PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 23010496-4 2012 The present study uses an electrophoretic redox Western blot method to analyze the oxidation state of Trx1 in vivo separating the protein-changed isoform following alkylation with iodoacetic acid in 8M urea. Iodoacetic Acid 180-195 thioredoxin Homo sapiens 102-106 22272053-2 2011 In the present study, expression of VEGF in the articular cartilage was determined in three different OA models: medial meniscectomy and monoiodoacetate (MIA) injection in rats and age-associated spontaneous joint cartilage destruction in guinea pigs. Iodoacetic Acid 137-152 vascular endothelial growth factor A Rattus norvegicus 36-40 21297031-1 2011 We investigated whether factors released from mouse embryonic stem (ES) cells primed with and without transforming growth factor (TGF)-beta2 inhibit iodoacetic acid (IAA)- and H(2)O(2)-induced apoptosis in the cell culture system as well as after transplantation in the infarcted heart. Iodoacetic Acid 166-169 transforming growth factor, beta 2 Mus musculus 102-140 20356026-1 2010 The chemistry of 2-iodoacetic acid on Cu(100) has been studied by a combination of reflection-absorption infrared spectroscopy (RAIRS), X-ray photoelectron spectroscopy (XPS), temperature-programmed reaction/desorption (TPR/D), and theoretical calculations based on density functional theory for the optimized intermediate structures. Iodoacetic Acid 17-34 translocated promoter region, nuclear basket protein Homo sapiens 220-223 20621685-1 2010 The TRPV1 antagonist A-995662 demonstrates analgesic efficacy in monoiodoacetate-induced osteoarthritic (OA) pain in rat, and repeated dosing results in increased in vivo potency and a prolonged duration of action. Iodoacetic Acid 65-80 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-9 19923925-7 2010 Third, inhibition of glycolysis with iodoacetic acid reduced ATP levels at a much faster rate in H-Ras(Q61L) transformed cells than in the vector control cells. Iodoacetic Acid 37-52 Harvey rat sarcoma virus oncogene Mus musculus 97-102 20185307-4 2010 The labeled GDH was successfully subjected to S-pyridylethylation keeping the biotin tag intact, and then was easily released from streptavidin matrix with high purity via iodoacetic acid-mediated alkylation under mild condition at pH 5.0. Iodoacetic Acid 172-187 glutamate dehydrogenase 1 Homo sapiens 12-15 21048303-3 2010 We examined the reactivity of purified rat prostate AdoMetDC to the SH-reagent iodoacetic acid (IAA) and its susceptibility to proteolysis in the presence or absence of putrescine using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). Iodoacetic Acid 79-94 adenosylmethionine decarboxylase 1 Rattus norvegicus 52-60 21048303-3 2010 We examined the reactivity of purified rat prostate AdoMetDC to the SH-reagent iodoacetic acid (IAA) and its susceptibility to proteolysis in the presence or absence of putrescine using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). Iodoacetic Acid 96-99 adenosylmethionine decarboxylase 1 Rattus norvegicus 52-60 21048303-4 2010 The activity of AdoMetDC treated with IAA in the absence of putrescine was reduced, but about 80% of its activity remained after treatment with IAA in the presence of putrescine. Iodoacetic Acid 38-41 adenosylmethionine decarboxylase 1 Rattus norvegicus 16-24 21048303-4 2010 The activity of AdoMetDC treated with IAA in the absence of putrescine was reduced, but about 80% of its activity remained after treatment with IAA in the presence of putrescine. Iodoacetic Acid 144-147 adenosylmethionine decarboxylase 1 Rattus norvegicus 16-24 21048303-5 2010 In the presence of putrescine, IAA incorporation was 1.9 mol IAA/mol of AdoMetDC alpha-subunit, while there was no incorporation of IAA in the beta-subunit of AdoMetDC. Iodoacetic Acid 31-34 adenosylmethionine decarboxylase 1 Rattus norvegicus 72-80 18470871-2 2008 The method was applied to model reaction mixtures in the study of the formation of iodoacetic acid after chlorinated tap water was boiled in the presence of potassium iodide or iodized table salt. Iodoacetic Acid 83-98 nuclear RNA export factor 1 Homo sapiens 117-120 12882768-7 2003 Recombinant Trx1 was sensitive to iodoacetic acid but showed strong resistance to oxidation (0.1 mM H(2)O(2)) at its approximate physiological protein level. Iodoacetic Acid 34-49 thioredoxin Homo sapiens 12-16 18699993-9 2008 In the monoiodoacetic acid-induced arthritis model, anti-FGF8 antibody reduced ECM release into the synovial cavity. Iodoacetic Acid 7-26 fibroblast growth factor 8 Rattus norvegicus 57-61 16394269-4 2006 To this end, we have developed a vector carrying HSP70/GFP, and transduced chondrocytes were thus more resistant to cell death induced by mono-iodoacetate (MIA). Iodoacetic Acid 138-154 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 49-54 15933002-11 2005 To confirm the involvement of glycolysis in the glucose effect, iodoacetic acid was used to inhibit glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity. Iodoacetic Acid 64-79 type I glyceraldehyde-3-phosphate dehydrogenase Lactobacillus rhamnosus GG 100-140 15933002-11 2005 To confirm the involvement of glycolysis in the glucose effect, iodoacetic acid was used to inhibit glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity. Iodoacetic Acid 64-79 type I glyceraldehyde-3-phosphate dehydrogenase Lactobacillus rhamnosus GG 142-147 15794752-2 2005 The frequency of R phases was significantly inhibited by oligomycin and aurovertin (mitochondrial ATP synthase inhibitors), rotenone (mitochondrial complex I inhibitor) and iodoacetic acid (inhibitor of the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase). Iodoacetic Acid 173-188 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 225-265 18442439-8 2008 Muller cell stalks became immunoreactive for glial fibrillary acidic protein (GFAP) even in IAA-treated retinae that had no signs of cell loss, indicating a response of the retina to the toxin. Iodoacetic Acid 92-95 glial fibrillary acidic protein Oryctolagus cuniculus 45-76 18442439-8 2008 Muller cell stalks became immunoreactive for glial fibrillary acidic protein (GFAP) even in IAA-treated retinae that had no signs of cell loss, indicating a response of the retina to the toxin. Iodoacetic Acid 92-95 glial fibrillary acidic protein Oryctolagus cuniculus 78-82 16982516-7 2006 The concentration of iodoacetic acid in tap water samples boiled with 2 g l-1 of iodized table salt was found to be in the 1.5 microg l-1 range, whilst the concentration of chloroiodoacetic acid was estimated to be three to five times lower. Iodoacetic Acid 21-36 nuclear RNA export factor 1 Homo sapiens 40-43 16598858-2 2006 Mitochondrial cytochrome c also reacts with 5,5"-dithio-bis-(2-nitrobenzoic acid) and 1-chloro-2,4-dinitrobenzene in a manner prevented with NEM or iodoacetic acid (IAA). Iodoacetic Acid 148-163 cytochrome c, somatic Homo sapiens 14-26 16598858-2 2006 Mitochondrial cytochrome c also reacts with 5,5"-dithio-bis-(2-nitrobenzoic acid) and 1-chloro-2,4-dinitrobenzene in a manner prevented with NEM or iodoacetic acid (IAA). Iodoacetic Acid 165-168 cytochrome c, somatic Homo sapiens 14-26 16570611-2 2006 Previously we demonstrated that iodoacetic acid was the most cytotoxic and genotoxic DBP analyzed in a mammalian cell system. Iodoacetic Acid 32-47 D-box binding PAR bZIP transcription factor Homo sapiens 85-88 16570611-4 2006 The involvement of oxidative stress in the toxicity of iodoacetic acid was analyzed with the antioxidants catalase and butylated hydroxyanisole (BHA). Iodoacetic Acid 55-70 catalase Cricetulus griseus 106-114 16570611-9 2006 However, in S. typhimurium, BHA or catalase reduced the mutagenicity of iodoacetic acid by 33.5 and 26.8%, respectively. Iodoacetic Acid 72-87 catalase Cricetulus griseus 35-43 16570611-10 2006 Likewise, BHA or catalase reduced iodoacetic acid induced genomic DNA damage by 86.5 and 42%, respectively. Iodoacetic Acid 34-49 catalase Cricetulus griseus 17-25 15299283-1 2004 The aim of this work was to determine whether Hsp70 overexpression via proteasome inhibitor MG132 was able to protect chondrocytes towards mono-iodoacetate (MIA) cytotoxicity both in vitro and in vivo. Iodoacetic Acid 139-155 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 46-51 14550284-3 2003 The covalent modification results clearly indicate the ability of NEM and iodoacetic acid (IAA) to potently inhibit the ATPase activity of N-terminal NBD. Iodoacetic Acid 74-89 dynein axonemal heavy chain 8 Homo sapiens 120-126 14550284-3 2003 The covalent modification results clearly indicate the ability of NEM and iodoacetic acid (IAA) to potently inhibit the ATPase activity of N-terminal NBD. Iodoacetic Acid 91-94 dynein axonemal heavy chain 8 Homo sapiens 120-126 12732513-4 2003 Monoiodoacetate and EDTA both inhibited the PghP activity, but Zn(2+) or Mn(2+) ions fully restored the enzyme activity inhibited by the chelator, suggesting that a cysteine residue(s) and these metal ions participate in the catalytic mechanism of the enzyme. Iodoacetic Acid 0-15 poly-gamma-glutamate hydrolase of phage (PghP) Bacillus phage phiNIT1 44-48 11677264-2 2001 In the present study we employed iodoacetic acid (IAA), an inhibitor of glyceraldehyde-3-phosphate dehydrogenase, to test the hypothesis that inhibition of glycolysis can protect neurons. Iodoacetic Acid 50-53 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 72-112 12359716-9 2002 Pretreatment with the glycolytic inhibitor iodoacetic acid caused a remarkable reduction of Na,K-ATPase activity, whereas pretreatment with the oxidative inhibitor carbonyl cyanide m-chlorophenylhydrazone caused no detectable changes, suggesting that the phosphorylated cofilin is involved in feeding glycolytic fuel for Na,K-ATPase activity. Iodoacetic Acid 43-58 cofilin 1 Homo sapiens 270-277 12014580-6 2002 Since 1 mM allopurinol entirely inhibited the allantoin generation, xanthine dehydrogenase/oxidase was found to play a key role in the purine catabolism in IAA-treated C2C12 myotubes. Iodoacetic Acid 156-159 xanthine dehydrogenase Mus musculus 68-98 11697851-0 2001 Chemical modification of transducin with iodoacetic acid: transducin-alpha carboxymethylated at Cys(347) allows transducin binding to Light-activated rhodopsin but prevents its release in the presence of GTP. Iodoacetic Acid 41-56 G protein subunit alpha z Homo sapiens 58-74 11697851-0 2001 Chemical modification of transducin with iodoacetic acid: transducin-alpha carboxymethylated at Cys(347) allows transducin binding to Light-activated rhodopsin but prevents its release in the presence of GTP. Iodoacetic Acid 41-56 rhodopsin Homo sapiens 150-159 11677264-6 2001 Levels of the stress heat-shock proteins HSP70 and HSP90, and of the anti-apoptotic protein Bcl-2, were increased in neurons exposed to IAA. Iodoacetic Acid 136-139 heat shock protein family A (Hsp70) member 4 Homo sapiens 41-46 11677264-6 2001 Levels of the stress heat-shock proteins HSP70 and HSP90, and of the anti-apoptotic protein Bcl-2, were increased in neurons exposed to IAA. Iodoacetic Acid 136-139 heat shock protein 90 alpha family class A member 1 Homo sapiens 51-56 11677264-6 2001 Levels of the stress heat-shock proteins HSP70 and HSP90, and of the anti-apoptotic protein Bcl-2, were increased in neurons exposed to IAA. Iodoacetic Acid 136-139 BCL2 apoptosis regulator Homo sapiens 92-97 8761470-6 1996 We found that oxidizing agents, such as H2O2 and diamide, as well as alkylating agents, such as iodoacetic acid, abolished, in vitro, the HSF-DNA-binding activity induced by HS in vivo. Iodoacetic Acid 96-111 interleukin 6 Homo sapiens 138-141 11170581-3 2001 Free cysteine thiol groups of keratin extracted from chicken feathers were partially carboxymethylated with iodoacetic acid (25-76% cysteine modification). Iodoacetic Acid 108-123 keratin Gallus gallus 30-37 10870516-2 2000 The selective adenosine A2A receptor antagonist, 4-[2-[7-amino-2-(2-furyl)(1,2,4)-triazin-5-ylamino]-ethyl]ph enol (ZM241385) (50 nM), increased the release of glutamate (three- to four-fold) and of aspartate (nearly two-fold) upon iodoacetic acid-induced glycolysis inhibition, in the presence or in the absence of Ca2+. Iodoacetic Acid 232-247 adenosine A2a receptor Gallus gallus 14-36 10870516-7 2000 Furthermore, the GABAA receptor antagonist, bicuculline (10 microM), only increased (nearly two-fold) the iodoacetic acid-induced Ca(2+)-dependent release of glutamate, whereas the GABAB receptor antagonist, 3-aminopropyl(diethoxymethyl) phosphinic acid, CGP35348 (100 microM), was devoid of effects on the extracellular accumulation of glutamate and aspartate. Iodoacetic Acid 106-121 gamma-aminobutyric acid type A receptor gamma3 subunit Gallus gallus 17-31 10527932-3 1999 Consistent with earlier reports that GH is sulphydryl-sensitive, we found that recombinant human GH is inhibited by iodoacetic acid, suggesting that at least one cysteine is important for activity [Rhee, Lindau-Shepard, Chave, Galivan and Ryan (1998) Mol. Iodoacetic Acid 116-131 gamma-glutamyl hydrolase Homo sapiens 97-99 10527932-7 1999 Three of the mutant proteins had activities similar to wild-type GH and were inhibited by iodoacetic acid, whereas the C110A mutant had no activity. Iodoacetic Acid 90-105 gamma-glutamyl hydrolase Homo sapiens 65-67 10502668-3 1999 The GlcNAc 2-epimerase activity of recombinant human RnBP was specifically inhibited by SH-reagents such as N-ethylmaleimide, 5, 5"-dithiobis-2-nitrobenzoate, and iodoacetic acid, indicating that the most probable reactive site is a cysteine residue. Iodoacetic Acid 163-178 renin binding protein Homo sapiens 4-22 10502668-3 1999 The GlcNAc 2-epimerase activity of recombinant human RnBP was specifically inhibited by SH-reagents such as N-ethylmaleimide, 5, 5"-dithiobis-2-nitrobenzoate, and iodoacetic acid, indicating that the most probable reactive site is a cysteine residue. Iodoacetic Acid 163-178 renin binding protein Homo sapiens 53-57 10215508-2 1999 Three different approaches were used to inhibit glycolysis: the cells were submitted to iodoacetic acid (IAA), an inhibitor of glyceraldehyde 3-phosphate dehydrogenase, to 2-deoxy-glucose (DG) in glucose-free medium, which was used as a substitute of glucose, or in the absence of glucose. Iodoacetic Acid 105-108 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 127-167 9624118-5 1998 Oxidation by H2O2 prevented modification of the catalytic cysteine of PTP1B by iodoacetic acid, suggesting that it should be possible to monitor the oxidation state of PTP1B in cells by measuring the incorporation of radioactivity into the enzyme after lysis of the cells in the presence of radiolabeled iodoacetic acid. Iodoacetic Acid 79-94 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 70-75 9624118-5 1998 Oxidation by H2O2 prevented modification of the catalytic cysteine of PTP1B by iodoacetic acid, suggesting that it should be possible to monitor the oxidation state of PTP1B in cells by measuring the incorporation of radioactivity into the enzyme after lysis of the cells in the presence of radiolabeled iodoacetic acid. Iodoacetic Acid 79-94 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 168-173 9624118-5 1998 Oxidation by H2O2 prevented modification of the catalytic cysteine of PTP1B by iodoacetic acid, suggesting that it should be possible to monitor the oxidation state of PTP1B in cells by measuring the incorporation of radioactivity into the enzyme after lysis of the cells in the presence of radiolabeled iodoacetic acid. Iodoacetic Acid 304-319 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 70-75 9169015-7 1997 Iodoacetic acid-modified 2CK-XIP inhibits the Na-Ca exchanger but not the PM Ca pump. Iodoacetic Acid 0-15 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 Homo sapiens 29-32 9169015-7 1997 Iodoacetic acid-modified 2CK-XIP inhibits the Na-Ca exchanger but not the PM Ca pump. Iodoacetic Acid 0-15 solute carrier family 8 member A1 Homo sapiens 46-61 9201625-1 1997 This study explored whether annexin V, a protein with established phospholipase A2 inhibiting properties, plays a role in the degradation of membrane phospholipids of adult cardiac myocytes during metabolic inhibition (20 mM 2-deoxyglucose and 1 mM iodoacetic acid). Iodoacetic Acid 249-264 annexin A5 Homo sapiens 28-37 9624118-5 1998 Oxidation by H2O2 prevented modification of the catalytic cysteine of PTP1B by iodoacetic acid, suggesting that it should be possible to monitor the oxidation state of PTP1B in cells by measuring the incorporation of radioactivity into the enzyme after lysis of the cells in the presence of radiolabeled iodoacetic acid. Iodoacetic Acid 304-319 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 168-173 9624118-7 1998 The amount of iodoacetic acid-derived radioactivity associated with PTP1B reached a minimum 10 min after stimulation of cells with EGF and returned to base line values by 40 min, suggesting that the oxidation of PTP1B is reversible in cells. Iodoacetic Acid 14-29 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 68-73 9624118-7 1998 The amount of iodoacetic acid-derived radioactivity associated with PTP1B reached a minimum 10 min after stimulation of cells with EGF and returned to base line values by 40 min, suggesting that the oxidation of PTP1B is reversible in cells. Iodoacetic Acid 14-29 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 212-217 9453549-5 1998 Activation of the HSP promoter was also observed after an addition of iodoacetic acid to hypoxic astrocytes, which reached the maximum when the ADP/ATP ratio reached 50%, but further decline in the energy profile caused inactivation of this promoter. Iodoacetic Acid 70-85 heat shock protein 90 beta family member 2, pseudogene Homo sapiens 18-21 9054543-2 1997 Disruption of the disulfide bonds of mIL-6 by treatment with iodoacetic acid (IAA-IL-6) or iodoacetamide (IAM-IL-6) reduced the biological activity, in the murine hybridoma growth factor assay, by 500- and 200-fold, respectively. Iodoacetic Acid 61-76 interleukin 6 Mus musculus 37-42 9054543-2 1997 Disruption of the disulfide bonds of mIL-6 by treatment with iodoacetic acid (IAA-IL-6) or iodoacetamide (IAM-IL-6) reduced the biological activity, in the murine hybridoma growth factor assay, by 500- and 200-fold, respectively. Iodoacetic Acid 61-76 interleukin 6 Mus musculus 38-42 9054543-2 1997 Disruption of the disulfide bonds of mIL-6 by treatment with iodoacetic acid (IAA-IL-6) or iodoacetamide (IAM-IL-6) reduced the biological activity, in the murine hybridoma growth factor assay, by 500- and 200-fold, respectively. Iodoacetic Acid 61-76 interleukin 6 Mus musculus 82-86 8658553-8 1996 Iodoacetic acid did not significantly alter general metabolism, but considerably modified lysosomal function and AChE activity. Iodoacetic Acid 0-15 acetylcholinesterase Mus musculus 113-117 8603612-7 1996 In agreement with this hypothesis, the effect of CGRP is blocked by 1 microM glybenclamide, a specific inhibitor of ATP-sensitive potassium (K(ATP)) channels, or by pretreatment of cells with 1 mM iodoacetic acid to deplete intracellular ATP. Iodoacetic Acid 197-212 calcitonin-related polypeptide alpha Rattus norvegicus 49-53 8631368-6 1996 When GSH-reduced PSP was carboxymethylated with iodoacetic acid, it still depended on extracellular GSH for its growth effect. Iodoacetic Acid 48-63 regenerating family member 1 alpha Rattus norvegicus 17-20 7681826-6 1993 The formation of 125I-VEGF.alpha 2M complexes was inhibited by iodoacetic acid, indicating that free sulfhydryl groups are required for complex assembly. Iodoacetic Acid 63-78 vascular endothelial growth factor A Homo sapiens 22-26 8530534-1 1995 Actions of monoiodoacetic acid (MIA) as a sulfhydryl reagent on the different stages of the T cell receptor (TCR)-mediated signal transduction were examined. Iodoacetic Acid 11-30 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 92-107 8530534-1 1995 Actions of monoiodoacetic acid (MIA) as a sulfhydryl reagent on the different stages of the T cell receptor (TCR)-mediated signal transduction were examined. Iodoacetic Acid 11-30 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 109-112 8530534-1 1995 Actions of monoiodoacetic acid (MIA) as a sulfhydryl reagent on the different stages of the T cell receptor (TCR)-mediated signal transduction were examined. Iodoacetic Acid 32-35 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 92-107 8530534-1 1995 Actions of monoiodoacetic acid (MIA) as a sulfhydryl reagent on the different stages of the T cell receptor (TCR)-mediated signal transduction were examined. Iodoacetic Acid 32-35 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 109-112 8299220-2 1993 The catalytic properties of the purified enzyme closely resembled those of DNase I purified from the urine of this individual and the following other similarities were observed: molecular masses, iodoacetic acid inactivation kinetics, desialylated isoenzyme patterns. Iodoacetic Acid 196-211 deoxyribonuclease 1 Homo sapiens 75-82 9363259-10 1995 Only hCG kinetics were significantly different between tissue incubated with and without cycloheximide or iodoacetic acid. Iodoacetic Acid 106-121 chorionic gonadotropin subunit beta 5 Homo sapiens 5-8 8720146-8 1995 Monoiodo-acetate and cystamine potently inhibited the enzyme activity, suggesting that cysteine residue(s) are essential for brain TGase. Iodoacetic Acid 0-16 transglutaminase 1 Homo sapiens 131-136 7788886-5 1995 Iodoacetic acid, an inhibitor of GAPDH, eliminated 45Ca transport supported by fructose-1,6-diphosphate, the substrate for aldolase, but transport was completely restored by phosphoenolpyruvate (the substrate for PK), indicating that both of the ATP-producing glycolytic enzymes, GAPDH/PGK and PK, were associated with the SR and functionally capable of providing ATP for the Ca2+ pump. Iodoacetic Acid 0-15 glyceraldehyde-3-phosphate dehydrogenase Oryctolagus cuniculus 33-38 7788886-5 1995 Iodoacetic acid, an inhibitor of GAPDH, eliminated 45Ca transport supported by fructose-1,6-diphosphate, the substrate for aldolase, but transport was completely restored by phosphoenolpyruvate (the substrate for PK), indicating that both of the ATP-producing glycolytic enzymes, GAPDH/PGK and PK, were associated with the SR and functionally capable of providing ATP for the Ca2+ pump. Iodoacetic Acid 0-15 pyruvate kinase PKLR Oryctolagus cuniculus 213-215 7788886-5 1995 Iodoacetic acid, an inhibitor of GAPDH, eliminated 45Ca transport supported by fructose-1,6-diphosphate, the substrate for aldolase, but transport was completely restored by phosphoenolpyruvate (the substrate for PK), indicating that both of the ATP-producing glycolytic enzymes, GAPDH/PGK and PK, were associated with the SR and functionally capable of providing ATP for the Ca2+ pump. Iodoacetic Acid 0-15 glyceraldehyde-3-phosphate dehydrogenase Oryctolagus cuniculus 280-285 7788886-5 1995 Iodoacetic acid, an inhibitor of GAPDH, eliminated 45Ca transport supported by fructose-1,6-diphosphate, the substrate for aldolase, but transport was completely restored by phosphoenolpyruvate (the substrate for PK), indicating that both of the ATP-producing glycolytic enzymes, GAPDH/PGK and PK, were associated with the SR and functionally capable of providing ATP for the Ca2+ pump. Iodoacetic Acid 0-15 pyruvate kinase PKLR Oryctolagus cuniculus 294-296 8076694-3 1994 Chemical modification of cysteine by iodoacetic acid, and histidine by diethylpyrocarbonate, resulted in a near complete inhibition of 65Zn-binding to TP2. Iodoacetic Acid 37-52 transition protein 2 Rattus norvegicus 151-154 8137504-8 1994 Similarly, iodoacetic acid caused a major (90%) loss of ATP and irreversible cell damage as measured by leakage of creatine phosphokinase enzyme and loss of membrane arachidonic acid; ATP loss was followed by fivefold to sevenfold inductions of c-fos, c-jun and jun B transcripts. Iodoacetic Acid 11-26 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 245-250 8137504-8 1994 Similarly, iodoacetic acid caused a major (90%) loss of ATP and irreversible cell damage as measured by leakage of creatine phosphokinase enzyme and loss of membrane arachidonic acid; ATP loss was followed by fivefold to sevenfold inductions of c-fos, c-jun and jun B transcripts. Iodoacetic Acid 11-26 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 252-257 8513795-5 1993 Cross-linking studies with bis(sulfo-succinimidyl)suberate and alkylation with iodoacetic acid under non-reducing and reducing conditions document for the first time that Nef can also form homomeric structures including monomers, dimers, trimers and tetramers in cell lysates and intact cells. Iodoacetic Acid 79-94 S100 calcium binding protein B Homo sapiens 171-174 7681826-6 1993 The formation of 125I-VEGF.alpha 2M complexes was inhibited by iodoacetic acid, indicating that free sulfhydryl groups are required for complex assembly. Iodoacetic Acid 63-78 alpha-2-macroglobulin Homo sapiens 27-35 1862748-3 1991 In addition, we have utilised the loss of the relatively specific labelling of glyceraldehyde-3-phosphate dehydrogenase (G3PDH) by [3H]-iodoacetic acid to show that rabbit articular G3PDH is oxidised in vivo during the animal model of acute arthritis, carrageenin-induced arthritis, in the same way as we have previously shown that cartilage G3PDH is oxidised after in vitro exposure to sublethal doses of H2O2. Iodoacetic Acid 136-151 glyceraldehyde-3-phosphate dehydrogenase Oryctolagus cuniculus 79-119 7510792-1 1993 3 alpha-Hydroxysteroid dehydrogenase (EC 1.1.1.50), purified to homogeneity from rat liver, was strongly inactivated by incubation with a disulfide such as GSSG, L-cystine or L-cystamine, as well as an SH-reagent such as DTNB (5,5"-dithiobis(2-nitrobenzoic acid)), NEM (N-ethylmaleimide) or iodoacetic acid. Iodoacetic Acid 291-306 aldo-keto reductase family 1, member C14 Rattus norvegicus 0-36 1451907-3 1992 Gluconeogenesis from alanine can be prevented by the addition of monoiodo acetic acid (an inhibitor of glyceraldehyde 3-phosphate dehydrogenase), while glucose production from methylglyoxal is only partially inhibited by this compound. Iodoacetic Acid 65-85 glyceraldehyde-3-phosphate dehydrogenase Mus musculus 103-143 1596871-1 1992 Anthralin, iodoacetic acid, BHT, Tween 60 and TPA induced cytoplasmic accumulation of transcripts of the proliferin gene family at or near effective concentrations for promotion of morphological transformation of C3H/10T1/2 cells. Iodoacetic Acid 11-26 prolactin family 2, subfamily c, member 2 Mus musculus 105-115 1856193-10 1991 In contrast, BPTI alkylated with iodoacetic acid inhibited trypsin half as well as the iodoacetamide derivative. Iodoacetic Acid 33-48 spleen trypsin inhibitor I Bos taurus 13-17 1634526-7 1992 Treatment of EDN, liver RNase, and eosinophil cationic protein with iodoacetic acid at pH 5.5 resulted in inactivation of their RNase activity and also destroyed their neurotoxicity. Iodoacetic Acid 68-83 ribonuclease A family member 2 Homo sapiens 13-16 1314493-5 1992 Also, metabolic inhibition by absence of substrate, 10(-4) M KCN, or 5 x 10(-4) M iodoacetic acid inhibited amiloride-insensitive pHi recovery. Iodoacetic Acid 82-97 glucose-6-phosphate isomerase Rattus norvegicus 130-133 1862748-3 1991 In addition, we have utilised the loss of the relatively specific labelling of glyceraldehyde-3-phosphate dehydrogenase (G3PDH) by [3H]-iodoacetic acid to show that rabbit articular G3PDH is oxidised in vivo during the animal model of acute arthritis, carrageenin-induced arthritis, in the same way as we have previously shown that cartilage G3PDH is oxidised after in vitro exposure to sublethal doses of H2O2. Iodoacetic Acid 136-151 glyceraldehyde-3-phosphate dehydrogenase Oryctolagus cuniculus 121-126 1862748-3 1991 In addition, we have utilised the loss of the relatively specific labelling of glyceraldehyde-3-phosphate dehydrogenase (G3PDH) by [3H]-iodoacetic acid to show that rabbit articular G3PDH is oxidised in vivo during the animal model of acute arthritis, carrageenin-induced arthritis, in the same way as we have previously shown that cartilage G3PDH is oxidised after in vitro exposure to sublethal doses of H2O2. Iodoacetic Acid 136-151 glyceraldehyde-3-phosphate dehydrogenase Oryctolagus cuniculus 182-187 1862748-3 1991 In addition, we have utilised the loss of the relatively specific labelling of glyceraldehyde-3-phosphate dehydrogenase (G3PDH) by [3H]-iodoacetic acid to show that rabbit articular G3PDH is oxidised in vivo during the animal model of acute arthritis, carrageenin-induced arthritis, in the same way as we have previously shown that cartilage G3PDH is oxidised after in vitro exposure to sublethal doses of H2O2. Iodoacetic Acid 136-151 glyceraldehyde-3-phosphate dehydrogenase Oryctolagus cuniculus 182-187 34086879-8 2021 IAA exposure decreased expression of the pro-apoptotic factor Bok, the cell cycle regulator Ccnd2, and borderline decreased expression of the anti-apoptotic factor Bcl2l10, the pro-apoptotic factor Aimf1, and the steroidogenic factor Cyp19a1 compared to control. Iodoacetic Acid 0-3 BCL2-related ovarian killer Mus musculus 62-65 2297224-3 1990 Loss of reduced protein thiols, as measured by binding of the thiol reagent iodoacetic acid to GPD, and loss of GPD enzymatic activity occurred in a dose-dependent manner. Iodoacetic Acid 76-91 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 95-98 34453833-7 2021 We exposed adult female mice to IAA in drinking water in vivo and found 0.5 and 10 mg/L IAA concentrations lead to significantly increased mRNA levels of kisspeptin (Kiss1) in the arcuate nucleus, while not affecting Kiss1 in the anteroventral periventricular nucleus. Iodoacetic Acid 32-35 KiSS-1 metastasis-suppressor Mus musculus 154-164 34453833-7 2021 We exposed adult female mice to IAA in drinking water in vivo and found 0.5 and 10 mg/L IAA concentrations lead to significantly increased mRNA levels of kisspeptin (Kiss1) in the arcuate nucleus, while not affecting Kiss1 in the anteroventral periventricular nucleus. Iodoacetic Acid 32-35 KiSS-1 metastasis-suppressor Mus musculus 166-171 34453833-7 2021 We exposed adult female mice to IAA in drinking water in vivo and found 0.5 and 10 mg/L IAA concentrations lead to significantly increased mRNA levels of kisspeptin (Kiss1) in the arcuate nucleus, while not affecting Kiss1 in the anteroventral periventricular nucleus. Iodoacetic Acid 88-91 KiSS-1 metastasis-suppressor Mus musculus 154-164 34453833-7 2021 We exposed adult female mice to IAA in drinking water in vivo and found 0.5 and 10 mg/L IAA concentrations lead to significantly increased mRNA levels of kisspeptin (Kiss1) in the arcuate nucleus, while not affecting Kiss1 in the anteroventral periventricular nucleus. Iodoacetic Acid 88-91 KiSS-1 metastasis-suppressor Mus musculus 166-171 34453833-8 2021 Both 10 mg/L IAA exposure in vivo and 20 muM IAA in vitro reduced follicle stimulating hormone (FSHbeta)-positive cell number and Fshb mRNA expression. Iodoacetic Acid 13-16 glycoprotein hormones, alpha subunit Mus musculus 96-103 34453833-8 2021 Both 10 mg/L IAA exposure in vivo and 20 muM IAA in vitro reduced follicle stimulating hormone (FSHbeta)-positive cell number and Fshb mRNA expression. Iodoacetic Acid 13-16 follicle stimulating hormone beta Mus musculus 130-134 34453833-8 2021 Both 10 mg/L IAA exposure in vivo and 20 muM IAA in vitro reduced follicle stimulating hormone (FSHbeta)-positive cell number and Fshb mRNA expression. Iodoacetic Acid 45-48 glycoprotein hormones, alpha subunit Mus musculus 96-103 34453833-8 2021 Both 10 mg/L IAA exposure in vivo and 20 muM IAA in vitro reduced follicle stimulating hormone (FSHbeta)-positive cell number and Fshb mRNA expression. Iodoacetic Acid 45-48 follicle stimulating hormone beta Mus musculus 130-134 34453833-9 2021 IAA did not alter luteinizing hormone (LHbeta) expression in vivo, though exposure to 20 muM IAA decreased expression of Lhb and glycoprotein hormones, alpha subunit (Cga) mRNA in vitro. Iodoacetic Acid 0-3 chromogranin A Mus musculus 167-170 34453833-10 2021 IAA also had toxic effects in the pituitary, inducing DNA damage and P21/Cdkn1a expression in vitro (20 muM IAA) and DNA damage and Cdkn1a expression in vivo (500 mg/L). Iodoacetic Acid 0-3 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 73-79 34453833-10 2021 IAA also had toxic effects in the pituitary, inducing DNA damage and P21/Cdkn1a expression in vitro (20 muM IAA) and DNA damage and Cdkn1a expression in vivo (500 mg/L). Iodoacetic Acid 0-3 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 132-138 34086879-8 2021 IAA exposure decreased expression of the pro-apoptotic factor Bok, the cell cycle regulator Ccnd2, and borderline decreased expression of the anti-apoptotic factor Bcl2l10, the pro-apoptotic factor Aimf1, and the steroidogenic factor Cyp19a1 compared to control. Iodoacetic Acid 0-3 cyclin D2 Mus musculus 92-97 34086879-8 2021 IAA exposure decreased expression of the pro-apoptotic factor Bok, the cell cycle regulator Ccnd2, and borderline decreased expression of the anti-apoptotic factor Bcl2l10, the pro-apoptotic factor Aimf1, and the steroidogenic factor Cyp19a1 compared to control. Iodoacetic Acid 0-3 Bcl2-like 10 Mus musculus 164-171 34086879-8 2021 IAA exposure decreased expression of the pro-apoptotic factor Bok, the cell cycle regulator Ccnd2, and borderline decreased expression of the anti-apoptotic factor Bcl2l10, the pro-apoptotic factor Aimf1, and the steroidogenic factor Cyp19a1 compared to control. Iodoacetic Acid 0-3 cytochrome P450, family 19, subfamily a, polypeptide 1 Mus musculus 234-241 34086879-9 2021 IAA exposure increased expression of the pro-apoptotic factors Bax and Aimf1, the anti-apoptotic factor Bcl2l10, the cell cycle regulators Ccna2, Ccnb1, Ccne1, and Cdk4, and estrogen receptor Esr1 compared to control. Iodoacetic Acid 0-3 BCL2-associated X protein Mus musculus 63-66 34086879-9 2021 IAA exposure increased expression of the pro-apoptotic factors Bax and Aimf1, the anti-apoptotic factor Bcl2l10, the cell cycle regulators Ccna2, Ccnb1, Ccne1, and Cdk4, and estrogen receptor Esr1 compared to control. Iodoacetic Acid 0-3 Bcl2-like 10 Mus musculus 104-111 34086879-9 2021 IAA exposure increased expression of the pro-apoptotic factors Bax and Aimf1, the anti-apoptotic factor Bcl2l10, the cell cycle regulators Ccna2, Ccnb1, Ccne1, and Cdk4, and estrogen receptor Esr1 compared to control. Iodoacetic Acid 0-3 cyclin A2 Mus musculus 139-144 34086879-9 2021 IAA exposure increased expression of the pro-apoptotic factors Bax and Aimf1, the anti-apoptotic factor Bcl2l10, the cell cycle regulators Ccna2, Ccnb1, Ccne1, and Cdk4, and estrogen receptor Esr1 compared to control. Iodoacetic Acid 0-3 cyclin B1 Mus musculus 146-151 34086879-9 2021 IAA exposure increased expression of the pro-apoptotic factors Bax and Aimf1, the anti-apoptotic factor Bcl2l10, the cell cycle regulators Ccna2, Ccnb1, Ccne1, and Cdk4, and estrogen receptor Esr1 compared to control. Iodoacetic Acid 0-3 cyclin E1 Mus musculus 153-158 34086879-9 2021 IAA exposure increased expression of the pro-apoptotic factors Bax and Aimf1, the anti-apoptotic factor Bcl2l10, the cell cycle regulators Ccna2, Ccnb1, Ccne1, and Cdk4, and estrogen receptor Esr1 compared to control. Iodoacetic Acid 0-3 cyclin-dependent kinase 4 Mus musculus 164-168 34086879-9 2021 IAA exposure increased expression of the pro-apoptotic factors Bax and Aimf1, the anti-apoptotic factor Bcl2l10, the cell cycle regulators Ccna2, Ccnb1, Ccne1, and Cdk4, and estrogen receptor Esr1 compared to control. Iodoacetic Acid 0-3 estrogen receptor 1 (alpha) Mus musculus 192-196 34086879-10 2021 IAA exposure decreased expression of Cat and Sod1, and increased expression of Cat, Gpx, and Nrf2. Iodoacetic Acid 0-3 catalase Mus musculus 37-40 34086879-10 2021 IAA exposure decreased expression of Cat and Sod1, and increased expression of Cat, Gpx, and Nrf2. Iodoacetic Acid 0-3 superoxide dismutase 1, soluble Mus musculus 45-49 34086879-10 2021 IAA exposure decreased expression of Cat and Sod1, and increased expression of Cat, Gpx, and Nrf2. Iodoacetic Acid 0-3 catalase Mus musculus 79-82 34086879-10 2021 IAA exposure decreased expression of Cat and Sod1, and increased expression of Cat, Gpx, and Nrf2. Iodoacetic Acid 0-3 peroxiredoxin 6 pseudogene 2 Mus musculus 84-87 34086879-10 2021 IAA exposure decreased expression of Cat and Sod1, and increased expression of Cat, Gpx, and Nrf2. Iodoacetic Acid 0-3 nuclear factor, erythroid derived 2, like 2 Mus musculus 93-97 34299412-11 2021 Phosphorylated Akt reduced IAA-induced oxidative stress and increased cell survival. Iodoacetic Acid 27-30 thymoma viral proto-oncogene 1 Mus musculus 15-18 34396019-3 2021 Methods: We developed TRPV4-knockout (TRPV4-KO) rats and assessed the effects of Trpv4 gene deficiency in a monoiodoacetate (MIA)-induced OA pain model (MIA rats) by examining pain-related behavior, pathological changes, and electrophysiological changes in dorsal root ganglion (DRG) neurons. Iodoacetic Acid 108-123 transient receptor potential cation channel, subfamily V, member 4 Rattus norvegicus 81-86 34299412-12 2021 Our results indicate that gintonin attenuated IAA-induced oxidative stress in neuronal cells by activating the LPA1 receptor-BDNF-TrkB-Akt signaling pathway. Iodoacetic Acid 46-49 lysophosphatidic acid receptor 1 Mus musculus 111-115 34299412-12 2021 Our results indicate that gintonin attenuated IAA-induced oxidative stress in neuronal cells by activating the LPA1 receptor-BDNF-TrkB-Akt signaling pathway. Iodoacetic Acid 46-49 brain derived neurotrophic factor Mus musculus 125-129 34299412-12 2021 Our results indicate that gintonin attenuated IAA-induced oxidative stress in neuronal cells by activating the LPA1 receptor-BDNF-TrkB-Akt signaling pathway. Iodoacetic Acid 46-49 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 130-134 34299412-12 2021 Our results indicate that gintonin attenuated IAA-induced oxidative stress in neuronal cells by activating the LPA1 receptor-BDNF-TrkB-Akt signaling pathway. Iodoacetic Acid 46-49 thymoma viral proto-oncogene 1 Mus musculus 135-138 2797589-4 1989 In both cases oligonucleotide probing of amplified DNA and isoelectric focusing (IEF) of apo VLDL identified the correct apolipoprotein E phenotype as defined by peptide mapping and IEF of purified apolipoprotein E after modification with iodoacetic acid. Iodoacetic Acid 239-254 apolipoprotein E Homo sapiens 121-137 3219362-8 1988 Modification of PRI with iodoacetic acid, p-(hydroxymercuri)benzoate, and 5,5"-dithiobis(2-nitrobenzoic acid) reveals that at least 30 of the 32 cysteine residues of PRI are in the reduced form. Iodoacetic Acid 25-40 ribonuclease/angiogenin inhibitor 1 Homo sapiens 16-19 2468667-5 1989 Complex formation is complete after 4 h and is inhibited by pretreating alpha 2M with dithiothreitol, iodoacetamide, iodoacetic acid, and N-ethylmaleimide. Iodoacetic Acid 117-132 pregnancy zone protein Bos taurus 72-80 3365394-2 1988 The reduced and carboxymethylated apolipoprotein B was incubated with 50 mM [14C]methylamine at pH 8.5 at 30 degrees C. Covalent incorporation of [14C]methylamine was observed with concomitant generation of new sulfhydryl groups, which could be blocked with [3H]- or [14C]iodoacetic acid. Iodoacetic Acid 272-287 apolipoprotein B Homo sapiens 34-50 3169268-2 1988 By totally inhibiting (greater than 95%) glyceraldehyde-3-phosphate dehydrogenase with low concentrations of iodoacetic acid (0.2 mM) in the perfusion medium, active glycolysis results in the accumulation of sugar phosphate species (fructose 1,6-bisphosphate, dihydroxyacetone phosphate, and glyceraldehyde 3-phosphate) which can be observed in the 31P-NMR spectrum. Iodoacetic Acid 109-124 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 41-81 2485328-1 1988 The refolding of iodoacetic acid-blocked human serum albumin (HSA) was studied using a modified competitive inhibition ELISA. Iodoacetic Acid 17-32 albumin Homo sapiens 47-60 2457025-9 1988 Cytochrome c reduction was not inhibited by several mitochondrial respiratory chain inhibitors (azide, cyanide, and rotenone) but was sensitive to thiol-reactive agents (p-chloromercuribenzoate and monoiodo acetate). Iodoacetic Acid 198-214 cytochrome c, somatic Homo sapiens 0-12 3791352-3 1986 Myoglobin was inactivated by adding 2 X 10(-3) mol X litre-1 sodium nitrite to the bath to abolish the facilitated diffusion of oxygen in the presence or absence of glycolytic blockade by 10(-4) mol X litre-1 sodium iodoacetate. Iodoacetic Acid 209-227 myoglobin Homo sapiens 0-9 3391424-5 1988 The mean production of HCG, HPL, SP1, and PAPP-A was decreased when either cycloheximide, puromycin, iodoacetic acid, or 2,4-dinitrophenol had been added to the perfusing medium. Iodoacetic Acid 101-116 pappalysin 1 Homo sapiens 42-48 3442674-6 1987 Apo and holo crystalline s-MDH are also inhibited by iodoacetic acid. Iodoacetic Acid 53-68 aminopeptidase O (putative) Homo sapiens 0-3 3427116-7 1987 In further experiments, pig serum was incubated for various periods of time in the presence and absence of the LCAT inhibitor sodium iodoacetate. Iodoacetic Acid 126-144 lecithin-cholesterol acyltransferase Sus scrofa 111-115 2822124-11 1987 As with CANP1 and CANP2, leupeptin and sulfhydryl-modifying compounds, NEM and iodoacetic acid, inhibited the activity of CANP3. Iodoacetic Acid 79-94 calpain 1 Bos taurus 8-13 2822124-11 1987 As with CANP1 and CANP2, leupeptin and sulfhydryl-modifying compounds, NEM and iodoacetic acid, inhibited the activity of CANP3. Iodoacetic Acid 79-94 calpain 2 Bos taurus 18-23 2822124-11 1987 As with CANP1 and CANP2, leupeptin and sulfhydryl-modifying compounds, NEM and iodoacetic acid, inhibited the activity of CANP3. Iodoacetic Acid 79-94 calpain 3 Bos taurus 122-127 3657387-1 1987 The membrane-bound acetylcholinesterase (AchE) from human peripheral blood lymphocyte gives only one symmetrical peak on sucrose density gradient centrifugation in the presence of Triton X-100 detergent, with the calculated sedimentation coefficient of 6.5 S. However, this dimeric form of AchE was converted to a monomeric 3.8 S form when treated with 2-mercaptoethanol and iodoacetic acid. Iodoacetic Acid 375-390 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 3675552-1 1987 Carboxymethylation using 14C- or 3H-labelled iodoacetic acid has been used to identify the cysteine residues in bovine rhodopsin involved in the formation of the two intramolecular disulphide bridges. Iodoacetic Acid 45-60 rhodopsin Bos taurus 119-128 2947567-8 1986 In contrast, inhibitions of N-acetyl-beta-glucosaminidase activities of the two isoenzymes by iodoacetic acid, iodoacetamide and ethylmaleimide were not comparable; Hex B was more susceptible to inhibition by these agents at 20 mM concentration. Iodoacetic Acid 94-109 O-GlcNAcase Homo sapiens 28-57 3002349-3 1985 In the present study, purified spinach chloroplast fructose-1,6-bisphosphatase was reduced, S-carboxymethylated with iodoacetic acid, and cleaved with either cyanogen bromide or trypsin. Iodoacetic Acid 117-132 fructose-bisphosphatase 1 Sus scrofa 51-78 6466662-1 1984 Human erythrocyte membrane-bound acetylcholinesterase was converted to a monomeric species by treatment of ghosts with 2-mercaptoethanol and iodoacetic acid. Iodoacetic Acid 141-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 4087567-8 1985 Cathepsin B was more sensitive than cathepsin H to inhibition by antipain, chymostatin, iodoacetic acid and mercuric chloride as well as leupeptin and E-64. Iodoacetic Acid 88-103 cathepsin B Rattus norvegicus 0-11 4087567-8 1985 Cathepsin B was more sensitive than cathepsin H to inhibition by antipain, chymostatin, iodoacetic acid and mercuric chloride as well as leupeptin and E-64. Iodoacetic Acid 88-103 cathepsin H Rattus norvegicus 36-47 4087567-9 1985 Despite the similarity in inhibitory effects of iodoacetic acid and E-64, the rat spleen cathepsin H was characterized by insensitivity to mercuric chloride that had a considerable inhibitory effect on the corresponding enzyme from rat liver and the rat spleen cathepsin B. Iodoacetic Acid 48-63 cathepsin H Rattus norvegicus 89-100 6511787-4 1984 The propensity of lysophospholipase to aggregate was not due to extensive intermolecular disulfide bonding because it contained a single cysteine residue as assessed by amino acid analyses and incorporated 0.986 mol of p-chloromercuribenzoic acid/mol of native enzyme or 0.958 mol of iodoacetic acid/mol of reduced and denatured enzyme. Iodoacetic Acid 284-299 phospholipase B1 Homo sapiens 18-35 2990536-6 1985 Serum albumin was reduced or reduced and alkylated with iodoacetic acid or iodoacetamide. Iodoacetic Acid 56-71 albumin Homo sapiens 0-13 2984068-1 1985 The disulfide bonds of two lactogenic hormones, ovine prolactin (oPRL) and human growth hormone (hGH), were reduced with dithiothreitol under denaturing conditions and alkylated with iodoacetic acid. Iodoacetic Acid 183-198 prolactin Homo sapiens 54-63 2984068-1 1985 The disulfide bonds of two lactogenic hormones, ovine prolactin (oPRL) and human growth hormone (hGH), were reduced with dithiothreitol under denaturing conditions and alkylated with iodoacetic acid. Iodoacetic Acid 183-198 growth hormone 1 Homo sapiens 81-95 952954-3 1976 Three methionine-modified derivatives of ovine prolactin have been prepared: two by oxidation of the methionines by H2O2 to sulfoxide (partial and complete), and the third by complete alkylation of the metionines with iodoacetic acid to the carboxymethyl sulfonium salts. Iodoacetic Acid 218-233 prolactin Homo sapiens 47-56 6324816-7 1984 AGEPC-induced O-2 production was suppressed by the glycolytic inhibitor 2-deoxy-D-glucose (2-DG) and the sulfhydryl reagents N-ethylmaleimide (NEM) and iodoacetic acid (1A). Iodoacetic Acid 152-167 immunoglobulin kappa variable 1D-39 Homo sapiens 14-17 6885310-8 1983 The elevation of cyclic AMP and cyclic GMP levels prior to pathological morphology suggests that the iodoacetic acid-induced disruption of cyclic nucleotide metabolism may be associated with the degeneration of the cone photoreceptors. Iodoacetic Acid 101-116 5'-nucleotidase, cytosolic II Homo sapiens 39-42 6873252-3 1983 The decrease of ATP concentration is independent of both the degree of mechanical disintegration of the tissue (mash, homogenate) and of the presence of inhibitors of ATP biosynthesis (2,4-dinitrophenol, monoiodoacetate). Iodoacetic Acid 204-219 ATPase phospholipid transporting 8A2 Homo sapiens 16-19 6309757-0 1983 Reaction of calcium-activated neutral protease (CANP) with an epoxysuccinyl derivative (E64c) and iodoacetic acid. Iodoacetic Acid 98-113 calpain 1 Homo sapiens 48-52 6309757-1 1983 The reaction of calcium activated neutral protease (CANP) with an epoxysuccinyl derivative (E64c) and iodoacetic acid (IAA) was examined in the presence of Ca2+, which specifically accelerates the rate of inactivation by these inhibitors. Iodoacetic Acid 102-117 calpain 1 Homo sapiens 16-50 6309757-1 1983 The reaction of calcium activated neutral protease (CANP) with an epoxysuccinyl derivative (E64c) and iodoacetic acid (IAA) was examined in the presence of Ca2+, which specifically accelerates the rate of inactivation by these inhibitors. Iodoacetic Acid 102-117 calpain 1 Homo sapiens 52-56 6309757-1 1983 The reaction of calcium activated neutral protease (CANP) with an epoxysuccinyl derivative (E64c) and iodoacetic acid (IAA) was examined in the presence of Ca2+, which specifically accelerates the rate of inactivation by these inhibitors. Iodoacetic Acid 119-122 calpain 1 Homo sapiens 16-50 6309757-1 1983 The reaction of calcium activated neutral protease (CANP) with an epoxysuccinyl derivative (E64c) and iodoacetic acid (IAA) was examined in the presence of Ca2+, which specifically accelerates the rate of inactivation by these inhibitors. Iodoacetic Acid 119-122 calpain 1 Homo sapiens 52-56 6830786-1 1983 Purified detergent solubilized dimeric human erythrocyte acetylcholinesterase (6.3 S form) was converted to a stable monomeric 3.9 S species when treated with 2-mercaptoethanol and iodoacetic acid. Iodoacetic Acid 181-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 6301876-1 1983 The active site of calcium-activated neutral protease (CANP) was specifically labeled with iodoacetic acid. Iodoacetic Acid 91-106 calpain 1 Homo sapiens 55-59 7150571-2 1982 After initiation of disulfide bond formation associated with the folding process of reduced human lysozyme, molecules have been trapped in a stable form with iodoacetic acid (preserving disulfide bonds) at various times of reoxidation. Iodoacetic Acid 158-173 lysozyme Homo sapiens 98-106 6952939-0 1982 The specificity of active-site alkylation by iodoacetic acid in the enzyme thiosulfate sulfurtransferase. Iodoacetic Acid 45-60 thiosulfate sulfurtransferase Homo sapiens 75-104 6952939-1 1982 The active-site sulfhydryl group in the enzyme thiosulfate sulfurtransferase (rhodanese; thiosulfate:cyanide sulfurtransferase; EC 2.8.1.1) is alkylated rapidly by iodoacetic acid in the free enzyme form, E, with complete loss of sulfurtransferase activity. Iodoacetic Acid 164-179 thiosulfate sulfurtransferase Homo sapiens 47-76 30487-1 1978 Cow kappa-casein has been modified by photo-oxidation in the presence of rose bengal and by the chemical reagents diethyl pyrocarbonate, 2-hydroxy-5-nitro-benzyl bromide and iodoacetic acid. Iodoacetic Acid 174-189 casein kappa Bos taurus 4-16 30487-4 1978 Treatment of kappa-casein with 2-hydroxy-5-nitrobenzyl bromide and iodoacetic acid caused the loss of tryptophan and methionine residues respectively but, in both cases, the susceptibility of the modified protein to chymosin hydrolysis remained unaffected. Iodoacetic Acid 67-82 casein kappa Bos taurus 13-25 30487-4 1978 Treatment of kappa-casein with 2-hydroxy-5-nitrobenzyl bromide and iodoacetic acid caused the loss of tryptophan and methionine residues respectively but, in both cases, the susceptibility of the modified protein to chymosin hydrolysis remained unaffected. Iodoacetic Acid 67-82 chymosin Bos taurus 216-224 684867-5 1978 It is shown that the cathepsin B1 activity in the brain grey matter grows in the presence of L-cysteine and is inhibited under the effect of pChMB, monoiodoacetic acid, Mn2+ and Cu2+. Iodoacetic Acid 148-167 cathepsin B Homo sapiens 21-33 23766-12 1977 Degradation by cathepsin B was inhibited by lack of reducing agent, or by myoglobin, iodoacetic acid and leupeptin, but not by pepstatin. Iodoacetic Acid 85-100 cathepsin B Rattus norvegicus 15-26 10991-1 1976 The unique methionine-15 residue located at the N-terminal site of iso- or beta-phospholipase A2 from porcine pancrease has been specifically carboxymethylated with iodoacetic acid. Iodoacetic Acid 165-180 phospholipase A2 group IB Homo sapiens 80-96 948989-4 1976 The MP2 are alterated by perfusion of glucose or iodoacetic acid. Iodoacetic Acid 49-64 tryptase pseudogene 1 Homo sapiens 4-7 6872358-7 1983 Granule enzyme extrusion from C18-AGEPC-treated neutrophils was inhibited by the sulfhydryl reagents, N-ethylmaleimide and iodoacetic acid, and by the glycolytic inhibitor, 2-deoxy-D-glucose. Iodoacetic Acid 123-138 Bardet-Biedl syndrome 9 Homo sapiens 30-33 6309757-6 1983 CANP modified with E64c or IAA lost one of the 3 SH groups (class II SH groups) which were exposed at the surface by addition of Ca2+. Iodoacetic Acid 27-30 calpain 1 Homo sapiens 0-4 7287657-10 1981 Mixture of vero-ER and component B labeled with [14C]iodoacetic acid formed "6S" ER with 14C-activities under hypotonic conditions. Iodoacetic Acid 53-68 estrogen receptor 1 Bos taurus 16-18 365839-6 1978 Pretreatment of AM with iodoacetic acid, trypsin, neuraminidase, or colchicine diminished attachment of L at 2 h. Neuraminidase pretreatment of L resulted in increased binding to nontreated AM. Iodoacetic Acid 24-39 neuraminidase 1 Homo sapiens 114-127 163256-5 1975 Incubation of the glyceraldehyde 3-phosphate dehydrogenase with glyceraldehyde 3-phosphate, acetyl phosphate, iodoacetic acid, or iodosobenzoate inhibits the formation of the acid-stable complex with 3-pyridinealdehyde-NAD. Iodoacetic Acid 110-125 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 18-58 1133791-27 1975 3 mM sodium cyanide plus 3 mM sodium iodoacetate caused a variable release of renin associated with depletion of content within 4 hr. Iodoacetic Acid 30-48 renin Rattus norvegicus 78-83 810943-1 1975 The poisoning of pregnant guinea pigs with monoiodineacetate, an inhibitor of carbohydrate metabolism in the glyceraldehyde-3-phosphate dehydrogenase phase, leads within a few minutes to the formation of syncytial plasma protrusions in the maternal blood lacunae of the placenta. Iodoacetic Acid 43-60 glyceraldehyde-3-phosphate dehydrogenase Cavia porcellus 109-149 5073433-0 1972 [The effect of mono-iodoacetic acid on the electrophysiologic properties of the giant neurons of the grape snail]. Iodoacetic Acid 15-35 snail family transcriptional repressor 1 Homo sapiens 107-112 4198623-9 1973 Pretreatment of alpha(2)-macroglobulin with cathepsin B1 inactivated by exposure to pH8.5 or iodoacetic acid, in large molar excess, did not prevent the subsequent binding of active enzyme. Iodoacetic Acid 93-108 alpha-2-macroglobulin Homo sapiens 16-38 4198623-9 1973 Pretreatment of alpha(2)-macroglobulin with cathepsin B1 inactivated by exposure to pH8.5 or iodoacetic acid, in large molar excess, did not prevent the subsequent binding of active enzyme. Iodoacetic Acid 93-108 cathepsin B Homo sapiens 44-56 14955620-2 1952 The synthesis of rhodopsin, though unaffected by the less powerful sulfhydryl reagents, monoiodoacetic acid and its amide, is inhibited completely by p-chloromercuribenzoate (PCMB). Iodoacetic Acid 88-107 rhodopsin Bos taurus 17-26 4398402-0 1971 Inhibition of glyceraldehyde-3-phosphate dehydrogenase in mammalian nerve by iodoacetic acid. Iodoacetic Acid 77-92 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 14-54 13958738-0 1963 [Activity of glyceraldehyde-3-phosphate dehydrogenase in the rabbit retina and in experimental pigmentary retinitis induced by monoiodoacetate. Iodoacetic Acid 127-142 glyceraldehyde-3-phosphate dehydrogenase Oryctolagus cuniculus 13-53 32382851-6 2021 Interestingly, shRNA of P2X4R could protect against IAA-induced activation of p38, and SB203580, a specific inhibitor of p38, could reverse IAA-induced neurotoxicity, indicating that p38 is a downstream signaling molecule of P2X4R. Iodoacetic Acid 52-55 mitogen-activated protein kinase 14 Mus musculus 78-81 32382851-6 2021 Interestingly, shRNA of P2X4R could protect against IAA-induced activation of p38, and SB203580, a specific inhibitor of p38, could reverse IAA-induced neurotoxicity, indicating that p38 is a downstream signaling molecule of P2X4R. Iodoacetic Acid 140-143 mitogen-activated protein kinase 14 Mus musculus 121-124 32382851-6 2021 Interestingly, shRNA of P2X4R could protect against IAA-induced activation of p38, and SB203580, a specific inhibitor of p38, could reverse IAA-induced neurotoxicity, indicating that p38 is a downstream signaling molecule of P2X4R. Iodoacetic Acid 140-143 mitogen-activated protein kinase 14 Mus musculus 121-124 33060735-0 2020 TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate-induced arthritis rat model. Iodoacetic Acid 99-114 transporter 2, ATP binding cassette subfamily B member Rattus norvegicus 0-4 33841009-0 2021 Ginsenoside Rb1 inhibits monoiodoacetate-induced osteoarthritis in postmenopausal rats through prevention of cartilage degradation. Iodoacetic Acid 25-40 RB transcriptional corepressor 1 Rattus norvegicus 12-15 33841009-4 2021 In the present study, we investigated whether Rb1 had an antiinflammatory effect on monoiodoacetate (MIA)-induced OA in ovariectomized rats as a model of postmenopausal arthritis. Iodoacetic Acid 84-99 RB transcriptional corepressor 1 Rattus norvegicus 46-49 33126034-8 2021 Simultaneously, DNA damage was also elevated in the nuclei of these IAA-exposed mouse oocytes, evidenced by increased gamma-H2AX focus number. Iodoacetic Acid 68-71 H2A.X variant histone Mus musculus 118-128 33060735-0 2020 TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate-induced arthritis rat model. Iodoacetic Acid 99-114 toll-like receptor 4 Rattus norvegicus 30-50 33060735-2 2020 Thus, we investigated whether TAP2, a peptide antagonist of TLR4, reduces the monoiodoacetate (MIA)-induced arthritic pain and cartilage degradation in rats. Iodoacetic Acid 78-93 transporter 2, ATP binding cassette subfamily B member Rattus norvegicus 30-34 32696209-0 2020 TissueGene-C promotes an anti-inflammatory micro-environment in a rat monoiodoacetate model of osteoarthritis via polarization of M2 macrophages leading to pain relief and structural improvement. Iodoacetic Acid 70-85 transglutaminase 2 Homo sapiens 0-12 32622201-0 2020 Casticin suppresses monoiodoacetic acid-induced knee osteoarthritis through inhibiting HIF-1alpha/NLRP3 inflammasome signaling. Iodoacetic Acid 20-39 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 87-97 33050855-8 2020 The proteolytic activity of FSCP was completely abolished by iodoacetic acid (IAA), suggesting FSCP is a cysteine protease. Iodoacetic Acid 61-76 cathepsin B Homo sapiens 105-122 33050855-8 2020 The proteolytic activity of FSCP was completely abolished by iodoacetic acid (IAA), suggesting FSCP is a cysteine protease. Iodoacetic Acid 78-81 cathepsin B Homo sapiens 105-122 31438731-0 2020 Use of magnetic capture to identify elevated levels of CCL2 following intra-articular injection of monoiodoacetate in rats. Iodoacetic Acid 99-114 C-C motif chemokine ligand 2 Rattus norvegicus 55-59 31438731-3 2020 Here, the feasibility of magnetic capture for detecting monocyte chemoattractant protein-1 (MCP-1 or CCL2) is demonstrated after intra-articular injection of monoiodoacetate (MIA) in the rat knee. Iodoacetic Acid 158-173 C-C motif chemokine ligand 2 Rattus norvegicus 56-90 31438731-3 2020 Here, the feasibility of magnetic capture for detecting monocyte chemoattractant protein-1 (MCP-1 or CCL2) is demonstrated after intra-articular injection of monoiodoacetate (MIA) in the rat knee. Iodoacetic Acid 158-173 C-C motif chemokine ligand 2 Rattus norvegicus 92-97 31438731-3 2020 Here, the feasibility of magnetic capture for detecting monocyte chemoattractant protein-1 (MCP-1 or CCL2) is demonstrated after intra-articular injection of monoiodoacetate (MIA) in the rat knee. Iodoacetic Acid 158-173 C-C motif chemokine ligand 2 Rattus norvegicus 101-105 32622201-0 2020 Casticin suppresses monoiodoacetic acid-induced knee osteoarthritis through inhibiting HIF-1alpha/NLRP3 inflammasome signaling. Iodoacetic Acid 20-39 NLR family, pyrin domain containing 3 Rattus norvegicus 98-103 31356950-6 2019 Iodoacetamide or iodoacetic acid treatment of proinsulin inclusion bodies, in suspension under non-reducing conditions and without any chaotropic agents, showed six alkylations, suggesting that these cytoplasmic aggregates were assembled from reduced monomers, with their -SH groups pointing towards hydrophilic surface. Iodoacetic Acid 17-32 insulin Homo sapiens 46-56 32801641-5 2020 The purpose of our research was to explore the anti-inflammatory effects of Chrysin on KOA, which was induced by monoiodoacetic acid (MIA) in rats by targeting the NLRP3 inflammasome in the hopes of identifying an effective drug to treat KOA. Iodoacetic Acid 113-132 NLR family, pyrin domain containing 3 Rattus norvegicus 164-169 32801641-5 2020 The purpose of our research was to explore the anti-inflammatory effects of Chrysin on KOA, which was induced by monoiodoacetic acid (MIA) in rats by targeting the NLRP3 inflammasome in the hopes of identifying an effective drug to treat KOA. Iodoacetic Acid 134-137 NLR family, pyrin domain containing 3 Rattus norvegicus 164-169 31693920-4 2020 IAA exposure significantly decreased follicle growth, expression of cell cycle stimulators, and the proliferation marker Ki67. Iodoacetic Acid 0-3 antigen identified by monoclonal antibody Ki 67 Mus musculus 121-125 31693920-5 2020 In contrast, IAA increased expression of the cell cycle inhibitor Cdkn1a. Iodoacetic Acid 13-16 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 66-72 30938133-2 2019 The aim of this study, was to describe the effect of a multistrain probiotic (PB) and chondroitin sulfate (CS), administered separately or in combination, on the expression of Ptgs2, Tgfb1 and Col2a1 during monoiodoacetate-induced OA in male rats. Iodoacetic Acid 207-222 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 176-181 30938133-2 2019 The aim of this study, was to describe the effect of a multistrain probiotic (PB) and chondroitin sulfate (CS), administered separately or in combination, on the expression of Ptgs2, Tgfb1 and Col2a1 during monoiodoacetate-induced OA in male rats. Iodoacetic Acid 207-222 transforming growth factor, beta 1 Rattus norvegicus 183-188 30938133-2 2019 The aim of this study, was to describe the effect of a multistrain probiotic (PB) and chondroitin sulfate (CS), administered separately or in combination, on the expression of Ptgs2, Tgfb1 and Col2a1 during monoiodoacetate-induced OA in male rats. Iodoacetic Acid 207-222 collagen type II alpha 1 chain Rattus norvegicus 193-199 31089001-0 2019 Chondroprotective effects of platelet lysate towards monoiodoacetate-induced arthritis by suppression of TNF-alpha-induced activation of NF-kB pathway in chondrocytes. Iodoacetic Acid 53-68 tumor necrosis factor Homo sapiens 105-114 30963238-10 2019 In vitro, trehalose and other soluble carbohydrates promoted NR activity, which was blocked by the tricarboxylic acid cycle inhibitor iodoacetic acid. Iodoacetic Acid 134-149 nitrate reductase 1 Arabidopsis thaliana 61-63 31308795-7 2019 Finally, the analgesic effect of TAP2 was reproduced in rats with monoiodoacetate-induced osteoarthritic pain. Iodoacetic Acid 66-81 transporter 2, ATP binding cassette subfamily B member Rattus norvegicus 33-37 31140423-0 2019 [Expression of KCNA2 in the dorsal root ganglia of rats with osteoarthritis pain induced by monoiodoacetate]. Iodoacetic Acid 92-107 potassium voltage-gated channel subfamily A member 2 Rattus norvegicus 15-20 31140423-1 2019 OBJECTIVE: To investigate the changes in the expression of voltage-gated potassium channel subunit KCNA2 in the dorsal root ganglion (DRG) neurons of rats with osteoarthritis (OA) pain induced by sodium monoiodoacetate and explore the mechanism. Iodoacetic Acid 196-218 potassium voltage-gated channel subfamily A member 2 Rattus norvegicus 99-104 30048934-0 2018 Drinking water disinfection byproduct iodoacetic acid interacts with catalase and induces cytotoxicity in mouse primary hepatocytes. Iodoacetic Acid 38-53 catalase Mus musculus 69-77 30048934-4 2018 This study investigated the effects of IAA on the cell viability and CAT activity in the mouse primary hepatocytes. Iodoacetic Acid 39-42 catalase Mus musculus 69-72 30048934-6 2018 Intracellular CAT activity significantly increased due to the stimulation of CAT production under IAA exposure. Iodoacetic Acid 98-101 catalase Mus musculus 14-17 30048934-6 2018 Intracellular CAT activity significantly increased due to the stimulation of CAT production under IAA exposure. Iodoacetic Acid 98-101 catalase Mus musculus 77-80 27853940-5 2017 In this study, we employed a monoiodoacetic acid (MIA)-induced osteoarthritic model to investigate whether osteoarthritic changes in the cartilage are reciprocally accompanied by CCN3 down-regulation and an inducible overexpression system to evaluate the effects of CCN3 on articular chondrocytes in vitro. Iodoacetic Acid 50-53 cellular communication network factor 3 Mus musculus 179-183 29812931-2 2018 Iodoacetic acid (IAA), an unregulated DBP, has been shown to be cytotoxic, mutagenic, genotoxic, and tumorigenic. Iodoacetic Acid 0-15 D-box binding PAR bZIP transcription factor Rattus norvegicus 38-41 29812931-2 2018 Iodoacetic acid (IAA), an unregulated DBP, has been shown to be cytotoxic, mutagenic, genotoxic, and tumorigenic. Iodoacetic Acid 17-20 D-box binding PAR bZIP transcription factor Rattus norvegicus 38-41 30537737-3 2018 Previously, we reported that the transient receptor potential channel vanilloid (TRPV5) is upregulated in monoiodoacetic acid (MIA)-induced OA articular cartilage. Iodoacetic Acid 106-125 transient receptor potential cation channel, subfamily V, member 5 Rattus norvegicus 81-86 30537737-3 2018 Previously, we reported that the transient receptor potential channel vanilloid (TRPV5) is upregulated in monoiodoacetic acid (MIA)-induced OA articular cartilage. Iodoacetic Acid 127-130 transient receptor potential cation channel, subfamily V, member 5 Rattus norvegicus 81-86 28844566-0 2018 Role of TrkA signalling and mast cells in the initiation of osteoarthritis pain in the monoiodoacetate model. Iodoacetic Acid 87-102 neurotrophic tyrosine kinase, receptor, type 1 Mus musculus 8-12 30281891-5 2018 Within the framework of MCA, students use these cells to determine the sensitivity of the glycolytic flux to two inhibitors (iodoacetic acid: IA, and iodoacetamide: IAA) known to act on the enzyme glyceraldehyde-3-phosphate-dehydrogenase. Iodoacetic Acid 125-140 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 197-237 29438227-0 2018 Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis. Iodoacetic Acid 137-152 transient receptor potential cation channel, subfamily V, member 4 Rattus norvegicus 17-57 29438227-3 2018 This study assessed the functional changes in TRPV4 and the expression of its endogenous ligand 5,6-epoxyeicosatrienoic acid (5,6-EET) in a rat monoiodoacetate (MIA)-induced OA pain model (MIA rats). Iodoacetic Acid 144-159 transient receptor potential cation channel, subfamily V, member 4 Rattus norvegicus 46-51 29438227-4 2018 Monoiodoacetate-treated rats showed reduced grip strength as compared to sham-treated rats, and this loss in function could be recovered by the intraarticular administration of a TRPV4 antagonist (HC067047 or GSK2193874). Iodoacetic Acid 0-15 transient receptor potential cation channel, subfamily V, member 4 Rattus norvegicus 179-184 29261292-7 2018 The monoHAAs, iodoacetic acid and bromoacetic acid, were the strongest inhibitors of GAPDH and greatly reduced cellular ATP levels. Iodoacetic Acid 14-29 glyceraldehyde-3-phosphate dehydrogenase Cricetulus griseus 85-90 29161662-6 2018 During the chloramination of IPM-containing water, CHCl2I and iodoacetic acid were the predominant iodinated trihalomethanes (I-THMs) and iodinated haloacetic acids (I-HAAs), respectively in the absence of ZVI, while CHI3 and triiodoacetic acid became the predominant ones with 1.0 g L-1 ZVI. Iodoacetic Acid 62-77 chitinase 1 Homo sapiens 217-221 28687341-8 2017 In addition, IAA-induced chemical ischemia-reperfusion stimulated TNF-alpha expression and NF-kappaB p65 phosphorylation, and these effects were attenuated by CBX. Iodoacetic Acid 13-16 tumor necrosis factor Homo sapiens 66-75 28882752-7 2017 METHOD: Sodium mono-iodoacetate (MIA) was injected in the left knee of adult male Trpv1:Cre; GFP mice. Iodoacetic Acid 8-31 transient receptor potential cation channel, subfamily V, member 1 Mus musculus 82-87 28882752-7 2017 METHOD: Sodium mono-iodoacetate (MIA) was injected in the left knee of adult male Trpv1:Cre; GFP mice. Iodoacetic Acid 33-36 transient receptor potential cation channel, subfamily V, member 1 Mus musculus 82-87 28885454-4 2017 Osteoarthritis was induced in male Wistar rats (150-175 g) by intra-articular injection of sodium monoiodoacetate (MIA; 3 mg). Iodoacetic Acid 91-113 MIA SH3 domain ER export factor 3 Rattus norvegicus 115-121 28687341-8 2017 In addition, IAA-induced chemical ischemia-reperfusion stimulated TNF-alpha expression and NF-kappaB p65 phosphorylation, and these effects were attenuated by CBX. Iodoacetic Acid 13-16 RELA proto-oncogene, NF-kB subunit Homo sapiens 91-104 25332096-0 2014 Iodoacetic acid activates Nrf2-mediated antioxidant response in vitro and in vivo. Iodoacetic Acid 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 26-30 25675406-6 2015 Pharmacological screening of prodrug in collagenase and monoiodoacetate-induced osteoarthritis at a dose of 6.8 mg/kg, (BID) exhibited significant reduction in knee diameter (p<0.001), increase in paw withdrawal latency (p<0.001), and locomotor activity (p<0.001) with significantly higher anti-inflammatory and anti-osteoarthritic activities as compared to parent drug. Iodoacetic Acid 56-71 BH3 interacting domain death agonist Rattus norvegicus 120-123 28835277-4 2017 The aim of this study was to examine the contribution of endogenous neutrophil elastase and PAR2 to the development of joint inflammation, pain, and neuropathy associated with monoiodoacetate (MIA)-induced experimental OA. Iodoacetic Acid 176-191 elastase, neutrophil expressed Mus musculus 68-87 28835277-4 2017 The aim of this study was to examine the contribution of endogenous neutrophil elastase and PAR2 to the development of joint inflammation, pain, and neuropathy associated with monoiodoacetate (MIA)-induced experimental OA. Iodoacetic Acid 176-191 coagulation factor II (thrombin) receptor-like 1 Mus musculus 92-96 26970286-0 2016 Sensitization of TRPV1 by protein kinase C in rats with mono-iodoacetate-induced joint pain. Iodoacetic Acid 56-72 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 17-22 26970286-1 2016 OBJECTIVE: To assess the functional changes of Transient receptor potential vanilloid 1 (TRPV1) receptor and to clarify its mechanism in a rat mono-iodoacetate (MIA)-induced joint pain model (MIA rats), which has joint degeneration with cartilage loss similar to osteoarthritis. Iodoacetic Acid 143-159 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 47-87 26970286-1 2016 OBJECTIVE: To assess the functional changes of Transient receptor potential vanilloid 1 (TRPV1) receptor and to clarify its mechanism in a rat mono-iodoacetate (MIA)-induced joint pain model (MIA rats), which has joint degeneration with cartilage loss similar to osteoarthritis. Iodoacetic Acid 143-159 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 89-94 26506502-8 2016 Monoiodoacetate increased the expression of matrix metalloprotinase-3 and metalloprotinase-13 in the articular cartilage and elevated the production of inflammatory markers such as tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6, but they were lower in the UCE than in the other groups (P < 0.05). Iodoacetic Acid 0-15 tumor necrosis factor Rattus norvegicus 181-208 26506502-8 2016 Monoiodoacetate increased the expression of matrix metalloprotinase-3 and metalloprotinase-13 in the articular cartilage and elevated the production of inflammatory markers such as tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6, but they were lower in the UCE than in the other groups (P < 0.05). Iodoacetic Acid 0-15 interleukin 1 beta Rattus norvegicus 210-227 26506502-8 2016 Monoiodoacetate increased the expression of matrix metalloprotinase-3 and metalloprotinase-13 in the articular cartilage and elevated the production of inflammatory markers such as tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6, but they were lower in the UCE than in the other groups (P < 0.05). Iodoacetic Acid 0-15 interleukin 6 Rattus norvegicus 233-246 26722492-0 2015 Decreased calcitonin gene-related peptide expression in the dorsal root ganglia of TNF-deficient mice in a monoiodoacetate-induced knee osteoarthritis model. Iodoacetic Acid 107-122 calcitonin/calcitonin-related polypeptide, alpha Mus musculus 10-41 25716754-0 2015 Identification of reduction-susceptible disulfide bonds in transferrin by differential alkylation using O(16)/O(18) labeled iodoacetic acid. Iodoacetic Acid 124-139 transferrin Homo sapiens 59-70 25332096-9 2014 We also examined the effects of antioxidant on Nrf2-mediated response in IAA treated cells. Iodoacetic Acid 73-76 NFE2 like bZIP transcription factor 2 Homo sapiens 47-51 24508775-6 2014 Neutralization of CGRP significantly reduced pain behavior as measured by weight bearing differential in the rat monoiodoacetate model of OA pain in a dose-dependent manner. Iodoacetic Acid 113-128 calcitonin-related polypeptide alpha Rattus norvegicus 18-22 22798269-7 2013 In the monoiodoacetate-induced rat knee joint pain model, TRPV1 protein level was significantly reduced in the ipsilateral L3-L5 DRG (33.3 %, p < 0.01), no significant difference was detected in the lumbar region of the spinal cord. Iodoacetic Acid 7-22 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 58-63 23641915-1 2013 Iodoacetic acid (IAA) and iodoform (IF) are unregulated iodinated disinfection byproducts (DBPs) found in drinking water. Iodoacetic Acid 0-15 protein tyrosine phosphatase, receptor type, N Mus musculus 17-20