light chain family member 3	Homo sapiens	49-52
18275681-4	2008	CONCLUSIONS: There is significantly greater interference by bilirubin on the CX5 PRO/DxC 600 method, which can lead to inaccuracy in the calculation of the estimated glomerular filtration rate by the Modification of Diet in Renal Disease equation.	Bilirubin	60-69	cannabinoid receptor 2	Homo sapiens	77-80
18289070-4	2008	However, experimental observations indicate that the extent of HO-1 induction may be critical because excessive heme degradation may result in toxic levels of CO, bilirubin and, more importantly, iron.	Bilirubin	163-172	heme oxygenase 1	Homo sapiens	63-67
17952380-3	2008	Unconjugated bilirubin is conjugated with glucuronic acid through the reaction of uridine 5"-diphosphate-glucuronosyl transferase 1A1 (UGT1A1).	Bilirubin	13-22	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	82-133
17952380-3	2008	Unconjugated bilirubin is conjugated with glucuronic acid through the reaction of uridine 5"-diphosphate-glucuronosyl transferase 1A1 (UGT1A1).	Bilirubin	13-22	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	135-141
17952380-10	2008	Although the concentration of bilirubin in the UGT1A1 variant was higher than the wild type for the patients in the CAD group, there was no significant difference in the polymorphism of UGT1A1 between the patients in the CAD group and the participants in the control group.	Bilirubin	30-39	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	47-53
18289069-3	2008	The precise underlying mechanisms for HO-1-based protection are not yet completely understood, but appear to involve the protective effects of HO-1 by-products, carbon monoxide (CO), biliverdin/bilirubin and free iron.	Bilirubin	194-203	heme oxygenase 1	Homo sapiens	38-42
18456999-9	2008	eNOS dysfunction has been recently shown to be evoked by increased levels of ADMA in CSF in response to the presence of bilirubin-oxidized fragments (BOXes).	Bilirubin	120-129	colony stimulating factor 2	Homo sapiens	85-88
18289074-1	2008	Heme oxygenase-1 (HO-1) is an inducible rate-limiting enzyme which catalyzes group heme into carbon monoxide, iron and bilirubin.	Bilirubin	119-128	heme oxygenase 1	Homo sapiens	0-16
18289074-1	2008	Heme oxygenase-1 (HO-1) is an inducible rate-limiting enzyme which catalyzes group heme into carbon monoxide, iron and bilirubin.	Bilirubin	119-128	heme oxygenase 1	Homo sapiens	18-22
18195549-6	2008	During the sixth cycle of GEM, total bilirubin gradually increased to 4.0 mg/dL.	Bilirubin	37-46	GTP binding protein overexpressed in skeletal muscle	Homo sapiens	26-29
19003600-1	2008	The substrate spectrum of human UDP-glucuronosyltransferase 1A (UGT1A) proteins includes the glucuronidation of non-steroidal anti-inflammatory drugs, anticonvulsants, chemotherapeutics, steroid hormones, bile acids, and bilirubin.	Bilirubin	221-230	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	32-62
19003600-1	2008	The substrate spectrum of human UDP-glucuronosyltransferase 1A (UGT1A) proteins includes the glucuronidation of non-steroidal anti-inflammatory drugs, anticonvulsants, chemotherapeutics, steroid hormones, bile acids, and bilirubin.	Bilirubin	221-230	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	64-69
17318621-2	2008	In addition to their catalytic function in detoxification, GSTs participate in binding to nonsubstrate ligands such as bilirubin.	Bilirubin	119-128	glutathione S-transferase kappa 1	Homo sapiens	59-63
17318621-8	2008	Total bilirubin levels were found to be significantly higher in patients with the GSTM1 null genotype than in patients with the GSTM1 wild genotype (p = 0.042).	Bilirubin	6-15	glutathione S-transferase mu 1	Homo sapiens	82-87
17318621-8	2008	Total bilirubin levels were found to be significantly higher in patients with the GSTM1 null genotype than in patients with the GSTM1 wild genotype (p = 0.042).	Bilirubin	6-15	glutathione S-transferase mu 1	Homo sapiens	128-133
17318621-10	2008	It is conceivable that there is a relation between GSTM1 gene polymorphism and total bilirubin levels in neonatal jaundice.	Bilirubin	85-94	glutathione S-transferase mu 1	Homo sapiens	51-56
17318621-11	2008	We suggest that GSTM1 gene polymorphisms may affect ligandin functions in hepatocytes, which are important in bilirubin transportation.	Bilirubin	110-119	glutathione S-transferase mu 1	Homo sapiens	16-21
17318621-12	2008	Consequently, patients with the GSTM1 null genotype may have higher total levels of bilirubin.	Bilirubin	84-93	glutathione S-transferase mu 1	Homo sapiens	32-37
18379143-4	2008	We encountered a Japanese woman patient with familial intrahepatic cholestasis type 1 (FIC1) deficiency manifesting BRIC, in whom a rapid and gross elevation of serum total bile acid (TBA) level preceded that of serum total bilirubin level.	Bilirubin	224-233	ATPase phospholipid transporting 8B1	Homo sapiens	116-120
19021267-10	2008	A significant negative correlation was found between the haptoglobin level from the UC taken during delivery and the bilirubin value in the fifth day (r=-0.345; P=0.001).	Bilirubin	117-126	haptoglobin	Homo sapiens	57-68
19024928-0	2008	Polyamine oxidase activity in peripheral blood of newborn infants with neonatal hyperbilirubinemia: is bilirubin an antioxidant?	Bilirubin	85-94	polyamine oxidase	Homo sapiens	0-17
19024928-9	2008	The positive correlation between PAO activity and MDA levels with high bilirubin concentrations (&gt; 200 micromol/L) in newborn infants indicates that in pathological conditions, bilirubin cannot exert its antioxidant function.	Bilirubin	71-80	polyamine oxidase	Homo sapiens	33-36
19024928-9	2008	The positive correlation between PAO activity and MDA levels with high bilirubin concentrations (&gt; 200 micromol/L) in newborn infants indicates that in pathological conditions, bilirubin cannot exert its antioxidant function.	Bilirubin	180-189	polyamine oxidase	Homo sapiens	33-36
18395354-5	2008	BVR was known for a long time solely as an enzyme reducing biliverdin to bilirubin in the heme metabolic pathway.	Bilirubin	73-82	biliverdin reductase A	Homo sapiens	0-3
18392554-2	2008	We investigated whether the (TA)n promoter polymorphism in the UDP-glucuronosyltransferase 1A1 gene (UGT1A1) may modify bilirubin metabolism, influencing bilirubinaemia, predisposition to cholelithiasis and subsequent cholecystectomy, in a group of 153 young SCD patients (mean age 12.0 +/- 9.0 years) predominantly of Bantu beta S haplotype.	Bilirubin	120-129	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	63-94
18392554-2	2008	We investigated whether the (TA)n promoter polymorphism in the UDP-glucuronosyltransferase 1A1 gene (UGT1A1) may modify bilirubin metabolism, influencing bilirubinaemia, predisposition to cholelithiasis and subsequent cholecystectomy, in a group of 153 young SCD patients (mean age 12.0 +/- 9.0 years) predominantly of Bantu beta S haplotype.	Bilirubin	120-129	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	101-107
31178919-4	2008	The oxidative stress inducible green fluorescent protein (GFP) expression in the gst-4::GFP strain was decreased upon exposure to bilirubin at a concentration of 0.5 mM at 24, 48 and 72 hrs.	Bilirubin	130-139	Glutathione S-transferase 4	Caenorhabditis elegans	81-86
31178919-6	2008	Glutathione (GSH) content in the gst-4::GFP strain showed a significant increase as early as 20 hours post treatment with 0.5 mM bilirubin (p &lt; 0.05).	Bilirubin	129-138	Glutathione S-transferase 4	Caenorhabditis elegans	33-38
17823216-8	2007	Inflammatory mRNA expressions for intestine and lung ICAM and TNF were significantly reduced after PC, and these effects were significantly abolished by zinc-protoporphyrin (a specific HO-1 activity inhibitor) and mimicked by bilirubin administration.	Bilirubin	226-235	intercellular adhesion molecule 1	Rattus norvegicus	53-57
18276984-1	2008	Biliverdin reductase (BVR) was known for a long time solely as an enzyme converting biliverdin to bilirubin, the major physiological antioxidant.	Bilirubin	98-107	biliverdin reductase A	Homo sapiens	0-20
18276984-1	2008	Biliverdin reductase (BVR) was known for a long time solely as an enzyme converting biliverdin to bilirubin, the major physiological antioxidant.	Bilirubin	98-107	biliverdin reductase A	Homo sapiens	22-25
18276984-8	2008	In conclusion, BVR together with its substrate, biliverdin, and product, bilirubin, are revealed to be important players in cellular signal transduction pathways, gene expression and oxidative response.	Bilirubin	73-82	biliverdin reductase A	Homo sapiens	15-18
17887916-3	2007	Physiologic heme degradation is catalyzed by two functional isozymes of heme oxygenase, heme oxygenase-1 (HO-1) and HO-2, yielding carbon monoxide, iron, and biliverdin, an immediate precursor to bilirubin.	Bilirubin	196-205	heme oxygenase 1	Homo sapiens	88-104
17887916-3	2007	Physiologic heme degradation is catalyzed by two functional isozymes of heme oxygenase, heme oxygenase-1 (HO-1) and HO-2, yielding carbon monoxide, iron, and biliverdin, an immediate precursor to bilirubin.	Bilirubin	196-205	heme oxygenase 1	Homo sapiens	106-110
17887916-3	2007	Physiologic heme degradation is catalyzed by two functional isozymes of heme oxygenase, heme oxygenase-1 (HO-1) and HO-2, yielding carbon monoxide, iron, and biliverdin, an immediate precursor to bilirubin.	Bilirubin	196-205	heme oxygenase 2	Homo sapiens	116-120
18043502-3	2008	(TA)7 promoter polymorphism in the gene encoding the bilirubin conjugating enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) potentiates hyperbilirubinemia in G-6-PD deficient neonates.	Bilirubin	53-62	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	82-113
18043502-3	2008	(TA)7 promoter polymorphism in the gene encoding the bilirubin conjugating enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) potentiates hyperbilirubinemia in G-6-PD deficient neonates.	Bilirubin	53-62	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	115-121
18043502-3	2008	(TA)7 promoter polymorphism in the gene encoding the bilirubin conjugating enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) potentiates hyperbilirubinemia in G-6-PD deficient neonates.	Bilirubin	53-62	glucose-6-phosphate dehydrogenase	Homo sapiens	157-163
18073533-0	2007	Bilirubin inhibits tumor cell growth via activation of ERK.	Bilirubin	0-9	mitogen-activated protein kinase 1	Homo sapiens	55-58
17919067-7	2007	Accumulating evidence indicates that biliverdin/bilirubin can mediate the protective effects of HO-1 in many disease models, such as IRI and organ transplantation, via its antiinflammatory, antiapoptotic, antiproliferative, and antioxidant properties, as well as its effects on the immune response.	Bilirubin	48-57	heme oxygenase 1	Homo sapiens	96-100
17919068-7	2007	The emergence of biliverdin and bilirubin as a newly defined category of modulators of cell signaling and kinase activity further underscores the critical input of hBVR in the response of intracellular pathways into the external environment.	Bilirubin	32-41	biliverdin reductase A	Homo sapiens	164-168
17823216-8	2007	Inflammatory mRNA expressions for intestine and lung ICAM and TNF were significantly reduced after PC, and these effects were significantly abolished by zinc-protoporphyrin (a specific HO-1 activity inhibitor) and mimicked by bilirubin administration.	Bilirubin	226-235	tumor necrosis factor	Rattus norvegicus	62-65
17973861-0	2007	OATP1B1 polymorphism is a major determinant of serum bilirubin level but not associated with rifampicin-mediated bilirubin elevation.	Bilirubin	53-62	solute carrier organic anion transporter family member 1B1	Homo sapiens	0-7
17973861-14	2007	The direct bilirubin (D.BIL) in the SLCO1B1*15/*15 group was significantly higher than that in the SLCO1B1*1b/*1b group (7.69 +/- 1.81 vs 4.85 +/- 1.81 micromol/L, respectively; P = 0.001).	Bilirubin	11-20	solute carrier organic anion transporter family member 1B1	Homo sapiens	36-43
17973861-18	2007	Genetic polymorphism in SLCO1B1 is a major determinant of interindividual variability in the serum bilirubin level.	Bilirubin	99-108	solute carrier organic anion transporter family member 1B1	Homo sapiens	24-31
17973861-3	2007	Unconjugated bilirubin (UCB) is taken up into hepatocytes by human organic anion transporting polypeptide 1B1 (OATP1B1; encoded for by the SLCO1B1 gene).	Bilirubin	13-22	solute carrier organic anion transporter family member 1B1	Homo sapiens	67-109
17973861-3	2007	Unconjugated bilirubin (UCB) is taken up into hepatocytes by human organic anion transporting polypeptide 1B1 (OATP1B1; encoded for by the SLCO1B1 gene).	Bilirubin	13-22	solute carrier organic anion transporter family member 1B1	Homo sapiens	111-118
17973861-3	2007	Unconjugated bilirubin (UCB) is taken up into hepatocytes by human organic anion transporting polypeptide 1B1 (OATP1B1; encoded for by the SLCO1B1 gene).	Bilirubin	13-22	solute carrier organic anion transporter family member 1B1	Homo sapiens	139-146
17973861-4	2007	The present study was performed to determine the association between SLCO1B1 gene polymorphisms and serum bilirubin levels in vivo.	Bilirubin	106-115	solute carrier organic anion transporter family member 1B1	Homo sapiens	69-76
18281749-1	2007	Crigler-Najjar syndrome type I (CN I) is a rare autosomal recessive disorder due to hepatic dysfunction of uridine diphospho-glucuronosyltransferase (UGT) activity toward bilirubin.	Bilirubin	171-180	5'-nucleotidase, cytosolic IA	Homo sapiens	32-36
17761779-7	2007	Mefenamic acid, a UGT1A9 inhibitor, decreased FYX-051 N(1)- and N(2)-glucuronosyltransferase activities, whereas bilirubin, a UGT1A1 inhibitor, did not affect these activities.	Bilirubin	113-122	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	126-132
17683071-2	2007	In the first capacity, it reduces biliverdin, the product of HO activity, to the effective intracellular antioxidant, bilirubin; as a dual-specificity kinase (S/T/Y) it activates the MAPK and IGF/IRK receptor signal transduction pathways.	Bilirubin	118-127	potassium inwardly rectifying channel subfamily J member 12	Homo sapiens	196-199
17898154-1	2007	The UGT1A1*28 polymorphism is known to correlate with altered clearance of bilirubin (Gilbert syndrome) and drugs such as 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxy camptothecin (CPT-11).	Bilirubin	75-84	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	4-10
17639074-1	2007	Human biliverdin reductase (hBVR) is a dual function enzyme: a catalyst for bilirubin formation and a S/T/Y kinase that shares activators with protein kinase C (PKC) -zeta, including cytokines, insulin, and reactive oxygen species (ROS).	Bilirubin	76-85	biliverdin reductase A	Homo sapiens	28-32
18281749-1	2007	Crigler-Najjar syndrome type I (CN I) is a rare autosomal recessive disorder due to hepatic dysfunction of uridine diphospho-glucuronosyltransferase (UGT) activity toward bilirubin.	Bilirubin	171-180	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	107-148
18281749-1	2007	Crigler-Najjar syndrome type I (CN I) is a rare autosomal recessive disorder due to hepatic dysfunction of uridine diphospho-glucuronosyltransferase (UGT) activity toward bilirubin.	Bilirubin	171-180	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	150-153
18281749-2	2007	Complete inactivation of this enzyme causing CN I lead to accumulation of unconjugated bilirubin in serum and bile.	Bilirubin	87-96	5'-nucleotidase, cytosolic IA	Homo sapiens	45-49
17888052-1	2007	AIM: To investigate bilirubin UDP-glucuronosyltransferase (UGT1A1) gene allele in healthy Chinese neonates, their cord bilirubin level and the subsequent hyperbilirubinemia to determine relationships among them.	Bilirubin	20-29	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	59-65
18004206-2	2007	This work compared the effects of (a) the individual UGT1A1 mutations on the glucuronidation kinetics bilirubin, beta-estradiol, 4-methylumbelliferone (4MU) and 1-naphthol (1NP), and (b) the Y486 mutation, which occurs in the conserved carboxyl terminal domain of UGT1A enzymes, on 4MU, 1NP and naproxen glucuronidation by UGT1A3, UGT1A6 and UGT1A10.	Bilirubin	102-111	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	53-59
18004206-2	2007	This work compared the effects of (a) the individual UGT1A1 mutations on the glucuronidation kinetics bilirubin, beta-estradiol, 4-methylumbelliferone (4MU) and 1-naphthol (1NP), and (b) the Y486 mutation, which occurs in the conserved carboxyl terminal domain of UGT1A enzymes, on 4MU, 1NP and naproxen glucuronidation by UGT1A3, UGT1A6 and UGT1A10.	Bilirubin	102-111	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	53-58
18004206-5	2007	RESULTS: Compared with wild-type UGT1A1, in-vitro clearances for bilirubin, beta-estradiol, 4MU and 1NP glucuronidation by UGT1A1*6 and UGT1A1*27 were reduced by 34-74%, most commonly as a result of a reduction in Vmax.	Bilirubin	65-74	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	123-129
18004206-5	2007	RESULTS: Compared with wild-type UGT1A1, in-vitro clearances for bilirubin, beta-estradiol, 4MU and 1NP glucuronidation by UGT1A1*6 and UGT1A1*27 were reduced by 34-74%, most commonly as a result of a reduction in Vmax.	Bilirubin	65-74	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	123-129
18080921-12	2007	There was a negative correlation between insulin like growth factor binding protein-3 level and serum bilirubin and spleen size.	Bilirubin	102-111	insulin like growth factor binding protein 3	Homo sapiens	41-85
17888052-1	2007	AIM: To investigate bilirubin UDP-glucuronosyltransferase (UGT1A1) gene allele in healthy Chinese neonates, their cord bilirubin level and the subsequent hyperbilirubinemia to determine relationships among them.	Bilirubin	119-128	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	59-65
17551098-1	2007	Heme oxygenase-1 (HO-1) induction in, or carbon monoxide (CO), or bilirubin administration to, donors and/or recipients frequently lead to long-term survival (&gt;100 days) of DBA/2 islets into B6AF1 recipients.	Bilirubin	66-75	DBA2	Homo sapiens	176-181
18214047-5	2007	RESULTS: Multivariate analysis identified the MTHFR-A1298C polymorphism as an independent predictor for maximum levels of bilirubin (p=0.0025) and duration of hyperbilirubinaemia (p=0.013).	Bilirubin	122-131	methylenetetrahydrofolate reductase	Homo sapiens	46-51
18049372-8	2007	In the presence of albumin-bound UCB, bilirubin-induced cytotoxicity in a given cell line is accurately predicted by B(f) irrespective of the source and concentration of albumin, or total bilirubin level.	Bilirubin	38-47	albumin	Homo sapiens	19-26
17825810-8	2007	Of the four assays tested, the Bilirubin DPD reagent (Amresco Inc.) was the most susceptible to the presence of free hemoglobin and will result in a higher rejection rate of neonate capillary heel-stick samples.	Bilirubin	31-40	dihydropyrimidine dehydrogenase	Homo sapiens	41-44
17668877-2	2007	In the liver, Mrp2 transports bilirubin-glucuronide, glutathione (GSH), and drug conjugates into bile, whereas Mrp3 and Mrp4 efflux these entities into blood.	Bilirubin	30-39	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	14-18
17611564-3	2007	Uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) glucuronidates bilirubin in humans, and a polymorphism in the promoter of the gene that encodes it has been associated with hyperbilirubinemia during treatment with a number of drugs.	Bilirubin	72-81	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-47
17611564-3	2007	Uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) glucuronidates bilirubin in humans, and a polymorphism in the promoter of the gene that encodes it has been associated with hyperbilirubinemia during treatment with a number of drugs.	Bilirubin	72-81	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	49-55
17577133-7	2007	Expression of inflammatory genes, including endothelial adhesion molecules, but also IL-1beta and TNF-alpha, was significantly reduced in bilirubin-treated animals.	Bilirubin	138-147	interleukin 1 beta	Mus musculus	85-93
18275716-7	2007	In addition, the expression of GHR mRNA, concentrations of GH and GHBP had a significant negative correlation to the concentration of bilirubin, endotoxin respectively (P &lt; 0.01), and a positive correlation to prealbumin (P &lt; 0.01).	Bilirubin	134-143	growth hormone receptor	Rattus norvegicus	31-34
17915953-10	2007	The R254K full-length form had a specific activity of approximately 200-225 nmol of bilirubin h-1 nmol-1 HO-1 as compared to approximately 140-150 nmol of bilirubin h-1 nmol-1 for the WT form, which contains the 30 kDa contaminant.	Bilirubin	84-93	heme oxygenase 1	Homo sapiens	105-109
18275716-7	2007	In addition, the expression of GHR mRNA, concentrations of GH and GHBP had a significant negative correlation to the concentration of bilirubin, endotoxin respectively (P &lt; 0.01), and a positive correlation to prealbumin (P &lt; 0.01).	Bilirubin	134-143	gonadotropin releasing hormone receptor	Rattus norvegicus	31-33
17577133-7	2007	Expression of inflammatory genes, including endothelial adhesion molecules, but also IL-1beta and TNF-alpha, was significantly reduced in bilirubin-treated animals.	Bilirubin	138-147	tumor necrosis factor	Mus musculus	98-107
17657479-0	2007	Chiral complexation and aggregation of bilirubin with serum albumin at a liquid/liquid interface.	Bilirubin	39-48	albumin	Bos taurus	54-67
17657479-1	2007	The chiral complexation of bilirubin (BR) with bovine and human serum albumin (BSA and HSA), and the aggregation of the complexes at the heptane+chloroform(5:1)/water interface were studied via UV/Vis absorption and circular dichroism (CD) measurements in combination with the centrifugal liquid membrane (CLM) method.	Bilirubin	27-36	albumin	Bos taurus	64-77
17060921-3	2007	Relationship between the concentrations of total serum bilirubin (T-bil) and haplotype structure of UGT1A1 in healthy people were also evaluated.	Bilirubin	55-64	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	100-106
17679649-8	2007	Bilirubin also concentration-dependently reduced NADPH oxidase-dependent superoxide production stimulated by angiotensin II in rat vascular smooth muscle cells and by phorbol 12-myristate 13-acetate in human neutrophil-like HL-60 cells.	Bilirubin	0-9	angiotensinogen	Rattus norvegicus	109-123
17679649-10	2007	Thus, systemic expression of HO-1 suppresses NADPH oxidase activity by mechanisms at least partly mediated by the bile pigment bilirubin, thereby reducing oxidative stress.	Bilirubin	127-136	heme oxygenase 1	Homo sapiens	29-33
17850628-1	2007	Gilbert"s syndrome (GS) is caused by a reduction in the activity of hepatic bilirubin UDP-glucuronosyltransferase (UGT).	Bilirubin	76-85	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	86-113
17850628-1	2007	Gilbert"s syndrome (GS) is caused by a reduction in the activity of hepatic bilirubin UDP-glucuronosyltransferase (UGT).	Bilirubin	76-85	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	115-118
17620344-3	2007	The coexpression of UGT1A4 and UGT1A6 decreased the S(50) and V(max) values of UGT1A1-catalyzed estradiol 3-O-glucuronide formation and increased the V(max) value of UGT1A1-catalyzed bilirubin O-glucuronide formation.	Bilirubin	183-192	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	20-26
17620344-3	2007	The coexpression of UGT1A4 and UGT1A6 decreased the S(50) and V(max) values of UGT1A1-catalyzed estradiol 3-O-glucuronide formation and increased the V(max) value of UGT1A1-catalyzed bilirubin O-glucuronide formation.	Bilirubin	183-192	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	31-37
17620344-3	2007	The coexpression of UGT1A4 and UGT1A6 decreased the S(50) and V(max) values of UGT1A1-catalyzed estradiol 3-O-glucuronide formation and increased the V(max) value of UGT1A1-catalyzed bilirubin O-glucuronide formation.	Bilirubin	183-192	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	79-85
17479230-0	2007	Bilirubin-induced cell toxicity involves PTEN activation through an APE1/Ref-1-dependent pathway.	Bilirubin	0-9	phosphatase and tensin homolog	Homo sapiens	41-45
17479230-0	2007	Bilirubin-induced cell toxicity involves PTEN activation through an APE1/Ref-1-dependent pathway.	Bilirubin	0-9	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	68-72
17479230-0	2007	Bilirubin-induced cell toxicity involves PTEN activation through an APE1/Ref-1-dependent pathway.	Bilirubin	0-9	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	73-78
17963604-13	2007	CONCLUSIONS: Absence of MRP2 localization in the canalicular membrane could be the cause of the blood plasma bilirubin level increase after liver ischemia-reperfusion.	Bilirubin	109-118	ATP binding cassette subfamily C member 2	Rattus norvegicus	24-28
17942060-13	2007	CONCLUSIONS: The MARS system applied by CRRT monitors provide adequate bilirubin clearance percentages and is safe, even in serious patients.	Bilirubin	71-80	methionyl-tRNA synthetase 1	Homo sapiens	17-21
17767467-8	2007	Anti-SS-A/Ro/52kD positive PBC patients had at the time of diagnosis a more advanced histological stage (P = 0.01) and higher serum levels of bilirubin (P = 0.01) and IgM (P = 0.03) compared with negative ones.	Bilirubin	142-151	tripartite motif containing 21	Homo sapiens	5-9
18044280-1	2007	INTRODUCTION: Heme-Oxygenase-1 catalyzes hemoglobin into bilirubin, iron, and carbon monoxide, a well known vasodilator.	Bilirubin	57-66	heme oxygenase 1	Homo sapiens	14-30
17805009-0	2007	Glycoursodeoxycholic acid and interleukin-10 modulate the reactivity of rat cortical astrocytes to unconjugated bilirubin.	Bilirubin	112-121	interleukin 10	Rattus norvegicus	30-44
17678632-10	2007	Moreover, we found that the different products of HO-1, carbon monoxide and bilirubin, exerted anti-inflammatory effects that were additive or synergistic in HT-29 cells stimulated with TNF-alpha.	Bilirubin	76-85	heme oxygenase 1	Homo sapiens	50-54
17867456-4	2007	The aim of the present study was to evaluate the effect of increasing concentrations of haemoglobin, lipids and bilirubin in CRP and Hp serum measurements using these new fluoroimmunoassays.	Bilirubin	112-121	C-reactive protein	Canis lupus familiaris	125-128
17678632-10	2007	Moreover, we found that the different products of HO-1, carbon monoxide and bilirubin, exerted anti-inflammatory effects that were additive or synergistic in HT-29 cells stimulated with TNF-alpha.	Bilirubin	76-85	tumor necrosis factor	Homo sapiens	186-195
17848248-6	2007	RESULTS: The level of serum total and conjugated bilirubin in the inv mouse was 8.1 +/- 3.8 and 4.4 +/- 2.4 mg/dL, respectively, significantly higher than in the wild type.	Bilirubin	49-58	inversin	Mus musculus	66-69
17591699-5	2007	In mice, Galpha12 knockout activated Nrf2 and thereby facilitated heme catabolism to bilirubin and its glucuronosyl conjugations.	Bilirubin	85-94	guanine nucleotide binding protein, alpha 12	Mus musculus	9-17
17522121-17	2007	Increased HO-1 and HO-2 protein expression may increase the production of the antioxidants biliverdin and bilirubin, which are products of heme metabolism.	Bilirubin	106-115	heme oxygenase 2	Homo sapiens	19-23
17478602-9	2007	The correlation of UGT1A1 with total bilirubin levels was mainly due to (TA)(n) repeats in Caucasians but a clear correlation was not observed in African Americans because of the high diversity of haplotypes and the small sample size.	Bilirubin	37-46	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	19-25
17671894-14	2007	On the contrary, HO-1 is highly upregulated and it plays a very important role of antioxidation, because HO-1 generates biliverdin, which being converted to bilirubin exhibits a very potent antioxidative effect, and hence antiapoptosis in tumors.	Bilirubin	157-166	heme oxygenase 1	Homo sapiens	17-21
17517076-12	2007	CONCLUSION: These results indicated disturbances in the canalicular bilirubin transport through MRP2 in the prolonged cases, resulting from severe cholestasis, liver cell injury and vanishing bile ducts.	Bilirubin	68-77	ATP binding cassette subfamily C member 2	Homo sapiens	96-100
17671894-14	2007	On the contrary, HO-1 is highly upregulated and it plays a very important role of antioxidation, because HO-1 generates biliverdin, which being converted to bilirubin exhibits a very potent antioxidative effect, and hence antiapoptosis in tumors.	Bilirubin	157-166	heme oxygenase 1	Homo sapiens	105-109
17671894-15	2007	Thus this oxidation therapy, by inhibiting this HO-1 dependent antioxidant (bilirubin) formation by ZnPP, and by enhancing ROS generation, is expected to offer a powerful therapeutic modality for future anticancer therapy.	Bilirubin	76-85	heme oxygenase 1	Homo sapiens	48-52
17593033-5	2007	Regression analysis showed that serum bilirubin levels and the incidence of gallstones were strongly associated with the number of UGT1A1 [TA] repeats in all subjects (P &lt; 0.0001 and P &lt; 0.01, respectively).	Bilirubin	38-47	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	131-137
17662771-5	2007	RESULTS: Administration of recombinant human growth hormone markedly increased serum insulin-like growth factor and insulin-like growth factor-binding protein 3 levels compared with those seen in group C. Group G showed significantly lower serum concentrations of alanine aminotransferase and total bilirubin after cardiopulmonary bypass termination.	Bilirubin	299-308	growth hormone 1	Homo sapiens	45-59
17508911-7	2007	These novel findings provide a link between the increase in HO-1 activity, with its concurrent enhanced production of carbon monoxide (CO) and bilirubin, a decrease in infiltrated CD11c(+) dendritic cells and an increase in anti-apoptotic proteins, including RSK and BcL-xL, in the interdiction of the diabetic state.	Bilirubin	143-152	heme oxygenase 1	Homo sapiens	60-64
17593033-1	2007	Serum bilirubin levels and predisposition to gallstones in sickle cell disease (SCD) are influenced by genetic variation in the hepatic uridine diphosphate (UDP)-glucuronosyltransferase (UGT1A1) gene, but the association is not consistent.	Bilirubin	6-15	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	187-193
17599282-4	2007	In the present study, the effects of the flavone chrysin and six natural coumarins isolated from various Rutaceous plants on UGT1A6-dependent P-nitrophenol and/or UGT1A1-dependent bilirubin glucuronoconjugation activities were evaluated in cultured rat and human hepatocytes and compared to those of the prototypical UGT1A inducers beta-naphthoflavone, phenobarbital and clofibric acid.	Bilirubin	180-189	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	163-169
17584580-8	2007	There was a positive correlation between BAFF and aspartate aminotransferase (r=0.513, p&lt;0.0001), alanine aminotransferase (r=0.435, p&lt;0.0001), total bilirubin (r=0.419, p&lt;0.01), and soluble CD30 (r=0.579, p&lt;0.0001) in AIH patients.	Bilirubin	156-165	TNF superfamily member 13b	Homo sapiens	41-45
17599282-4	2007	In the present study, the effects of the flavone chrysin and six natural coumarins isolated from various Rutaceous plants on UGT1A6-dependent P-nitrophenol and/or UGT1A1-dependent bilirubin glucuronoconjugation activities were evaluated in cultured rat and human hepatocytes and compared to those of the prototypical UGT1A inducers beta-naphthoflavone, phenobarbital and clofibric acid.	Bilirubin	180-189	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	125-130
17599282-3	2007	In particular, UGT1A1-dependent bilirubin conjugation plays a critical role in the detoxification of neurotoxic bilirubin and phenobarbital-mediated UGT1A1 induction therapy is commonly used in the treatment of unconjugated hyperbilirubinemic diseases such as Crigler-Najjar type II disease.	Bilirubin	32-41	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	15-21
17599282-3	2007	In particular, UGT1A1-dependent bilirubin conjugation plays a critical role in the detoxification of neurotoxic bilirubin and phenobarbital-mediated UGT1A1 induction therapy is commonly used in the treatment of unconjugated hyperbilirubinemic diseases such as Crigler-Najjar type II disease.	Bilirubin	32-41	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	149-155
17669234-7	2007	There were significant differences of serum total bilirubin levels with different grades of positive staining of TLR2 (P less than 0.05).	Bilirubin	50-59	toll like receptor 2	Homo sapiens	113-117
17599282-3	2007	In particular, UGT1A1-dependent bilirubin conjugation plays a critical role in the detoxification of neurotoxic bilirubin and phenobarbital-mediated UGT1A1 induction therapy is commonly used in the treatment of unconjugated hyperbilirubinemic diseases such as Crigler-Najjar type II disease.	Bilirubin	112-121	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	15-21
17599282-4	2007	In the present study, the effects of the flavone chrysin and six natural coumarins isolated from various Rutaceous plants on UGT1A6-dependent P-nitrophenol and/or UGT1A1-dependent bilirubin glucuronoconjugation activities were evaluated in cultured rat and human hepatocytes and compared to those of the prototypical UGT1A inducers beta-naphthoflavone, phenobarbital and clofibric acid.	Bilirubin	180-189	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	125-131
17383825-5	2007	Indicators of necrosis (alanine aminotransferase) and cholestasis (gamma-glutamyl transpeptidase and bilirubins) resulted in significant increases after CCl4 intoxication, but these effects were prevented by curcumin treatment.	Bilirubin	101-111	C-C motif chemokine ligand 4	Rattus norvegicus	153-157
17329113-8	2007	The increase in bilirubin concentration was more distinctive after Fontan operation (p=0.003) with lower AST in this group (p&lt;0.0001).	Bilirubin	16-25	solute carrier family 17 member 5	Homo sapiens	105-108
17763587-7	2007	In the patients with AIHA/Evans syndrome, the quantity of bone marrow CD5+ B lymphocytes showed significantly positive correlation with serum indirect bilirubin level (r = 1.00, P &lt; 0.05).	Bilirubin	151-160	CD5 molecule	Homo sapiens	70-73
17539025-8	2007	Multivariate analysis revealed that high total bilirubin (P = 0.0016; hazard ratio = 1.040 per 1 muM increase; 95% CI 1.015-1.065), HCV infection (P = 0.0095; hazard ratio = 6.955; 95% CI 1.606-30.129), and high HBV DNA level (P = 0.0217; hazard ratio = 1.650; 95% CI 1.076-2.531) affected survival significantly.	Bilirubin	47-56	latexin	Homo sapiens	97-100
17291700-13	2007	AB-4 showed significant hepatoprotective activity against CCl4 induced hepatotoxicity as evident by restoration of serum transaminases, alkaline phosphatase, bilirubin and triglycerides.	Bilirubin	158-167	immunoglobulin kappa variable 4-62	Mus musculus	0-4
17038627-9	2007	In conclusion, these findings provide the rationale for therapeutic options of ICKT and its ingredients that should potentiate bilirubin disposal in vivo by enhancing Mrp2/MRP2-mediated secretory capacities in both livers and kidneys as well as Nrf2-mediated antioxidative actions in the treatment of cholestatic liver diseases associated with jaundice.	Bilirubin	127-136	ATP binding cassette subfamily C member 2	Rattus norvegicus	167-171
17038627-9	2007	In conclusion, these findings provide the rationale for therapeutic options of ICKT and its ingredients that should potentiate bilirubin disposal in vivo by enhancing Mrp2/MRP2-mediated secretory capacities in both livers and kidneys as well as Nrf2-mediated antioxidative actions in the treatment of cholestatic liver diseases associated with jaundice.	Bilirubin	127-136	ATP binding cassette subfamily C member 2	Rattus norvegicus	172-176
17272513-1	2007	Multidrug resistance-associated protein MRP3/Mrp3 (ABCC3) is upregulated in cholestasis, an adaptive response that may protect the liver from accumulation of toxic compounds, such as bile salts and bilirubin conjugates.	Bilirubin	198-207	ATP binding cassette subfamily C member 3	Homo sapiens	40-44
17272513-1	2007	Multidrug resistance-associated protein MRP3/Mrp3 (ABCC3) is upregulated in cholestasis, an adaptive response that may protect the liver from accumulation of toxic compounds, such as bile salts and bilirubin conjugates.	Bilirubin	198-207	ATP binding cassette subfamily C member 3	Homo sapiens	45-49
17272513-1	2007	Multidrug resistance-associated protein MRP3/Mrp3 (ABCC3) is upregulated in cholestasis, an adaptive response that may protect the liver from accumulation of toxic compounds, such as bile salts and bilirubin conjugates.	Bilirubin	198-207	ATP binding cassette subfamily C member 3	Homo sapiens	51-56
17551656-8	2007	After 24 hours of treatment, the decrease in total serum bilirubin levels was significantly greater in the Super LED group (27.9 vs. 10.7%, p&lt;0.01) and duration of phototherapy was significantly shorter in this group (36.8 h vs. 63.8 h, p&lt;0.01).	Bilirubin	57-66	small integral membrane protein 10 like 2A	Homo sapiens	113-116
17551656-9	2007	After 24 hours of treatment, a significantly greater number of patients receiving Super LED phototherapy had reached serum bilirubin concentrations low enough to allow withdrawal of treatment (23 vs. 10, p&lt;0.01).	Bilirubin	123-132	small integral membrane protein 10 like 2A	Homo sapiens	88-91
17650416-12	2007	CONCLUSION: Absence of MRP2 localization in canalicular membrane resulted from missing of radixin expression may be the mechanism of an increase of serum bilirubin after hepatic ischemia-reperfusion.	Bilirubin	154-163	ATP binding cassette subfamily C member 2	Rattus norvegicus	23-27
17416426-2	2007	Heme oxygenase-1 (HO-1) is a key enzyme that is integral to the temporal and spatial regulation of the host response and, together with its products carbon monoxide (CO) and bilirubin, is crucial for maintaining homeostasis and the preservation of function and life.	Bilirubin	174-183	heme oxygenase 1	Homo sapiens	0-16
17416426-2	2007	Heme oxygenase-1 (HO-1) is a key enzyme that is integral to the temporal and spatial regulation of the host response and, together with its products carbon monoxide (CO) and bilirubin, is crucial for maintaining homeostasis and the preservation of function and life.	Bilirubin	174-183	heme oxygenase 1	Homo sapiens	18-22
17242398-2	2007	The products of heme catabolism by HO-1 are ferrous iron, biliverdin (subsequently converted to bilirubin), and carbon monoxide.	Bilirubin	96-105	heme oxygenase 1	Mus musculus	35-39
17650416-12	2007	CONCLUSION: Absence of MRP2 localization in canalicular membrane resulted from missing of radixin expression may be the mechanism of an increase of serum bilirubin after hepatic ischemia-reperfusion.	Bilirubin	154-163	radixin	Rattus norvegicus	90-97
17220234-9	2007	Tranilast glucuronosyltransferase activity was strongly inhibited by bilirubin, a typical UGT1A1 substrate, and N-3, indicating that the phase I metabolite could affect the tranilast glucuronosyltransferase activity.	Bilirubin	69-78	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	90-96
17374650-0	2007	UGT1A1 polymorphism is associated with serum bilirubin concentrations in a randomized, controlled, fruit and vegetable feeding trial.	Bilirubin	45-54	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
17392485-0	2007	Reduction of bilirubin by targeting human heme oxygenase-1 through siRNA.	Bilirubin	13-22	heme oxygenase 1	Homo sapiens	42-58
17392485-3	2007	Heme oxygenase-1 (HO-1) is a rate-limiting enzyme that generates bilirubin.	Bilirubin	65-74	heme oxygenase 1	Homo sapiens	0-16
17392485-3	2007	Heme oxygenase-1 (HO-1) is a rate-limiting enzyme that generates bilirubin.	Bilirubin	65-74	heme oxygenase 1	Homo sapiens	18-22
17347060-1	2007	BACKGROUND AND AIM: To clarify the precise mode of inheritance of Gilbert syndrome, an unconjugated familial hyperbilirubinemia, where impaired bilirubin conjugation is caused by reduced UGT1A1 activity determined by a defective function of the A(TA)6TAA promoter region of the UGT1A1 gene.	Bilirubin	114-123	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	187-193
17347060-1	2007	BACKGROUND AND AIM: To clarify the precise mode of inheritance of Gilbert syndrome, an unconjugated familial hyperbilirubinemia, where impaired bilirubin conjugation is caused by reduced UGT1A1 activity determined by a defective function of the A(TA)6TAA promoter region of the UGT1A1 gene.	Bilirubin	114-123	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	278-284
17397512-6	2007	In multiple regression analysis for each factor of model for end-stage liver disease (MELD) score, only IL-10 level was selected as the significant independent variable for total bilirubin level, only IL-17 level for prothrombin time, and TNF-alpha and IL-1beta levels for creatinine level.	Bilirubin	179-188	interleukin 10	Homo sapiens	104-109
17374650-1	2007	UDP-glucuronosyltransferase (UGT) 1A1 glucuronidates bilirubin, estrogens, and exogenous compounds, including dietary carcinogens.	Bilirubin	53-62	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-37
17598396-11	2007	Observation of correlation between FRAP and determined biochemical variables in the sera have confirmed a statistically significant linear correlation between sera FRAP and bilirubin, hemoglobine, glucose, ALT and triglycerides (p &lt; 0.05).	Bilirubin	173-182	mechanistic target of rapamycin kinase	Homo sapiens	164-168
17444597-5	2007	PON1 activity in clinical sera was closely correlated to serum albumin, total protein and the ratio of albumin to globulins, but was weakly correlated to both direct and total bilirubin in serum.	Bilirubin	176-185	paraoxonase 1	Homo sapiens	0-4
17362574-0	2007	CSF bilirubin-spectrophotometry or direct measurement?	Bilirubin	4-13	colony stimulating factor 2	Homo sapiens	0-3
17279724-2	2007	It is known to inhibit heme-oxygenase-1 (HO-1), resulting in suppressed biliverdin/bilirubin production accompanying lowered antioxidative capacity.	Bilirubin	83-92	heme oxygenase 1	Homo sapiens	23-39
17259247-0	2007	A combinatorial haplotype of the UDP-glucuronosyltransferase 1A1 gene (#60-#IB) increases total bilirubin concentrations in Japanese volunteers.	Bilirubin	96-105	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	33-64
17131376-1	2007	The contribution of heme oxygenase HO-2, the primary source of bilirubin and carbon monoxide (CO) under physiological conditions, to the regulation of vascular function has remained largely unexplored.	Bilirubin	63-72	heme oxygenase 2	Homo sapiens	35-39
17347546-10	2007	L-PGDS generates prostaglandin D2 and also functions as an inter-cellular carrier protein for lipophilic ligands, such as bilirubin and thyroid hormones.	Bilirubin	122-131	prostaglandin D2 synthase	Homo sapiens	0-6
17141959-0	2007	Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin.	Bilirubin	126-135	ATP binding cassette subfamily C member 1	Rattus norvegicus	8-49
17471158-3	2007	This results in a reduced UGT 1A1 expression with 70% less glucuronidation capacity for bilirubin and other UGT1A1 substrates.	Bilirubin	88-97	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	26-33
17325212-3	2007	The boy was a homozygous carrier of short alleles of the heme oxygenase-1 (HO-1) gene GT dinucleotide-repeat promoter polymorphism, which is associated with increased activity and inducibility of the heme-degrading enzyme HO-1, which catalyzes the production of bilirubin.	Bilirubin	262-271	heme oxygenase 1	Homo sapiens	57-73
17325212-3	2007	The boy was a homozygous carrier of short alleles of the heme oxygenase-1 (HO-1) gene GT dinucleotide-repeat promoter polymorphism, which is associated with increased activity and inducibility of the heme-degrading enzyme HO-1, which catalyzes the production of bilirubin.	Bilirubin	262-271	heme oxygenase 1	Homo sapiens	75-79
17325212-5	2007	Because bilirubin production plays a critical role during the neonatal period, the HO-1 promoter polymorphism may be an important genetic factor for the clinical outcome of neonatal hyperbilirubinemia.	Bilirubin	8-17	heme oxygenase 1	Homo sapiens	83-87
17064838-0	2007	A theoretical elucidation of bilirubin interaction with HSA"s lysines: first electrostatic binding site in IIA subdomain.	Bilirubin	29-38	albumin	Homo sapiens	56-59
17064838-1	2007	The electrostatic interaction of amino acid lysines 190, 195 and 199 of human serum albumin (HSA) with bilirubin have been investigated using molecular dynamic simulations, QM and QM/MM minimization methods.	Bilirubin	103-112	albumin	Homo sapiens	78-91
17064838-1	2007	The electrostatic interaction of amino acid lysines 190, 195 and 199 of human serum albumin (HSA) with bilirubin have been investigated using molecular dynamic simulations, QM and QM/MM minimization methods.	Bilirubin	103-112	albumin	Homo sapiens	93-96
17331202-1	2007	When activated by unconjugated bilirubin (UCB), astrocytes are important sources of inflammatory mediators such as TNF-alpha, IL-1beta and IL-6, which may contribute for the neurotoxicity observed during severe neonatal hyperbilirubinemia.	Bilirubin	31-40	interleukin 6	Rattus norvegicus	139-143
17108061-0	2007	Effects of alterations in CAR on bilirubin detoxification in mouse collagen-induced arthritis.	Bilirubin	33-42	nuclear receptor subfamily 1, group I, member 3	Mus musculus	26-29
17108061-2	2007	We investigated whether quantitative and functional changes in CAR and PXR could affect bilirubin detoxification in chronic arthritis.	Bilirubin	88-97	nuclear receptor subfamily 1, group I, member 3	Mus musculus	63-66
17108061-2	2007	We investigated whether quantitative and functional changes in CAR and PXR could affect bilirubin detoxification in chronic arthritis.	Bilirubin	88-97	nuclear receptor subfamily 1, group I, member 2	Mus musculus	71-74
17108061-4	2007	In normal mice treated with CAR agonists, relatively rapid elimination of bilirubin was observed after its intravenous injection.	Bilirubin	74-83	nuclear receptor subfamily 1, group I, member 3	Mus musculus	28-31
17108061-5	2007	Next, we investigated the effects of CAR on bilirubin-detoxifying enzymes and transporters in arthritis.	Bilirubin	44-53	nuclear receptor subfamily 1, group I, member 3	Mus musculus	37-40
17108061-9	2007	These results indicate that alterations to CAR during arthritis affect the elimination of bilirubin because of changes in multiple bilirubin-detoxifying enzymes and transporters.	Bilirubin	90-99	nuclear receptor subfamily 1, group I, member 3	Mus musculus	43-46
17108061-9	2007	These results indicate that alterations to CAR during arthritis affect the elimination of bilirubin because of changes in multiple bilirubin-detoxifying enzymes and transporters.	Bilirubin	131-140	nuclear receptor subfamily 1, group I, member 3	Mus musculus	43-46
16847695-2	2007	This localization supports the function of ABCC2 in the terminal excretion and detoxification of endogenous and xenobiotic organic anions, particularly in the unidirectional efflux of substances conjugated with glutathione, glucuronate, or sulfate, as exemplified by leukotriene C(4), bilirubin glucuronosides, and some steroid sulfates.	Bilirubin	285-294	ATP binding cassette subfamily C member 2	Homo sapiens	43-48
17234505-4	2007	In nine infants (2-8 mo of age, mean age 4.2 mo) who completed the study, serum bilirubin decreased from baseline to 6 h after the end of LCT infusion (from 8.5 +/- 2.0 to 7.8 +/- 1.8 mg/dL, mean +/- SEM, P &lt; 0.05) and MCT/LCT infusion (7.9 +/- 6.5 to 7.1 +/- 6.5 mg/dL, P &lt; 0.05).	Bilirubin	80-89	lactase	Homo sapiens	138-141
16847695-4	2007	Acquired or hereditary deficiency of ABCC2, the latter known as Dubin-Johnson syndrome in humans, causes an increased concentration of bilirubin glucuronosides in blood because of their efflux from hepatocytes via the basolateral ABCC3, which compensates for the deficiency in ABCC2-mediated apical efflux.	Bilirubin	135-144	ATP binding cassette subfamily C member 3	Homo sapiens	230-235
16847695-4	2007	Acquired or hereditary deficiency of ABCC2, the latter known as Dubin-Johnson syndrome in humans, causes an increased concentration of bilirubin glucuronosides in blood because of their efflux from hepatocytes via the basolateral ABCC3, which compensates for the deficiency in ABCC2-mediated apical efflux.	Bilirubin	135-144	ATP binding cassette subfamily C member 2	Homo sapiens	37-42
17148966-2	2007	Polymorphisms at the uridin-glucoronosyl-transferase 1A1 (UGT1A1) and multidrug resistance 1 (MDR1) genes may influence, respectively, bilirubin and ATV plasma concentrations.	Bilirubin	135-144	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	21-56
17006702-10	2007	A significant correlation was found between C-RP levels and total and unconjugated bilirubin levels in FMF patients with attack (r = 0.43, P = 0.01; r = 0.40, P = 0.02, respectively).	Bilirubin	83-92	C-reactive protein	Homo sapiens	44-48
17148966-2	2007	Polymorphisms at the uridin-glucoronosyl-transferase 1A1 (UGT1A1) and multidrug resistance 1 (MDR1) genes may influence, respectively, bilirubin and ATV plasma concentrations.	Bilirubin	135-144	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	58-64
17148966-2	2007	Polymorphisms at the uridin-glucoronosyl-transferase 1A1 (UGT1A1) and multidrug resistance 1 (MDR1) genes may influence, respectively, bilirubin and ATV plasma concentrations.	Bilirubin	135-144	ATP binding cassette subfamily B member 1	Homo sapiens	70-92
17148966-2	2007	Polymorphisms at the uridin-glucoronosyl-transferase 1A1 (UGT1A1) and multidrug resistance 1 (MDR1) genes may influence, respectively, bilirubin and ATV plasma concentrations.	Bilirubin	135-144	ATP binding cassette subfamily B member 1	Homo sapiens	94-98
17378732-5	2007	T-surg, T-isch, time after surgery and plasma bilirubin explained 77% and 51% of the variability of AST and ALT, respectively, for all postoperative measurements (p&lt;0.001 for both).	Bilirubin	46-55	solute carrier family 17 member 5	Homo sapiens	100-103
17245120-5	2007	This combined with experimental data showing anti-atherosclerotic properties of the enzyme heme oxygenase-1 encouraged us to hypothesize that bilirubin and its precursor biliverdin, would act to ameliorate components of atherosclerosis, in a manner similar to what has been shown with HO-1.	Bilirubin	142-151	heme oxygenase 1	Homo sapiens	91-107
17245120-7	2007	We also analyzed the antiproliferative effects of the bile pigments in an in vitro system where bilirubin/biliverdin caused p53 dependent cell cycle arrest by hypophosphorylation of the retinoblastoma tumor suppressor protein in growth factor stimulated VSMCs.	Bilirubin	96-105	tumor protein p53	Homo sapiens	124-127
17020948-3	2006	Therefore, we constructed first-generation recombinant adenoviruses encoding different shRNAs against murine ATP-binding cassette multidrug resistance protein 2 (Abcc2), which is involved in liver transport of bilirubin to bile, and analyzed Abcc2 silencing kinetics.	Bilirubin	210-219	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	109-160
17187418-0	2007	Regulation of the UGT1A1 bilirubin-conjugating pathway: role of a new splicing event at the UGT1A locus.	Bilirubin	25-34	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	18-24
17187418-0	2007	Regulation of the UGT1A1 bilirubin-conjugating pathway: role of a new splicing event at the UGT1A locus.	Bilirubin	25-34	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	18-23
17020887-8	2006	Our results indicate that lipid peroxidation is a significant cause of NO-induced necrosis in human lung epithelial cells, and that the increased NO survival of L1 cells is due at least in part to decreased lipid peroxidation mediated by HO-1-generated biliverdin or bilirubin.	Bilirubin	267-276	heme oxygenase 1	Homo sapiens	238-242
17264799-1	2007	BACKGROUND: Glucuronidation by the UDP glucuronosyltransferase 1A enzymes (UGT1As) is a major pathway for elimination of drugs and endogenous substances, such as bilirubin.	Bilirubin	162-171	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	35-65
18473989-9	2007	Increased ADMA levels result from decreased elimination due to inhibition of the ADMA-hydrolyzing enzyme (DDAH 2) in arteries in spasm by hemoglobin metabolites, bilirubin-oxidized fragments (BOXes).	Bilirubin	162-171	dimethylarginine dimethylaminohydrolase 2	Homo sapiens	106-112
17543193-9	2006	In vivo, administration of the antioxidant bilirubin blocks VCAM-1-dependent leukocyte migration into the lung in experimental asthma.	Bilirubin	43-52	vascular cell adhesion molecule 1	Homo sapiens	60-66
17020948-3	2006	Therefore, we constructed first-generation recombinant adenoviruses encoding different shRNAs against murine ATP-binding cassette multidrug resistance protein 2 (Abcc2), which is involved in liver transport of bilirubin to bile, and analyzed Abcc2 silencing kinetics.	Bilirubin	210-219	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	162-167
17020948-4	2006	C57/BL6 mice injected with these viruses showed significant impairment of Abcc2 function for up to 3 weeks, as reflected by increased serum bilirubin levels.	Bilirubin	140-149	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	74-79
16999951-6	2006	RESULTS: HO-1 expression and activity (5.3+/-2.1 nmol bilirubin/mg protein/h) were only present in ECs from advanced atherosclerotic lesions.	Bilirubin	54-63	heme oxygenase 1	Homo sapiens	9-13
17116800-8	2006	In addition, improvement of liver histologic findings, shortening of activated clotting time, and decrease in serum levels of total bilirubin and alanine aminotransferase were detected with CT-1 treatment.	Bilirubin	132-141	cardiotrophin 1	Rattus norvegicus	190-194
16952291-0	2006	Identification of a novel 974C-->G nonsense mutation of the MRP2/ABCC2 gene in a patient with Dubin-Johnson syndrome and analysis of the effects of rifampicin and ursodeoxycholic acid on serum bilirubin and bile acids.	Bilirubin	193-202	ATP binding cassette subfamily C member 2	Homo sapiens	60-64
16982957-7	2006	Moreover, the heme oxygenase-1 end product bilirubin directly inhibited fully functional NADPH oxidase and seemed to interrupt the assembly and activation of the oxidase.	Bilirubin	43-52	heme oxygenase 1	Homo sapiens	14-30
16822952-12	2006	A CO-releasing compound, CORM-A1, and bilirubin blocked TNF-alpha-induced reactive oxygen species accumulation and apoptosis consistent with the antioxidant and antiapoptotic roles of the end products of HO activity.	Bilirubin	38-47	tumor necrosis factor	Mus musculus	56-65
17058217-1	2006	Gilbert"s disease leads to intermittent non-hemolytic hyperbilirubinemia by a reduction of hepatic bilirubin glucuronidation associated with the presence of the UDP-glucuronosyltransferase (UGT) 1A1*28 polymorphism.	Bilirubin	59-68	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	161-198
17058217-9	2006	Homozygous combinations of UGT1A1*28 with the other variants increased from 7.4% (normal bilirubin to 42 micromol/L) to 41% to 46.1% (43 to &gt;85 micromol/L), and 100% (&gt;85 micromol/L).	Bilirubin	89-98	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	27-33
17079940-8	2006	Serum HMGB1 levels were significantly positively correlated with lactate dehydrogenase, C-reactive protein, and total bilirubin.	Bilirubin	118-127	high mobility group box 1	Homo sapiens	6-11
16952291-0	2006	Identification of a novel 974C-->G nonsense mutation of the MRP2/ABCC2 gene in a patient with Dubin-Johnson syndrome and analysis of the effects of rifampicin and ursodeoxycholic acid on serum bilirubin and bile acids.	Bilirubin	193-202	ATP binding cassette subfamily C member 2	Homo sapiens	65-70
16625420-0	2006	Carbon monoxide and bilirubin from heme oxygenase-1 suppresses reactive oxygen species generation and plasminogen activator inhibitor-1 induction.	Bilirubin	20-29	heme oxygenase 1	Mus musculus	35-51
16909274-2	2006	We also estimated UGT1A genotype-dependent glucuronidation efficiency using the endogenous substrate bilirubin as an indicator.	Bilirubin	101-110	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	18-23
16625420-0	2006	Carbon monoxide and bilirubin from heme oxygenase-1 suppresses reactive oxygen species generation and plasminogen activator inhibitor-1 induction.	Bilirubin	20-29	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	102-135
16899240-2	2006	The plasma level of bilirubin glucuronides, endogenous Mrp2-substrates, was 26 microM at 24 h after CCl(4) treatment.	Bilirubin	20-29	ATP binding cassette subfamily C member 2	Rattus norvegicus	55-59
17487336-0	2006	Bilirubin increases the expression of glucose transporter-1 and the rate of glucose uptake in vascular endothelial cells.	Bilirubin	0-9	solute carrier family 2 member 1	Bos taurus	38-59
16918320-11	2006	MRP2 primarily transports weakly basic drugs and bilirubin from the liver to bile.	Bilirubin	49-58	ATP binding cassette subfamily C member 2	Homo sapiens	0-4
16896007-8	2006	99mTc-DIDA/DISIDA percent retention at 1 hour (1-hour RET) correlated to baseline serum bilirubin (P = .008).	Bilirubin	88-97	ret proto-oncogene	Homo sapiens	54-57
16893190-11	2006	Finally, we found that HRI is inhibited by bilirubin at physiological/pathological levels (IC(50) = 20 microM).	Bilirubin	43-52	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	23-26
17086281-6	2006	The level of plasma uPAR have positive correlation with prothrombin (PT), international normalized ratio (INR) and total bilirubin (P less than 0.01).	Bilirubin	121-130	plasminogen activator, urokinase receptor	Homo sapiens	20-24
16879391-7	2006	CK7 expression was significantly associated with elevated serum bilirubin (&gt; 2 mg/dl) (P = 0.0005) and less nuclear beta-catenin expression (P = 0.003).	Bilirubin	64-73	keratin 7	Homo sapiens	0-3
17180784-6	2006	RESULTS: The comparison of the clinical characteristics and laboratory examinations between the two groups showed that BACH patients had no sex predominance contrasting to female predominance in CH patients, more often presented with prolonged jaundice and clay-colored stool, and had higher bilirubin levels.	Bilirubin	292-301	acyl-CoA thioesterase 7	Homo sapiens	119-123
16791115-11	2006	Bilirubin increases were 2-fold higher in UGT1A1 [TA]7/[TA]7 genotypes.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	42-48
16705756-6	2006	Bilirubins, alanine aminotransferase and collagen (measured as the hepatic hydroxyproline content) were increased significantly by the chronic intoxication with CCl(4) in both iNOS(-/-) and iNOS(+/+) mice; importantly there was no difference between these groups.	Bilirubin	0-10	nitric oxide synthase 2, inducible	Mus musculus	176-180
16690950-11	2006	Finally, bilirubin triggered a reversible redistribution of tight junctional occludin.	Bilirubin	9-18	occludin	Homo sapiens	77-85
16824198-2	2006	Heme oxygenase (HO)-1 is an inducible cytoprotective enzyme that degrades pro-oxidant heme to carbon monoxide (CO) and biliverdin/bilirubin, which are thought to mediate anti-inflammatory and anti-oxidant actions of HO-1.	Bilirubin	130-139	heme oxygenase 1	Mus musculus	0-21
16824198-2	2006	Heme oxygenase (HO)-1 is an inducible cytoprotective enzyme that degrades pro-oxidant heme to carbon monoxide (CO) and biliverdin/bilirubin, which are thought to mediate anti-inflammatory and anti-oxidant actions of HO-1.	Bilirubin	130-139	heme oxygenase 1	Mus musculus	216-220
16785033-2	2006	Heme oxygenases (HO-1/HO-2) and the products of their activity, biliverdin/bilirubin and carbon monoxide (CO), play a physiological role in the vascular system.	Bilirubin	75-84	heme oxygenase 1	Rattus norvegicus	17-26
16504606-1	2006	Mutations in the gene encoding UDP-glucuronosyltransferase 1A1 (UGT1A1) may reduce the glucuronidation of estradiol, bilirubin, etc.	Bilirubin	117-126	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	31-62
16504606-1	2006	Mutations in the gene encoding UDP-glucuronosyltransferase 1A1 (UGT1A1) may reduce the glucuronidation of estradiol, bilirubin, etc.	Bilirubin	117-126	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	64-70
16495208-1	2006	Heme is a strong inducer and substrate of the stress protein heme oxygenase-1 (HO-1), which produces carbon monoxide, iron, and bilirubin.	Bilirubin	128-137	heme oxygenase 1	Homo sapiens	61-77
16495208-1	2006	Heme is a strong inducer and substrate of the stress protein heme oxygenase-1 (HO-1), which produces carbon monoxide, iron, and bilirubin.	Bilirubin	128-137	heme oxygenase 1	Homo sapiens	79-83
16771696-5	2006	Interestingly, the HO-1 repression following TAR plus beta-carotene treatment caused a resynchronization of RAT-1 cell-cycle with a significant increase in the S-phase, and this was probably due to the decreased intracellular levels of carbon monoxide and bilirubin, both of which have antiproliferative effects.	Bilirubin	256-265	heme oxygenase 1	Rattus norvegicus	19-23
16581301-8	2006	An AAV1 UGT1A1 vector with the liver-specific albumin promoter corrected serum bilirubin levels but did not induce UGT1A1 antibodies.	Bilirubin	79-88	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	8-14
16543292-5	2006	In analyses of mRNA expression of the hepatic transporters, elevated Mrp3 expression in EHBR correlated with an increase in serum total bilirubin, suggesting increased bilirubin transport from the liver into the peripheral blood flow.	Bilirubin	136-145	ATP binding cassette subfamily C member 3	Rattus norvegicus	69-73
16543292-5	2006	In analyses of mRNA expression of the hepatic transporters, elevated Mrp3 expression in EHBR correlated with an increase in serum total bilirubin, suggesting increased bilirubin transport from the liver into the peripheral blood flow.	Bilirubin	168-177	ATP binding cassette subfamily C member 3	Rattus norvegicus	69-73
16543292-6	2006	Hepatic heme oxygenase-1 (Ho-1) mRNA, a stress-induced isoform of the rate-limiting enzyme in the catabolism of heme to bilirubin, was markedly upregulated in EHBR at the same dose at which increased serum bilirubin was seen.	Bilirubin	120-129	heme oxygenase 1	Rattus norvegicus	8-24
16543292-6	2006	Hepatic heme oxygenase-1 (Ho-1) mRNA, a stress-induced isoform of the rate-limiting enzyme in the catabolism of heme to bilirubin, was markedly upregulated in EHBR at the same dose at which increased serum bilirubin was seen.	Bilirubin	120-129	heme oxygenase 1	Rattus norvegicus	26-30
16543292-6	2006	Hepatic heme oxygenase-1 (Ho-1) mRNA, a stress-induced isoform of the rate-limiting enzyme in the catabolism of heme to bilirubin, was markedly upregulated in EHBR at the same dose at which increased serum bilirubin was seen.	Bilirubin	206-215	heme oxygenase 1	Rattus norvegicus	8-24
16543292-6	2006	Hepatic heme oxygenase-1 (Ho-1) mRNA, a stress-induced isoform of the rate-limiting enzyme in the catabolism of heme to bilirubin, was markedly upregulated in EHBR at the same dose at which increased serum bilirubin was seen.	Bilirubin	206-215	heme oxygenase 1	Rattus norvegicus	26-30
16543292-7	2006	A time-course study revealed that marked induction of Ho-1 occurred earlier than that of Mrp3, followed by an increase in serum bilirubin.	Bilirubin	128-137	heme oxygenase 1	Rattus norvegicus	54-58
16543292-8	2006	These results suggest that hepatic Mrp3 and Ho-1 may contribute to tienilic acid-enhanced hyperbilirubinemia in EHBR by inducing increased bilirubin transport from the liver into the blood stream, preceded by potentiation of bilirubin formation in the liver.	Bilirubin	95-104	ATP binding cassette subfamily C member 3	Rattus norvegicus	35-39
16543292-8	2006	These results suggest that hepatic Mrp3 and Ho-1 may contribute to tienilic acid-enhanced hyperbilirubinemia in EHBR by inducing increased bilirubin transport from the liver into the blood stream, preceded by potentiation of bilirubin formation in the liver.	Bilirubin	95-104	heme oxygenase 1	Rattus norvegicus	44-48
16543292-8	2006	These results suggest that hepatic Mrp3 and Ho-1 may contribute to tienilic acid-enhanced hyperbilirubinemia in EHBR by inducing increased bilirubin transport from the liver into the blood stream, preceded by potentiation of bilirubin formation in the liver.	Bilirubin	139-148	ATP binding cassette subfamily C member 3	Rattus norvegicus	35-39
16543292-8	2006	These results suggest that hepatic Mrp3 and Ho-1 may contribute to tienilic acid-enhanced hyperbilirubinemia in EHBR by inducing increased bilirubin transport from the liver into the blood stream, preceded by potentiation of bilirubin formation in the liver.	Bilirubin	139-148	heme oxygenase 1	Rattus norvegicus	44-48
16718780-10	2006	Positive linear correlations were seen between IFN-gamma activity and ALT levels (r = 0.339, P &lt; 0.05), and IL-2 activity and TB levels (r = 0.517, P &lt; 0.05).	Bilirubin	129-131	interleukin 2	Homo sapiens	111-115
16563347-1	2006	Heme oxygenase-1 (HO-1) plays a central role in antioxidant and anti-inflammatory actions, which may be mediated through its formation of biliverdin/bilirubin and carbon monoxide.	Bilirubin	149-158	heme oxygenase 1	Mus musculus	0-16
16563347-1	2006	Heme oxygenase-1 (HO-1) plays a central role in antioxidant and anti-inflammatory actions, which may be mediated through its formation of biliverdin/bilirubin and carbon monoxide.	Bilirubin	149-158	heme oxygenase 1	Mus musculus	18-22
16628735-3	2006	UGT1A1 promoter polymorphism is associated both with unconjugated bilirubin level and elevated risk for cholelithiasis in such subset.	Bilirubin	66-75	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
16817017-1	2006	During the course of the study of UGT1A1 induction by bilirubin, we could not detect the induction of the reporter gene (-3174/+14) of human UGT1A1 in HepG2 by bilirubin (Mol.	Bilirubin	54-63	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	34-40
16678019-5	2006	Among the catabolic metabolites of HO-1, both carbon monoxide (CO) and bilirubin were directly involved in the protective role of HO-1 against cisplatin through inhibition of reactive oxygen species generation.	Bilirubin	71-80	heme oxygenase 1	Homo sapiens	35-39
16678019-5	2006	Among the catabolic metabolites of HO-1, both carbon monoxide (CO) and bilirubin were directly involved in the protective role of HO-1 against cisplatin through inhibition of reactive oxygen species generation.	Bilirubin	71-80	heme oxygenase 1	Homo sapiens	130-134
16623877-7	2006	The serum levels of alanine aminotransferase/aspartate aminotransferase (AST/ALT) and bilirubin decreased in rats with STAT3-C.	Bilirubin	86-95	signal transducer and activator of transcription 3	Rattus norvegicus	119-126
21783661-6	2006	Inhibition studies using the differential UGT1A1 inhibitor, bilirubin, suggest that UGT1A1 is not a major contributor to the constitutive BPD glucuronidating activity of control rat liver microsomes.	Bilirubin	60-69	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	42-48
16421286-2	2006	One of the physiological roles of Mrp2 is to transport bilirubin glucuronides from the liver into the bile.	Bilirubin	55-64	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	34-38
16628673-9	2006	Parallel to this observation, recipients of Mdr2+/- livers had significantly higher serum transaminases, alkaline phosphatase, total bilirubin, and bile salt levels, as compared with recipients of wild-type livers.	Bilirubin	133-142	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	44-48
16641879-7	2006	RESULTS: There was a significant correlation between IL-8 concentration and AST, ALP, GGT, total bilirubin and albumin levels in blood serum.	Bilirubin	97-106	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
16609363-9	2006	The hazards ratio (HR) for serious hyperbilirubinaemia (total bilirubin &gt; 2.5 mg/dl) at week 24 was statistically significant only in those patients carrying the UGT1A1*6 (HR 2.87) and UGT1A1*6/*28 (HR 11.42) genotypes.	Bilirubin	40-49	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	165-171
16609363-9	2006	The hazards ratio (HR) for serious hyperbilirubinaemia (total bilirubin &gt; 2.5 mg/dl) at week 24 was statistically significant only in those patients carrying the UGT1A1*6 (HR 2.87) and UGT1A1*6/*28 (HR 11.42) genotypes.	Bilirubin	40-49	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	188-194
16609363-13	2006	The Ki values determined for indinavir inhibition of UGT1A1 are consistent with an interaction in vivo, with an additive effect in patients with already impaired bilirubin glucuronidation activity.	Bilirubin	162-171	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	53-59
16516158-5	2006	Flow cytometry investigations with Red CC-1 showed an increase by more than 2 times suggesting a prooxidative role of bilirubin.	Bilirubin	118-127	C-C motif chemokine ligand 14	Homo sapiens	39-43
16610035-10	2006	CONCLUSION: The genetic epidemiology of GS is variable across ethnic groups and the epistatic interactions among UGT1A1 promoter variants modulate bilirubin glucuronidation.	Bilirubin	147-156	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	113-119
16267566-5	2006	The absence of bilirubin UDP-glucoronyltransferase (UGT1A1) activity in CN patients causes high serum levels of unconjugated bilirubin and brain damage in infancy.	Bilirubin	15-24	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	52-58
16610035-0	2006	Gilbert"s syndrome: High frequency of the (TA)7 TAA allele in India and its interaction with a novel CAT insertion in promoter of the gene for bilirubin UDP-glucuronosyltransferase 1 gene.	Bilirubin	143-152	catalase	Homo sapiens	101-104
16623861-0	2006	Neonatal jaundice and bilirubin UDP-glucuronosyl transferase 1A1 gene polymorphism in Turkish patients.	Bilirubin	22-31	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	32-64
16623861-1	2006	Bilirubin uridine diphosphate-glucuronosyltransferase (B-UGT) is the rate-limiting enzyme for the conjugation of bilirubin with glucuronic acid in its excretion process into the bile.	Bilirubin	113-122	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	57-60
16545694-1	2006	BACKGROUND: Skin injury leads to the release of heme, a potent prooxidant which is degraded by heme oxygenase-1 (HO-1) to carbon monoxide, iron, and biliverdin, subsequently reduced to bilirubin.	Bilirubin	185-194	heme oxygenase 1	Homo sapiens	95-111
16545694-1	2006	BACKGROUND: Skin injury leads to the release of heme, a potent prooxidant which is degraded by heme oxygenase-1 (HO-1) to carbon monoxide, iron, and biliverdin, subsequently reduced to bilirubin.	Bilirubin	185-194	heme oxygenase 1	Homo sapiens	113-117
16267566-8	2006	UGT1A1 gene transfer was confirmed by the presence of bilirubin glucuronides in bile.	Bilirubin	54-63	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-6
16310220-3	2006	The glucuronidation of bilirubin is catalysed by the microsomal UDP-glucuronosyltransferase UGT1A1.	Bilirubin	23-32	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	64-91
16557566-4	2006	Our results show that patients with CF and gallstones are significantly more likely to carry at least one Gilbert UGT1A1 allele compared with stone-free patients (OR 7.3; P = .042) and that these carriers display significantly higher serum levels of unconjugated bilirubin (P = .002).	Bilirubin	263-272	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	114-120
16549520-1	2006	Treatment with phototherapy or with the lipase inhibitor orlistat decreases plasma unconjugated bilirubin (UCB) concentrations in hyperbilirubinemic Gunn rats.	Bilirubin	96-105	lipase G, endothelial type	Rattus norvegicus	40-46
16721655-1	2006	The interactions between bilirubin and human serum albumin (HSA) were studied by isothermal titration calorimetry (ITC) and UV-vis spectrophotometry at 27 degrees C in 100 mM phosphate buffer pH 7.4 containing 1 mM EDTA.	Bilirubin	25-34	albumin	Homo sapiens	45-58
16225954-6	2006	After bile-duct ligation, there were no differences in histological liver damage and serum bile salt levels between Mrp3((-/-)) and WT mice, but Mrp3-deficient mice had lower serum bilirubin glucuronide concentrations.	Bilirubin	181-190	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	145-149
16601269-1	2006	The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2), catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (i.e., biliverdin and bilirubin) and thus constitute a major intracellular source of iron and carbon monoxide (CO).	Bilirubin	199-208	heme oxygenase 1	Homo sapiens	75-79
16601269-1	2006	The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2), catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (i.e., biliverdin and bilirubin) and thus constitute a major intracellular source of iron and carbon monoxide (CO).	Bilirubin	199-208	heme oxygenase 2	Homo sapiens	81-85
16540391-3	2006	Recent studies show that the potent antioxidant actions of bilirubin reflect an amplification mechanism whereby biliverdin reductase (BVR) physiologically regenerates bilirubin in a catalytic cycle.	Bilirubin	59-68	biliverdin reductase A	Homo sapiens	112-132
16540391-3	2006	Recent studies show that the potent antioxidant actions of bilirubin reflect an amplification mechanism whereby biliverdin reductase (BVR) physiologically regenerates bilirubin in a catalytic cycle.	Bilirubin	59-68	biliverdin reductase A	Homo sapiens	134-137
16540391-3	2006	Recent studies show that the potent antioxidant actions of bilirubin reflect an amplification mechanism whereby biliverdin reductase (BVR) physiologically regenerates bilirubin in a catalytic cycle.	Bilirubin	167-176	biliverdin reductase A	Homo sapiens	112-132
16540391-3	2006	Recent studies show that the potent antioxidant actions of bilirubin reflect an amplification mechanism whereby biliverdin reductase (BVR) physiologically regenerates bilirubin in a catalytic cycle.	Bilirubin	167-176	biliverdin reductase A	Homo sapiens	134-137
16540391-7	2006	Further studies showed that BVR surpasses other enzymes by the multifactorial functions of its only end product, bilirubin, including anti-complement activity, and an activity that inhibits antibody-dependent cell-mediated cytotoxicity of lymphocytes.	Bilirubin	113-122	biliverdin reductase A	Homo sapiens	28-31
16540391-8	2006	Since BVR regenerates bilirubin in a redox cycle without significantly increasing the concentration of bilirubin, our results suggest that BVR may represent a novel strategy for the treatment of multiple sclerosis and other oxidative stress-mediated diseases.	Bilirubin	22-31	biliverdin reductase A	Homo sapiens	6-9
16540391-8	2006	Since BVR regenerates bilirubin in a redox cycle without significantly increasing the concentration of bilirubin, our results suggest that BVR may represent a novel strategy for the treatment of multiple sclerosis and other oxidative stress-mediated diseases.	Bilirubin	22-31	biliverdin reductase A	Homo sapiens	139-142
16310220-3	2006	The glucuronidation of bilirubin is catalysed by the microsomal UDP-glucuronosyltransferase UGT1A1.	Bilirubin	23-32	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	92-98
16269573-13	2006	Before being transferred to the mother, biliverdin is extensively converted into bilirubin by biliverdin-IXalpha reductase, whose expression is maintained even though bilirubin excretion into maternal bile is impaired.	Bilirubin	81-90	biliverdin reductase A	Rattus norvegicus	94-122
16269573-13	2006	Before being transferred to the mother, biliverdin is extensively converted into bilirubin by biliverdin-IXalpha reductase, whose expression is maintained even though bilirubin excretion into maternal bile is impaired.	Bilirubin	167-176	biliverdin reductase A	Rattus norvegicus	94-122
16254033-4	2006	In addition, administering bilirubin to only the donor frequently led to long-term survival of DBA/2 islets in B6AF1 recipients and significantly prolonged graft survival of BALB/c islets in C57BL/6 recipients.	Bilirubin	27-36	DBA2	Homo sapiens	95-100
16677090-5	2006	Of the various HSPs, heme oxygenase-I (HO-1), by generating the vasoactive molecule carbon monoxide and the potent antioxidant bilirubin, could represent a protective system potentially active against brain oxidative injury.	Bilirubin	127-136	heme oxygenase 1	Homo sapiens	39-43
16150853-10	2006	Individual ASBT mRNA expression was inversely correlated with bile acid and bilirubin plasma concentrations.	Bilirubin	76-85	solute carrier family 10 member 2	Homo sapiens	11-15
16458308-0	2006	Multidrug resistance associated protein 1 protects against bilirubin-induced cytotoxicity.	Bilirubin	59-68	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	0-41
16458308-1	2006	We have shown that multidrug resistance associated protein 1 (MRP1) mediates ATP-dependent extrusion of bilirubin, possibly limiting its potentially toxic accumulation in cells.	Bilirubin	104-113	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	19-60
16458308-1	2006	We have shown that multidrug resistance associated protein 1 (MRP1) mediates ATP-dependent extrusion of bilirubin, possibly limiting its potentially toxic accumulation in cells.	Bilirubin	104-113	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	62-66
16388906-3	2006	The binding affinity of bilirubin to microspheres was enhanced when rat serum albumin (RSA) was loaded into the microspheres.	Bilirubin	24-33	albumin	Rattus norvegicus	72-85
16565602-5	2006	PXR and CAR coordinately regulate not only bile acid metabolism and transport, but also bilirubin clearance.	Bilirubin	88-97	nuclear receptor subfamily 1 group I member 2	Homo sapiens	0-3
16565602-5	2006	PXR and CAR coordinately regulate not only bile acid metabolism and transport, but also bilirubin clearance.	Bilirubin	88-97	nuclear receptor subfamily 1 group I member 3	Homo sapiens	8-11
16549178-8	2006	After a month of HLA-G decrease in serum levels, liver function tests such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), direct bilirubin (DB), total bilirubin (TB), and alkaline phosphatase (ALP) were above normal levels, suggesting liver dysfunction or rejection.	Bilirubin	151-160	major histocompatibility complex, class I, G	Homo sapiens	17-22
16549178-8	2006	After a month of HLA-G decrease in serum levels, liver function tests such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), direct bilirubin (DB), total bilirubin (TB), and alkaline phosphatase (ALP) were above normal levels, suggesting liver dysfunction or rejection.	Bilirubin	173-182	major histocompatibility complex, class I, G	Homo sapiens	17-22
16467537-6	2006	In agreement with these results, mimickers of HO-1 products, such as bilirubin, ferrous iron, and a carbon monoxide-releasing molecule, reduced IFN-gamma-induced iNOS expression and/or NO release.	Bilirubin	69-78	interferon gamma	Homo sapiens	144-153
16467537-6	2006	In agreement with these results, mimickers of HO-1 products, such as bilirubin, ferrous iron, and a carbon monoxide-releasing molecule, reduced IFN-gamma-induced iNOS expression and/or NO release.	Bilirubin	69-78	nitric oxide synthase 2	Homo sapiens	162-166
16254033-5	2006	Donor treatment with bilirubin up-regulated mRNA expression of protective genes such as HO-1 and bcl-2 and suppressed proinflammatory and proapoptotic genes including monocyte chemoattractant protein-1 and caspase-3 and -8 in the islet grafts before transplantation.	Bilirubin	21-30	heme oxygenase 1	Homo sapiens	88-92
16254033-5	2006	Donor treatment with bilirubin up-regulated mRNA expression of protective genes such as HO-1 and bcl-2 and suppressed proinflammatory and proapoptotic genes including monocyte chemoattractant protein-1 and caspase-3 and -8 in the islet grafts before transplantation.	Bilirubin	21-30	BCL2 apoptosis regulator	Homo sapiens	97-102
16254033-5	2006	Donor treatment with bilirubin up-regulated mRNA expression of protective genes such as HO-1 and bcl-2 and suppressed proinflammatory and proapoptotic genes including monocyte chemoattractant protein-1 and caspase-3 and -8 in the islet grafts before transplantation.	Bilirubin	21-30	C-C motif chemokine ligand 2	Homo sapiens	167-201
16254033-5	2006	Donor treatment with bilirubin up-regulated mRNA expression of protective genes such as HO-1 and bcl-2 and suppressed proinflammatory and proapoptotic genes including monocyte chemoattractant protein-1 and caspase-3 and -8 in the islet grafts before transplantation.	Bilirubin	21-30	caspase 3	Homo sapiens	206-222
16958604-2	2006	Our purpose was to verify if determination of total bilirubin (TBIL) in whole blood on an ABL 735 blood gas analyzer with a spectrophotometer module could provide an analytical alternative to chemical methods of TBIL measurement.	Bilirubin	52-61	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	90-93
16337205-3	2006	We have constructed a self-inactivating lentiviral vector (LV-ALBUGT) that expresses the human bilirubin UDP-glucuronosyltransferase (UGT1A1) from a liver-specific promoter.	Bilirubin	95-104	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	134-140
16958604-2	2006	Our purpose was to verify if determination of total bilirubin (TBIL) in whole blood on an ABL 735 blood gas analyzer with a spectrophotometer module could provide an analytical alternative to chemical methods of TBIL measurement.	Bilirubin	63-67	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	90-93
16958604-14	2006	CONCLUSIONS: The ABL 735 instrument is reliable for measuring TBIL in 70-microL whole blood samples from neonates.	Bilirubin	62-66	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	17-20
16369191-7	2006	FN prevented increases in the concentrations of serum enzymes and total bilirubin related to liver injury.	Bilirubin	72-81	fibronectin 1	Mus musculus	0-2
16943657-2	2006	HO-1 degradation of heme yields biliverdin, bilirubin, carbon monoxide and iron.	Bilirubin	44-53	heme oxygenase 1	Homo sapiens	0-4
16697692-9	2006	This study shows an antiapoptotic effect of heme oxygenase-1 in colon cancer cells which could be mediated by the formation of bilirubin and biliverdin.	Bilirubin	127-136	heme oxygenase 1	Homo sapiens	44-60
16325792-3	2006	RESULTS: The coefficient of variation for SHBG kits from both manufacturers was in the range of 3.9-7.7% (between-run) and 0.95-5.0% (within-run), free of interference from hemoglobin, bilirubin, lipid, and rheumatoid factor, and linear up to at least 170 nM SHBG.	Bilirubin	185-194	sex hormone binding globulin	Homo sapiens	42-46
16171463-1	2005	Bilirubin glucuronidation, catalysed by UGT1A1 [UGT (UDP glucuronosyltransferase) isoform 1A1, EC 2.4.1.17], is critical for biliary elimination of bilirubin.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	40-46
16246303-6	2005	In addition, HO-1 or bilirubin could modulate the transcript activities of Stat-1-driven gene expression in luciferase reporter assays.	Bilirubin	21-30	signal transducer and activator of transcription 1	Homo sapiens	75-81
16541400-0	2006	Bilirubin degradation by uncoupled cytochrome P450.	Bilirubin	0-9	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	35-50
16541400-3	2006	Degradation of bilirubin takes place (a) on interaction with oxidative free radicals and (b) when cytochrome P450 (CYP) enzymes are uncoupled by polyhalogenated substrate analogues.	Bilirubin	15-24	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	98-113
16541400-3	2006	Degradation of bilirubin takes place (a) on interaction with oxidative free radicals and (b) when cytochrome P450 (CYP) enzymes are uncoupled by polyhalogenated substrate analogues.	Bilirubin	15-24	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	115-118
16246303-3	2005	Among three catalytic products of HO, bilirubin, but not carbon monoxide or ferrous iron, mediated the suppressive effects of HO through the reduction of mRNA levels of Stat-1-dependent class II transactivator.	Bilirubin	38-47	signal transducer and activator of transcription 1	Homo sapiens	169-175
16171463-1	2005	Bilirubin glucuronidation, catalysed by UGT1A1 [UGT (UDP glucuronosyltransferase) isoform 1A1, EC 2.4.1.17], is critical for biliary elimination of bilirubin.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	40-43
16171463-1	2005	Bilirubin glucuronidation, catalysed by UGT1A1 [UGT (UDP glucuronosyltransferase) isoform 1A1, EC 2.4.1.17], is critical for biliary elimination of bilirubin.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	53-80
16171463-1	2005	Bilirubin glucuronidation, catalysed by UGT1A1 [UGT (UDP glucuronosyltransferase) isoform 1A1, EC 2.4.1.17], is critical for biliary elimination of bilirubin.	Bilirubin	148-157	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	40-46
16171463-1	2005	Bilirubin glucuronidation, catalysed by UGT1A1 [UGT (UDP glucuronosyltransferase) isoform 1A1, EC 2.4.1.17], is critical for biliary elimination of bilirubin.	Bilirubin	148-157	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	40-43
16171463-1	2005	Bilirubin glucuronidation, catalysed by UGT1A1 [UGT (UDP glucuronosyltransferase) isoform 1A1, EC 2.4.1.17], is critical for biliary elimination of bilirubin.	Bilirubin	148-157	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	53-80
16171463-5	2005	Expression of mutagenized UGT1A1 plasmids showed that substitution of any of the seven cysteine residues located within the endoplasmic reticulum cisternae (including those mutated in patients A and B) abolished UGT1A1 activity or markedly increased its apparent K(m) for bilirubin.	Bilirubin	272-281	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	26-32
16171463-5	2005	Expression of mutagenized UGT1A1 plasmids showed that substitution of any of the seven cysteine residues located within the endoplasmic reticulum cisternae (including those mutated in patients A and B) abolished UGT1A1 activity or markedly increased its apparent K(m) for bilirubin.	Bilirubin	272-281	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	212-218
16316349-1	2005	BACKGROUND: The heme oxygenase system (HO-1 and HO-2) catalyzes the conversion of heme to free iron, carbon monoxide (CO), a vasodepressor, and biliverdin, which is further converted to bilirubin, an antioxidant.	Bilirubin	186-195	heme oxygenase 1	Rattus norvegicus	39-43
16155084-3	2005	HO-1 catabolizes heme into biliverdin (BV), which is rapidly converted to bilirubin by BV reductase.	Bilirubin	74-83	heme oxygenase 1	Rattus norvegicus	0-4
16300751-6	2005	MDA, CD, GSH, beta-carotene, ALT, AST and total and direct bilirubin levels of the patients with CVHB returned approximately to normal levels 6 months after treatment with IFN-alpha.	Bilirubin	59-68	interferon alpha 1	Homo sapiens	172-181
16373841-0	2005	Mechanisms of heme oxygenase-1-mediated cardiac and pulmonary vascular protection in chronic hypoxia: roles of carbon monoxide and bilirubin.	Bilirubin	131-140	heme oxygenase 1	Homo sapiens	14-30
16234431-12	2005	Moreover, serum levels of bilirubin, a metabolite of HO-1, were elevated in rheumatoid arthritis patients without bone damage, suggesting HO-1 affects bone loss in humans.	Bilirubin	26-35	heme oxygenase 1	Homo sapiens	53-57
16234431-12	2005	Moreover, serum levels of bilirubin, a metabolite of HO-1, were elevated in rheumatoid arthritis patients without bone damage, suggesting HO-1 affects bone loss in humans.	Bilirubin	26-35	heme oxygenase 1	Homo sapiens	138-142
16316349-1	2005	BACKGROUND: The heme oxygenase system (HO-1 and HO-2) catalyzes the conversion of heme to free iron, carbon monoxide (CO), a vasodepressor, and biliverdin, which is further converted to bilirubin, an antioxidant.	Bilirubin	186-195	heme oxygenase 2	Rattus norvegicus	48-52
16129699-4	2005	Furthermore, NOS2 protein expression and activity were reduced in murine macrophages stimulated with LPS and preincubated with bilirubin at concentrations similar to that found in the serum of hyperbilirubinemic animals.	Bilirubin	127-136	nitric oxide synthase 2, inducible	Mus musculus	13-17
16183037-0	2005	Evidence for induced microsomal bilirubin degradation by cytochrome P450 2A5.	Bilirubin	32-41	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	57-76
16183037-3	2005	In this paper, we present evidence for a major role of the hepatic cytochrome P450 2A5 (Cyp2a5) in BR degradation during cadmium intoxication, where the BR levels are elevated following induction of haem oxygenase-1 (HO-1).	Bilirubin	99-101	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	67-86
16183037-3	2005	In this paper, we present evidence for a major role of the hepatic cytochrome P450 2A5 (Cyp2a5) in BR degradation during cadmium intoxication, where the BR levels are elevated following induction of haem oxygenase-1 (HO-1).	Bilirubin	99-101	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	88-94
16183037-3	2005	In this paper, we present evidence for a major role of the hepatic cytochrome P450 2A5 (Cyp2a5) in BR degradation during cadmium intoxication, where the BR levels are elevated following induction of haem oxygenase-1 (HO-1).	Bilirubin	153-155	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	67-86
16183037-3	2005	In this paper, we present evidence for a major role of the hepatic cytochrome P450 2A5 (Cyp2a5) in BR degradation during cadmium intoxication, where the BR levels are elevated following induction of haem oxygenase-1 (HO-1).	Bilirubin	153-155	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	88-94
16183037-3	2005	In this paper, we present evidence for a major role of the hepatic cytochrome P450 2A5 (Cyp2a5) in BR degradation during cadmium intoxication, where the BR levels are elevated following induction of haem oxygenase-1 (HO-1).	Bilirubin	153-155	heme oxygenase 1	Mus musculus	217-221
16183037-8	2005	BR totally inhibited the microsomal Cyp2a5-dependent coumarin hydroxylase activity, with an IC(50) approximately equal to the substrate concentration.	Bilirubin	0-2	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	36-42
16183037-10	2005	The microsomal BR degradation was inhibited by coumarin and a monoclonal antibody against the Cyp2a5 by about 90%.	Bilirubin	15-17	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	94-100
16183037-13	2005	Secondly, the coordinated up-regulation of the HO-1 and Cyp2a5 during Cd-mediated injury implicates a network of enzyme systems in the maintenance of balancing BR production and elimination.	Bilirubin	160-162	heme oxygenase 1	Mus musculus	47-51
16183037-13	2005	Secondly, the coordinated up-regulation of the HO-1 and Cyp2a5 during Cd-mediated injury implicates a network of enzyme systems in the maintenance of balancing BR production and elimination.	Bilirubin	160-162	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	56-62
16287987-1	2005	Biliverdin reductase (BVR) functions in cell signaling through three distinct tracks: a dual-specificity kinase that functions in the insulin receptor/MAPK pathways (25, 29, 51); a bzip-type transcription factor for ATF-2/CREB and HO-1 regulation (1, 25); and a reductase that catalyzes the conversion of biliverdin to bilirubin (27).	Bilirubin	319-328	biliverdin reductase A	Homo sapiens	0-20
16287987-1	2005	Biliverdin reductase (BVR) functions in cell signaling through three distinct tracks: a dual-specificity kinase that functions in the insulin receptor/MAPK pathways (25, 29, 51); a bzip-type transcription factor for ATF-2/CREB and HO-1 regulation (1, 25); and a reductase that catalyzes the conversion of biliverdin to bilirubin (27).	Bilirubin	319-328	biliverdin reductase A	Homo sapiens	22-25
16344598-8	2005	CO also stimulates mrp2-dependent excretion of bilirubin-IXalpha and helps heme catabolism.	Bilirubin	47-56	ATP binding cassette subfamily C member 2	Homo sapiens	19-23
16129699-0	2005	Bilirubin decreases nos2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in rats.	Bilirubin	0-9	nitric oxide synthase 2	Rattus norvegicus	20-24
16211250-9	2005	The serum-conjugated bilirubin level in EHBRs decreased to a normal level (35.7 to 6.4 micromol/l) with the expression of human MRP2.	Bilirubin	21-30	ATP binding cassette subfamily C member 2	Homo sapiens	128-132
16118329-6	2005	By analysis of the double-reciprocal plots of bilirubin glucuronidation activities at different bilirubin concentrations in the presence of fixed concentrations of inhibitors, the UGT1A1 inhibition by atazanavir and indinavir was demonstrated to follow a linear mixed-type inhibition mechanism (Ki = 1.9 and 47.9 microM, respectively).	Bilirubin	46-55	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	180-186
16118329-6	2005	By analysis of the double-reciprocal plots of bilirubin glucuronidation activities at different bilirubin concentrations in the presence of fixed concentrations of inhibitors, the UGT1A1 inhibition by atazanavir and indinavir was demonstrated to follow a linear mixed-type inhibition mechanism (Ki = 1.9 and 47.9 microM, respectively).	Bilirubin	96-105	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	180-186
16118329-7	2005	These results suggest that a direct inhibition of UGT1A1-mediated bilirubin glucuronidation may provide a mechanism for the reversible hyperbilirubinemia associated with administration of atazanavir as well as indinavir.	Bilirubin	66-75	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	50-56
16019265-2	2005	A single injection of pDNA expressing hUGT1A1 under the CMV promoter resulted in excretion of bilirubin glucuronides in bile and a significant decrease in serum bilirubin for at least 2 or 4 weeks, respectively.	Bilirubin	94-103	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	38-45
16019265-2	2005	A single injection of pDNA expressing hUGT1A1 under the CMV promoter resulted in excretion of bilirubin glucuronides in bile and a significant decrease in serum bilirubin for at least 2 or 4 weeks, respectively.	Bilirubin	161-170	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	38-45
16081167-8	2005	Significant correlation was demonstrated between both TGF-beta1 and ALT or AST as well as between TIMP-1 and ALT, AST or bilirubin.	Bilirubin	121-130	TIMP metallopeptidase inhibitor 1	Homo sapiens	98-104
16139098-5	2005	Co-incubation with bilirubin or 3"-azido-3"-deoxythymidine (UGT1A1 and 2B7 inhibitors, respectively) inhibited the greatest amount of ethyl glucuronide formation, though other UGT inhibitors also showed some effect.	Bilirubin	19-28	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	60-74
16139098-5	2005	Co-incubation with bilirubin or 3"-azido-3"-deoxythymidine (UGT1A1 and 2B7 inhibitors, respectively) inhibited the greatest amount of ethyl glucuronide formation, though other UGT inhibitors also showed some effect.	Bilirubin	19-28	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	60-63
15901614-4	2005	The protective effects of heme oxygenase-1 and products of its enzymatic activity, including carbon monoxide, biliverdin and bilirubin, and ferritin, have opened the door to potential therapeutic and disease-monitoring possibilities that one day may be applicable to pulmonary medicine.	Bilirubin	125-134	heme oxygenase 1	Homo sapiens	26-42
16198234-2	2005	Heme oxygenase-1 (HO-1), implicated in a role in NO resistance, might confer its protective effect through the direct products biliverdin and CO or the secondary product bilirubin.	Bilirubin	170-179	heme oxygenase 1	Homo sapiens	0-16
16198234-2	2005	Heme oxygenase-1 (HO-1), implicated in a role in NO resistance, might confer its protective effect through the direct products biliverdin and CO or the secondary product bilirubin.	Bilirubin	170-179	heme oxygenase 1	Homo sapiens	18-22
15923095-2	2005	d-GalN/LPS (300 mg/kg body weight/30 microg/kg body weight)-induced hepatic damage was manifested by a significant increase in the activities of marker enzymes (aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and gamma glutamyl transferase) and bilirubin level in serum and lipids both in serum and liver.	Bilirubin	287-296	galanin and GMAP prepropeptide	Rattus norvegicus	2-6
16309585-2	2005	HO-1 catalyzes the conversion of heme into carbon monoxide (CO), iron, and biliverdin, which is subsequently converted to bilirubin.	Bilirubin	122-131	heme oxygenase 1	Homo sapiens	0-4
16309585-3	2005	The beneficial effects of HO-1 induction include decreasing pro-oxidants (heme), increasing anti-oxidants (biliverdin and bilirubin), and producing a vasodilator with anti-apoptotic and anti-inflammatory properties (CO).	Bilirubin	122-131	heme oxygenase 1	Homo sapiens	26-30
16309585-9	2005	Bilirubin, a product of the heme oxygenase reaction, attenuates TGF-beta1-mediated increases in fibronectin expression.	Bilirubin	0-9	transforming growth factor beta 1	Homo sapiens	64-73
16309585-9	2005	Bilirubin, a product of the heme oxygenase reaction, attenuates TGF-beta1-mediated increases in fibronectin expression.	Bilirubin	0-9	fibronectin 1	Homo sapiens	96-107
16237771-7	2005	The bilirubin levels for the cholelithiasis patients with the homozygous variant-UGT1A1 gene were significantly different from the control analog (18.0+/-6.5 and 12.7+/-2.9 micromol/L, respectively; P&lt;0.001, Student"s t test).	Bilirubin	4-13	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	81-87
16249618-2	2005	Heme oxygenase-1 (HO-1) catalyzes heme breakdown, eventually generating bilirubin, iron and carbon monoxide.	Bilirubin	72-81	heme oxygenase 1	Homo sapiens	0-16
16249618-2	2005	Heme oxygenase-1 (HO-1) catalyzes heme breakdown, eventually generating bilirubin, iron and carbon monoxide.	Bilirubin	72-81	heme oxygenase 1	Homo sapiens	18-22
16020746-6	2005	The proposed mechanisms by which HO-1 exerts its cytoprotective effects include its abilities to degrade the pro-oxidative heme, to release biliverdin and subsequently convert it bilirubin, both of which have antioxidant properties, and to generate carbon monoxide, which has antiproliferative and antiinflammatory as well as vasodilatory properties.	Bilirubin	179-188	heme oxygenase 1	Homo sapiens	33-37
15965653-6	2005	In another 39 patients, the correlation of the MRP2 expression of the anticipated remnant liver with the posthepatectomy severe hyperbilirubinemia, defined as a serum total bilirubin concentration&gt;or=200 micromol/l, was evaluated.	Bilirubin	133-142	ATP binding cassette subfamily C member 2	Homo sapiens	47-51
16020495-2	2005	Heme oxygenase 1 (HO-1) is involved in the generation of the endogenous antioxidant bilirubin and carbon monoxide, both of which exert antiinflammatory and antiproliferative effects.	Bilirubin	84-93	heme oxygenase 1	Homo sapiens	0-16
16020495-2	2005	Heme oxygenase 1 (HO-1) is involved in the generation of the endogenous antioxidant bilirubin and carbon monoxide, both of which exert antiinflammatory and antiproliferative effects.	Bilirubin	84-93	heme oxygenase 1	Homo sapiens	18-22
15965653-9	2005	Postoperative maximum bilirubin levels were significantly correlated with MRP2 expression of the anticipated remnant liver.	Bilirubin	22-31	ATP binding cassette subfamily C member 2	Homo sapiens	74-78
16117883-1	2005	BACKGROUND: Heme-oxygenase 1 (HO-1) is a rate-limiting enzyme in the degradation of heme to bilirubin, ferritin and carbon monoxide (CO) and may have significant anti-inflammatory function.	Bilirubin	92-101	heme oxygenase 1	Homo sapiens	12-28
16146339-5	2005	The antioxidant effect of L-methionine was mimicked by the HO-1 product bilirubin, which suppressed free radical formation almost completely.	Bilirubin	72-81	heme oxygenase 1	Homo sapiens	59-63
16087796-2	2005	On the basis of observations that oxidative stress is a potent trigger in vascular proliferative responses, that heme oxygenase-1 is antiatherogenic, and that several studies now show that individuals with high-normal or supranormal levels of plasma bilirubin have a lesser incidence of atherosclerosis-related diseases, we hypothesized that bilirubin would have salutary effects on preventing intimal hyperplasia after balloon injury.	Bilirubin	250-259	heme oxygenase 1	Rattus norvegicus	113-129
16117883-1	2005	BACKGROUND: Heme-oxygenase 1 (HO-1) is a rate-limiting enzyme in the degradation of heme to bilirubin, ferritin and carbon monoxide (CO) and may have significant anti-inflammatory function.	Bilirubin	92-101	heme oxygenase 1	Homo sapiens	30-34
16004608-1	2005	PURPOSE: Homozygosity for the (AT)7 allele of uridine diphosphate glucuronosyl transferase 1A (UGT1A1) gene polymorphism is associated with increased bilirubin levels in sickle cell anemia (SCA).	Bilirubin	150-159	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	95-101
15821039-8	2005	These data demonstrate that an increase in HO-1 protein and activity, i.e., CO and bilirubin production, in diabetic rats brings about a robust increase in EC-SOD, catalase, and eNOS with a concomitant increase in endothelial relaxation and a decrease in O2-.	Bilirubin	83-92	heme oxygenase 1	Rattus norvegicus	43-47
15821039-8	2005	These data demonstrate that an increase in HO-1 protein and activity, i.e., CO and bilirubin production, in diabetic rats brings about a robust increase in EC-SOD, catalase, and eNOS with a concomitant increase in endothelial relaxation and a decrease in O2-.	Bilirubin	83-92	superoxide dismutase 3	Rattus norvegicus	156-162
15821039-8	2005	These data demonstrate that an increase in HO-1 protein and activity, i.e., CO and bilirubin production, in diabetic rats brings about a robust increase in EC-SOD, catalase, and eNOS with a concomitant increase in endothelial relaxation and a decrease in O2-.	Bilirubin	83-92	catalase	Rattus norvegicus	164-172
16004608-13	2005	CONCLUSIONS: Apart from UGT1A1 (AT)7 homozygosity, Hb F, age and gender are the other factors that significantly influence serum bilirubin level in SCA.	Bilirubin	129-138	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	24-30
15986396-8	2005	Using an heterologous expression system, the bilirubin-conjugating UGT1A1 enzyme was identified among all known UGTs (n = 16) as the predominant enzyme involved.	Bilirubin	45-54	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	67-73
15986414-0	2005	CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice.	Bilirubin	53-62	nuclear receptor subfamily 1, group I, member 3	Mus musculus	0-3
16025517-1	2005	Crigler-Najjar type 1 disease (CN1) is a rare inherited metabolic disease characterized by complete absence of hepatic UDP-glucuronosyl transferase (UGT1), resulting in high levels of unconjugated bilirubin.	Bilirubin	197-206	UDP glycosyltransferase 1 family, polypeptide A4, pseudogene	Rattus norvegicus	149-153
15986414-0	2005	CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice.	Bilirubin	53-62	nuclear receptor subfamily 1, group I, member 2	Mus musculus	8-11
15986414-8	2005	In addition, CAR agonists upregulated bile acid-sulfating Sult2a1 and bilirubin-glucuronidating Ugt1a1.	Bilirubin	70-79	nuclear receptor subfamily 1, group I, member 3	Mus musculus	13-16
16076256-0	2005	Single hepatic venous injection of liver-specific naked plasmid vector expressing human UGT1A1 leads to long-term correction of hyperbilirubinemia and prevention of chronic bilirubin toxicity in Gunn rats.	Bilirubin	133-142	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	88-94
15986414-8	2005	In addition, CAR agonists upregulated bile acid-sulfating Sult2a1 and bilirubin-glucuronidating Ugt1a1.	Bilirubin	70-79	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	96-102
15986414-11	2005	In conclusion, administration of specific CAR or PXR ligands results in coordinated stimulation of major hepatic bile acid/bilirubin metabolizing and detoxifying enzymes and hepatic key alternative efflux systems, effects that are predicted to counteract cholestasis.	Bilirubin	123-132	nuclear receptor subfamily 1, group I, member 3	Mus musculus	42-45
16076256-3	2005	Although repeat injections of pcDNA3hUGT1A1 consistently reduced serum bilirubin levels, the effect did not exceed 2 weeks; hUGT1A1 was detectable in livers only for 2 weeks, despite the presence of vector and transcript for at least 1 month.	Bilirubin	71-80	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	36-43
15986414-11	2005	In conclusion, administration of specific CAR or PXR ligands results in coordinated stimulation of major hepatic bile acid/bilirubin metabolizing and detoxifying enzymes and hepatic key alternative efflux systems, effects that are predicted to counteract cholestasis.	Bilirubin	123-132	nuclear receptor subfamily 1, group I, member 2	Mus musculus	49-52
16080518-0	2005	Involvement of ABC transporters in chemosensitivity of human renal cell carcinoma, and regulation of MRP2 expression by conjugated bilirubin.	Bilirubin	131-140	ATP binding cassette subfamily C member 2	Homo sapiens	101-105
16132704-3	2005	Inhibition of several secretory phospholipase A(2) (sPLA(2)) enzyme activities by bilirubin was studied using (14)C-oleate labeled Escherichia coli as substrate.	Bilirubin	82-91	phospholipase A2 group X	Homo sapiens	52-59
16132704-4	2005	Bilirubin inhibits purified sPLA(2) enzyme from Vipera russellii and Naja naja venom and partially purified sPLA(2) enzymes from human ascitic fluid, pleural fluid and normal serum in a dose dependent manner.	Bilirubin	0-9	phospholipase A2 group X	Homo sapiens	28-35
16132704-4	2005	Bilirubin inhibits purified sPLA(2) enzyme from Vipera russellii and Naja naja venom and partially purified sPLA(2) enzymes from human ascitic fluid, pleural fluid and normal serum in a dose dependent manner.	Bilirubin	0-9	phospholipase A2 group X	Homo sapiens	108-115
16132704-6	2005	Inflammatory human sPLA(2) enzymes are more sensitive to inhibition by bilirubin than snake venom sPLA(2)s.	Bilirubin	71-80	phospholipase A2 group X	Homo sapiens	19-26
16132704-7	2005	Inhibition of sPLA(2) activity by bilirubin is independent of calcium concentration.	Bilirubin	34-43	phospholipase A2 group X	Homo sapiens	14-21
16132704-9	2005	Bilirubin quenched the relative fluorescence intensity of sPLA(2) in a dose dependent manner in the same concentration range at which in vitro sPLA(2) inhibition was observed.	Bilirubin	0-9	phospholipase A2 group X	Homo sapiens	58-65
16132704-9	2005	Bilirubin quenched the relative fluorescence intensity of sPLA(2) in a dose dependent manner in the same concentration range at which in vitro sPLA(2) inhibition was observed.	Bilirubin	0-9	phospholipase A2 group X	Homo sapiens	143-150
16132704-10	2005	In the presence of bilirubin, apparent shift in the far UV-CD spectra of sPLA(2) was observed, indicating a direct interaction with the enzyme.	Bilirubin	19-28	phospholipase A2 group X	Homo sapiens	73-80
16132704-11	2005	Inhibition of sPLA(2) induced mouse paw edema by bilirubin confirms its sPLA(2) inhibitory activity in vivo also.	Bilirubin	49-58	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	14-21
16132704-11	2005	Inhibition of sPLA(2) induced mouse paw edema by bilirubin confirms its sPLA(2) inhibitory activity in vivo also.	Bilirubin	49-58	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	72-79
16132704-12	2005	These findings indicate that inhibition of sPLA(2) by bilirubin is mediated by direct interaction with the enzyme and bilirubin may act as an endogenous regulator of sPLA(2) enzyme activity.	Bilirubin	54-63	phospholipase A2 group X	Homo sapiens	43-50
16132704-12	2005	These findings indicate that inhibition of sPLA(2) by bilirubin is mediated by direct interaction with the enzyme and bilirubin may act as an endogenous regulator of sPLA(2) enzyme activity.	Bilirubin	118-127	phospholipase A2 group X	Homo sapiens	43-50
16132704-12	2005	These findings indicate that inhibition of sPLA(2) by bilirubin is mediated by direct interaction with the enzyme and bilirubin may act as an endogenous regulator of sPLA(2) enzyme activity.	Bilirubin	118-127	phospholipase A2 group X	Homo sapiens	166-173
16061593-2	2005	This study tested the hypotheses that feeding breastfed newborns beta-glucuronidase inhibitors during the first week after birth would increase fecal bilirubin excretion and would reduce jaundice without affecting breastfeeding deleteriously.	Bilirubin	150-159	glucuronidase beta	Homo sapiens	65-83
16061593-13	2005	CONCLUSIONS: Use of minimal aliquots of L-aspartic acid and EHC for beta-glucuronidase inhibition results in increased fecal bilirubin excretion and less jaundice, without disruption of the breastfeeding experience.	Bilirubin	125-134	glucuronidase beta	Homo sapiens	68-86
16080518-5	2005	MRP2 mRNA expression in renal carcinoma was significantly increased when cells were cultured in the presence of conjugated bilirubin.	Bilirubin	123-132	ATP binding cassette subfamily C member 2	Homo sapiens	0-4
16080518-6	2005	In an established renal proximal tubule epithelial cell line (RPTEC), conjugated bilirubin increased MRP2 expression at the mRNA and protein levels, and decreased the cisplatin sensitivity of the cells.	Bilirubin	81-90	ATP binding cassette subfamily C member 2	Homo sapiens	101-105
16080518-7	2005	These results indicate that MRP2 expression in renal cell carcinoma may be regulated by conjugated bilirubin in the body and decreased during in vitro culture.	Bilirubin	99-108	ATP binding cassette subfamily C member 2	Homo sapiens	28-32
16029192-4	2005	Moreover, minocycline inhibits the bilirubin-induced phosphorylation of p38 mitogen-activated protein kinase both in vivo as well as in vitro.	Bilirubin	35-44	mitogen activated protein kinase 14	Rattus norvegicus	72-75
15880142-1	2005	The enzyme heme oxygenase-1 (HO-1) is a cytoprotective and anti-inflammatory protein that degrades heme to produce biliverdin/bilirubin, ferrous iron and carbon monoxide (CO).	Bilirubin	126-135	heme oxygenase 1	Mus musculus	11-27
15880142-1	2005	The enzyme heme oxygenase-1 (HO-1) is a cytoprotective and anti-inflammatory protein that degrades heme to produce biliverdin/bilirubin, ferrous iron and carbon monoxide (CO).	Bilirubin	126-135	heme oxygenase 1	Mus musculus	29-33
16012956-1	2005	BACKGROUND &amp; AIMS: Dubin-Johnson syndrome is recessively inherited, conjugated hyperbilirubinemia induced by mutations in the ABCC2/MRP2 gene encoding the canalicular transporter for conjugated bilirubin.	Bilirubin	88-97	ATP binding cassette subfamily C member 2	Homo sapiens	130-135
16012956-1	2005	BACKGROUND &amp; AIMS: Dubin-Johnson syndrome is recessively inherited, conjugated hyperbilirubinemia induced by mutations in the ABCC2/MRP2 gene encoding the canalicular transporter for conjugated bilirubin.	Bilirubin	88-97	ATP binding cassette subfamily C member 2	Homo sapiens	136-140
16012956-2	2005	Gilbert"s syndrome is recessively inherited, unconjugated hyperbilirubinemia caused by decreased conjugation rate of bilirubin associated mostly with homozygous A(TA) 7 TAA variant of the TATAA-box in the UGT1A1 gene promoter.	Bilirubin	63-72	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	205-211
15814571-6	2005	After induction of cholestasis by bile duct ligation, Mrp3(-/-) mice had 1.5-fold higher levels of liver bile acids and 3.1-fold lower levels of serum bilirubin glucuronide compared with ligated wild-type mice, whereas significant differences were not observed between the respective sham-operated mice.	Bilirubin	151-160	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	54-58
15962316-8	2005	A20 expression in the liver limits hepatocellular damage hence maintains bilirubin clearance and the liver synthetic function.	Bilirubin	73-82	tumor necrosis factor, alpha-induced protein 3	Mus musculus	0-3
15978035-1	2005	Bilitranslocase is a rat liver plasma membrane carrier, displaying a high-affinity binding site for bilirubin.	Bilirubin	100-109	ceruloplasmin	Rattus norvegicus	0-15
15978035-7	2005	In analogy to liver bilitranslocase, one antibody identified a bilirubin-binding site (Kd = 1.7 nm) in the carnation carrier.	Bilirubin	63-72	ceruloplasmin	Rattus norvegicus	20-35
15890016-1	2005	Heme oxygenase isoforms (HO-1/HO-2) catalyze the conversion of heme to carbon monoxide (CO) and bilirubin.	Bilirubin	96-105	heme oxygenase 1	Homo sapiens	0-34
15921999-2	2005	Three substrates were chosen to cover both UGT1A and UGT2B family isozymes: bilirubin (substrate of UGT1A1), p-nitrophenol (UGT1A6) and ethinylestradiol (UGT2B1 and 2B3 for position C17 and UGT1A1 for position C3).	Bilirubin	76-85	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	100-106
15896810-13	2005	Among the various HSPs, HSP32, also known as heme oxygenase I (HO-1), has received considerable attention, as it has been recently demonstrated that HO-1 induction, by generating the vasoactive molecule carbon monoxide and the potent antioxidant bilirubin, could represent a protective system potentially active against brain oxidative injury.	Bilirubin	246-255	heme oxygenase 1	Homo sapiens	24-29
15896810-13	2005	Among the various HSPs, HSP32, also known as heme oxygenase I (HO-1), has received considerable attention, as it has been recently demonstrated that HO-1 induction, by generating the vasoactive molecule carbon monoxide and the potent antioxidant bilirubin, could represent a protective system potentially active against brain oxidative injury.	Bilirubin	246-255	heme oxygenase 1	Homo sapiens	63-67
15896810-13	2005	Among the various HSPs, HSP32, also known as heme oxygenase I (HO-1), has received considerable attention, as it has been recently demonstrated that HO-1 induction, by generating the vasoactive molecule carbon monoxide and the potent antioxidant bilirubin, could represent a protective system potentially active against brain oxidative injury.	Bilirubin	246-255	heme oxygenase 1	Homo sapiens	149-153
15911218-7	2005	When added exogenously to the cells at low micromolar concentrations, the HO-1 metabolite, bilirubin, virtually abolished NADPH-dependent oxidative stress.	Bilirubin	91-100	heme oxygenase 1	Homo sapiens	74-78
16044631-5	2005	In particular, heme oxygenase-1 (HO-1), the enzyme involved in heme protein metabolism, can provide antioxidant protection through the production of the antioxidant bilirubin.	Bilirubin	165-174	heme oxygenase 1	Homo sapiens	15-31
16044631-5	2005	In particular, heme oxygenase-1 (HO-1), the enzyme involved in heme protein metabolism, can provide antioxidant protection through the production of the antioxidant bilirubin.	Bilirubin	165-174	heme oxygenase 1	Homo sapiens	33-37
16045031-6	2005	There were linear correlations between the PAF and LPS level, the total bilirubin level and PAF level, the PAF level and serum creatinine level.	Bilirubin	72-81	PCNA clamp associated factor	Homo sapiens	92-95
16045031-6	2005	There were linear correlations between the PAF and LPS level, the total bilirubin level and PAF level, the PAF level and serum creatinine level.	Bilirubin	72-81	PCNA clamp associated factor	Homo sapiens	92-95
15988124-4	2005	The TA-1801A glucuronosyltransferase activity in human liver microsomes was inhibited by bilirubin (typical substrate for UGT1A1), propofol (typical substrate for UGT1A9), diclofenac (substrate for UGT1A9 and UGT2B7), and genistein (substrate for UGT1A1, UGT1A3, and UGT1A9).	Bilirubin	89-98	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	122-128
15988124-4	2005	The TA-1801A glucuronosyltransferase activity in human liver microsomes was inhibited by bilirubin (typical substrate for UGT1A1), propofol (typical substrate for UGT1A9), diclofenac (substrate for UGT1A9 and UGT2B7), and genistein (substrate for UGT1A1, UGT1A3, and UGT1A9).	Bilirubin	89-98	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	198-204
15988124-4	2005	The TA-1801A glucuronosyltransferase activity in human liver microsomes was inhibited by bilirubin (typical substrate for UGT1A1), propofol (typical substrate for UGT1A9), diclofenac (substrate for UGT1A9 and UGT2B7), and genistein (substrate for UGT1A1, UGT1A3, and UGT1A9).	Bilirubin	89-98	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	209-215
15988124-4	2005	The TA-1801A glucuronosyltransferase activity in human liver microsomes was inhibited by bilirubin (typical substrate for UGT1A1), propofol (typical substrate for UGT1A9), diclofenac (substrate for UGT1A9 and UGT2B7), and genistein (substrate for UGT1A1, UGT1A3, and UGT1A9).	Bilirubin	89-98	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	247-253
15988124-4	2005	The TA-1801A glucuronosyltransferase activity in human liver microsomes was inhibited by bilirubin (typical substrate for UGT1A1), propofol (typical substrate for UGT1A9), diclofenac (substrate for UGT1A9 and UGT2B7), and genistein (substrate for UGT1A1, UGT1A3, and UGT1A9).	Bilirubin	89-98	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	255-261
15988124-4	2005	The TA-1801A glucuronosyltransferase activity in human liver microsomes was inhibited by bilirubin (typical substrate for UGT1A1), propofol (typical substrate for UGT1A9), diclofenac (substrate for UGT1A9 and UGT2B7), and genistein (substrate for UGT1A1, UGT1A3, and UGT1A9).	Bilirubin	89-98	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	198-204
15988124-5	2005	The inhibition by bilirubin, propofol, and diclofenac of the TA-1801A glucuronidation was less pronounced in jejunum microsomes than liver microsomes, suggesting that the contribution of UGT1A1, UGT1A9, and UGT2B7 to the TA-1801A glucuronidation is smaller in the intestine than the liver.	Bilirubin	18-27	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	187-193
15988124-5	2005	The inhibition by bilirubin, propofol, and diclofenac of the TA-1801A glucuronidation was less pronounced in jejunum microsomes than liver microsomes, suggesting that the contribution of UGT1A1, UGT1A9, and UGT2B7 to the TA-1801A glucuronidation is smaller in the intestine than the liver.	Bilirubin	18-27	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	195-201
15988124-5	2005	The inhibition by bilirubin, propofol, and diclofenac of the TA-1801A glucuronidation was less pronounced in jejunum microsomes than liver microsomes, suggesting that the contribution of UGT1A1, UGT1A9, and UGT2B7 to the TA-1801A glucuronidation is smaller in the intestine than the liver.	Bilirubin	18-27	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	207-213
15827452-3	2005	Extracorporeal albumin dialysis (molecular adsorbent recycling system, MARS) is a novel treatment which removes albumin bound toxins including bilirubin and bile salts.	Bilirubin	143-152	methionyl-tRNA synthetase 1	Homo sapiens	71-75
15820482-1	2005	BACKGROUND: Albumin is a potent antioxidant as it chelates transitional metals and contains antioxidants like thiol and bilirubin.	Bilirubin	120-129	albumin	Homo sapiens	12-19
15867280-0	2005	Cruciferae interact with the UGT1A1*28 polymorphism to determine serum bilirubin levels in humans.	Bilirubin	71-80	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	29-35
15867280-1	2005	UDP-glucuronosyltransferase (UGT) 1A1 is a conjugating biotransformation enzyme that plays a role in maintaining levels of endogenous compounds (e.g., bilirubin) and handling exogenous compounds, including carcinogens.	Bilirubin	151-160	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-37
15867280-8	2005	There was a significant inverse association between all 3 bilirubin measures and interaction of UGT1A1*28 genotype with Cruciferae intake (P &lt; 0.02 for each measure); individuals with the 7/7 genotype had reduced bilirubin concentrations with increased intake of cruciferous vegetables, whereas individuals with the 6/6 or 6/7 genotype did not.	Bilirubin	216-225	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	96-102
15741166-1	2005	BVR reduces biliverdin, the HO-1 and HO-2 product, to bilirubin.	Bilirubin	54-63	biliverdin reductase A	Homo sapiens	0-3
15953334-2	2005	A Chinese girl with severe jaundice was recently diagnosed to have CN syndrome type I by analyzing the bilirubin-uridinediphospho (UDP)-glucuronosyltransferase gene (UGT1A1).	Bilirubin	103-112	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	166-172
15716465-1	2005	UDP glucuronosyltransferases (UGT) detoxify bilirubin and therapeutic drugs, a process influenced by single nucleotide polymorphisms (SNPs) in their structural genes and promoter elements.	Bilirubin	44-53	beta-1,3-glucuronyltransferase 2	Homo sapiens	0-28
15716465-1	2005	UDP glucuronosyltransferases (UGT) detoxify bilirubin and therapeutic drugs, a process influenced by single nucleotide polymorphisms (SNPs) in their structural genes and promoter elements.	Bilirubin	44-53	beta-1,3-glucuronyltransferase 2	Homo sapiens	30-33
15901347-0	2005	Modulation of intestinal transport of 2,4-dinitrophenyl-S-glutathione, a multidrug resistance-associated protein 2 substrate, by bilirubin treatment in rats.	Bilirubin	129-138	ATP binding cassette subfamily C member 2	Rattus norvegicus	73-114
15901347-1	2005	The effect of bilirubin treatment on intestinal transport of 2,4-dinitrophenyl-S-glutathione (DNP-SG), a substrate of multidrug resistance-associated protein 2 (MRP2), after application of 1-chloro-2, 4-dinitrobenzene (CDNB), a precursor of DNP-SG, was examined in rat intestine by the in-vitro everted sac, in-situ re-circulating perfusion, and in-situ loop methods.	Bilirubin	14-23	ATP binding cassette subfamily C member 2	Rattus norvegicus	118-159
15901347-1	2005	The effect of bilirubin treatment on intestinal transport of 2,4-dinitrophenyl-S-glutathione (DNP-SG), a substrate of multidrug resistance-associated protein 2 (MRP2), after application of 1-chloro-2, 4-dinitrobenzene (CDNB), a precursor of DNP-SG, was examined in rat intestine by the in-vitro everted sac, in-situ re-circulating perfusion, and in-situ loop methods.	Bilirubin	14-23	ATP binding cassette subfamily C member 2	Rattus norvegicus	161-165
15919451-8	2005	Significant correlation to the blood level of bilirubin and liver enzymes confirmed the presumed hepatotoxic potential of CsA and some metabolites.	Bilirubin	46-55	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	122-125
15741166-1	2005	BVR reduces biliverdin, the HO-1 and HO-2 product, to bilirubin.	Bilirubin	54-63	biliverdin reductase A	Homo sapiens	12-22
15751016-0	2005	Heme oxygenase-1 activity after excitotoxic injury: immunohistochemical localization of bilirubin in neurons and astrocytes and deleterious effects of heme oxygenase inhibition on neuronal survival after kainate treatment.	Bilirubin	88-97	heme oxygenase 1	Rattus norvegicus	0-16
15795103-4	2005	MRP2 also handles endogenous molecules such as bilirubin, and its overexpression has been shown to confer a multidrug resistance phenotype to tumoral cells.	Bilirubin	47-56	ATP binding cassette subfamily C member 2	Homo sapiens	0-4
15561977-2	2005	HO-1 degrades heme into carbon monoxide (CO) and biliverdin; the latter is then converted to bilirubin.	Bilirubin	93-102	heme oxygenase 1	Rattus norvegicus	0-4
15561977-4	2005	Manipulation of the HO-1 system by administration of micromolar doses of exogenous CO or bilirubin has been performed in several organ systems, but the dose-related effects of these reaction products have not been investigated in the kidney.	Bilirubin	89-98	heme oxygenase 1	Rattus norvegicus	20-24
15561977-9	2005	We conclude that the protective effects of HO-1 activity during IRI in the kidney are mediated, at least in part, by bilirubin and that pretreatment with micromolar doses of bilirubin may offer a simple and inexpensive method to improve renal function after IRI.	Bilirubin	117-126	heme oxygenase 1	Rattus norvegicus	43-47
15561977-9	2005	We conclude that the protective effects of HO-1 activity during IRI in the kidney are mediated, at least in part, by bilirubin and that pretreatment with micromolar doses of bilirubin may offer a simple and inexpensive method to improve renal function after IRI.	Bilirubin	174-183	heme oxygenase 1	Rattus norvegicus	43-47
15853761-11	2005	Since UGT1A1 metabolizes not only bilirubin but also hormones and drugs, the mutations could be involved in carcinogenesis and adverse drug reactions.	Bilirubin	34-43	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	6-12
15869055-2	2005	These products have important physiologic effects: bilirubin is a potent antioxidant that can act against ischemia/reperfusion injury; there is a negative correlation between the content of HO-1 and the incidence of coronary heart disease (CHD).	Bilirubin	51-60	heme oxygenase 1	Homo sapiens	190-194
15781124-1	2005	UDP-glucuronosyltransferase (UGT) enzymes catalyze the conjugation of various endogenous substances (e.g., bilirubin) and exogenous compounds (e.g., drugs).	Bilirubin	107-116	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	0-27
16181102-11	2005	These results imply that expression of HO-1 in G0/G1 cells may be a key player in decreasing cellular heme, associated with increased generation of bilirubin, and in attenuating glucose mediated oxidative stress.	Bilirubin	148-157	heme oxygenase 1	Homo sapiens	39-43
16181103-1	2005	Heme oxygenase (HO) is a microsomal enzyme that catalyzes the degradation of heme into biliverdin, which is subsequently reduced to bilirubin, free iron and carbon monoxide (CO), and induction of heme oxygenase-1 (HO-1) is potentially associated with cellular protection, especially against oxidative insults.	Bilirubin	132-141	heme oxygenase 1	Mus musculus	196-212
15803024-2	2005	The products of heme catalysis, biliverdin/bilirubin, carbon monoxide (CO), and iron (that induces apoferritin) mediate the beneficial effects of HO-1.	Bilirubin	43-52	heme oxygenase 1	Mus musculus	146-150
15985997-4	2005	The enzyme responsible for the conjugation of bilirubin is the bilirubin uridine-diphosphate-glucuronosyltransferase (UGT).	Bilirubin	46-55	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	73-116
15985997-4	2005	The enzyme responsible for the conjugation of bilirubin is the bilirubin uridine-diphosphate-glucuronosyltransferase (UGT).	Bilirubin	46-55	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	118-121
15985997-5	2005	Mutations in the gene encoding bilirubin-UGT (UGT1A1), lead to complete or partial inactivation of the enzyme causing the rare autosomal recessively inherited conditions, Crigler-Najjar syndrome type 1 (CN-1) and type 2 (CN-2).	Bilirubin	31-40	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	41-44
15985997-5	2005	Mutations in the gene encoding bilirubin-UGT (UGT1A1), lead to complete or partial inactivation of the enzyme causing the rare autosomal recessively inherited conditions, Crigler-Najjar syndrome type 1 (CN-1) and type 2 (CN-2).	Bilirubin	31-40	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	46-52
15985997-5	2005	Mutations in the gene encoding bilirubin-UGT (UGT1A1), lead to complete or partial inactivation of the enzyme causing the rare autosomal recessively inherited conditions, Crigler-Najjar syndrome type 1 (CN-1) and type 2 (CN-2).	Bilirubin	31-40	5'-nucleotidase, cytosolic IA	Homo sapiens	203-219
15985997-5	2005	Mutations in the gene encoding bilirubin-UGT (UGT1A1), lead to complete or partial inactivation of the enzyme causing the rare autosomal recessively inherited conditions, Crigler-Najjar syndrome type 1 (CN-1) and type 2 (CN-2).	Bilirubin	31-40	carnosine dipeptidase 2	Homo sapiens	221-225
15846474-9	2005	In addition, the plasma direct bilirubin level in EHBR was reduced by the expression of human MRP2.	Bilirubin	31-40	ATP binding cassette subfamily C member 2	Homo sapiens	94-98
16181104-0	2005	Heme oxygenase-2 protects against glutathione depletion-induced neuronal apoptosis mediated by bilirubin and cyclic GMP.	Bilirubin	95-104	heme oxygenase 2	Mus musculus	0-16
16181104-3	2005	The neuroprotective effects of HO-2 have been attributed to the generation of bilirubin, which is an important radical scavenger.	Bilirubin	78-87	heme oxygenase 2	Mus musculus	31-35
16181104-8	2005	Levels of bilirubin and cGMP were also reduced in HO-2 null mice.	Bilirubin	10-19	heme oxygenase 2	Mus musculus	50-54
16181104-9	2005	Primary cultures of ORNs confirmed that the neuroprotective role of HO-2 was mediated by bilirubin and cGMP.	Bilirubin	89-98	heme oxygenase 2	Mus musculus	68-72
16181104-10	2005	Taken together, these results suggest that HO-2 plays a major role in neuroprotection from oxidative stress, an effect that is mediated by cGMP and bilirubin.	Bilirubin	148-157	heme oxygenase 2	Mus musculus	43-47
15777743-1	2005	UDP-glucuronosyltransferase1A1 (UGT1A1) catalyses glucuronidation of bilirubin (the final break down product of heme which is produced mainly in the spleen and liver) and is located on the lumen of the endoplasmic reticulum (ER).	Bilirubin	69-78	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-30
15777743-1	2005	UDP-glucuronosyltransferase1A1 (UGT1A1) catalyses glucuronidation of bilirubin (the final break down product of heme which is produced mainly in the spleen and liver) and is located on the lumen of the endoplasmic reticulum (ER).	Bilirubin	69-78	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	32-38
15781124-1	2005	UDP-glucuronosyltransferase (UGT) enzymes catalyze the conjugation of various endogenous substances (e.g., bilirubin) and exogenous compounds (e.g., drugs).	Bilirubin	107-116	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	29-32
15749910-0	2005	Unconjugated bilirubin inhibits VCAM-1-mediated transendothelial leukocyte migration.	Bilirubin	13-22	vascular cell adhesion molecule 1	Mus musculus	32-38
15696188-1	2005	Liver-type fatty acid binding protein (L-FABP) binds with high affinity to hydrophobic molecules including free fatty acid, bile acid and bilirubin, which are potentially nephrotoxic, and is involved in their metabolism mainly in hepatocytes.	Bilirubin	138-147	fatty acid binding protein 1	Rattus norvegicus	0-37
15696188-1	2005	Liver-type fatty acid binding protein (L-FABP) binds with high affinity to hydrophobic molecules including free fatty acid, bile acid and bilirubin, which are potentially nephrotoxic, and is involved in their metabolism mainly in hepatocytes.	Bilirubin	138-147	fatty acid binding protein 1	Rattus norvegicus	39-45
16851649-0	2005	Binding constant measurement by hyper-Rayleigh scattering: bilirubin-human serum albumin binding as a case study.	Bilirubin	59-68	albumin	Homo sapiens	75-88
16851649-1	2005	In this paper, a new application of the hyper-Rayleigh scattering technique in determining multiple binding constants of a small molecule like bilirubin to a macromolecule like the protein human serum albumin has been demonstrated.	Bilirubin	143-152	albumin	Homo sapiens	195-208
16851649-2	2005	Human serum albumin has two binding sites for bilirubin, and the binding constants have been measured by carrying out a second harmonic titration of the protein against bilirubin and vice versa.	Bilirubin	46-55	albumin	Homo sapiens	6-19
16851649-2	2005	Human serum albumin has two binding sites for bilirubin, and the binding constants have been measured by carrying out a second harmonic titration of the protein against bilirubin and vice versa.	Bilirubin	169-178	albumin	Homo sapiens	6-19
15749910-2	2005	Because bilirubin is a potent antioxidant, we examined the hypothesis that this bile pigment inhibits VCAM-1-dependent cellular events.	Bilirubin	8-17	vascular cell adhesion molecule 1	Mus musculus	102-108
15749910-3	2005	The migration of isolated murine splenic lymphocytes across monolayers of murine endothelial cell lines (which constitutively express VCAM-1) is significantly inhibited by physiological concentrations of bilirubin, in the absence of an effect on lymphocyte adhesion.	Bilirubin	204-213	vascular cell adhesion molecule 1	Mus musculus	134-140
15749910-4	2005	Bilirubin administration also suppresses VCAM-1-stimulated ROS generation and reduces endothelial cell matrix metalloproteinase activity.	Bilirubin	0-9	vascular cell adhesion molecule 1	Mus musculus	41-47
15749910-8	2005	CONCLUSION: bilirubin blocks VCAM-1-dependent lymphocyte migration in vitro and ameliorates VCAM-1-mediated airway inflammation in vivo, apparently through the suppression of cellular ROS production.	Bilirubin	12-21	vascular cell adhesion molecule 1	Mus musculus	29-35
15749910-8	2005	CONCLUSION: bilirubin blocks VCAM-1-dependent lymphocyte migration in vitro and ameliorates VCAM-1-mediated airway inflammation in vivo, apparently through the suppression of cellular ROS production.	Bilirubin	12-21	vascular cell adhesion molecule 1	Mus musculus	92-98
15724035-4	2005	A bilirubin production-conjugation index comprising COHbc/TCB was determined; a high index reflects imbalance between the bilirubin production and conjugation processes.	Bilirubin	2-11	pyruvate kinase M1/2	Homo sapiens	52-61
15536166-3	2005	We hypothesized that bilirubin, because of its antioxidant properties, may reduce the pressor and prooxidant effects of ANG II.	Bilirubin	21-30	angiogenin	Rattus norvegicus	120-123
15536166-9	2005	Heightened generation of superoxide anion in aortic rings in ANG II-infused rats and by vascular smooth muscle cells exposed to ANG II was normalized by bilirubin in vitro.	Bilirubin	153-162	angiotensinogen	Rattus norvegicus	61-67
15536166-9	2005	Heightened generation of superoxide anion in aortic rings in ANG II-infused rats and by vascular smooth muscle cells exposed to ANG II was normalized by bilirubin in vitro.	Bilirubin	153-162	angiotensinogen	Rattus norvegicus	128-134
15536166-10	2005	We conclude that the pressor and prooxidant effects of ANG II are attenuated in the hyperbilirubinemic Gunn rat, an effect which, we speculate, may reflect, at least in part, the scavenging of superoxide anion by bilirubin.	Bilirubin	89-98	angiotensinogen	Rattus norvegicus	55-61
15726644-6	2005	In cell cultures, ligand-free PXR specifically suppressed the ability of CAR to induce the multidrug resistance associated protein 2 (MRP2), a bilirubin-detoxifying transporter.	Bilirubin	143-152	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	134-138
15726644-0	2005	Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice.	Bilirubin	60-69	nuclear receptor subfamily 1, group I, member 2	Mus musculus	37-56
15726644-8	2005	In conclusion, PXR plays both positive and negative roles in regulating bilirubin homeostasis, and this provides a novel mechanism that may govern receptor cross-talk and the hierarchy of xenobiotic and endobiotic regulation.	Bilirubin	72-81	nuclear receptor subfamily 1, group I, member 2	Mus musculus	15-18
15726644-1	2005	The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are implicated in xenobiotic and endobiotic detoxification, including the clearance of toxic bilirubin.	Bilirubin	170-179	nuclear receptor subfamily 1, group I, member 2	Mus musculus	4-23
15726644-1	2005	The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are implicated in xenobiotic and endobiotic detoxification, including the clearance of toxic bilirubin.	Bilirubin	170-179	nuclear receptor subfamily 1, group I, member 2	Mus musculus	25-28
15726662-2	2005	In the Gunn rat model of unconjugated hyperbilirubinemia, dietary supplementation with the lipase inhibitor orlistat (Orl) or with calcium phosphate (CaP) decreases plasma unconjugated bilirubin (UCB) levels.	Bilirubin	43-52	lipase G, endothelial type	Rattus norvegicus	91-97
15726644-1	2005	The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are implicated in xenobiotic and endobiotic detoxification, including the clearance of toxic bilirubin.	Bilirubin	170-179	nuclear receptor subfamily 1, group I, member 3	Mus musculus	38-70
15726644-1	2005	The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are implicated in xenobiotic and endobiotic detoxification, including the clearance of toxic bilirubin.	Bilirubin	170-179	nuclear receptor subfamily 1, group I, member 3	Mus musculus	72-75
15726644-3	2005	Here we reveal a dual role of PXR in bilirubin detoxification in that both the loss and activation of PXR led to protection from hyperbilirubinemia induced by bilirubin infusion or hemolysis.	Bilirubin	37-46	nuclear receptor subfamily 1, group I, member 2	Mus musculus	30-33
15726644-3	2005	Here we reveal a dual role of PXR in bilirubin detoxification in that both the loss and activation of PXR led to protection from hyperbilirubinemia induced by bilirubin infusion or hemolysis.	Bilirubin	37-46	nuclear receptor subfamily 1, group I, member 2	Mus musculus	102-105
15812227-1	2005	Heme oxygenase 1 (HO-1) is an inducible enzyme that catalyzes heme to generate bilirubin, ferritin, and carbon monoxide.	Bilirubin	79-88	heme oxygenase 1	Mus musculus	0-16
15812227-1	2005	Heme oxygenase 1 (HO-1) is an inducible enzyme that catalyzes heme to generate bilirubin, ferritin, and carbon monoxide.	Bilirubin	79-88	heme oxygenase 1	Mus musculus	18-22
15557560-1	2005	UDP-glucuronosyltransferase (UGT) 1A1 glucuronidates endogenous metabolites, such as bilirubin, and exogenous substances, and plays a critical role in their detoxification and excretion.	Bilirubin	85-94	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-37
15737207-2	2005	In skin, UVA photoimmunoprotection is mediated by the inducible antioxidant stress enzyme, heme oxygenase-1 (HO-1), which degrades heme into carbon monoxide (CO), iron, and biliverdin (reduced to bilirubin), and is important for cell survival under conditions of oxidative stress.	Bilirubin	196-205	heme oxygenase 1	Mus musculus	91-107
15726644-3	2005	Here we reveal a dual role of PXR in bilirubin detoxification in that both the loss and activation of PXR led to protection from hyperbilirubinemia induced by bilirubin infusion or hemolysis.	Bilirubin	134-143	nuclear receptor subfamily 1, group I, member 2	Mus musculus	30-33
15726644-3	2005	Here we reveal a dual role of PXR in bilirubin detoxification in that both the loss and activation of PXR led to protection from hyperbilirubinemia induced by bilirubin infusion or hemolysis.	Bilirubin	134-143	nuclear receptor subfamily 1, group I, member 2	Mus musculus	102-105
15726644-4	2005	The increased bilirubin clearance in PXR-null mice was associated with selective upregulation of detoxifying enzymes and transporters, and the pattern of regulation is remarkably similar to that of transgenic mice expressing the activated CAR.	Bilirubin	14-23	nuclear receptor subfamily 1, group I, member 2	Mus musculus	37-40
15726644-4	2005	The increased bilirubin clearance in PXR-null mice was associated with selective upregulation of detoxifying enzymes and transporters, and the pattern of regulation is remarkably similar to that of transgenic mice expressing the activated CAR.	Bilirubin	14-23	nuclear receptor subfamily 1, group I, member 3	Mus musculus	239-242
15726644-5	2005	Interestingly, the increased bilirubin clearance and associated gene regulation were absent in the CAR-null or double-knockout mice.	Bilirubin	29-38	nuclear receptor subfamily 1, group I, member 3	Mus musculus	99-102
15726644-6	2005	In cell cultures, ligand-free PXR specifically suppressed the ability of CAR to induce the multidrug resistance associated protein 2 (MRP2), a bilirubin-detoxifying transporter.	Bilirubin	143-152	nuclear receptor subfamily 1, group I, member 2	Mus musculus	30-33
15726644-6	2005	In cell cultures, ligand-free PXR specifically suppressed the ability of CAR to induce the multidrug resistance associated protein 2 (MRP2), a bilirubin-detoxifying transporter.	Bilirubin	143-152	nuclear receptor subfamily 1, group I, member 3	Mus musculus	73-76
15726644-6	2005	In cell cultures, ligand-free PXR specifically suppressed the ability of CAR to induce the multidrug resistance associated protein 2 (MRP2), a bilirubin-detoxifying transporter.	Bilirubin	143-152	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	91-132
15641110-4	2005	Among the various heat shock proteins, heme oxygenase-1 has received considerable attention; it has been recently demonstrated that heme oxygenase-1 induction, by generating the vasoactive molecule carbon monoxide and the potent antioxidant bilirubin, could represent a protective system potentially active against brain oxidative injury.	Bilirubin	241-250	heme oxygenase 1	Rattus norvegicus	39-55
15641110-4	2005	Among the various heat shock proteins, heme oxygenase-1 has received considerable attention; it has been recently demonstrated that heme oxygenase-1 induction, by generating the vasoactive molecule carbon monoxide and the potent antioxidant bilirubin, could represent a protective system potentially active against brain oxidative injury.	Bilirubin	241-250	heme oxygenase 1	Rattus norvegicus	132-148
15684251-3	2005	Serum alanine aminotransferase and aspartate aminotransferase peaked at postoperative day six (2188 and 425 U*L(-1) respectively), with the development of coagulopathy with an international normalized ratio of 2.29 on postoperative day eight, progressive jaundice with a peak serum total bilirubin of 214 mumol*L(-1) on postoperative day 12 and hepatic encephalopathy on postoperative day ten.	Bilirubin	288-297	glutamic--pyruvic transaminase	Homo sapiens	6-30
15710570-2	2005	We investigated whether susceptibility to cholelithiasis in SCA was associated with the promoter polymorphism of the 5?-diphosphate-glucuronosyltransferase 1A1 (UGT1A1) gene encoding a key enzyme in bilirubin catabolism.	Bilirubin	199-208	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	161-167
15840227-1	2005	OBJECTIVE: To explore the effects of bilirubin on expression of laminin (Ln) and epidermal growth factor (EGF) in lung tissue and in type II pneumocytes (ATII) in smoking rats.	Bilirubin	37-46	epidermal growth factor like 1	Rattus norvegicus	106-109
15770402-6	2005	In the FH patients, the serum cytochrome c level was significantly correlated to serum mitochondria (m)-GOT, hepatocyte growth factor (HGF), aspartate aminotransferase (AST), lactic dehydrogenase (LDH), and alkaline phosphatase (ALP), and it was negatively correlated to serum alpha-fetoprotein (AFP), and total bilirubin (T.Bil.)	Bilirubin	312-321	cytochrome c, somatic	Homo sapiens	30-42
15933765-1	2005	Heme oxygenase-1 (HO-1) is an enzyme which catalyzes the rate-limiting step in heme degradation resulting in the formation of iron, carbon monoxide and biliverdin, which is subsequently converted to bilirubin by biliverdin reductase.	Bilirubin	199-208	heme oxygenase 1	Homo sapiens	18-22
15840227-0	2005	[The effects of bilirubin concentration on laminin and epidermal growth factor expression in lung tissue and type II pneumocytes in smoking rats model].	Bilirubin	16-25	epidermal growth factor like 1	Rattus norvegicus	55-78
15840227-1	2005	OBJECTIVE: To explore the effects of bilirubin on expression of laminin (Ln) and epidermal growth factor (EGF) in lung tissue and in type II pneumocytes (ATII) in smoking rats.	Bilirubin	37-46	epidermal growth factor like 1	Rattus norvegicus	81-104
15840227-12	2005	The expression of EGF in the bilirubin group (0.34 +/- 0.03) decreased significantly compared with the model group (P &lt; 0.05), which was higher than that of the normal group.	Bilirubin	29-38	epidermal growth factor like 1	Rattus norvegicus	18-21
15840227-13	2005	CONCLUSIONS: Bilirubin was shown to be able to promote the reconstruction of extracellular matrix by decreasing the expression of Ln and EGF in lung tissue and in ATII in the development of emphysema.	Bilirubin	13-22	epidermal growth factor like 1	Rattus norvegicus	137-140
15581595-3	2005	As examples, these xenosensors are involved in the homeostasis of cholesterol, bile acids, bilirubin, and other endogenous hydrophobic molecules in the liver: CAR and PXR thus form an intricate regulatory network with other members of the nuclear receptor superfamily, foremost the cholesterol-sensing liver X receptor (LXR, NR1H2/3) and the bile-acid-activated farnesoid X receptor (FXR, NR1H4).	Bilirubin	91-100	nuclear receptor subfamily 1 group I member 3	Homo sapiens	159-162
15581595-3	2005	As examples, these xenosensors are involved in the homeostasis of cholesterol, bile acids, bilirubin, and other endogenous hydrophobic molecules in the liver: CAR and PXR thus form an intricate regulatory network with other members of the nuclear receptor superfamily, foremost the cholesterol-sensing liver X receptor (LXR, NR1H2/3) and the bile-acid-activated farnesoid X receptor (FXR, NR1H4).	Bilirubin	91-100	nuclear receptor subfamily 1 group I member 2	Homo sapiens	167-170
15581595-3	2005	As examples, these xenosensors are involved in the homeostasis of cholesterol, bile acids, bilirubin, and other endogenous hydrophobic molecules in the liver: CAR and PXR thus form an intricate regulatory network with other members of the nuclear receptor superfamily, foremost the cholesterol-sensing liver X receptor (LXR, NR1H2/3) and the bile-acid-activated farnesoid X receptor (FXR, NR1H4).	Bilirubin	91-100	nuclear receptor subfamily 1 group H member 2	Homo sapiens	325-332
15581595-3	2005	As examples, these xenosensors are involved in the homeostasis of cholesterol, bile acids, bilirubin, and other endogenous hydrophobic molecules in the liver: CAR and PXR thus form an intricate regulatory network with other members of the nuclear receptor superfamily, foremost the cholesterol-sensing liver X receptor (LXR, NR1H2/3) and the bile-acid-activated farnesoid X receptor (FXR, NR1H4).	Bilirubin	91-100	nuclear receptor subfamily 1 group H member 4	Homo sapiens	384-387
15581595-3	2005	As examples, these xenosensors are involved in the homeostasis of cholesterol, bile acids, bilirubin, and other endogenous hydrophobic molecules in the liver: CAR and PXR thus form an intricate regulatory network with other members of the nuclear receptor superfamily, foremost the cholesterol-sensing liver X receptor (LXR, NR1H2/3) and the bile-acid-activated farnesoid X receptor (FXR, NR1H4).	Bilirubin	91-100	nuclear receptor subfamily 1 group H member 4	Homo sapiens	389-394
15933765-1	2005	Heme oxygenase-1 (HO-1) is an enzyme which catalyzes the rate-limiting step in heme degradation resulting in the formation of iron, carbon monoxide and biliverdin, which is subsequently converted to bilirubin by biliverdin reductase.	Bilirubin	199-208	heme oxygenase 1	Homo sapiens	0-16
15499042-0	2005	Bilirubin from heme oxygenase-1 attenuates vascular endothelial activation and dysfunction.	Bilirubin	0-9	heme oxygenase 1	Mus musculus	15-31
15499042-8	2005	CONCLUSIONS: These results suggest that the antiatherogenic properties of HO-1 may be mediated predominantly through the action of bilirubin by inhibition of vascular endothelial activation and dysfunction in response to proinflammatory stresses.	Bilirubin	131-140	heme oxygenase 1	Mus musculus	74-78
15881424-1	2005	Crigler-Najjar syndrome type 1 (CN1) is an inherited disorder characterized by the absence of hepatic uridine diphosphoglucuronate glucuronosyltransferase (UDPGT), the enzyme responsible for the conjugation and excretion of bilirubin.	Bilirubin	224-233	5'-nucleotidase, cytosolic IA	Homo sapiens	32-35
15881424-1	2005	Crigler-Najjar syndrome type 1 (CN1) is an inherited disorder characterized by the absence of hepatic uridine diphosphoglucuronate glucuronosyltransferase (UDPGT), the enzyme responsible for the conjugation and excretion of bilirubin.	Bilirubin	224-233	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	156-161
15881424-2	2005	We performed allogenic hepatocyte transplantation (AHT) in a child with CN1, aiming to improve bilirubin glucuronidation in this condition.	Bilirubin	95-104	5'-nucleotidase, cytosolic IA	Homo sapiens	72-75
15786394-4	2005	The results demonstrated that the method, powerfully removing ammonia, bilirubin and bile acids (taken as method efficacy markers), reduced the blood concentrations of these molecules remarkably; allowing the elimination of the refractory pruritus (due to the lowering of plasma bile acid levels), an almost constant symptom in chronic liver diseases, especially with cholestasis, and improves other parameters (cholinesterase, alkaline phosphatase and prothrombin activity).	Bilirubin	71-80	butyrylcholinesterase	Homo sapiens	412-426
15589375-1	2005	Heme oxygenases (HO-1 and HO-2) catalyze the NADPH-cytochrome P(450) reductase (CPR)-dependent degradation of heme into iron, carbon monoxide, and biliverdin, which is reduced into bilirubin.	Bilirubin	181-190	heme oxygenase 1	Homo sapiens	0-30
15786394-4	2005	The results demonstrated that the method, powerfully removing ammonia, bilirubin and bile acids (taken as method efficacy markers), reduced the blood concentrations of these molecules remarkably; allowing the elimination of the refractory pruritus (due to the lowering of plasma bile acid levels), an almost constant symptom in chronic liver diseases, especially with cholestasis, and improves other parameters (cholinesterase, alkaline phosphatase and prothrombin activity).	Bilirubin	71-80	coagulation factor II, thrombin	Homo sapiens	453-464
15589375-1	2005	Heme oxygenases (HO-1 and HO-2) catalyze the NADPH-cytochrome P(450) reductase (CPR)-dependent degradation of heme into iron, carbon monoxide, and biliverdin, which is reduced into bilirubin.	Bilirubin	181-190	cytochrome p450 oxidoreductase	Homo sapiens	45-78
16399345-1	2005	Human UDP-glucuronosyltransferase (UGT) 1A1 is the enzyme that detoxifies neurotoxic bilirubin by conjugating it with glucuronic acid.	Bilirubin	85-94	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	6-43
15589375-1	2005	Heme oxygenases (HO-1 and HO-2) catalyze the NADPH-cytochrome P(450) reductase (CPR)-dependent degradation of heme into iron, carbon monoxide, and biliverdin, which is reduced into bilirubin.	Bilirubin	181-190	cytochrome p450 oxidoreductase	Homo sapiens	80-83
15965581-1	2005	In bilirubin metabolism, increased destruction of erythrocytes, defect in the function of organic anion transporter polypeptide 2 (OATP2) or UDP-glucuronosyltransferase 1A1 (UGT1A1) may result in unconjugated hyperbilirubinemia.	Bilirubin	3-12	solute carrier organic anion transporter family member 1B1	Homo sapiens	90-129
15965581-1	2005	In bilirubin metabolism, increased destruction of erythrocytes, defect in the function of organic anion transporter polypeptide 2 (OATP2) or UDP-glucuronosyltransferase 1A1 (UGT1A1) may result in unconjugated hyperbilirubinemia.	Bilirubin	3-12	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	141-172
15965581-5	2005	The status of the haplotypes of G6PD, OATP2, and UGT1A1 genes affected the odds ratio and the bilirubin levels in the hyperbilirubinemic subjects.	Bilirubin	94-103	glucose-6-phosphate dehydrogenase	Homo sapiens	32-36
15965581-5	2005	The status of the haplotypes of G6PD, OATP2, and UGT1A1 genes affected the odds ratio and the bilirubin levels in the hyperbilirubinemic subjects.	Bilirubin	94-103	solute carrier organic anion transporter family member 1B1	Homo sapiens	38-43
15965581-5	2005	The status of the haplotypes of G6PD, OATP2, and UGT1A1 genes affected the odds ratio and the bilirubin levels in the hyperbilirubinemic subjects.	Bilirubin	94-103	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	49-55
16173058-0	2005	Early steps in bilirubin-mediated apoptosis in murine hepatoma (Hepa 1c1c7) cells are characterized by aryl hydrocarbon receptor-independent oxidative stress and activation of the mitochondrial pathway.	Bilirubin	15-24	aryl-hydrocarbon receptor	Mus musculus	103-128
16399340-6	2005	In humans, lethal hyperbilirubinemic Crigler-Najjar type 1 and milder diseases/syndromes are due to deleterious to mildly deleterious mutations in the bilirubin-specific UGT1A1 or a common exon.	Bilirubin	23-32	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	170-176
15610733-1	2004	Constitutive androstane receptor (CAR) induces xenobiotic, bilirubin, and thyroid hormone metabolism as a heterodimer with the retinoid X receptor (RXR).	Bilirubin	59-68	nuclear receptor subfamily 1 group I member 3	Homo sapiens	0-32
16399344-5	2005	UDP-glucuronosyltransferase 1A1 (UGT1A1), responsible for the glucuronidation of bilirubin, is controlled in a tissue-specific manner and can be regulated following environmental exposure.	Bilirubin	81-90	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-31
16399344-5	2005	UDP-glucuronosyltransferase 1A1 (UGT1A1), responsible for the glucuronidation of bilirubin, is controlled in a tissue-specific manner and can be regulated following environmental exposure.	Bilirubin	81-90	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	33-39
16399368-3	2005	Localization of the efflux pumps ABCC3 and ABCC4 to the basolateral membrane of human hepatocytes has provided insight into the molecular mechanisms of conjugate efflux from hepatocytes into blood, as exemplified by the efflux of bilirubin glucuronosides mediated by ABCC3.	Bilirubin	230-239	ATP binding cassette subfamily C member 3	Homo sapiens	33-38
16399368-3	2005	Localization of the efflux pumps ABCC3 and ABCC4 to the basolateral membrane of human hepatocytes has provided insight into the molecular mechanisms of conjugate efflux from hepatocytes into blood, as exemplified by the efflux of bilirubin glucuronosides mediated by ABCC3.	Bilirubin	230-239	ATP binding cassette subfamily C member 4	Homo sapiens	43-48
16399368-3	2005	Localization of the efflux pumps ABCC3 and ABCC4 to the basolateral membrane of human hepatocytes has provided insight into the molecular mechanisms of conjugate efflux from hepatocytes into blood, as exemplified by the efflux of bilirubin glucuronosides mediated by ABCC3.	Bilirubin	230-239	ATP binding cassette subfamily C member 3	Homo sapiens	267-272
15610733-1	2004	Constitutive androstane receptor (CAR) induces xenobiotic, bilirubin, and thyroid hormone metabolism as a heterodimer with the retinoid X receptor (RXR).	Bilirubin	59-68	nuclear receptor subfamily 1 group I member 3	Homo sapiens	34-37
15610734-1	2004	The nuclear receptor CAR is a xenobiotic responsive transcription factor that plays a central role in the clearance of drugs and bilirubin while promoting cocaine and acetaminophen toxicity.	Bilirubin	129-138	nuclear receptor subfamily 1, group I, member 3	Mus musculus	21-24
15608818-0	2004	CSF bilirubin measurement for xanthochromia.	Bilirubin	4-13	colony stimulating factor 2	Homo sapiens	0-3
15541371-6	2004	The HO-1 metabolite bilirubin, when added exogenously to the cells, virtually abolished NADPH-dependent oxidative stress.	Bilirubin	20-29	heme oxygenase 1	Homo sapiens	4-8
15623611-6	2004	CYP3A activity was reduced by approximately 50% in patients with concurrent elevations in liver transaminases and alkaline phosphatase or elevated total bilirubin (P &lt; 0.001).	Bilirubin	153-162	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-5
15684703-2	2004	After delivery of pDNA encoding hUGT1A1 via hepatic vein or femoral artery, in vitro bilirubin glucuronidation activity was detectable in Gunn rat liver and muscle extracts.	Bilirubin	85-94	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	32-39
15684703-3	2004	Expression of hUGT1A1 in Gunn rat liver or muscle resulted in excretion of bilirubin glucuronides in bile.	Bilirubin	75-84	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	14-21
15684703-8	2004	A 30% decrease in serum bilirubin, if sustained, would provide meaningful clinical benefit for CN-I patients.	Bilirubin	24-33	5'-nucleotidase, cytosolic IA	Homo sapiens	95-99
15531134-3	2004	The inducible enzyme, heme oxygenase-1 metabolizes and thus detoxifies free heme to the powerful endogenous antioxidants biliverdin and bilirubin therefore enhancing neuroprotection.	Bilirubin	136-145	heme oxygenase 1	Homo sapiens	22-38
15584945-7	2004	CONCLUSIONS: A fluorescent compound related to bilirubin increased the BLK-I value in the measurement of neonatal plasma using FPIA.	Bilirubin	47-56	BLK proto-oncogene, Src family tyrosine kinase	Homo sapiens	71-74
15245331-0	2004	The human multidrug-resistance-associated protein MRP1 mediates ATP-dependent transport of unconjugated bilirubin.	Bilirubin	104-113	ATP binding cassette subfamily C member 1	Canis lupus familiaris	50-54
15588241-8	2004	We also found a statistically significant inverse association of adiponectin with jaundice/bilirubin, and a marginally significant positive association of this hormone with IGFBP-3 but no significant association with any maternal factors.	Bilirubin	91-100	adiponectin, C1Q and collagen domain containing	Homo sapiens	65-76
15382069-5	2004	The mechanism(s) by which bilirubin induces apoptosis was investigated by Western blotting for cytochrome c release, assaying for caspase-8 and caspase-9 activation and for mitochondrial depolarization by JC-1 staining.	Bilirubin	26-35	caspase 8	Rattus norvegicus	130-139
15382069-5	2004	The mechanism(s) by which bilirubin induces apoptosis was investigated by Western blotting for cytochrome c release, assaying for caspase-8 and caspase-9 activation and for mitochondrial depolarization by JC-1 staining.	Bilirubin	26-35	caspase 9	Rattus norvegicus	144-153
15382069-8	2004	Cells exhibited substantial apoptosis when exposed to bilirubin concentrations ranging 0-50 microM, as demonstrated by an 8- to 10-fold increase in TUNEL and annexin V staining and in caspase-3 activity.	Bilirubin	54-63	annexin A5	Rattus norvegicus	158-167
15382069-8	2004	Cells exhibited substantial apoptosis when exposed to bilirubin concentrations ranging 0-50 microM, as demonstrated by an 8- to 10-fold increase in TUNEL and annexin V staining and in caspase-3 activity.	Bilirubin	54-63	caspase 3	Rattus norvegicus	184-193
15382069-9	2004	Bilirubin treatment evokes specific activation of caspase-9, enhances cytochrome c release into the cytoplasm and triggers the mitochondrial permeability transition in colon cancer monolayers.	Bilirubin	0-9	caspase 9	Rattus norvegicus	50-59
15558653-7	2004	In vivo serum bilirubin reduction during MARS sessions (n = 26) correlated with pre-treatment bilirubin (r = 0.42), but better (r = 0.85) with pre-treatment molar ratio of bilirubin to albumin (C(bilirubin)/C(alb)).	Bilirubin	14-23	calbindin 1	Homo sapiens	207-213
15558653-8	2004	The strongest correlation was between C(bilirubin)/C(alb) reduction and pre-treatment C(bilirubin)/C(alb) (r = 0.9).	Bilirubin	40-49	calbindin 1	Homo sapiens	99-105
15558653-8	2004	The strongest correlation was between C(bilirubin)/C(alb) reduction and pre-treatment C(bilirubin)/C(alb) (r = 0.9).	Bilirubin	88-97	calbindin 1	Homo sapiens	51-57
15535988-2	2004	OATP-C, OATP2, LST-1, or SLC21A6) is a liver-specific organic anion uptake transporter and has been shown to be a higher affinity bilirubin uptake transporter than OATP1B3.	Bilirubin	130-139	solute carrier organic anion transporter family member 1B1	Homo sapiens	0-6
15535988-2	2004	OATP-C, OATP2, LST-1, or SLC21A6) is a liver-specific organic anion uptake transporter and has been shown to be a higher affinity bilirubin uptake transporter than OATP1B3.	Bilirubin	130-139	solute carrier organic anion transporter family member 1B1	Homo sapiens	8-13
15535988-2	2004	OATP-C, OATP2, LST-1, or SLC21A6) is a liver-specific organic anion uptake transporter and has been shown to be a higher affinity bilirubin uptake transporter than OATP1B3.	Bilirubin	130-139	leukocyte specific transcript 1	Homo sapiens	15-20
15535988-2	2004	OATP-C, OATP2, LST-1, or SLC21A6) is a liver-specific organic anion uptake transporter and has been shown to be a higher affinity bilirubin uptake transporter than OATP1B3.	Bilirubin	130-139	solute carrier organic anion transporter family member 1B1	Homo sapiens	25-32
15535988-2	2004	OATP-C, OATP2, LST-1, or SLC21A6) is a liver-specific organic anion uptake transporter and has been shown to be a higher affinity bilirubin uptake transporter than OATP1B3.	Bilirubin	130-139	solute carrier organic anion transporter family member 1B3	Homo sapiens	164-171
15513578-1	2004	AIM: 1) To compare the clinical assessment of craniocaudal progression of jaundice and two transcutaneous bilirubinometers with serum bilirubin values in preterm neonates; 2) to identify factors affecting the difference between non-invasive bilirubin estimation and serum bilirubin.	Bilirubin	134-143	crystallin beta-gamma domain containing 1	Homo sapiens	0-6
15513578-1	2004	AIM: 1) To compare the clinical assessment of craniocaudal progression of jaundice and two transcutaneous bilirubinometers with serum bilirubin values in preterm neonates; 2) to identify factors affecting the difference between non-invasive bilirubin estimation and serum bilirubin.	Bilirubin	134-143	crystallin beta-gamma domain containing 1	Homo sapiens	0-6
15530192-12	2004	Bilirubin, but not carboxyhemoglobin, correlated with heme oxygenase-1 expression (p = .0013).	Bilirubin	0-9	heme oxygenase 1	Homo sapiens	54-70
15530192-14	2004	Heme oxygenase-1 expression correlated with serum bilirubin levels.	Bilirubin	50-59	heme oxygenase 1	Homo sapiens	0-16
15530192-15	2004	The increase in heme oxygenase-1 expression may add to the understanding of the increase in serum bilirubin observed in patients with SIRS/sepsis.	Bilirubin	98-107	heme oxygenase 1	Homo sapiens	16-32
15245331-1	2004	Results of previous studies have suggested that UCB (unconjugated bilirubin) may be transported by MRP1/Mrp1 (multidrug-resistance-associated protein 1).	Bilirubin	66-75	ATP binding cassette subfamily C member 1	Canis lupus familiaris	99-103
15245331-1	2004	Results of previous studies have suggested that UCB (unconjugated bilirubin) may be transported by MRP1/Mrp1 (multidrug-resistance-associated protein 1).	Bilirubin	66-75	ATP binding cassette subfamily C member 1	Canis lupus familiaris	104-108
15245331-1	2004	Results of previous studies have suggested that UCB (unconjugated bilirubin) may be transported by MRP1/Mrp1 (multidrug-resistance-associated protein 1).	Bilirubin	66-75	ATP binding cassette subfamily C member 1	Canis lupus familiaris	110-151
15245331-8	2004	Collectively, these results prove directly that MRP1 mediates ATP-dependent cellular export of UCB and supports its role in protecting cells from bilirubin toxicity.	Bilirubin	146-155	ATP binding cassette subfamily C member 1	Canis lupus familiaris	48-52
15519273-0	2004	Influence of common variants in the pharmacokinetic genes (OATP-C, UGT1A1, and MRP2) on serum bilirubin levels in healthy subjects.	Bilirubin	94-103	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	67-73
15382119-2	2004	At the hepatic level, the orphan nuclear constitutive androstane receptor (CAR) (NR1I3) controls phase I (cytochrome P450 [CYP] 2B and CYP3A), phase II (UGT1A1), and transporter (SLC21A6, MRP2) genes involved in drug metabolism and bilirubin clearance in response to xenobiotics such as phenobarbital or endobiotics such as bilirubin.	Bilirubin	324-333	nuclear receptor subfamily 1 group I member 3	Homo sapiens	41-73
15382119-2	2004	At the hepatic level, the orphan nuclear constitutive androstane receptor (CAR) (NR1I3) controls phase I (cytochrome P450 [CYP] 2B and CYP3A), phase II (UGT1A1), and transporter (SLC21A6, MRP2) genes involved in drug metabolism and bilirubin clearance in response to xenobiotics such as phenobarbital or endobiotics such as bilirubin.	Bilirubin	324-333	nuclear receptor subfamily 1 group I member 3	Homo sapiens	75-78
15382119-2	2004	At the hepatic level, the orphan nuclear constitutive androstane receptor (CAR) (NR1I3) controls phase I (cytochrome P450 [CYP] 2B and CYP3A), phase II (UGT1A1), and transporter (SLC21A6, MRP2) genes involved in drug metabolism and bilirubin clearance in response to xenobiotics such as phenobarbital or endobiotics such as bilirubin.	Bilirubin	324-333	nuclear receptor subfamily 1 group I member 3	Homo sapiens	81-86
15382119-2	2004	At the hepatic level, the orphan nuclear constitutive androstane receptor (CAR) (NR1I3) controls phase I (cytochrome P450 [CYP] 2B and CYP3A), phase II (UGT1A1), and transporter (SLC21A6, MRP2) genes involved in drug metabolism and bilirubin clearance in response to xenobiotics such as phenobarbital or endobiotics such as bilirubin.	Bilirubin	324-333	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	106-130
15382119-4	2004	We show that IL-1beta decreases CAR expression and decreases phenobarbital- or bilirubin-mediated induction of CYP2B6, CYP2C9, CYP3A4, UGT1A1, GSTA1, GSTA2, and SLC21A6 messenger RNA.	Bilirubin	79-88	interleukin 1 beta	Homo sapiens	13-21
15382119-4	2004	We show that IL-1beta decreases CAR expression and decreases phenobarbital- or bilirubin-mediated induction of CYP2B6, CYP2C9, CYP3A4, UGT1A1, GSTA1, GSTA2, and SLC21A6 messenger RNA.	Bilirubin	79-88	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	111-117
15382119-0	2004	Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance.	Bilirubin	88-97	interleukin 1 beta	Homo sapiens	0-17
15382119-0	2004	Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance.	Bilirubin	88-97	nuclear receptor subfamily 1 group I member 3	Homo sapiens	27-30
15382119-2	2004	At the hepatic level, the orphan nuclear constitutive androstane receptor (CAR) (NR1I3) controls phase I (cytochrome P450 [CYP] 2B and CYP3A), phase II (UGT1A1), and transporter (SLC21A6, MRP2) genes involved in drug metabolism and bilirubin clearance in response to xenobiotics such as phenobarbital or endobiotics such as bilirubin.	Bilirubin	232-241	nuclear receptor subfamily 1 group I member 3	Homo sapiens	41-73
15382119-2	2004	At the hepatic level, the orphan nuclear constitutive androstane receptor (CAR) (NR1I3) controls phase I (cytochrome P450 [CYP] 2B and CYP3A), phase II (UGT1A1), and transporter (SLC21A6, MRP2) genes involved in drug metabolism and bilirubin clearance in response to xenobiotics such as phenobarbital or endobiotics such as bilirubin.	Bilirubin	232-241	nuclear receptor subfamily 1 group I member 3	Homo sapiens	75-78
15382119-4	2004	We show that IL-1beta decreases CAR expression and decreases phenobarbital- or bilirubin-mediated induction of CYP2B6, CYP2C9, CYP3A4, UGT1A1, GSTA1, GSTA2, and SLC21A6 messenger RNA.	Bilirubin	79-88	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	119-125
15519273-0	2004	Influence of common variants in the pharmacokinetic genes (OATP-C, UGT1A1, and MRP2) on serum bilirubin levels in healthy subjects.	Bilirubin	94-103	ATP binding cassette subfamily C member 2	Homo sapiens	79-83
15382119-4	2004	We show that IL-1beta decreases CAR expression and decreases phenobarbital- or bilirubin-mediated induction of CYP2B6, CYP2C9, CYP3A4, UGT1A1, GSTA1, GSTA2, and SLC21A6 messenger RNA.	Bilirubin	79-88	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	127-133
15382119-4	2004	We show that IL-1beta decreases CAR expression and decreases phenobarbital- or bilirubin-mediated induction of CYP2B6, CYP2C9, CYP3A4, UGT1A1, GSTA1, GSTA2, and SLC21A6 messenger RNA.	Bilirubin	79-88	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	135-141
15464257-1	2004	A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR.	Bilirubin	39-48	nuclear receptor subfamily 1, group I, member 3	Mus musculus	94-97
15382119-4	2004	We show that IL-1beta decreases CAR expression and decreases phenobarbital- or bilirubin-mediated induction of CYP2B6, CYP2C9, CYP3A4, UGT1A1, GSTA1, GSTA2, and SLC21A6 messenger RNA.	Bilirubin	79-88	glutathione S-transferase alpha 1	Homo sapiens	143-148
15382119-4	2004	We show that IL-1beta decreases CAR expression and decreases phenobarbital- or bilirubin-mediated induction of CYP2B6, CYP2C9, CYP3A4, UGT1A1, GSTA1, GSTA2, and SLC21A6 messenger RNA.	Bilirubin	79-88	glutathione S-transferase alpha 2	Homo sapiens	150-155
15382119-4	2004	We show that IL-1beta decreases CAR expression and decreases phenobarbital- or bilirubin-mediated induction of CYP2B6, CYP2C9, CYP3A4, UGT1A1, GSTA1, GSTA2, and SLC21A6 messenger RNA.	Bilirubin	79-88	solute carrier organic anion transporter family member 1B1	Homo sapiens	161-168
15382119-2	2004	At the hepatic level, the orphan nuclear constitutive androstane receptor (CAR) (NR1I3) controls phase I (cytochrome P450 [CYP] 2B and CYP3A), phase II (UGT1A1), and transporter (SLC21A6, MRP2) genes involved in drug metabolism and bilirubin clearance in response to xenobiotics such as phenobarbital or endobiotics such as bilirubin.	Bilirubin	232-241	nuclear receptor subfamily 1 group I member 3	Homo sapiens	81-86
15382119-2	2004	At the hepatic level, the orphan nuclear constitutive androstane receptor (CAR) (NR1I3) controls phase I (cytochrome P450 [CYP] 2B and CYP3A), phase II (UGT1A1), and transporter (SLC21A6, MRP2) genes involved in drug metabolism and bilirubin clearance in response to xenobiotics such as phenobarbital or endobiotics such as bilirubin.	Bilirubin	232-241	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	106-130
15464257-3	2004	We recently identified the constitutive androstane receptor (CAR, NR1I3) as a key regulator of bilirubin clearance in the liver.	Bilirubin	95-104	nuclear receptor subfamily 1, group I, member 3	Mus musculus	27-59
15464257-3	2004	We recently identified the constitutive androstane receptor (CAR, NR1I3) as a key regulator of bilirubin clearance in the liver.	Bilirubin	95-104	nuclear receptor subfamily 1, group I, member 3	Mus musculus	61-64
15464257-3	2004	We recently identified the constitutive androstane receptor (CAR, NR1I3) as a key regulator of bilirubin clearance in the liver.	Bilirubin	95-104	nuclear receptor subfamily 1, group I, member 3	Mus musculus	66-71
15464257-4	2004	Here we show that treatment of WT and humanized CAR transgenic mice with Yin Zhi Huang for 3 days accelerates the clearance of intravenously infused bilirubin.	Bilirubin	149-158	nuclear receptor subfamily 1, group I, member 3	Mus musculus	48-51
15464257-6	2004	Expression of bilirubin glucuronyl transferase and other components of the bilirubin metabolism pathway is induced by Yin Zhi Huang treatment of WT mice or mice expressing only human CAR, but not CAR knockout animals.	Bilirubin	14-23	nuclear receptor subfamily 1 group I member 3	Homo sapiens	183-186
15464257-6	2004	Expression of bilirubin glucuronyl transferase and other components of the bilirubin metabolism pathway is induced by Yin Zhi Huang treatment of WT mice or mice expressing only human CAR, but not CAR knockout animals.	Bilirubin	75-84	nuclear receptor subfamily 1 group I member 3	Homo sapiens	183-186
15464257-8	2004	We conclude that CAR mediates the effects of Yin Zhi Huang on bilirubin clearance and that 6,7-dimethylesculetin is an active component of this herbal medicine.	Bilirubin	62-71	nuclear receptor subfamily 1, group I, member 3	Mus musculus	17-20
15636365-1	2004	Human Heme Oxygenase-1 (hHO-1) is the rate-limiting enzyme in the catabolism reaction of heme, which directly regulates the concentration of bilirubin in human body.	Bilirubin	141-150	heme oxygenase 1	Homo sapiens	6-22
15636365-1	2004	Human Heme Oxygenase-1 (hHO-1) is the rate-limiting enzyme in the catabolism reaction of heme, which directly regulates the concentration of bilirubin in human body.	Bilirubin	141-150	heme oxygenase 1	Homo sapiens	24-29
15602829-4	2004	HO-1 activity was indicated by bilirubin and Fe2+ formation.	Bilirubin	31-40	heme oxygenase 1	Homo sapiens	0-4
15338475-2	2004	This study aimed to show the relationship between serum bilirubin levels and plasma nitric oxide and the activity of enzymes in the erythrocyte such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in premature infants.	Bilirubin	56-65	catalase	Homo sapiens	217-225
15338475-2	2004	This study aimed to show the relationship between serum bilirubin levels and plasma nitric oxide and the activity of enzymes in the erythrocyte such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in premature infants.	Bilirubin	56-65	catalase	Homo sapiens	227-230
15334623-6	2004	Inhibition studies with known inhibitors of UGT (diclofenac, flunitrazepam and bilirubin) confirmed the involvement of UGT1A1, UGT1A3 and UGT2B15 in the formation of 3-hydroxydesloratadine-glucuronide.	Bilirubin	79-88	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	44-47
15334623-6	2004	Inhibition studies with known inhibitors of UGT (diclofenac, flunitrazepam and bilirubin) confirmed the involvement of UGT1A1, UGT1A3 and UGT2B15 in the formation of 3-hydroxydesloratadine-glucuronide.	Bilirubin	79-88	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	119-125
15334623-6	2004	Inhibition studies with known inhibitors of UGT (diclofenac, flunitrazepam and bilirubin) confirmed the involvement of UGT1A1, UGT1A3 and UGT2B15 in the formation of 3-hydroxydesloratadine-glucuronide.	Bilirubin	79-88	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	127-133
15334623-6	2004	Inhibition studies with known inhibitors of UGT (diclofenac, flunitrazepam and bilirubin) confirmed the involvement of UGT1A1, UGT1A3 and UGT2B15 in the formation of 3-hydroxydesloratadine-glucuronide.	Bilirubin	79-88	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	138-145
15602829-7	2004	We further observed a time-dependent increase of HO-1 mRNA expression using 100 mmol/L ethanol starting 30 minutes after ethanol exposure, reaching its maximum between 3 h and 9 h. Being similar increased protein expression started to what had been demonstrated with the mRNA level, at 6 h after ethanol exposure, and kept continuous elevated over 18 h. In addition, we found that ethanol exposure to hepatocytes markedly increased HO-1 enzyme activity in a time-dependent manner measured as bilirubin and Fe2+ formation in human hepatocytes.	Bilirubin	492-501	heme oxygenase 1	Homo sapiens	49-53
15472476-7	2004	The apoC-III was significantly (p&lt;0.05) correlated with non-esterified fatty acids (r= -0.526), gamma-glutamyl transpeptidase (r= -0.407), total bilirubin (r= -0.464), positively with apolipoprotein B-100 (apoB-100, r=0.601) and cholesterol ester (r=0.449).	Bilirubin	148-157	apolipoprotein C3	Bos taurus	4-12
15362770-5	2004	The postoperative highest level of total bilirubin (T-Bil) correlated with the decreasing rate of ALP, prothrombin time (PT), total cholesterol (T-CHO) or gamma-GTP and total blood loss (p&lt;0.01).	Bilirubin	41-50	alkaline phosphatase, placental	Homo sapiens	98-101
15362770-5	2004	The postoperative highest level of total bilirubin (T-Bil) correlated with the decreasing rate of ALP, prothrombin time (PT), total cholesterol (T-CHO) or gamma-GTP and total blood loss (p&lt;0.01).	Bilirubin	41-50	coagulation factor II, thrombin	Homo sapiens	103-114
15362770-5	2004	The postoperative highest level of total bilirubin (T-Bil) correlated with the decreasing rate of ALP, prothrombin time (PT), total cholesterol (T-CHO) or gamma-GTP and total blood loss (p&lt;0.01).	Bilirubin	41-50	inactive glutathione hydrolase 2	Homo sapiens	155-164
15362770-16	2004	CONCLUSIONS: Monitoring the ALP level was indicated to be useful to estimate the postoperative course of bilirubin.	Bilirubin	105-114	alkaline phosphatase, placental	Homo sapiens	28-31
15700767-8	2004	Serum AST, ALT, total and conjugated bilirubin, ALP, gamma-GT, and total iron levels were significantly higher in CCl4-treated rats than in the controls, while urea, total protein, and albumin levels were significantly lower.	Bilirubin	37-46	C-C motif chemokine ligand 4	Rattus norvegicus	114-118
15700767-10	2004	However, the elevations in AST, ALT, total and conjugated bilirubin, ALP, gamma-GT, and total iron levels induced by CCl4 injections were significantly reduced by melatonin.	Bilirubin	58-67	C-C motif chemokine ligand 4	Rattus norvegicus	117-121
15560369-1	2004	Human UDP-glucuronosyltransferase (UGT) 1A1 is only enzyme in the conjugation of bilirubin for prevention of hyperbilirubinemia and jaundice.	Bilirubin	81-90	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	6-43
15493144-0	2004	Significant associations of the alpha-adducin gene Gly460Trp polymorphism with serum bilirubin concentrations in Chinese essential hypertension patients.	Bilirubin	85-94	adducin 1	Homo sapiens	32-45
15493144-1	2004	We investigated associations of the Gly460Trp polymorphism of the alpha-adducin gene and concentrations of serum total bilirubin, serum direct bilirubin and serum unconjugated bilirubin in patients with essential hypertension from Anhui, China from September 2000 to January 2001.	Bilirubin	119-128	adducin 1	Homo sapiens	66-79
15493144-5	2004	We concluded that the Trp/Trp genotype of alpha-adducin Gly460Trp was associated with lower serum bilirubin concentrations in this group of Chinese women with essential hypertension.	Bilirubin	98-107	adducin 1	Homo sapiens	42-55
15493144-6	2004	Women with the Trp/Trp genotype of alpha-adducin Gly460Trp might have increased risk for cardiovascular diseases due to lower concentrations of serum bilirubin.	Bilirubin	150-159	adducin 1	Homo sapiens	35-48
15368447-0	2004	Bilirubin inhibits iNOS expression and NO production in response to endotoxin in rats.	Bilirubin	0-9	nitric oxide synthase 2	Rattus norvegicus	19-23
15266614-0	2004	Does bilirubin protect against hemochromatosis gene (HFE) related mortality?	Bilirubin	5-14	homeostatic iron regulator	Homo sapiens	31-46
15266614-0	2004	Does bilirubin protect against hemochromatosis gene (HFE) related mortality?	Bilirubin	5-14	homeostatic iron regulator	Homo sapiens	53-56
15266614-2	2004	We hypothesized that increased levels of serum bilirubin may play a protective role against oxidative stress induced by iron overload in carriers of mutations in the hereditary hemochromatosis gene (HFE).	Bilirubin	47-56	homeostatic iron regulator	Homo sapiens	199-202
15266614-5	2004	Serum bilirubin levels were significantly correlated with serum iron (Pearson"s correlation coefficient (r) = 0.4, P &lt; 0.001), transferrin saturation (r = 0.4, P &lt; 0.001), and serum ferritin (r = 0.2, P &lt; 0.05).	Bilirubin	6-15	transferrin	Homo sapiens	130-141
15266614-6	2004	Carriers of the HFE mutations had higher levels of bilirubin compared to wild-type homozygotes.	Bilirubin	51-60	homeostatic iron regulator	Homo sapiens	16-19
15368447-2	2004	Because HO-1 catalyzes the rate-limiting step in bilirubin synthesis, we examined the hypothesis that bilirubin is a key mediator of HO-1 cytoprotection, employing a rat model of endotoxemia.	Bilirubin	49-58	heme oxygenase 1	Rattus norvegicus	8-12
15368447-2	2004	Because HO-1 catalyzes the rate-limiting step in bilirubin synthesis, we examined the hypothesis that bilirubin is a key mediator of HO-1 cytoprotection, employing a rat model of endotoxemia.	Bilirubin	102-111	heme oxygenase 1	Rattus norvegicus	133-137
15368447-4	2004	Serum levels of NO and tumor necrosis factor alpha, key mediators of endotoxemia, and hepatic inducible nitric oxide synthase (iNOS) expression were significantly lower in bilirubin-treated rodents versus control animals.	Bilirubin	172-181	tumor necrosis factor	Rattus norvegicus	23-50
15368447-4	2004	Serum levels of NO and tumor necrosis factor alpha, key mediators of endotoxemia, and hepatic inducible nitric oxide synthase (iNOS) expression were significantly lower in bilirubin-treated rodents versus control animals.	Bilirubin	172-181	nitric oxide synthase 2	Rattus norvegicus	94-125
15368447-4	2004	Serum levels of NO and tumor necrosis factor alpha, key mediators of endotoxemia, and hepatic inducible nitric oxide synthase (iNOS) expression were significantly lower in bilirubin-treated rodents versus control animals.	Bilirubin	172-181	nitric oxide synthase 2	Rattus norvegicus	127-131
15368447-6	2004	Consistent with in vivo results, bilirubin significantly inhibited iNOS expression and suppressed NO production in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophages.	Bilirubin	33-42	nitric oxide synthase 2, inducible	Mus musculus	67-71
15368447-9	2004	Taken together, these data support a cytoprotective role for bilirubin that is mediated, at least in part, through the inhibition of iNOS expression and, potentially, through stimulation of local prostaglandin E2 production.	Bilirubin	61-70	nitric oxide synthase 2	Rattus norvegicus	133-137
15226216-6	2004	Bilirubin, one of the byproducts of heme degradation by HO-1, mediated the suppressive effect through the inhibition of Ang II-induced production of reactive oxygen species, as detected by a 2",7"-dichlorofluorescein probe.	Bilirubin	0-9	heme oxygenase 1	Rattus norvegicus	56-60
15284531-1	2004	BACKGROUND: UDP-glucuronosyltransferase (UGT) enzymes catalyze the glucuronidation and typically inactivation of endogenous and exogenous molecules including steroid hormones, bilirubin and many drugs.	Bilirubin	176-185	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	12-39
15284531-1	2004	BACKGROUND: UDP-glucuronosyltransferase (UGT) enzymes catalyze the glucuronidation and typically inactivation of endogenous and exogenous molecules including steroid hormones, bilirubin and many drugs.	Bilirubin	176-185	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	41-44
15338853-11	2004	Vasopressin was associated with ischemia of the mesenteric mucosa, skin, and myocardium; elevated hepatic transaminase and bilirubin concentrations; hyponatremia; and thrombocytopenia.	Bilirubin	123-132	arginine vasopressin	Homo sapiens	0-11
15226216-6	2004	Bilirubin, one of the byproducts of heme degradation by HO-1, mediated the suppressive effect through the inhibition of Ang II-induced production of reactive oxygen species, as detected by a 2",7"-dichlorofluorescein probe.	Bilirubin	0-9	angiotensinogen	Rattus norvegicus	120-126
15226216-9	2004	CONCLUSIONS: HO-1 attenuates Ang II-induced cardiac hypertrophy both in vitro and in vivo, and bilirubin mediates, at least in part, the antihypertrophic effect of HO-1 via inhibition of reactive oxygen species production after Ang II stimulation.	Bilirubin	95-104	heme oxygenase 1	Rattus norvegicus	164-168
15226216-9	2004	CONCLUSIONS: HO-1 attenuates Ang II-induced cardiac hypertrophy both in vitro and in vivo, and bilirubin mediates, at least in part, the antihypertrophic effect of HO-1 via inhibition of reactive oxygen species production after Ang II stimulation.	Bilirubin	95-104	angiotensinogen	Rattus norvegicus	228-234
15194559-3	2004	Remarkably, a transient increase in the bile flow ( approximately 2-fold) and a slight increase in the total biliary bilirubin excretion were observed in SD rats but not in the EHBR after PCG administration.	Bilirubin	117-126	psoriasis susceptibility 1 candidate 2	Rattus norvegicus	188-191
15237425-4	2004	RESULTS: Serum VCAM-1 level in HCC patients was inversely correlated with platelet count (r=-0.431, P&lt;0.001) and serum albumin level (r=-0.279, P&lt;0.001), and positively correlated with serum bilirubin level (r=0.379, P&lt;0.001).	Bilirubin	197-206	vascular cell adhesion molecule 1	Homo sapiens	15-21
15123630-1	2004	Heme-oxygenase-1 (HO-1), the rate-limiting enzyme of heme degradation, has powerful anti-oxidant properties related to the production of the reactive oxygen species scavenger bilirubin.	Bilirubin	175-184	heme oxygenase 1	Rattus norvegicus	0-16
15123630-1	2004	Heme-oxygenase-1 (HO-1), the rate-limiting enzyme of heme degradation, has powerful anti-oxidant properties related to the production of the reactive oxygen species scavenger bilirubin.	Bilirubin	175-184	heme oxygenase 1	Rattus norvegicus	18-22
15537167-5	2004	The lowering of cytochrome P-450 levels on noscapine administration was accompanied by a concomitant increase in heme oxygenase activity as well as serum bilirubin levels.	Bilirubin	154-163	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	16-32
23105470-5	2004	There was a significant positive correlation between ADA and total bilirubin and MDA and total bilirubin.	Bilirubin	67-76	adenosine deaminase	Homo sapiens	53-56
23105470-5	2004	There was a significant positive correlation between ADA and total bilirubin and MDA and total bilirubin.	Bilirubin	95-104	adenosine deaminase	Homo sapiens	53-56
15099818-0	2004	Bilirubin UDP-glucuronosyltransferase 1A1 (UGT1A1) gene promoter polymorphisms and HPRT, glycophorin A, and micronuclei mutant frequencies in human blood.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	10-41
15179405-0	2004	UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer.	Bilirubin	78-87	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
15179405-10	2004	CONCLUSION: This study identified several UGT1A1 haplotypes significantly associated with the reduced AUC ratio (*28 and *6) and with the increased total bilirubin level (*28, *60, and *IB) and suggested that the novel haplotype *IB might be functionally important.	Bilirubin	154-163	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	42-48
14988408-1	2004	Biliverdin IXalpha reductase (BVR) catalyzes reduction of the HO activity product, biliverdin, to bilirubin.	Bilirubin	98-107	biliverdin reductase A	Homo sapiens	0-28
14988408-1	2004	Biliverdin IXalpha reductase (BVR) catalyzes reduction of the HO activity product, biliverdin, to bilirubin.	Bilirubin	98-107	biliverdin reductase A	Homo sapiens	30-33
15233805-3	2004	HO-1 catalyzes heme breakdown to release iron, carbon monoxide, and biliverdin, which is reduced to bilirubin, a potent radical scavenger.	Bilirubin	100-109	heme oxygenase 1	Homo sapiens	0-4
15229832-3	2004	Apo D shows affinity to different molecules like cholesterol, progesterone, bilirubin and arachidonic acid, but its physiological ligand is yet unknown.	Bilirubin	76-85	apolipoprotein D	Homo sapiens	0-5
15147421-7	2004	The increased serum levels of ALT and bilirubin observed after transplantation were significantly reduced by Ref-1 overexpression.	Bilirubin	38-47	apurinic/apyrimidinic endodeoxyribonuclease 1	Rattus norvegicus	109-114
15448807-11	2004	The presence of ABO blood group incompatibility was a significant variable in relation to unconjugated bilirubin that required phototherapy.	Bilirubin	103-112	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	16-31
15099818-0	2004	Bilirubin UDP-glucuronosyltransferase 1A1 (UGT1A1) gene promoter polymorphisms and HPRT, glycophorin A, and micronuclei mutant frequencies in human blood.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	43-49
15099818-4	2004	Because bilirubin is a known antioxidant, we hypothesized that UGT1A1 repeats associated with higher bilirubin may be protective against oxidative damage.	Bilirubin	8-17	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	63-69
15099818-4	2004	Because bilirubin is a known antioxidant, we hypothesized that UGT1A1 repeats associated with higher bilirubin may be protective against oxidative damage.	Bilirubin	101-110	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	63-69
15341181-8	2004	In particular, HSP32, also known as heme oxygenase-1 (HO-1), has received considerable attention, as it has been recently demonstrated that HO-1 induction, by generating the vasoactive molecule carbon monoxide and the potent antioxidant bilirubin, could represent a protective system potentially active against brain oxidative injury.	Bilirubin	237-246	heme oxygenase 1	Homo sapiens	15-20
15135348-2	2004	Bilirubin UDP-glucuronosyltransferase (UGT1A1), which plays a critical role in bilirubin glucuronidation, has been reported to be deficient in CNS type 1.	Bilirubin	79-88	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	39-45
15135348-16	2004	Deficient UGT1A1 activity-associated retention of unconjugated bilirubin in the hepatocytes may modulate the expressions of these transporters in Gunn rats.	Bilirubin	63-72	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	10-16
15341181-8	2004	In particular, HSP32, also known as heme oxygenase-1 (HO-1), has received considerable attention, as it has been recently demonstrated that HO-1 induction, by generating the vasoactive molecule carbon monoxide and the potent antioxidant bilirubin, could represent a protective system potentially active against brain oxidative injury.	Bilirubin	237-246	heme oxygenase 1	Homo sapiens	36-52
15341181-8	2004	In particular, HSP32, also known as heme oxygenase-1 (HO-1), has received considerable attention, as it has been recently demonstrated that HO-1 induction, by generating the vasoactive molecule carbon monoxide and the potent antioxidant bilirubin, could represent a protective system potentially active against brain oxidative injury.	Bilirubin	237-246	heme oxygenase 1	Homo sapiens	54-58
15341181-8	2004	In particular, HSP32, also known as heme oxygenase-1 (HO-1), has received considerable attention, as it has been recently demonstrated that HO-1 induction, by generating the vasoactive molecule carbon monoxide and the potent antioxidant bilirubin, could represent a protective system potentially active against brain oxidative injury.	Bilirubin	237-246	heme oxygenase 1	Homo sapiens	140-144
15083066-10	2004	We identified monoglucuronosyl bilirubin, bisglucuronosyl bilirubin and leukotriene C4 as substrates for both MRP3 and MRP3-ArgHis.	Bilirubin	31-40	ATP binding cassette subfamily B member 4	Homo sapiens	110-114
15063328-1	2004	In this study, we employed ethylene vinyl alcohol (EVAL) adsorptive membranes with bovine serum albumin (BSA) as bioligand for affinity supports for bilirubin (BR) retention.	Bilirubin	149-158	albumin	Homo sapiens	90-103
15160305-5	2004	High plasma HGF was significantly correlated with the presence of infection and with serum total bilirubin (TB) level on multivariate logistic regression analysis.	Bilirubin	97-106	hepatocyte growth factor	Homo sapiens	12-15
15160305-5	2004	High plasma HGF was significantly correlated with the presence of infection and with serum total bilirubin (TB) level on multivariate logistic regression analysis.	Bilirubin	108-110	hepatocyte growth factor	Homo sapiens	12-15
15064336-9	2004	Increased post-treatment bilirubin levels were observed across all treatments in five patients, four of whom had CT or AFP evidence of intrahepatic disease progression.	Bilirubin	25-34	alpha fetoprotein	Homo sapiens	119-122
15004156-1	2004	Heme oxygenase-1 (HO-1) cleaves the porphyrin ring of heme into carbon monoxide, Fe2+, and biliverdin, which is then converted into bilirubin.	Bilirubin	132-141	heme oxygenase 1	Homo sapiens	0-16
15004156-1	2004	Heme oxygenase-1 (HO-1) cleaves the porphyrin ring of heme into carbon monoxide, Fe2+, and biliverdin, which is then converted into bilirubin.	Bilirubin	132-141	heme oxygenase 1	Homo sapiens	18-22
15004156-8	2004	Bilirubin and/or Fe2+ chelation mimicked the effects of HO-1, whereas biliverdin or carbon monoxide did not.	Bilirubin	0-9	heme oxygenase 1	Homo sapiens	56-60
15004156-10	2004	This effect of HO-1 is mediated by bilirubin and/or by a decrease of free intracellular Fe2+ but probably not by biliverdin or carbon monoxide.	Bilirubin	35-44	heme oxygenase 1	Homo sapiens	15-19
14766238-8	2004	In conclusion, HO-1 upregulation in diabetic rats brings about an increase in serum bilirubin, a reduction in O*-2 production, and a decrease in endothelial cell sloughing.	Bilirubin	84-93	heme oxygenase 1	Rattus norvegicus	15-19
14972648-7	2004	Bilirubin levels in G6PD-deficient neonates were somewhat higher compared to G6PD-normal babies (18.8 +/- 2.4 mg/dl [321.5 +/- 41 micromol/l] vs. 15.7 +/- 3.2 mg/dl [268.5 +/- 54.7 micromol/l]; P &lt; 0.05).	Bilirubin	0-9	glucose-6-phosphate dehydrogenase	Homo sapiens	20-24
15080557-7	2004	Multiple regression analysis showed that postoperative changes in fibrinogen (deltaFIB, micromol/l) were simultaneously related to the number of resected liver segments (NSEG), total bilirubin (BIL, micromol/l), aspartate aminotransferase (AST, U/l, n.v. 5-45), albumin (ALB, g/l), prothrombin activity (PA, % of standard reference), age (AGE, years) and basal preoperative fibrinogen (PFIB, micromol/l): deltaFIB = -0.51(NSEG) - 0.71(Log(n)BIL) - 0.74(Log(n)AST) + 0.11(ALB) + 0.09(PA) - 0.06(AGE) - 0.55(PFIB) + 7.74 (n=362, r2=0.68, p&lt;0.001).	Bilirubin	183-192	fibrinogen beta chain	Homo sapiens	66-76
15080557-7	2004	Multiple regression analysis showed that postoperative changes in fibrinogen (deltaFIB, micromol/l) were simultaneously related to the number of resected liver segments (NSEG), total bilirubin (BIL, micromol/l), aspartate aminotransferase (AST, U/l, n.v. 5-45), albumin (ALB, g/l), prothrombin activity (PA, % of standard reference), age (AGE, years) and basal preoperative fibrinogen (PFIB, micromol/l): deltaFIB = -0.51(NSEG) - 0.71(Log(n)BIL) - 0.74(Log(n)AST) + 0.11(ALB) + 0.09(PA) - 0.06(AGE) - 0.55(PFIB) + 7.74 (n=362, r2=0.68, p&lt;0.001).	Bilirubin	194-197	fibrinogen beta chain	Homo sapiens	66-76
14977862-9	2004	Since OATP transporters are important in the hepatic handling of bile acids, bilirubin, and other endogenous anionic compounds, M-1 may disturb the hepatic influx and efflux transport of these endogenous molecules across the basolateral membranes.	Bilirubin	77-86	solute carrier organic anion transporter family member 1A2	Homo sapiens	6-10
15283270-9	2004	The level of sIL-2R and TNF-alpha directly correlated with that of TBL (r=0.331 P&lt;0.05, r=0.518 P&lt;0.01) and ALT (r=0.475 P&lt;0.01, r=0.285 P&lt;0.05) respectively, but inversely correlated with the level of ALB (r=-0.319 P&lt;0.05, r=-0.665 P&lt;0.01).	Bilirubin	67-70	tumor necrosis factor	Homo sapiens	24-33
15283270-9	2004	The level of sIL-2R and TNF-alpha directly correlated with that of TBL (r=0.331 P&lt;0.05, r=0.518 P&lt;0.01) and ALT (r=0.475 P&lt;0.01, r=0.285 P&lt;0.05) respectively, but inversely correlated with the level of ALB (r=-0.319 P&lt;0.05, r=-0.665 P&lt;0.01).	Bilirubin	67-70	albumin	Homo sapiens	214-217
14983033-0	2004	Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug resistance-associated protein 1 (Mrp1).	Bilirubin	0-9	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	99-140
14983033-0	2004	Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug resistance-associated protein 1 (Mrp1).	Bilirubin	0-9	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	142-146
14733911-5	2004	A protective effect similar to L-alanine was observed when preincubating the cells with iron-free apoferritin or the antioxidant HO-1 product, bilirubin.	Bilirubin	143-152	heme oxygenase 1	Homo sapiens	129-133
14707007-4	2004	In the presence of 0.1% FBS media, hemin induced p21 through an HO-dependent, p53-independent mechanism; certain products of HO activity (iron and carbon monoxide), but not others (ferritin, apoferritin, bilirubin), recapitulated these inductive effects on p21 expression.	Bilirubin	204-213	KRAS proto-oncogene, GTPase	Rattus norvegicus	49-52
15017473-5	2004	UC AFP levels were linearly correlated with subsequent bilirubin levels, and significantly higher bilirubin levels were found in neonates whose UC AFP levels were 100 mg/L or more.	Bilirubin	55-64	alpha fetoprotein	Homo sapiens	3-6
15017473-5	2004	UC AFP levels were linearly correlated with subsequent bilirubin levels, and significantly higher bilirubin levels were found in neonates whose UC AFP levels were 100 mg/L or more.	Bilirubin	98-107	alpha fetoprotein	Homo sapiens	147-150
14744950-4	2004	The formation of glucuronide by human liver microsomes and UGT1A4 was inhibited by bilirubin, a known inhibitor of UGT1A4.	Bilirubin	83-92	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	59-65
14744950-4	2004	The formation of glucuronide by human liver microsomes and UGT1A4 was inhibited by bilirubin, a known inhibitor of UGT1A4.	Bilirubin	83-92	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	115-121
14759565-2	2004	Hsp32, also known as heme oxygenase 1, catalyzes the degradation of heme to produce carbon monoxide and bilirubin, which play a variety of cytoprotective functions at physiological concentrations, and iron, which is rapidly sequestered by the iron-binding protein ferritin.	Bilirubin	104-113	heme oxygenase 1	Rattus norvegicus	0-5
14759565-2	2004	Hsp32, also known as heme oxygenase 1, catalyzes the degradation of heme to produce carbon monoxide and bilirubin, which play a variety of cytoprotective functions at physiological concentrations, and iron, which is rapidly sequestered by the iron-binding protein ferritin.	Bilirubin	104-113	heme oxygenase 1	Rattus norvegicus	21-37
14968347-7	2004	Additionally, PETriN enhanced the enzymatic activity of HO-1 measured as formation of the HO-1 metabolites bilirubin (Figure 3) and carbon monoxide (Figure 4) in lysates from endothelial cells.	Bilirubin	107-116	heme oxygenase 1	Homo sapiens	56-60
14968347-7	2004	Additionally, PETriN enhanced the enzymatic activity of HO-1 measured as formation of the HO-1 metabolites bilirubin (Figure 3) and carbon monoxide (Figure 4) in lysates from endothelial cells.	Bilirubin	107-116	heme oxygenase 1	Homo sapiens	90-94
15180166-2	2004	The underlying cause of GS is a polymorphism in the promotor region of the uridine diphosphate glucuronosyltransferase isoform 1A1 gene (UGT1A1*28), its encoded enzyme being responsible for the glucuronidation of bilirubin and presumably acetaminophen.	Bilirubin	213-222	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	137-143
15013185-7	2004	markedly prevented CCl4-induced elevation of levels of serum GPT, GOT, ACP, ALP, and bilirubin.	Bilirubin	85-94	C-C motif chemokine ligand 4	Rattus norvegicus	19-23
14724430-2	2004	In physiologic status, bilirubin is excreted from hepatocytes to the bile canaliculus by means of multidrug resistance protein (MRP) 2 and, in particular circumstances, by means of MRP3 to the sinusoidal space.	Bilirubin	23-32	ATP binding cassette subfamily C member 2	Rattus norvegicus	98-134
14724430-2	2004	In physiologic status, bilirubin is excreted from hepatocytes to the bile canaliculus by means of multidrug resistance protein (MRP) 2 and, in particular circumstances, by means of MRP3 to the sinusoidal space.	Bilirubin	23-32	ATP binding cassette subfamily C member 3	Rattus norvegicus	181-185
14724430-3	2004	The aim of this study was to research whether there is any change in bilirubin excretion pattern during liver regeneration with reference to expression of MRP2 and MRP3.	Bilirubin	69-78	ATP binding cassette subfamily C member 2	Rattus norvegicus	155-159
14724430-3	2004	The aim of this study was to research whether there is any change in bilirubin excretion pattern during liver regeneration with reference to expression of MRP2 and MRP3.	Bilirubin	69-78	ATP binding cassette subfamily C member 3	Rattus norvegicus	164-168
14739596-7	2004	HO-1 is believed to exert this antiapoptotic action by multiple mechanisms: (a) decreased intracellular pro-oxidant levels, (b) increased bilirubin levels, and (c) elevated CO production.	Bilirubin	138-147	heme oxygenase 1	Mus musculus	0-4
15777021-6	2004	The existence of a constitutive haem oxygenase (HO-2), mainly present in the vasculature and nervous system, and an inducible haem oxygenase (HO-1), which is highly expressed during stress conditions in all tissues, also suggests that cells have evolved a fine control of this enzymic pathway to ultimately regulate haem consumption and to ensure production of CO, biliverdin/bilirubin and iron during physiological and pathophysiological situations.	Bilirubin	376-385	heme oxygenase 1	Homo sapiens	142-146
14744740-2	2004	The UGT1A1*28 allelic variant contains an additional (TA) dinucleotide repeat in the "TATAA" box [(TA)(6)&gt;(TA)(7)] of the UGT1A1 promoter that has been linked to decreased expression of the UGT1A1 gene and decreased bilirubin conjugation, leading to the relatively nondebilitating condition known as Gilbert"s syndrome.	Bilirubin	219-228	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	4-10
14744740-2	2004	The UGT1A1*28 allelic variant contains an additional (TA) dinucleotide repeat in the "TATAA" box [(TA)(6)&gt;(TA)(7)] of the UGT1A1 promoter that has been linked to decreased expression of the UGT1A1 gene and decreased bilirubin conjugation, leading to the relatively nondebilitating condition known as Gilbert"s syndrome.	Bilirubin	219-228	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	125-131
14744740-2	2004	The UGT1A1*28 allelic variant contains an additional (TA) dinucleotide repeat in the "TATAA" box [(TA)(6)&gt;(TA)(7)] of the UGT1A1 promoter that has been linked to decreased expression of the UGT1A1 gene and decreased bilirubin conjugation, leading to the relatively nondebilitating condition known as Gilbert"s syndrome.	Bilirubin	219-228	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	125-131
14744740-4	2004	Significant decreases in UGT1A1 protein (P &lt; 0.005) and bilirubin conjugation activity (P &lt; 0.001) were observed in liver microsomes from subjects homozygous for the UGT1A1*28 allelic variant compared with subjects homozygous for the wild-type UGT1A1*1 allele.	Bilirubin	59-68	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	172-178
14744740-4	2004	Significant decreases in UGT1A1 protein (P &lt; 0.005) and bilirubin conjugation activity (P &lt; 0.001) were observed in liver microsomes from subjects homozygous for the UGT1A1*28 allelic variant compared with subjects homozygous for the wild-type UGT1A1*1 allele.	Bilirubin	59-68	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	172-178
14702117-0	2004	A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR.	Bilirubin	39-48	nuclear receptor subfamily 1, group I, member 3	Mus musculus	94-97
14702117-2	2004	We recently identified the constitutive androstane receptor (CAR, NR1I3) as a key regulator of bilirubin clearance in the liver.	Bilirubin	95-104	nuclear receptor subfamily 1, group I, member 3	Mus musculus	27-59
14702117-2	2004	We recently identified the constitutive androstane receptor (CAR, NR1I3) as a key regulator of bilirubin clearance in the liver.	Bilirubin	95-104	nuclear receptor subfamily 1, group I, member 3	Mus musculus	61-64
14702117-2	2004	We recently identified the constitutive androstane receptor (CAR, NR1I3) as a key regulator of bilirubin clearance in the liver.	Bilirubin	95-104	nuclear receptor subfamily 1, group I, member 3	Mus musculus	66-71
14702117-3	2004	Here we show that treatment of WT and humanized CAR transgenic mice with Yin Zhi Huang for 3 days accelerates the clearance of intravenously infused bilirubin.	Bilirubin	149-158	nuclear receptor subfamily 1, group I, member 3	Mus musculus	48-51
14702117-5	2004	Expression of bilirubin glucuronyl transferase and other components of the bilirubin metabolism pathway is induced by Yin Zhi Huang treatment of WT mice or mice expressing only human CAR, but not CAR knockout animals.	Bilirubin	14-23	nuclear receptor subfamily 1 group I member 3	Homo sapiens	183-186
14702117-5	2004	Expression of bilirubin glucuronyl transferase and other components of the bilirubin metabolism pathway is induced by Yin Zhi Huang treatment of WT mice or mice expressing only human CAR, but not CAR knockout animals.	Bilirubin	75-84	nuclear receptor subfamily 1 group I member 3	Homo sapiens	183-186
14702117-7	2004	We conclude that CAR mediates the effects of Yin Zhi Huang on bilirubin clearance and that 6,7-dimethylesculetin is an active component of this herbal medicine.	Bilirubin	62-71	nuclear receptor subfamily 1, group I, member 3	Mus musculus	17-20
14691581-0	2004	A microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with increased bilirubin and HDL levels but not with coronary artery disease.	Bilirubin	97-106	heme oxygenase 1	Homo sapiens	37-53
14691581-1	2004	Heme oxygenase 1 (HO-1) is involved in the generation of the endogenous anti-oxidant bilirubin which exerts beneficial effects against arteriosclerosis.	Bilirubin	85-94	heme oxygenase 1	Homo sapiens	0-16
14691581-1	2004	Heme oxygenase 1 (HO-1) is involved in the generation of the endogenous anti-oxidant bilirubin which exerts beneficial effects against arteriosclerosis.	Bilirubin	85-94	heme oxygenase 1	Homo sapiens	18-22
14665418-0	2003	p38 MAP kinase mediates bilirubin-induced neuronal death of cultured rat cerebellar granule neurons.	Bilirubin	24-33	mitogen activated protein kinase 14	Rattus norvegicus	0-3
14665418-4	2003	In this study, bilirubin markedly induces an early activation of p38 MAP kinase at 1 h. Pretreatment of neurons with a p38 MAP kinase inhibitor, SB 203580, significantly protected CGN against bilirubin-induced neurotoxicity.	Bilirubin	15-24	mitogen activated protein kinase 14	Rattus norvegicus	65-68
14665418-4	2003	In this study, bilirubin markedly induces an early activation of p38 MAP kinase at 1 h. Pretreatment of neurons with a p38 MAP kinase inhibitor, SB 203580, significantly protected CGN against bilirubin-induced neurotoxicity.	Bilirubin	15-24	mitogen activated protein kinase 14	Rattus norvegicus	119-122
14665418-4	2003	In this study, bilirubin markedly induces an early activation of p38 MAP kinase at 1 h. Pretreatment of neurons with a p38 MAP kinase inhibitor, SB 203580, significantly protected CGN against bilirubin-induced neurotoxicity.	Bilirubin	192-201	mitogen activated protein kinase 14	Rattus norvegicus	65-68
14665418-4	2003	In this study, bilirubin markedly induces an early activation of p38 MAP kinase at 1 h. Pretreatment of neurons with a p38 MAP kinase inhibitor, SB 203580, significantly protected CGN against bilirubin-induced neurotoxicity.	Bilirubin	192-201	mitogen activated protein kinase 14	Rattus norvegicus	119-122
14665418-5	2003	Our data suggest that hyperphosphorylation of p38 MAP kinase plays an important role in bilirubin-induced neuronal death and provides a novel approach to discovering drugs to treat bilirubin-induced encephalopathy.	Bilirubin	88-97	mitogen activated protein kinase 14	Rattus norvegicus	46-49
14665418-5	2003	Our data suggest that hyperphosphorylation of p38 MAP kinase plays an important role in bilirubin-induced neuronal death and provides a novel approach to discovering drugs to treat bilirubin-induced encephalopathy.	Bilirubin	181-190	mitogen activated protein kinase 14	Rattus norvegicus	46-49
14633881-0	2003	Haplotype structure of the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene and its relationship to serum total bilirubin concentration in a male Korean population.	Bilirubin	109-118	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	27-58
14633881-0	2003	Haplotype structure of the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene and its relationship to serum total bilirubin concentration in a male Korean population.	Bilirubin	109-118	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	60-66
14692715-0	2003	The role of hepatic Mrp2 in the interaction of flavopiridol and bilirubin: impact on therapy.	Bilirubin	64-73	ATP binding cassette subfamily C member 2	Homo sapiens	20-24
14623264-0	2003	Upregulation in the expression of multidrug resistance protein Mrp1 mRNA and protein by increased bilirubin production in rat.	Bilirubin	98-107	ATP binding cassette subfamily C member 1	Rattus norvegicus	63-67
14623264-1	2003	Earlier studies suggest that Mrp1 may mediate ATP-dependent cellular extrusion of unconjugated bilirubin (UCB).	Bilirubin	95-104	ATP binding cassette subfamily C member 1	Rattus norvegicus	29-33
14623264-2	2003	We studied the serial responses of expression of Mrp1 mRNA and protein in rats with increased bilirubin production due to hemolysis induced by phenylhydrazine (PHZ) treatment.	Bilirubin	94-103	ATP binding cassette subfamily C member 1	Rattus norvegicus	49-53
12923173-5	2003	A role for CAR in protection against bile acid toxicity was confirmed by a marked reduction of serum bile acid and bilirubin concentrations, with an elevation of the expression of the hepatic genes involved in bile acid and/or bilirubin metabolism and excretion (CYP2B, CYP3A, MRP2, MRP3, UGT1A, and glutathione S-transferase alpha), following pretreatment with phenobarbital or TCPOBOP.	Bilirubin	115-124	nuclear receptor subfamily 1, group I, member 3	Mus musculus	11-14
12923173-5	2003	A role for CAR in protection against bile acid toxicity was confirmed by a marked reduction of serum bile acid and bilirubin concentrations, with an elevation of the expression of the hepatic genes involved in bile acid and/or bilirubin metabolism and excretion (CYP2B, CYP3A, MRP2, MRP3, UGT1A, and glutathione S-transferase alpha), following pretreatment with phenobarbital or TCPOBOP.	Bilirubin	227-236	nuclear receptor subfamily 1, group I, member 3	Mus musculus	11-14
12955395-7	2003	Using CD, bilirubin was also applied as a ligand specific to site III of HSA.	Bilirubin	10-19	albumin	Homo sapiens	73-76
14981926-0	2003	Conjugated bilirubin induces multidrug resistance-associated protein 2 mRNA expression and in vivo cisplatin resistance in rat hepatoma AH66 cells.	Bilirubin	11-20	ATP binding cassette subfamily C member 2	Rattus norvegicus	29-70
14981926-10	2003	These results indicated that conjugated bilirubin, a component of ASF, induces the mRNA expression of MRP2, which is a determinant of the in vivo cisplatin resistance of AH66 cells.	Bilirubin	40-49	ATP binding cassette subfamily C member 2	Rattus norvegicus	102-106
14705859-2	2003	The orphan nuclear receptor CAR (NR1I3 controls phase I (CYP2B, CYP2C, CYP3A), phase II (UGT1A1), and transporter (SLC21A6, MRP2) genes involved in drug metabolism and bilirubin clearance.	Bilirubin	168-177	nuclear receptor subfamily 1 group I member 3	Homo sapiens	28-31
14705859-2	2003	The orphan nuclear receptor CAR (NR1I3 controls phase I (CYP2B, CYP2C, CYP3A), phase II (UGT1A1), and transporter (SLC21A6, MRP2) genes involved in drug metabolism and bilirubin clearance.	Bilirubin	168-177	nuclear receptor subfamily 1 group I member 3	Homo sapiens	33-38
14705859-2	2003	The orphan nuclear receptor CAR (NR1I3 controls phase I (CYP2B, CYP2C, CYP3A), phase II (UGT1A1), and transporter (SLC21A6, MRP2) genes involved in drug metabolism and bilirubin clearance.	Bilirubin	168-177	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	64-69
14705859-2	2003	The orphan nuclear receptor CAR (NR1I3 controls phase I (CYP2B, CYP2C, CYP3A), phase II (UGT1A1), and transporter (SLC21A6, MRP2) genes involved in drug metabolism and bilirubin clearance.	Bilirubin	168-177	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	71-76
14705859-2	2003	The orphan nuclear receptor CAR (NR1I3 controls phase I (CYP2B, CYP2C, CYP3A), phase II (UGT1A1), and transporter (SLC21A6, MRP2) genes involved in drug metabolism and bilirubin clearance.	Bilirubin	168-177	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	89-95
14705859-2	2003	The orphan nuclear receptor CAR (NR1I3 controls phase I (CYP2B, CYP2C, CYP3A), phase II (UGT1A1), and transporter (SLC21A6, MRP2) genes involved in drug metabolism and bilirubin clearance.	Bilirubin	168-177	solute carrier organic anion transporter family member 1B1	Homo sapiens	115-122
14705859-2	2003	The orphan nuclear receptor CAR (NR1I3 controls phase I (CYP2B, CYP2C, CYP3A), phase II (UGT1A1), and transporter (SLC21A6, MRP2) genes involved in drug metabolism and bilirubin clearance.	Bilirubin	168-177	ATP binding cassette subfamily C member 2	Homo sapiens	124-128
14705859-3	2003	Constitutive androstane receptor (CAR) is activated by xenobiotics, such as phenobarbital, but also by toxic endogenous compounds such as bilirubin metabolite(s).	Bilirubin	138-147	nuclear receptor subfamily 1 group I member 3	Homo sapiens	0-32
14705859-3	2003	Constitutive androstane receptor (CAR) is activated by xenobiotics, such as phenobarbital, but also by toxic endogenous compounds such as bilirubin metabolite(s).	Bilirubin	138-147	nuclear receptor subfamily 1 group I member 3	Homo sapiens	34-37
14696449-7	2003	RESULTS: The blood hepatocyte growth factor concentration correlated positively with serum bilirubin (r = 0.556, p &lt; 0.001) level, whereas bile hepatocyte growth factor concentration, hepatocyte growth factor bile/blood ratio, hepatocyte growth factor clearance and daily hepatocyte growth factor output correlated negatively with serum bilirubin level (p = 0.006, &lt; 0.001, &lt; 0.001 and 0.002, respectively).	Bilirubin	91-100	hepatocyte growth factor	Homo sapiens	19-43
14696449-7	2003	RESULTS: The blood hepatocyte growth factor concentration correlated positively with serum bilirubin (r = 0.556, p &lt; 0.001) level, whereas bile hepatocyte growth factor concentration, hepatocyte growth factor bile/blood ratio, hepatocyte growth factor clearance and daily hepatocyte growth factor output correlated negatively with serum bilirubin level (p = 0.006, &lt; 0.001, &lt; 0.001 and 0.002, respectively).	Bilirubin	340-349	hepatocyte growth factor	Homo sapiens	19-43
14703221-8	2003	The mean bilirubin level in G6PD deficient and G6PD normal groups were 22.26 +/- 8.36 and 18.14 +/- 3.85 mg/dl, respectively (p=0.001).	Bilirubin	9-18	glucose-6-phosphate dehydrogenase	Homo sapiens	28-32
14585750-8	2003	In conclusion, our study showed that serum SOD, GPx, catalase, and ceruloplasmin were higher in children with acute bacterial meningitis and serum SOD, GPx, catalase, ceruloplasmin, and total bilirubin levels were increased in children with encephalitis.	Bilirubin	192-201	superoxide dismutase 1	Homo sapiens	43-46
14688229-4	2003	Growth hormone treatment resulted in a decrease in the latency (that gives a quantification of uridine diphosphate glucuronosyltransferase functional state) of the glucuronidation activities towards various substrates (testosterone, androsterone, bilirubin and 4-nitrophenol).	Bilirubin	247-256	gonadotropin releasing hormone receptor	Rattus norvegicus	0-14
14535985-9	2003	RESULTS: Elevated GGT at presentation was found in 21 patients (30%) and was associated with significantly higher serum levels of aspartate transaminase (AST), bilirubin (BIL) and SBA.	Bilirubin	160-169	inactive glutathione hydrolase 2	Homo sapiens	18-21
14535985-9	2003	RESULTS: Elevated GGT at presentation was found in 21 patients (30%) and was associated with significantly higher serum levels of aspartate transaminase (AST), bilirubin (BIL) and SBA.	Bilirubin	171-174	inactive glutathione hydrolase 2	Homo sapiens	18-21
14550264-1	2003	UDP-glucuronosyltransferase form 1A1 (UGT1A1) is the only bilirubin-glucuronidating isoform of this protein, and genetic deficiencies of UGT1A1 cause Crigler-Najjar syndrome, a disorder resulting from nonhemolytic unconjugated hyperbilirubinemia.	Bilirubin	58-67	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-36
14550264-1	2003	UDP-glucuronosyltransferase form 1A1 (UGT1A1) is the only bilirubin-glucuronidating isoform of this protein, and genetic deficiencies of UGT1A1 cause Crigler-Najjar syndrome, a disorder resulting from nonhemolytic unconjugated hyperbilirubinemia.	Bilirubin	58-67	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	38-44
14550264-1	2003	UDP-glucuronosyltransferase form 1A1 (UGT1A1) is the only bilirubin-glucuronidating isoform of this protein, and genetic deficiencies of UGT1A1 cause Crigler-Najjar syndrome, a disorder resulting from nonhemolytic unconjugated hyperbilirubinemia.	Bilirubin	58-67	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	137-143
14550264-2	2003	Here we have focused on the instability of a translocation-deficient UGT1A1 protein, which has been found in patients with Crigler-Najjar type II, to elucidate the molecular basis underlying the deficiency in glucuronidation of bilirubin.	Bilirubin	228-237	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	69-75
14511769-9	2003	FLAP (30 microM) also reversibly inhibited the Mrp2-mediated biliary elimination of bilirubin and bromsulphthalein in Wistar rats by 54% and 51%, respectively, indicating a competition with the elimination of Mrp2-specific substrates.	Bilirubin	84-93	ATP binding cassette subfamily B member 4	Rattus norvegicus	47-51
14511769-10	2003	In summary, we found that FLAP glucuronides are substrates of Mrp2 effectively inhibiting the biliary excretion of bilirubin.	Bilirubin	115-124	ATP binding cassette subfamily B member 4	Rattus norvegicus	62-66
14529832-1	2003	Bilirubin is glucuronidated by bilirubin UDP-glucuronyltransferase (UGT1A1) before biliary excretion.	Bilirubin	0-9	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	68-74
14529832-11	2003	Injection of a lentiviral UGT1A1 vector into third-trimester Gunn rat fetuses corrects the metabolic deficiency and mediates a reduction of serum bilirubin levels that would be therapeutic in humans.	Bilirubin	146-155	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	26-32
12904601-0	2003	Administration of drugs known to inhibit P-glycoprotein increases brain bilirubin and alters the regional distribution of bilirubin in rat brain.	Bilirubin	72-81	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	41-55
12904601-0	2003	Administration of drugs known to inhibit P-glycoprotein increases brain bilirubin and alters the regional distribution of bilirubin in rat brain.	Bilirubin	122-131	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	41-55
12904601-2	2003	P-gp contributes to the blood-brain barrier in limiting the influx and retention of a variety of lipophilic compounds, including unconjugated bilirubin.	Bilirubin	142-151	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	0-4
12904601-4	2003	In this study we proposed that pretreatment with drugs known to inhibit P-gp function in clinically relevant doses would alter the uptake of bilirubin in the brain of 32- to 36-d-old rats.	Bilirubin	141-150	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	72-76
12904601-14	2003	We speculate that drugs known to inhibit P-gp function may increase the risk of bilirubin encephalopathy in the hyperbilirubinemic infant.	Bilirubin	80-89	phosphoglycolate phosphatase	Homo sapiens	41-45
14620509-4	2003	Variations in the expression levels of four different UGT isoforms (UGT1A1, 1A2, 1A5, and 1A6) that are involved in the glucuronication of bilirubin and phenols were determined by comparison with those of an internal standard, beta-actin, which is known to be insensitive to nutritional and hormonal conditions.	Bilirubin	139-148	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	68-74
15086901-1	2004	BACKGROUND: Heme oxygenase-1 (HO-1) catalyzes the conversion of heme to bilirubin, carbon monoxide (CO), and free iron, thus controlling the level of cellular heme.	Bilirubin	72-81	heme oxygenase 1	Homo sapiens	12-28
15086901-1	2004	BACKGROUND: Heme oxygenase-1 (HO-1) catalyzes the conversion of heme to bilirubin, carbon monoxide (CO), and free iron, thus controlling the level of cellular heme.	Bilirubin	72-81	heme oxygenase 1	Homo sapiens	30-34
14977878-1	2004	Biliverdin, a product of heme oxygenase-1 (HO-1) enzymatic action, is converted into bilirubin, which has been considered a waste product in the past.	Bilirubin	85-94	heme oxygenase 1	Homo sapiens	25-41
15083066-10	2004	We identified monoglucuronosyl bilirubin, bisglucuronosyl bilirubin and leukotriene C4 as substrates for both MRP3 and MRP3-ArgHis.	Bilirubin	58-67	ATP binding cassette subfamily B member 4	Homo sapiens	110-114
15083066-10	2004	We identified monoglucuronosyl bilirubin, bisglucuronosyl bilirubin and leukotriene C4 as substrates for both MRP3 and MRP3-ArgHis.	Bilirubin	58-67	ATP binding cassette subfamily B member 4	Homo sapiens	119-123
15083066-10	2004	We identified monoglucuronosyl bilirubin, bisglucuronosyl bilirubin and leukotriene C4 as substrates for both MRP3 and MRP3-ArgHis.	Bilirubin	31-40	ATP binding cassette subfamily B member 4	Homo sapiens	119-123
12927812-3	2003	HO-1 induction was accompanied by a marked increase in catalytic activity of the enzyme as reflected by enhanced formation of both carbon monoxide and bilirubin.	Bilirubin	151-160	heme oxygenase 1	Homo sapiens	0-4
12927819-9	2003	Upregulation of HO-1 ensures the generation of bilirubin and carbon monoxide (CO) in G(0)/G(1) phase to counteract Ang II-mediated oxidative DNA damage.	Bilirubin	47-56	heme oxygenase 1	Homo sapiens	16-20
12927819-9	2003	Upregulation of HO-1 ensures the generation of bilirubin and carbon monoxide (CO) in G(0)/G(1) phase to counteract Ang II-mediated oxidative DNA damage.	Bilirubin	47-56	angiotensinogen	Homo sapiens	115-121
12906872-0	2003	Bilirubin release induced by tumor necrosis factor in combination with galactosamine is toxic to mice.	Bilirubin	0-9	tumor necrosis factor	Mus musculus	29-50
12906872-4	2003	Bilirubin levels are shown to significantly increase after a challenge with TNF/GalN in mice.	Bilirubin	0-9	tumor necrosis factor	Mus musculus	76-79
12906872-5	2003	Pretreatment with a heme oxygenase-1 inhibitor significantly prevents this release in bilirubin and offers significant protection against TNF/GalN-induced lethality.	Bilirubin	86-95	heme oxygenase 1	Mus musculus	20-36
13678532-0	2003	Induction of heme oxygenase-1 in monocytes suppresses angiotensin II-elicited chemotactic activity through inhibition of CCR2: role of bilirubin and carbon monoxide generated by the enzyme.	Bilirubin	135-144	heme oxygenase 1	Homo sapiens	13-29
13678532-2	2003	Heme oxygenase (HO) is a microsomal enzyme that catalyzes the degradation of heme into biliverdin, which is subsequently reduced to bilirubin, free iron, and carbon monoxide, and induction of HO-1 is potentially associated with cellular protection, especially against oxidative insults.	Bilirubin	132-141	heme oxygenase 1	Homo sapiens	192-196
12867491-7	2003	Liver and kidney microsomes displayed similar Km values, but the Vmax in kidney was more than 20-fold less than in liver microsomes, which is suggestive of a significant role for the bilirubin UGT in catalysis of HMR1098, although other UGTs may play a secondary role.	Bilirubin	183-192	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	193-196
13678532-7	2003	Exogenously applied bilirubin and carbon monoxide mimicked the inhibitory effect of HO-1 on the chemotactic response.	Bilirubin	20-29	heme oxygenase 1	Homo sapiens	84-88
13678533-0	2003	Carbon monoxide stimulates mrp2-dependent excretion of bilirubin-IXalpha into bile in the perfused rat liver.	Bilirubin	55-64	ATP binding cassette subfamily C member 2	Rattus norvegicus	27-31
13678533-9	2003	These results suggest that CO stimulates mrp2-dependent excretion of bilirubin-IXalpha through mechanisms involving potassium channels, serving as a cooperator standing behind the heme oxygenase reaction to facilitate hepatic heme detoxification.	Bilirubin	69-78	ATP binding cassette subfamily C member 2	Rattus norvegicus	41-45
12907239-5	2003	We have now used rat CYP1A1 and confirmed with the pure enzyme that increased bilirubin oxidation was caused by the addition of 3,4,3",4"-tetrachlorobiphenyl.	Bilirubin	78-87	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	21-27
12907239-6	2003	CYP1A2 was more active than CYP1A1 at oxidizing bilirubin in presence of NADPH alone and reacted to addition of 3,4,3",4"-tetrachlorobiphenyl with a depression rather than a stimulation of bilirubin oxidation.	Bilirubin	48-57	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
12907239-6	2003	CYP1A2 was more active than CYP1A1 at oxidizing bilirubin in presence of NADPH alone and reacted to addition of 3,4,3",4"-tetrachlorobiphenyl with a depression rather than a stimulation of bilirubin oxidation.	Bilirubin	48-57	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	28-34
12907239-6	2003	CYP1A2 was more active than CYP1A1 at oxidizing bilirubin in presence of NADPH alone and reacted to addition of 3,4,3",4"-tetrachlorobiphenyl with a depression rather than a stimulation of bilirubin oxidation.	Bilirubin	189-198	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
12907239-6	2003	CYP1A2 was more active than CYP1A1 at oxidizing bilirubin in presence of NADPH alone and reacted to addition of 3,4,3",4"-tetrachlorobiphenyl with a depression rather than a stimulation of bilirubin oxidation.	Bilirubin	189-198	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	28-34
12883480-0	2003	Bilirubin rinse: A simple protectant against the rat liver graft injury mimicking heme oxygenase-1 preconditioning.	Bilirubin	0-9	heme oxygenase 1	Rattus norvegicus	82-98
12891549-10	2003	These effects were ascribed to bilirubin, one of the products of HO-1-mediated heme degradation.	Bilirubin	31-40	heme oxygenase 1	Homo sapiens	65-69
12884195-8	2003	There was no significant difference in postoperative serum transaminase levels or prothrombin times; however, anti-HBc-positive donors had greater serum bilirubin levels day 6 (26 v 21 micromol/L; P =.01) and day 7 (22 v 15 micromol/L; P =.004) after surgery.	Bilirubin	153-162	keratin 88, pseudogene	Homo sapiens	115-118
14580148-2	2003	Heme degradation is catalyzed by the two isozymes of heme oxygenase, heme oxygenase-1 (HO-1) and HO-2, eventually yielding biliverdin/bilirubin, CO, and iron.	Bilirubin	134-143	heme oxygenase 1	Homo sapiens	69-85
12859698-10	2003	Cytochrome c levels were correlated with serum bilirubin, alkaline phosphatase, creatinine levels, necroinflammatory score and apoptotic index, but not with serum alanine aminotransferase and synthetic liver function tests.	Bilirubin	47-56	cytochrome c, somatic	Homo sapiens	0-12
12909459-1	2003	Heme oxygenase (HO)-1 catabolizes heme into three products: carbon monoxide (CO), biliverdin (which is rapidly converted to bilirubin) and free iron (which leads to the induction of ferritin, an iron-binding protein).	Bilirubin	124-133	heme oxygenase 1	Homo sapiens	0-21
14580148-2	2003	Heme degradation is catalyzed by the two isozymes of heme oxygenase, heme oxygenase-1 (HO-1) and HO-2, eventually yielding biliverdin/bilirubin, CO, and iron.	Bilirubin	134-143	heme oxygenase 1	Homo sapiens	87-91
14580148-2	2003	Heme degradation is catalyzed by the two isozymes of heme oxygenase, heme oxygenase-1 (HO-1) and HO-2, eventually yielding biliverdin/bilirubin, CO, and iron.	Bilirubin	134-143	heme oxygenase 2	Homo sapiens	97-101
14505549-11	2003	8 hours after drug administration the level of serum ALT and total bilirubin (TBil) remarkably increased [(560.66 +/- 60.20) U/L and (163.66 +/- 34.51) micro mol/L, respectively, that of normal control was (23.56 +/- 8.03) U/L and (14.90 +/- 4.80) micro mol/L, respectively] and the expression of caspase-3 reached the peak.	Bilirubin	78-82	caspase 3	Mus musculus	297-306
14505549-12	2003	12 hours after drug administration, hepatocyte apoptosis and necrosis coexisted, and the level of serum ALT and TBil reached a peak [(668.30 +/- 78.69) U/L and (203.17 +/- 19.92) micro mol/L, respectively] whereas the expression of caspase-3 already decreased.	Bilirubin	112-116	caspase 3	Mus musculus	232-241
14714862-12	2003	Serum alkaline phosphatase and total bilirubin were also increased by both moderate and high dose level of treatments in MECR and MECO treated mice respectively.	Bilirubin	37-46	mitochondrial trans-2-enoyl-CoA reductase	Mus musculus	121-125
12690112-0	2003	Heme oxygenase inhibits human airway smooth muscle proliferation via a bilirubin-dependent modulation of ERK1/2 phosphorylation.	Bilirubin	71-80	mitogen-activated protein kinase 3	Homo sapiens	105-111
12690112-5	2003	By contrast, bilirubin (1 microm) and the antioxidant N-acetyl-cysteine (1 mm) significantly reduced mitogen-induced cell proliferation, ROS production, and ERK1/2 phosphorylation.	Bilirubin	13-22	mitogen-activated protein kinase 3	Homo sapiens	157-163
12690112-8	2003	In conclusion, this study provides evidence for an antiproliferative effect of the HO pathway in ASM in vitro and in vivo through a bilirubin-mediated redox modulation of phosphorylation of ERK1/2.	Bilirubin	132-141	mitogen-activated protein kinase 3	Homo sapiens	190-196
12818378-3	2003	UGT activity toward bilirubin, ethynylestradiol and p-nitrophenol was assayed in native and activated microsomes.	Bilirubin	20-29	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	0-3
12818378-7	2003	Western blot analysis revealed increased levels of UGT1A1 and 1A5 (bilirubin and 3-OH ethynylestradiol conjugation), and 2B1 (17 beta-OH ethynylestradiol conjugation).	Bilirubin	67-76	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	51-65
14515040-8	2003	In patients with LC (regardless of having HCC), the activities of MMP-2 correlated with total bilirubin (r=0.323, p=0.048) and Child-Pugh score (r=0.414, p=0.012).	Bilirubin	94-103	matrix metallopeptidase 2	Homo sapiens	66-71
12801966-8	2003	Elevated TNF levels (&gt;28 pg/mg protein) in cirrhotics were associated with a higher Child-Pugh score, the antecedent of ascites, a lower prothrombin rate, and higher bilirubin and blood TNF levels.	Bilirubin	169-178	tumor necrosis factor	Homo sapiens	9-12
12814968-4	2003	In wild-type mice, PCN treatment significantly increased UGT activities toward bilirubin, 1-naphthol, chloramphenicol, thyroxine, and triiodothyronine.	Bilirubin	79-88	solute carrier family 35 (UDP-galactose transporter), member A2	Mus musculus	57-60
12814968-7	2003	In agreement with the above findings, mRNA levels of mouse Ugt1a1 and Ugt1a9, which are involved in the glucuronidation of bilirubin and phenolic compounds, were increased about 100% in wild-type mice following PCN treatment, whereas the expression of Ugt1a2, 1a6, and 2b5 was not affected.	Bilirubin	123-132	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	59-65
12814968-7	2003	In agreement with the above findings, mRNA levels of mouse Ugt1a1 and Ugt1a9, which are involved in the glucuronidation of bilirubin and phenolic compounds, were increased about 100% in wild-type mice following PCN treatment, whereas the expression of Ugt1a2, 1a6, and 2b5 was not affected.	Bilirubin	123-132	UDP glucuronosyltransferase 1 family, polypeptide A9	Mus musculus	70-76
12814968-7	2003	In agreement with the above findings, mRNA levels of mouse Ugt1a1 and Ugt1a9, which are involved in the glucuronidation of bilirubin and phenolic compounds, were increased about 100% in wild-type mice following PCN treatment, whereas the expression of Ugt1a2, 1a6, and 2b5 was not affected.	Bilirubin	123-132	UDP glucuronosyltransferase 1 family, polypeptide A2	Mus musculus	252-258
12782150-2	2003	We previously reported that addition of unconjugated bilirubin (UCB), which is deconjugated by beta-glucuronidase in infected bile, could enhance cholesterol crystal formation in supersaturated model bile (MB).	Bilirubin	53-62	glucuronidase, beta	Rattus norvegicus	95-113
12829997-7	2003	WT1 mRNA abundance correlated inversely with prothrombin time (P =.04) and directly with serum bilirubin (P =.002) and with the MELD score (P =.001) of disease severity.	Bilirubin	95-104	WT1 transcription factor	Rattus norvegicus	0-3
12795759-6	2003	RESULTS: Injection of CCl4 was followed by a marked increase in serum alanine aminotranferase (ALT) level (CCl4, 1630.6 +/- 606.8 IU/L; olive oil, 21.0 +/- 2.6 IU/L; P &lt; 0.001), lactate dehydrogenase (LDH) level (CCl4, 5068.0 +/- 2956.4 IU/L; olive oil, 203.6 +/- 30.5 IU/L; P &lt; 0.005), and total bilirubin (TB) level (CCl4, 0.88 +/- 0.48 mg/dL; olive oil, 0.37 +/- 0.05 mg/dL; P &lt; 0.01), whereas in the edaravone-treated rats, the ALT (119.4 +/- 113.5 IU/L, P &lt; 0.001), LDH (369.7 +/- 288.2 IU/L, P &lt; 0.005), and TB values (0.29 +/- 0.16 mg/dL, P &lt; 0.01) were significantly decreased.	Bilirubin	303-312	C-C motif chemokine ligand 4	Rattus norvegicus	22-26
12795759-6	2003	RESULTS: Injection of CCl4 was followed by a marked increase in serum alanine aminotranferase (ALT) level (CCl4, 1630.6 +/- 606.8 IU/L; olive oil, 21.0 +/- 2.6 IU/L; P &lt; 0.001), lactate dehydrogenase (LDH) level (CCl4, 5068.0 +/- 2956.4 IU/L; olive oil, 203.6 +/- 30.5 IU/L; P &lt; 0.005), and total bilirubin (TB) level (CCl4, 0.88 +/- 0.48 mg/dL; olive oil, 0.37 +/- 0.05 mg/dL; P &lt; 0.01), whereas in the edaravone-treated rats, the ALT (119.4 +/- 113.5 IU/L, P &lt; 0.001), LDH (369.7 +/- 288.2 IU/L, P &lt; 0.005), and TB values (0.29 +/- 0.16 mg/dL, P &lt; 0.01) were significantly decreased.	Bilirubin	314-316	C-C motif chemokine ligand 4	Rattus norvegicus	22-26
12795759-6	2003	RESULTS: Injection of CCl4 was followed by a marked increase in serum alanine aminotranferase (ALT) level (CCl4, 1630.6 +/- 606.8 IU/L; olive oil, 21.0 +/- 2.6 IU/L; P &lt; 0.001), lactate dehydrogenase (LDH) level (CCl4, 5068.0 +/- 2956.4 IU/L; olive oil, 203.6 +/- 30.5 IU/L; P &lt; 0.005), and total bilirubin (TB) level (CCl4, 0.88 +/- 0.48 mg/dL; olive oil, 0.37 +/- 0.05 mg/dL; P &lt; 0.01), whereas in the edaravone-treated rats, the ALT (119.4 +/- 113.5 IU/L, P &lt; 0.001), LDH (369.7 +/- 288.2 IU/L, P &lt; 0.005), and TB values (0.29 +/- 0.16 mg/dL, P &lt; 0.01) were significantly decreased.	Bilirubin	529-531	C-C motif chemokine ligand 4	Rattus norvegicus	22-26
12782150-6	2003	Compared with beta-glucuronidase-free bile, (1) beta-glucuronidase-containing bile showed a significant increase of the UCB/total bilirubin ratio, (2) as well as a significantly longer nucleation time (96+/-17.0 vs. 114+/-20.0) and fewer cholesterol crystals.	Bilirubin	130-139	glucuronidase, beta	Rattus norvegicus	48-66
12622689-1	2003	NO potently up-regulates vascular haem oxygenase-1 (HO-1), an inducible defensive protein that degrades haem to CO, iron and the antioxidant bilirubin.	Bilirubin	141-150	heme oxygenase 1	Homo sapiens	34-50
12670950-3	2003	276, 9626-9630) suggests that human OATP2 (SLC21A6), also known as OATP-C and LST1, mediates hepatic bilirubin transport.	Bilirubin	101-110	solute carrier organic anion transporter family member 1B1	Homo sapiens	36-41
12670950-3	2003	276, 9626-9630) suggests that human OATP2 (SLC21A6), also known as OATP-C and LST1, mediates hepatic bilirubin transport.	Bilirubin	101-110	solute carrier organic anion transporter family member 1B1	Homo sapiens	43-50
12670950-3	2003	276, 9626-9630) suggests that human OATP2 (SLC21A6), also known as OATP-C and LST1, mediates hepatic bilirubin transport.	Bilirubin	101-110	solute carrier organic anion transporter family member 1B1	Homo sapiens	67-73
12670950-3	2003	276, 9626-9630) suggests that human OATP2 (SLC21A6), also known as OATP-C and LST1, mediates hepatic bilirubin transport.	Bilirubin	101-110	leukocyte specific transcript 1	Homo sapiens	78-82
12670950-6	2003	This assay was then used to quantify bilirubin transport by HeLa cells that had been stably transfected with OATP2 under regulation of a metallothionein promoter.	Bilirubin	37-46	solute carrier organic anion transporter family member 1B1	Homo sapiens	109-114
12622689-1	2003	NO potently up-regulates vascular haem oxygenase-1 (HO-1), an inducible defensive protein that degrades haem to CO, iron and the antioxidant bilirubin.	Bilirubin	141-150	heme oxygenase 1	Homo sapiens	52-56
12622689-5	2003	A role for haem metabolites in modulating HO-1 expression by NO was assessed by exposing cells to SNAP, SNP or DETA/NO in medium derived from cells treated with haemin, which contained increased bilirubin levels.	Bilirubin	195-204	heme oxygenase 1	Homo sapiens	42-46
12868677-13	2003	IL-6 levels appeared to correlate positively with bilirubin and gamma-GT levels and negatively with the degree of acidosis.	Bilirubin	50-59	interleukin 6	Homo sapiens	0-4
12814358-16	2003	Furthermore, biliverdin and bilirubin, products of HO-1 enzymatic activity on heme, protected HT22 cells from oxidative glutamate toxicity.	Bilirubin	28-37	heme oxygenase 1	Mus musculus	51-55
12814358-17	2003	These results, together with our previous results, suggest that NEPP11 activates the expression of HO-1 and that HO-1 produces biliverdin and bilirubin, which result in the inhibition of neuronal death induced by oxidative stress.	Bilirubin	142-151	heme oxygenase 1	Mus musculus	113-117
12753084-0	2003	Heme oxygenase-1 and heme oxygenase-2 have distinct roles in the proliferation and survival of olfactory receptor neurons mediated by cGMP and bilirubin, respectively.	Bilirubin	143-152	heme oxygenase 1	Mus musculus	0-37
12700418-0	2003	Synergistic role of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7alpha-hydroxylase in the pathogenesis of manganese-bilirubin-induced cholestasis in rats.	Bilirubin	136-145	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	20-67
12777582-9	2003	DHTR/H syndrome was defined as the abrupt onset of signs and symptoms of accelerated hemolysis evidenced by an unexplained fall in Hb, elevated lactic dehydrogenase, elevated bilirubin above baseline, and hemoglobinuria, all occurring between 4 and 10 days after an RBC transfusion.	Bilirubin	175-184	androgen receptor	Homo sapiens	0-4
12743361-1	2003	Human serum albumin (HSA) is the major protein component of blood plasma and serves as a transporter for thyroxine and other hydrophobic compounds such as fatty acids and bilirubin.	Bilirubin	171-180	albumin	Homo sapiens	6-25
12709566-2	2003	Although the mechanisms involved in this cytoprotection are largely unknown, HO-1 and its enzymatic products, carbon monoxide and bilirubin, downregulate the inflammatory response by either attenuating the expression of adhesion molecules and thus inhibiting leukocyte recruitment or by repressing the induction of cytokines and chemokines.	Bilirubin	130-139	heme oxygenase 1	Mus musculus	77-81
12695347-7	2003	The etoposide glucuronidation in pooled human liver microsomes was inhibited by bilirubin (IC(50) = 31.7 microM) and estradiol (IC(50) = 34 microM) as typical substrates for UGT1A1.	Bilirubin	80-89	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	174-180
12839286-8	2003	CONCLUSION: In a population of northern European descent, other genetic factors than gender and ABO blood type were significant for the plasma bilirubin concentration in healthy infants.	Bilirubin	143-152	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	96-99
12568656-0	2003	Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin.	Bilirubin	149-158	solute carrier organic anion transporter family member 1A2	Homo sapiens	49-55
12568656-0	2003	Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin.	Bilirubin	149-158	solute carrier organic anion transporter family member 1B1	Homo sapiens	57-63
12568656-0	2003	Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin.	Bilirubin	149-158	solute carrier organic anion transporter family member 1B3	Homo sapiens	68-74
12709571-4	2003	The downregulation of HO-1 expression may reduce energy expenditure and local production of carbon monoxide, iron, and bilirubin and transiently increase intracellular heme pool.	Bilirubin	119-128	heme oxygenase 1	Homo sapiens	22-26
12717398-7	2003	Concurrent with an increase in the serum level of fibrinogen, transaminase levels declined significantly during treatment period, while bilirubin levels continued to drop for up to 20 days after the initiation of treatment (P &lt;.05).	Bilirubin	136-145	fibrinogen beta chain	Homo sapiens	50-60
12709581-6	2003	Elevation of HO-1 protein was accompanied by a marked increase in catalytic activity of the enzyme as reflected by enhanced formation of both carbon monoxide and the endogenous antioxidant, bilirubin.	Bilirubin	190-199	heme oxygenase 1	Homo sapiens	13-17
12709585-2	2003	Although most of the monocyte-derived cytokines exhibit proinflammatory functions in vivo, heme oxygenase-1 (HO-1), an inducible heme-degrading enzyme, exerts potent anti-inflammatory effect through production of carbon monoxide and bilirubin.	Bilirubin	233-242	heme oxygenase 1	Homo sapiens	91-107
12709585-2	2003	Although most of the monocyte-derived cytokines exhibit proinflammatory functions in vivo, heme oxygenase-1 (HO-1), an inducible heme-degrading enzyme, exerts potent anti-inflammatory effect through production of carbon monoxide and bilirubin.	Bilirubin	233-242	heme oxygenase 1	Homo sapiens	109-113
12709592-8	2003	HO-1 activity was determined by the ability of the enzyme to generate bilirubin from hemin.	Bilirubin	70-79	heme oxygenase 1	Homo sapiens	0-4
12566446-1	2003	UDP-glucuronosyltransferase 1A1 (UGT1A1) plays an important physiological role by contributing to the metabolism of endogenous substances such as bilirubin in addition to xenobiotics and drugs.	Bilirubin	146-155	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-31
12566446-1	2003	UDP-glucuronosyltransferase 1A1 (UGT1A1) plays an important physiological role by contributing to the metabolism of endogenous substances such as bilirubin in addition to xenobiotics and drugs.	Bilirubin	146-155	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	33-39
12667932-2	2003	Delta bilirubin, containing intact human serum albumin (HSA), was digested with trypsin and the peptide fragments were monitored at 436 nm, but no predominant peaks were detected indicating the instability of the digested peptides containing bilirubin-related compounds.	Bilirubin	6-15	albumin	Homo sapiens	41-54
12578834-4	2003	The effect of NGF was mimicked by induction of HO-1 expression with CoCl(2); by treatment with bilirubin, an end product of heme catabolism; and by infection with a retroviral expression vector for human HO-1.	Bilirubin	95-104	nerve growth factor	Homo sapiens	14-17
12678694-6	2003	HO1-mediated metabolism of heme groups released from NO-damaged proteins leads to a change in the levels of redox-active iron and a release of carbon monoxide (CO) and bilirubin, all of which have been implicated in cellular resistance to oxidative stress.	Bilirubin	168-177	heme oxygenase 1	Homo sapiens	0-3
12618960-7	2003	UGT1A1 catalyzes the conjugation of bilirubin with glucuronic acid and thus enhances bilirubin elimination; therefore, it is an important candidate gene for serum bilirubin.	Bilirubin	36-45	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
12618960-7	2003	UGT1A1 catalyzes the conjugation of bilirubin with glucuronic acid and thus enhances bilirubin elimination; therefore, it is an important candidate gene for serum bilirubin.	Bilirubin	85-94	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
12618960-7	2003	UGT1A1 catalyzes the conjugation of bilirubin with glucuronic acid and thus enhances bilirubin elimination; therefore, it is an important candidate gene for serum bilirubin.	Bilirubin	85-94	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
12618960-10	2003	Our findings suggest that UGT1A1 may be a major gene controlling serum bilirubin levels in the population.	Bilirubin	71-80	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	26-32
12644704-4	2003	Because the nuclear hormone receptor constitutive androstane receptor (CAR) mediates hepatic effects of this xenobiotic inducer, we hypothesized that CAR could be a regulator of bilirubin clearance.	Bilirubin	178-187	nuclear receptor subfamily 1, group I, member 3	Mus musculus	37-69
12644700-3	2003	In this report, we show that both receptors can induce specific UGT1A isoforms including those involved in estrogen, thyroxin, bilirubin, and carcinogen metabolism.	Bilirubin	127-136	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	64-69
12677174-0	2003	UGT1A promoter polymorphisms influence bilirubin response to hydroxyurea therapy in sickle cell anemia.	Bilirubin	39-48	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	0-5
12677174-2	2003	We recently reported that a promoter polymorphism in the uridine diphosphoglucuronate glucuronosyltransferase 1A (UGT1A) gene affects steady-state bilirubin levels and the incidence of gallstones in children with SCA.	Bilirubin	147-156	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	57-112
12644704-4	2003	Because the nuclear hormone receptor constitutive androstane receptor (CAR) mediates hepatic effects of this xenobiotic inducer, we hypothesized that CAR could be a regulator of bilirubin clearance.	Bilirubin	178-187	nuclear receptor subfamily 1, group I, member 3	Mus musculus	71-74
12677174-2	2003	We recently reported that a promoter polymorphism in the uridine diphosphoglucuronate glucuronosyltransferase 1A (UGT1A) gene affects steady-state bilirubin levels and the incidence of gallstones in children with SCA.	Bilirubin	147-156	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	114-119
12677174-5	2003	Children with the wild-type 6/6 UGT1A genotype demonstrated normalized bilirubin levels with hydroxyurea therapy, but children with the heterozygous 6/7 or abnormal 7/7 genotypes did not.	Bilirubin	71-80	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	32-37
12644700-4	2003	Transgenic mice expressing a constitutively active form of human PXR show markedly increased UGT activity toward steroid, heme, and carcinogens, enhanced bilirubin clearance, as well as massively increased steroid clearance.	Bilirubin	154-163	nuclear receptor subfamily 1 group I member 2	Homo sapiens	65-68
12644704-0	2003	Induction of bilirubin clearance by the constitutive androstane receptor (CAR).	Bilirubin	13-22	nuclear receptor subfamily 1, group I, member 3	Mus musculus	40-72
12644704-4	2003	Because the nuclear hormone receptor constitutive androstane receptor (CAR) mediates hepatic effects of this xenobiotic inducer, we hypothesized that CAR could be a regulator of bilirubin clearance.	Bilirubin	178-187	nuclear receptor subfamily 1, group I, member 3	Mus musculus	150-153
12644704-0	2003	Induction of bilirubin clearance by the constitutive androstane receptor (CAR).	Bilirubin	13-22	nuclear receptor subfamily 1, group I, member 3	Mus musculus	74-77
12677174-7	2003	These data indicate the UGT1A promoter polymorphism is a powerful nonglobin genetic modifier in SCA that influences serum bilirubin both at baseline and on hydroxyurea therapy.	Bilirubin	122-131	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	24-29
12644704-5	2003	Activation of the nuclear hormone receptor CAR increases hepatic expression of each of five components of the bilirubin-clearance pathway.	Bilirubin	110-119	nuclear receptor subfamily 1, group I, member 3	Mus musculus	43-46
12644704-8	2003	Bilirubin itself can also activate CAR, and mice lacking CAR are defective in clearing chronically elevated bilirubin levels.	Bilirubin	0-9	nuclear receptor subfamily 1, group I, member 3	Mus musculus	35-38
12644704-8	2003	Bilirubin itself can also activate CAR, and mice lacking CAR are defective in clearing chronically elevated bilirubin levels.	Bilirubin	108-117	nuclear receptor subfamily 1, group I, member 3	Mus musculus	57-60
12644704-10	2003	We conclude that CAR directs a protective response to elevated bilirubin levels and suggest that a functional deficit of CAR activity may contribute to neonatal jaundice.	Bilirubin	63-72	nuclear receptor subfamily 1, group I, member 3	Mus musculus	17-20
12511571-1	2003	Heme oxygenase 1 (HO-1) catalyzes heme breakdown, eventually releasing iron, carbon monoxide, and bilirubin IXalpha.	Bilirubin	98-107	heme oxygenase 1	Homo sapiens	0-16
12646172-2	2003	Likewise, bilirubin-UGT1A1 expressed in COS-1 cells was inhibited by curcumin and calphostin-C.	Bilirubin	10-19	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	20-26
12650931-0	2003	A new ligand for an old lipocalin: induced circular dichroism spectra reveal binding of bilirubin to bovine beta-lactoglobulin.	Bilirubin	88-97	beta-lactoglobulin	Bos taurus	108-126
12650931-1	2003	This study reports that bilirubin-bovine beta-lactoglobulin (BLG) complexes exhibit very characteristic induced circular dichroism (CD) spectra in the visible absorption region.	Bilirubin	24-33	beta-lactoglobulin	Bos taurus	41-59
12650931-1	2003	This study reports that bilirubin-bovine beta-lactoglobulin (BLG) complexes exhibit very characteristic induced circular dichroism (CD) spectra in the visible absorption region.	Bilirubin	24-33	beta-lactoglobulin	Bos taurus	61-64
12650931-2	2003	Due to intramolecular chiral exciton coupling between the dipyrrinone chromophores, the long-wavelength negative and short-wavelength positive CD bands clearly prove that a single bilirubin molecule binds to BLG in a left-handed helical conformation (in pH 7.4 phosphate buffer Deltaepsilon(min) is -54 M(-1) cm(-1) at 467 nm and Deltaepsilon(max) is +48.5 M(-1) cm(-1) at 412 nm).	Bilirubin	180-189	beta-lactoglobulin	Bos taurus	208-211
12650931-4	2003	Vanishing CD activity obtained upon titration of the complex with palmitic acid known to bind in the hydrophobic cavity of BLG indicates bilirubin to be bound at the open end mouth of the beta-barrel.	Bilirubin	137-146	beta-lactoglobulin	Bos taurus	123-126
12675340-1	2003	Poly(vinyl chloride) membrane sensors for Ca(II) ions were constructed based on bilirubin (1,3,6,7-tetramethyl-4,5-dicarboxyethy-2,8-divinyl-[b-13]-dihydrobilenone) as a neutral carrier in the presence of various plasticizers (o-nitrophenyloctyl ether, dioctyl phethalate and dibutyl sebacate), which were used as solvent mediators to incorporate the carrier into the membranes.	Bilirubin	80-89	carbonic anhydrase 2	Homo sapiens	42-48
12899737-6	2003	The UGT1A subfamily (genes located on chromosome 2) glucuronidates bilirubin, thyroid hormones, and some medications.	Bilirubin	67-76	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	4-9
12633758-8	2003	CONCLUSION: The ABL 700 series gave comparable results for lactate, bilirubin and hemoglobin F with laboratory methods and may be used in patient care.	Bilirubin	68-77	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	16-19