PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
8457575-4	1993	Spin-labeled aminophospholipids (phosphatidylserine and phosphatidylethanolamine) were translocated to the inner vesicle membrane layer at a comparable rate as in intact red cells provided that vesicles contained enough ATP.	Phosphatidylserines	33-51	spindlin 1	Homo sapiens	0-4
8457575-5	1993	The maximum fraction of spin-labeled phospholipids translocated to the inner membrane layer was 84% for phosphatidylserine, 65% for phosphatidylethanolamine, 20-40% for phosphatidylcholine, and below 20% for sphingomyelin.	Phosphatidylserines	104-122	spindlin 1	Homo sapiens	24-28
8457575-6	1993	The apparent Km of translocation, expressed as percent of total membrane phospholipid, was 0.14% for spin-labeled phosphatidylserine and 1.19% for spin-labeled phosphatidylethanolamine.	Phosphatidylserines	114-132	spindlin 1	Homo sapiens	101-105
8490715-5	1993	PKC activity in both fractions was then measured using a novel assay based on the calcium- and lipid (phosphatidylserine and diolein)-dependent phosphorylation of the specific substrate myristoylated alanine rich C kinase substrate (MARCKS).	Phosphatidylserines	102-120	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	233-239
8443184-7	1993	The recombinants of rhodopsin with egg PC, either alone or in combination with egg PC-derived phosphatidylethanolamine (PE) or phosphatidylserine (PS), exhibited substantially reduced photochemical activity at pH 7.0.	Phosphatidylserines	127-145	rhodopsin	Bos taurus	20-29
8443184-7	1993	The recombinants of rhodopsin with egg PC, either alone or in combination with egg PC-derived phosphatidylethanolamine (PE) or phosphatidylserine (PS), exhibited substantially reduced photochemical activity at pH 7.0.	Phosphatidylserines	147-149	rhodopsin	Bos taurus	20-29
8448194-6	1993	Similar studies were performed with S-100a interacting with cardiolipin, phosphatidylserine or egg phosphatidylcholine, both in absence and in presence of 2 mM Ca2+.	Phosphatidylserines	73-91	S100 calcium binding protein A1	Homo sapiens	36-42
8429000-4	1993	In addition, we have used full time courses of prothrombin activation, in conjunction with a calculation of the equilibrium distribution of factor Xa between four enzymatic forms, to obtain the intrinsic kinetic constants of the prothrombinase assembled on PS- or PG-containing membranes.	Phosphatidylserines	257-259	coagulation factor X	Homo sapiens	229-243
7679111-5	1993	The data demonstrate that C-PAF release is dependent on cellular activation and is accompanied by alterations in the physical properties of the plasma membrane as measured by enhancement of merocyanine 540 (MC540) staining, as well as by bulk, nonspecific transbilayer movement of endogenous phospholipids as detected by the procoagulant activity of externalized phosphatidylserine (a phospholipid class usually sequestered in the plasma membrane inner leaflet).	Phosphatidylserines	363-381	PCNA clamp associated factor	Homo sapiens	28-31
7679637-2	1993	The interaction of myelin basic protein (MBP) with large unilamellar vesicles, composed of phosphatidylserine (PtdSer), phosphatidylserine/phosphatidylcholine (PtdSer/Ole2GroPCho) and phosphatidylcholine/cholesterol (Ole2GroPCho/cholesterol) was examined.	Phosphatidylserines	91-109	myelin basic protein	Homo sapiens	19-39
7679637-2	1993	The interaction of myelin basic protein (MBP) with large unilamellar vesicles, composed of phosphatidylserine (PtdSer), phosphatidylserine/phosphatidylcholine (PtdSer/Ole2GroPCho) and phosphatidylcholine/cholesterol (Ole2GroPCho/cholesterol) was examined.	Phosphatidylserines	91-109	myelin basic protein	Homo sapiens	41-44
7679637-2	1993	The interaction of myelin basic protein (MBP) with large unilamellar vesicles, composed of phosphatidylserine (PtdSer), phosphatidylserine/phosphatidylcholine (PtdSer/Ole2GroPCho) and phosphatidylcholine/cholesterol (Ole2GroPCho/cholesterol) was examined.	Phosphatidylserines	111-117	myelin basic protein	Homo sapiens	41-44
8432785-6	1993	The PKC stimulatory factor in amnion cytosol was stable to heat treatment at 80-90 C for 2 min (control + heat-treated CS, 23.20 +/- 1.2; control + heat-treated SL, 24.49 +/- 1.0 pmol/min) and substituted for phosphatidylserine and diacylglycerol in the PKC assay (control, no lipids, 0.05 +/- 0.04 pmol/min; control + amnion cytosol, no lipids, 9.60 +/- 1.06 pmol/min).	Phosphatidylserines	209-227	proline rich transmembrane protein 2	Homo sapiens	4-7
8418861-6	1993	The dependence of PKC binding on the mol % PS was highly sigmoidal.	Phosphatidylserines	43-45	proline rich transmembrane protein 2	Homo sapiens	18-21
8417975-1	1993	An effect of annexin IV and VI on the fluidity of phosphatidylserine/phosphatidylcholine (PS/PC) membranes was studied by spin labeling technique with the use of 5-doxylstearic acid.	Phosphatidylserines	50-68	surfactant protein C	Homo sapiens	90-95
8424671-1	1993	This contrasts with phosphatidylcholine/phosphatidylserine mixtures which affect the activity of PKC in a manner independent of the fatty acid composition of the phosphatidylcholine.	Phosphatidylserines	40-58	proline rich transmembrane protein 2	Homo sapiens	97-100
8382706-6	1993	The activities of HA chromatography peaks corresponding to PKC alpha, PKC beta, and PKC gamma were found to be dependent on both Ca2+ and phosphatidylserine (PtdSer), whereas, the activities of HA peaks corresponding to PKC delta and PKC zeta were Ca(2+)-independent but PtdSer-dependent.	Phosphatidylserines	138-156	protein kinase C, alpha	Mus musculus	59-68
8382706-6	1993	The activities of HA chromatography peaks corresponding to PKC alpha, PKC beta, and PKC gamma were found to be dependent on both Ca2+ and phosphatidylserine (PtdSer), whereas, the activities of HA peaks corresponding to PKC delta and PKC zeta were Ca(2+)-independent but PtdSer-dependent.	Phosphatidylserines	138-156	protein kinase C, beta	Mus musculus	70-78
8382706-6	1993	The activities of HA chromatography peaks corresponding to PKC alpha, PKC beta, and PKC gamma were found to be dependent on both Ca2+ and phosphatidylserine (PtdSer), whereas, the activities of HA peaks corresponding to PKC delta and PKC zeta were Ca(2+)-independent but PtdSer-dependent.	Phosphatidylserines	138-156	protein kinase C, gamma	Mus musculus	84-93
1330685-5	1992	We now show that negatively charged phospholipids, phosphatidylinositol, phosphatidylinositol 4,5-bisphosphate and phosphatidylserine inhibit ER protein degradation by ER-60 protease.	Phosphatidylserines	115-133	protein disulfide isomerase family A, member 3	Rattus norvegicus	168-182
1416985-1	1992	Gd3+ was evaluated as a probe for Ca2+ sites on protein kinase C (PKC) by studying its ability to replace Ca2+ in activation of PKC isozymes II (beta) and III (alpha) in the lipid systems phosphatidylserine/1,2-dioleoyl-sn-glycerol (PS/DO) and diheptanoylphosphatidylcholine (PC7)/DO.	Phosphatidylserines	188-206	GRDX	Homo sapiens	0-3
1416985-1	1992	Gd3+ was evaluated as a probe for Ca2+ sites on protein kinase C (PKC) by studying its ability to replace Ca2+ in activation of PKC isozymes II (beta) and III (alpha) in the lipid systems phosphatidylserine/1,2-dioleoyl-sn-glycerol (PS/DO) and diheptanoylphosphatidylcholine (PC7)/DO.	Phosphatidylserines	188-206	protein kinase C alpha	Homo sapiens	66-69
1331119-0	1992	Ca2+ and pH determine the interaction of chromaffin cell scinderin with phosphatidylserine and phosphatidylinositol 4,5,-biphosphate and its cellular distribution during nicotinic-receptor stimulation and protein kinase C activation.	Phosphatidylserines	72-90	scinderin	Homo sapiens	57-66
1390776-12	1992	The phosphorylated annexin I also bound to 20% phosphatidylserine/80% phosphatidylcholine vesicles at lower Ca2+ levels than the native form.	Phosphatidylserines	47-65	annexin A1	Bos taurus	19-28
1388011-0	1992	Phospholipid binding of annexin V: effects of calcium and membrane phosphatidylserine content.	Phosphatidylserines	67-85	annexin A5	Homo sapiens	24-33
1388011-1	1992	We studied the binding of fluorescein-labeled annexin V (placental anticoagulant protein I) to small unilamellar phospholipid vesicles at 0.15 M ionic strength as a function of calcium concentration and membrane phosphatidylserine (PS) content.	Phosphatidylserines	212-230	annexin A5	Homo sapiens	46-55
1388011-1	1992	We studied the binding of fluorescein-labeled annexin V (placental anticoagulant protein I) to small unilamellar phospholipid vesicles at 0.15 M ionic strength as a function of calcium concentration and membrane phosphatidylserine (PS) content.	Phosphatidylserines	232-234	annexin A5	Homo sapiens	46-55
1396703-4	1992	The affinity constants were 2 x 10(6) M-1 for cardiolipin-10N-nonyl-acridine-orange association and only 7 x 10(4) M-1 for that of phosphatidylserine and phosphatidylinositol association.	Phosphatidylserines	131-149	myoregulin	Homo sapiens	115-118
1387643-4	1992	Half-maximal inhibition of prothrombinase on and binding of annexin V to small vesicles, composed of 20% phosphatidylserine and 80% phosphatidylcholine, requires 2-3 mM calcium.	Phosphatidylserines	105-123	annexin A5	Homo sapiens	60-69
1497353-3	1992	Phosphatidylethanolamine (PE), phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylinositol (PI) also inhibit PLC delta in the presence of spermine but are much less effective than SM.	Phosphatidylserines	57-75	heparan sulfate proteoglycan 2	Homo sapiens	125-128
1497353-3	1992	Phosphatidylethanolamine (PE), phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylinositol (PI) also inhibit PLC delta in the presence of spermine but are much less effective than SM.	Phosphatidylserines	77-79	heparan sulfate proteoglycan 2	Homo sapiens	125-128
1361369-0	1992	Inhibition of phosphatidylserine synthesis induced by a CD4 mAb, B66.6 in Jurkat T cells.	Phosphatidylserines	14-32	CD4 molecule	Homo sapiens	56-59
1508194-9	1992	Autophosphorylation of immunoprecipitated nPKC theta was observed; it was enhanced by phosphatidylserine and 12-O-tetradecanoylphorbol-13-acetate but attenuated by the addition of Ca2+.	Phosphatidylserines	86-104	protein kinase C, theta	Mus musculus	42-52
1387686-1	1992	Low-angle neutron solution scattering has been used to study the structure of annexin-V and its interaction with small single-bilayer vesicles consisting of phosphatidylserine and phosphatidylcholine at a 33:66 (mol:mol) ratio.	Phosphatidylserines	157-175	annexin A5	Homo sapiens	78-87
1504105-3	1992	Cell-free phosphorylation of hsp25 required Mg2+ and ATP and was independent of Ca2+, phosphatidylserine, cAMP and cGMP.	Phosphatidylserines	86-104	heat shock protein 1	Mus musculus	29-34
1639816-3	1992	To evaluate the specificity of phosphatidylserine-containing membrane binding sites for factor VIII, we have developed a novel membrane model in which phospholipid bilayers are supported by glass microspheres (lipospheres).	Phosphatidylserines	31-49	cytochrome c oxidase subunit 8A	Homo sapiens	95-99
1639816-4	1992	The binding of fluorescein-labeled factor VIII to lipospheres with membranes of 15% phosphatidylserine was equivalent to binding to phospholipid vesicles (KD = 4.8 nM).	Phosphatidylserines	84-102	cytochrome c oxidase subunit 8A	Homo sapiens	42-46
1299619-5	1992	We examined the binding of CAP-50 to other Ca(2+)-binding proteins which have two of four EF-hand structures, by a co-precipitation assay with phospholipid (phosphatidylserine).	Phosphatidylserines	157-175	annexin A11	Homo sapiens	27-33
1440515-3	1992	Of purified PLs tested for FVIII binding, phosphatidyl serine (PS) and phosphatidic acid (PA) were highly active, phosphatidyl inositol (PI) much less so, and both phosphatidyl ethanolamine (PE) and phosphatidyl choline (PC) inactive: the apparent dissociation constant (Kd app) for FVIII binding to PS:PC vesicles showed a strong dependence on PS content.	Phosphatidylserines	63-65	coagulation factor VIII	Homo sapiens	27-32
1440515-5	1992	It is concluded that the negative charge required for FVIII binding must be presented on the phospholipid surface in the correct orientation: phosphatidyl serine supplies this charge in coagulant-active PL preparations.	Phosphatidylserines	142-161	coagulation factor VIII	Homo sapiens	54-59
1377491-0	1992	Binding of substance P to monolayers and vesicles made of phosphatidylcholine and/or phosphatidylserine.	Phosphatidylserines	85-103	tachykinin precursor 1	Homo sapiens	11-22
1377491-3	1992	Injection of SP into the aqueous subphase led to an expansion of phosphatidylcholine (PtdCho) or phosphatidylserine (PtdSer) monolayer surface area.	Phosphatidylserines	97-115	tachykinin precursor 1	Homo sapiens	13-15
1533622-5	1992	Phospholipid binding studies showed that CAP-50 bound to phosphatidylserine, phosphatidylethanolamine, phosphatidylinositol, and phosphatidic acid-containing vesicles, in a Ca(2+)-dependent manner.	Phosphatidylserines	57-75	annexin A11	Oryctolagus cuniculus	41-47
1596521-7	1992	In contrast, the protein II activity was stimulated 2-3-times more by either PG (P = 0.0024), PI (P = 0.0006) or PS (P = 0.0038).	Phosphatidylserines	113-115	annexin A4	Homo sapiens	17-27
1317308-6	1992	Structural features of both activated protein C and its substrates (coagulation factors V and VIII) are such that they require the localization of enzyme and substrate on the surface of phosphatidyl serine containing membranes for optimum activity.	Phosphatidylserines	186-205	cytochrome c oxidase subunit 8A	Homo sapiens	94-98
1323686-9	1992	In contrast, the 7-amino acid N-terminal peptide of G-protein (G.7) destabilized PS-containing membranes and not pure PC vesicles.	Phosphatidylserines	81-83	mutS homolog 5	Homo sapiens	52-66
1386949-2	1992	The inhibition of protein kinase C by CPB I was Ca(2+)-dependent, and was partially overcome by increasing the concentration of phosphatidylserine.	Phosphatidylserines	128-146	annexin A5	Homo sapiens	38-43
1311313-4	1992	Acetylation of bovine fragment 1 in the absence of Ca(II) or Mg(II) ions results in the loss of the metal ion-promoted quenching of the intrinsic Trp fluorescence of the protein and the Ca(II)-mediated binding to phosphatidylserine/phosphatidylcholine (PS/PC) vesicles.	Phosphatidylserines	213-231	carbonic anhydrase 2	Bos taurus	186-192
1531656-5	1992	Binding of these fragment 1 derivatives to phosphatidylserine/phosphatidylcholine (PS/PC) vesicles (25:75) in the presence of Ca(II) ions has been studied using the light-scattering technique.	Phosphatidylserines	43-61	carbonic anhydrase 2	Bos taurus	126-132
1311563-6	1992	Annexin-V induced a decrease of 70% of thrombomodulin activity when thrombomodulin (5.4-214 nM) was reconstituted into phosphatidylcholine/phosphatidylserine (1:1, mol/mol) vesicles at 37.5 or 75 microM-phospholipid concentration, the apparent Ki being 0.5 microM at 75 microM-lipid.	Phosphatidylserines	139-157	annexin A5	Homo sapiens	0-9
1741371-8	1992	Unlike alpha-, beta I-, beta II-, and gamma PKC, epsilon PKC was independent of Ca2+ but absolutely required phosphatidylserine and diacylglycerol for its activation; a tumor-promoting phorbol ester could replace diacylglycerol.	Phosphatidylserines	109-127	protein kinase C, gamma	Rattus norvegicus	57-60
1569041-1	1992	Phospholipase A2 activity in lysates of mast cells such as rat mastocytoma RBL-2H3 cells and mouse bone marrow-derived IL-3-dependent mast cells (BMMC) was measured using phosphatidylcholine (PC), phosphatidylethanolamine (PE), or phosphatidylserine (PS) as a substrate.	Phosphatidylserines	231-249	phospholipase A2 group IB	Rattus norvegicus	0-16
1569041-1	1992	Phospholipase A2 activity in lysates of mast cells such as rat mastocytoma RBL-2H3 cells and mouse bone marrow-derived IL-3-dependent mast cells (BMMC) was measured using phosphatidylcholine (PC), phosphatidylethanolamine (PE), or phosphatidylserine (PS) as a substrate.	Phosphatidylserines	251-253	phospholipase A2 group IB	Rattus norvegicus	0-16
1569041-2	1992	Both types of cells exhibited phospholipase A2 activity with a similar pH profile; the optimum pH observed with PS as a substrate was 5.5-7.4, whereas that with PE or PC was 8.0-9.0.	Phosphatidylserines	112-114	phospholipase A2 group IB	Rattus norvegicus	30-46
1734020-1	1992	Members of the protein kinase C (PKC) family are characterized by an NH2-terminal regulatory domain containing binding sites for calcium, phosphatidylserine, and diacylglycerol (or tumor-promoting phorbol esters), a small central hinge region and a COOH-terminal catalytic domain.	Phosphatidylserines	138-156	protein kinase C alpha	Homo sapiens	33-36
1576245-0	1992	Decreased serum level of tumor necrosis factor in animals treated with lipopolysaccharide and liposomes containing phosphatidylserine.	Phosphatidylserines	115-133	tumor necrosis factor	Mus musculus	25-46
1576245-6	1992	The data indicate that the parenteral administration of liposomes containing the aminophospholipids phosphatidylserine, and phosphatidylethanolamine is an efficient mode to reduce the endotoxin-induced production of TNF.	Phosphatidylserines	100-118	tumor necrosis factor	Mus musculus	216-219
1538715-4	1992	A fully active, Ca(2+)- and phosphatidylserine-independent, catalytic fragment of PKC that contains only the catalytic domain of the enzyme can be produced by limited proteolysis.	Phosphatidylserines	28-46	protein kinase C, alpha	Rattus norvegicus	82-85
1317973-7	1992	The results suggest that the decreased binding sites of beta-adrenoceptor in lung tissue of rat during hyperthermia may be contributed to the activation of PLA2, which then accelerated the catabolism of phospholipids such as PC and PS in the cell plasma membrane, with a consequent alteration of membrane fluidity.	Phosphatidylserines	232-234	phospholipase A2 group IB	Rattus norvegicus	156-160
1543703-5	1992	Inclusion of 9% phosphatidylserine (PS), phosphatidylglycerol (PG), or phosphatidic acid (PA) promoted the uptake by CV1 cells more than 20-fold.	Phosphatidylserines	16-34	endogenous ecotropic MuLV 1	Mus musculus	117-120
1543703-5	1992	Inclusion of 9% phosphatidylserine (PS), phosphatidylglycerol (PG), or phosphatidic acid (PA) promoted the uptake by CV1 cells more than 20-fold.	Phosphatidylserines	36-38	endogenous ecotropic MuLV 1	Mus musculus	117-120
1543703-9	1992	At least 50% PS, PG, or PI was needed to reach the level of uptake seen with CV1 cells.	Phosphatidylserines	13-15	endogenous ecotropic MuLV 1	Mus musculus	77-80
1636497-1	1992	Phospholipase A2 activity in lysates of mast cells and their related cells [mouse bone marrow-derived IL-3 dependent mast cells (BMMC), rat connective tissue mast cells (CTMC), and rat mastocytoma RBL-2H3 cells] was measured using phosphatidylethanolamine (PE), phosphatidylserine (PS), and phosphatidylcholine (PC) as exogenous substrates.	Phosphatidylserines	262-280	phospholipase A2, group IB, pancreas	Mus musculus	0-16
1636497-1	1992	Phospholipase A2 activity in lysates of mast cells and their related cells [mouse bone marrow-derived IL-3 dependent mast cells (BMMC), rat connective tissue mast cells (CTMC), and rat mastocytoma RBL-2H3 cells] was measured using phosphatidylethanolamine (PE), phosphatidylserine (PS), and phosphatidylcholine (PC) as exogenous substrates.	Phosphatidylserines	282-284	phospholipase A2, group IB, pancreas	Mus musculus	0-16
1325348-2	1992	Phosphatidylserine 800 mg/d for 10 days significantly blunted the ACTH and cortisol responses to physical exercise (P = 0.003 and P = 0.03, respectively), without affecting the rise in plasma GH and PRL.	Phosphatidylserines	0-18	proopiomelanocortin	Homo sapiens	66-70
1732721-6	1992	Stimulation of PKC alpha by phosphatidylserine was competitively inhibited by NPC 15437 (Ki = 12 +/- 4 microM).	Phosphatidylserines	28-46	protein kinase C alpha	Homo sapiens	15-24
1961199-7	1991	Multilamellar vesicles composed of either phosphatidylcholine, sphingomyelin or phosphatidylserine inhibited the binding of cytolysin to RBC at both low ionic strength and pH 6.0 indicating a lack of polar head group specificity for cytolysin binding.	Phosphatidylserines	80-98	perforin 1	Homo sapiens	124-133
1961199-7	1991	Multilamellar vesicles composed of either phosphatidylcholine, sphingomyelin or phosphatidylserine inhibited the binding of cytolysin to RBC at both low ionic strength and pH 6.0 indicating a lack of polar head group specificity for cytolysin binding.	Phosphatidylserines	80-98	perforin 1	Homo sapiens	233-242
1742461-12	1991	It is further hypothesized that PS containing membranes exert the additional specific effect of decoupling the denaturation of two subdomains of the prethrombin 1 domain of prothrombin.	Phosphatidylserines	32-34	coagulation factor II, thrombin	Bos taurus	173-184
1839615-2	1991	The phospholipid-binding properties of CPB-II were investigated by measuring the binding constants of [125I]-CPB-II using phospholipid vesicles consisting of 80% phosphatidylcholine and 20% phosphatidylserine.	Phosphatidylserines	190-208	annexin A6	Homo sapiens	39-45
1793019-2	1991	A detailed kinetic analysis of the interaction of NPC 15437 and a homogeneous preparation of PKC-alpha revealed a competitive type of inhibition with respect to activation of the enzyme by both phorbol 12-myristate 13-acetate (PMA) (Ki = 5 +/- 3 microM) and phosphatidylserine (PS) (Ki = 12 +/- 4 microM).	Phosphatidylserines	258-276	protein kinase C, alpha	Mus musculus	93-102
1793019-2	1991	A detailed kinetic analysis of the interaction of NPC 15437 and a homogeneous preparation of PKC-alpha revealed a competitive type of inhibition with respect to activation of the enzyme by both phorbol 12-myristate 13-acetate (PMA) (Ki = 5 +/- 3 microM) and phosphatidylserine (PS) (Ki = 12 +/- 4 microM).	Phosphatidylserines	278-280	protein kinase C, alpha	Mus musculus	93-102
1747478-3	1991	Tert-butyl hydroperoxide also increased relative contents of sphingomyelin, phosphatidylserine and phosphatidic acid in tumor cell membranes.	Phosphatidylserines	76-94	telomerase reverse transcriptase	Mus musculus	0-4
1663112-5	1991	However, phosphorylation of the 59 kDa protein (vimentin) in this fraction was not stimulated by adding both phosphatidyl serine and cAMP, thereby suggesting the absence of protein kinase C or of cAMP-dependent protein kinase in this fraction.	Phosphatidylserines	109-128	vimentin	Rattus norvegicus	48-56
1909124-1	1991	Optimal phosphorylation of lipid-free apo A-1 occurs in the absence of calcium, phosphatidyl serine (PS), and diolein (DO).	Phosphatidylserines	80-99	apolipoprotein A1	Homo sapiens	38-45
1909124-1	1991	Optimal phosphorylation of lipid-free apo A-1 occurs in the absence of calcium, phosphatidyl serine (PS), and diolein (DO).	Phosphatidylserines	101-103	apolipoprotein A1	Homo sapiens	38-45
1878372-9	1991	Freshly prepared Glut 1 retained high activity after separation from membrane lipids on a TSKgel G3000SW column in the presence of 40 mM octyl glucoside and 1 mM PS or PC.	Phosphatidylserines	162-164	solute carrier family 2 member 1	Homo sapiens	17-23
1878372-11	1991	The presence of a phospholipid was thus essential for retention of high activity of the Glut 1 in octyl glucoside and PC was nearly as effective as PS.	Phosphatidylserines	148-150	solute carrier family 2 member 1	Homo sapiens	88-94
1892881-3	1991	This enhancement of the cytosolic 15-lipoxygenase activity, which was reversible by EGTA, was inhibited by phosphatidyl serine and phosphatidyl choline.	Phosphatidylserines	107-126	arachidonate 15-lipoxygenase	Homo sapiens	34-49
1715284-4	1991	Furthermore, 32P from [gamma-32P]ATP was incorporated into recombinant cystatin alpha by a protein kinase C (PKC) preparation in the presence of phosphatidyl serine and Ca2+ ions as co-factors.	Phosphatidylserines	145-164	stefin A3	Rattus norvegicus	71-85
1744985-3	1991	At a concentration of 0.03 U, the action of phospholipase A2 resulted in the splitting of phosphatidylserine (PS), choline phosphatides (PC) and ethanolamine phosphatides (PE) by about 32, 34 and 65%, respectively, and reduced [3H]ligand binding by about 32%.	Phosphatidylserines	90-108	phospholipase A2 group IB	Rattus norvegicus	44-60
1744985-3	1991	At a concentration of 0.03 U, the action of phospholipase A2 resulted in the splitting of phosphatidylserine (PS), choline phosphatides (PC) and ethanolamine phosphatides (PE) by about 32, 34 and 65%, respectively, and reduced [3H]ligand binding by about 32%.	Phosphatidylserines	110-112	phospholipase A2 group IB	Rattus norvegicus	44-60
1903207-10	1991	We conclude that insulin, DOCA, and CO2 may stimulated H+ excretion in toad bladder in part by increasing turnover of membrane PL, PC, and phosphatidylinositol, and in the case of CO2, phosphatidic acid plus phosphatidylserine as well, but not PC.	Phosphatidylserines	208-226	insulin	Homo sapiens	17-24
1685336-5	1991	The use of a CD2 mAb, D66, able to mobilize exclusively Ca2+ from intracellular stores, resulted in 51% inhibition of PS synthesis.	Phosphatidylserines	118-120	CD2 molecule	Homo sapiens	13-16
1685336-6	1991	N-Ethylmaleimide (NEM), which inhibits both the release of Ca2+ from internal stores and the influx of Ca2+, totally prevents the inhibition of PS synthesis induced by PHA, anti-CD3 or anti-CD2 mAbs.	Phosphatidylserines	144-146	CD2 molecule	Homo sapiens	190-193
1685336-9	1991	Taken together, these results show that the inhibition of PS synthesis induced by T cell activators is regulated by both calmodulin and Ca2+ ions recruited from intracellular compartments.	Phosphatidylserines	58-60	calmodulin 1	Homo sapiens	121-131
1826685-7	1991	In the presence of calmodulin, the binding of neuromodulin to phosphatidylserine is inhibited, resulting in total inhibition of neuromodulin phosphorylation.	Phosphatidylserines	62-80	calmodulin 1	Homo sapiens	19-29
1826685-7	1991	In the presence of calmodulin, the binding of neuromodulin to phosphatidylserine is inhibited, resulting in total inhibition of neuromodulin phosphorylation.	Phosphatidylserines	62-80	growth associated protein 43	Homo sapiens	46-58
1826685-7	1991	In the presence of calmodulin, the binding of neuromodulin to phosphatidylserine is inhibited, resulting in total inhibition of neuromodulin phosphorylation.	Phosphatidylserines	62-80	growth associated protein 43	Homo sapiens	128-140
1652682-6	1991	Moreover, MS2 RNA, lambda DNA, t-RNA, dGTP, Phosphatidyl serine, phosphatidyl inositol, antipain, and chymostatin exerted inhibitory proteolytic effect on histone VIII-S.	Phosphatidylserines	44-63	MS2	Homo sapiens	10-13
2007589-12	1991	The mechanism by which pssC complements the defect of PSA-3 in phosphatidylserine biosynthesis is discussed.	Phosphatidylserines	63-81	phosphatidylserine decarboxylase proenzyme, mitochondrial	Cricetulus griseus	23-27
2002338-6	1991	The PKC activity in the particulate fraction measured in vitro by histone IIIS phosphorylation in the presence of calcium, 4 beta-phorbol 13-myristate 12-acetate, and phosphatidylserine (PS) significantly decreased by 52% during ischemia, and remained depressed over the 48-h reperfusion period.	Phosphatidylserines	167-185	protein kinase C, alpha	Rattus norvegicus	4-7
2002338-6	1991	The PKC activity in the particulate fraction measured in vitro by histone IIIS phosphorylation in the presence of calcium, 4 beta-phorbol 13-myristate 12-acetate, and phosphatidylserine (PS) significantly decreased by 52% during ischemia, and remained depressed over the 48-h reperfusion period.	Phosphatidylserines	187-189	protein kinase C, alpha	Rattus norvegicus	4-7
1654774-9	1991	In the presence of phosphatidylserine, the catalytic site was selectively modified by periodate, resulting in formation of a form of PKC that exhibited phorbol ester binding but not kinase activity.	Phosphatidylserines	19-37	proline rich transmembrane protein 2	Homo sapiens	133-136
2000640-7	1991	Incorporation of exogenous PS into pulmonary artery endothelial cells mimicked the stimulatory effect of NO2 on PLA1 activity.	Phosphatidylserines	27-29	POU class 2 homeobox 3	Homo sapiens	112-116
2000640-9	1991	The NO2-induced increase of PS in the plasma membranes appears to be responsible for the specific activation of PLA1 in pulmonary artery endothelial cells.	Phosphatidylserines	28-30	POU class 2 homeobox 3	Homo sapiens	112-116
2015419-10	1991	Evidence has been obtained that a large fraction of PS is hydrolyzed at the injection site, probably by phospholipase A2 and other hydrolytic enzymes released by platelets.	Phosphatidylserines	52-54	phospholipase A2 group IB	Rattus norvegicus	104-120
2051897-2	1991	Hexadecylphocholine (He-PC2), the APC prototype, inhibited PKC competitively with respect to phosphatidylserine an noncompetitively with respect to CaCl2, both with an apparent Ki of about 15 microM.	Phosphatidylserines	93-111	chromobox 4	Homo sapiens	24-27
1985909-2	1991	PKC association to a mixed phospholipid film (phosphatidylcholine, phosphatidylserine) could be detected by an increase of the monolayer surface pressure.	Phosphatidylserines	67-85	proline rich transmembrane protein 2	Homo sapiens	0-3
1991158-8	1991	These results suggest that an eicosanoid-independent degradation of phosphatidylethanolamine via phospholipase A2 at lower collagen levels may provide a source of the initial AA for conversion to TxA2 and the subsequent deacylation of phosphatidylinositol, phosphatidylcholine, and also phosphatidylserine.	Phosphatidylserines	287-305	phospholipase A2 group IB	Homo sapiens	97-113
1908615-3	1991	The kinetics of activation of synapsin I phosphorylation by acidic phospholipids, phosphatidylserine and phosphatidylinositol, in the absence and presence of phosphatidylinositol-4,5-bisphosphate and diacylglycerol was compared.	Phosphatidylserines	82-100	synapsin I	Homo sapiens	30-40
1782102-8	1991	Although the proportion of phosphatidylserine and phosphatidylinositol and lysophospholipids tended to be reduced in the Hyp/Y bones, the absence of other statistically significant phospholipid abnormalities in the bones and brains of these animals suggests that the lipid defect is not systemic, but is associated with a decrease in phosphate at the site of bone formation.	Phosphatidylserines	27-45	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	121-124
2257300-4	1990	In the presence of factors VIIa, Xa, and LACI, complete inhibition of tissue factor was observed on both phosphatidylcholine (neutral surfaces) and on phosphatidylserine/phosphatidylcholine (acidic) surfaces; omission of factors Xa or LACI resulted in no inhibition.	Phosphatidylserines	151-169	tissue factor pathway inhibitor	Homo sapiens	41-45
2257300-4	1990	In the presence of factors VIIa, Xa, and LACI, complete inhibition of tissue factor was observed on both phosphatidylcholine (neutral surfaces) and on phosphatidylserine/phosphatidylcholine (acidic) surfaces; omission of factors Xa or LACI resulted in no inhibition.	Phosphatidylserines	151-169	coagulation factor III, tissue factor	Homo sapiens	70-83
2172248-6	1990	The activities of DGK-II and DGK-III were markedly enhanced by the presence of deoxycholate or phosphatidylserine, whereas DGK-I activity was not much affected by the anionic compounds.	Phosphatidylserines	95-113	diacylglycerol kinase beta	Homo sapiens	18-21
2172248-6	1990	The activities of DGK-II and DGK-III were markedly enhanced by the presence of deoxycholate or phosphatidylserine, whereas DGK-I activity was not much affected by the anionic compounds.	Phosphatidylserines	95-113	diacylglycerol kinase beta	Homo sapiens	29-32
2172248-6	1990	The activities of DGK-II and DGK-III were markedly enhanced by the presence of deoxycholate or phosphatidylserine, whereas DGK-I activity was not much affected by the anionic compounds.	Phosphatidylserines	95-113	diacylglycerol kinase iota	Homo sapiens	18-23
2280670-3	1990	Phosphatidylserine at 10 mol% increased the initial rate of spontaneous and of SCP2-mediated (but not FABP-mediated) sterol exchange by 22% and 44-fold, respectively.	Phosphatidylserines	0-18	sterol carrier protein 2	Homo sapiens	79-83
2280670-4	1990	The SCP2 potentiation of sterol transfer was dependent on SCP2 concentration and on phosphatidylserine concentration.	Phosphatidylserines	84-102	sterol carrier protein 2	Homo sapiens	4-8
2084499-6	1990	Diffusion was found to play a major limiting role in FXa production for TF:30% phosphatidylserine (PS)/70% phosphatidylcholine (PC) surfaces.	Phosphatidylserines	79-97	coagulation factor X	Homo sapiens	53-56
2084499-6	1990	Diffusion was found to play a major limiting role in FXa production for TF:30% phosphatidylserine (PS)/70% phosphatidylcholine (PC) surfaces.	Phosphatidylserines	79-97	coagulation factor III, tissue factor	Homo sapiens	72-74
2084499-6	1990	Diffusion was found to play a major limiting role in FXa production for TF:30% phosphatidylserine (PS)/70% phosphatidylcholine (PC) surfaces.	Phosphatidylserines	99-101	coagulation factor X	Homo sapiens	53-56
2084499-6	1990	Diffusion was found to play a major limiting role in FXa production for TF:30% phosphatidylserine (PS)/70% phosphatidylcholine (PC) surfaces.	Phosphatidylserines	99-101	coagulation factor III, tissue factor	Homo sapiens	72-74
2145274-8	1990	Phospholipid vesicles containing phosphatidylserine completely inhibited binding of annexin V to platelets.	Phosphatidylserines	33-51	annexin A5	Homo sapiens	84-93
2254963-7	1990	Likewise phosphorylation of GFAP was also accentuated by calcium/phosphatidylserine/diolein and by exogenous cyclic AMP-dependent kinase in a cell free system.	Phosphatidylserines	65-83	glial fibrillary acidic protein	Homo sapiens	28-32
2207117-1	1990	An assay for procoagulant activity has been used to investigate the Ca2(+)-dependent exposure of phosphatidylserine at the surface of human erythrocytes that were induced to swell and to fuse osmotically.	Phosphatidylserines	97-115	carbonic anhydrase 2	Homo sapiens	68-71
2398047-9	1990	Both the p76-kinase-catalyzed phosphorylation of histone III-S and the autophosphorylation of the enzyme could be activated by the phorbol ester TPA (or diacylglycerol) plus phosphatidyl serine, but not by calcium plus phosphatidyl serine.	Phosphatidylserines	174-193	phospholipase B domain containing 2	Mus musculus	9-12
2398047-9	1990	Both the p76-kinase-catalyzed phosphorylation of histone III-S and the autophosphorylation of the enzyme could be activated by the phorbol ester TPA (or diacylglycerol) plus phosphatidyl serine, but not by calcium plus phosphatidyl serine.	Phosphatidylserines	219-238	phospholipase B domain containing 2	Mus musculus	9-12
2252889-2	1990	We studied the interaction of transferrin receptors (of cell line Molt-4) with mixed model membranes as a function of lipid chain length (phospholipids with C14:0 and C18:1 hydrocarbon chains) and of the surface charge of the membrane using mixtures of C14:0 lecithin (DMPC) with C14:0 phosphatidylglycerol (DMPG) and C14:0 phosphatidylserine (DMPS).	Phosphatidylserines	324-342	transferrin	Homo sapiens	30-41
2261453-7	1990	For PS and to a lesser extent for PA we propose that the formation of a coordinated complex (chelate complex) with Ca2+ as central ion and ligands provided by the gamma-carboxyglutamic acid residues of prothrombin and factor Xa and the polar head group of phospholipids is the major driving force in protein-membrane association.	Phosphatidylserines	4-6	coagulation factor II, thrombin	Homo sapiens	202-213
2390065-6	1990	Phosphatidylserine binding to PS-p68 was inhibited by phosphatidic acid and by alkylphospholipids.	Phosphatidylserines	0-18	caveolae associated protein 2	Homo sapiens	30-36
2143194-4	1990	The binding of BB myosin I to phosphatidylserine and phosphatidylglycerol vesicles reached saturation at 4-5 x 10(-3) nmol protein/nmol phospholipid, while the apparent dissociation constant was determined to be 1-3 x 10(-7) M. Similar to the free protein, membrane-associated BB myosin I bound F-actin in an ATP-sensitive manner and demonstrated actin-activated Mg-ATPase activity.	Phosphatidylserines	30-48	myosin IA	Homo sapiens	15-26
2162826-3	1990	This study shows that the activity of adseverin is inhibited not only by PIP2 but also by some common phospholipids including phosphatidylinositol (PI) and phosphatidylserine (PS).	Phosphatidylserines	156-174	scinderin	Bos taurus	38-47
2162826-3	1990	This study shows that the activity of adseverin is inhibited not only by PIP2 but also by some common phospholipids including phosphatidylinositol (PI) and phosphatidylserine (PS).	Phosphatidylserines	176-178	scinderin	Bos taurus	38-47
2164217-4	1990	Yeast PKC was activated by the simultaneous addition of Ca2+, diacylglycerol, and phosphatidylserine.	Phosphatidylserines	82-100	protein kinase C	Saccharomyces cerevisiae S288C	6-9
2365066-1	1990	The inactivation of bovine heart glyceraldehyde-3-phosphate dehydrogenase by phosphatidylinositol (PI) and phosphatidylserine (PS) in the form of liposomes was investigated in the presence and absence of NAD excess.	Phosphatidylserines	107-125	LOC786101	Bos taurus	33-73
2365066-1	1990	The inactivation of bovine heart glyceraldehyde-3-phosphate dehydrogenase by phosphatidylinositol (PI) and phosphatidylserine (PS) in the form of liposomes was investigated in the presence and absence of NAD excess.	Phosphatidylserines	127-129	LOC786101	Bos taurus	33-73
2116167-5	1990	Phosphatidylethanolamine or stearylamine, having a positively charged group, reduced the catalytic efficiency of t-PA by raising its Km value (10-fold), whereas negatively charged phospholipids, phosphatidylserine and phosphatidylinositol, did not affect the efficiency.	Phosphatidylserines	195-213	plasminogen activator, tissue type	Homo sapiens	113-117
2394581-1	1990	Phosphatidylserine (PS) is a necessary cofactor for protein kinase C (PKC) activation, and changes in the synthesis of PS have been shown to participate in the mechanism(s) involved in the transmembrane signaling of interleukin 1 (IL-1).	Phosphatidylserines	0-18	interleukin 1 alpha	Homo sapiens	216-236
2394581-1	1990	Phosphatidylserine (PS) is a necessary cofactor for protein kinase C (PKC) activation, and changes in the synthesis of PS have been shown to participate in the mechanism(s) involved in the transmembrane signaling of interleukin 1 (IL-1).	Phosphatidylserines	20-22	interleukin 1 alpha	Homo sapiens	216-236
2394581-1	1990	Phosphatidylserine (PS) is a necessary cofactor for protein kinase C (PKC) activation, and changes in the synthesis of PS have been shown to participate in the mechanism(s) involved in the transmembrane signaling of interleukin 1 (IL-1).	Phosphatidylserines	119-121	interleukin 1 alpha	Homo sapiens	216-236
2394581-3	1990	Furthermore, the effect of an in vitro treatment with PS in human peripheral blood monocytes (PBMC) or splenocytes activated with a lectin mitogen, on the expression of IL-2 receptor, was assessed.	Phosphatidylserines	54-56	interleukin 2 receptor subunit beta	Homo sapiens	169-182
2394581-6	1990	While only a pharmacological concentration (10(-5) M) of PS significantly increased IL-2 receptor expression in activated human PBMC, simultaneous treatment of PBMC with inactive doses of PS and the pharmacological activator of PKC (phorbol myristate acetate, PMA, 10(-8) M) resulted in a synergistic stimulation of Tac+ cells.	Phosphatidylserines	57-59	interleukin 2 receptor subunit beta	Homo sapiens	84-97
2394581-7	1990	Furthermore, in cultures of rat splenocytes PS (10(-6) M) significantly stimulated the expression of IL-2 receptor, and concomitant addition of PS (10(-7) M) to Con A-stimulated splenocytes produced a significant potentiation of IL-2 receptor induction.	Phosphatidylserines	44-46	interleukin 2 receptor subunit beta	Homo sapiens	101-114
2394581-10	1990	The in vitro effects of the phospholipid on human PBMC and rat splenocytes might suggest that PS is implicated in T-cell activation through its action on IL-2 receptor.	Phosphatidylserines	94-96	interleukin 2 receptor subunit beta	Homo sapiens	154-167
2398032-3	1990	Phosphorylated truncated pre IL 1 alpha selectively binds to acidic phospholipids including phosphatidic acid, phosphatidylserine, and phosphatidylinositol, but not to other phospholipids (phosphatidylcholine and phosphatidylethanolamine).	Phosphatidylserines	111-129	interleukin 1 alpha	Homo sapiens	29-39
2398032-5	1990	In order to obtain half-maximal binding of pre IL 1 alpha to phosphatidic acid or phosphatidylserine, Ca2+ between 5 and 100 microM was required.	Phosphatidylserines	82-100	interleukin 1 alpha	Homo sapiens	47-57
2315927-11	1990	These data demonstrate that phenobarbital pretreatment is associated with a shift in the predominant phospholipid locus from phosphatidylserine to phosphatidylethanolamine for the early CCl4-induced fatty acid changes in rat liver microsomes.	Phosphatidylserines	125-143	C-C motif chemokine ligand 4	Rattus norvegicus	186-190
1968066-7	1990	PK-1 phosphorylation of two endogenous proteins is, however, greatly enhanced in the presence of phosphatidylserine or phosphatidyl-inositol.	Phosphatidylserines	97-115	pyruvate kinase L/R	Homo sapiens	0-4
2303476-2	1990	Equilibrium binding studies of prothrombinase complex formation were undertaken using phospholipid vesicles composed of phosphatidylcholine and phosphatidylserine (PCPS), factor Va, and factor Xa modified with dansyl glutamylglycinylarginyl chloromethyl ketone (DEGR.Xa).	Phosphatidylserines	144-162	coagulation factor X	Homo sapiens	31-45
2109710-6	1990	The decrease in total PKC activity was accompanied by an increase in Ca2+, phosphatidylserine (PS), diacylglycerol (DG)-insensitive activity suggesting the release of a portion of the catalytic domain of PKC (M-kinase) by the phorbol ester treatment.	Phosphatidylserines	75-93	protein kinase C, gamma	Rattus norvegicus	22-25
2109710-6	1990	The decrease in total PKC activity was accompanied by an increase in Ca2+, phosphatidylserine (PS), diacylglycerol (DG)-insensitive activity suggesting the release of a portion of the catalytic domain of PKC (M-kinase) by the phorbol ester treatment.	Phosphatidylserines	95-97	protein kinase C, gamma	Rattus norvegicus	22-25
2155616-5	1990	Addition of a lower amount of either phosphatidylserine or sodium oleate to the reaction mixture was efficacious in attenuating the inhibition of the CaM-PDE by W-7, chlorpromazine, trifluoperazine, compound 48/80, or R-24571 but, in contrast, had little or no effect on the inhibition by K-259-2 or KS-619-1.	Phosphatidylserines	37-55	calmodulin	Bos taurus	150-153
2138016-3	1990	The Ca2+ requirement for all of the proteins was lowest for binding to vesicles composed of phosphatidic acid, followed by phosphatidylserine and then phosphatidylinositol.	Phosphatidylserines	123-141	carbonic anhydrase 2	Homo sapiens	4-7
2138016-5	1990	Both calpactin I heavy chain and lipocortin I promoted aggregation of phosphatidylserine- or phosphatidylinositol-containing vesicles in the presence of less than 10 microM-Ca2+.	Phosphatidylserines	70-88	annexin A2	Homo sapiens	5-28
2295617-2	1990	The acidic phospholipids such as phosphatidylserine (PS), phosphatidic acid, phosphatidyl-glycerol, and cardiolipin, which are activators of PKC in the assay of protein phosphorylation, could differentially inactivate PKC I, II, and III during preincubation in the absence of divalent cation.	Phosphatidylserines	33-51	protein kinase C iota	Homo sapiens	141-144
2295617-2	1990	The acidic phospholipids such as phosphatidylserine (PS), phosphatidic acid, phosphatidyl-glycerol, and cardiolipin, which are activators of PKC in the assay of protein phosphorylation, could differentially inactivate PKC I, II, and III during preincubation in the absence of divalent cation.	Phosphatidylserines	33-51	protein kinase C iota	Homo sapiens	218-236
2295617-2	1990	The acidic phospholipids such as phosphatidylserine (PS), phosphatidic acid, phosphatidyl-glycerol, and cardiolipin, which are activators of PKC in the assay of protein phosphorylation, could differentially inactivate PKC I, II, and III during preincubation in the absence of divalent cation.	Phosphatidylserines	53-55	protein kinase C iota	Homo sapiens	141-144
2295617-12	1990	In the presence of divalent cations, PS interacted preferentially with the regulatory domain of PKC and resulted in the activation of the kinase.	Phosphatidylserines	37-39	protein kinase C iota	Homo sapiens	96-99
2112913-1	1990	For elucidation of the role of phosphatidylserine (PS) in the membrane actions of human recombinant tumor necrosis factor (TNF) and interferons (IFNs) alpha and gamma, the actions of these cytokines on liposome membranes containing PS were compared with those on liposome membranes containing two other anionic phospholipids, phosphatidylglycerol (PG) and phosphatidic acid (PA).	Phosphatidylserines	51-53	tumor necrosis factor	Homo sapiens	100-121
2112913-1	1990	For elucidation of the role of phosphatidylserine (PS) in the membrane actions of human recombinant tumor necrosis factor (TNF) and interferons (IFNs) alpha and gamma, the actions of these cytokines on liposome membranes containing PS were compared with those on liposome membranes containing two other anionic phospholipids, phosphatidylglycerol (PG) and phosphatidic acid (PA).	Phosphatidylserines	51-53	tumor necrosis factor	Homo sapiens	123-126
2158363-8	1990	Cis- and trans-tamoxifen inhibited the Ca2(+)- and phosphatidylserine- (PS-) dependent activity of purified rat brain PKC with indistinguishable potencies, but cis-tamoxifen was somewhat more potent than the trans isomer in the inhibition of the Ca2(+)- and PS-independent activity of PKC.	Phosphatidylserines	51-69	protein kinase C, gamma	Rattus norvegicus	118-121
2144763-1	1990	The ability of purified protein kinase C (PKC) to phosphorylate protamine sulphate was found to be totally independent of phospholipid cofactors, whereas the phosphorylation of protamine free base was markedly increased by the presence of phosphatidylserine (PS).	Phosphatidylserines	239-257	proline rich transmembrane protein 2	Homo sapiens	24-40
2144763-1	1990	The ability of purified protein kinase C (PKC) to phosphorylate protamine sulphate was found to be totally independent of phospholipid cofactors, whereas the phosphorylation of protamine free base was markedly increased by the presence of phosphatidylserine (PS).	Phosphatidylserines	239-257	proline rich transmembrane protein 2	Homo sapiens	42-45
2144763-1	1990	The ability of purified protein kinase C (PKC) to phosphorylate protamine sulphate was found to be totally independent of phospholipid cofactors, whereas the phosphorylation of protamine free base was markedly increased by the presence of phosphatidylserine (PS).	Phosphatidylserines	259-261	proline rich transmembrane protein 2	Homo sapiens	24-40
2144763-1	1990	The ability of purified protein kinase C (PKC) to phosphorylate protamine sulphate was found to be totally independent of phospholipid cofactors, whereas the phosphorylation of protamine free base was markedly increased by the presence of phosphatidylserine (PS).	Phosphatidylserines	259-261	proline rich transmembrane protein 2	Homo sapiens	42-45
1713890-2	1990	Using 2,4,6-trinitrobenzenesulfonic acid (TNBS), bee venom phospholipase A2 and merocyanine 540 binding, we have demonstrated that in RBC of patient more than 50% of PS is redistributed into the outer leaflet of the plasma membrane.	Phosphatidylserines	166-168	phospholipase A2 group IB	Homo sapiens	59-75
2092043-0	1990	Mechanism of phosphatidylserine-induced inhibition of interleukin 2 synthesis in the human T cell line Jurkat.	Phosphatidylserines	13-31	interleukin 2	Homo sapiens	54-67
2136706-4	1990	The p68 and p32 from porcine brain bind to phosphatidic acid (half-maximal binding at 6 and 34 microM free calcium, respectively) and to phosphatidylserine (8 and 34 microM, respectively).	Phosphatidylserines	137-155	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	4-7
2136706-4	1990	The p68 and p32 from porcine brain bind to phosphatidic acid (half-maximal binding at 6 and 34 microM free calcium, respectively) and to phosphatidylserine (8 and 34 microM, respectively).	Phosphatidylserines	137-155	inhibitor of growth family member 2	Homo sapiens	12-15
33821543-2	2021	ATP8a1, a protein involved in the translocation of phosphatidylserine and phosphatidylethanolamine across lipid bilayers, is the strongest binding partner of IFT27.	Phosphatidylserines	51-69	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	Mus musculus	0-6
33821543-2	2021	ATP8a1, a protein involved in the translocation of phosphatidylserine and phosphatidylethanolamine across lipid bilayers, is the strongest binding partner of IFT27.	Phosphatidylserines	51-69	intraflagellar transport 27	Mus musculus	158-163
33818240-4	2021	Osmotic swelling mediated by AQP1 sustains the calcium entry required for platelet phosphatidylserine exposure and microvesiculation, through calcium permeable stretch-activated or mechanosensitive cation channels.	Phosphatidylserines	83-101	aquaporin 1 (Colton blood group)	Homo sapiens	29-33
33794068-4	2021	We showed that SMAC/Diablo directly interacts with mitochondrial phosphatidylserine decarboxylase (PSD) and inhibits its catalytic activity during synthesis of phosphatidylethanolamine (PE) from phosphatidylserine (PS).	Phosphatidylserines	65-83	diablo IAP-binding mitochondrial protein	Homo sapiens	15-19
33794068-4	2021	We showed that SMAC/Diablo directly interacts with mitochondrial phosphatidylserine decarboxylase (PSD) and inhibits its catalytic activity during synthesis of phosphatidylethanolamine (PE) from phosphatidylserine (PS).	Phosphatidylserines	65-83	diablo IAP-binding mitochondrial protein	Homo sapiens	20-26
33794068-4	2021	We showed that SMAC/Diablo directly interacts with mitochondrial phosphatidylserine decarboxylase (PSD) and inhibits its catalytic activity during synthesis of phosphatidylethanolamine (PE) from phosphatidylserine (PS).	Phosphatidylserines	65-83	F-box and leucine rich repeat protein 15	Homo sapiens	99-102
33794068-4	2021	We showed that SMAC/Diablo directly interacts with mitochondrial phosphatidylserine decarboxylase (PSD) and inhibits its catalytic activity during synthesis of phosphatidylethanolamine (PE) from phosphatidylserine (PS).	Phosphatidylserines	195-213	diablo IAP-binding mitochondrial protein	Homo sapiens	15-19
33794068-4	2021	We showed that SMAC/Diablo directly interacts with mitochondrial phosphatidylserine decarboxylase (PSD) and inhibits its catalytic activity during synthesis of phosphatidylethanolamine (PE) from phosphatidylserine (PS).	Phosphatidylserines	195-213	diablo IAP-binding mitochondrial protein	Homo sapiens	20-26
33794068-4	2021	We showed that SMAC/Diablo directly interacts with mitochondrial phosphatidylserine decarboxylase (PSD) and inhibits its catalytic activity during synthesis of phosphatidylethanolamine (PE) from phosphatidylserine (PS).	Phosphatidylserines	195-213	F-box and leucine rich repeat protein 15	Homo sapiens	99-102
33794068-4	2021	We showed that SMAC/Diablo directly interacts with mitochondrial phosphatidylserine decarboxylase (PSD) and inhibits its catalytic activity during synthesis of phosphatidylethanolamine (PE) from phosphatidylserine (PS).	Phosphatidylserines	99-101	diablo IAP-binding mitochondrial protein	Homo sapiens	15-19
33794068-4	2021	We showed that SMAC/Diablo directly interacts with mitochondrial phosphatidylserine decarboxylase (PSD) and inhibits its catalytic activity during synthesis of phosphatidylethanolamine (PE) from phosphatidylserine (PS).	Phosphatidylserines	99-101	diablo IAP-binding mitochondrial protein	Homo sapiens	20-26
33801886-2	2021	TAM receptor activation is induced upon binding of the ligands protein S (Pros1) or growth arrest-specific protein 6 (Gas6) which act as bridging molecules for binding of phosphatidyl serine (PtdSer) exposed on apoptotic cell membranes.	Phosphatidylserines	192-198	growth arrest specific 6	Mus musculus	84-116
33801886-2	2021	TAM receptor activation is induced upon binding of the ligands protein S (Pros1) or growth arrest-specific protein 6 (Gas6) which act as bridging molecules for binding of phosphatidyl serine (PtdSer) exposed on apoptotic cell membranes.	Phosphatidylserines	192-198	growth arrest specific 6	Mus musculus	118-122
33800462-7	2021	The shedding function of ADAM10 can be blocked through inhibition of its interaction with surface exposed phosphatidylserine (PS), and this effectively inhibited sCD137 generation.	Phosphatidylserines	106-124	ADAM metallopeptidase domain 10	Homo sapiens	25-31
33800462-7	2021	The shedding function of ADAM10 can be blocked through inhibition of its interaction with surface exposed phosphatidylserine (PS), and this effectively inhibited sCD137 generation.	Phosphatidylserines	126-128	ADAM metallopeptidase domain 10	Homo sapiens	25-31
33800462-8	2021	The phospholipid scramblase Anoctamin-6 (ANO6) traffics PS to the outer membrane and thus modifies ADAM10 function.	Phosphatidylserines	56-58	anoctamin 6	Homo sapiens	28-39
33800462-8	2021	The phospholipid scramblase Anoctamin-6 (ANO6) traffics PS to the outer membrane and thus modifies ADAM10 function.	Phosphatidylserines	56-58	anoctamin 6	Homo sapiens	41-45
33800462-8	2021	The phospholipid scramblase Anoctamin-6 (ANO6) traffics PS to the outer membrane and thus modifies ADAM10 function.	Phosphatidylserines	56-58	ADAM metallopeptidase domain 10	Homo sapiens	99-105
33806352-7	2021	cAMP-induced changes in lipid composition included an increase in phosphatidylserine and cardiolipin levels in PAM and PM compartments, respectively; an increase in phosphatidylinositol in the ER, mitochondria, and MAMs; and a reorganization of phosphatidic acid, cholesterol ester, ceramide, and phosphatidylethanolamine.	Phosphatidylserines	66-84	peptidylglycine alpha-amidating monooxygenase	Mus musculus	111-114
33234244-7	2020	Current evidences suggest that these modifications help Gas6/Pros1 to achieve optimal PtdSer-binding capacities.	Phosphatidylserines	86-92	growth arrest specific 6	Homo sapiens	56-60
33234245-2	2020	Along with their ligands, Gas6 and ProteinS, TAMs acts as receptors to phosphatidylserine (PtdSer), an anionic phospholipid that becomes externalized on the surface of apoptotic and stressed cells.	Phosphatidylserines	71-89	growth arrest specific 6	Mus musculus	26-30
33234245-2	2020	Along with their ligands, Gas6 and ProteinS, TAMs acts as receptors to phosphatidylserine (PtdSer), an anionic phospholipid that becomes externalized on the surface of apoptotic and stressed cells.	Phosphatidylserines	91-97	growth arrest specific 6	Mus musculus	26-30
33234246-4	2020	Multiple PS receptors (PSRs) mediate this process including members from the TAM (Tyro3, Axl, Mertk) receptor Tyrosine kinases (RTKs) by interacting with PS via bridging proteins like Gas6 and ProS1.	Phosphatidylserines	9-11	TYRO3 protein tyrosine kinase	Homo sapiens	82-87
33234246-4	2020	Multiple PS receptors (PSRs) mediate this process including members from the TAM (Tyro3, Axl, Mertk) receptor Tyrosine kinases (RTKs) by interacting with PS via bridging proteins like Gas6 and ProS1.	Phosphatidylserines	9-11	AXL receptor tyrosine kinase	Homo sapiens	89-92
33234246-4	2020	Multiple PS receptors (PSRs) mediate this process including members from the TAM (Tyro3, Axl, Mertk) receptor Tyrosine kinases (RTKs) by interacting with PS via bridging proteins like Gas6 and ProS1.	Phosphatidylserines	9-11	MER proto-oncogene, tyrosine kinase	Homo sapiens	94-99
33234246-4	2020	Multiple PS receptors (PSRs) mediate this process including members from the TAM (Tyro3, Axl, Mertk) receptor Tyrosine kinases (RTKs) by interacting with PS via bridging proteins like Gas6 and ProS1.	Phosphatidylserines	9-11	growth arrest specific 6	Homo sapiens	184-188
33234246-4	2020	Multiple PS receptors (PSRs) mediate this process including members from the TAM (Tyro3, Axl, Mertk) receptor Tyrosine kinases (RTKs) by interacting with PS via bridging proteins like Gas6 and ProS1.	Phosphatidylserines	9-11	protein S	Homo sapiens	193-198
19283471-5	2009	The specific target of this strategy has been the enzyme activity termed aminophospholipid translocase (APLT) or flippase that causes translocation of phosphatidylserine (PS) from the outer to the inner leaflet of the plasma membrane in viable cells.	Phosphatidylserines	151-169	ATPase phospholipid transporting 8A1	Homo sapiens	73-102
19283471-5	2009	The specific target of this strategy has been the enzyme activity termed aminophospholipid translocase (APLT) or flippase that causes translocation of phosphatidylserine (PS) from the outer to the inner leaflet of the plasma membrane in viable cells.	Phosphatidylserines	151-169	ATPase phospholipid transporting 8A1	Homo sapiens	104-108
10767630-1	2000	Activity of protein kinase C (PKC) depends on the interaction with polar head-groups of two membrane lipids, i.e., phosphatidylserine and diacylglycerol.	Phosphatidylserines	115-133	protein kinase C delta	Homo sapiens	30-33
34873731-2	2022	A dynamic lipidomics approach revealed that mitochondria preferentially import di-unsaturated phosphatidylserine (PS) for subsequent conversion to PE by the mitochondrial PS decarboxylase Psd1p.	Phosphatidylserines	114-116	phosphatidylserine decarboxylase 1	Saccharomyces cerevisiae S288C	188-193
34651249-1	2022	One of the physiologic mechanisms responsible to maintain asymmetric phospholipid distribution (in particular phosphatidylserine, PS) in human erythrocyte membranes is orchestrated by the balance between enzymes responsible for active transport of PS from the outer to the inner leaflet (ATP11C) and those whose counteracts these activities (PLSCR1).	Phosphatidylserines	110-128	ATPase phospholipid transporting 11C	Homo sapiens	288-294
34651249-1	2022	One of the physiologic mechanisms responsible to maintain asymmetric phospholipid distribution (in particular phosphatidylserine, PS) in human erythrocyte membranes is orchestrated by the balance between enzymes responsible for active transport of PS from the outer to the inner leaflet (ATP11C) and those whose counteracts these activities (PLSCR1).	Phosphatidylserines	110-128	phospholipid scramblase 1	Homo sapiens	342-348
34699769-2	2022	However, the principal molecular partners of AnxA2 are negatively charged phospholipids such as phosphatidylserine and phosphatidyl-inositol-(4,5)-phosphate.	Phosphatidylserines	96-114	annexin A2	Homo sapiens	45-50
34752677-6	2022	RESULTS: Platelets from COVID-19 patients showed significantly higher levels of phosphorylated AKT, which was correlated with CD62p expression and phosphatidylserine (PS) externalization.	Phosphatidylserines	147-165	AKT serine/threonine kinase 1	Homo sapiens	95-98
34752677-6	2022	RESULTS: Platelets from COVID-19 patients showed significantly higher levels of phosphorylated AKT, which was correlated with CD62p expression and phosphatidylserine (PS) externalization.	Phosphatidylserines	167-169	AKT serine/threonine kinase 1	Homo sapiens	95-98
34817532-6	2022	ORP10 exhibited a lipid exchange activity toward its ligands, PI4P and phosphatidylserine (PS), between liposomes in vitro, and between the ER and endosomes in situ.	Phosphatidylserines	71-89	oxysterol binding protein like 10	Homo sapiens	0-5
34817532-6	2022	ORP10 exhibited a lipid exchange activity toward its ligands, PI4P and phosphatidylserine (PS), between liposomes in vitro, and between the ER and endosomes in situ.	Phosphatidylserines	91-93	oxysterol binding protein like 10	Homo sapiens	0-5
34817532-7	2022	Cell biological analysis demonstrated that ORP10 supplies a pool of PS from the ER, in exchange for PI4P, to endosomes where the PS-binding protein EHD1 is recruited to facilitate endosome fission.	Phosphatidylserines	68-70	oxysterol binding protein like 10	Homo sapiens	43-48
34817532-7	2022	Cell biological analysis demonstrated that ORP10 supplies a pool of PS from the ER, in exchange for PI4P, to endosomes where the PS-binding protein EHD1 is recruited to facilitate endosome fission.	Phosphatidylserines	68-70	epiregulin	Homo sapiens	80-82
34817532-7	2022	Cell biological analysis demonstrated that ORP10 supplies a pool of PS from the ER, in exchange for PI4P, to endosomes where the PS-binding protein EHD1 is recruited to facilitate endosome fission.	Phosphatidylserines	68-70	EH domain containing 1	Homo sapiens	148-152
34817532-7	2022	Cell biological analysis demonstrated that ORP10 supplies a pool of PS from the ER, in exchange for PI4P, to endosomes where the PS-binding protein EHD1 is recruited to facilitate endosome fission.	Phosphatidylserines	129-131	oxysterol binding protein like 10	Homo sapiens	43-48
34817532-7	2022	Cell biological analysis demonstrated that ORP10 supplies a pool of PS from the ER, in exchange for PI4P, to endosomes where the PS-binding protein EHD1 is recruited to facilitate endosome fission.	Phosphatidylserines	129-131	EH domain containing 1	Homo sapiens	148-152
34913345-0	2022	Enhancing the Endocytosis of Phosphatidylserine-Containing Liposomes through Tim4 by Modulation of Membrane Fluidity.	Phosphatidylserines	29-47	T cell immunoglobulin and mucin domain containing 4	Homo sapiens	77-81
34913345-1	2022	Phosphatidylserine (PS) is a unique lipid that is recognized by the endogenetic receptor, T-cell immunoglobulin mucin protein 4 (Tim4), and PS-containing liposomes have potential use in therapeutic applications.	Phosphatidylserines	0-18	T cell immunoglobulin and mucin domain containing 4	Homo sapiens	90-127
34913345-1	2022	Phosphatidylserine (PS) is a unique lipid that is recognized by the endogenetic receptor, T-cell immunoglobulin mucin protein 4 (Tim4), and PS-containing liposomes have potential use in therapeutic applications.	Phosphatidylserines	0-18	T cell immunoglobulin and mucin domain containing 4	Homo sapiens	129-133
34913345-1	2022	Phosphatidylserine (PS) is a unique lipid that is recognized by the endogenetic receptor, T-cell immunoglobulin mucin protein 4 (Tim4), and PS-containing liposomes have potential use in therapeutic applications.	Phosphatidylserines	20-22	T cell immunoglobulin and mucin domain containing 4	Homo sapiens	90-127
34913345-1	2022	Phosphatidylserine (PS) is a unique lipid that is recognized by the endogenetic receptor, T-cell immunoglobulin mucin protein 4 (Tim4), and PS-containing liposomes have potential use in therapeutic applications.	Phosphatidylserines	20-22	T cell immunoglobulin and mucin domain containing 4	Homo sapiens	129-133
34913345-2	2022	We prepared PS-containing liposomes of various lipid compositions and examined how lipid membrane fluidity affects PS recognition by Tim4 and the resulting endocytosis efficiency into Hela cells.	Phosphatidylserines	12-14	T cell immunoglobulin and mucin domain containing 4	Homo sapiens	133-137
34913345-2	2022	We prepared PS-containing liposomes of various lipid compositions and examined how lipid membrane fluidity affects PS recognition by Tim4 and the resulting endocytosis efficiency into Hela cells.	Phosphatidylserines	115-117	T cell immunoglobulin and mucin domain containing 4	Homo sapiens	133-137
34913345-6	2022	The results showed that PS recognition by Tim4 and the resulting endocytosis efficiency can be maximized by modulating the membrane fluidity of liposomes by selecting a zwitterionic helper lipid.	Phosphatidylserines	24-26	T cell immunoglobulin and mucin domain containing 4	Homo sapiens	42-46
34815099-4	2022	Gd3+ inhibits PS externalization via inhibiting the activity of scramblase, an enzyme to transfer PS to the outer leaflet of plasma membrane.	Phosphatidylserines	14-16	GRDX	Homo sapiens	0-3
34815099-4	2022	Gd3+ inhibits PS externalization via inhibiting the activity of scramblase, an enzyme to transfer PS to the outer leaflet of plasma membrane.	Phosphatidylserines	98-100	GRDX	Homo sapiens	0-3
34590635-6	2021	PS partitioning between the coexisting phases is confirmed by a fluorescent Annexin V probe.	Phosphatidylserines	0-2	annexin A5	Homo sapiens	76-85
34903667-3	2021	This anchor-binding specificity renders KRAS-PM localization and signaling capacity critically dependent on PM PtdSer content.	Phosphatidylserines	111-117	KRAS proto-oncogene, GTPase	Homo sapiens	40-44
34903667-8	2021	Taken together, these results support targeting PI4KIIIalpha in KRAS-mutant cancers to deplete the PM-to-ER PI4P gradient, reducing PM PtdSer content.	Phosphatidylserines	135-141	KRAS proto-oncogene, GTPase	Homo sapiens	64-68
34905596-6	2022	ACKR3/CXCR7-ligation did not affect surface availability of GPIbalpha, GPV, GPVI, GPIX, alphav-integrin, beta3-integrin, coagulation profile-(APTT, PT), bleeding time, plasma-dependent thrombin generation-(thrombinoscopy) or clot formation-(thromboelastography), but counteracted activation-induced phosphatidylserine exposure and procoagulant platelet-assisted thrombin generation.	Phosphatidylserines	299-317	atypical chemokine receptor 3	Homo sapiens	0-5
34905596-6	2022	ACKR3/CXCR7-ligation did not affect surface availability of GPIbalpha, GPV, GPVI, GPIX, alphav-integrin, beta3-integrin, coagulation profile-(APTT, PT), bleeding time, plasma-dependent thrombin generation-(thrombinoscopy) or clot formation-(thromboelastography), but counteracted activation-induced phosphatidylserine exposure and procoagulant platelet-assisted thrombin generation.	Phosphatidylserines	299-317	atypical chemokine receptor 3	Homo sapiens	6-11
34748127-1	2021	ANNEXIN V belongs to a family of phospholipid binding proteins which is able to bind to negatively charged phospholipids such as phosphatidylserine (PS) in the presence of a high affinity Ca2+ ion.	Phosphatidylserines	129-147	annexin A5	Homo sapiens	0-9
34748127-1	2021	ANNEXIN V belongs to a family of phospholipid binding proteins which is able to bind to negatively charged phospholipids such as phosphatidylserine (PS) in the presence of a high affinity Ca2+ ion.	Phosphatidylserines	149-151	annexin A5	Homo sapiens	0-9
34748127-2	2021	When apoptosis occurs, even at early stage, PS will be exposed to the outside of the cell surface from the cytoplasm side of membrane leaflets., Therefore ANNEXIN V has been suggested as a bio-marker for imaging early apoptotic events of various cell death including those in disease conditions.	Phosphatidylserines	44-46	annexin A5	Homo sapiens	155-164
34610453-11	2021	The cell mortality rate, cell shrinking and the phosphatidylserine (PS) ectropion (Annexin V+/PI- cells and Annexin V+/PI+ cells) of CgAIF1 transfected HEK293T cells were significantly increased, compared to the groups with or without pcDNA3.1 transfection.	Phosphatidylserines	48-66	allograft inflammatory factor 1	Crassostrea gigas	133-139
34610453-11	2021	The cell mortality rate, cell shrinking and the phosphatidylserine (PS) ectropion (Annexin V+/PI- cells and Annexin V+/PI+ cells) of CgAIF1 transfected HEK293T cells were significantly increased, compared to the groups with or without pcDNA3.1 transfection.	Phosphatidylserines	68-70	allograft inflammatory factor 1	Crassostrea gigas	133-139
34854246-8	2021	As PS+ PMPs carried programmed death-ligand 1 (PD-L1), they may affect T cell expansion or function.	Phosphatidylserines	3-5	CD274 molecule	Homo sapiens	20-45
34854246-8	2021	As PS+ PMPs carried programmed death-ligand 1 (PD-L1), they may affect T cell expansion or function.	Phosphatidylserines	3-5	CD274 molecule	Homo sapiens	47-52
33678127-11	2021	CONCLUSIONS: The results suggest that CaSR might play significant roles in the induction of nephrolithiasis in rats by regulating reactive oxygen species (ROS) and PS ectropion and the composition of urine, OPN, KIM-1, and ERK expression.	Phosphatidylserines	164-166	calcium-sensing receptor	Rattus norvegicus	38-42
34506250-6	2021	Externalization of cell membrane phosphatidylserine (PS) is crucial for enhancement of binding of H. pylori to cells by CGT and for cytotoxin-associated gene A (CagA)-induced pathogenesis.	Phosphatidylserines	33-51	S100 calcium binding protein A8	Homo sapiens	161-165
34813649-0	2021	Regulation of Tim-3 function by binding to phosphatidylserine.	Phosphatidylserines	43-61	hepatitis A virus cellular receptor 2	Homo sapiens	14-19
34884486-12	2021	Our data suggested that FLS-associated PLA1A cleaves membrane-exposed PS into lysoPS, which is subsequently converted to LPA by ATX.	Phosphatidylserines	70-72	phospholipase A1 member A	Homo sapiens	39-44
34884486-12	2021	Our data suggested that FLS-associated PLA1A cleaves membrane-exposed PS into lysoPS, which is subsequently converted to LPA by ATX.	Phosphatidylserines	70-72	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	128-131
34795295-3	2021	We observe high levels of GAPDH binding to the outer surface of EVs via a phosphatidylserine binding motif (G58), which promotes extensive EV clustering.	Phosphatidylserines	74-92	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	26-31
34115854-3	2021	In Arabidopsis, PS is relatively enriched in flower and root tissues, and the genetic disturbance of PS biosynthesis in PHOSPHATIDYLSERINE SYNTHASE1 (PSS1)/pss1 heterozygotes induces sporophytic and gametophytic defects during pollen maturation.	Phosphatidylserines	16-18	phosphatidyl serine synthase family protein	Arabidopsis thaliana	150-154
34115854-3	2021	In Arabidopsis, PS is relatively enriched in flower and root tissues, and the genetic disturbance of PS biosynthesis in PHOSPHATIDYLSERINE SYNTHASE1 (PSS1)/pss1 heterozygotes induces sporophytic and gametophytic defects during pollen maturation.	Phosphatidylserines	16-18	phosphatidyl serine synthase family protein	Arabidopsis thaliana	156-160
34115854-3	2021	In Arabidopsis, PS is relatively enriched in flower and root tissues, and the genetic disturbance of PS biosynthesis in PHOSPHATIDYLSERINE SYNTHASE1 (PSS1)/pss1 heterozygotes induces sporophytic and gametophytic defects during pollen maturation.	Phosphatidylserines	101-103	phosphatidyl serine synthase family protein	Arabidopsis thaliana	120-148
34115854-3	2021	In Arabidopsis, PS is relatively enriched in flower and root tissues, and the genetic disturbance of PS biosynthesis in PHOSPHATIDYLSERINE SYNTHASE1 (PSS1)/pss1 heterozygotes induces sporophytic and gametophytic defects during pollen maturation.	Phosphatidylserines	101-103	phosphatidyl serine synthase family protein	Arabidopsis thaliana	150-154
34115854-3	2021	In Arabidopsis, PS is relatively enriched in flower and root tissues, and the genetic disturbance of PS biosynthesis in PHOSPHATIDYLSERINE SYNTHASE1 (PSS1)/pss1 heterozygotes induces sporophytic and gametophytic defects during pollen maturation.	Phosphatidylserines	101-103	phosphatidyl serine synthase family protein	Arabidopsis thaliana	156-160
34804041-2	2021	Independent of apoptosis, PS is redistributed to the surface of CD8 T cells in response to TCR-mediated activation.	Phosphatidylserines	26-28	T cell receptor alpha variable 6-3	Mus musculus	91-94
34804041-3	2021	Annexin V (AnnV) is a protein known to bind PS with high affinity and has been effectively utilized to anchor antigen to the surface of CD8 T cells.	Phosphatidylserines	44-46	annexin A5	Mus musculus	0-9
34804041-6	2021	In vitro analysis revealed that AnnV-IL2 is able to specifically bind PS on the T cell surface following TCR stimulation.	Phosphatidylserines	70-72	interleukin 2	Mus musculus	37-40
34804041-6	2021	In vitro analysis revealed that AnnV-IL2 is able to specifically bind PS on the T cell surface following TCR stimulation.	Phosphatidylserines	70-72	T cell receptor alpha variable 6-3	Mus musculus	105-108
34805227-5	2021	The concentration of the PS-exposing EVs (PS+ EVs) from platelets (CD42a+, endothelial cells (CD62E+), and PS+ EVs expressing tissue factor (TF) and vascular cell adhesion molecule 1 (VCAM-1) were measured by flow cytometry.	Phosphatidylserines	25-27	glycoprotein IX platelet	Homo sapiens	67-72
34805227-5	2021	The concentration of the PS-exposing EVs (PS+ EVs) from platelets (CD42a+, endothelial cells (CD62E+), and PS+ EVs expressing tissue factor (TF) and vascular cell adhesion molecule 1 (VCAM-1) were measured by flow cytometry.	Phosphatidylserines	25-27	selectin E	Homo sapiens	94-99
34805227-5	2021	The concentration of the PS-exposing EVs (PS+ EVs) from platelets (CD42a+, endothelial cells (CD62E+), and PS+ EVs expressing tissue factor (TF) and vascular cell adhesion molecule 1 (VCAM-1) were measured by flow cytometry.	Phosphatidylserines	25-27	coagulation factor III, tissue factor	Homo sapiens	126-139
34805227-5	2021	The concentration of the PS-exposing EVs (PS+ EVs) from platelets (CD42a+, endothelial cells (CD62E+), and PS+ EVs expressing tissue factor (TF) and vascular cell adhesion molecule 1 (VCAM-1) were measured by flow cytometry.	Phosphatidylserines	25-27	vascular cell adhesion molecule 1	Homo sapiens	149-182
34805227-5	2021	The concentration of the PS-exposing EVs (PS+ EVs) from platelets (CD42a+, endothelial cells (CD62E+), and PS+ EVs expressing tissue factor (TF) and vascular cell adhesion molecule 1 (VCAM-1) were measured by flow cytometry.	Phosphatidylserines	25-27	vascular cell adhesion molecule 1	Homo sapiens	184-190
34585770-5	2021	Cdc50a knockdown leads to phosphatidylserine exposure at synapses and subsequent erroneous synapse removal by microglia partly via the GPR56 pathway.	Phosphatidylserines	26-44	transmembrane protein 30A	Mus musculus	0-6
34585770-5	2021	Cdc50a knockdown leads to phosphatidylserine exposure at synapses and subsequent erroneous synapse removal by microglia partly via the GPR56 pathway.	Phosphatidylserines	26-44	adhesion G protein-coupled receptor G1	Mus musculus	135-140
34727930-4	2021	METHODS: Lipid overlay assays and Phosphatidylserine (PS)-pull down assays confirmed the binding of DLC1-START to PS.	Phosphatidylserines	34-52	DLC1 Rho GTPase activating protein	Homo sapiens	100-104
34727930-4	2021	METHODS: Lipid overlay assays and Phosphatidylserine (PS)-pull down assays confirmed the binding of DLC1-START to PS.	Phosphatidylserines	54-56	DLC1 Rho GTPase activating protein	Homo sapiens	100-104
34727930-5	2021	Co-immunoprecipitation studies demonstrated the interaction between DLC1-START and Phospholipase C delta 1 (PLCD1) or Caveolin-1, and the contribution of PS to those interactions.	Phosphatidylserines	154-156	DLC1 Rho GTPase activating protein	Homo sapiens	68-72
34727930-9	2021	RESULTS: We identified PS as the lipid ligand for DLC1-START and determined that DLC1-START also binds PLCD1 protein in addition to Caveolin-1.	Phosphatidylserines	23-25	DLC1 Rho GTPase activating protein	Homo sapiens	50-54
34727930-9	2021	RESULTS: We identified PS as the lipid ligand for DLC1-START and determined that DLC1-START also binds PLCD1 protein in addition to Caveolin-1.	Phosphatidylserines	23-25	DLC1 Rho GTPase activating protein	Homo sapiens	81-85
34727930-9	2021	RESULTS: We identified PS as the lipid ligand for DLC1-START and determined that DLC1-START also binds PLCD1 protein in addition to Caveolin-1.	Phosphatidylserines	23-25	phospholipase C delta 1	Homo sapiens	103-108
34727930-10	2021	PS binding contributes to the interaction of DLC1 with Caveolin-1 and with PLCD1.	Phosphatidylserines	0-2	DLC1 Rho GTPase activating protein	Homo sapiens	45-49
34727930-10	2021	PS binding contributes to the interaction of DLC1 with Caveolin-1 and with PLCD1.	Phosphatidylserines	0-2	caveolin 1	Homo sapiens	55-65
34727930-10	2021	PS binding contributes to the interaction of DLC1 with Caveolin-1 and with PLCD1.	Phosphatidylserines	0-2	phospholipase C delta 1	Homo sapiens	75-80
34727930-15	2021	They also expand the versatility of START domains, as DLC1-START is the first found to bind PS, which promotes the binding to other proteins.	Phosphatidylserines	92-94	DLC1 Rho GTPase activating protein	Homo sapiens	54-58
34520855-3	2021	Phosphatidylserine exposed on the surface of activated platelets is a ligand for LOX-1.	Phosphatidylserines	0-18	oxidized low density lipoprotein receptor 1	Rattus norvegicus	81-86
34727579-6	2021	We also report that upon an inflammatory stimulus, cerebellar levels of ABHD12 increase to possibly metabolize the heightened oxidized PS levels, temper phagocytosis and in turn control neuroinflammation during oxidative stress.	Phosphatidylserines	135-137	abhydrolase domain containing 12	Mus musculus	72-78
34473881-5	2021	PS exposure was estimated from annexin-V-binding, cell volume from forward scatter (FSC) and GSH from CMFDA fluorescence by flow cytometry.	Phosphatidylserines	0-2	annexin A5	Homo sapiens	31-40
34516042-6	2021	This localization of the functional amino acid residues suggests that PSS1 is regulated by inhibition with PS in the cytoplasmic leaflet of the ER membrane and synthesizes PS at the luminal leaflet.	Phosphatidylserines	107-109	phosphatidylserine synthase 1	Homo sapiens	70-74
34516042-6	2021	This localization of the functional amino acid residues suggests that PSS1 is regulated by inhibition with PS in the cytoplasmic leaflet of the ER membrane and synthesizes PS at the luminal leaflet.	Phosphatidylserines	172-174	phosphatidylserine synthase 1	Homo sapiens	70-74
34478523-0	2021	A novel mechanism of thrombocytopenia by PS exposure through TMEM16F in sphingomyelin synthase 1 deficiency.	Phosphatidylserines	41-43	anoctamin 6	Mus musculus	61-68
34478523-4	2021	Deficiency of SMS1, but not SMS2, prevented SM production and enhanced phosphatidylserine (PS) externalization on the plasma membranes of platelets and megakaryocytes.	Phosphatidylserines	71-89	sphingomyelin synthase 1	Mus musculus	14-18
34478523-4	2021	Deficiency of SMS1, but not SMS2, prevented SM production and enhanced phosphatidylserine (PS) externalization on the plasma membranes of platelets and megakaryocytes.	Phosphatidylserines	91-93	sphingomyelin synthase 1	Mus musculus	14-18
34478523-8	2021	SMS1-KO tMEFs in which TMEM16F was knocked out using the CRISPR-Cas9 system lacked both the Ca2+ influx and excess PS exposure seen in SMS1-KO tMEFs.	Phosphatidylserines	115-117	sphingomyelin synthase 1	Mus musculus	0-4
34478523-8	2021	SMS1-KO tMEFs in which TMEM16F was knocked out using the CRISPR-Cas9 system lacked both the Ca2+ influx and excess PS exposure seen in SMS1-KO tMEFs.	Phosphatidylserines	115-117	anoctamin 6	Mus musculus	23-30
34478523-9	2021	Therefore, SM depletion on platelet membrane microdomains due to SMS1 deficiency enhanced PS externalization via a Ca2+ influx through TMEM16F activation, leading to elevated platelet clearance and causing hemostasis dysfunction through thrombocytopenia.	Phosphatidylserines	90-92	sphingomyelin synthase 1	Mus musculus	65-69
34478523-9	2021	Therefore, SM depletion on platelet membrane microdomains due to SMS1 deficiency enhanced PS externalization via a Ca2+ influx through TMEM16F activation, leading to elevated platelet clearance and causing hemostasis dysfunction through thrombocytopenia.	Phosphatidylserines	90-92	anoctamin 6	Mus musculus	135-142
34831089-5	2021	Thus lipopolysaccharide (LPS) induced microglial exosomes to contain more inflammatory signals, whilst stimulation with the TREM2 ligand phosphatidylserine (PS+) increased metabolic signals within the microglial exosomes.	Phosphatidylserines	137-155	triggering receptor expressed on myeloid cells 2	Homo sapiens	124-129
34528675-1	2021	ATP11C, a member of the P4-ATPase family, translocates phosphatidylserine and phosphatidylethanolamine at the plasma membrane.	Phosphatidylserines	55-73	ATPase phospholipid transporting 11C	Homo sapiens	0-6
34712698-0	2021	Osh6 Revisited: Control of PS Transport by the Concerted Actions of PI4P and Sac1 Phosphatase.	Phosphatidylserines	27-29	SAC1 like phosphatidylinositide phosphatase	Homo sapiens	77-81
34712698-9	2021	Our results also highlighted the importance of the ER resident Sac1 phosphatase that enables the PS transport and ensures its directionality by PI4P consumption.	Phosphatidylserines	97-99	SAC1 like phosphatidylinositide phosphatase	Homo sapiens	63-67
34712698-10	2021	Furthermore, we showed that the Sac1 activity is regulated by the negative charge of the membrane that can be provided by PS or PI anions in the case of the ER membrane.	Phosphatidylserines	122-124	SAC1 like phosphatidylinositide phosphatase	Homo sapiens	32-36
34685684-6	2021	In addition, the depletion of Mertk, which indirectly senses phosphatidylserine on apoptotic cells, reduced the phosphorylation levels of PLCgamma1 and IP3R, resulting in attenuation of the Orai1-STIM1 interaction and inefficient SOCE upon apoptotic cell stimulation.	Phosphatidylserines	61-79	MER proto-oncogene, tyrosine kinase	Homo sapiens	30-35
34685684-6	2021	In addition, the depletion of Mertk, which indirectly senses phosphatidylserine on apoptotic cells, reduced the phosphorylation levels of PLCgamma1 and IP3R, resulting in attenuation of the Orai1-STIM1 interaction and inefficient SOCE upon apoptotic cell stimulation.	Phosphatidylserines	61-79	phospholipase C gamma 1	Homo sapiens	138-147
34685684-6	2021	In addition, the depletion of Mertk, which indirectly senses phosphatidylserine on apoptotic cells, reduced the phosphorylation levels of PLCgamma1 and IP3R, resulting in attenuation of the Orai1-STIM1 interaction and inefficient SOCE upon apoptotic cell stimulation.	Phosphatidylserines	61-79	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	152-156
34685684-6	2021	In addition, the depletion of Mertk, which indirectly senses phosphatidylserine on apoptotic cells, reduced the phosphorylation levels of PLCgamma1 and IP3R, resulting in attenuation of the Orai1-STIM1 interaction and inefficient SOCE upon apoptotic cell stimulation.	Phosphatidylserines	61-79	ORAI calcium release-activated calcium modulator 1	Homo sapiens	190-195
34685684-6	2021	In addition, the depletion of Mertk, which indirectly senses phosphatidylserine on apoptotic cells, reduced the phosphorylation levels of PLCgamma1 and IP3R, resulting in attenuation of the Orai1-STIM1 interaction and inefficient SOCE upon apoptotic cell stimulation.	Phosphatidylserines	61-79	stromal interaction molecule 1	Homo sapiens	196-201
34620987-6	2021	Enpp4 is a membrane protein that binds, without hydrolyzing, phosphatidylserine and its effects are mediated by the receptor s1pr5, although not via the generation of S1P.	Phosphatidylserines	61-79	ectonucleotide pyrophosphatase/phosphodiesterase 4 L homeolog	Xenopus laevis	0-5
34405304-0	2021	Long-circulating XTEN864-annexin A5 fusion protein for phosphatidylserine-related therapeutic applications.	Phosphatidylserines	55-73	annexin A5	Mus musculus	25-35
34216604-4	2021	We report that LPA 16:0, 18:0 and 18:1, but not LPA 20:4, induced PS exposure and the release of small PS- and large PS+ REVs through LPA3 receptor signalling in RBCs.	Phosphatidylserines	66-68	lysophosphatidic acid receptor 3	Homo sapiens	134-138
34216604-4	2021	We report that LPA 16:0, 18:0 and 18:1, but not LPA 20:4, induced PS exposure and the release of small PS- and large PS+ REVs through LPA3 receptor signalling in RBCs.	Phosphatidylserines	103-105	lysophosphatidic acid receptor 3	Homo sapiens	134-138
34216604-4	2021	We report that LPA 16:0, 18:0 and 18:1, but not LPA 20:4, induced PS exposure and the release of small PS- and large PS+ REVs through LPA3 receptor signalling in RBCs.	Phosphatidylserines	117-120	lysophosphatidic acid receptor 3	Homo sapiens	134-138
34216604-8	2021	Furthermore, LPA receptor agonists and antagonists highlighted that LPA 20:4 inhibited LPA3-dependent PS exposure and, through the LPA2 receptor, inhibited PS- REV production.	Phosphatidylserines	102-104	lysophosphatidic acid receptor 3	Homo sapiens	87-91
34174696-5	2021	CD300a or CD300f binding to externalized phosphatidylserine or extracellular ceramides, respectively, inhibits FcepsilonRI-mediated mast cell activation.	Phosphatidylserines	41-59	CD300a molecule	Homo sapiens	0-6
34174696-5	2021	CD300a or CD300f binding to externalized phosphatidylserine or extracellular ceramides, respectively, inhibits FcepsilonRI-mediated mast cell activation.	Phosphatidylserines	41-59	CD300 molecule like family member f	Homo sapiens	10-16
34579880-7	2021	Western blots revealed a substantial reduction of alpha-Syn and phosphorylated tau protein in the anti-oxidative pathway through interaction with PS.	Phosphatidylserines	146-148	synuclein alpha	Homo sapiens	50-59
34579880-7	2021	Western blots revealed a substantial reduction of alpha-Syn and phosphorylated tau protein in the anti-oxidative pathway through interaction with PS.	Phosphatidylserines	146-148	microtubule associated protein tau	Homo sapiens	79-82
34319156-7	2021	We found that rVSV/G and rVSV/EBOV-GP virions produced in XKR8 knockout cells contain decreased levels of PS on their surfaces, and the PS-deficient rVSV/EBOV-GP virions are 70% less efficient at infecting cells through PS receptors.	Phosphatidylserines	106-108	XK related 8	Homo sapiens	58-62
34319156-11	2021	This suggests that XKR8, in addition to mediating virion PS levels, may also be critical for enveloped virus budding at the plasma membrane.	Phosphatidylserines	57-59	XK related 8	Homo sapiens	19-23
34384763-4	2021	Our results show that KRAS4B approximates an entropic ensemble of configurations at model membranes containing 30% phosphatidylserine lipids, which is not significantly shaped by interactions between the globular G-domain of KRAS4B and the lipid membrane.	Phosphatidylserines	115-133	KRAS proto-oncogene, GTPase	Homo sapiens	22-28
34435619-5	2021	Here, we show that TIM-3 promotes NF-kB signaling and IL-2 secretion following T cell receptor stimulation in Jurkat cells, and that this activity is regulated by binding to phosphatidylserine (PS).	Phosphatidylserines	174-192	hepatitis A virus cellular receptor 2	Homo sapiens	19-24
34435619-5	2021	Here, we show that TIM-3 promotes NF-kB signaling and IL-2 secretion following T cell receptor stimulation in Jurkat cells, and that this activity is regulated by binding to phosphatidylserine (PS).	Phosphatidylserines	174-192	interleukin 2	Homo sapiens	54-58
34435619-5	2021	Here, we show that TIM-3 promotes NF-kB signaling and IL-2 secretion following T cell receptor stimulation in Jurkat cells, and that this activity is regulated by binding to phosphatidylserine (PS).	Phosphatidylserines	194-196	hepatitis A virus cellular receptor 2	Homo sapiens	19-24
34435619-5	2021	Here, we show that TIM-3 promotes NF-kB signaling and IL-2 secretion following T cell receptor stimulation in Jurkat cells, and that this activity is regulated by binding to phosphatidylserine (PS).	Phosphatidylserines	194-196	interleukin 2	Homo sapiens	54-58
34435619-6	2021	TIM-3 signaling is stimulated by PS exposed constitutively in cultured Jurkat cells, and can be blocked by mutating the PS-binding site or by occluding this site with an antibody.	Phosphatidylserines	33-35	hepatitis A virus cellular receptor 2	Homo sapiens	0-5
34435619-6	2021	TIM-3 signaling is stimulated by PS exposed constitutively in cultured Jurkat cells, and can be blocked by mutating the PS-binding site or by occluding this site with an antibody.	Phosphatidylserines	120-122	hepatitis A virus cellular receptor 2	Homo sapiens	0-5
34403372-1	2021	ATP11A translocates phosphatidylserine (PtdSer), but not phosphatidylcholine (PtdCho), from the outer to inner leaflet of plasma membranes, thereby maintaining the asymmetric distribution of PtdSer.	Phosphatidylserines	20-38	ATPase, class VI, type 11A	Mus musculus	0-6
34403372-1	2021	ATP11A translocates phosphatidylserine (PtdSer), but not phosphatidylcholine (PtdCho), from the outer to inner leaflet of plasma membranes, thereby maintaining the asymmetric distribution of PtdSer.	Phosphatidylserines	40-46	ATPase, class VI, type 11A	Mus musculus	0-6
34403372-1	2021	ATP11A translocates phosphatidylserine (PtdSer), but not phosphatidylcholine (PtdCho), from the outer to inner leaflet of plasma membranes, thereby maintaining the asymmetric distribution of PtdSer.	Phosphatidylserines	191-197	ATPase, class VI, type 11A	Mus musculus	0-6
34259806-4	2021	This interaction is required for phosphatidylethanolamine (PE) production by the PS decarboxylase Psd2, whereby PS transported from the ER to the PM by Osh6/7 is endocytosed to the site of Psd2 in endosomes/Golgi/vacuoles.	Phosphatidylserines	112-114	phosphatidylserine decarboxylase 2	Saccharomyces cerevisiae S288C	98-102
34259806-4	2021	This interaction is required for phosphatidylethanolamine (PE) production by the PS decarboxylase Psd2, whereby PS transported from the ER to the PM by Osh6/7 is endocytosed to the site of Psd2 in endosomes/Golgi/vacuoles.	Phosphatidylserines	112-114	oxysterol-binding protein OSH6	Saccharomyces cerevisiae S288C	152-158
34259806-4	2021	This interaction is required for phosphatidylethanolamine (PE) production by the PS decarboxylase Psd2, whereby PS transported from the ER to the PM by Osh6/7 is endocytosed to the site of Psd2 in endosomes/Golgi/vacuoles.	Phosphatidylserines	112-114	phosphatidylserine decarboxylase 2	Saccharomyces cerevisiae S288C	189-193
34259806-5	2021	This role for Ist2 and Osh6/7 in nonvesicular PS transport is specific, as other tethers/transport proteins do not compensate.	Phosphatidylserines	46-48	Ist2p	Saccharomyces cerevisiae S288C	14-18
34259806-5	2021	This role for Ist2 and Osh6/7 in nonvesicular PS transport is specific, as other tethers/transport proteins do not compensate.	Phosphatidylserines	46-48	oxysterol-binding protein OSH6	Saccharomyces cerevisiae S288C	23-29
34480042-4	2021	PS exposure in procoagulant platelets requires TMEM16F, a phospholipid scramblase.	Phosphatidylserines	0-2	anoctamin 6	Homo sapiens	47-54
34251968-0	2021	A new flavor of cellular Atg8-family protein lipidation - alternative conjugation to phosphatidylserine during CASM.	Phosphatidylserines	85-103	GABA type A receptor associated protein like 1	Homo sapiens	25-29
34288243-7	2021	By large-scale sequencing we identified a novel recessive BD risk gene, SERINC2, which plays a role in synthesis of sphingolipid and phosphatidylserine (PS).	Phosphatidylserines	133-151	serine incorporator 2	Homo sapiens	72-79
34288243-7	2021	By large-scale sequencing we identified a novel recessive BD risk gene, SERINC2, which plays a role in synthesis of sphingolipid and phosphatidylserine (PS).	Phosphatidylserines	153-155	serine incorporator 2	Homo sapiens	72-79
34268737-2	2021	CD300a is an inhibitory receptor which binds phosphatidylserine (PS) and phosphatidylethanolamine (PE), presented on the membranes of apoptotic cells.	Phosphatidylserines	45-63	CD300A molecule	Mus musculus	0-6
34268737-2	2021	CD300a is an inhibitory receptor which binds phosphatidylserine (PS) and phosphatidylethanolamine (PE), presented on the membranes of apoptotic cells.	Phosphatidylserines	65-67	CD300A molecule	Mus musculus	0-6
34268737-3	2021	CD300a binding to PS and PE, also known as the "eat me" signal, mediates immune tolerance to dying cells.	Phosphatidylserines	18-20	CD300A molecule	Mus musculus	0-6
34390515-0	2021	Hyperuricemia enhances procoagulant activity of vascular endothelial cells through TMEM16F regulated phosphatidylserine exposure and microparticle release.	Phosphatidylserines	101-119	anoctamin 6	Rattus norvegicus	83-90
34390515-8	2021	Importantly, we found that TMEM16F expression is significantly upregulated in UA-treated EC, which is crucial for UA-induced PS exposure and MP formation.	Phosphatidylserines	125-127	anoctamin 6	Rattus norvegicus	27-34
34390515-11	2021	Our results demonstrate a thrombotic role of EC in hyperuricemia through TMEM16F-mediated PS exposure and MPs release.	Phosphatidylserines	90-92	anoctamin 6	Rattus norvegicus	73-80
34490332-4	2021	The milk fat globule membrane contains large proportions of sphingomyelin (SM), phosphatidylcholine (PC), and phosphatidylethanolamine (PE), and some phosphatidylserine (PS), phosphatidylinositol (PI), and glycosphingolipids.	Phosphatidylserines	170-172	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	4-29
34358376-7	2022	Annexin V binding to externalized phosphatidylserine and analysis of mitochondrial potential allowed the assessment of apoptosis.	Phosphatidylserines	34-52	annexin A5	Homo sapiens	0-9
34348736-5	2021	While ROS generation was not observed following the exposure to TiO2 NPs, intracellular calcium increased and caspase-3 was activated, which up-regulated scramblase activity, leading to PS exposure.	Phosphatidylserines	186-188	caspase 3	Rattus norvegicus	110-119
34074213-3	2021	A lipids distribution screen suggested TMEM41B and VMP1 are critical to the normal distribution of cholesterol and phosphatidylserine.	Phosphatidylserines	115-133	transmembrane protein 41B	Homo sapiens	39-46
34074213-3	2021	A lipids distribution screen suggested TMEM41B and VMP1 are critical to the normal distribution of cholesterol and phosphatidylserine.	Phosphatidylserines	115-133	vacuole membrane protein 1	Homo sapiens	51-55
34233115-1	2021	Three human G protein-coupled receptors (GPCRs)-GPR34/LPS1, P2Y10/LPS2, and GPR174/LPS3-are activated specifically by lysophosphatidylserine (LysoPS), an endogenous hydrolysis product of a cell membrane component, phosphatidylserine (PS).	Phosphatidylserines	214-232	G protein-coupled receptor 34	Homo sapiens	48-53
34233115-1	2021	Three human G protein-coupled receptors (GPCRs)-GPR34/LPS1, P2Y10/LPS2, and GPR174/LPS3-are activated specifically by lysophosphatidylserine (LysoPS), an endogenous hydrolysis product of a cell membrane component, phosphatidylserine (PS).	Phosphatidylserines	214-232	P2Y receptor family member 10	Homo sapiens	60-65
34233115-1	2021	Three human G protein-coupled receptors (GPCRs)-GPR34/LPS1, P2Y10/LPS2, and GPR174/LPS3-are activated specifically by lysophosphatidylserine (LysoPS), an endogenous hydrolysis product of a cell membrane component, phosphatidylserine (PS).	Phosphatidylserines	214-232	G protein-coupled receptor 174	Homo sapiens	76-82
34233115-1	2021	Three human G protein-coupled receptors (GPCRs)-GPR34/LPS1, P2Y10/LPS2, and GPR174/LPS3-are activated specifically by lysophosphatidylserine (LysoPS), an endogenous hydrolysis product of a cell membrane component, phosphatidylserine (PS).	Phosphatidylserines	234-236	G protein-coupled receptor 34	Homo sapiens	48-53
34233115-1	2021	Three human G protein-coupled receptors (GPCRs)-GPR34/LPS1, P2Y10/LPS2, and GPR174/LPS3-are activated specifically by lysophosphatidylserine (LysoPS), an endogenous hydrolysis product of a cell membrane component, phosphatidylserine (PS).	Phosphatidylserines	234-236	P2Y receptor family member 10	Homo sapiens	60-65
34233115-1	2021	Three human G protein-coupled receptors (GPCRs)-GPR34/LPS1, P2Y10/LPS2, and GPR174/LPS3-are activated specifically by lysophosphatidylserine (LysoPS), an endogenous hydrolysis product of a cell membrane component, phosphatidylserine (PS).	Phosphatidylserines	234-236	G protein-coupled receptor 174	Homo sapiens	76-82
34359995-8	2021	We show that point mutations in the phosphatidylserine binding site of TIM-1 lead to reduced cell binding, entry, and infection of CHIKV.	Phosphatidylserines	36-54	hepatitis A virus cellular receptor 1	Homo sapiens	71-76
34215655-5	2021	This inhibitory effect on anti-CD3/28 activated T cells was observed on both CD4+ and CD8+ cells and independently of monocytes, suggesting the effects of 11.31 were directly mediated by binding to externalized PS on activated T cells.	Phosphatidylserines	211-213	sialic acid binding Ig like lectin 7	Homo sapiens	31-37
34215655-7	2021	Collectively, our findings indicate that PS-targeting mAb 11.31 suppresses cytokine production by anti-CD3/28 activated T cells.	Phosphatidylserines	41-43	sialic acid binding Ig like lectin 7	Homo sapiens	103-109
34262012-13	2021	These results revealed that DMSCs alone in the therapeutic stem cell preparation or the apoptotic cells induced in vivo may exert the same immunomodulatory property as the "living MSCs preparation" through releasing PS, which was further recognized by MerTK and participated in modulating immune cells.	Phosphatidylserines	216-218	MER proto-oncogene, tyrosine kinase	Homo sapiens	252-257
34166709-3	2021	PLA1A specifically hydrolyzes sn-1 fatty acid of phosphatidylserine (PS) or 1-acyl-lysophosphatidylserine (1-acyl-lysoPS).	Phosphatidylserines	49-67	phospholipase A1 member A	Homo sapiens	0-5
34166709-3	2021	PLA1A specifically hydrolyzes sn-1 fatty acid of phosphatidylserine (PS) or 1-acyl-lysophosphatidylserine (1-acyl-lysoPS).	Phosphatidylserines	69-71	phospholipase A1 member A	Homo sapiens	0-5
34166709-4	2021	PS externalized by activated cells, at the surface of apoptotic cells and of extracellular vesicles is a potential source of substrate for the production of unsaturated lysoPS species by PLA1A.	Phosphatidylserines	0-2	phospholipase A1 member A	Homo sapiens	187-192
34242725-3	2021	Epidermal growth factor receptor (EGFR) is one of the most extensively studied receptors exhibiting various lipid interactions, including interactions with phosphatidylcholine, phosphatidylserine, phosphatidylinositol phosphate, cholesterol, gangliosides, and palmitate.	Phosphatidylserines	177-195	epidermal growth factor receptor	Homo sapiens	0-32
34242725-3	2021	Epidermal growth factor receptor (EGFR) is one of the most extensively studied receptors exhibiting various lipid interactions, including interactions with phosphatidylcholine, phosphatidylserine, phosphatidylinositol phosphate, cholesterol, gangliosides, and palmitate.	Phosphatidylserines	177-195	epidermal growth factor receptor	Homo sapiens	34-38
34188113-4	2021	We developed an ELISA system using a high-affinity phosphatidylserine-binder TIM4 to capture EVs and screened a 1567-compound library.	Phosphatidylserines	51-69	T cell immunoglobulin and mucin domain containing 4	Homo sapiens	77-81
34131110-4	2021	Annexin A5 (ANXA5) with high affinity for PS has a good targeting to the colon and effectively alleviates experimental colitis.	Phosphatidylserines	42-44	annexin A5	Homo sapiens	0-10
34131110-4	2021	Annexin A5 (ANXA5) with high affinity for PS has a good targeting to the colon and effectively alleviates experimental colitis.	Phosphatidylserines	42-44	annexin A5	Homo sapiens	12-17
34131110-5	2021	In contrast, ANXA5 mutant (A5m) lacking the PS-binding ability, has no accumulation in the colon and no therapeutic effects on colitis.	Phosphatidylserines	44-46	annexin A5	Homo sapiens	13-18
34131110-6	2021	Mechanistic investigations indicate that ANXA5 reduces the inflammatory cell infiltration by inhibiting endothelial cell activation dependent on PS-binding ability.	Phosphatidylserines	145-147	annexin A5	Homo sapiens	41-46
34131110-7	2021	With the increasing of PS exposure on activated HUVECs (human umbilical vein endothelial cells), ANXA5 binding induces the internalization of TLR4 via PS-dependent endocytosis.	Phosphatidylserines	23-25	annexin A5	Homo sapiens	97-102
34131110-9	2021	Our data suggest that PS-externalization is a potential target of ANXA5 aiming at targeted drug delivery (TDD) for IBD treatment.	Phosphatidylserines	22-24	annexin A5	Homo sapiens	66-71
34086889-8	2022	We further demonstrated enhanced activities of phospholipase-A1/2 in the culture supernatant of Flp-InTRex293 cells that expressed the GPR34 Q340X mutant, and their potential to catalyze the synthesis of lysophosphatidylserine from phosphatidylserine.	Phosphatidylserines	232-250	lipase H	Homo sapiens	47-65
34086889-8	2022	We further demonstrated enhanced activities of phospholipase-A1/2 in the culture supernatant of Flp-InTRex293 cells that expressed the GPR34 Q340X mutant, and their potential to catalyze the synthesis of lysophosphatidylserine from phosphatidylserine.	Phosphatidylserines	232-250	G protein-coupled receptor 34	Homo sapiens	135-140
34086889-10	2022	Our findings advocate a model of paracrine stimulation of malignant B-cells via GPR34, in which PLA is released by LELs, and hydrolyzes the phosphatidylserine exposed on apoptotic cells, generating lysophosphatidylserine, the ligand for GPR34.	Phosphatidylserines	140-158	G protein-coupled receptor 34	Homo sapiens	80-85
34086889-10	2022	Our findings advocate a model of paracrine stimulation of malignant B-cells via GPR34, in which PLA is released by LELs, and hydrolyzes the phosphatidylserine exposed on apoptotic cells, generating lysophosphatidylserine, the ligand for GPR34.	Phosphatidylserines	140-158	G protein-coupled receptor 34	Homo sapiens	237-242
34073384-3	2021	Annexin A5 (AnxA5) binds to phosphatidylserine, affecting membrane dynamics.	Phosphatidylserines	28-46	annexin A5	Homo sapiens	0-10
34073384-3	2021	Annexin A5 (AnxA5) binds to phosphatidylserine, affecting membrane dynamics.	Phosphatidylserines	28-46	annexin A5	Homo sapiens	12-17
34073384-6	2021	EVs from HeLa cells incubated with RAW264.7 cells induced phosphatidylserine exposure on the cells, suggesting a mechanism by which anxA5-coated EVs can bind to phagocytes before uptake.	Phosphatidylserines	58-76	annexin A5	Mus musculus	132-137
35348973-8	2022	Interestingly, the comprehensive analysis of transcriptomics and metabolomics indicated that Asiatic acid inhibited the gene expression of Gpat3 and thereby affected the biosynthesis of the metabolites (1-acyl-Sn-glycerol-3-phosphocholine, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine), regulating the glycerophospholipid metabolism pathway and ultimately ameliorating hepatocyte damage.	Phosphatidylserines	291-309	glycerol-3-phosphate acyltransferase 3	Rattus norvegicus	139-144
35536318-8	2022	VMP1 was shown to regulate cross-membrane phosphatidylserine (PS) distribution.	Phosphatidylserines	42-60	vacuole membrane protein 1	Homo sapiens	0-4
35536318-8	2022	VMP1 was shown to regulate cross-membrane phosphatidylserine (PS) distribution.	Phosphatidylserines	62-64	vacuole membrane protein 1	Homo sapiens	0-4
35536318-9	2022	Inhibiting PS synthesis partially rescues the DMV defects in VMP1 KO cells, suggesting that PS participates in DMV formation.	Phosphatidylserines	92-94	vacuole membrane protein 1	Homo sapiens	61-65
35257985-7	2022	An increase in the band intensity of phospholipids, increased distribution of lipid and change in membrane potential was noted in UA treated cells, which was confirmed by externalization of phosphatidylserine to the outer membrane by annexin V-FITC/PI assay.	Phosphatidylserines	190-208	annexin A5	Homo sapiens	234-243
35358472-2	2022	Several studies have reported that phosphatidylserine specific-phospholipase A1 (PLA1A) might be involved in the pathogenesis of cancers.	Phosphatidylserines	35-53	phospholipase A1 member A	Homo sapiens	81-86
35510803-0	2022	The Degree of Unsaturation of Fatty Acids in Phosphatidylserine Alters the Rate of Insulin Aggregation and the Structure and Toxicity of Amyloid Aggregates.	Phosphatidylserines	45-63	insulin	Homo sapiens	83-90
35510803-3	2022	In this work, we examine the effect of both saturated PS (DMPS) and unsaturated PS (DOPS and POPS) on the aggregation properties of insulin, as well as the structure and toxicity of insulin aggregates formed in the presence of these phospholipids.	Phosphatidylserines	80-82	insulin	Homo sapiens	132-139
35623602-4	2022	OSBP was inhibited for 24 h with 25 nM Schweinfurthin G (SWG) or Orsaponin (OSW-1), followed by analyses of cellular cholesterol, 27-hydroxy-cholesterol, and triacylglycerol concentration, phosphatidylserine synthesis rate, the lipidome, as well as lipid droplet staining and western analysis of OSBP protein.	Phosphatidylserines	189-207	oxysterol binding protein	Homo sapiens	0-4
35623558-3	2022	Here, we have studied the P. falciparum enzyme responsible for PS synthesis, Phosphatidylserine synthase (PfPSS), GFP targeting approach confirmed it to be localized in the parasite ER as well as in ER-protrusions.	Phosphatidylserines	63-65	epiregulin	Homo sapiens	182-184
35567997-0	2022	TMEM16F mediated phosphatidylserine exposure and microparticle release on erythrocyte contribute to hypercoagulable state in hyperuricemia.	Phosphatidylserines	17-35	anoctamin 6	Homo sapiens	0-7
35567997-10	2022	Collectively, these results suggest that Ca2+-dependent TMEM16F activation may be responsible for UA-induced PS exposure and MPs release of RBC, which thereby contribute to the prothrombotic risk in HUA.	Phosphatidylserines	109-111	anoctamin 6	Homo sapiens	56-63
35416331-10	2022	We concluded that the incorporation of PS into rHDLs enhanced their anti-inflammatory activity by modulating Akt1/2/3- and p38 MAPK-mediated signaling through SR-BI in stimulated macrophages.	Phosphatidylserines	39-41	thymoma viral proto-oncogene 1	Mus musculus	109-117
35416331-10	2022	We concluded that the incorporation of PS into rHDLs enhanced their anti-inflammatory activity by modulating Akt1/2/3- and p38 MAPK-mediated signaling through SR-BI in stimulated macrophages.	Phosphatidylserines	39-41	mitogen-activated protein kinase 14	Mus musculus	123-131
35416331-10	2022	We concluded that the incorporation of PS into rHDLs enhanced their anti-inflammatory activity by modulating Akt1/2/3- and p38 MAPK-mediated signaling through SR-BI in stimulated macrophages.	Phosphatidylserines	39-41	scavenger receptor class B, member 1	Mus musculus	159-164
35477179-4	2022	Venetoclax, a B-cell lymphoma 2 (BCL-2) inhibitor for B-cell malignancy, induces phosphatidylserine (PS) extracellular exposure, representing an "eat-me" signal for macrophages.	Phosphatidylserines	81-99	BCL2 apoptosis regulator	Homo sapiens	14-31
35477179-4	2022	Venetoclax, a B-cell lymphoma 2 (BCL-2) inhibitor for B-cell malignancy, induces phosphatidylserine (PS) extracellular exposure, representing an "eat-me" signal for macrophages.	Phosphatidylserines	81-99	BCL2 apoptosis regulator	Homo sapiens	33-38
35477179-4	2022	Venetoclax, a B-cell lymphoma 2 (BCL-2) inhibitor for B-cell malignancy, induces phosphatidylserine (PS) extracellular exposure, representing an "eat-me" signal for macrophages.	Phosphatidylserines	101-103	BCL2 apoptosis regulator	Homo sapiens	14-31
35477179-4	2022	Venetoclax, a B-cell lymphoma 2 (BCL-2) inhibitor for B-cell malignancy, induces phosphatidylserine (PS) extracellular exposure, representing an "eat-me" signal for macrophages.	Phosphatidylserines	101-103	BCL2 apoptosis regulator	Homo sapiens	33-38
35421309-0	2022	Cupric Ions Selectively Modulate TRAAK-Phosphatidylserine Interactions.	Phosphatidylserines	39-57	potassium two pore domain channel subfamily K member 4	Homo sapiens	33-38
35421309-4	2022	Here, we discover cupric ions selectively modulate the binding of phosphatidylserine (PS) to TRAAK but not TREK2.	Phosphatidylserines	66-84	potassium two pore domain channel subfamily K member 4	Homo sapiens	93-98
35421309-4	2022	Here, we discover cupric ions selectively modulate the binding of phosphatidylserine (PS) to TRAAK but not TREK2.	Phosphatidylserines	86-88	potassium two pore domain channel subfamily K member 4	Homo sapiens	93-98
35518199-0	2022	The involvement of oxysterol-binding protein related protein (ORP) 6 in the counter-transport of phosphatidylinositol-4-phosphate (PI4P) and phosphatidylserine (PS) in neurons.	Phosphatidylserines	141-159	oxysterol binding protein-like 6	Mus musculus	19-68
35518199-0	2022	The involvement of oxysterol-binding protein related protein (ORP) 6 in the counter-transport of phosphatidylinositol-4-phosphate (PI4P) and phosphatidylserine (PS) in neurons.	Phosphatidylserines	161-163	oxysterol binding protein-like 6	Mus musculus	19-68
35518199-8	2022	These data collectively suggest the involvement of ORP6 in the counter-transport of PI4P and PS.	Phosphatidylserines	93-95	oxysterol binding protein-like 6	Mus musculus	51-55
35425959-4	2022	Ptdss1-deficient tumor cells exposed less PS during apoptosis, which was recognized by the PS receptor MERTK.	Phosphatidylserines	42-44	phosphatidylserine synthase 1	Mus musculus	0-6
35425959-4	2022	Ptdss1-deficient tumor cells exposed less PS during apoptosis, which was recognized by the PS receptor MERTK.	Phosphatidylserines	42-44	MER proto-oncogene tyrosine kinase	Mus musculus	103-108
35458682-5	2022	Some extracellular PLA1s exhibit PLA1 activities specific to phosphatidic acid (PA) or phosphatidylserine (PS) and serve to produce lysophospholipid mediators such as lysophosphatidic acid (LPA) and lysophosphatidylserine (LysoPS).	Phosphatidylserines	87-105	lipase H	Homo sapiens	33-37
35458682-5	2022	Some extracellular PLA1s exhibit PLA1 activities specific to phosphatidic acid (PA) or phosphatidylserine (PS) and serve to produce lysophospholipid mediators such as lysophosphatidic acid (LPA) and lysophosphatidylserine (LysoPS).	Phosphatidylserines	107-109	lipase H	Homo sapiens	33-37
35297954-3	2022	To study the role of PS in spine pruning by microglia in vivo, we developed an inducible transgenic mouse line, in which the exposed PS is masked by a dominant-negative form of milk fat globule-EGF-factor 8 (MFG-E8), MFG-E8D89E.	Phosphatidylserines	21-23	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	177-206
35297954-3	2022	To study the role of PS in spine pruning by microglia in vivo, we developed an inducible transgenic mouse line, in which the exposed PS is masked by a dominant-negative form of milk fat globule-EGF-factor 8 (MFG-E8), MFG-E8D89E.	Phosphatidylserines	133-135	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	177-206
35433679-2	2022	SERINC2-4 are carrier proteins that incorporate the polar amino acid serine into membranes to facilitate the synthesis of phosphatidylserine and sphingolipids.	Phosphatidylserines	122-140	serine incorporator 2	Homo sapiens	0-9
35278131-10	2022	Haploinsufficiency of ATP11A, the phospholipid flippase that specially transports phosphatidylserine (PS) and phosphatidylethanolamine (PE), could leave cells with PS/PE at the extracellular side vulnerable to phagocytic degradation.	Phosphatidylserines	82-100	ATPase phospholipid transporting 11A	Homo sapiens	22-28
35278131-10	2022	Haploinsufficiency of ATP11A, the phospholipid flippase that specially transports phosphatidylserine (PS) and phosphatidylethanolamine (PE), could leave cells with PS/PE at the extracellular side vulnerable to phagocytic degradation.	Phosphatidylserines	102-104	ATPase phospholipid transporting 11A	Homo sapiens	22-28
35278131-10	2022	Haploinsufficiency of ATP11A, the phospholipid flippase that specially transports phosphatidylserine (PS) and phosphatidylethanolamine (PE), could leave cells with PS/PE at the extracellular side vulnerable to phagocytic degradation.	Phosphatidylserines	164-166	ATPase phospholipid transporting 11A	Homo sapiens	22-28
35278131-11	2022	Given that surface PS can be pharmaceutically targeted, hearing loss due to ATP11A could potentially be treated.	Phosphatidylserines	19-21	ATPase phospholipid transporting 11A	Homo sapiens	76-82
35199998-3	2022	Herein, a kind of nitric oxide (NO)-driven carrier-free nanomotor based on the reaction between trehalose (Tr, one of the mTOR-independent autophagy inducers), L-arginine (Arg), and phosphatidylserine (PS) is reported.	Phosphatidylserines	182-200	coagulation factor II thrombin receptor	Homo sapiens	107-109
35199998-3	2022	Herein, a kind of nitric oxide (NO)-driven carrier-free nanomotor based on the reaction between trehalose (Tr, one of the mTOR-independent autophagy inducers), L-arginine (Arg), and phosphatidylserine (PS) is reported.	Phosphatidylserines	182-200	mechanistic target of rapamycin kinase	Homo sapiens	122-126
35199998-3	2022	Herein, a kind of nitric oxide (NO)-driven carrier-free nanomotor based on the reaction between trehalose (Tr, one of the mTOR-independent autophagy inducers), L-arginine (Arg), and phosphatidylserine (PS) is reported.	Phosphatidylserines	182-200	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	172-175
35226022-0	2022	Membrane phosphatidylserine allosterically regulates the cytosolic phospholipase A2 activity via an electrostatic-switch mechanism.	Phosphatidylserines	9-27	phospholipase A2 group IVA	Homo sapiens	57-83
35108019-5	2022	Since TIM-1 can also directly interact with PS at the single-molecule level, we also confirmed that TIM-1 acts as dual-function receptors of EBOV.	Phosphatidylserines	44-46	hepatitis A virus cellular receptor 1	Homo sapiens	6-11
35108019-5	2022	Since TIM-1 can also directly interact with PS at the single-molecule level, we also confirmed that TIM-1 acts as dual-function receptors of EBOV.	Phosphatidylserines	44-46	hepatitis A virus cellular receptor 1	Homo sapiens	100-105
35140185-1	2022	A high extracellular adenosine triphosphate (ATP) concentration rapidly and reversibly exposes phosphatidylserine (PtdSer) in T cells by binding to the P2X7 receptor, which ultimately leads to necrosis.	Phosphatidylserines	95-113	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	152-165
35140185-1	2022	A high extracellular adenosine triphosphate (ATP) concentration rapidly and reversibly exposes phosphatidylserine (PtdSer) in T cells by binding to the P2X7 receptor, which ultimately leads to necrosis.	Phosphatidylserines	115-121	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	152-165
35140185-8	2022	Xk and Vps13a formed a complex in mouse splenic T cells, and Xk was crucial for ATP-induced PtdSer exposure and cytolysis in CD25+CD4+ T cells.	Phosphatidylserines	92-98	interleukin 2 receptor, alpha chain	Mus musculus	125-129
35207106-6	2022	We propose that scramblase-dependent externalization of the negatively charged phospholipid phosphatidylserine (PS) plays an important role in the final activation step of ADAM10 and ADAM17.	Phosphatidylserines	92-110	ADAM metallopeptidase domain 10	Homo sapiens	172-178
35207106-6	2022	We propose that scramblase-dependent externalization of the negatively charged phospholipid phosphatidylserine (PS) plays an important role in the final activation step of ADAM10 and ADAM17.	Phosphatidylserines	92-110	ADAM metallopeptidase domain 17	Homo sapiens	183-189
35207106-6	2022	We propose that scramblase-dependent externalization of the negatively charged phospholipid phosphatidylserine (PS) plays an important role in the final activation step of ADAM10 and ADAM17.	Phosphatidylserines	112-114	ADAM metallopeptidase domain 10	Homo sapiens	172-178
35207106-6	2022	We propose that scramblase-dependent externalization of the negatively charged phospholipid phosphatidylserine (PS) plays an important role in the final activation step of ADAM10 and ADAM17.	Phosphatidylserines	112-114	ADAM metallopeptidase domain 17	Homo sapiens	183-189
35080915-3	2022	To this end, we created liposome-based platelet-mimicking procoagulant nanoparticles (PPNs) that can expose the phospholipid phosphatidylserine on their surface in response to plasmin.	Phosphatidylserines	125-143	plasminogen	Homo sapiens	176-183
35080915-5	2022	We also showed that this phosphatidylserine exposed on the PPN surface could restore and enhance thrombin generation and fibrin formation in human plasma depleted of platelets.	Phosphatidylserines	25-43	coagulation factor II, thrombin	Homo sapiens	97-105
35059910-8	2022	It induced apoptosis by phosphatidylserine (PS) exposure together with caspase-3 and PARP cleavage and arrested the cell cycle slightly at the S phase.	Phosphatidylserines	24-42	caspase 3	Homo sapiens	71-80
35059910-8	2022	It induced apoptosis by phosphatidylserine (PS) exposure together with caspase-3 and PARP cleavage and arrested the cell cycle slightly at the S phase.	Phosphatidylserines	24-42	poly(ADP-ribose) polymerase 1	Homo sapiens	85-89
35059910-8	2022	It induced apoptosis by phosphatidylserine (PS) exposure together with caspase-3 and PARP cleavage and arrested the cell cycle slightly at the S phase.	Phosphatidylserines	44-46	caspase 3	Homo sapiens	71-80
35207044-3	2022	We recently presented evidence that ANO6-dependent surface exposure of phosphatidylserine (PS) is pivotal for the disintegrin-like metalloproteases ADAM10 and ADAM17 to exert their sheddase function.	Phosphatidylserines	71-89	anoctamin 6	Homo sapiens	36-40
35207044-3	2022	We recently presented evidence that ANO6-dependent surface exposure of phosphatidylserine (PS) is pivotal for the disintegrin-like metalloproteases ADAM10 and ADAM17 to exert their sheddase function.	Phosphatidylserines	71-89	ADAM metallopeptidase domain 10	Homo sapiens	148-154
35207044-3	2022	We recently presented evidence that ANO6-dependent surface exposure of phosphatidylserine (PS) is pivotal for the disintegrin-like metalloproteases ADAM10 and ADAM17 to exert their sheddase function.	Phosphatidylserines	71-89	ADAM metallopeptidase domain 17	Homo sapiens	159-165
35207044-3	2022	We recently presented evidence that ANO6-dependent surface exposure of phosphatidylserine (PS) is pivotal for the disintegrin-like metalloproteases ADAM10 and ADAM17 to exert their sheddase function.	Phosphatidylserines	91-93	anoctamin 6	Homo sapiens	36-40
35207044-3	2022	We recently presented evidence that ANO6-dependent surface exposure of phosphatidylserine (PS) is pivotal for the disintegrin-like metalloproteases ADAM10 and ADAM17 to exert their sheddase function.	Phosphatidylserines	91-93	ADAM metallopeptidase domain 10	Homo sapiens	148-154
35207044-3	2022	We recently presented evidence that ANO6-dependent surface exposure of phosphatidylserine (PS) is pivotal for the disintegrin-like metalloproteases ADAM10 and ADAM17 to exert their sheddase function.	Phosphatidylserines	91-93	ADAM metallopeptidase domain 17	Homo sapiens	159-165
35207044-7	2022	Annexin V-staining demonstrated increased externalisation of PS in ANO4/ANO9-overexpressing cells.	Phosphatidylserines	61-63	annexin A5	Homo sapiens	0-9
35207044-7	2022	Annexin V-staining demonstrated increased externalisation of PS in ANO4/ANO9-overexpressing cells.	Phosphatidylserines	61-63	anoctamin 4	Homo sapiens	67-71
35207044-7	2022	Annexin V-staining demonstrated increased externalisation of PS in ANO4/ANO9-overexpressing cells.	Phosphatidylserines	61-63	anoctamin 9	Homo sapiens	72-76
35207044-8	2022	Competition experiments with the soluble PS-headgroup phosphorylserine indicated that the ANO4/ANO9 effects were due to increased PS exposure.	Phosphatidylserines	41-43	anoctamin 4	Homo sapiens	90-94
35207044-8	2022	Competition experiments with the soluble PS-headgroup phosphorylserine indicated that the ANO4/ANO9 effects were due to increased PS exposure.	Phosphatidylserines	41-43	anoctamin 9	Homo sapiens	95-99
35207044-8	2022	Competition experiments with the soluble PS-headgroup phosphorylserine indicated that the ANO4/ANO9 effects were due to increased PS exposure.	Phosphatidylserines	130-132	anoctamin 4	Homo sapiens	90-94
35207044-8	2022	Competition experiments with the soluble PS-headgroup phosphorylserine indicated that the ANO4/ANO9 effects were due to increased PS exposure.	Phosphatidylserines	130-132	anoctamin 9	Homo sapiens	95-99
34559203-7	2022	Cytosolic phospholipase A2 (cPLA2) activity and autotaxin (ATX, a secreted lysophospholipase D) secretion were upregulated by Hcy, leading to membrane phospholipid hydrolysis and PS exposure.	Phosphatidylserines	179-181	phospholipase A2 group IVA	Homo sapiens	0-26
34559203-7	2022	Cytosolic phospholipase A2 (cPLA2) activity and autotaxin (ATX, a secreted lysophospholipase D) secretion were upregulated by Hcy, leading to membrane phospholipid hydrolysis and PS exposure.	Phosphatidylserines	179-181	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	48-57
35636929-2	2022	The main ligands of Mertk are Vitamin K-modified endogenous proteins Gas6 and Protein S (ProS1), heterobifunctional modular proteins that bind Mertk via two carboxyl-terminal laminin-like globular (LG) domains, and an N-terminal Gla domain that binds anionic phospholipids, whereby externalized phosphatidylserine (PS) on stressed viable and caspase-activated apoptotic cells is most emblematic.	Phosphatidylserines	295-313	MER proto-oncogene, tyrosine kinase	Homo sapiens	20-25
35636929-2	2022	The main ligands of Mertk are Vitamin K-modified endogenous proteins Gas6 and Protein S (ProS1), heterobifunctional modular proteins that bind Mertk via two carboxyl-terminal laminin-like globular (LG) domains, and an N-terminal Gla domain that binds anionic phospholipids, whereby externalized phosphatidylserine (PS) on stressed viable and caspase-activated apoptotic cells is most emblematic.	Phosphatidylserines	295-313	growth arrest specific 6	Homo sapiens	69-73
35636929-2	2022	The main ligands of Mertk are Vitamin K-modified endogenous proteins Gas6 and Protein S (ProS1), heterobifunctional modular proteins that bind Mertk via two carboxyl-terminal laminin-like globular (LG) domains, and an N-terminal Gla domain that binds anionic phospholipids, whereby externalized phosphatidylserine (PS) on stressed viable and caspase-activated apoptotic cells is most emblematic.	Phosphatidylserines	295-313	protein S	Homo sapiens	89-94
35636929-2	2022	The main ligands of Mertk are Vitamin K-modified endogenous proteins Gas6 and Protein S (ProS1), heterobifunctional modular proteins that bind Mertk via two carboxyl-terminal laminin-like globular (LG) domains, and an N-terminal Gla domain that binds anionic phospholipids, whereby externalized phosphatidylserine (PS) on stressed viable and caspase-activated apoptotic cells is most emblematic.	Phosphatidylserines	295-313	MER proto-oncogene, tyrosine kinase	Homo sapiens	143-148
35636929-2	2022	The main ligands of Mertk are Vitamin K-modified endogenous proteins Gas6 and Protein S (ProS1), heterobifunctional modular proteins that bind Mertk via two carboxyl-terminal laminin-like globular (LG) domains, and an N-terminal Gla domain that binds anionic phospholipids, whereby externalized phosphatidylserine (PS) on stressed viable and caspase-activated apoptotic cells is most emblematic.	Phosphatidylserines	315-317	MER proto-oncogene, tyrosine kinase	Homo sapiens	20-25
35636929-2	2022	The main ligands of Mertk are Vitamin K-modified endogenous proteins Gas6 and Protein S (ProS1), heterobifunctional modular proteins that bind Mertk via two carboxyl-terminal laminin-like globular (LG) domains, and an N-terminal Gla domain that binds anionic phospholipids, whereby externalized phosphatidylserine (PS) on stressed viable and caspase-activated apoptotic cells is most emblematic.	Phosphatidylserines	315-317	growth arrest specific 6	Homo sapiens	69-73
35636929-2	2022	The main ligands of Mertk are Vitamin K-modified endogenous proteins Gas6 and Protein S (ProS1), heterobifunctional modular proteins that bind Mertk via two carboxyl-terminal laminin-like globular (LG) domains, and an N-terminal Gla domain that binds anionic phospholipids, whereby externalized phosphatidylserine (PS) on stressed viable and caspase-activated apoptotic cells is most emblematic.	Phosphatidylserines	315-317	protein S	Homo sapiens	89-94
35636929-2	2022	The main ligands of Mertk are Vitamin K-modified endogenous proteins Gas6 and Protein S (ProS1), heterobifunctional modular proteins that bind Mertk via two carboxyl-terminal laminin-like globular (LG) domains, and an N-terminal Gla domain that binds anionic phospholipids, whereby externalized phosphatidylserine (PS) on stressed viable and caspase-activated apoptotic cells is most emblematic.	Phosphatidylserines	315-317	MER proto-oncogene, tyrosine kinase	Homo sapiens	143-148
35636929-3	2022	Recent studies indicate that Vitamin K-dependent gamma-carboxylation on the N-terminal Gla domain of Gas6 and Protein S is necessary for PS binding and Mertk activation, implying that Mertk is preferentially active in tissues where there is high externalized PS, such as the tumor microenvironment (TME) and acute virally infected tissues.	Phosphatidylserines	137-139	growth arrest specific 6	Homo sapiens	101-105
35636929-3	2022	Recent studies indicate that Vitamin K-dependent gamma-carboxylation on the N-terminal Gla domain of Gas6 and Protein S is necessary for PS binding and Mertk activation, implying that Mertk is preferentially active in tissues where there is high externalized PS, such as the tumor microenvironment (TME) and acute virally infected tissues.	Phosphatidylserines	137-139	MER proto-oncogene, tyrosine kinase	Homo sapiens	184-189
35636929-3	2022	Recent studies indicate that Vitamin K-dependent gamma-carboxylation on the N-terminal Gla domain of Gas6 and Protein S is necessary for PS binding and Mertk activation, implying that Mertk is preferentially active in tissues where there is high externalized PS, such as the tumor microenvironment (TME) and acute virally infected tissues.	Phosphatidylserines	259-261	growth arrest specific 6	Homo sapiens	101-105
35636929-3	2022	Recent studies indicate that Vitamin K-dependent gamma-carboxylation on the N-terminal Gla domain of Gas6 and Protein S is necessary for PS binding and Mertk activation, implying that Mertk is preferentially active in tissues where there is high externalized PS, such as the tumor microenvironment (TME) and acute virally infected tissues.	Phosphatidylserines	259-261	MER proto-oncogene, tyrosine kinase	Homo sapiens	184-189
35585308-0	2022	TIM4-Affinity Methods Targeting Phosphatidylserine for Isolation or Detection of Extracellular Vesicles.	Phosphatidylserines	32-50	T cell immunoglobulin and mucin domain containing 4	Homo sapiens	0-4
35585308-7	2022	In this chapter, we present a TIM4-affinity isolation method that targets phosphatidylserine (PS), a component of the SEV membrane.	Phosphatidylserines	74-92	T cell immunoglobulin and mucin domain containing 4	Homo sapiens	30-34
35585308-7	2022	In this chapter, we present a TIM4-affinity isolation method that targets phosphatidylserine (PS), a component of the SEV membrane.	Phosphatidylserines	94-96	T cell immunoglobulin and mucin domain containing 4	Homo sapiens	30-34
35585308-8	2022	TIM4 binds to PS in a Ca2+-dependent manner, which enables the elution of intact SEVs from TIM4-beads in the presence of the chelating reagent ethylenediaminetetraacetic acid (EDTA).	Phosphatidylserines	14-16	T cell immunoglobulin and mucin domain containing 4	Homo sapiens	0-4
35585308-8	2022	TIM4 binds to PS in a Ca2+-dependent manner, which enables the elution of intact SEVs from TIM4-beads in the presence of the chelating reagent ethylenediaminetetraacetic acid (EDTA).	Phosphatidylserines	14-16	T cell immunoglobulin and mucin domain containing 4	Homo sapiens	91-95
35226805-3	2022	We recently found that phosphatidylserine (PS) binding to Tim-3 can suppress NK cell activation.	Phosphatidylserines	23-41	hepatitis A virus cellular receptor 2	Homo sapiens	58-63
35226805-3	2022	We recently found that phosphatidylserine (PS) binding to Tim-3 can suppress NK cell activation.	Phosphatidylserines	43-45	hepatitis A virus cellular receptor 2	Homo sapiens	58-63
2608070-0	1989	Inhibition of phosphatidylserine synthesis induced by triggering CD2 or the CD3-TCR complex in a human T cell line.	Phosphatidylserines	14-32	CD2 molecule	Homo sapiens	65-68
2608070-2	1989	Activation of Jurkat T cells with phytohemagglutinin, CD3 or CD2 mAbs results in a marked inhibition of phosphatidylserine (PS) synthesis.	Phosphatidylserines	104-122	CD2 molecule	Homo sapiens	61-64
2608070-2	1989	Activation of Jurkat T cells with phytohemagglutinin, CD3 or CD2 mAbs results in a marked inhibition of phosphatidylserine (PS) synthesis.	Phosphatidylserines	124-126	CD2 molecule	Homo sapiens	61-64
2608070-3	1989	Monitoring PS synthesis in T cells shows that: (i) after modulation of CD3 molecules the cells become refractory to further treatment with CD3 mAbs as well as to a further challenge with CD2 mAbs; and (ii) treatment of T cells with fluoride ions and cholera toxin, two known effectors of guanosine triphosphate-binding proteins, also resulted in a strong inhibition of the synthesis of this phospholipid.	Phosphatidylserines	11-13	CD2 molecule	Homo sapiens	187-190
2483129-1	1989	Interaction of substance P with electrically neutral, planar lipid bilayers prepared from 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and with anionic bilayers prepared from mixtures of 1,2-dioleoyl-sn-glycero-3-phosphocholine and brain phosphatidylserine was measured using the capacitance minimization method for monitoring the membrane surface potential caused by the positive charges and electric dipole moment of adsorbed peptide.	Phosphatidylserines	242-260	tachykinin precursor 1	Homo sapiens	15-26
2811608-1	1989	Previous studies on alpha-lactalbumin induced fusion of phosphatidylserine/phosphatidylethanolamine vesicles are extended to vesicles composed of various combinations of phosphatidylserine, phosphatidylethanolamine, phosphatidylcholine and cardiolipin.	Phosphatidylserines	56-74	lactalbumin alpha	Homo sapiens	20-37
2811608-1	1989	Previous studies on alpha-lactalbumin induced fusion of phosphatidylserine/phosphatidylethanolamine vesicles are extended to vesicles composed of various combinations of phosphatidylserine, phosphatidylethanolamine, phosphatidylcholine and cardiolipin.	Phosphatidylserines	170-188	lactalbumin alpha	Homo sapiens	20-37
2551742-6	1989	The 80-kDa DGK was markedly activated by 10-20 microM sphingosine as well as by the known anionic activators such as phosphatidylserine and deoxycholate.	Phosphatidylserines	117-135	diacylglycerol kinase beta	Homo sapiens	11-14
2768260-1	1989	We have shown that purified bovine soluble dopamine beta-hydroxylase can reconstitute onto preformed phosphatidylserine containing vesicles.	Phosphatidylserines	101-119	dopamine beta-hydroxylase	Bos taurus	43-68
2768260-7	1989	We propose that noncovalently bound phosphatidylserine moieties, which copurify with the membrane bound form of the enzyme, alone are responsible for anchoring membranous dopamine beta-hydroxylase to chromaffin granule and model membranes.	Phosphatidylserines	36-54	dopamine beta-hydroxylase	Bos taurus	171-196
2819080-3	1989	We apply this model here to compare the binding of human prothrombin and factor X/Xa to phosphatidylglycerol (PG)- and phosphatidylserine (PS)-containing small unilamellar vesicles measured via relative light scattering.	Phosphatidylserines	119-137	coagulation factor II, thrombin	Homo sapiens	57-68
2779522-2	1989	Melittin was previously shown to inhibit Ca2+- and phosphatidylserine (PS)-dependent PKC activity with an inhibitory potency that was reduced as the PS concentration was elevated.	Phosphatidylserines	51-69	proline rich transmembrane protein 2	Homo sapiens	85-88
2779522-2	1989	Melittin was previously shown to inhibit Ca2+- and phosphatidylserine (PS)-dependent PKC activity with an inhibitory potency that was reduced as the PS concentration was elevated.	Phosphatidylserines	71-73	proline rich transmembrane protein 2	Homo sapiens	85-88
2779522-2	1989	Melittin was previously shown to inhibit Ca2+- and phosphatidylserine (PS)-dependent PKC activity with an inhibitory potency that was reduced as the PS concentration was elevated.	Phosphatidylserines	149-151	proline rich transmembrane protein 2	Homo sapiens	85-88
2779522-3	1989	In this report, we found that melittin could inhibit activation of PKC by Ca2+ and PS, with an IC50 of 3 microM.	Phosphatidylserines	83-85	proline rich transmembrane protein 2	Homo sapiens	67-70
2779522-4	1989	When the enzyme activity was released from regulation by Ca2+ and PS by the generation of an active catalytic fragment of PKC through limited proteolysis, melittin inhibited the enzyme activity with an IC50 of 25 microM.	Phosphatidylserines	66-68	proline rich transmembrane protein 2	Homo sapiens	122-125
2757386-3	1989	Treatment of phenylhydrazine-exposed erythrocytes either with bee venom phospholipase A2 or with trinitrobenzenesulfonic acid indicated that phosphatidylserine (PS), which is the only phospholipid not formally present on the outer leaflet of the membrane, was translocated to the outer surface of the cell membrane.	Phosphatidylserines	141-159	phospholipase A2 group IB	Homo sapiens	72-88
2757386-3	1989	Treatment of phenylhydrazine-exposed erythrocytes either with bee venom phospholipase A2 or with trinitrobenzenesulfonic acid indicated that phosphatidylserine (PS), which is the only phospholipid not formally present on the outer leaflet of the membrane, was translocated to the outer surface of the cell membrane.	Phosphatidylserines	161-163	phospholipase A2 group IB	Homo sapiens	72-88
2546942-7	1989	From the dependence of the energy transfer upon the acceptor density and assuming kappa 2 = 2/3, the distance of closest approach between a dye in the active site of the thrombin-thrombomodulin complex and a dye at the membrane surface was determined to average 66 A (65 +/- 3 A for phosphatidylcholine vesicles without and 67 +/- 5 A for those with 20% phosphatidylserine).	Phosphatidylserines	354-372	coagulation factor II, thrombin	Homo sapiens	170-178
2758043-1	1989	The alpha-lactalbumin segment which penetrates into phosphatidylserine/phosphatidylethanolamine vesicle bilayer under acidic condition was photoactively labeled with 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine [( 125I]TID) which had been partitioned into the hydrophobic interior of the bilayer.	Phosphatidylserines	52-70	lactalbumin alpha	Homo sapiens	4-21
2476115-3	1989	In the present study it is demonstrated that, in the presence of hirudin, the most potent known inhibitor of thrombin, human protein C can be activated by human factor Xa (20 nM), but by a thrombomodulin-independent mechanism requiring only the presence of Ca2+ and phospholipid vesicles bearing a high proportion of negative charges (30-75% phosphatidylserine, depending on the conditions).	Phosphatidylserines	342-360	coagulation factor II, thrombin	Homo sapiens	109-117
2752025-0	1989	Infrared and 31P-NMR studies of the interaction of Mg2+ with phosphatidylserines: effect of hydrocarbon chain unsaturation.	Phosphatidylserines	61-80	mucin 7, secreted	Homo sapiens	51-54
2804168-7	1989	It was shown that in contrast to the phosphatidylserine effect, the dependence of the protein kinase activity on phosphatidylinositol concentration is described by two apparent activation constants, which may be suggestive of the existence of two lipid-binding sites in the enzyme molecule: the enzyme affinity for phosphatidylinositol is 4 times higher than for phosphatidylserine.	Phosphatidylserines	37-55	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	86-100
2804168-7	1989	It was shown that in contrast to the phosphatidylserine effect, the dependence of the protein kinase activity on phosphatidylinositol concentration is described by two apparent activation constants, which may be suggestive of the existence of two lipid-binding sites in the enzyme molecule: the enzyme affinity for phosphatidylinositol is 4 times higher than for phosphatidylserine.	Phosphatidylserines	363-381	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	86-100
2542284-2	1989	When either the solubilized Na+-Ca2+ exchanger or the Na+,K+-ATPase is reconstituted into phosphatidylcholine (PC):phosphatidylserine (30:50 by weight) vesicles, high cholesterol levels (20% by weight) are required for activity to be expressed.	Phosphatidylserines	115-133	solute carrier family 8 member A1	Homo sapiens	28-46
2540712-1	1989	Fusion of phosphatidylserine/phosphatidylethanolamine (1/1) vesicles induced by cytochrome c is studied at a wide range of pH values.	Phosphatidylserines	10-28	cytochrome c, somatic	Homo sapiens	80-92
2524476-3	1989	At 1.2 mM Ca2+, 0.50 M ionic strength, pH 7.4, 25 degrees C, fluorescein-labeled PAP-I bound to phospholipid vesicles containing 80% phosphatidylcholine, 20% phosphatidylserine with a Kd of 1.2 +/- 0.2 nM (mean +/- S.D.).	Phosphatidylserines	158-176	annexin A5	Homo sapiens	81-86
2497105-7	1989	On the other hand, phosphatidylcholine vesicles containing either phosphatidylserine or phosphatidylinositol strongly interacted with synapsin I.	Phosphatidylserines	66-84	synapsin I	Homo sapiens	134-144
2730870-2	1989	Stimulation of platelets with the Ca2+ ionophore A23187 or combined action of collagen plus thrombin results in a rapid loss of the asymmetric distribution of PS.	Phosphatidylserines	159-161	coagulation factor II, thrombin	Homo sapiens	92-100
2730870-4	1989	PS exposure is sensitively measured as the catalytic potential of platelets to enhance the rate of thrombin formation by the enzyme complex factor Xa-factor Va, since this reaction is essentially dependent on the presence of a PS-containing lipid surface.	Phosphatidylserines	0-2	coagulation factor II, thrombin	Homo sapiens	99-107
2730870-4	1989	PS exposure is sensitively measured as the catalytic potential of platelets to enhance the rate of thrombin formation by the enzyme complex factor Xa-factor Va, since this reaction is essentially dependent on the presence of a PS-containing lipid surface.	Phosphatidylserines	227-229	coagulation factor II, thrombin	Homo sapiens	99-107
2924918-3	1989	A fourth peak eluted at high phosphate concentration was activated by TPA and RX in the presence of PS and the absence of calcium.	Phosphatidylserines	100-102	plasminogen activator, tissue type	Homo sapiens	70-73
2704040-2	1989	By measuring surface pressure at constant surface area, p68 was found to interact in a Ca2+ -dependent manner specifically with phosphatidylethanolamine, less so with phosphatidylserine and not at all with phosphatidylcholine.	Phosphatidylserines	167-185	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	56-59
2537172-10	1989	Activation of cytosolic PKC by diolein, phosphatidylserine, and calcium caused phosphorylation of many cytosolic proteins, including those having apparent mol wt of 39K, 35K, 33K, 25K, 19K, and 16K.	Phosphatidylserines	40-58	protein kinase C, gamma	Rattus norvegicus	24-27
2783556-3	1989	The incorporation of these compounds within appropriately designed liposomes composed of distearoylphosphatidylcholine and phosphatidylserine (DSPC/PS) increased their ability to induce CSF activity in vivo but completely abrogated their ability to induce CSF activity in vitro.	Phosphatidylserines	123-141	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	186-189
2783556-3	1989	The incorporation of these compounds within appropriately designed liposomes composed of distearoylphosphatidylcholine and phosphatidylserine (DSPC/PS) increased their ability to induce CSF activity in vivo but completely abrogated their ability to induce CSF activity in vitro.	Phosphatidylserines	123-141	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	256-259
2540823-1	1989	Ca2+ binding between lamellae of phosphatidylserine (PS) and phosphatidylcholine (PC) gives rise to a rigid phase of Ca(PS)2.	Phosphatidylserines	33-51	surfactant protein C	Homo sapiens	82-84
2524473-3	1989	Because this protein had the ability to bind phospholipids such as phosphatidylserine, phosphatidylinositol, and cardiolipin in the presence of Ca2+, this protein was designated as calphobindin II (CPB-II).	Phosphatidylserines	67-85	annexin A6	Homo sapiens	181-196
2917687-1	1989	Liposomes containing human choriogonadotropin (hCG) were prepared from phosphatidylserine by the ether injection method.	Phosphatidylserines	71-89	glycoprotein hormones, alpha polypeptide	Homo sapiens	47-50
2922759-5	1989	In a related study, purified phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine were also found to activate the partially separated NTE activity in a concentration-dependent manner while phosphatidyl-inositol was found to inhibit the same partially separated NTE fraction in a concentration-dependent manner.	Phosphatidylserines	80-98	patatin like phospholipase domain containing 6	Gallus gallus	151-154
2922759-5	1989	In a related study, purified phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine were also found to activate the partially separated NTE activity in a concentration-dependent manner while phosphatidyl-inositol was found to inhibit the same partially separated NTE fraction in a concentration-dependent manner.	Phosphatidylserines	80-98	patatin like phospholipase domain containing 6	Gallus gallus	278-281
2914139-0	1989	Aminophospholipid translocase in the plasma membrane of Friend erythroleukemic cells can induce an asymmetric topology for phosphatidylserine but not for phosphatidylethanolamine.	Phosphatidylserines	123-141	ATPase, class I, type 8B, member 1	Mus musculus	0-29
2528395-4	1989	These proteins with the 37 kDa protein share the functional properties of the two well-known Ca2+-binding proteins, named calpactin I and calpactin II; they were able to interact with F-actin, brain spectrin (fodrin) and phosphatidylserine-liposomes in a Ca2+-dependent manner.	Phosphatidylserines	221-239	annexin A1	Sus scrofa	138-150
2702039-2	1989	TGF-beta was encapsulated in multilamellar liposomes consisting of phosphatidylcholine (PC) or PC and phosphatidylserine (PS) at a 7:3 molar ratio.	Phosphatidylserines	102-120	transforming growth factor beta 1	Homo sapiens	0-8
2702039-2	1989	TGF-beta was encapsulated in multilamellar liposomes consisting of phosphatidylcholine (PC) or PC and phosphatidylserine (PS) at a 7:3 molar ratio.	Phosphatidylserines	122-124	transforming growth factor beta 1	Homo sapiens	0-8
2577121-1	1989	Activation of Jurkat T lymphocytes to produce IL2 is accompanied by a strong inhibition of phosphatidylserine (PS) synthesis.	Phosphatidylserines	91-109	interleukin 2	Homo sapiens	46-49
2577121-1	1989	Activation of Jurkat T lymphocytes to produce IL2 is accompanied by a strong inhibition of phosphatidylserine (PS) synthesis.	Phosphatidylserines	111-113	interleukin 2	Homo sapiens	46-49
2914331-5	1989	DEHP non-competitively blocked activation of PK-C by either phosphatidyl serine or calcium ion.	Phosphatidylserines	60-79	protein kinase C, gamma	Rattus norvegicus	45-49
2495252-1	1989	Multilamellar liposomes of phosphatidylcholine and phosphatidylserine at a 7:3 molar ratio significantly inhibited activation of murine resident peritoneal macrophages by recombinant murine interferon-gamma for cytotoxicity against amastigotes of the protozoan parasite Leishmania major; other macrophage effector functions, such as particle phagocytosis or tumoricidal activity, were unaffected.	Phosphatidylserines	51-69	interferon gamma	Mus musculus	190-206
2851994-3	1988	In a purified human system, vitamin K-dependent proteins such as factor X, prothrombin and prothrombin fragment 1 were able to inhibit protein C activation by the thrombin-thrombomodulin complex, using either detergent-solubilized thrombomodulin or thrombomodulin reconstituted into vesicles consisting of phosphatidylcholine and phosphatidylserine (1:1, w/w).	Phosphatidylserines	330-348	coagulation factor II, thrombin	Homo sapiens	78-86
2851994-3	1988	In a purified human system, vitamin K-dependent proteins such as factor X, prothrombin and prothrombin fragment 1 were able to inhibit protein C activation by the thrombin-thrombomodulin complex, using either detergent-solubilized thrombomodulin or thrombomodulin reconstituted into vesicles consisting of phosphatidylcholine and phosphatidylserine (1:1, w/w).	Phosphatidylserines	330-348	thrombomodulin	Homo sapiens	172-186
2850802-6	1988	Vasopressin doubled the activity of diacylglycerol kinase in the plasma-membrane fraction when the enzyme was assayed with phosphatidylserine rather than deoxycholate as stimulator, and when either 1-stearoyl-2-arachidonoyl-sn-glycerol or 1,2-dioleoyl-sn-glycerol was the substrate.	Phosphatidylserines	123-141	arginine vasopressin	Rattus norvegicus	0-11
2844906-0	1988	IL-1 signaling for IL-2 production in T cells involves a rise in phosphatidylserine synthesis.	Phosphatidylserines	65-83	interleukin 1 alpha	Homo sapiens	0-4
2844906-0	1988	IL-1 signaling for IL-2 production in T cells involves a rise in phosphatidylserine synthesis.	Phosphatidylserines	65-83	interleukin 2	Homo sapiens	19-23
2844906-4	1988	Furthermore, IL-1 did not modify the intracellular level of cGMP and cAMP, suggesting that the observed rise of PS synthesis could play the role of mediator IL-1 action.	Phosphatidylserines	112-114	interleukin 1 alpha	Homo sapiens	157-161
2844906-5	1988	As PS is a necessary cofactor for the activation of protein kinase C, our results suggest strongly that IL-1 modulate protein kinase C activity in the activated lymphocyte through its action on PS synthesis.	Phosphatidylserines	3-5	interleukin 1 alpha	Homo sapiens	104-108
2459224-6	1988	As with release induced by anti-TNP IgE mAb PC1-F-induced release required phosphatidyl serine.	Phosphatidylserines	75-94	minisatellite 6 hypermutable	Mus musculus	44-47
3061458-10	1988	Insulin exhibits a weak but remarkable nonspecific binding to bilayers of pure DMPC and DMPC containing 20% positively charged lipid and a strong binding to DMPC containing negatively charged lipids such as phosphatidylserine or ganglioside (GT1b).	Phosphatidylserines	207-225	insulin	Homo sapiens	0-7
2838082-1	1988	The interaction between cytochrome c and its heme-free precursor apocytochrome c and chemically prepared fragments of these basic proteins with phosphatidylserine containing model membrane systems was studied by differential scanning calorimetry and carboxyfluorescein release experiments.	Phosphatidylserines	144-162	cytochrome c, somatic	Homo sapiens	24-36
2838083-14	1988	Ca2+-inducible exposure of phosphatidylserine, as determined with extracellular phospholipase A2, showed a similar pattern as Ca2+-inducible calpain activity and prothrombinase activity.	Phosphatidylserines	27-45	phospholipase A2 group IB	Homo sapiens	80-96
2838083-14	1988	Ca2+-inducible exposure of phosphatidylserine, as determined with extracellular phospholipase A2, showed a similar pattern as Ca2+-inducible calpain activity and prothrombinase activity.	Phosphatidylserines	27-45	coagulation factor X	Homo sapiens	162-176
2844256-2	1988	The pH and salt dependences of the interaction of phosphatidic acid, phosphatidylserine, and stearic acid with myelin proteolipid apoprotein (PLP) in dimyristoylphosphatidylcholine (DMPC) recombinants have been studied by electron spin resonance spectroscopy, using spin-labeled lipids.	Phosphatidylserines	69-87	proteolipid protein 1	Homo sapiens	142-145
2971392-6	1988	In one such case involving liposomes composed of PA/PS/PE/phosphatidylcholine (PC) (10:15:65:10), synexin reduced the fusion rate constant by 50%.	Phosphatidylserines	52-54	annexin A7	Homo sapiens	98-105
3170511-4	1988	The L929 cells excreted the degradation products of TNF into the culture medium, and this medium showed activity for degradation of liposomes composed of phosphatidylserine and phosphatidylcholine.	Phosphatidylserines	154-172	tumor necrosis factor	Mus musculus	52-55
2833432-4	1988	The results of the study indicate that stimulation of 1-14C-AA-prelabelled PMNs with BK liberates AA mainly from phosphatidylinositol, while A23187 causes release of AA from phosphatidylcholine, phosphatidylethanolamine, and possibly phosphatidylserine.	Phosphatidylserines	234-252	kininogen 1	Homo sapiens	85-87
3337815-7	1988	Furthermore, alteration of receptor structure by added phospholipase occurs very rapidly, which is consistent with the observation of rapid in situ phospholipase A2 hydrolysis of membrane phospholipids, particularly highly unsaturated phosphatidylethanolamine and phosphatidylserine.	Phosphatidylserines	264-282	phospholipase A2 group IB	Homo sapiens	148-164
3349050-5	1988	At saturation, there was 9 X 10(-3) pmol of protein 4.1 bound/pmol of PS with a Kd of 3.3 X 10(-7) M. When the protein 4.1 containing liposomes were examined in an electron microscope, the protein 4.1 was found uniformly decorating the vesicles in a rosettelike fashion.	Phosphatidylserines	70-72	erythrocyte membrane protein band 4.1	Homo sapiens	44-55
3337803-3	1988	Protein 4.1 penetrated into monolayers of brain phosphatidylserine (PS) and egg phosphatidylcholine (PC), even above surface pressures of 30 mN/m.	Phosphatidylserines	68-70	erythrocyte membrane protein band 4.1	Homo sapiens	0-11
3337803-4	1988	Protein 4.1 increased the permeability of negatively charged PS, but not PC, liposomes, measured as the increase in fluorescence when encapsulated 1-aminonaphthalene-3,6,8-trisulfonic acid (ANTS) and p-xylenebispyridinium bromide (DPX) or carboxyfluorescein were released into the medium.	Phosphatidylserines	61-63	erythrocyte membrane protein band 4.1	Homo sapiens	0-11
3337804-3	1988	The equilibration of the newly introduced PS over the two halves of the bilayer was monitored by treatment of the cells with phospholipase A2 which selectively hydrolyzes only those molecules present in the outer membrane leaflet.	Phosphatidylserines	42-44	phospholipase A2 group IB	Homo sapiens	125-141
3337804-4	1988	Within 1 h after insertion into fresh RSCs, only 10% of the labeled PS was accessible to the action of phospholipase A2.	Phosphatidylserines	68-70	phospholipase A2 group IB	Homo sapiens	103-119
3337804-6	1988	Prolonged deoxygenation of RSCs, deprived of their ATP after incorporation of radiolabeled PS, caused enhanced phospholipase A2-induced hydrolysis of radiolabeled PS.	Phosphatidylserines	91-93	phospholipase A2 group IB	Homo sapiens	111-127
3337804-7	1988	Similarly, phospholipase A2-induced hydrolysis of endogenous PS in intact RSCs was markedly enhanced when ATP-depleted, but not when fresh cells, were incubated under nitrogen for 3.5 h. Deoxygenated ATP-depleted RSCs markedly enhanced the rate of thrombin formation in the presence of purified coagulation factors Xa, Va, prothrombin and Ca2+.	Phosphatidylserines	61-63	phospholipase A2 group IB	Homo sapiens	11-27
3337804-7	1988	Similarly, phospholipase A2-induced hydrolysis of endogenous PS in intact RSCs was markedly enhanced when ATP-depleted, but not when fresh cells, were incubated under nitrogen for 3.5 h. Deoxygenated ATP-depleted RSCs markedly enhanced the rate of thrombin formation in the presence of purified coagulation factors Xa, Va, prothrombin and Ca2+.	Phosphatidylserines	61-63	coagulation factor II, thrombin	Homo sapiens	248-256
2446664-4	1988	However, myelin basic protein was labeled 2-4-times more when bound to the acidic lipids phosphatidylglycerol, phosphatidylserine, phosphatidic acid, and cerebroside sulfate than when bound to phosphatidylethanolamine, or when in solution in the presence of phosphatidylcholine vesicles.	Phosphatidylserines	111-129	myelin basic protein	Homo sapiens	9-29
3162382-4	1988	Here we report that membranes, which contain phosphatidylserine (PS) as the anionic phospholipid, can be made positively charged by incorporation of stearylamine and still exhibit almost full procoagulant and prothrombin-converting activity.	Phosphatidylserines	65-67	coagulation factor II, thrombin	Homo sapiens	209-220
3335640-7	1988	Addition of purified protein 4.1 to PS liposomes resulted in saturable binding with the extent of binding being proportional to the liposome PS content.	Phosphatidylserines	36-38	erythrocyte membrane protein band 4.1	Homo sapiens	21-32
3121598-2	1987	The present paper demonstrates that latent PAI-1 can be activated by lipid vesicles containing the negatively charged phospholipids phosphatidylserine (PS) or phosphatidylinositol.	Phosphatidylserines	132-150	serpin family E member 1	Homo sapiens	43-48
3121598-2	1987	The present paper demonstrates that latent PAI-1 can be activated by lipid vesicles containing the negatively charged phospholipids phosphatidylserine (PS) or phosphatidylinositol.	Phosphatidylserines	152-154	serpin family E member 1	Homo sapiens	43-48
3121598-5	1987	In mixed phospholipid vesicles containing PS and phosphatidylcholine in various molar ratios, the extent of PAI-1 activation was directly related to the PS content of the phospholipid membrane.	Phosphatidylserines	42-44	serpin family E member 1	Homo sapiens	108-113
3121598-5	1987	In mixed phospholipid vesicles containing PS and phosphatidylcholine in various molar ratios, the extent of PAI-1 activation was directly related to the PS content of the phospholipid membrane.	Phosphatidylserines	153-155	serpin family E member 1	Homo sapiens	108-113
3427105-1	1987	Low-angle neutron scattering is used to study the binding of human prothrombin to small single-bilayer vesicles consisting of phosphatidylcholine and phosphatidylserine (1/1 w/w).	Phosphatidylserines	150-168	coagulation factor II, thrombin	Homo sapiens	67-78
3118953-1	1987	NADPH-cytochrome P-450 reductase, purified from bovine adrenocortical microsomes, was shown to bind in two different modes to liposomal membranes composed of phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine at a molar ratio of 5:3:1.	Phosphatidylserines	208-226	cytochrome p450 oxidoreductase	Bos taurus	0-32
3117114-1	1987	In previous publications, we have shown, by using spin-labeled derivatives, that the translocation of phosphatidylserine and phosphatidylethanolamine from the outer to the inner monolayer of human erythrocyte membrane is a protein-mediated phenomenon, which requires hydrolisable Mg2+-ATP.	Phosphatidylserines	102-120	mucin 7, secreted	Homo sapiens	280-283
2957692-7	1987	In addition, endonexin II bound to phosphatidylserine- and phosphatidylethanolamine-containing liposomes in a Ca2+-dependent manner, and the binding was cooperative with respect to Ca2+ concentration (Hill constant greater than 3).	Phosphatidylserines	35-53	annexin A5	Homo sapiens	13-25
3111472-2	1987	Negatively charged lipids, sulfatide and phosphatidylserine (PS), lowered the Km values of t-PA for plasminogen activation (sulfatide, 20-fold; PS, 6-fold), whereas neutral lipid phosphatidylcholine raised the Km.	Phosphatidylserines	41-59	plasminogen activator, tissue type	Homo sapiens	91-95
3111472-2	1987	Negatively charged lipids, sulfatide and phosphatidylserine (PS), lowered the Km values of t-PA for plasminogen activation (sulfatide, 20-fold; PS, 6-fold), whereas neutral lipid phosphatidylcholine raised the Km.	Phosphatidylserines	61-63	plasminogen activator, tissue type	Homo sapiens	91-95
3038645-2	1987	Although phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine also increased insulin receptor autophosphorylation, only phosphatidylinositol (PtdIns) stimulated to a similar extent as the phospholipid mixture.	Phosphatidylserines	59-77	insulin receptor	Homo sapiens	93-109
3109905-4	1987	This GEF-dependent exchange is inhibited when Drosophila eIF-2 is either phosphorylated by the hemin-controlled inhibitor (HCI) of rabbit reticulocytes or treated with phosphatidylserine or a rabbit eIF-2 X phosphatidylserine complex.	Phosphatidylserines	168-186	Rho guanine nucleotide exchange factor at 64C	Drosophila melanogaster	5-8
3109905-4	1987	This GEF-dependent exchange is inhibited when Drosophila eIF-2 is either phosphorylated by the hemin-controlled inhibitor (HCI) of rabbit reticulocytes or treated with phosphatidylserine or a rabbit eIF-2 X phosphatidylserine complex.	Phosphatidylserines	168-186	eukaryotic translation initiation factor 2 subunit beta	Drosophila melanogaster	57-62
2953727-4	1987	These PMN proteins, like bovine liver synexin, promoted aggregation of isolated PMN specific granules in the presence of Ca2+ and increased the overall rate of Ca2+-induced fusion of liposomes composed of phosphatidate (PA)/phosphatidylethanolamine (PE) (1:3) and phosphatidylserine/PE (1:3), but decreased the rate of spermine-induced fusion of PA/PE (1:3) liposomes.	Phosphatidylserines	264-282	annexin A7	Bos taurus	38-45
3104321-3	1987	At pH values below about 5, TNF bound to phospholipid liposomes composed of mixtures of phosphatidyl-serine and phosphatidylcholine in molar ratios of 2:1 and 1:2 and caused rapid release of calcein.	Phosphatidylserines	88-107	tumor necrosis factor	Homo sapiens	28-31
3545832-6	1987	The conformation of des-Trp1-alpha-mating-factor [(2-13)peptide] in the membrane-bound state has been found to be similar to that of (1-13)peptide from the analysis of transferred nuclear Overhauser effects in the presence of mixed vesicles of perdeuterated phosphatidylcholine and perdeuterated phosphatidylserine.	Phosphatidylserines	296-314	phosphoribosylanthranilate isomerase TRP1	Saccharomyces cerevisiae S288C	24-28
3814599-4	1987	In contrast, the anti-HCR IgG has no effect on the inhibition produced by low levels of double-stranded RNA (that is due to the activation of a separate protein kinase), but it does partly reverse inhibition due to oxidized glutathione, ethanol, and phosphatidylserine, indicating that the effect of these components is mediated, at least in part, by the activation of HCR.	Phosphatidylserines	250-268	eukaryotic translation initiation factor 2-alpha kinase 1	Oryctolagus cuniculus	22-25
3029069-2	1987	Thrombomodulin was incorporated into vesicles ranging from neutral (100% phosphatidylcholine) to highly charged (30% phosphatidylserine and 70% phosphatidylcholine).	Phosphatidylserines	117-135	thrombomodulin	Oryctolagus cuniculus	0-14
3593300-3	1987	Membrane PL organization was detected by Bee venom phospholipase-A2 (Plase) treatment, which specifically hydrolyzes outer bilayer phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylcholine (PC).	Phosphatidylserines	131-149	phospholipase A2 group IB	Homo sapiens	51-67
3593300-3	1987	Membrane PL organization was detected by Bee venom phospholipase-A2 (Plase) treatment, which specifically hydrolyzes outer bilayer phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylcholine (PC).	Phosphatidylserines	151-153	phospholipase A2 group IB	Homo sapiens	51-67
3031455-2	1987	In this report a 2.8-kb subclone was shown to complement the ethanolamine-choline auxotrophy and to repair the defect in the synthesis of phosphatidylserine, both of which are characteristic of cho1 mutants.	Phosphatidylserines	138-156	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	194-198
3794793-8	1986	Purified protein F1 (Mr = 47,000, pI = 4.5) was found to be a hydrophilic molecule and was phosphorylated by 1000-fold purified PKC in the presence of phosphatidylserine (PS) and Ca2+.	Phosphatidylserines	151-169	growth associated protein 43	Homo sapiens	9-19
3794793-8	1986	Purified protein F1 (Mr = 47,000, pI = 4.5) was found to be a hydrophilic molecule and was phosphorylated by 1000-fold purified PKC in the presence of phosphatidylserine (PS) and Ca2+.	Phosphatidylserines	171-173	growth associated protein 43	Homo sapiens	9-19
3096987-9	1986	Unlike oleic acid, these detergents strongly inhibited protein kinase C activity induced by Ca2+/phosphatidylserine (PS) and diacylglycerol.	Phosphatidylserines	97-115	carbonic anhydrase 2	Homo sapiens	92-95
3019408-2	1986	Phosphatidylserine (0.1-1.0 mM) increased the signal intensity of the ESR spectrum of spin-labeled calmodulin and decreased the apparent rotational correlation time in the presence of 0.1 mM CaCl2.	Phosphatidylserines	0-18	calmodulin 1	Homo sapiens	99-109
3019408-9	1986	These findings indicate that spin-labeled calmodulin did not interact with the phospholipids by a hydrophobic interaction, but that calcium binding to spin-labeled calmodulin interfered with phosphatidic acid, phosphatidylserine, phosphatidylglycerol and phosphatidylinositol, and some of these phospholipids inactivated calmodulin.	Phosphatidylserines	210-228	calmodulin 1	Homo sapiens	164-174
3019408-9	1986	These findings indicate that spin-labeled calmodulin did not interact with the phospholipids by a hydrophobic interaction, but that calcium binding to spin-labeled calmodulin interfered with phosphatidic acid, phosphatidylserine, phosphatidylglycerol and phosphatidylinositol, and some of these phospholipids inactivated calmodulin.	Phosphatidylserines	210-228	calmodulin 1	Homo sapiens	164-174
3531198-8	1986	In the presence of 50 microM phospholipid vesicles (25% phosphatidylserine/75% phosphatidylcholine; mole/mole), the Km is 0.34 microM and the Vmax is 7.1 mumol of prothrombin activated per min/mg of venom.	Phosphatidylserines	56-74	coagulation factor II, thrombin	Bos taurus	163-174
3781738-3	1986	The binding of tritiated Leu-enkephalin to phosphatidylserine and phosphatidylcholine vesicles, both unmodified and modified by the incorporation of free fatty acid, has been studied by steric exclusion chromatography, ultraviolet difference spectroscopy and fluorescence anisotropy.	Phosphatidylserines	43-61	prodynorphin	Homo sapiens	25-39
3026338-3	1986	Reconstitution of thrombomodulin into phospholipid vesicles containing anionic phospholipids resulted in an increased rate of activation of protein C. Cardiolipin and vesicles containing phosphatidylcholine/phosphatidylserine (1:1, w/w) were the most effective.	Phosphatidylserines	207-225	thrombomodulin	Homo sapiens	18-32
3748456-2	1986	We have found the phospholipid, phosphatidylserine (PS) to be a highly specific inhibitor of MAO-B, which has led us to postulate that the PS-MAO interaction might offer a basis for the lower MAO levels observed in platelets from certain schizophrenic populations.	Phosphatidylserines	32-50	monoamine oxidase B	Homo sapiens	93-98
3748456-2	1986	We have found the phospholipid, phosphatidylserine (PS) to be a highly specific inhibitor of MAO-B, which has led us to postulate that the PS-MAO interaction might offer a basis for the lower MAO levels observed in platelets from certain schizophrenic populations.	Phosphatidylserines	52-54	monoamine oxidase B	Homo sapiens	93-98
3729937-1	1986	In a Triton X100-extract from the particulate fraction of mouse epidermis but also of other murine tissues, the phosphorylation of a protein with the relative molecular mass of 82,000 (p82) is found to be dependent on phosphatidyl serine and the tumor promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Phosphatidylserines	218-237	A kinase (PRKA) anchor protein 4	Mus musculus	185-188
3698022-1	1986	Phorbol esters trigger production of interleukin 2 by EL4 thymoma cells via an interaction with specific receptors, now considered to be identical with protein kinase C. Several in vitro substrates for protein kinase C were characterized by incubating cytosol from phorbol ester-responsive and -nonresponsive cells with [32P]adenosine triphosphate and CaCl2 with or without phosphatidylserine and diolein and separating proteins by gel electrophoresis.	Phosphatidylserines	374-392	interleukin 2	Mus musculus	37-50
3758663-1	1986	Tryptophanyl emission spectra of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase (G3PDH) were measured after the addition of liposomes prepared of natural phospholipids: phosphatidylinositols (PI), phosphatidylserines (PS) and phosphatidylcholines (PC).	Phosphatidylserines	205-224	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	89-94
3758663-1	1986	Tryptophanyl emission spectra of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase (G3PDH) were measured after the addition of liposomes prepared of natural phospholipids: phosphatidylinositols (PI), phosphatidylserines (PS) and phosphatidylcholines (PC).	Phosphatidylserines	226-228	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	89-94
3954363-8	1986	Alone or in the presence of the heat-stable factor, phosphatidylserine and phosphatidylinositol were the most effective activators of glucocerebrosidase.	Phosphatidylserines	52-70	glucosylceramidase beta	Rattus norvegicus	134-152
3942801-1	1986	Phosphatidylserine (PS) has recently been reported to be a specific inhibitor of B-type monoamine oxidase (MAO-B).	Phosphatidylserines	0-18	monoamine oxidase B	Homo sapiens	107-112
3942801-1	1986	Phosphatidylserine (PS) has recently been reported to be a specific inhibitor of B-type monoamine oxidase (MAO-B).	Phosphatidylserines	20-22	monoamine oxidase B	Homo sapiens	107-112
3942801-8	1986	The results were consistent with an in vivo role for PS as an allosteric regulator of platelet MAO-B.	Phosphatidylserines	53-55	monoamine oxidase B	Homo sapiens	95-100
3948295-1	1986	It is proposed that cells store calcium in the hydrogen belt of their membranes, on the cytoplasmic side, with the Ca2+ ion captive in cages formed by the phosphate and carbonyl oxygens of two acidic phospholipid molecules; for instance, phosphatidylinositol and phosphatidylserine.	Phosphatidylserines	263-281	carbonic anhydrase 2	Homo sapiens	115-118
3929257-6	1985	The stimulatory effect of TRH to increase 32Pi incorporation into phosphatidylinositol was decreased by phosphatidylserine.	Phosphatidylserines	104-122	thyrotropin releasing hormone	Rattus norvegicus	26-29
2413014-3	1985	Addition of phosphatidylethanolamine (PE) or phosphatidylserine to the reconstitution mixture restores high affinity LqTx binding with KD = 1.9 nM for PC/PE vesicles at -90 mV and 36 degrees C in sucrose-substituted medium.	Phosphatidylserines	45-63	procollagen C-endopeptidase enhancer	Rattus norvegicus	151-156
2990564-1	1985	The Ca2+ dependent incorporation of [14C]ethanolamine, L-[14C]serine and [14C]choline into phosphatidylethanolamine, phosphatidylserine and phosphatidylcholine, respectively, were investigated in membrane preparations from rat heart.	Phosphatidylserines	117-135	carbonic anhydrase 2	Rattus norvegicus	4-7
3925588-4	1985	For the activation of 0.25 microM prothrombin by factor Xa in the presence of 50 microM phospholipid (phosphatidylserine/phosphatidylcholine, 25/75; mol/mol) and 5 mM CaCl2 50% inhibition was obtained at 0.28 microM fragment 1 or fragment 1.2.	Phosphatidylserines	102-120	coagulation factor II, thrombin	Bos taurus	34-45
3838669-2	1985	In vesicles composed of 50%/50% or 60%/40% DPPC/PS, Zn2+ and Cd2+-induced fusion at concentrations considerably lower than were required for Ca2+-induced fusion.	Phosphatidylserines	48-50	CD2 molecule	Bos taurus	61-64
3838251-1	1985	The interaction of Al3+, Cd2+ and Mn2+ with phosphatidylserine-containing lipid vesicles was studied.	Phosphatidylserines	44-62	CD2 molecule	Homo sapiens	25-28
3155739-5	1985	Phosphatidylserine-enriched vesicles (70% phosphatidylserine, 30% phosphatidylcholine) incorporated approximately 90% of the GP IIb-IIIa as determined by sucrose flotation.	Phosphatidylserines	0-18	integrin subunit alpha 2b	Homo sapiens	125-131
3155927-9	1985	Mixtures of phosphatidylserine and phosphatidylcholine produced intermediate ATPase activities, with the maximal value dependent on the phosphatidylserine concentration.	Phosphatidylserines	12-30	dynein axonemal heavy chain 8	Homo sapiens	77-83
3914834-3	1985	Upon stimulation of platelets with a combination of collagen and thrombin, or calcium ionophore A23187 or treatment with diamide, alterations in the distribution of membrane phospholipids take place resulting in the exposure of significant amounts of phosphatidylserine at the platelet surface.	Phosphatidylserines	251-269	coagulation factor II, thrombin	Homo sapiens	65-73
20492946-4	1985	Myelin basic protein can link liposomes composed of phosphatidyl serine; phosphatidyl serine + cholesterol; phosphatidyl serine + cholesterol + cerebroside sulphate.	Phosphatidylserines	52-71	myelin basic protein	Bos taurus	0-20
20492946-4	1985	Myelin basic protein can link liposomes composed of phosphatidyl serine; phosphatidyl serine + cholesterol; phosphatidyl serine + cholesterol + cerebroside sulphate.	Phosphatidylserines	73-92	myelin basic protein	Bos taurus	0-20
20492946-4	1985	Myelin basic protein can link liposomes composed of phosphatidyl serine; phosphatidyl serine + cholesterol; phosphatidyl serine + cholesterol + cerebroside sulphate.	Phosphatidylserines	73-92	myelin basic protein	Bos taurus	0-20
3993183-4	1985	Arrhenius plots of AchE activities in untreated SPM (control), exhibited a break point at 23 degrees C, which was decreased to 16-17 degrees C in PS-treated SPM.	Phosphatidylserines	146-148	acetylcholinesterase (Cartwright blood group)	Homo sapiens	19-23
6240267-4	1984	In the presence of 1 microM Ca2+, a mixture of phosphatidylserine and diolein (or a potent tumor promoter phorbol ester) was required for optimal cytochrome P-450scc phosphorylation.	Phosphatidylserines	47-65	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	146-165
6091744-6	1984	During the incubation, a small fraction of the spin-labels is hydrolyzed, particularly the phosphatidylserine derivative, presumably by an endogenous phospholipase A2.	Phosphatidylserines	91-109	phospholipase A2 group IB	Homo sapiens	150-166
6433504-2	1984	The addition of phospholipid vesicles containing phosphatidylserine and phosphatidylethanolamine to normal plasma and that of patients with von Willebrand"s disease resulted in the loss of almost two thirds of the factor VIII clotting antigen (VIII:CAg) measurable by IRMA.	Phosphatidylserines	49-67	cytochrome c oxidase subunit 8A	Homo sapiens	221-225
6373768-2	1984	Subsequent treatment with physiological concentrations of insulin provoked 40-70% increases in 32PO4 levels (reflecting increases in mass) in phosphatidic acid, phosphatidylinositol, and polyphosphoinositides, and, lesser, 20-25% increases in phosphatidylserine and the combined chromatographic area containing phosphatidylethanolamine plus phosphatidylcholine plus phosphatidylcholine.	Phosphatidylserines	243-261	insulin	Homo sapiens	58-65
6587389-1	1984	Spin-labeled analogs of phosphatidylcholine, phosphatidylserine, and phosphatidylethanolamine have been used to study phospholipid transverse diffusion and asymmetry in the human erythrocyte membrane.	Phosphatidylserines	45-63	spindlin 1	Homo sapiens	0-4
6724805-2	1984	Interaction of Leu- and Met-enkephalin with phosphatidylserine has been studied by chromatographic and spectrophotometric techniques.	Phosphatidylserines	44-62	proopiomelanocortin	Homo sapiens	24-38
6706963-2	1984	The present study reports the effect of malonyldialdehyde (MDA), a product of fatty acid peroxidation, on the organization of phosphatidylserine (PS) and phosphatidylethanolamine (PE) in human erythrocytes using a nonpermeable bee venom phospholipase A2 and trinitrobenzene-sulfonilic acid.	Phosphatidylserines	126-144	phospholipase A2 group IB	Homo sapiens	237-253
6706963-2	1984	The present study reports the effect of malonyldialdehyde (MDA), a product of fatty acid peroxidation, on the organization of phosphatidylserine (PS) and phosphatidylethanolamine (PE) in human erythrocytes using a nonpermeable bee venom phospholipase A2 and trinitrobenzene-sulfonilic acid.	Phosphatidylserines	146-148	phospholipase A2 group IB	Homo sapiens	237-253
6433935-3	1984	Thyrotropin-releasing hormone (TRH), which is known to enhance locomotion of animals, also enhanced the rate of PS synthesis to compensate for the genetic defect in the rate of PS synthesis in vitro.	Phosphatidylserines	112-114	thyrotropin releasing hormone	Mus musculus	0-29
6433935-3	1984	Thyrotropin-releasing hormone (TRH), which is known to enhance locomotion of animals, also enhanced the rate of PS synthesis to compensate for the genetic defect in the rate of PS synthesis in vitro.	Phosphatidylserines	177-179	thyrotropin releasing hormone	Mus musculus	0-29
6733153-0	1984	Interaction of alpha-thrombin and prethrombin 2, with phosphatidylserine-containing monolayers.	Phosphatidylserines	54-72	coagulation factor II, thrombin	Homo sapiens	21-29
6361126-5	1984	These studies indicate that by using vesicles composed of 50% phosphatidylethanolamine/50% phosphatidylserine it is possible to introduce into the mouse EL4 cell surface about 70% of the amount of HLA expressed normally on the human lymphoblastoid line JY.	Phosphatidylserines	91-109	epilepsy 4	Mus musculus	153-156
6417142-10	1983	3H-labeled vinculin binds to phosphatidylserine, phosphatidylinositol, phosphatidylglycerol, and phosphatidic acid.	Phosphatidylserines	29-47	vinculin	Homo sapiens	11-19
6651881-0	1983	Investigations of the mechanism of selective inhibition of type B mitochondrial monoamine oxidase by phosphatidylserine.	Phosphatidylserines	101-119	monoamine oxidase A	Rattus norvegicus	80-97
6651881-6	1983	These results suggest a specific interaction between MAO and PS rather than an indirect effect of bulk changes in membrane properties, but an intact membrane was, nevertheless, required to mediate the inhibition.	Phosphatidylserines	61-63	monoamine oxidase A	Rattus norvegicus	53-56
6651881-8	1983	Lineweaver-Burk plots of the effect of PS incorporation into bovine liver mitochondrial membranes on MAO oxidation of phenylethylamine exhibited the expected pattern for a noncompetitive inhibitor acting on a ping-pong mechanism bireactant enzyme.	Phosphatidylserines	39-41	monoamine oxidase A	Rattus norvegicus	101-104
6139416-2	1983	The phospholipase A2 stimulation, dependent on calcium, was elicited in resting synaptosomes by A23187 and was demonstrated with incorporated 1-acyl-2-[14C]oleoyl-phosphatidylcholine but not with incorporated [14C]phosphatidylethanolamine or [14C]phosphatidylserine.	Phosphatidylserines	247-265	phospholipase A2 group IB	Rattus norvegicus	4-20
6225775-4	1983	Both calcium and phosphatidylserine were required for vinculin phosphorylation by protein kinase C. In addition, both phorbol 12,13-dibutyrate (10 nM) and phorbol 12-myristate 13-acetate (10 nM) stimulated vinculin phosphorylation by protein kinase C at a limiting calcium concentration (10(-6) M).	Phosphatidylserines	17-35	vinculin	Homo sapiens	54-62
6225775-4	1983	Both calcium and phosphatidylserine were required for vinculin phosphorylation by protein kinase C. In addition, both phorbol 12,13-dibutyrate (10 nM) and phorbol 12-myristate 13-acetate (10 nM) stimulated vinculin phosphorylation by protein kinase C at a limiting calcium concentration (10(-6) M).	Phosphatidylserines	17-35	vinculin	Homo sapiens	206-214
6191774-3	1983	At pH 7.5, lysozyme, cytochrome c, poly(L-lysine) and ribonuclease were shown to increase the chemical shift anisotropy of PS by between 12-20%.	Phosphatidylserines	123-125	lysozyme C, tracheal isozyme	Bos taurus	11-19
6191774-3	1983	At pH 7.5, lysozyme, cytochrome c, poly(L-lysine) and ribonuclease were shown to increase the chemical shift anisotropy of PS by between 12-20%.	Phosphatidylserines	123-125	LOC104968582	Bos taurus	21-33
6615435-4	1983	1, 12-Diaminododecane, in comparison, inhibited the phospholipid-sensitive enzyme competitively with respect to Ca2+ (Ki = 0.45 mM) and phosphatidylserine (Ki = 0.50 mM); it also inhibited myosin light-chain kinase competitively with respect to calmodulin (Ki = 0.63 mM) but non-competitively with respect to Ca2+ (Ki = 1.49 mM).	Phosphatidylserines	136-154	myosin light chain kinase	Rattus norvegicus	189-214
6615435-4	1983	1, 12-Diaminododecane, in comparison, inhibited the phospholipid-sensitive enzyme competitively with respect to Ca2+ (Ki = 0.45 mM) and phosphatidylserine (Ki = 0.50 mM); it also inhibited myosin light-chain kinase competitively with respect to calmodulin (Ki = 0.63 mM) but non-competitively with respect to Ca2+ (Ki = 1.49 mM).	Phosphatidylserines	136-154	calmodulin 1	Rattus norvegicus	245-255
6882441-1	1983	Key kinetic parameters for the prothrombinase complex formed on membranes of phosphatidylserine (PS)/phosphatidylcholine (PC) (40/60) (Km = 0.12 microM, kcat = 11 s-1) or PS/PC (2/98) (Km = 0.40 microM, kcat = 11 s-1) differed only slightly.	Phosphatidylserines	77-95	coagulation factor X	Homo sapiens	31-45
6882441-1	1983	Key kinetic parameters for the prothrombinase complex formed on membranes of phosphatidylserine (PS)/phosphatidylcholine (PC) (40/60) (Km = 0.12 microM, kcat = 11 s-1) or PS/PC (2/98) (Km = 0.40 microM, kcat = 11 s-1) differed only slightly.	Phosphatidylserines	97-99	coagulation factor X	Homo sapiens	31-45
6623990-0	1983	[Effect of phosphatidyl serine on conversion of fibrinogen to fibrin].	Phosphatidylserines	11-30	fibrinogen beta chain	Homo sapiens	48-58
6623990-1	1983	Phosphatidyl serine inhibited the conversion of fibrinogen into fibrin, catalyzed by thrombin, following the pattern of coupling inhibition.	Phosphatidylserines	0-19	fibrinogen beta chain	Homo sapiens	48-58
6623990-1	1983	Phosphatidyl serine inhibited the conversion of fibrinogen into fibrin, catalyzed by thrombin, following the pattern of coupling inhibition.	Phosphatidylserines	0-19	coagulation factor II, thrombin	Homo sapiens	85-93
6623990-2	1983	The inhibition was caused by the property of phosphatidyl serine of forming an exhibiting low activity complex with thrombin as well as by interaction of the lipoid with monomeric fibrin; as a result of this process phosphatidyl serine inhibited both enzymatic and non-enzymatic pathways of the fibrin formation.	Phosphatidylserines	45-64	coagulation factor II, thrombin	Homo sapiens	116-124
6623990-3	1983	Administration of phosphatidyl serine into animal circulation led to a decrease in fibrinogen consumption, provoked by simultaneous injection of thrombin.	Phosphatidylserines	18-37	fibrinogen beta chain	Homo sapiens	83-93
6623990-3	1983	Administration of phosphatidyl serine into animal circulation led to a decrease in fibrinogen consumption, provoked by simultaneous injection of thrombin.	Phosphatidylserines	18-37	coagulation factor II, thrombin	Homo sapiens	145-153
6337878-2	1983	It was observed that cdc28 cells which are known to arrest at "start" when shifted to their non-permissive temperature, resulted in a 40% decrease in phosphatidylinositol (PI) level while the phosphatidylserine (PS) content was doubled in these cells.	Phosphatidylserines	192-210	cyclin-dependent serine/threonine-protein kinase CDC28	Saccharomyces cerevisiae S288C	21-26
6337878-2	1983	It was observed that cdc28 cells which are known to arrest at "start" when shifted to their non-permissive temperature, resulted in a 40% decrease in phosphatidylinositol (PI) level while the phosphatidylserine (PS) content was doubled in these cells.	Phosphatidylserines	212-214	cyclin-dependent serine/threonine-protein kinase CDC28	Saccharomyces cerevisiae S288C	21-26
6337878-4	1983	The increase in PS level in cdc28 mutant which was probably to compensate the intrinsic charging of membrane environment, was also reduced in cdc4 and cdc7 mutants.	Phosphatidylserines	16-18	cyclin-dependent serine/threonine-protein kinase CDC28	Saccharomyces cerevisiae S288C	28-33
6337878-4	1983	The increase in PS level in cdc28 mutant which was probably to compensate the intrinsic charging of membrane environment, was also reduced in cdc4 and cdc7 mutants.	Phosphatidylserines	16-18	SCF ubiquitin ligase complex subunit CDC4	Saccharomyces cerevisiae S288C	142-146
6337878-4	1983	The increase in PS level in cdc28 mutant which was probably to compensate the intrinsic charging of membrane environment, was also reduced in cdc4 and cdc7 mutants.	Phosphatidylserines	16-18	serine/threonine protein kinase CDC7	Saccharomyces cerevisiae S288C	151-155
6838561-2	1983	Phosphatidic acid, phosphatidyl ethanolamine, phosphatidyl serine, phosphatidyl inositol, phosphatidyl glycerol and cardiolipin were found to activate greatly the cathepsin D.	Phosphatidylserines	46-65	cathepsin D	Homo sapiens	163-174
6297895-1	1983	Interactions of band 4.1 with mixed phospholipid membranes [phosphatidylserine (PtdSer), phosphatidylethanolamine, phosphatidylcholine, etc.]	Phosphatidylserines	60-78	erythrocyte membrane protein band 4.1	Homo sapiens	16-24
6298074-6	1983	Phospholipase C from B. cereus reduced the content of phosphatidylserine, while the enzyme from C. welchii did not.	Phosphatidylserines	54-72	LOC100009319	Oryctolagus cuniculus	0-15
6299276-1	1982	Oleic acid, phosphatidylserine and pyrenedecanoic acid were found to activate calmodulin-deficient cyclic nucleotide phosphodiesterase at concentrations above their critical micellar concentration.	Phosphatidylserines	12-30	calmodulin 1	Homo sapiens	78-88
7160029-6	1982	In contrast to these two proteins, the presence of synexin in the solution did enhance the Ca2+-induced aggregation of phosphatidylserine vesicles, but did not seem to affect the degree of Ca2+-induced fusion between phosphatidylserine/phosphatidylcholine (1:1) and phosphatidylserine vesicles and monolayer membranes.	Phosphatidylserines	119-137	annexin A7	Homo sapiens	51-58
6897280-7	1982	These results suggest that naphthalenesulfonamide derivatives may be more selective inhibitors of Ca2+, calmodulin-dependent protein phosphorylation than is Ca2+-activated, phospholipid-dependent protein kinase and that the mechanism of interaction between W-7 and phosphatidylserine differs from the interaction between W-7 and calmodulin.	Phosphatidylserines	265-283	calmodulin 1	Homo sapiens	104-114
6214785-3	1982	Synexin facilitated Ca2+-mediated, but not Mg2+-mediated, fusion of phosphatidate/phosphatidylethanolamine (1:3) and phosphatidate/phosphatidylserine/phosphatidylethanolamine/cholesterol (1:2:3:2) vesicles.	Phosphatidylserines	131-149	annexin A7	Homo sapiens	0-7
6177222-2	1982	Washed peritoneal mast cells suspended in a physiological medium containing bovine serum albumin require ten-fold higher concentrations of phosphatidyl serine for optimal release by concanavalin A.	Phosphatidylserines	139-158	albumin	Rattus norvegicus	83-96
7066318-8	1982	Thus, it was concluded that F- enhanced the interaction between Ca2+ and phosphatidylserine, possibly by forming a phosphatidylserine-Ca-F complex.	Phosphatidylserines	73-91	carbonic anhydrase 2	Homo sapiens	64-67
6176268-0	1982	Rat mast cell phospholipase A2: activity toward exogenous phosphatidylserine and inhibiton by N-(7-nitro-2,1,3-benzoxadiazol-4-yl)phosphatidylserine.	Phosphatidylserines	58-76	phospholipase A2 group IB	Rattus norvegicus	14-30
6176268-1	1982	The presence of phospholipase A2 in intact rat peritoneal mast cells was investigated by using two synthetic radiolabeled phosphatidylserine (PS) substrates.	Phosphatidylserines	122-140	phospholipase A2 group IB	Rattus norvegicus	16-32
6176268-6	1982	Over the concentration range at which exogenous PS activates mast cell secretion, intact mast cells and broken cells possessed nearly equal levels of phospholipase A2 activity, and enzyme activity was 3--4-fold higher toward PS than phosphatidylcholine.	Phosphatidylserines	48-50	phospholipase A2 group IB	Rattus norvegicus	150-166
6176268-8	1982	Of the agents tested, an N-substituted derivative of PS previously identified as an inhibitor of mast cell secretion was shown to be a particularly potent and efficacious inhibitor of mast cell phospholipase A2.	Phosphatidylserines	53-55	phospholipase A2 group IB	Rattus norvegicus	194-210
7060571-2	1982	Platelet prothrombin-converting activity only decreased after treatment with those phospholipases which are able to hydrolyse phospholipids in the intact platelet and also have the ability to degrade negatively charged phospholipids, phosphatidylserine and phosphatidylinositol.	Phosphatidylserines	234-252	coagulation factor II, thrombin	Homo sapiens	9-20
7060571-5	1982	It is concluded that negatively charged phosphatidylserine and possibly phosphatidylinositol are involved in the prothrombin-converting activity of non-activated platelets.	Phosphatidylserines	40-58	coagulation factor II, thrombin	Homo sapiens	113-124
7087686-3	1982	In the second series of experiments, the purified phospholipase A2 showed preferential action toward PI (100%) compared to phosphatidylcholine (PC, 62.5%), phosphatidic acid (PA, 32.6%), phosphatidylethanolamine (PE, 25.1%) and phosphatidylserine (PS, 21.5%), where each phosphoglyceride was  labeled in the 2-position with [1-14C] oleic acid.	Phosphatidylserines	228-246	LOC104974671	Bos taurus	50-66
7087686-3	1982	In the second series of experiments, the purified phospholipase A2 showed preferential action toward PI (100%) compared to phosphatidylcholine (PC, 62.5%), phosphatidic acid (PA, 32.6%), phosphatidylethanolamine (PE, 25.1%) and phosphatidylserine (PS, 21.5%), where each phosphoglyceride was  labeled in the 2-position with [1-14C] oleic acid.	Phosphatidylserines	248-250	LOC104974671	Bos taurus	50-66
6796129-2	1981	The binding of factor VIII to an equimolecular mixture of phosphatidylserine (PS) and phosphatidylcholine (PC) was studied by sucrose gradient ultracentrifugation (10-40% w/v saccharose in  0.01 M Tris-HC1/0.15 M NaCl buffer (pH 7).	Phosphatidylserines	58-76	cytochrome c oxidase subunit 8A	Homo sapiens	22-26
6796129-2	1981	The binding of factor VIII to an equimolecular mixture of phosphatidylserine (PS) and phosphatidylcholine (PC) was studied by sucrose gradient ultracentrifugation (10-40% w/v saccharose in  0.01 M Tris-HC1/0.15 M NaCl buffer (pH 7).	Phosphatidylserines	78-80	cytochrome c oxidase subunit 8A	Homo sapiens	22-26
7324188-2	1981	Evidently, phosphatidyl serine inhibits only the second stage of thrombinogenesis--the interaction of factor Xa with prothrombin, and does not affect the activation of factor X.	Phosphatidylserines	11-30	coagulation factor X	Homo sapiens	102-111
7324188-2	1981	Evidently, phosphatidyl serine inhibits only the second stage of thrombinogenesis--the interaction of factor Xa with prothrombin, and does not affect the activation of factor X.	Phosphatidylserines	11-30	coagulation factor II, thrombin	Homo sapiens	117-128
7324188-4	1981	Therefore, the interaction of factor Xa-prothrombin realized due to appearance of the phosphatidyl serine-prothrombin low-active complex is the only object of the inhibitory effect of phosphatidyl serine on thrombogenesis.	Phosphatidylserines	86-105	coagulation factor X	Homo sapiens	30-39
7324188-4	1981	Therefore, the interaction of factor Xa-prothrombin realized due to appearance of the phosphatidyl serine-prothrombin low-active complex is the only object of the inhibitory effect of phosphatidyl serine on thrombogenesis.	Phosphatidylserines	86-105	coagulation factor II, thrombin	Homo sapiens	40-51
7324188-4	1981	Therefore, the interaction of factor Xa-prothrombin realized due to appearance of the phosphatidyl serine-prothrombin low-active complex is the only object of the inhibitory effect of phosphatidyl serine on thrombogenesis.	Phosphatidylserines	86-105	coagulation factor II, thrombin	Homo sapiens	106-117
7314577-2	1981	Phosphatidyl serine inhibited formation of thrombin in the prothrombin complex, activated by tissue thromboplastin or factor Xa in presence of Ca2+ in vitro.	Phosphatidylserines	0-19	coagulation factor II, thrombin	Homo sapiens	43-51
7314577-2	1981	Phosphatidyl serine inhibited formation of thrombin in the prothrombin complex, activated by tissue thromboplastin or factor Xa in presence of Ca2+ in vitro.	Phosphatidylserines	0-19	coagulation factor X	Homo sapiens	118-127
7314577-4	1981	Phosphatidyl serine inhibited also the effect of factor Xa on synthetic substrate BAME, interacting with the latter; these data were corroborated by study of absorbance spectra of phosphatidyl serine, BAME and their mixture.	Phosphatidylserines	0-19	coagulation factor X	Homo sapiens	49-58
7314577-4	1981	Phosphatidyl serine inhibited also the effect of factor Xa on synthetic substrate BAME, interacting with the latter; these data were corroborated by study of absorbance spectra of phosphatidyl serine, BAME and their mixture.	Phosphatidylserines	180-199	coagulation factor X	Homo sapiens	49-58
6455424-5	1981	A variety of acidic phospholipids (phosphatidylserine, cardiolipin, phosphatidylinositol, and phosphatidic acid) stimulate the Vmax and decrease the Km (Ca2+) of the isolated enzyme to the same extent as calmodulin.	Phosphatidylserines	35-53	calmodulin 1	Homo sapiens	204-214
7016857-4	1981	Acrosin was observed to bind to liposomes containing acidic phospholipids such as phosphatidylglycerol, cardiolipin, and phosphatidylserine.	Phosphatidylserines	121-139	acrosin	Homo sapiens	0-7
6452452-5	1981	Synexin lowers the threshold of CA2+ concentration required for fusion of large unilamellar vesicles of phosphatidylserine and a mixture of phosphatidylserine with phosphatidylethanolamine.	Phosphatidylserines	104-122	annexin A7	Homo sapiens	0-7
6452452-5	1981	Synexin lowers the threshold of CA2+ concentration required for fusion of large unilamellar vesicles of phosphatidylserine and a mixture of phosphatidylserine with phosphatidylethanolamine.	Phosphatidylserines	104-122	carbonic anhydrase 2	Homo sapiens	32-35
6452452-10	1981	With vesicles containing a mixture of phosphatidylserine with phosphatidylcholine, synexin enhances aggregation in the presence of CA2+, without promoting fusion.	Phosphatidylserines	38-56	annexin A7	Homo sapiens	83-90
7225377-11	1981	Mg2+ had a synergistic effect on Ca2+-induced fusion of phosphatidylserine/phosphatidylethanolamine vesicles.	Phosphatidylserines	56-74	mucin 7, secreted	Homo sapiens	0-3
6894279-1	1981	Phosphatidylcholine and phosphatidylserine + phosphatidylcholine liposomes were prepared with cholate and erythrocyte acetylcholinesterase (EC 3.1.1.7).	Phosphatidylserines	24-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	118-138
7430120-10	1980	The preferred substrates for platelet phospholipase A2 appear to be phosphatidylethanolamine, phosphatidylcholine, and phosphatidylserine, while phosphatidylinositol seems to be degraded nearly exclusively by phospholipase C.	Phosphatidylserines	119-137	phospholipase A2	Equus caballus	38-54
6771275-1	1980	Phospholipid biosynthesis in a mutant of Saccharomyces cerevisiae (cho1) which lacks phosphatidylserine (Atkinson, K. D., Jensen, B., Storm, E., Kolat, A. I., Henry, S. A.	Phosphatidylserines	85-103	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	67-71
6771275-5	1980	While all phospholipid biosynthetic activities, except phosphatidylserine synthesis, can be demonstrated in vitro in the cho1 mutant, the entire pattern of phospholipid synthesis, accumulation, and turnover in vivo is distorted.	Phosphatidylserines	55-73	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	121-125
7407052-3	1980	The adsorption isotherms of prothrombin and its fragment I on phosphatidylserine monolayers and on mixed monolayers of phosphatidylcholine and phosphatidylserine were determined by measuring surface radioactivity emanating from the tritium-labeled absorbed proteins at 0.1 N NaCl and between 0 and 10 mM Ca2+.	Phosphatidylserines	62-80	coagulation factor II, thrombin	Homo sapiens	28-39
7364757-5	1980	On the other hand, SPF was shown to bind tightly to vesicles of anionic phospholipids (phosphatidylglycerol, phosphatidylserine, phosphatidylinositol, and phosphatidic acid) but not to vesicles of phosphatidylcholine or phosphatidylethanolamine.	Phosphatidylserines	109-127	SEC14 like lipid binding 2	Homo sapiens	19-22
226973-1	1979	Human beta-endorphin adopts a partial helical conformation in aqueous solutions of cerebroside sulfate, ganglioside GM1, phosphatidylserine, and phosphatidic acid, but not of cerebroside and phosphatidylcholine, as evidenced by circular dichroic spectra.	Phosphatidylserines	121-139	proopiomelanocortin	Homo sapiens	6-20
223675-3	1979	It was demonstrated that the glucose-6-phosphate phosphohydrolase activity of glucose-6-phosphatase depends on the content of phosphatidylethanolamine in the microsomal membranes, whereas the inorganic pyrophosphate phosphohydrolase activity seems to be dependent on the phosphatidylserine content.	Phosphatidylserines	271-289	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	78-99
38406-4	1979	The binding of SP to phosphatidyl serine, phosphatidyl ethanolamine and phosphatidyl inositol was lowest at pH 2 and increased with pH.	Phosphatidylserines	21-40	tachykinin precursor 1	Homo sapiens	15-17
38406-9	1979	The high affinity (KD = 0.1 microM) and capacity of 44 pmol SP/microgram phosphatidyl serine and 48 pmol SP/microgram phosphatidyl ethanolamine at pH 7.2 under conditions of saturation contrasted with the very low binding of SP to phosphatidyl inositol or phosphatidyl choline.	Phosphatidylserines	73-92	tachykinin precursor 1	Homo sapiens	60-62
38406-12	1979	There was a concentration-dependent reduction in the binding of SP to phosphatidyl serine or phosphatidyl ethanolamine by Na+ and Ca2+, whereas K+ showed hardly any effect at physiological concentrations.	Phosphatidylserines	70-89	tachykinin precursor 1	Homo sapiens	64-66
517012-4	1979	The acidic phospholipids, phosphatidylserine and phosphatidylinositol and total microsomal phospholipids containing the acidic lipid components activate cytochrome P-450 in the hydroxylation of aniline and naphthalene by CHP.	Phosphatidylserines	26-44	cytochrome P-450	Oryctolagus cuniculus	153-169
503305-2	1979	On the other hand, liposomes obtained from bovine brain cortex phospholipids reduced serum prolactin possibly through an effect of phosphatidylserine on dopamine biosynthesis at the level of tyrosine hydroxylase.	Phosphatidylserines	131-149	prolactin	Bos taurus	91-100
738993-2	1978	Phospholipase A1 in FL cell cytosol showed activity only in the presence of a non-ionic detergent, Triton X-100, or certain phospholipids such as phosphatidylinositol, cardiolipin,  phosphatidylserine, phosphatidic acid, phosphatidylethanolamine, and lysophosphatidylcholine, among which phosphatidylinositol was the most active stimulator of the activity.	Phosphatidylserines	182-200	lipase H	Homo sapiens	0-16
360047-2	1978	Sphingomyelin, phosphatidylserine, bovine lecithin and phosphatidylethanolamine modify the thermal stabilization of H2B-DNA complexes, by inducing stabilization at 0.3 and 0.6 H2B : DNA weight ratios and destabilify the arrangement of nucleohistone is confirmed by ultrastructural analysis which indicates a competitive action of these molecules during the nucleoprotein assembly.	Phosphatidylserines	15-33	histone H2B type 2-E	Bos taurus	116-119
360047-2	1978	Sphingomyelin, phosphatidylserine, bovine lecithin and phosphatidylethanolamine modify the thermal stabilization of H2B-DNA complexes, by inducing stabilization at 0.3 and 0.6 H2B : DNA weight ratios and destabilify the arrangement of nucleohistone is confirmed by ultrastructural analysis which indicates a competitive action of these molecules during the nucleoprotein assembly.	Phosphatidylserines	15-33	histone H2B type 2-E	Bos taurus	176-179
150701-5	1978	The data obtained support the earlier advanced assumptions on inhibition of thrombin-fibrinogene reaction by phosphatidyl serine.	Phosphatidylserines	109-128	coagulation factor II, thrombin	Homo sapiens	76-84
577185-1	1977	Differential scanning calorimetry (DSC) was used to detect phase separation induced by hydrophobic myelin protein, lipophilin, in a mixture of phosphatidylserine (PS) and dipalmitoylphosphatidylcholine (DPPC).	Phosphatidylserines	143-161	proteolipid protein 1	Homo sapiens	115-125
577185-1	1977	Differential scanning calorimetry (DSC) was used to detect phase separation induced by hydrophobic myelin protein, lipophilin, in a mixture of phosphatidylserine (PS) and dipalmitoylphosphatidylcholine (DPPC).	Phosphatidylserines	163-165	proteolipid protein 1	Homo sapiens	115-125
577185-2	1977	Preferential binding of PS to the boundary layer of lipophilin causes a decrease in the PS content of the remaining lamellar phase with a resultant shift in the phase-transition temperature to a higher temperature.	Phosphatidylserines	24-26	proteolipid protein 1	Homo sapiens	52-62
577185-2	1977	Preferential binding of PS to the boundary layer of lipophilin causes a decrease in the PS content of the remaining lamellar phase with a resultant shift in the phase-transition temperature to a higher temperature.	Phosphatidylserines	88-90	proteolipid protein 1	Homo sapiens	52-62
577185-5	1977	In the case where partial phase separation in induced in this mixture by Ca2+ alone, lipophilin increases the phase separation indicating that it also binds PS preferentially in the presence of Ca2+.	Phosphatidylserines	157-159	proteolipid protein 1	Homo sapiens	85-95
190241-6	1977	Phospholipase A treatment of intact microsomes in the presence of albumin hydrolyzed all of the phosphatidylethanolamine, phosphatidylserine, and 55% of the phosphatidylcholine.	Phosphatidylserines	122-140	phospholipase A and acyltransferase 1	Homo sapiens	0-15
1022277-1	1976	A possibility of formation of the thrombin-phosphatidyl serine and prothrombin-phosphatidyl serine complex is discussed.	Phosphatidylserines	43-62	coagulation factor II, thrombin	Homo sapiens	34-42
1022277-2	1976	Prothrombin incubation with 131J-labelled phosphatidyl serine and its subsequent activation results in a formation of a thrombin-phosphatidyl serine--131J-complex.	Phosphatidylserines	42-61	coagulation factor II, thrombin	Homo sapiens	3-11
1022277-3	1976	The radioactive label is also detected in the protein precipitate after thermodenaturation of thrombin preincubated with 131J-labelled phosphatidyl serine, which suggests that thrombin is firmly bound to phosphatidyl serine.	Phosphatidylserines	135-154	coagulation factor II, thrombin	Homo sapiens	94-102
1022277-3	1976	The radioactive label is also detected in the protein precipitate after thermodenaturation of thrombin preincubated with 131J-labelled phosphatidyl serine, which suggests that thrombin is firmly bound to phosphatidyl serine.	Phosphatidylserines	135-154	coagulation factor II, thrombin	Homo sapiens	176-184
1022277-3	1976	The radioactive label is also detected in the protein precipitate after thermodenaturation of thrombin preincubated with 131J-labelled phosphatidyl serine, which suggests that thrombin is firmly bound to phosphatidyl serine.	Phosphatidylserines	204-223	coagulation factor II, thrombin	Homo sapiens	94-102
1022277-3	1976	The radioactive label is also detected in the protein precipitate after thermodenaturation of thrombin preincubated with 131J-labelled phosphatidyl serine, which suggests that thrombin is firmly bound to phosphatidyl serine.	Phosphatidylserines	204-223	coagulation factor II, thrombin	Homo sapiens	176-184
1022277-4	1976	The formation of the thrombin-phosphatidyl serine and prothrombin-phosphatidyl serine complex is supported by data of gel-filtration on Sephadex G-200 and acrylexes P-150 and P-60, as well as by differential spectrophotometry.	Phosphatidylserines	30-49	coagulation factor II, thrombin	Homo sapiens	21-29
1022277-4	1976	The formation of the thrombin-phosphatidyl serine and prothrombin-phosphatidyl serine complex is supported by data of gel-filtration on Sephadex G-200 and acrylexes P-150 and P-60, as well as by differential spectrophotometry.	Phosphatidylserines	30-49	interferon induced protein with tetratricopeptide repeats 3	Homo sapiens	136-179
187172-4	1976	Analysis of the myelin pellet obtained after centrifugation of the myelin sample incubated with snake venom or phospholipase A alone showed conversion of phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine into their corresponding lyso compounds.	Phosphatidylserines	204-222	phospholipase A and acyltransferase 1	Homo sapiens	111-126
986183-1	1976	An equimolar mixture of phosphatidylserine and (dioleoyl) phosphatidyl-ethanolamine could substitute for brain cephalin preparations in the single stage prothrombin assay.	Phosphatidylserines	24-42	coagulation factor II, thrombin	Bos taurus	153-164
986183-5	1976	In the presence of 25 mM Ca2+, dioleoylphosphatidic acid or brain phosphatidylserine alone, and with other long chain phospholipids, formed complexes with bovine plasma prothrombin.	Phosphatidylserines	66-84	coagulation factor II, thrombin	Bos taurus	169-180
4122-2	1976	The activity of a partially purified preparation of tyrosine hydroxylase (EC 1.14.16.2) from the bovine caudate nucleus was increased by heparin, chondroitin sulfate, phosphatidylserine, polyacrylic acid, polyvinyl sulfuric acid and both poly-D-, and poly-L-glutamic acids, all polyanions.	Phosphatidylserines	167-185	tyrosine hydroxylase	Bos taurus	52-72
1276287-3	1976	In isolated hemocoagulating systems LA and phosphatidyl serine were shown to inhibit prothrombin conversion catalyzed by thrombokinase and to exert the antithrombic action in the system thrombin--fibrinogen.	Phosphatidylserines	43-62	coagulation factor II, thrombin	Homo sapiens	88-96
1009570-3	1976	The results with erythrocyte ghosts show that at 50 muM probe 31-50% of the total phosphatidylethanolamine is cross-linked to itself and 10-12% of the phosphatidylethanolamine is cross-linked to phosphatidylserine.	Phosphatidylserines	195-213	latexin	Homo sapiens	52-55
805602-1	1975	Freeze-fracture electron microscopy was used to study the morphological changes occurring following the addition of Ca-2+ to sonicated preparations of phosphatidylserine in aqueous NaCl buffer.	Phosphatidylserines	151-169	carbonic anhydrase 2	Homo sapiens	116-120
33740632-5	2021	Using the HMSC-NH2-PLD, a high-efficient method for the conversion of phosphatidylserine (PS) from phosphatidylcholine (PC) and L-serine was proposed.	Phosphatidylserines	70-88	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	10-22
33740632-5	2021	Using the HMSC-NH2-PLD, a high-efficient method for the conversion of phosphatidylserine (PS) from phosphatidylcholine (PC) and L-serine was proposed.	Phosphatidylserines	90-92	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	10-22
33740632-6	2021	The HMSC-NH2-PLD exhibited prominent enzymatic activity for PS synthesis, the maximal conversion of PS was 90.40% with a catalytic efficiency (CE) of 31.95 mumol / (g h under the optimal conditions.	Phosphatidylserines	60-62	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	4-16
34043641-8	2021	We found that cpnA- cells bound higher amounts of Annexin V, a PS binding protein, than parental cells and showed that unlabeled Annexin V reduced the increased cell adhesion property of cpnA- cells.	Phosphatidylserines	63-65	annexin A5	Homo sapiens	50-59
34043641-8	2021	We found that cpnA- cells bound higher amounts of Annexin V, a PS binding protein, than parental cells and showed that unlabeled Annexin V reduced the increased cell adhesion property of cpnA- cells.	Phosphatidylserines	63-65	annexin A5	Homo sapiens	129-138
33876786-0	2021	A comparative study of the effects of phosphatidylserine rich in DHA and EPA on Abeta-induced Alzheimer"s disease using cell models.	Phosphatidylserines	38-56	amyloid beta (A4) precursor protein	Mus musculus	80-85
34013588-0	2021	Microglial MERTK eliminates phosphatidylserine-displaying inhibitory post-synapses.	Phosphatidylserines	28-46	MER proto-oncogene tyrosine kinase	Mus musculus	11-16
34013588-3	2021	Here, we generated conditional knockout mice with neuronal-specific deletion of the flippase chaperone Cdc50a, to induce stable exposure of phosphatidylserine, a well-known "eat-me" signal for apoptotic cells, on the neuronal outer membrane.	Phosphatidylserines	140-158	transmembrane protein 30A	Mus musculus	103-109
34013588-4	2021	Surprisingly, acute Cdc50a deletion in mature neurons causes preferential phosphatidylserine exposure in neuronal somas and specific loss of inhibitory post-synapses without effects on other synapses, resulting in abnormal excitability and seizures.	Phosphatidylserines	74-92	transmembrane protein 30A	Mus musculus	20-26
34003451-7	2021	HSPA8 showed high selectivity for negatively charged phospholipids, such as phosphatidylserine and cardiolipin, and low affinity for phosphatidylcholine.	Phosphatidylserines	76-94	heat shock protein family A (Hsp70) member 8	Homo sapiens	0-5
34020328-2	2021	However, commonly used PtdSer binding molecules such as Annexin V cannot block PtdSer-mediated viral infection.	Phosphatidylserines	23-29	annexin A5	Homo sapiens	56-65
33909989-0	2021	Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine.	Phosphatidylserines	63-81	GABA type A receptor associated protein like 1	Homo sapiens	43-47
33909989-4	2021	Here, we discover that all ATG8s can also undergo alternative lipidation to phosphatidylserine (PS) during CASM, induced pharmacologically, by LC3-associated phagocytosis or influenza A virus infection, in mammalian cells.	Phosphatidylserines	76-94	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	143-146
33909989-4	2021	Here, we discover that all ATG8s can also undergo alternative lipidation to phosphatidylserine (PS) during CASM, induced pharmacologically, by LC3-associated phagocytosis or influenza A virus infection, in mammalian cells.	Phosphatidylserines	96-98	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	143-146
34025450-11	2021	Adrenaline-collagen synergism, expressed as PS exposure, was significantly reduced by cyclooxygenase inhibitor (acetylsalicic acid), GPIIb/IIIa receptor blocker (tirofiban), and P2Y12 receptor antagonist (PSB 0739).	Phosphatidylserines	44-46	integrin subunit alpha 2b	Homo sapiens	133-138
33565221-1	2021	ATP8A2 is a P4-ATPase that flips phosphatidylserine across membranes to generate and maintain transmembrane phospholipid asymmetry.	Phosphatidylserines	33-51	ATPase phospholipid transporting 8A2	Homo sapiens	0-6
33219895-8	2021	Furthermore, we detected elevated levels of IL-8, IL-6, and TNF-alpha in EH patients could activate platelets/ECs and induce elevated PS exposure on their membranes.	Phosphatidylserines	134-136	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
33219895-8	2021	Furthermore, we detected elevated levels of IL-8, IL-6, and TNF-alpha in EH patients could activate platelets/ECs and induce elevated PS exposure on their membranes.	Phosphatidylserines	134-136	interleukin 6	Homo sapiens	50-54
33219895-8	2021	Furthermore, we detected elevated levels of IL-8, IL-6, and TNF-alpha in EH patients could activate platelets/ECs and induce elevated PS exposure on their membranes.	Phosphatidylserines	134-136	tumor necrosis factor	Homo sapiens	60-69
33935042-0	2021	The Peroxisomal Localization of Hsd17b4 Is Regulated by Its Interaction with Phosphatidylserine.	Phosphatidylserines	77-95	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	32-39
33935042-8	2021	In addition, translocation of PS to the outer leaflet of the plasma membrane enriched Hsd17b4 in peroxisomes.	Phosphatidylserines	30-32	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	86-93
33861586-3	2021	Annexins A1 and A2 (ANXA1 and ANXA2, respectively) are structurally similar and bind to negatively charged phosphatidylserine (PS) to induce membrane cross-linking and to promote fusion, which are both essential processes that occur during membrane repair.	Phosphatidylserines	107-125	annexin A1	Homo sapiens	20-25
33861586-3	2021	Annexins A1 and A2 (ANXA1 and ANXA2, respectively) are structurally similar and bind to negatively charged phosphatidylserine (PS) to induce membrane cross-linking and to promote fusion, which are both essential processes that occur during membrane repair.	Phosphatidylserines	107-125	annexin A2	Homo sapiens	30-35
33861586-3	2021	Annexins A1 and A2 (ANXA1 and ANXA2, respectively) are structurally similar and bind to negatively charged phosphatidylserine (PS) to induce membrane cross-linking and to promote fusion, which are both essential processes that occur during membrane repair.	Phosphatidylserines	127-129	annexin A1	Homo sapiens	20-25
33861586-3	2021	Annexins A1 and A2 (ANXA1 and ANXA2, respectively) are structurally similar and bind to negatively charged phosphatidylserine (PS) to induce membrane cross-linking and to promote fusion, which are both essential processes that occur during membrane repair.	Phosphatidylserines	127-129	annexin A2	Homo sapiens	30-35
33995667-12	2021	Treatment with lactadherin, a PS-binding scavenging molecule, markedly reduced the adhesion of BCMPs and abolished their procoagulant activity, but this was not observed with tissue factor antibody treatment.	Phosphatidylserines	30-32	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	15-26
33995667-16	2021	Pretreatment with lactadherin increased uptake of both PS+ BCMPs and cancer cells by endothelial cells and limited the transendothelial migration of cancer cells.	Phosphatidylserines	55-58	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	18-29
33723887-6	2021	Pharmacological inhibition of either integrin alphaLbeta2 or FGF2 hampered cytokine induction in monocytic cultured cells elicited by PS-exposing Akata EVs, suggesting the involvement of these proteins in EV-mediated TAM induction in EBV lymphomas.	Phosphatidylserines	134-136	fibroblast growth factor 2	Homo sapiens	61-65
33604692-0	2021	Secretion of Recombinant Human Annexin V in Fusion with the Super Folder GFP for Labelling Phosphatidylserine-Exposing Membranes.	Phosphatidylserines	91-109	annexin A5	Homo sapiens	31-40
33742437-6	2021	Platelets accelerate the initiation and velocity of thrombin generation by phosphatidylserine exposure, granule content release and surface receptor interaction with coagulation proteins.	Phosphatidylserines	75-93	coagulation factor II, thrombin	Homo sapiens	52-60
33604931-4	2021	We show that the GRAM domain of GRAMD1b, a coincidence detector for anionic lipids, including phosphatidylserine (PS), and cholesterol, possesses distinct but synergistic sites for sensing accessible cholesterol and anionic lipids.	Phosphatidylserines	94-112	GRAM domain containing 1B	Homo sapiens	32-39
33604931-4	2021	We show that the GRAM domain of GRAMD1b, a coincidence detector for anionic lipids, including phosphatidylserine (PS), and cholesterol, possesses distinct but synergistic sites for sensing accessible cholesterol and anionic lipids.	Phosphatidylserines	114-116	GRAM domain containing 1B	Homo sapiens	32-39
33539790-4	2021	Recent experimental studies have shown that for TIM-dependent EBOV entry, a Mucin-Like Domain (MLD) with a length of at least 120 amino acids is required, possibly due to the increase of area of the PS-coated surface sampled.	Phosphatidylserines	199-201	hepatitis A virus cellular receptor 1	Homo sapiens	48-51
33539790-4	2021	Recent experimental studies have shown that for TIM-dependent EBOV entry, a Mucin-Like Domain (MLD) with a length of at least 120 amino acids is required, possibly due to the increase of area of the PS-coated surface sampled.	Phosphatidylserines	199-201	LOC100508689	Homo sapiens	76-81
33333179-8	2021	We demonstrate that in Atg2 mutants (Atg2-), phosphatidylinositol (PI), negatively charged phosphatidylserine (PS), and phosphatidic acid (PA) with longer fatty acyl chains accumulate on stalled, negatively charged phagophores.	Phosphatidylserines	91-109	Autophagy-related 2	Drosophila melanogaster	23-27
33333179-9	2021	Tandem mass spectrometry analysis of lipid species composing the lipid classes reveal the enrichment of unsaturated PE and phosphatidylcholine (PC) in controls versus PI, PS and PA species in Atg2-.	Phosphatidylserines	171-173	Autophagy-related 2	Drosophila melanogaster	192-196
33431739-7	2021	Phosphatidylserine (PS) exposure was detected by Annexin-V-FITC, intracellular calcium by Fluo4/AM, cellular volume from forward scatter (FSC), and oxidative stress by 2",7"-dichlorodihydrofluorescein diacetate (H2DCFDA).	Phosphatidylserines	0-18	annexin A5	Homo sapiens	49-58
33431739-7	2021	Phosphatidylserine (PS) exposure was detected by Annexin-V-FITC, intracellular calcium by Fluo4/AM, cellular volume from forward scatter (FSC), and oxidative stress by 2",7"-dichlorodihydrofluorescein diacetate (H2DCFDA).	Phosphatidylserines	20-22	annexin A5	Homo sapiens	49-58
32997199-4	2021	Here, we show that the membrane binding and curvature-inducing ENTH domain of epsin1 is regulated by phosphatidylserine (PS).	Phosphatidylserines	101-119	clathrin interactor 1	Homo sapiens	63-67
32997199-4	2021	Here, we show that the membrane binding and curvature-inducing ENTH domain of epsin1 is regulated by phosphatidylserine (PS).	Phosphatidylserines	101-119	epsin 1	Homo sapiens	78-84
32997199-4	2021	Here, we show that the membrane binding and curvature-inducing ENTH domain of epsin1 is regulated by phosphatidylserine (PS).	Phosphatidylserines	121-123	clathrin interactor 1	Homo sapiens	63-67
32997199-4	2021	Here, we show that the membrane binding and curvature-inducing ENTH domain of epsin1 is regulated by phosphatidylserine (PS).	Phosphatidylserines	121-123	epsin 1	Homo sapiens	78-84
32997199-5	2021	ENTH binds to membranes in a PI(4,5)P2-dependent manner but only induces curvature in the presence of PS.	Phosphatidylserines	102-104	clathrin interactor 1	Homo sapiens	0-4
32997199-6	2021	On PS-containing membranes, the ENTH domain forms rigid homo-oligomers and assembles into clusters.	Phosphatidylserines	3-5	clathrin interactor 1	Homo sapiens	32-36
33479740-0	2021	Phosphatidylserine and Phosphatidylethanolamine Regulate the Structure and Function of FVIIaand Its Interaction with Soluble Tissue Factor.	Phosphatidylserines	0-18	coagulation factor III, tissue factor	Homo sapiens	125-138
33479740-3	2021	FIXa and FXa are regulated by binding to phosphatidylserine (PS)-containing membranes via their gamma-carboxy-glutamic acid (Gla) and epidermal growth-factor (EGF) domains.	Phosphatidylserines	41-59	coagulation factor X	Homo sapiens	9-12
33479740-3	2021	FIXa and FXa are regulated by binding to phosphatidylserine (PS)-containing membranes via their gamma-carboxy-glutamic acid (Gla) and epidermal growth-factor (EGF) domains.	Phosphatidylserines	41-59	epidermal growth factor	Homo sapiens	134-157
33479740-3	2021	FIXa and FXa are regulated by binding to phosphatidylserine (PS)-containing membranes via their gamma-carboxy-glutamic acid (Gla) and epidermal growth-factor (EGF) domains.	Phosphatidylserines	41-59	epidermal growth factor	Homo sapiens	159-162
33479740-3	2021	FIXa and FXa are regulated by binding to phosphatidylserine (PS)-containing membranes via their gamma-carboxy-glutamic acid (Gla) and epidermal growth-factor (EGF) domains.	Phosphatidylserines	61-63	coagulation factor X	Homo sapiens	9-12
33479740-3	2021	FIXa and FXa are regulated by binding to phosphatidylserine (PS)-containing membranes via their gamma-carboxy-glutamic acid (Gla) and epidermal growth-factor (EGF) domains.	Phosphatidylserines	61-63	epidermal growth factor	Homo sapiens	134-157
33479740-3	2021	FIXa and FXa are regulated by binding to phosphatidylserine (PS)-containing membranes via their gamma-carboxy-glutamic acid (Gla) and epidermal growth-factor (EGF) domains.	Phosphatidylserines	61-63	epidermal growth factor	Homo sapiens	159-162
33538595-0	2021	Membrane Remodeling and Stimulation of Aggregation Following alpha-Synuclein Adsorption to Phosphotidylserine Vesicles.	Phosphatidylserines	91-109	synuclein alpha	Homo sapiens	61-76
33571185-8	2021	Inhibiting the release of Ca2+ from the ER, either pharmacologically or genetically, specifically impairs PS exposure on necrotic but not apoptotic cells.	Phosphatidylserines	106-108	epiregulin	Homo sapiens	40-42
33571185-9	2021	On the contrary, inhibiting the reuptake of cytoplasmic Ca2+ into the ER induces ectopic necrosis and PS exposure.	Phosphatidylserines	102-104	epiregulin	Homo sapiens	70-72
33571185-11	2021	Furthermore, unlike in mutants of DEG/ENaC channels, in dominant mutants of deg-3 and trp-4, which encode Ca2+ channels, PS exposure on necrotic neurons does not rely on the ER Ca2+ pool.	Phosphatidylserines	121-123	ANK_REP_REGION domain-containing protein	Caenorhabditis elegans	86-91
33571185-14	2021	Moreover, we found that ANOH-1, the worm homolog of mammalian phospholipid scramblase TMEM16F, is necessary for efficient PS exposure in thapsgargin-treated worms and trp-4 mutants, like in mec-4 mutants.	Phosphatidylserines	122-124	anoctamin 6	Homo sapiens	86-93
33571185-14	2021	Moreover, we found that ANOH-1, the worm homolog of mammalian phospholipid scramblase TMEM16F, is necessary for efficient PS exposure in thapsgargin-treated worms and trp-4 mutants, like in mec-4 mutants.	Phosphatidylserines	122-124	Degenerin mec-4	Caenorhabditis elegans	190-195
33526670-4	2021	MD simulations show that these equally charged KRAS mutant anchors exhibit distinct interactions and packing patterns with different phosphatidylserine (PtdSer) species, indicating that prenylated PBD-bilayer interactions extend beyond electrostatics.	Phosphatidylserines	133-151	KRAS proto-oncogene, GTPase	Homo sapiens	47-51
33526670-4	2021	MD simulations show that these equally charged KRAS mutant anchors exhibit distinct interactions and packing patterns with different phosphatidylserine (PtdSer) species, indicating that prenylated PBD-bilayer interactions extend beyond electrostatics.	Phosphatidylserines	153-159	KRAS proto-oncogene, GTPase	Homo sapiens	47-51
32853880-2	2021	Phosphatidylserine (PtdSer) is localized at the inner leaflet of plasma membranes as a result of the action of flippases (ATP11A and 11C).	Phosphatidylserines	0-18	ATPase phospholipid transporting 11A	Homo sapiens	122-128
32853880-2	2021	Phosphatidylserine (PtdSer) is localized at the inner leaflet of plasma membranes as a result of the action of flippases (ATP11A and 11C).	Phosphatidylserines	20-26	ATPase phospholipid transporting 11A	Homo sapiens	122-128
33538769-10	2021	The lgals3-/- photoreceptor outer segments display normal diurnal PS exposure at distal tips.	Phosphatidylserines	66-68	lectin, galactose binding, soluble 3	Mus musculus	4-10
33515436-8	2021	IFNalpha or IFNbeta treatment efficiently upregulated Casp11 and Gsdmd, phosphatidylserine exposure, and TF activity of macrophages.	Phosphatidylserines	72-90	interferon alpha	Mus musculus	0-8
33515436-8	2021	IFNalpha or IFNbeta treatment efficiently upregulated Casp11 and Gsdmd, phosphatidylserine exposure, and TF activity of macrophages.	Phosphatidylserines	72-90	interferon alpha	Mus musculus	12-19
33440601-9	2021	AnxA1 peptidomimetic treatment also increased the concentration of phosphatidylserines and oxidized phosphocholines, which are lipid biomarkers related to the inflammatory resolution pathway.	Phosphatidylserines	67-86	annexin A1	Mus musculus	0-5
33413430-10	2021	First, recognition of phosphatidylserine molecules on Apo-J cells by THP-1 macrophages downregulates TNF-alpha production.	Phosphatidylserines	22-40	GLI family zinc finger 2	Homo sapiens	69-74
33413430-10	2021	First, recognition of phosphatidylserine molecules on Apo-J cells by THP-1 macrophages downregulates TNF-alpha production.	Phosphatidylserines	22-40	tumor necrosis factor	Homo sapiens	101-110
33419210-3	2021	We observed that both PKCzeta and PKCiota interact with phosphatidic acid and phosphatidylserine.	Phosphatidylserines	78-96	protein kinase C zeta	Homo sapiens	22-29
33205488-3	2021	In mammalian cells, two distinct enzymes phosphatidylserine synthases-1 (PSS1) and -2 (PSS2) in the mitochondria-associated membrane (MAM) in the ER perform de novo synthesis of PS.	Phosphatidylserines	73-75	phosphatidylserine synthase 2	Homo sapiens	87-91
33205488-3	2021	In mammalian cells, two distinct enzymes phosphatidylserine synthases-1 (PSS1) and -2 (PSS2) in the mitochondria-associated membrane (MAM) in the ER perform de novo synthesis of PS.	Phosphatidylserines	73-75	sarcoglycan gamma	Homo sapiens	134-137
33683697-2	2021	In the presence of Ca2+ ions, annexin V has a strong binding affinity for phosphatidylserine, a membrane phospholipid that during apoptosis is translocated from the inner side of the cell membrane to its outer side.	Phosphatidylserines	74-92	annexin A5	Homo sapiens	30-39
32961573-8	2021	RESULTS:  By 6 minutes, PS+ platelets were distributed throughout the platelet deposits and became highly spatially sorted by 15 minutes when thrombin and fibrin were blocked with Phe-Pro-Arg-chloromethylketone (PPACK).	Phosphatidylserines	24-27	coagulation factor II, thrombin	Homo sapiens	142-150
33115868-0	2020	Phosphotidylethanolamine and phosphatidylserine synergize to enhance GAS6/AXL-mediated virus infection and efferocytosis.	Phosphatidylserines	29-47	growth arrest specific 6	Equus caballus	69-73
33115868-0	2020	Phosphotidylethanolamine and phosphatidylserine synergize to enhance GAS6/AXL-mediated virus infection and efferocytosis.	Phosphatidylserines	29-47	AXL receptor tyrosine kinase	Equus caballus	74-77
33115868-4	2020	The presence of PE on the same surface as PS dramatically enhances recognition of PS by PS-binding proteins such as GAS6, PROS, and TIM1.	Phosphatidylserines	42-44	growth arrest specific 6	Equus caballus	116-120
33115868-4	2020	The presence of PE on the same surface as PS dramatically enhances recognition of PS by PS-binding proteins such as GAS6, PROS, and TIM1.	Phosphatidylserines	82-84	growth arrest specific 6	Equus caballus	116-120
33115868-4	2020	The presence of PE on the same surface as PS dramatically enhances recognition of PS by PS-binding proteins such as GAS6, PROS, and TIM1.	Phosphatidylserines	82-84	growth arrest specific 6	Equus caballus	116-120
33115868-5	2020	Liposomes containing both PE and PS bound to GAS6 and were engulfed by AXL-expressing cells much more efficiently than those containing PS alone.	Phosphatidylserines	33-35	growth arrest specific 6	Equus caballus	45-49
33115868-5	2020	Liposomes containing both PE and PS bound to GAS6 and were engulfed by AXL-expressing cells much more efficiently than those containing PS alone.	Phosphatidylserines	33-35	AXL receptor tyrosine kinase	Equus caballus	71-74
33115868-6	2020	Further, infection of AXL-expressing cells by infectious Zika virus or Ebola, Chikungunya or eastern equine encephalitis pseudoviruses was inhibited with greater efficiency by the liposomes containing both PS and PE compared to a mixture of liposomes separately composed of PS and PE.	Phosphatidylserines	206-208	AXL receptor tyrosine kinase	Homo sapiens	22-25
33115868-6	2020	Further, infection of AXL-expressing cells by infectious Zika virus or Ebola, Chikungunya or eastern equine encephalitis pseudoviruses was inhibited with greater efficiency by the liposomes containing both PS and PE compared to a mixture of liposomes separately composed of PS and PE.	Phosphatidylserines	274-276	AXL receptor tyrosine kinase	Homo sapiens	22-25
33518513-6	2021	We observed that partial Lpcat3 deficiency (approximately 75% reduction) in macrophages alters the PUFA composition of all phospholipid (PL) subclasses, including phosphatidylinositols and phosphatidylserines.	Phosphatidylserines	189-208	lysophosphatidylcholine acyltransferase 3	Mus musculus	25-31
33277360-3	2021	The Slp-4 C2A domain binds with low nanomolar apparent affinity to PIP2 in lipid vesicles that also contain background anionic lipids such as phosphatidylserine (PS), but much weaker when either the background anionic lipids or PIP2 are removed.	Phosphatidylserines	142-160	synaptotagmin-like 4	Mus musculus	4-9
33277360-3	2021	The Slp-4 C2A domain binds with low nanomolar apparent affinity to PIP2 in lipid vesicles that also contain background anionic lipids such as phosphatidylserine (PS), but much weaker when either the background anionic lipids or PIP2 are removed.	Phosphatidylserines	162-164	synaptotagmin-like 4	Mus musculus	4-9
33304145-9	2020	Phosphatidylserine (PS) exposure was detected by Annexin-V-FITC, cytosolic calcium with Fluo4/AM, and reactive oxygen species with H2DCFDA.	Phosphatidylserines	0-18	annexin A5	Homo sapiens	49-58
33304145-9	2020	Phosphatidylserine (PS) exposure was detected by Annexin-V-FITC, cytosolic calcium with Fluo4/AM, and reactive oxygen species with H2DCFDA.	Phosphatidylserines	20-22	annexin A5	Homo sapiens	49-58
33169982-3	2020	Inspired by the "eat me" signal, phosphatidylserine (PS), mediated phagocytic clearance of apoptotic bodies, in this study, the matrix metalloproteinase 2 (MMP2)-sensitive PS-modified nanoparticles were developed.	Phosphatidylserines	53-55	matrix metallopeptidase 2	Mus musculus	128-154
33169982-3	2020	Inspired by the "eat me" signal, phosphatidylserine (PS), mediated phagocytic clearance of apoptotic bodies, in this study, the matrix metalloproteinase 2 (MMP2)-sensitive PS-modified nanoparticles were developed.	Phosphatidylserines	53-55	matrix metallopeptidase 2	Mus musculus	156-160
33169982-4	2020	In the design, the PS is externalized to the nanoparticles" surface only when the nanoparticles reach the MMP2-overexpressing tumor site, allowing for the TAM-specific phagocytosis.	Phosphatidylserines	19-21	matrix metallopeptidase 2	Mus musculus	106-110
33208899-11	2020	Findings are therefore consistent with the presence of PIEZO1 in sickle cells, able to mediate Ca2+ entry but that PKC was also involved in both Ca2+ entry and PS exposure.	Phosphatidylserines	160-162	proline rich transmembrane protein 2	Homo sapiens	115-118
33141558-4	2020	We find that NPC2 binds fluorescence- and spin-labeled analogues of phosphatidylcholine (PC), phosphatidylserine, phosphatidylinositol (PI), and sphingomyelin.	Phosphatidylserines	94-112	sterol transporter	Saccharomyces cerevisiae S288C	13-17
32706246-2	2020	As a model of molsidomine mitotoxicity, the reaction of cytochrome c with phosphatidylserine (PS)- and cardiolipin (CL)-containing liposomes was investigated in oxidative/nitrosative conditions imposed by SIN-1 decomposition, which renders peroxynitrite (ONOO-) as a main reactive product.	Phosphatidylserines	74-92	cytochrome c, somatic	Homo sapiens	56-68
32706246-2	2020	As a model of molsidomine mitotoxicity, the reaction of cytochrome c with phosphatidylserine (PS)- and cardiolipin (CL)-containing liposomes was investigated in oxidative/nitrosative conditions imposed by SIN-1 decomposition, which renders peroxynitrite (ONOO-) as a main reactive product.	Phosphatidylserines	94-96	cytochrome c, somatic	Homo sapiens	56-68
32706246-7	2020	PS- and CL-containing liposomes challenged by SIN-1 were analyzed by Fourier Transform Infrared spectroscopy that revealed oxidation, trans-isomerization, and nitration.	Phosphatidylserines	0-2	MAPK associated protein 1	Homo sapiens	46-51
33928230-6	2020	Results: IBI104 blocks phosphatidylserine interaction with TIM-3 but does not interfere with the interaction of TIM-3 with galectin-9 in ELISA assays.	Phosphatidylserines	23-41	hepatitis A virus cellular receptor 2	Mus musculus	59-64
32424239-8	2020	Mechanistically, MG53 translocated to the injury site on RPT cells and bound to phosphatidylserine to protect RPT cells from iopromide-induced injury.	Phosphatidylserines	80-98	tripartite motif containing 72	Homo sapiens	17-21
32817253-4	2020	Loss of ALA3 function resulted in loss of polar localization of apical PS and significantly decreased PS distribution, suggesting that ALA3 is a key regulator for establishing and maintaining the polar localization of apical PS in pollen tubes.	Phosphatidylserines	71-73	aminophospholipid ATPase 3	Arabidopsis thaliana	8-12
32817253-4	2020	Loss of ALA3 function resulted in loss of polar localization of apical PS and significantly decreased PS distribution, suggesting that ALA3 is a key regulator for establishing and maintaining the polar localization of apical PS in pollen tubes.	Phosphatidylserines	71-73	aminophospholipid ATPase 3	Arabidopsis thaliana	135-139
32997992-1	2020	ATP11C, a plasma membrane phospholipid flippase, maintains the asymmetric distribution of phosphatidylserine accumulated in the inner leaflet.	Phosphatidylserines	90-108	ATPase phospholipid transporting 11C	Homo sapiens	0-6
32709749-5	2020	Instead, we found that TA and EGCG mainly acted as fluorescence quenchers that rapidly suppress the fluorophores conjugated to annexin V, a phosphatidylserine-binding probe commonly used to report on TMEM16 CaPLSase activity.	Phosphatidylserines	140-158	annexin A5	Homo sapiens	127-136
32825419-4	2020	To elucidate this relationship, we determined the effect of phosphatidylserine (PS)-binding on the secondary structure and chaperone functions of HspA1A.	Phosphatidylserines	60-78	heat shock protein family A (Hsp70) member 1A	Homo sapiens	146-152
32825419-4	2020	To elucidate this relationship, we determined the effect of phosphatidylserine (PS)-binding on the secondary structure and chaperone functions of HspA1A.	Phosphatidylserines	80-82	heat shock protein family A (Hsp70) member 1A	Homo sapiens	146-152
32825419-7	2020	In contrast, PS-binding showed subtle but consistent increases in HspA1A"s refolding activities.	Phosphatidylserines	13-15	heat shock protein family A (Hsp70) member 1A	Homo sapiens	66-72
32824918-8	2020	Considering that insulin granules are enriched in phosphatidylserine (PS), the property of lipid vesicles containing negatively charged lipids was also evaluated.	Phosphatidylserines	50-68	insulin	Homo sapiens	17-24
32824918-8	2020	Considering that insulin granules are enriched in phosphatidylserine (PS), the property of lipid vesicles containing negatively charged lipids was also evaluated.	Phosphatidylserines	70-72	insulin	Homo sapiens	17-24
32776042-10	2020	Furthermore, flow cytometry using Annexin V-FITC/propidium iodide (PI) double staining determines the quantitative discrimination of early apoptosis by the externalization of phosphatidylserine.	Phosphatidylserines	175-193	annexin A5	Homo sapiens	34-43
32452062-0	2020	A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding.	Phosphatidylserines	72-90	adhesion G protein-coupled receptor G1	Homo sapiens	22-27
32452062-5	2020	Phosphatidylserine (PS) on presynaptic elements binds GPR56 in a domain-specific manner, and microglia-specific deletion of Gpr56 leads to increased synapses as a result of reduced microglial engulfment of PS+ presynaptic inputs.	Phosphatidylserines	0-18	adhesion G protein-coupled receptor G1	Homo sapiens	54-59
32452062-5	2020	Phosphatidylserine (PS) on presynaptic elements binds GPR56 in a domain-specific manner, and microglia-specific deletion of Gpr56 leads to increased synapses as a result of reduced microglial engulfment of PS+ presynaptic inputs.	Phosphatidylserines	20-22	adhesion G protein-coupled receptor G1	Homo sapiens	54-59
32657463-5	2020	In hippocampal neuron and microglia co-cultures, synapse elimination can be partially prevented by blocking accessibility of exposed PS using Annexin V or through microglial loss of TREM2.	Phosphatidylserines	133-135	annexin A5	Mus musculus	142-151
32657463-7	2020	Mice deficient in C1q, which fail to properly refine retinogeniculate connections, have elevated presynaptic PS exposure and reduced PS engulfment by microglia.	Phosphatidylserines	109-111	complement component 1, q subcomponent, alpha polypeptide	Mus musculus	18-21
32879883-6	2020	This inhibitory effect of VEGF was not influenced by masking of phosphatidylserine (PS) on the surface of apoptotic cells and was partially mediated by the PI3K-Akt signaling pathway.	Phosphatidylserines	64-82	vascular endothelial growth factor A	Homo sapiens	26-30
32879883-6	2020	This inhibitory effect of VEGF was not influenced by masking of phosphatidylserine (PS) on the surface of apoptotic cells and was partially mediated by the PI3K-Akt signaling pathway.	Phosphatidylserines	84-86	vascular endothelial growth factor A	Homo sapiens	26-30
32473247-3	2020	Therefore, we aimed to prepare metformin containing phosphatidylserine nanoliposomes formulation (MET-PSL) and to evaluate its effect on rats subjected to AD.	Phosphatidylserines	52-70	MET proto-oncogene, receptor tyrosine kinase	Rattus norvegicus	98-101
32851152-4	2020	Lipid-protein interactions with phosphatidylserine and phosphatidylethanolamine lipids, in particular, stabilize the residues 374 to 390 of NTS1 into forming a helix.	Phosphatidylserines	32-50	neurotensin	Homo sapiens	140-144
32806720-5	2020	Annexin V staining revealed that phosphatidylserine (PtdSer), which is known as an "eat-me" signal that triggers the internalization of apoptotic cells by macrophages, is exposed on the surface of secreted melanosome clusters.	Phosphatidylserines	33-51	annexin A5	Homo sapiens	0-9
32806720-5	2020	Annexin V staining revealed that phosphatidylserine (PtdSer), which is known as an "eat-me" signal that triggers the internalization of apoptotic cells by macrophages, is exposed on the surface of secreted melanosome clusters.	Phosphatidylserines	53-59	annexin A5	Homo sapiens	0-9
32628014-10	2020	Kinetic Method experiments and theory show that the gas-phase acidities of these phospholipids are high but less extreme than their GB values, with phosphatidylserine and phosphatidylglycerol being the most acidic.	Phosphatidylserines	148-166	gastrin	Homo sapiens	52-55
32690708-4	2020	We identified the gene encoding PTDSS1, an enzyme that synthesizes phosphatidylserine (PS), a phospholipid constituent of the inner layer of the plasma membrane (PM).	Phosphatidylserines	67-85	ptdss1	None	32-38
32690708-4	2020	We identified the gene encoding PTDSS1, an enzyme that synthesizes phosphatidylserine (PS), a phospholipid constituent of the inner layer of the plasma membrane (PM).	Phosphatidylserines	87-89	ptdss1	None	32-38
32690708-5	2020	In PTDSS1-deficient cells where PS is low, LDL cholesterol leaves lysosomes but fails to reach the ER, instead accumulating in the PM.	Phosphatidylserines	32-34	ptdss1	None	3-9
32724374-8	2020	Furthermore, it was revealed that AGXT2L1 may regulate phosphatidylinositol and phosphatidylserine metabolism in cancerous tissues, and that decreased AGXT2L1 expression could induce autophagy in CRC cells.	Phosphatidylserines	80-98	ethanolamine-phosphate phospho-lyase	Homo sapiens	34-41
31802427-7	2020	A PS-targeting VTA was created by conjugation of annexin V with human thrombin and administered intravenously 3 weeks post-GKS or sham.	Phosphatidylserines	2-4	annexin A5	Homo sapiens	49-58
31802427-7	2020	A PS-targeting VTA was created by conjugation of annexin V with human thrombin and administered intravenously 3 weeks post-GKS or sham.	Phosphatidylserines	2-4	coagulation factor II, thrombin	Homo sapiens	70-78
32632018-5	2020	Interestingly, adiponectin selectively bound several anionic phospholipids and sphingolipids, including phosphatidylserine, ceramide-1-phosphate, glucosylceramide, and sulfatide, via the C1q domain in an oligomerization-dependent fashion.	Phosphatidylserines	104-122	adiponectin, C1Q and collagen domain containing	Homo sapiens	15-26
32603422-9	2020	These results demonstrate that GPVI supports aggregation and PS exposure under flow on collagen and noncollagen surfaces, but not adhesion.	Phosphatidylserines	61-63	glycoprotein VI platelet	Homo sapiens	31-35
32674302-4	2020	Lactadherin is a generic and validated EV marker, which enables an effective labelling of phosphatidylserine (PS) exposing EVs.	Phosphatidylserines	90-108	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	0-11
32674302-4	2020	Lactadherin is a generic and validated EV marker, which enables an effective labelling of phosphatidylserine (PS) exposing EVs.	Phosphatidylserines	110-112	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	0-11
32664537-3	2020	We analyzed the neuroprotective effects of soybean-derived phosphatidylserine (Bean-PS) on cognitive function, changes in the central cholinergic systems, and neural activity in TMT-induced memory deficits in a rat model.	Phosphatidylserines	59-77	brain expressed, associated with NEDD4, 1	Rattus norvegicus	79-83
32733436-4	2020	Phosphatidylserine can be reversibly exposed to viable cells as a result of a calcium-activated phospholipid scramblase named TMEM16F.	Phosphatidylserines	0-18	anoctamin 6	Rattus norvegicus	126-133
32733436-11	2020	Our data indicate that reducing neuronal phosphatidylserine-exposure via deficiency of TMEM16F blocks phagocytosis of neurons and rescues stressed-but-still-viable neurons in the penumbra, which may contribute to reducing infarct volume and improving functional recovering.	Phosphatidylserines	41-59	anoctamin 6	Rattus norvegicus	87-94
32640697-2	2020	The PS-binding protein Tim-4 secures apoptotic cells to phagocytes to facilitate the engulfment of apoptotic cells.	Phosphatidylserines	4-6	T cell immunoglobulin and mucin domain containing 4	Homo sapiens	23-28
32222693-5	2020	We report that TMEM16F inhibitors tannic acid (TA) and epigallocatechin-3-gallate (EGCG) inhibit LPA-induced PS exposure and calcium uptake at low micromolar concentrations; fluoxetine, an antidepressant and a known activator of TMEM16F, enhances these processes.	Phosphatidylserines	109-111	anoctamin 6	Homo sapiens	15-22
32202953-9	2020	We observed that anticardiolipin from periodontitis subjects competes for annexin V on an artificial phosphatidylserine monolayer, replicating a key activity of autoantibodies found in patients with antiphospholipid syndrome.	Phosphatidylserines	101-119	annexin A5	Homo sapiens	74-83
32526790-11	2020	Thrombin generation was faster with small, but accelerated by PS exposure and epinephrine-coactivated large platelets.	Phosphatidylserines	62-64	coagulation factor II, thrombin	Homo sapiens	0-8
32413406-6	2020	We find that phosphatidylserine and ergosterol are essential for Lyp1 function, and the transport activity displays a sigmoidal relationship with the concentration of these lipids.	Phosphatidylserines	13-31	lysine permease	Saccharomyces cerevisiae S288C	65-69
32327560-1	2020	Osh6 and Osh7 are lipid transfer proteins (LTPs) that move phosphatidylserine (PS) from the endoplasmic reticulum (ER) to the plasma membrane (PM).	Phosphatidylserines	59-77	oxysterol-binding protein OSH6	Saccharomyces cerevisiae S288C	0-4
32327560-1	2020	Osh6 and Osh7 are lipid transfer proteins (LTPs) that move phosphatidylserine (PS) from the endoplasmic reticulum (ER) to the plasma membrane (PM).	Phosphatidylserines	59-77	oxysterol-binding protein related protein OSH7	Saccharomyces cerevisiae S288C	9-13
32327560-1	2020	Osh6 and Osh7 are lipid transfer proteins (LTPs) that move phosphatidylserine (PS) from the endoplasmic reticulum (ER) to the plasma membrane (PM).	Phosphatidylserines	79-81	oxysterol-binding protein OSH6	Saccharomyces cerevisiae S288C	0-4
32327560-1	2020	Osh6 and Osh7 are lipid transfer proteins (LTPs) that move phosphatidylserine (PS) from the endoplasmic reticulum (ER) to the plasma membrane (PM).	Phosphatidylserines	79-81	oxysterol-binding protein related protein OSH7	Saccharomyces cerevisiae S288C	9-13
32327560-6	2020	Mutations in the Ist2 tail phenocopy osh6Delta osh7Delta deletion: they decrease cellular PS levels, and block PS transport to the PM.	Phosphatidylserines	90-92	Ist2p	Saccharomyces cerevisiae S288C	17-21
32344036-5	2020	ATP11A, ATP11B, and ATP11C belong to class VI of the P4 flippase family (vertebrates) and are responsible for the movement of phosphatidylserine (PS) from the outer leaflet to the inner leaflet of the PM.	Phosphatidylserines	126-144	ATPase phospholipid transporting 11A	Danio rerio	0-6
32344036-5	2020	ATP11A, ATP11B, and ATP11C belong to class VI of the P4 flippase family (vertebrates) and are responsible for the movement of phosphatidylserine (PS) from the outer leaflet to the inner leaflet of the PM.	Phosphatidylserines	126-144	ATPase phospholipid transporting 11B	Danio rerio	8-14
32344036-5	2020	ATP11A, ATP11B, and ATP11C belong to class VI of the P4 flippase family (vertebrates) and are responsible for the movement of phosphatidylserine (PS) from the outer leaflet to the inner leaflet of the PM.	Phosphatidylserines	126-144	ATPase phospholipid transporting 11C	Danio rerio	20-26
32344036-5	2020	ATP11A, ATP11B, and ATP11C belong to class VI of the P4 flippase family (vertebrates) and are responsible for the movement of phosphatidylserine (PS) from the outer leaflet to the inner leaflet of the PM.	Phosphatidylserines	146-148	ATPase phospholipid transporting 11A	Danio rerio	0-6
32344036-5	2020	ATP11A, ATP11B, and ATP11C belong to class VI of the P4 flippase family (vertebrates) and are responsible for the movement of phosphatidylserine (PS) from the outer leaflet to the inner leaflet of the PM.	Phosphatidylserines	146-148	ATPase phospholipid transporting 11B	Danio rerio	8-14
32344036-5	2020	ATP11A, ATP11B, and ATP11C belong to class VI of the P4 flippase family (vertebrates) and are responsible for the movement of phosphatidylserine (PS) from the outer leaflet to the inner leaflet of the PM.	Phosphatidylserines	146-148	ATPase phospholipid transporting 11C	Danio rerio	20-26
32044399-10	2020	Finally, doxycycline induced the externalization phosphatidylserine - a well-known hallmark of apoptosis, confirmed by results of annexin V test.	Phosphatidylserines	49-67	annexin A5	Homo sapiens	130-139
32494719-4	2020	Here, we report that TMEM16F, a Ca2+-activated phospholipid scramblase (CaPLSase), plays an essential role in placental trophoblast fusion by translocating PS to cell surface independent of apoptosis.	Phosphatidylserines	156-158	anoctamin 6	Mus musculus	21-28
32478066-2	2020	The ability of EVs to support thrombin generation has been linked to their exposure of phosphatidylserine, an anionic phospholipid that is normally restricted to the inner leaflet of the plasma membrane but exposed on the outer leaflet during EV biogenesis.	Phosphatidylserines	87-105	coagulation factor II, thrombin	Homo sapiens	30-38
31915963-0	2020	Phosphatidylserine modulates response to oxidative stress through hormesis and increases lifespan via DAF-16 in Caenorhabditis elegans.	Phosphatidylserines	0-18	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	102-108
32064755-8	2020	The 4 most common pathological and pharmacological lipid markers were phosphatidylserine (PS), suggesting that timosaponin BII had protective effects on model cells related to the reduction oxidative stress and macrophage inflammation.	Phosphatidylserines	70-88	calcium voltage-gated channel subunit alpha1 E	Rattus norvegicus	123-126
32064755-8	2020	The 4 most common pathological and pharmacological lipid markers were phosphatidylserine (PS), suggesting that timosaponin BII had protective effects on model cells related to the reduction oxidative stress and macrophage inflammation.	Phosphatidylserines	90-92	calcium voltage-gated channel subunit alpha1 E	Rattus norvegicus	123-126
31612502-4	2020	This Nav 1.5-dependent Vm depolarization increases Rac1 colocalization with phosphatidylserine, to which it is anchored at the leading edge of migrating cells, promoting Rac1 activation.	Phosphatidylserines	76-94	sodium voltage-gated channel alpha subunit 5	Homo sapiens	5-12
31612502-4	2020	This Nav 1.5-dependent Vm depolarization increases Rac1 colocalization with phosphatidylserine, to which it is anchored at the leading edge of migrating cells, promoting Rac1 activation.	Phosphatidylserines	76-94	Rac family small GTPase 1	Homo sapiens	51-55
31612502-4	2020	This Nav 1.5-dependent Vm depolarization increases Rac1 colocalization with phosphatidylserine, to which it is anchored at the leading edge of migrating cells, promoting Rac1 activation.	Phosphatidylserines	76-94	Rac family small GTPase 1	Homo sapiens	170-174
30389273-7	2020	Rhodioloside administration showed atheroprotective effects on the apoE-/- mice with regulating the levels of 1 phosphatidylcholine, 2 phosphatidylserines, 5 alkyldiacylglycerols and 3 alkenyldiacylglycerols back to normal.	Phosphatidylserines	135-154	apolipoprotein E	Mus musculus	67-71
32056847-4	2020	Using a biocontained recombinant vesicular stomatitis virus pseudotype platform, we provide first evidence for a role of the cellular phosphatidylserine (PS) receptors of the T-cell immunoglobulin and mucin (TIM) protein family in HTNV and ANDV infection.	Phosphatidylserines	134-152	hepatitis A virus cellular receptor 1	Homo sapiens	175-206
32056847-4	2020	Using a biocontained recombinant vesicular stomatitis virus pseudotype platform, we provide first evidence for a role of the cellular phosphatidylserine (PS) receptors of the T-cell immunoglobulin and mucin (TIM) protein family in HTNV and ANDV infection.	Phosphatidylserines	134-152	hepatitis A virus cellular receptor 1	Homo sapiens	208-211
32056847-4	2020	Using a biocontained recombinant vesicular stomatitis virus pseudotype platform, we provide first evidence for a role of the cellular phosphatidylserine (PS) receptors of the T-cell immunoglobulin and mucin (TIM) protein family in HTNV and ANDV infection.	Phosphatidylserines	154-156	hepatitis A virus cellular receptor 1	Homo sapiens	175-206
32056847-4	2020	Using a biocontained recombinant vesicular stomatitis virus pseudotype platform, we provide first evidence for a role of the cellular phosphatidylserine (PS) receptors of the T-cell immunoglobulin and mucin (TIM) protein family in HTNV and ANDV infection.	Phosphatidylserines	154-156	hepatitis A virus cellular receptor 1	Homo sapiens	208-211
32075747-6	2020	In full-length Syt1, both Pb2+-complexed C2 domains associate with phosphatidylserine-containing membranes.	Phosphatidylserines	67-85	synaptotagmin 1	Homo sapiens	15-19
32265698-3	2020	Gal-1 is reported to inhibit neutrophil recruitment and induce surface exposure of phosphatidylserine (PS), an "eat me" signal on the surface of neutrophils, yet its role in resolution remains to be fully elucidated.	Phosphatidylserines	83-101	lectin, galactose binding, soluble 1	Mus musculus	0-5
32265698-3	2020	Gal-1 is reported to inhibit neutrophil recruitment and induce surface exposure of phosphatidylserine (PS), an "eat me" signal on the surface of neutrophils, yet its role in resolution remains to be fully elucidated.	Phosphatidylserines	103-105	lectin, galactose binding, soluble 1	Mus musculus	0-5
32041906-2	2020	Phosphoinositide gradients play important roles in the ability of OSBP and some ORPs to transfer cholesterol and phosphatidylserine between the ER and other organelle membranes.	Phosphatidylserines	113-131	oxysterol binding protein	Homo sapiens	66-70
32005660-2	2020	Here we determined the crystal structure of human VAT-1, a cytosolic soluble protein that was suggested to transfer phosphatidylserine, at 2.2 A resolution.	Phosphatidylserines	116-134	vesicle amine transport 1	Homo sapiens	50-55
32005660-3	2020	We found that VAT-1 transferred not only phosphatidylserine but also other acidic phospholipids between membranes in vitro.	Phosphatidylserines	41-59	vesicle amine transport 1	Homo sapiens	14-19
32195268-3	2020	This review focuses on the former, in which PS exposure on a subpopulation of platelets facilitates assembly of the intrinsic tenase and prothrombinase complexes, thereby accelerating thrombin generation on the activated platelet surface, contributing importantly to the hemostatic process.	Phosphatidylserines	44-46	coagulation factor II, thrombin	Homo sapiens	140-148
32140260-0	2020	2-Aminoethoxydiphenylborate (2-APB) inhibits release of phosphatidylserine-exposing extracellular vesicles from platelets.	Phosphatidylserines	56-74	arginyl aminopeptidase	Homo sapiens	31-34
32140260-8	2020	These data suggest that there is a further target of 2-APB, independent of cytosolic Ca2+ signalling, PS exposure and calpain activity, that is required for PS-exposing EV release.	Phosphatidylserines	102-104	arginyl aminopeptidase	Homo sapiens	55-58
32140260-8	2020	These data suggest that there is a further target of 2-APB, independent of cytosolic Ca2+ signalling, PS exposure and calpain activity, that is required for PS-exposing EV release.	Phosphatidylserines	157-159	arginyl aminopeptidase	Homo sapiens	55-58
32140260-10	2020	Identifying the target of 2-APB, DPBA and DP3A may provide a new way to inhibit PS-exposing EV release from activated platelets and inhibit their contribution to thrombosis and inflammation.	Phosphatidylserines	80-82	arginyl aminopeptidase	Homo sapiens	28-31
31848194-6	2020	Mechanistically, phosphatidylserine (PtdSer) engagement promoted phosphorylation of Tim-3 which then competed with PI3K p110 to bind p85, inhibiting downstream Akt/mTORC1 signalling and resulting in malfunctioning of both NK cell subsets.	Phosphatidylserines	17-35	hepatitis A virus cellular receptor 2	Homo sapiens	84-89
31848194-6	2020	Mechanistically, phosphatidylserine (PtdSer) engagement promoted phosphorylation of Tim-3 which then competed with PI3K p110 to bind p85, inhibiting downstream Akt/mTORC1 signalling and resulting in malfunctioning of both NK cell subsets.	Phosphatidylserines	17-35	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	133-136
31848194-6	2020	Mechanistically, phosphatidylserine (PtdSer) engagement promoted phosphorylation of Tim-3 which then competed with PI3K p110 to bind p85, inhibiting downstream Akt/mTORC1 signalling and resulting in malfunctioning of both NK cell subsets.	Phosphatidylserines	17-35	AKT serine/threonine kinase 1	Homo sapiens	160-163
31848194-6	2020	Mechanistically, phosphatidylserine (PtdSer) engagement promoted phosphorylation of Tim-3 which then competed with PI3K p110 to bind p85, inhibiting downstream Akt/mTORC1 signalling and resulting in malfunctioning of both NK cell subsets.	Phosphatidylserines	17-35	CREB regulated transcription coactivator 1	Mus musculus	164-170
31848194-6	2020	Mechanistically, phosphatidylserine (PtdSer) engagement promoted phosphorylation of Tim-3 which then competed with PI3K p110 to bind p85, inhibiting downstream Akt/mTORC1 signalling and resulting in malfunctioning of both NK cell subsets.	Phosphatidylserines	37-43	hepatitis A virus cellular receptor 2	Homo sapiens	84-89
31848194-6	2020	Mechanistically, phosphatidylserine (PtdSer) engagement promoted phosphorylation of Tim-3 which then competed with PI3K p110 to bind p85, inhibiting downstream Akt/mTORC1 signalling and resulting in malfunctioning of both NK cell subsets.	Phosphatidylserines	37-43	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	133-136
31848194-6	2020	Mechanistically, phosphatidylserine (PtdSer) engagement promoted phosphorylation of Tim-3 which then competed with PI3K p110 to bind p85, inhibiting downstream Akt/mTORC1 signalling and resulting in malfunctioning of both NK cell subsets.	Phosphatidylserines	37-43	AKT serine/threonine kinase 1	Homo sapiens	160-163
31848194-6	2020	Mechanistically, phosphatidylserine (PtdSer) engagement promoted phosphorylation of Tim-3 which then competed with PI3K p110 to bind p85, inhibiting downstream Akt/mTORC1 signalling and resulting in malfunctioning of both NK cell subsets.	Phosphatidylserines	37-43	CREB regulated transcription coactivator 1	Mus musculus	164-170
32114386-9	2020	Notably, the complementary roles of CLS plasma and thrombin-activated PLTs were required for NET formation and subsequent PS exposure.	Phosphatidylserines	122-124	coagulation factor II, thrombin	Homo sapiens	51-59
30796508-2	2020	The present study aimed to explore the effect of phosphatidylserine- and piperine-containing curcumin phytosomes on a large number of metabolic parameters related to insulin resistance, in the context of a randomized double-blind placebo-controlled trial involving 80 overweight subjects with suboptimal fasting plasma glucose.	Phosphatidylserines	49-67	insulin	Homo sapiens	166-173
31911118-5	2020	The processes include the generation of "Find-Me" signals (such as adenosine triphosphate/uridine triphosphate, fractalkine, lysophosphatidylcholine, and sphingosine-1-phosphate) for the recruitment of viable macrophages, generation of the "Eat-Me" signals (for example, phosphatidylserine) for the engulfment process, and, finally, release of anti-inflammatory mediators (including transforming factor beta and interleukin-10) as a tolerance-enhancing and an anti-inflammatory response, and for the motile behavior of the apoptotic cell.	Phosphatidylserines	271-289	interleukin 10	Homo sapiens	412-426
31945260-7	2020	From multivariate analyses adjusted for age, sex, and BMI, several phospholipids containing long chain PUFA with 20-22 carbons (phosphatidylcholines, phosphatidylethanolamines, phosphatidylinositols, and a phosphatidylserine), were positively associated with ferritin and the ferritin/adiponectin ratio.	Phosphatidylserines	206-224	pumilio RNA binding family member 3	Homo sapiens	103-107
31732320-3	2020	However, recent evidence that TIM-1 can restrict viral release reveals a new role for these PS receptors.	Phosphatidylserines	92-94	hepatitis A virus cellular receptor 1	Homo sapiens	30-35
32110987-6	2020	Furthermore, in vivo studies showed that PS externalization in cortical neurons induced by artificial cerebral ischemia-reperfusion was reduced in TRPC5 knockout mice compared to wild-type mice, and that the percentage of apoptotic neurons was also lower in TRPC5 knockout mice than in wild-type mice.	Phosphatidylserines	41-43	transient receptor potential cation channel, subfamily C, member 5	Mus musculus	147-152
32110987-6	2020	Furthermore, in vivo studies showed that PS externalization in cortical neurons induced by artificial cerebral ischemia-reperfusion was reduced in TRPC5 knockout mice compared to wild-type mice, and that the percentage of apoptotic neurons was also lower in TRPC5 knockout mice than in wild-type mice.	Phosphatidylserines	41-43	transient receptor potential cation channel, subfamily C, member 5	Mus musculus	258-263
32084238-11	2020	CONCLUSIONS: Irradiation renders tumor and tumor vascular cells procoagulant by PS upregulation on their outer surface and radiotherapy can significantly improve the therapeutic antitumor efficacy of tTF-NGR in the xenograft model used.	Phosphatidylserines	80-82	reticulon 4 receptor	Homo sapiens	204-207
31325355-12	2020	NETs triggered PS-positive microparticle release and PS exposure on platelets and endothelial cells partially through TLR2 and TLR4, converting them to a procoagulant phenotype.	Phosphatidylserines	15-17	toll like receptor 2	Homo sapiens	118-122
31325355-12	2020	NETs triggered PS-positive microparticle release and PS exposure on platelets and endothelial cells partially through TLR2 and TLR4, converting them to a procoagulant phenotype.	Phosphatidylserines	15-17	toll like receptor 4	Homo sapiens	127-131
31786280-5	2020	Point mutations altering entry gate residues in the first (Q209A) and fourth (S457Q) transmembrane segments of Neo1, where phospholipid substrate would initially be selected, disrupt PS and PE membrane asymmetry, but do not perturb growth of cells.	Phosphatidylserines	183-185	putative aminophospholipid-translocating P4-type ATPase NEO1	Saccharomyces cerevisiae S288C	111-115
31786280-7	2020	We also identified a gain-of-function mutation in the second transmembrane segment of Neo1 (Neo1[Y222S]), predicted to help form the entry gate, that substantially enhances Neo1"s ability to replace the function of a well characterized phospholipid flippase, Drs2, in establishing PS and PE asymmetry.	Phosphatidylserines	281-283	putative aminophospholipid-translocating P4-type ATPase NEO1	Saccharomyces cerevisiae S288C	86-90
31786280-7	2020	We also identified a gain-of-function mutation in the second transmembrane segment of Neo1 (Neo1[Y222S]), predicted to help form the entry gate, that substantially enhances Neo1"s ability to replace the function of a well characterized phospholipid flippase, Drs2, in establishing PS and PE asymmetry.	Phosphatidylserines	281-283	putative aminophospholipid-translocating P4-type ATPase NEO1	Saccharomyces cerevisiae S288C	92-96
31786280-7	2020	We also identified a gain-of-function mutation in the second transmembrane segment of Neo1 (Neo1[Y222S]), predicted to help form the entry gate, that substantially enhances Neo1"s ability to replace the function of a well characterized phospholipid flippase, Drs2, in establishing PS and PE asymmetry.	Phosphatidylserines	281-283	putative aminophospholipid-translocating P4-type ATPase NEO1	Saccharomyces cerevisiae S288C	92-96
31786280-7	2020	We also identified a gain-of-function mutation in the second transmembrane segment of Neo1 (Neo1[Y222S]), predicted to help form the entry gate, that substantially enhances Neo1"s ability to replace the function of a well characterized phospholipid flippase, Drs2, in establishing PS and PE asymmetry.	Phosphatidylserines	281-283	aminophospholipid-translocating P4-type ATPase DRS2	Saccharomyces cerevisiae S288C	259-263
31816323-2	2020	Phosphatidylserine (PS) lipids in the inner leaflet of the cell membrane are externalized and become exposed in cholesterol (CHOL)-rich membrane raft-like microdomain during apoptosis and co-localized with cell surface CRT.	Phosphatidylserines	0-18	calreticulin	Homo sapiens	219-222
31816323-2	2020	Phosphatidylserine (PS) lipids in the inner leaflet of the cell membrane are externalized and become exposed in cholesterol (CHOL)-rich membrane raft-like microdomain during apoptosis and co-localized with cell surface CRT.	Phosphatidylserines	20-22	calreticulin	Homo sapiens	219-222
31664482-2	2020	A complex of the ligands Protein S (PROS1) or Growth Arrest-Specific 6 (GAS6) with apoptotic phosphatidylserine activates the TAM receptors.	Phosphatidylserines	93-111	growth arrest specific 6	Homo sapiens	46-70
31664482-2	2020	A complex of the ligands Protein S (PROS1) or Growth Arrest-Specific 6 (GAS6) with apoptotic phosphatidylserine activates the TAM receptors.	Phosphatidylserines	93-111	growth arrest specific 6	Homo sapiens	72-76
31642515-3	2020	Here we describe expression of the PS-binding protein Annexin-V (ANXA5) in CD4+ CD25hi Treg on the mRNA and protein level.	Phosphatidylserines	35-37	annexin A5	Homo sapiens	54-63
31642515-3	2020	Here we describe expression of the PS-binding protein Annexin-V (ANXA5) in CD4+ CD25hi Treg on the mRNA and protein level.	Phosphatidylserines	35-37	annexin A5	Homo sapiens	65-70
31642515-3	2020	Here we describe expression of the PS-binding protein Annexin-V (ANXA5) in CD4+ CD25hi Treg on the mRNA and protein level.	Phosphatidylserines	35-37	CD4 molecule	Homo sapiens	75-78
31642515-3	2020	Here we describe expression of the PS-binding protein Annexin-V (ANXA5) in CD4+ CD25hi Treg on the mRNA and protein level.	Phosphatidylserines	35-37	interleukin 2 receptor subunit alpha	Homo sapiens	80-84
31642515-5	2020	In vitro, ANXA5+ Treg cells showed enhanced adhesion to PS+ endothelial cells.	Phosphatidylserines	56-58	annexin A5	Homo sapiens	10-15
31642515-6	2020	Stimulated by anti-CD3 and PS+ syngeneic APC CD4+ ANXA5+ T-cells expanded in the absence of exogenous IL-2.	Phosphatidylserines	27-29	CD4 molecule	Homo sapiens	45-48
31642515-6	2020	Stimulated by anti-CD3 and PS+ syngeneic APC CD4+ ANXA5+ T-cells expanded in the absence of exogenous IL-2.	Phosphatidylserines	27-29	annexin A5	Homo sapiens	50-55
31862710-3	2020	An Eros-null mouse T cell line lost the ability to expose PtdSer, to scramble phospholipids, and to internalize a dye YO-PRO-1 and Ca2+ ions.	Phosphatidylserines	58-64	cytochrome b-245 chaperone 1	Homo sapiens	3-7
31680426-10	2020	LR12 dampened TF activity through the decrease of PtdSer exposure, leading to a reduction of thrombin generation.	Phosphatidylserines	50-56	coagulation factor III, tissue factor	Homo sapiens	14-16
31995754-0	2020	Critical Role of Lipid Scramblase TMEM16F in Phosphatidylserine Exposure and Repair of Plasma Membrane after Pore Formation.	Phosphatidylserines	45-63	anoctamin 6	Mus musculus	34-41
31973069-6	2020	Consistently, among the major phospholipids, NCS-1 preferentially interacts with phosphatidylserine and phosphatidylinositol with micromolar affinity and the interaction with the former is inhibited upon mutating of N-terminal lysines of the protein.	Phosphatidylserines	81-99	neuronal calcium sensor 1	Homo sapiens	45-50
31712393-2	2020	XKR8 is a plasma membrane protein that scrambles phospholipids in response to apoptotic signals, exposing phosphatidylserine (PtdSer).	Phosphatidylserines	106-124	X-linked Kx blood group related 8	Mus musculus	0-4
31712393-2	2020	XKR8 is a plasma membrane protein that scrambles phospholipids in response to apoptotic signals, exposing phosphatidylserine (PtdSer).	Phosphatidylserines	126-132	X-linked Kx blood group related 8	Mus musculus	0-4
31712393-5	2020	Consistent with the hypothesis that PtdSer functions as an "eat me" signal to phagocytes, cells expressing phosphatidylserine receptor TIM4 and MER tyrosine kinase receptor efficiently engulfed apoptotic wild-type male germ cells, but not Xkr8-/- germ cells.	Phosphatidylserines	36-42	T cell immunoglobulin and mucin domain containing 4	Mus musculus	135-139
31712393-5	2020	Consistent with the hypothesis that PtdSer functions as an "eat me" signal to phagocytes, cells expressing phosphatidylserine receptor TIM4 and MER tyrosine kinase receptor efficiently engulfed apoptotic wild-type male germ cells, but not Xkr8-/- germ cells.	Phosphatidylserines	36-42	MER proto-oncogene tyrosine kinase	Mus musculus	144-147
31712393-5	2020	Consistent with the hypothesis that PtdSer functions as an "eat me" signal to phagocytes, cells expressing phosphatidylserine receptor TIM4 and MER tyrosine kinase receptor efficiently engulfed apoptotic wild-type male germ cells, but not Xkr8-/- germ cells.	Phosphatidylserines	107-125	T cell immunoglobulin and mucin domain containing 4	Mus musculus	135-139
31712393-5	2020	Consistent with the hypothesis that PtdSer functions as an "eat me" signal to phagocytes, cells expressing phosphatidylserine receptor TIM4 and MER tyrosine kinase receptor efficiently engulfed apoptotic wild-type male germ cells, but not Xkr8-/- germ cells.	Phosphatidylserines	107-125	X-linked Kx blood group related 8	Mus musculus	239-243
31712393-8	2020	These results indicate that XKR8-mediated PtdSer exposure is essential for the clearance of apoptotic germ cells by Sertoli cells.	Phosphatidylserines	42-48	X-linked Kx blood group related 8	Mus musculus	28-32
31653673-6	2020	Importantly, there is significantly more phosphatidylinositol-4-phosphate (PI(4)P) and less phosphatidylserine (PS) on LDs in ORP5-deficient cells than in normal cells.	Phosphatidylserines	92-110	oxysterol binding protein like 5	Homo sapiens	126-130
31653673-6	2020	Importantly, there is significantly more phosphatidylinositol-4-phosphate (PI(4)P) and less phosphatidylserine (PS) on LDs in ORP5-deficient cells than in normal cells.	Phosphatidylserines	112-114	oxysterol binding protein like 5	Homo sapiens	126-130
31653673-8	2020	Our results thus demonstrate the existence of PI(4)P on LDs and suggest that LD-associated PI(4)P may be primarily used by ORP5 to deliver PS to LDs.	Phosphatidylserines	139-141	oxysterol binding protein like 5	Homo sapiens	123-127
31868890-5	2020	Cell Biol.https://doi.org/10.1083/jcb.201905162) show that the lipid transfer protein ORP5 functions at ER-LD contact sites, regulating lipid droplet levels of phosphatidylserine and phosphatidylinositol-4-phosphate.	Phosphatidylserines	160-178	oxysterol binding protein like 5	Homo sapiens	86-90
31587282-4	2020	Furthermore, our results show that the PS-mediated effect on the fission-pore duration is Ca2+ -dependent and abolished in the absence of synaptotagmin 1 (Syt1), implying that Syt1 is necessary for the stimulatory role of PS in vesicle fission during CME.	Phosphatidylserines	39-41	synaptotagmin I	Mus musculus	138-153
31587282-4	2020	Furthermore, our results show that the PS-mediated effect on the fission-pore duration is Ca2+ -dependent and abolished in the absence of synaptotagmin 1 (Syt1), implying that Syt1 is necessary for the stimulatory role of PS in vesicle fission during CME.	Phosphatidylserines	39-41	synaptotagmin I	Mus musculus	155-159
31587282-4	2020	Furthermore, our results show that the PS-mediated effect on the fission-pore duration is Ca2+ -dependent and abolished in the absence of synaptotagmin 1 (Syt1), implying that Syt1 is necessary for the stimulatory role of PS in vesicle fission during CME.	Phosphatidylserines	39-41	synaptotagmin I	Mus musculus	176-180
31587282-4	2020	Furthermore, our results show that the PS-mediated effect on the fission-pore duration is Ca2+ -dependent and abolished in the absence of synaptotagmin 1 (Syt1), implying that Syt1 is necessary for the stimulatory role of PS in vesicle fission during CME.	Phosphatidylserines	222-224	synaptotagmin I	Mus musculus	176-180
31754972-5	2020	Furthermore, we have shown for the first time that both dimeric and hemi-MPO lead to phosphatidylserine (PS) exposure on the outer leaflet of RBC membrane.	Phosphatidylserines	85-103	myeloperoxidase	Homo sapiens	73-76
31754972-5	2020	Furthermore, we have shown for the first time that both dimeric and hemi-MPO lead to phosphatidylserine (PS) exposure on the outer leaflet of RBC membrane.	Phosphatidylserines	105-107	myeloperoxidase	Homo sapiens	73-76
31669855-3	2020	Thus, we prepared small-sized PS- and PG-loaded liposomes exhibiting narrow distribution, and additionally studied the impact of liposome-pegylation on the reduction of the TNFalpha-production caused by the PS- and PG-liposomes.	Phosphatidylserines	207-209	tumor necrosis factor	Mus musculus	173-181
30836803-14	2020	VWD3 platelets seem to compensate for the FVIII-associated reduction in TG by their exposure of P-selectin and phosphatidylserine.	Phosphatidylserines	111-129	coagulation factor VIII	Homo sapiens	42-47
31869331-5	2019	Importantly, reducing PS transport from the ER to PM by loss of PI4KIIIalpha partially rescues the mitochondrial defects of pss RNAi.	Phosphatidylserines	22-24	Phosphatidylinositol 4-kinase III alpha	Drosophila melanogaster	64-76
31836429-0	2019	Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure.	Phosphatidylserines	84-102	gasdermin D	Homo sapiens	62-73
31793433-4	2019	Using a phosphatidylserine binding domain and an RGD motif, MFG-E8 helps target HIV-1 VLPs to alphav integrin bearing SMs.	Phosphatidylserines	8-26	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	60-66
31397519-1	2019	ATP8A2 is a P4-ATPase (adenosine triphosphate) that actively flips phosphatidylserine and phosphatidylethanolamine from the exoplasmic to the cytoplasmic leaflet of cell membranes to generate and maintain phospholipid asymmetry.	Phosphatidylserines	67-85	ATPase phospholipid transporting 8A2	Homo sapiens	0-6
31397519-1	2019	ATP8A2 is a P4-ATPase (adenosine triphosphate) that actively flips phosphatidylserine and phosphatidylethanolamine from the exoplasmic to the cytoplasmic leaflet of cell membranes to generate and maintain phospholipid asymmetry.	Phosphatidylserines	67-85	dynein axonemal heavy chain 8	Homo sapiens	15-21
31446108-7	2019	Under optimized conditions and the phosphatidylserine (PS) yield reached 95.5% within 40 min at 45  C. The immobilized PLD exhibited not only better storage stability and but also resistance to pH and thermal inactivation than free PLD.	Phosphatidylserines	35-53	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	119-122
31446108-7	2019	Under optimized conditions and the phosphatidylserine (PS) yield reached 95.5% within 40 min at 45  C. The immobilized PLD exhibited not only better storage stability and but also resistance to pH and thermal inactivation than free PLD.	Phosphatidylserines	35-53	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	232-235
31446108-7	2019	Under optimized conditions and the phosphatidylserine (PS) yield reached 95.5% within 40 min at 45  C. The immobilized PLD exhibited not only better storage stability and but also resistance to pH and thermal inactivation than free PLD.	Phosphatidylserines	55-57	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	119-122
31446108-7	2019	Under optimized conditions and the phosphatidylserine (PS) yield reached 95.5% within 40 min at 45  C. The immobilized PLD exhibited not only better storage stability and but also resistance to pH and thermal inactivation than free PLD.	Phosphatidylserines	55-57	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	232-235
31775787-2	2019	This review will focus on PtdSer as a cofactor required for stimulating TYRO3, AXL and MERTK - comprising the TAM family of receptor tyrosine kinases by their ligands Protein S (PROS1) and growth-arrest-specific 6 (GAS6) in inflammation and cancer.	Phosphatidylserines	26-32	TYRO3 protein tyrosine kinase	Homo sapiens	72-77
31775787-2	2019	This review will focus on PtdSer as a cofactor required for stimulating TYRO3, AXL and MERTK - comprising the TAM family of receptor tyrosine kinases by their ligands Protein S (PROS1) and growth-arrest-specific 6 (GAS6) in inflammation and cancer.	Phosphatidylserines	26-32	AXL receptor tyrosine kinase	Homo sapiens	79-82
31775787-2	2019	This review will focus on PtdSer as a cofactor required for stimulating TYRO3, AXL and MERTK - comprising the TAM family of receptor tyrosine kinases by their ligands Protein S (PROS1) and growth-arrest-specific 6 (GAS6) in inflammation and cancer.	Phosphatidylserines	26-32	MER proto-oncogene, tyrosine kinase	Homo sapiens	87-92
31775787-2	2019	This review will focus on PtdSer as a cofactor required for stimulating TYRO3, AXL and MERTK - comprising the TAM family of receptor tyrosine kinases by their ligands Protein S (PROS1) and growth-arrest-specific 6 (GAS6) in inflammation and cancer.	Phosphatidylserines	26-32	protein S	Homo sapiens	178-183
31775787-2	2019	This review will focus on PtdSer as a cofactor required for stimulating TYRO3, AXL and MERTK - comprising the TAM family of receptor tyrosine kinases by their ligands Protein S (PROS1) and growth-arrest-specific 6 (GAS6) in inflammation and cancer.	Phosphatidylserines	26-32	growth arrest specific 6	Homo sapiens	189-213
31775787-2	2019	This review will focus on PtdSer as a cofactor required for stimulating TYRO3, AXL and MERTK - comprising the TAM family of receptor tyrosine kinases by their ligands Protein S (PROS1) and growth-arrest-specific 6 (GAS6) in inflammation and cancer.	Phosphatidylserines	26-32	growth arrest specific 6	Homo sapiens	215-219
31699964-7	2019	Notably, PS exposure required cellular vacuolization induced by defects in endocytic trafficking and was suppressed by the inhibition of PP2A and shedding of Annexin V-positive subcellular particles.	Phosphatidylserines	9-11	protein phosphatase 2 phosphatase activator	Homo sapiens	137-141
31699964-7	2019	Notably, PS exposure required cellular vacuolization induced by defects in endocytic trafficking and was suppressed by the inhibition of PP2A and shedding of Annexin V-positive subcellular particles.	Phosphatidylserines	9-11	annexin A5	Homo sapiens	158-167
31875083-6	2019	The exhibition of phosphatidylserine was analyzed with the Annexin-V Fluorescein isothiocyanate flow cytometry (FITC) method.	Phosphatidylserines	18-36	annexin A5	Homo sapiens	59-68
28613115-4	2019	We recently reported that phosphatidylserine (PS), a membrane phospholipid component, played a pivotal role in the physical interaction between Rho1 and Pkc1 as well as the activation of the Pkc1-Mpk1 MAP kinase cascade.	Phosphatidylserines	26-44	Rho family GTPase RHO1	Saccharomyces cerevisiae S288C	144-148
28613115-4	2019	We recently reported that phosphatidylserine (PS), a membrane phospholipid component, played a pivotal role in the physical interaction between Rho1 and Pkc1 as well as the activation of the Pkc1-Mpk1 MAP kinase cascade.	Phosphatidylserines	26-44	protein kinase C	Saccharomyces cerevisiae S288C	153-157
28613115-4	2019	We recently reported that phosphatidylserine (PS), a membrane phospholipid component, played a pivotal role in the physical interaction between Rho1 and Pkc1 as well as the activation of the Pkc1-Mpk1 MAP kinase cascade.	Phosphatidylserines	26-44	protein kinase C	Saccharomyces cerevisiae S288C	191-195
28613115-4	2019	We recently reported that phosphatidylserine (PS), a membrane phospholipid component, played a pivotal role in the physical interaction between Rho1 and Pkc1 as well as the activation of the Pkc1-Mpk1 MAP kinase cascade.	Phosphatidylserines	46-48	Rho family GTPase RHO1	Saccharomyces cerevisiae S288C	144-148
28613115-4	2019	We recently reported that phosphatidylserine (PS), a membrane phospholipid component, played a pivotal role in the physical interaction between Rho1 and Pkc1 as well as the activation of the Pkc1-Mpk1 MAP kinase cascade.	Phosphatidylserines	46-48	protein kinase C	Saccharomyces cerevisiae S288C	153-157
28613115-4	2019	We recently reported that phosphatidylserine (PS), a membrane phospholipid component, played a pivotal role in the physical interaction between Rho1 and Pkc1 as well as the activation of the Pkc1-Mpk1 MAP kinase cascade.	Phosphatidylserines	46-48	protein kinase C	Saccharomyces cerevisiae S288C	191-195
31393494-8	2019	Furthermore, the annexin V-FITC staining method strongly suggested the presence of phosphatidylserine (PS) on the outer membrane of the treated cells, which is a hallmark of apoptosis.	Phosphatidylserines	83-101	annexin A5	Homo sapiens	17-26
31393494-8	2019	Furthermore, the annexin V-FITC staining method strongly suggested the presence of phosphatidylserine (PS) on the outer membrane of the treated cells, which is a hallmark of apoptosis.	Phosphatidylserines	103-105	annexin A5	Homo sapiens	17-26
31658639-5	2019	In particular, salt bridges between Arg43, Arg46 and polar heads of phosphatidylserine lipids are necessary to enhance the myristoyl hydrophobic packing in the Rec-GRK1 assembly.	Phosphatidylserines	68-86	recoverin	Homo sapiens	160-163
31658639-5	2019	In particular, salt bridges between Arg43, Arg46 and polar heads of phosphatidylserine lipids are necessary to enhance the myristoyl hydrophobic packing in the Rec-GRK1 assembly.	Phosphatidylserines	68-86	G protein-coupled receptor kinase 1	Homo sapiens	164-168
31601855-4	2019	We demonstrate that phosphatidylserine maintains PDK1 in an inactive conformation.	Phosphatidylserines	20-38	pyruvate dehydrogenase kinase 1	Homo sapiens	49-53
31302248-1	2019	Yeast phosphatidylinositol transfer protein (PITP) Pdr17 is an essential component of the complex required for decarboxylation of phosphatidylserine (PS) to phosphatidylethanolamine (PE) at a non-mitochondrial location.	Phosphatidylserines	130-148	phosphatidylinositol transporter	Saccharomyces cerevisiae S288C	51-56
31302248-1	2019	Yeast phosphatidylinositol transfer protein (PITP) Pdr17 is an essential component of the complex required for decarboxylation of phosphatidylserine (PS) to phosphatidylethanolamine (PE) at a non-mitochondrial location.	Phosphatidylserines	150-152	phosphatidylinositol transporter	Saccharomyces cerevisiae S288C	51-56
31302248-3	2019	We generated a Pdr17E237A, K269A mutant protein to better understand the mechanism by which Pdr17p participates in the processes connected to the decarboxylation of PS to PE.	Phosphatidylserines	165-167	phosphatidylinositol transporter	Saccharomyces cerevisiae S288C	92-98
30819915-2	2019	It has been documented that deficiency of Tmem30a led to exposure of phosphatidylserine.	Phosphatidylserines	69-87	transmembrane protein 30A	Mus musculus	42-49
31575859-5	2019	On the oocyte, phosphatidylserine recognition receptors BAI1, CD36, Tim-4, and Mer-TK contribute to fertilization.	Phosphatidylserines	15-33	adhesion G protein-coupled receptor B1	Homo sapiens	56-60
31280326-7	2019	Using flow cytometry, phosphatidylserine exposure at the cell surface was quantified from annexin V binding, cell volume from forward scatter, [Ca2+]i from Fluo3 fluorescence, ROS from DCFDA-dependent fluorescence, and ceramide abundance utilizing specific antibodies.	Phosphatidylserines	22-40	annexin A5	Homo sapiens	90-99
31608052-9	2019	LPR-derived parasitized erythroid cells exhibited less externalization of phosphatidylserine (PS), and phagocytosis by macrophages was impaired.	Phosphatidylserines	74-92	Fas (TNF receptor superfamily member 6)	Mus musculus	0-3
31608052-9	2019	LPR-derived parasitized erythroid cells exhibited less externalization of phosphatidylserine (PS), and phagocytosis by macrophages was impaired.	Phosphatidylserines	94-96	Fas (TNF receptor superfamily member 6)	Mus musculus	0-3
31402097-4	2019	In real-time assays, we find that unsaturated phosphatidylserine (PS) and sterols, both Osh protein ligands, synergistically stimulate phosphatidylinositol 4-phosphate 5-kinase (PIP5K) activity.	Phosphatidylserines	66-68	phosphatidylinositol-5-phosphate 4-kinase type 2 gamma	Homo sapiens	135-176
31402097-4	2019	In real-time assays, we find that unsaturated phosphatidylserine (PS) and sterols, both Osh protein ligands, synergistically stimulate phosphatidylinositol 4-phosphate 5-kinase (PIP5K) activity.	Phosphatidylserines	66-68	phosphatidylinositol-5-phosphate 4-kinase type 2 gamma	Homo sapiens	178-183
31402097-6	2019	Moreover, using in vivo imaging approaches and molecular dynamics simulations, we show that Osh protein-mediated unsaturated PI4P and PS membrane lipid organization is sensed by the PIP5K specificity loop.	Phosphatidylserines	134-136	phosphatidylinositol-5-phosphate 4-kinase type 2 gamma	Homo sapiens	182-187
31371488-9	2019	These results suggest that the ATP11C-b regulates PS distribution in distinct regions of the plasma membrane in polarized cells.	Phosphatidylserines	50-52	ATPase phospholipid transporting 11C	Homo sapiens	31-37
31477717-2	2019	Osh6p and Osh7p are yeast LTPs that transfer phosphatidylserine (PS) from the endoplasmic reticulum (ER) to the plasma membrane (PM) via PS/phosphatidylinositol-4-phosphate (PI4P) exchange cycles.	Phosphatidylserines	45-63	oxysterol-binding protein OSH6	Saccharomyces cerevisiae S288C	0-5
31477717-2	2019	Osh6p and Osh7p are yeast LTPs that transfer phosphatidylserine (PS) from the endoplasmic reticulum (ER) to the plasma membrane (PM) via PS/phosphatidylinositol-4-phosphate (PI4P) exchange cycles.	Phosphatidylserines	45-63	oxysterol-binding protein related protein OSH7	Saccharomyces cerevisiae S288C	10-15
31477717-2	2019	Osh6p and Osh7p are yeast LTPs that transfer phosphatidylserine (PS) from the endoplasmic reticulum (ER) to the plasma membrane (PM) via PS/phosphatidylinositol-4-phosphate (PI4P) exchange cycles.	Phosphatidylserines	65-67	oxysterol-binding protein OSH6	Saccharomyces cerevisiae S288C	0-5
31477717-2	2019	Osh6p and Osh7p are yeast LTPs that transfer phosphatidylserine (PS) from the endoplasmic reticulum (ER) to the plasma membrane (PM) via PS/phosphatidylinositol-4-phosphate (PI4P) exchange cycles.	Phosphatidylserines	65-67	oxysterol-binding protein related protein OSH7	Saccharomyces cerevisiae S288C	10-15
31477717-2	2019	Osh6p and Osh7p are yeast LTPs that transfer phosphatidylserine (PS) from the endoplasmic reticulum (ER) to the plasma membrane (PM) via PS/phosphatidylinositol-4-phosphate (PI4P) exchange cycles.	Phosphatidylserines	137-139	oxysterol-binding protein OSH6	Saccharomyces cerevisiae S288C	0-5
31477717-2	2019	Osh6p and Osh7p are yeast LTPs that transfer phosphatidylserine (PS) from the endoplasmic reticulum (ER) to the plasma membrane (PM) via PS/phosphatidylinositol-4-phosphate (PI4P) exchange cycles.	Phosphatidylserines	137-139	oxysterol-binding protein related protein OSH7	Saccharomyces cerevisiae S288C	10-15
31054951-0	2019	Oxidized phosphatidylserine mitigates LPS-triggered macrophage inflammatory status through modulation of JNK and NF-kB signaling cascades.	Phosphatidylserines	9-27	mitogen-activated protein kinase 8	Homo sapiens	105-108
31451509-2	2019	We recently showed that the KRAS C-terminal membrane anchor exhibits exquisite lipid-binding specificity for select species of phosphatidylserine (PtdSer).	Phosphatidylserines	127-145	KRAS proto-oncogene, GTPase	Homo sapiens	28-32
31339036-6	2019	We find that KRAS4b binds significantly tighter to Nanodiscs containing PIP2 but that at any level of binding saturation of KRAS4b, both 30% PS and 10% PIP2 containing Nanodiscs display similar rotational correlation times.	Phosphatidylserines	141-143	KRAS proto-oncogene, GTPase	Homo sapiens	13-19
31263038-9	2019	In addition, PS binding motif was responsible for Tim-4-mediated AMPKalpha and LKB1 interaction.	Phosphatidylserines	13-15	T cell immunoglobulin and mucin domain containing 4	Mus musculus	50-55
31263038-9	2019	In addition, PS binding motif was responsible for Tim-4-mediated AMPKalpha and LKB1 interaction.	Phosphatidylserines	13-15	serine/threonine kinase 11	Mus musculus	79-83
31175934-4	2019	In this clearance system, integrin alphanubeta3/TAM receptors with bridging molecules and CR3 on microglia are essential for recognition of phosphatidylserine (PS)-exposed and C1q/C3-tagged focal synaptic compartments, respectively.	Phosphatidylserines	140-158	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	90-93
31175934-4	2019	In this clearance system, integrin alphanubeta3/TAM receptors with bridging molecules and CR3 on microglia are essential for recognition of phosphatidylserine (PS)-exposed and C1q/C3-tagged focal synaptic compartments, respectively.	Phosphatidylserines	160-162	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	90-93
31175934-5	2019	Caspase-3 plays pivotal roles in both synaptic PS exposure and C1q deposition.	Phosphatidylserines	47-49	caspase 3	Homo sapiens	0-9
31217278-4	2019	PS exposure and necroptosis were significant after 6- and 24-h treatments with IFN-gamma, respectively.	Phosphatidylserines	0-2	interferon gamma	Homo sapiens	79-88
31217278-9	2019	Therefore, PS exposure mediated by RIPK3-activated MLKL oligomers was induced by a treatment with IFN-gamma for a significant interval of time before the induction of necroptosis by membrane rupture.	Phosphatidylserines	11-13	receptor interacting serine/threonine kinase 3	Homo sapiens	35-40
31217278-9	2019	Therefore, PS exposure mediated by RIPK3-activated MLKL oligomers was induced by a treatment with IFN-gamma for a significant interval of time before the induction of necroptosis by membrane rupture.	Phosphatidylserines	11-13	mixed lineage kinase domain like pseudokinase	Homo sapiens	51-55
31217278-9	2019	Therefore, PS exposure mediated by RIPK3-activated MLKL oligomers was induced by a treatment with IFN-gamma for a significant interval of time before the induction of necroptosis by membrane rupture.	Phosphatidylserines	11-13	interferon gamma	Homo sapiens	98-107
31078025-7	2019	Flow cytometry was utilized to detect phosphatidylserine (PS) exposure by annexin-V binding, intracellular Ca2+ by Fluo-3/AM fluorescence, and oxidative stress by 2-,7-dichlorodihydrofluorescin diacetate (DCFH2-DA).	Phosphatidylserines	58-60	annexin A5	Homo sapiens	74-83
31175530-13	2019	The increase in TF activity was abolished by annexin V indicating that PS was required.	Phosphatidylserines	71-73	annexin A5	Homo sapiens	45-54
31365873-4	2019	We provide evidence that contact between externalized phosphatidylserine (PS) on OS tips and apical RPE receptors activates Akt, linking phagocytosis with glucose transport to photoreceptors for new OS synthesis.	Phosphatidylserines	54-72	AKT serine/threonine kinase 1	Homo sapiens	124-127
31365873-4	2019	We provide evidence that contact between externalized phosphatidylserine (PS) on OS tips and apical RPE receptors activates Akt, linking phagocytosis with glucose transport to photoreceptors for new OS synthesis.	Phosphatidylserines	74-76	AKT serine/threonine kinase 1	Homo sapiens	124-127
31296567-4	2019	The lipid-anchored K-Ras form nanoclusters selectively enriched with specific phospholipids, such as phosphatidylserine (PS), for efficient effector recruitment and activation.	Phosphatidylserines	101-119	KRAS proto-oncogene, GTPase	Homo sapiens	19-24
31296567-4	2019	The lipid-anchored K-Ras form nanoclusters selectively enriched with specific phospholipids, such as phosphatidylserine (PS), for efficient effector recruitment and activation.	Phosphatidylserines	121-123	KRAS proto-oncogene, GTPase	Homo sapiens	19-24
31296567-9	2019	Depletion of endogenous PS abolishes K-Ras G12V PM curvature sensing.	Phosphatidylserines	24-26	KRAS proto-oncogene, GTPase	Homo sapiens	37-42
31296567-10	2019	In cells and synthetic bilayers, only mixed-chain PS species, but not other PS species tested, mediate K-Ras G12V membrane curvature sensing.	Phosphatidylserines	50-52	KRAS proto-oncogene, GTPase	Homo sapiens	103-108
31172440-4	2019	PS binding to the phosphatidylserine receptor (PSR) on immune cells initiates immunosuppressive pathways that can lead to immune evasion by cancer cells.	Phosphatidylserines	0-2	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	47-50
31172440-4	2019	PS binding to the phosphatidylserine receptor (PSR) on immune cells initiates immunosuppressive pathways that can lead to immune evasion by cancer cells.	Phosphatidylserines	0-2	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	18-45
31242184-1	2019	BACKGROUND: T cell immunoglobulin mucin domain-1 (TIM-1) is a phosphatidylserine (PS) receptor, mediating filovirus entry into cells through interactions with PS on virions.	Phosphatidylserines	82-84	hepatitis A virus cellular receptor 1	Mus musculus	50-55
31263574-7	2019	A combination of PS expression and mitochondrial depolarization induced by the PF4-containing immune complexes observed in a substantial fraction of platelets was considered as a sign of ongoing platelet death, as opposed to a subpopulation of activated live platelets with PS on the plasma membrane but normal DeltaPsim.	Phosphatidylserines	17-19	platelet factor 4	Homo sapiens	79-82
31263574-8	2019	Both activated and dying platelets treated with KKO/PF4 formed procoagulant extracellular microvesicles bearing PS on their surface.	Phosphatidylserines	112-114	platelet factor 4	Homo sapiens	52-55
30996093-8	2019	In addition, TMED10 was found to be crucial for virus-induced plasma membrane blebbing and phosphatidylserine-induced macropinocytosis, presumably by regulating the cell surface expression of the TAM receptor Axl.IMPORTANCE Poxviruses are large DNA viruses that can infect a wide range of host species.	Phosphatidylserines	91-109	transmembrane p24 trafficking protein 10	Homo sapiens	13-19
30996093-8	2019	In addition, TMED10 was found to be crucial for virus-induced plasma membrane blebbing and phosphatidylserine-induced macropinocytosis, presumably by regulating the cell surface expression of the TAM receptor Axl.IMPORTANCE Poxviruses are large DNA viruses that can infect a wide range of host species.	Phosphatidylserines	91-109	AXL receptor tyrosine kinase	Homo sapiens	209-212
30996093-16	2019	Additionally, we show that TMED10, previously not implicated in virus infections, facilitates virus uptake by modulating the cellular response to phosphatidylserine.	Phosphatidylserines	146-164	transmembrane p24 trafficking protein 10	Homo sapiens	27-33
30910165-9	2019	Phosphatidylserine contributes to tissue factor decryption, and western blotting revealed that the density of phosphatidylserine was reduced in the upper tissue factor band compared with the lower band.	Phosphatidylserines	0-18	coagulation factor III, tissue factor	Homo sapiens	34-47
30910165-9	2019	Phosphatidylserine contributes to tissue factor decryption, and western blotting revealed that the density of phosphatidylserine was reduced in the upper tissue factor band compared with the lower band.	Phosphatidylserines	0-18	coagulation factor III, tissue factor	Homo sapiens	154-167
30910165-9	2019	Phosphatidylserine contributes to tissue factor decryption, and western blotting revealed that the density of phosphatidylserine was reduced in the upper tissue factor band compared with the lower band.	Phosphatidylserines	110-128	coagulation factor III, tissue factor	Homo sapiens	154-167
29363381-1	2019	Magnetic activated cell sorting (MACS) with annexin V microbeads deselected apoptotic sperm with externalized phosphatidylserine (PS) residues on their surface and decrease chance of such sperm to be inseminated.	Phosphatidylserines	110-128	annexin A5	Homo sapiens	44-53
29363381-1	2019	Magnetic activated cell sorting (MACS) with annexin V microbeads deselected apoptotic sperm with externalized phosphatidylserine (PS) residues on their surface and decrease chance of such sperm to be inseminated.	Phosphatidylserines	130-132	annexin A5	Homo sapiens	44-53
30942445-2	2019	Myristoylated alanine-rich C-kinase substrate (MARCKS) is a 32 kDa intrinsically unstructured protein containing a polybasic (+13) effector domain (ED), which regulates its electrostatic sequestration of phospholipid phosphatidylinositol (4,5)-bisphosphate (PIP2), and its binding to phosphatidylserine, calcium/calmodulin, filamentous actin, while also serving as a nuclear localization sequence.	Phosphatidylserines	284-302	myristoylated alanine rich protein kinase C substrate	Homo sapiens	47-53
30861549-8	2019	To date, externalization of phosphatidylserine to the outer leaflet and thiol-disulphide exchange pathways that either turn on and off the allosteric disulphide bond in TF are shown to play a major role in regulating TF pro-coagulant activity on cell surfaces.	Phosphatidylserines	28-46	coagulation factor III, tissue factor	Homo sapiens	169-171
30861549-8	2019	To date, externalization of phosphatidylserine to the outer leaflet and thiol-disulphide exchange pathways that either turn on and off the allosteric disulphide bond in TF are shown to play a major role in regulating TF pro-coagulant activity on cell surfaces.	Phosphatidylserines	28-46	coagulation factor III, tissue factor	Homo sapiens	217-219
30794332-9	2019	Study 2 showed similar results in which platelets stored in citrate-free PAS-III benefited through better maintenance of glucose utilization with less lactate production, P-selectin expression, PS exposure, and ROS formation compared to citrate-containing PAS-III.	Phosphatidylserines	194-196	mucin 15, cell surface associated	Homo sapiens	73-80
31050338-8	2019	The DHPC-binding mode of the cPLA2alpha C2-domain, which differs from phosphatidylserine or phosphatidylinositol 4,5-bisphosphate binding by other C2-domains, expands and deepens knowledge of the lipid-binding mechanisms mediated by C2-domains.	Phosphatidylserines	70-88	phospholipase A2 group IVA	Homo sapiens	29-39
30890560-2	2019	Although nSMase2 has low basal activity, it is fully activated by phosphatidylserine (PS).	Phosphatidylserines	66-84	sphingomyelin phosphodiesterase 3	Homo sapiens	9-16
30890560-5	2019	In contrast to what we previously assumed, we demonstrate that PS binding at the N-terminal and juxtamembrane regions of nSMase2 rather acts as a conformational switch leading to interdomain interactions that are critical to enzyme activation.	Phosphatidylserines	63-65	sphingomyelin phosphodiesterase 3	Homo sapiens	121-128
31051106-6	2019	We demonstrate that Mfn2 binds phosphatidylserine (PS) and can specifically extract PS into membrane domains, favoring PS transfer to mitochondria and mitochondrial phosphatidylethanolamine (PE) synthesis.	Phosphatidylserines	31-49	mitofusin 2	Mus musculus	20-24
31051106-6	2019	We demonstrate that Mfn2 binds phosphatidylserine (PS) and can specifically extract PS into membrane domains, favoring PS transfer to mitochondria and mitochondrial phosphatidylethanolamine (PE) synthesis.	Phosphatidylserines	51-53	mitofusin 2	Mus musculus	20-24
31051106-6	2019	We demonstrate that Mfn2 binds phosphatidylserine (PS) and can specifically extract PS into membrane domains, favoring PS transfer to mitochondria and mitochondrial phosphatidylethanolamine (PE) synthesis.	Phosphatidylserines	84-86	mitofusin 2	Mus musculus	20-24
30630982-4	2019	There was also deposition of C3b on sickle red cell membranes, which is promoted locally by the exposure of phosphatidylserine.	Phosphatidylserines	108-126	endogenous retrovirus group K member 3	Homo sapiens	29-32
30880218-8	2019	Phosphatidylserine (PS) exposure was detected with Annexin-V-FITC, cell volume by forward scatter (FSC) of light, intracellular calcium with Fluo-3/AM, and reactive oxygen species with 2",7"-dichlorodihydrofluorescein diacetate (H2DCFDA).	Phosphatidylserines	0-18	annexin A5	Homo sapiens	51-60
30880218-8	2019	Phosphatidylserine (PS) exposure was detected with Annexin-V-FITC, cell volume by forward scatter (FSC) of light, intracellular calcium with Fluo-3/AM, and reactive oxygen species with 2",7"-dichlorodihydrofluorescein diacetate (H2DCFDA).	Phosphatidylserines	20-22	annexin A5	Homo sapiens	51-60
30803987-2	2019	Here, using genetic engineering, we coupled the disintegrin protein echistatin, which specifically binds to the platelet integrin alphaIIbbeta3 receptor, to annexin V, which binds platelet membrane-associated phosphatidylserine (PS), to create the bifunctional antithrombotic molecule recombinant echistatin-annexin V fusion protein (r-EchAV).	Phosphatidylserines	209-227	annexin A5	Mus musculus	157-166
30850395-9	2019	We propose that the loss in ATP11C phospholipid flippase activity coupled with phospholipid scramblase activity results in the exposure of phosphatidylserine on the surface of RBCs, decreasing RBC survival and resulting in anemia.	Phosphatidylserines	139-157	ATPase, class VI, type 11C	Mus musculus	28-34
31069027-6	2019	We also described that a subset of ApoBDs can expose a relatively low level of phosphatidylserine on its surface based on annexin A5 staining.	Phosphatidylserines	79-97	annexin A5	Homo sapiens	122-132
31068782-10	2019	Interestingly, similar variations in PUFA and PS content correlating with alpha-syn insoluble accumulation were also detected in membrane microstructures from the human cortex of incidental Parkinson Disease (iPD) and PD, as compared to healthy controls.	Phosphatidylserines	46-48	synuclein alpha	Homo sapiens	74-83
31009511-5	2019	In this study, we first demonstrated that DENV but not Zika virus cell culture supernatant could induce P-selectin expression and phosphatidylserine (PS) exposure in human platelets, both of which were abolished when NS1 was depleted from the DENV supernatant.	Phosphatidylserines	130-148	influenza virus NS1A binding protein	Homo sapiens	217-220
30999671-4	2019	Taking into account that HspA1A interacts with lipids, including phosphatidylserine (PS), and that lipids recruit proteins to the PM, we hypothesized that the interaction of HspA1A with PS allows the chaperone to localize at the PM.	Phosphatidylserines	65-83	heat shock protein family A (Hsp70) member 1A	Homo sapiens	25-31
30999671-4	2019	Taking into account that HspA1A interacts with lipids, including phosphatidylserine (PS), and that lipids recruit proteins to the PM, we hypothesized that the interaction of HspA1A with PS allows the chaperone to localize at the PM.	Phosphatidylserines	65-83	heat shock protein family A (Hsp70) member 1A	Homo sapiens	174-180
30999671-4	2019	Taking into account that HspA1A interacts with lipids, including phosphatidylserine (PS), and that lipids recruit proteins to the PM, we hypothesized that the interaction of HspA1A with PS allows the chaperone to localize at the PM.	Phosphatidylserines	85-87	heat shock protein family A (Hsp70) member 1A	Homo sapiens	174-180
30999671-4	2019	Taking into account that HspA1A interacts with lipids, including phosphatidylserine (PS), and that lipids recruit proteins to the PM, we hypothesized that the interaction of HspA1A with PS allows the chaperone to localize at the PM.	Phosphatidylserines	186-188	heat shock protein family A (Hsp70) member 1A	Homo sapiens	25-31
30999671-4	2019	Taking into account that HspA1A interacts with lipids, including phosphatidylserine (PS), and that lipids recruit proteins to the PM, we hypothesized that the interaction of HspA1A with PS allows the chaperone to localize at the PM.	Phosphatidylserines	186-188	heat shock protein family A (Hsp70) member 1A	Homo sapiens	174-180
30999671-7	2019	Next, we selectively reduced PS targets by overexpressing the C2 domain of lactadherin (Lact-C2), a known PS-biosensor, and determined that HspA1A"s membrane localization was greatly reduced.	Phosphatidylserines	29-31	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	75-86
30999671-7	2019	Next, we selectively reduced PS targets by overexpressing the C2 domain of lactadherin (Lact-C2), a known PS-biosensor, and determined that HspA1A"s membrane localization was greatly reduced.	Phosphatidylserines	29-31	heat shock protein family A (Hsp70) member 1A	Homo sapiens	140-146
30999671-10	2019	Collectively, these results reveal that HspA1A"s PM localization and anchorage depend on its selective interaction with intracellular PS.	Phosphatidylserines	134-136	heat shock protein family A (Hsp70) member 1A	Homo sapiens	40-46
31032234-5	2019	We found that the level of PS exposure on intracellular amastigotes was modulated by CD4+ T cell and MPhi activation status in vitro and in vivo.	Phosphatidylserines	27-29	CD4 antigen	Mus musculus	85-88
30958856-5	2019	Sfh1 was found to bind various phospholipids, including PS, in vivo.	Phosphatidylserines	56-58	Sfh1p	Saccharomyces cerevisiae S288C	0-4
30958856-6	2019	Bacterially expressed and purified Sfh1 was suggested to have the ability to transport fluorescently labeled PS between liposomes by fluorescence dequenching assay in vitro.	Phosphatidylserines	109-111	Sfh1p	Saccharomyces cerevisiae S288C	35-39
30948546-2	2019	We found that the phospholipid phosphatidylserine acts as a developmentally controlled lipid rheostat that tunes Rho GTPase signaling in Arabidopsis Live superresolution single-molecule imaging revealed that the protein Rho of Plants 6 (ROP6) is stabilized by phosphatidylserine into plasma membrane nanodomains, which are required for auxin signaling.	Phosphatidylserines	31-49	RAC-like 3	Arabidopsis thaliana	220-235
30948546-2	2019	We found that the phospholipid phosphatidylserine acts as a developmentally controlled lipid rheostat that tunes Rho GTPase signaling in Arabidopsis Live superresolution single-molecule imaging revealed that the protein Rho of Plants 6 (ROP6) is stabilized by phosphatidylserine into plasma membrane nanodomains, which are required for auxin signaling.	Phosphatidylserines	31-49	RAC-like 3	Arabidopsis thaliana	237-241
30684144-3	2019	Annexin V is a 36 kDa protein which binds with high affinity to PS in the presence of Ca2+ ions.	Phosphatidylserines	64-66	annexin A5	Homo sapiens	0-9
30517655-6	2019	When PS synthesis was suppressed by the knockdown of PS synthases in cPLA2e-expressing cells, the cPLA2e level and its N-acyltransferase activity were significantly reduced.	Phosphatidylserines	5-7	phospholipase A2 group IVA	Homo sapiens	69-74
30517655-6	2019	When PS synthesis was suppressed by the knockdown of PS synthases in cPLA2e-expressing cells, the cPLA2e level and its N-acyltransferase activity were significantly reduced.	Phosphatidylserines	5-7	phospholipase A2 group IVA	Homo sapiens	98-103
30517655-8	2019	Liposome-based assays showed that several anionic glycerophospholipids, including PS, phosphatidic acid and phosphatidylinositol 4,5-bisphosphate, enhance the Ca2+-dependent binding of purified cPLA2e to liposome membrane and stimulate its N-acyltransferase activity.	Phosphatidylserines	82-84	phospholipase A2 group IVA	Homo sapiens	194-199
30444039-3	2019	The translocation and activity of SphK1 are regulated by its phosphorylation of Ser 225 and by anionic lipids such as phosphatidic acid and phosphatidylserine.	Phosphatidylserines	140-158	sphingosine kinase 1	Homo sapiens	34-39
31893253-8	2019	The K m values for adenosine triphosphate (ATP) and DG were 0.05 mM and 1.5 mol %, respectively, and the EC50 for the activator phosphatidylserine was 8.6 mol %, indicating that its affinity for ATP is moderately higher than those of DGKalpha and DGKepsilon, and its affinities for DG and phosphatidylserine are comparable to those of DGKalpha/DGKepsilon.	Phosphatidylserines	128-146	diacylglycerol kinase alpha	Homo sapiens	234-257
31893253-8	2019	The K m values for adenosine triphosphate (ATP) and DG were 0.05 mM and 1.5 mol %, respectively, and the EC50 for the activator phosphatidylserine was 8.6 mol %, indicating that its affinity for ATP is moderately higher than those of DGKalpha and DGKepsilon, and its affinities for DG and phosphatidylserine are comparable to those of DGKalpha/DGKepsilon.	Phosphatidylserines	128-146	diacylglycerol kinase alpha	Homo sapiens	335-354
30893822-8	2019	Also, we found that some MSCs and EVs were positive for annexin V, which implies the presence of phosphatidylserine on their surfaces, which can potentiate clot formation.	Phosphatidylserines	97-115	annexin A5	Homo sapiens	56-65
30889183-3	2019	We previously found that phosphatidylserine (PS), an FDA-approved food supplement, elevates IKAP levels in cells generated from FD patients.	Phosphatidylserines	25-43	elongator acetyltransferase complex subunit 1	Homo sapiens	92-96
30889183-3	2019	We previously found that phosphatidylserine (PS), an FDA-approved food supplement, elevates IKAP levels in cells generated from FD patients.	Phosphatidylserines	45-47	elongator acetyltransferase complex subunit 1	Homo sapiens	92-96
30889183-7	2019	Pridopidine has an additive effect on IKAP levels when used in combination with kinetin or TSA, but not with PS; suggesting that PS and pridopidine influence IKBKAP levels through the same mechanism.	Phosphatidylserines	129-131	elongator acetyltransferase complex subunit 1	Homo sapiens	38-42
30889183-7	2019	Pridopidine has an additive effect on IKAP levels when used in combination with kinetin or TSA, but not with PS; suggesting that PS and pridopidine influence IKBKAP levels through the same mechanism.	Phosphatidylserines	129-131	elongator acetyltransferase complex subunit 1	Homo sapiens	158-164
30858161-1	2019	Exome sequencing of two sisters with congenital cataracts, short stature, and white matter changes identified compound heterozygous variants in the PISD gene, encoding the phosphatidylserine decarboxylase enzyme that converts phosphatidylserine to phosphatidylethanolamine (PE) in the inner mitochondrial membrane (IMM).	Phosphatidylserines	172-190	phosphatidylserine decarboxylase	Homo sapiens	148-152
30858161-2	2019	Decreased conversion of phosphatidylserine to PE in patient fibroblasts is consistent with impaired phosphatidylserine decarboxylase (PISD) enzyme activity.	Phosphatidylserines	24-42	phosphatidylserine decarboxylase	Homo sapiens	100-132
30858161-2	2019	Decreased conversion of phosphatidylserine to PE in patient fibroblasts is consistent with impaired phosphatidylserine decarboxylase (PISD) enzyme activity.	Phosphatidylserines	24-42	phosphatidylserine decarboxylase	Homo sapiens	134-138
31231513-2	2019	We previously found that LMS is caused by de novo dominant missense mutations in the  PTDSS1 gene, which encodes phosphatidylserine synthase 1 (PSS1), an enzyme that catalyses the conversion of phosphatidylcholine to phosphatidylserine.	Phosphatidylserines	113-131	phosphatidylserine synthase 1a	Danio rerio	86-92
31231513-2	2019	We previously found that LMS is caused by de novo dominant missense mutations in the  PTDSS1 gene, which encodes phosphatidylserine synthase 1 (PSS1), an enzyme that catalyses the conversion of phosphatidylcholine to phosphatidylserine.	Phosphatidylserines	113-131	phosphatidylserine synthase 1a	Danio rerio	144-148
30850607-3	2019	We present structures of human PRELID1-TRIAP1 and PRELID3b-TRIAP1 complexes, which exert lipid transfer activity for phosphatidic acid and phosphatidylserine, respectively.	Phosphatidylserines	139-157	PRELI domain containing 1	Homo sapiens	31-38
30850607-3	2019	We present structures of human PRELID1-TRIAP1 and PRELID3b-TRIAP1 complexes, which exert lipid transfer activity for phosphatidic acid and phosphatidylserine, respectively.	Phosphatidylserines	139-157	TP53 regulated inhibitor of apoptosis 1	Homo sapiens	39-45
30850607-3	2019	We present structures of human PRELID1-TRIAP1 and PRELID3b-TRIAP1 complexes, which exert lipid transfer activity for phosphatidic acid and phosphatidylserine, respectively.	Phosphatidylserines	139-157	PRELI domain containing 3B	Homo sapiens	50-58
30850607-3	2019	We present structures of human PRELID1-TRIAP1 and PRELID3b-TRIAP1 complexes, which exert lipid transfer activity for phosphatidic acid and phosphatidylserine, respectively.	Phosphatidylserines	139-157	TP53 regulated inhibitor of apoptosis 1	Homo sapiens	59-65
30755463-3	2019	The ATP hydrolytic activity of the ALA2-ALIS5 complex was stimulated in a highly specific manner by phosphatidylserine.	Phosphatidylserines	100-118	aminophospholipid ATPase 2	Arabidopsis thaliana	35-39
30755463-3	2019	The ATP hydrolytic activity of the ALA2-ALIS5 complex was stimulated in a highly specific manner by phosphatidylserine.	Phosphatidylserines	100-118	ALA-interacting subunit 5	Arabidopsis thaliana	40-45
30703743-4	2019	Here, an apoptotic cell-mimicking gold nanocage (AuNC)-based nano drug carrier capable of correcting the impaired clearance of apoptotic cells in SLE was rationally designed and generated by conjugating phosphatidylserine (PS) on the surface of liposome-coated AuNCs for liver X receptor (LXR) agonist T0901317 delivery.	Phosphatidylserines	203-221	nuclear receptor subfamily 1, group H, member 3	Mus musculus	271-287
30703743-4	2019	Here, an apoptotic cell-mimicking gold nanocage (AuNC)-based nano drug carrier capable of correcting the impaired clearance of apoptotic cells in SLE was rationally designed and generated by conjugating phosphatidylserine (PS) on the surface of liposome-coated AuNCs for liver X receptor (LXR) agonist T0901317 delivery.	Phosphatidylserines	203-221	nuclear receptor subfamily 1, group H, member 3	Mus musculus	289-292
30488656-8	2019	PISD encodes phosphatidylserine (PS) decarboxylase that is localized in the inner mitochondrial membrane and catalyzes the decarboxylation of PS to phosphatidylethanolamine (PE) in mammalian cells.	Phosphatidylserines	33-35	phosphatidylserine decarboxylase	Homo sapiens	0-4
30683797-4	2019	Two substitutions that alter a highly conserved PISL motif in the fourth transmembrane domain and a highly conserved DKTGT phosphorylation motif, respectively, disrupt both functions of TAT-1, leading to a vesicular gut defect and ectopic PS exposure on the cell surface, whereas most other substitutions across the TAT-1 protein, often predicted to be deleterious by bioinformatics programs, do not affect the functions of TAT-1.	Phosphatidylserines	239-241	Phospholipid-transporting ATPase tat-1	Caenorhabditis elegans	186-191
30770580-7	2019	Administration of PS with CCl4 significantly inhibited alterations in the serum levels of AST, ALP (** P < 0.01), and ALT (*** P < 0.001) compared with control group.	Phosphatidylserines	18-20	C-C motif chemokine ligand 4	Rattus norvegicus	26-30
30770580-7	2019	Administration of PS with CCl4 significantly inhibited alterations in the serum levels of AST, ALP (** P < 0.01), and ALT (*** P < 0.001) compared with control group.	Phosphatidylserines	18-20	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	90-93
30770580-9	2019	The results of the present study showed the hepatoprotective effects of PS against CCl4 -induced hepatotoxicity in rats.	Phosphatidylserines	72-74	C-C motif chemokine ligand 4	Rattus norvegicus	83-87
30774993-4	2019	Moreover, using annexin V as a probe, we could detect surface exposure of phosphatidylserine (PS) in all three types of cell death, and this was confirmed by using specific anti-PS antibodies.	Phosphatidylserines	74-92	annexin A5	Homo sapiens	16-25
30774993-4	2019	Moreover, using annexin V as a probe, we could detect surface exposure of phosphatidylserine (PS) in all three types of cell death, and this was confirmed by using specific anti-PS antibodies.	Phosphatidylserines	94-96	annexin A5	Homo sapiens	16-25
30548258-15	2019	These effects were abrogated when MPs were removed from diabetic plasma or when diabetic MPs were pre-coated with a lipid-binding protein, annexin V, suggesting externalized PS to be key in mediating MP interactions with endothelium and leukocytes.	Phosphatidylserines	174-176	annexin A5	Rattus norvegicus	139-148
31628657-4	2019	Upon cleavage, the GSDMD-N fragments translocate on the membrane and oligomerize to form membrane-embedded pores after specifically binding to acidic lipids such as phosphatidylinositol phosphates (PIPs), phosphatidic acid (PA), phosphatidylserine (PS), and cardiolipin.	Phosphatidylserines	229-247	gasdermin D	Homo sapiens	19-24
31628657-4	2019	Upon cleavage, the GSDMD-N fragments translocate on the membrane and oligomerize to form membrane-embedded pores after specifically binding to acidic lipids such as phosphatidylinositol phosphates (PIPs), phosphatidic acid (PA), phosphatidylserine (PS), and cardiolipin.	Phosphatidylserines	249-251	gasdermin D	Homo sapiens	19-24
30551488-3	2019	Serum CRP has been shown to bind to phospholipids such as phophatidylcholine (PC), phosphatidylglycerol (PG) and phosphatidylserine (PS).	Phosphatidylserines	113-131	C-reactive protein, pentraxin-related	Mus musculus	6-9
30551488-3	2019	Serum CRP has been shown to bind to phospholipids such as phophatidylcholine (PC), phosphatidylglycerol (PG) and phosphatidylserine (PS).	Phosphatidylserines	133-135	C-reactive protein, pentraxin-related	Mus musculus	6-9
31155594-7	2019	Overall, these data suggest that conjugation with lactadherin facilitates the delivery of any protein drug to PS-exposing enveloped viruses.	Phosphatidylserines	110-112	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	50-61
31582657-8	2019	In the two-ingredient (FA and PS) group, a significant decrease in IL-1beta and an increasing trend in acetylcholine were observed.	Phosphatidylserines	30-32	interleukin 1 alpha	Mus musculus	67-75
31805226-3	2019	METHODS: Phosphatidylserine exposure at the cell surface was estimated from annexin-V-binding, reactive oxygen/nitrogen species (RONS) and nitric oxide formation from 2",7"-dichloro-dihydrofluorescein (DCF-DA) and 4-amino-5-methylamino-2",7"-difluorofluorescein diacetate (DAF-FM DA) -dependent fluorescence, respectively; Akt1, phospho-NOS3 Ser1177, and PKCzeta from Western blot analysis.	Phosphatidylserines	9-27	annexin A5	Homo sapiens	76-85
31805226-3	2019	METHODS: Phosphatidylserine exposure at the cell surface was estimated from annexin-V-binding, reactive oxygen/nitrogen species (RONS) and nitric oxide formation from 2",7"-dichloro-dihydrofluorescein (DCF-DA) and 4-amino-5-methylamino-2",7"-difluorofluorescein diacetate (DAF-FM DA) -dependent fluorescence, respectively; Akt1, phospho-NOS3 Ser1177, and PKCzeta from Western blot analysis.	Phosphatidylserines	9-27	AKT serine/threonine kinase 1	Homo sapiens	323-327
31805226-3	2019	METHODS: Phosphatidylserine exposure at the cell surface was estimated from annexin-V-binding, reactive oxygen/nitrogen species (RONS) and nitric oxide formation from 2",7"-dichloro-dihydrofluorescein (DCF-DA) and 4-amino-5-methylamino-2",7"-difluorofluorescein diacetate (DAF-FM DA) -dependent fluorescence, respectively; Akt1, phospho-NOS3 Ser1177, and PKCzeta from Western blot analysis.	Phosphatidylserines	9-27	protein kinase C zeta	Homo sapiens	355-362
30386982-10	2018	injection of PS -functionalized SLNs in improving the cognition, preserving the neuronal cells and reducing tau hyperphosphorylation in a rat model of Alzheimer"s disease.	Phosphatidylserines	13-15	microtubule associated protein tau	Homo sapiens	108-111
29454770-2	2018	BACKGROUND: During apoptosis, the cell membrane phospholipids-phosphatidylserine (PS) and phosphatidylethanolamine (PE) are exposed and can be targeted by Annexin-V and Duramycin, respectively, for in vivo imaging.	Phosphatidylserines	62-80	annexin A5	Rattus norvegicus	155-164
29529237-11	2018	In addition, circulating PS+ MPs cooperated with PS+ cells, contributing to markedly shortened coagulation time and dramatically increased FXa/thrombin generation and fibrin formation in each DKD group.	Phosphatidylserines	25-28	coagulation factor X	Homo sapiens	139-142
29529237-11	2018	In addition, circulating PS+ MPs cooperated with PS+ cells, contributing to markedly shortened coagulation time and dramatically increased FXa/thrombin generation and fibrin formation in each DKD group.	Phosphatidylserines	25-28	coagulation factor II, thrombin	Homo sapiens	143-151
29529237-13	2018	Moreover, blockade of exposed PS on MPs and cells with lactadherin inhibited PCA by ~80%.	Phosphatidylserines	30-32	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	55-66
30504845-5	2018	Consistent with the known metal ion-dependent binding of phosphatidylserine (PtdSer) to mTIM-3 and mTIM-4, the NMR spectral analysis and crystal structure of Ca++-bound hTIM-3 revealed that residues in the hTIM-3 F-G loop coordinate binding to Ca++.	Phosphatidylserines	57-75	hepatitis A virus cellular receptor 2	Mus musculus	88-94
30504845-5	2018	Consistent with the known metal ion-dependent binding of phosphatidylserine (PtdSer) to mTIM-3 and mTIM-4, the NMR spectral analysis and crystal structure of Ca++-bound hTIM-3 revealed that residues in the hTIM-3 F-G loop coordinate binding to Ca++.	Phosphatidylserines	57-75	timeless circadian regulator	Homo sapiens	169-173
30504845-5	2018	Consistent with the known metal ion-dependent binding of phosphatidylserine (PtdSer) to mTIM-3 and mTIM-4, the NMR spectral analysis and crystal structure of Ca++-bound hTIM-3 revealed that residues in the hTIM-3 F-G loop coordinate binding to Ca++.	Phosphatidylserines	57-75	timeless circadian regulator	Homo sapiens	206-210
30504845-5	2018	Consistent with the known metal ion-dependent binding of phosphatidylserine (PtdSer) to mTIM-3 and mTIM-4, the NMR spectral analysis and crystal structure of Ca++-bound hTIM-3 revealed that residues in the hTIM-3 F-G loop coordinate binding to Ca++.	Phosphatidylserines	77-83	hepatitis A virus cellular receptor 2	Mus musculus	88-94
30504845-5	2018	Consistent with the known metal ion-dependent binding of phosphatidylserine (PtdSer) to mTIM-3 and mTIM-4, the NMR spectral analysis and crystal structure of Ca++-bound hTIM-3 revealed that residues in the hTIM-3 F-G loop coordinate binding to Ca++.	Phosphatidylserines	77-83	T cell immunoglobulin and mucin domain containing 4	Mus musculus	99-105
30504845-5	2018	Consistent with the known metal ion-dependent binding of phosphatidylserine (PtdSer) to mTIM-3 and mTIM-4, the NMR spectral analysis and crystal structure of Ca++-bound hTIM-3 revealed that residues in the hTIM-3 F-G loop coordinate binding to Ca++.	Phosphatidylserines	77-83	timeless circadian regulator	Homo sapiens	169-173
30504845-5	2018	Consistent with the known metal ion-dependent binding of phosphatidylserine (PtdSer) to mTIM-3 and mTIM-4, the NMR spectral analysis and crystal structure of Ca++-bound hTIM-3 revealed that residues in the hTIM-3 F-G loop coordinate binding to Ca++.	Phosphatidylserines	77-83	timeless circadian regulator	Homo sapiens	206-210
30237174-2	2018	In yeast, the Ups1-Mdm35 and Ups2-Mdm35 complexes transfer phosphatidic acid and phosphatidylserine, respectively, between the mitochondrial outer and inner membranes.	Phosphatidylserines	81-99	Ups1p	Saccharomyces cerevisiae S288C	14-18
30237174-2	2018	In yeast, the Ups1-Mdm35 and Ups2-Mdm35 complexes transfer phosphatidic acid and phosphatidylserine, respectively, between the mitochondrial outer and inner membranes.	Phosphatidylserines	81-99	Mdm35p	Saccharomyces cerevisiae S288C	19-24
30237174-2	2018	In yeast, the Ups1-Mdm35 and Ups2-Mdm35 complexes transfer phosphatidic acid and phosphatidylserine, respectively, between the mitochondrial outer and inner membranes.	Phosphatidylserines	81-99	Ups2p	Saccharomyces cerevisiae S288C	29-33
30237174-2	2018	In yeast, the Ups1-Mdm35 and Ups2-Mdm35 complexes transfer phosphatidic acid and phosphatidylserine, respectively, between the mitochondrial outer and inner membranes.	Phosphatidylserines	81-99	Mdm35p	Saccharomyces cerevisiae S288C	34-39
30327201-2	2018	We recently presented evidence that surface exposure of phosphatidylserine (PS) is pivotal for ADAM17 to exert sheddase activity.	Phosphatidylserines	56-74	ADAM metallopeptidase domain 17	Homo sapiens	95-101
30574059-5	2018	Flow cytometry with annexin A5 binding was used to measure the exposed phosphatidylserine.	Phosphatidylserines	71-89	annexin A5	Homo sapiens	20-30
29894783-0	2018	Highly active and stable nanobiocatalyst based on in-situ cross-linking of phospholipase D for the synthesis of phosphatidylserine.	Phosphatidylserines	112-130	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	75-90
29894783-4	2018	The immobilized PLD showed high activity and stability in catalyzing the conversion of phosphatidylcholine (PC) to phosphatidylserine (PS).	Phosphatidylserines	115-133	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	16-19
29894783-4	2018	The immobilized PLD showed high activity and stability in catalyzing the conversion of phosphatidylcholine (PC) to phosphatidylserine (PS).	Phosphatidylserines	135-137	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	16-19
30190430-4	2018	Molecular dynamics simulations of the AVN membrane and experimental binding studies of CD169 to GM3-presenting AVNs reveal Na+-mediated interactions between GM3 and PS as a potential cause of the antagonistic action on binding by the two negatively charged lipids.	Phosphatidylserines	165-167	sialic acid binding Ig like lectin 1	Homo sapiens	87-92
30175537-7	2018	However, FXYD2 also stabilizes the protein by amplifying specific interactions with phosphatidylserine and cholesterol within the membrane.	Phosphatidylserines	84-102	FXYD domain containing ion transport regulator 2	Homo sapiens	9-14
30063356-5	2018	The QD-labeled annexin V (AV) was prepared to specifically target PS on the membrane of apoptotic cells, and PS was detected by fluorescent imaging, flow cytometer, and single-molecule fluorescence correlation spectroscopy (FCS).	Phosphatidylserines	66-68	annexin A5	Homo sapiens	15-24
30134156-3	2018	We report that living neurons with tau inclusions from P301S-tau mice expose abnormally high amounts of phosphatidylserine because of the production of reactive oxygen species (ROS).	Phosphatidylserines	104-122	microtubule associated protein tau	Homo sapiens	35-38
30134156-3	2018	We report that living neurons with tau inclusions from P301S-tau mice expose abnormally high amounts of phosphatidylserine because of the production of reactive oxygen species (ROS).	Phosphatidylserines	104-122	microtubule associated protein tau	Homo sapiens	61-64
29794134-3	2018	Here, we report three high-resolution structures of the extracellular ligand-binding domains (ECDs) of R47H TREM2, apo-WT, and phosphatidylserine (PS)-bound WT TREM2 at 1.8, 2.2, and 2.2 A, respectively.	Phosphatidylserines	127-145	triggering receptor expressed on myeloid cells 2	Homo sapiens	160-165
29794134-3	2018	Here, we report three high-resolution structures of the extracellular ligand-binding domains (ECDs) of R47H TREM2, apo-WT, and phosphatidylserine (PS)-bound WT TREM2 at 1.8, 2.2, and 2.2 A, respectively.	Phosphatidylserines	147-149	triggering receptor expressed on myeloid cells 2	Homo sapiens	160-165
30082731-5	2018	We show that TTR-11 binds to both the extracellular domain of integrin-alpha and phosphatidylserine (PS).	Phosphatidylserines	81-99	TransThyretin-Related family domain	Caenorhabditis elegans	13-19
30082731-6	2018	Axon injury induces the accumulation of PS around the injured axons in a manner dependent on TTR-11, the ABC transporter CED-7, and the caspase CED-3.	Phosphatidylserines	40-42	TransThyretin-Related family domain	Caenorhabditis elegans	93-99
30082731-6	2018	Axon injury induces the accumulation of PS around the injured axons in a manner dependent on TTR-11, the ABC transporter CED-7, and the caspase CED-3.	Phosphatidylserines	40-42	ABC transporter ced-7	Caenorhabditis elegans	121-126
30082731-6	2018	Axon injury induces the accumulation of PS around the injured axons in a manner dependent on TTR-11, the ABC transporter CED-7, and the caspase CED-3.	Phosphatidylserines	40-42	Cell death protein 3 subunit p17	Caenorhabditis elegans	144-149
29853537-3	2018	PS exposure and MV release were inhibited in beta3-/- platelets or by integrin antagonists.	Phosphatidylserines	0-2	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	45-50
29853537-4	2018	The impaired MV release and PS exposure in beta3-/- platelets were rescued by expression of wild-type beta3 but not a Galpha13 binding-deficient beta3 mutant (E733EE to AAA), which blocks outside-in signaling but not ligand binding.	Phosphatidylserines	28-30	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	43-48
29691802-9	2018	The dissociation constants for binding to PS/phosphatidylcholine (PC) liposomes of N-terminally acetylated (NAc) alpha-syn was lower than that of non NAc alpha-syn.	Phosphatidylserines	42-44	synuclein alpha	Homo sapiens	113-122
29691802-9	2018	The dissociation constants for binding to PS/phosphatidylcholine (PC) liposomes of N-terminally acetylated (NAc) alpha-syn was lower than that of non NAc alpha-syn.	Phosphatidylserines	42-44	synuclein alpha	Homo sapiens	154-163
29866908-12	2018	In addition, expression of AtSDC restores PS synthesis in the cho1DeltaDelta mutant, which may be due to causing PS decarboxylase to run backwards and convert PE to PS.	Phosphatidylserines	42-44	ascorbic acid mannose pathway regulator, putative (DUF295)	Arabidopsis thaliana	27-32
29866908-12	2018	In addition, expression of AtSDC restores PS synthesis in the cho1DeltaDelta mutant, which may be due to causing PS decarboxylase to run backwards and convert PE to PS.	Phosphatidylserines	113-115	ascorbic acid mannose pathway regulator, putative (DUF295)	Arabidopsis thaliana	27-32
30018401-9	2018	We also show that ATP11A, ATP11B and ATP11C, like ATP8A1 and ATP8A2, selectively flip phosphatidylserine and phosphatidylethanolamine across membranes.	Phosphatidylserines	86-104	ATPase, class VI, type 11A	Mus musculus	18-24
30018401-9	2018	We also show that ATP11A, ATP11B and ATP11C, like ATP8A1 and ATP8A2, selectively flip phosphatidylserine and phosphatidylethanolamine across membranes.	Phosphatidylserines	86-104	ATPase, class VI, type 11B	Mus musculus	26-32
30018401-9	2018	We also show that ATP11A, ATP11B and ATP11C, like ATP8A1 and ATP8A2, selectively flip phosphatidylserine and phosphatidylethanolamine across membranes.	Phosphatidylserines	86-104	ATPase, class VI, type 11C	Mus musculus	37-43
30018401-9	2018	We also show that ATP11A, ATP11B and ATP11C, like ATP8A1 and ATP8A2, selectively flip phosphatidylserine and phosphatidylethanolamine across membranes.	Phosphatidylserines	86-104	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	Mus musculus	50-56
30018401-9	2018	We also show that ATP11A, ATP11B and ATP11C, like ATP8A1 and ATP8A2, selectively flip phosphatidylserine and phosphatidylethanolamine across membranes.	Phosphatidylserines	86-104	ATPase, aminophospholipid transporter-like, class I, type 8A, member 2	Mus musculus	61-67
30057675-11	2018	Moreover, PS exposure, ECs, and MPs in RVO lead to shortened clotting time with upregulation of FXa and thrombin formation obviously.	Phosphatidylserines	10-12	coagulation factor X	Homo sapiens	96-99
30057675-11	2018	Moreover, PS exposure, ECs, and MPs in RVO lead to shortened clotting time with upregulation of FXa and thrombin formation obviously.	Phosphatidylserines	10-12	coagulation factor II, thrombin	Homo sapiens	104-112
29887339-5	2018	These excessive contact sites cause abnormal lipid trafficking that depletes phosphatidylserine from the endoplasmic reticulum (ER) and disrupts the production of neuropeptide-containing vesicles.	Phosphatidylserines	77-95	epiregulin	Homo sapiens	128-130
29543435-7	2018	Confocal images of isolated MVs bound to fluorescently labeled annexin-V via externalized phosphatidylserine revealed a polydisperse population of small spherical structures.	Phosphatidylserines	90-108	annexin A5	Homo sapiens	63-72
29874576-5	2018	PI4KA inactivation disproportionally reduced phosphatidylserine, phosphatidylethanolamine, and sphingomyelin content in mutant nerves, with similar changes observed in SCs treated with a PI4KA inhibitor.	Phosphatidylserines	45-63	phosphatidylinositol 4-kinase alpha	Mus musculus	0-5
29738703-7	2018	In contrast, Cyp3a-null males have higher liver triglyceride concentrations and lipidomic analysis indicates an increase in phosphatidylinositol, phosphatidylserine and sphingomyelin.	Phosphatidylserines	146-164	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	13-18
29621549-5	2018	The phospholipid composition was altered and, the ratio of phosphatidylserine (PS) was reduced by the deletion of OSH6.	Phosphatidylserines	59-77	oxysterol-binding protein OSH6	Saccharomyces cerevisiae S288C	114-118
29621549-6	2018	Residues involved in the transport of PS and phosphatidylinositol-4-phosphate in Osh6 of Saccharomyces cerevisiae are conserved in Y. lipolytica Osh6p and substitutions of these residues resulted in a defect in the n-alkane assimilation by Y. lipolytica.	Phosphatidylserines	38-40	oxysterol-binding protein OSH6	Saccharomyces cerevisiae S288C	81-85
29621549-6	2018	Residues involved in the transport of PS and phosphatidylinositol-4-phosphate in Osh6 of Saccharomyces cerevisiae are conserved in Y. lipolytica Osh6p and substitutions of these residues resulted in a defect in the n-alkane assimilation by Y. lipolytica.	Phosphatidylserines	38-40	oxysterol-binding protein OSH6	Saccharomyces cerevisiae S288C	145-150
29540528-2	2018	Loss of Lem3p-Dnf1/2p flippases leads to the exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE) on the cell surface in yeast, resulting in sensitivity to PS- or PE-binding peptides.	Phosphatidylserines	57-75	Lem3p	Saccharomyces cerevisiae S288C	8-13
29540528-2	2018	Loss of Lem3p-Dnf1/2p flippases leads to the exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE) on the cell surface in yeast, resulting in sensitivity to PS- or PE-binding peptides.	Phosphatidylserines	57-75	aminophospholipid-translocating P4-type ATPase DNF1	Saccharomyces cerevisiae S288C	14-21
29540528-2	2018	Loss of Lem3p-Dnf1/2p flippases leads to the exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE) on the cell surface in yeast, resulting in sensitivity to PS- or PE-binding peptides.	Phosphatidylserines	77-79	Lem3p	Saccharomyces cerevisiae S288C	8-13
29540528-2	2018	Loss of Lem3p-Dnf1/2p flippases leads to the exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE) on the cell surface in yeast, resulting in sensitivity to PS- or PE-binding peptides.	Phosphatidylserines	77-79	aminophospholipid-translocating P4-type ATPase DNF1	Saccharomyces cerevisiae S288C	14-21
29540528-2	2018	Loss of Lem3p-Dnf1/2p flippases leads to the exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE) on the cell surface in yeast, resulting in sensitivity to PS- or PE-binding peptides.	Phosphatidylserines	173-175	Lem3p	Saccharomyces cerevisiae S288C	8-13
29540528-2	2018	Loss of Lem3p-Dnf1/2p flippases leads to the exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE) on the cell surface in yeast, resulting in sensitivity to PS- or PE-binding peptides.	Phosphatidylserines	173-175	aminophospholipid-translocating P4-type ATPase DNF1	Saccharomyces cerevisiae S288C	14-21
29716893-6	2018	Other prothrombotic, complement-fixing antibodies, for example, antithymocyte globulin, typically induce TF activation dependent on C5b-7-mediated PS exposure on the outer membrane of monocytes.	Phosphatidylserines	147-149	coagulation factor III	Mus musculus	105-107
29472386-0	2018	PI(4,5)P2 controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER-PM contact sites.	Phosphatidylserines	44-46	oxysterol binding protein like 5	Homo sapiens	58-62
29447909-8	2018	Using a PS probe, we showed that cPLA2epsilon largely co-localizes with PS in plasma membrane and organelles involved in the endocytic pathway, further supporting the interaction of cPLA2epsilon with PS in living cells.	Phosphatidylserines	8-10	phospholipase A2 group IVE	Homo sapiens	33-45
29447909-8	2018	Using a PS probe, we showed that cPLA2epsilon largely co-localizes with PS in plasma membrane and organelles involved in the endocytic pathway, further supporting the interaction of cPLA2epsilon with PS in living cells.	Phosphatidylserines	72-74	phospholipase A2 group IVE	Homo sapiens	182-194
29447909-8	2018	Using a PS probe, we showed that cPLA2epsilon largely co-localizes with PS in plasma membrane and organelles involved in the endocytic pathway, further supporting the interaction of cPLA2epsilon with PS in living cells.	Phosphatidylserines	72-74	phospholipase A2 group IVE	Homo sapiens	182-194
29447909-10	2018	In conclusion, PS potently stimulated the Ca2+-dependent activity and human cPLA2epsilon isoforms also functioned as Ca-NAT.	Phosphatidylserines	15-17	phospholipase A2 group IVE	Homo sapiens	76-88
29453885-6	2018	RESULTS: Exogenous bacterial neuraminidase significantly augmented membrane PS exposure and cytosolic Ca2+ levels in a dose- and time-dependent manner.	Phosphatidylserines	76-78	neuraminidase 1	Homo sapiens	29-42
29453885-8	2018	Neuraminidase-induced PS exposure was significantly curtailed by pretreatment with the pan-sialidase inhibitor N-acetyl-2,3-dehydro-2-deoxyneuraminic acid.	Phosphatidylserines	22-24	neuraminidase 1	Homo sapiens	0-13
29899957-8	2018	Moreover, the use of platelet-permeable stapled Bim BH3 peptides confirms the part of Bim in phosphatidyl-serine (PS) exposure and reveals a role for the Bim protein in platelet activatory processes.	Phosphatidylserines	93-112	BCL2 like 11	Homo sapiens	48-51
29899957-8	2018	Moreover, the use of platelet-permeable stapled Bim BH3 peptides confirms the part of Bim in phosphatidyl-serine (PS) exposure and reveals a role for the Bim protein in platelet activatory processes.	Phosphatidylserines	93-112	BCL2 like 11	Homo sapiens	86-89
29899957-8	2018	Moreover, the use of platelet-permeable stapled Bim BH3 peptides confirms the part of Bim in phosphatidyl-serine (PS) exposure and reveals a role for the Bim protein in platelet activatory processes.	Phosphatidylserines	93-112	BCL2 like 11	Homo sapiens	86-89
29899957-8	2018	Moreover, the use of platelet-permeable stapled Bim BH3 peptides confirms the part of Bim in phosphatidyl-serine (PS) exposure and reveals a role for the Bim protein in platelet activatory processes.	Phosphatidylserines	114-116	BCL2 like 11	Homo sapiens	86-89
29899957-8	2018	Moreover, the use of platelet-permeable stapled Bim BH3 peptides confirms the part of Bim in phosphatidyl-serine (PS) exposure and reveals a role for the Bim protein in platelet activatory processes.	Phosphatidylserines	114-116	BCL2 like 11	Homo sapiens	86-89
29755460-3	2018	During apoptosis, PR3 is co-externalized with phosphatidylserine (PS) and is known to modulate the clearance of apoptotic cells through a calreticulin (CRT)-dependent mechanism.	Phosphatidylserines	46-64	proteinase 3	Rattus norvegicus	18-21
29755460-3	2018	During apoptosis, PR3 is co-externalized with phosphatidylserine (PS) and is known to modulate the clearance of apoptotic cells through a calreticulin (CRT)-dependent mechanism.	Phosphatidylserines	66-68	proteinase 3	Rattus norvegicus	18-21
29755460-3	2018	During apoptosis, PR3 is co-externalized with phosphatidylserine (PS) and is known to modulate the clearance of apoptotic cells through a calreticulin (CRT)-dependent mechanism.	Phosphatidylserines	66-68	calreticulin	Rattus norvegicus	152-155
29615818-0	2018	Effect of Phosphatidylserine and Cholesterol on Membrane-mediated Fibril Formation by the N-terminal Amyloidogenic Fragment of Apolipoprotein A-I.	Phosphatidylserines	10-28	apolipoprotein A1	Homo sapiens	127-145
29615818-1	2018	Here, we examined the effects of phosphatidylserine (PS) and cholesterol on the fibril-forming properties of the N-terminal 1-83 fragment of an amyloidogenic G26R variant of apoA-I bound to small unilamellar vesicles.	Phosphatidylserines	33-51	apolipoprotein A1	Homo sapiens	174-180
29615818-3	2018	Circular dichroism analyses demonstrated that PS facilitates a structural transition from random coil to alpha-helix in apoA-I 1-83/G26R with great stabilization of the alpha-helical structure upon lipid binding.	Phosphatidylserines	46-48	apolipoprotein A1	Homo sapiens	120-126
29615818-4	2018	Isothermal titration calorimetry measurements revealed that PS induces a marked increase in capacity for binding of apoA-I 1-83/G26R to the membrane surface, perhaps due to electrostatic interactions of positively charged amino acids in apoA-I with PS.	Phosphatidylserines	60-62	apolipoprotein A1	Homo sapiens	116-122
29615818-4	2018	Isothermal titration calorimetry measurements revealed that PS induces a marked increase in capacity for binding of apoA-I 1-83/G26R to the membrane surface, perhaps due to electrostatic interactions of positively charged amino acids in apoA-I with PS.	Phosphatidylserines	60-62	apolipoprotein A1	Homo sapiens	237-243
29615818-4	2018	Isothermal titration calorimetry measurements revealed that PS induces a marked increase in capacity for binding of apoA-I 1-83/G26R to the membrane surface, perhaps due to electrostatic interactions of positively charged amino acids in apoA-I with PS.	Phosphatidylserines	249-251	apolipoprotein A1	Homo sapiens	116-122
29615818-4	2018	Isothermal titration calorimetry measurements revealed that PS induces a marked increase in capacity for binding of apoA-I 1-83/G26R to the membrane surface, perhaps due to electrostatic interactions of positively charged amino acids in apoA-I with PS.	Phosphatidylserines	249-251	apolipoprotein A1	Homo sapiens	237-243
29615818-5	2018	Such effects of PS to enhance lipid interactions and inhibit fibril formation of apoA-I were also observed for the amyloidogenic region-containing apoA-I 8-33/G26R peptide.	Phosphatidylserines	16-18	apolipoprotein A1	Homo sapiens	81-87
29615818-5	2018	Such effects of PS to enhance lipid interactions and inhibit fibril formation of apoA-I were also observed for the amyloidogenic region-containing apoA-I 8-33/G26R peptide.	Phosphatidylserines	16-18	apolipoprotein A1	Homo sapiens	147-153
29615818-6	2018	Fluorescence measurements using environment-sensitive probes indicated that PS induces a more solvent-exposed, membrane-bound conformation in the amyloidogenic region of apoA-I without affecting membrane fluidity.	Phosphatidylserines	76-78	apolipoprotein A1	Homo sapiens	170-176
29332224-8	2018	Confocal microscopy showed that the FVa/FXa complex and fibrin fibrils colocalized with PS on ET serum-cultured ECs.	Phosphatidylserines	88-90	coagulation factor X	Homo sapiens	40-43
29277655-11	2018	Phosphatidylserine, a phospholipid whose hydrocarbon tails contain stearic and oleic acids also inhibits TMEM16A.	Phosphatidylserines	0-18	anoctamin 1	Homo sapiens	105-112
29353693-9	2018	We find that the negatively charged phosphatidylserine lipids in the inner leaflet of the membrane tend to form an annulus around P-gp.	Phosphatidylserines	36-54	ATP binding cassette subfamily B member 1	Homo sapiens	130-134
29556135-7	2018	DNA cleavage study revealed that 5 induces cell death through apoptosis and shows more effects after 24 and/or 48 h. Independent validation of apoptosis by following the externalization of phosphatidylserine using Annexin-V is also in agreement with the potential activity of 5.	Phosphatidylserines	189-207	annexin A5	Homo sapiens	214-223
29032301-6	2018	By treating PC vesicles with PLD in the presence of 1.7M serine and 0.3M ethanolamine, we obtained asymmetric vesicles that are topologically similar to intracellular vesicles containing phosphatidylserine and phosphatidylethanolamine in the cytosolic leaflet.	Phosphatidylserines	187-205	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	29-32
29158292-2	2018	We show here that multiple acid sphingomyelinase (ASM) inhibitors, including tricyclic antidepressants, mislocalized phosphatidylserine (PtdSer) and K-RasG12V from the PM, resulting in abrogation of K-RasG12V signaling and potent, selective growth inhibition of mutant K-Ras-transformed cancer cells.	Phosphatidylserines	117-135	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	50-53
29295901-6	2018	When cells enter apoptosis, phosphatidyl serine (PS), which is normally found on the inside of the cytoplasmic membrane, is found on the extracellular surface of the membrane, thus revealing Annexin V-binding sites.	Phosphatidylserines	28-47	annexin A5	Homo sapiens	191-200
29295901-6	2018	When cells enter apoptosis, phosphatidyl serine (PS), which is normally found on the inside of the cytoplasmic membrane, is found on the extracellular surface of the membrane, thus revealing Annexin V-binding sites.	Phosphatidylserines	49-51	annexin A5	Homo sapiens	191-200
29295901-7	2018	Because binding of Annexin V to PS is calcium dependent, the buffers used for this assay must contain 1 mm calcium.	Phosphatidylserines	32-34	annexin A5	Homo sapiens	19-28
28879486-2	2018	In the present study the Forster resonance energy transfer (FRET) between anthrylvinyl-labeled phosphatidylcholine as a donor and heme moiety of cyt c as an acceptor was employed to give a quantitative characterization of the protein binding to the model membranes from the mixtures of phosphatidylcholine (PC) with phosphatidylglycerol (PG), phosphatidylserine (PS) or cardiolipin (CL) in different molar ratios.	Phosphatidylserines	343-361	cytochrome c, somatic	Homo sapiens	145-150
28879486-2	2018	In the present study the Forster resonance energy transfer (FRET) between anthrylvinyl-labeled phosphatidylcholine as a donor and heme moiety of cyt c as an acceptor was employed to give a quantitative characterization of the protein binding to the model membranes from the mixtures of phosphatidylcholine (PC) with phosphatidylglycerol (PG), phosphatidylserine (PS) or cardiolipin (CL) in different molar ratios.	Phosphatidylserines	363-365	cytochrome c, somatic	Homo sapiens	145-150
30016790-2	2018	In this report, we identified phosphatidylserine-specific phospholipase PLA1A as a host factor that modulates the TBK1 activation.	Phosphatidylserines	30-48	phospholipase A1 member A	Homo sapiens	72-77
30016790-2	2018	In this report, we identified phosphatidylserine-specific phospholipase PLA1A as a host factor that modulates the TBK1 activation.	Phosphatidylserines	30-48	TANK binding kinase 1	Homo sapiens	114-118
30689326-9	2018	The anti-tuberculosis chemotherapy gives rise to activation of phospholipase A2 that shows membrane destructive effect on mononuclears of peripheral blood and results in disorganization of their membranes manifesting in cumulation of lysophospholipids at simultaneous decreasing of percentage content of phosphatidylserine and phosphatidylcholine.	Phosphatidylserines	304-322	phospholipase A2 group IB	Homo sapiens	63-79
28939556-3	2018	In the current study, we have generated phosphatidylserine-targeting agents by fusing phosphatidylserine-binding domains to a human IgG1-derived Fc fragment.	Phosphatidylserines	40-58	LOC105243590	Mus musculus	132-136
28939556-5	2018	Conjugation of Fc-Syt1 to the cytotoxic drug monomethyl auristatin E results in a protein-drug conjugate (PDC) that is internalized into target cells and, due to the Ca2+ dependence of phosphatidylserine binding, dissociates from phosphatidylserine in early endosomes.	Phosphatidylserines	185-203	synaptotagmin I	Mus musculus	18-22
28939556-5	2018	Conjugation of Fc-Syt1 to the cytotoxic drug monomethyl auristatin E results in a protein-drug conjugate (PDC) that is internalized into target cells and, due to the Ca2+ dependence of phosphatidylserine binding, dissociates from phosphatidylserine in early endosomes.	Phosphatidylserines	230-248	synaptotagmin I	Mus musculus	18-22
29577851-6	2018	METHODS: Recombinant human alpha-synuclein was expressed and isolated and incubated in the presence of phosphatidylcholine and phosphatidylserine (PC/PS) containing liposomes.	Phosphatidylserines	127-145	synuclein alpha	Homo sapiens	27-42
29257055-1	2017	Background: Although domain IV of annexin A5 (anxA5) may be less effective in binding phosphatidylserine (PS), the four domains together may guarantee the maximum binding of anxA5 to the PS membrane.	Phosphatidylserines	86-104	annexin A5	Homo sapiens	34-44
29257055-1	2017	Background: Although domain IV of annexin A5 (anxA5) may be less effective in binding phosphatidylserine (PS), the four domains together may guarantee the maximum binding of anxA5 to the PS membrane.	Phosphatidylserines	86-104	annexin A5	Homo sapiens	46-51
29257055-1	2017	Background: Although domain IV of annexin A5 (anxA5) may be less effective in binding phosphatidylserine (PS), the four domains together may guarantee the maximum binding of anxA5 to the PS membrane.	Phosphatidylserines	106-108	annexin A5	Homo sapiens	34-44
29257055-1	2017	Background: Although domain IV of annexin A5 (anxA5) may be less effective in binding phosphatidylserine (PS), the four domains together may guarantee the maximum binding of anxA5 to the PS membrane.	Phosphatidylserines	106-108	annexin A5	Homo sapiens	46-51
29257055-8	2017	Conclusions: Truncation of domain IV of anxA5 destroys its calcium-binding ability and impairs its PS-binding activity.	Phosphatidylserines	99-101	annexin A5	Homo sapiens	40-45
29257055-9	2017	Truncation of domain IV may induce conformation change of anxA5 or reduce the hydrophobic interactions between protein and membrane, which may explain the decrease of PS-binding affinity of the mutant.	Phosphatidylserines	167-169	annexin A5	Homo sapiens	58-63
29171262-2	2017	The silica-adsorbed PC obtained was successfully used for phospholipase D (PLD)-mediated transphosphatidylation in the production of phosphatidylserine (PS).	Phosphatidylserines	133-151	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	58-73
29171262-2	2017	The silica-adsorbed PC obtained was successfully used for phospholipase D (PLD)-mediated transphosphatidylation in the production of phosphatidylserine (PS).	Phosphatidylserines	133-151	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	75-78
29527284-1	2017	We recently identified a peptide-peptoid hybrid, PPS1, which specifically recognized lipid-phosphatidylserine (PS).	Phosphatidylserines	91-109	interferon regulatory factor 6	Homo sapiens	49-53
28923840-4	2017	In addition to its ligand growth arrest specific-6 (Gas6), activation of AXL requires the lipid moiety phosphatidylserine (PS).	Phosphatidylserines	103-121	AXL receptor tyrosine kinase	Homo sapiens	73-76
28923840-4	2017	In addition to its ligand growth arrest specific-6 (Gas6), activation of AXL requires the lipid moiety phosphatidylserine (PS).	Phosphatidylserines	123-125	AXL receptor tyrosine kinase	Homo sapiens	73-76
28941037-3	2017	DOC2B interacts in vitro with the PM components phosphatidylserine, phosphatidylinositol (4, 5)-bisphosphate [PI(4, 5)P2 ] and target SNAREs (t-SNAREs).	Phosphatidylserines	48-66	double C2 domain beta	Homo sapiens	0-5
29296890-13	2017	However, both mechanisms result in the enhancement of PS at the outer leaflet that is responsible for TF decryption.	Phosphatidylserines	54-56	coagulation factor III, tissue factor	Homo sapiens	102-104
28821560-2	2017	The C2A domain of Synaptotagmin-I (C2Am), which binds to the phosphatidylserine (PS) exposed by apoptotic and necrotic cells, has been developed as an imaging probe for detecting cell death.	Phosphatidylserines	61-79	synaptotagmin 1	Homo sapiens	18-33
29176978-0	2017	Requirement of Gamma-Carboxyglutamic Acid Modification and Phosphatidylserine Binding for the Activation of Tyro3, Axl, and Mertk Receptors by Growth Arrest-Specific 6.	Phosphatidylserines	59-77	TYRO3 protein tyrosine kinase	Homo sapiens	108-113
29176978-0	2017	Requirement of Gamma-Carboxyglutamic Acid Modification and Phosphatidylserine Binding for the Activation of Tyro3, Axl, and Mertk Receptors by Growth Arrest-Specific 6.	Phosphatidylserines	59-77	AXL receptor tyrosine kinase	Homo sapiens	115-118
29176978-0	2017	Requirement of Gamma-Carboxyglutamic Acid Modification and Phosphatidylserine Binding for the Activation of Tyro3, Axl, and Mertk Receptors by Growth Arrest-Specific 6.	Phosphatidylserines	59-77	growth arrest specific 6	Homo sapiens	143-167
29176978-4	2017	Using TAM/IFNgammaR1 reporter cell lines to monitor functional TAM activity, we found that Gas6 activity was exquisitely dependent on vitamin K-mediated gamma-carboxylation, whereby replacing vitamin K with anticoagulant warfarin, or by substituting glutamic acid residues involved in PS binding, completely abrogated Gas6 activity as a TAM ligand.	Phosphatidylserines	285-287	growth arrest specific 6	Homo sapiens	91-95
29176978-7	2017	Finally, we found that distinct sources of PS-positive cells/vesicles (including apoptotic cells, calcium-induced stressed cells, and exosomes) bound Gas6 and acted as cell-derived or exosome-derived ligands to activate TAMs.	Phosphatidylserines	43-45	growth arrest specific 6	Homo sapiens	150-154
29176978-8	2017	Taken together, our findings indicate that PS is indispensable for TAM activation by Gas6, and by inference, provides new perspectives on how PS, regulates TAM receptors and efferocytosis.	Phosphatidylserines	43-45	growth arrest specific 6	Homo sapiens	85-89
28114790-5	2017	Thus, the specific activities of the patient"s LPL determined with triolein emulsified with PC were significantly higher than those with PE, PS, PI or LPC as emulsifiers.	Phosphatidylserines	141-143	lipoprotein lipase	Homo sapiens	47-50
28009236-4	2017	PS exposure on the cell surface and the release of MPs provide binding sites for factor Xa and prothrombinase complexes that promote thrombin formation.	Phosphatidylserines	0-2	coagulation factor X	Homo sapiens	81-90
28009236-4	2017	PS exposure on the cell surface and the release of MPs provide binding sites for factor Xa and prothrombinase complexes that promote thrombin formation.	Phosphatidylserines	0-2	coagulation factor X	Homo sapiens	95-109
28009236-4	2017	PS exposure on the cell surface and the release of MPs provide binding sites for factor Xa and prothrombinase complexes that promote thrombin formation.	Phosphatidylserines	0-2	coagulation factor II, thrombin	Homo sapiens	98-106
29093443-3	2017	Here, we show that one of the factors regulating YAP is phosphatidylserine (PS) in recycling endosomes (REs).	Phosphatidylserines	56-74	Yes1 associated transcriptional regulator	Homo sapiens	49-52
29093443-6	2017	Knockdown of ATP8A1 (an RE PS-flippase) or evectin-2 (an RE-resident protein) and masking of PS in the cytoplasmic leaflet of membranes, all suppress nuclear localization of YAP and YAP-dependent transcription.	Phosphatidylserines	27-29	ATPase phospholipid transporting 8A1	Homo sapiens	13-19
29051586-0	2017	Phosphatidylserine-Induced Conformational Modulation of Immune Cell Exhaustion-Associated Receptor TIM3.	Phosphatidylserines	0-18	hepatitis A virus cellular receptor 2	Homo sapiens	99-103
29037260-8	2017	In addition, the cytotoxic action of LIP depended on the phosphatidylserine (PS) content of the cell membrane.	Phosphatidylserines	57-75	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	37-40
29037260-8	2017	In addition, the cytotoxic action of LIP depended on the phosphatidylserine (PS) content of the cell membrane.	Phosphatidylserines	77-79	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	37-40
28802697-5	2017	The MP1-lipid membrane interaction was studied using Langmuir phosphatidylcholine and phosphatidylserine (PS) monolayers as model membrane systems.	Phosphatidylserines	86-104	pitrilysin metallopeptidase 1	Homo sapiens	4-7
28802697-5	2017	The MP1-lipid membrane interaction was studied using Langmuir phosphatidylcholine and phosphatidylserine (PS) monolayers as model membrane systems.	Phosphatidylserines	106-108	pitrilysin metallopeptidase 1	Homo sapiens	4-7
28802697-6	2017	PS was chosen since this negatively charged lipid was found predominantly on the outer leaflet of tumor cells, and it enhances MP1 activity for PS-containing membranes to a greater extent than for other negatively charged lipids.	Phosphatidylserines	0-2	pitrilysin metallopeptidase 1	Homo sapiens	127-130
28802697-6	2017	PS was chosen since this negatively charged lipid was found predominantly on the outer leaflet of tumor cells, and it enhances MP1 activity for PS-containing membranes to a greater extent than for other negatively charged lipids.	Phosphatidylserines	144-146	pitrilysin metallopeptidase 1	Homo sapiens	127-130
28802697-7	2017	MP1 incorporated into anionic PS monolayers, which show a liquid-expanded (LE) phase or LE-liquid-condensed (LC) phase coexistence, up to lipid-packing densities higher than those of cell membranes.	Phosphatidylserines	30-32	pitrilysin metallopeptidase 1	Homo sapiens	0-3
28884934-6	2017	In a model system of mammary COMMA-1D cells, exogenously and endogenously expressed MFG-E8 was deposited in the extracellular matrix (ECM) with membranous particles dependently on the PS-binding motifs in the discoidin domains that were essential for association ability to extracellular vesicles (EVs).	Phosphatidylserines	184-186	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	84-90
28903085-9	2017	We find that the negatively charged phosphatidylserine lipids in the inner leaflet of the membrane tend to form an annulus around P-gp.	Phosphatidylserines	36-54	ATP binding cassette subfamily B member 1	Homo sapiens	130-134
28782177-8	2017	Objectives To develop the first membrane-bound model of the FX-GLA domain to PS at atomic level, and to identify PS-specific binding sites of the FX-GLA domain.	Phosphatidylserines	77-79	galactosidase alpha	Homo sapiens	63-66
28782177-9	2017	Methods Molecular dynamics (MD) simulations were performed to develop an atomic-level model for the FX-GLA domain bound to PS bilayers.	Phosphatidylserines	123-125	galactosidase alpha	Homo sapiens	103-106
28551176-0	2017	A unique mid-sequence linker used to multimerize the lipid-phosphatidylserine (PS) binding peptide-peptoid hybrid PPS1.	Phosphatidylserines	59-77	interferon regulatory factor 6	Homo sapiens	114-118
28551176-4	2017	We recently reported a PS binding peptide-peptoid hybrid (PPS1) that has distinct positively charged and hydrophobic residue-containing regions.	Phosphatidylserines	23-25	interferon regulatory factor 6	Homo sapiens	58-62
28872598-7	2017	Pkc1 is also regulated by Pkh1- and TORC2-dependent phosphorylation, but, in addition, by interaction with Rho1-GTP and lipids phosphatidylserine (PtdSer) and diacylglycerol (DAG).	Phosphatidylserines	127-145	protein kinase C	Saccharomyces cerevisiae S288C	0-4
28872598-7	2017	Pkc1 is also regulated by Pkh1- and TORC2-dependent phosphorylation, but, in addition, by interaction with Rho1-GTP and lipids phosphatidylserine (PtdSer) and diacylglycerol (DAG).	Phosphatidylserines	147-153	protein kinase C	Saccharomyces cerevisiae S288C	0-4
28874751-3	2017	ATP8A2 is a flippase with selectivity toward phosphatidylserine (PS), possessing a net negatively charged head group, whereas ATP8B1 exhibits selectivity toward the electrically neutral phosphatidylcholine (PC).	Phosphatidylserines	45-63	ATPase phospholipid transporting 8A2	Homo sapiens	0-6
28874751-3	2017	ATP8A2 is a flippase with selectivity toward phosphatidylserine (PS), possessing a net negatively charged head group, whereas ATP8B1 exhibits selectivity toward the electrically neutral phosphatidylcholine (PC).	Phosphatidylserines	65-67	ATPase phospholipid transporting 8A2	Homo sapiens	0-6
28717005-6	2017	Oxidized vesicles containing both phosphatidylserine and polyunsaturated fatty acids were required to promote inactivation of the ZPI-PZ complex or free ZPI, indicating that binding of the PZ-complexed or free ZPI to peroxide-modified phospholipid vesicles mediates the inactivation.	Phosphatidylserines	34-52	serpin family A member 10	Homo sapiens	130-133
28717005-6	2017	Oxidized vesicles containing both phosphatidylserine and polyunsaturated fatty acids were required to promote inactivation of the ZPI-PZ complex or free ZPI, indicating that binding of the PZ-complexed or free ZPI to peroxide-modified phospholipid vesicles mediates the inactivation.	Phosphatidylserines	34-52	serpin family A member 10	Homo sapiens	153-156
28717005-6	2017	Oxidized vesicles containing both phosphatidylserine and polyunsaturated fatty acids were required to promote inactivation of the ZPI-PZ complex or free ZPI, indicating that binding of the PZ-complexed or free ZPI to peroxide-modified phospholipid vesicles mediates the inactivation.	Phosphatidylserines	34-52	serpin family A member 10	Homo sapiens	153-156
28667788-14	2017	In vitro experiments revealed that beta2 GPI preferentially binds to PS-positive MPs.	Phosphatidylserines	69-71	apolipoprotein H	Homo sapiens	35-44
28839191-7	2017	Mechanistically, Tmem30a-mutant mouse embryonic fibroblasts (MEFs) exhibited diminished PS flippase activity and increased exposure of PS on the cell surface.	Phosphatidylserines	88-90	transmembrane protein 30A	Mus musculus	17-24
28505535-6	2017	Mechanism studies demonstrated that 24 h-treatment with compound 2b (5 muM) induced phosphatidylserine residues exposition and G2/M arrest on HT-29 cells.	Phosphatidylserines	84-102	latexin	Homo sapiens	71-74
28606933-1	2017	Phosphatidylserine decarboxylase 1 (Psd1p), an ancient enzyme that converts phosphatidylserine to phosphatidylethanolamine in the inner mitochondrial membrane, must undergo an autocatalytic self-processing event to gain activity.	Phosphatidylserines	76-94	pleckstrin and Sec7 domain containing	Homo sapiens	36-41
28788072-4	2017	Here we have characterized the isolated recombinant middle fragment of CagA (CagA-M) that contains the positively-charged PS-binding region (aa 613-636) and a putative beta1 integrin binding site, but lacks the EPIYA region, secretion signal peptide and the CagA multimerization motif.	Phosphatidylserines	122-124	S100 calcium binding protein A8	Homo sapiens	71-75
28788072-4	2017	Here we have characterized the isolated recombinant middle fragment of CagA (CagA-M) that contains the positively-charged PS-binding region (aa 613-636) and a putative beta1 integrin binding site, but lacks the EPIYA region, secretion signal peptide and the CagA multimerization motif.	Phosphatidylserines	122-124	S100 calcium binding protein A8	Homo sapiens	77-81
28788072-4	2017	Here we have characterized the isolated recombinant middle fragment of CagA (CagA-M) that contains the positively-charged PS-binding region (aa 613-636) and a putative beta1 integrin binding site, but lacks the EPIYA region, secretion signal peptide and the CagA multimerization motif.	Phosphatidylserines	122-124	S100 calcium binding protein A8	Homo sapiens	77-81
28704658-5	2017	Externalized PS strongly promotes Env-mediated membrane fusion and HIV-1 infection.	Phosphatidylserines	13-15	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	34-37
28652336-2	2017	nSMase2 is activated by diverse stimuli, including the anionic phospholipid phosphatidylserine.	Phosphatidylserines	76-94	sphingomyelin phosphodiesterase 3	Homo sapiens	0-7
28652336-10	2017	Mutation of this Asp residue in nSMase2 disrupts catalysis, allosteric activation, stimulation by phosphatidylserine, and pharmacological inhibition by the lipid-competitive inhibitor GW4869.	Phosphatidylserines	98-116	sphingomyelin phosphodiesterase 3	Homo sapiens	32-39
28495859-9	2017	Thus, the results suggest that the A-syn"s interaction with v-SNARE through its C-terminal tail and its concurrent interaction with PS in trans through its amphipathic N-terminal domain facilitate SNARE complex formation, whereby A-syn aids SNARE-dependent vesicle docking.	Phosphatidylserines	132-134	synuclein alpha	Homo sapiens	35-40
28495859-9	2017	Thus, the results suggest that the A-syn"s interaction with v-SNARE through its C-terminal tail and its concurrent interaction with PS in trans through its amphipathic N-terminal domain facilitate SNARE complex formation, whereby A-syn aids SNARE-dependent vesicle docking.	Phosphatidylserines	132-134	vesicle transport through interaction with t-SNAREs 1B	Homo sapiens	60-67
28495859-9	2017	Thus, the results suggest that the A-syn"s interaction with v-SNARE through its C-terminal tail and its concurrent interaction with PS in trans through its amphipathic N-terminal domain facilitate SNARE complex formation, whereby A-syn aids SNARE-dependent vesicle docking.	Phosphatidylserines	132-134	small NF90 (ILF3) associated RNA E	Homo sapiens	62-67
28495859-9	2017	Thus, the results suggest that the A-syn"s interaction with v-SNARE through its C-terminal tail and its concurrent interaction with PS in trans through its amphipathic N-terminal domain facilitate SNARE complex formation, whereby A-syn aids SNARE-dependent vesicle docking.	Phosphatidylserines	132-134	synuclein alpha	Homo sapiens	230-235
28495859-9	2017	Thus, the results suggest that the A-syn"s interaction with v-SNARE through its C-terminal tail and its concurrent interaction with PS in trans through its amphipathic N-terminal domain facilitate SNARE complex formation, whereby A-syn aids SNARE-dependent vesicle docking.	Phosphatidylserines	132-134	small NF90 (ILF3) associated RNA E	Homo sapiens	197-202
28274844-3	2017	In agreement with this requirement, phosphatidylserine lipids are translocated to the outer leaflet of cells, and are available for MP1 binding, depending on the presence of liquid-ordered domains.	Phosphatidylserines	36-54	pitrilysin metallopeptidase 1	Homo sapiens	132-135
28274844-4	2017	Here, we investigated the effect of PS on MP1 activity when this lipid is reconstituted in membranes of giant or large liposomes with different lipid-phase states.	Phosphatidylserines	36-38	pitrilysin metallopeptidase 1	Homo sapiens	42-45
28274844-8	2017	Based on our findings, we propose that the physicochemical properties of cancer cell membranes, which possess a much higher concentration of PS than normal cells, renders them susceptible to MP1 binding and lytic pore formation.	Phosphatidylserines	141-143	pitrilysin metallopeptidase 1	Homo sapiens	191-194
28184013-1	2017	Tyro3, Axl, and Mertk (collectively TAM receptors) are three homologous receptor tyrosine kinases that bind vitamin K-dependent endogenous ligands, Protein S (ProS), and growth arrest-specific factor 6 (Gas6), and act as bridging molecules to promote phosphatidylserine (PS)-mediated clearance of apoptotic cells (efferocytosis).	Phosphatidylserines	251-269	TYRO3 protein tyrosine kinase	Homo sapiens	0-5
28184013-1	2017	Tyro3, Axl, and Mertk (collectively TAM receptors) are three homologous receptor tyrosine kinases that bind vitamin K-dependent endogenous ligands, Protein S (ProS), and growth arrest-specific factor 6 (Gas6), and act as bridging molecules to promote phosphatidylserine (PS)-mediated clearance of apoptotic cells (efferocytosis).	Phosphatidylserines	251-269	AXL receptor tyrosine kinase	Homo sapiens	7-10
28184013-1	2017	Tyro3, Axl, and Mertk (collectively TAM receptors) are three homologous receptor tyrosine kinases that bind vitamin K-dependent endogenous ligands, Protein S (ProS), and growth arrest-specific factor 6 (Gas6), and act as bridging molecules to promote phosphatidylserine (PS)-mediated clearance of apoptotic cells (efferocytosis).	Phosphatidylserines	251-269	MER proto-oncogene, tyrosine kinase	Homo sapiens	16-21
28184013-1	2017	Tyro3, Axl, and Mertk (collectively TAM receptors) are three homologous receptor tyrosine kinases that bind vitamin K-dependent endogenous ligands, Protein S (ProS), and growth arrest-specific factor 6 (Gas6), and act as bridging molecules to promote phosphatidylserine (PS)-mediated clearance of apoptotic cells (efferocytosis).	Phosphatidylserines	251-269	growth arrest specific 6	Homo sapiens	170-201
28184013-1	2017	Tyro3, Axl, and Mertk (collectively TAM receptors) are three homologous receptor tyrosine kinases that bind vitamin K-dependent endogenous ligands, Protein S (ProS), and growth arrest-specific factor 6 (Gas6), and act as bridging molecules to promote phosphatidylserine (PS)-mediated clearance of apoptotic cells (efferocytosis).	Phosphatidylserines	251-269	growth arrest specific 6	Homo sapiens	203-207
28184013-1	2017	Tyro3, Axl, and Mertk (collectively TAM receptors) are three homologous receptor tyrosine kinases that bind vitamin K-dependent endogenous ligands, Protein S (ProS), and growth arrest-specific factor 6 (Gas6), and act as bridging molecules to promote phosphatidylserine (PS)-mediated clearance of apoptotic cells (efferocytosis).	Phosphatidylserines	271-273	TYRO3 protein tyrosine kinase	Homo sapiens	0-5
28184013-1	2017	Tyro3, Axl, and Mertk (collectively TAM receptors) are three homologous receptor tyrosine kinases that bind vitamin K-dependent endogenous ligands, Protein S (ProS), and growth arrest-specific factor 6 (Gas6), and act as bridging molecules to promote phosphatidylserine (PS)-mediated clearance of apoptotic cells (efferocytosis).	Phosphatidylserines	271-273	AXL receptor tyrosine kinase	Homo sapiens	7-10
28184013-1	2017	Tyro3, Axl, and Mertk (collectively TAM receptors) are three homologous receptor tyrosine kinases that bind vitamin K-dependent endogenous ligands, Protein S (ProS), and growth arrest-specific factor 6 (Gas6), and act as bridging molecules to promote phosphatidylserine (PS)-mediated clearance of apoptotic cells (efferocytosis).	Phosphatidylserines	271-273	MER proto-oncogene, tyrosine kinase	Homo sapiens	16-21
28184013-1	2017	Tyro3, Axl, and Mertk (collectively TAM receptors) are three homologous receptor tyrosine kinases that bind vitamin K-dependent endogenous ligands, Protein S (ProS), and growth arrest-specific factor 6 (Gas6), and act as bridging molecules to promote phosphatidylserine (PS)-mediated clearance of apoptotic cells (efferocytosis).	Phosphatidylserines	271-273	growth arrest specific 6	Homo sapiens	170-201
28184013-1	2017	Tyro3, Axl, and Mertk (collectively TAM receptors) are three homologous receptor tyrosine kinases that bind vitamin K-dependent endogenous ligands, Protein S (ProS), and growth arrest-specific factor 6 (Gas6), and act as bridging molecules to promote phosphatidylserine (PS)-mediated clearance of apoptotic cells (efferocytosis).	Phosphatidylserines	271-273	growth arrest specific 6	Homo sapiens	203-207
28579961-4	2017	Beyond that, annexin V can bind to any PS-containing phospholipid bilayer of almost all tiny forms of membranous vesicles like blood platelets, exosomes, or even nanostructured liposomes.	Phosphatidylserines	39-41	annexin A5	Homo sapiens	13-22
28322795-1	2017	We recently identified a peptide-peptoid hybrid, PPS1, which recognizes lipids that have an overall negative charge, such as phosphatidylserine (PS), phosphatidylglycerol (PG), phosphatidic acid (PA), and phosphatidylinositol (PI), but that does not bind to neutral lipids, such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), and sphingomyelin (SM).	Phosphatidylserines	125-143	interferon regulatory factor 6	Homo sapiens	49-53
28322795-4	2017	First, the fluorescence polarization (FP) binding studies of fluoresceinated-PPS1 (PPS1-FITC) to PS-, PG-, and PA-containing PC-liposomes showed that the binding of PPS1 to PC-liposomes increased as concentrations of these lipids increased.	Phosphatidylserines	97-100	interferon regulatory factor 6	Homo sapiens	77-81
28322795-4	2017	First, the fluorescence polarization (FP) binding studies of fluoresceinated-PPS1 (PPS1-FITC) to PS-, PG-, and PA-containing PC-liposomes showed that the binding of PPS1 to PC-liposomes increased as concentrations of these lipids increased.	Phosphatidylserines	97-100	interferon regulatory factor 6	Homo sapiens	83-87
28322795-4	2017	First, the fluorescence polarization (FP) binding studies of fluoresceinated-PPS1 (PPS1-FITC) to PS-, PG-, and PA-containing PC-liposomes showed that the binding of PPS1 to PC-liposomes increased as concentrations of these lipids increased.	Phosphatidylserines	97-100	interferon regulatory factor 6	Homo sapiens	83-87
28881632-4	2017	The rate of the tracer bound to erythrocytes with exposed phosphatidylserine was 89.36+-0.61% and this binding could be blocked by unlabeled Cys-Annexin V.	Phosphatidylserines	58-76	annexin A5	Rattus norvegicus	145-154
28286004-3	2017	Here we present all-atom molecular dynamics simulations (totaling 5.8 mus) to investigate the K-Ras4A protein at membranes that contain anionic lipids (phosphatidyl serine or phosphatidylinositol bisphosphate).	Phosphatidylserines	152-171	KRAS proto-oncogene, GTPase	Homo sapiens	94-101
28301379-3	2017	Rosiglitazone (RO), bortezomib (BO), phosphatidylserine (PH), ethanol (E), and radiotherapy (RA) (ROBOPHERA) stimulate the expression and increase the activity of PTEN.	Phosphatidylserines	37-55	phosphatase and tensin homolog	Homo sapiens	163-167
28150893-0	2017	EGF domain of coagulation factor IX is conducive to exposure of phosphatidylserine.	Phosphatidylserines	64-82	coagulation factor IX	Homo sapiens	14-35
28150893-11	2017	Staining with annexin V and XII revealed that PS was exposed at the tips of filopodia, translocated on filopodial shafts, and co-localized with CTxB at the rafts.	Phosphatidylserines	46-48	annexin A5	Homo sapiens	14-23
28154205-2	2017	Pkc1 is structurally similar to its counterparts in higher eukaryotes, but its requirement of phosphatidylserine (PS) and diacylglycerol (DAG) for catalytic activity has been unclear.	Phosphatidylserines	94-112	protein kinase C	Saccharomyces cerevisiae S288C	0-4
28154205-2	2017	Pkc1 is structurally similar to its counterparts in higher eukaryotes, but its requirement of phosphatidylserine (PS) and diacylglycerol (DAG) for catalytic activity has been unclear.	Phosphatidylserines	114-116	protein kinase C	Saccharomyces cerevisiae S288C	0-4
28154205-6	2017	Compared with DAG, PS had a greater effect on Pkc1 activity, and its dose-dependent interaction with the protein kinase was shown by the liposome binding assay.	Phosphatidylserines	19-21	protein kinase C	Saccharomyces cerevisiae S288C	46-50
28553323-0	2017	Phosphatidylserine improves axonal transport by inhibition of HDAC and has potential in treatment of neurodegenerative diseases.	Phosphatidylserines	0-18	histone deacetylase 9	Homo sapiens	62-66
28087734-8	2017	Mass spectrometry analysis revealed an increase of phosphatidylethanolamines and phosphatidylserines in mitochondria isolated from SBMA muscles, as well as a 50% depletion of cardiolipin associated with decreased expression of the cardiolipin synthase gene.	Phosphatidylserines	81-100	androgen receptor	Homo sapiens	131-135
28193492-10	2017	ACSL4 knockdown changed the patterns of fatty acids in phosphatidylserines and phosphatidylethanolamines.	Phosphatidylserines	55-74	acyl-CoA synthetase long-chain family member 4	Rattus norvegicus	0-5
28158422-1	2017	Phosphatidylserine (PS) synthase (Cho1p) and the PS decarboxylase enzymes (Psd1p and Psd2p), which synthesize PS and phosphatidylethanolamine (PE), respectively, are crucial for Candida albicans virulence.	Phosphatidylserines	20-22	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	34-39
28451058-4	2017	GSK3B-MCL1 pathway affects ATP production locally in degenerating axons and the exposure of phosphatidylserine (PS), an "eat-me" signal for phagocytes, on degenerating axons, resulting in the failed engulfment of axonal debris in vivo.	Phosphatidylserines	92-110	glycogen synthase kinase 3 beta	Homo sapiens	0-5
28451058-4	2017	GSK3B-MCL1 pathway affects ATP production locally in degenerating axons and the exposure of phosphatidylserine (PS), an "eat-me" signal for phagocytes, on degenerating axons, resulting in the failed engulfment of axonal debris in vivo.	Phosphatidylserines	92-110	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	6-10
28451058-4	2017	GSK3B-MCL1 pathway affects ATP production locally in degenerating axons and the exposure of phosphatidylserine (PS), an "eat-me" signal for phagocytes, on degenerating axons, resulting in the failed engulfment of axonal debris in vivo.	Phosphatidylserines	112-114	glycogen synthase kinase 3 beta	Homo sapiens	0-5
28451058-4	2017	GSK3B-MCL1 pathway affects ATP production locally in degenerating axons and the exposure of phosphatidylserine (PS), an "eat-me" signal for phagocytes, on degenerating axons, resulting in the failed engulfment of axonal debris in vivo.	Phosphatidylserines	112-114	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	6-10
28065784-6	2017	We herein provide evidence to show the physical interaction between the C1 domain of Pkc1 and phosphatidylserine (PS), but not DAG.	Phosphatidylserines	94-112	protein kinase C	Saccharomyces cerevisiae S288C	85-89
28065784-6	2017	We herein provide evidence to show the physical interaction between the C1 domain of Pkc1 and phosphatidylserine (PS), but not DAG.	Phosphatidylserines	114-116	protein kinase C	Saccharomyces cerevisiae S288C	85-89
28065784-9	2017	Our results suggest that PS is necessary for Pkc1 signaling due to its role in regulating the localization of Pkc1 as well as the physical interaction between Rho1 and Pkc1.	Phosphatidylserines	25-27	protein kinase C	Saccharomyces cerevisiae S288C	45-49
28065784-9	2017	Our results suggest that PS is necessary for Pkc1 signaling due to its role in regulating the localization of Pkc1 as well as the physical interaction between Rho1 and Pkc1.	Phosphatidylserines	25-27	protein kinase C	Saccharomyces cerevisiae S288C	110-114
28065784-9	2017	Our results suggest that PS is necessary for Pkc1 signaling due to its role in regulating the localization of Pkc1 as well as the physical interaction between Rho1 and Pkc1.	Phosphatidylserines	25-27	Rho family GTPase RHO1	Saccharomyces cerevisiae S288C	159-163
28065784-9	2017	Our results suggest that PS is necessary for Pkc1 signaling due to its role in regulating the localization of Pkc1 as well as the physical interaction between Rho1 and Pkc1.	Phosphatidylserines	25-27	protein kinase C	Saccharomyces cerevisiae S288C	110-114
28001010-5	2017	RESULTS: LBP gene expression was negatively associated with phosphatidylcholine, phosphatidylserine, and sphingomyelin relative abundance in vivo.	Phosphatidylserines	81-99	lipopolysaccharide binding protein	Homo sapiens	9-12
27928104-8	2017	It was found that PS was gradually incorporated into HDPC cytoplasm for several days.	Phosphatidylserines	18-20	decapping mRNA 2	Homo sapiens	53-57
28127382-4	2017	RESULTS: Supplementation with MFGM mixtures enriched in polar lipids (BSC and CMLc, but not CML) increased the plasma phosphatidylcholine (PC) concentration, with no effect on plasma phosphatidylinositol (PI), phosphatidylethanolamine (PE), phosphatidylserine (PS) or sphingomyelin (SM).	Phosphatidylserines	241-259	milk fat globule EGF and factor V/VIII domain containing	Rattus norvegicus	30-34
28127382-4	2017	RESULTS: Supplementation with MFGM mixtures enriched in polar lipids (BSC and CMLc, but not CML) increased the plasma phosphatidylcholine (PC) concentration, with no effect on plasma phosphatidylinositol (PI), phosphatidylethanolamine (PE), phosphatidylserine (PS) or sphingomyelin (SM).	Phosphatidylserines	261-263	milk fat globule EGF and factor V/VIII domain containing	Rattus norvegicus	30-34
28066958-9	2017	Instead, it is suggested that the level of membrane surface-exposed phosphatidylserine is of crucial importance for the activity of peptide NK-2 and enhanced variants thereof in terms of their cancer cell selectivity, the overall efficacy, as well as the underlying mode of action and kinetics.	Phosphatidylserines	68-86	NK2 homeobox 1	Homo sapiens	140-144
27997532-6	2016	Phosphatidylserine treatment decreased HDAC6 levels and thus increased acetylation of alpha-tubulin.	Phosphatidylserines	0-18	histone deacetylase 6	Mus musculus	39-44
27738341-7	2016	Cells expressing increased PS concentrations show comparatively higher procoagulatory efficacy on the basis of equimolar tTF-NGR present in the Factor X assay.	Phosphatidylserines	27-29	reticulon 4 receptor	Homo sapiens	125-128
27716475-4	2016	We used liposomes containing the "eat-me" signal phosphatidylserine (PS) (PS-containing liposomes; PSL), which have macrophage targeting ability and anti-inflammatory functions, as a biomaterial carrier for the delivery of IL-10 to macrophages.	Phosphatidylserines	49-67	interleukin 10	Mus musculus	223-228
27716475-4	2016	We used liposomes containing the "eat-me" signal phosphatidylserine (PS) (PS-containing liposomes; PSL), which have macrophage targeting ability and anti-inflammatory functions, as a biomaterial carrier for the delivery of IL-10 to macrophages.	Phosphatidylserines	74-76	interleukin 10	Mus musculus	223-228
27733620-4	2016	In this study, we found that ATP9A is localized to phosphatidylserine (PS)-positive early and recycling endosomes, but not late endosomes, in HeLa cells.	Phosphatidylserines	51-69	ATPase phospholipid transporting 9A (putative)	Homo sapiens	29-34
27733620-4	2016	In this study, we found that ATP9A is localized to phosphatidylserine (PS)-positive early and recycling endosomes, but not late endosomes, in HeLa cells.	Phosphatidylserines	71-73	ATPase phospholipid transporting 9A (putative)	Homo sapiens	29-34
27537737-10	2016	Moreover, blockade of exposed PS on MPs and cells with lactadherin inhibited PCA by approximately 70%.	Phosphatidylserines	30-32	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	55-66
27827357-6	2016	RESULTS We observed that at the time of 6 h and 24 h, thrombin-stimulated vehicle platelets induced significant depo-larization of DeltaPsim, higher PS exposure, and increased ROS production compared with the vehicle group (P<0.01).	Phosphatidylserines	149-151	coagulation factor II, thrombin	Homo sapiens	54-62
27827357-8	2016	CONCLUSIONS The platelet integrin alphaIIbbeta3 inhibitor, tirofiban, inhibits the depolarization of DYm, PS exposure on platelet surface, and ROS production when stimulated with thrombin.	Phosphatidylserines	106-108	coagulation factor II, thrombin	Homo sapiens	179-187
27723344-3	2016	Using microsecond-long molecular dynamics simulations, we analyzed interaction of CYP3A4 with bilayers composed of lipids differing in their polar head groups, i.e., phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylglycerol.	Phosphatidylserines	213-231	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	82-88
27624766-8	2016	The lipids used for alpha-Syn capture consist of phosphatidyl inositol (PI), phosphatidyl serine (PS), and phosphatidyl ethanolamine (PE).	Phosphatidylserines	98-100	synuclein alpha	Homo sapiens	20-29
27803250-4	2016	Annexin V, a 36-kDa calcium-binding protein, binds to PS; therefore, fluorescently labeled Annexin V can be used to detect PS that is exposed on the outside of apoptotic cells.	Phosphatidylserines	54-56	annexin A5	Homo sapiens	0-9
27803250-4	2016	Annexin V, a 36-kDa calcium-binding protein, binds to PS; therefore, fluorescently labeled Annexin V can be used to detect PS that is exposed on the outside of apoptotic cells.	Phosphatidylserines	54-56	annexin A5	Homo sapiens	91-100
27791979-1	2016	The Ca2+-sensor synaptotagmin-1 that triggers neuronal exocytosis binds to negatively charged membrane lipids (mainly phosphatidylserine (PtdSer) and phosphoinositides (PtdIns)) but the molecular details of this process are not fully understood.	Phosphatidylserines	118-136	synaptotagmin 1	Rattus norvegicus	16-31
27666314-0	2016	Aqueous-Solid System for Highly Efficient and Environmentally Friendly Transphosphatidylation Catalyzed by Phospholipase D To Produce Phosphatidylserine.	Phosphatidylserines	134-152	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	107-122
27431011-2	2016	Previous studies from our laboratory have shown that pretreatment of FVIII in the presence of phosphatidylserine (PS) resulted in hyporesponsiveness to subsequent administration of FVIII alone, due to the ability of PS to convert an immunogen to a tolerogen.	Phosphatidylserines	94-112	coagulation factor VIII	Mus musculus	69-74
27431011-2	2016	Previous studies from our laboratory have shown that pretreatment of FVIII in the presence of phosphatidylserine (PS) resulted in hyporesponsiveness to subsequent administration of FVIII alone, due to the ability of PS to convert an immunogen to a tolerogen.	Phosphatidylserines	94-112	coagulation factor VIII	Mus musculus	181-186
27431011-4	2016	PS particles were prepared differing in size, protein-lipid topology, lamellarity, and % association to FVIII keeping the composition of the particle same.	Phosphatidylserines	0-2	coagulation factor VIII	Mus musculus	104-109
27622308-4	2016	Phosphatidylserine (PS) exposure was confirmed by annexin A5 (A5) binding using fluorescence microscopy and flow cytometry.	Phosphatidylserines	0-18	annexin A5	Homo sapiens	50-60
27622308-4	2016	Phosphatidylserine (PS) exposure was confirmed by annexin A5 (A5) binding using fluorescence microscopy and flow cytometry.	Phosphatidylserines	20-22	annexin A5	Homo sapiens	50-60
27670677-5	2016	Decreased PS exposure in 14-3-3zeta-deficient platelets is associated with more sustained levels of metabolic ATP and increased mitochondrial respiratory reserve, independent of alterations in cytosolic calcium flux.	Phosphatidylserines	10-12	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	Mus musculus	25-35
27670677-6	2016	Reduced platelet PS exposure in 14-3-3zeta-deficient mice does not increase bleeding risk, but results in decreased thrombin generation and protection from pulmonary embolism, leading to prolonged survival.	Phosphatidylserines	17-19	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	Mus musculus	32-42
27670677-7	2016	Our studies define an important role for 14-3-3zeta in regulating platelet bioenergetics, leading to decreased platelet PS exposure and procoagulant function.	Phosphatidylserines	120-122	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	Mus musculus	41-51
27641898-6	2016	Phosphatidylserine (PS), an "eat-me" signal for macrophages, is rapidly sorted from adjacent sarcolemma to the repair patch in a Dysferlin (Dysf) dependent process in zebrafish and human cells.	Phosphatidylserines	0-18	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	Danio rerio	129-138
27641898-6	2016	Phosphatidylserine (PS), an "eat-me" signal for macrophages, is rapidly sorted from adjacent sarcolemma to the repair patch in a Dysferlin (Dysf) dependent process in zebrafish and human cells.	Phosphatidylserines	0-18	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	Danio rerio	129-133
27641898-6	2016	Phosphatidylserine (PS), an "eat-me" signal for macrophages, is rapidly sorted from adjacent sarcolemma to the repair patch in a Dysferlin (Dysf) dependent process in zebrafish and human cells.	Phosphatidylserines	20-22	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	Danio rerio	129-138
27641898-6	2016	Phosphatidylserine (PS), an "eat-me" signal for macrophages, is rapidly sorted from adjacent sarcolemma to the repair patch in a Dysferlin (Dysf) dependent process in zebrafish and human cells.	Phosphatidylserines	20-22	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	Danio rerio	129-133
27641898-7	2016	A previously unrecognized arginine-rich motif in Dysf is crucial for PS accumulation.	Phosphatidylserines	69-71	dysferlin	Homo sapiens	49-53
27485601-1	2016	We previously reported a unique peptide-peptoid hybrid, PPS1 that specifically recognizes lipid-phosphatidylserine (PS) and a few other negatively charged phospholipids, but not neutral phospholipids, on the cell membrane.	Phosphatidylserines	96-114	interferon regulatory factor 6	Homo sapiens	56-60
27262539-5	2016	Our studies have shown significant differences in apoptotic cells by chromatin condensation, formation of apoptotic bodies and exposure of phosphatidylserine (PS) on the extracellular surface when the cells where treated with a potent Bcl-2 family inhibitor drug (ABT-263).	Phosphatidylserines	139-157	BCL2 apoptosis regulator	Homo sapiens	235-240
27262539-5	2016	Our studies have shown significant differences in apoptotic cells by chromatin condensation, formation of apoptotic bodies and exposure of phosphatidylserine (PS) on the extracellular surface when the cells where treated with a potent Bcl-2 family inhibitor drug (ABT-263).	Phosphatidylserines	159-161	BCL2 apoptosis regulator	Homo sapiens	235-240
27584039-8	2016	Both PS and PE -containing membranes supported the formation of a fXa-PZ complex.	Phosphatidylserines	5-7	coagulation factor X	Homo sapiens	66-69
27499046-7	2016	PS exposure was significantly lower in Galphai2(-/-) than in Galphai2(+/+) erythrocytes following ex vivo exposure to hyperosmotic shock, bacterial sphingomyelinase or C6 ceramide.	Phosphatidylserines	0-2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	Mus musculus	39-47
27499046-7	2016	PS exposure was significantly lower in Galphai2(-/-) than in Galphai2(+/+) erythrocytes following ex vivo exposure to hyperosmotic shock, bacterial sphingomyelinase or C6 ceramide.	Phosphatidylserines	0-2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	Mus musculus	61-69
27235400-6	2016	However, the neo1-1(ts) and neo1-2(ts) mutants display a loss of PS and PE asymmetry at permissive growth temperatures as measured by hypersensitivity to pore-forming toxins that target PS (papuamide A) or PE (duramycin) exposed in the extracellular leaflet.	Phosphatidylserines	65-67	putative aminophospholipid-translocating P4-type ATPase NEO1	Saccharomyces cerevisiae S288C	13-17
27235400-6	2016	However, the neo1-1(ts) and neo1-2(ts) mutants display a loss of PS and PE asymmetry at permissive growth temperatures as measured by hypersensitivity to pore-forming toxins that target PS (papuamide A) or PE (duramycin) exposed in the extracellular leaflet.	Phosphatidylserines	65-67	putative aminophospholipid-translocating P4-type ATPase NEO1	Saccharomyces cerevisiae S288C	28-32
27383986-6	2016	GSDMD-NT binds to phosphatidylinositol phosphates and phosphatidylserine (restricted to the cell membrane inner leaflet) and cardiolipin (present in the inner and outer leaflets of bacterial membranes).	Phosphatidylserines	54-72	gasdermin D	Homo sapiens	0-5
27354379-3	2016	Here, we provide evidence that Ups2-Mdm35, a protein complex localized at the mitochondrial intermembrane space, mediates PS transport for PE synthesis in respiration-active mitochondria.	Phosphatidylserines	122-124	Ups2p	Saccharomyces cerevisiae S288C	31-35
27354379-3	2016	Here, we provide evidence that Ups2-Mdm35, a protein complex localized at the mitochondrial intermembrane space, mediates PS transport for PE synthesis in respiration-active mitochondria.	Phosphatidylserines	122-124	Mdm35p	Saccharomyces cerevisiae S288C	36-41
27075190-8	2016	We found that mammalian Hsp70 displayed a high specificity for negatively charged phospholipids, such as phosphatidyl serine, whereas DnaK interacted with all lipids tested regardless of the charge.	Phosphatidylserines	105-124	heat shock protein family A (Hsp70) member 4	Homo sapiens	24-29
27277390-1	2016	We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively.	Phosphatidylserines	153-171	ATPase phospholipid transporting 10A (putative)	Homo sapiens	38-44
27277390-1	2016	We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively.	Phosphatidylserines	153-171	ATPase phospholipid transporting 8B1	Homo sapiens	45-51
27277390-1	2016	We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively.	Phosphatidylserines	153-171	ATPase phospholipid transporting 11A	Homo sapiens	57-63
27277390-1	2016	We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively.	Phosphatidylserines	153-171	ATPase phospholipid transporting 11C	Homo sapiens	64-70
27277390-1	2016	We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively.	Phosphatidylserines	173-175	ATPase phospholipid transporting 10A (putative)	Homo sapiens	38-44
27277390-1	2016	We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively.	Phosphatidylserines	173-175	ATPase phospholipid transporting 8B1	Homo sapiens	45-51
27277390-1	2016	We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively.	Phosphatidylserines	173-175	ATPase phospholipid transporting 11A	Homo sapiens	57-63
27277390-1	2016	We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively.	Phosphatidylserines	173-175	ATPase phospholipid transporting 11C	Homo sapiens	64-70
30480416-6	2016	Revealed impairments in the cellular link of the immune system were associated with an increase in splenocytes apoptosis, which was detected by Annexin V-GFP ability to bind phosphatidyl serine that is specifically located on the outer surface of plasmalemma in apoptosis.	Phosphatidylserines	174-193	annexin A5	Homo sapiens	144-153
27267274-2	2016	Aminophospholipids, notably phosphatidylserine (PS), are confined to the inner leaflet of the erythrocyte membrane lipid bilayer by the ATP-dependent flippase enzyme, ATP11C, counteracting the activity of an ATP-independent scramblase.	Phosphatidylserines	28-46	ATPase phospholipid transporting 11C	Homo sapiens	167-173
27267274-2	2016	Aminophospholipids, notably phosphatidylserine (PS), are confined to the inner leaflet of the erythrocyte membrane lipid bilayer by the ATP-dependent flippase enzyme, ATP11C, counteracting the activity of an ATP-independent scramblase.	Phosphatidylserines	48-50	ATPase phospholipid transporting 11C	Homo sapiens	167-173
27348126-1	2016	Exposure of phosphatidylserine (PS) on the outer leaflet of the cell membrane is thought to play a critical role in tissue factor (TF) decryption.	Phosphatidylserines	12-30	coagulation factor III, tissue factor	Homo sapiens	116-129
27348126-1	2016	Exposure of phosphatidylserine (PS) on the outer leaflet of the cell membrane is thought to play a critical role in tissue factor (TF) decryption.	Phosphatidylserines	12-30	coagulation factor III, tissue factor	Homo sapiens	131-133
27348126-10	2016	However, our data also indicate that TF regions outside of the putative lipid binding region may also contribute to PS-dependent decryption of TF.	Phosphatidylserines	116-118	coagulation factor III, tissue factor	Homo sapiens	37-39
27348126-10	2016	However, our data also indicate that TF regions outside of the putative lipid binding region may also contribute to PS-dependent decryption of TF.	Phosphatidylserines	116-118	coagulation factor III, tissue factor	Homo sapiens	143-145
27241913-4	2016	Second, Psd1 decarboxylates PS in the outer membrane in trans, independently of PS transfer by Ups2-Mdm35.	Phosphatidylserines	28-30	pleckstrin and Sec7 domain containing	Homo sapiens	8-12
27260166-10	2016	Interestingly, both apocynin and annexin V (used as inhibitor of PS-induced phagocytosis) fully abolished the DA neurotoxicity induced by the injection of histamine in the SN of adult mice in vivo.	Phosphatidylserines	65-67	annexin A5	Mus musculus	33-42
26245757-8	2016	Neutrophils infiltrating the peritoneum in response to C5a released phosphatidylserine (PS)-positive PMN-Ecto early on in the course of inflammation.	Phosphatidylserines	68-86	complement C5a receptor 1	Homo sapiens	55-58
26245757-8	2016	Neutrophils infiltrating the peritoneum in response to C5a released phosphatidylserine (PS)-positive PMN-Ecto early on in the course of inflammation.	Phosphatidylserines	68-86	tripartite motif containing 33	Homo sapiens	105-109
26245757-8	2016	Neutrophils infiltrating the peritoneum in response to C5a released phosphatidylserine (PS)-positive PMN-Ecto early on in the course of inflammation.	Phosphatidylserines	88-90	complement C5a receptor 1	Homo sapiens	55-58
26245757-8	2016	Neutrophils infiltrating the peritoneum in response to C5a released phosphatidylserine (PS)-positive PMN-Ecto early on in the course of inflammation.	Phosphatidylserines	88-90	tripartite motif containing 33	Homo sapiens	105-109
27174501-8	2016	Given our previous finding that Stab2 recognizes PS exposed on apoptotic cells for sensing as an "eat-me" signal, we propose that PS-Stab2 binding is required for sensing of a "fuse-me" signal as the initial signal of myoblast fusion.	Phosphatidylserines	49-51	stabilin 2	Mus musculus	32-37
27174501-8	2016	Given our previous finding that Stab2 recognizes PS exposed on apoptotic cells for sensing as an "eat-me" signal, we propose that PS-Stab2 binding is required for sensing of a "fuse-me" signal as the initial signal of myoblast fusion.	Phosphatidylserines	49-51	stabilin 2	Mus musculus	133-138
26496826-5	2016	The results showed that erythrocyte shrinkage, annexin-V binding to externalized PS on the membrane of early-stage apoptotic cells, the increased membrane roughness and intracellular Ca(2+) concentration, as well as the change of distributions of band 3 protein in RBCs.	Phosphatidylserines	81-83	annexin A5	Homo sapiens	47-56
27120792-7	2016	Further we found that the dimeric version of PPS1 (PPS1D1) displayed strong cytotoxicity towards lung cancer cell lines that externalize PS, but not normal cells.	Phosphatidylserines	46-48	interferon regulatory factor 6	Homo sapiens	51-57
27161080-2	2016	Here we present evidence that surface exposure of phosphatidylserine (PS) is pivotal for ADAM17 to exert sheddase activity.	Phosphatidylserines	50-68	ADAM metallopeptidase domain 17	Homo sapiens	89-95
27161080-3	2016	PS exposure is tightly coupled to substrate shedding provoked by diverse ADAM17 activators.	Phosphatidylserines	0-2	ADAM metallopeptidase domain 17	Homo sapiens	73-79
27036911-5	2016	We show that calreticulin, via its C-terminal acidic region, preferentially interacts with phosphatidylserine (PS) compared with other phospholipids and that this interaction is calcium dependent.	Phosphatidylserines	91-109	calreticulin	Mus musculus	13-25
27036911-5	2016	We show that calreticulin, via its C-terminal acidic region, preferentially interacts with phosphatidylserine (PS) compared with other phospholipids and that this interaction is calcium dependent.	Phosphatidylserines	111-113	calreticulin	Mus musculus	13-25
27044099-5	2016	Conversely, inhibitors of PI4KA, the enzyme that makes PI4P in the PM, blocked PS synthesis and reduced PS levels by 50% in normal cells.	Phosphatidylserines	79-81	phosphatidylinositol 4-kinase alpha	Homo sapiens	26-31
27044099-5	2016	Conversely, inhibitors of PI4KA, the enzyme that makes PI4P in the PM, blocked PS synthesis and reduced PS levels by 50% in normal cells.	Phosphatidylserines	104-106	phosphatidylinositol 4-kinase alpha	Homo sapiens	26-31
27040328-9	2016	We also show the differential binding of CD300a and CD300c to their ligands phosphatidylethanolamine (PE) and phosphatidylserine (PS) and their differential ability to affect CD56(bright) NK cell functions.	Phosphatidylserines	110-128	CD300a molecule	Homo sapiens	41-47
27040328-9	2016	We also show the differential binding of CD300a and CD300c to their ligands phosphatidylethanolamine (PE) and phosphatidylserine (PS) and their differential ability to affect CD56(bright) NK cell functions.	Phosphatidylserines	110-128	CD300c molecule	Homo sapiens	52-58
27040328-9	2016	We also show the differential binding of CD300a and CD300c to their ligands phosphatidylethanolamine (PE) and phosphatidylserine (PS) and their differential ability to affect CD56(bright) NK cell functions.	Phosphatidylserines	130-132	CD300a molecule	Homo sapiens	41-47
27040328-9	2016	We also show the differential binding of CD300a and CD300c to their ligands phosphatidylethanolamine (PE) and phosphatidylserine (PS) and their differential ability to affect CD56(bright) NK cell functions.	Phosphatidylserines	130-132	CD300c molecule	Homo sapiens	52-58
27040328-9	2016	We also show the differential binding of CD300a and CD300c to their ligands phosphatidylethanolamine (PE) and phosphatidylserine (PS) and their differential ability to affect CD56(bright) NK cell functions.	Phosphatidylserines	130-132	neural cell adhesion molecule 1	Homo sapiens	175-179
26769675-0	2016	Phosphatidylserine enhances IKBKAP transcription by activating the MAPK/ERK signaling pathway.	Phosphatidylserines	0-18	elongator acetyltransferase complex subunit 1	Homo sapiens	28-34
26769675-0	2016	Phosphatidylserine enhances IKBKAP transcription by activating the MAPK/ERK signaling pathway.	Phosphatidylserines	0-18	mitogen-activated protein kinase 1	Homo sapiens	72-75
26769675-5	2016	We show that PS treatment enhanced ERK phosphorylation in cells derived from FD patients.	Phosphatidylserines	13-15	mitogen-activated protein kinase 1	Homo sapiens	35-38
26769675-9	2016	In conclusion, our results demonstrate that PS activates the MAPK/ERK signaling pathway, resulting in activation of transcription factors that bind the promoter region of IKBKAP and thus enhancing its transcription.	Phosphatidylserines	44-46	mitogen-activated protein kinase 1	Homo sapiens	66-69
26769675-9	2016	In conclusion, our results demonstrate that PS activates the MAPK/ERK signaling pathway, resulting in activation of transcription factors that bind the promoter region of IKBKAP and thus enhancing its transcription.	Phosphatidylserines	44-46	elongator acetyltransferase complex subunit 1	Homo sapiens	171-177
26660948-8	2016	Blockade of PS with lactadherin prolonged coagulation time, decreased fibrin formation to control levels, and inhibited the procoagulant enzymes production in the MPs and MP-origin cells.	Phosphatidylserines	12-14	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	20-31
26774912-4	2016	Here we report that cell preconditioning with an optimal dose (1-5 muM) of HT prior to exposure to 2.5 muM HgCl2 causes a noteworthy decrease in PS-exposing RBC, almost restoring ATP and GSH content.	Phosphatidylserines	145-147	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	157-160
26513704-8	2016	Importantly, confocal imaging of MPs or septic serum-treated ECs identified binding sites for FVa and FXa to form prothrombinase, and further supported fibrin formation in the area where PS exposure was abundant.	Phosphatidylserines	187-189	coagulation factor X	Homo sapiens	102-105
26926787-6	2016	Furthermore, the P17 binding was correlated with the apoptotic feature of phosphatidylserine (PS) exposure and caspase-3 activation.	Phosphatidylserines	74-92	family with sequence similarity 72, member A	Mus musculus	17-20
26926787-6	2016	Furthermore, the P17 binding was correlated with the apoptotic feature of phosphatidylserine (PS) exposure and caspase-3 activation.	Phosphatidylserines	94-96	family with sequence similarity 72, member A	Mus musculus	17-20
26928672-5	2016	Using Annexin V (AV) and Shiga toxin B subunit (ST) with affinities for phosphatidylserine and globotriaosylceramide, respectively, AV- and a ST-binding EV were identified.	Phosphatidylserines	72-90	annexin A5	Homo sapiens	6-15
26836284-6	2016	It has been demonstrated that a mutation of proline 135 located in the C-terminus of FGF1 results in (i) partial unfolding of FGF1, (ii) a decrease in FGF1"s ability to permeabilize bilayers composed of phosphatidylserine, and (iii) drastic inhibition of stress-induced FGF1 export.	Phosphatidylserines	203-221	fibroblast growth factor 1	Homo sapiens	85-89
26481309-7	2016	Platelets from the surviving Ano6-deficient mice resembled platelets from patients with Scott syndrome in: 1) normal collagen-induced aggregate formation (P > 0.05) with reduced PS exposure (-65 to 90%); 2) lowered Ca(2+)-dependent swelling (-80%) and membrane blebbing (-90%); 3) reduced calpain-dependent protein cleavage (-60%); and 4) moderately affected apoptosis-dependent PS exposure.	Phosphatidylserines	181-183	anoctamin 6	Mus musculus	29-33
32262958-11	2016	According to the calculated free energies and the cellular uptake of TIM4-functionalized NPs, it seems that the TIM4/PS complex releases enough free energy to induce endocytosis.	Phosphatidylserines	117-119	T cell immunoglobulin and mucin domain containing 4	Homo sapiens	69-73
32262958-11	2016	According to the calculated free energies and the cellular uptake of TIM4-functionalized NPs, it seems that the TIM4/PS complex releases enough free energy to induce endocytosis.	Phosphatidylserines	117-119	T cell immunoglobulin and mucin domain containing 4	Homo sapiens	112-116
26799398-5	2016	Loss of ATP11C resulted in a defective internalization of phosphatidylserine (PS) and phosphatidylethanolamine (PE) in comparison to control cells.	Phosphatidylserines	58-76	ATPase, class VI, type 11C	Mus musculus	8-14
26799398-5	2016	Loss of ATP11C resulted in a defective internalization of phosphatidylserine (PS) and phosphatidylethanolamine (PE) in comparison to control cells.	Phosphatidylserines	78-80	ATPase, class VI, type 11C	Mus musculus	8-14
26799398-6	2016	The diminished flippase activity caused increased PS exposure on 7-aminoactinomycin D- (7-AAD-) viable pro-B cells freshly isolated from the bone marrow of ATP11C-deficient mice, which was corrected upon a 2-hour resting period in vitro.	Phosphatidylserines	50-52	ATPase, class VI, type 11C	Mus musculus	156-162
27287398-4	2016	Furthermore, the results of PS exposure depended on the fluorescent dye used (annexin V-FITC versus annexin V alexa fluor  647).	Phosphatidylserines	28-30	annexin A5	Homo sapiens	78-87
27287398-4	2016	Furthermore, the results of PS exposure depended on the fluorescent dye used (annexin V-FITC versus annexin V alexa fluor  647).	Phosphatidylserines	28-30	annexin A5	Homo sapiens	100-109
27607238-3	2016	Phosphatidylserine (PS) extroversion rate was detected by Annexin V binding.	Phosphatidylserines	0-18	annexin A5	Homo sapiens	58-67
27771709-13	2016	CONCLUSION: PS exposure is mediated by the Ca2+-dependent scramblase but also by PKCalpha activated by LPA and PMA in a Ca2+-dependent and a Ca2+-independent manner.	Phosphatidylserines	12-14	protein kinase C alpha	Homo sapiens	81-89
26689775-4	2016	In this study, we introduce alpha-tocopherol and phosphatidylserine (PS) containing liposomes (PST-liposomes) to inhibit the microglial inflammatory response.	Phosphatidylserines	49-67	sulfotransferase family 1A member 1	Homo sapiens	95-98
26689775-4	2016	In this study, we introduce alpha-tocopherol and phosphatidylserine (PS) containing liposomes (PST-liposomes) to inhibit the microglial inflammatory response.	Phosphatidylserines	69-71	sulfotransferase family 1A member 1	Homo sapiens	95-98
26596643-6	2016	Additionally, the cytotoxicity of temporin-1CEa against A375 cells can be ameliorated by annexin V, which binds to cell surface PS with high affinity.	Phosphatidylserines	128-130	annexin A5	Homo sapiens	89-98
27108428-2	2016	It also allows to visualize the process of apoptosis, by using radiolabeled compounds such as Annexin V, that bind to extracellular phosphatidylserine (PS).	Phosphatidylserines	132-150	annexin A5	Homo sapiens	94-103
27108428-2	2016	It also allows to visualize the process of apoptosis, by using radiolabeled compounds such as Annexin V, that bind to extracellular phosphatidylserine (PS).	Phosphatidylserines	152-154	annexin A5	Homo sapiens	94-103
26443863-1	2015	Phosphatidylethanolamine (PE) in the yeast Saccharomyces cerevisiae is synthesized through decarboxylation of phosphatidylserine (PS), catalysed by PS decarboxylase 1 (Psd1p) and 2 (Psd2p) and the cytidine 5"-diphosphate (CDP)-ethanolamine (CDP-Etn) pathway.	Phosphatidylserines	110-128	phosphatidylserine decarboxylase 1	Saccharomyces cerevisiae S288C	168-173
26443863-1	2015	Phosphatidylethanolamine (PE) in the yeast Saccharomyces cerevisiae is synthesized through decarboxylation of phosphatidylserine (PS), catalysed by PS decarboxylase 1 (Psd1p) and 2 (Psd2p) and the cytidine 5"-diphosphate (CDP)-ethanolamine (CDP-Etn) pathway.	Phosphatidylserines	110-128	phosphatidylserine decarboxylase 2	Saccharomyces cerevisiae S288C	182-187
26443863-1	2015	Phosphatidylethanolamine (PE) in the yeast Saccharomyces cerevisiae is synthesized through decarboxylation of phosphatidylserine (PS), catalysed by PS decarboxylase 1 (Psd1p) and 2 (Psd2p) and the cytidine 5"-diphosphate (CDP)-ethanolamine (CDP-Etn) pathway.	Phosphatidylserines	130-132	phosphatidylserine decarboxylase 1	Saccharomyces cerevisiae S288C	168-173
26443863-1	2015	Phosphatidylethanolamine (PE) in the yeast Saccharomyces cerevisiae is synthesized through decarboxylation of phosphatidylserine (PS), catalysed by PS decarboxylase 1 (Psd1p) and 2 (Psd2p) and the cytidine 5"-diphosphate (CDP)-ethanolamine (CDP-Etn) pathway.	Phosphatidylserines	130-132	phosphatidylserine decarboxylase 2	Saccharomyces cerevisiae S288C	182-187
26443863-8	2015	Deletion of VID22 in wild-type and PSD1-depressed cells caused partial defects in PE formation through decarboxylation of PS.	Phosphatidylserines	35-37	Vid22p	Saccharomyces cerevisiae S288C	12-17
26391841-8	2015	ADP stimulation of P2Y12 led to cAMP decrease that, in turn, caused changes in phospholipase C phosphorylation by protein kinase A, increase in cytoplasmic calcium level and, consequently, PS+ platelet formation.	Phosphatidylserines	189-192	purinergic receptor P2Y12	Homo sapiens	19-24
27073733-6	2016	The phagocytic receptor CED-1 is activated through interaction with its ligand phosphatidylserine (PS), exposed on the surface of necrotic cells.	Phosphatidylserines	79-97	intraflagellar transport 122	Homo sapiens	24-29
27073733-6	2016	The phagocytic receptor CED-1 is activated through interaction with its ligand phosphatidylserine (PS), exposed on the surface of necrotic cells.	Phosphatidylserines	99-101	intraflagellar transport 122	Homo sapiens	24-29
26572827-3	2016	We found that fendiline, a potent ASM inhibitor, reduces the phosphatidylserine (PtdSer) and cholesterol content of the inner plasma membrane.	Phosphatidylserines	61-79	sphingomyelin phosphodiesterase 1	Homo sapiens	34-37
26580207-9	2015	Further, exposure of PS in uremia resulted in increased generation of FXa, thrombin, and fibrin and significantly shortened coagulation time.	Phosphatidylserines	21-23	coagulation factor X	Homo sapiens	70-73
26580207-9	2015	Further, exposure of PS in uremia resulted in increased generation of FXa, thrombin, and fibrin and significantly shortened coagulation time.	Phosphatidylserines	21-23	coagulation factor II, thrombin	Homo sapiens	75-83
26235126-2	2015	In this paper we compare the results from the Annexin-V assay with electrophysiology data obtained in parallel using dielectrophoresis, which highlights two changes in cell electrophysiology; a change in cytoplasmic conductivity which correlates with PS expression, and a membrane conductance spike that correlates with permeabilisation.	Phosphatidylserines	251-253	annexin A5	Homo sapiens	46-55
26420878-2	2015	We and others previously showed that ATP11C, a member of the P4-ATPases, translocates phosphatidylserine (PS) at the plasma membrane.	Phosphatidylserines	86-104	phospholipid-transporting ATPase IG	Cricetulus griseus	37-43
26420878-2	2015	We and others previously showed that ATP11C, a member of the P4-ATPases, translocates phosphatidylserine (PS) at the plasma membrane.	Phosphatidylserines	106-108	phospholipid-transporting ATPase IG	Cricetulus griseus	37-43
26420878-8	2015	Moreover, exogenous expression of ATP11C can restore PS uptake in UPS-1 cells.	Phosphatidylserines	53-55	ATPase phospholipid transporting 11C	Homo sapiens	34-40
26420878-9	2015	These results indicate that lack of the functional ATP11C protein is responsible for the defect in PS uptake in UPS-1 cells and ATP11C is crucial for PS flipping in CHO-K1 cells.	Phosphatidylserines	99-101	phospholipid-transporting ATPase IG	Cricetulus griseus	51-57
26205076-6	2015	RESULTS: Peptides LIKKPF and PGDLSR inhibited binding of (64)Cu-labeled annexin-V to immobilized PS in the millimolar range (IC50 10-15 mM) compared to annexin-V (45 nM).	Phosphatidylserines	97-99	annexin A5	Homo sapiens	72-81
26205076-6	2015	RESULTS: Peptides LIKKPF and PGDLSR inhibited binding of (64)Cu-labeled annexin-V to immobilized PS in the millimolar range (IC50 10-15 mM) compared to annexin-V (45 nM).	Phosphatidylserines	97-99	annexin A5	Homo sapiens	152-161
26205076-15	2015	This may explained by the relatively low potency of both compounds to compete with binding of (64)Cu-labeled annexin-V to PS.	Phosphatidylserines	122-124	annexin A5	Homo sapiens	109-118
26205076-16	2015	Overall the novel competitive radiometric PS-binding assay with (64)Cu-labeled annexin-V represents a versatile and very robust screening platform to analyze potential PS-binding compounds in vitro.	Phosphatidylserines	42-44	annexin A5	Homo sapiens	79-88
26205076-16	2015	Overall the novel competitive radiometric PS-binding assay with (64)Cu-labeled annexin-V represents a versatile and very robust screening platform to analyze potential PS-binding compounds in vitro.	Phosphatidylserines	168-170	annexin A5	Homo sapiens	79-88
26516916-5	2015	Phosphatidylserine (PS) exposure of RBCs and their microparticles (MPs) release were labeled with Alexa Fluor 488-lactadherin and detected by flow cytometer.	Phosphatidylserines	0-18	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	114-125
26516916-5	2015	Phosphatidylserine (PS) exposure of RBCs and their microparticles (MPs) release were labeled with Alexa Fluor 488-lactadherin and detected by flow cytometer.	Phosphatidylserines	20-22	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	114-125
26272944-9	2015	Blocking the accessible PS with the PS-binding domain of lactadherin strongly inhibited non-endocytic R9 entry, suggesting the importance of PS externalization in this process.	Phosphatidylserines	24-26	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	57-68
26272944-9	2015	Blocking the accessible PS with the PS-binding domain of lactadherin strongly inhibited non-endocytic R9 entry, suggesting the importance of PS externalization in this process.	Phosphatidylserines	36-38	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	57-68
26374481-2	2015	This study tested the hypothesis that n-3 PUFAs enhance Akt-dependent prosurvival signaling by promoting the biosynthesis of phosphatidylserine in neuronal cell membranes.	Phosphatidylserines	125-143	AKT serine/threonine kinase 1	Rattus norvegicus	56-59
26162408-4	2015	Less than 10% of fVIII was displaced from thrombin-stimulated platelets by lactadherin, a PS-binding protein, and an fVIII mutant defective in PS-dependent binding retained platelet affinity.	Phosphatidylserines	90-92	coagulation factor VIII	Homo sapiens	17-22
26331251-8	2015	Therefore, PS and PE lipids synergistically combine to enhance membrane poration by MP1, implying that the combined enrichment of both these lipids in the outer leaflet of cancer cells is highly significant for MP1"s anticancer action.	Phosphatidylserines	11-13	pitrilysin metallopeptidase 1	Homo sapiens	84-87
26331251-8	2015	Therefore, PS and PE lipids synergistically combine to enhance membrane poration by MP1, implying that the combined enrichment of both these lipids in the outer leaflet of cancer cells is highly significant for MP1"s anticancer action.	Phosphatidylserines	11-13	pitrilysin metallopeptidase 1	Homo sapiens	211-214
26205155-11	2015	CONCLUSIONS: In addition to induction of apoptosis/necrosis with PS-mediated activation of preformed TF, cisplatin may alter the procoagulant phenotype of GCT cells through an increase in total cellular TF antigen.	Phosphatidylserines	65-67	coagulation factor III, tissue factor	Homo sapiens	101-103
26345866-8	2015	In AD rats, PS treatment reduced the escape latent period of AD rats, increased SOD and OH(-), and decreased acetylcholinesterase levels (P < 0.05).	Phosphatidylserines	12-14	acetylcholinesterase	Rattus norvegicus	109-129
26345866-11	2015	In conclusion, PS decreased cholinesterase, improved memory, and improved hippocampal inflammation injury in AD brains by increasing SOD and OH(-) levels.	Phosphatidylserines	15-17	butyrylcholinesterase	Rattus norvegicus	28-42
26038127-0	2015	Exposure of FVIII in the Presence of Phosphatidyl Serine Reduces Generation of Memory B-Cells and Induces Regulatory T-Cell-Mediated Hyporesponsiveness in Hemophilia A Mice.	Phosphatidylserines	37-56	coagulation factor VIII	Mus musculus	12-17
26038127-2	2015	Previous studies showed that administration of FVIII in the presence of phosphatidyl serine (PS) reduced the development of anti-FVIII antibodies in HA mice.	Phosphatidylserines	72-91	coagulation factor VIII	Mus musculus	47-52
26038127-2	2015	Previous studies showed that administration of FVIII in the presence of phosphatidyl serine (PS) reduced the development of anti-FVIII antibodies in HA mice.	Phosphatidylserines	72-91	coagulation factor VIII	Mus musculus	129-134
26038127-2	2015	Previous studies showed that administration of FVIII in the presence of phosphatidyl serine (PS) reduced the development of anti-FVIII antibodies in HA mice.	Phosphatidylserines	93-95	coagulation factor VIII	Mus musculus	47-52
26038127-2	2015	Previous studies showed that administration of FVIII in the presence of phosphatidyl serine (PS) reduced the development of anti-FVIII antibodies in HA mice.	Phosphatidylserines	93-95	coagulation factor VIII	Mus musculus	129-134
26038127-10	2015	This demonstrates that PS reduces immunologic memory of FVIII and induces antigen-specific peripheral tolerance in HA mice.	Phosphatidylserines	23-25	coagulation factor VIII	Mus musculus	56-61
25823581-2	2015	Activation of the P2X7 receptor by extracellular adenosine 5"-triphosphate (ATP) can induce PS exposure on freshly isolated human RBCs, but whether this process occurs in stored RBCs or changes during RBC aging is unknown.	Phosphatidylserines	92-94	purinergic receptor P2X 7	Homo sapiens	18-31
26101831-8	2015	Delipidated NAP-22 bound phosphatidylserine (PS), phosphatidylinosotol, and ganglioside.	Phosphatidylserines	25-43	brain abundant membrane attached signal protein 1	Homo sapiens	12-18
26101831-8	2015	Delipidated NAP-22 bound phosphatidylserine (PS), phosphatidylinosotol, and ganglioside.	Phosphatidylserines	45-47	brain abundant membrane attached signal protein 1	Homo sapiens	12-18
26101831-9	2015	Some part of the mixture of PS and NAP-22 was recovered in the insoluble fraction after Triton X-100 treatment and the addition of cholesterol enhanced the amount of NAP-22 in the insoluble fraction.	Phosphatidylserines	28-30	brain abundant membrane attached signal protein 1	Homo sapiens	166-172
26112625-4	2015	To demonstrate the differences in the procoagulatory efficacy of TF-derivative tTF-NGR on binding to HUVECs with a low versus high surface concentration of PS, we performed factor X activation assays.	Phosphatidylserines	156-158	reticulon 4 receptor	Mus musculus	83-86
26061275-8	2015	The extracellular domain of CED-1 associates with PS in vitro.	Phosphatidylserines	50-52	Cell death abnormality protein 1	Caenorhabditis elegans	28-33
26061275-11	2015	The combined activities from CED-7 and ANOH-1 ensure efficient exposure of PS on necrotic cells to attract their phagocytes.	Phosphatidylserines	75-77	ABC transporter ced-7	Caenorhabditis elegans	29-34
26061275-11	2015	The combined activities from CED-7 and ANOH-1 ensure efficient exposure of PS on necrotic cells to attract their phagocytes.	Phosphatidylserines	75-77	Anoctamin	Caenorhabditis elegans	39-45
25691235-8	2015	Phosphatidylserine concentration in milk was also affected by cycle day by treatment interaction (P=0.04).	Phosphatidylserines	0-18	Weaning weight-maternal milk	Bos taurus	36-40
25911756-10	2015	Blocking CD300a interaction with PS by injection of a neutralizing anti-CD300a Ab resulted in inhibition of the development of allergic airway inflammation.	Phosphatidylserines	33-35	CD300A molecule	Mus musculus	9-15
25911756-10	2015	Blocking CD300a interaction with PS by injection of a neutralizing anti-CD300a Ab resulted in inhibition of the development of allergic airway inflammation.	Phosphatidylserines	33-35	CD300A molecule	Mus musculus	72-78
25980030-4	2015	The finding that CD300a recognizes phosphatidylserine and phosphatidylethanolamine, two aminophospholipids exposed on the outer leaflet of dead and activated cells, has shed new light on its role in the modulation of immune functions and in its participation in the host response to several diseases states, such as infectious diseases, cancer, allergy, and chronic inflammatory diseases.	Phosphatidylserines	35-53	CD300a molecule	Homo sapiens	17-23
25665862-6	2015	Annexin V"s great affinity for PS allows it to bond to it forming a shield that blocks both of these actions suggesting that its therapeutic administration during a sickle crisis may be able to hasten its termination.	Phosphatidylserines	31-33	annexin A5	Homo sapiens	0-9
25915718-5	2015	To this end phosphatidylserine exposure at the cell surface was estimated from annexin V binding, cell volume from forward scatter, red blood cell distribution width (RDW) from electronic particle counting, reactive oxidant species (ROS) from 2",7"-dichlorodihydrofluorescein diacetate (DCFDA) fluorescence, [Ca2+]i from Fluo3- and Fluo4 fluorescence, and ceramide abundance from binding of specific antibodies.	Phosphatidylserines	12-30	annexin A5	Homo sapiens	79-88
25712989-6	2015	Flow cytometry revealed that stimulation of platelets with thrombin/convulxin significantly increased the plasminogen signal associated with phosphatidylserine (PS)-exposing platelets.	Phosphatidylserines	141-159	coagulation factor II, thrombin	Homo sapiens	59-67
25712989-6	2015	Flow cytometry revealed that stimulation of platelets with thrombin/convulxin significantly increased the plasminogen signal associated with phosphatidylserine (PS)-exposing platelets.	Phosphatidylserines	141-159	plasminogen	Homo sapiens	106-117
25712989-6	2015	Flow cytometry revealed that stimulation of platelets with thrombin/convulxin significantly increased the plasminogen signal associated with phosphatidylserine (PS)-exposing platelets.	Phosphatidylserines	161-163	coagulation factor II, thrombin	Homo sapiens	59-67
25712989-6	2015	Flow cytometry revealed that stimulation of platelets with thrombin/convulxin significantly increased the plasminogen signal associated with phosphatidylserine (PS)-exposing platelets.	Phosphatidylserines	161-163	plasminogen	Homo sapiens	106-117
25790164-2	2015	Here, neutron reflectometry (NR) and fluorescence spectroscopy were employed to uncover molecular details of the interaction between alpha-syn and two anionic lipids, phosphatidic acid (PA) and phosphatidylserine (PS).	Phosphatidylserines	194-212	synuclein alpha	Homo sapiens	133-142
25790164-2	2015	Here, neutron reflectometry (NR) and fluorescence spectroscopy were employed to uncover molecular details of the interaction between alpha-syn and two anionic lipids, phosphatidic acid (PA) and phosphatidylserine (PS).	Phosphatidylserines	214-216	synuclein alpha	Homo sapiens	133-142
25645598-6	2015	However, B cells that express a mutant form of TIM-1 lacking the mucin domain (TIM-1(Deltamucin) ) exhibit decreased phosphatidylserine binding and are unable to produce IL-10 in response to ACs or by specific ligation with anti-TIM-1.	Phosphatidylserines	117-135	hepatitis A virus cellular receptor 1	Mus musculus	47-52
25645598-6	2015	However, B cells that express a mutant form of TIM-1 lacking the mucin domain (TIM-1(Deltamucin) ) exhibit decreased phosphatidylserine binding and are unable to produce IL-10 in response to ACs or by specific ligation with anti-TIM-1.	Phosphatidylserines	117-135	hepatitis A virus cellular receptor 1	Mus musculus	79-84
25645598-6	2015	However, B cells that express a mutant form of TIM-1 lacking the mucin domain (TIM-1(Deltamucin) ) exhibit decreased phosphatidylserine binding and are unable to produce IL-10 in response to ACs or by specific ligation with anti-TIM-1.	Phosphatidylserines	117-135	hepatitis A virus cellular receptor 1	Mus musculus	79-84
25572019-3	2015	Recent studies demonstrate that both soluble PS and PS-containing model membranes promote formation of inactive fXa dimers at 5 mM Ca2+.	Phosphatidylserines	45-47	coagulation factor X	Homo sapiens	112-115
25572019-3	2015	Recent studies demonstrate that both soluble PS and PS-containing model membranes promote formation of inactive fXa dimers at 5 mM Ca2+.	Phosphatidylserines	52-54	coagulation factor X	Homo sapiens	112-115
25363158-4	2015	PSS1 promotes the biosynthesis of phosphatidylserine (PTDS), which is a functional constituent of lipid bilayers.	Phosphatidylserines	34-52	phosphatidylserine synthase 1	Homo sapiens	0-4
25363158-4	2015	PSS1 promotes the biosynthesis of phosphatidylserine (PTDS), which is a functional constituent of lipid bilayers.	Phosphatidylserines	54-58	phosphatidylserine synthase 1	Homo sapiens	0-4
25665597-3	2015	We combined the specificity of Annexin-V for phosphatidylserine, a phospholipid expressed in the outer membrane of apoptotic cells, with the optical and electrochemical properties of quantum dots to create a more efficient label.	Phosphatidylserines	45-63	annexin A5	Homo sapiens	31-40
25595798-4	2015	Depletion of ATP8A1 impaired the asymmetric transbilayer distribution of PS in REs, dissociated EHD1 from REs, and generated aberrant endosomal tubules that appear resistant to fission.	Phosphatidylserines	73-75	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	Mus musculus	13-19
25348269-4	2015	METHODS: The concentration of PS-exposing EVs in platelet-free plasma (PFP) of healthy subjects was measured by FCM using either light scattering or fluorescence as the trigger and fluorescent Annexin-5 (Anx5) as the specific label.	Phosphatidylserines	30-32	annexin A5	Homo sapiens	193-202
25348269-4	2015	METHODS: The concentration of PS-exposing EVs in platelet-free plasma (PFP) of healthy subjects was measured by FCM using either light scattering or fluorescence as the trigger and fluorescent Annexin-5 (Anx5) as the specific label.	Phosphatidylserines	30-32	annexin A5	Homo sapiens	204-208
25348269-5	2015	In addition, PS-exposing EVs were enumerated by electron microscopy (EM) after labeling with Anx5 gold nanoparticles and sedimentation on EM grids.	Phosphatidylserines	13-15	annexin A5	Homo sapiens	93-97
25743751-5	2015	Apoptosis, as the mechanism of cell death was investigated morphologically by acridine orange/ethidium bromide (AO/EtBr) double staining, cell surface expression assay of phosphatidyl serine by Annexin V/PI technique, as well as the formation of DNA ladder.	Phosphatidylserines	171-190	annexin A5	Homo sapiens	194-203
25459532-7	2015	O-Phospho-L-Serine (OPLS) which is the head-group moiety of phosphatidylserine, interacts with the lipid binding region of FVIII.	Phosphatidylserines	60-78	coagulation factor VIII	Homo sapiens	123-128
25597631-4	2015	Lipidomic analysis of annexin A2-deficient mouse cells indicates that this protein plays a role in recruiting phosphatidylserine and phosphatidylinositides to Atg16L-positive vesicles.	Phosphatidylserines	110-128	annexin A2	Mus musculus	22-32
25597631-4	2015	Lipidomic analysis of annexin A2-deficient mouse cells indicates that this protein plays a role in recruiting phosphatidylserine and phosphatidylinositides to Atg16L-positive vesicles.	Phosphatidylserines	110-128	autophagy related 16-like 1 (S. cerevisiae)	Mus musculus	159-165
25587983-7	2015	As sPLA2 can hydrolyze phosphatidylserine, a phospholipid frequently used to assess microparticles, and might even clear microparticles, we further considered the impact of relevant sPLA2 enzymes, sPLA2 group IIA, V and X, on microparticle quantification.	Phosphatidylserines	23-41	phospholipase A2 group IIA	Homo sapiens	3-8
25564762-5	2015	This motif also mediates phosphatidylserine-induced oligomerization of PSR-1, suggesting a mechanism by which PSR-1 activates phagocytosis.	Phosphatidylserines	25-43	Bifunctional arginine demethylase and lysyl-hydroxylase psr-1;JmjC domain-containing protein	Caenorhabditis elegans	71-76
25564762-5	2015	This motif also mediates phosphatidylserine-induced oligomerization of PSR-1, suggesting a mechanism by which PSR-1 activates phagocytosis.	Phosphatidylserines	25-43	Bifunctional arginine demethylase and lysyl-hydroxylase psr-1;JmjC domain-containing protein	Caenorhabditis elegans	110-115
25564762-6	2015	Mutations in the phosphatidylserine-binding motif, but not in its Fe(II) binding site critical for the JmjC activity, abolish PSR-1 phagocytic function.	Phosphatidylserines	17-35	Bifunctional arginine demethylase and lysyl-hydroxylase psr-1;JmjC domain-containing protein	Caenorhabditis elegans	126-131
26418250-9	2015	Furthermore, CDK4 inhibition blunted enhanced PS-exposure elicited by tBOOH treatment.	Phosphatidylserines	46-48	cyclin dependent kinase 4	Homo sapiens	13-17
26618532-5	2015	METHODS: Flow cytometry and photometry, respectively, were employed to estimate phosphatidylserine exposure at the cell surface from annexin-V-binding, cell volume from forward scatter, hemolysis from hemoglobin release, [Ca2+]i from Fluo3-fluorescence, and abundance of reactive oxygen species (ROS) from 2",7"-dichlorodihydrofluorescein diacetate (DCFDA) fluorescence.	Phosphatidylserines	80-98	annexin A5	Homo sapiens	133-142
25285849-4	2015	The oat beta-D-glucan caused a concentration-dependent increase of caspase-3/-7 activation and appearance of phosphatidylserine on the external surface of cellular membranes where it was bound to annexin V-FITC, demonstrating the induction of apoptosis.	Phosphatidylserines	109-127	annexin A5	Homo sapiens	196-205
25378585-2	2015	In Saccharomyces cerevisiae, five related gene products (Dnf1, Dnf2, Dnf3, Drs2, and Neo1) are implicated in flipping of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine.	Phosphatidylserines	147-165	aminophospholipid-translocating P4-type ATPase DNF1	Saccharomyces cerevisiae S288C	57-61
25378585-2	2015	In Saccharomyces cerevisiae, five related gene products (Dnf1, Dnf2, Dnf3, Drs2, and Neo1) are implicated in flipping of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine.	Phosphatidylserines	147-165	aminophospholipid-translocating P4-type ATPase DNF2	Saccharomyces cerevisiae S288C	63-67
25378585-2	2015	In Saccharomyces cerevisiae, five related gene products (Dnf1, Dnf2, Dnf3, Drs2, and Neo1) are implicated in flipping of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine.	Phosphatidylserines	147-165	aminophospholipid-translocating P4-type ATPase DNF3	Saccharomyces cerevisiae S288C	69-73
25378585-2	2015	In Saccharomyces cerevisiae, five related gene products (Dnf1, Dnf2, Dnf3, Drs2, and Neo1) are implicated in flipping of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine.	Phosphatidylserines	147-165	aminophospholipid-translocating P4-type ATPase DRS2	Saccharomyces cerevisiae S288C	75-79
25378585-2	2015	In Saccharomyces cerevisiae, five related gene products (Dnf1, Dnf2, Dnf3, Drs2, and Neo1) are implicated in flipping of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine.	Phosphatidylserines	147-165	putative aminophospholipid-translocating P4-type ATPase NEO1	Saccharomyces cerevisiae S288C	85-89
25955791-1	2015	In order to elucidate how phosphatidylserine (PS6) interacts with AQP5 in a cell membrane, we developed a hybrid steered molecular dynamics (hSMD) method that involved: (1) Simultaneously steering two centers of mass of two selected segments of the ligand, and (2) equilibrating the ligand-protein complex with and without biasing the system.	Phosphatidylserines	26-44	taste 2 receptor member 63 pseudogene	Homo sapiens	46-49
25955791-1	2015	In order to elucidate how phosphatidylserine (PS6) interacts with AQP5 in a cell membrane, we developed a hybrid steered molecular dynamics (hSMD) method that involved: (1) Simultaneously steering two centers of mass of two selected segments of the ligand, and (2) equilibrating the ligand-protein complex with and without biasing the system.	Phosphatidylserines	26-44	aquaporin 5	Homo sapiens	66-70
25243850-7	2015	As an example of the latter mechanism, phosphatidylserine (PS) is synthesized on a region of the ER (mitochondria-associated membranes, MAM) and decarboxylated to phosphatidylethanolamine in mitochondria.	Phosphatidylserines	39-57	sarcoglycan gamma	Homo sapiens	136-139
25135664-6	2014	Analysis of lipid distributions near alphaS monomers indicates that the transition to a semi-extended helix is facilitated by concentration of phosphatidyl-serine headgroups along the inner edge of the protein.	Phosphatidylserines	143-162	synuclein alpha	Homo sapiens	37-43
25255925-6	2014	RESULTS: Reelin interacted with the liposomes containing phosphatidylserine (PS) or phosphatidylcholine.	Phosphatidylserines	57-75	reelin	Mus musculus	9-15
25255925-6	2014	RESULTS: Reelin interacted with the liposomes containing phosphatidylserine (PS) or phosphatidylcholine.	Phosphatidylserines	77-79	reelin	Mus musculus	9-15
25315773-5	2014	We found that ATP11A and ATP11C have flippase activities toward phosphatidylserine and phosphatidylethanolamine but not PC or sphingomyelin.	Phosphatidylserines	64-82	ATPase phospholipid transporting 11A	Homo sapiens	14-20
25315773-5	2014	We found that ATP11A and ATP11C have flippase activities toward phosphatidylserine and phosphatidylethanolamine but not PC or sphingomyelin.	Phosphatidylserines	64-82	ATPase phospholipid transporting 11C	Homo sapiens	25-31
25418092-4	2014	Here, we performed a quantitative analysis of the binding of AnxA2 to solid supported membranes containing the annexin binding lipids phosphatidylinositol-4,5-bisphosphate and phosphatidylserine in different compositions.	Phosphatidylserines	176-194	annexin A2	Homo sapiens	61-66
25418092-9	2014	Together our results reveal for the first time, to our knowledge, that AnxA2 and its derivatives bind cooperatively to membranes containing cholesterol, phosphatidylserine, and/or phosphatidylinositol-4,5-bisphosphate, thus providing a mechanistic model for the lipid clustering activity of AnxA2.	Phosphatidylserines	153-171	annexin A2	Homo sapiens	71-76
24789271-11	2014	We showed that Hsp70 selectively interacted with negatively charged phospholipids, particularly phosphatidyl serine (PS), within liposomes, which was followed by insertion into the lipid bilayer, forming high-molecular weight oligomers.	Phosphatidylserines	96-115	heat shock protein family A (Hsp70) member 4	Homo sapiens	15-20
24789271-11	2014	We showed that Hsp70 selectively interacted with negatively charged phospholipids, particularly phosphatidyl serine (PS), within liposomes, which was followed by insertion into the lipid bilayer, forming high-molecular weight oligomers.	Phosphatidylserines	117-119	heat shock protein family A (Hsp70) member 4	Homo sapiens	15-20
25034781-2	2014	We show that mouse CD300b (CLM7/LMIR5), expressed on myeloid cells, recognizes outer membrane-exposed phosphatidylserine (PS) and does not, as previously reported, directly recognize TIM1 or TIM4.	Phosphatidylserines	102-120	CD300 molecule like family member B	Mus musculus	27-31
25034781-2	2014	We show that mouse CD300b (CLM7/LMIR5), expressed on myeloid cells, recognizes outer membrane-exposed phosphatidylserine (PS) and does not, as previously reported, directly recognize TIM1 or TIM4.	Phosphatidylserines	102-120	CD300 molecule like family member B	Mus musculus	32-37
25034781-2	2014	We show that mouse CD300b (CLM7/LMIR5), expressed on myeloid cells, recognizes outer membrane-exposed phosphatidylserine (PS) and does not, as previously reported, directly recognize TIM1 or TIM4.	Phosphatidylserines	122-124	CD300 molecule like family member B	Mus musculus	27-31
25034781-2	2014	We show that mouse CD300b (CLM7/LMIR5), expressed on myeloid cells, recognizes outer membrane-exposed phosphatidylserine (PS) and does not, as previously reported, directly recognize TIM1 or TIM4.	Phosphatidylserines	122-124	CD300 molecule like family member B	Mus musculus	32-37
25034781-6	2014	Collectively, our data show that CD300b recognizes PS as a ligand, and regulates the phagocytosis of apoptotic cells via the DAP12 signaling pathway.	Phosphatidylserines	51-53	TYRO protein tyrosine kinase binding protein	Mus musculus	125-130
25494419-2	2014	PMPs accelerate thrombin generation and thus clot formation at sites of injury by exposing the procoagulant membrane phospholipid phosphatidylserine (PS).	Phosphatidylserines	130-148	coagulation factor II, thrombin	Homo sapiens	16-24
24657793-2	2014	STUDY DESIGN: Cholera toxin B chain (CTB) and annexin V (AV) which respectively binds GM1 ganglioside and phosphatidylserine were used to isolate extracellular vesicles from plasma of PE patients and healthy pregnant women.	Phosphatidylserines	106-124	phosphate cytidylyltransferase 1B, choline	Homo sapiens	37-40
24657793-2	2014	STUDY DESIGN: Cholera toxin B chain (CTB) and annexin V (AV) which respectively binds GM1 ganglioside and phosphatidylserine were used to isolate extracellular vesicles from plasma of PE patients and healthy pregnant women.	Phosphatidylserines	106-124	annexin A5	Homo sapiens	46-55
24992464-2	2014	PS is synthesized from phosphatidylcholine or phosphatidylethanolamine by exchanging the base head group with serine, and this reaction is catalyzed by phosphatidylserine synthase 1 and phosphatidylserine synthase 2 located in the endoplasmic reticulum.	Phosphatidylserines	0-2	phosphatidylserine synthase 1	Homo sapiens	152-181
24992464-2	2014	PS is synthesized from phosphatidylcholine or phosphatidylethanolamine by exchanging the base head group with serine, and this reaction is catalyzed by phosphatidylserine synthase 1 and phosphatidylserine synthase 2 located in the endoplasmic reticulum.	Phosphatidylserines	0-2	phosphatidylserine synthase 2	Homo sapiens	186-215
24992464-3	2014	Activation of Akt, Raf-1 and protein kinase C signaling, which supports neuronal survival and differentiation, requires interaction of these proteins with PS localized in the cytoplasmic leaflet of the plasma membrane.	Phosphatidylserines	155-157	AKT serine/threonine kinase 1	Homo sapiens	14-17
24992464-3	2014	Activation of Akt, Raf-1 and protein kinase C signaling, which supports neuronal survival and differentiation, requires interaction of these proteins with PS localized in the cytoplasmic leaflet of the plasma membrane.	Phosphatidylserines	155-157	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	19-24
24920080-0	2014	Ca2+ switches the effect of PS-containing membranes on Factor Xa from activating to inhibiting: implications for initiation of blood coagulation.	Phosphatidylserines	28-30	coagulation factor X	Homo sapiens	55-64
25181299-6	2014	Finally, Atg8 homologs are conjugated to phospholipids, phosphatidylethanolamine, and phosphatidylserine.	Phosphatidylserines	86-104	GABA type A receptor associated protein like 2	Homo sapiens	9-13
24984896-3	2014	We previously showed that fluorescently labeled Annexin A5 (AnxA5), which binds specifically to phosphatidylserine (PS) on dead/dying cells, can be used in experimental stroke for monitoring cell death with optical imaging.	Phosphatidylserines	96-114	annexin A5	Mus musculus	48-58
24984896-3	2014	We previously showed that fluorescently labeled Annexin A5 (AnxA5), which binds specifically to phosphatidylserine (PS) on dead/dying cells, can be used in experimental stroke for monitoring cell death with optical imaging.	Phosphatidylserines	96-114	annexin A5	Mus musculus	60-65
24984896-6	2014	They were injected intravenously with either PS-binding AnxA5 or the nonfunctional AnxA5 (negative control), labeled with 99mTc and Alexa Fluor 568, respectively.	Phosphatidylserines	45-47	annexin A5	Mus musculus	56-61
25115379-2	2014	Internalization of CagA by human epithelial cells occurs by an unknown mechanism that requires interaction with the host membrane lipid phosphatidylserine.	Phosphatidylserines	136-154	S100 calcium binding protein A8	Homo sapiens	19-23
25115379-8	2014	CagA and F-BAR domains share binding specificity for phosphatidylserine and phosphoinositides.	Phosphatidylserines	53-71	S100 calcium binding protein A8	Homo sapiens	0-4
25000564-3	2014	Glycosaminoglycans and certain negatively charged phospholipids, like phosphatidylserine, bind to PCI and modulate its activity.	Phosphatidylserines	70-88	serpin family A member 5	Homo sapiens	98-101
24910243-6	2014	PLA2G2E altered minor lipoprotein phospholipids, phosphatidylserine and phosphatidylethanolamine, and moderately facilitated lipid accumulation in adipose tissue and liver.	Phosphatidylserines	49-67	phospholipase A2, group IIE	Mus musculus	0-7
24802409-6	2014	Overexpression of the wild-type hECT and hECT mutants containing amino acid substitutions in the HxGH motif in the C-terminal CT domain suppressed the growth defect of the Saccharomyces cerevisiae mutant of ECT1 encoding ECT in the absence of a PE supply via the decarboxylation of phosphatidylserine, but overexpression of hECT mutants of the N-terminal CT domain did not.	Phosphatidylserines	282-300	ECT	Homo sapiens	32-36
24802409-6	2014	Overexpression of the wild-type hECT and hECT mutants containing amino acid substitutions in the HxGH motif in the C-terminal CT domain suppressed the growth defect of the Saccharomyces cerevisiae mutant of ECT1 encoding ECT in the absence of a PE supply via the decarboxylation of phosphatidylserine, but overexpression of hECT mutants of the N-terminal CT domain did not.	Phosphatidylserines	282-300	ECT	Homo sapiens	41-45
24802409-6	2014	Overexpression of the wild-type hECT and hECT mutants containing amino acid substitutions in the HxGH motif in the C-terminal CT domain suppressed the growth defect of the Saccharomyces cerevisiae mutant of ECT1 encoding ECT in the absence of a PE supply via the decarboxylation of phosphatidylserine, but overexpression of hECT mutants of the N-terminal CT domain did not.	Phosphatidylserines	282-300	ethanolamine-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	207-211
24802409-6	2014	Overexpression of the wild-type hECT and hECT mutants containing amino acid substitutions in the HxGH motif in the C-terminal CT domain suppressed the growth defect of the Saccharomyces cerevisiae mutant of ECT1 encoding ECT in the absence of a PE supply via the decarboxylation of phosphatidylserine, but overexpression of hECT mutants of the N-terminal CT domain did not.	Phosphatidylserines	282-300	ECT	Homo sapiens	33-36
24802409-6	2014	Overexpression of the wild-type hECT and hECT mutants containing amino acid substitutions in the HxGH motif in the C-terminal CT domain suppressed the growth defect of the Saccharomyces cerevisiae mutant of ECT1 encoding ECT in the absence of a PE supply via the decarboxylation of phosphatidylserine, but overexpression of hECT mutants of the N-terminal CT domain did not.	Phosphatidylserines	282-300	ECT	Homo sapiens	41-45
24841277-0	2014	High-yield phosphatidylserine production via yeast surface display of phospholipase D from Streptomyces chromofuscus on Pichia pastoris.	Phosphatidylserines	11-29	phospholipase D	Saccharomyces cerevisiae S288C	70-85
24644264-7	2014	We also provide evidence that annexins mediate the binding of SerpinB2 to phosphatidylserine, a lipid characteristically exposed on the surface of MPs.	Phosphatidylserines	74-92	serine (or cysteine) peptidase inhibitor, clade B, member 2	Mus musculus	62-70
24762434-6	2014	Overproduction of E2 increased apoptosis-independent extrusion of PS on LCs, which in turn promoted engulfment by E2/ERalpha-activated macrophages that was mediated by AXL-GAS6-PS interaction.	Phosphatidylserines	66-68	estrogen receptor 1 (alpha)	Mus musculus	117-124
24762434-6	2014	Overproduction of E2 increased apoptosis-independent extrusion of PS on LCs, which in turn promoted engulfment by E2/ERalpha-activated macrophages that was mediated by AXL-GAS6-PS interaction.	Phosphatidylserines	66-68	AXL receptor tyrosine kinase	Mus musculus	168-171
24762434-6	2014	Overproduction of E2 increased apoptosis-independent extrusion of PS on LCs, which in turn promoted engulfment by E2/ERalpha-activated macrophages that was mediated by AXL-GAS6-PS interaction.	Phosphatidylserines	66-68	growth arrest specific 6	Mus musculus	172-176
24821794-6	2014	The dATP8B locus encodes a member of the P4-type ATPase family thought to flip aminophospholipids such as phosphatidylserine and phosphatidylethanolamine from one membrane leaflet to the other.	Phosphatidylserines	106-124	ATPase 8B	Drosophila melanogaster	4-10
24824606-6	2014	We identified eight different lipid classes that changed as a result of the GLTP down- or up-regulation treatments; glucosylceramide, lactosylceramide, globotriaosylceramide, ceramide, sphingomyelin, cholesterol-esters, diacylglycerol and phosphatidylserine.	Phosphatidylserines	239-257	glycolipid transfer protein	Homo sapiens	76-80
24824606-12	2014	For the glycerophospholipids, phosphatidylserine was the only species that was lower in GLTP overexpressing cells.	Phosphatidylserines	30-48	glycolipid transfer protein	Homo sapiens	88-92
24801051-12	2014	Tumor uptake of annexin A5-streptavidin was higher and persisted longer than annexin A5-uptake but depended less on phosphatidylserine binding.	Phosphatidylserines	116-134	annexin A5	Homo sapiens	16-26
24918058-3	2014	To understand the details of these interactions, a biophysical analysis of the binding of beta2GPI to LPS and phosphatidylserine (PS) was performed.	Phosphatidylserines	110-128	apolipoprotein H	Homo sapiens	90-98
24480410-5	2014	In the presence of cardiolipin (CL), bis-monoacylglycero phosphate (BMP), or phosphatidylserine (PS) Hsp70 attaches to membranes peripherally, without penetration.	Phosphatidylserines	77-95	heat shock protein family A (Hsp70) member 4	Homo sapiens	101-106
24488024-11	2014	Moreover, lipidomic analysis of ER phospholipids revealed increased palmitate incorporation into phosphatidylethanolamine and phosphatidylserine classes associated with the CPT1A KD.	Phosphatidylserines	126-144	carnitine palmitoyltransferase 1A	Homo sapiens	173-178
24688027-5	2014	Overexpression of uPAR in HEK-293 cells enhanced efferocytosis, which was inhibited by Annexin V and phosphatidylserine (PS) liposome, suggesting that uPAR-mediated efferocytosis is dependent on PS.	Phosphatidylserines	101-119	plasminogen activator, urokinase receptor	Homo sapiens	18-22
24688027-5	2014	Overexpression of uPAR in HEK-293 cells enhanced efferocytosis, which was inhibited by Annexin V and phosphatidylserine (PS) liposome, suggesting that uPAR-mediated efferocytosis is dependent on PS.	Phosphatidylserines	101-119	plasminogen activator, urokinase receptor	Homo sapiens	151-155
24688027-14	2014	HK plus PS liposome stimulated a complex formation of CrkII with p130Cas and Dock-180 and Rac1 activation in uPAR-293 cells, but not in control HEK-293 cells.	Phosphatidylserines	8-10	CRK proto-oncogene, adaptor protein	Homo sapiens	54-59
24688027-14	2014	HK plus PS liposome stimulated a complex formation of CrkII with p130Cas and Dock-180 and Rac1 activation in uPAR-293 cells, but not in control HEK-293 cells.	Phosphatidylserines	8-10	BCAR1 scaffold protein, Cas family member	Homo sapiens	65-72
24688027-14	2014	HK plus PS liposome stimulated a complex formation of CrkII with p130Cas and Dock-180 and Rac1 activation in uPAR-293 cells, but not in control HEK-293 cells.	Phosphatidylserines	8-10	dedicator of cytokinesis 1	Homo sapiens	77-85
24688027-14	2014	HK plus PS liposome stimulated a complex formation of CrkII with p130Cas and Dock-180 and Rac1 activation in uPAR-293 cells, but not in control HEK-293 cells.	Phosphatidylserines	8-10	Rac family small GTPase 1	Homo sapiens	90-94
24688027-14	2014	HK plus PS liposome stimulated a complex formation of CrkII with p130Cas and Dock-180 and Rac1 activation in uPAR-293 cells, but not in control HEK-293 cells.	Phosphatidylserines	8-10	plasminogen activator, urokinase receptor	Homo sapiens	109-113
24688027-15	2014	Thus, uPAR mediates efferocytosis through HK interaction with PS on apoptotic cells and activation of the Rac1 pathway.	Phosphatidylserines	62-64	plasminogen activator, urokinase receptor	Homo sapiens	6-10
24763383-1	2014	The C2 domain of PKCalpha (C2alpha) induces fluorescence self-quenching of NBD-PS in the presence of Ca2+, which is interpreted as the demixing of phosphatidylserine from a mixture of this phospholipid with phosphatidylcholine.	Phosphatidylserines	147-165	protein kinase C alpha	Homo sapiens	17-25
24763383-5	2014	The demixing induced by the C2alpha domain may have a physiological significance since it means that the binding of PKCalpha to membranes is accompanied by the formation of domains enriched in activating lipids, like phosphatidylserine and PIP2.	Phosphatidylserines	217-235	protein kinase C alpha	Homo sapiens	116-124
24706780-4	2014	Using a combination of interfacial X-ray scattering, molecular dynamics simulations, and membrane binding assays, we demonstrate how Tim4 recognizes PS in the context of a lipid bilayer.	Phosphatidylserines	149-151	T cell immunoglobulin and mucin domain containing 4	Homo sapiens	133-137
24706780-6	2014	This organization makes Tim4 sensitive to PS surface concentration in a manner capable of supporting differential recognition on the basis of PS exposure level.	Phosphatidylserines	42-44	T cell immunoglobulin and mucin domain containing 4	Homo sapiens	24-28
24706780-7	2014	The structurally homologous, but functionally distinct, Tim1 and Tim3 are significantly less sensitive to PS surface density, likely reflecting the differences in immunological function between the Tim proteins.	Phosphatidylserines	106-108	hepatitis A virus cellular receptor 1	Homo sapiens	56-60
24706780-7	2014	The structurally homologous, but functionally distinct, Tim1 and Tim3 are significantly less sensitive to PS surface density, likely reflecting the differences in immunological function between the Tim proteins.	Phosphatidylserines	106-108	hepatitis A virus cellular receptor 2	Homo sapiens	65-69
24706780-7	2014	The structurally homologous, but functionally distinct, Tim1 and Tim3 are significantly less sensitive to PS surface density, likely reflecting the differences in immunological function between the Tim proteins.	Phosphatidylserines	106-108	hepatitis A virus cellular receptor 1	Homo sapiens	56-59
25210648-3	2014	We sought to identify key differences in the presence of PS within Rab and Rab11-FIP containing membranes.	Phosphatidylserines	57-59	ArfGAP with FG repeats 1	Homo sapiens	67-70
25210648-3	2014	We sought to identify key differences in the presence of PS within Rab and Rab11-FIP containing membranes.	Phosphatidylserines	57-59	upstream transcription factor 2, c-fos interacting	Homo sapiens	81-84
25210648-8	2014	Live cell dual expression studies of Rab11-FIPs with LactC2 indicated that PS is enriched along tubular compartments of the Rab11a-dependent recycling system.	Phosphatidylserines	75-77	RAB11A, member RAS oncogene family	Homo sapiens	37-42
25210648-8	2014	Live cell dual expression studies of Rab11-FIPs with LactC2 indicated that PS is enriched along tubular compartments of the Rab11a-dependent recycling system.	Phosphatidylserines	75-77	RAB11A, member RAS oncogene family	Homo sapiens	124-130
25210648-11	2014	These results suggest distinct associations of Rab GTPases and Rab11-FIPs with PS-containing recycling system membrane domains.	Phosphatidylserines	79-81	ArfGAP with FG repeats 1	Homo sapiens	47-50
25210648-11	2014	These results suggest distinct associations of Rab GTPases and Rab11-FIPs with PS-containing recycling system membrane domains.	Phosphatidylserines	79-81	RAB11A, member RAS oncogene family	Homo sapiens	63-68
24467409-3	2014	To identify the structural basis of this allosteric regulation, we used FRET to monitor changes in FXa length in response to (i) soluble short-chain PS [C6PS (dicaproylphosphatidylserine)], (ii) PS membranes, and (iii) FVa in the presence of C6PS and membranes.	Phosphatidylserines	149-151	coagulation factor X	Homo sapiens	99-102
24467409-3	2014	To identify the structural basis of this allosteric regulation, we used FRET to monitor changes in FXa length in response to (i) soluble short-chain PS [C6PS (dicaproylphosphatidylserine)], (ii) PS membranes, and (iii) FVa in the presence of C6PS and membranes.	Phosphatidylserines	155-157	coagulation factor X	Homo sapiens	99-102
24467409-8	2014	However, when both FVa2 (a FVa glycoform) and either C6PS- or PS-containing membranes were bound to FXa, the overall change in length was comparable (~5.6-5.8 A), indicating that C6PS- and PS-containing membranes in conjunction with FVa2 have comparable regulatory effects on FXa.	Phosphatidylserines	55-57	coagulation factor X	Homo sapiens	100-103
24467409-8	2014	However, when both FVa2 (a FVa glycoform) and either C6PS- or PS-containing membranes were bound to FXa, the overall change in length was comparable (~5.6-5.8 A), indicating that C6PS- and PS-containing membranes in conjunction with FVa2 have comparable regulatory effects on FXa.	Phosphatidylserines	62-64	coagulation factor X	Homo sapiens	100-103
24578286-4	2014	Incorporation of (32) P into PS was significantly delayed in sac1  cells.	Phosphatidylserines	29-31	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	61-65
24578286-5	2014	Such a delay was also observed in SAC1- and PS decarboxylase gene-deleted cells, suggesting that the reduction in the PS level is caused by a reduction in the rate of biosynthesis of PS.	Phosphatidylserines	118-120	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	34-38
24578286-6	2014	A reduction in the PS level was also observed with repression of STT4 encoding phosphatidylinositol 4-kinase or deletion of VPS34 encoding phophatidylinositol 3-kinase.	Phosphatidylserines	19-21	1-phosphatidylinositol 4-kinase STT4	Saccharomyces cerevisiae S288C	65-69
24578286-6	2014	A reduction in the PS level was also observed with repression of STT4 encoding phosphatidylinositol 4-kinase or deletion of VPS34 encoding phophatidylinositol 3-kinase.	Phosphatidylserines	19-21	phosphatidylinositol 3-kinase VPS34	Saccharomyces cerevisiae S288C	124-129
24578286-8	2014	Finally, we observed an abnormal PS distribution in sac1  cells when a specific probe for PS was expressed.	Phosphatidylserines	33-35	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	52-56
24556712-7	2014	Intracellular mature virions (IMVs) of the IGFBP-3-expressing virus P13-SigE7Lamp-H5-IGFBP-3 have two structural differences: they incorporate the IGFBP-3 protein and they have elevated phosphatidylserine (PS) exposure on outer membrane that could result in increased uptake of IMVs by macropinocytosis.	Phosphatidylserines	186-204	insulin like growth factor binding protein 3	Homo sapiens	43-50
24333558-2	2014	The binding of MC540 with PC-based bilayers and copper ions with PS-based ones are the basis of their use as organic and inorganic probes to sense PS:PC ratio in silica supported mixed bilayers.	Phosphatidylserines	65-67	surfactant protein C	Homo sapiens	147-152
24334268-3	2014	In this work, PS was obtained by transphosphatidylation using phospholipase D (PLD) and PL self-assembled into liposomes as the substrates.	Phosphatidylserines	14-16	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	62-77
24334268-3	2014	In this work, PS was obtained by transphosphatidylation using phospholipase D (PLD) and PL self-assembled into liposomes as the substrates.	Phosphatidylserines	14-16	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	79-82
24334268-12	2014	On the whole, this work provided key parameters for the formulation of liposomes using enzymatic PLD technology, to produce lecithins enriched in different proportions of PS and esterified with various types of fatty acids depending on the initial lecithin source.	Phosphatidylserines	171-173	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	97-100
24413176-2	2014	In the retina, ATP8A2 is localized in photoreceptors where it uses ATP to transport phosphatidylserine (PS) and phosphatidylethanolamine (PE) from the exoplasmic to the cytoplasmic leaflet of membranes.	Phosphatidylserines	84-102	ATPase, aminophospholipid transporter-like, class I, type 8A, member 2	Mus musculus	15-21
24413176-2	2014	In the retina, ATP8A2 is localized in photoreceptors where it uses ATP to transport phosphatidylserine (PS) and phosphatidylethanolamine (PE) from the exoplasmic to the cytoplasmic leaflet of membranes.	Phosphatidylserines	104-106	ATPase, aminophospholipid transporter-like, class I, type 8A, member 2	Mus musculus	15-21
24366544-4	2014	Phosphatidylserine is a common constituent of all Ras nanoclusters but is only an obligate structural component of K-Ras nanoclusters.	Phosphatidylserines	0-18	KRAS proto-oncogene, GTPase	Homo sapiens	115-120
23820751-7	2014	Addition of CLM-1 ligand (e.g., phosphatidylserine) rendered wild-type eosinophils hypochemotactic in vitro and blockade of CLM-1/ligand interactions rendered wild-type eosinophils hyperchemotactic in vitro and in vivo in a model of allergic airway disease.	Phosphatidylserines	32-50	CD300 molecule like family member f	Homo sapiens	12-17
24333423-10	2014	Cholesterol had the opposite effect on the HAS2 activity in liposomes composed of phosphatidylethanolamine or phosphatidylserine.	Phosphatidylserines	110-128	hyaluronan synthase 2	Homo sapiens	43-47
24725086-0	2014	Phosphatidylserine and curcumin act synergistically to down-regulate release of interleukin-1beta from lipopolysaccharide-stimulated cortical primary microglial cells.	Phosphatidylserines	0-18	interleukin 1 beta	Rattus norvegicus	80-97
24725086-9	2014	PS and curcumin inhibited the release of interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha induced by lipopolysaccharide.	Phosphatidylserines	0-2	interleukin 1 beta	Rattus norvegicus	41-63
24725086-9	2014	PS and curcumin inhibited the release of interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha induced by lipopolysaccharide.	Phosphatidylserines	0-2	interleukin 6	Rattus norvegicus	65-102
24211866-5	2014	OLO-2-induced the externalization of phosphatidyl-serine (PS) and the loss of DeltaPsim are blocked by p38 inhibitor SB203580 or JNK inhibitor SP600125.	Phosphatidylserines	37-56	mitogen-activated protein kinase 14	Homo sapiens	103-106
24211866-5	2014	OLO-2-induced the externalization of phosphatidyl-serine (PS) and the loss of DeltaPsim are blocked by p38 inhibitor SB203580 or JNK inhibitor SP600125.	Phosphatidylserines	37-56	mitogen-activated protein kinase 8	Homo sapiens	129-132
24211866-5	2014	OLO-2-induced the externalization of phosphatidyl-serine (PS) and the loss of DeltaPsim are blocked by p38 inhibitor SB203580 or JNK inhibitor SP600125.	Phosphatidylserines	58-60	mitogen-activated protein kinase 14	Homo sapiens	103-106
24211866-5	2014	OLO-2-induced the externalization of phosphatidyl-serine (PS) and the loss of DeltaPsim are blocked by p38 inhibitor SB203580 or JNK inhibitor SP600125.	Phosphatidylserines	58-60	mitogen-activated protein kinase 8	Homo sapiens	129-132
24241535-3	2014	PSS1 is one of two enzymes involved in the production of phosphatidylserine.	Phosphatidylserines	57-75	phosphatidylserine synthase 1	Homo sapiens	0-4
24220029-5	2013	Depletion of sphingomyelin in stably transfected HEK293 cells expressing the Tangier disease W590S mutant ABCA1 isoform rescued the defect in PS exposure and restored cholesterol efflux to apoAI.	Phosphatidylserines	142-144	ATP binding cassette subfamily A member 1	Homo sapiens	106-111
24001019-3	2013	Employing lipid-binding assays and quartz crystal microbalance with dissipation we have determined that JP2 is selective for PS (phosphatidylserine), with a Kd value of ~0.5 muM, with the N-terminal domain mediating this interaction.	Phosphatidylserines	125-127	junctophilin 2	Homo sapiens	104-107
24001019-4	2013	JP2 also binds PtdIns(3,4,5)P3 at a different site than PS, resulting in the protein adopting a more flexible conformation; this interaction is modulated by both Ca(2+) and Mg(2+) ions.	Phosphatidylserines	56-58	junctophilin 2	Homo sapiens	0-3
24097981-6	2013	ABCA1 actively exported or flipped phosphatidylcholine, phosphatidylserine, and sphingomyelin from the cytoplasmic to the exocytoplasmic leaflet of membranes, whereas ABCA7 preferentially exported phosphatidylserine.	Phosphatidylserines	56-74	ATP binding cassette subfamily A member 1	Homo sapiens	0-5
23708817-1	2013	A novel electrochemiluminescence (ECL) cytosensors was developed for the detection of early apoptotic cells by the specific interaction between Annexin V and phosphatidylserine(PS) based on ECL signal of CdS-QDs.	Phosphatidylserines	158-176	annexin A5	Homo sapiens	144-153
24196413-6	2013	Most recently, Osh6p and Osh7p were demonstrated to show specific affinity for phosphatidylserine (PS), and to play a role in the intracellular transport of this glycerophospholipid; Additionally, two mammalian ORPs were shown to bind PS.	Phosphatidylserines	79-97	oxysterol-binding protein OSH6	Saccharomyces cerevisiae S288C	15-20
24196413-6	2013	Most recently, Osh6p and Osh7p were demonstrated to show specific affinity for phosphatidylserine (PS), and to play a role in the intracellular transport of this glycerophospholipid; Additionally, two mammalian ORPs were shown to bind PS.	Phosphatidylserines	79-97	oxysterol-binding protein related protein OSH7	Saccharomyces cerevisiae S288C	25-30
24196413-6	2013	Most recently, Osh6p and Osh7p were demonstrated to show specific affinity for phosphatidylserine (PS), and to play a role in the intracellular transport of this glycerophospholipid; Additionally, two mammalian ORPs were shown to bind PS.	Phosphatidylserines	99-101	oxysterol-binding protein OSH6	Saccharomyces cerevisiae S288C	15-20
24196413-6	2013	Most recently, Osh6p and Osh7p were demonstrated to show specific affinity for phosphatidylserine (PS), and to play a role in the intracellular transport of this glycerophospholipid; Additionally, two mammalian ORPs were shown to bind PS.	Phosphatidylserines	99-101	oxysterol-binding protein related protein OSH7	Saccharomyces cerevisiae S288C	25-30
24196413-6	2013	Most recently, Osh6p and Osh7p were demonstrated to show specific affinity for phosphatidylserine (PS), and to play a role in the intracellular transport of this glycerophospholipid; Additionally, two mammalian ORPs were shown to bind PS.	Phosphatidylserines	235-237	oxysterol-binding protein OSH6	Saccharomyces cerevisiae S288C	15-20
24196413-6	2013	Most recently, Osh6p and Osh7p were demonstrated to show specific affinity for phosphatidylserine (PS), and to play a role in the intracellular transport of this glycerophospholipid; Additionally, two mammalian ORPs were shown to bind PS.	Phosphatidylserines	235-237	oxysterol-binding protein related protein OSH7	Saccharomyces cerevisiae S288C	25-30
23954480-2	2013	The C2A domain of rat synaptotagmin I binds to phosphatidylserine (PS) exposed during cell death and modification to its lysine residues has been shown to disrupt PS binding.	Phosphatidylserines	47-65	synaptotagmin 1	Rattus norvegicus	22-37
23954480-2	2013	The C2A domain of rat synaptotagmin I binds to phosphatidylserine (PS) exposed during cell death and modification to its lysine residues has been shown to disrupt PS binding.	Phosphatidylserines	67-69	synaptotagmin 1	Rattus norvegicus	22-37
23954480-2	2013	The C2A domain of rat synaptotagmin I binds to phosphatidylserine (PS) exposed during cell death and modification to its lysine residues has been shown to disrupt PS binding.	Phosphatidylserines	163-165	synaptotagmin 1	Rattus norvegicus	22-37
24074703-3	2013	Our study aims to investigate the effects of daunorubicin (DNR) and L-asparaginase (L-ASP) on phosphatidylserine (PS) exposure and the procoagulant activity (PCA) of Jurkat/ALL cells.	Phosphatidylserines	94-112	asparaginase and isoaspartyl peptidase 1	Homo sapiens	68-82
24074703-3	2013	Our study aims to investigate the effects of daunorubicin (DNR) and L-asparaginase (L-ASP) on phosphatidylserine (PS) exposure and the procoagulant activity (PCA) of Jurkat/ALL cells.	Phosphatidylserines	94-112	asparaginase and isoaspartyl peptidase 1	Homo sapiens	84-89
24074703-3	2013	Our study aims to investigate the effects of daunorubicin (DNR) and L-asparaginase (L-ASP) on phosphatidylserine (PS) exposure and the procoagulant activity (PCA) of Jurkat/ALL cells.	Phosphatidylserines	114-116	asparaginase and isoaspartyl peptidase 1	Homo sapiens	68-82
24074703-3	2013	Our study aims to investigate the effects of daunorubicin (DNR) and L-asparaginase (L-ASP) on phosphatidylserine (PS) exposure and the procoagulant activity (PCA) of Jurkat/ALL cells.	Phosphatidylserines	114-116	asparaginase and isoaspartyl peptidase 1	Homo sapiens	84-89
24074703-13	2013	CONCLUSIONS: Our results indicate that DNR and L-ASP increased the PCA of Jurkat/ALL cells through PS exposure and played a critical role in inducing thrombosis in ALL patients.	Phosphatidylserines	99-101	asparaginase and isoaspartyl peptidase 1	Homo sapiens	47-52
23990473-7	2013	Annexin V-immunogold staining revealed that the calcium-binding lipid phosphatidylserine (PS) was exposed on the external surface of serum MVs.	Phosphatidylserines	70-88	annexin A5	Homo sapiens	0-9
23990473-7	2013	Annexin V-immunogold staining revealed that the calcium-binding lipid phosphatidylserine (PS) was exposed on the external surface of serum MVs.	Phosphatidylserines	90-92	annexin A5	Homo sapiens	0-9
24009077-12	2013	These findings suggest that the C1 domain spikes 2092-2093 and 2158-2159 together modulate FVIII membrane assembly by a subtle, PS-dependent mechanism.	Phosphatidylserines	128-130	coagulation factor VIII	Homo sapiens	91-96
24146988-2	2013	The enzyme contributing most to PE formation is the mitochondrial phosphatidylserine decarboxylase 1 (Psd1p) which catalyzes conversion of phosphatidylserine (PS) to PE.	Phosphatidylserines	66-84	phosphatidylserine decarboxylase 1	Saccharomyces cerevisiae S288C	102-107
24146988-2	2013	The enzyme contributing most to PE formation is the mitochondrial phosphatidylserine decarboxylase 1 (Psd1p) which catalyzes conversion of phosphatidylserine (PS) to PE.	Phosphatidylserines	159-161	phosphatidylserine decarboxylase 1	Saccharomyces cerevisiae S288C	102-107
24098554-7	2013	ChAc red cell samples clearly showed a reduced response in drug-induced endovesiculation, lysophosphatidic acid-induced phosphatidylserine exposure, and calcium uptake.	Phosphatidylserines	120-138	vacuolar protein sorting 13 homolog A	Homo sapiens	0-4
23539172-2	2013	The objective of this study was to examine whether microbubbles targeted to integrin alphavbeta3 could be produced by conjugating a PS-containing clinically available ultrasound contrast agent with lactadherin.	Phosphatidylserines	132-134	integrin subunit alpha V	Homo sapiens	76-96
23539172-2	2013	The objective of this study was to examine whether microbubbles targeted to integrin alphavbeta3 could be produced by conjugating a PS-containing clinically available ultrasound contrast agent with lactadherin.	Phosphatidylserines	132-134	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	198-209
23539172-10	2013	The parallel plate flow chamber study revealed that the number of PS-containing bubbles adherent to HUVEC was increased about five times by the intermediation of lactadherin (12.1 +- 6.0 to 58.7 +- 33.1 bubbles).	Phosphatidylserines	66-68	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	162-173
23897804-5	2013	Vitellogenin binds directly to phosphatidylcholine liposomes and with higher affinity to liposomes containing phosphatidylserine, a lipid of the inner leaflet of cell membranes that is exposed in damaged cells.	Phosphatidylserines	110-128	vitellogenin	Apis mellifera	0-12
23850486-2	2013	Here, we showed that liposomes consisting of phosphatidylserine and lysophosphatidylcholine, a lipolysis product of phosphatidylcholine by PLA2, were phagocytosed by microglia, but failed to induce secretion of PGE2.	Phosphatidylserines	45-63	phospholipase A2 group IB	Homo sapiens	139-143
23784547-6	2013	PAK was also required for the thrombin-mediated activation of the MEK/ERK pathway, Akt, calcium signaling, and phosphatidylserine (PS) exposure.	Phosphatidylserines	111-129	coagulation factor II, thrombin	Homo sapiens	30-38
23784547-6	2013	PAK was also required for the thrombin-mediated activation of the MEK/ERK pathway, Akt, calcium signaling, and phosphatidylserine (PS) exposure.	Phosphatidylserines	131-133	coagulation factor II, thrombin	Homo sapiens	30-38
23951277-2	2013	In this work we investigated the occurrence of PS mobilization in mouse eggs, which express flippase Atp8a1 and scramblases Plscr1 and 3, as determined by RT-PCR; these enzyme are responsible for PS distribution in cell membranes.	Phosphatidylserines	47-49	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	Mus musculus	101-136
23951277-2	2013	In this work we investigated the occurrence of PS mobilization in mouse eggs, which express flippase Atp8a1 and scramblases Plscr1 and 3, as determined by RT-PCR; these enzyme are responsible for PS distribution in cell membranes.	Phosphatidylserines	196-198	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	Mus musculus	101-136
24252308-4	2013	RESULTS: We demonstrate that myelin as well as phosphatidylserine (PS), a phospholipid found in myelin, reduce nitric oxide production by macrophages through activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta).	Phosphatidylserines	47-65	peroxisome proliferator activated receptor delta	Homo sapiens	172-225
24252308-4	2013	RESULTS: We demonstrate that myelin as well as phosphatidylserine (PS), a phospholipid found in myelin, reduce nitric oxide production by macrophages through activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta).	Phosphatidylserines	47-65	peroxisome proliferator activated receptor delta	Homo sapiens	227-235
24252308-4	2013	RESULTS: We demonstrate that myelin as well as phosphatidylserine (PS), a phospholipid found in myelin, reduce nitric oxide production by macrophages through activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta).	Phosphatidylserines	67-69	peroxisome proliferator activated receptor delta	Homo sapiens	172-225
24252308-4	2013	RESULTS: We demonstrate that myelin as well as phosphatidylserine (PS), a phospholipid found in myelin, reduce nitric oxide production by macrophages through activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta).	Phosphatidylserines	67-69	peroxisome proliferator activated receptor delta	Homo sapiens	227-235
24252308-9	2013	Moreover, our results suggest that myelin-derived PS mediates PPARbeta/delta activation in macrophages after myelin uptake.	Phosphatidylserines	50-52	peroxisome proliferator activated receptor delta	Homo sapiens	62-70
23640773-3	2013	Recently, it was discovered that phosphatidylserine (PS) is a ligand for CD300a and that the interaction between PS expressed on apoptotic cells and CD300a inhibits the uptake of apoptotic cells by phagocytic cells.	Phosphatidylserines	33-51	CD300a molecule	Homo sapiens	73-79
23640773-3	2013	Recently, it was discovered that phosphatidylserine (PS) is a ligand for CD300a and that the interaction between PS expressed on apoptotic cells and CD300a inhibits the uptake of apoptotic cells by phagocytic cells.	Phosphatidylserines	33-51	CD300a molecule	Homo sapiens	149-155
23640773-3	2013	Recently, it was discovered that phosphatidylserine (PS) is a ligand for CD300a and that the interaction between PS expressed on apoptotic cells and CD300a inhibits the uptake of apoptotic cells by phagocytic cells.	Phosphatidylserines	53-55	CD300a molecule	Homo sapiens	73-79
23640773-3	2013	Recently, it was discovered that phosphatidylserine (PS) is a ligand for CD300a and that the interaction between PS expressed on apoptotic cells and CD300a inhibits the uptake of apoptotic cells by phagocytic cells.	Phosphatidylserines	53-55	CD300a molecule	Homo sapiens	149-155
23640773-4	2013	Whether PS can inhibit NK-cell activity through CD300a is unknown.	Phosphatidylserines	8-10	CD300a molecule	Homo sapiens	48-54
23640773-6	2013	We further demonstrated that both CD300a and its highly homologous molecule CD300c bind to the tumor cells equally well and that they recognize PS and additional unknown ligand(s) expressed by tumor cells.	Phosphatidylserines	144-146	CD300a molecule	Homo sapiens	34-40
23640773-6	2013	We further demonstrated that both CD300a and its highly homologous molecule CD300c bind to the tumor cells equally well and that they recognize PS and additional unknown ligand(s) expressed by tumor cells.	Phosphatidylserines	144-146	CD300c molecule	Homo sapiens	76-82
23640773-8	2013	Collectively, we demonstrate a new tumor immune evasion mechanism that is mediated through the interaction between PS and CD300a and we suggest that CD300c, similarly to CD300a, also interacts with PS.	Phosphatidylserines	115-117	CD300a molecule	Homo sapiens	122-128
23640773-8	2013	Collectively, we demonstrate a new tumor immune evasion mechanism that is mediated through the interaction between PS and CD300a and we suggest that CD300c, similarly to CD300a, also interacts with PS.	Phosphatidylserines	198-200	CD300c molecule	Homo sapiens	149-155
23791636-13	2013	The use of PLA2 inhibitors demonstrated that PS is actively deacylated during iron-induced oxidative stress.	Phosphatidylserines	45-47	phospholipase A2 group VI	Homo sapiens	11-15
23715428-1	2013	The trimer of a bradykinin derivative displayed a more than five-fold increase in binding affinity for phosphatidylserine-enriched nanovesicles as compared to its monomeric precursor.	Phosphatidylserines	103-121	kininogen 1	Homo sapiens	16-26
23754750-4	2013	We identified phosphatidylserine (PS) as a ligand on apoptotic cells for the phagocytic receptor Six Microns Under (SIMU) and report that PS alone is not sufficient for engulfment.	Phosphatidylserines	14-32	Nimrod C4	Drosophila melanogaster	97-114
23754750-4	2013	We identified phosphatidylserine (PS) as a ligand on apoptotic cells for the phagocytic receptor Six Microns Under (SIMU) and report that PS alone is not sufficient for engulfment.	Phosphatidylserines	34-36	Nimrod C4	Drosophila melanogaster	97-114
23874734-9	2013	Phosphatidylinositol and phosphatidylserine concentrations were associated with fat content*DGAT1 genotype with a stronger association for the AA than the KK genotype.	Phosphatidylserines	25-43	diacylglycerol O-acyltransferase 1	Bos taurus	92-97
23515154-0	2013	Phosphatidylserine increases IKBKAP levels in a humanized knock-in IKBKAP mouse model.	Phosphatidylserines	0-18	elongator complex protein 1	Mus musculus	29-35
23515154-0	2013	Phosphatidylserine increases IKBKAP levels in a humanized knock-in IKBKAP mouse model.	Phosphatidylserines	0-18	elongator complex protein 1	Mus musculus	67-73
23515154-6	2013	The FD mice were supplemented with phosphatidylserine (PS), a safe food supplement that increases mRNA and protein levels of IKBKAP in cell lines generated from FD patients.	Phosphatidylserines	35-53	elongator complex protein 1	Mus musculus	125-131
23515154-6	2013	The FD mice were supplemented with phosphatidylserine (PS), a safe food supplement that increases mRNA and protein levels of IKBKAP in cell lines generated from FD patients.	Phosphatidylserines	55-57	elongator complex protein 1	Mus musculus	125-131
23515154-7	2013	Here we demonstrated that PS treatment increases IKBAKP mRNA and IKAP protein levels in various tissues of FD mice without affecting exon 20 inclusion levels.	Phosphatidylserines	26-28	elongator complex protein 1	Mus musculus	65-69
23874859-0	2013	Phosphatidylinositol 4,5-bisphosphate decreases the concentration of Ca2+, phosphatidylserine and diacylglycerol required for protein kinase C alpha to reach maximum activity.	Phosphatidylserines	75-93	protein kinase C alpha	Canis lupus familiaris	126-148
23640483-9	2013	Blockade of p38 mitogen-activated protein kinase activation inhibited HNE-induced phosphatidylserine exposure and increased TF activity.	Phosphatidylserines	82-100	mitogen-activated protein kinase 14	Homo sapiens	12-15
23800467-2	2013	In addition, phosphatidylserine (PS) exposure on the platelet surface accelerates thrombin formation by the coagulation pathway.	Phosphatidylserines	13-31	coagulation factor II, thrombin	Homo sapiens	82-90
23800467-6	2013	A new study shows that Na(+) entry, resulting from coactivation of the transient receptor potential (TRP) nonselective cation channels TRPC3 and TRPC6, followed by reverse-mode operation of Na(+)/Ca(2+) exchangers, is an important mechanism for the increase in cytosolic Ca(2+) that triggers PS exposure, particularly during combined thrombin and collagen stimulation.	Phosphatidylserines	292-294	transient receptor potential cation channel subfamily C member 3	Homo sapiens	135-140
23800467-6	2013	A new study shows that Na(+) entry, resulting from coactivation of the transient receptor potential (TRP) nonselective cation channels TRPC3 and TRPC6, followed by reverse-mode operation of Na(+)/Ca(2+) exchangers, is an important mechanism for the increase in cytosolic Ca(2+) that triggers PS exposure, particularly during combined thrombin and collagen stimulation.	Phosphatidylserines	292-294	transient receptor potential cation channel subfamily C member 6	Homo sapiens	145-150
23800467-6	2013	A new study shows that Na(+) entry, resulting from coactivation of the transient receptor potential (TRP) nonselective cation channels TRPC3 and TRPC6, followed by reverse-mode operation of Na(+)/Ca(2+) exchangers, is an important mechanism for the increase in cytosolic Ca(2+) that triggers PS exposure, particularly during combined thrombin and collagen stimulation.	Phosphatidylserines	292-294	coagulation factor II, thrombin	Homo sapiens	334-342
23434712-1	2013	Phosphatidylserine (PS) rich in polyunsaturated fatty acids of the n-3 series was obtained by enzymatic synthesis with phospholipase D (PLD) and a marine lipid extract as substrate.	Phosphatidylserines	0-18	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	119-134
23434712-1	2013	Phosphatidylserine (PS) rich in polyunsaturated fatty acids of the n-3 series was obtained by enzymatic synthesis with phospholipase D (PLD) and a marine lipid extract as substrate.	Phosphatidylserines	0-18	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	136-139
23434712-1	2013	Phosphatidylserine (PS) rich in polyunsaturated fatty acids of the n-3 series was obtained by enzymatic synthesis with phospholipase D (PLD) and a marine lipid extract as substrate.	Phosphatidylserines	20-22	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	119-134
23434712-1	2013	Phosphatidylserine (PS) rich in polyunsaturated fatty acids of the n-3 series was obtained by enzymatic synthesis with phospholipase D (PLD) and a marine lipid extract as substrate.	Phosphatidylserines	20-22	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	136-139
23809131-7	2013	A variety of experimental observations imply that decryption of leucocyte surface TF involves both a dithiol/disulfide switch and exposure of phosphatidylserine.	Phosphatidylserines	142-160	coagulation factor III, tissue factor	Homo sapiens	82-84
23700640-10	2004	PS is also accessible for annexin V binding in apoptosis and necrosis because of disruption of the plasma membrane.	Phosphatidylserines	0-2	annexin A5	Mus musculus	26-35
23700640-11	2004	Annexin V binds to PS with high affinity (dissociation constant = 7 nM).	Phosphatidylserines	19-21	annexin A5	Mus musculus	0-9
23532839-9	2013	When TMEM16F was deleted, these cells failed to expose PS in response to Ca(2+) ionophore, but PS exposure was elicited by Fas ligand treatment.	Phosphatidylserines	55-57	anoctamin 6	Homo sapiens	5-12
23532839-9	2013	When TMEM16F was deleted, these cells failed to expose PS in response to Ca(2+) ionophore, but PS exposure was elicited by Fas ligand treatment.	Phosphatidylserines	95-97	anoctamin 6	Homo sapiens	5-12
23439251-7	2013	Activation of the tyrosine kinase receptor MERTK, which is implicated in phagocytosis of phosphatidylserine-exposing substrates, is a common feature of Sertoli and retinal pigmented epithelial cell phagocytosis.	Phosphatidylserines	89-107	MER proto-oncogene, tyrosine kinase	Homo sapiens	43-48
23530199-3	2013	Using a lipidomic method, we show that thrombin, collagen, or ionophore-activated human platelets externalize two phosphatidylserines (PSs) and five phosphatidylethanolamines (PEs).	Phosphatidylserines	114-133	coagulation factor II, thrombin	Homo sapiens	39-47
23530199-3	2013	Using a lipidomic method, we show that thrombin, collagen, or ionophore-activated human platelets externalize two phosphatidylserines (PSs) and five phosphatidylethanolamines (PEs).	Phosphatidylserines	135-138	coagulation factor II, thrombin	Homo sapiens	39-47
23530199-4	2013	Four percent of the total cellular PE/PS pool (~300 ng/2 x 10(8) cells, thrombin), is externalized via calcium mobilization and protease-activated receptors-1 and -4, and 48% is contained in microparticles.	Phosphatidylserines	38-40	coagulation factor II, thrombin	Homo sapiens	72-80
23369752-6	2013	Unexpectedly, negatively-charged cytosol-facing lipids, i.e., phosphatidic acid and phosphatidylserine, also supported BODIPY-glycolipid uptake by GLTP at high surface pressure.	Phosphatidylserines	84-102	glycolipid transfer protein	Homo sapiens	147-151
23430221-2	2013	Some Cl(-) channel inhibitors (NPPB, DIDS, niflumic acid) were shown to affect phosphatidylserine (PS) scrambling and, thus, the life span of human red blood cells (hRBCs).	Phosphatidylserines	79-97	natriuretic peptide B	Homo sapiens	31-35
23827636-11	2013	Phospho-ERK was activated by 50 muM PS at 30 min and 1h in growth medium.	Phosphatidylserines	36-38	mitogen-activated protein kinase 1	Homo sapiens	8-11
23827636-12	2013	In osteogenic medium, 50 muM PS extended phospho-ERK activation by osteogenic induction medium from 30 min to 8 h. U0126, an ERK inhibitor, suppressed the ALP expression induced by PS.	Phosphatidylserines	29-31	mitogen-activated protein kinase 1	Homo sapiens	49-52
23827636-12	2013	In osteogenic medium, 50 muM PS extended phospho-ERK activation by osteogenic induction medium from 30 min to 8 h. U0126, an ERK inhibitor, suppressed the ALP expression induced by PS.	Phosphatidylserines	29-31	mitogen-activated protein kinase 1	Homo sapiens	125-128
23827636-12	2013	In osteogenic medium, 50 muM PS extended phospho-ERK activation by osteogenic induction medium from 30 min to 8 h. U0126, an ERK inhibitor, suppressed the ALP expression induced by PS.	Phosphatidylserines	29-31	alkaline phosphatase, placental	Homo sapiens	155-158
23585650-5	2013	Lipid profiling revealed that 34C species of phosphatidylglycerol (PG) and monogalactosyl diacylglycerol (MGDG) content in ads2 mutants were lower and phosphatidic acid, phosphatidylinositol, phosphatidylethanolamine, phosphatidylcholine, lyso-phosphatidylcholine, and phosphatidylserine were higher than the wild type.	Phosphatidylserines	269-287	16:0delta9 desaturase 2	Arabidopsis thaliana	123-127
27430005-4	2013	The exposed phosphatidyl serine is detected by Annexin V, and propidium iodide stains the necrotic cells, which have leaky DNA content that help to differentiate the apoptotic and necrotic cells.	Phosphatidylserines	12-31	annexin A5	Homo sapiens	47-56
23416077-4	2013	Stabilin-2-mediated necrotic cell engulfment occurred in a PS-dependent manner.	Phosphatidylserines	59-61	stabilin 2	Homo sapiens	0-10
23303820-2	2013	The role of TMEM16F in apoptosis- or agonist-induced phosphatidylserine (PS) exposure was studied in platelets from a Scott syndrome patient and control subjects.	Phosphatidylserines	53-71	anoctamin 6	Homo sapiens	12-19
23303820-2	2013	The role of TMEM16F in apoptosis- or agonist-induced phosphatidylserine (PS) exposure was studied in platelets from a Scott syndrome patient and control subjects.	Phosphatidylserines	73-75	anoctamin 6	Homo sapiens	12-19
23303820-5	2013	On the other hand, high PS exposure induced by the Ca(2+)-mobilizing agonists convulxin/thrombin fully relied on mitochondrial depolarization and was virtually absent in Scott platelets.	Phosphatidylserines	24-26	coagulation factor II, thrombin	Homo sapiens	88-96
23303820-6	2013	Finally, PS exposure induced by collagen/thrombin was partly affected in Scott platelets, and the residual PS positive fraction was insensitive to inhibition of caspases or mitochondrial depolarization.	Phosphatidylserines	9-11	coagulation factor II, thrombin	Homo sapiens	41-49
23303820-7	2013	In conclusion, TMEM16F is not required for, but enhances, caspase-dependent PS exposure; convulxin-/thrombin-induced PS exposure is entirely dependent on TMEM16F, whereas collagen/thrombin-induced PS exposure results from 2 distinct pathways, one of which involves mitochondrial depolarization and is mediated by TMEM16F.	Phosphatidylserines	76-78	anoctamin 6	Homo sapiens	15-22
23303820-7	2013	In conclusion, TMEM16F is not required for, but enhances, caspase-dependent PS exposure; convulxin-/thrombin-induced PS exposure is entirely dependent on TMEM16F, whereas collagen/thrombin-induced PS exposure results from 2 distinct pathways, one of which involves mitochondrial depolarization and is mediated by TMEM16F.	Phosphatidylserines	76-78	coagulation factor II, thrombin	Homo sapiens	100-108
23216570-2	2013	Eryptotic erythrocytes may adhere to the vascular wall by binding of phosphatidylserine to endothelial CXC chemokine ligand 16 (CXCL16).	Phosphatidylserines	69-87	chemokine (C-X-C motif) ligand 16	Mus musculus	103-126
23216570-2	2013	Eryptotic erythrocytes may adhere to the vascular wall by binding of phosphatidylserine to endothelial CXC chemokine ligand 16 (CXCL16).	Phosphatidylserines	69-87	chemokine (C-X-C motif) ligand 16	Mus musculus	128-134
23329178-7	2013	Externalization of phosphatidyl serine and nuclear condensation occurred 30 min-2 h after the initiation of cell blebbing.	Phosphatidylserines	19-38	CD59 molecule (CD59 blood group)	Homo sapiens	76-81
23262193-0	2013	NMR solution structure of C2 domain of MFG-E8 and insights into its molecular recognition with phosphatidylserine.	Phosphatidylserines	95-113	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	39-45
23262193-2	2013	MFG-E8 binds to phosphatidylserine (PS) in membranes with high affinity.	Phosphatidylserines	16-34	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	0-6
23262193-2	2013	MFG-E8 binds to phosphatidylserine (PS) in membranes with high affinity.	Phosphatidylserines	36-38	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	0-6
23507231-0	2013	Phosphatidylserine inhibits inflammatory responses in interleukin-1beta-stimulated fibroblast-like synoviocytes and alleviates carrageenan-induced arthritis in rat.	Phosphatidylserines	0-18	interleukin 1 beta	Rattus norvegicus	54-71
23507231-7	2013	Phosphatidylserine inhibited the production of inflammatory mediators IL-6; IL-8; vascular endothelial growth factor; and, in particular, prostaglandin E(2) in IL-1beta-stimulated RA-FLS.	Phosphatidylserines	0-18	interleukin 6	Rattus norvegicus	70-74
23507231-7	2013	Phosphatidylserine inhibited the production of inflammatory mediators IL-6; IL-8; vascular endothelial growth factor; and, in particular, prostaglandin E(2) in IL-1beta-stimulated RA-FLS.	Phosphatidylserines	0-18	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
23507231-7	2013	Phosphatidylserine inhibited the production of inflammatory mediators IL-6; IL-8; vascular endothelial growth factor; and, in particular, prostaglandin E(2) in IL-1beta-stimulated RA-FLS.	Phosphatidylserines	0-18	vascular endothelial growth factor A	Homo sapiens	82-116
23426682-4	2013	We found that altering the function of the phospholipid scramblase-1 (PLSCR-1) by expressing a PLSCR-1 calcium-insensitive mutant or by using chromaffin cells from PLSCR-1-/- mice prevents outward translocation of PS in cells stimulated for exocytosis.	Phosphatidylserines	214-216	phospholipid scramblase 1	Mus musculus	43-68
23426682-4	2013	We found that altering the function of the phospholipid scramblase-1 (PLSCR-1) by expressing a PLSCR-1 calcium-insensitive mutant or by using chromaffin cells from PLSCR-1-/- mice prevents outward translocation of PS in cells stimulated for exocytosis.	Phosphatidylserines	214-216	phospholipid scramblase 1	Mus musculus	70-77
23244622-6	2013	However, a minimal level of TSC2 activity is necessary to modulate WISP1 cytoprotection that may require modulation of mTOR activity, since gene knockdown of TSC2 impairs the ability of WISP1 to protect microglia against apoptotic membrane phosphatidylserine (PS) exposure, nuclear DNA degradation, mitochondrial membrane depolarization, and cytochrome c release during Abeta.	Phosphatidylserines	240-258	TSC complex subunit 2	Homo sapiens	28-32
23244622-6	2013	However, a minimal level of TSC2 activity is necessary to modulate WISP1 cytoprotection that may require modulation of mTOR activity, since gene knockdown of TSC2 impairs the ability of WISP1 to protect microglia against apoptotic membrane phosphatidylserine (PS) exposure, nuclear DNA degradation, mitochondrial membrane depolarization, and cytochrome c release during Abeta.	Phosphatidylserines	240-258	cellular communication network factor 4	Homo sapiens	186-191
23250744-13	2013	We propose the following model based on these results; Tat2p is not ubiquitinated when the NH(2)-terminal region is bound to membrane phospholipids, but if it dissociates from the membrane due to a low level of phosphatidylserine caused by perturbation of phospholipid asymmetry in the lem3Delta mutant, Tat2p is ubiquitinated and then transported from the TGN to the vacuole.	Phosphatidylserines	211-229	aromatic amino acid transmembrane transporter TAT2	Saccharomyces cerevisiae S288C	55-60
22936354-10	2013	Our study is the first to our knowledge to reveal the requirement of Ano6 in PS scrambling in osteoblasts, supporting a function of PS exposure in the deposition of hydroxyapatite.	Phosphatidylserines	77-79	anoctamin 6	Mus musculus	69-73
23193974-7	2013	Furthermore, the phospholipid composition markedly influences P450 turnover and b(5) stimulation and specificity, particularly for CYP17A1, in the following order: phosphatidylserine &gt; phosphatidylethanolamine &gt; phosphatidylcholine.	Phosphatidylserines	164-182	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	131-138
23214401-1	2013	A soluble, short chain phosphatidylserine, 1,2-dicaproyl-sn-glycero-3-phospho-l-serine (C6PS), binds to discrete sites on FXa, FVa, and prothrombin to alter their conformations, to promote FXa dimerization (K(d) ~ 14 nM), and to enhance both the catalytic activity of FXa and the cofactor activity of FVa.	Phosphatidylserines	23-41	coagulation factor X	Homo sapiens	122-125
23214401-1	2013	A soluble, short chain phosphatidylserine, 1,2-dicaproyl-sn-glycero-3-phospho-l-serine (C6PS), binds to discrete sites on FXa, FVa, and prothrombin to alter their conformations, to promote FXa dimerization (K(d) ~ 14 nM), and to enhance both the catalytic activity of FXa and the cofactor activity of FVa.	Phosphatidylserines	23-41	coagulation factor X	Homo sapiens	189-192
23214401-1	2013	A soluble, short chain phosphatidylserine, 1,2-dicaproyl-sn-glycero-3-phospho-l-serine (C6PS), binds to discrete sites on FXa, FVa, and prothrombin to alter their conformations, to promote FXa dimerization (K(d) ~ 14 nM), and to enhance both the catalytic activity of FXa and the cofactor activity of FVa.	Phosphatidylserines	23-41	coagulation factor X	Homo sapiens	189-192
22858544-1	2013	Phosphatidylserine (PS) exposure on the external leaflet of the plasma membrane is widely observed during apoptosis and forms the basis for the annexin V binding assay to detect apoptotic cell death.	Phosphatidylserines	0-18	annexin A5	Homo sapiens	144-153
22858544-1	2013	Phosphatidylserine (PS) exposure on the external leaflet of the plasma membrane is widely observed during apoptosis and forms the basis for the annexin V binding assay to detect apoptotic cell death.	Phosphatidylserines	20-22	annexin A5	Homo sapiens	144-153
22669602-2	2013	Since mitochondria are key regulators in cell death pathways, we developed a simultaneous 3-parameter flow cytometric analysis that incorporates the change in mitochondrial membrane potential (Deltapsi(m)) in an Annexin-V [for phosphatidyl-serine (PS)] and propidium iodide (PI) assay system (3 parameters with 4 colours), and evaluated the apoptotic process using various haematological malignant cell lines and death triggers.	Phosphatidylserines	227-246	annexin A5	Homo sapiens	212-221
22669602-2	2013	Since mitochondria are key regulators in cell death pathways, we developed a simultaneous 3-parameter flow cytometric analysis that incorporates the change in mitochondrial membrane potential (Deltapsi(m)) in an Annexin-V [for phosphatidyl-serine (PS)] and propidium iodide (PI) assay system (3 parameters with 4 colours), and evaluated the apoptotic process using various haematological malignant cell lines and death triggers.	Phosphatidylserines	248-250	annexin A5	Homo sapiens	212-221
23071296-0	2013	Phosphatidylserine synthase 2: high efficiency for synthesizing phosphatidylserine containing docosahexaenoic acid.	Phosphatidylserines	64-82	phosphatidylserine synthase 2	Homo sapiens	0-29
23071296-1	2013	Phosphatidylserine (PS), the major anionic phospholipid in eukaryotic cell membranes, is synthesized by the integral membrane enzymes PS synthase 1 (PSS1) and 2 (PSS2).	Phosphatidylserines	0-18	phosphatidylserine synthase 1	Homo sapiens	149-153
23071296-1	2013	Phosphatidylserine (PS), the major anionic phospholipid in eukaryotic cell membranes, is synthesized by the integral membrane enzymes PS synthase 1 (PSS1) and 2 (PSS2).	Phosphatidylserines	0-18	phosphatidylserine synthase 2	Homo sapiens	162-166
23071296-1	2013	Phosphatidylserine (PS), the major anionic phospholipid in eukaryotic cell membranes, is synthesized by the integral membrane enzymes PS synthase 1 (PSS1) and 2 (PSS2).	Phosphatidylserines	20-22	phosphatidylserine synthase 1	Homo sapiens	149-153
23071296-1	2013	Phosphatidylserine (PS), the major anionic phospholipid in eukaryotic cell membranes, is synthesized by the integral membrane enzymes PS synthase 1 (PSS1) and 2 (PSS2).	Phosphatidylserines	20-22	phosphatidylserine synthase 2	Homo sapiens	162-166
23071296-3	2013	The purpose of this work was to characterize the hydrocarbon-chain preference of PSS2 to gain insight on the specialized role of PSS2 in PS accumulation in the DHA-abundant tissues.	Phosphatidylserines	81-83	phosphatidylserine synthase 2	Homo sapiens	129-133
23071296-8	2013	Preferential production of DHA-containing PS (DHA-PS) was consistently observed with PSS2 purified from a variety of cell lines as well as with microsomes from mutant cells in which PS synthesis relies primarily on PSS2.	Phosphatidylserines	42-44	phosphatidylserine synthase 2	Homo sapiens	85-89
23071296-8	2013	Preferential production of DHA-containing PS (DHA-PS) was consistently observed with PSS2 purified from a variety of cell lines as well as with microsomes from mutant cells in which PS synthesis relies primarily on PSS2.	Phosphatidylserines	42-44	phosphatidylserine synthase 2	Homo sapiens	215-219
23071296-8	2013	Preferential production of DHA-containing PS (DHA-PS) was consistently observed with PSS2 purified from a variety of cell lines as well as with microsomes from mutant cells in which PS synthesis relies primarily on PSS2.	Phosphatidylserines	50-52	phosphatidylserine synthase 2	Homo sapiens	85-89
23071296-8	2013	Preferential production of DHA-containing PS (DHA-PS) was consistently observed with PSS2 purified from a variety of cell lines as well as with microsomes from mutant cells in which PS synthesis relies primarily on PSS2.	Phosphatidylserines	50-52	phosphatidylserine synthase 2	Homo sapiens	215-219
23140172-5	2013	RESULTS:  P2Y(12) activation attenuated apoptosis induced by ABT-737 in human and mouse platelets in vitro, evidenced by reduced phosphatidylserine (PS) exposure, diminished depolarization of mitochondrial inner transmembrane potential (DeltaPsim) and decreased caspase-3 activation.	Phosphatidylserines	129-147	purinergic receptor P2Y, G-protein coupled 12	Mus musculus	10-17
24556698-11	2013	The effect of 2 mM phosphate on phosphatidylserine exposure was significantly augmented by increase of extracellular Ca(2+) to 1.7 mM, and significantly blunted by nominal absence of extracellular Ca(2+), by additional presence of pyrophosphate as well as by presence of p38 inhibitor SB203580.	Phosphatidylserines	32-50	mitogen-activated protein kinase 14	Homo sapiens	271-274
22526829-9	2013	PS exposure on CD14(+) cell surface was analyzed by flow cytometry.	Phosphatidylserines	0-2	CD14 molecule	Homo sapiens	15-19
23340420-4	2013	We show further that phosphatidylserine, a phospholipid recently found to be crucial for cell polarity, is enriched in Cdc42 microdomains.	Phosphatidylserines	21-39	cell division cycle 42	Homo sapiens	119-124
23340420-5	2013	Weakening a potential interaction between phosphatidylserine and Cdc42 enhances Cdc42 diffusion in the microdomains but impedes the strength of polarization.	Phosphatidylserines	42-60	cell division cycle 42	Homo sapiens	65-70
23340420-5	2013	Weakening a potential interaction between phosphatidylserine and Cdc42 enhances Cdc42 diffusion in the microdomains but impedes the strength of polarization.	Phosphatidylserines	42-60	cell division cycle 42	Homo sapiens	80-85
23175755-5	2013	Through forward and reverse genetics it was shown that AtADS2 is involved in the synthesis of the 24:1(n-9) and 26:1(n-9) components (X:Y, where X is chain length and Y is number of double bonds) of seed lipids, sphingolipids, and the membrane phospholipids phosphatidylserine, and phosphatidylethanolamine.	Phosphatidylserines	258-276	16:0delta9 desaturase 2	Arabidopsis thaliana	55-61
23533665-5	2013	Further analyses showed that PS-conjugated antigens were preferentially and efficiently captured by professional APCs, in particular, by CD11c(+)CD11b(+)MHCII(+) conventional dendritic cells (cDCs) compared to multilamellar liposome-conjugates or unconjugated antigens.	Phosphatidylserines	29-31	integrin subunit alpha X	Homo sapiens	137-142
23533665-5	2013	Further analyses showed that PS-conjugated antigens were preferentially and efficiently captured by professional APCs, in particular, by CD11c(+)CD11b(+)MHCII(+) conventional dendritic cells (cDCs) compared to multilamellar liposome-conjugates or unconjugated antigens.	Phosphatidylserines	29-31	integrin subunit alpha M	Homo sapiens	145-150
23437197-1	2013	Annexin 7 deficiency has previously been shown to foster suicidal death of erythrocytes or eryptosis, which is triggered by increase of intracellular Ca(2+) concentration ([Ca(2+)](i)) and characterized by cell shrinkage and cell membrane scrambling with subsequent phosphatidylserine exposure at the cell surface.	Phosphatidylserines	266-284	annexin A7	Mus musculus	0-9
23383331-5	2013	FK633, an alpha(IIb)beta3 antagonist, and cytochalasin B impaired platelet binding to the fibrin scaffold and significantly reduced PS exposure evoked by thrombin.	Phosphatidylserines	132-134	coagulation factor II, thrombin	Homo sapiens	154-162
23124206-7	2012	Here, using fluorescent PS as a substrate in an in vitro assay for Psd1p-dependent PE production in isolated mitochondria, we show that PS is transferred from the mitochondrial outer membrane to the inner membrane independently of Psd1p, Ups1p, and Ups2p and decarboxylated to PE by Psd1p in the inner membrane.	Phosphatidylserines	136-138	phosphatidylserine decarboxylase 1	Saccharomyces cerevisiae S288C	67-72
23124206-7	2012	Here, using fluorescent PS as a substrate in an in vitro assay for Psd1p-dependent PE production in isolated mitochondria, we show that PS is transferred from the mitochondrial outer membrane to the inner membrane independently of Psd1p, Ups1p, and Ups2p and decarboxylated to PE by Psd1p in the inner membrane.	Phosphatidylserines	136-138	Ups1p	Saccharomyces cerevisiae S288C	238-243
23124206-7	2012	Here, using fluorescent PS as a substrate in an in vitro assay for Psd1p-dependent PE production in isolated mitochondria, we show that PS is transferred from the mitochondrial outer membrane to the inner membrane independently of Psd1p, Ups1p, and Ups2p and decarboxylated to PE by Psd1p in the inner membrane.	Phosphatidylserines	136-138	Ups2p	Saccharomyces cerevisiae S288C	249-254
23166358-3	2012	Phosphatidylserine (PS) is the most abundant negatively charged lipid on the inner leaflet of the PM and makes a major contribution to membrane binding by the CD3epsilon cytoplasmic domain.	Phosphatidylserines	0-18	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	159-169
23166358-3	2012	Phosphatidylserine (PS) is the most abundant negatively charged lipid on the inner leaflet of the PM and makes a major contribution to membrane binding by the CD3epsilon cytoplasmic domain.	Phosphatidylserines	20-22	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	159-169
23148485-2	2012	The ability of Lp-PLA(2) to hydrolyze peroxidized species of phosphatidylserine (PS), acting as a recognition signal for clearance of apoptotic cells by professional phagocytes, as well as the products of the reaction has not been investigated.	Phosphatidylserines	61-79	phospholipase A2 group VII	Homo sapiens	15-23
23148485-3	2012	We performed liquid chromatography-electrospray ionization mass spectrometry-based structural characterization of oxygenated, hydrolyzed molecular species of PS-containing linoleic acid in either the sn-2 position (C(18:0)/C(18:2)) or in both sn-1 and sn-2 positions (C(18:2)/C(18:2)), formed in the cytochrome c- and H(2)O(2)-driven enzymatic oxidation reaction.	Phosphatidylserines	158-160	cytochrome c, somatic	Homo sapiens	300-312
23148485-5	2012	We found that Lp-PLA(2) catalyzed the hydrolysis of both nontruncated and truncated (oxidatively fragmented) species of oxidized PS species, albeit with different efficiencies, and performed detailed characterization of the major reaction products: oxygenated derivatives of linoleic acid as well as nonoxygenated and oxygenated species of lyso-PS.	Phosphatidylserines	129-131	phospholipase A2 group VII	Homo sapiens	14-23
23087357-3	2012	In the absence of the mPTP regulator cyclophilin D, agonist-initiated mPTP formation and high-level PS exposure were markedly blunted, but cytoplasmic calcium transients were unchanged.	Phosphatidylserines	100-102	peptidylprolyl isomerase D	Homo sapiens	37-50
23073177-7	2012	PTEN"s C2 domain binds phosphatidylserine (PS) tightly through its CBR3 loop, and its phosphatase domain also forms electrostatic interactions with PS.	Phosphatidylserines	43-45	phosphatase and tensin homolog	Homo sapiens	0-4
23073177-7	2012	PTEN"s C2 domain binds phosphatidylserine (PS) tightly through its CBR3 loop, and its phosphatase domain also forms electrostatic interactions with PS.	Phosphatidylserines	43-45	carbonyl reductase 3	Homo sapiens	67-71
23007400-6	2012	Our studies indicate that IPLA-1 binds directly to multiple acidic phospholipids, including phosphatidylserine, phosphatidylglycerol, cardiolipin, phosphatidic acid, and phosphorylated derivatives of phosphatidylinositol.	Phosphatidylserines	92-110	Intracellular phospholipase A1	Caenorhabditis elegans	26-32
22954799-2	2012	Eryptotic erythrocytes adhere to the vascular wall by binding of phosphatidylserine to the CXC chemokine ligand 16 (CXCL16).	Phosphatidylserines	65-83	C-X-C motif chemokine ligand 16	Homo sapiens	91-114
22954799-2	2012	Eryptotic erythrocytes adhere to the vascular wall by binding of phosphatidylserine to the CXC chemokine ligand 16 (CXCL16).	Phosphatidylserines	65-83	C-X-C motif chemokine ligand 16	Homo sapiens	116-122
22837472-7	2012	Formation of low-calcium PS-positive platelets was promoted by platelet concentration increase or shaking and was decreased by integrin alpha(IIb)beta(3) antagonists, platelet dilution, or in platelets from kindlin-3-deficient and Glanzmann thrombasthenia patients.	Phosphatidylserines	25-27	FERM domain containing kindlin 3	Homo sapiens	207-216
22669259-3	2012	Here, we demonstrate that the potent suppressing effect of clinically used alpha(IIb)beta(3) blockers on tissue factor-induced thrombin generation is linked to diminished platelet Ca(2+) responses and phosphatidylserine (PS) exposure.	Phosphatidylserines	201-219	coagulation factor II, thrombin	Homo sapiens	127-135
22669259-7	2012	Furthermore, the contribution of alpha(IIb)beta(3) to tissue factor-induced platelet Ca(2+) rises, PS exposure and thrombin generation in plasma are fully dependent on Syk kinase activity.	Phosphatidylserines	99-101	spleen associated tyrosine kinase	Homo sapiens	168-171
23035304-1	2004	Radiolabeled proteins, such as (99m)Tc- or (123)I-labeled annexin V and its derivatives that have a high affinity for externalized anionic phospholipids (e.g., phosphatidylserine (PS)) on apoptotic cells, were shown to be suitable for monitoring the efficacy and response to anticancer treatments with noninvasive imaging techniques such as single-photon emission tomography (2).	Phosphatidylserines	160-178	annexin A5	Homo sapiens	58-67
22160264-7	2012	Blocking of PS with 128 nmol/L annexin V reduced approximately 70% CPA of HUVECs and endothelial MPs, but human anti-tissue factor antibody had little inhibitive effect.	Phosphatidylserines	12-14	annexin A5	Homo sapiens	31-40
22521809-4	2012	Here, we studied the structure and dynamics of the three-repeat domain of tau (i.e. K19) when bound to membranes consisting of a phosphatidylcholine and phosphatidylserine mixture or phosphatidylserine alone.	Phosphatidylserines	153-171	microtubule associated protein tau	Homo sapiens	74-77
22521809-4	2012	Here, we studied the structure and dynamics of the three-repeat domain of tau (i.e. K19) when bound to membranes consisting of a phosphatidylcholine and phosphatidylserine mixture or phosphatidylserine alone.	Phosphatidylserines	153-171	keratin 19	Homo sapiens	84-87
22521809-4	2012	Here, we studied the structure and dynamics of the three-repeat domain of tau (i.e. K19) when bound to membranes consisting of a phosphatidylcholine and phosphatidylserine mixture or phosphatidylserine alone.	Phosphatidylserines	183-201	microtubule associated protein tau	Homo sapiens	74-77
22521809-4	2012	Here, we studied the structure and dynamics of the three-repeat domain of tau (i.e. K19) when bound to membranes consisting of a phosphatidylcholine and phosphatidylserine mixture or phosphatidylserine alone.	Phosphatidylserines	183-201	keratin 19	Homo sapiens	84-87
23232054-0	2012	A novel nutritional supplement containing chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron activates the antioxidant pathway Nrf2/HO-1 and protects the brain against oxidative stress in high-fat-fed rats.	Phosphatidylserines	63-81	NFE2 like bZIP transcription factor 2	Rattus norvegicus	149-153
23232054-0	2012	A novel nutritional supplement containing chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron activates the antioxidant pathway Nrf2/HO-1 and protects the brain against oxidative stress in high-fat-fed rats.	Phosphatidylserines	63-81	heme oxygenase 1	Rattus norvegicus	154-158
22740162-4	2012	Annexin V (AnV), which binds surface phosphatidylserine (PS) with high affinity, has been long regarded as a marker of MPs, but AnV binding is Ca2+-dependent and it is unclear how [Ca2+] concentrations could affect AnV binding to MPs and its enumeration.	Phosphatidylserines	37-55	annexin A5	Homo sapiens	0-9
22740162-4	2012	Annexin V (AnV), which binds surface phosphatidylserine (PS) with high affinity, has been long regarded as a marker of MPs, but AnV binding is Ca2+-dependent and it is unclear how [Ca2+] concentrations could affect AnV binding to MPs and its enumeration.	Phosphatidylserines	57-59	annexin A5	Homo sapiens	0-9
22727700-5	2012	Loss of NRF-5 function completely blocks PS appearance on engulfing cells but causes accumulation of PS on apoptotic cells, a phenotype observed in both ced-7(lf) and ttr-52(lf) mutants.	Phosphatidylserines	41-43	Nose resistant to fluoxetine protein 5	Caenorhabditis elegans	8-13
22727700-5	2012	Loss of NRF-5 function completely blocks PS appearance on engulfing cells but causes accumulation of PS on apoptotic cells, a phenotype observed in both ced-7(lf) and ttr-52(lf) mutants.	Phosphatidylserines	101-103	Nose resistant to fluoxetine protein 5	Caenorhabditis elegans	8-13
22727702-9	2012	CONCLUSIONS: CED-7 and TTR-52 may promote the efflux of PS from apoptotic cells through the generation of extracellular PS vesicles, which lead to exPS expression on phagocytes via TTR-52 and CED-1 to facilitate cell corpse clearance.	Phosphatidylserines	56-58	intraflagellar transport 122	Homo sapiens	192-197
22812025-2	2004	PS is also accessible for annexin V (or annexin A5) binding in necrosis because of disruption of the plasma membrane.	Phosphatidylserines	0-2	annexin A5	Mus musculus	26-35
22812025-2	2004	PS is also accessible for annexin V (or annexin A5) binding in necrosis because of disruption of the plasma membrane.	Phosphatidylserines	0-2	annexin A5	Mus musculus	40-50
22812025-3	2004	Annexin V, a 36-kDa protein, binds to PS with high affinity (Kd = 7 nM).	Phosphatidylserines	38-40	annexin A5	Mus musculus	0-9
22465066-3	2012	In the background of POPC membranes SP-B exhibits a certain level of selectivity for anionic fluorescent phospholipids over the corresponding zwitterionic analogues, but apparently no preference for phosphatidylglycerol over other anionic species such as phosphatidylserine.	Phosphatidylserines	255-273	surfactant protein B	Homo sapiens	36-40
21452043-7	2012	Pre-treatment of MPs with either the global caspase inhibitor ZVAD-FMK or Annexin V which blocks phosphatidyl serine in the outer membrane of MPs with high affinity, almost abolished MP-induced apoptosis.	Phosphatidylserines	97-116	annexin A5	Homo sapiens	74-83
22506278-9	2012	In contrast, specific inhibition of ERK1/2 by PD98059 decreases the cell viability and increases pool of phosphatidylserine (PS).	Phosphatidylserines	105-123	mitogen-activated protein kinase 3	Homo sapiens	36-42
22506278-9	2012	In contrast, specific inhibition of ERK1/2 by PD98059 decreases the cell viability and increases pool of phosphatidylserine (PS).	Phosphatidylserines	125-127	mitogen-activated protein kinase 3	Homo sapiens	36-42
22728359-6	2012	Phosphatidylserine (PS) externalization on the outer leaflet of plasma membranes was detected with annexin V-FITC/PI binding, confirming the early stage of apoptosis.	Phosphatidylserines	0-18	annexin A5	Homo sapiens	99-108
22667591-7	2012	Our model properly describes the saturation of lipids on membrane surfaces, and correctly predicts that the MARCKS peptide can consistently sequester three multivalent phosphatidylinositol 4,5-bisphosphate lipids through its basic amino acid residues, regardless of a wide range of the percentage of monovalent phosphatidylserine in the membrane.	Phosphatidylserines	311-329	myristoylated alanine rich protein kinase C substrate	Homo sapiens	108-114
22294729-8	2012	In platelets, loss of caspase-9 confers resistance to the BH3 mimetic ABT-737, blocking phosphatidylserine (PS) exposure and delaying ABT-737-induced thrombocytopenia in vivo.	Phosphatidylserines	88-106	caspase 9	Mus musculus	22-31
22294729-8	2012	In platelets, loss of caspase-9 confers resistance to the BH3 mimetic ABT-737, blocking phosphatidylserine (PS) exposure and delaying ABT-737-induced thrombocytopenia in vivo.	Phosphatidylserines	108-110	caspase 9	Mus musculus	22-31
22351780-7	2012	Unexpectedly, the dephosphorylation rate for the solubilized Drs2p Cdc50p complex was inhibited by the addition of phosphatidylserine.	Phosphatidylserines	115-133	aminophospholipid-translocating P4-type ATPase DRS2	Saccharomyces cerevisiae S288C	61-66
22351780-7	2012	Unexpectedly, the dephosphorylation rate for the solubilized Drs2p Cdc50p complex was inhibited by the addition of phosphatidylserine.	Phosphatidylserines	115-133	aminophospholipid translocase regulatory protein CDC50	Saccharomyces cerevisiae S288C	67-73
22351780-8	2012	Phosphatidylserine exerted its anticipated accelerating effect on the dephosphorylation of Drs2p Cdc50p complex only in the additional presence of phosphatidylinositol-4-phosphate.	Phosphatidylserines	0-18	aminophospholipid-translocating P4-type ATPase DRS2	Saccharomyces cerevisiae S288C	91-96
22351780-8	2012	Phosphatidylserine exerted its anticipated accelerating effect on the dephosphorylation of Drs2p Cdc50p complex only in the additional presence of phosphatidylinositol-4-phosphate.	Phosphatidylserines	0-18	aminophospholipid translocase regulatory protein CDC50	Saccharomyces cerevisiae S288C	97-103
22367206-6	2012	Purified Myo1a bound to liposomes composed of phosphatidylserine and phosphoinositol 4,5-bisphosphate, with moderate affinity in a charge-dependent manner.	Phosphatidylserines	46-64	myosin IA	Homo sapiens	9-14
21920348-1	2012	Lactadherin binds to phosphatidylserine (PS) in a stereospecific and calcium independent manner that is promoted by vesicle curvature.	Phosphatidylserines	21-39	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	0-11
22353012-5	2012	Also, a lipid microemulsion (LME) comprised of olive oil and phosphatidylserine (PS) was used to formulate GDF5 at neutral pH for IN administration.	Phosphatidylserines	61-79	growth differentiation factor 5	Homo sapiens	107-111
22353012-5	2012	Also, a lipid microemulsion (LME) comprised of olive oil and phosphatidylserine (PS) was used to formulate GDF5 at neutral pH for IN administration.	Phosphatidylserines	81-83	growth differentiation factor 5	Homo sapiens	107-111
22189507-3	2012	Using limited proteolysis and mass spectrometry, two peptide regions, which correspond to Ser(100)-Arg(114) and His(89)-Arg(114) in BID, revealed the specific PS-binding site.	Phosphatidylserines	159-161	BH3 interacting domain death agonist	Homo sapiens	132-135
22189507-9	2012	CL and PS also stimulated the insertion of BID into lipid monolayers.	Phosphatidylserines	7-9	BH3 interacting domain death agonist	Homo sapiens	43-46
22370875-10	2012	However, blockade of PS with lactadherin inhibited over 90% of PCA while an anti-tissue factor antibody had no significant inhibition effect.	Phosphatidylserines	21-23	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	29-40
22682124-4	2012	In some cases, PS expression is also associated, in the same MP, with the presence of active Tissue Factor, the main activator of blood coagulation.	Phosphatidylserines	15-17	coagulation factor III, tissue factor	Homo sapiens	93-106
22302738-0	2012	Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells.	Phosphatidylserines	51-69	CD300a molecule	Homo sapiens	6-12
22302738-5	2012	Using surface plasmon resonance, ultracentrifugation, ELISA, and reporter cell assays, we identified phosphatidylethanolamine (PE) and phosphatidylserine (PS), 2 phospholipids that translocate to the outer leaflet of the plasma membrane of dead cells, as the ligands for CD300a.	Phosphatidylserines	135-153	CD300a molecule	Homo sapiens	271-277
22302738-6	2012	Mutational and structural modeling studies identified residues that are involved in the binding of CD300a to PE and PS and that form a cavity where the hydrophilic heads of PE and PS, can penetrate.	Phosphatidylserines	116-118	CD300a molecule	Homo sapiens	99-105
22302738-8	2012	Collectively, our results indicate that PE and PS are ligands for CD300a, and that this interaction plays an important role in regulating the removal of dead cells.	Phosphatidylserines	47-49	CD300a molecule	Homo sapiens	66-72
22385159-2	2012	Previously, we have shown that the C2 domain of PLC delta1 is required for phosphatidylserine (PS)-dependent enzyme activation and that activation requires the presence of Ca(2+).	Phosphatidylserines	75-93	phospholipase C delta 1	Homo sapiens	48-58
22385159-2	2012	Previously, we have shown that the C2 domain of PLC delta1 is required for phosphatidylserine (PS)-dependent enzyme activation and that activation requires the presence of Ca(2+).	Phosphatidylserines	95-97	phospholipase C delta 1	Homo sapiens	48-58
22385159-9	2012	Replacing Asp-653, Asp-706, and Asp-708 simultaneously with glycine in the C2 domain of PLC delta1 leads to a complete and selective loss of the stimulation and binding by PS.	Phosphatidylserines	172-174	phospholipase C delta 1	Homo sapiens	88-98
22415004-1	2012	UNLABELLED: Annexin A5 (AnxA5) has a high affinity for phosphatidylserine.	Phosphatidylserines	55-73	annexin A5	Mus musculus	12-22
22415004-1	2012	UNLABELLED: Annexin A5 (AnxA5) has a high affinity for phosphatidylserine.	Phosphatidylserines	55-73	annexin A5	Mus musculus	24-29
23449275-7	2012	C-reactive protein showed positive correlations with phosphatidylcholine, phosphatidylserine, phosphatidylinositol and total phospholipids in membranes from control subjects.	Phosphatidylserines	74-92	C-reactive protein	Homo sapiens	0-18
22172514-3	2012	Two such enzymes, phosphatidylserine (PS)-specific PLA(1) (PS-PLA(1)) and phosphatidic acid (PA)-selective PLA(1)alpha (PA-PLA(1)alpha, also known as LIPH) specifically hydrolyze PS and PA, respectively.	Phosphatidylserines	38-40	phospholipase A1 member A	Homo sapiens	51-57
22172514-3	2012	Two such enzymes, phosphatidylserine (PS)-specific PLA(1) (PS-PLA(1)) and phosphatidic acid (PA)-selective PLA(1)alpha (PA-PLA(1)alpha, also known as LIPH) specifically hydrolyze PS and PA, respectively.	Phosphatidylserines	38-40	phospholipase A1 member A	Homo sapiens	59-68
22357850-1	2012	Milk-fat globule EGF factor-8 (MFG-E8, SED1, lactadherin) is known to mediate the phagocytic removal of apoptotic cells by bridging phosphatidylserine (PS)-exposing cells and the vitronectin receptor (VR) on phagocytes.	Phosphatidylserines	132-150	milk fat globule EGF and factor V/VIII domain containing	Rattus norvegicus	0-29
22357850-1	2012	Milk-fat globule EGF factor-8 (MFG-E8, SED1, lactadherin) is known to mediate the phagocytic removal of apoptotic cells by bridging phosphatidylserine (PS)-exposing cells and the vitronectin receptor (VR) on phagocytes.	Phosphatidylserines	132-150	milk fat globule EGF and factor V/VIII domain containing	Rattus norvegicus	31-37
22357850-1	2012	Milk-fat globule EGF factor-8 (MFG-E8, SED1, lactadherin) is known to mediate the phagocytic removal of apoptotic cells by bridging phosphatidylserine (PS)-exposing cells and the vitronectin receptor (VR) on phagocytes.	Phosphatidylserines	132-150	milk fat globule EGF and factor V/VIII domain containing	Rattus norvegicus	39-43
22357850-1	2012	Milk-fat globule EGF factor-8 (MFG-E8, SED1, lactadherin) is known to mediate the phagocytic removal of apoptotic cells by bridging phosphatidylserine (PS)-exposing cells and the vitronectin receptor (VR) on phagocytes.	Phosphatidylserines	132-150	milk fat globule EGF and factor V/VIII domain containing	Rattus norvegicus	45-56
22344035-6	2012	Using a reconstituted system with supported lipid bilayers, we show that the relative composition of phosphatidylethanolamine versus phosphatidylserine directly modulates Cdc42 extraction from the membrane by guanine nucleotide dissociation inhibitor.	Phosphatidylserines	133-151	Rho family GTPase CDC42	Saccharomyces cerevisiae S288C	171-176
22215673-5	2012	A FRET assay for the binding of Cdc42 to liposomes of defined composition showed that Cdc42 associates more strongly with liposomes containing phosphatidylinositol 4,5-bisphosphate (PIP(2)) when compared either with uncharged control membranes or with liposomes containing a charge-equivalent amount of phosphatidylserine.	Phosphatidylserines	303-321	cell division cycle 42	Mus musculus	86-91
22215673-5	2012	A FRET assay for the binding of Cdc42 to liposomes of defined composition showed that Cdc42 associates more strongly with liposomes containing phosphatidylinositol 4,5-bisphosphate (PIP(2)) when compared either with uncharged control membranes or with liposomes containing a charge-equivalent amount of phosphatidylserine.	Phosphatidylserines	303-321	prolactin induced protein	Mus musculus	182-185
22308393-3	2012	Here, we identify residues that confer differences in substrate specificity between Drs2 and Dnf1, Saccharomyces cerevisiae P4-ATPases that preferentially flip PS and phosphatidylcholine (PC), respectively.	Phosphatidylserines	160-162	aminophospholipid-translocating P4-type ATPase DRS2	Saccharomyces cerevisiae S288C	84-88
22308393-3	2012	Here, we identify residues that confer differences in substrate specificity between Drs2 and Dnf1, Saccharomyces cerevisiae P4-ATPases that preferentially flip PS and phosphatidylcholine (PC), respectively.	Phosphatidylserines	160-162	aminophospholipid-translocating P4-type ATPase DNF1	Saccharomyces cerevisiae S288C	93-97
22308393-4	2012	Transplanting transmembrane segments 3 and 4 (TM3-4) of Drs2 into Dnf1 alters the substrate preference of Dnf1 from PC to PS.	Phosphatidylserines	122-124	aminophospholipid-translocating P4-type ATPase DRS2	Saccharomyces cerevisiae S288C	56-60
22308393-4	2012	Transplanting transmembrane segments 3 and 4 (TM3-4) of Drs2 into Dnf1 alters the substrate preference of Dnf1 from PC to PS.	Phosphatidylserines	122-124	aminophospholipid-translocating P4-type ATPase DNF1	Saccharomyces cerevisiae S288C	66-70
22308393-4	2012	Transplanting transmembrane segments 3 and 4 (TM3-4) of Drs2 into Dnf1 alters the substrate preference of Dnf1 from PC to PS.	Phosphatidylserines	122-124	aminophospholipid-translocating P4-type ATPase DNF1	Saccharomyces cerevisiae S288C	106-110
22308393-6	2012	The reciprocal Phe511Tyr substitution in Drs2 specifically abrogates PS recognition by this flippase causing PS exposure on the outer leaflet of the plasma membrane without disrupting PE asymmetry.	Phosphatidylserines	69-71	aminophospholipid-translocating P4-type ATPase DRS2	Saccharomyces cerevisiae S288C	41-45
21922137-5	2012	We found fisetin can trigger a             novel form of atypical apoptosis in caspase-3-deficient MCF-7 cells, which was             characterized by several apoptotic features, including plasma membrane rupture,             mitochondrial depolarization, activation of caspase-7, -8 and -9, and PARP cleavage;             however, neither DNA fragmentation and phosphotidylserine (PS) externalization             was observed.	Phosphatidylserines	362-380	caspase 3	Homo sapiens	79-88
21762960-9	2012	RESULTS: Anthracycline treatment of THP-1 cells resulted in a concentration-dependent increase in cellular TF activity without a change in TF protein, which was associated with increased PS exposure on the cell surface and apoptosis.	Phosphatidylserines	187-189	GLI family zinc finger 2	Homo sapiens	36-41
22185693-0	2012	Identification of phosphatidylserine as a ligand for the CD300a immunoreceptor.	Phosphatidylserines	18-36	CD300a molecule	Homo sapiens	57-63
22185693-5	2012	Here, we demonstrate that the chimeric fusion protein of CD300a extracellular domain with the Fc portion of human IgG specifically bound phosphatidylserine (PS), which is exposed on the outer leaflet of the plasma membrane of apoptotic cells.	Phosphatidylserines	137-155	CD300a molecule	Homo sapiens	57-63
22185693-5	2012	Here, we demonstrate that the chimeric fusion protein of CD300a extracellular domain with the Fc portion of human IgG specifically bound phosphatidylserine (PS), which is exposed on the outer leaflet of the plasma membrane of apoptotic cells.	Phosphatidylserines	157-159	CD300a molecule	Homo sapiens	57-63
22185693-6	2012	PS binding to CD300a induced SHP-1 recruitment by CD300a in mast cells in response to LPS.	Phosphatidylserines	0-2	CD300a molecule	Homo sapiens	14-20
22185693-6	2012	PS binding to CD300a induced SHP-1 recruitment by CD300a in mast cells in response to LPS.	Phosphatidylserines	0-2	nuclear receptor subfamily 0 group B member 2	Homo sapiens	29-34
22185693-6	2012	PS binding to CD300a induced SHP-1 recruitment by CD300a in mast cells in response to LPS.	Phosphatidylserines	0-2	CD300a molecule	Homo sapiens	50-56
21933153-7	2012	NBD-tagged alpha-tocopherol binding to PKCalpha or the PKCalpha-C1a domain was blocked by diacylglycerol, alpha-tocopherol, gamma-tocopherol and retinol, but not by cholesterol or PS (phosphatidylserine).	Phosphatidylserines	180-182	protein kinase C alpha	Homo sapiens	39-47
21933153-7	2012	NBD-tagged alpha-tocopherol binding to PKCalpha or the PKCalpha-C1a domain was blocked by diacylglycerol, alpha-tocopherol, gamma-tocopherol and retinol, but not by cholesterol or PS (phosphatidylserine).	Phosphatidylserines	180-182	protein kinase C alpha	Homo sapiens	55-63
21933153-7	2012	NBD-tagged alpha-tocopherol binding to PKCalpha or the PKCalpha-C1a domain was blocked by diacylglycerol, alpha-tocopherol, gamma-tocopherol and retinol, but not by cholesterol or PS (phosphatidylserine).	Phosphatidylserines	184-202	protein kinase C alpha	Homo sapiens	39-47
21933153-7	2012	NBD-tagged alpha-tocopherol binding to PKCalpha or the PKCalpha-C1a domain was blocked by diacylglycerol, alpha-tocopherol, gamma-tocopherol and retinol, but not by cholesterol or PS (phosphatidylserine).	Phosphatidylserines	184-202	protein kinase C alpha	Homo sapiens	55-63
21933153-8	2012	Tocopherols enhanced PKCalpha-C2 domain binding to PS-containing lipid vesicles.	Phosphatidylserines	51-53	protein kinase C alpha	Homo sapiens	21-29
21833550-3	2012	In this study, cells from the RGC-5 line were exposed to different concentrations (2.0, 10, and 50 ng/ml) of TNF-alpha, and the degree of TNF-alpha-induced cell death was determined by the WST-8 assay and by flow cytometric measurements of the externalization of phosphatidylserine.	Phosphatidylserines	263-281	tumor necrosis factor	Homo sapiens	138-147
22201972-3	2012	Exposure of phosphatidylserine (PS) in response to various chemical or pathophysiological stimuli has been considered as the most potent inducer of TF decryption.	Phosphatidylserines	12-30	coagulation factor III, tissue factor	Homo sapiens	148-150
22201972-3	2012	Exposure of phosphatidylserine (PS) in response to various chemical or pathophysiological stimuli has been considered as the most potent inducer of TF decryption.	Phosphatidylserines	32-34	coagulation factor III, tissue factor	Homo sapiens	148-150
22007859-1	2012	The molecule responsible for the enzyme activity plasma membrane (PM) aminophospholipid translocase (APLT), which catalyzes phosphatidylserine (PS) translocation from the outer to the inner leaflet of the plasma membrane, is unknown in mammals.	Phosphatidylserines	124-142	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	Mus musculus	101-105
22870283-3	2012	PS presentation at the cell surface is typically analyzed using fluorescence-labeled annexin V.	Phosphatidylserines	0-2	annexin A5	Homo sapiens	85-94
22505997-3	2012	The equilibrium dissociation constants for the binding of wild type (wt) PTEN to PS and PI(4,5)P(2) were determined to be K(d)~12 microM and 0.4 microM, respectively, and K(d)~50 nM if both lipids are present.	Phosphatidylserines	81-83	phosphatase and tensin homolog	Homo sapiens	73-77
22505997-7	2012	While C124S PTEN has at least the same affinity to PI(4,5)P(2) and an increased apparent affinity to PI(3,4,5)P(3), due to its lack of catalytic activity, H93R PTEN shows a decreased affinity to PI(4,5)P(2) and no synergy in its binding with PS and PI(4,5)P(2).	Phosphatidylserines	242-244	phosphatase and tensin homolog	Homo sapiens	12-16
21971045-0	2011	Phosphatidylserine binding is essential for plasma membrane recruitment and signaling function of 3-phosphoinositide-dependent kinase-1.	Phosphatidylserines	0-18	pyruvate dehydrogenase kinase 1	Homo sapiens	98-135
21971045-3	2011	Our surface plasmon resonance analysis of the PDK1 PH domain and selected mutants shows that the PH domain specifically binds phosphatidylserine using a site that is separate from the canonical phosphoinositide-binding site.	Phosphatidylserines	126-144	pyruvate dehydrogenase kinase 1	Homo sapiens	46-50
21917090-8	2011	PS is mislocalized in intestinal cells with defects in tat-1 or num-1A function.	Phosphatidylserines	0-2	Phospholipid-transporting ATPase tat-1	Caenorhabditis elegans	55-60
22084121-4	2011	Here we show that when lymphoma cells were transformed with a constitutively active form of TMEM16F, they exposed a high level of PS that was comparable to that observed on apoptotic cells.	Phosphatidylserines	130-132	anoctamin 6	Mus musculus	92-99
21903584-5	2011	Abeta greatly increased the phagocytic capacity of microglia and induced phosphatidylserine exposure (an "eat-me" signal) on neuronal processes.	Phosphatidylserines	73-91	amyloid beta precursor protein	Rattus norvegicus	0-5
21954889-0	2011	FVIII binding to PS membranes differs in the activated and non-activated form and can be shielded by annexin A5.	Phosphatidylserines	17-19	coagulation factor VIII	Homo sapiens	0-5
21954889-0	2011	FVIII binding to PS membranes differs in the activated and non-activated form and can be shielded by annexin A5.	Phosphatidylserines	17-19	annexin A5	Homo sapiens	101-111
21954889-5	2011	We find that activated FVIIIa, in contrast to inactivated FVIII, exhibits a striking binding anomaly as a function of PS content, marked by a sharp maximum of the binding constant around 11% PS, which is close to the natural PS content of platelets.	Phosphatidylserines	118-120	coagulation factor VIII	Homo sapiens	23-28
21954889-5	2011	We find that activated FVIIIa, in contrast to inactivated FVIII, exhibits a striking binding anomaly as a function of PS content, marked by a sharp maximum of the binding constant around 11% PS, which is close to the natural PS content of platelets.	Phosphatidylserines	191-193	coagulation factor VIII	Homo sapiens	23-28
21903576-2	2011	Although SSeCKS and PKCalpha bind phosphatidylserine, we demonstrate that phosphatidylserine-independent binding of PKC by SSeCKS is facilitated by two homologous SSeCKS motifs, EG(I/V)(T/S)XWXSFK(K/R)(M/L)VTP(K/R)K(K/R)X(K/R)XXXEXXXE(E/D) (amino acids 592-620 and 741-769).	Phosphatidylserines	34-52	A-kinase anchoring protein 12	Homo sapiens	9-15
21903576-2	2011	Although SSeCKS and PKCalpha bind phosphatidylserine, we demonstrate that phosphatidylserine-independent binding of PKC by SSeCKS is facilitated by two homologous SSeCKS motifs, EG(I/V)(T/S)XWXSFK(K/R)(M/L)VTP(K/R)K(K/R)X(K/R)XXXEXXXE(E/D) (amino acids 592-620 and 741-769).	Phosphatidylserines	34-52	protein kinase C alpha	Homo sapiens	20-28
21903576-2	2011	Although SSeCKS and PKCalpha bind phosphatidylserine, we demonstrate that phosphatidylserine-independent binding of PKC by SSeCKS is facilitated by two homologous SSeCKS motifs, EG(I/V)(T/S)XWXSFK(K/R)(M/L)VTP(K/R)K(K/R)X(K/R)XXXEXXXE(E/D) (amino acids 592-620 and 741-769).	Phosphatidylserines	34-52	protein kinase C alpha	Homo sapiens	20-23
21903576-2	2011	Although SSeCKS and PKCalpha bind phosphatidylserine, we demonstrate that phosphatidylserine-independent binding of PKC by SSeCKS is facilitated by two homologous SSeCKS motifs, EG(I/V)(T/S)XWXSFK(K/R)(M/L)VTP(K/R)K(K/R)X(K/R)XXXEXXXE(E/D) (amino acids 592-620 and 741-769).	Phosphatidylserines	74-92	A-kinase anchoring protein 12	Homo sapiens	123-129
21903576-2	2011	Although SSeCKS and PKCalpha bind phosphatidylserine, we demonstrate that phosphatidylserine-independent binding of PKC by SSeCKS is facilitated by two homologous SSeCKS motifs, EG(I/V)(T/S)XWXSFK(K/R)(M/L)VTP(K/R)K(K/R)X(K/R)XXXEXXXE(E/D) (amino acids 592-620 and 741-769).	Phosphatidylserines	74-92	A kinase (PRKA) anchor protein (gravin) 12	Mus musculus	123-129
21471570-2	2011	SR-PSOX/CXCL16, a scavenger receptor that binds phosphatidylserine and oxidised lipoprotein, has both phagocytic activity and chemotactic properties.	Phosphatidylserines	48-66	chemokine (C-X-C motif) ligand 16	Mus musculus	8-14
20723040-5	2011	Both the engulfment of Huh7(Con1+) ABs and their effects were partially blocked by masking of phosphatidylserine with annexin V and completely inhibited by the class-A scavenger receptor ligand, polyinosinic acid.	Phosphatidylserines	94-112	MIR7-3 host gene	Homo sapiens	23-27
20723040-5	2011	Both the engulfment of Huh7(Con1+) ABs and their effects were partially blocked by masking of phosphatidylserine with annexin V and completely inhibited by the class-A scavenger receptor ligand, polyinosinic acid.	Phosphatidylserines	94-112	annexin A5	Homo sapiens	118-127
21916482-4	2011	However, as little as 1 mol % phosphatidylinositol 4,5-bisphosphate (PI-4,5-P(2)) or 20 mol % phosphatidylserine was found to disperse syntaxin-1A clusters [Murray, D. H., and Tamm, L. K. (2009) Biochemistry 48, 4617-4625].	Phosphatidylserines	94-112	syntaxin 1A	Homo sapiens	135-146
21902184-3	2011	Recombinant TF was relipidated in liposomes of phosphatidylserine/phosphatidylcholine/biotin-linked phosphatidylethanolamine (20:79:1 PS/PC/bPE molar ratio).	Phosphatidylserines	47-65	coagulation factor III, tissue factor	Homo sapiens	12-14
21910971-5	2011	In this paper, localization of PS to the outer leaflet of plasma membrane in proliferating primary myoblasts and during fusion of these myoblasts into myotubes is validated using Annexin V.	Phosphatidylserines	31-33	annexin A5	Homo sapiens	179-188
21830083-2	2011	As an apoptosis monitoring parameter, affinity interaction between phosphatidylserine (PS) and annexin V was chosen.	Phosphatidylserines	67-85	annexin A5	Homo sapiens	95-104
21830083-2	2011	As an apoptosis monitoring parameter, affinity interaction between phosphatidylserine (PS) and annexin V was chosen.	Phosphatidylserines	87-89	annexin A5	Homo sapiens	95-104
21830083-3	2011	First, the specific binding affinity between annexin V and PS in phospholipid bilayers consisting of various molar (0-15%) composition of PS was measured using a surface plasmon resonance biosensor.	Phosphatidylserines	59-61	annexin A5	Homo sapiens	45-54
21830083-3	2011	First, the specific binding affinity between annexin V and PS in phospholipid bilayers consisting of various molar (0-15%) composition of PS was measured using a surface plasmon resonance biosensor.	Phosphatidylserines	138-140	annexin A5	Homo sapiens	45-54
21830083-4	2011	As PS composition increased, the binding level of annexin V increased proportionally.	Phosphatidylserines	3-5	annexin A5	Homo sapiens	50-59
21741705-8	2011	PS exposure was reduced by LOE-908, and only activated at thrombin concentrations that also activate NCCE.	Phosphatidylserines	0-2	coagulation factor II, thrombin	Homo sapiens	58-66
21813603-8	2011	Contrary to previous reports, we found that high concentrations of PS, in the absence of PIPs, also strongly promoted HIV-1 Gag flotation.	Phosphatidylserines	67-69	Pr55(Gag)	Human immunodeficiency virus 1	124-127
21741352-1	2011	Curcumin modulates the activity of protein kinase Calpha (PKCalpha) when assayed in the presence of vesicles including phosphatidylcholine, phosphatidylserine and diacylglycerol.	Phosphatidylserines	140-158	protein kinase C alpha	Homo sapiens	35-56
21741352-1	2011	Curcumin modulates the activity of protein kinase Calpha (PKCalpha) when assayed in the presence of vesicles including phosphatidylcholine, phosphatidylserine and diacylglycerol.	Phosphatidylserines	140-158	protein kinase C alpha	Homo sapiens	58-66
21710238-5	2011	In contrast, [(3)H]glycerol and [(14)C]oleate incorporated into phosphatidylserine (PtdSer) were elevated 2.4-fold (p &lt; 0.05) and 54% (p &lt; 0.05), respectively, upon ABCA1 induction confirming increased PtdSer biosynthesis from these precursors.	Phosphatidylserines	64-82	phospholipid-transporting ATPase ABCA1	Mesocricetus auratus	171-176
21628073-0	2011	Phosphatidylserine inhibits NFkappaB and p38 MAPK activation in human monocyte derived dendritic cells.	Phosphatidylserines	0-18	nuclear factor kappa B subunit 1	Homo sapiens	28-36
21628073-5	2011	Previous studies demonstrated that PS inhibits the expression of MHC and co-stimulatory molecules, the secretion of IL-12p70, and the ability to activate T cells by human monocyte derived DCs.	Phosphatidylserines	35-37	major histocompatibility complex, class I, C	Homo sapiens	65-68
21628073-8	2011	We showed that PS inhibited the activation of nuclear factor-kappaB (NFkappaB) in response to LPS by preventing IkappaBalpha phosphorylation and degradation.	Phosphatidylserines	15-17	nuclear factor kappa B subunit 1	Homo sapiens	46-67
21628073-8	2011	We showed that PS inhibited the activation of nuclear factor-kappaB (NFkappaB) in response to LPS by preventing IkappaBalpha phosphorylation and degradation.	Phosphatidylserines	15-17	nuclear factor kappa B subunit 1	Homo sapiens	69-77
21628073-8	2011	We showed that PS inhibited the activation of nuclear factor-kappaB (NFkappaB) in response to LPS by preventing IkappaBalpha phosphorylation and degradation.	Phosphatidylserines	15-17	NFKB inhibitor alpha	Homo sapiens	112-124
21741384-4	2011	Phosphatidylserine-positive PMVs detected with annexin V-PE were quantified using combined labelling and gating strategies in conjunction with Polysciences Polybead Microspheres (0.2 mum) and BDTrucount tubes.	Phosphatidylserines	0-18	annexin A5	Homo sapiens	47-56
21850779-8	2004	AnxA5 is a cellular protein of 36 kDa and specifically binds to membrane-bound PS with nanomolar affinity in the presence of calcium (Ca(2+)) (3, 6, 7).	Phosphatidylserines	79-81	annexin A5	Homo sapiens	0-5
21850779-24	2004	Both Cys residues are located at the concave side of AnxA5, opposite the convex side that harbors the Ca(2+)/PS binding sites.	Phosphatidylserines	109-111	annexin A5	Homo sapiens	53-58
21850781-8	2004	AnxA5 is a cellular protein of 36 kDa and specifically binds to membrane-bound PS with nanomolar affinity in the presence of calcium (Ca(2+)) (3, 6, 7).	Phosphatidylserines	79-81	annexin A5	Homo sapiens	0-5
21850781-24	2004	Both Cys residues are located at the concave side of AnxA5, opposite the convex side that harbors the Ca(2+)/PS binding sites.	Phosphatidylserines	109-111	annexin A5	Homo sapiens	53-58
21664913-7	2011	Under conditions where the PS content mimics that in the inner leaflet of the cell plasma membrane, the interaction between CaM and CLS becomes undetectable.	Phosphatidylserines	27-29	calmodulin 1	Homo sapiens	124-127
21834184-2	2004	PS is also accessible for annexin V (or annexin A5) binding in necrosis because of disruption of the plasma membrane.	Phosphatidylserines	0-2	annexin A5	Homo sapiens	26-35
21834184-2	2004	PS is also accessible for annexin V (or annexin A5) binding in necrosis because of disruption of the plasma membrane.	Phosphatidylserines	0-2	annexin A5	Homo sapiens	40-50
21834184-3	2004	Annexin V, a 36-kDa protein, binds to PS with high affinity (Kd = 7 nM).	Phosphatidylserines	38-40	annexin A5	Homo sapiens	0-9
21834184-9	2004	The C2A domain of synaptotagmin I (Syt1) binds two to three Ca(2+) ions and also binds anionic phospholipids including PS.	Phosphatidylserines	119-121	synaptotagmin 1	Homo sapiens	18-33
21834184-9	2004	The C2A domain of synaptotagmin I (Syt1) binds two to three Ca(2+) ions and also binds anionic phospholipids including PS.	Phosphatidylserines	119-121	synaptotagmin 1	Homo sapiens	35-39
20946319-3	2011	Diannexin, a recombinant dimer of the endogenous human annexin V protein, binds PS and thus inhibits the adverse effects of PS.	Phosphatidylserines	80-82	annexin A5	Homo sapiens	55-64
20946319-3	2011	Diannexin, a recombinant dimer of the endogenous human annexin V protein, binds PS and thus inhibits the adverse effects of PS.	Phosphatidylserines	124-126	annexin A5	Homo sapiens	55-64
21762413-6	2011	The FCHO2 EFC domain bound to phosphatidylserine and phosphoinositides and deformed the plasma membrane and liposomes into narrow tubes.	Phosphatidylserines	30-48	FCH and mu domain containing endocytic adaptor 2	Homo sapiens	4-9
21610074-6	2011	Independent evidence for lipid demixing is obtained from fluorescence self-quenching of labeled lipid and from natural abundance (13)C NMR, where heteronuclear single quantum correlation spectra reveal Ca(2+)-dependent chemical shift changes for PS, but not for phosphatidylcholine, in the presence of the syt1 C2 domains.	Phosphatidylserines	246-248	synaptotagmin 1	Homo sapiens	306-310
21610074-7	2011	The ability of syt1 to demix PS is observed in a range of lipid mixtures that includes cholesterol, phosphatidylethanolamine, and varied PS content.	Phosphatidylserines	29-31	synaptotagmin 1	Homo sapiens	15-19
21598295-5	2011	The translocation of phosphatidyl serine and loss of mitochondrial potential was revealed by annexin V-Cy3 staining and JC-1 staining respectively.	Phosphatidylserines	21-40	annexin A5	Homo sapiens	93-102
21440374-5	2011	Annexin V has a high affinity for phosphatidylserine (PS) that presents on the outer surface of the plasma membrane early on during the onset of apoptosis.	Phosphatidylserines	34-52	annexin A5	Homo sapiens	0-9
21440374-5	2011	Annexin V has a high affinity for phosphatidylserine (PS) that presents on the outer surface of the plasma membrane early on during the onset of apoptosis.	Phosphatidylserines	54-56	annexin A5	Homo sapiens	0-9
21557977-0	2011	Enhancing the potency of a whole-cell breast cancer vaccine in mice with an antibody-IL-2 immunocytokine that targets exposed phosphatidylserine.	Phosphatidylserines	126-144	interleukin 2	Mus musculus	85-89
21557977-4	2011	An immunocytokine (2aG4-IL2) was made by genetically linking IL-2 with a PS targeting antibody, 2aG4, that can block the immunosuppressive effects of PS.	Phosphatidylserines	73-75	interleukin 2	Mus musculus	24-27
21557977-4	2011	An immunocytokine (2aG4-IL2) was made by genetically linking IL-2 with a PS targeting antibody, 2aG4, that can block the immunosuppressive effects of PS.	Phosphatidylserines	73-75	interleukin 2	Mus musculus	61-65
21521689-7	2011	Upon reconstitution into proteoliposomes, the ATPase activity of Aus1 was specifically stimulated by phosphatidylserine (PS) in a stereoselective manner.	Phosphatidylserines	101-119	ATP-binding cassette sterol transporter AUS1	Saccharomyces cerevisiae S288C	65-69
21521689-7	2011	Upon reconstitution into proteoliposomes, the ATPase activity of Aus1 was specifically stimulated by phosphatidylserine (PS) in a stereoselective manner.	Phosphatidylserines	121-123	ATP-binding cassette sterol transporter AUS1	Saccharomyces cerevisiae S288C	65-69
21521689-8	2011	We also found that Aus1-dependent sterol uptake, but not Aus1 expression and trafficking to the plasma membrane, was affected by changes in cellular PS levels.	Phosphatidylserines	149-151	ATP-binding cassette sterol transporter AUS1	Saccharomyces cerevisiae S288C	19-23
21677356-8	2011	Phosphatidylserine promotes neuronal survival by translocation/activation of kinase Akt and Raf-1/MEK.	Phosphatidylserines	0-18	AKT serine/threonine kinase 1	Homo sapiens	84-87
21677356-8	2011	Phosphatidylserine promotes neuronal survival by translocation/activation of kinase Akt and Raf-1/MEK.	Phosphatidylserines	0-18	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	92-97
21677356-8	2011	Phosphatidylserine promotes neuronal survival by translocation/activation of kinase Akt and Raf-1/MEK.	Phosphatidylserines	0-18	mitogen-activated protein kinase kinase 7	Homo sapiens	98-101
20201728-6	2011	Also, the loss of phosphatidylserine (PS) asymmetry in the phospholipid bilayer of plasma membrane during early apoptosis was monitored by imaging annexin-V labeled with fluorescein isocyanate binding to the externalized PS at various concentrations of STS.	Phosphatidylserines	18-36	annexin A5	Mus musculus	147-156
20201728-6	2011	Also, the loss of phosphatidylserine (PS) asymmetry in the phospholipid bilayer of plasma membrane during early apoptosis was monitored by imaging annexin-V labeled with fluorescein isocyanate binding to the externalized PS at various concentrations of STS.	Phosphatidylserines	38-40	annexin A5	Mus musculus	147-156
21502377-11	2011	These results demonstrate a novel role for RAGE in which it is able to enhance efferocytosis through binding to PS on apoptotic cells.	Phosphatidylserines	112-114	advanced glycosylation end product-specific receptor	Mus musculus	43-47
21571801-3	2011	METHODS: To modulate the pharmacokinetics of annexin A5, a 36-kDa protein that binds specifically with phosphatidylserine, annexin A5 was conjugated to polyethylene glycol-coated, core-cross-linked polymeric micelles (CCPMs) dually labeled with near-infrared fluorescence fluorophores and a radioisotope ((111)In).	Phosphatidylserines	103-121	annexin A5	Mus musculus	45-55
21571801-3	2011	METHODS: To modulate the pharmacokinetics of annexin A5, a 36-kDa protein that binds specifically with phosphatidylserine, annexin A5 was conjugated to polyethylene glycol-coated, core-cross-linked polymeric micelles (CCPMs) dually labeled with near-infrared fluorescence fluorophores and a radioisotope ((111)In).	Phosphatidylserines	103-121	annexin A5	Mus musculus	123-133
21198999-9	2011	RESULTS: Lactadherin detected 1 5% PS-positive stored RBCs vs 0 5% for annexin V after 14 days of storage, which significantly reached 18 4 vs 4 5% after 42 days of storage.	Phosphatidylserines	35-37	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	9-20
21427291-4	2011	HSECs mediate tethering of damaged RBCs in a PS-dependent manner via stabilin-1 and stabilin-2.	Phosphatidylserines	45-47	stabilin 1	Mus musculus	69-79
21427291-4	2011	HSECs mediate tethering of damaged RBCs in a PS-dependent manner via stabilin-1 and stabilin-2.	Phosphatidylserines	45-47	stabilin 2	Mus musculus	84-94
21454708-13	2011	We conclude that two consecutive processes not previously related to LD biogenesis, (i) PE production via PS and (ii) PE conversion via PEMT, are implicated in LD formation and stability.	Phosphatidylserines	106-108	phosphatidylethanolamine N-methyltransferase	Mus musculus	136-140
21272920-10	2011	By blocking PS, lactadherin was able to inhibit over 90% of the intrinsic tenase/prothrombinase activity of As(2)O(3)-treated HUVECs, and restored coagulation times of As(2)O(3)-treated cells and microparticles to control levels.	Phosphatidylserines	12-14	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	16-27
21296386-2	2011	Aminophospholipid translocase (APLT) can transport PS from the outer to the inner membrane leaflet.	Phosphatidylserines	51-53	ATPase phospholipid transporting 8A1	Homo sapiens	0-29
21296386-2	2011	Aminophospholipid translocase (APLT) can transport PS from the outer to the inner membrane leaflet.	Phosphatidylserines	51-53	ATPase phospholipid transporting 8A1	Homo sapiens	31-35
21296386-4	2011	METHODS: Phorbol 12-myristate 13-acetate (PMA), a well-known PKC activator, and thrombin were used to induce PS exposure on platelet surface.	Phosphatidylserines	109-111	coagulation factor II, thrombin	Homo sapiens	80-88
21352829-8	2011	The polar head of PS was shown to bind to CRT with a 10-fold higher affinity (K(D)=1.5 x 10(-5) M) than that determined for C1q, and, accordingly, the C1q GR-PS interaction was impaired in the presence of CRT.	Phosphatidylserines	18-20	complement C1q A chain	Homo sapiens	124-127
21352829-7	2011	The interaction between CRT and phosphatidylserine (PS), a known C1q ligand on apoptotic cells, was also investigated.	Phosphatidylserines	32-50	complement C1q A chain	Homo sapiens	65-68
21352829-8	2011	The polar head of PS was shown to bind to CRT with a 10-fold higher affinity (K(D)=1.5 x 10(-5) M) than that determined for C1q, and, accordingly, the C1q GR-PS interaction was impaired in the presence of CRT.	Phosphatidylserines	18-20	calreticulin	Homo sapiens	42-45
21352829-8	2011	The polar head of PS was shown to bind to CRT with a 10-fold higher affinity (K(D)=1.5 x 10(-5) M) than that determined for C1q, and, accordingly, the C1q GR-PS interaction was impaired in the presence of CRT.	Phosphatidylserines	18-20	complement C1q A chain	Homo sapiens	151-154
21352829-8	2011	The polar head of PS was shown to bind to CRT with a 10-fold higher affinity (K(D)=1.5 x 10(-5) M) than that determined for C1q, and, accordingly, the C1q GR-PS interaction was impaired in the presence of CRT.	Phosphatidylserines	18-20	calreticulin	Homo sapiens	205-208
21352829-8	2011	The polar head of PS was shown to bind to CRT with a 10-fold higher affinity (K(D)=1.5 x 10(-5) M) than that determined for C1q, and, accordingly, the C1q GR-PS interaction was impaired in the presence of CRT.	Phosphatidylserines	158-160	calreticulin	Homo sapiens	42-45
21352829-8	2011	The polar head of PS was shown to bind to CRT with a 10-fold higher affinity (K(D)=1.5 x 10(-5) M) than that determined for C1q, and, accordingly, the C1q GR-PS interaction was impaired in the presence of CRT.	Phosphatidylserines	158-160	complement C1q A chain	Homo sapiens	151-154
21542558-19	2004	PS is also accessible for annexin V (or annexin A5) binding in necrosis because of disruption of the plasma membrane.	Phosphatidylserines	0-2	annexin A5	Mus musculus	26-35
21542558-19	2004	PS is also accessible for annexin V (or annexin A5) binding in necrosis because of disruption of the plasma membrane.	Phosphatidylserines	0-2	annexin A5	Mus musculus	40-50
21542558-20	2004	Annexin V, a 36-kDa protein, binds to PS with high affinity (Kd = 7 nM).	Phosphatidylserines	38-40	annexin A5	Mus musculus	0-9
21540829-6	2011	In this method, lipid vesicles are prepared with the target lipid and phosphatidylserine as the anchor lipid for Annexin V MACS.	Phosphatidylserines	70-88	annexin A5	Homo sapiens	113-122
21540829-7	2011	Phosphatidylserine is a ubiquitous cell membrane phospholipid that shows high affinity to the protein Annexin V.	Phosphatidylserines	0-18	annexin A5	Homo sapiens	102-111
21540829-8	2011	Using magnetic beads conjugated to Annexin V the phosphatidylserine-containing lipid vesicles will bind to the magnetic beads.	Phosphatidylserines	49-67	annexin A5	Homo sapiens	35-44
21339289-7	2011	Scrutinizing this parameter reveals that CD38(+/+) platelets fully express PS on the surface when stimulated with thrombin, whereas this response was decreased on CD38(-/-) platelets.	Phosphatidylserines	75-77	CD38 antigen	Mus musculus	41-45
21339289-7	2011	Scrutinizing this parameter reveals that CD38(+/+) platelets fully express PS on the surface when stimulated with thrombin, whereas this response was decreased on CD38(-/-) platelets.	Phosphatidylserines	75-77	coagulation factor II	Mus musculus	114-122
21402900-4	2011	Specifically, two inflammatory bacterial ligands, lipoteichoic acid or LPS (agonists of glial TLR2 and TLR4, respectively), stimulated microglial proliferation, phagocytic activity, and engulfment of ~30% of neurons within 3 d. Phagocytosis of neurons was dependent on the microglial release of soluble mediators (and peroxynitrite in particular), which induced neuronal exposure of the eat-me signal phosphatidylserine (PS).	Phosphatidylserines	401-419	toll-like receptor 2	Rattus norvegicus	94-98
21402900-4	2011	Specifically, two inflammatory bacterial ligands, lipoteichoic acid or LPS (agonists of glial TLR2 and TLR4, respectively), stimulated microglial proliferation, phagocytic activity, and engulfment of ~30% of neurons within 3 d. Phagocytosis of neurons was dependent on the microglial release of soluble mediators (and peroxynitrite in particular), which induced neuronal exposure of the eat-me signal phosphatidylserine (PS).	Phosphatidylserines	401-419	toll-like receptor 4	Rattus norvegicus	103-107
21344950-2	2011	Using site-directed spin labeling, the position and membrane interactions of a fragment of syt1 containing its two C2 domains (syt1C2AB) were assessed in bilayers containing phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylinositol 4,5-bisphosphate (PIP(2)).	Phosphatidylserines	220-222	synaptotagmin 1	Homo sapiens	91-95
21344950-3	2011	Addition of 1 mol % PIP(2) to a lipid mixture of PC and PS results in a deeper membrane penetration of the C2A domain and alters the orientation of the C2B domain so that the polybasic face of C2B comes into the proximity of the bilayer interface.	Phosphatidylserines	56-58	prolactin induced protein	Homo sapiens	20-23
21344950-3	2011	Addition of 1 mol % PIP(2) to a lipid mixture of PC and PS results in a deeper membrane penetration of the C2A domain and alters the orientation of the C2B domain so that the polybasic face of C2B comes into the proximity of the bilayer interface.	Phosphatidylserines	56-58	secretoglobin family 2B member 3, pseudogene	Homo sapiens	152-155
21344950-3	2011	Addition of 1 mol % PIP(2) to a lipid mixture of PC and PS results in a deeper membrane penetration of the C2A domain and alters the orientation of the C2B domain so that the polybasic face of C2B comes into the proximity of the bilayer interface.	Phosphatidylserines	56-58	secretoglobin family 2B member 3, pseudogene	Homo sapiens	193-196
21315353-5	2011	METHODS AND RESULTS: Rhodamine isothiocyanate-labeled HDL3 bound specifically to platelets and HDL3 binding was inhibited by scavenger receptor class B ligands such as phosphatidylserine (PS)- or phosphatidylinositol (PI)-containing liposomes or maleylated albumin (mBSA).	Phosphatidylserines	168-186	high density lipoprotein (HDL) level 3	Mus musculus	54-58
21315353-5	2011	METHODS AND RESULTS: Rhodamine isothiocyanate-labeled HDL3 bound specifically to platelets and HDL3 binding was inhibited by scavenger receptor class B ligands such as phosphatidylserine (PS)- or phosphatidylinositol (PI)-containing liposomes or maleylated albumin (mBSA).	Phosphatidylserines	168-186	high density lipoprotein (HDL) level 3	Mus musculus	95-99
21315353-5	2011	METHODS AND RESULTS: Rhodamine isothiocyanate-labeled HDL3 bound specifically to platelets and HDL3 binding was inhibited by scavenger receptor class B ligands such as phosphatidylserine (PS)- or phosphatidylinositol (PI)-containing liposomes or maleylated albumin (mBSA).	Phosphatidylserines	188-190	high density lipoprotein (HDL) level 3	Mus musculus	54-58
21315353-5	2011	METHODS AND RESULTS: Rhodamine isothiocyanate-labeled HDL3 bound specifically to platelets and HDL3 binding was inhibited by scavenger receptor class B ligands such as phosphatidylserine (PS)- or phosphatidylinositol (PI)-containing liposomes or maleylated albumin (mBSA).	Phosphatidylserines	188-190	high density lipoprotein (HDL) level 3	Mus musculus	95-99
21315353-8	2011	In addition, PS- and PI-liposomes emulated HDL3-induced intracellular signaling cascades including diacylglycerol production and protein kinase C activation.	Phosphatidylserines	13-15	high density lipoprotein (HDL) level 3	Mus musculus	43-47
21402788-0	2011	Phosphatidylserine is a critical modulator for Akt activation.	Phosphatidylserines	0-18	AKT serine/threonine kinase 1	Homo sapiens	47-50
21402788-2	2011	Here, we demonstrate that Akt activation requires not only PIP(3) but also membrane phosphatidylserine (PS).	Phosphatidylserines	84-102	AKT serine/threonine kinase 1	Homo sapiens	26-29
21402788-2	2011	Here, we demonstrate that Akt activation requires not only PIP(3) but also membrane phosphatidylserine (PS).	Phosphatidylserines	104-106	AKT serine/threonine kinase 1	Homo sapiens	26-29
21402788-3	2011	The extent of insulin-like growth factor-induced Akt activation and downstream signaling as well as cell survival under serum starvation conditions positively correlates with plasma membrane PS levels in living cells.	Phosphatidylserines	191-193	AKT serine/threonine kinase 1	Homo sapiens	49-52
21402788-4	2011	PS promotes Akt-PIP(3) binding, participates in PIP(3)-induced Akt interdomain conformational changes for T308 phosphorylation, and causes an open conformation that allows for S473 phosphorylation by mTORC2.	Phosphatidylserines	0-2	AKT serine/threonine kinase 1	Homo sapiens	12-15
21402788-4	2011	PS promotes Akt-PIP(3) binding, participates in PIP(3)-induced Akt interdomain conformational changes for T308 phosphorylation, and causes an open conformation that allows for S473 phosphorylation by mTORC2.	Phosphatidylserines	0-2	AKT serine/threonine kinase 1	Homo sapiens	63-66
21402788-4	2011	PS promotes Akt-PIP(3) binding, participates in PIP(3)-induced Akt interdomain conformational changes for T308 phosphorylation, and causes an open conformation that allows for S473 phosphorylation by mTORC2.	Phosphatidylserines	0-2	CREB regulated transcription coactivator 2	Mus musculus	200-206
21138397-6	2011	Greater exposure of phosphatidyl serine (PS) residue vindicated by annexin V binding and lesser accumulation of mitotracker red in mitochondrial matrix demonstrated initiation of apoptosis in ALS platelets.	Phosphatidylserines	41-43	annexin A5	Homo sapiens	67-76
21347838-0	2011	Glycation of the muscle-specific enolase by reactive carbonyls: effect of temperature and the protection role of carnosine, pyridoxamine and phosphatidylserine.	Phosphatidylserines	141-159	enolase 3	Homo sapiens	17-40
21370219-9	2011	Phosphatidylserine, a phospholipid, and thrombin-activatable fibrinolysis inhibitor (TAFI) are novel components of AF.	Phosphatidylserines	0-18	carboxypeptidase B2	Homo sapiens	85-89
21094627-7	2011	A possible mechanism for PS-mediated induction of FVIII tolerance is discussed.	Phosphatidylserines	25-27	coagulation factor VIII	Mus musculus	50-55
21156029-5	2011	In the present study, we show that BASP1 induces single channel currents across negatively-charged planar lipid bilayers (containing phosphatidylserine or PIP(2)) bathed in 0.1-0.2 M KCl (pH 7.5).	Phosphatidylserines	133-151	brain abundant membrane attached signal protein 1	Homo sapiens	35-40
20963452-4	2011	Compared with [(18)F]-labeled annexin V, which binds to externalized phosphatidylserine (PS) on the outer membrane of apoptotic cells, intracellular uptake of the dansylhydrazone of p-fluorobenzaldehyde (DFNSH) may lead to improved target-to-background contrast ratios.	Phosphatidylserines	69-87	annexin A5	Rattus norvegicus	30-39
20963452-4	2011	Compared with [(18)F]-labeled annexin V, which binds to externalized phosphatidylserine (PS) on the outer membrane of apoptotic cells, intracellular uptake of the dansylhydrazone of p-fluorobenzaldehyde (DFNSH) may lead to improved target-to-background contrast ratios.	Phosphatidylserines	89-91	annexin A5	Rattus norvegicus	30-39
21040449-6	2011	RESULTS: H2B interacted directly with PS via an electrostatic interaction.	Phosphatidylserines	38-40	H2B clustered histone 21	Homo sapiens	9-12
21040449-7	2011	Anti-PS or PS binding proteins, annexin V and protein S, diminished H2B interaction with PS on the surface of differentiated or apoptotic cells and these same reagents inhibited Plg binding to these cells.	Phosphatidylserines	5-7	H2B clustered histone 21	Homo sapiens	68-71
21040449-7	2011	Anti-PS or PS binding proteins, annexin V and protein S, diminished H2B interaction with PS on the surface of differentiated or apoptotic cells and these same reagents inhibited Plg binding to these cells.	Phosphatidylserines	5-7	plasminogen	Homo sapiens	178-181
21040449-7	2011	Anti-PS or PS binding proteins, annexin V and protein S, diminished H2B interaction with PS on the surface of differentiated or apoptotic cells and these same reagents inhibited Plg binding to these cells.	Phosphatidylserines	11-13	H2B clustered histone 21	Homo sapiens	68-71
21040449-7	2011	Anti-PS or PS binding proteins, annexin V and protein S, diminished H2B interaction with PS on the surface of differentiated or apoptotic cells and these same reagents inhibited Plg binding to these cells.	Phosphatidylserines	11-13	plasminogen	Homo sapiens	178-181
21040449-7	2011	Anti-PS or PS binding proteins, annexin V and protein S, diminished H2B interaction with PS on the surface of differentiated or apoptotic cells and these same reagents inhibited Plg binding to these cells.	Phosphatidylserines	11-13	H2B clustered histone 21	Homo sapiens	68-71
21040449-7	2011	Anti-PS or PS binding proteins, annexin V and protein S, diminished H2B interaction with PS on the surface of differentiated or apoptotic cells and these same reagents inhibited Plg binding to these cells.	Phosphatidylserines	11-13	plasminogen	Homo sapiens	178-181
21040449-11	2011	The exposed PS interacts directly with H2B and hence provides sites for Plg to bind to.	Phosphatidylserines	12-14	H2B clustered histone 21	Homo sapiens	39-42
21040449-11	2011	The exposed PS interacts directly with H2B and hence provides sites for Plg to bind to.	Phosphatidylserines	12-14	plasminogen	Homo sapiens	72-75
20963507-6	2011	In addition, higher levels of docosahexaenoic acid were found in PtdSer and phosphatidylethanolamine (PtdEtn) from the cerebral cortex of gamma-synuclein null mutant mice.	Phosphatidylserines	65-71	synuclein, gamma	Mus musculus	138-153
21080035-6	2011	Binding of prothrombin to a surface containing 20% phosphatidylserine/80% phosphatidylcholine was detected by surface plasmon resonance, whereas no interaction with gla-domainless prothrombin was observed.	Phosphatidylserines	51-69	coagulation factor II, thrombin	Homo sapiens	11-22
21078669-4	2011	anxA5 binds PS and crystallizes in a two-dimensional network covering the PS-expressing cell surface.	Phosphatidylserines	12-14	annexin A5	Homo sapiens	0-5
21415529-3	2011	When MGST1 was mixed with liposomes of cardiolipin (CL), phosphatidylcholine (PC), phosphatidylserine (PC), or phosphatidylethanolamine (PE), its activity was increased in a magnitude which was dependent on the anionic property of lipids in the order of CL&gt;PS&gt;PE&gt;PC, indicating that MGST1 activity is enhanced by surrounding anionic lipids.	Phosphatidylserines	83-101	microsomal glutathione S-transferase 1	Homo sapiens	5-10
21629847-1	2011	Annexin A5 has been used for the detection of apoptotic cells, due to its ability to bind to phosphatidylserine (PS).	Phosphatidylserines	93-111	annexin A5	Macaca mulatta	0-10
21629847-1	2011	Annexin A5 has been used for the detection of apoptotic cells, due to its ability to bind to phosphatidylserine (PS).	Phosphatidylserines	113-115	annexin A5	Macaca mulatta	0-10
21468968-3	2011	PS can be stained by labeled annexin V.	Phosphatidylserines	0-2	annexin A5	Homo sapiens	29-38
21441608-1	2011	Protein kinase Cepsilon (PKCepsilon) is a representative member of a family of novel PKC isoforms that are independent of calcium, but can be activated by phorbol esters, diacylglycerol (DAG) and phosphatidylserine (PS).	Phosphatidylserines	196-214	protein kinase C epsilon	Homo sapiens	0-23
21441608-1	2011	Protein kinase Cepsilon (PKCepsilon) is a representative member of a family of novel PKC isoforms that are independent of calcium, but can be activated by phorbol esters, diacylglycerol (DAG) and phosphatidylserine (PS).	Phosphatidylserines	196-214	protein kinase C epsilon	Homo sapiens	25-35
21441608-1	2011	Protein kinase Cepsilon (PKCepsilon) is a representative member of a family of novel PKC isoforms that are independent of calcium, but can be activated by phorbol esters, diacylglycerol (DAG) and phosphatidylserine (PS).	Phosphatidylserines	196-214	protein kinase C epsilon	Homo sapiens	25-28
21441608-1	2011	Protein kinase Cepsilon (PKCepsilon) is a representative member of a family of novel PKC isoforms that are independent of calcium, but can be activated by phorbol esters, diacylglycerol (DAG) and phosphatidylserine (PS).	Phosphatidylserines	216-218	protein kinase C epsilon	Homo sapiens	0-23
21441608-1	2011	Protein kinase Cepsilon (PKCepsilon) is a representative member of a family of novel PKC isoforms that are independent of calcium, but can be activated by phorbol esters, diacylglycerol (DAG) and phosphatidylserine (PS).	Phosphatidylserines	216-218	protein kinase C epsilon	Homo sapiens	25-35
21441608-1	2011	Protein kinase Cepsilon (PKCepsilon) is a representative member of a family of novel PKC isoforms that are independent of calcium, but can be activated by phorbol esters, diacylglycerol (DAG) and phosphatidylserine (PS).	Phosphatidylserines	216-218	protein kinase C epsilon	Homo sapiens	25-28
21074554-1	2011	A phospholipase A2 was identified from MDCK cell homogenates with broad specificity toward glycerophospholipids including phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylglycerol.	Phosphatidylserines	169-187	phospholipase A2 group IB	Canis lupus familiaris	2-18
21209961-0	2010	Phosphatidylserine increases IKBKAP levels in familial dysautonomia cells.	Phosphatidylserines	0-18	elongator acetyltransferase complex subunit 1	Homo sapiens	29-35
21209961-4	2010	Here we show that phosphatidylserine (PS), an FDA-approved food supplement, increased IKAP mRNA levels in cells derived from FD patients.	Phosphatidylserines	18-36	elongator acetyltransferase complex subunit 1	Homo sapiens	86-90
21209961-4	2010	Here we show that phosphatidylserine (PS), an FDA-approved food supplement, increased IKAP mRNA levels in cells derived from FD patients.	Phosphatidylserines	38-40	elongator acetyltransferase complex subunit 1	Homo sapiens	86-90
21209961-5	2010	Long-term treatment with PS led to a significant increase in IKAP protein levels in these cells.	Phosphatidylserines	25-27	elongator acetyltransferase complex subunit 1	Homo sapiens	61-65
21209961-6	2010	A conjugate of PS and an omega-3 fatty acid also increased IKAP mRNA levels.	Phosphatidylserines	15-17	elongator acetyltransferase complex subunit 1	Homo sapiens	59-63
20705065-8	2010	Flow cytometry was used to analyze the binding of fluorescence-labeled annexin A5 to phosphatidylserine (PS)-translocated intact cells in the presence of Lp(a).	Phosphatidylserines	85-103	annexin A5	Homo sapiens	71-81
20886178-12	2010	Blockade of PS with lactadherin inhibited over 90% of HUVECs and EMPs PCA.	Phosphatidylserines	12-14	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	20-31
20860408-4	2010	We found that the myo1e tail binds tightly to large unilamellar vesicles (LUVs) containing physiological concentrations of the anionic phospholipids phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) or phosphatidylserine.	Phosphatidylserines	208-226	myosin IE	Homo sapiens	18-23
20925360-5	2010	Possible lipid binding sites on the surface of Osh4 were identified by docking four lipid moieties modeled from different lipid head groups (phosphatidylcholine, phosphatidylserine, phosphatidylinositol(4,5)biphosphate, and phosphatidylinositol(3,4,5)triphosphate).	Phosphatidylserines	162-180	oxysterol-binding protein KES1	Saccharomyces cerevisiae S288C	47-51
20930481-6	2010	Phosphatidylserine and phosphatidylglycerol were also reported to trigger fibril formation by human islet amyloid polypeptide (hIAPP).	Phosphatidylserines	0-18	islet amyloid polypeptide	Homo sapiens	127-132
20659476-4	2010	Recent EPR studies have revealed the membrane docking geometries of the PKCalpha C2 domain docked to (i) PS alone and (ii) both PS and PIP(2) simultaneously.	Phosphatidylserines	105-107	protein kinase C alpha	Homo sapiens	72-80
20659476-4	2010	Recent EPR studies have revealed the membrane docking geometries of the PKCalpha C2 domain docked to (i) PS alone and (ii) both PS and PIP(2) simultaneously.	Phosphatidylserines	128-130	protein kinase C alpha	Homo sapiens	72-80
20624402-4	2010	Here, we show that under apoptotic stress conditions, the cytosolic concentration of CRT increases and associates with phosphatidylserine (PS) in a Ca(2)(+)-dependent manner.	Phosphatidylserines	119-137	calreticulin	Homo sapiens	85-88
20624402-4	2010	Here, we show that under apoptotic stress conditions, the cytosolic concentration of CRT increases and associates with phosphatidylserine (PS) in a Ca(2)(+)-dependent manner.	Phosphatidylserines	139-141	calreticulin	Homo sapiens	85-88
20624402-5	2010	PS distribution is regulated by aminophospholipid translocase (APLT), which maintains PS on the cytosolic side of the cell membrane.	Phosphatidylserines	0-2	ATPase phospholipid transporting 8A1	Homo sapiens	32-61
20624402-5	2010	PS distribution is regulated by aminophospholipid translocase (APLT), which maintains PS on the cytosolic side of the cell membrane.	Phosphatidylserines	0-2	ATPase phospholipid transporting 8A1	Homo sapiens	63-67
20624402-5	2010	PS distribution is regulated by aminophospholipid translocase (APLT), which maintains PS on the cytosolic side of the cell membrane.	Phosphatidylserines	86-88	ATPase phospholipid transporting 8A1	Homo sapiens	32-61
20624402-5	2010	PS distribution is regulated by aminophospholipid translocase (APLT), which maintains PS on the cytosolic side of the cell membrane.	Phosphatidylserines	86-88	ATPase phospholipid transporting 8A1	Homo sapiens	63-67
20624402-8	2010	By using S-nitroso-l-cysteine-ethyl-ester, an intracellular NO donor and inhibitor of APLT, we showed that PS and CRT externalization occurred together in an S-nitrosothiol-dependent and caspase-independent manner.	Phosphatidylserines	107-109	ATPase phospholipid transporting 8A1	Homo sapiens	86-90
20570648-5	2010	Here we investigate the structure and aggregation properties of hIAPP(1-19) in relation to membrane damage in vitro by using membranes of the zwitterionic lipid phosphatidylcholine (PC), the anionic lipid phosphatidylserine (PS) and mixtures of these lipids to mimic membranes of islet cells.	Phosphatidylserines	205-223	islet amyloid polypeptide	Homo sapiens	64-69
20570648-5	2010	Here we investigate the structure and aggregation properties of hIAPP(1-19) in relation to membrane damage in vitro by using membranes of the zwitterionic lipid phosphatidylcholine (PC), the anionic lipid phosphatidylserine (PS) and mixtures of these lipids to mimic membranes of islet cells.	Phosphatidylserines	225-227	islet amyloid polypeptide	Homo sapiens	64-69
20427706-4	2010	Energy depletion increased [Ca(2+)](i) and phosphatidylserine-exposure, effects significantly blunted by ET1 (IC(50) approximately 100 nM) and the ETB receptor-agonist sarafotoxin 6c (IC(50) approximately 10 nM) but not by ET2 and ET3.	Phosphatidylserines	43-61	endothelin 1	Mus musculus	105-108
20579763-6	2010	Analysis of PL species profiles revealed that GM-CSF/IL-4 differentiated cells have increased amounts of longer and more desaturated phospatidylethanolamine (PE) and phosphatidylserine (PS) species, but lower amounts of shorter and less desaturated PE and PS species than M-CSF differentiated cells.	Phosphatidylserines	166-184	colony stimulating factor 2	Homo sapiens	46-52
20579763-6	2010	Analysis of PL species profiles revealed that GM-CSF/IL-4 differentiated cells have increased amounts of longer and more desaturated phospatidylethanolamine (PE) and phosphatidylserine (PS) species, but lower amounts of shorter and less desaturated PE and PS species than M-CSF differentiated cells.	Phosphatidylserines	166-184	interleukin 4	Homo sapiens	53-57
20579763-6	2010	Analysis of PL species profiles revealed that GM-CSF/IL-4 differentiated cells have increased amounts of longer and more desaturated phospatidylethanolamine (PE) and phosphatidylserine (PS) species, but lower amounts of shorter and less desaturated PE and PS species than M-CSF differentiated cells.	Phosphatidylserines	166-184	colony stimulating factor 1	Homo sapiens	47-52
20579763-6	2010	Analysis of PL species profiles revealed that GM-CSF/IL-4 differentiated cells have increased amounts of longer and more desaturated phospatidylethanolamine (PE) and phosphatidylserine (PS) species, but lower amounts of shorter and less desaturated PE and PS species than M-CSF differentiated cells.	Phosphatidylserines	186-188	colony stimulating factor 2	Homo sapiens	46-52
20579763-6	2010	Analysis of PL species profiles revealed that GM-CSF/IL-4 differentiated cells have increased amounts of longer and more desaturated phospatidylethanolamine (PE) and phosphatidylserine (PS) species, but lower amounts of shorter and less desaturated PE and PS species than M-CSF differentiated cells.	Phosphatidylserines	186-188	interleukin 4	Homo sapiens	53-57
20579763-6	2010	Analysis of PL species profiles revealed that GM-CSF/IL-4 differentiated cells have increased amounts of longer and more desaturated phospatidylethanolamine (PE) and phosphatidylserine (PS) species, but lower amounts of shorter and less desaturated PE and PS species than M-CSF differentiated cells.	Phosphatidylserines	186-188	colony stimulating factor 1	Homo sapiens	47-52
20796191-5	2010	The apoptosis induction was assessed by exposure to phosphatidylserine (ANNEXIN V-FITC).	Phosphatidylserines	52-70	annexin A5	Mus musculus	72-81
20677810-9	2010	Upon Rs1 adsorption, these PS and PS-containing mixed bilayers underwent fast and extensive reorganization.	Phosphatidylserines	27-29	retinoschisis (X-linked, juvenile) 1 (human)	Mus musculus	5-8
20677810-9	2010	Upon Rs1 adsorption, these PS and PS-containing mixed bilayers underwent fast and extensive reorganization.	Phosphatidylserines	34-36	retinoschisis (X-linked, juvenile) 1 (human)	Mus musculus	5-8
20457869-5	2010	Phosphatidylserine (PS) exposure was similarly decreased in response to thrombin, CRP, or CRP + PAR4 peptide despite a normal platelet phospholipid composition.	Phosphatidylserines	0-18	coagulation factor II, thrombin	Homo sapiens	72-80
20457869-5	2010	Phosphatidylserine (PS) exposure was similarly decreased in response to thrombin, CRP, or CRP + PAR4 peptide despite a normal platelet phospholipid composition.	Phosphatidylserines	0-18	C-reactive protein	Homo sapiens	82-85
20457869-5	2010	Phosphatidylserine (PS) exposure was similarly decreased in response to thrombin, CRP, or CRP + PAR4 peptide despite a normal platelet phospholipid composition.	Phosphatidylserines	0-18	C-reactive protein	Homo sapiens	90-93
20457869-5	2010	Phosphatidylserine (PS) exposure was similarly decreased in response to thrombin, CRP, or CRP + PAR4 peptide despite a normal platelet phospholipid composition.	Phosphatidylserines	0-18	Prader Willi/Angelman region RNA 4	Homo sapiens	96-100
20457869-5	2010	Phosphatidylserine (PS) exposure was similarly decreased in response to thrombin, CRP, or CRP + PAR4 peptide despite a normal platelet phospholipid composition.	Phosphatidylserines	20-22	coagulation factor II, thrombin	Homo sapiens	72-80
20457869-5	2010	Phosphatidylserine (PS) exposure was similarly decreased in response to thrombin, CRP, or CRP + PAR4 peptide despite a normal platelet phospholipid composition.	Phosphatidylserines	20-22	C-reactive protein	Homo sapiens	82-85
20457869-5	2010	Phosphatidylserine (PS) exposure was similarly decreased in response to thrombin, CRP, or CRP + PAR4 peptide despite a normal platelet phospholipid composition.	Phosphatidylserines	20-22	C-reactive protein	Homo sapiens	90-93
20457869-5	2010	Phosphatidylserine (PS) exposure was similarly decreased in response to thrombin, CRP, or CRP + PAR4 peptide despite a normal platelet phospholipid composition.	Phosphatidylserines	20-22	Prader Willi/Angelman region RNA 4	Homo sapiens	96-100
20495145-7	2010	An intracellular Ca(2+) increase and the resultant activation of Ca(2+)-dependent PKC-alpha appeared to underlie the PA-induced PS exposure through the activation of scramblase.	Phosphatidylserines	128-130	protein kinase C alpha	Homo sapiens	82-91
20516018-3	2010	Externalization of PS during cell activation is mediated by phospholipid scramblase 1 (PLSCR1) and has a central role in promoting blood coagulation.	Phosphatidylserines	19-21	phospholipid scramblase 1	Homo sapiens	60-85
20516018-3	2010	Externalization of PS during cell activation is mediated by phospholipid scramblase 1 (PLSCR1) and has a central role in promoting blood coagulation.	Phosphatidylserines	19-21	phospholipid scramblase 1	Homo sapiens	87-93
20516018-10	2010	PS exposure on CD14+ cell surface was analyzed by flow cytometry.	Phosphatidylserines	0-2	CD14 molecule	Homo sapiens	15-19
20516018-13	2010	Flow-cytometry analysis showed relative enhancement of PS exposure in the surface of CD14+ cells in SLE patients compared to healthy controls.	Phosphatidylserines	55-57	CD14 molecule	Homo sapiens	85-89
20516018-15	2010	Monocytes in SLE patients had enhanced PLSCR1 mRNA expression, as well as increased fibrin turnover and cell-surface PS exposure, indicating that PLSCR1 may, in part, contribute to the prothrombotic tendency in SLE.	Phosphatidylserines	117-119	phospholipid scramblase 1	Homo sapiens	146-152
20519511-11	2010	These data show for the first time that: (i) STIM1 and Orai1 jointly contribute to GPVI-induced SOCE, procoagulant activity, and thrombus formation; (ii) a compensating Ca(2+) entry pathway is effective in the additional presence of thrombin; (iii) platelets contain two mechanisms of Ca(2+) entry and PS exposure, only one relying on STIM1-Orai1 interaction.	Phosphatidylserines	302-304	stromal interaction molecule 1	Mus musculus	45-50
20519511-11	2010	These data show for the first time that: (i) STIM1 and Orai1 jointly contribute to GPVI-induced SOCE, procoagulant activity, and thrombus formation; (ii) a compensating Ca(2+) entry pathway is effective in the additional presence of thrombin; (iii) platelets contain two mechanisms of Ca(2+) entry and PS exposure, only one relying on STIM1-Orai1 interaction.	Phosphatidylserines	302-304	glycoprotein 6 (platelet)	Mus musculus	83-87
20566714-5	2010	The Ig-like domain of LMIR5 bound to TIM1 in the vicinity of the phosphatidylserine (PS)-binding site within the Ig-like domain of TIM1.	Phosphatidylserines	65-83	CD300 molecule like family member B	Mus musculus	22-27
20566714-5	2010	The Ig-like domain of LMIR5 bound to TIM1 in the vicinity of the phosphatidylserine (PS)-binding site within the Ig-like domain of TIM1.	Phosphatidylserines	65-83	hepatitis A virus cellular receptor 1	Mus musculus	37-41
20566714-5	2010	The Ig-like domain of LMIR5 bound to TIM1 in the vicinity of the phosphatidylserine (PS)-binding site within the Ig-like domain of TIM1.	Phosphatidylserines	65-83	hepatitis A virus cellular receptor 1	Mus musculus	131-135
20566714-5	2010	The Ig-like domain of LMIR5 bound to TIM1 in the vicinity of the phosphatidylserine (PS)-binding site within the Ig-like domain of TIM1.	Phosphatidylserines	85-87	CD300 molecule like family member B	Mus musculus	22-27
20566714-5	2010	The Ig-like domain of LMIR5 bound to TIM1 in the vicinity of the phosphatidylserine (PS)-binding site within the Ig-like domain of TIM1.	Phosphatidylserines	85-87	hepatitis A virus cellular receptor 1	Mus musculus	37-41
20566714-5	2010	The Ig-like domain of LMIR5 bound to TIM1 in the vicinity of the phosphatidylserine (PS)-binding site within the Ig-like domain of TIM1.	Phosphatidylserines	85-87	hepatitis A virus cellular receptor 1	Mus musculus	131-135
20531278-5	2010	Membrane changes of the spermatozoa were investigated by staining with phycoerythrin (PE)-conjugated Annexin V, which detects exteriorization of phosphotidylserine from the inner to the outer leaflet of the sperm plasma membrane, and 7-aminoactinomycin D (7-AAD), which binds to the sperm nucleus when the plasma membrane is damaged.	Phosphatidylserines	145-163	annexin A5	Mus musculus	101-110
20382256-6	2010	The PS binding activity of stabilin-2 is enhanced in low pH, and a conserved histidine(1403) in close proximity to the PS binding loop is critical for pH-dependent activity.	Phosphatidylserines	4-6	stabilin 2	Homo sapiens	27-37
20179319-2	2010	Of all lipid-binding proteins tested, only NPC2 transferred cholesterol at a substantial rate, with no transfer of ceramide, GM3, galactosylceramide, sulfatide, phosphatidylethanolamine, or phosphatidylserine.	Phosphatidylserines	190-208	NPC intracellular cholesterol transporter 2	Homo sapiens	43-47
20400181-0	2010	Interaction of hypochlorous acid and myeloperoxidase with phosphatidylserine in the presence of ammonium ions.	Phosphatidylserines	58-76	myeloperoxidase	Homo sapiens	37-52
20388711-11	2010	Moreover, LOE-908, which blocks 1-oleoyl-2-acetyl-sn-glycerol-induced Ca(2+) entry but not store-operated Ca(2+) entry, blocked the enhanced GPVI-dependent Ca(2+) signaling and PS exposure seen in PKCtheta(-/-) platelets.	Phosphatidylserines	177-179	glycoprotein VI platelet	Homo sapiens	141-145
20452604-4	2010	We selected the specific detection approach by neutral loss survey-dependent MS3, for the identification of molecular species of phosphatidylcholine, sphingomyelin and phosphatidylserine.	Phosphatidylserines	168-186	minisatellites detected by probe MMS3	Mus musculus	77-80
20345632-6	2010	*On lipid and acyl-CoA analyses, the siliques, but not the leaves, of the acbp1 mutant accumulated galactolipid monogalactosyldiacylglycerol and 18:0-CoA, but the levels of most polyunsaturated species of phospholipid, such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol and phosphatidylserine, declined.	Phosphatidylserines	299-317	acyl-CoA binding protein 1	Arabidopsis thaliana	74-79
20352156-2	2010	Persistence of PS exposure may be attributed, at least in part, to a continued reduction of the activity of aminophospholipid translocase (APLT), that transports PS from the outer to the inner membrane leaflet.	Phosphatidylserines	15-17	ATPase phospholipid transporting 8A1	Homo sapiens	108-137
20352156-2	2010	Persistence of PS exposure may be attributed, at least in part, to a continued reduction of the activity of aminophospholipid translocase (APLT), that transports PS from the outer to the inner membrane leaflet.	Phosphatidylserines	15-17	ATPase phospholipid transporting 8A1	Homo sapiens	139-143
20352156-2	2010	Persistence of PS exposure may be attributed, at least in part, to a continued reduction of the activity of aminophospholipid translocase (APLT), that transports PS from the outer to the inner membrane leaflet.	Phosphatidylserines	162-164	ATPase phospholipid transporting 8A1	Homo sapiens	108-137
20352156-2	2010	Persistence of PS exposure may be attributed, at least in part, to a continued reduction of the activity of aminophospholipid translocase (APLT), that transports PS from the outer to the inner membrane leaflet.	Phosphatidylserines	162-164	ATPase phospholipid transporting 8A1	Homo sapiens	139-143
20520724-7	2010	Interestingly, the level of COMT enzyme activity was inversely correlated with the cells" ability to synthesize phosphatidylserine (PS), a factor that attracts the pleckstrin homology domain (PHD) of AKT1 to the cell membrane.	Phosphatidylserines	112-130	catechol-O-methyltransferase	Homo sapiens	28-32
20520724-7	2010	Interestingly, the level of COMT enzyme activity was inversely correlated with the cells" ability to synthesize phosphatidylserine (PS), a factor that attracts the pleckstrin homology domain (PHD) of AKT1 to the cell membrane.	Phosphatidylserines	112-130	AKT serine/threonine kinase 1	Homo sapiens	200-204
20520724-7	2010	Interestingly, the level of COMT enzyme activity was inversely correlated with the cells" ability to synthesize phosphatidylserine (PS), a factor that attracts the pleckstrin homology domain (PHD) of AKT1 to the cell membrane.	Phosphatidylserines	132-134	catechol-O-methyltransferase	Homo sapiens	28-32
20520724-7	2010	Interestingly, the level of COMT enzyme activity was inversely correlated with the cells" ability to synthesize phosphatidylserine (PS), a factor that attracts the pleckstrin homology domain (PHD) of AKT1 to the cell membrane.	Phosphatidylserines	132-134	AKT serine/threonine kinase 1	Homo sapiens	200-204
20520724-8	2010	Transfection of SH-SY5Y cells with a COMT Val construct increased COMT activity and significantly decreased PS levels as well as NRG1-induced AKT1 phosphorylation and migration.	Phosphatidylserines	108-110	catechol-O-methyltransferase	Homo sapiens	37-41
20520724-8	2010	Transfection of SH-SY5Y cells with a COMT Val construct increased COMT activity and significantly decreased PS levels as well as NRG1-induced AKT1 phosphorylation and migration.	Phosphatidylserines	108-110	catechol-O-methyltransferase	Homo sapiens	66-70
20520724-10	2010	These data suggest that AKT1 function is influenced by COMT enzyme activity through competition with PS synthesis for SAM, which in turn dictates AKT1-dependent cellular responses to NRG1-mediated signaling.	Phosphatidylserines	101-103	AKT serine/threonine kinase 1	Homo sapiens	24-28
20520724-10	2010	These data suggest that AKT1 function is influenced by COMT enzyme activity through competition with PS synthesis for SAM, which in turn dictates AKT1-dependent cellular responses to NRG1-mediated signaling.	Phosphatidylserines	101-103	catechol-O-methyltransferase	Homo sapiens	55-59
20520724-10	2010	These data suggest that AKT1 function is influenced by COMT enzyme activity through competition with PS synthesis for SAM, which in turn dictates AKT1-dependent cellular responses to NRG1-mediated signaling.	Phosphatidylserines	101-103	AKT serine/threonine kinase 1	Homo sapiens	146-150
20520724-10	2010	These data suggest that AKT1 function is influenced by COMT enzyme activity through competition with PS synthesis for SAM, which in turn dictates AKT1-dependent cellular responses to NRG1-mediated signaling.	Phosphatidylserines	101-103	neuregulin 1	Homo sapiens	183-187
20402461-1	2010	The induction of apoptosis is frequently accompanied by the exposure of phosphatidylserine (PS) on the cell surface, which has been detected using radionuclide and fluorescently labeled derivatives of the PS-binding protein, Annexin V.	Phosphatidylserines	72-90	annexin A5	Homo sapiens	225-234
20402461-1	2010	The induction of apoptosis is frequently accompanied by the exposure of phosphatidylserine (PS) on the cell surface, which has been detected using radionuclide and fluorescently labeled derivatives of the PS-binding protein, Annexin V.	Phosphatidylserines	92-94	annexin A5	Homo sapiens	225-234
20231275-10	2010	In conclusion, this study shows that HlyA triggers acute erythrocyte shrinkage, which depends on Ca(2+)-activated efflux of K(+) via K(Ca)3.1 and Cl(-) via TMEM16A, with subsequent phosphatidylserine exposure.	Phosphatidylserines	181-199	hemolysin transport protein	Escherichia coli	37-41
20231275-10	2010	In conclusion, this study shows that HlyA triggers acute erythrocyte shrinkage, which depends on Ca(2+)-activated efflux of K(+) via K(Ca)3.1 and Cl(-) via TMEM16A, with subsequent phosphatidylserine exposure.	Phosphatidylserines	181-199	anoctamin 1, calcium activated chloride channel	Mus musculus	156-163
20206382-3	2010	PS was incorporated into microspheres composed of the copolymers of lactide and glycolide (PLG) using an emulsion process.	Phosphatidylserines	0-2	plasminogen	Homo sapiens	91-94
20206382-4	2010	Increasing the weight ratio of PS to PLG led to a greater incorporation of PS.	Phosphatidylserines	75-77	plasminogen	Homo sapiens	37-40
20193962-4	2010	Lateral segregations of CL and PS were observed through the fluorescence properties of fluorophore-labeled phospholipids upon BI-1 reconstitution in PC/CL or PC/PS binary systems.	Phosphatidylserines	31-33	transmembrane BAX inhibitor motif containing 6	Homo sapiens	126-130
20193962-8	2010	Furthermore, the CL, PS, and BH4 domains specifically increased oligomerization levels such as dimer and tetramer of BI-1 in membranes.	Phosphatidylserines	21-23	transmembrane BAX inhibitor motif containing 6	Homo sapiens	117-121
20095951-6	2010	Here we report that non-myristoylated GAPR-1 stably binds liposomes that contain the negatively charged lipids phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, or phosphatidic acid.	Phosphatidylserines	111-129	GLI pathogenesis related 2	Homo sapiens	38-44
20096634-1	2010	Magnetic activated cell sorting (MACS) with annexin V microbeads recognizes externalized phosphatidylserine (PS) residues on the surface of apoptotic spermatozoa.	Phosphatidylserines	89-107	annexin A5	Homo sapiens	44-53
20096634-1	2010	Magnetic activated cell sorting (MACS) with annexin V microbeads recognizes externalized phosphatidylserine (PS) residues on the surface of apoptotic spermatozoa.	Phosphatidylserines	109-111	annexin A5	Homo sapiens	44-53
21203987-2	2010	Here we present evidence that phosphatidylserine (PS) is a relevant binding molecule for human SP-A.	Phosphatidylserines	30-48	surfactant protein A1	Homo sapiens	95-99
21203987-2	2010	Here we present evidence that phosphatidylserine (PS) is a relevant binding molecule for human SP-A.	Phosphatidylserines	50-52	surfactant protein A1	Homo sapiens	95-99
21203987-6	2010	However, we cannot conclude that this inhibition is exclusively due to the binding of SP-A to PS on the cell surface, as annexin V is not wholly specific for PS and SP-A also interacts with other phospholipids that might become exposed on the apoptotic cell surface.	Phosphatidylserines	94-96	surfactant protein A1	Homo sapiens	86-90
19892706-10	2010	Instead, we show that Rpe65 binds the acidic phospholipids, phosphatidylserine, phosphatidylglycerol, and cardiolipin, but not phosphatidic acid.	Phosphatidylserines	60-78	retinoid isomerohydrolase RPE65	Homo sapiens	22-27
19892706-13	2010	Binding of Rpe65 to liposomes containing phosphatidylserine or phosphatidylglycerol, but not the basic or neutral phospholipids, allowed the enzyme to extract its insoluble substrate, all-trans-retinyl palmitate, from the lipid bilayer for synthesis of 11-cis-retinol.	Phosphatidylserines	41-59	retinoid isomerohydrolase RPE65	Homo sapiens	11-16
20637106-2	2010	Gas6 and protein S are ligands for these TAM kinases and bind to phosphatidyl serine residues exposed during apoptosis.	Phosphatidylserines	65-84	growth arrest specific 6	Homo sapiens	0-4
20637106-2	2010	Gas6 and protein S are ligands for these TAM kinases and bind to phosphatidyl serine residues exposed during apoptosis.	Phosphatidylserines	65-84	Myeloproliferative syndrome, transient (transient abnormal myelopoiesis)	Homo sapiens	41-44
19878624-5	2010	The C2A domain of synaptotagmin I, which binds PS with high affinity and specificity, was attached to the surface of mouse ESCs using the biotin-avidin coupling mechanism.	Phosphatidylserines	47-49	synaptotagmin I	Mus musculus	18-33
20798520-7	2010	Phosphatidylserine-exposing erythrocytes were identified by analysing annexin V-binding in FACS analysis.	Phosphatidylserines	0-18	annexin A5	Mus musculus	70-79
20061603-7	2010	The interaction of Abeta with cell membranes has previously been shown to be dependent on electrostatic interactions between Abeta and the negatively charged head group of phosphatidylserine.	Phosphatidylserines	172-190	amyloid beta precursor protein	Homo sapiens	19-24
20061603-7	2010	The interaction of Abeta with cell membranes has previously been shown to be dependent on electrostatic interactions between Abeta and the negatively charged head group of phosphatidylserine.	Phosphatidylserines	172-190	amyloid beta precursor protein	Homo sapiens	125-130
20122665-3	2010	Annexin-V (AnxV) has been shown to have high affinity to externalized phosphatidylserine.	Phosphatidylserines	70-88	annexin A5	Mus musculus	0-9
20122665-3	2010	Annexin-V (AnxV) has been shown to have high affinity to externalized phosphatidylserine.	Phosphatidylserines	70-88	annexin A5	Mus musculus	11-15
20641573-10	2004	On the other hand, PS is also accessible for annexin V binding in necrosis because of disruption of the plasma membrane.	Phosphatidylserines	19-21	annexin A5	Homo sapiens	45-54
20641573-12	2004	Annexin V binds to PS with high affinity (KD = 7 nM) (5, 9, 10).	Phosphatidylserines	19-21	annexin A5	Homo sapiens	0-9
19799864-2	2009	Annexin A5, an intracellular protein abundantly present in endothelial cells and platelets, exhibits high affinity for PS and has been shown to inhibit several of these PS-mediated pathophysiological processes.	Phosphatidylserines	119-121	annexin A5	Homo sapiens	0-10
19799864-2	2009	Annexin A5, an intracellular protein abundantly present in endothelial cells and platelets, exhibits high affinity for PS and has been shown to inhibit several of these PS-mediated pathophysiological processes.	Phosphatidylserines	169-171	annexin A5	Homo sapiens	0-10
19828732-1	2009	The synaptic vesicle protein synaptotagmin I (Syt I) binds phosphatidylserine (PS) in a Ca(2+)-dependent manner.	Phosphatidylserines	59-77	synaptotagmin 1	Rattus norvegicus	46-51
19828732-1	2009	The synaptic vesicle protein synaptotagmin I (Syt I) binds phosphatidylserine (PS) in a Ca(2+)-dependent manner.	Phosphatidylserines	79-81	synaptotagmin 1	Rattus norvegicus	46-51
19828732-3	2009	To determine potential roles for Syt I-PS binding, we varied the PS content in PC12 cells and liposomes and studied the effects on the kinetics of exocytosis and Syt I binding in parallel.	Phosphatidylserines	39-41	synaptotagmin 1	Rattus norvegicus	33-38
19828732-5	2009	Ca(2+)-Syt I bound liposomes more tightly as PS content was raised, with a steep increase in binding at low PS, and a further gradual increase at higher PS.	Phosphatidylserines	45-47	synaptotagmin 1	Rattus norvegicus	7-12
19828732-6	2009	These two phases in the PS dependence of Ca(2+)-dependent Syt I binding to lipid may correspond to the two distinct and opposing kinetic effects of PS on exocytosis.	Phosphatidylserines	24-26	synaptotagmin 1	Rattus norvegicus	58-63
19779967-3	2009	Contrary to other AnnexinA5 variants, the new cys-AnxA5 allows for site-specific conjugation of a hydrazinonicotinamide-maleimide moiety and subsequent radio-labeling with (99m)Tc at a position not involved in the AnxA5-phosphatidylserine interaction.	Phosphatidylserines	220-238	annexin A5	Rattus norvegicus	50-55
19778899-5	2009	Atp8a2 purified from photoreceptor outer segments by immunoaffinity chromatography exhibited ATPase activity that was stimulated by phosphatidylserine and to a lesser degree phosphatidylethanolamine but not by phosphatidylcholine or other membrane lipids.	Phosphatidylserines	132-150	ATPase phospholipid transporting 8A2	Homo sapiens	0-6
19778899-7	2009	Fluorescence measurements showed that Atp8a2 flipped fluorescent-labeled phosphatidylserine from the inner leaflet of liposomes (equivalent to the exocytoplasmic leaflet of cell membranes) to the outer leaflet (equivalent to cytoplasmic leaflet) in an ATP-dependent manner.	Phosphatidylserines	73-91	ATPase phospholipid transporting 8A2	Homo sapiens	38-44
19663786-5	2009	Key steps that occur during apoptosis have already been evaluated; among these are the externalisation of phospholipid phosphatidylserine to the outer leaflet of the cell membrane, which can be visualized by labeled annexin A5 and the activation of caspases, especially effector caspase-3, which can be addressed by labeled enzyme substrates or synthetic caspase inhibitors.	Phosphatidylserines	119-137	annexin A5	Homo sapiens	216-226
19663786-5	2009	Key steps that occur during apoptosis have already been evaluated; among these are the externalisation of phospholipid phosphatidylserine to the outer leaflet of the cell membrane, which can be visualized by labeled annexin A5 and the activation of caspases, especially effector caspase-3, which can be addressed by labeled enzyme substrates or synthetic caspase inhibitors.	Phosphatidylserines	119-137	caspase 3	Homo sapiens	279-288
19696403-4	2009	CsA inhibited PS exposure, [Ca(2+)](cyt) increase, and DeltaPsim loss in platelets stimulated with TG and Thr/Cvx, but had no inhibitory effect on A23187 stimulation.	Phosphatidylserines	14-16	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	0-3
19835411-2	2009	We present here the synthesis and physicochemical characterization of liposomes containing PEGylated lipids covalently linked to oriented Annexin-A5 (Anx5) proteins, and we show that Anx5-functionalized liposomes are able to target phosphatidylserine (PS)-exposing membranes.	Phosphatidylserines	252-254	annexin A5	Homo sapiens	150-154
19835411-2	2009	We present here the synthesis and physicochemical characterization of liposomes containing PEGylated lipids covalently linked to oriented Annexin-A5 (Anx5) proteins, and we show that Anx5-functionalized liposomes are able to target phosphatidylserine (PS)-exposing membranes.	Phosphatidylserines	232-250	annexin A5	Homo sapiens	138-148
19835411-2	2009	We present here the synthesis and physicochemical characterization of liposomes containing PEGylated lipids covalently linked to oriented Annexin-A5 (Anx5) proteins, and we show that Anx5-functionalized liposomes are able to target phosphatidylserine (PS)-exposing membranes.	Phosphatidylserines	232-250	annexin A5	Homo sapiens	150-154
19835411-2	2009	We present here the synthesis and physicochemical characterization of liposomes containing PEGylated lipids covalently linked to oriented Annexin-A5 (Anx5) proteins, and we show that Anx5-functionalized liposomes are able to target phosphatidylserine (PS)-exposing membranes.	Phosphatidylserines	232-250	annexin A5	Homo sapiens	183-187
19835411-2	2009	We present here the synthesis and physicochemical characterization of liposomes containing PEGylated lipids covalently linked to oriented Annexin-A5 (Anx5) proteins, and we show that Anx5-functionalized liposomes are able to target phosphatidylserine (PS)-exposing membranes.	Phosphatidylserines	252-254	annexin A5	Homo sapiens	183-187
19835411-5	2009	Anx5-functionalized liposomes bind PS-containing membranes with very high efficacy, which is mainly due to the controlled orientation of the Anx5 at the liposome surface.	Phosphatidylserines	35-37	annexin A5	Homo sapiens	0-4
19835411-5	2009	Anx5-functionalized liposomes bind PS-containing membranes with very high efficacy, which is mainly due to the controlled orientation of the Anx5 at the liposome surface.	Phosphatidylserines	35-37	annexin A5	Homo sapiens	141-145
19835411-6	2009	A striking result, obtained by quartz crystal microbalance with dissipation monitoring, is that one single Anx5 molecule is able to anchor a liposome to a PS-containing supported membrane.	Phosphatidylserines	155-157	annexin A5	Homo sapiens	107-111
19835411-7	2009	Finally, we show by fluorescence microscopy that Anx5-functionalized liposomes bind PS-exposing apoptotic K562 cells with high specificity.	Phosphatidylserines	84-86	annexin A5	Homo sapiens	49-53
19454128-5	2009	Also an inverse correlation was observed between the C-reactive protein and membrane phosphatidylcholine and phosphatidylserine 20 : 4n-6.	Phosphatidylserines	109-127	C-reactive protein	Homo sapiens	53-71
19675564-2	2009	Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion.	Phosphatidylserines	65-83	interleukin 1 beta	Homo sapiens	209-213
19675564-2	2009	Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion.	Phosphatidylserines	65-83	interleukin 6	Homo sapiens	215-218
19675564-2	2009	Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion.	Phosphatidylserines	65-83	C-C motif chemokine ligand 2	Homo sapiens	220-224
19675564-2	2009	Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion.	Phosphatidylserines	65-83	C-C motif chemokine ligand 5	Homo sapiens	226-230
19675564-2	2009	Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion.	Phosphatidylserines	65-83	C-X-C motif chemokine ligand 10	Homo sapiens	232-238
19675564-2	2009	Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion.	Phosphatidylserines	65-83	intercellular adhesion molecule 1	Homo sapiens	244-249
19675564-2	2009	Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion.	Phosphatidylserines	85-87	interleukin 1 beta	Homo sapiens	209-213
19675564-2	2009	Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion.	Phosphatidylserines	85-87	interleukin 6	Homo sapiens	215-218
19675564-2	2009	Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion.	Phosphatidylserines	85-87	C-C motif chemokine ligand 2	Homo sapiens	220-224
19675564-2	2009	Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion.	Phosphatidylserines	85-87	C-C motif chemokine ligand 5	Homo sapiens	226-230
19675564-2	2009	Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion.	Phosphatidylserines	85-87	C-X-C motif chemokine ligand 10	Homo sapiens	232-238
19675564-2	2009	Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion.	Phosphatidylserines	85-87	intercellular adhesion molecule 1	Homo sapiens	244-249
19843455-0	2009	Factor XA binding to phosphatidylserine-containing membranes produces an inactive membrane-bound dimer.	Phosphatidylserines	21-39	coagulation factor X	Homo sapiens	0-9
19843455-4	2009	However, soluble, short-chain PS also triggers efficient proteolytic activity and formation of an inactive FXa dimer in solution.	Phosphatidylserines	30-32	coagulation factor X	Homo sapiens	107-110
19843455-5	2009	In this work, we ask whether PS-containing membranes also trigger formation of an inactive FXa dimer.	Phosphatidylserines	29-31	coagulation factor X	Homo sapiens	91-94
19531362-6	2009	In this method, PS is first bound to fluorescent annexin V, and then the residual nonbound annexin is quantified by binding to PS exposed on apoptotic cells.	Phosphatidylserines	16-18	annexin A5	Homo sapiens	49-58
19546474-6	2009	Both lactadherin and annexin V staining revealed PS localized to plasma membrane rim and blebs.	Phosphatidylserines	49-51	annexin A5	Homo sapiens	21-30
19546474-8	2009	All in all, the data further delineate the differences in PS binding patterns of lactadherin and annexin V.	Phosphatidylserines	58-60	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	81-92
19546474-8	2009	All in all, the data further delineate the differences in PS binding patterns of lactadherin and annexin V.	Phosphatidylserines	58-60	annexin A5	Homo sapiens	97-106
19699526-11	2009	By these properties, the DCs may be protected against Gal-3 induced phosphatidylserine (PS) exposure and/or apoptosis.	Phosphatidylserines	68-86	galectin 3	Homo sapiens	54-59
19699526-11	2009	By these properties, the DCs may be protected against Gal-3 induced phosphatidylserine (PS) exposure and/or apoptosis.	Phosphatidylserines	88-90	galectin 3	Homo sapiens	54-59
19538542-6	2009	The role of RBC surface PS in stRBC/EC interaction was confirmed by the suppression of adhesion after the blocking of the stRBC surface PS with annexin V.	Phosphatidylserines	24-26	annexin A5	Homo sapiens	144-153
19538542-6	2009	The role of RBC surface PS in stRBC/EC interaction was confirmed by the suppression of adhesion after the blocking of the stRBC surface PS with annexin V.	Phosphatidylserines	136-138	annexin A5	Homo sapiens	144-153
20641445-3	2004	On the other hand, PS is also accessible for annexin V binding in necrosis because of disruption of the plasma membrane.	Phosphatidylserines	19-21	annexin A5	Rattus norvegicus	45-54
20641445-5	2004	Annexin V binds to PS with high affinity (Kd = 7 nM) (3, 7, 8).	Phosphatidylserines	19-21	annexin A5	Rattus norvegicus	0-9
20641632-3	2004	On the other hand, PS is also accessible for annexin V binding in necrosis because of disruption of the plasma membrane.	Phosphatidylserines	19-21	annexin A5	Homo sapiens	45-54
20641632-5	2004	Annexin V binds to PS with high affinity (Kd = 7 nM) (3, 7, 8).	Phosphatidylserines	19-21	annexin A5	Homo sapiens	0-9
19805341-7	2009	In proteoliposomes containing Drs2p, a phosphatidylserine analogue was actively flipped across the liposome bilayer to the outer leaflet in the presence of Mg(2+)-ATP, whereas no activity toward the phosphatidylcholine or sphingomyelin analogues was observed.	Phosphatidylserines	39-57	aminophospholipid-translocating P4-type ATPase DRS2	Saccharomyces cerevisiae S288C	30-35
19726632-10	2009	Thus, our results demonstrate that stabilin-1, found on alternatively activated macrophages, is a phagocytic receptor mediating the clearance of apoptotic cells in a PS-dependent manner.	Phosphatidylserines	166-168	stabilin 1	Mus musculus	35-45
19559673-8	2009	CD47 became clustered on apoptotic thymocytes, both co-localized with or separated from, clustered PS and cholesterol-rich GM-1 domains.	Phosphatidylserines	99-101	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	Mus musculus	0-4
19687221-1	2009	Annexin V is a ubiquitous intracellular protein in humans that has a variety of intriguing characteristics, including a nanomolar affinity for the membrane-bound constitutive anionic phospholipid known as phosphatidylserine (PS).	Phosphatidylserines	205-223	annexin A5	Homo sapiens	0-9
19549270-2	2009	Aminophospholipid translocase (APLT) returns externalized PS to the inner membrane, and phospholipid scramblase (PLSCR) equilibrates phospholipids (PL) across the membrane.	Phosphatidylserines	58-60	ATPase phospholipid transporting 8A1	Homo sapiens	0-29
19549270-2	2009	Aminophospholipid translocase (APLT) returns externalized PS to the inner membrane, and phospholipid scramblase (PLSCR) equilibrates phospholipids (PL) across the membrane.	Phosphatidylserines	58-60	ATPase phospholipid transporting 8A1	Homo sapiens	31-35
19289606-4	2009	Moreover, the interaction of Hsp70 with PS was demonstrated in artificial unilamellar phosphatidylcholine/ phosphatidylserine (PC/PS) liposomes at the physiological ratio of 8/2.	Phosphatidylserines	40-42	heat shock protein family A (Hsp70) member 4	Homo sapiens	29-34
19289606-4	2009	Moreover, the interaction of Hsp70 with PS was demonstrated in artificial unilamellar phosphatidylcholine/ phosphatidylserine (PC/PS) liposomes at the physiological ratio of 8/2.	Phosphatidylserines	107-125	heat shock protein family A (Hsp70) member 4	Homo sapiens	29-34
19289606-4	2009	Moreover, the interaction of Hsp70 with PS was demonstrated in artificial unilamellar phosphatidylcholine/ phosphatidylserine (PC/PS) liposomes at the physiological ratio of 8/2.	Phosphatidylserines	130-132	heat shock protein family A (Hsp70) member 4	Homo sapiens	29-34
19289606-7	2009	The interaction of Hsp70 with surface PS significantly reduces clonogenic cell survival in normoxic (EC(50) of Hsp70=85 microg/ml) and hypoxic (EC(50) of Hsp70=55 microg/ml) tumor cells.	Phosphatidylserines	38-40	heat shock protein family A (Hsp70) member 4	Homo sapiens	19-24
19289606-7	2009	The interaction of Hsp70 with surface PS significantly reduces clonogenic cell survival in normoxic (EC(50) of Hsp70=85 microg/ml) and hypoxic (EC(50) of Hsp70=55 microg/ml) tumor cells.	Phosphatidylserines	38-40	heat shock protein family A (Hsp70) member 4	Homo sapiens	111-116
19289606-7	2009	The interaction of Hsp70 with surface PS significantly reduces clonogenic cell survival in normoxic (EC(50) of Hsp70=85 microg/ml) and hypoxic (EC(50) of Hsp70=55 microg/ml) tumor cells.	Phosphatidylserines	38-40	heat shock protein family A (Hsp70) member 4	Homo sapiens	111-116
19502262-11	2009	Our study implicates that the impairment of phagocytic clearance of apoptotic cells through phosphotidylserine-dependent MFG-E8 system may lead to the development of human SLE.	Phosphatidylserines	92-110	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	121-127
19550036-5	2009	KChIP1 showed a higher binding capability with phosphatidylserine (PS) than truncated KChIP1.	Phosphatidylserines	47-65	potassium voltage-gated channel interacting protein 1	Homo sapiens	0-6
19550036-6	2009	Unlike that of truncated KChIP1, the binding of wild-type KChIP1 with membrane was enhanced by increasing the PS content.	Phosphatidylserines	110-112	potassium voltage-gated channel interacting protein 1	Homo sapiens	58-64
19550036-7	2009	Moreover, the binding of KChIP1 with phospholipid vesicles induced a change in the structure of KChIP1 in the presence of PS.	Phosphatidylserines	122-124	potassium voltage-gated channel interacting protein 1	Homo sapiens	25-31
19550036-7	2009	Moreover, the binding of KChIP1 with phospholipid vesicles induced a change in the structure of KChIP1 in the presence of PS.	Phosphatidylserines	122-124	potassium voltage-gated channel interacting protein 1	Homo sapiens	96-102
19550036-8	2009	Taken together, our data suggest that EF-hands 3 and 4 of KChIP1 are functionally involved in a specific association with PS on the membrane.	Phosphatidylserines	122-124	potassium voltage-gated channel interacting protein 1	Homo sapiens	58-64
19268649-4	2009	Pretreatment of platelets with cAMP-elevating agent, forskolin, abolished thrombin plus collagen-induced MP formation and PS exposure, and obviously decreased calcium ionophore-evoked MP shedding.	Phosphatidylserines	122-124	coagulation factor II, thrombin	Homo sapiens	74-82
19343718-6	2009	We therefore confirmed apoptosis using Annexin-V-FLUOS staining of phosphatidylserine exposed at the surface of apoptotic cells.	Phosphatidylserines	67-85	annexin A5	Homo sapiens	39-48
19242942-10	2009	Annexin V can be used to distinguish between wells containing PS groups previously incorporated in the membrane patches and reference wells without PS head groups.	Phosphatidylserines	62-64	annexin A5	Homo sapiens	0-9
19714900-0	2009	Specular neutron reflectivity studies of the interaction of cytochrome c with supported phosphatidylcholine bilayers doped with phosphatidylserine.	Phosphatidylserines	128-146	cytochrome c, somatic	Homo sapiens	60-72
19238135-5	2009	We found that CsA inhibited A23187-stimulated platelet apoptosis, completely preventing (i) depolarization of mitochondrial inner membrane potential (DeltaPsim), (ii) activation of cytosolic apoptosis executioner caspase-3, (iii) platelet shrinkage, and (iv) fragmentation of platelets to microparticles, but (v) only partially (approximately 25%), inhibiting phosphatidylserine (PS) exposure on the platelet surface.	Phosphatidylserines	360-378	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	14-17
19238135-5	2009	We found that CsA inhibited A23187-stimulated platelet apoptosis, completely preventing (i) depolarization of mitochondrial inner membrane potential (DeltaPsim), (ii) activation of cytosolic apoptosis executioner caspase-3, (iii) platelet shrinkage, and (iv) fragmentation of platelets to microparticles, but (v) only partially (approximately 25%), inhibiting phosphatidylserine (PS) exposure on the platelet surface.	Phosphatidylserines	360-378	caspase 3	Homo sapiens	213-222
19302798-2	2009	The second C2 domain of syt1, C2B, binds to membranes containing phosphatidylserine and phosphatidylcholine in a Ca2+-independent manner with a lipid partition coefficient of approximately 3.0 x 10(2) M(-1).	Phosphatidylserines	65-83	synaptotagmin 1	Homo sapiens	24-28
19302798-2	2009	The second C2 domain of syt1, C2B, binds to membranes containing phosphatidylserine and phosphatidylcholine in a Ca2+-independent manner with a lipid partition coefficient of approximately 3.0 x 10(2) M(-1).	Phosphatidylserines	65-83	secretoglobin family 2B member 3, pseudogene	Homo sapiens	30-33
19253956-4	2009	Dysferlin"s C2A domain was able to bind to phosphatidylserine (PS), phosphatidylinositol 4-phosphate [PtdIns(4)P], and phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P(2)] in a Ca(2+)-dependent fashion.	Phosphatidylserines	43-61	dysferlin	Homo sapiens	0-9
19253956-4	2009	Dysferlin"s C2A domain was able to bind to phosphatidylserine (PS), phosphatidylinositol 4-phosphate [PtdIns(4)P], and phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P(2)] in a Ca(2+)-dependent fashion.	Phosphatidylserines	63-65	dysferlin	Homo sapiens	0-9
19014349-1	2009	PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE (phosphatidylethanolamine) respectively into PS in intact cells.	Phosphatidylserines	0-2	phosphatidylserine synthase 1	Homo sapiens	97-101
19014349-1	2009	PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE (phosphatidylethanolamine) respectively into PS in intact cells.	Phosphatidylserines	0-2	phosphatidylserine synthase 1	Homo sapiens	103-116
19014349-1	2009	PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE (phosphatidylethanolamine) respectively into PS in intact cells.	Phosphatidylserines	0-2	phosphatidylserine synthase 2	Homo sapiens	122-126
19014349-5	2009	On the other hand, the purified PSS1 was shown to catalyse the conversion of both PC and PE into PS, although PSS1 in intact cells had been shown not to contribute to the conversion of PE into PS to a significant extent.	Phosphatidylserines	97-99	phosphatidylserine synthase 1	Homo sapiens	32-36
19014349-6	2009	Furthermore, we found that the purified PSS2, but not the purified PSS1, was inhibited on the addition of PS to the enzyme assay mixture, raising the possibility that there was some difference between the mechanisms of the inhibitory actions of PS towards PSS1 and PSS2.	Phosphatidylserines	40-42	phosphatidylserine synthase 1	Homo sapiens	256-260
19014349-6	2009	Furthermore, we found that the purified PSS2, but not the purified PSS1, was inhibited on the addition of PS to the enzyme assay mixture, raising the possibility that there was some difference between the mechanisms of the inhibitory actions of PS towards PSS1 and PSS2.	Phosphatidylserines	40-42	phosphatidylserine synthase 2	Homo sapiens	265-269
19076239-8	2009	Cnt5, so named because its closest human homolog is centaurin beta-5, binds to phosphatidic acid and phosphatidyl serine in vitro.	Phosphatidylserines	101-120	adaptor related protein complex 5 subunit beta 1	Homo sapiens	62-68
19122200-4	2009	A co-immunoprecipitation analysis showed the existence of a complex of GULP and SR-BI in cells prior to the activation of SR-BI by PS.	Phosphatidylserines	131-133	scavenger receptor class B member 1	Homo sapiens	122-127
19122200-6	2009	Administration to phagocytes of PS-containing liposomes increased the levels of the GTP-bound form of Rac1 and the phosphorylated forms of mitogen-activated protein kinases (MAPK) p38 and extracellular signal-related kinase 1 and 2.	Phosphatidylserines	32-34	Rac family small GTPase 1	Homo sapiens	102-106
19122200-6	2009	Administration to phagocytes of PS-containing liposomes increased the levels of the GTP-bound form of Rac1 and the phosphorylated forms of mitogen-activated protein kinases (MAPK) p38 and extracellular signal-related kinase 1 and 2.	Phosphatidylserines	32-34	mitogen-activated protein kinase 14	Homo sapiens	180-183
19122200-6	2009	Administration to phagocytes of PS-containing liposomes increased the levels of the GTP-bound form of Rac1 and the phosphorylated forms of mitogen-activated protein kinases (MAPK) p38 and extracellular signal-related kinase 1 and 2.	Phosphatidylserines	32-34	mitogen-activated protein kinase 3	Homo sapiens	188-231
18952895-0	2009	Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4.	Phosphatidylserines	94-112	interleukin 4	Mus musculus	137-141
18952895-8	2009	Finally, injection of PS (whose exposure is lacking on CGD apoptotic neutrophils) in vivo restored IL-4-dependent macrophage reprogramming and efferocytosis via a similar mechanism.	Phosphatidylserines	22-24	interleukin 4	Mus musculus	99-103
19103599-1	2009	Galectin-1 (Gal-1) regulates leukocyte turnover by inducing the cell surface exposure of phosphatidylserine (PS), a ligand that targets cells for phagocytic removal, in the absence of apoptosis.	Phosphatidylserines	89-107	galectin 1	Homo sapiens	0-10
19103599-1	2009	Galectin-1 (Gal-1) regulates leukocyte turnover by inducing the cell surface exposure of phosphatidylserine (PS), a ligand that targets cells for phagocytic removal, in the absence of apoptosis.	Phosphatidylserines	89-107	galectin 1	Homo sapiens	12-17
19103599-4	2009	A mutant form of Gal-1, containing C2S and V5D mutations (mGal-1), exhibits impaired dimerization and fails to induce cell surface PS exposure while retaining the ability to recognize carbohydrates and signal Ca(2+) flux in leukocytes.	Phosphatidylserines	131-133	galectin 1	Homo sapiens	17-22
19103599-6	2009	Continual incubation of leukocytes with Gal-1 resulted in gradual oxidative inactivation with concomitant loss of cell surface PS, whereas rapid oxidation prevented mGal-1 from inducing PS exposure.	Phosphatidylserines	127-129	galectin 1	Homo sapiens	40-45
19103599-8	2009	Alkylation-induced stabilization allowed Gal-1 to signal sustained PS exposure in leukocytes and mGal-1 to signal both Ca(2+) flux and PS exposure.	Phosphatidylserines	67-69	galectin 1	Homo sapiens	41-46
19103599-8	2009	Alkylation-induced stabilization allowed Gal-1 to signal sustained PS exposure in leukocytes and mGal-1 to signal both Ca(2+) flux and PS exposure.	Phosphatidylserines	135-137	galectin 1	Homo sapiens	41-46
19081240-1	2009	In this paper, we reported that a novel biosensor was developed to detect early apoptotic cells by the specific interaction between Annexin V and phosphatidylserine based on electrochemical impedance.	Phosphatidylserines	146-164	annexin A5	Homo sapiens	132-141
19059242-3	2009	Cytochrome c peroxidase activity and Trp59 fluorescence increase in the sequence of phosphatidyl choline (PC)--&gt;phosphatidylserine (PS)--&gt;cardiolipin (CL)--&gt;phosphatidic acid (PA).	Phosphatidylserines	115-133	cytochrome c, somatic	Homo sapiens	0-12
20641506-7	2004	Annexin V binds to PS with high affinity (dissociation constant (Kd) = 7 nM) (4), and duramycin binds to PE with a Kd value of 11 nM (6).	Phosphatidylserines	19-21	annexin A5	Rattus norvegicus	0-9
19910682-7	2009	In conclusion, PS exposure on erythrocytes results in accelerated clearance of Plasmodium ring stage-infected HbA/S or annexin-A7(-/-) erythrocytes and thus confers partial protection against malaria in vivo.	Phosphatidylserines	15-17	annexin A7	Mus musculus	119-129
19057200-4	2009	RECENT FINDINGS: BTHS neutrophils avidly expose phosphatidyl serine, a phospholipid that is normally restrained to the inner leaflet of the plasma membrane.	Phosphatidylserines	48-67	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	17-21
19689342-3	2009	Our novel understanding of the cellular and molecular mechanism of annexin A5 as a cell-entry agent and the finding that PS is expressed on living tumour as well as endothelial cells in the tumour vasculature, will allow the development of lead compounds for anti-cancer therapy.	Phosphatidylserines	121-123	annexin A5	Homo sapiens	67-77
19198650-4	2009	Macrophage uptake of PS-coated nanotubes was suppressed by the PS-binding protein, Annexin V, and endocytosis inhibitors, and changed the pattern of pro- and anti-inflammatory cytokine secretion.	Phosphatidylserines	21-23	annexin A5	Mus musculus	83-92
18951241-1	2009	OBJECTIVE: To investigate the early apoptosis that may be detected by Annexin V binding to phosphatidylserine and propidium iodide (PI) exclusion in human monocytes.	Phosphatidylserines	91-109	annexin A5	Homo sapiens	70-79
18954406-1	2009	BACKGROUND: Annexin V binding to platelets (PLTs) is considered the gold standard for monitoring phosphatidylserine (PS) exposure.	Phosphatidylserines	97-115	annexin A5	Homo sapiens	12-21
18954406-1	2009	BACKGROUND: Annexin V binding to platelets (PLTs) is considered the gold standard for monitoring phosphatidylserine (PS) exposure.	Phosphatidylserines	117-119	annexin A5	Homo sapiens	12-21
18954406-8	2009	However, a significantly higher percentage of PS-positive PLTs was found with lactadherin than annexin V.	Phosphatidylserines	46-48	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	78-89
18954406-8	2009	However, a significantly higher percentage of PS-positive PLTs was found with lactadherin than annexin V.	Phosphatidylserines	46-48	annexin A5	Homo sapiens	95-104
18954406-9	2009	CONCLUSION: PS exposure on the surface of stored PLTs has been previously underestimated due to the wide use of annexin V.	Phosphatidylserines	12-14	annexin A5	Homo sapiens	112-121
18954406-10	2009	Lactadherin provides a truer reflection of the degree of PS exposure and offers a new calcium-independent approach to studying PLT activation and/or apoptosis.	Phosphatidylserines	57-59	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	0-11
18829862-6	2008	Exogenously expressed sentan showed affinity for the membrane protrusions, and a protein-lipid binding assay revealed that sentan bound to phosphatidylserine.	Phosphatidylserines	139-157	sentan, cilia apical structure protein	Homo sapiens	22-28
18829862-6	2008	Exogenously expressed sentan showed affinity for the membrane protrusions, and a protein-lipid binding assay revealed that sentan bound to phosphatidylserine.	Phosphatidylserines	139-157	sentan, cilia apical structure protein	Homo sapiens	123-129
19132231-7	2008	SPR analyses indicated that soluble phosphatidylserine (1,2-Dicaproylsn-glycero-3-phospho-L-serine) competitively inhibited both FV-MMRN1 and FVa-MMRN1 binding.	Phosphatidylserines	36-54	multimerin 1	Homo sapiens	132-137
19132231-7	2008	SPR analyses indicated that soluble phosphatidylserine (1,2-Dicaproylsn-glycero-3-phospho-L-serine) competitively inhibited both FV-MMRN1 and FVa-MMRN1 binding.	Phosphatidylserines	36-54	multimerin 1	Homo sapiens	146-151
18680547-8	2008	Annexin V binding to phosphatidylserine was 50 +/- 9 percent and LDH was 496 +/- 207 IU per 10(12) PLTs.	Phosphatidylserines	21-39	annexin A5	Homo sapiens	0-9
18784085-2	2008	When protein S was added to phosphatidylcholine/phosphatidylserine (PC/PS, 4:1) vesicle-bound DEGR-fXa(i), the anisotropy of the dansyl moiety was altered from 0.219 +/- 0.002 to 0.245 +/- 0.003.	Phosphatidylserines	48-66	coagulation factor X	Homo sapiens	99-102
20641625-5	2004	PS is also accessible for annexin V (or annexin A5) binding in necrosis because of disruption of the plasma membrane.	Phosphatidylserines	0-2	annexin A5	Homo sapiens	26-35
20641625-5	2004	PS is also accessible for annexin V (or annexin A5) binding in necrosis because of disruption of the plasma membrane.	Phosphatidylserines	0-2	annexin A5	Homo sapiens	40-50
20641625-6	2004	Annexin V, a 36-kDa protein, binds to PS with high affinity (Kd = 7 nM).	Phosphatidylserines	38-40	annexin A5	Homo sapiens	0-9
18760998-4	2008	In support of this hypothesis are results showing that (1) two specific inhibitors of Gla-PS interactions, namely soluble PS and Annexin V, abrogate gas6-mediated endothelial cell survival and (2) Soluble PS inhibits Akt activation, a downstream intracellular event triggered by gas6-Axl binding.	Phosphatidylserines	90-92	growth arrest specific 6	Homo sapiens	149-153
18760998-4	2008	In support of this hypothesis are results showing that (1) two specific inhibitors of Gla-PS interactions, namely soluble PS and Annexin V, abrogate gas6-mediated endothelial cell survival and (2) Soluble PS inhibits Akt activation, a downstream intracellular event triggered by gas6-Axl binding.	Phosphatidylserines	122-124	growth arrest specific 6	Homo sapiens	149-153
18760998-5	2008	In conclusion, we propose a heretofore unknown function of Gla, where Gla-PS binding on the N-terminus of gas6 is necessary for a gas6 function mediated through its binding to Axl via its C-terminus.	Phosphatidylserines	74-76	growth arrest specific 6	Homo sapiens	106-110
18760998-5	2008	In conclusion, we propose a heretofore unknown function of Gla, where Gla-PS binding on the N-terminus of gas6 is necessary for a gas6 function mediated through its binding to Axl via its C-terminus.	Phosphatidylserines	74-76	growth arrest specific 6	Homo sapiens	130-134
18760998-5	2008	In conclusion, we propose a heretofore unknown function of Gla, where Gla-PS binding on the N-terminus of gas6 is necessary for a gas6 function mediated through its binding to Axl via its C-terminus.	Phosphatidylserines	74-76	AXL receptor tyrosine kinase	Homo sapiens	176-179
18829952-2	2008	During certain cellular processes, including apoptosis, PS translocates to the outer leaflet and can be labeled with externally applied annexin V, a calcium-dependent PS-binding protein.	Phosphatidylserines	56-58	annexin A5	Mus musculus	136-145
18841281-6	2008	GAS6 employs a unique mechanism of action, interacting through its vitamin K-dependent GLA (gamma-carboxyglutamic acid) module with phosphatidylserine-containing membranes and through its carboxy-terminal LamG domains with the TAM membrane receptors.	Phosphatidylserines	132-150	growth arrest specific 6	Homo sapiens	0-4
18940719-2	2008	Although TSP exhibits multiple cell-binding domains, the PS-binding site on TSP is unknown.	Phosphatidylserines	57-59	thrombospondin 1	Homo sapiens	76-79
18940719-10	2008	Our results demonstrate that PS-positive erythrocytes bind to both immobilized and soluble TSP via its heparin-binding domain and that both heparin and enoxaparin, at clinically relevant concentrations, block this interaction.	Phosphatidylserines	29-31	thrombospondin 1	Homo sapiens	91-94
18621733-4	2008	To systematically analyze how these lipids mediate PM targeting of cellular proteins, we performed biophysical, computational, and cell studies of the Ca(2+)-dependent C2 domain of protein kinase Calpha (PKCalpha) that is known to bind PS and phosphoinositides.	Phosphatidylserines	236-238	protein kinase C, alpha	Mus musculus	204-212
18621733-5	2008	In vitro membrane binding measurements by surface plasmon resonance analysis show that PKCalpha-C2 nonspecifically binds phosphoinositides, including PtdIns(4,5)P(2) and PtdIns(3,4,5)P(3), but that PS and Ca(2+) binding is prerequisite for productive phosphoinositide binding.	Phosphatidylserines	198-200	protein kinase C, alpha	Mus musculus	87-95
18621733-6	2008	PtdIns(4,5)P(2) or PtdIns(3,4,5)P(3) augments the Ca(2+)- and PS-dependent membrane binding of PKCalpha-C2 by slowing its membrane dissociation.	Phosphatidylserines	62-64	protein kinase C, alpha	Mus musculus	95-103
18621733-11	2008	Collectively, these studies show that PtdIns(4,5)P(2) and PtdIns(3,4,5)P(3) augment the Ca(2+)- and PS-dependent membrane binding of PKCalpha-C2 by elongating the membrane residence of the domain but cannot drive the PM recruitment of PKCalpha-C2.	Phosphatidylserines	100-102	protein kinase C, alpha	Mus musculus	133-141
18621733-11	2008	Collectively, these studies show that PtdIns(4,5)P(2) and PtdIns(3,4,5)P(3) augment the Ca(2+)- and PS-dependent membrane binding of PKCalpha-C2 by elongating the membrane residence of the domain but cannot drive the PM recruitment of PKCalpha-C2.	Phosphatidylserines	100-102	protein kinase C, alpha	Mus musculus	235-243
18794881-2	2008	Here, we discuss the concept of PTEN as an "interfacial enzyme", which exists in a high activity state when bound transiently at membrane surfaces containing its substrate and other acidic lipids, such as PtdIns(4,5)P(2) and phosphatidylserine (PtdSer).	Phosphatidylserines	225-243	phosphatase and tensin homolog	Mus musculus	32-36
18768881-6	2008	Phosphatidylserine (PS) is directly involved in the inhibition of phagocytosis by HMGB1, as blockade of HMGB1 by PS eliminates the effects of HMGB1 on efferocytosis.	Phosphatidylserines	0-18	high mobility group box 1	Mus musculus	82-87
18768881-6	2008	Phosphatidylserine (PS) is directly involved in the inhibition of phagocytosis by HMGB1, as blockade of HMGB1 by PS eliminates the effects of HMGB1 on efferocytosis.	Phosphatidylserines	0-18	high mobility group box 1	Mus musculus	104-109
18768881-6	2008	Phosphatidylserine (PS) is directly involved in the inhibition of phagocytosis by HMGB1, as blockade of HMGB1 by PS eliminates the effects of HMGB1 on efferocytosis.	Phosphatidylserines	0-18	high mobility group box 1	Mus musculus	104-109
18768881-6	2008	Phosphatidylserine (PS) is directly involved in the inhibition of phagocytosis by HMGB1, as blockade of HMGB1 by PS eliminates the effects of HMGB1 on efferocytosis.	Phosphatidylserines	20-22	high mobility group box 1	Mus musculus	82-87
18768881-6	2008	Phosphatidylserine (PS) is directly involved in the inhibition of phagocytosis by HMGB1, as blockade of HMGB1 by PS eliminates the effects of HMGB1 on efferocytosis.	Phosphatidylserines	20-22	high mobility group box 1	Mus musculus	104-109
18768881-6	2008	Phosphatidylserine (PS) is directly involved in the inhibition of phagocytosis by HMGB1, as blockade of HMGB1 by PS eliminates the effects of HMGB1 on efferocytosis.	Phosphatidylserines	20-22	high mobility group box 1	Mus musculus	104-109
18768881-6	2008	Phosphatidylserine (PS) is directly involved in the inhibition of phagocytosis by HMGB1, as blockade of HMGB1 by PS eliminates the effects of HMGB1 on efferocytosis.	Phosphatidylserines	113-115	high mobility group box 1	Mus musculus	104-109
18768881-6	2008	Phosphatidylserine (PS) is directly involved in the inhibition of phagocytosis by HMGB1, as blockade of HMGB1 by PS eliminates the effects of HMGB1 on efferocytosis.	Phosphatidylserines	113-115	high mobility group box 1	Mus musculus	104-109
18768881-7	2008	Confocal and fluorescence resonance energy transfer demonstrate that HMGB1 interacts with PS on the neutrophil surface.	Phosphatidylserines	90-92	high mobility group box 1	Mus musculus	69-74
18820763-11	2008	Lactadherin is more sensitive than annexin V for the detection of PS exposure as the physical structure of PS in these blebs and condensed apoptotic cell surface may be more conducive to binding lactadherin than annexin V.	Phosphatidylserines	66-68	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	0-11
18820763-11	2008	Lactadherin is more sensitive than annexin V for the detection of PS exposure as the physical structure of PS in these blebs and condensed apoptotic cell surface may be more conducive to binding lactadherin than annexin V.	Phosphatidylserines	66-68	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	195-206
18300296-4	2008	However, PS containing liposomal-rFVIII is likely to reduce the systemic exposure and efficacy of FVIII due to rapid uptake of the PS containing liposomes by the reticuloendothelial system (RES).	Phosphatidylserines	9-11	coagulation factor VIII	Homo sapiens	34-39
18300296-4	2008	However, PS containing liposomal-rFVIII is likely to reduce the systemic exposure and efficacy of FVIII due to rapid uptake of the PS containing liposomes by the reticuloendothelial system (RES).	Phosphatidylserines	131-133	coagulation factor VIII	Homo sapiens	34-39
18758661-1	2008	The protein kinase C (PKC) family consists of 13 members categorized as conventional or novel depending on whether diacylglycerol, calcium, or phosphatidylserine is required for activation.	Phosphatidylserines	143-161	protein kinase C alpha	Homo sapiens	22-25
18616222-2	2008	Installation of terminal functional groups (amine, thiol, or alkyne) onto the sn-2 chain provides reactive sites for bio-orthogonal conjugation of cargo with suitably protected PS derivatives.	Phosphatidylserines	177-179	solute carrier family 38 member 5	Homo sapiens	78-82
18610985-2	2008	Upon activation by cytoplasmic Ca (2+) ions, the C2 domain specifically binds to the plasma membrane inner leaflet where it recognizes the target lipids phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP 2).	Phosphatidylserines	153-171	prolactin induced protein	Homo sapiens	220-223
18610985-2	2008	Upon activation by cytoplasmic Ca (2+) ions, the C2 domain specifically binds to the plasma membrane inner leaflet where it recognizes the target lipids phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP 2).	Phosphatidylserines	173-175	prolactin induced protein	Homo sapiens	220-223
18610985-8	2008	In the absence of PIP 2, the polybasic lipid binding site on the beta3-beta4 hairpin is occupied with PS, but in the presence of PIP 2 this larger, higher affinity target lipid competitively displaces PS and causes the long axis of the domain to tilt 40 +/- 10 degrees toward the bilayer normal.	Phosphatidylserines	201-203	prolactin induced protein	Homo sapiens	129-132
18610985-9	2008	The ability of the beta3-beta4 hairpin site to bind PS as well as PIP 2 extends the lifetime of the membrane-docked state and is predicted to enhance the kinase turnover number of PKCalpha during a single membrane docking event.	Phosphatidylserines	52-54	protein kinase C alpha	Homo sapiens	180-188
18544538-3	2008	Here, we show that, in contrast to PE conjugation, the in vitro phosphatidylserine conjugation of Atg8 is markedly suppressed at physiological pH.	Phosphatidylserines	64-82	GABA type A receptor associated protein like 1	Homo sapiens	98-102
18627198-1	2008	Annexin V is useful in detecting apoptotic cells by binding to phosphatidylserine (PS) that is exposed on the outer surface of the cell membrane during apoptosis.	Phosphatidylserines	63-81	annexin A5	Homo sapiens	0-9
18627198-1	2008	Annexin V is useful in detecting apoptotic cells by binding to phosphatidylserine (PS) that is exposed on the outer surface of the cell membrane during apoptosis.	Phosphatidylserines	83-85	annexin A5	Homo sapiens	0-9
18782225-4	2008	In this study, we found that knockdown of another member of the MBOAT family in C. elegans, named mboa-6, reduced incorporation of exogenous PUFAs into phosphatidylcholine (PC), phosphatidylserine (PS) and phosphatidylethanolamine (PE) in C. elegans.	Phosphatidylserines	178-196	Lysophospholipid acyltransferase 5	Caenorhabditis elegans	98-104
18782225-4	2008	In this study, we found that knockdown of another member of the MBOAT family in C. elegans, named mboa-6, reduced incorporation of exogenous PUFAs into phosphatidylcholine (PC), phosphatidylserine (PS) and phosphatidylethanolamine (PE) in C. elegans.	Phosphatidylserines	198-200	Lysophospholipid acyltransferase 5	Caenorhabditis elegans	98-104
18340638-5	2008	According to annexin V binding, erythrocytes from patients indeed showed a significant increase of PS exposure within 1 week of treatment with azathioprine.	Phosphatidylserines	99-101	annexin A5	Homo sapiens	13-22
18508778-5	2008	Biochemical analysis revealed a strong correlation between the ability of syt isoforms to bind 1,2-dioleoyl phosphatidylserine (PS) and t-SNAREs in a Ca(2+)-promoted manner with their abilities to enhance fusion, further establishing PS and SNAREs as critical effectors for syt action.	Phosphatidylserines	128-130	synaptotagmin 1	Homo sapiens	74-77
18508778-5	2008	Biochemical analysis revealed a strong correlation between the ability of syt isoforms to bind 1,2-dioleoyl phosphatidylserine (PS) and t-SNAREs in a Ca(2+)-promoted manner with their abilities to enhance fusion, further establishing PS and SNAREs as critical effectors for syt action.	Phosphatidylserines	128-130	synaptotagmin 1	Homo sapiens	274-277
18469301-9	2008	The binding affinity of the GRP1 PH domain for PtdIns(3,4,5)P(3)-containing vesicles is further amplified (by approximately 6-fold) by nonspecific electrostatic interactions with phosphatidylserine/phosphatidylinositol.	Phosphatidylserines	179-197	cytohesin 3	Homo sapiens	28-32
18456665-12	2008	These results demonstrate that Gal-8 dimerization promotes functional bivalency of each CRD, which allows Gal-8 to signal PS exposure in leukocytes entirely through C-terminal domain recognition of polyLacNAc glycans.	Phosphatidylserines	122-124	galectin 8	Homo sapiens	31-36
18456665-12	2008	These results demonstrate that Gal-8 dimerization promotes functional bivalency of each CRD, which allows Gal-8 to signal PS exposure in leukocytes entirely through C-terminal domain recognition of polyLacNAc glycans.	Phosphatidylserines	122-124	galectin 8	Homo sapiens	106-111
18485093-4	2008	METHODS: Lactadherin, a PS-binding milk protein, was utilized together with annexin V to detect both partial and complete membrane PS exposure on platelets in a mouse model of thrombosis and to evaluate the functional need for PS.	Phosphatidylserines	24-26	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	9-20
18485093-4	2008	METHODS: Lactadherin, a PS-binding milk protein, was utilized together with annexin V to detect both partial and complete membrane PS exposure on platelets in a mouse model of thrombosis and to evaluate the functional need for PS.	Phosphatidylserines	131-133	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	9-20
18485093-6	2008	RESULTS: The number of lactadherin-binding sites on synthetic membranes was proportional to PS content, whereas annexin V required a threshold of 2.5-8% PS.	Phosphatidylserines	92-94	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	23-34
18485093-6	2008	RESULTS: The number of lactadherin-binding sites on synthetic membranes was proportional to PS content, whereas annexin V required a threshold of 2.5-8% PS.	Phosphatidylserines	153-155	annexin A5	Mus musculus	112-121
18485093-9	2008	In mice, blockade of PS with lactadherin inhibited platelet prothrombinase and factor Xase activity, and prolonged tail bleeding time and the time to carotid artery thrombosis.	Phosphatidylserines	21-23	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	29-40
18485093-9	2008	In mice, blockade of PS with lactadherin inhibited platelet prothrombinase and factor Xase activity, and prolonged tail bleeding time and the time to carotid artery thrombosis.	Phosphatidylserines	21-23	fibrinogen-like protein 2	Mus musculus	60-74
18522808-8	2008	Compared to wildtype littermate controls, hearts from Gpat1(-/-)(-/-) mice contained a lower amount of 16:0 in phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine/phosphatidylinositol and significantly more C20:4n6.	Phosphatidylserines	162-180	glycerol-3-phosphate acyltransferase, mitochondrial	Mus musculus	54-59
18337615-4	2008	The inhibitory effect on UV-induced MMP-1 expression was seen in NAPS, TAPS, LPA, PS, lysophosphatidylglycerol, and LPS.	Phosphatidylserines	67-69	matrix metallopeptidase 1	Homo sapiens	36-41
18337615-9	2008	In the aged skin, PS caused increased procollagen transcription and procollagen immunostaining in the upper dermis, and a significant decrease in MMP-1 expression at both mRNA and protein levels.	Phosphatidylserines	18-20	matrix metallopeptidase 1	Homo sapiens	146-151
18616866-8	2008	The results for Beta-1 power in the PS group were connected to a more relaxed state compared to the controls.	Phosphatidylserines	36-38	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	16-22
18619889-8	2008	In this paper, we describe our contribution to hematopoietic stem cells CD34+ study by flow cytometry before and after cryopreservation by using annexin V as a specific probe allowing detection of phosphatidyl serine, one of the major features of apoptosis.	Phosphatidylserines	197-216	CD34 molecule	Homo sapiens	72-76
18619889-8	2008	In this paper, we describe our contribution to hematopoietic stem cells CD34+ study by flow cytometry before and after cryopreservation by using annexin V as a specific probe allowing detection of phosphatidyl serine, one of the major features of apoptosis.	Phosphatidylserines	197-216	annexin A5	Homo sapiens	145-154
18435924-3	2008	We undertook an extended Cryo-electron microscopy study to follow the factor VIII binding to phosphatidylserine containing lipid nanotubes at different lipid composition.	Phosphatidylserines	93-111	cytochrome c oxidase subunit 8A	Homo sapiens	77-81
18343815-2	2008	PS is synthesized by two distinct base-exchange enzymes, PS synthase-1 (PSS1) and PS synthase-2 (PSS2), that are encoded by different genes.	Phosphatidylserines	0-2	phosphatidylserine synthase 1	Mus musculus	72-76
18343815-2	2008	PS is synthesized by two distinct base-exchange enzymes, PS synthase-1 (PSS1) and PS synthase-2 (PSS2), that are encoded by different genes.	Phosphatidylserines	0-2	phosphatidylserine synthase 2	Mus musculus	97-101
18443297-6	2008	The Ter119(+) cGKI-deficient splenocytes showed a marked increase in annexin V binding, pointing to phosphatidylserine (PS) exposure at the outer membrane leaflet, a hallmark of suicidal erythrocyte death or eryptosis.	Phosphatidylserines	100-118	protein kinase, cGMP-dependent, type I	Mus musculus	14-18
18443297-6	2008	The Ter119(+) cGKI-deficient splenocytes showed a marked increase in annexin V binding, pointing to phosphatidylserine (PS) exposure at the outer membrane leaflet, a hallmark of suicidal erythrocyte death or eryptosis.	Phosphatidylserines	120-122	protein kinase, cGMP-dependent, type I	Mus musculus	14-18
18443297-7	2008	Compared with control erythrocytes, cGKI-deficient erythrocytes exhibited in vitro a higher cytosolic Ca(2+) concentration, a known trigger of eryptosis, and showed increased PS exposure, which was paralleled by a faster clearance in vivo.	Phosphatidylserines	175-177	protein kinase, cGMP-dependent, type I	Mus musculus	36-40
18464157-6	2008	Phosphatidylserine-exposing platelets were present in thrombi of both vessel types, as detected with fluorescently labeled annexin A5.	Phosphatidylserines	0-18	annexin A5	Mus musculus	123-133
18378304-4	2008	In addition, we demonstrated that the recombinant StarD7 protein forms stable Gibbs and Langmuir monolayers at the air-buffer interface, showing marked surface activity and interaction with phospholipid monolayers, mainly with phosphatidylserine, cholesterol and phosphatidylglycerol.	Phosphatidylserines	227-245	StAR related lipid transfer domain containing 7	Homo sapiens	50-56
18436785-4	2008	In animals deficient in tat-1, PS is abnormally exposed on the cell surface, and normally living cells are randomly lost through a mechanism dependent on PSR-1, a PS-recognizing phagocyte receptor, and CED-1, which contributes to recognition and engulfment of apoptotic cells.	Phosphatidylserines	31-33	Phospholipid-transporting ATPase tat-1	Caenorhabditis elegans	24-29
18436785-5	2008	Thus, tat-1 appears to function in preventing appearance of PS in the outer leaflet of plasma membrane, and ectopic exposure of PS on the cell surface may result in removal of living cells by neighboring phagocytes.	Phosphatidylserines	60-62	Phospholipid-transporting ATPase tat-1	Caenorhabditis elegans	6-11
20641671-3	2004	On the other hand, PS is also accessible for annexin V binding in necrotic cells because of disruption of the plasma membrane.	Phosphatidylserines	19-21	annexin A5	Homo sapiens	45-54
20641671-5	2004	Annexin V binds to PS with high affinity (Kd = 7 nM) with 8 annexin V molecules per PS molecule (3, 7, 8).	Phosphatidylserines	19-21	annexin A5	Homo sapiens	0-9
20641671-5	2004	Annexin V binds to PS with high affinity (Kd = 7 nM) with 8 annexin V molecules per PS molecule (3, 7, 8).	Phosphatidylserines	19-21	annexin A5	Homo sapiens	60-69
20641674-18	2004	PS is also accessible for annexin V binding in necrosis because of disruption of the plasma membrane.	Phosphatidylserines	0-2	annexin A5	Mus musculus	26-35
20641674-19	2004	Annexin V binds to PS with high affinity (Kd = 7 nM).	Phosphatidylserines	19-21	annexin A5	Mus musculus	0-9
20641423-17	2004	PS is also accessible for annexin V binding in necrosis because of disruption of the plasma membrane.	Phosphatidylserines	0-2	annexin A5	Homo sapiens	26-35
20641423-18	2004	Annexin V binds to PS with high affinity (Kd = 7 nM).	Phosphatidylserines	19-21	annexin A5	Homo sapiens	0-9
20641449-3	2004	On the other hand, PS is also accessible for annexin V binding in necrosis because of disruption of the plasma membrane.	Phosphatidylserines	19-21	annexin A5	Homo sapiens	45-54
20641449-5	2004	Annexin V binds to PS with high affinity (Kd = 7 nM) with 8 annexin V molecules per PS (3, 7, 8).	Phosphatidylserines	19-21	annexin A5	Homo sapiens	0-9
20641449-5	2004	Annexin V binds to PS with high affinity (Kd = 7 nM) with 8 annexin V molecules per PS (3, 7, 8).	Phosphatidylserines	19-21	annexin A5	Homo sapiens	60-69
18187412-1	2008	The diacylglycerol (DG)/phorbol ester-dependent translocation of conventional protein kinase C (PKC) isozymes is mediated by the C1 domain, a membrane-targeting module that also selectively binds phosphatidylserine (PS).	Phosphatidylserines	196-214	protein kinase C beta	Homo sapiens	96-99
18174168-8	2008	The affinity of annexin V was the same regardless of the head group present on the anionic phospholipids tested (phosphatidylserine, phosphatidylglycerol, phosphatidylmethanol, and cardiolipin), ruling out specific interactions between the protein and non-phosphate moieties of the head group as a significant contributor to binding affinity.	Phosphatidylserines	113-131	annexin A5	Homo sapiens	16-25
18165900-8	2008	ARAP1 overexpressed in HEL cells does not affect their TRAIL-induced apoptosis or the membrane localization of DR4, but it enhances the cell-surface presentation of phosphatidyl serine.	Phosphatidylserines	165-184	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	Homo sapiens	0-5
18324365-3	2008	Annexin A5, a 35 kD plasma protein, has strong affinity for PS in the nano-molar range.	Phosphatidylserines	60-62	annexin A5	Homo sapiens	0-10
18324365-8	2008	In addition, it has been shown that Annexin A5 not only binds to exteriorized PS, but is also internalized through an Annexin A5 specific mechanism.	Phosphatidylserines	78-80	annexin A5	Homo sapiens	36-46
17993484-5	2008	The binding of peptides to membranes was confirmed by surface pressure (Langmuir film balance) measurements using phosphatidylcholine/phosphatidylserine monolayers, which show a significant increase after injection of rat annexin A1 N-terminal peptides.	Phosphatidylserines	134-152	annexin A1	Rattus norvegicus	222-232
17924964-4	2008	Moreover, the interaction of exposed PS with exogenously added annexin V perturbed PS-mediated cell signaling and transiently up-regulated the declining c-myb expression.	Phosphatidylserines	37-39	annexin A5	Mus musculus	63-72
17924964-4	2008	Moreover, the interaction of exposed PS with exogenously added annexin V perturbed PS-mediated cell signaling and transiently up-regulated the declining c-myb expression.	Phosphatidylserines	37-39	myeloblastosis oncogene	Mus musculus	153-158
17924964-4	2008	Moreover, the interaction of exposed PS with exogenously added annexin V perturbed PS-mediated cell signaling and transiently up-regulated the declining c-myb expression.	Phosphatidylserines	83-85	annexin A5	Mus musculus	63-72
17924964-5	2008	We, therefore, suggest that cell surface-exposed PS, which plays a role in the process of myotube formation, is also involved in the down-regulation of c-myb expression.	Phosphatidylserines	49-51	myeloblastosis oncogene	Mus musculus	152-157
18077822-5	2008	Colloidal superparamagnetic microbeads ( approximately 50 nm in diameter) conjugated with annexin V bind to PS and are used to separate dead and apoptotic spermatozoa by magnetic-activated cell sorting (MACS).	Phosphatidylserines	108-110	annexin A5	Homo sapiens	90-99
18077176-5	2008	Additionally, pro-apoptotic proteins Bax and caspase-3 have been implemented in the oxidative modification of PtdSer resulting in subsequent asymmetric collapse, while anti-apoptotic protein Bcl-2 has been found to prevent this process.	Phosphatidylserines	110-116	BCL2 associated X, apoptosis regulator	Homo sapiens	37-40
18077176-5	2008	Additionally, pro-apoptotic proteins Bax and caspase-3 have been implemented in the oxidative modification of PtdSer resulting in subsequent asymmetric collapse, while anti-apoptotic protein Bcl-2 has been found to prevent this process.	Phosphatidylserines	110-116	caspase 3	Homo sapiens	45-54
18077176-5	2008	Additionally, pro-apoptotic proteins Bax and caspase-3 have been implemented in the oxidative modification of PtdSer resulting in subsequent asymmetric collapse, while anti-apoptotic protein Bcl-2 has been found to prevent this process.	Phosphatidylserines	110-116	BCL2 apoptosis regulator	Homo sapiens	191-196
18045720-2	2008	In this study, the effect of sphingomyelin and phosphatidyl serine on canine parvovirus capsid and on the phospholipase A(2) (PLA(2)) activity of CPV VP1 unique N-terminus was analyzed.	Phosphatidylserines	47-66	VP1	Canine parvovirus	150-153
18220422-10	2008	In addition, PTEN binds synergistically to PI(4,5)P2 and phosphatidylserine, and hence, these anionic lipids do not compete for PTEN binding sites.	Phosphatidylserines	57-75	phosphatase and tensin homolog	Homo sapiens	13-17
20641249-3	2004	On the other hand, PS is also accessible for annexin V binding in necrosis because of disruption of the plasma membrane.	Phosphatidylserines	19-21	annexin A5	Homo sapiens	45-54
20641249-5	2004	Annexin V binds to PS with high affinity (Kd = 7 nM) (3, 7, 8).	Phosphatidylserines	19-21	annexin A5	Homo sapiens	0-9
20641495-3	2004	On the other hand, PS is also accessible for annexin V binding in necrosis because of disruption of the plasma membrane.	Phosphatidylserines	19-21	annexin A5	Homo sapiens	45-54
20641495-5	2004	Annexin V binds to PS with high affinity (Kd = 7 nM) (3, 7, 8).	Phosphatidylserines	19-21	annexin A5	Homo sapiens	0-9
18250442-6	2008	C1q binding and phosphatidylserine (PS) exposure, as measured by annexin V labeling, proceeded concomitantly, and annexin V inhibited C1q binding in a dose-dependent manner.	Phosphatidylserines	36-38	annexin A5	Homo sapiens	65-74
18250442-7	2008	As shown by cosedimentation, surface plasmon resonance, and x-ray crystallographic analyses, C1q recognized PS specifically and avidly (K(D) = 3.7-7 x 10(-8) M), through multiple interactions between its globular domain and the phosphoserine group of PS.	Phosphatidylserines	108-110	complement C1q A chain	Homo sapiens	93-96
18250442-8	2008	Confocal microscopy revealed that the majority of the C1q molecules were distributed in membrane patches where they colocalized with PS.	Phosphatidylserines	133-135	complement C1q A chain	Homo sapiens	54-57
18250442-9	2008	In summary, PS is one of the C1q ligands on apoptotic cells, and C1q-PS interaction takes place at early stages of apoptosis, in newly organized membrane patches.	Phosphatidylserines	12-14	complement C1q A chain	Homo sapiens	29-32
18057187-5	2008	Exogenous TGF-beta1 and a liposome mixture containing PS mimicked sevoflurane-mediated ERK and Akt phosphorylation and HSP70 induction in HK-2 cells.	Phosphatidylserines	54-56	mitogen-activated protein kinase 1	Homo sapiens	87-90
18057187-5	2008	Exogenous TGF-beta1 and a liposome mixture containing PS mimicked sevoflurane-mediated ERK and Akt phosphorylation and HSP70 induction in HK-2 cells.	Phosphatidylserines	54-56	AKT serine/threonine kinase 1	Homo sapiens	95-98
18057187-5	2008	Exogenous TGF-beta1 and a liposome mixture containing PS mimicked sevoflurane-mediated ERK and Akt phosphorylation and HSP70 induction in HK-2 cells.	Phosphatidylserines	54-56	heat shock protein family A (Hsp70) member 4	Homo sapiens	119-124
18057187-7	2008	Furthermore, a neutralizing TGF-beta1 antibody or exogenous annexin V to bind PS prevented sevoflurane-induced ERK and Akt phosphorylation and HSP70 induction in HK-2 cells.	Phosphatidylserines	78-80	transforming growth factor beta 1	Homo sapiens	28-37
18057187-7	2008	Furthermore, a neutralizing TGF-beta1 antibody or exogenous annexin V to bind PS prevented sevoflurane-induced ERK and Akt phosphorylation and HSP70 induction in HK-2 cells.	Phosphatidylserines	78-80	annexin A5	Homo sapiens	60-69
18057187-7	2008	Furthermore, a neutralizing TGF-beta1 antibody or exogenous annexin V to bind PS prevented sevoflurane-induced ERK and Akt phosphorylation and HSP70 induction in HK-2 cells.	Phosphatidylserines	78-80	mitogen-activated protein kinase 1	Homo sapiens	111-114
18057187-7	2008	Furthermore, a neutralizing TGF-beta1 antibody or exogenous annexin V to bind PS prevented sevoflurane-induced ERK and Akt phosphorylation and HSP70 induction in HK-2 cells.	Phosphatidylserines	78-80	AKT serine/threonine kinase 1	Homo sapiens	119-122
18057187-7	2008	Furthermore, a neutralizing TGF-beta1 antibody or exogenous annexin V to bind PS prevented sevoflurane-induced ERK and Akt phosphorylation and HSP70 induction in HK-2 cells.	Phosphatidylserines	78-80	heat shock protein family A (Hsp70) member 4	Homo sapiens	143-148
18246479-4	2008	Apoptosis was simultaneously analyzed by observation of cell morphology as well as flowcytometric determination of Annexin V binding to phosphatidylserine and propidium iodide exclusion.	Phosphatidylserines	136-154	annexin A5	Homo sapiens	115-124
17916326-5	2008	Absorption measurements indicate preferential oxidative interaction of HbE and alpha-globin subunit with unilamellar vesicles containing PE and PS compared to normal HbA.	Phosphatidylserines	144-146	hemoglobin subunit epsilon 1	Homo sapiens	71-74
18061140-6	2008	In addition, a greater amount of L55P TTR bound with high affinity to membranes made from anionic phospholipids, phosphatidylglycerol (PG) and phosphatidylserine (PS), than to membranes made from zwitterionic phospholipid phosphatidylcholine (PC).	Phosphatidylserines	143-161	transthyretin	Homo sapiens	38-41
18061140-6	2008	In addition, a greater amount of L55P TTR bound with high affinity to membranes made from anionic phospholipids, phosphatidylglycerol (PG) and phosphatidylserine (PS), than to membranes made from zwitterionic phospholipid phosphatidylcholine (PC).	Phosphatidylserines	163-165	transthyretin	Homo sapiens	38-41
18488416-3	2008	In addition, this treatment induced the expression of tissue factor (CD142) on HUVECs (54 +/- 20% CD142+ cells vs 4 +/- 2% CD142+ cells in control; p = 0.008) and increased exposure of phosphatidylserine (PS) (29 +/- 2% PS+ cells vs. 12 +/- 5% PS+ cells in control; p &lt; 0.001).	Phosphatidylserines	185-203	coagulation factor III, tissue factor	Homo sapiens	69-74
18488416-3	2008	In addition, this treatment induced the expression of tissue factor (CD142) on HUVECs (54 +/- 20% CD142+ cells vs 4 +/- 2% CD142+ cells in control; p = 0.008) and increased exposure of phosphatidylserine (PS) (29 +/- 2% PS+ cells vs. 12 +/- 5% PS+ cells in control; p &lt; 0.001).	Phosphatidylserines	220-223	coagulation factor III, tissue factor	Homo sapiens	69-74
18488416-3	2008	In addition, this treatment induced the expression of tissue factor (CD142) on HUVECs (54 +/- 20% CD142+ cells vs 4 +/- 2% CD142+ cells in control; p = 0.008) and increased exposure of phosphatidylserine (PS) (29 +/- 2% PS+ cells vs. 12 +/- 5% PS+ cells in control; p &lt; 0.001).	Phosphatidylserines	244-247	coagulation factor III, tissue factor	Homo sapiens	69-74
17889282-2	2008	TF coagulant activity is critically dependent on the presence of aminophospholipids, such as phosphatidylserine (PS) and phosphatidylethanolamine (PE), but it is unknown whether or not TF-exposing EMP are enriched in such aminophospholipids.	Phosphatidylserines	93-111	coagulation factor III, tissue factor	Homo sapiens	0-2
17889282-2	2008	TF coagulant activity is critically dependent on the presence of aminophospholipids, such as phosphatidylserine (PS) and phosphatidylethanolamine (PE), but it is unknown whether or not TF-exposing EMP are enriched in such aminophospholipids.	Phosphatidylserines	113-115	coagulation factor III, tissue factor	Homo sapiens	0-2
18004876-9	2007	Comparison of cyt c-deficient HeLa cells and mouse embryonic cells with those expressing a full complement of cyt c demonstrated the involvement of cyt c peroxidase activity in selective catalysis of peroxidation of CL, PS, and PI, which corresponded to the potency of these lipids in inducing cyt c"s structural destabilization.	Phosphatidylserines	220-222	cytochrome c, somatic	Homo sapiens	110-115
18004876-9	2007	Comparison of cyt c-deficient HeLa cells and mouse embryonic cells with those expressing a full complement of cyt c demonstrated the involvement of cyt c peroxidase activity in selective catalysis of peroxidation of CL, PS, and PI, which corresponded to the potency of these lipids in inducing cyt c"s structural destabilization.	Phosphatidylserines	220-222	cytochrome c, somatic	Homo sapiens	110-115
18004876-9	2007	Comparison of cyt c-deficient HeLa cells and mouse embryonic cells with those expressing a full complement of cyt c demonstrated the involvement of cyt c peroxidase activity in selective catalysis of peroxidation of CL, PS, and PI, which corresponded to the potency of these lipids in inducing cyt c"s structural destabilization.	Phosphatidylserines	220-222	cytochrome c, somatic	Homo sapiens	110-115
27263957-7	2007	There were positive correlations between caspase-3 activation and PS externaization,  Psim depolarization, CD63, and also between PS externaization and CD62P in incubations with A23187 at 5th hours of incubations.	Phosphatidylserines	66-68	caspase 3	Homo sapiens	41-50
18082433-2	2007	Here we showed that TIM-4 is expressed on human and mouse macrophages and dendritic cells, and both TIM-4 and TIM-1 specifically bound phosphatidylserine (PS) on the surface of apoptotic cells but not any other phospholipid tested.	Phosphatidylserines	135-153	T cell immunoglobulin and mucin domain containing 4	Mus musculus	100-105
18082433-2	2007	Here we showed that TIM-4 is expressed on human and mouse macrophages and dendritic cells, and both TIM-4 and TIM-1 specifically bound phosphatidylserine (PS) on the surface of apoptotic cells but not any other phospholipid tested.	Phosphatidylserines	135-153	hepatitis A virus cellular receptor 1	Mus musculus	110-115
18082433-5	2007	TIM-4 mAbs that blocked PS binding and phagocytosis mapped to epitopes in this binding cavity.	Phosphatidylserines	24-26	T cell immunoglobulin and mucin domain containing 4	Homo sapiens	0-5
17878267-9	2007	Our study suggests that DHA-induced activation of PLC/IP3 pathway and activation of PKCgamma/delta, via its action on PS binding site, may be involved in apoptosis in U937 cells.	Phosphatidylserines	118-120	protein kinase C gamma	Homo sapiens	84-98
17981141-6	2007	Intriguingly, phosphatidylethanolamine and phosphatidylserine stimulate GTPase-activating protein (GAP) activity of Rga1p and Rga2p toward Cdc42p, whereas PI(4,5)P(2) inhibits it.	Phosphatidylserines	43-61	GTPase-activating protein RGA1	Saccharomyces cerevisiae S288C	116-121
17981141-6	2007	Intriguingly, phosphatidylethanolamine and phosphatidylserine stimulate GTPase-activating protein (GAP) activity of Rga1p and Rga2p toward Cdc42p, whereas PI(4,5)P(2) inhibits it.	Phosphatidylserines	43-61	GTPase-activating protein RGA2	Saccharomyces cerevisiae S288C	126-131
17981141-6	2007	Intriguingly, phosphatidylethanolamine and phosphatidylserine stimulate GTPase-activating protein (GAP) activity of Rga1p and Rga2p toward Cdc42p, whereas PI(4,5)P(2) inhibits it.	Phosphatidylserines	43-61	Rho family GTPase CDC42	Saccharomyces cerevisiae S288C	139-145
18000611-2	2007	In the present study we have explored the relationship between the PS density of membranes and the rate of thrombin generation in plasma.	Phosphatidylserines	67-69	coagulation factor II, thrombin	Homo sapiens	107-115
18000611-4	2007	The duration of the initiation phase of FXa-driven thrombin generation decreased dramatically with increasing PS density.	Phosphatidylserines	110-112	coagulation factor X	Homo sapiens	40-43
18000611-4	2007	The duration of the initiation phase of FXa-driven thrombin generation decreased dramatically with increasing PS density.	Phosphatidylserines	110-112	coagulation factor II, thrombin	Homo sapiens	51-59
17701359-8	2007	We demonstrated also that myeloperoxidase is eluted together with pure phosphatidylserine liposomes or liposomes composed of phosphatidylserine and phosphatidylcholine in gel filtration, but not with pure phosphatidylcholine liposomes.	Phosphatidylserines	71-89	myeloperoxidase	Homo sapiens	26-41
17826384-4	2007	Annexin V-positive MP levels (expressed as nanomoles per liter of phosphatidylserine equivalent) were higher in patients with AF (median 9.3, interquartile range 6.8 to 17.3 nmol/L) than in control subjects with cardiovascular risk factors (median 4.9, interquartile range 3.7 to 8.4 nmol/L) and control subjects without cardiovascular risk factors (median 3.2, interquantile range 2.3 to 4.6 nmol/L; p&lt;0.001).	Phosphatidylserines	66-84	annexin A5	Homo sapiens	0-9
17613532-2	2007	Anx-A5 significantly activated the induction and propagation of mineral formation when incorporated into synthetic nucleation complexes made of amorphous calcium phosphate (ACP) and Anx-A5 or of phosphatidylserine (PS) plus ACP (PS-CPLX) and Anx-A5.	Phosphatidylserines	215-217	annexin A5	Homo sapiens	0-6
17613532-6	2007	The ability of Anx-A5 to enhance the nucleation and growth of mineral appears to stem from its ability to form two-dimensional crystalline arrays on PS-containing monolayers.	Phosphatidylserines	149-151	annexin A5	Homo sapiens	15-21
17613532-8	2007	Comparing the various annexins for their ability to activate PS-CPLX nucleation yields the following: avian cartilage Anx-A5 &gt; human placental Anx-A5 &gt; avian liver Anx-A5 &gt; or = avian cartilage Anx-A6 &gt;&gt; cartilage Anx-A2.	Phosphatidylserines	61-63	annexin A5	Homo sapiens	118-124
17613532-8	2007	Comparing the various annexins for their ability to activate PS-CPLX nucleation yields the following: avian cartilage Anx-A5 &gt; human placental Anx-A5 &gt; avian liver Anx-A5 &gt; or = avian cartilage Anx-A6 &gt;&gt; cartilage Anx-A2.	Phosphatidylserines	61-63	annexin A5	Homo sapiens	146-152
17613532-8	2007	Comparing the various annexins for their ability to activate PS-CPLX nucleation yields the following: avian cartilage Anx-A5 &gt; human placental Anx-A5 &gt; avian liver Anx-A5 &gt; or = avian cartilage Anx-A6 &gt;&gt; cartilage Anx-A2.	Phosphatidylserines	61-63	annexin A5	Homo sapiens	146-152
17613532-9	2007	The stimulatory effect of human placental Anx-A5 and avian cartilage Anx-A6 depended on the presence of PS, since in its absence they either had no effect or actually inhibited the nucleation activity of ACP.	Phosphatidylserines	104-106	annexin A5	Homo sapiens	42-48
17643252-3	2007	We demonstrate that after treatment with PS, murine DCs display reduced expression of MHC II, CD80, CD86 and CD40, but increased programmed death ligand-1 (PD-L1 and PD-L2); and increased IL-10 and inhibited IL-12 cytokine production.	Phosphatidylserines	41-43	histocompatibility-2, MHC	Mus musculus	86-92
17643252-3	2007	We demonstrate that after treatment with PS, murine DCs display reduced expression of MHC II, CD80, CD86 and CD40, but increased programmed death ligand-1 (PD-L1 and PD-L2); and increased IL-10 and inhibited IL-12 cytokine production.	Phosphatidylserines	41-43	CD80 antigen	Mus musculus	94-98
17643252-3	2007	We demonstrate that after treatment with PS, murine DCs display reduced expression of MHC II, CD80, CD86 and CD40, but increased programmed death ligand-1 (PD-L1 and PD-L2); and increased IL-10 and inhibited IL-12 cytokine production.	Phosphatidylserines	41-43	CD86 antigen	Mus musculus	100-104
17643252-3	2007	We demonstrate that after treatment with PS, murine DCs display reduced expression of MHC II, CD80, CD86 and CD40, but increased programmed death ligand-1 (PD-L1 and PD-L2); and increased IL-10 and inhibited IL-12 cytokine production.	Phosphatidylserines	41-43	CD40 antigen	Mus musculus	109-113
17643252-3	2007	We demonstrate that after treatment with PS, murine DCs display reduced expression of MHC II, CD80, CD86 and CD40, but increased programmed death ligand-1 (PD-L1 and PD-L2); and increased IL-10 and inhibited IL-12 cytokine production.	Phosphatidylserines	41-43	CD274 antigen	Mus musculus	156-161
17643252-3	2007	We demonstrate that after treatment with PS, murine DCs display reduced expression of MHC II, CD80, CD86 and CD40, but increased programmed death ligand-1 (PD-L1 and PD-L2); and increased IL-10 and inhibited IL-12 cytokine production.	Phosphatidylserines	41-43	programmed cell death 1 ligand 2	Mus musculus	166-171
17643252-3	2007	We demonstrate that after treatment with PS, murine DCs display reduced expression of MHC II, CD80, CD86 and CD40, but increased programmed death ligand-1 (PD-L1 and PD-L2); and increased IL-10 and inhibited IL-12 cytokine production.	Phosphatidylserines	41-43	interleukin 10	Mus musculus	188-193
17643252-7	2007	Furthermore, PS-treated DCs enhance the ratio of CD4(+) CD25(high)Foxp3(+) T cells to CD4(+) T cells and PD-1 expression on CD4(+) T cells.	Phosphatidylserines	13-15	CD4 molecule	Sus scrofa	49-52
17643252-7	2007	Furthermore, PS-treated DCs enhance the ratio of CD4(+) CD25(high)Foxp3(+) T cells to CD4(+) T cells and PD-1 expression on CD4(+) T cells.	Phosphatidylserines	13-15	interleukin 2 receptor subunit alpha	Sus scrofa	56-60
17643252-7	2007	Furthermore, PS-treated DCs enhance the ratio of CD4(+) CD25(high)Foxp3(+) T cells to CD4(+) T cells and PD-1 expression on CD4(+) T cells.	Phosphatidylserines	13-15	CD4 antigen	Mus musculus	86-89
17643252-7	2007	Furthermore, PS-treated DCs enhance the ratio of CD4(+) CD25(high)Foxp3(+) T cells to CD4(+) T cells and PD-1 expression on CD4(+) T cells.	Phosphatidylserines	13-15	CD4 antigen	Mus musculus	86-89
17478491-1	2007	BACKGROUND: Activated uraemic platelets expose the aminophospholipid phosphatidylserine (PS) at their outer surface, which generates a cell procoagulant phenotype and seems at least partly due to an increase in cell caspase-3 activity.	Phosphatidylserines	89-91	caspase 3	Homo sapiens	216-225
17478491-4	2007	METHODS: Platelet PS-exposure was assayed by flow cytometry using annexin V.	Phosphatidylserines	18-20	annexin A5	Homo sapiens	66-75
17710129-4	2007	Expression of phosphatidylserine (PS) on the surface of both macrophages and their apoptotic targets is required for efficient engulfment of the apoptotic cells, and it has been proposed that ABCA1 is required for transbilayer externalization of PS to the surface of both cell types.	Phosphatidylserines	14-32	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	192-197
17710129-4	2007	Expression of phosphatidylserine (PS) on the surface of both macrophages and their apoptotic targets is required for efficient engulfment of the apoptotic cells, and it has been proposed that ABCA1 is required for transbilayer externalization of PS to the surface of both cell types.	Phosphatidylserines	34-36	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	192-197
17478478-2	2007	PISD converts phosphatidylserine to phosphatidylethanolamine during lipid synthesis.	Phosphatidylserines	14-32	phosphatidylserine decarboxylase	Homo sapiens	0-4
17583394-2	2007	OVA (ovalbumin)-specific Th1 clone 42-6A cells cocultured with antigen presenting cells (APCs) from spleen resulted in high levels of OVA-specific IFN-gamma production by the treatment of phosphatidylserine (PS), but not phosphatidic acid (PA), liposomes-encapsulated OVA (OVA-liposomes).	Phosphatidylserines	188-206	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	5-14
17583394-2	2007	OVA (ovalbumin)-specific Th1 clone 42-6A cells cocultured with antigen presenting cells (APCs) from spleen resulted in high levels of OVA-specific IFN-gamma production by the treatment of phosphatidylserine (PS), but not phosphatidic acid (PA), liposomes-encapsulated OVA (OVA-liposomes).	Phosphatidylserines	188-206	negative elongation factor complex member C/D, Th1l	Mus musculus	25-28
17583394-2	2007	OVA (ovalbumin)-specific Th1 clone 42-6A cells cocultured with antigen presenting cells (APCs) from spleen resulted in high levels of OVA-specific IFN-gamma production by the treatment of phosphatidylserine (PS), but not phosphatidic acid (PA), liposomes-encapsulated OVA (OVA-liposomes).	Phosphatidylserines	188-206	interferon gamma	Mus musculus	147-156
17583394-2	2007	OVA (ovalbumin)-specific Th1 clone 42-6A cells cocultured with antigen presenting cells (APCs) from spleen resulted in high levels of OVA-specific IFN-gamma production by the treatment of phosphatidylserine (PS), but not phosphatidic acid (PA), liposomes-encapsulated OVA (OVA-liposomes).	Phosphatidylserines	208-210	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	5-14
17583394-2	2007	OVA (ovalbumin)-specific Th1 clone 42-6A cells cocultured with antigen presenting cells (APCs) from spleen resulted in high levels of OVA-specific IFN-gamma production by the treatment of phosphatidylserine (PS), but not phosphatidic acid (PA), liposomes-encapsulated OVA (OVA-liposomes).	Phosphatidylserines	208-210	negative elongation factor complex member C/D, Th1l	Mus musculus	25-28
17583394-2	2007	OVA (ovalbumin)-specific Th1 clone 42-6A cells cocultured with antigen presenting cells (APCs) from spleen resulted in high levels of OVA-specific IFN-gamma production by the treatment of phosphatidylserine (PS), but not phosphatidic acid (PA), liposomes-encapsulated OVA (OVA-liposomes).	Phosphatidylserines	208-210	interferon gamma	Mus musculus	147-156
17583394-3	2007	The IFN-gamma production was increased in a manner dependent on the PS content of the liposomes and inhibited by the addition of annexin V, a PS binding protein.	Phosphatidylserines	68-70	interferon gamma	Mus musculus	4-13
17583394-3	2007	The IFN-gamma production was increased in a manner dependent on the PS content of the liposomes and inhibited by the addition of annexin V, a PS binding protein.	Phosphatidylserines	142-144	interferon gamma	Mus musculus	4-13
17583394-3	2007	The IFN-gamma production was increased in a manner dependent on the PS content of the liposomes and inhibited by the addition of annexin V, a PS binding protein.	Phosphatidylserines	142-144	annexin A5	Mus musculus	129-138
17583394-6	2007	These results first suggest that antigen delivery using negatively charged liposomes containing PS is very useful for the enhancement of IFN-gamma production in Th1-cell therapy.	Phosphatidylserines	96-98	interferon gamma	Mus musculus	137-146
17583394-6	2007	These results first suggest that antigen delivery using negatively charged liposomes containing PS is very useful for the enhancement of IFN-gamma production in Th1-cell therapy.	Phosphatidylserines	96-98	negative elongation factor complex member C/D, Th1l	Mus musculus	161-164
17533418-12	2007	The PPAR antagonists (BADGE and GW9662) partially prevented the anti-inflammatory effects of PS administration.	Phosphatidylserines	93-95	peroxisome proliferator activated receptor alpha	Mus musculus	4-8
19003007-3	2007	Here we report an improved procedure to detect neutrophil apoptosis by simultaneous staining for exposed PS with Cy3-labeled annexin V (Cy3) and for membrane integrity with the vital dye 6-carboxyfluorescein diacetate (6-CFDA) based on the APOAC apoptosis detection kit (Sigma).	Phosphatidylserines	105-107	annexin A5	Homo sapiens	125-134
17332248-9	2007	PCI and annexin V were found to be endogenously colocalized in atherosclerotic plaques, supporting the hypothesis that exposure of oxidized PE and/or PS may be important for the local regulation of PCI activity in vivo.	Phosphatidylserines	150-152	annexin A5	Homo sapiens	8-17
17289346-3	2007	Here we show that Wnt1 is critical for protection in the SH-SY5Y neuronal cell line against genomic DNA degradation, membrane phosphatidylserine (PS) exposure, and microglial activation, since these neuroprotective attributes of Wnt1 are lost during gene silencing of Wnt1 protein expression.	Phosphatidylserines	126-144	Wnt family member 1	Homo sapiens	18-22
17289346-3	2007	Here we show that Wnt1 is critical for protection in the SH-SY5Y neuronal cell line against genomic DNA degradation, membrane phosphatidylserine (PS) exposure, and microglial activation, since these neuroprotective attributes of Wnt1 are lost during gene silencing of Wnt1 protein expression.	Phosphatidylserines	146-148	Wnt family member 1	Homo sapiens	18-22
17878960-3	2007	The antithrombotic effect exerted by ANXA5 is thought to be mediated mainly by mechanical shielding of phospholipids, phosphatidylserine in particular, thereby reducing their availability for coagulation reactions.	Phosphatidylserines	118-136	annexin A5	Homo sapiens	37-42
17617677-0	2007	Mercury induces the externalization of phosphatidyl-serine in human renal proximal tubule (HK-2) cells.	Phosphatidylserines	39-58	hexokinase 2	Homo sapiens	91-95
17430887-6	2007	We measured the binding of catalytically competent mouse PLC-zeta to phospholipid vesicles: for 2:1 phosphatidylcholine/phosphatidylserine (PC/PS) vesicles, the molar partition coefficient, K, is too weak to be of physiological significance.	Phosphatidylserines	120-138	phospholipase C, zeta 1	Mus musculus	57-65
17337472-1	2007	BACKGROUND: Magnetic-activated cell sorting (MACS) using annexin V-conjugated microbeads in a liquid phase eliminates apoptotic spermatozoa based on the externalization of phosphatidylserine (EPS) residues.	Phosphatidylserines	172-190	annexin A5	Homo sapiens	57-66
17367165-6	2007	For the isolated PKCalpha C2 domain in the presence of physiological Ca2+ levels, the target lipids phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) are together sufficient to recruit the PKCalpha C2 domain to a lipid mixture mimicking the plasma membrane inner leaflet.	Phosphatidylserines	100-118	protein kinase C alpha	Homo sapiens	17-25
17367165-6	2007	For the isolated PKCalpha C2 domain in the presence of physiological Ca2+ levels, the target lipids phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) are together sufficient to recruit the PKCalpha C2 domain to a lipid mixture mimicking the plasma membrane inner leaflet.	Phosphatidylserines	100-118	protein kinase C alpha	Homo sapiens	212-220
17367165-6	2007	For the isolated PKCalpha C2 domain in the presence of physiological Ca2+ levels, the target lipids phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) are together sufficient to recruit the PKCalpha C2 domain to a lipid mixture mimicking the plasma membrane inner leaflet.	Phosphatidylserines	120-122	protein kinase C alpha	Homo sapiens	17-25
17175137-4	2007	Consistent with the hypothesis that exposed PS enhances prothrombinase activity; pre-incubation with annexin V blocks the increase in thrombin formation.	Phosphatidylserines	44-46	coagulation factor II	Mus musculus	59-67
17372676-1	2007	The present study investigated the mechanisms underlying the inhibition of platelet phosphatidylserine (PS) exposure by GPIIb/IIIa blockade.	Phosphatidylserines	84-102	integrin subunit alpha 2b	Homo sapiens	120-125
17372676-7	2007	The reduction of non-PS-exposing platelets was attenuated by GPIIb/IIIa blockade, while little translocase activity was seen in PS-exposing platelets.	Phosphatidylserines	21-23	integrin subunit alpha 2b	Homo sapiens	61-66
17440717-3	2007	In this study the interaction of annexin A4 with large unilamellar vesicles (LUV) prepared from phosphatidylserine (PS) or from phosphatidic acid (PA) is investigated at neutral and acidic pH.	Phosphatidylserines	96-114	annexin A4	Homo sapiens	33-43
17440717-3	2007	In this study the interaction of annexin A4 with large unilamellar vesicles (LUV) prepared from phosphatidylserine (PS) or from phosphatidic acid (PA) is investigated at neutral and acidic pH.	Phosphatidylserines	116-118	annexin A4	Homo sapiens	33-43
17349923-0	2007	Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid beta and interferon-gamma-induced microglial activation.	Phosphatidylserines	0-18	interferon gamma	Homo sapiens	89-105
17349923-2	2007	Phospholipids such as phosphatidylserine (PS) and phosphatidylcholine (PC) have been reported to modulate the immune function of phagocytes.	Phosphatidylserines	22-40	surfactant protein C	Homo sapiens	42-44
17202128-4	2007	Compared with the COX-2(+/+) mouse brain, the brain of the COX-2(-/-) mouse had a statistically significant 15% increase in phosphatidylserine (PtdSer) and significant 37, 27, and 32% reductions in triacylglycerol and cholesterol concentrations and in the cholesterol-to-phospholipid ratio, respectively.	Phosphatidylserines	124-142	cytochrome c oxidase II, mitochondrial	Mus musculus	59-64
17286963-6	2007	BzATP- and ATP-induced erythrocyte PS exposure was impaired by oxidised ATP, as well as in erythrocytes from subjects who had inherited loss-of-function polymorphisms in the P2X(7) receptor.	Phosphatidylserines	35-37	purinergic receptor P2X 7	Homo sapiens	174-189
17295517-4	2007	Flow cytometric analysis of the externalization of phosphatidylserine (PS) using the annexin V/PI method on EEL-treated HL-60 cells showed a concentration-dependent increase of apoptosis.	Phosphatidylserines	51-69	annexin A5	Homo sapiens	85-94
17035298-4	2007	Incubation of INS 832/13 cell lysates with polyphosphoinositides (e.g., PIP(2)), phosphatidic acid, phosphatidylcholine, and phosphatidylserine significantly promoted trafficking of cytosolic Rac1 to the membrane fraction.	Phosphatidylserines	125-143	Rac family small GTPase 1	Rattus norvegicus	192-196
17155950-2	2007	PS expression, associated with apoptosis in nucleated cells, would be expected to be reversed by aminophospholipid translocase (APLT) activity.	Phosphatidylserines	0-2	ATPase phospholipid transporting 8A1	Homo sapiens	97-126
17155950-2	2007	PS expression, associated with apoptosis in nucleated cells, would be expected to be reversed by aminophospholipid translocase (APLT) activity.	Phosphatidylserines	0-2	ATPase phospholipid transporting 8A1	Homo sapiens	128-132
17021816-2	2007	Radiolabeled annexin-V (anxV) is an ideal probe for in vivo apoptosis detection owing to its strong affinity for phosphatidylserine (PS), the molecular flag on the surface of apoptotic cells.	Phosphatidylserines	113-131	annexin A5	Mus musculus	13-22
17021816-2	2007	Radiolabeled annexin-V (anxV) is an ideal probe for in vivo apoptosis detection owing to its strong affinity for phosphatidylserine (PS), the molecular flag on the surface of apoptotic cells.	Phosphatidylserines	133-135	annexin A5	Mus musculus	13-22
17182843-5	2007	Although the interaction of granuphilin with syntaxin-1a is critical for the targeting activity, exophilin4 does this primarily through the affinity of its C2A domain toward the plasma membrane phospholipids phosphatidylserine and phosphatidylinositol-4,5-bisphosphate.	Phosphatidylserines	208-226	synaptotagmin like 2	Homo sapiens	97-107
17182843-6	2007	Notably, the binding activity to phosphatidylserine is inhibited by a physiological range of the Ca(2+) concentration attained after secretagogue stimulation, which presents a striking contrast to the Ca(2+)-stimulatory activity of the C2A domain of synaptotagmin I.	Phosphatidylserines	33-51	synaptotagmin 1	Homo sapiens	250-265
17126953-3	2007	On the other hand, phospholipids such as phosphatidylserine (PS) and phosphatidylcholine (PC) have been reported to modulate the immune function of phagocytes.	Phosphatidylserines	41-59	surfactant protein C	Homo sapiens	61-63
17020537-9	2007	Hsp22 binds more strongly to vesicles made of lipids containing a phosphatidic acid, phosphatidylinositol or phosphatidylserine headgroup (known to be present in the inner leaflet of plasma membrane) compared with lipid vesicles made of a phosphatidylcholine head-group alone.	Phosphatidylserines	109-127	heat shock protein family B (small) member 8	Homo sapiens	0-5
17209622-2	2007	With phosphatidylserine (PS)-containing stearoyl and varying acyls in the sn-1 and -2 positions, respectively, TFP increased the mma in a manner that depended on the number of double bonds and chain length.	Phosphatidylserines	5-23	solute carrier family 38 member 3	Homo sapiens	74-85
17622749-3	2007	We hypothesized that volatile anesthetics perturb the structure of the plasma membrane lipid bilayer, causing externalization of phosphatidylserine (PS) to the outer surface on renal tubule cells leading to the increased generation of transforming growth factor-beta1 (TGF-beta1), a cytokine with antinecrotic properties.	Phosphatidylserines	129-147	transforming growth factor beta 1	Homo sapiens	235-267
17622749-3	2007	We hypothesized that volatile anesthetics perturb the structure of the plasma membrane lipid bilayer, causing externalization of phosphatidylserine (PS) to the outer surface on renal tubule cells leading to the increased generation of transforming growth factor-beta1 (TGF-beta1), a cytokine with antinecrotic properties.	Phosphatidylserines	129-147	transforming growth factor beta 1	Homo sapiens	269-278
16940423-0	2007	Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells.	Phosphatidylserines	56-74	galectin 1	Homo sapiens	6-28
16940423-3	2007	Here we show that several members of the human galectin family of glycan binding proteins (galectins-1, -2, and -4) induce PS exposure in a carbohydrate-dependent fashion in activated, but not resting, human neutrophils and in several leukocyte cell lines.	Phosphatidylserines	123-125	galectin 1	Homo sapiens	91-114
17436686-3	2007	LPS-induced expression of E-selectin on human endothelial cells was inhibited by oxidized phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, and phosphatidic acids.	Phosphatidylserines	111-129	selectin E	Homo sapiens	26-36
17305532-2	2007	Annexin A5 represents a typical member of this protein family and is a natural occurring highly specific ligand for phosphatidylserine (PS).	Phosphatidylserines	116-134	annexin A5	Homo sapiens	0-10
17305532-2	2007	Annexin A5 represents a typical member of this protein family and is a natural occurring highly specific ligand for phosphatidylserine (PS).	Phosphatidylserines	136-138	annexin A5	Homo sapiens	0-10
17305532-7	2007	Annexin A5 may interfere in vivo with the immunosuppressive effects of apoptotic cells since it preferentially binds PS with high affinity and inhibits apoptotic cell uptake by macrophages.	Phosphatidylserines	117-119	annexin A5	Homo sapiens	0-10
17222180-0	2007	Phosphatidylserine induces functional and structural alterations of the membrane-associated pleckstrin homology domain of phospholipase C-delta1.	Phosphatidylserines	0-18	phospholipase C delta 1	Homo sapiens	122-144
17311586-1	2007	Yeast mcd4-174 mutants are blocked in glycosylphosphatidylinositol (GPI) anchoring of protein, but the stage at which GPI biosynthesis is interrupted in vivo has not been identified, and Mcd4p has also been implicated in phosphatidylserine and ATP transport.	Phosphatidylserines	221-239	mannose-ethanolamine phosphotransferase MCD4	Saccharomyces cerevisiae S288C	6-10
18176897-2	2007	Our data indicated that ASN (10 microM) inhibited [3H]AA incorporation into phosphatidylethanolamine (PE), phosphatidylcholine (PC) and phosphatidylserine (PS) together with phosphatidic acid (PA) by 13%, 27% and 38%, respectively.	Phosphatidylserines	136-154	synuclein alpha	Rattus norvegicus	24-27
18176897-2	2007	Our data indicated that ASN (10 microM) inhibited [3H]AA incorporation into phosphatidylethanolamine (PE), phosphatidylcholine (PC) and phosphatidylserine (PS) together with phosphatidic acid (PA) by 13%, 27% and 38%, respectively.	Phosphatidylserines	156-158	synuclein alpha	Rattus norvegicus	24-27
17294366-1	2007	Expression of phosphotidylserine by fetal oocytes in culture renders significant numbers of such cells able to bind AnnexinV-coated microbeads and allows their separation from Annexin V-negative oocytes on a Magnetic Cell Separation (MACS) column in a magnetic field.	Phosphatidylserines	14-32	annexin A5	Mus musculus	176-185
17169974-5	2007	NEX-1, -2, and -3 showed the binding activities to phosphatidylserine, phosphatidylinositol and phosphatidylethanolamine, but not to phosphatidylcholine.	Phosphatidylserines	51-69	Annexin	Caenorhabditis elegans	0-17
17453410-1	2007	In hair cells of the inner ear, phosphatidylserine (PS), detected with fluorescent annexin V labeling, was rapidly exposed on the external leaflet of apical plasma membranes upon dissection of the organ of Corti.	Phosphatidylserines	32-50	annexin A5	Homo sapiens	83-92
17453410-1	2007	In hair cells of the inner ear, phosphatidylserine (PS), detected with fluorescent annexin V labeling, was rapidly exposed on the external leaflet of apical plasma membranes upon dissection of the organ of Corti.	Phosphatidylserines	52-54	annexin A5	Homo sapiens	83-92
17453412-3	2007	We tested this idea by reconstituting recombinant CLIC4 in planar bilayers containing phosphatidyethanolamine, phosphatidylserine and cholesterol, recording ion channels with a maximum conductance of approximately 15 pS in KCl under both oxidizing and reducing conditions.	Phosphatidylserines	111-129	chloride intracellular channel 4	Homo sapiens	50-55
18605231-6	2007	Annexin-5 binding studies indicated an elevation in exposure of PS on the surface of the plasma membrane in DPPE-treated cells.	Phosphatidylserines	64-66	annexin A5	Homo sapiens	0-9
16844202-2	2007	Exposure of TF bearing cells to calcium ionophore has been reported to increase TF activity, de-encrypt TF, by phosphatidylserine (PS)-dependent and -independent mechanisms.	Phosphatidylserines	111-129	coagulation factor III, tissue factor	Homo sapiens	12-14
16844202-2	2007	Exposure of TF bearing cells to calcium ionophore has been reported to increase TF activity, de-encrypt TF, by phosphatidylserine (PS)-dependent and -independent mechanisms.	Phosphatidylserines	111-129	coagulation factor III, tissue factor	Homo sapiens	80-82
16844202-2	2007	Exposure of TF bearing cells to calcium ionophore has been reported to increase TF activity, de-encrypt TF, by phosphatidylserine (PS)-dependent and -independent mechanisms.	Phosphatidylserines	111-129	coagulation factor III, tissue factor	Homo sapiens	80-82
16844202-2	2007	Exposure of TF bearing cells to calcium ionophore has been reported to increase TF activity, de-encrypt TF, by phosphatidylserine (PS)-dependent and -independent mechanisms.	Phosphatidylserines	131-133	coagulation factor III, tissue factor	Homo sapiens	12-14
16844202-2	2007	Exposure of TF bearing cells to calcium ionophore has been reported to increase TF activity, de-encrypt TF, by phosphatidylserine (PS)-dependent and -independent mechanisms.	Phosphatidylserines	131-133	coagulation factor III, tissue factor	Homo sapiens	80-82
16844202-2	2007	Exposure of TF bearing cells to calcium ionophore has been reported to increase TF activity, de-encrypt TF, by phosphatidylserine (PS)-dependent and -independent mechanisms.	Phosphatidylserines	131-133	coagulation factor III, tissue factor	Homo sapiens	80-82
17176081-0	2006	Human opioid peptide Met-enkephalin binds to anionic phosphatidylserine in high preference to zwitterionic phosphatidylcholine: natural-abundance 13C NMR study on the binding state in large unilamellar vesicles.	Phosphatidylserines	53-71	proopiomelanocortin	Homo sapiens	21-35
17176081-1	2006	A human opioid neuropeptide, Met-enkephalin (M-Enk: Tyr1-Gly2-Gly3-Phe4-Met5), having no net charge binds to anionic phosphatidylserine (PS) in high preference to zwitterionic phosphatidylcholine (PC).	Phosphatidylserines	117-135	proopiomelanocortin	Homo sapiens	29-43
17176081-1	2006	A human opioid neuropeptide, Met-enkephalin (M-Enk: Tyr1-Gly2-Gly3-Phe4-Met5), having no net charge binds to anionic phosphatidylserine (PS) in high preference to zwitterionic phosphatidylcholine (PC).	Phosphatidylserines	137-139	proopiomelanocortin	Homo sapiens	29-43
17384256-2	2006	Annexin-V-MACS is able to separate apoptotic from nonapoptotic sperm on the basis of their externalization of phosphatidylserine (EPS).	Phosphatidylserines	110-128	annexin A5	Homo sapiens	0-9
17384256-2	2006	Annexin-V-MACS is able to separate apoptotic from nonapoptotic sperm on the basis of their externalization of phosphatidylserine (EPS).	Phosphatidylserines	110-128	myristoylated alanine rich protein kinase C substrate	Homo sapiens	10-14
17123296-8	2006	Calibration studies suggested a PS content less, less than or approximately equal to 2.5%-8% for the membrane domains that stained with lactadherin but not annexin V.	Phosphatidylserines	32-34	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	136-147
17123296-9	2006	CONCLUSIONS: Macrophages may utilize lactadherin to detect PS exposure prior to exposure of sufficient PS to bind annexin V.	Phosphatidylserines	59-61	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	37-48
17390998-2	2006	MATERIALS AND METHODS: Apoptosis of HL60 cells was induced by heat-treatment (430C during 1 h) or by gamma-radiation (8 Gy) and followed at increasing time periods after treatment with Annexin V binding to phosphatidylserine (PS).	Phosphatidylserines	206-224	annexin A5	Homo sapiens	185-194
16961585-6	2006	RESULTS: We found that human alpha-thrombin induced four key manifestations of apoptosis in human platelets: (i) mitochondrial inner transmembrane potential (DeltaPsi m) depolarization; (ii) strong expression of pro-apoptotic Bax and Bak proteins but only weak expression of anti-apoptotic Bcl-2 protein; (iii) caspase-3 activation; and (iv) phosphatidylserine (PS) exposure.	Phosphatidylserines	342-360	coagulation factor II, thrombin	Homo sapiens	35-43
17093075-7	2006	Moreover, in cultures, the PN donor 3-morpholinosydnonimine (SIN-1) blocked staurosporine-induced caspase-3 activation and its downstream effects including PARP-1 [poly-(ADP-ribose) polymerase-1] cleavage and phosphotidylserine inversion, suggesting that peroxynitrite can inhibit caspase-3-mediated apoptosis.	Phosphatidylserines	209-227	MAPK associated protein 1	Homo sapiens	61-66
17042754-5	2006	Phosphatidylserine content was increased in the erg6 mutant only.	Phosphatidylserines	0-18	sterol 24-C-methyltransferase	Saccharomyces cerevisiae S288C	48-52
16905533-4	2006	gammaPKC directly associated with DGKgamma through its accessory domain (AD), depending on Ca2+ as well as phosphatidylserine/diolein in vitro.	Phosphatidylserines	107-125	diacylglycerol kinase gamma	Homo sapiens	34-42
16905548-7	2006	We demonstrate that antibody binding to PS is dependent on plasma protein beta-2-glycoprotein 1 (beta2GP1).	Phosphatidylserines	40-42	apolipoprotein H	Homo sapiens	74-95
16905548-7	2006	We demonstrate that antibody binding to PS is dependent on plasma protein beta-2-glycoprotein 1 (beta2GP1).	Phosphatidylserines	40-42	apolipoprotein H	Homo sapiens	97-105
16714363-7	2006	The 5-lipoxygenase inhibitor zileuton attenuated AN-mediated increases in PS-exposed SRBCs and decreased SRBC retention/adherence in the lung on histological sections.	Phosphatidylserines	74-76	arachidonate 5-lipoxygenase	Rattus norvegicus	4-18
16714363-10	2006	Zileuton attenuation of AN-mediated SRBC PS externalization suggests that a 5-lipoxygenase product(s), secreted by the AN, plays a vital role in altering the adhesive properties of PS-exposed SRBCs to vascular endothelium.	Phosphatidylserines	41-43	arachidonate 5-lipoxygenase	Rattus norvegicus	76-90
16861229-4	2006	Here, we show that the Rho GTPase Rac1 preferentially interacts with phosphatidylserine (PS)-containing bilayers through its polybasic motif (PBM).	Phosphatidylserines	69-87	Rac family small GTPase 1	Homo sapiens	34-38
16861229-4	2006	Here, we show that the Rho GTPase Rac1 preferentially interacts with phosphatidylserine (PS)-containing bilayers through its polybasic motif (PBM).	Phosphatidylserines	89-91	Rac family small GTPase 1	Homo sapiens	34-38
16861229-8	2006	Cell stimulation with PS induces translocation of Rac1 toward the plasma membrane and stimulates GTP loading, membrane ruffling, and filopodia formation.	Phosphatidylserines	22-24	Rac family small GTPase 1	Homo sapiens	50-54
16820967-4	2006	PTPIP51 transfection resulted in the externalization of phosphatidylserine (PS), activation of caspase-3, cleavage of PARP, and condensation of nuclear DNA.	Phosphatidylserines	56-74	regulator of microtubule dynamics 3	Homo sapiens	0-7
16820967-4	2006	PTPIP51 transfection resulted in the externalization of phosphatidylserine (PS), activation of caspase-3, cleavage of PARP, and condensation of nuclear DNA.	Phosphatidylserines	76-78	regulator of microtubule dynamics 3	Homo sapiens	0-7
16940084-8	2006	Additionally, we found that LL37 hemolytic activity was much higher when RBCs were induced to expose phosphatidylserine to the external leaflet of their plasma membranes.	Phosphatidylserines	101-119	cathelicidin antimicrobial peptide	Homo sapiens	28-32
16825594-4	2006	In agreement with in vitro studies, vitamin E-enriched erythrocytes from PLTP-/- mice displayed fewer externalized PS molecules than wild-type controls (-64%, P&lt;0.05).	Phosphatidylserines	115-117	phospholipid transfer protein	Mus musculus	73-77
16684961-7	2006	We show that calcium-stimulated PS exposure in B cells is strain variable, ABCA1 independent, and both preceded by and dependent on a decrease in lipid packing.	Phosphatidylserines	32-34	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	75-80
16860793-3	2006	The C-terminus of Synphilin-1 was found to selectively bind to acidic phospholipids, including phosphatidic acid, phosphatidylserine, and phosphatidylglycerol, but not to naturally charged phospholipids.	Phosphatidylserines	114-132	synuclein alpha interacting protein	Homo sapiens	18-29
16831444-4	2006	The interaction of the hSH3 domains of adhesion and degranulation promoting adapter protein (ADAP) and PRAM-1 (Promyelocytic-Retinoic acid receptor alpha target gene encoding an Adaptor Molecule-1), with phosphatidylcholine-containing liposomes is observed upon incorporation of phosphatidylserine (PS) or phosphoinositides (PIs) into the membrane bilayer.	Phosphatidylserines	279-297	FYN binding protein 1	Homo sapiens	93-97
16831444-4	2006	The interaction of the hSH3 domains of adhesion and degranulation promoting adapter protein (ADAP) and PRAM-1 (Promyelocytic-Retinoic acid receptor alpha target gene encoding an Adaptor Molecule-1), with phosphatidylcholine-containing liposomes is observed upon incorporation of phosphatidylserine (PS) or phosphoinositides (PIs) into the membrane bilayer.	Phosphatidylserines	279-297	PML-RARA regulated adaptor molecule 1	Homo sapiens	103-109
16831444-4	2006	The interaction of the hSH3 domains of adhesion and degranulation promoting adapter protein (ADAP) and PRAM-1 (Promyelocytic-Retinoic acid receptor alpha target gene encoding an Adaptor Molecule-1), with phosphatidylcholine-containing liposomes is observed upon incorporation of phosphatidylserine (PS) or phosphoinositides (PIs) into the membrane bilayer.	Phosphatidylserines	299-301	FYN binding protein 1	Homo sapiens	93-97
16831444-4	2006	The interaction of the hSH3 domains of adhesion and degranulation promoting adapter protein (ADAP) and PRAM-1 (Promyelocytic-Retinoic acid receptor alpha target gene encoding an Adaptor Molecule-1), with phosphatidylcholine-containing liposomes is observed upon incorporation of phosphatidylserine (PS) or phosphoinositides (PIs) into the membrane bilayer.	Phosphatidylserines	299-301	PML-RARA regulated adaptor molecule 1	Homo sapiens	103-109
16646085-2	2006	Our results showed that fibroblasts treated with dRib and H(2)O(2) are induced to undergo apoptosis as demonstrated by reduction in total cell number, chromatin condensation, phosphatidylserine (PS) exposure, activation of caspase-3 and 7, changes in mitochondrial membrane potential and increase in the number of terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL)-positive nuclei.	Phosphatidylserines	175-193	ribbon	Drosophila melanogaster	49-53
16646085-2	2006	Our results showed that fibroblasts treated with dRib and H(2)O(2) are induced to undergo apoptosis as demonstrated by reduction in total cell number, chromatin condensation, phosphatidylserine (PS) exposure, activation of caspase-3 and 7, changes in mitochondrial membrane potential and increase in the number of terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL)-positive nuclei.	Phosphatidylserines	195-197	ribbon	Drosophila melanogaster	49-53
16934082-4	2006	RESULTS: In combination with conventional binding analysis it was found that binding to phorbol 12-myristate 13-acetate-matured THP-1 cells is primarily regulated by PLT P-selectin expression and phagocytosis by combined phosphatidylserine (PS) exposure and glycoprotein (GP) Ibalpha clustering.	Phosphatidylserines	221-239	selectin P	Homo sapiens	170-180
16995311-7	2006	The binding activity of mutant human annexin V from culture supernatant was determined with phosphatidylserine exposed erythrocytes and fluorescein isothiocyanate-annexin V.	Phosphatidylserines	92-110	annexin A5	Homo sapiens	37-46
16800690-3	2006	In this report, we were able to directly monitor single BODIPY 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine (DHPE) and ryanodine receptor type 2 (RyR2) labeled with Cy5 molecules in lipid bilayers containing phosphatidylserine (PS) by using fluorescence microscopy.	Phosphatidylserines	215-233	ryanodine receptor 2	Homo sapiens	153-157
16800690-3	2006	In this report, we were able to directly monitor single BODIPY 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine (DHPE) and ryanodine receptor type 2 (RyR2) labeled with Cy5 molecules in lipid bilayers containing phosphatidylserine (PS) by using fluorescence microscopy.	Phosphatidylserines	235-237	ryanodine receptor 2	Homo sapiens	153-157
16759634-9	2006	Besides, the modified peptides were also comparable to peptide F3,6,14,18 18A in restoring phosphatidylserine-induced loss of PON1 activity.	Phosphatidylserines	91-109	paraoxonase 1	Homo sapiens	126-130
16799980-5	2006	In a mouse model for PFIC1, we observed decreased resistance of the hepatocanalicular membrane to hydrophobic bile salts as evidenced by enhanced biliary recovery of phosphatidylserine, cholesterol, and ectoenzymes.	Phosphatidylserines	166-184	ATPase phospholipid transporting 8B1	Homo sapiens	21-26
16799018-5	2006	P2X7 cell death receptor activation was evaluated using the YO-PRO-1 assay and apoptosis (chromatin condensation and translocation of phosphatidylserine) using the Hoechst 33342 and annexin V-FITC dyes.	Phosphatidylserines	134-152	purinergic receptor P2X 7	Homo sapiens	0-4
16839352-12	2006	In addition, annexin V, which blocks PS binding sites, inhibited FX and prothrombin conversion by their respective C6-assembled activating complexes.	Phosphatidylserines	37-39	annexin A5	Rattus norvegicus	13-22
16530182-3	2006	Although SR-BI directly binds to PS present on the surface of apoptotic cells, as to whether SR-BI transmits signals to induce engulfment has not been clear.	Phosphatidylserines	33-35	scavenger receptor class B, member 1	Rattus norvegicus	9-14
16530182-5	2006	The chemical compound inhibited the incorporation of HDL lipids and PS-containing liposomes by an SR-BI-expressing culture cell line, with no effect on the binding of these targets.	Phosphatidylserines	68-70	scavenger receptor class B, member 1	Rattus norvegicus	98-103
16530182-7	2006	The addition of apoptotic cells or PS-containing liposomes caused a temporal increment of the phosphorylation of all three mitogen-activated protein kinases, p38, extracellular-signal-regulated kinase (ERK) and c-Jun amino-terminal kinase (JNK), in Sertoli cells.	Phosphatidylserines	35-37	mitogen activated protein kinase 14	Rattus norvegicus	158-161
16530182-7	2006	The addition of apoptotic cells or PS-containing liposomes caused a temporal increment of the phosphorylation of all three mitogen-activated protein kinases, p38, extracellular-signal-regulated kinase (ERK) and c-Jun amino-terminal kinase (JNK), in Sertoli cells.	Phosphatidylserines	35-37	Eph receptor B1	Rattus norvegicus	163-200
16530182-7	2006	The addition of apoptotic cells or PS-containing liposomes caused a temporal increment of the phosphorylation of all three mitogen-activated protein kinases, p38, extracellular-signal-regulated kinase (ERK) and c-Jun amino-terminal kinase (JNK), in Sertoli cells.	Phosphatidylserines	35-37	Eph receptor B1	Rattus norvegicus	202-205
16530182-9	2006	Furthermore, the level of Sertoli cell phagocytosis of PS-exposing apoptotic cells, as well as that of PS-containing liposomes, was reduced only when the actions of p38 and ERK were simultaneously repressed.	Phosphatidylserines	55-57	mitogen activated protein kinase 14	Rattus norvegicus	165-168
16530182-9	2006	Furthermore, the level of Sertoli cell phagocytosis of PS-exposing apoptotic cells, as well as that of PS-containing liposomes, was reduced only when the actions of p38 and ERK were simultaneously repressed.	Phosphatidylserines	55-57	Eph receptor B1	Rattus norvegicus	173-176
16520488-6	2006	Thus, DCP-LA serves as a selective activator of PKC-epsilon, possibly by binding to the phosphatidylserine binding site on PKC-epsilon.	Phosphatidylserines	88-106	protein kinase C epsilon	Homo sapiens	48-59
16520488-6	2006	Thus, DCP-LA serves as a selective activator of PKC-epsilon, possibly by binding to the phosphatidylserine binding site on PKC-epsilon.	Phosphatidylserines	88-106	protein kinase C epsilon	Homo sapiens	123-134
16828307-11	2006	This assay detects ATP-dependent translocation of labeled phosphatidylserine across late Golgi membranes, which requires the activity of a P-type ATPase called Drs2p [P. Natarajan, J. Wang, Z. Hua, T.R.	Phosphatidylserines	58-76	aminophospholipid-translocating P4-type ATPase DRS2	Saccharomyces cerevisiae S288C	160-165
16688342-2	2006	The most common method of detecting PS on a cell surface is to use the protein annexin V; however, in certain applications there is a need for alternative reagents.	Phosphatidylserines	36-38	annexin A5	Homo sapiens	79-88
16740248-2	2006	Recently, two additional essential functions of cyt c in apoptosis have been discovered that are carried out via its interactions with anionic phospholipids: a mitochondria specific phospholipid, cardiolipin (CL), and plasma membrane phosphatidylserine (PS).	Phosphatidylserines	234-252	cytochrome c, somatic	Homo sapiens	48-53
16740248-9	2006	In the cytosol, released cyt c interacts with another anionic phospholipid, PS, and catalyzes its oxidation in a similar oxygenase reaction.	Phosphatidylserines	76-78	cytochrome c, somatic	Homo sapiens	25-30
16740248-11	2006	Redox catalysis of plasma membrane PS oxidation constitutes an important redox-dependent function of cyt c in apoptosis and phagocytosis.	Phosphatidylserines	35-37	cytochrome c, somatic	Homo sapiens	101-106
16618126-6	2006	The purified Atp8a1 is inactive in detergent micelles or in micelles containing phosphatidylcholine, phosphatidic acid, or phosphatidylinositol, is minimally activated by phosphatidylglycerol or phosphatidylethanolamine (PE), and is maximally activated by PS.	Phosphatidylserines	256-258	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	Mus musculus	13-19
16618126-8	2006	Similar to the plasma membrane PS transporter, Atp8a1 is activated only by the naturally occurring sn-1,2-glycerol isomer of PS and not the sn-2,3-glycerol stereoisomer.	Phosphatidylserines	31-33	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	Mus musculus	47-53
16500904-7	2006	ABCA1 showed lower ATPase activity when reconstituted in liposomes containing phosphatidylserine, phosphatidylethanolamine, or phosphatidylglycerol and also showed weak specificity in acyl chain species.	Phosphatidylserines	78-96	ATP binding cassette subfamily A member 1	Homo sapiens	0-5
16500904-7	2006	ABCA1 showed lower ATPase activity when reconstituted in liposomes containing phosphatidylserine, phosphatidylethanolamine, or phosphatidylglycerol and also showed weak specificity in acyl chain species.	Phosphatidylserines	78-96	dynein axonemal heavy chain 8	Homo sapiens	19-25
16401186-6	2006	Total MFG-E8 in milk was also increased in the post-weaning mammary glands and, furthermore, the free MFG-E8 content in the post-weaning milk, as measured by in vitro PS-binding and apoptotic HC11 cell-binding activities, was much higher than that of lactation.	Phosphatidylserines	167-169	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	6-12
16401186-8	2006	Sucrose density-gradient ultracentrifugation analyses revealed that such enhanced PS-binding activity of MFG-E8 was present in membrane vesicle fractions (density 1.05-1.13 g/ml), rather than milk fat globule fractions.	Phosphatidylserines	82-84	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	105-111
16437546-8	2006	Therefore, we carried out experiments for immunolabeling PS molecules with fluorescein isothiocyanate (FITC)-conjugated Annexin V on exposed cells.	Phosphatidylserines	57-59	annexin A5	Homo sapiens	120-129
16674912-6	2006	In contrast, phosphatidylserine and phosphatidic acid (&gt; or =0.1 mM) inhibited both activities Further, such a preferable stimulation of arylesterase activity by phosphatidylcholines was also reproduced with VLDL-bound PON1, although to a less extent.	Phosphatidylserines	13-31	paraoxonase 1	Homo sapiens	222-226
16512832-3	2006	The current study demonstrated that anti-GPIIb injection induced three critical apoptosis manifestations in platelets: (i) mitochondrial inner transmembrane potential (delta psi m) depolarisation; (ii) caspase-3 activation; and (iii) phosphatidylserine (PS) exposure.	Phosphatidylserines	234-252	integrin alpha 2b	Mus musculus	41-46
16503408-1	2006	Recently, it has been observed that Annexin V labelling of phosphatidylserine (PS) on non-apoptotic cells can vary in different leukocyte populations and with the activation of cells, due to differences in the absolute level of exposed PS.	Phosphatidylserines	59-77	annexin A5	Homo sapiens	36-45
16503408-1	2006	Recently, it has been observed that Annexin V labelling of phosphatidylserine (PS) on non-apoptotic cells can vary in different leukocyte populations and with the activation of cells, due to differences in the absolute level of exposed PS.	Phosphatidylserines	79-81	annexin A5	Homo sapiens	36-45
16380116-9	2006	Interestingly, cells with internalized annexin A5 still express PS at their surface.	Phosphatidylserines	64-66	annexin A5	Homo sapiens	39-49
16452632-4	2006	Removal of P4 ATPases Dnf1p and Dnf2p from budding yeast abolishes inward translocation of 6-[(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminocaproyl] (NBD)-labeled PS, PE, and phosphatidylcholine (PC) across the plasma membrane and causes cell surface exposure of endogenous PE.	Phosphatidylserines	157-159	aminophospholipid-translocating P4-type ATPase DNF1	Saccharomyces cerevisiae S288C	22-27
16452632-4	2006	Removal of P4 ATPases Dnf1p and Dnf2p from budding yeast abolishes inward translocation of 6-[(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminocaproyl] (NBD)-labeled PS, PE, and phosphatidylcholine (PC) across the plasma membrane and causes cell surface exposure of endogenous PE.	Phosphatidylserines	157-159	aminophospholipid-translocating P4-type ATPase DNF2	Saccharomyces cerevisiae S288C	32-37
16954025-3	2006	Annexin V, a protein with high specificity and tight binding to PS, was used to identify and localize apoptosis in the ischemic heart.Fluorescein-labeled annexin V has been used routinely for the assessment of apoptosis in vitro.	Phosphatidylserines	64-66	annexin A5	Rattus norvegicus	0-9
16954025-3	2006	Annexin V, a protein with high specificity and tight binding to PS, was used to identify and localize apoptosis in the ischemic heart.Fluorescein-labeled annexin V has been used routinely for the assessment of apoptosis in vitro.	Phosphatidylserines	64-66	annexin A5	Rattus norvegicus	154-163
16361709-1	2006	Protein kinase C (PKC) delta is regulated allosterically by phosphatidylserine and diacylglycerol (which promote its translocation to the membrane) and by phosphorylation of Ser/Thr and Tyr residues.	Phosphatidylserines	60-78	protein kinase C delta	Homo sapiens	0-28
16445995-0	2006	Interactions of chromogranin A-derived vasostatins and monolayers of phosphatidylserine, phosphatidylcholine and phosphatidylethanolamine.	Phosphatidylserines	69-87	chromogranin A	Sus scrofa	16-30
16519527-10	2006	We propose that redistribution of PS is dependent on an increase in phospholipid scramblase activity and a decrease in APLT activity.	Phosphatidylserines	34-36	ATPase, class I, type 8B, member 1	Mus musculus	119-123
16483923-2	2006	They are frequently associated with antiphospholipid Ab (aPL), binding to complexes of phosphatidylserine (PS) with beta2GPI.	Phosphatidylserines	87-105	apolipoprotein H	Mus musculus	116-124
16483923-2	2006	They are frequently associated with antiphospholipid Ab (aPL), binding to complexes of phosphatidylserine (PS) with beta2GPI.	Phosphatidylserines	107-109	apolipoprotein H	Mus musculus	116-124
16627002-1	2006	Phosphatidylserine (PS) is synthesized in mammalian cells by two distinct serine-exchange enzymes, phosphatidylserine synthase-1 and -2.	Phosphatidylserines	0-18	phosphatidylserine synthase 1	Homo sapiens	99-135
16627002-1	2006	Phosphatidylserine (PS) is synthesized in mammalian cells by two distinct serine-exchange enzymes, phosphatidylserine synthase-1 and -2.	Phosphatidylserines	20-22	phosphatidylserine synthase 1	Homo sapiens	99-135
16339168-4	2006	RESULTS: The annexin V binding assay in sperm of patients with chromosomal translocation (n=17) showed a significantly increased proportion of sperm with externalized phosphatidylserine (PS) than in the control group (n=20, P&lt;or=0.05).	Phosphatidylserines	167-185	annexin A5	Homo sapiens	13-22
16371234-8	2006	On the other hand, mPGES-2 and cytosolic PGES (cPGES) that are functionally coupled with COX-1 were upregulated after treatment with PS liposomes or LPS.	Phosphatidylserines	133-135	prostaglandin E synthase 2	Mus musculus	19-26
16371234-8	2006	On the other hand, mPGES-2 and cytosolic PGES (cPGES) that are functionally coupled with COX-1 were upregulated after treatment with PS liposomes or LPS.	Phosphatidylserines	133-135	prostaglandin E synthase 3	Rattus norvegicus	31-45
16371234-8	2006	On the other hand, mPGES-2 and cytosolic PGES (cPGES) that are functionally coupled with COX-1 were upregulated after treatment with PS liposomes or LPS.	Phosphatidylserines	133-135	prostaglandin E synthase 3	Rattus norvegicus	47-52
16371234-8	2006	On the other hand, mPGES-2 and cytosolic PGES (cPGES) that are functionally coupled with COX-1 were upregulated after treatment with PS liposomes or LPS.	Phosphatidylserines	133-135	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	89-94
16371234-9	2006	Furthermore, PS liposome-induced PGE2 production was significantly suppressed by indomethacin, a preferential COX-1 inhibitor, but not by NS-398, a selective COX-2 inhibitor.	Phosphatidylserines	13-15	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	110-115
16492791-5	2006	We found that the myo1c-tail binds tightly to LUVs containing &gt;60% PS but very weakly to LUVs containing physiological PS concentrations (&lt;40%).	Phosphatidylserines	70-72	myosin IC	Homo sapiens	18-23
16492791-5	2006	We found that the myo1c-tail binds tightly to LUVs containing &gt;60% PS but very weakly to LUVs containing physiological PS concentrations (&lt;40%).	Phosphatidylserines	122-124	myosin IC	Homo sapiens	18-23
16259620-4	2006	CA-C had a greater affinity for negatively charged lipids (phosphatidic acid and phosphatidylserine) than for zwitterionic lipids [PC/Cho/SM (equimolar mixture of phosphatidylcholine, cholesterol and sphingomyelin) and phosphatidylcholine].	Phosphatidylserines	81-99	carbonic anhydrase 2	Homo sapiens	0-4
16303767-0	2006	Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16.	Phosphatidylserines	0-18	GABA type A receptor associated protein like 2	Homo sapiens	98-102
16303767-0	2006	Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16.	Phosphatidylserines	0-18	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	114-117
16303767-0	2006	Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16.	Phosphatidylserines	0-18	GABA type A receptor-associated protein	Homo sapiens	119-126
16303767-0	2006	Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16.	Phosphatidylserines	0-18	GABA type A receptor associated protein like 2	Homo sapiens	132-139
16303767-8	2006	In addition to phosphatidylethanolamine, in vitro conjugation experiments using synthetic phospholipid liposomes showed that phosphatidylserine is also a target of LC3, GABARAP, and GATE-16.	Phosphatidylserines	125-143	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	164-167
16303767-8	2006	In addition to phosphatidylethanolamine, in vitro conjugation experiments using synthetic phospholipid liposomes showed that phosphatidylserine is also a target of LC3, GABARAP, and GATE-16.	Phosphatidylserines	125-143	GABA type A receptor-associated protein	Homo sapiens	169-176
16303767-8	2006	In addition to phosphatidylethanolamine, in vitro conjugation experiments using synthetic phospholipid liposomes showed that phosphatidylserine is also a target of LC3, GABARAP, and GATE-16.	Phosphatidylserines	125-143	GABA type A receptor associated protein like 2	Homo sapiens	182-189
16459021-5	2006	Incubation of PBMCs with 5 mM H2O2 led to increased Annexin-V binding to externalized phosphatidyl serine (PS), an event of pre-apoptotic stage of the cell.	Phosphatidylserines	86-105	annexin A5	Homo sapiens	52-61
16459021-5	2006	Incubation of PBMCs with 5 mM H2O2 led to increased Annexin-V binding to externalized phosphatidyl serine (PS), an event of pre-apoptotic stage of the cell.	Phosphatidylserines	107-109	annexin A5	Homo sapiens	52-61
16459134-3	2006	PS exposure induced in human platelets by thrombin, TRAP, collagen or TRAP+ collagen was abolished in a Na+ -free medium.	Phosphatidylserines	0-2	coagulation factor II, thrombin	Homo sapiens	42-50
16459134-3	2006	PS exposure induced in human platelets by thrombin, TRAP, collagen or TRAP+ collagen was abolished in a Na+ -free medium.	Phosphatidylserines	0-2	TRAP	Homo sapiens	52-56
16459134-3	2006	PS exposure induced in human platelets by thrombin, TRAP, collagen or TRAP+ collagen was abolished in a Na+ -free medium.	Phosphatidylserines	0-2	TRAP	Homo sapiens	70-74
16195337-8	2006	The sTF-annexin V chimera is a targeted procoagulant protein that may be useful in accelerating thrombin generation where PS is exposed to the vasculature, such as may occur at sites of vascular injury or within the vasculature of tumors.	Phosphatidylserines	122-124	annexin A5	Homo sapiens	8-17
16195337-8	2006	The sTF-annexin V chimera is a targeted procoagulant protein that may be useful in accelerating thrombin generation where PS is exposed to the vasculature, such as may occur at sites of vascular injury or within the vasculature of tumors.	Phosphatidylserines	122-124	coagulation factor II, thrombin	Homo sapiens	96-104
16249245-8	2006	RESULTS: Our studies found that human and murine neutrophils carrying the gp91 form of chronic granulomatous disease had impaired exposure of phosphatidyl serine on the surface.	Phosphatidylserines	142-161	paired Ig-like receptor B	Mus musculus	74-78
16278219-2	2006	We hypothesized that sPLA(2) will hydrolyze red blood cells that expose phosphatidylserine (PS) and generate lysophosphatidic acid (LPA) from phosphatidic acid that is elevated in PS-exposing red blood cells.	Phosphatidylserines	72-90	phospholipase A2 group IIA	Rattus norvegicus	21-28
16278219-2	2006	We hypothesized that sPLA(2) will hydrolyze red blood cells that expose phosphatidylserine (PS) and generate lysophosphatidic acid (LPA) from phosphatidic acid that is elevated in PS-exposing red blood cells.	Phosphatidylserines	92-94	phospholipase A2 group IIA	Rattus norvegicus	21-28
16146427-3	2006	Here we show that human LOX-1 recognizes a key cellular phospholipid, PS (phosphatidylserine), in a Ca2+-dependent manner, both in vitro and in cultured cells.	Phosphatidylserines	70-72	oxidized low density lipoprotein receptor 1	Homo sapiens	24-29
16146427-3	2006	Here we show that human LOX-1 recognizes a key cellular phospholipid, PS (phosphatidylserine), in a Ca2+-dependent manner, both in vitro and in cultured cells.	Phosphatidylserines	74-92	oxidized low density lipoprotein receptor 1	Homo sapiens	24-29
16146427-4	2006	A recombinant, folded and glycosylated LOX-1 molecule binds PS, but not other phospholipids.	Phosphatidylserines	60-62	oxidized low density lipoprotein receptor 1	Homo sapiens	39-44
16146427-5	2006	LOX-1 recognition of PS was maximal in the presence of millimolar Ca2+ levels.	Phosphatidylserines	21-23	oxidized low density lipoprotein receptor 1	Homo sapiens	0-5
16146427-7	2006	LOX-1-mediated recognition of PS-containing apoptotic bodies was dependent on Ca2+ and was decreased to background levels by bivalent-cation chelation, LOX-1-blocking antibodies or PS-containing liposomes.	Phosphatidylserines	30-32	oxidized low density lipoprotein receptor 1	Homo sapiens	0-5
16146427-7	2006	LOX-1-mediated recognition of PS-containing apoptotic bodies was dependent on Ca2+ and was decreased to background levels by bivalent-cation chelation, LOX-1-blocking antibodies or PS-containing liposomes.	Phosphatidylserines	30-32	oxidized low density lipoprotein receptor 1	Homo sapiens	152-157
16146427-7	2006	LOX-1-mediated recognition of PS-containing apoptotic bodies was dependent on Ca2+ and was decreased to background levels by bivalent-cation chelation, LOX-1-blocking antibodies or PS-containing liposomes.	Phosphatidylserines	181-183	oxidized low density lipoprotein receptor 1	Homo sapiens	0-5
16679769-3	2006	PS can be decarboxylated to PE, and PC is synthesized from PE by phosphatidylethanolamine N-methyltransferase (PEMT).	Phosphatidylserines	0-2	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	111-115
16055348-4	2006	Then a novel purification method based on Ca2+-dependent phosphatidylserine (PS)-binding activity was established, whereby the purity of rh-annexin A5 was increased to 98%.	Phosphatidylserines	57-75	annexin A5	Homo sapiens	140-150
16055348-4	2006	Then a novel purification method based on Ca2+-dependent phosphatidylserine (PS)-binding activity was established, whereby the purity of rh-annexin A5 was increased to 98%.	Phosphatidylserines	77-79	annexin A5	Homo sapiens	140-150
16243846-4	2005	In vitro measurements showed that hSK1 selectively bound phosphatidylserine over other anionic phospholipids and strongly preferred the plasma membrane-mimicking membrane to other cellular membrane mimetics.	Phosphatidylserines	57-75	sphingosine kinase 1	Homo sapiens	34-38
16289110-2	2005	Phosphatidylserine (PS), which has a negatively charged head group, completely inhibited IFN-gamma production in splenic naive T cells and antigen-dependent IFN-gamma production in Th1 clone 42-6A cells, whereas other phospholipids, which have neutrally charged head group, had no effect.	Phosphatidylserines	0-18	interferon gamma	Mus musculus	89-98
16289110-2	2005	Phosphatidylserine (PS), which has a negatively charged head group, completely inhibited IFN-gamma production in splenic naive T cells and antigen-dependent IFN-gamma production in Th1 clone 42-6A cells, whereas other phospholipids, which have neutrally charged head group, had no effect.	Phosphatidylserines	0-18	interferon gamma	Mus musculus	157-166
16289110-2	2005	Phosphatidylserine (PS), which has a negatively charged head group, completely inhibited IFN-gamma production in splenic naive T cells and antigen-dependent IFN-gamma production in Th1 clone 42-6A cells, whereas other phospholipids, which have neutrally charged head group, had no effect.	Phosphatidylserines	20-22	interferon gamma	Mus musculus	89-98
16289110-2	2005	Phosphatidylserine (PS), which has a negatively charged head group, completely inhibited IFN-gamma production in splenic naive T cells and antigen-dependent IFN-gamma production in Th1 clone 42-6A cells, whereas other phospholipids, which have neutrally charged head group, had no effect.	Phosphatidylserines	20-22	interferon gamma	Mus musculus	157-166
16254207-7	2005	In both venules and arterioles, signaling through GPVI, FcR gamma-chain, and Src kinases enhanced the formation of phosphatidylserine-exposing and fibrin-rich thrombi.	Phosphatidylserines	115-133	glycoprotein 6 (platelet)	Mus musculus	50-54
16254207-7	2005	In both venules and arterioles, signaling through GPVI, FcR gamma-chain, and Src kinases enhanced the formation of phosphatidylserine-exposing and fibrin-rich thrombi.	Phosphatidylserines	115-133	Fc receptor, IgE, high affinity I, gamma polypeptide	Mus musculus	56-65
16254207-7	2005	In both venules and arterioles, signaling through GPVI, FcR gamma-chain, and Src kinases enhanced the formation of phosphatidylserine-exposing and fibrin-rich thrombi.	Phosphatidylserines	115-133	Rous sarcoma oncogene	Mus musculus	77-80
16299185-11	2005	Autophosphorylation of GST-ZmCPK11 was stimulated by calcium and by phosphatidic acid and, to a lesser extent, by phosphatidylserine.	Phosphatidylserines	114-132	glutathione S-transferase	Zea mays	23-26
16362078-5	2005	Flow cytometric analysis to detect annexin V binding to phosphatidylserine demonstrated that DHC increased apoptosis more than 3-fold over controls.	Phosphatidylserines	56-74	annexin A5	Homo sapiens	35-44
16411400-6	2005	Flow cytometry revealed that this discrepancy between TF activity and TF expression at endotoxin concentrations above 1 ng/ml, coincided with an LPS dose-dependent increase in cell surface phosphatidylserine (PS), considered to promote coagulation.	Phosphatidylserines	189-207	coagulation factor III, tissue factor	Homo sapiens	54-56
16411400-6	2005	Flow cytometry revealed that this discrepancy between TF activity and TF expression at endotoxin concentrations above 1 ng/ml, coincided with an LPS dose-dependent increase in cell surface phosphatidylserine (PS), considered to promote coagulation.	Phosphatidylserines	189-207	coagulation factor III, tissue factor	Homo sapiens	70-72
16269280-3	2005	Here, we analyzed the interaction of NK-2 with normal human lymphocytes and seven different human cancer cell lines and demonstrate that some of these cells expose negatively charged surface phosphatidylserine (PS), which presumably facilitates killing of the cells by NK-2.	Phosphatidylserines	191-209	NK2 homeobox 1	Homo sapiens	37-41
16269280-3	2005	Here, we analyzed the interaction of NK-2 with normal human lymphocytes and seven different human cancer cell lines and demonstrate that some of these cells expose negatively charged surface phosphatidylserine (PS), which presumably facilitates killing of the cells by NK-2.	Phosphatidylserines	191-209	NK2 homeobox 1	Homo sapiens	269-273
16269280-3	2005	Here, we analyzed the interaction of NK-2 with normal human lymphocytes and seven different human cancer cell lines and demonstrate that some of these cells expose negatively charged surface phosphatidylserine (PS), which presumably facilitates killing of the cells by NK-2.	Phosphatidylserines	211-213	NK2 homeobox 1	Homo sapiens	37-41
16269280-3	2005	Here, we analyzed the interaction of NK-2 with normal human lymphocytes and seven different human cancer cell lines and demonstrate that some of these cells expose negatively charged surface phosphatidylserine (PS), which presumably facilitates killing of the cells by NK-2.	Phosphatidylserines	211-213	NK2 homeobox 1	Homo sapiens	269-273
16184625-6	2005	We show, in non-apoptotic C2C12 cells, that relocation of an exogenous PS analogue, from the outer into the inner leaflet, is accelerated by IGF-1 in a concentration-dependent manner and that maintenance of membrane asymmetry triggered by IGF-1 is however independent of the PI3K inhibitor wortmannin.	Phosphatidylserines	71-73	insulin-like growth factor 1	Mus musculus	141-146
16184625-6	2005	We show, in non-apoptotic C2C12 cells, that relocation of an exogenous PS analogue, from the outer into the inner leaflet, is accelerated by IGF-1 in a concentration-dependent manner and that maintenance of membrane asymmetry triggered by IGF-1 is however independent of the PI3K inhibitor wortmannin.	Phosphatidylserines	71-73	insulin-like growth factor 1	Mus musculus	239-244
20641799-6	2004	At this stage, Annexin V (36 kDa; 10-(10) &lt; Kd &lt; 10-(9)m (3)) may be used to recognize the surface- exposed PS by strongly and specifically binding to the phospholipid, reflecting a biological role as an anti-coagulant (4-6).	Phosphatidylserines	114-116	annexin A5	Homo sapiens	15-24
16120614-2	2005	In this study, we report another class of carrier proteins, termed Serinc1-5, that incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids.	Phosphatidylserines	197-215	serine incorporator 1	Rattus norvegicus	67-76
16093350-3	2005	We found that different isoforms of syt couple distinct ranges of Ca2+, Ba2+, and Sr2+ to membrane fusion; syt VII was approximately 400-fold more sensitive to Ca2+ than was syt I. Omission of phosphatidylserine (PS) from both populations of liposomes completely abrogated the ability of all three isoforms of syt to stimulate fusion.	Phosphatidylserines	193-211	synaptotagmin 1	Homo sapiens	36-39
16093350-3	2005	We found that different isoforms of syt couple distinct ranges of Ca2+, Ba2+, and Sr2+ to membrane fusion; syt VII was approximately 400-fold more sensitive to Ca2+ than was syt I. Omission of phosphatidylserine (PS) from both populations of liposomes completely abrogated the ability of all three isoforms of syt to stimulate fusion.	Phosphatidylserines	193-211	synaptotagmin 7	Homo sapiens	107-114
16093350-6	2005	Our data demonstrate that different syt isoforms are specialized to sense different ranges of divalent cations and that PS is an essential effector of Ca2+.syt action.	Phosphatidylserines	120-122	synaptotagmin 1	Homo sapiens	36-39
16093350-6	2005	Our data demonstrate that different syt isoforms are specialized to sense different ranges of divalent cations and that PS is an essential effector of Ca2+.syt action.	Phosphatidylserines	120-122	synaptotagmin 1	Homo sapiens	156-159
16156665-3	2005	The apparent rates of phospholipid hydrolysis by the sPLA(2)s tested vary by up to 4 orders of magnitude, and all enzymes display a strong preference for vesicles containing anionic phospholipids, phosphatidylglycerol or phosphatidylserine (PS), over those containing zwitterionic phosphatidylcholine (PC).	Phosphatidylserines	221-239	phospholipase A2 group IID	Homo sapiens	53-61
16156665-3	2005	The apparent rates of phospholipid hydrolysis by the sPLA(2)s tested vary by up to 4 orders of magnitude, and all enzymes display a strong preference for vesicles containing anionic phospholipids, phosphatidylglycerol or phosphatidylserine (PS), over those containing zwitterionic phosphatidylcholine (PC).	Phosphatidylserines	241-243	phospholipase A2 group IID	Homo sapiens	53-61
16142909-4	2005	In the presence of membranes containing negatively charged phosphatidylserine (PS), we observed significant acceleration in the formation of IAPP aggregates.	Phosphatidylserines	59-77	islet amyloid polypeptide	Homo sapiens	141-145
16142924-4	2005	Using a freeze-thaw procedure, purified rOCT1 was reconstituted into proteoliposomes formed from phosphatidylcholine, phosphatidylserine, and cholesterol.	Phosphatidylserines	118-136	solute carrier family 22 member 1	Rattus norvegicus	40-45
16020543-8	2005	The binding of alpha-synuclein to these raft-like liposomes requires acidic phospholipids, with a preference for phosphatidylserine (PS).	Phosphatidylserines	113-131	synuclein alpha	Homo sapiens	15-30
16020543-8	2005	The binding of alpha-synuclein to these raft-like liposomes requires acidic phospholipids, with a preference for phosphatidylserine (PS).	Phosphatidylserines	133-135	synuclein alpha	Homo sapiens	15-30
16020543-10	2005	Rather, the interaction with alpha-synuclein requires a combination of PS with oleic (18:1) and polyunsaturated (either 20:4 or 22:6) fatty acyl chains, suggesting a role for phase separation within the membrane.	Phosphatidylserines	71-73	synuclein alpha	Homo sapiens	29-44
16051265-1	2005	We show that human wild-type alpha synuclein (WT alpha-syn), and the inherited mutants A53T or A30P, when expressed in the yeast Saccharomyces cerevisiae triggers events that are diagnostic of apoptosis: loss of membrane asymmetry due to the externalization of phosphatidylserine, accumulation of reactive oxygen species (ROS), and the release of cytochrome c from mitochondria.	Phosphatidylserines	261-279	synuclein alpha	Homo sapiens	49-58
15914007-4	2005	The consequent appearance of PS on the extracellular membrane leaflet is commonly monitored using dye-labeled Annexin V, a 36 kDa, Ca2+-dependent PS binding protein.	Phosphatidylserines	29-31	annexin A5	Homo sapiens	110-119
15914007-4	2005	The consequent appearance of PS on the extracellular membrane leaflet is commonly monitored using dye-labeled Annexin V, a 36 kDa, Ca2+-dependent PS binding protein.	Phosphatidylserines	146-148	annexin A5	Homo sapiens	110-119
15914007-5	2005	Substitutes for Annexin V are described, including small molecules, nanoparticles, cationic liposomes, and other proteins that can recognize PS in a membrane surface.	Phosphatidylserines	141-143	annexin A5	Homo sapiens	16-25
15982908-4	2005	MFG-E8 has two domains: an Arg-Gly-Asp sequence that binds integrins alphavbeta3 and alphavbeta5 (expressed by human DCs and macrophages) and a phosphatidyl-serine (PS) binding sequence through which it associates to PS-containing membranes (among which exosomes).	Phosphatidylserines	144-163	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	0-6
15982908-4	2005	MFG-E8 has two domains: an Arg-Gly-Asp sequence that binds integrins alphavbeta3 and alphavbeta5 (expressed by human DCs and macrophages) and a phosphatidyl-serine (PS) binding sequence through which it associates to PS-containing membranes (among which exosomes).	Phosphatidylserines	165-167	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	0-6
15982908-4	2005	MFG-E8 has two domains: an Arg-Gly-Asp sequence that binds integrins alphavbeta3 and alphavbeta5 (expressed by human DCs and macrophages) and a phosphatidyl-serine (PS) binding sequence through which it associates to PS-containing membranes (among which exosomes).	Phosphatidylserines	217-219	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	0-6
16023863-1	2005	Low-energy CAD product-ion spectra of various molecular species of phosphatidylserine (PS) in the forms of [M-H]- and [M-2H+Alk]- in the negative-ion mode, as well as in the forms of [M+H]+, [M+Alk]+, [M-H+2Alk]+, and [M-2H+3Alk]+ (where Alk=Li, Na) in the positive-ion mode contain rich fragment ions that are applicable for structural determination.	Phosphatidylserines	67-85	ALK receptor tyrosine kinase	Homo sapiens	124-127
16023863-1	2005	Low-energy CAD product-ion spectra of various molecular species of phosphatidylserine (PS) in the forms of [M-H]- and [M-2H+Alk]- in the negative-ion mode, as well as in the forms of [M+H]+, [M+Alk]+, [M-H+2Alk]+, and [M-2H+3Alk]+ (where Alk=Li, Na) in the positive-ion mode contain rich fragment ions that are applicable for structural determination.	Phosphatidylserines	67-85	ALK receptor tyrosine kinase	Homo sapiens	194-197
16023863-1	2005	Low-energy CAD product-ion spectra of various molecular species of phosphatidylserine (PS) in the forms of [M-H]- and [M-2H+Alk]- in the negative-ion mode, as well as in the forms of [M+H]+, [M+Alk]+, [M-H+2Alk]+, and [M-2H+3Alk]+ (where Alk=Li, Na) in the positive-ion mode contain rich fragment ions that are applicable for structural determination.	Phosphatidylserines	67-85	ALK receptor tyrosine kinase	Homo sapiens	194-197
16023863-1	2005	Low-energy CAD product-ion spectra of various molecular species of phosphatidylserine (PS) in the forms of [M-H]- and [M-2H+Alk]- in the negative-ion mode, as well as in the forms of [M+H]+, [M+Alk]+, [M-H+2Alk]+, and [M-2H+3Alk]+ (where Alk=Li, Na) in the positive-ion mode contain rich fragment ions that are applicable for structural determination.	Phosphatidylserines	87-89	ALK receptor tyrosine kinase	Homo sapiens	124-127
16023863-1	2005	Low-energy CAD product-ion spectra of various molecular species of phosphatidylserine (PS) in the forms of [M-H]- and [M-2H+Alk]- in the negative-ion mode, as well as in the forms of [M+H]+, [M+Alk]+, [M-H+2Alk]+, and [M-2H+3Alk]+ (where Alk=Li, Na) in the positive-ion mode contain rich fragment ions that are applicable for structural determination.	Phosphatidylserines	87-89	ALK receptor tyrosine kinase	Homo sapiens	194-197
16023863-1	2005	Low-energy CAD product-ion spectra of various molecular species of phosphatidylserine (PS) in the forms of [M-H]- and [M-2H+Alk]- in the negative-ion mode, as well as in the forms of [M+H]+, [M+Alk]+, [M-H+2Alk]+, and [M-2H+3Alk]+ (where Alk=Li, Na) in the positive-ion mode contain rich fragment ions that are applicable for structural determination.	Phosphatidylserines	87-89	ALK receptor tyrosine kinase	Homo sapiens	194-197
16114872-5	2005	However, atRA had a biphasic effect on PKCalpha activity in the presence of activating phospholipids, such as phosphatidylserine and phosphatidylinositol 4,5-bisphosphate, yielding activation at low concentrations but inactivation at higher ones.	Phosphatidylserines	110-128	protein kinase C alpha	Homo sapiens	39-47
16114872-9	2005	It was concluded that whereas atRA may activate PKCalpha through the Ca(2+)-phosphatidylserine-binding site of the C2 domain, it may also inhibit the activity of this enzyme when displacing the phospholipid from the Lys-rich cluster also located in the C2 domain.	Phosphatidylserines	76-94	protein kinase C alpha	Homo sapiens	48-56
15929990-3	2005	We asked whether dGal-1 initiated Ca(2+) fluxes that are required to redistribute PS to the surface of activated neutrophils.	Phosphatidylserines	82-84	Galactose-specific C-type lectin	Drosophila melanogaster	17-23
15929990-4	2005	Prolonged occupancy by dGal-1 was required to maximally mobilize PS to the surfaces of fMLP-activated neutrophils.	Phosphatidylserines	65-67	Galactose-specific C-type lectin	Drosophila melanogaster	23-29
15929990-4	2005	Prolonged occupancy by dGal-1 was required to maximally mobilize PS to the surfaces of fMLP-activated neutrophils.	Phosphatidylserines	65-67	formyl peptide receptor 1	Homo sapiens	87-91
15929990-10	2005	dGal-1 elevated cytosolic Ca(2+) and mobilized PS through a pathway that required action of Src kinases and phospholipase Cgamma.	Phosphatidylserines	47-49	Galactose-specific C-type lectin	Drosophila melanogaster	0-6
15967578-1	2005	Phosphatidylserine (PS) plays a crucial role, in the conversion of prothrombin into thrombin by the protease, factor Xa.	Phosphatidylserines	0-18	coagulation factor II, thrombin	Homo sapiens	67-78
15967578-1	2005	Phosphatidylserine (PS) plays a crucial role, in the conversion of prothrombin into thrombin by the protease, factor Xa.	Phosphatidylserines	0-18	coagulation factor II, thrombin	Homo sapiens	70-78
15967578-1	2005	Phosphatidylserine (PS) plays a crucial role, in the conversion of prothrombin into thrombin by the protease, factor Xa.	Phosphatidylserines	0-18	coagulation factor X	Homo sapiens	110-119
15967578-1	2005	Phosphatidylserine (PS) plays a crucial role, in the conversion of prothrombin into thrombin by the protease, factor Xa.	Phosphatidylserines	20-22	coagulation factor II, thrombin	Homo sapiens	67-78
15967578-1	2005	Phosphatidylserine (PS) plays a crucial role, in the conversion of prothrombin into thrombin by the protease, factor Xa.	Phosphatidylserines	20-22	coagulation factor II, thrombin	Homo sapiens	70-78
15967578-1	2005	Phosphatidylserine (PS) plays a crucial role, in the conversion of prothrombin into thrombin by the protease, factor Xa.	Phosphatidylserines	20-22	coagulation factor X	Homo sapiens	110-119
15967578-5	2005	AC polarography has allowed the detection for the first time of insertion of factor Xa into condensed monolayers containing phosphatidylserine (PS) and phosphatidylcholine (PC) either 100% PS or 25% PS in the presence of Ca2+.	Phosphatidylserines	124-142	coagulation factor X	Homo sapiens	77-86
15967578-5	2005	AC polarography has allowed the detection for the first time of insertion of factor Xa into condensed monolayers containing phosphatidylserine (PS) and phosphatidylcholine (PC) either 100% PS or 25% PS in the presence of Ca2+.	Phosphatidylserines	144-146	coagulation factor X	Homo sapiens	77-86
15967578-5	2005	AC polarography has allowed the detection for the first time of insertion of factor Xa into condensed monolayers containing phosphatidylserine (PS) and phosphatidylcholine (PC) either 100% PS or 25% PS in the presence of Ca2+.	Phosphatidylserines	189-191	coagulation factor X	Homo sapiens	77-86
15967578-5	2005	AC polarography has allowed the detection for the first time of insertion of factor Xa into condensed monolayers containing phosphatidylserine (PS) and phosphatidylcholine (PC) either 100% PS or 25% PS in the presence of Ca2+.	Phosphatidylserines	189-191	coagulation factor X	Homo sapiens	77-86
16042397-11	2005	Finally, we show the catalytic activity of DGKA was significantly enhanced by phosphatidylserine (PS) and phosphatidic acid (PA).	Phosphatidylserines	78-96	diacylglycerol kinase alpha	Homo sapiens	43-47
16042397-11	2005	Finally, we show the catalytic activity of DGKA was significantly enhanced by phosphatidylserine (PS) and phosphatidic acid (PA).	Phosphatidylserines	98-100	diacylglycerol kinase alpha	Homo sapiens	43-47
16040805-3	2005	Docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid highly enriched in neuronal membranes, promotes neuronal survival by facilitating membrane translocation/activation of Akt through its capacity to increase phosphatidylserine (PS), the major acidic phospholipid in cell membranes.	Phosphatidylserines	218-236	AKT serine/threonine kinase 1	Homo sapiens	181-184
16040805-3	2005	Docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid highly enriched in neuronal membranes, promotes neuronal survival by facilitating membrane translocation/activation of Akt through its capacity to increase phosphatidylserine (PS), the major acidic phospholipid in cell membranes.	Phosphatidylserines	238-240	AKT serine/threonine kinase 1	Homo sapiens	181-184
16025105-4	2005	Changes in PS distribution were shown to modulate several membrane activities: Ca(2+) and Na(+) uptake through the P2X(7) cation channel itself; P2X(7)-stimulated shedding of the homing receptor CD62L; and reversal of activity of the multidrug transporter P-glycoprotein.	Phosphatidylserines	11-13	purinergic receptor P2X 7	Homo sapiens	115-121
16025105-4	2005	Changes in PS distribution were shown to modulate several membrane activities: Ca(2+) and Na(+) uptake through the P2X(7) cation channel itself; P2X(7)-stimulated shedding of the homing receptor CD62L; and reversal of activity of the multidrug transporter P-glycoprotein.	Phosphatidylserines	11-13	purinergic receptor P2X 7	Homo sapiens	145-151
16025105-4	2005	Changes in PS distribution were shown to modulate several membrane activities: Ca(2+) and Na(+) uptake through the P2X(7) cation channel itself; P2X(7)-stimulated shedding of the homing receptor CD62L; and reversal of activity of the multidrug transporter P-glycoprotein.	Phosphatidylserines	11-13	selectin L	Homo sapiens	195-200
15729717-6	2005	This was accompanied by apoptosis, as revealed by staining cells for exposure of phosphatidylserine at their surface (binding of Annexin V) and FACS analysis of propidium iodide labeled cells.	Phosphatidylserines	81-99	annexin A5	Homo sapiens	129-138
15905177-4	2005	By using C6-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) (NBD)-labeled phospholipid analogues, we observed elevated redistribution of phosphatidylserine and phosphatidylethanolamine but not of phosphatidylcholine analogues from the cytoplasmic to the exoplasmic leaflet of the plasma membrane of ABCA1-GFP expressing cells.	Phosphatidylserines	127-145	ATP binding cassette subfamily A member 1	Canis lupus familiaris	289-294
16113793-2	2005	Fibrillar type-I collagens, including collagen from human heart, were most potent in enhancing thrombin generation, in a way dependent on exposure of phosphatidylserine (PS) at the platelet surface.	Phosphatidylserines	150-168	coagulation factor II, thrombin	Homo sapiens	95-103
16113793-2	2005	Fibrillar type-I collagens, including collagen from human heart, were most potent in enhancing thrombin generation, in a way dependent on exposure of phosphatidylserine (PS) at the platelet surface.	Phosphatidylserines	170-172	coagulation factor II, thrombin	Homo sapiens	95-103
15890312-9	2005	We performed a membrane-binding assay for annexin V, a calcium-dependent protein that binds to phosphatidylserine (PS).	Phosphatidylserines	95-113	annexin A5	Homo sapiens	42-51
15890312-10	2005	The binding of annexin V depended on the concentration of PS and decreased as ionic strength increased to physiological levels.	Phosphatidylserines	58-60	annexin A5	Homo sapiens	15-24
15693752-2	2005	Phorbol esters, calcium or immunoglobulin receptors stimulate SK1 by promoting its translocation to the plasma membrane, which brings it into proximity both to its substrate (i.e. sphingosine) and to activating acidic phospholipids (e.g. phosphatidylserine).	Phosphatidylserines	238-256	sphingosine kinase 1	Homo sapiens	62-65
15896453-5	2005	In the presence of phosphatidylserine (PS), all of 12 compounds 1-12 activated PKC (mainly alpha, beta, and gamma isozymes) but only three compounds 1-3 activated PKC even in the absence of PS.	Phosphatidylserines	19-37	proline rich transmembrane protein 2	Homo sapiens	79-82
15896453-5	2005	In the presence of phosphatidylserine (PS), all of 12 compounds 1-12 activated PKC (mainly alpha, beta, and gamma isozymes) but only three compounds 1-3 activated PKC even in the absence of PS.	Phosphatidylserines	39-41	proline rich transmembrane protein 2	Homo sapiens	79-82
16126965-11	2005	In contrast, the antibodies HVA2 and HLC9 (which also showed somatic hypermutations in the CDR3 region) presented polyreactivity to several phospholipids-cardiolipin, phosphatidyl-serine, -ethanolamine, -inositol, -choline, and sphingomyelin-but not to beta2-GPI.	Phosphatidylserines	167-186	CDR3	Homo sapiens	91-95
16243300-5	2005	Investigation of the mechanisms involved in CCL2 induction showed that treatment of splenic T cells with the tumor-derived factors GM-CSF and phosphatidyl serine (PS) resulted in increased CCL2 production.	Phosphatidylserines	142-161	chemokine (C-C motif) ligand 2	Mus musculus	44-48
16243300-5	2005	Investigation of the mechanisms involved in CCL2 induction showed that treatment of splenic T cells with the tumor-derived factors GM-CSF and phosphatidyl serine (PS) resulted in increased CCL2 production.	Phosphatidylserines	142-161	chemokine (C-C motif) ligand 2	Mus musculus	189-193
16243300-5	2005	Investigation of the mechanisms involved in CCL2 induction showed that treatment of splenic T cells with the tumor-derived factors GM-CSF and phosphatidyl serine (PS) resulted in increased CCL2 production.	Phosphatidylserines	163-165	chemokine (C-C motif) ligand 2	Mus musculus	44-48
16243300-5	2005	Investigation of the mechanisms involved in CCL2 induction showed that treatment of splenic T cells with the tumor-derived factors GM-CSF and phosphatidyl serine (PS) resulted in increased CCL2 production.	Phosphatidylserines	163-165	chemokine (C-C motif) ligand 2	Mus musculus	189-193
15878509-3	2005	We investigated the use of (124)I-annexin V, which binds to phosphatidylserine (PS) on the surface of apoptotic cells, as a potential positron emission tomography (PET) radioligand for the noninvasive measurement of apoptosis in vivo.	Phosphatidylserines	60-78	annexin A5	Homo sapiens	34-43
15878509-3	2005	We investigated the use of (124)I-annexin V, which binds to phosphatidylserine (PS) on the surface of apoptotic cells, as a potential positron emission tomography (PET) radioligand for the noninvasive measurement of apoptosis in vivo.	Phosphatidylserines	80-82	annexin A5	Homo sapiens	34-43
15878510-3	2005	[(124)I]4IB-annexin V binds to phosphatidylserine-coated microtiter plates and apoptotic Jurkat cells and accumulates in hepatic apoptotic lesions in mice treated with anti-Fas antibody, while [(124)I]4IB-ovalbumin does not.	Phosphatidylserines	31-49	annexin A5	Homo sapiens	12-21
15878510-4	2005	In comparison with (124)I-annexin V, [(124)I]4IB-annexin V has a higher rate of binding to phosphatidylserine in vitro, a higher kidney and urine uptake, a lower thyroid and stomach content uptake, greater plasma stability and a lower rate of plasma clearance.	Phosphatidylserines	91-109	annexin A5	Homo sapiens	49-58
15809489-2	2005	Because one of the earliest measurable events in apoptosis is the eversion of phosphatidylserine from the inner membrane leaflet to the outer cell surface, annexin V has proven useful for detecting the earliest stages of apoptosis.	Phosphatidylserines	78-96	annexin A5	Rattus norvegicus	156-165
15820759-3	2005	We developed a phosphatidylserine-ELISA capable of distinguishing wild type from point mutant annexin V that is known to have a lower phosphatidylserine binding affinity.	Phosphatidylserines	15-33	annexin A5	Homo sapiens	94-103
15615726-8	2005	To test this, we treated rats with VP015 (phospholipid microparticles-incorporating phosphatidylserine), which increases IL-4 concentration in hippocampus.	Phosphatidylserines	84-102	interleukin 4	Rattus norvegicus	121-125
15736953-5	2005	The ability of Raf-1 and B-Raf to bind phosphatidylserine (PS) and phosphatidic acid (PA) has been show to facilitate Raf membrane associations and regulate Raf kinase activity.	Phosphatidylserines	39-57	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	15-20
15736953-5	2005	The ability of Raf-1 and B-Raf to bind phosphatidylserine (PS) and phosphatidic acid (PA) has been show to facilitate Raf membrane associations and regulate Raf kinase activity.	Phosphatidylserines	39-57	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	25-30
15736953-5	2005	The ability of Raf-1 and B-Raf to bind phosphatidylserine (PS) and phosphatidic acid (PA) has been show to facilitate Raf membrane associations and regulate Raf kinase activity.	Phosphatidylserines	39-57	zinc fingers and homeoboxes 2	Homo sapiens	15-18
15736953-5	2005	The ability of Raf-1 and B-Raf to bind phosphatidylserine (PS) and phosphatidic acid (PA) has been show to facilitate Raf membrane associations and regulate Raf kinase activity.	Phosphatidylserines	39-57	zinc fingers and homeoboxes 2	Homo sapiens	27-30
15736953-5	2005	The ability of Raf-1 and B-Raf to bind phosphatidylserine (PS) and phosphatidic acid (PA) has been show to facilitate Raf membrane associations and regulate Raf kinase activity.	Phosphatidylserines	59-61	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	15-20
15736953-5	2005	The ability of Raf-1 and B-Raf to bind phosphatidylserine (PS) and phosphatidic acid (PA) has been show to facilitate Raf membrane associations and regulate Raf kinase activity.	Phosphatidylserines	59-61	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	25-30
15736953-5	2005	The ability of Raf-1 and B-Raf to bind phosphatidylserine (PS) and phosphatidic acid (PA) has been show to facilitate Raf membrane associations and regulate Raf kinase activity.	Phosphatidylserines	59-61	zinc fingers and homeoboxes 2	Homo sapiens	15-18
15736953-5	2005	The ability of Raf-1 and B-Raf to bind phosphatidylserine (PS) and phosphatidic acid (PA) has been show to facilitate Raf membrane associations and regulate Raf kinase activity.	Phosphatidylserines	59-61	zinc fingers and homeoboxes 2	Homo sapiens	27-30
15527422-2	2005	This suggestion is based mainly on the presumption that beta2GPI has an appreciable interaction with PS (phosphatidylserine)-exposing cell membranes.	Phosphatidylserines	101-103	apolipoprotein H	Homo sapiens	56-64
15527422-2	2005	This suggestion is based mainly on the presumption that beta2GPI has an appreciable interaction with PS (phosphatidylserine)-exposing cell membranes.	Phosphatidylserines	105-124	apolipoprotein H	Homo sapiens	56-64
15723529-4	2005	We show here that endostatin binds to membranes containing acidic phospholipids, phosphatidylserine (PS) or phosphatidylglycerol (PG).	Phosphatidylserines	81-99	collagen type XVIII alpha 1 chain	Homo sapiens	18-28
15723529-4	2005	We show here that endostatin binds to membranes containing acidic phospholipids, phosphatidylserine (PS) or phosphatidylglycerol (PG).	Phosphatidylserines	101-103	collagen type XVIII alpha 1 chain	Homo sapiens	18-28
15723529-7	2005	Quenching by endostatin of the fluorescence of a pyrene-labeled phospholipid analogue in PS containing membranes was seen, while there was no effect for PC liposomes.	Phosphatidylserines	89-91	collagen type XVIII alpha 1 chain	Homo sapiens	13-23
15723529-8	2005	Resonance energy transfer from the Trp residues of endostatin to a dansyl-labeled phospholipid further confirmed the association of endostatin with PS-containing membranes, whereas there was no binding to PC liposomes.	Phosphatidylserines	148-150	collagen type XVIII alpha 1 chain	Homo sapiens	51-61
15723529-8	2005	Resonance energy transfer from the Trp residues of endostatin to a dansyl-labeled phospholipid further confirmed the association of endostatin with PS-containing membranes, whereas there was no binding to PC liposomes.	Phosphatidylserines	148-150	collagen type XVIII alpha 1 chain	Homo sapiens	132-142
15723529-9	2005	Intriguingly, the association of endostatin with PS-containing liposomes triggered the formation of fibers, with Congo red staining producing green birefringence characteristic for amyloid.	Phosphatidylserines	49-51	collagen type XVIII alpha 1 chain	Homo sapiens	33-43
15723529-12	2005	Because PS has been reported to be exposed in the outer surface of the plasma membrane of cancer cells and vascular endothelial cells, our results suggest that this lipid could represent a target for endostatin in the cancer cell surface and tumors, thus suggesting a novel mechanism of its action.	Phosphatidylserines	8-10	collagen type XVIII alpha 1 chain	Homo sapiens	200-210
15673687-9	2005	Moreover, our data link another PS-dependent signal to the CrkII/Dock180/Rac1 module.	Phosphatidylserines	32-34	CRK proto-oncogene, adaptor protein	Homo sapiens	59-64
15673687-9	2005	Moreover, our data link another PS-dependent signal to the CrkII/Dock180/Rac1 module.	Phosphatidylserines	32-34	dedicator of cytokinesis 1	Homo sapiens	65-72
15673687-9	2005	Moreover, our data link another PS-dependent signal to the CrkII/Dock180/Rac1 module.	Phosphatidylserines	32-34	Rac family small GTPase 1	Homo sapiens	73-77
15661897-1	2005	Phosphatidylserine (PS) on apoptotic cells promotes their uptake and induces anti-inflammatory responses in phagocytes, including TGF-beta release.	Phosphatidylserines	0-18	transforming growth factor, beta 1	Mus musculus	130-138
15661897-1	2005	Phosphatidylserine (PS) on apoptotic cells promotes their uptake and induces anti-inflammatory responses in phagocytes, including TGF-beta release.	Phosphatidylserines	20-22	transforming growth factor, beta 1	Mus musculus	130-138
15661897-7	2005	TGF-beta appears to play a critical role in this inhibition, as the inhibitory effects of PS were reversed by in vivo administration of anti-TGF-beta Ab.	Phosphatidylserines	90-92	transforming growth factor, beta 1	Mus musculus	0-8
15661897-7	2005	TGF-beta appears to play a critical role in this inhibition, as the inhibitory effects of PS were reversed by in vivo administration of anti-TGF-beta Ab.	Phosphatidylserines	90-92	transforming growth factor, beta 1	Mus musculus	141-149
15670043-2	2005	Two pairs of solvent-exposed amino acids, Tyr(1956)/Leu(1957) in the C1 domain and Trp(2063)/Trp(2064) in the C2 domain, each make significant contributions to the affinity of FVa for PS membranes, but individually neither pair of amino acids is required for prothrombinase assembly on 25% PS membranes.	Phosphatidylserines	184-186	coagulation factor X	Homo sapiens	259-273
15628842-1	2005	Site-directed spin labeling is used to determine the orientation and depth of insertion of the second C2 domain from synaptotagmin I (C2B) into membrane vesicles composed of phosphatidylcholine (PC) and phosphatidylserine (PS).	Phosphatidylserines	203-221	synaptotagmin 1	Homo sapiens	117-132
15628842-1	2005	Site-directed spin labeling is used to determine the orientation and depth of insertion of the second C2 domain from synaptotagmin I (C2B) into membrane vesicles composed of phosphatidylcholine (PC) and phosphatidylserine (PS).	Phosphatidylserines	203-221	secretoglobin family 2B member 3, pseudogene	Homo sapiens	134-137
15628842-9	2005	EPR spectroscopy indicates that the C2B domain has different interactions with PC/PS membranes containing 1 mol % phosphatidylinositol 4,5-bisphosphate.	Phosphatidylserines	82-84	secretoglobin family 2B member 3, pseudogene	Homo sapiens	36-39
15591816-4	2005	RESULTS: When ovalbumin-liposome conjugates were added to a culture of macrophages, enhanced recognition and processing of ovalbumin by the macrophages were observed by the inclusion of PS in the liposomes.	Phosphatidylserines	186-188	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	14-23
15591816-4	2005	RESULTS: When ovalbumin-liposome conjugates were added to a culture of macrophages, enhanced recognition and processing of ovalbumin by the macrophages were observed by the inclusion of PS in the liposomes.	Phosphatidylserines	186-188	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	123-132
15541376-5	2004	Uptake of N-Rh-PE from liposomes containing phosphatidylserine was higher than [(3)H]COE, and was further enhanced by apolipoprotein A-I, confirming involvement of SR-BI in the selective uptake of liposomal N-Rh-PE by cells.	Phosphatidylserines	44-62	scavenger receptor class B member 1	Cricetulus griseus	164-169
15377529-5	2004	The decrease in OSIR at the onset of apoptosis preceded phosphatidyl serine exposure by 5 h. In the YFP-BCL-xL cell variant, the initial OSIR was already approximately 24% lower than the initial OSIR in YFP and nontransfected cells, and only decreased by &lt;10% after STS treatment.	Phosphatidylserines	56-75	BCL2 like 1	Homo sapiens	104-110
15375386-6	2004	Most importantly, blockade of phagocytosis in vivo, either with gadolinium chloride to disrupt phagocyte function or with annexin V to block binding of exposed phosphotidylserine to its receptor on phagocytes, abolished the beneficial effect of transfused apoptotic cells on heart allograft survival.	Phosphatidylserines	160-178	annexin A5	Homo sapiens	122-131
15537503-9	2004	Interestingly, immediately after H(2)O(2) induction, the number of annexin A5-positive cells was higher than that of PS-positive cells (p&lt;/=0.05) and colabeling showed that half annexin A5-positive cells were PS-negative.	Phosphatidylserines	212-214	annexin A5	Rattus norvegicus	181-191
15504369-1	2004	We have already reported that TGF-beta could be involved in the inhibitory effects of negatively charged liposomes composed of phosphatidylserine (PS-liposome) on the production of nitric oxide (NO) by mouse peritoneal macrophages stimulated with LPS [Biochem.	Phosphatidylserines	127-145	transforming growth factor, beta 1	Mus musculus	30-38
15545357-3	2004	Based on the recent identification of human cell membrane phosphatidylserine (PS) in the outer coat of HIV-1, we define a novel role for annexin II, a PS-binding moiety, as a cellular cofactor supporting macrophage HIV-1 infection.	Phosphatidylserines	78-80	annexin A2	Homo sapiens	137-147
15481031-2	2004	We have used atomic force microscopy (AFM) to study the interaction of synapsin I with negatively charged lipid domains in phase-separated supported lipid bilayers prepared from mixtures of phosphatidylcholines (PCs) and phosphatidylserines (PSs).	Phosphatidylserines	221-240	synapsin I	Homo sapiens	71-81
15481031-2	2004	We have used atomic force microscopy (AFM) to study the interaction of synapsin I with negatively charged lipid domains in phase-separated supported lipid bilayers prepared from mixtures of phosphatidylcholines (PCs) and phosphatidylserines (PSs).	Phosphatidylserines	242-245	synapsin I	Homo sapiens	71-81
15522909-4	2004	In this study, we showed that Hsp70 and Hsc70 display a highly selective interaction with phosphatidylserine moieties on membranes, followed by rapid incorporation into the lipid bilayer.	Phosphatidylserines	90-108	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	30-35
15522909-4	2004	In this study, we showed that Hsp70 and Hsc70 display a highly selective interaction with phosphatidylserine moieties on membranes, followed by rapid incorporation into the lipid bilayer.	Phosphatidylserines	90-108	heat shock protein family A (Hsp70) member 8	Rattus norvegicus	40-45
15456534-9	2004	The proliferation and collagen synthesis were enhanced by PKC activator (containing phosphatidylserine, diacylglycerol and Ca2+) and PKA inhibitor [H(7)250 micromol/L, 1-(5-isoquinolinylsulfonyl)-2-methyl piperazine], and inhibited by PKC inhibitor (GF109 250 micromol/L) and PKA activator (cAMP 25 micromol/L) (P&lt;0.01).	Phosphatidylserines	84-102	proline rich transmembrane protein 2	Homo sapiens	58-61
15379970-7	2004	Intensive expression of PS on the sperm plasma membrane surface (assayed by annexin V positive staining) was detected in the smokers group.	Phosphatidylserines	24-26	annexin A5	Homo sapiens	76-85
15322157-6	2004	DCs exposed to PS had diminished capacity to stimulate allogeneic T cell proliferation and to activate IFN-gamma-producing CD4(+) T cells.	Phosphatidylserines	15-17	interferon gamma	Homo sapiens	103-112
15322157-6	2004	DCs exposed to PS had diminished capacity to stimulate allogeneic T cell proliferation and to activate IFN-gamma-producing CD4(+) T cells.	Phosphatidylserines	15-17	CD4 molecule	Homo sapiens	123-126
15333038-6	2004	In this study, we demonstrate that ISI values of thromboplastin reagents based on relipidated, recombinant human tissue factor can be controlled by a combination of changes in the phospholipid content (in particular, the levels of phosphatidylserine and phosphatidylethanolamine) and ionic strength.	Phosphatidylserines	231-249	coagulation factor III, tissue factor	Homo sapiens	113-126
15301528-4	2004	In this study, we show that membranes containing phosphatidylserine (PS), a negatively charged phospholipid, induce a rapid formation of fibers by a variety of proteins, viz., lysozyme, insulin, glyceraldehyde-3-phosphate dehydrogenase, myoglobin, transthyretin, cytochrome c, histone H1, and alpha-lactalbumin.	Phosphatidylserines	49-67	insulin	Homo sapiens	186-193
15301528-4	2004	In this study, we show that membranes containing phosphatidylserine (PS), a negatively charged phospholipid, induce a rapid formation of fibers by a variety of proteins, viz., lysozyme, insulin, glyceraldehyde-3-phosphate dehydrogenase, myoglobin, transthyretin, cytochrome c, histone H1, and alpha-lactalbumin.	Phosphatidylserines	49-67	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	195-235
15301528-4	2004	In this study, we show that membranes containing phosphatidylserine (PS), a negatively charged phospholipid, induce a rapid formation of fibers by a variety of proteins, viz., lysozyme, insulin, glyceraldehyde-3-phosphate dehydrogenase, myoglobin, transthyretin, cytochrome c, histone H1, and alpha-lactalbumin.	Phosphatidylserines	49-67	myoglobin	Homo sapiens	237-246
15301528-4	2004	In this study, we show that membranes containing phosphatidylserine (PS), a negatively charged phospholipid, induce a rapid formation of fibers by a variety of proteins, viz., lysozyme, insulin, glyceraldehyde-3-phosphate dehydrogenase, myoglobin, transthyretin, cytochrome c, histone H1, and alpha-lactalbumin.	Phosphatidylserines	49-67	cytochrome c, somatic	Homo sapiens	263-275
15301528-4	2004	In this study, we show that membranes containing phosphatidylserine (PS), a negatively charged phospholipid, induce a rapid formation of fibers by a variety of proteins, viz., lysozyme, insulin, glyceraldehyde-3-phosphate dehydrogenase, myoglobin, transthyretin, cytochrome c, histone H1, and alpha-lactalbumin.	Phosphatidylserines	49-67	H1.0 linker histone	Homo sapiens	277-287
15301528-4	2004	In this study, we show that membranes containing phosphatidylserine (PS), a negatively charged phospholipid, induce a rapid formation of fibers by a variety of proteins, viz., lysozyme, insulin, glyceraldehyde-3-phosphate dehydrogenase, myoglobin, transthyretin, cytochrome c, histone H1, and alpha-lactalbumin.	Phosphatidylserines	49-67	lactalbumin alpha	Homo sapiens	293-310
15301528-4	2004	In this study, we show that membranes containing phosphatidylserine (PS), a negatively charged phospholipid, induce a rapid formation of fibers by a variety of proteins, viz., lysozyme, insulin, glyceraldehyde-3-phosphate dehydrogenase, myoglobin, transthyretin, cytochrome c, histone H1, and alpha-lactalbumin.	Phosphatidylserines	69-71	insulin	Homo sapiens	186-193
15301528-4	2004	In this study, we show that membranes containing phosphatidylserine (PS), a negatively charged phospholipid, induce a rapid formation of fibers by a variety of proteins, viz., lysozyme, insulin, glyceraldehyde-3-phosphate dehydrogenase, myoglobin, transthyretin, cytochrome c, histone H1, and alpha-lactalbumin.	Phosphatidylserines	69-71	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	195-235
15301528-4	2004	In this study, we show that membranes containing phosphatidylserine (PS), a negatively charged phospholipid, induce a rapid formation of fibers by a variety of proteins, viz., lysozyme, insulin, glyceraldehyde-3-phosphate dehydrogenase, myoglobin, transthyretin, cytochrome c, histone H1, and alpha-lactalbumin.	Phosphatidylserines	69-71	myoglobin	Homo sapiens	237-246
15301528-4	2004	In this study, we show that membranes containing phosphatidylserine (PS), a negatively charged phospholipid, induce a rapid formation of fibers by a variety of proteins, viz., lysozyme, insulin, glyceraldehyde-3-phosphate dehydrogenase, myoglobin, transthyretin, cytochrome c, histone H1, and alpha-lactalbumin.	Phosphatidylserines	69-71	cytochrome c, somatic	Homo sapiens	263-275
15301528-4	2004	In this study, we show that membranes containing phosphatidylserine (PS), a negatively charged phospholipid, induce a rapid formation of fibers by a variety of proteins, viz., lysozyme, insulin, glyceraldehyde-3-phosphate dehydrogenase, myoglobin, transthyretin, cytochrome c, histone H1, and alpha-lactalbumin.	Phosphatidylserines	69-71	H1.0 linker histone	Homo sapiens	277-287
15301528-4	2004	In this study, we show that membranes containing phosphatidylserine (PS), a negatively charged phospholipid, induce a rapid formation of fibers by a variety of proteins, viz., lysozyme, insulin, glyceraldehyde-3-phosphate dehydrogenase, myoglobin, transthyretin, cytochrome c, histone H1, and alpha-lactalbumin.	Phosphatidylserines	69-71	lactalbumin alpha	Homo sapiens	293-310
15298909-2	2004	We used a well-characterized peptide corresponding to the basic effector domain of myristoylated alanine-rich C kinase substrate, MARCKS(151-175), that was fluorescently labeled with Alexa488, and measured its binding to large unilamellar vesicles (diameter approximately 100 nm) composed of phosphatidylcholine and phosphatidylserine or phosphatidylinositol 4,5-bisphosphate.	Phosphatidylserines	316-334	myristoylated alanine rich protein kinase C substrate	Homo sapiens	130-136
15377859-9	2004	Additionally, phosphatidylserine is exposed and at a later time point cytochrome c is released and caspase-3 is activated.	Phosphatidylserines	14-32	caspase 3	Homo sapiens	99-108
15304031-6	2004	PS exposure in agonist-stimulated platelets was markedly reduced by inhibition of caspase-3 activity but was not affected by inhibition of calpain activity.	Phosphatidylserines	0-2	caspase 3	Homo sapiens	82-91
15246365-5	2004	Annexin V is a 36kD protein that binds to exposed phosphatidylserine (PS) on dying cells.	Phosphatidylserines	50-68	annexin A5	Homo sapiens	0-9
15246365-5	2004	Annexin V is a 36kD protein that binds to exposed phosphatidylserine (PS) on dying cells.	Phosphatidylserines	70-72	annexin A5	Homo sapiens	0-9
15249668-3	2004	Drs2p from budding yeast localizes to the trans-Golgi network (TGN), and here we show that this membrane contains an ATP-dependent APLT that flips 7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) PS and PE derivatives from the luminal to the cytosolic leaflet.	Phosphatidylserines	186-188	aminophospholipid-translocating P4-type ATPase DRS2	Saccharomyces cerevisiae S288C	0-5
15249668-7	2004	However, cho1 yeast strains that are unable to synthesize PS do not phenocopy drs2 but instead transport proteins normally via the secretory pathway.	Phosphatidylserines	58-60	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	9-13
15155790-10	2004	Together, these data indicate that, under physiological conditions of flow, both adhesive receptors GPIb and alphaIIbbeta3 facilitate GPVI-mediated PS exposure by stabilizing platelet binding to collagen.	Phosphatidylserines	148-150	glycoprotein 6 (platelet)	Mus musculus	134-138
15240711-10	2004	Annexin V assays showed that ATP stimulation resulted in a rapid phosphatidylserine (PS) exposure on the cell surface of RAW264.7 macrophages, and that PS-exposed microvesicles contained icIL-1ra1.	Phosphatidylserines	152-154	annexin A5	Mus musculus	0-9
15240711-10	2004	Annexin V assays showed that ATP stimulation resulted in a rapid phosphatidylserine (PS) exposure on the cell surface of RAW264.7 macrophages, and that PS-exposed microvesicles contained icIL-1ra1.	Phosphatidylserines	152-154	interleukin 1 receptor antagonist	Mus musculus	187-196
15213851-6	2004	We report that phosphatidylserine exposure, induced by the lipophilic local anaesthetics dibucaine and tetracaine, was accompanied by depolarization of the mitochondrial membrane, cytochrome c release, calpain-processing of caspases 9 and 3 to active enzymes, as well as a prolonged increase in both cytosolic and mitochondrial Ca(2+) concentrations.	Phosphatidylserines	15-33	cytochrome c, somatic	Homo sapiens	180-192
15201330-6	2004	Quantitative measures of Abeta-evoked apoptotic cell death, using Hoechst and phosphotidylserine staining, confirm neuroprotective effects of AC187.	Phosphatidylserines	78-96	amyloid beta precursor protein	Rattus norvegicus	25-30
15149850-2	2004	Employing a constitutively active form of Akt1 (myristoylated Akt1) in endothelial cells (ECs), we demonstrate that Akt1 not only modulates intrinsic pathways of EC injury that involve genomic DNA destruction, but also uniquely regulates extrinsic mechanisms of cellular inflammation mediated by phosphatidylserine exposure (PS) and microglial activation.	Phosphatidylserines	296-314	AKT serine/threonine kinase 1	Homo sapiens	42-46
15149850-2	2004	Employing a constitutively active form of Akt1 (myristoylated Akt1) in endothelial cells (ECs), we demonstrate that Akt1 not only modulates intrinsic pathways of EC injury that involve genomic DNA destruction, but also uniquely regulates extrinsic mechanisms of cellular inflammation mediated by phosphatidylserine exposure (PS) and microglial activation.	Phosphatidylserines	296-314	AKT serine/threonine kinase 1	Homo sapiens	62-66
15149850-2	2004	Employing a constitutively active form of Akt1 (myristoylated Akt1) in endothelial cells (ECs), we demonstrate that Akt1 not only modulates intrinsic pathways of EC injury that involve genomic DNA destruction, but also uniquely regulates extrinsic mechanisms of cellular inflammation mediated by phosphatidylserine exposure (PS) and microglial activation.	Phosphatidylserines	296-314	AKT serine/threonine kinase 1	Homo sapiens	62-66
15136173-2	2004	The annexin V-117 mutant was labeled with fluorescein iodoacetamide on its single N-terminal cysteine residue; binding to phospholipid vesicles containing phosphatidylserine (PS) and 2% rhodamine-phosphatidylethanolamine was measured by fluorescence quenching due to resonance energy transfer; binding to cells with exposed PS was measured by fluorometry after elution of bound protein.	Phosphatidylserines	155-173	annexin A5	Homo sapiens	4-13
15136173-2	2004	The annexin V-117 mutant was labeled with fluorescein iodoacetamide on its single N-terminal cysteine residue; binding to phospholipid vesicles containing phosphatidylserine (PS) and 2% rhodamine-phosphatidylethanolamine was measured by fluorescence quenching due to resonance energy transfer; binding to cells with exposed PS was measured by fluorometry after elution of bound protein.	Phosphatidylserines	175-177	annexin A5	Homo sapiens	4-13
15145599-4	2004	This suggests that administration of PS liposomes protects against the deleterious effects of LPS possibly through generation of the anti-inflammatory cytokine IL-10.	Phosphatidylserines	37-39	interleukin 10	Rattus norvegicus	160-165
15154017-4	2004	After cell individualization by dithiothreitol and ethylenediamine tetraacetic acid, two-thirds of human IEC can be stained with Annexin-V due to their surface exposure of phosphatidyl serine, a sign of apoptosis.	Phosphatidylserines	172-191	annexin A5	Homo sapiens	129-138
14764526-6	2004	The circulating neutrophils and eosinophils (but not monocytes or lymphocytes) showed annexin-V binding, suggesting phosphatidylserine (PS) exposure due to apoptosis.	Phosphatidylserines	116-134	annexin A5	Homo sapiens	86-95
15144226-7	2004	A relatively minor phospholipid species, phosphatidylserine (PS), was markedly oxidized 3 h after Mel treatment in HL-60 cells (but not in HP100 cells) where it was significantly inhibited by exogenously added CAT.	Phosphatidylserines	41-59	catalase	Homo sapiens	210-213
15144226-7	2004	A relatively minor phospholipid species, phosphatidylserine (PS), was markedly oxidized 3 h after Mel treatment in HL-60 cells (but not in HP100 cells) where it was significantly inhibited by exogenously added CAT.	Phosphatidylserines	61-63	catalase	Homo sapiens	210-213
15473137-1	2004	In vitro phosphorylation of 180-kDa protein, obtained by immunoprecipitation of adipocyte homogenate with anti-IRS-1 antibody was increased with the addition of conventional PKC in the presence of Ca2+, phosphatidylserine (PS) and diolein (DL).	Phosphatidylserines	203-221	insulin receptor substrate 1	Canis lupus familiaris	111-116
15473137-1	2004	In vitro phosphorylation of 180-kDa protein, obtained by immunoprecipitation of adipocyte homogenate with anti-IRS-1 antibody was increased with the addition of conventional PKC in the presence of Ca2+, phosphatidylserine (PS) and diolein (DL).	Phosphatidylserines	203-221	protein kinase C beta	Canis lupus familiaris	174-177
15473137-1	2004	In vitro phosphorylation of 180-kDa protein, obtained by immunoprecipitation of adipocyte homogenate with anti-IRS-1 antibody was increased with the addition of conventional PKC in the presence of Ca2+, phosphatidylserine (PS) and diolein (DL).	Phosphatidylserines	223-225	insulin receptor substrate 1	Canis lupus familiaris	111-116
15473137-1	2004	In vitro phosphorylation of 180-kDa protein, obtained by immunoprecipitation of adipocyte homogenate with anti-IRS-1 antibody was increased with the addition of conventional PKC in the presence of Ca2+, phosphatidylserine (PS) and diolein (DL).	Phosphatidylserines	223-225	protein kinase C beta	Canis lupus familiaris	174-177
15173196-5	2004	Affinity analysis by means of surface plasmon resonance showed that the K(D) of the interaction between annexin V and sulfatide is 1.2 micro M. Kinetic turbidometric assaying of plasma coagulation initiated by CaCl(2) revealed that the coagulation rate in the presence of sulfatide or phosphatidylserine was decreased by annexin V.	Phosphatidylserines	285-303	annexin A5	Homo sapiens	104-113
15173196-6	2004	These results suggest that annexin V regulates coagulability in the blood stream by binding not only to phosphatidylserine but also to sulfatide.	Phosphatidylserines	104-122	annexin A5	Homo sapiens	27-36
15081634-7	2004	Staurosporine induced PS efflux was not affected by vanadate (69.6 [5.5] Lum x10(3)), but was inhibited 87.8 per cent by Z-VAD-fmk; from 71.5 [6.2] to 8.7 [3.6] Lum (x10(3)) (P&lt;0.001).	Phosphatidylserines	22-24	lumican	Homo sapiens	73-76
15081634-7	2004	Staurosporine induced PS efflux was not affected by vanadate (69.6 [5.5] Lum x10(3)), but was inhibited 87.8 per cent by Z-VAD-fmk; from 71.5 [6.2] to 8.7 [3.6] Lum (x10(3)) (P&lt;0.001).	Phosphatidylserines	22-24	lumican	Homo sapiens	161-164
15065883-9	2004	It remains to be determined whether occupancy of this PS binding site in factor Va is also required for high-affinity binding to factor Xa.	Phosphatidylserines	54-56	coagulation factor X	Homo sapiens	129-138
14752108-0	2004	Phosphatidic acid and phosphatidylserine have distinct structural and functional interactions with the nicotinic acetylcholine receptor.	Phosphatidylserines	22-40	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	103-135
14752108-8	2004	The results show that the nAChR has complex and unique interactions with both PA and PS.	Phosphatidylserines	85-87	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	26-31
14752108-9	2004	The interactions between the nAChR and PS may be bridged by divalent cations, such as calcium.	Phosphatidylserines	39-41	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	29-34
15049706-5	2004	Sedimentation assays using mixed phosphatidylserine/phosphatidylcholine (PS/PC) vesicles confirmed that the C2C domains of tricalbin 1 and 3 bind membranes in a calcium-responsive manner and showed that they are more sensitive to calcium than the C2A domain of synaptotagmin I.	Phosphatidylserines	33-51	tricalbin	Saccharomyces cerevisiae S288C	123-132
15049708-4	2004	This treatment resulted in about 10% annexin V positive cells, indicating exposure of phosphatidylserine (PS).	Phosphatidylserines	86-104	annexin A5	Homo sapiens	37-46
15049708-4	2004	This treatment resulted in about 10% annexin V positive cells, indicating exposure of phosphatidylserine (PS).	Phosphatidylserines	106-108	annexin A5	Homo sapiens	37-46
15033520-6	2004	Annexin A5 binds to these beads with high affinity if phosphatidyl serine is present within the phospholipid coat.	Phosphatidylserines	54-73	annexin A5	Homo sapiens	0-10
15025923-9	2004	HL-60 cells "loaded" with exogenous cytochrome c by mild sonication showed selective oxidation of PS in both the absence and presence of t-BuOOH.	Phosphatidylserines	98-100	cytochrome c, somatic	Homo sapiens	36-48
15025923-10	2004	Cytochrome c/hydrogen peroxide could effectively oxidize purified PS but not phosphatidylcholine in a cell-free model system.	Phosphatidylserines	66-68	cytochrome c, somatic	Homo sapiens	0-12
15025923-11	2004	Selective plasma membrane-based PS oxidation and subsequent externalization during oxidant-induced apoptosis may be mediated through the redox activity of cytochrome c.	Phosphatidylserines	32-34	cytochrome c, somatic	Homo sapiens	155-167
15009464-7	2004	However, antiphosphatidylserine antibody even at a high concentration gave only partial inhibition of the activity observed in the APTT and FXa generation systems for the cells compared with almost total inhibition for the phospholipid standard, suggesting either that cellular phosphatidylserine (PS) is less accessible to the antibody, or that PS is not the sole negatively charged phospholipid responsible for this activity.	Phosphatidylserines	13-31	coagulation factor X	Homo sapiens	140-143
15009466-4	2004	It was abolished by annexin A5, indicating dependence on phosphatidylserine (PS) exposure at activated platelets.	Phosphatidylserines	57-75	annexin A5	Homo sapiens	20-30
15009466-4	2004	It was abolished by annexin A5, indicating dependence on phosphatidylserine (PS) exposure at activated platelets.	Phosphatidylserines	77-79	annexin A5	Homo sapiens	20-30
15055535-7	2004	Furthermore, double-staining of 7.5 DIV cultures (50 microM PQ) with PI and an antibody against annexin V (AN), an impermeable plasma protein which specifically binds to phosphatidylserine (PS), showed that the percentages of AN(+)/PI(-) cells had also increased several-fold, pointing to considerable movement of PS from the inner to the outer leaflet of the plasma membrane.	Phosphatidylserines	170-188	annexin A5	Rattus norvegicus	96-105
15055535-7	2004	Furthermore, double-staining of 7.5 DIV cultures (50 microM PQ) with PI and an antibody against annexin V (AN), an impermeable plasma protein which specifically binds to phosphatidylserine (PS), showed that the percentages of AN(+)/PI(-) cells had also increased several-fold, pointing to considerable movement of PS from the inner to the outer leaflet of the plasma membrane.	Phosphatidylserines	190-192	annexin A5	Rattus norvegicus	96-105
15063003-4	2004	The analysis of the aggregation curves demonstrated that amylin and prion peptides also showed affinity for the acidic phospholipid phosphatidylserine (PS), as it has previously been shown for the Alzheimer"s Abeta40, Abeta42 peptides.	Phosphatidylserines	132-150	islet amyloid polypeptide	Homo sapiens	57-63
14757231-1	2004	Multidrug resistance-associated protein (MRP1) may function as a floppase in human red blood cells to translocate phosphatidylserine and/or phosphatidylcholine from inner membrane leaflet to outer leaflet.	Phosphatidylserines	114-132	ATP binding cassette subfamily C member 1	Homo sapiens	0-45
14979613-2	2004	The SDS-PAGE pure CYP3A4 and human NADPH-cytochrome P450 reductase had been incorporated into a binary vesicular phospholipid system of dilauroyl-phosphatidyl-choline and phosphatidyl-serine which had proven to achieve optimal nifedipine oxidase activity (19.6 nmol nifedipine oxidized x min(-1) x nmol CYP3A4(-1)).	Phosphatidylserines	171-190	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	18-24
14979613-2	2004	The SDS-PAGE pure CYP3A4 and human NADPH-cytochrome P450 reductase had been incorporated into a binary vesicular phospholipid system of dilauroyl-phosphatidyl-choline and phosphatidyl-serine which had proven to achieve optimal nifedipine oxidase activity (19.6 nmol nifedipine oxidized x min(-1) x nmol CYP3A4(-1)).	Phosphatidylserines	171-190	cytochrome p450 oxidoreductase	Homo sapiens	35-66
14654957-6	2004	During the PKC activation by phosphatidylserine, ara-CDP-DL-PBA exhibited a synergistic effect on the activation.	Phosphatidylserines	29-47	cut like homeobox 1	Homo sapiens	53-56
15306152-3	2004	However, beta(2) glycoprotein I is only antigenic for antiphospholipid antibodies when the protein is immobilised on a suitable surface such as phosphatidyl serine.	Phosphatidylserines	144-163	apolipoprotein H	Homo sapiens	9-31
14692967-7	2004	Both apheresis and pooled PLT-plasma concentrates exhibited high tissue factor-triggered thrombin generation, which was insensitive to PLT inhibition and attributable to PS-exposing microparticles.	Phosphatidylserines	170-172	coagulation factor II, thrombin	Homo sapiens	89-97
15033737-2	2003	Exposure of T cells to NAD, the substrate for ART2-catalyzed ADP-ribosylation, induces exposure of phosphatidylserine, uptake of propidium iodide, and fragmentation of DNA.	Phosphatidylserines	99-117	ADP-ribosyltransferase 1	Homo sapiens	46-50
12946267-5	2003	This suggests an enhanced exposure of PS in BCRP -overexpressing cells, which is dependent on functional BCRP.	Phosphatidylserines	38-40	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	44-48
12946267-5	2003	This suggests an enhanced exposure of PS in BCRP -overexpressing cells, which is dependent on functional BCRP.	Phosphatidylserines	38-40	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	105-109
14596606-10	2003	Alpha-synuclein exhibits a selectivity of interaction with different phospholipid spin labels when bound to phosphatidylglycerol membranes in the following order: stearic acid &gt; cardiolipin &gt; phosphatidylcholine &gt; phosphatidylglycerol approximately phosphatidylethanolamine &gt; phosphatidic acid approximately phosphatidylserine &gt; N-acyl phosphatidylethanolamine &gt; diglyceride.	Phosphatidylserines	320-338	synuclein alpha	Homo sapiens	0-15
15024957-8	2003	Annexin V binds to surface membranes that have exposed phosphatidyl serine residues resulting from programmed cell destruction.	Phosphatidylserines	55-74	annexin A5	Homo sapiens	0-9
12912985-1	2003	Phosphatidylserine (PtdSer) in mammalian cells is synthesized through the action of PtdSer synthase (PSS) 1 and 2, which catalyze the conversion of phosphatidylcholine and phosphatidylethanolamine, respectively, to PtdSer.	Phosphatidylserines	0-18	phosphatidylserine synthase 1	Homo sapiens	84-113
12853445-1	2003	We report that human galectin-1 (dGal-1), a small dimeric beta-galactoside-binding protein, induces phosphatidylserine (PS) exposure, measured by Annexin V staining, on human promyelocytic HL-60 cells, T leukemic MOLT-4 cells, and fMet-Leu-Phe-activated, but not resting, human neutrophils.	Phosphatidylserines	100-118	galectin 1	Homo sapiens	21-31
12853445-1	2003	We report that human galectin-1 (dGal-1), a small dimeric beta-galactoside-binding protein, induces phosphatidylserine (PS) exposure, measured by Annexin V staining, on human promyelocytic HL-60 cells, T leukemic MOLT-4 cells, and fMet-Leu-Phe-activated, but not resting, human neutrophils.	Phosphatidylserines	100-118	Galactose-specific C-type lectin	Drosophila melanogaster	33-39
14514016-5	2003	Employing primary hippocampal neurons from mice with a dominant negative SHP2 mutant to render the phosphatase site of the SHP2 protein biologically inactive, but functionally capable of binding substrate, neuronal injury was evaluated by trypan blue, DNA fragmentation, membrane phosphatidyl serine (PS) exposure, mitogen-activated protein (MAP) kinase phosphorylation, and cysteine protease activity.	Phosphatidylserines	280-299	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	123-127
14514016-5	2003	Employing primary hippocampal neurons from mice with a dominant negative SHP2 mutant to render the phosphatase site of the SHP2 protein biologically inactive, but functionally capable of binding substrate, neuronal injury was evaluated by trypan blue, DNA fragmentation, membrane phosphatidyl serine (PS) exposure, mitogen-activated protein (MAP) kinase phosphorylation, and cysteine protease activity.	Phosphatidylserines	301-303	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	123-127
14583346-3	2003	We hypothesized that cytochrome c (cyt c) released from mitochondria into cytosol acts as a catalyst that utilizes ROS generated by disrupted mitochondrial electron transport for PS oxidation.	Phosphatidylserines	179-181	cytochrome c, somatic	Homo sapiens	21-33
14583346-3	2003	We hypothesized that cytochrome c (cyt c) released from mitochondria into cytosol acts as a catalyst that utilizes ROS generated by disrupted mitochondrial electron transport for PS oxidation.	Phosphatidylserines	179-181	cytochrome c, somatic	Homo sapiens	35-40
14583346-9	2003	Redox catalytic involvement of cyt c in PS oxidation was further supported by our data demonstrating that: (i) specific interactions of cyt c with PS resulted in the formation of EPR-detectable protein-centered tyrosyl radicals of cyt c upon its interaction with H2O2 in the presence of PS-containing liposomes, and (ii) integration of cyt c into cytochrome c null (Cyt c -/-) cells or HL-60 cells specifically stimulates PS oxidation in the presence of H2O2 or t-BuOOH, respectively.	Phosphatidylserines	40-42	cytochrome c, somatic	Homo sapiens	31-36
14583346-9	2003	Redox catalytic involvement of cyt c in PS oxidation was further supported by our data demonstrating that: (i) specific interactions of cyt c with PS resulted in the formation of EPR-detectable protein-centered tyrosyl radicals of cyt c upon its interaction with H2O2 in the presence of PS-containing liposomes, and (ii) integration of cyt c into cytochrome c null (Cyt c -/-) cells or HL-60 cells specifically stimulates PS oxidation in the presence of H2O2 or t-BuOOH, respectively.	Phosphatidylserines	40-42	cytochrome c, somatic	Homo sapiens	136-141
14583346-9	2003	Redox catalytic involvement of cyt c in PS oxidation was further supported by our data demonstrating that: (i) specific interactions of cyt c with PS resulted in the formation of EPR-detectable protein-centered tyrosyl radicals of cyt c upon its interaction with H2O2 in the presence of PS-containing liposomes, and (ii) integration of cyt c into cytochrome c null (Cyt c -/-) cells or HL-60 cells specifically stimulates PS oxidation in the presence of H2O2 or t-BuOOH, respectively.	Phosphatidylserines	40-42	cytochrome c, somatic	Homo sapiens	136-141
14583346-9	2003	Redox catalytic involvement of cyt c in PS oxidation was further supported by our data demonstrating that: (i) specific interactions of cyt c with PS resulted in the formation of EPR-detectable protein-centered tyrosyl radicals of cyt c upon its interaction with H2O2 in the presence of PS-containing liposomes, and (ii) integration of cyt c into cytochrome c null (Cyt c -/-) cells or HL-60 cells specifically stimulates PS oxidation in the presence of H2O2 or t-BuOOH, respectively.	Phosphatidylserines	40-42	cytochrome c, somatic	Homo sapiens	136-141
14583346-9	2003	Redox catalytic involvement of cyt c in PS oxidation was further supported by our data demonstrating that: (i) specific interactions of cyt c with PS resulted in the formation of EPR-detectable protein-centered tyrosyl radicals of cyt c upon its interaction with H2O2 in the presence of PS-containing liposomes, and (ii) integration of cyt c into cytochrome c null (Cyt c -/-) cells or HL-60 cells specifically stimulates PS oxidation in the presence of H2O2 or t-BuOOH, respectively.	Phosphatidylserines	40-42	cytochrome c, somatic	Homo sapiens	347-359
14583346-9	2003	Redox catalytic involvement of cyt c in PS oxidation was further supported by our data demonstrating that: (i) specific interactions of cyt c with PS resulted in the formation of EPR-detectable protein-centered tyrosyl radicals of cyt c upon its interaction with H2O2 in the presence of PS-containing liposomes, and (ii) integration of cyt c into cytochrome c null (Cyt c -/-) cells or HL-60 cells specifically stimulates PS oxidation in the presence of H2O2 or t-BuOOH, respectively.	Phosphatidylserines	40-42	cytochrome c, somatic	Homo sapiens	366-371
14583346-9	2003	Redox catalytic involvement of cyt c in PS oxidation was further supported by our data demonstrating that: (i) specific interactions of cyt c with PS resulted in the formation of EPR-detectable protein-centered tyrosyl radicals of cyt c upon its interaction with H2O2 in the presence of PS-containing liposomes, and (ii) integration of cyt c into cytochrome c null (Cyt c -/-) cells or HL-60 cells specifically stimulates PS oxidation in the presence of H2O2 or t-BuOOH, respectively.	Phosphatidylserines	147-149	cytochrome c, somatic	Homo sapiens	31-36
14583346-9	2003	Redox catalytic involvement of cyt c in PS oxidation was further supported by our data demonstrating that: (i) specific interactions of cyt c with PS resulted in the formation of EPR-detectable protein-centered tyrosyl radicals of cyt c upon its interaction with H2O2 in the presence of PS-containing liposomes, and (ii) integration of cyt c into cytochrome c null (Cyt c -/-) cells or HL-60 cells specifically stimulates PS oxidation in the presence of H2O2 or t-BuOOH, respectively.	Phosphatidylserines	147-149	cytochrome c, somatic	Homo sapiens	136-141
14583346-9	2003	Redox catalytic involvement of cyt c in PS oxidation was further supported by our data demonstrating that: (i) specific interactions of cyt c with PS resulted in the formation of EPR-detectable protein-centered tyrosyl radicals of cyt c upon its interaction with H2O2 in the presence of PS-containing liposomes, and (ii) integration of cyt c into cytochrome c null (Cyt c -/-) cells or HL-60 cells specifically stimulates PS oxidation in the presence of H2O2 or t-BuOOH, respectively.	Phosphatidylserines	147-149	cytochrome c, somatic	Homo sapiens	136-141
14583346-9	2003	Redox catalytic involvement of cyt c in PS oxidation was further supported by our data demonstrating that: (i) specific interactions of cyt c with PS resulted in the formation of EPR-detectable protein-centered tyrosyl radicals of cyt c upon its interaction with H2O2 in the presence of PS-containing liposomes, and (ii) integration of cyt c into cytochrome c null (Cyt c -/-) cells or HL-60 cells specifically stimulates PS oxidation in the presence of H2O2 or t-BuOOH, respectively.	Phosphatidylserines	147-149	cytochrome c, somatic	Homo sapiens	136-141
14583346-9	2003	Redox catalytic involvement of cyt c in PS oxidation was further supported by our data demonstrating that: (i) specific interactions of cyt c with PS resulted in the formation of EPR-detectable protein-centered tyrosyl radicals of cyt c upon its interaction with H2O2 in the presence of PS-containing liposomes, and (ii) integration of cyt c into cytochrome c null (Cyt c -/-) cells or HL-60 cells specifically stimulates PS oxidation in the presence of H2O2 or t-BuOOH, respectively.	Phosphatidylserines	147-149	cytochrome c, somatic	Homo sapiens	347-359
14583346-9	2003	Redox catalytic involvement of cyt c in PS oxidation was further supported by our data demonstrating that: (i) specific interactions of cyt c with PS resulted in the formation of EPR-detectable protein-centered tyrosyl radicals of cyt c upon its interaction with H2O2 in the presence of PS-containing liposomes, and (ii) integration of cyt c into cytochrome c null (Cyt c -/-) cells or HL-60 cells specifically stimulates PS oxidation in the presence of H2O2 or t-BuOOH, respectively.	Phosphatidylserines	147-149	cytochrome c, somatic	Homo sapiens	366-371
14583346-10	2003	We further demonstrated that DP1 elicited externalization of PS on the surface of Jurkat cells and enhanced their recognition and phagocytosis by J774A.1 macrophages.	Phosphatidylserines	61-63	prostaglandin D2 receptor	Homo sapiens	29-32
12777465-6	2003	We demonstrate that caveolin-1 in macrophages is present in lipid rafts and colocalizes with phosphatidylserine (PS) at the cell surface of apoptotic macrophages.	Phosphatidylserines	93-111	caveolin 1, caveolae protein	Mus musculus	20-30
12777465-10	2003	Caveolin-1 may be involved in the efficient externalization of PS at the surface of the apoptotic cells.	Phosphatidylserines	63-65	caveolin 1, caveolae protein	Mus musculus	0-10
12920191-3	2003	We demonstrate that overexpression of a constitutively active form of Akt1 (myristoylated Akt1) in differentiated SH-SY5Y neuronal cells provides intrinsic cellular protection against apoptotic genomic DNA destruction and membrane phosphatidylserine (PS) exposure.	Phosphatidylserines	231-249	AKT serine/threonine kinase 1	Homo sapiens	70-74
12920191-3	2003	We demonstrate that overexpression of a constitutively active form of Akt1 (myristoylated Akt1) in differentiated SH-SY5Y neuronal cells provides intrinsic cellular protection against apoptotic genomic DNA destruction and membrane phosphatidylserine (PS) exposure.	Phosphatidylserines	231-249	AKT serine/threonine kinase 1	Homo sapiens	90-94
12855674-5	2003	UCP2 overexpression significantly suppressed markers of cell death, including TUNEL positivity, phosphatidylserine exposure, propidium iodide uptake, and caspase-3 cleavage.	Phosphatidylserines	96-114	uncoupling protein 2	Homo sapiens	0-4
12893698-1	2003	Annexin A5 (AnxA5) is a protein with high affinity for phosphatidyl serine, a phospholipid exposed on the cell surface during apoptosis.	Phosphatidylserines	55-74	annexin A5	Homo sapiens	0-10
12893698-1	2003	Annexin A5 (AnxA5) is a protein with high affinity for phosphatidyl serine, a phospholipid exposed on the cell surface during apoptosis.	Phosphatidylserines	55-74	annexin A5	Homo sapiens	12-17
12859204-6	2003	As a consequence, the ratios of LPC/PC, SPH/PC, PE/PC, and phosphatidylinositol + phosphatidylserine (PI+PS)/PC were all much higher in HDL from Abca1(-/-), compared to wild-type HDL.	Phosphatidylserines	82-100	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	145-150
12689336-9	2003	Annexin A11 binds to acidic phospholipids and to phosphatidylethanolamine in the presence of calcium; weaker calcium-independent binding to phosphatidylserine, phosphatidic acid and phosphatidylethanolamine was also observed.	Phosphatidylserines	140-158	annexin A11	Mus musculus	0-11
12730219-9	2003	In contrast to oleic acid and sphingosine that exhibited inhibitory effects, phosphatidylcholine, phosphatidylserine, and phosphatidic acid stimulated MGAT2 activities.	Phosphatidylserines	98-116	mannoside acetylglucosaminyltransferase 2	Mus musculus	151-156
12837089-2	2003	In addition, the synthetic PS scramblase increases the levels of endogenous PS on the surface of erythrocytes as monitored by flow cytometry analysis of annexin V-FITC binding.	Phosphatidylserines	27-29	annexin A5	Homo sapiens	153-162
12820895-16	2003	Although cell lysates from yeast cells overexpressing all mutants similarly bound to phosphatidylserine (PS), an anionic lipid activator of Isc1p, G162A and G167A required 13.3 mol % PS to achieve maximum activity compared to 6.7 mol % for the wild-type enzyme, suggesting that PS might play a role in optimal catalytic efficiency of Isc1p via this P-loop-like domain.	Phosphatidylserines	85-103	inositol phosphosphingolipid phospholipase	Saccharomyces cerevisiae S288C	140-145
12820895-16	2003	Although cell lysates from yeast cells overexpressing all mutants similarly bound to phosphatidylserine (PS), an anionic lipid activator of Isc1p, G162A and G167A required 13.3 mol % PS to achieve maximum activity compared to 6.7 mol % for the wild-type enzyme, suggesting that PS might play a role in optimal catalytic efficiency of Isc1p via this P-loop-like domain.	Phosphatidylserines	105-107	inositol phosphosphingolipid phospholipase	Saccharomyces cerevisiae S288C	140-145
12820895-16	2003	Although cell lysates from yeast cells overexpressing all mutants similarly bound to phosphatidylserine (PS), an anionic lipid activator of Isc1p, G162A and G167A required 13.3 mol % PS to achieve maximum activity compared to 6.7 mol % for the wild-type enzyme, suggesting that PS might play a role in optimal catalytic efficiency of Isc1p via this P-loop-like domain.	Phosphatidylserines	183-185	inositol phosphosphingolipid phospholipase	Saccharomyces cerevisiae S288C	140-145
12820895-16	2003	Although cell lysates from yeast cells overexpressing all mutants similarly bound to phosphatidylserine (PS), an anionic lipid activator of Isc1p, G162A and G167A required 13.3 mol % PS to achieve maximum activity compared to 6.7 mol % for the wild-type enzyme, suggesting that PS might play a role in optimal catalytic efficiency of Isc1p via this P-loop-like domain.	Phosphatidylserines	183-185	inositol phosphosphingolipid phospholipase	Saccharomyces cerevisiae S288C	140-145
12832092-4	2003	Binding of the Ab-conjugated PS liposomes containing 2 or 14 mol% 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene glycol) 2000] (DSPE-PEG(2000)) to interleukin 1alpha stimulated human umbilical vein endothelial cells was 8- and 16-fold higher than those without conjugated Ab, respectively, based on the percentage relative increase in cell associated lipid for these liposomes.	Phosphatidylserines	29-31	interleukin 1 alpha	Homo sapiens	165-183
12809502-2	2003	Herein, we demonstrate that the major cobra cardiotoxin from Naja atra, CTX A3, can cause leakage of vesicle contents in phosphatidylglycerol (PG) and phosphatidylserine containing, but not in pure phosphatidylcholine (PC), membrane bilayers.	Phosphatidylserines	151-169	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	72-75
12866871-3	2003	Using this technique we distinguished between platelets and PMPs based on size and the presence of phosphatidyl serine (PS); PMPs were arbitrarily defined to be smaller than one micrometer and capable of forming a stable complex with fluorescently-labeled Annexin V, a protein that forms a calcium-dependent complex with PS.	Phosphatidylserines	321-323	annexin A5	Homo sapiens	256-265
12868350-3	2003	TF activity is highly dependent on the presence of phosphatidylserine (PS), an anionic phospholipid that is redistributed on the cell surface during apoptotic death conferring a potent procoagulant activity to the apoptotic cell.	Phosphatidylserines	51-69	coagulation factor III, tissue factor	Homo sapiens	0-2
12868350-3	2003	TF activity is highly dependent on the presence of phosphatidylserine (PS), an anionic phospholipid that is redistributed on the cell surface during apoptotic death conferring a potent procoagulant activity to the apoptotic cell.	Phosphatidylserines	71-73	coagulation factor III, tissue factor	Homo sapiens	0-2
12695484-3	2003	We show that Anx4 exhibited binding to liposomes (phosphatidylcholine:phosphatidylserine, 1:1) in the presence of Ca2+ and binding was reversible with EDTA.	Phosphatidylserines	70-88	annexin A4	Homo sapiens	13-17
12702019-8	2003	The activities of the phosphatidylserine-stimulated CDPK and of the MAPK-like were fruit developmental stage-specific with higher activities of both enzymes in the early and middle developmental stages in comparison with the late developmental stage.	Phosphatidylserines	22-40	calcium-dependent protein kinase 1	Malus domestica	52-56
12719774-5	2003	The binding activity of C-C2 to phosphatidylserine-containing phospholipid vesicles was measured by competitive binding with annexin V. The values of IC50 were approximately 70nM for both factor VIII and its light chain, but were about 7000nM for C-C2.	Phosphatidylserines	32-50	cytochrome c oxidase subunit 8A	Homo sapiens	195-199
12556460-3	2003	The PX domain of p40(phox) specifically binds phosphatidylinositol 3-phosphate, whereas the PX domain of p47(phox) has two lipid binding sites, one specific for phosphatidylinositol 3,4-bisphosphate and the other with affinity for phosphatidic acid or phosphatidylserine.	Phosphatidylserines	252-270	interleukin 9	Homo sapiens	17-20
12556460-3	2003	The PX domain of p40(phox) specifically binds phosphatidylinositol 3-phosphate, whereas the PX domain of p47(phox) has two lipid binding sites, one specific for phosphatidylinositol 3,4-bisphosphate and the other with affinity for phosphatidic acid or phosphatidylserine.	Phosphatidylserines	252-270	pleckstrin	Homo sapiens	105-108
12556460-6	2003	The membrane penetration of the p40(phox) PX domain is induced by phosphatidylinositol 3-phosphate, whereas that of the p47(phox) PX domain is triggered by both phosphatidylinositol 3,4-bisphosphate and phosphatidic acid (or phosphatidylserine).	Phosphatidylserines	225-243	interleukin 9	Homo sapiens	32-35
12556460-6	2003	The membrane penetration of the p40(phox) PX domain is induced by phosphatidylinositol 3-phosphate, whereas that of the p47(phox) PX domain is triggered by both phosphatidylinositol 3,4-bisphosphate and phosphatidic acid (or phosphatidylserine).	Phosphatidylserines	225-243	pleckstrin	Homo sapiens	120-123
12566438-5	2003	N-SMase activity was dependent on Mg(2+) and was activated by phosphatidylserine and inhibited by GW4869.	Phosphatidylserines	62-80	sphingomyelin phosphodiesterase 2	Homo sapiens	0-7
12456504-4	2003	First, Annexin V binding to phosphatidyl serine expressed on activated cells was detectable within 10 seconds of shear application.	Phosphatidylserines	28-47	annexin A5	Homo sapiens	7-16
12586747-6	2003	With mice deficient in GPVI or blocking antibodies, we found that GPVI was indispensable for collagen-dependent Ca2+ mobilization, exposure of PS, and aggregation of platelets.	Phosphatidylserines	143-145	glycoprotein 6 (platelet)	Mus musculus	66-70
12627981-4	2003	In the experimental setup chosen, the annexin A2t binding is strictly Ca2+-dependent and only affected by the amount of phosphatidylserine (PS) in the membrane and the Ca2+ concentration in solution.	Phosphatidylserines	120-138	annexin A2	Homo sapiens	38-48
12627981-4	2003	In the experimental setup chosen, the annexin A2t binding is strictly Ca2+-dependent and only affected by the amount of phosphatidylserine (PS) in the membrane and the Ca2+ concentration in solution.	Phosphatidylserines	140-142	annexin A2	Homo sapiens	38-48
12632206-1	2003	We have determined the average location and dynamic reorientation of the fluorophore 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) attached to a C12 sn-2 chain of a phosphatidylserine (PS) analogue (C12-NBD-PS) in zwitterionic phosphatidylcholine (PC) and negatively charged phosphatidylserine (PS) host membranes.	Phosphatidylserines	159-177	OXA1L mitochondrial inner membrane protein	Homo sapiens	99-104
12632206-1	2003	We have determined the average location and dynamic reorientation of the fluorophore 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) attached to a C12 sn-2 chain of a phosphatidylserine (PS) analogue (C12-NBD-PS) in zwitterionic phosphatidylcholine (PC) and negatively charged phosphatidylserine (PS) host membranes.	Phosphatidylserines	179-181	OXA1L mitochondrial inner membrane protein	Homo sapiens	99-104
12632206-1	2003	We have determined the average location and dynamic reorientation of the fluorophore 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) attached to a C12 sn-2 chain of a phosphatidylserine (PS) analogue (C12-NBD-PS) in zwitterionic phosphatidylcholine (PC) and negatively charged phosphatidylserine (PS) host membranes.	Phosphatidylserines	269-287	OXA1L mitochondrial inner membrane protein	Homo sapiens	99-104
12632206-1	2003	We have determined the average location and dynamic reorientation of the fluorophore 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) attached to a C12 sn-2 chain of a phosphatidylserine (PS) analogue (C12-NBD-PS) in zwitterionic phosphatidylcholine (PC) and negatively charged phosphatidylserine (PS) host membranes.	Phosphatidylserines	201-203	OXA1L mitochondrial inner membrane protein	Homo sapiens	99-104
12634312-7	2003	ANMB-MACS removes spermatozoa with PS-bound annexin V and produces a higher quality spermatozoal fraction.	Phosphatidylserines	35-37	annexin A5	Homo sapiens	44-53
12603829-3	2003	Compared with the controls, the INCL brains contained proportionally more phosphatidylcholine (PC), and less phosphatidylethanolamine (PE) and phosphatidylserine (PS).	Phosphatidylserines	143-161	palmitoyl-protein thioesterase 1	Homo sapiens	32-36
12603829-3	2003	Compared with the controls, the INCL brains contained proportionally more phosphatidylcholine (PC), and less phosphatidylethanolamine (PE) and phosphatidylserine (PS).	Phosphatidylserines	163-165	palmitoyl-protein thioesterase 1	Homo sapiens	32-36
12621005-1	2003	UNLABELLED: Annexin A5 is a phospholipid binding protein with high affinity for phosphatidyl-serine, which is externalized by cells undergoing programmed cell death.	Phosphatidylserines	80-99	annexin A5	Homo sapiens	12-22
12631737-4	2003	Loss of Dnf1p and Dnf2p virtually abolished ATP-dependent transport of NBD-labeled phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner plasma membrane leaflet, leaving transport of sphingolipid analogs unaffected.	Phosphatidylserines	109-127	aminophospholipid-translocating P4-type ATPase DNF1	Saccharomyces cerevisiae S288C	8-13
12631737-4	2003	Loss of Dnf1p and Dnf2p virtually abolished ATP-dependent transport of NBD-labeled phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner plasma membrane leaflet, leaving transport of sphingolipid analogs unaffected.	Phosphatidylserines	109-127	aminophospholipid-translocating P4-type ATPase DNF2	Saccharomyces cerevisiae S288C	18-23
12393532-5	2003	Disruption of this GM-CSF signaling pathway induced loss of mitochondrial membrane potential, phosphatidyl-serine exposure, and nuclear changes.	Phosphatidylserines	94-113	colony stimulating factor 2	Homo sapiens	19-25
12564925-1	2003	Phospholipid scramblase 1 (PLSCR1) is a Ca(2+)-binding, endofacial plasma membrane protein thought to contribute to the transbilayer movement of phosphatidylserine and other membrane phospholipids that is observed upon influx of calcium into the cytosol.	Phosphatidylserines	145-163	phospholipid scramblase 1	Homo sapiens	0-25
12564925-1	2003	Phospholipid scramblase 1 (PLSCR1) is a Ca(2+)-binding, endofacial plasma membrane protein thought to contribute to the transbilayer movement of phosphatidylserine and other membrane phospholipids that is observed upon influx of calcium into the cytosol.	Phosphatidylserines	145-163	phospholipid scramblase 1	Homo sapiens	27-33
12407104-6	2003	When incubated in the presence of phosphatidylserine, phorbol 12,13-dibutyrate and ATP, intact PKD slowly autophosphorylated in the activation loop but only at Ser(748).	Phosphatidylserines	34-52	protein kinase D1	Homo sapiens	95-98
14555787-5	2003	Annexin-A5, a native plasma protein with a high affinity for PS, can be used to measure this mode of cell death.	Phosphatidylserines	61-63	annexin A5	Homo sapiens	0-10
12673936-6	2003	Immunolabeling of biotin-conjugated Annexin V is used for the identification of phosphatidylserine residues exposed on the surface of AP cells.	Phosphatidylserines	80-98	annexin A5	Homo sapiens	36-45
14692561-3	2003	The fractions of lysophosphatidylcholine, sphingomyelin, phosphatidylserine plus phosphatidylinositol, and phosphatidylglycerol dose-dependently inhibited the aggregation of washed rabbit platelets induced by PAF.	Phosphatidylserines	57-75	PCNA-associated factor	Bos taurus	209-212
14604010-8	2003	In mammalian cells, PS is synthesized on the ER and/or mitochondria-associated membranes (MAM).	Phosphatidylserines	20-22	sarcoglycan gamma	Homo sapiens	90-93
14604010-10	2003	Since MAM are a region of the ER that appears to be in close juxtaposition to the mitochondrial outer membrane, it has been proposed that MAM act as a conduit for the transfer of newly synthesized PS into mitochondria.	Phosphatidylserines	197-199	sarcoglycan gamma	Homo sapiens	6-9
14604010-10	2003	Since MAM are a region of the ER that appears to be in close juxtaposition to the mitochondrial outer membrane, it has been proposed that MAM act as a conduit for the transfer of newly synthesized PS into mitochondria.	Phosphatidylserines	197-199	sarcoglycan gamma	Homo sapiens	138-141
12540960-4	2003	LB30057 suppressed significantly thrombin-induced phosphatidylserine (PS) exposure in platelets, suggesting that LB30057 could inhibit blood coagulation accelerated by PS exposure.	Phosphatidylserines	50-68	coagulation factor II, thrombin	Homo sapiens	33-41
12526092-2	2002	We earlier observed that yeast recombinant deoxyhypusine synthase was phosphorylated by protein kinase C (PKC) in vitro (Kang and Chung, 1999) and the phosphorylation rate was synergistically increased to a 3.5-fold following treatment with phosphatidylserine (P.Ser)/diacylglycerol (DAG)/ Ca(2+), suggesting a possible involvement of PKC.	Phosphatidylserines	241-259	deoxyhypusine synthase	Saccharomyces cerevisiae S288C	43-65
12450402-2	2002	Using ellipsometry, we characterized prothrombin-mediated binding of lupus anticoagulant (LA) positive IgG, isolated from patients with antiphospholipid syndrome, to phosphatidylserine (PS)-containing membranes.	Phosphatidylserines	166-184	coagulation factor II, thrombin	Homo sapiens	37-48
12450402-2	2002	Using ellipsometry, we characterized prothrombin-mediated binding of lupus anticoagulant (LA) positive IgG, isolated from patients with antiphospholipid syndrome, to phosphatidylserine (PS)-containing membranes.	Phosphatidylserines	186-188	coagulation factor II, thrombin	Homo sapiens	37-48
12450402-4	2002	Adsorption to membranes containing 10-40 mol % PS revealed that membrane-bound rather than solution-phase prothrombin determines the adsorption kinetics.	Phosphatidylserines	47-49	coagulation factor II, thrombin	Homo sapiens	106-117
12244059-1	2002	Yeast ISC1 (Yer019w) encodes inositolphosphosphingolipid-phospholipase C and is activated by phosphatidylserine (PS) and cardiolipin (CL) (Sawai, H., Okamoto, Y., Lubert, C., Mao, C., Bielawska, A., Domae, M., and Hannun, Y.	Phosphatidylserines	93-111	inositol phosphosphingolipid phospholipase	Saccharomyces cerevisiae S288C	6-10
12244059-1	2002	Yeast ISC1 (Yer019w) encodes inositolphosphosphingolipid-phospholipase C and is activated by phosphatidylserine (PS) and cardiolipin (CL) (Sawai, H., Okamoto, Y., Lubert, C., Mao, C., Bielawska, A., Domae, M., and Hannun, Y.	Phosphatidylserines	113-115	inositol phosphosphingolipid phospholipase	Saccharomyces cerevisiae S288C	6-10
12244059-7	2002	FLAG-tagged Isc1p was activated by PS, CL, and phosphatidylglycerol (PG) in a dose-dependent manner.	Phosphatidylserines	35-37	inositol phosphosphingolipid phospholipase	Saccharomyces cerevisiae S288C	12-17
12244059-8	2002	Using lipid-protein overlay assays, Isc1p interacted specifically and directly with PS/CL/PG.	Phosphatidylserines	84-86	inositol phosphosphingolipid phospholipase	Saccharomyces cerevisiae S288C	36-41
12244059-11	2002	In addition, mutations of positively charged amino acid residues at the C terminus of ISC1 reduced the activating effects of PS, suggesting involvement of these amino acids in interaction with PS/CL/PG and in the activation of the enzyme.	Phosphatidylserines	125-127	inositol phosphosphingolipid phospholipase	Saccharomyces cerevisiae S288C	86-90
12244059-11	2002	In addition, mutations of positively charged amino acid residues at the C terminus of ISC1 reduced the activating effects of PS, suggesting involvement of these amino acids in interaction with PS/CL/PG and in the activation of the enzyme.	Phosphatidylserines	193-195	inositol phosphosphingolipid phospholipase	Saccharomyces cerevisiae S288C	86-90
12244059-13	2002	These results raise the hypothesis that in the presence of PS/CL/PG, the catalytic domain in the N terminus of Isc1p is "pulled" to the membrane to interact with substrate.	Phosphatidylserines	59-61	inositol phosphosphingolipid phospholipase	Saccharomyces cerevisiae S288C	111-116
12417016-1	2002	The gamma isotype of protein kinase C (PKC gamma) is a member of the classical PKC (cPKC) subfamily which is activated by Ca(2+) and diacylglycerol in the presence of phosphatidylserine.	Phosphatidylserines	167-185	protein kinase C, gamma	Mus musculus	39-48
12417016-1	2002	The gamma isotype of protein kinase C (PKC gamma) is a member of the classical PKC (cPKC) subfamily which is activated by Ca(2+) and diacylglycerol in the presence of phosphatidylserine.	Phosphatidylserines	167-185	protein kinase C, alpha	Mus musculus	39-42
12369848-8	2002	Inhibition of PKC with either calphostin C, a blocker of the PMA binding site, or chelerythrine chloride, an inhibitor of the active site, diminished the level of formation of PS-exposing cells.	Phosphatidylserines	176-178	proline rich transmembrane protein 2	Homo sapiens	14-17
12374627-4	2002	Ferryl Mb formation correlated with the induction of apoptosis as indicated by morphological criteria, caspase 3 activation, phosphatidylserine (PS) externalization, and nuclear condensation by Hoechst 33342 staining.	Phosphatidylserines	125-143	myoglobin	Bos taurus	7-9
12388589-7	2002	Activation of PKCbeta2 in vitro by phosphatidylserine/diacylglycerol or in hippocampal slices by metabotropic glutamate receptor stimulation increased the amount of RACK1/PKCbeta2 associated with polysome-bound polyA-mRNAs.	Phosphatidylserines	35-53	receptor for activated C kinase 1	Homo sapiens	165-170
12269833-5	2002	Inhibition of PKC by BP-7,8-dione was observed irrespective of whether PKCalpha activity was stimulated with phorbol 12-myristate 13-acetate (PMA), phosphatidylserine (PS), or Ca(2+) or whether PKCdelta was stimulated with phorbol 12-myristate 13-acetate (PMA) or phosphatidylserine (PS), suggesting that the inhibition was not cofactor-specific.	Phosphatidylserines	168-170	proline rich transmembrane protein 2	Homo sapiens	14-17
12356722-3	2002	These two pockets have different specificities: one preferentially binds phosphatidylinositol 3,4-bisphosphate [PtdIns(3,4)P(2)] and is analogous to the phophatidylinositol 3-phosphate (PtdIns3P)-binding pocket of p40(phox), while the other binds anionic phospholipids such as phosphatidic acid (PtdOH) or phosphatidylserine.	Phosphatidylserines	306-324	interleukin 9	Homo sapiens	214-217
12356722-3	2002	These two pockets have different specificities: one preferentially binds phosphatidylinositol 3,4-bisphosphate [PtdIns(3,4)P(2)] and is analogous to the phophatidylinositol 3-phosphate (PtdIns3P)-binding pocket of p40(phox), while the other binds anionic phospholipids such as phosphatidic acid (PtdOH) or phosphatidylserine.	Phosphatidylserines	306-324	pleckstrin	Homo sapiens	218-222
12234184-5	2002	When phosphatidylserine-containing membranes are present, Ca(2+) affinities range from the sub-micromolar to the micromolar (7-fold difference) ([Ca(2+)](1/2) = 0.7 +/- 0.1 microM for PKC gamma, 1.4 +/- 0.1 microM for PKC alpha, and 5.0 +/- 0.2 microM for PKC beta), and cooperative Ca(2+) binding is observed for all three C2 domains (Hill coefficients equal 1.8 +/- 0.1 for PKC beta, 1.3 +/- 0.1 for PKC alpha, and 1.4 +/- 0.1 for PKC gamma).	Phosphatidylserines	5-23	protein kinase C gamma	Homo sapiens	184-193
12234184-5	2002	When phosphatidylserine-containing membranes are present, Ca(2+) affinities range from the sub-micromolar to the micromolar (7-fold difference) ([Ca(2+)](1/2) = 0.7 +/- 0.1 microM for PKC gamma, 1.4 +/- 0.1 microM for PKC alpha, and 5.0 +/- 0.2 microM for PKC beta), and cooperative Ca(2+) binding is observed for all three C2 domains (Hill coefficients equal 1.8 +/- 0.1 for PKC beta, 1.3 +/- 0.1 for PKC alpha, and 1.4 +/- 0.1 for PKC gamma).	Phosphatidylserines	5-23	protein kinase C alpha	Homo sapiens	218-227
12234184-5	2002	When phosphatidylserine-containing membranes are present, Ca(2+) affinities range from the sub-micromolar to the micromolar (7-fold difference) ([Ca(2+)](1/2) = 0.7 +/- 0.1 microM for PKC gamma, 1.4 +/- 0.1 microM for PKC alpha, and 5.0 +/- 0.2 microM for PKC beta), and cooperative Ca(2+) binding is observed for all three C2 domains (Hill coefficients equal 1.8 +/- 0.1 for PKC beta, 1.3 +/- 0.1 for PKC alpha, and 1.4 +/- 0.1 for PKC gamma).	Phosphatidylserines	5-23	protein kinase C beta	Homo sapiens	256-264
12234184-5	2002	When phosphatidylserine-containing membranes are present, Ca(2+) affinities range from the sub-micromolar to the micromolar (7-fold difference) ([Ca(2+)](1/2) = 0.7 +/- 0.1 microM for PKC gamma, 1.4 +/- 0.1 microM for PKC alpha, and 5.0 +/- 0.2 microM for PKC beta), and cooperative Ca(2+) binding is observed for all three C2 domains (Hill coefficients equal 1.8 +/- 0.1 for PKC beta, 1.3 +/- 0.1 for PKC alpha, and 1.4 +/- 0.1 for PKC gamma).	Phosphatidylserines	5-23	protein kinase C beta	Homo sapiens	376-384
12234184-5	2002	When phosphatidylserine-containing membranes are present, Ca(2+) affinities range from the sub-micromolar to the micromolar (7-fold difference) ([Ca(2+)](1/2) = 0.7 +/- 0.1 microM for PKC gamma, 1.4 +/- 0.1 microM for PKC alpha, and 5.0 +/- 0.2 microM for PKC beta), and cooperative Ca(2+) binding is observed for all three C2 domains (Hill coefficients equal 1.8 +/- 0.1 for PKC beta, 1.3 +/- 0.1 for PKC alpha, and 1.4 +/- 0.1 for PKC gamma).	Phosphatidylserines	5-23	protein kinase C alpha	Homo sapiens	402-411
12234184-5	2002	When phosphatidylserine-containing membranes are present, Ca(2+) affinities range from the sub-micromolar to the micromolar (7-fold difference) ([Ca(2+)](1/2) = 0.7 +/- 0.1 microM for PKC gamma, 1.4 +/- 0.1 microM for PKC alpha, and 5.0 +/- 0.2 microM for PKC beta), and cooperative Ca(2+) binding is observed for all three C2 domains (Hill coefficients equal 1.8 +/- 0.1 for PKC beta, 1.3 +/- 0.1 for PKC alpha, and 1.4 +/- 0.1 for PKC gamma).	Phosphatidylserines	5-23	protein kinase C gamma	Homo sapiens	433-442
12231555-4	2002	When it was found that phosphatidylserine containing lipid extracts could be substituted for platelets in clotting assays, this suggested the possibility that changes in platelet lipid composition were necessary and sufficient to account for platelet surface thrombin generation.	Phosphatidylserines	23-41	coagulation factor II, thrombin	Homo sapiens	259-267
12153579-1	2002	An unconventional phospholipase D (PLD) activity was identified recently in Saccharomyces cerevisiae which is Ca2+-dependent, preferentially hydrolyses phosphatidylethanolamine (PtdEtn) and phosphatidylserine and does not catalyse a transphosphatidylation with primary short-chain alcohols.	Phosphatidylserines	190-208	phospholipase D	Saccharomyces cerevisiae S288C	18-33
12153579-1	2002	An unconventional phospholipase D (PLD) activity was identified recently in Saccharomyces cerevisiae which is Ca2+-dependent, preferentially hydrolyses phosphatidylethanolamine (PtdEtn) and phosphatidylserine and does not catalyse a transphosphatidylation with primary short-chain alcohols.	Phosphatidylserines	190-208	phospholipase D	Saccharomyces cerevisiae S288C	35-38
12194751-4	2002	MATERIALS AND METHODS: Using a four-colour flow-cytometry method, which measures annexin-V binding to phosphatidyl serine and propidium iodide, spontaneous and radiation-induced apoptosis was measured in the total lymphocyte fraction and in CD4(+) and CD8(+) T-cell subpopulations.	Phosphatidylserines	102-121	annexin A5	Homo sapiens	81-90
12153489-11	2002	From these data, we suggest that the antiapoptotic effect of DHA is mediated at least in part through the PI3-K/Akt pathway, facilitated by DHA-induced PS accumulation.	Phosphatidylserines	152-154	thymoma viral proto-oncogene 1	Mus musculus	112-115
12135736-2	2002	We hypothesized that catalytic redox interactions between negatively charged phosphatidylserine (PS) and positively charged cytochrome c released into the cytosol, along with the production of reactive oxygen species (ROS), results in pronounced oxidation and externalization of PS, and subsequent recognition of apoptotic cells by macrophages.	Phosphatidylserines	97-99	cytochrome c, somatic	Homo sapiens	124-136
12135736-2	2002	We hypothesized that catalytic redox interactions between negatively charged phosphatidylserine (PS) and positively charged cytochrome c released into the cytosol, along with the production of reactive oxygen species (ROS), results in pronounced oxidation and externalization of PS, and subsequent recognition of apoptotic cells by macrophages.	Phosphatidylserines	279-281	cytochrome c, somatic	Homo sapiens	124-136
12016218-2	2002	Our previous studies have indicated that class B scavenger receptor type I (SR-BI) is responsible for the PS-mediated phagocytosis by Sertoli cells.	Phosphatidylserines	106-108	scavenger receptor class B member 1	Homo sapiens	76-81
12016218-3	2002	We examined here whether SR-BI binds directly to PS.	Phosphatidylserines	49-51	scavenger receptor class B member 1	Homo sapiens	25-30
12016218-4	2002	A cell line acquired the ability to bind to PS-exposing apoptotic cells and to incorporate PS-containing liposomes when it was forced to express SR-BI.	Phosphatidylserines	91-93	scavenger receptor class B member 1	Homo sapiens	145-150
12016218-5	2002	Furthermore, the extracellular domain of rat SR-BI fused with human Fc (SRBIecd-Fc) bound to PS with a dissociation equilibrium constant of 2.4 x 10(-7) m in a cell-free solid-phase assay, whereas other phospholipids including phosphatidylethanolamine, phosphatidylinositol, and phosphatidylcholine were poor binding targets.	Phosphatidylserines	93-95	scavenger receptor class B, member 1	Rattus norvegicus	45-50
11953426-9	2002	Since ceramides also support formation of rafts and interact with Raf we propose that Raf may be present at the plasma membrane in two distinct microdomains: in raft regions via association with cholesterol and ceramides and in non-raft regions due to interaction with phosphatidylserine and phosphatidic acid.	Phosphatidylserines	269-287	zinc fingers and homeoboxes 2	Homo sapiens	86-89
12058279-8	2002	These results indicate that annexin V inhibited the phagocytic clearance of apoptotic spermatogenic cells and suggest that PS-mediated phagocytosis of those cells occurs in vivo.	Phosphatidylserines	123-125	annexin A5	Mus musculus	28-37
12077280-5	2002	Phagocytosis of Fas-triggered Jurkat cells was inhibited by superoxide dismutase and catalase, which prevent oxidation of PS while allowing PS to remain externalized on these cells.	Phosphatidylserines	122-124	catalase	Homo sapiens	85-93
12077280-5	2002	Phagocytosis of Fas-triggered Jurkat cells was inhibited by superoxide dismutase and catalase, which prevent oxidation of PS while allowing PS to remain externalized on these cells.	Phosphatidylserines	140-142	catalase	Homo sapiens	85-93
12097146-3	2002	In the current study, we investigate the binding of Boi1"s PH domain to the acidic phospholipids PIP2 (phosphatidylinositol-4,5-bisphosphate) and PS (phosphatidylserine).	Phosphatidylserines	146-148	Boi1p	Saccharomyces cerevisiae S288C	52-56
12097146-3	2002	In the current study, we investigate the binding of Boi1"s PH domain to the acidic phospholipids PIP2 (phosphatidylinositol-4,5-bisphosphate) and PS (phosphatidylserine).	Phosphatidylserines	150-168	Boi1p	Saccharomyces cerevisiae S288C	52-56
12097146-7	2002	Amino-acid substitutions that diminish binding to PIP2 and PS impair Boi1 function.	Phosphatidylserines	59-61	Boi1p	Saccharomyces cerevisiae S288C	69-73
12097146-10	2002	Amino-acid substitutions that diminish binding to PIP2 and PS impair localization of Boi1 to the bud, but do not affect the localization of Boi1 to the neck.	Phosphatidylserines	59-61	Boi1p	Saccharomyces cerevisiae S288C	85-89
12060396-7	2002	Using fluorescamine derivatization and annexin V binding it was observed that specific oxidation of phosphatidylserine was accompanied by phosphatidylserine translocation from the inner to the outer plasma membrane surface where it may serve as a recognition signal for interaction with phagocytic macrophages.	Phosphatidylserines	100-118	annexin A5	Homo sapiens	39-48
11992734-4	2002	Flow cytometric analysis of the externalization of phosphatidylserine (PS) using the annexin V/PI method on altholactone treated HL-60 cells showed a concentration-dependent increase of apoptosis from concentrations ranging from 10.8 (2.5 microg/ml) to 172.4 microM (40 microg/ml).	Phosphatidylserines	51-69	annexin A5	Homo sapiens	85-94
11893753-1	2002	The following two theories for the mechanism of ABCA1 in lipid efflux to apolipoprotein acceptors have been proposed: 1) that ABCA1 directly binds the apolipoprotein ligand and then facilitates lipid efflux and 2) that ABCA1 acts as a phosphatidylserine (PS) translocase, increasing PS levels in the plasma membrane exofacial leaflet, and that this is sufficient to facilitate apolipoprotein binding and lipid assembly.	Phosphatidylserines	255-257	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	48-53
11893753-1	2002	The following two theories for the mechanism of ABCA1 in lipid efflux to apolipoprotein acceptors have been proposed: 1) that ABCA1 directly binds the apolipoprotein ligand and then facilitates lipid efflux and 2) that ABCA1 acts as a phosphatidylserine (PS) translocase, increasing PS levels in the plasma membrane exofacial leaflet, and that this is sufficient to facilitate apolipoprotein binding and lipid assembly.	Phosphatidylserines	255-257	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	126-131
11893753-1	2002	The following two theories for the mechanism of ABCA1 in lipid efflux to apolipoprotein acceptors have been proposed: 1) that ABCA1 directly binds the apolipoprotein ligand and then facilitates lipid efflux and 2) that ABCA1 acts as a phosphatidylserine (PS) translocase, increasing PS levels in the plasma membrane exofacial leaflet, and that this is sufficient to facilitate apolipoprotein binding and lipid assembly.	Phosphatidylserines	255-257	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	126-131
11893753-2	2002	Upon induction of ABCA1 in RAW264.7 cells by cAMP analogues there was a moderate increase in cell surface PS as detected by annexin V binding, whereas apoAI binding was increased more robustly.	Phosphatidylserines	106-108	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	18-23
11893753-2	2002	Upon induction of ABCA1 in RAW264.7 cells by cAMP analogues there was a moderate increase in cell surface PS as detected by annexin V binding, whereas apoAI binding was increased more robustly.	Phosphatidylserines	106-108	annexin A5	Mus musculus	124-133
12000961-5	2002	MFG-E8 specifically bound to apoptotic cells by recognizing aminophospholipids such as phosphatidylserine.	Phosphatidylserines	87-105	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	0-6
12148244-7	2002	In contrast, both E1B 55K and Bcl-2 allowed cell survival and prevented the typical features of programmed cell death, such as phosphatidyl-serine exposure, loss of mitochondrial membrane potential, and chromatin condensation and fragmentation.	Phosphatidylserines	127-146	BCL2 apoptosis regulator	Homo sapiens	30-35
11994533-12	2002	The Bolton-Hunter-labeled annexin V bound to apoptotic cells and immobilized phosphatidylserine in vitro.	Phosphatidylserines	77-95	annexin A5	Mus musculus	26-35
12162425-0	2002	Depletion of Bcl-2 by an antisense oligonucleotide induces apoptosis accompanied by oxidation and externalization of phosphatidylserine in NCI-H226 lung carcinoma cells.	Phosphatidylserines	117-135	BCL2 apoptosis regulator	Homo sapiens	13-18
12162425-6	2002	We found a decrease in Bcl-2 was associated with a selective oxidation of PS in a sub-population of the cells with externalized PS.	Phosphatidylserines	74-76	BCL2 apoptosis regulator	Homo sapiens	23-28
12162425-6	2002	We found a decrease in Bcl-2 was associated with a selective oxidation of PS in a sub-population of the cells with externalized PS.	Phosphatidylserines	128-130	BCL2 apoptosis regulator	Homo sapiens	23-28
12162425-9	2002	These metabolic and topographical changes in PS arrangement in plasma membrane appear to be early responses to antisense bcl-2 exposure that trigger a PS-dependent apoptotic signaling pathway.	Phosphatidylserines	45-47	BCL2 apoptosis regulator	Homo sapiens	121-126
12162425-9	2002	These metabolic and topographical changes in PS arrangement in plasma membrane appear to be early responses to antisense bcl-2 exposure that trigger a PS-dependent apoptotic signaling pathway.	Phosphatidylserines	151-153	BCL2 apoptosis regulator	Homo sapiens	121-126
11969429-9	2002	We conclude that PS regulates both the cofactor and the enzyme of the prothrombin-activating complex.	Phosphatidylserines	17-19	coagulation factor II, thrombin	Bos taurus	70-81
11999952-4	2002	Annexin V is a naturally occurring human protein that binds avidly to membrane-associated phosphatidylserine (PS).	Phosphatidylserines	90-108	annexin A5	Homo sapiens	0-9
11999952-4	2002	Annexin V is a naturally occurring human protein that binds avidly to membrane-associated phosphatidylserine (PS).	Phosphatidylserines	110-112	annexin A5	Homo sapiens	0-9
11999952-5	2002	PS is normally found only on the inner leaflet of the cell membrane double layer, but it is actively transported to the outer layer as an early event in apoptosis and becomes available for annexin binding.	Phosphatidylserines	0-2	annexin A11, opposite strand	Mus musculus	189-196
11999952-6	2002	Annexin also gains access to PS as a result of the membrane fragmentation associated with necrosis.	Phosphatidylserines	29-31	annexin A11, opposite strand	Mus musculus	0-7
11868812-4	2002	All incubation conditions led to a time-dependent, significant decline in sperm motion parameters and an increase in exposure of phosphatidylserine (annexin V+, live cells) to the outer leaflet of the plasma membrane in both patients and donors.	Phosphatidylserines	129-147	annexin A5	Homo sapiens	149-158
11895038-6	2002	The presence of PS-liposomes strongly reduced the release of pro-inflammatory molecules such as nitric oxide, interleukin-1beta, and tumor necrosis factor-alpha by LPS-activated microglia.	Phosphatidylserines	16-18	interleukin 1 beta	Rattus norvegicus	110-127
11895038-6	2002	The presence of PS-liposomes strongly reduced the release of pro-inflammatory molecules such as nitric oxide, interleukin-1beta, and tumor necrosis factor-alpha by LPS-activated microglia.	Phosphatidylserines	16-18	tumor necrosis factor	Rattus norvegicus	133-160
11934394-1	2002	Addition of a small amount of ganglioside GM(1) to phosphatidylserine (PS) liposomes, a gradual increase of protein kinase C (PKC) activity was recorded up to about 2 mol% GM(1) where the maximal enzyme activity was obtained.	Phosphatidylserines	51-69	proline rich transmembrane protein 2	Homo sapiens	108-124
11934394-1	2002	Addition of a small amount of ganglioside GM(1) to phosphatidylserine (PS) liposomes, a gradual increase of protein kinase C (PKC) activity was recorded up to about 2 mol% GM(1) where the maximal enzyme activity was obtained.	Phosphatidylserines	51-69	proline rich transmembrane protein 2	Homo sapiens	126-129
11991237-4	2002	Exposure of PS on platelets obtained from patients with P vera and ET and from age- and sex-matched healthy volunteers was measured by fluorescein-labeled Annexin V binding to platelets and by the platelets" thrombin-generating capacity determined by the prothrombinase assay.	Phosphatidylserines	12-14	annexin A5	Homo sapiens	155-164
11991237-4	2002	Exposure of PS on platelets obtained from patients with P vera and ET and from age- and sex-matched healthy volunteers was measured by fluorescein-labeled Annexin V binding to platelets and by the platelets" thrombin-generating capacity determined by the prothrombinase assay.	Phosphatidylserines	12-14	coagulation factor II, thrombin	Homo sapiens	208-216
11774346-15	2002	Detection of PS asymmetry by AnV-fluorescein isothiocyanate (FITC) is not always associated with (inevitable) apoptosis, as can be concluded from the proliferative capacity of AnV+ /PI- CD34+ cells in the SCSW assay.	Phosphatidylserines	13-15	CD34 molecule	Homo sapiens	186-190
11902115-7	2002	Of special interest was the prevalence of phospholipids (phosphatidylcholine, diacyl-phosphatidylethanolamine, and phosphatidylserine) with 22:6n-3 in both the sn-1 and sn-2 positions of SPM and these phospholipid species were significantly higher in apoE-deficient mice as compared to control mice.	Phosphatidylserines	115-133	solute carrier family 38, member 3	Mus musculus	160-164
11602607-1	2001	Two yeast enzymes, Psd1p and Psd2p, catalyze the decarboxylation of phosphatidylserine to produce phosphatidylethanolamine (PtdEtn).	Phosphatidylserines	68-86	phosphatidylserine decarboxylase 1	Saccharomyces cerevisiae S288C	19-24
11602607-1	2001	Two yeast enzymes, Psd1p and Psd2p, catalyze the decarboxylation of phosphatidylserine to produce phosphatidylethanolamine (PtdEtn).	Phosphatidylserines	68-86	phosphatidylserine decarboxylase 2	Saccharomyces cerevisiae S288C	29-34
11719358-8	2001	In contrast, correlations were noted between PS-positive erythrocytes and F1.2 (P &lt;.0002), D-dimer (P &lt;.000002), and PAP (P &lt;.01).	Phosphatidylserines	45-47	coagulation factor XII	Homo sapiens	74-78
11726314-10	2001	Thrombotic events in hemolytic anemias with membrane defects have been attributed, at least in part, to hypercoagulability related to the exposure of phosphatidylserine of red cell membrane activating plasma prothrombinase and supplying a procoagulant phospholipid anionic surface.	Phosphatidylserines	150-168	coagulation factor X	Homo sapiens	208-222
11705379-0	2001	Identification of the phosphatidylserine binding site in the C2 domain that is important for PKC alpha activation and in vivo cell localization.	Phosphatidylserines	22-40	protein kinase C alpha	Homo sapiens	93-102
11706053-0	2001	Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells.	Phosphatidylserines	0-18	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	32-43
11706053-0	2001	Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells.	Phosphatidylserines	20-22	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	32-43
11706053-5	2001	Further, recognition of PS was found to be dependent on the presence of the PS receptor (PSR).	Phosphatidylserines	24-26	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	76-87
11706053-5	2001	Further, recognition of PS was found to be dependent on the presence of the PS receptor (PSR).	Phosphatidylserines	24-26	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	89-92
11544256-11	2001	The most notable of the altered phospholipid compositions of the gat1Delta and gat2(sct1)Delta strains are a decreased phosphatidic acid pool and an increased phosphatidylserine/phosphatidylinositol ratio.	Phosphatidylserines	159-177	Gat2p	Saccharomyces cerevisiae S288C	79-83
11544256-11	2001	The most notable of the altered phospholipid compositions of the gat1Delta and gat2(sct1)Delta strains are a decreased phosphatidic acid pool and an increased phosphatidylserine/phosphatidylinositol ratio.	Phosphatidylserines	159-177	bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1	Saccharomyces cerevisiae S288C	84-88
11668053-3	2001	Annexin V binds phosphatidylserine, a phosphoaminolipid thought to be externalized during apoptosis or programmed cell death.	Phosphatidylserines	16-34	annexin A5	Rattus norvegicus	0-9
11911269-5	2001	Furthermore, flow cytofluorimetry studies with external phosphatidylserine labelling showed that P-gp and MRP1 overexpressions have strong but differentiated effects on cell lipid pools.	Phosphatidylserines	56-74	ATP binding cassette subfamily B member 1	Homo sapiens	97-101
11911269-5	2001	Furthermore, flow cytofluorimetry studies with external phosphatidylserine labelling showed that P-gp and MRP1 overexpressions have strong but differentiated effects on cell lipid pools.	Phosphatidylserines	56-74	ATP binding cassette subfamily C member 1	Homo sapiens	106-110
11703340-8	2001	Both thrombin generation and tissue factor activity were blocked by the addition of annexin V, which binds and inhibits phosphatidylserine.	Phosphatidylserines	120-138	coagulation factor II, thrombin	Homo sapiens	5-13
11703340-8	2001	Both thrombin generation and tissue factor activity were blocked by the addition of annexin V, which binds and inhibits phosphatidylserine.	Phosphatidylserines	120-138	annexin A5	Homo sapiens	84-93
11760098-4	2001	The cell death was confirmed to be apoptosis by Annexin V binding to phosphatidylserine in the cell membrane and excluding propidium iodide.	Phosphatidylserines	69-87	annexin A5	Mus musculus	48-57
11687240-6	2001	Attractors software was used to quantitate the percentage of apoptotic CD4 T cells, which generate reactive oxygen species (ROS), express external phosphatidyl serine (PS) and cleaved fluorescein diacetate (FDA), within the intact and compromised lymphocyte populations.	Phosphatidylserines	147-166	CD4 molecule	Homo sapiens	71-74
11687240-6	2001	Attractors software was used to quantitate the percentage of apoptotic CD4 T cells, which generate reactive oxygen species (ROS), express external phosphatidyl serine (PS) and cleaved fluorescein diacetate (FDA), within the intact and compromised lymphocyte populations.	Phosphatidylserines	168-170	CD4 molecule	Homo sapiens	71-74
11568012-7	2001	IL-5 and the cell-permeable caspase inhibitor, benzyloxycarbonyl-Val-Ala-Asp-(OMe) fluoromethyl ketone (z-VAD.fmk), prevented phosphatidylserine (PS) externalization, although only IL-5 inhibited loss of mitochondrial membrane potential (DeltaPsim).	Phosphatidylserines	126-144	interleukin 5	Homo sapiens	0-4
11568012-7	2001	IL-5 and the cell-permeable caspase inhibitor, benzyloxycarbonyl-Val-Ala-Asp-(OMe) fluoromethyl ketone (z-VAD.fmk), prevented phosphatidylserine (PS) externalization, although only IL-5 inhibited loss of mitochondrial membrane potential (DeltaPsim).	Phosphatidylserines	126-144	interleukin 5	Homo sapiens	181-185
11781185-3	2001	We report that the inhibition of the B lymphoma cell WEHI-279-proliferation induced by IFN-gamma, involves the induction of typical features of apoptosis (nuclear chromatin condensation and fragmentation, cell shrinkage, phosphatidyl-serine (PS) exposure and mitochondrial membrane potential (delta psim) loss).	Phosphatidylserines	221-240	interferon gamma	Mus musculus	87-96
11781185-3	2001	We report that the inhibition of the B lymphoma cell WEHI-279-proliferation induced by IFN-gamma, involves the induction of typical features of apoptosis (nuclear chromatin condensation and fragmentation, cell shrinkage, phosphatidyl-serine (PS) exposure and mitochondrial membrane potential (delta psim) loss).	Phosphatidylserines	242-244	interferon gamma	Mus musculus	87-96
11574507-5	2001	Annexin V binding was used to assess membrane translocation of phosphatidylserine (PS).	Phosphatidylserines	63-81	annexin A5	Homo sapiens	0-9
11574507-5	2001	Annexin V binding was used to assess membrane translocation of phosphatidylserine (PS).	Phosphatidylserines	83-85	annexin A5	Homo sapiens	0-9
11527403-4	2001	Subsequent analysis revealed that overexpression of hFAF1 induced nuclear condensation, appearance of phosphatidylserines in the outer leaflet of the cellular membrane, and caspase 3 activation.	Phosphatidylserines	102-121	Fas associated factor 1	Homo sapiens	52-57
11543641-6	2001	These data provide evidence for Z-VAD.FMK-insensitive and caspases-3/-7-independent pathway(s) in the externalization of PS and cytoplasmic changes during HQ-induced apoptosis in HL-60 cells.	Phosphatidylserines	121-123	caspase 3	Homo sapiens	58-71
11522300-6	2001	These results suggest that PS-induced apoptosis occurs without the collapse of mitochondrial transmembrane potential and without the release of cytochrome c, in a manner independent of caspase-1, -3, -8 and -9.	Phosphatidylserines	27-29	cytochrome c	Cricetulus griseus	144-156
11522300-6	2001	These results suggest that PS-induced apoptosis occurs without the collapse of mitochondrial transmembrane potential and without the release of cytochrome c, in a manner independent of caspase-1, -3, -8 and -9.	Phosphatidylserines	27-29	caspase-1	Cricetulus griseus	185-209
11493474-5	2001	Blocking of Fas protein reduced the number of apoptotic cells in the liver; binding of annexin V to phosphatidylserine (PS) reduced the number of PMNs phagocytosed by Kupffer cells.	Phosphatidylserines	100-118	annexin A5	Rattus norvegicus	87-96
11493474-5	2001	Blocking of Fas protein reduced the number of apoptotic cells in the liver; binding of annexin V to phosphatidylserine (PS) reduced the number of PMNs phagocytosed by Kupffer cells.	Phosphatidylserines	120-122	annexin A5	Rattus norvegicus	87-96
11468189-3	2001	Within the light RBC fraction, PS exposure was found on reticulocytes, transferrin receptor-expressing reticulocytes, and mature RBCs.	Phosphatidylserines	31-33	transferrin	Homo sapiens	71-82
11467926-3	2001	We show that lipid peroxidation of RBC generates MDA adducts that, similar to phosphatidylserine (PS), bind annexin V in a Ca(2+)-dependent manner.	Phosphatidylserines	78-96	annexin A5	Homo sapiens	108-117
11467926-3	2001	We show that lipid peroxidation of RBC generates MDA adducts that, similar to phosphatidylserine (PS), bind annexin V in a Ca(2+)-dependent manner.	Phosphatidylserines	98-100	annexin A5	Homo sapiens	108-117
11521886-3	2001	Then the FQ labeled PS (FQ-PS) was used as the fluorescent probe for monitoring the association between PS and bovine serum albumin (BSA).	Phosphatidylserines	20-22	albumin	Homo sapiens	118-131
11521886-3	2001	Then the FQ labeled PS (FQ-PS) was used as the fluorescent probe for monitoring the association between PS and bovine serum albumin (BSA).	Phosphatidylserines	27-29	albumin	Homo sapiens	118-131
11442313-8	2001	Digestion of control SR with phospholipase A2 decreased [3H]ryanodine binding and the decrease was reversible by the addition of phosphatidylcholine (PC), phosphatidylethanolamine (PE), or phosphatidylserine (PS).	Phosphatidylserines	189-207	phospholipase A2 group IB	Rattus norvegicus	29-45
11442313-8	2001	Digestion of control SR with phospholipase A2 decreased [3H]ryanodine binding and the decrease was reversible by the addition of phosphatidylcholine (PC), phosphatidylethanolamine (PE), or phosphatidylserine (PS).	Phosphatidylserines	209-211	phospholipase A2 group IB	Rattus norvegicus	29-45
11487033-3	2001	TF activity is highly dependent on the presence of phosphatidylserine (PS), an anionic phospholipid that is redistributed on the cell surface during apoptotic death conferring a potent procoagulant activity to the apoptotic cell.	Phosphatidylserines	51-69	coagulation factor III, tissue factor	Homo sapiens	0-2
11487033-3	2001	TF activity is highly dependent on the presence of phosphatidylserine (PS), an anionic phospholipid that is redistributed on the cell surface during apoptotic death conferring a potent procoagulant activity to the apoptotic cell.	Phosphatidylserines	71-73	coagulation factor III, tissue factor	Homo sapiens	0-2
11312259-6	2001	Stern-Volmer analysis of the quenching of PT-(1-46)F4W in the presence and absence of 80% phosphatidylcholine/20% PS vesicles suggested that Trp-4 is positioned within the membrane and protected from aqueous quenching agents whereas Trp-41 remains solvent-accessible in the presence of PS-containing vesicles.	Phosphatidylserines	114-116	transient receptor potential cation channel subfamily C member 4	Homo sapiens	141-146
11389609-6	2001	P-Glycoprotein exhibited a broad specificity for phospholipids, and translocated phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin.	Phosphatidylserines	128-146	ATP binding cassette subfamily B member 1	Homo sapiens	0-14
11336647-8	2001	Liposomes of phosphatidylcholine, phosphatidylserine and their mixture increased secondary structure of 63-193 StAR at pH 7, as monitored by far-UV CD, and stable protein-liposome complexes were identified by gel-permeation chromatography.	Phosphatidylserines	34-52	steroidogenic acute regulatory protein	Homo sapiens	111-115
11309809-2	2001	Among the flow cytometric methods to measure apoptosis, the Annexin V assay that detects the membrane exposure of phosphatidylserine (PS) is one of the most commonly used.	Phosphatidylserines	114-132	annexin A5	Homo sapiens	60-69
11309809-2	2001	Among the flow cytometric methods to measure apoptosis, the Annexin V assay that detects the membrane exposure of phosphatidylserine (PS) is one of the most commonly used.	Phosphatidylserines	134-136	annexin A5	Homo sapiens	60-69
11309810-6	2001	PS external exposure was assessed after binding of FITC-conjugated annexin V as was the loss of membrane integrity after propidium iodide (PI) uptake.	Phosphatidylserines	0-2	annexin A5	Homo sapiens	67-76
11328609-2	2001	We tested the effects of Ca(2+) and myristoylation on the binding of calcineurin B alone or heterodimeric calcineurin to phosphatidylserine or phosphatidylcholine vesicles.	Phosphatidylserines	121-139	protein phosphatase 3 regulatory subunit B, alpha	Homo sapiens	69-82
11328609-6	2001	Calmodulin interfered with the association of calcineurin with phosphatidylserine.	Phosphatidylserines	63-81	calmodulin 1	Homo sapiens	0-10
11304418-5	2001	Release of phosphatidylserine (PS) and phosphatidic acid (PA) increased when platelets were treated with freezing/thawing, ionophore, and thrombin.	Phosphatidylserines	11-29	coagulation factor II, thrombin	Homo sapiens	138-146
11304418-5	2001	Release of phosphatidylserine (PS) and phosphatidic acid (PA) increased when platelets were treated with freezing/thawing, ionophore, and thrombin.	Phosphatidylserines	31-33	coagulation factor II, thrombin	Homo sapiens	138-146
11284717-11	2001	Anionic phospholipids, such as phosphatidic acid and phosphatidylserine, were absolutely required for activity of the purified enzyme, and their ability to activate GPAT was influenced by the purity of the GPAT preparation.	Phosphatidylserines	53-71	glycerol-3-phosphate acyltransferase, mitochondrial	Homo sapiens	165-169
11284717-11	2001	Anionic phospholipids, such as phosphatidic acid and phosphatidylserine, were absolutely required for activity of the purified enzyme, and their ability to activate GPAT was influenced by the purity of the GPAT preparation.	Phosphatidylserines	53-71	glycerol-3-phosphate acyltransferase, mitochondrial	Homo sapiens	206-210
11290771-4	2001	A new mAb to these CD99 epitopes, Ad20, induces programmed cell death of transformed T cells as determined by morphological changes, phosphatidylserine exposure on the cell surface, and uptake of propidium iodide.	Phosphatidylserines	133-151	CD99 molecule (Xg blood group)	Homo sapiens	19-23
11257039-4	2001	This modification allows RhoA to be attached to phosphatidyl serine on the inner leaflet of the plasma membrane.	Phosphatidylserines	48-67	ras homolog family member A	Homo sapiens	25-29
11084049-1	2001	In mammalian cells, phosphatidylserine is synthesized by two different enzymes, phosphatidylserine synthase (PSS)-1 and -2, via a base exchange reaction in which the head group of a phospholipid (phosphatidylcholine or phosphatidylethanolamine) is replaced by l-serine.	Phosphatidylserines	20-38	phosphatidylserine synthase 1	Homo sapiens	80-122
11118436-9	2001	The results of TLC overlay assay for the binding of (125)I-SVS VII to phospholipids and the interaction between SVS VII and phospholipid liposomes demonstrated a specific binding of this protein to both phosphatidylethanolamine and phosphatidylserine.	Phosphatidylserines	232-250	prostate and testis expressed 4	Mus musculus	59-66
11118436-9	2001	The results of TLC overlay assay for the binding of (125)I-SVS VII to phospholipids and the interaction between SVS VII and phospholipid liposomes demonstrated a specific binding of this protein to both phosphatidylethanolamine and phosphatidylserine.	Phosphatidylserines	232-250	prostate and testis expressed 4	Mus musculus	112-119
11307823-3	2001	Although the presence of PS is thought to be critical for thrombin generation at the platelet surface, no information is available about the effect of this differential PS exposure on the ability of adherent platelets to support thrombin generation.	Phosphatidylserines	25-27	coagulation factor II, thrombin	Homo sapiens	58-66
11342144-8	2001	Consistent with this observation, liposomes containing phosphatidylserine and cholesterol were aggregated by the tetrameric form of annexin 2 at submicromolar Ca(2+) concentrations.	Phosphatidylserines	55-73	annexin A2	Homo sapiens	132-141
11168945-3	2001	METHODS: Annexin V was used to determine whether phosphatidylserine (PS) exposure on the cell membrane surface plays a role in calcium oxalate monohydrate (COM) crystal attachment to cells that have lost their polarity as well as to cells that have lost their lipid asymmetry.	Phosphatidylserines	49-67	annexin A5	Homo sapiens	9-18
11133757-4	2001	Additionally, Lys2227, near Val2223, is part of a ring of positively charged residues that may contribute to electrostatic interaction of fVIII with negatively charged phosphatidylserine.	Phosphatidylserines	168-186	coagulation factor VIII	Homo sapiens	138-143
15256910-4	2001	However, the surface of apoptotic spermatozoa is characterised by externalisation of phosphatidylserine (PS), which has a high affinity to Annexin V.	Phosphatidylserines	85-103	annexin A5	Homo sapiens	139-148
21340828-6	2001	Exposure of PS can be detected in vitro and in vivo with fluorochrome- or biotin-labeled annexin V, a protein that binds to negatively charged phospholipids in the presence of calcium ions (6,7).	Phosphatidylserines	12-14	annexin A5	Homo sapiens	89-98
11090246-2	2000	In this study we followed the fate of PS-exposing platelets in the presence of antibodies purified from Systemic Lupus Erythematosus (SLE) and primary Anti-phospholipid Syndrome (APS) patients" sera by beta2GPI affinity chromatography.	Phosphatidylserines	38-40	apolipoprotein H	Homo sapiens	202-210
11090246-9	2000	Purified beta2GPI bound to PS-exposing platelets (association t(1/2): 250 min).	Phosphatidylserines	27-29	apolipoprotein H	Homo sapiens	9-17
11154118-11	2000	Amphoterin-binding protein components on the platelet surface were not identified, but amphoterin bound to phosphatidylserine and sulfatide in lipid binding assays.	Phosphatidylserines	107-125	high mobility group box 1	Homo sapiens	87-97
10956650-4	2000	In this study, we demonstrate that annexin II, V, or VI mediate Ca(2+) influx into phosphatidylserine (PS)-enriched liposomes, liposomes containing lipids extracted from authentic MV, and intact authentic MV.	Phosphatidylserines	83-101	annexin A2	Homo sapiens	35-45
10956650-4	2000	In this study, we demonstrate that annexin II, V, or VI mediate Ca(2+) influx into phosphatidylserine (PS)-enriched liposomes, liposomes containing lipids extracted from authentic MV, and intact authentic MV.	Phosphatidylserines	103-105	annexin A2	Homo sapiens	35-45
10903316-8	2000	Consistently, in vitro biomolecular interaction between PS/phosphatidylethanolamine /phosphatidylcholine liposomes, and Raf-1 increased in a PS concentration-dependent manner.	Phosphatidylserines	56-58	v-raf-leukemia viral oncogene 1	Mus musculus	120-125
10903316-8	2000	Consistently, in vitro biomolecular interaction between PS/phosphatidylethanolamine /phosphatidylcholine liposomes, and Raf-1 increased in a PS concentration-dependent manner.	Phosphatidylserines	141-143	v-raf-leukemia viral oncogene 1	Mus musculus	120-125
10903316-10	2000	Both the antiapoptotic effect of 22:6n-3 and Raf-1 translocation are sensitive to 22:6n-3 enrichment-induced PS accumulation, strongly suggesting that the protective effect of 22:6n-3 may be mediated at least in part through the promoted accumulation of PS in neuronal membranes.	Phosphatidylserines	109-111	v-raf-leukemia viral oncogene 1	Mus musculus	45-50
10903316-10	2000	Both the antiapoptotic effect of 22:6n-3 and Raf-1 translocation are sensitive to 22:6n-3 enrichment-induced PS accumulation, strongly suggesting that the protective effect of 22:6n-3 may be mediated at least in part through the promoted accumulation of PS in neuronal membranes.	Phosphatidylserines	254-256	v-raf-leukemia viral oncogene 1	Mus musculus	45-50
11082392-5	2000	Annexin V binds to phosphatidylserines, which are externalized to the outer membrane of apoptotic cells.	Phosphatidylserines	19-38	annexin A5	Rattus norvegicus	0-9
11053135-0	2000	PMP1 18-38, a yeast plasma membrane protein fragment, binds phosphatidylserine from bilayer mixtures with phosphatidylcholine: a (2)H-NMR study.	Phosphatidylserines	60-78	proteolipid ATPase	Saccharomyces cerevisiae S288C	0-4
11112862-1	2000	BACKGROUND: Loss of phospholipid asymmetry represents one of the hallmarks of apoptosis and results in the surface exposure of phosphatidylserine (PS) which can be indirectly monitored by the calcium-dependent binding of annexin V.	Phosphatidylserines	127-145	annexin A5	Homo sapiens	221-230
11112862-1	2000	BACKGROUND: Loss of phospholipid asymmetry represents one of the hallmarks of apoptosis and results in the surface exposure of phosphatidylserine (PS) which can be indirectly monitored by the calcium-dependent binding of annexin V.	Phosphatidylserines	147-149	annexin A5	Homo sapiens	221-230
11127271-3	2000	We hypothesised that, because of its affinity for phosphatidyl serine, apoH might bind to "flip flopped" cells and would therefore be useful as a marker for membrane flip flop in vivo.	Phosphatidylserines	50-69	apolipoprotein H	Homo sapiens	71-75
11052674-3	2000	Phospholipid vesicles composed of PE, phosphatidylserine (PS), and phosphatidylcholine support factor Xa generation.	Phosphatidylserines	38-56	coagulation factor X	Homo sapiens	95-104
11052674-3	2000	Phospholipid vesicles composed of PE, phosphatidylserine (PS), and phosphatidylcholine support factor Xa generation.	Phosphatidylserines	58-60	coagulation factor X	Homo sapiens	95-104
11003606-6	2000	SCP-2 also enhanced microsomal acyl-chain remodeling of phosphatidylethanolamine up to fivefold and phosphatidylserine twofold, depending on the specific fatty acyl-CoA, but had no effect on other phospholipid classes.	Phosphatidylserines	100-118	sterol carrier protein 2	Homo sapiens	0-5
11052698-0	2000	Conversion to docosahexaenoic acid-containing phosphatidylserine from squid skin lecithin by phospholipase D-mediated transphosphatidylation.	Phosphatidylserines	46-64	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	93-108
11052698-1	2000	Phospholipase D (PLD)-mediated transphosphatidylation of squid skin lecithin with L-serine was examined to prepare docosahexaenoic acid-containing phosphatidylserine (DHA-PS).	Phosphatidylserines	147-165	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
11052698-1	2000	Phospholipase D (PLD)-mediated transphosphatidylation of squid skin lecithin with L-serine was examined to prepare docosahexaenoic acid-containing phosphatidylserine (DHA-PS).	Phosphatidylserines	147-165	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
11004148-8	2000	In control mice, including those injected with annexin-V at the binding site of PS, no annexin-V-positive cells were observed.	Phosphatidylserines	80-82	annexin A5	Mus musculus	47-56
11018466-0	2000	Docosahexaenoic acid-deficient phosphatidyl serine and high alpha-tocopherol in a fetal mouse brain over-expressing Cu/Zn-superoxide dismutase.	Phosphatidylserines	31-50	superoxide dismutase 1, soluble	Mus musculus	116-142
10974061-10	2000	For example, 98;-99% precipitation of phosphatidylethanolamine, phosphatidylglycerol, and phosphatidylserine was achieved.Consequently, this new assay allows for a convenient examination of PLD activities toward a variety of phospholipid substrates, and in particular allows for the analysis of NAE formation from NAPE in vitro, a feature that will facilitate a more complete biochemical characterization of this anandamide-generating enzyme.	Phosphatidylserines	90-108	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	190-193
10770950-2	2000	We report here that protein kinase C (PKC) delta plays an important role in activated transbilayer movement of phospholipids and surface PS exposure by directly enhancing the activity of phospholipid scramblase.	Phosphatidylserines	137-139	protein kinase C delta	Homo sapiens	20-48
10748087-6	2000	Photoaffinity labeling demonstrated strong competition between atRA and phosphatidylserine (PS) for binding to PKCalpha, a slight competition with phorbol-12-myristate-13-acetate, and none with diacylglycerol, fatty acids, or Ca(2+).	Phosphatidylserines	72-90	protein kinase C alpha	Homo sapiens	111-119
10748087-6	2000	Photoaffinity labeling demonstrated strong competition between atRA and phosphatidylserine (PS) for binding to PKCalpha, a slight competition with phorbol-12-myristate-13-acetate, and none with diacylglycerol, fatty acids, or Ca(2+).	Phosphatidylserines	92-94	protein kinase C alpha	Homo sapiens	111-119
10748087-7	2000	At pharmacological concentrations (10 micrometer), atRA decreased PKCalpha activity through the competition with PS but not phorbol-12-myristate-13-acetate, diacylglycerol, or Ca(2+).	Phosphatidylserines	113-115	protein kinase C alpha	Homo sapiens	66-74
10899301-6	2000	The potential interactions between the anionic phospholipid phosphatidylserine and the redox-active cationic protein effector of apoptosis, cytochrome c, are presented as a potential mechanism to account for selective oxidation of phosphatidylserine during apoptosis.	Phosphatidylserines	60-78	cytochrome c, somatic	Homo sapiens	140-152
10921856-1	2000	We have investigated the binding of a new dansylcadaverine derivative of substance P (DNC-SP) with negatively charged small unilamellar vesicles composed of a mixture of phosphatidylcholine (PC) and either phosphatidylglycerol (PG) or phosphatidylserine (PS) using fluorescence spectroscopic techniques.	Phosphatidylserines	235-253	tachykinin precursor 1	Homo sapiens	73-84
10921856-1	2000	We have investigated the binding of a new dansylcadaverine derivative of substance P (DNC-SP) with negatively charged small unilamellar vesicles composed of a mixture of phosphatidylcholine (PC) and either phosphatidylglycerol (PG) or phosphatidylserine (PS) using fluorescence spectroscopic techniques.	Phosphatidylserines	255-257	tachykinin precursor 1	Homo sapiens	73-84
10889509-5	2000	Here, the PS-binding protein, annexin V, was used to show that in fact normal macrophages do express PS on their surface.	Phosphatidylserines	10-12	annexin A5	Homo sapiens	30-39
10933130-2	2000	The low bioavailability of subcutaneously administered factor VIII could have several causes: proteolytic degradation of the protein in the interstitium; adsorption to tissue, in particular to acidic phospholipids such as L-alpha phosphatidyl-L-serine (phosphatidylserine); the absence of free von Willebrand factor in the interstitium; phagocytosis by macrophages in the interstitium or in the lymph nodes; and coagulation could be initiated upon injection.	Phosphatidylserines	253-271	cytochrome c oxidase subunit 8A	Homo sapiens	62-66
10933130-10	2000	Both the von Willebrand factor and phosphatidylserine/phosphatidylcholine (PS/PC) liposomes showed a significant stabilising effect on VIII:C in the tissue homogenates.	Phosphatidylserines	35-53	surfactant protein C	Homo sapiens	75-80
10933130-10	2000	Both the von Willebrand factor and phosphatidylserine/phosphatidylcholine (PS/PC) liposomes showed a significant stabilising effect on VIII:C in the tissue homogenates.	Phosphatidylserines	35-53	cytochrome c oxidase subunit 8A	Homo sapiens	135-139
10933130-14	2000	Including phosphatidylserine in the formulations appeared to increase the availability, of subcutaneously administered r-VIII SQ in the pig.	Phosphatidylserines	10-28	cytochrome c oxidase subunit 8A	Homo sapiens	121-125
10914552-5	2000	In blast cells the DEVDases were activated and the caspase 3 was cleaved in relation to phosphatidyl serine exposure, showing a caspase-dependent pathway in anthracycline-induced apoptosis.	Phosphatidylserines	88-107	caspase 3	Homo sapiens	51-60
10941873-4	2000	L-FABP expression increased the masses of choline glycerophospholipids (ChoGpl) 1.5-fold, phosphatidylserine (PtdSer) 5.6-fold, ethanolamine glycerophospholipids 1.4-fold, sphingomyelin 1.7-fold, and phosphatidylinositol 2.6-fold.	Phosphatidylserines	90-108	fatty acid binding protein 1	Homo sapiens	0-6
11302338-7	2000	Binding of phosphatidylserine (PS) on apoptotic glioma cell membranes by annexin-V inhibited phagocytosis by 90% in both microglia and NHA.	Phosphatidylserines	11-29	annexin A5	Homo sapiens	73-82
10838184-2	2000	Thrombin, ionophore A23187 and the Ca(2+)-ATPase inhibitor 2, 5-di-tert-butyl-1,4-benzohydroquinone each induced a PS-dependent adhesion of Jurkat T cells.	Phosphatidylserines	115-117	coagulation factor II, thrombin	Homo sapiens	0-8
10838184-7	2000	However, after adhesion to thrombin-treated ECV304 cells for 10 min followed by detachment in 1 mM EDTA, there was a marked exposure of PS on the Jurkat cells.	Phosphatidylserines	136-138	coagulation factor II, thrombin	Homo sapiens	27-35
10838184-9	2000	Contact with thrombin-treated ECV304 cells thus induced the exposure of PS on Jurkat cells and, as Jurkat cells were unable to adhere to thrombin-treated ECV304 cells in the presence of EGTA, the adhesion of the two cell types may involve a Ca(2+) bridge between PS on both cell surfaces.	Phosphatidylserines	72-74	coagulation factor II, thrombin	Homo sapiens	13-21
10838184-11	2000	However, findings made with several T cell lines were generally, but not completely, consistent with the possibility that adhesion to surface PS on endothelial cells may be a feature of T cells that express both CD4(+) and CD8(+) antigens.	Phosphatidylserines	142-144	CD4 molecule	Homo sapiens	212-215
10838184-11	2000	However, findings made with several T cell lines were generally, but not completely, consistent with the possibility that adhesion to surface PS on endothelial cells may be a feature of T cells that express both CD4(+) and CD8(+) antigens.	Phosphatidylserines	142-144	CD8a molecule	Homo sapiens	223-226
10827979-6	2000	The data suggest that the lipid phosphate groups of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS) in PC/PE/PS (4:4:1, mol/mol) are primary targets for Ca(2+).	Phosphatidylserines	113-131	procollagen C-endopeptidase enhancer	Homo sapiens	140-148
10827979-6	2000	The data suggest that the lipid phosphate groups of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS) in PC/PE/PS (4:4:1, mol/mol) are primary targets for Ca(2+).	Phosphatidylserines	133-135	procollagen C-endopeptidase enhancer	Homo sapiens	140-148
10821695-2	2000	Bovine lactadherin binds to alpha(v)beta(5) integrin in an RGD-dependent manner and also to phospholipids, especially phosphatidyl serine.	Phosphatidylserines	118-137	LOC787514	Bos taurus	7-18
10821695-8	2000	Both fragments bound to phosphatidyl serine in a concentration-dependent manner with an affinity similar to native lactadherin (K(d) = 1.8 nM).	Phosphatidylserines	24-43	LOC787514	Bos taurus	115-126
10801341-6	2000	We observed also a clear selectivity of (3,4,5)PIP3 over (4,5)PIP2 for stimulating the activity of ARNO on ARF with vesicles containing 10% PS and 1% PIP2 or PIP3.	Phosphatidylserines	140-142	cytohesin 2	Homo sapiens	99-103
10865135-1	2000	Stimulation of the aminophospholipid translocase, responsible for the transport of phosphatidylserine and phosphatidylethanolamine from the outer to the inner leaflet of the plasma membrane, provokes endocytic-like vesicles in erythrocytes and stimulates endocytosis in K562 cells.	Phosphatidylserines	83-101	ATPase phospholipid transporting 8A1	Homo sapiens	19-48
10792381-6	2000	B cells with PS exposure in vivo might provide a site for coagulation and inflammation, and so contribute to the pathogenesis of HAM/TSP and its complications.	Phosphatidylserines	13-15	thrombospondin 1	Homo sapiens	133-136
10754513-3	2000	Phosphatidylserine (PS) redistribution from the inner plasma membrane leaflet to the outer leaflet, an early event in PCD, can be detected by annexin V (AxV) binding to PS.	Phosphatidylserines	0-18	annexin A5	Homo sapiens	142-151
10754513-3	2000	Phosphatidylserine (PS) redistribution from the inner plasma membrane leaflet to the outer leaflet, an early event in PCD, can be detected by annexin V (AxV) binding to PS.	Phosphatidylserines	20-22	annexin A5	Homo sapiens	142-151
10754513-3	2000	Phosphatidylserine (PS) redistribution from the inner plasma membrane leaflet to the outer leaflet, an early event in PCD, can be detected by annexin V (AxV) binding to PS.	Phosphatidylserines	169-171	annexin A5	Homo sapiens	142-151
10738279-3	2000	METHODS: Experimentally determined CFDs for VP-16 (etoposide)-induced apoptosis were measured by phosphotidylserine surface expression and mitochondrial membrane potential dissipation (DeltaPsi(m)) in BV173 leukemia cells.	Phosphatidylserines	97-115	host cell factor C1	Homo sapiens	44-49
10731712-0	2000	Promotion of the uptake of PS liposomes and apoptotic cells by a product of growth arrest-specific gene, gas6.	Phosphatidylserines	27-29	growth arrest specific 6	Homo sapiens	105-109
10731712-3	2000	In our previous study, we demonstrated that Gas6 specifically binds to phosphatidylserine (PS) and links Axl-expressing cells to the PS-coated surface.	Phosphatidylserines	71-89	growth arrest specific 6	Homo sapiens	44-48
10731712-3	2000	In our previous study, we demonstrated that Gas6 specifically binds to phosphatidylserine (PS) and links Axl-expressing cells to the PS-coated surface.	Phosphatidylserines	91-93	growth arrest specific 6	Homo sapiens	44-48
10731712-3	2000	In our previous study, we demonstrated that Gas6 specifically binds to phosphatidylserine (PS) and links Axl-expressing cells to the PS-coated surface.	Phosphatidylserines	133-135	growth arrest specific 6	Homo sapiens	44-48
10731712-3	2000	In our previous study, we demonstrated that Gas6 specifically binds to phosphatidylserine (PS) and links Axl-expressing cells to the PS-coated surface.	Phosphatidylserines	133-135	AXL receptor tyrosine kinase	Homo sapiens	105-108
10731712-4	2000	In this study, to further understand the biological role of the interaction of Gas6 with PS, we examined the effect of Gas6 on the uptake of PS liposomes by macrophages.	Phosphatidylserines	141-143	growth arrest specific 6	Homo sapiens	119-123
10731712-5	2000	In vitro phagocytosis studies showed that Gas6 enhanced the uptake of PS liposomes approximately threefold and that the interaction of Gas6 with the surface of macrophages was essential for this enhancement.	Phosphatidylserines	70-72	growth arrest specific 6	Homo sapiens	42-46
10731712-6	2000	Analyses of the mechanism of the uptake of PS liposome suggested that Gas6 interacts with PS liposome via its N-terminal Gla domain and with macrophages via its C-terminal domain.	Phosphatidylserines	43-45	growth arrest specific 6	Homo sapiens	70-74
10731712-6	2000	Analyses of the mechanism of the uptake of PS liposome suggested that Gas6 interacts with PS liposome via its N-terminal Gla domain and with macrophages via its C-terminal domain.	Phosphatidylserines	90-92	growth arrest specific 6	Homo sapiens	70-74
10731712-7	2000	Like that of PS liposomes, the uptake of apoptotic cells by macrophages was also enhanced, approximately twofold, in the presence of Gas6.	Phosphatidylserines	13-15	growth arrest specific 6	Homo sapiens	133-137
10684648-4	2000	We used ellipsometry to study the binding of annexin V and of complexes of beta(2)GPI with patient-derived IgG antibodies to beta(2)GPI, commonly referred to as anticardiolipin antibodies (ACA), to phospholipid bilayers composed of phosphatidylcholine (PC) and 20% phosphatidylserine (PS).	Phosphatidylserines	265-283	apolipoprotein H	Homo sapiens	75-85
10684648-4	2000	We used ellipsometry to study the binding of annexin V and of complexes of beta(2)GPI with patient-derived IgG antibodies to beta(2)GPI, commonly referred to as anticardiolipin antibodies (ACA), to phospholipid bilayers composed of phosphatidylcholine (PC) and 20% phosphatidylserine (PS).	Phosphatidylserines	285-287	apolipoprotein H	Homo sapiens	75-85
10666202-8	2000	PS-exposing RBCs and PS-containing lipid vesicles adhered to immobilized thrombospondin (TSP) and matrix TSP, respectively, and adherence of PS-exposing RBCs to EC monolayers was reduced by antibodies to TSP and to its EC receptor, alpha(v)beta(3).	Phosphatidylserines	0-2	thrombospondin 1	Homo sapiens	73-87
10666202-8	2000	PS-exposing RBCs and PS-containing lipid vesicles adhered to immobilized thrombospondin (TSP) and matrix TSP, respectively, and adherence of PS-exposing RBCs to EC monolayers was reduced by antibodies to TSP and to its EC receptor, alpha(v)beta(3).	Phosphatidylserines	0-2	thrombospondin 1	Homo sapiens	89-92
10666202-8	2000	PS-exposing RBCs and PS-containing lipid vesicles adhered to immobilized thrombospondin (TSP) and matrix TSP, respectively, and adherence of PS-exposing RBCs to EC monolayers was reduced by antibodies to TSP and to its EC receptor, alpha(v)beta(3).	Phosphatidylserines	0-2	thrombospondin 1	Homo sapiens	105-108
10666202-8	2000	PS-exposing RBCs and PS-containing lipid vesicles adhered to immobilized thrombospondin (TSP) and matrix TSP, respectively, and adherence of PS-exposing RBCs to EC monolayers was reduced by antibodies to TSP and to its EC receptor, alpha(v)beta(3).	Phosphatidylserines	0-2	thrombospondin 1	Homo sapiens	105-108
10666202-9	2000	Together, these results indicate a role for PS and matrix TSP in the adherence of PS-exposing RBCs to EC monolayers, and suggest an important contribution of PS-exposing RBCs in pathologies with reported vascular damage, such as sickle cell anemia.	Phosphatidylserines	82-84	thrombospondin 1	Homo sapiens	58-61
10666202-9	2000	Together, these results indicate a role for PS and matrix TSP in the adherence of PS-exposing RBCs to EC monolayers, and suggest an important contribution of PS-exposing RBCs in pathologies with reported vascular damage, such as sickle cell anemia.	Phosphatidylserines	82-84	thrombospondin 1	Homo sapiens	58-61
10652232-7	2000	Membrane phospholipids such as phosphatidylserine (PS) or phosphatidylinositol (PtdIns) are thought to serve as the ligands for CD14 in apoptotic cells.	Phosphatidylserines	31-49	CD14 molecule	Homo sapiens	128-132
10652232-7	2000	Membrane phospholipids such as phosphatidylserine (PS) or phosphatidylinositol (PtdIns) are thought to serve as the ligands for CD14 in apoptotic cells.	Phosphatidylserines	51-53	CD14 molecule	Homo sapiens	128-132
10675299-3	2000	Here, the interactions of an anionic phosphatidylserine/monosialoganglioside-G(M1) (4:1, w:w) lipid monolayer with 18.5-kDa MBP preparations from age-matched adult humans without MS (no Cit residues), with chronic MS (6 Cit), and with acute Marburg-type MS (18 Cit) were studied by transmission and ultralow dose scanning transmission electron microscopy under cryogenic conditions.	Phosphatidylserines	37-55	myelin basic protein	Homo sapiens	124-127
10739387-1	2000	Phosphatidylserine (PhtdSer) is an anionic aminophospholipid necessary for the development of optimal tissue factor (TF) activity at the cell surface.	Phosphatidylserines	0-18	coagulation factor III, tissue factor	Homo sapiens	102-115
10739387-1	2000	Phosphatidylserine (PhtdSer) is an anionic aminophospholipid necessary for the development of optimal tissue factor (TF) activity at the cell surface.	Phosphatidylserines	0-18	coagulation factor III, tissue factor	Homo sapiens	117-119
10612714-7	2000	The ratio hydrolysis without apo C II/hydrolysis with apo CII was different when other phospholipids than myrystoyl-phospatidylcholine were assayed: phosphatidyl-serine, ethanolamine, -choline, -glycerol, or diglycerides and butanoylglycerols.	Phosphatidylserines	149-168	apolipoprotein C2	Bos taurus	54-61
10630925-8	2000	Mitochondria-associated membranes (MAM) are the major site of PS synthesis.	Phosphatidylserines	62-64	sarcoglycan gamma	Homo sapiens	35-38
10630925-16	2000	Respiratory mitochondrial activity modulated the association of MAM and mitochondria, triggering a mechanism that allowed the transport of PS across the outer mitochondrial membrane.	Phosphatidylserines	139-141	sarcoglycan gamma	Homo sapiens	64-67
10705462-1	2000	Saccharomyces cerevisiae cho1/pss mutants, which are severely impaired in phosphatidylserine (PS) synthesis, do not have detectable amounts of PS in their lipid fractions.	Phosphatidylserines	74-92	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	25-29
10705462-1	2000	Saccharomyces cerevisiae cho1/pss mutants, which are severely impaired in phosphatidylserine (PS) synthesis, do not have detectable amounts of PS in their lipid fractions.	Phosphatidylserines	94-96	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	25-29
17030343-2	1999	The protein 4.1-phosphatidyl serine (PS) interactions served as the model system to demonstrate the membrane lipid-protein interactions.	Phosphatidylserines	16-35	erythrocyte membrane protein band 4.1	Homo sapiens	4-15
10647965-4	1999	RESULTS: In elderly subjects, a higher proportion of lymphocytes had specific annexin V binding to phosphatidylserine (PS) than in young subjects (young: median percentage of cells with specific annexin V binding to PS 5.3 [second to fourth quintiles range 3.8-8.7]; elderly: 8.5 [5.2-17.2]; p = .028).	Phosphatidylserines	99-117	annexin A5	Homo sapiens	78-87
10647965-4	1999	RESULTS: In elderly subjects, a higher proportion of lymphocytes had specific annexin V binding to phosphatidylserine (PS) than in young subjects (young: median percentage of cells with specific annexin V binding to PS 5.3 [second to fourth quintiles range 3.8-8.7]; elderly: 8.5 [5.2-17.2]; p = .028).	Phosphatidylserines	119-121	annexin A5	Homo sapiens	78-87
10533050-8	1999	There were, however, changes in the fatty acid composition of PE and phosphatidylserine (PS), which resulted in a lower ratio of polyunsaturated to saturated fatty acids in PE and in a higher ratio in apoE-deficient mice compared to the corresponding control values.	Phosphatidylserines	69-87	apolipoprotein E	Mus musculus	201-205
10533050-8	1999	There were, however, changes in the fatty acid composition of PE and phosphatidylserine (PS), which resulted in a lower ratio of polyunsaturated to saturated fatty acids in PE and in a higher ratio in apoE-deficient mice compared to the corresponding control values.	Phosphatidylserines	89-91	apolipoprotein E	Mus musculus	201-205
11015572-1	1999	The aminophospholipid translocase transports phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another.	Phosphatidylserines	45-63	ATPase, class I, type 8B, member 1	Mus musculus	4-33
19003151-2	1999	Using fluorescently labelled annexin V, which preferentially binds phosphatidylserine (PS) in the presence of Ca(2+), the externalization of PS can be measured and apoptosis quantified using flow cytometry.	Phosphatidylserines	67-85	annexin A5	Homo sapiens	29-38
19003151-2	1999	Using fluorescently labelled annexin V, which preferentially binds phosphatidylserine (PS) in the presence of Ca(2+), the externalization of PS can be measured and apoptosis quantified using flow cytometry.	Phosphatidylserines	87-89	annexin A5	Homo sapiens	29-38
19003151-7	1999	The signal detected is a direct consequence of the binding of annexin V to externalized PS on apoptotic cells and the proximity of the label to the base of the plate.	Phosphatidylserines	88-90	annexin A5	Homo sapiens	62-71
10580574-0	1999	Involvement of phosphatidylserine and non-phospholipid components of the hepatitis B virus envelope in human Annexin V binding and in HBV infection in vitro.	Phosphatidylserines	15-33	annexin A5	Homo sapiens	109-118
10654293-8	1999	Phosphorus NMR spectroscopy shows that phosphatidylcholine, phosphatidylinositol, sphingomyelin, and phosphatidylserine increase steadily from F15 to P21.	Phosphatidylserines	101-119	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	150-153
10744422-2	1999	In order to measure PS exposure in blood cells, we developed a flow-cytometric procedure to measure annexin V binding to leukocytes and platelets in whole-blood samples.	Phosphatidylserines	20-22	annexin A5	Homo sapiens	100-109
10497163-10	1999	In vitro, Plb3p hydrolyzes only phosphatidylinositol and phosphatidylserine and, to a lesser extent, their lyso-analogs.	Phosphatidylserines	57-75	lysophospholipase	Saccharomyces cerevisiae S288C	10-15
10497177-4	1999	FXa generation at a rotating disc coated with TF embedded in a membrane composed of pure phosphatidylcholine (TF.PC) or 25% phosphatidylserine and 75% phosphatidylcholine (TF.PSPC) was measured in the presence of preformed complexes of FXa.TFPI(FL) or FXa.TFPI(1-161) (TFPI lacking the third Kunitz domain and C terminus).	Phosphatidylserines	124-142	coagulation factor X	Homo sapiens	0-3
10544921-6	1999	PS exposure was determined by flow cytometry after labeling the cells with FITC-conjugated annexin V.	Phosphatidylserines	0-2	annexin A5	Homo sapiens	91-100
10500152-4	1999	Exposure of phosphatidylserine and phosphatidylethanolamine on platelets, as determined by an increase in annexin V binding, was strongly stimulated by SFLLRN, thrombin, and collagen, but only to a minor extent by GYPGQV.	Phosphatidylserines	12-30	annexin A5	Homo sapiens	106-115
10500152-4	1999	Exposure of phosphatidylserine and phosphatidylethanolamine on platelets, as determined by an increase in annexin V binding, was strongly stimulated by SFLLRN, thrombin, and collagen, but only to a minor extent by GYPGQV.	Phosphatidylserines	12-30	coagulation factor II, thrombin	Homo sapiens	160-168
10504221-4	1999	Deuterium NMR in membranes containing phosphatidylcholine (PC) and phosphatidylserine (PS) indicates that this peptide, MARCKS(151-175), partially penetrates the membrane interface when bound and alters the effective charge density on the membrane interface by approximately 2 charges per bound peptide.	Phosphatidylserines	67-85	myristoylated alanine rich protein kinase C substrate	Homo sapiens	120-126
10504221-4	1999	Deuterium NMR in membranes containing phosphatidylcholine (PC) and phosphatidylserine (PS) indicates that this peptide, MARCKS(151-175), partially penetrates the membrane interface when bound and alters the effective charge density on the membrane interface by approximately 2 charges per bound peptide.	Phosphatidylserines	87-89	myristoylated alanine rich protein kinase C substrate	Homo sapiens	120-126
10527410-3	1999	Binding to 100% PS was saturable (apparent Kd=5 microM, Bmax=1.9 g protein/g lipid), reversible, and involved a minor subfraction of the fibrinogen preparation (3-6% of total protein).	Phosphatidylserines	16-18	fibrinogen beta chain	Homo sapiens	137-147
10527410-10	1999	Further study of the PS binding activity of fibrinogen may lead to new insights about fibrinogen function.	Phosphatidylserines	21-23	fibrinogen beta chain	Homo sapiens	44-54
10527410-10	1999	Further study of the PS binding activity of fibrinogen may lead to new insights about fibrinogen function.	Phosphatidylserines	21-23	fibrinogen beta chain	Homo sapiens	86-96
10548149-9	1999	An endogenous human protein, annexin V, has a high affinity (kd = 7 nmol/L) for PS bound to the cell membrane.	Phosphatidylserines	80-82	annexin A5	Homo sapiens	29-38
10452909-0	1999	Annexin V inhibits phosphatidylserine-induced intrauterine growth restriction in mice.	Phosphatidylserines	19-37	annexin A5	Mus musculus	0-9
10438567-4	1999	These cells can be recognized by staining with Annexin V, which binds to phosphatidylserine with high affinity.	Phosphatidylserines	73-91	annexin A5	Homo sapiens	47-56
10432300-1	1999	Phosphatidylserine (PtdSer) is synthesized in mammalian cells by two base-exchange enzymes: PtdSer synthase (PSS)-1 primarily uses phosphatidylcholine as a substrate for exchange with serine, whereas PSS2 uses phosphatidylethanolamine (PtdEtn).	Phosphatidylserines	0-18	phosphatidylserine synthase 1	Homo sapiens	92-115
10432300-1	1999	Phosphatidylserine (PtdSer) is synthesized in mammalian cells by two base-exchange enzymes: PtdSer synthase (PSS)-1 primarily uses phosphatidylcholine as a substrate for exchange with serine, whereas PSS2 uses phosphatidylethanolamine (PtdEtn).	Phosphatidylserines	0-18	phosphatidylserine synthase 2	Homo sapiens	200-204
10691296-6	1999	Activation of the IgE pathway by MAM and concanavalin A (Con A) in the presence of phosphatidylserine led to dose-dependent histamine release in normal rats, and a 10-25% lower level of induction was observed in EAE rats.	Phosphatidylserines	83-101	alpha-2-macroglobulin	Rattus norvegicus	33-36
10497893-0	1999	Mutational analysis of Raf-1 cysteine rich domain: requirement for a cluster of basic aminoacids for interaction with phosphatidylserine.	Phosphatidylserines	118-136	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	23-28
10497893-5	1999	In the present study, we have investigated the consequences of progressive deletions and point mutations within the cysteine-rich domain of Raf-1 on its ability to bind PS.	Phosphatidylserines	169-171	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	140-145
10497893-6	1999	A reduced interaction with PS was observed in vitro for all deletion mutants of Raf-1 expressed either as full-length proteins or as fragments containing the isolated cysteine-rich domain.	Phosphatidylserines	27-29	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	80-85
10497893-8	1999	Expression of Raf-1 in vivo, containing point mutations in the cysteine-rich domain resulted in a truncated polypeptide that lacked both the Ras and PS binding sites and could no longer translocate to the plasma membrane upon serum stimulation.	Phosphatidylserines	149-151	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	14-19
10419523-2	1999	The rate of PLCdelta1 hydrolysis of phosphatidylinositol 4,5-bisphosphate was stimulated 20-fold by phosphatidylserine (PS), 4-fold by phosphatidic acid (PA), and not at all by phosphatidylethanolamine or phosphatidylcholine (PC).	Phosphatidylserines	100-118	phospholipase C delta 1	Homo sapiens	12-21
10419523-2	1999	The rate of PLCdelta1 hydrolysis of phosphatidylinositol 4,5-bisphosphate was stimulated 20-fold by phosphatidylserine (PS), 4-fold by phosphatidic acid (PA), and not at all by phosphatidylethanolamine or phosphatidylcholine (PC).	Phosphatidylserines	100-118	surfactant protein C	Homo sapiens	120-122
10395936-3	1999	A 15-min pre-treatment with polymyxin B (PMXB), a protein kinase C (PKC) inhibitor acting at the phosphatidylserine (PS) binding site, suppressed PDBu stimulatory effects on free calcium entry and fluid resorption but not on phosphatidylinositol 4, 5-bisphosphate (PtdIns-4,5-P2) breakdown.	Phosphatidylserines	97-115	proline rich transmembrane protein 2	Homo sapiens	50-66
10395936-3	1999	A 15-min pre-treatment with polymyxin B (PMXB), a protein kinase C (PKC) inhibitor acting at the phosphatidylserine (PS) binding site, suppressed PDBu stimulatory effects on free calcium entry and fluid resorption but not on phosphatidylinositol 4, 5-bisphosphate (PtdIns-4,5-P2) breakdown.	Phosphatidylserines	97-115	proline rich transmembrane protein 2	Homo sapiens	68-71
10395936-3	1999	A 15-min pre-treatment with polymyxin B (PMXB), a protein kinase C (PKC) inhibitor acting at the phosphatidylserine (PS) binding site, suppressed PDBu stimulatory effects on free calcium entry and fluid resorption but not on phosphatidylinositol 4, 5-bisphosphate (PtdIns-4,5-P2) breakdown.	Phosphatidylserines	117-119	proline rich transmembrane protein 2	Homo sapiens	50-66
10395936-3	1999	A 15-min pre-treatment with polymyxin B (PMXB), a protein kinase C (PKC) inhibitor acting at the phosphatidylserine (PS) binding site, suppressed PDBu stimulatory effects on free calcium entry and fluid resorption but not on phosphatidylinositol 4, 5-bisphosphate (PtdIns-4,5-P2) breakdown.	Phosphatidylserines	117-119	proline rich transmembrane protein 2	Homo sapiens	68-71
10444191-5	1999	This enhancement of factor Xa-dependent prothrombinase activity of complement-activated RBC was inhibited by the treatment of the RBC with annexin V, a protein with binding affinity for anionic phospholipids especially for phosphatidylserine (PS).	Phosphatidylserines	223-241	coagulation factor X	Homo sapiens	20-29
10444191-5	1999	This enhancement of factor Xa-dependent prothrombinase activity of complement-activated RBC was inhibited by the treatment of the RBC with annexin V, a protein with binding affinity for anionic phospholipids especially for phosphatidylserine (PS).	Phosphatidylserines	223-241	annexin A5	Homo sapiens	139-148
10444191-5	1999	This enhancement of factor Xa-dependent prothrombinase activity of complement-activated RBC was inhibited by the treatment of the RBC with annexin V, a protein with binding affinity for anionic phospholipids especially for phosphatidylserine (PS).	Phosphatidylserines	243-245	coagulation factor X	Homo sapiens	20-29
10444191-5	1999	This enhancement of factor Xa-dependent prothrombinase activity of complement-activated RBC was inhibited by the treatment of the RBC with annexin V, a protein with binding affinity for anionic phospholipids especially for phosphatidylserine (PS).	Phosphatidylserines	243-245	annexin A5	Homo sapiens	139-148
10453073-1	1999	Phosphatidylserine (PS) exposure on propidium iodide negative cells using FITC labelled annexin-V has been used to quantify apoptosis in vitro and in vivo.	Phosphatidylserines	0-18	annexin A5	Homo sapiens	88-97
10453073-1	1999	Phosphatidylserine (PS) exposure on propidium iodide negative cells using FITC labelled annexin-V has been used to quantify apoptosis in vitro and in vivo.	Phosphatidylserines	20-22	annexin A5	Homo sapiens	88-97
10453073-2	1999	Detection of PS within cells undergoing necrosis is also possible if labelled annexin-V specific for PS enters the cell following early membrane damage.	Phosphatidylserines	13-15	annexin A5	Homo sapiens	78-87
10453073-2	1999	Detection of PS within cells undergoing necrosis is also possible if labelled annexin-V specific for PS enters the cell following early membrane damage.	Phosphatidylserines	101-103	annexin A5	Homo sapiens	78-87
10411684-7	1999	"Flip flop" was gauged by preferential decrements in phosphatidylserine (PS) versus phosphatidylcholine (PC; PS/PC ratios) in response to extracellular (Naja) PLA2 exposure.	Phosphatidylserines	53-71	phospholipase A2, group IB, pancreas	Mus musculus	159-163
10411684-7	1999	"Flip flop" was gauged by preferential decrements in phosphatidylserine (PS) versus phosphatidylcholine (PC; PS/PC ratios) in response to extracellular (Naja) PLA2 exposure.	Phosphatidylserines	73-75	phospholipase A2, group IB, pancreas	Mus musculus	159-163
10445849-0	1999	Interactions of c-Raf-1 with phosphatidylserine and 14-3-3.	Phosphatidylserines	29-47	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	18-23
10445849-4	1999	Incubation of Raf-1 with phosphatidylserine, an inner plasma membrane phospholipid, results in removal of 14-3-3 and an increase in Raf-1 kinase activity, whereas removal of 14-3-3 from Raf-1 using specific phosphopeptides substantially reduces Raf-1 basal kinase activity.	Phosphatidylserines	25-43	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	14-19
10445849-4	1999	Incubation of Raf-1 with phosphatidylserine, an inner plasma membrane phospholipid, results in removal of 14-3-3 and an increase in Raf-1 kinase activity, whereas removal of 14-3-3 from Raf-1 using specific phosphopeptides substantially reduces Raf-1 basal kinase activity.	Phosphatidylserines	25-43	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	132-137
10445849-4	1999	Incubation of Raf-1 with phosphatidylserine, an inner plasma membrane phospholipid, results in removal of 14-3-3 and an increase in Raf-1 kinase activity, whereas removal of 14-3-3 from Raf-1 using specific phosphopeptides substantially reduces Raf-1 basal kinase activity.	Phosphatidylserines	25-43	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	132-137
10445849-4	1999	Incubation of Raf-1 with phosphatidylserine, an inner plasma membrane phospholipid, results in removal of 14-3-3 and an increase in Raf-1 kinase activity, whereas removal of 14-3-3 from Raf-1 using specific phosphopeptides substantially reduces Raf-1 basal kinase activity.	Phosphatidylserines	25-43	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	132-137
10540966-7	1999	Treatment of PHX-exposed erythrocyte with bee venom phospholipase A2 induces the translocation of phosphatidylserine (PS) and phosphatidylethanolamine (PE) to the outer surface of the cell membrane.	Phosphatidylserines	98-116	phospholipase A2 group IB	Homo sapiens	52-68
10540966-7	1999	Treatment of PHX-exposed erythrocyte with bee venom phospholipase A2 induces the translocation of phosphatidylserine (PS) and phosphatidylethanolamine (PE) to the outer surface of the cell membrane.	Phosphatidylserines	118-120	phospholipase A2 group IB	Homo sapiens	52-68
10208993-3	1999	Incubation with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA; 10(-7) M) was associated with a transient induction in both cell fractions of calcium/phosphatidylserine-dependent PKC activity, which was elevated from 15 min to 1 h. Consistent with this, mRNAs for the calcium/phospholipid-dependent isomeric forms of PKC (alpha, beta, and gamma) were detected.	Phosphatidylserines	163-181	protein kinase C, alpha	Rattus norvegicus	192-195
10208993-3	1999	Incubation with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA; 10(-7) M) was associated with a transient induction in both cell fractions of calcium/phosphatidylserine-dependent PKC activity, which was elevated from 15 min to 1 h. Consistent with this, mRNAs for the calcium/phospholipid-dependent isomeric forms of PKC (alpha, beta, and gamma) were detected.	Phosphatidylserines	163-181	protein kinase C, alpha	Rattus norvegicus	330-357
10233092-3	1999	Quantitative validation was obtained by use of annexin V, a protein with high binding affinity for phosphatidylserine-containing phospholipid membranes, resulting in a transport-limited adsorption rate.	Phosphatidylserines	99-117	annexin A5	Homo sapiens	47-56
10222260-2	1999	It has been shown previously that annexin V is one of the most sensitive tools with which the presence of small amounts of PS on the outer surface of eukaryotic cells can be detected.	Phosphatidylserines	123-125	annexin A5	Homo sapiens	34-43
10353318-4	1999	The sialidase-treated LPL also showed similar hydrolyzing activity for triolein emulsified with Triton X-100, phosphatidylcholine and phosphatidylethanolamine, whereas it showed significantly increased hydrolyzing activity for triolein emulsified with phosphatidylserine and cardiolipin (152% and 183%, compared with untreated LPL, respectively).	Phosphatidylserines	252-270	lipoprotein lipase	Homo sapiens	22-25
10026214-7	1999	Overexpression of the rat SR-BI cDNA increased the PS-mediated phagocytic activity of Sertoli cell-derived cell lines.	Phosphatidylserines	51-53	scavenger receptor class B, member 1	Rattus norvegicus	26-31
10026214-9	1999	Finally, the addition of high density lipoprotein, a ligand specific for SR-BI, decreased both phagocytosis of spermatogenic cells and incorporation of PS-containing liposomes by Sertoli cells.	Phosphatidylserines	152-154	scavenger receptor class B, member 1	Rattus norvegicus	73-78
10200565-4	1999	Similarly, annexin V was able to inhibit phagocytosis of lipid-symmetric erythrocytes, another target cell upon which PS is exposed.	Phosphatidylserines	118-120	annexin A5	Mus musculus	11-20
9914152-1	1999	When human platelets are stimulated with collagen or thrombin, the asymmetric distribution of membrane lipids is disrupted as phosphatidylserine and phosphatidylethanolamine translocate from the inner monolayer to the outer monolayer.	Phosphatidylserines	126-144	coagulation factor II, thrombin	Homo sapiens	53-61
9894014-8	1999	Collectively, these results demonstrate that an aldehyde generated by the myeloperoxidase system of phagocytes can covalently modify the amino groups of phosphatidylethanolamine and phosphatidylserine.	Phosphatidylserines	182-200	myeloperoxidase	Homo sapiens	74-89
9841900-5	1999	In those cells, the phosphatidylserine analogue became rapidly enriched on the cytoplasmic leaflet by the activity of a putative aminophospholipid translocase similar to intact cells of fresh, ejaculated samples.	Phosphatidylserines	20-38	ATPase phospholipid transporting 8A1	Homo sapiens	129-158
10406552-4	1999	METHODS: Cell apoptosis is measured by flow cytometry (FCM) to detect phosphatidylserine (PS) exposure on early apoptotic cells using fluorescein-labeled annexin V.	Phosphatidylserines	70-88	annexin A5	Homo sapiens	154-163
9894786-2	1998	Based on their annexin V-affinity, resulting from phosphatidylserine (PS) exposure at the outer leaflet of the plasma membrane, apoptotic cells can be distinguished from annexin V-negative living cells, by using microscopic and flow cytometric procedures.	Phosphatidylserines	50-68	annexin A5	Homo sapiens	15-24
9894786-2	1998	Based on their annexin V-affinity, resulting from phosphatidylserine (PS) exposure at the outer leaflet of the plasma membrane, apoptotic cells can be distinguished from annexin V-negative living cells, by using microscopic and flow cytometric procedures.	Phosphatidylserines	70-72	annexin A5	Homo sapiens	15-24
9858696-3	1998	Here, we report the investigation of PLP"s putative adhesive function using purified PLP and reconstituted phospholipid vesicles made of either 100% phosphatidylcholine (PC), or a mixture of 92% PC and 8% phosphatidylserine (PS), by weight.	Phosphatidylserines	205-223	proteolipid protein 1	Homo sapiens	37-40
9858696-3	1998	Here, we report the investigation of PLP"s putative adhesive function using purified PLP and reconstituted phospholipid vesicles made of either 100% phosphatidylcholine (PC), or a mixture of 92% PC and 8% phosphatidylserine (PS), by weight.	Phosphatidylserines	225-227	proteolipid protein 1	Homo sapiens	37-40
9845435-1	1998	Annexin V belongs to the family of calcium-dependent phospholipid binding proteins and binds almost solely to phosphatidylserine (PS).	Phosphatidylserines	110-128	annexin A5	Homo sapiens	0-9
9845435-1	1998	Annexin V belongs to the family of calcium-dependent phospholipid binding proteins and binds almost solely to phosphatidylserine (PS).	Phosphatidylserines	130-132	annexin A5	Homo sapiens	0-9
9845435-8	1998	Annexin V binding was found to increase rapidly, with increasing PS concentrations up to a certain level (attained at 6 mol% PS).	Phosphatidylserines	65-67	annexin A5	Homo sapiens	0-9
9845435-9	1998	Further increase of the PS concentration resulted only in a slight increase of annexin V binding.	Phosphatidylserines	24-26	annexin A5	Homo sapiens	79-88
10100734-2	1998	This method is based on the Ca2+-dependent binding of annexin V to phosphatidylserine, a negatively charged phospholipid, located at the inner leaflet of the cell membrane in living cells.	Phosphatidylserines	67-85	annexin A5	Gallus gallus	54-63
9834113-9	1998	Anti-CD36 blocked uptake into unstimulated or stimulated macrophages, suggesting CD36 involvement not only with the alpha(v)beta3 integrin mechanism (as previously reported) but also with PS recognition.	Phosphatidylserines	188-190	CD36 molecule	Homo sapiens	5-9
9834113-9	1998	Anti-CD36 blocked uptake into unstimulated or stimulated macrophages, suggesting CD36 involvement not only with the alpha(v)beta3 integrin mechanism (as previously reported) but also with PS recognition.	Phosphatidylserines	188-190	CD36 molecule	Homo sapiens	81-85
9811734-9	1998	The requirement of NS1(O) reactivation for characteristic PKC cofactors such as Ca2+/phosphatidylserine or phorbol esters strongly suggests the involvement of this protein kinase family in regulation of NS1 replicative functions in vitro.	Phosphatidylserines	85-103	influenza virus NS1A binding protein	Homo sapiens	19-25
9811734-9	1998	The requirement of NS1(O) reactivation for characteristic PKC cofactors such as Ca2+/phosphatidylserine or phorbol esters strongly suggests the involvement of this protein kinase family in regulation of NS1 replicative functions in vitro.	Phosphatidylserines	85-103	influenza virus NS1A binding protein	Homo sapiens	19-22
9819208-2	1998	We report here new data concerning the nature of the interaction of apoA-I with condensed phospholipid (PL) monolayers (phosphatidylcholine and phosphatidylserine).	Phosphatidylserines	144-162	apolipoprotein A1	Homo sapiens	68-74
9817842-1	1998	BACKGROUND: Conventional isoforms (alpha, beta and gamma) of protein kinase C (PKC) are synergistically activated by phosphatidylserine and Ca2+; both bind to C2 domains located within the PKC amino-terminal regulatory regions.	Phosphatidylserines	117-135	protein kinase C beta	Homo sapiens	79-82
9817842-1	1998	BACKGROUND: Conventional isoforms (alpha, beta and gamma) of protein kinase C (PKC) are synergistically activated by phosphatidylserine and Ca2+; both bind to C2 domains located within the PKC amino-terminal regulatory regions.	Phosphatidylserines	117-135	protein kinase C beta	Homo sapiens	189-192
10461011-4	1998	First, in platelets that were stimulated to spread over fibrin or fibrinogen surfaces with adrenaline, addition of thrombin and CaCl(2) caused a potent Ca(2+) signal that in about 30% of the cells was accompanied by exposure of PS.	Phosphatidylserines	228-230	coagulation factor II, thrombin	Homo sapiens	115-123
10461011-6	1998	Second, in platelet-fibrinogen microaggregates that were preformed in the presence of adrenaline, thrombin/CaCl(2) induced PS exposure and bleb formation of about 35% of the cells.	Phosphatidylserines	123-125	coagulation factor II, thrombin	Homo sapiens	98-106
9786940-4	1998	Chemical modification of lysines and cysteines abolished beta2GPI-dependent PS uptake by inhibiting the binding of PS to beta2GPI and the binding of PS.beta2GPI complex to macrophages, respectively.	Phosphatidylserines	76-78	apolipoprotein H	Homo sapiens	57-65
9786940-4	1998	Chemical modification of lysines and cysteines abolished beta2GPI-dependent PS uptake by inhibiting the binding of PS to beta2GPI and the binding of PS.beta2GPI complex to macrophages, respectively.	Phosphatidylserines	76-78	apolipoprotein H	Homo sapiens	121-129
9786940-4	1998	Chemical modification of lysines and cysteines abolished beta2GPI-dependent PS uptake by inhibiting the binding of PS to beta2GPI and the binding of PS.beta2GPI complex to macrophages, respectively.	Phosphatidylserines	76-78	apolipoprotein H	Homo sapiens	121-129
9786940-4	1998	Chemical modification of lysines and cysteines abolished beta2GPI-dependent PS uptake by inhibiting the binding of PS to beta2GPI and the binding of PS.beta2GPI complex to macrophages, respectively.	Phosphatidylserines	115-117	apolipoprotein H	Homo sapiens	57-65
9786940-4	1998	Chemical modification of lysines and cysteines abolished beta2GPI-dependent PS uptake by inhibiting the binding of PS to beta2GPI and the binding of PS.beta2GPI complex to macrophages, respectively.	Phosphatidylserines	115-117	apolipoprotein H	Homo sapiens	121-129
9786940-4	1998	Chemical modification of lysines and cysteines abolished beta2GPI-dependent PS uptake by inhibiting the binding of PS to beta2GPI and the binding of PS.beta2GPI complex to macrophages, respectively.	Phosphatidylserines	115-117	apolipoprotein H	Homo sapiens	121-129
9786940-4	1998	Chemical modification of lysines and cysteines abolished beta2GPI-dependent PS uptake by inhibiting the binding of PS to beta2GPI and the binding of PS.beta2GPI complex to macrophages, respectively.	Phosphatidylserines	115-117	apolipoprotein H	Homo sapiens	57-65
9786940-4	1998	Chemical modification of lysines and cysteines abolished beta2GPI-dependent PS uptake by inhibiting the binding of PS to beta2GPI and the binding of PS.beta2GPI complex to macrophages, respectively.	Phosphatidylserines	115-117	apolipoprotein H	Homo sapiens	121-129
9786940-4	1998	Chemical modification of lysines and cysteines abolished beta2GPI-dependent PS uptake by inhibiting the binding of PS to beta2GPI and the binding of PS.beta2GPI complex to macrophages, respectively.	Phosphatidylserines	115-117	apolipoprotein H	Homo sapiens	121-129
9774403-8	1998	Phosphatidylserine, phosphatidylinositol, and phosphatidylinositol 4,5-bisphosphate, but not phosphatidylcholine or sphingosine, were as effective as GTPgammaS-Rac1 in enhancing MIHCK autophosphorylation and activity.	Phosphatidylserines	0-18	Rac family small GTPase 1	Homo sapiens	160-164
9774404-2	1998	We found that binding of heterotrimeric fVIIIa (A1.A2.A3-C1-C2) to synthetic vesicles with a physiologic content of 4% phosphatidylserine (PS), 76% phosphatidylcholine, and 20% phosphatidylethanolamine occurs with a 10-fold higher affinity than that of factor VIII (fVIII).	Phosphatidylserines	119-137	coagulation factor VIII	Homo sapiens	40-45
9774404-2	1998	We found that binding of heterotrimeric fVIIIa (A1.A2.A3-C1-C2) to synthetic vesicles with a physiologic content of 4% phosphatidylserine (PS), 76% phosphatidylcholine, and 20% phosphatidylethanolamine occurs with a 10-fold higher affinity than that of factor VIII (fVIII).	Phosphatidylserines	139-141	coagulation factor VIII	Homo sapiens	40-45
9774404-3	1998	The increased affinity of fVIIIa for PS-containing membranes resulted from the reduced rate of fVIIIa dissociation from the vesicles compared with that of fVIII.	Phosphatidylserines	37-39	coagulation factor VIII	Homo sapiens	26-31
9774404-5	1998	A3-C1-C2, and A3-C1-C2.heavy chain for interaction with PS-containing membranes demonstrate that removal of the light chain (LCh) acidic region by thrombin is responsible for these increased affinities of fVIIIa and its derivatives.	Phosphatidylserines	56-58	coagulation factor II, thrombin	Homo sapiens	147-155
9774404-6	1998	Similar kinetic parameters of fVIII and its LCh and C2 domain for binding to PS-containing membranes and to activated platelets indicated that the C2 domain is entirely responsible for the interaction of fVIII with membranes.	Phosphatidylserines	77-79	coagulation factor VIII	Homo sapiens	30-35
9774404-8	1998	This conclusion is based on the finding that binding of the monoclonal antibody ESH8 to the C2 domain, which is known to prevent this conformational transition, resulted in fVIIIa binding to PS/phosphatidylcholine/phosphatidylethanolamine vesicles (4/76/20) with a lower affinity similar to that of fVIII.	Phosphatidylserines	191-193	coagulation factor VIII	Homo sapiens	173-178
9767089-1	1998	The cho1/pss mutant of Saccharomyces cerevisiae, which is auxotrophic for choline or ethanolamine because of the deficiency in phosphatidylserine synthesis, grew in the presence of 0.05 mM phosphatidylcholine (PC) with octanoic acids (diC8PC) or decanoic acids (diC10PC), but not in the presence of PC with longer acyl residues.	Phosphatidylserines	127-145	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	4-8
9844818-7	1998	The PI3 kinase seems to be partly involved in the accelerated Phosphatidyl-Serine exposure observed in Bcr-Abl transformed cells.	Phosphatidylserines	62-81	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	103-110
9753467-5	1998	AMVN-induced lipid peroxidation was followed by apoptosis as determined by nuclear condensation, DNA fragmentation, and annexin V binding to externalized phosphatidylserine (PS).	Phosphatidylserines	154-172	annexin A5	Homo sapiens	120-129
9733716-3	1998	Phosphatidylserine (PS), another anionic glycerophospholipid, binds to mCD14 with lower apparent affinity than does PtdIns.	Phosphatidylserines	0-18	CD14 antigen	Mus musculus	71-76
9733716-3	1998	Phosphatidylserine (PS), another anionic glycerophospholipid, binds to mCD14 with lower apparent affinity than does PtdIns.	Phosphatidylserines	20-22	CD14 antigen	Mus musculus	71-76
9689115-7	1998	PS liposome inhibited these LOX-1-mediated interactions with aged/apoptotic cells, suggesting LOX-1 recognizes PS of the apoptotic cells.	Phosphatidylserines	0-2	oxidized low density lipoprotein receptor 1	Bos taurus	28-33
9689115-7	1998	PS liposome inhibited these LOX-1-mediated interactions with aged/apoptotic cells, suggesting LOX-1 recognizes PS of the apoptotic cells.	Phosphatidylserines	0-2	oxidized low density lipoprotein receptor 1	Bos taurus	94-99
10200521-2	1998	The apoptotic phenotype induced by injected cytochrome c was characterized by externalization of phosphatidyl serine, cell detachment from substratum and from neighbor cells, and had the classic ultrastructural features of membrane budding, chromatin condensation and cell shrinkage.	Phosphatidylserines	97-116	cytochrome c, somatic	Homo sapiens	44-56
9826030-2	1998	The calmodulin inhibitor calmidazolium was an efficient inhibitor (50%) of the synaptosomal Ca2+-ATPase activity in a manner competitive with phosphatidylserine.	Phosphatidylserines	142-160	calmodulin 1	Rattus norvegicus	4-14
9622504-9	1998	Phosphatidylserine is not a good replacement for phosphatidylmethanol for inducing high-affinity, calcium-independent binding of cPLA2.	Phosphatidylserines	0-18	phospholipase A2 group IVA	Homo sapiens	129-134
9582361-0	1998	A genetic screen for aminophospholipid transport mutants identifies the phosphatidylinositol 4-kinase, STT4p, as an essential component in phosphatidylserine metabolism.	Phosphatidylserines	139-157	1-phosphatidylinositol 4-kinase STT4	Saccharomyces cerevisiae S288C	103-108
9575216-4	1998	GSSG antagonized the Ca2+- and PS-dependent activity of purified rat brain PKC with the same efficacy (IC50 = 3 mM) whether or not the reductant dithiothreitol was present.	Phosphatidylserines	31-33	protein kinase C alpha	Homo sapiens	75-78
9575216-11	1998	Treatment of cultured rat fibroblast and human breast cancer cell lines with N-acetylcysteine resulted in a substantial loss of Ca2+- and PS- dependent PKC activity in the cells within 30 min.	Phosphatidylserines	138-140	protein kinase C alpha	Homo sapiens	152-155
9649198-8	1998	Beta2-GPI bound to protein C in the presence of CL or phosphatidylserine, but not in the presence of phosphatidylcholine or phosphatidylethanolamine.	Phosphatidylserines	54-72	apolipoprotein H	Homo sapiens	0-9
9649198-8	1998	Beta2-GPI bound to protein C in the presence of CL or phosphatidylserine, but not in the presence of phosphatidylcholine or phosphatidylethanolamine.	Phosphatidylserines	54-72	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	19-28
9556620-7	1998	PCI significantly inhibited APC in the presence of phospholipid vesicles prepared using rabbit brain cephalin (RBC) or a mixture of 40% phosphatidylethanolamine (PE), 20% phosphatidylserine (PS), and 40% phosphatidylcholine (PC) with a second order rate constant of 1.0 x 10(6) M-1.min-1.	Phosphatidylserines	171-189	serpin family A member 5	Homo sapiens	0-3
9556620-7	1998	PCI significantly inhibited APC in the presence of phospholipid vesicles prepared using rabbit brain cephalin (RBC) or a mixture of 40% phosphatidylethanolamine (PE), 20% phosphatidylserine (PS), and 40% phosphatidylcholine (PC) with a second order rate constant of 1.0 x 10(6) M-1.min-1.	Phosphatidylserines	191-193	serpin family A member 5	Homo sapiens	0-3
9652730-5	1998	We conclude that the phosphatidyl serine translocation to the outer leaflet of the cell membrane following an apoptotic signal, as labelled by Annexin V, probably occurs before the development of the DNA strand breaks or the exposure of 7A6 antigen in those cells triggered to die by apoptosis.	Phosphatidylserines	21-40	annexin A5	Homo sapiens	143-152
9553075-11	1998	A peptide from the COOH-terminal region of the C2B domain specifically inhibited ATP-dependent secretion from permeabilized chromaffin cells and the binding of Rabphilin3a to phosphatidylcholine/PS/PtdIns(4,5)P2-containing lipid vesicles, suggesting a role of this sequence in secretion through its ability to interact with acidic lipid vesicles.	Phosphatidylserines	195-197	secretoglobin family 2B member 3, pseudogene	Homo sapiens	47-50
9553075-11	1998	A peptide from the COOH-terminal region of the C2B domain specifically inhibited ATP-dependent secretion from permeabilized chromaffin cells and the binding of Rabphilin3a to phosphatidylcholine/PS/PtdIns(4,5)P2-containing lipid vesicles, suggesting a role of this sequence in secretion through its ability to interact with acidic lipid vesicles.	Phosphatidylserines	195-197	rabphilin 3A	Homo sapiens	160-171
9553124-7	1998	Addition of the cytoplasmic syndecan-4 peptide, but not equivalent syndecan-1 or syndecan-2 peptides, potentiated the partial activation of PKCalpha beta gamma by PIP2, resulting in activity greater than that observed with phosphatidylserine, diolein, and calcium.	Phosphatidylserines	223-241	syndecan 4	Homo sapiens	28-38
9553124-7	1998	Addition of the cytoplasmic syndecan-4 peptide, but not equivalent syndecan-1 or syndecan-2 peptides, potentiated the partial activation of PKCalpha beta gamma by PIP2, resulting in activity greater than that observed with phosphatidylserine, diolein, and calcium.	Phosphatidylserines	223-241	protein kinase C alpha	Homo sapiens	140-148
9555096-7	1998	Hydrolysis of mixed vesicles containing phosphatidylserine and phosphatidylcholine by the venom and pancreatic enzymes were differentially inhibited by annexin V.	Phosphatidylserines	40-58	annexin A5	Homo sapiens	152-161
9538007-3	1998	For PKC-alpha, diacylglycerol (DG) specifically enhanced the binding of PKC-alpha to phosphatidylserine (PS)-containing vesicles by 2 orders of magnitude, allowing PKC-alpha high specificity for PS.	Phosphatidylserines	85-103	protein kinase C, alpha	Rattus norvegicus	72-81
9538007-3	1998	For PKC-alpha, diacylglycerol (DG) specifically enhanced the binding of PKC-alpha to phosphatidylserine (PS)-containing vesicles by 2 orders of magnitude, allowing PKC-alpha high specificity for PS.	Phosphatidylserines	85-103	protein kinase C, alpha	Rattus norvegicus	72-81
9538007-3	1998	For PKC-alpha, diacylglycerol (DG) specifically enhanced the binding of PKC-alpha to phosphatidylserine (PS)-containing vesicles by 2 orders of magnitude, allowing PKC-alpha high specificity for PS.	Phosphatidylserines	105-107	protein kinase C, alpha	Rattus norvegicus	72-81
9538007-3	1998	For PKC-alpha, diacylglycerol (DG) specifically enhanced the binding of PKC-alpha to phosphatidylserine (PS)-containing vesicles by 2 orders of magnitude, allowing PKC-alpha high specificity for PS.	Phosphatidylserines	105-107	protein kinase C, alpha	Rattus norvegicus	72-81
9538007-4	1998	Also, PKC-alpha could penetrate into the phospholipid monolayer with a packing density comparable to that of the cell membrane only in the presence of Ca2+ and PS.	Phosphatidylserines	160-162	protein kinase C, alpha	Rattus norvegicus	6-15
9538007-8	1998	Taken together, these results suggest the following: (1) The role of Ca2+ in the membrane binding of PKC-alpha is to expose a specific PS-binding site.	Phosphatidylserines	135-137	protein kinase C, alpha	Rattus norvegicus	101-110
9538007-9	1998	(2) Once bound to membrane surfaces, PS specifically induces the partial membrane penetration of PKC-alpha that allows its optimal interactions with DG, hence the enhanced membrane binding and activation.	Phosphatidylserines	37-39	protein kinase C, alpha	Rattus norvegicus	97-106
9538022-10	1998	The data suggest that thrombin-activated platelets possess some element(s) (other than 30% phosphatidyl serine or factor Va), presumably either protein or phospholipid, that serves as a component of the factor Xa binding site.	Phosphatidylserines	91-110	coagulation factor II, thrombin	Homo sapiens	22-30
9538022-10	1998	The data suggest that thrombin-activated platelets possess some element(s) (other than 30% phosphatidyl serine or factor Va), presumably either protein or phospholipid, that serves as a component of the factor Xa binding site.	Phosphatidylserines	91-110	coagulation factor X	Homo sapiens	203-212
9586564-2	1998	With increasing concentrations of Ca2+, phosphatidylserine or dioctanoylglycerol in the reaction mixture, regucalcin (10[-8] M) caused a remarkable inhibition of protein kinase C activity.	Phosphatidylserines	40-58	regucalcin	Rattus norvegicus	106-116
9657274-2	1998	Human mannan-binding lectin (MBL) was found to bind specifically to solid-phase phosphatidylserine (PS), phosphatidylinositol (PI) and phosphatidylcholine (PC), but not cardiolipin (CL), in a concentration-dependent manner.	Phosphatidylserines	80-98	mannose binding lectin 2	Homo sapiens	6-27
9657274-2	1998	Human mannan-binding lectin (MBL) was found to bind specifically to solid-phase phosphatidylserine (PS), phosphatidylinositol (PI) and phosphatidylcholine (PC), but not cardiolipin (CL), in a concentration-dependent manner.	Phosphatidylserines	80-98	mannose binding lectin 2	Homo sapiens	29-32
9657274-2	1998	Human mannan-binding lectin (MBL) was found to bind specifically to solid-phase phosphatidylserine (PS), phosphatidylinositol (PI) and phosphatidylcholine (PC), but not cardiolipin (CL), in a concentration-dependent manner.	Phosphatidylserines	100-102	mannose binding lectin 2	Homo sapiens	6-27
9657274-2	1998	Human mannan-binding lectin (MBL) was found to bind specifically to solid-phase phosphatidylserine (PS), phosphatidylinositol (PI) and phosphatidylcholine (PC), but not cardiolipin (CL), in a concentration-dependent manner.	Phosphatidylserines	100-102	mannose binding lectin 2	Homo sapiens	29-32
9724927-2	1998	At high sublytic amphiphile-concentrations the binding of FITC-annexin V, monitored in a flow cytometer, was time- and temperature-dependent and occurred heterogeneously in the cell population, with 43-81% of cells being stained above background following incubation for 60 minutes at 37 degrees C. The increased FITC-annexin V binding apparently indicates an increased flop rate of phosphatidylserine (PS) to the outer membrane leaflet.	Phosphatidylserines	383-401	annexin A5	Homo sapiens	63-72
9516463-4	1998	In vitro phosphorylation of endogenous moesin, which was identified by peptide microsequencing, was dependent on phosphatidylglycerol (PG) or to a lesser extent, phosphatidylinositol (PI), but not phosphatidylserine (PS) and diacylglycerol (DAG).	Phosphatidylserines	197-215	moesin	Homo sapiens	39-45
9516463-4	1998	In vitro phosphorylation of endogenous moesin, which was identified by peptide microsequencing, was dependent on phosphatidylglycerol (PG) or to a lesser extent, phosphatidylinositol (PI), but not phosphatidylserine (PS) and diacylglycerol (DAG).	Phosphatidylserines	217-219	moesin	Homo sapiens	39-45
9510174-0	1998	CD4+, but not CD8+, T cells from mammary tumor-bearing mice have a down-regulated production of IFN-gamma: role of phosphatidyl serine.	Phosphatidylserines	115-134	CD4 antigen	Mus musculus	0-3
9510174-5	1998	Interestingly, phosphatidyl serine (PS) down-regulated the IFN-gamma production of CD4+, but not that of CD8+, T cells.	Phosphatidylserines	15-34	interferon gamma	Mus musculus	59-68
9510174-5	1998	Interestingly, phosphatidyl serine (PS) down-regulated the IFN-gamma production of CD4+, but not that of CD8+, T cells.	Phosphatidylserines	15-34	CD4 antigen	Mus musculus	83-86
9510174-5	1998	Interestingly, phosphatidyl serine (PS) down-regulated the IFN-gamma production of CD4+, but not that of CD8+, T cells.	Phosphatidylserines	36-38	interferon gamma	Mus musculus	59-68
9510174-5	1998	Interestingly, phosphatidyl serine (PS) down-regulated the IFN-gamma production of CD4+, but not that of CD8+, T cells.	Phosphatidylserines	36-38	CD4 antigen	Mus musculus	83-86
9510174-6	1998	Methylation analysis indicated that the CpG dinucleotide in SnaBI site of the IFN-gamma 5" promoter flank region was hypermethylated in CD4+, but not in CD8+, T cells of large tumor bearers and of normal mice pretreated with PS.	Phosphatidylserines	225-227	interferon gamma	Mus musculus	78-87
9510174-6	1998	Methylation analysis indicated that the CpG dinucleotide in SnaBI site of the IFN-gamma 5" promoter flank region was hypermethylated in CD4+, but not in CD8+, T cells of large tumor bearers and of normal mice pretreated with PS.	Phosphatidylserines	225-227	CD4 antigen	Mus musculus	136-139
9521652-8	1998	Collectively, our results show that phosphatidylserine containing membranes will accumulate tightly bound TFPI-factor Xa complexes, and that uncomplexed, phospholipid-bound, factor Xa, will cause limited proteolysis of TFPI accompanied by simultaneous release of these complexes from the phospholipid membrane.	Phosphatidylserines	36-54	tissue factor pathway inhibitor	Homo sapiens	106-110
9521652-8	1998	Collectively, our results show that phosphatidylserine containing membranes will accumulate tightly bound TFPI-factor Xa complexes, and that uncomplexed, phospholipid-bound, factor Xa, will cause limited proteolysis of TFPI accompanied by simultaneous release of these complexes from the phospholipid membrane.	Phosphatidylserines	36-54	coagulation factor X	Homo sapiens	111-120
9480874-3	1998	Annexin VI and PKC alpha are both calcium-dependent phospholipid-binding proteins, and detection of the interaction was dependent on the presence of calcium and phosphatidylserine (PS).	Phosphatidylserines	161-179	protein kinase C alpha	Homo sapiens	15-24
9480874-3	1998	Annexin VI and PKC alpha are both calcium-dependent phospholipid-binding proteins, and detection of the interaction was dependent on the presence of calcium and phosphatidylserine (PS).	Phosphatidylserines	181-183	protein kinase C alpha	Homo sapiens	15-24
9506836-9	1998	These results demonstrate that the PKC-gamma Cys-2 domain beside being the binding site for phorbol ester/DAG and phosphatidylserine binds also other proteins.	Phosphatidylserines	114-132	protein kinase C, gamma	Rattus norvegicus	35-44
9477969-0	1998	Influence of annexin V on the structure and dynamics of phosphatidylcholine/phosphatidylserine bilayers: a fluorescence and NMR study.	Phosphatidylserines	76-94	annexin A5	Homo sapiens	13-22
9533686-1	1998	Direct fluorescence digital imaging microscopy observations demonstrate that a basic peptide corresponding to the effector region of the myristoylated alanine-rich C kinase substrate (MARCKS) self-assembles into membrane domains enriched in the acidic phospholipids phosphatidylserine (PS) and phosphatidylinositol 4,5-bisphosphate (PIP2).	Phosphatidylserines	266-284	myristoylated alanine rich protein kinase C substrate	Homo sapiens	137-182
9533686-1	1998	Direct fluorescence digital imaging microscopy observations demonstrate that a basic peptide corresponding to the effector region of the myristoylated alanine-rich C kinase substrate (MARCKS) self-assembles into membrane domains enriched in the acidic phospholipids phosphatidylserine (PS) and phosphatidylinositol 4,5-bisphosphate (PIP2).	Phosphatidylserines	266-284	myristoylated alanine rich protein kinase C substrate	Homo sapiens	184-190
9533686-1	1998	Direct fluorescence digital imaging microscopy observations demonstrate that a basic peptide corresponding to the effector region of the myristoylated alanine-rich C kinase substrate (MARCKS) self-assembles into membrane domains enriched in the acidic phospholipids phosphatidylserine (PS) and phosphatidylinositol 4,5-bisphosphate (PIP2).	Phosphatidylserines	286-288	myristoylated alanine rich protein kinase C substrate	Homo sapiens	137-182
9533686-1	1998	Direct fluorescence digital imaging microscopy observations demonstrate that a basic peptide corresponding to the effector region of the myristoylated alanine-rich C kinase substrate (MARCKS) self-assembles into membrane domains enriched in the acidic phospholipids phosphatidylserine (PS) and phosphatidylinositol 4,5-bisphosphate (PIP2).	Phosphatidylserines	286-288	myristoylated alanine rich protein kinase C substrate	Homo sapiens	184-190
9493579-8	1998	Factor IXa-induced generation of factor Xa and thrombin was only observed when contact activated plasma was subsequently perfused through a DOPS/DOPC-coated capillary, showing that propagation of the factor IXa trigger requires a procoagulant, phosphatidylserine-containing, phospholipid membrane.	Phosphatidylserines	244-262	coagulation factor II, thrombin	Homo sapiens	47-55
9468299-8	1998	In the presence of activating cofactors, such as phosphatidylserine and TPA or cholesterol sulfate (for PKCzeta), the activity of the aPKCzeta is further stimulated, PKCmu is not significantly affected, and the cPKCs and the nPKCdelta are strongly inhibited by suramin.	Phosphatidylserines	49-67	protein kinase C zeta	Homo sapiens	104-111
9468299-8	1998	In the presence of activating cofactors, such as phosphatidylserine and TPA or cholesterol sulfate (for PKCzeta), the activity of the aPKCzeta is further stimulated, PKCmu is not significantly affected, and the cPKCs and the nPKCdelta are strongly inhibited by suramin.	Phosphatidylserines	49-67	protein kinase D1	Homo sapiens	166-171
9450519-6	1998	Annexin V was shown to interact strongly and specifically with PS and can be used to detect apoptosis by targeting for the loss of plasma membrane asymmetry.	Phosphatidylserines	63-65	annexin A5	Homo sapiens	0-9
9463889-8	1998	Incorporation of phosphatidylethanolamine or phosphatidylserine into phosphatidylcholine vesicles reduced the binding of PDC-109, suggesting that both the density of phosphorylcholine groups and the surface charge determine the interaction of the seminal plasma protein with the surface of the membrane.	Phosphatidylserines	45-63	seminal plasma protein PDC-109	Bos taurus	121-128
9481780-6	1998	Secreted PLA2 isozymes that display a substrate preference for the negatively charged aminophospholipids (e.g. phosphatidylserine or phosphatidylethanolamine) in the exoplasmic membrane may affect cell function and reactivity via a process of "membrane polishing", that is, the preferentially removal of aminophospholipids from the exoplasmic leaflet of the cell membranes.	Phosphatidylserines	111-129	phospholipase A2 group IIA	Homo sapiens	9-13
9405440-7	1997	Moreover, this GST-Nedd4-C2 domain was able to mediate Ca2+-dependent interactions with phosphatidylserine, phosphatidylinositol, and phosphatidylcholine liposomes in vitro.	Phosphatidylserines	88-106	NEDD4 E3 ubiquitin protein ligase	Canis lupus familiaris	19-24
9416833-3	1997	The RalGDS activity was inhibited by acidic membrane phospholipids such as phosphatidylinositol and phosphatidylserine but not by phosphatidylcholine or phosphatidylethanolamine in vitro.	Phosphatidylserines	100-118	ral guanine nucleotide dissociation stimulator	Homo sapiens	4-10
9388264-11	1997	This enhanced uptake was maintained even after PS was "shielded" with beta2GPI and further increased upon the addition of beta2GPI antibodies.	Phosphatidylserines	47-49	apolipoprotein H	Homo sapiens	70-78
9388264-11	1997	This enhanced uptake was maintained even after PS was "shielded" with beta2GPI and further increased upon the addition of beta2GPI antibodies.	Phosphatidylserines	47-49	apolipoprotein H	Homo sapiens	122-130
9498570-0	1997	Localization of the phosphatidylserine-binding site of glyceraldehyde-3-phosphate dehydrogenase responsible for membrane fusion.	Phosphatidylserines	20-38	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	55-95
9498570-3	1997	One polyclonal antibody, designated aPSD-2, crossreacted with GAPDH, and its binding to GAPDH was inhibited by PS but not by other phospholipids such as phosphatidylethanolamine and phosphatidylinositol.	Phosphatidylserines	37-39	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	62-67
9498570-3	1997	One polyclonal antibody, designated aPSD-2, crossreacted with GAPDH, and its binding to GAPDH was inhibited by PS but not by other phospholipids such as phosphatidylethanolamine and phosphatidylinositol.	Phosphatidylserines	37-39	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	88-93
9498570-4	1997	Kinetic analysis of GAPDH binding to phospholipid membranes by measuring surface plasmon resonance showed that GAPDH associated with the phospholipid membrane containing PS rapidly (k[on] =2.8 X 10(4) M(-1) X s[-1]) and dissociated extremely slowly (k[off]=5.9 X 10(-5) s[-1]), giving a low dissociation constant (KD=2.6nM).	Phosphatidylserines	170-172	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	20-25
9498570-4	1997	Kinetic analysis of GAPDH binding to phospholipid membranes by measuring surface plasmon resonance showed that GAPDH associated with the phospholipid membrane containing PS rapidly (k[on] =2.8 X 10(4) M(-1) X s[-1]) and dissociated extremely slowly (k[off]=5.9 X 10(-5) s[-1]), giving a low dissociation constant (KD=2.6nM).	Phosphatidylserines	170-172	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	111-116
9498570-5	1997	GAPDH bound less effectively to membranes without PS with a dissociation constants of 0.2 microM.	Phosphatidylserines	50-52	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	0-5
9366400-3	1997	Cross-linking of CD45 on thymocytes by mAbs led to the induction of cellular death, characterized by a reduction in mitochondrial membrane potential (delta psi(m)), production of reactive oxygen species, loss in membrane asymmetry, exposure of phosphatidylserine residues, and incorporation of vital dyes.	Phosphatidylserines	244-262	protein tyrosine phosphatase receptor type C	Homo sapiens	17-21
9406164-6	1997	Ca2+/ phosphatidylserine/sn-1,2 diolein-dependent 32P incorporation catalyzed by excess of purified rat brain protein kinase C in C-protein, TnT and TnI subunits did not show any differences between myofibrils from non-stunned and stunned myocardium.	Phosphatidylserines	6-24	troponin T3, fast skeletal type	Rattus norvegicus	141-144
9406164-6	1997	Ca2+/ phosphatidylserine/sn-1,2 diolein-dependent 32P incorporation catalyzed by excess of purified rat brain protein kinase C in C-protein, TnT and TnI subunits did not show any differences between myofibrils from non-stunned and stunned myocardium.	Phosphatidylserines	6-24	troponin I3, cardiac type	Rattus norvegicus	149-152
9334182-2	1997	The mechanism of PS appearance during apoptosis is not well understood but has been associated with loss of aminophospholipid translocase activity and nonspecific flip-flop of phospholipids of various classes.	Phosphatidylserines	17-19	ATPase phospholipid transporting 8A1	Homo sapiens	108-137
9334182-6	1997	Furthermore, while both the appearance of PS and nonspecific phospholipid uptake demonstrated identical extracellular calcium requirements with an ED50 of nearly 100 microM, the magnitude of PS appearance depended on the level of aminophospholipid translocase activity.	Phosphatidylserines	191-193	ATPase phospholipid transporting 8A1	Homo sapiens	230-259
9359412-2	1997	Neither enzyme binds appreciably to pure phosphatidylcholine vesicles at lipid concentrations up to 10(-3) M. PLC-beta1 and PLC-beta2 bind vesicles composed of phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine (molar ratio 1:1:1) with an approximate Kd of 10(-5) M. Inclusion of 2% PtdIns(4,5)P2 in these vesicles had no effect on the affinity of this interaction.	Phosphatidylserines	181-199	phospholipase C beta 1	Homo sapiens	110-119
9359412-2	1997	Neither enzyme binds appreciably to pure phosphatidylcholine vesicles at lipid concentrations up to 10(-3) M. PLC-beta1 and PLC-beta2 bind vesicles composed of phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine (molar ratio 1:1:1) with an approximate Kd of 10(-5) M. Inclusion of 2% PtdIns(4,5)P2 in these vesicles had no effect on the affinity of this interaction.	Phosphatidylserines	181-199	phospholipase C beta 2	Homo sapiens	124-133
9312108-4	1997	FRET was observed when Fl-FPR-APC was titrated in the presence of Ca2+ ions with phosphatidylcholine/phosphatidylserine (4:1) vesicles containing the FRET acceptor, octadecylrhodamine (OR).	Phosphatidylserines	101-119	APC regulator of WNT signaling pathway	Homo sapiens	30-33
9436535-7	1997	Further scrutiny of this fraction indicates that a) it shows the greatest reactivity with annexin V, which is specific for the detection of phosphatidylserine (PS) exposed on the outer leaflet of the erythrocyte membrane, b) it is the most susceptible to erythrophagocytosis by resident murine peritoneal macrophages, and c) this erythrophagocytosis of PKH 26-labeled erythrocytes can be inhibited by annexin V and by liposomes containing PS.	Phosphatidylserines	140-158	annexin A5	Mus musculus	90-99
9436535-7	1997	Further scrutiny of this fraction indicates that a) it shows the greatest reactivity with annexin V, which is specific for the detection of phosphatidylserine (PS) exposed on the outer leaflet of the erythrocyte membrane, b) it is the most susceptible to erythrophagocytosis by resident murine peritoneal macrophages, and c) this erythrophagocytosis of PKH 26-labeled erythrocytes can be inhibited by annexin V and by liposomes containing PS.	Phosphatidylserines	160-162	annexin A5	Mus musculus	90-99
9436535-7	1997	Further scrutiny of this fraction indicates that a) it shows the greatest reactivity with annexin V, which is specific for the detection of phosphatidylserine (PS) exposed on the outer leaflet of the erythrocyte membrane, b) it is the most susceptible to erythrophagocytosis by resident murine peritoneal macrophages, and c) this erythrophagocytosis of PKH 26-labeled erythrocytes can be inhibited by annexin V and by liposomes containing PS.	Phosphatidylserines	439-441	annexin A5	Mus musculus	90-99
9379487-2	1997	In the present study, exposure to excess phosphatidyl serine (PS) for < 1 min induced antigenic alterations in multiple N-terminal, C-terminal and central epitopes of purified human brain tau.	Phosphatidylserines	62-64	microtubule associated protein tau	Homo sapiens	188-191
9379487-3	1997	Notably, "AD-like" epitopes (PHF-1, ALZ-50, AT-8) were decreased by PS; other epitopes (e.g., 5E2, Tau-1) increased and others remained relatively unchanged.	Phosphatidylserines	68-70	PHD finger protein 1	Homo sapiens	29-34
9379487-7	1997	PS inhibited MAP-kinase generation of phospho-dependent tau epitopes and incorporation of phosphates by tau.	Phosphatidylserines	0-2	regulator of microtubule dynamics 1	Homo sapiens	13-16
9379487-7	1997	PS inhibited MAP-kinase generation of phospho-dependent tau epitopes and incorporation of phosphates by tau.	Phosphatidylserines	0-2	microtubule associated protein tau	Homo sapiens	56-59
9379487-7	1997	PS inhibited MAP-kinase generation of phospho-dependent tau epitopes and incorporation of phosphates by tau.	Phosphatidylserines	0-2	microtubule associated protein tau	Homo sapiens	104-107
9379487-8	1997	Inclusion of PS during coincubation of tau and tubulin reduced the extent of cosedimentation of tau with MTs.	Phosphatidylserines	13-15	microtubule associated protein tau	Homo sapiens	39-42
9379487-8	1997	Inclusion of PS during coincubation of tau and tubulin reduced the extent of cosedimentation of tau with MTs.	Phosphatidylserines	13-15	microtubule associated protein tau	Homo sapiens	96-99
9379487-9	1997	Finally, PS enhanced the ability of calpain-mediated tau proteolysis.	Phosphatidylserines	9-11	microtubule associated protein tau	Homo sapiens	53-56
9315725-4	1997	L-MBP also bound to phosphatidylglycerol and weakly to phosphatidylserine.	Phosphatidylserines	55-73	myelin basic protein	Rattus norvegicus	2-5
9278459-3	1997	In the present study, we show that MAP1B purified from young rat brain can bind to acidic phospholipids, such as phosphatidylserine, but not to a neutral phospholipid, phosphatidylcholine.	Phosphatidylserines	113-131	microtubule-associated protein 1B	Rattus norvegicus	35-40
9278459-4	1997	Furthermore, the binding of MAP1B to taxol-stabilized microtubules was inhibited by the addition of phosphatidylserine or phosphatidylinositol.	Phosphatidylserines	100-118	microtubule-associated protein 1B	Rattus norvegicus	28-33
9284327-2	1997	To determine the PS-binding sites of caldesmon, we have made use of synthetic peptides covering the two C-terminal calmodulin binding sites and a recombinant fragment corresponding to the N-terminal end of the C-terminal domain that contains an amphipathic helix.	Phosphatidylserines	17-19	caldesmon 1	Homo sapiens	37-46
9284327-5	1997	The affinity (Kd) of PS for these sites was in the range of 1.8-14.3 x 10(-5) M, compared to 0.69 x 10(-5) M for the whole caldesmon molecule.	Phosphatidylserines	21-23	caldesmon 1	Homo sapiens	123-132
9298227-6	1997	Once on the cell surface, PS can be specifically detected by staining with fluorescein isothiocyanate (FITC)-labeled annexin V (annexin V-FITC), a protein with a strong, natural affinity for PS.	Phosphatidylserines	26-28	annexin A5	Homo sapiens	117-126
9298227-6	1997	Once on the cell surface, PS can be specifically detected by staining with fluorescein isothiocyanate (FITC)-labeled annexin V (annexin V-FITC), a protein with a strong, natural affinity for PS.	Phosphatidylserines	26-28	annexin A5	Homo sapiens	128-137
9298227-6	1997	Once on the cell surface, PS can be specifically detected by staining with fluorescein isothiocyanate (FITC)-labeled annexin V (annexin V-FITC), a protein with a strong, natural affinity for PS.	Phosphatidylserines	191-193	annexin A5	Homo sapiens	117-126
9298227-6	1997	Once on the cell surface, PS can be specifically detected by staining with fluorescein isothiocyanate (FITC)-labeled annexin V (annexin V-FITC), a protein with a strong, natural affinity for PS.	Phosphatidylserines	191-193	annexin A5	Homo sapiens	128-137
9294443-1	1997	In the yeast Saccharomyces cerevisiae, the products of two genes (PSD1 and PSD2) are able to catalyze the decarboxylation of phosphatidylserine (PS) to produce phosphatidylethanolamine (PE) (C. J. Clancey, S. Chang, and W. Dowhan, J. Biol.	Phosphatidylserines	125-143	phosphatidylserine decarboxylase 1	Saccharomyces cerevisiae S288C	66-70
9294443-1	1997	In the yeast Saccharomyces cerevisiae, the products of two genes (PSD1 and PSD2) are able to catalyze the decarboxylation of phosphatidylserine (PS) to produce phosphatidylethanolamine (PE) (C. J. Clancey, S. Chang, and W. Dowhan, J. Biol.	Phosphatidylserines	125-143	phosphatidylserine decarboxylase 2	Saccharomyces cerevisiae S288C	75-79
9294443-1	1997	In the yeast Saccharomyces cerevisiae, the products of two genes (PSD1 and PSD2) are able to catalyze the decarboxylation of phosphatidylserine (PS) to produce phosphatidylethanolamine (PE) (C. J. Clancey, S. Chang, and W. Dowhan, J. Biol.	Phosphatidylserines	66-68	phosphatidylserine decarboxylase 2	Saccharomyces cerevisiae S288C	75-79
9268710-3	1997	It was found that kinase FA/GSK-3alpha can associate with NaOH-extracted brain membranes and selectively interact with several kinds of reconstituted phospholipid vesicles including phosphatidic acid (PA), phosphatidyl ethanolamine (PE), phosphatidyl inositol (PI), and phosphatidyl serine (PS) vesicles.	Phosphatidylserines	270-289	glycogen synthase kinase 3 alpha	Homo sapiens	28-38
9268710-3	1997	It was found that kinase FA/GSK-3alpha can associate with NaOH-extracted brain membranes and selectively interact with several kinds of reconstituted phospholipid vesicles including phosphatidic acid (PA), phosphatidyl ethanolamine (PE), phosphatidyl inositol (PI), and phosphatidyl serine (PS) vesicles.	Phosphatidylserines	291-293	glycogen synthase kinase 3 alpha	Homo sapiens	28-38
9260748-7	1997	The phospholipid asymmetry of NF1T plasma membrane followed the general features of phospholipid asymmetry in eukaryotic cells: sphingomyelin and phosphatidylcholine were preferentially located in the outer leaflet (90% and 89%, respectively) while the aminophospholipids phosphatidylethanolamine, phosphatidylserine, and phosphatidylinositol were in the inner half of the membrane (85%, 96%, and 69%, respectively).	Phosphatidylserines	298-316	neurofibromin 1	Homo sapiens	30-33
9263986-10	1997	Phospho-L-serine as an antagonist of the phosphatidylserine (PS) mediated recognition pathway for apoptotic cell disposal was able to reduce binding and IL-6 production by HMC but not phagocytosis.	Phosphatidylserines	41-59	interleukin 6	Homo sapiens	153-157
9263986-10	1997	Phospho-L-serine as an antagonist of the phosphatidylserine (PS) mediated recognition pathway for apoptotic cell disposal was able to reduce binding and IL-6 production by HMC but not phagocytosis.	Phosphatidylserines	61-63	interleukin 6	Homo sapiens	153-157
9263986-15	1997	In conclusion, apoptotic monocytic cells provoked an enhanced mesangial IL-6 synthesis by a PS-dependent recognition mechanism.	Phosphatidylserines	92-94	interleukin 6	Homo sapiens	72-76
9201993-10	1997	At acidic pH values, Sap C bound to PS-containing LUV and promoted the association of glucosylceramidase with the membrane.	Phosphatidylserines	36-38	SH2 domain containing 1A	Homo sapiens	21-24
9201968-0	1997	Annexin V interaction with phosphatidylserine-containing vesicles at low and neutral pH.	Phosphatidylserines	27-45	annexin A5	Homo sapiens	0-9
9201968-3	1997	In this study, the interaction of annexin V with large unilamellar vesicles (LUV) prepared from phosphatidylserine (PS) at low pH was compared to that at neutral pH.	Phosphatidylserines	96-114	annexin A5	Homo sapiens	34-43
9201968-3	1997	In this study, the interaction of annexin V with large unilamellar vesicles (LUV) prepared from phosphatidylserine (PS) at low pH was compared to that at neutral pH.	Phosphatidylserines	116-118	annexin A5	Homo sapiens	34-43
9394292-2	1997	Endogenous PS exposure was measured by prothrombinase activity.	Phosphatidylserines	11-13	coagulation factor X	Homo sapiens	39-53
9185174-6	1997	Both enzymes required phospholipids and Ca2+ for activation with rat brain PKC depending almost exclusively on phosphatidylserine.	Phosphatidylserines	111-129	protein kinase C, gamma	Rattus norvegicus	75-78
9185174-7	1997	Bat PKC, however, made use of other phospholipids and showed relative activities of 100:81:33:42 for euthermic PKC and 100:91:45:35 for hibernator PKC with phosphatidylserine, phosphatidylinositol, phosphatidylcholine, and phosphatidylethanolamine (each at 50 microM), respectively.	Phosphatidylserines	156-174	protein kinase C, gamma	Rattus norvegicus	4-7
9250704-2	1997	Asymmetry is maintained by a membrane associated ATP-dependent aminophospholipid translocase that preferentially relocates PS and PE from the outer to the inner monolayer.	Phosphatidylserines	123-125	ATPase phospholipid transporting 8A1	Homo sapiens	63-92
9237616-5	1997	On the other hand, phosphatidylserine, phosphatidic acid, phosphatidylinositol, and phosphatidylinositol 4-phosphate but not phosphatidylcholine stimulated the c-Src activity itself.	Phosphatidylserines	19-37	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	160-165
9188469-9	1997	hGX sPLA2 prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.	Phosphatidylserines	89-107	phospholipase A2 group X	Homo sapiens	4-9
9200713-4	1997	Using a sedimentation assay, gizzard myosin phosphatase bound to vesicles of acidic phospholipids, i.e. phosphatidylserine (PS), phosphatidylinositol, and phosphatidic acid (PA).	Phosphatidylserines	104-122	myosin heavy chain 14	Homo sapiens	37-43
9200713-4	1997	Using a sedimentation assay, gizzard myosin phosphatase bound to vesicles of acidic phospholipids, i.e. phosphatidylserine (PS), phosphatidylinositol, and phosphatidic acid (PA).	Phosphatidylserines	124-126	myosin heavy chain 14	Homo sapiens	37-43
9200713-9	1997	The extent of PS binding with myosin phosphatase decreased on increasing ionic strength and Mg2+ concentration.	Phosphatidylserines	14-16	myosin heavy chain 14	Homo sapiens	30-36
9202175-1	1997	Phospholipids are normally asymmetrically distributed between leaflets of the plasma membrane, due to the activity of aminophospholipid translocase (APT), a putative plasma membrane Mg2(+)-ATPase which is thought to selectively transport phosphatidylserine (PS) and other aminophospholipids from outer to inner membrane leaflet.	Phosphatidylserines	238-256	ATPase, class I, type 8B, member 1	Mus musculus	118-147
9202175-1	1997	Phospholipids are normally asymmetrically distributed between leaflets of the plasma membrane, due to the activity of aminophospholipid translocase (APT), a putative plasma membrane Mg2(+)-ATPase which is thought to selectively transport phosphatidylserine (PS) and other aminophospholipids from outer to inner membrane leaflet.	Phosphatidylserines	238-256	ATPase, class I, type 8B, member 1	Mus musculus	149-152
9168036-6	1997	Values of the equilibrium dissociation constants calculated from the concentration dependence of delta(pi) indicated that the affinity of prothrombin for LE monolayers was higher at higher PS contents and lower packing densities.	Phosphatidylserines	189-191	coagulation factor II, thrombin	Bos taurus	138-149
9168822-6	1997	The specific binding of FL-SA-Ro to the apoptotic cells was also confirmed using a flourescence-activated cell sorter and the time-dependent cell surface exposure of PE correlated well with the exposure of PS, as detected by the binding of annexin V.	Phosphatidylserines	206-208	annexin A5	Mus musculus	240-249
9143244-4	1997	Phosphatidylserine (PS), a major anionic phospholipid of mammalian cells, has been proposed to function as a regulator of immune and inflammatory responses, especially reducing TNF-alpha production and release in mice.	Phosphatidylserines	0-18	tumor necrosis factor	Homo sapiens	177-186
9143244-4	1997	Phosphatidylserine (PS), a major anionic phospholipid of mammalian cells, has been proposed to function as a regulator of immune and inflammatory responses, especially reducing TNF-alpha production and release in mice.	Phosphatidylserines	20-22	tumor necrosis factor	Homo sapiens	177-186
9143244-12	1997	These data suggest that administration of PS suppresses TMEV-IDD by suppressing TNF-alpha production in the effector phase.	Phosphatidylserines	42-44	tumor necrosis factor	Mus musculus	80-89
9109682-9	1997	Since both prothrombin and meizothrombin behave in solution as oblate ellipsoids of revolution with a long axis of 120 A, our FRET measurements suggest that binding to PS-containing membranes induced tighter folding of the prothrombin molecule but not of the meizothrombin intermediate.	Phosphatidylserines	168-170	coagulation factor II, thrombin	Bos taurus	11-22
9109682-9	1997	Since both prothrombin and meizothrombin behave in solution as oblate ellipsoids of revolution with a long axis of 120 A, our FRET measurements suggest that binding to PS-containing membranes induced tighter folding of the prothrombin molecule but not of the meizothrombin intermediate.	Phosphatidylserines	168-170	coagulation factor II, thrombin	Bos taurus	223-234
9163333-2	1997	Here we describe the effect of Mg2+ on phospholipid binding to the C2A domains of multiple synaptotagmins (II-VI), and demonstrate that only synaptotagmin III can bind negatively charged phospholipids [phosphatidylserine (PS) and phosphatidylinositol] in a Mg2+-dependent manner.	Phosphatidylserines	202-220	synaptotagmin 3	Homo sapiens	141-158
9163333-2	1997	Here we describe the effect of Mg2+ on phospholipid binding to the C2A domains of multiple synaptotagmins (II-VI), and demonstrate that only synaptotagmin III can bind negatively charged phospholipids [phosphatidylserine (PS) and phosphatidylinositol] in a Mg2+-dependent manner.	Phosphatidylserines	222-224	synaptotagmin 3	Homo sapiens	141-158
9103463-7	1997	3) Inclusion of sCD14 is absolutely necessary to observe LBP-dependent neutralization of LPS by sphingomyelin, globoside, and phosphatidylserine.	Phosphatidylserines	126-144	lipopolysaccharide binding protein	Homo sapiens	57-60
9089283-5	1997	The decreased phosphatidylserine synthesis induced when triggering the CD3-TCR complex was impaired by AHF, suggesting that p56(lck) could be implicated in the regulation of the serine-base exchange enzyme system.	Phosphatidylserines	14-32	cyclin dependent kinase like 2	Homo sapiens	124-127
9089283-5	1997	The decreased phosphatidylserine synthesis induced when triggering the CD3-TCR complex was impaired by AHF, suggesting that p56(lck) could be implicated in the regulation of the serine-base exchange enzyme system.	Phosphatidylserines	14-32	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	128-131
9116015-9	1997	Interestingly, a significant Ca2+ influx in the presence of annexin V occurred only in liposomes containing a high phosphatidylserine content.	Phosphatidylserines	115-133	annexin A5	Homo sapiens	60-69
9054396-5	1997	This new PLD activity was partially stimulated by phosphatidylinositol 4-phosphate, but not by other phospholipids, including phosphatidylinositol, phosphatidylserine, phosphatidylglycerol, phosphatidic acid, or phosphatidylcholine.	Phosphatidylserines	148-166	phospholipase D alpha 1	Arabidopsis thaliana	9-12
9045633-4	1997	Studies of the activation of protein C in the presence of recombinant soluble thrombomodulin (TM) show TM-dependent stimulation of protein C activation by all three enzymes and, in the presence of phosphatidylserine/phosphatidylcholine phospholipid vesicles, rMZa is 6-fold more potent than rIIa.	Phosphatidylserines	197-215	thrombomodulin	Homo sapiens	78-92
9045633-4	1997	Studies of the activation of protein C in the presence of recombinant soluble thrombomodulin (TM) show TM-dependent stimulation of protein C activation by all three enzymes and, in the presence of phosphatidylserine/phosphatidylcholine phospholipid vesicles, rMZa is 6-fold more potent than rIIa.	Phosphatidylserines	197-215	thrombomodulin	Homo sapiens	94-96
9084877-6	1997	We also performed inhibition assays of carbohydrate binding and of phosphatidylserine/phosphatidylcholine liposome binding of recombinant p33/41 (annexin IV) with anti-p33/41 monoclonal antibodies (AS11 and AS17).	Phosphatidylserines	67-85	annexin A4	Bos taurus	146-156
9047367-2	1997	A three-dimensional (3D) reconstruction of BBMI was made from images of negatively stained, two-dimensional (2D) crystals grown on lipid monolayers formed from mixtures of phosphatidylserine and phosphatidylcholine.	Phosphatidylserines	172-190	myosin IA	Homo sapiens	43-47
9078257-11	1997	The presence of negatively charged lipid (phosphatidylserine or oleic acid) decreased the rate of association of CETP with the emulsion without a significant change in the dissociation rate constant.	Phosphatidylserines	42-60	cholesteryl ester transfer protein	Homo sapiens	113-117
9029120-0	1997	Phosphatidyl serine is involved in the reduced rate of transcription of the inducible nitric oxide synthase gene in macrophages from tumor-bearing mice.	Phosphatidylserines	0-19	nitric oxide synthase 2, inducible	Mus musculus	76-107
9029120-6	1997	In contrast, phosphatidyl serine caused a concentration-dependent inhibition of these functions in response to LPS, which could be partially overcome by the addition of IFN-gamma.	Phosphatidylserines	13-32	interferon gamma	Mus musculus	169-178
9037194-2	1997	Planar membranes, consisting of phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine (PC/PE/PS; 54:33:13, on molar basis), were degraded by pancreatic PLA2, and the rate of hydrolysis was limited to about 0.7%/min.	Phosphatidylserines	83-101	phospholipase A2 group IB	Homo sapiens	168-172
9032461-5	1997	Kinetic analysis of recombinant hs-PLA2 demonstrates that hs-PLA2 strongly prefers PA as substrate over other phospholipids found in the mammalian plasma membrane including phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE).	Phosphatidylserines	173-191	phospholipase A2 group IB	Homo sapiens	32-39
9032461-5	1997	Kinetic analysis of recombinant hs-PLA2 demonstrates that hs-PLA2 strongly prefers PA as substrate over other phospholipids found in the mammalian plasma membrane including phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE).	Phosphatidylserines	173-191	phospholipase A2 group IB	Homo sapiens	58-65
9032461-5	1997	Kinetic analysis of recombinant hs-PLA2 demonstrates that hs-PLA2 strongly prefers PA as substrate over other phospholipids found in the mammalian plasma membrane including phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE).	Phosphatidylserines	193-195	phospholipase A2 group IB	Homo sapiens	32-39
9032461-5	1997	Kinetic analysis of recombinant hs-PLA2 demonstrates that hs-PLA2 strongly prefers PA as substrate over other phospholipids found in the mammalian plasma membrane including phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE).	Phosphatidylserines	193-195	phospholipase A2 group IB	Homo sapiens	58-65
9017186-6	1997	As shown by CD experiments, helical conformer was induced for NG(28-43) in vesicular solution containing phosphatidyl serine (PS), whereas no helix can be discerned for the peptide in phosphatidyl choline (PC)-containing vesicular solution.	Phosphatidylserines	105-124	neurogranin	Homo sapiens	62-64
9017186-6	1997	As shown by CD experiments, helical conformer was induced for NG(28-43) in vesicular solution containing phosphatidyl serine (PS), whereas no helix can be discerned for the peptide in phosphatidyl choline (PC)-containing vesicular solution.	Phosphatidylserines	126-128	neurogranin	Homo sapiens	62-64
9063752-3	1997	In this study we have identified two common structural mutations at codons 316 and 306 in the fifth domain of apoH which rendered apoH unable to bind to negatively charged phosphatidylserine (PS).	Phosphatidylserines	172-190	apolipoprotein H	Homo sapiens	110-114
9063752-3	1997	In this study we have identified two common structural mutations at codons 316 and 306 in the fifth domain of apoH which rendered apoH unable to bind to negatively charged phosphatidylserine (PS).	Phosphatidylserines	172-190	apolipoprotein H	Homo sapiens	130-134
9063752-3	1997	In this study we have identified two common structural mutations at codons 316 and 306 in the fifth domain of apoH which rendered apoH unable to bind to negatively charged phosphatidylserine (PS).	Phosphatidylserines	192-194	apolipoprotein H	Homo sapiens	110-114
9063752-3	1997	In this study we have identified two common structural mutations at codons 316 and 306 in the fifth domain of apoH which rendered apoH unable to bind to negatively charged phosphatidylserine (PS).	Phosphatidylserines	192-194	apolipoprotein H	Homo sapiens	130-134
9138443-5	1997	RESULTS: Illustrations of how certain plasma proteins beta 2 glycoprotein I, prothrombin, high and low molecular weight kininogens interact with the anionic phospholipids cardiolipin and phosphatidylserine and the zwitterionic phospholipid, phosphatidylethanolamine are shown and discussed.	Phosphatidylserines	187-205	coagulation factor II, thrombin	Homo sapiens	77-88
9553941-7	1997	The electrokinetic data for PS and PC liposomes are in good agreement with the modified theory and correlate well with the Gd3+ association constants of 5.10(4) and 10(3) M-1, respectively.	Phosphatidylserines	28-30	GRDX	Homo sapiens	123-126
9553941-9	1997	The dependence of this component on the number of binding sites occupied by cation was shown to be nonlinear but cooperative with the step-like increase of dipole potential up to about 140 mV (positive inside the membrane) at the Gd3+ concentration around the zero charge point of the PS membranes.	Phosphatidylserines	285-287	GRDX	Homo sapiens	230-233
9007991-5	1997	As monitored by anti-factor IX:Ca (II)-specific antibodies and by the quenching of intrinsic fluorescence, all these factor IX species underwent the Ca(II)-induced conformational transition required for phospholipid membrane binding and bound equivalently to phospholipid vesicles composed of phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine.	Phosphatidylserines	293-311	carbonic anhydrase 2	Homo sapiens	149-155
8940195-8	1996	The appearance of similarly slower migrating and more acidic PKC-alpha forms is reproduced upon in vitro autophosphorylation in the presence of phosphatidylserine and phorbol ester, but not in the presence of calcium.	Phosphatidylserines	144-162	protein kinase C, alpha	Rattus norvegicus	61-70
8988331-0	1996	Phosphatidylserine directs differential phosphorylation of actin and glyceraldehyde-3-phosphate dehydrogenase by protein kinase C: possible implications for regulation of actin polymerization.	Phosphatidylserines	0-18	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	69-109
8938187-2	1996	After incorporation into the outer membrane leaflet spin-labeled aminophospholipids phosphatidylserine (PS) and phosphatidylethanolamine (PE) moved rapidly to the inner monolayer, whereas the analog of phosphatidylcholine (PC) disappeared more slowly from the outer leaflet.	Phosphatidylserines	84-102	spindlin 1	Homo sapiens	52-56
8938187-2	1996	After incorporation into the outer membrane leaflet spin-labeled aminophospholipids phosphatidylserine (PS) and phosphatidylethanolamine (PE) moved rapidly to the inner monolayer, whereas the analog of phosphatidylcholine (PC) disappeared more slowly from the outer leaflet.	Phosphatidylserines	104-106	spindlin 1	Homo sapiens	52-56
9022298-4	1996	The addition of vesicles to phosphatidic acid, phosphatidylglycerol and phosphatidylserine reduced the excretion of beta-lactamase whereas vesicles of phosphatidylethanolamine and phosphatidylcholine decreased or increased the excretion of beta-lactamase in dependence on the individual fatty acid residues of the added phospholipids.	Phosphatidylserines	72-90	beta-lactamase	Escherichia coli	116-130
9022298-4	1996	The addition of vesicles to phosphatidic acid, phosphatidylglycerol and phosphatidylserine reduced the excretion of beta-lactamase whereas vesicles of phosphatidylethanolamine and phosphatidylcholine decreased or increased the excretion of beta-lactamase in dependence on the individual fatty acid residues of the added phospholipids.	Phosphatidylserines	72-90	beta-lactamase	Escherichia coli	240-254
8901526-2	1996	We used ellipsometry to study the binding of beta 2GPI and the beta 2GPI-mediated binding of ACA to planar membranes composed of phosphatidylcholine (PC) and 5-20 mol % phosphatidylserine (PS).	Phosphatidylserines	169-187	apolipoprotein H	Homo sapiens	63-72
8898920-2	1996	After PCD was induced in K562 cells, analysis of phospholipid composition, fatty acids and cholesterol content in their membranes showed a decrease in phosphatidylethanolamine and an increase in phosphatidylserine, cardiolipin and phosphatidic acid.	Phosphatidylserines	195-213	dynein axonemal heavy chain 5	Homo sapiens	6-9
8814297-0	1996	Identification of a novel, Ca(2+)-dependent phospholipase D with preference for phosphatidylserine and phosphatidylethanolamine in Saccharomyces cerevisiae.	Phosphatidylserines	80-98	phospholipase D	Saccharomyces cerevisiae S288C	44-59
8809050-4	1996	Furthermore the DGK activity of the wild-type DGK and that expressed by the C4 domain were similarly activated by anionic amphiphiles such as phosphatidylserine, phosphatidylinositol and deoxycholate.	Phosphatidylserines	142-160	diacylglycerol kinase beta	Homo sapiens	16-19
8809050-4	1996	Furthermore the DGK activity of the wild-type DGK and that expressed by the C4 domain were similarly activated by anionic amphiphiles such as phosphatidylserine, phosphatidylinositol and deoxycholate.	Phosphatidylserines	142-160	diacylglycerol kinase beta	Homo sapiens	46-49
8781447-2	1996	We developed a flow-cytometric assay to measure exposure of PS on the outer face of the erythrocyte membrane based on addition of fluorescein-annexin V to whole-blood specimens.	Phosphatidylserines	60-62	annexin A5	Homo sapiens	142-151
8902635-7	1996	Ca(2+)-dependent phospholipid binding assaying of recombinant fusion proteins revealed that the single C2A domain, but not the C2B domain, of Doc2 beta binds phosphatidycholine and phosphatidylserine (2.5:1, w/w) liposomes.	Phosphatidylserines	181-199	double C2 domain beta	Homo sapiens	142-151
8882979-6	1996	The enhanced phosphorylation of annexin I by GT1b was also dependent on PS and Ca2+.	Phosphatidylserines	72-74	annexin A1	Bos taurus	32-41
8882979-9	1996	These results suggest that an enzyme or enzymes other than protein kinase C, epidermal growth factor receptor kinase, or insulin receptor kinase is responsible for the GT1b- and GD3-enhanced phosphorylation of annexin I in the presence of PS and Ca2+.	Phosphatidylserines	239-241	annexin A1	Bos taurus	210-219
8710867-10	1996	Since phosphatidylserine is a common ligand, we expect its binding site to be located in regions where the structures of the Raf-1 and PKC domains are similar.	Phosphatidylserines	6-24	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	125-130
8888119-9	1996	However, the thrombin-induced PA production was temporally associated with a decreased 3H-labelling in PI, but not in PC, PS and PE.	Phosphatidylserines	122-124	coagulation factor II, thrombin	Homo sapiens	13-21
8713056-1	1996	Phosphatidylserine was exposed on the surface of human umbilical endothelial cells (ECV304) a few minutes after adding thrombin in vitro, as monitored by prothrombinase assays with and without annexin V.	Phosphatidylserines	0-18	coagulation factor II, thrombin	Homo sapiens	119-127
8713056-1	1996	Phosphatidylserine was exposed on the surface of human umbilical endothelial cells (ECV304) a few minutes after adding thrombin in vitro, as monitored by prothrombinase assays with and without annexin V.	Phosphatidylserines	0-18	annexin A5	Homo sapiens	193-202
8713089-9	1996	The LPA activation of PKC was dependent on the presence of DAG, PS and Ca2+.	Phosphatidylserines	64-66	protein kinase C alpha	Homo sapiens	22-25
8663221-1	1996	Blood coagulation factor Xa (FXa) has recently been shown to function as a plasminogen receptor in the presence of procoagulant phospholipid (phosphatidylserine; PS) and Ca2+.	Phosphatidylserines	142-160	coagulation factor X	Homo sapiens	18-27
8663221-1	1996	Blood coagulation factor Xa (FXa) has recently been shown to function as a plasminogen receptor in the presence of procoagulant phospholipid (phosphatidylserine; PS) and Ca2+.	Phosphatidylserines	142-160	coagulation factor X	Homo sapiens	29-32
8663012-6	1996	Since B-Raf contains a cysteine-rich domain originally found in protein kinase C as a domain responsible for interaction with phosphatidylserine (PS) and diacylglycerol or 12-O-tetradecanoylphorbol-13-acetate, we have examined here the effect of these compounds on the Ki-Ras-, Ha-Ras-, and Rap1B-induced activation of bovine brain B-Raf.	Phosphatidylserines	126-144	B-Raf proto-oncogene, serine/threonine kinase	Bos taurus	6-11
8663012-6	1996	Since B-Raf contains a cysteine-rich domain originally found in protein kinase C as a domain responsible for interaction with phosphatidylserine (PS) and diacylglycerol or 12-O-tetradecanoylphorbol-13-acetate, we have examined here the effect of these compounds on the Ki-Ras-, Ha-Ras-, and Rap1B-induced activation of bovine brain B-Raf.	Phosphatidylserines	126-144	ras-related protein Rap-1b	Bos taurus	291-296
8663012-6	1996	Since B-Raf contains a cysteine-rich domain originally found in protein kinase C as a domain responsible for interaction with phosphatidylserine (PS) and diacylglycerol or 12-O-tetradecanoylphorbol-13-acetate, we have examined here the effect of these compounds on the Ki-Ras-, Ha-Ras-, and Rap1B-induced activation of bovine brain B-Raf.	Phosphatidylserines	126-144	B-Raf proto-oncogene, serine/threonine kinase	Bos taurus	332-337
8663012-6	1996	Since B-Raf contains a cysteine-rich domain originally found in protein kinase C as a domain responsible for interaction with phosphatidylserine (PS) and diacylglycerol or 12-O-tetradecanoylphorbol-13-acetate, we have examined here the effect of these compounds on the Ki-Ras-, Ha-Ras-, and Rap1B-induced activation of bovine brain B-Raf.	Phosphatidylserines	146-148	B-Raf proto-oncogene, serine/threonine kinase	Bos taurus	6-11
8663012-6	1996	Since B-Raf contains a cysteine-rich domain originally found in protein kinase C as a domain responsible for interaction with phosphatidylserine (PS) and diacylglycerol or 12-O-tetradecanoylphorbol-13-acetate, we have examined here the effect of these compounds on the Ki-Ras-, Ha-Ras-, and Rap1B-induced activation of bovine brain B-Raf.	Phosphatidylserines	146-148	ras-related protein Rap-1b	Bos taurus	291-296
8663012-6	1996	Since B-Raf contains a cysteine-rich domain originally found in protein kinase C as a domain responsible for interaction with phosphatidylserine (PS) and diacylglycerol or 12-O-tetradecanoylphorbol-13-acetate, we have examined here the effect of these compounds on the Ki-Ras-, Ha-Ras-, and Rap1B-induced activation of bovine brain B-Raf.	Phosphatidylserines	146-148	B-Raf proto-oncogene, serine/threonine kinase	Bos taurus	332-337
8663012-9	1996	However, none of the above phospholipids affected the Ha-Ras-stimulated B-Raf activity, whereas PI, PS, phosphatidylethanolamine, and phosphatidic acid inhibited the Rap1B-stimulated B-Raf activity.	Phosphatidylserines	100-102	ras-related protein Rap-1b	Bos taurus	166-171
8663012-11	1996	Synthetic PS with two unsaturated fatty acids, such as 1,2-dioleoyl-PS or 1,2-dilinoleoyl-PS, showed the same effect toward the Ki-Ras- and Rap1B-stimulated B-Raf activities, but synthetic PS with two saturated fatty acids, such as 1, 2-distearoyl-PS, was inactive.	Phosphatidylserines	10-12	ras-related protein Rap-1b	Bos taurus	140-145
8663012-11	1996	Synthetic PS with two unsaturated fatty acids, such as 1,2-dioleoyl-PS or 1,2-dilinoleoyl-PS, showed the same effect toward the Ki-Ras- and Rap1B-stimulated B-Raf activities, but synthetic PS with two saturated fatty acids, such as 1, 2-distearoyl-PS, was inactive.	Phosphatidylserines	10-12	B-Raf proto-oncogene, serine/threonine kinase	Bos taurus	157-162
8663012-11	1996	Synthetic PS with two unsaturated fatty acids, such as 1,2-dioleoyl-PS or 1,2-dilinoleoyl-PS, showed the same effect toward the Ki-Ras- and Rap1B-stimulated B-Raf activities, but synthetic PS with two saturated fatty acids, such as 1, 2-distearoyl-PS, was inactive.	Phosphatidylserines	68-70	ras-related protein Rap-1b	Bos taurus	140-145
8663012-11	1996	Synthetic PS with two unsaturated fatty acids, such as 1,2-dioleoyl-PS or 1,2-dilinoleoyl-PS, showed the same effect toward the Ki-Ras- and Rap1B-stimulated B-Raf activities, but synthetic PS with two saturated fatty acids, such as 1, 2-distearoyl-PS, was inactive.	Phosphatidylserines	68-70	B-Raf proto-oncogene, serine/threonine kinase	Bos taurus	157-162
8652526-2	1996	Here we report the effect of short-chain phosphatidylserine (dicaproylphosphatidylserine, C6PS) and the corresponding phosphatidylglycerol (C6PG) and phosphatidylcholine (C6PC) derivatives on the rate of prothrombin activation by factor Xa.	Phosphatidylserines	41-59	coagulation factor II, thrombin	Homo sapiens	204-215
8652526-2	1996	Here we report the effect of short-chain phosphatidylserine (dicaproylphosphatidylserine, C6PS) and the corresponding phosphatidylglycerol (C6PG) and phosphatidylcholine (C6PC) derivatives on the rate of prothrombin activation by factor Xa.	Phosphatidylserines	41-59	coagulation factor X	Homo sapiens	230-239
8725662-2	1996	This process can be monitored for suspended cell types by using annexin V-FITC, which is a Ca(2+)-dependent, phospholipid-binding protein with high affinity for PS, and flow cytometry.	Phosphatidylserines	161-163	annexin A5	Homo sapiens	64-73
8652596-3	1996	Prothrombinase activities measured at the beginning of the incubation period indicated that approximately 0.06% of PS was located at the outer layer of the red cell membrane, whereas in DMPC-induced vesicles approximately 1.5% the PS was exposed on the outside.	Phosphatidylserines	115-117	coagulation factor X	Homo sapiens	0-14
8652596-3	1996	Prothrombinase activities measured at the beginning of the incubation period indicated that approximately 0.06% of PS was located at the outer layer of the red cell membrane, whereas in DMPC-induced vesicles approximately 1.5% the PS was exposed on the outside.	Phosphatidylserines	231-233	coagulation factor X	Homo sapiens	0-14
8645147-2	1996	Here we demonstrate by two independent methods that Akt-1 from L6 myotubes binds to PtdIns(3,4,5)P3, PtdIns(3,4)P2 and PtdIns(4,5)P2 when presented against a background of phosphatidylserine (PtdSer) or a 1:1 mixture of PtdSer and phosphatidylcholine (PtdCho).	Phosphatidylserines	172-190	AKT serine/threonine kinase 1	Homo sapiens	52-57
8792334-1	1996	The microtubule-associated protein (MAP) 1 preparation, MAP1A and 1B, obtained from rat brain microtubules was associated with protein kinases that were insensitive to cAMP, cGMP, calcium, calcium/calmodulin and calcium/phosphatidylserine.	Phosphatidylserines	220-238	kininogen 2	Rattus norvegicus	4-42
8792334-1	1996	The microtubule-associated protein (MAP) 1 preparation, MAP1A and 1B, obtained from rat brain microtubules was associated with protein kinases that were insensitive to cAMP, cGMP, calcium, calcium/calmodulin and calcium/phosphatidylserine.	Phosphatidylserines	220-238	microtubule-associated protein 1A	Rattus norvegicus	56-68
8725726-2	1996	TFPI was shown to bind calcium-independently to an acidic phospholipid surface composed of phosphatidylserine, but not a surface composed of the neutral phosphatidylcholine.	Phosphatidylserines	91-109	tissue factor pathway inhibitor	Homo sapiens	0-4
8626542-4	1996	The Ca2+-dependent interaction of the C2A domain of synaptotagmin IV with PS was found to have two components with EC50 values of approximately 5 and 120 microM free Ca2+ and exhibited positive cooperativity (Hill coefficient of approximately 2 for both components).	Phosphatidylserines	74-76	synaptotagmin 4	Homo sapiens	52-68
8626542-7	1996	In addition, the C2A domain of synaptotagmin IV cannot bind liposomes consisting of PS (or PI) and phosphatidylcholine, PC (or phosphatidylethanolamine, PE) (1:1, w/w), indicating that the binding to negatively charged phospholipids is inhibited by the presence of PC or PE.	Phosphatidylserines	84-86	synaptotagmin 4	Homo sapiens	31-47
8626548-0	1996	Raf-1 kinase possesses distinct binding domains for phosphatidylserine and phosphatidic acid.	Phosphatidylserines	52-70	Raf-1 proto-oncogene, serine/threonine kinase	Canis lupus familiaris	0-5
8626548-2	1996	Previous studies demonstrated that the cysteine-rich amino-terminal domain of Raf-1 kinase interacts selectively with phosphatidylserine (Ghosh, S., Xie, W. Q., Quest, A. F. G., Mabrouk, G. M., Strum, J. C., and Bell, R. M. (1994) J. Biol.	Phosphatidylserines	118-136	Raf-1 proto-oncogene, serine/threonine kinase	Canis lupus familiaris	78-83
8626548-5	1996	Further analysis showed that full-length Raf-1 bound to both phosphatidylserine and phosphatidic acid (PA).	Phosphatidylserines	61-79	Raf-1 proto-oncogene, serine/threonine kinase	Canis lupus familiaris	41-46
11862263-8	1996	Of 13 lipids or combinations of lipids tested, including arachidonic acid and several eicosanoids, only phosphatidylserine and diacylglycerol in the presence of CA(2+) (2.5 mM) increased c-Raf-1 kinase activity significantly.	Phosphatidylserines	104-122	TNF receptor associated factor 3	Homo sapiens	187-194
8670105-7	1996	Calmodulin activates the enzyme 1.5-1.8-fold in the presence of phosphatidylcholine but not in the presence of phosphatidylserine.	Phosphatidylserines	111-129	calmodulin-3	Sus scrofa	0-10
8729117-7	1996	By contrast, increasing the unsaturation of PS decreased the activity of PKC alpha, and to a lesser extent PKC epsilon.	Phosphatidylserines	44-46	protein kinase C alpha	Homo sapiens	73-82
8729117-7	1996	By contrast, increasing the unsaturation of PS decreased the activity of PKC alpha, and to a lesser extent PKC epsilon.	Phosphatidylserines	44-46	protein kinase C epsilon	Homo sapiens	107-118
8611023-3	1996	Preincubation of MARCKS with phosphatidylserine (PS) or phosphatidylglycerol enhanced the phosphorylation; whereas with phosphatidic acid, phosphatidylinositol (PI), phosphatidylinositol-4-phosphate, or phosphatidylinositol-4,5-biphosphate inhibited the phosphorylation of this substrate by PKC.	Phosphatidylserines	29-47	myristoylated alanine rich protein kinase C substrate	Homo sapiens	17-23
8611023-3	1996	Preincubation of MARCKS with phosphatidylserine (PS) or phosphatidylglycerol enhanced the phosphorylation; whereas with phosphatidic acid, phosphatidylinositol (PI), phosphatidylinositol-4-phosphate, or phosphatidylinositol-4,5-biphosphate inhibited the phosphorylation of this substrate by PKC.	Phosphatidylserines	49-51	myristoylated alanine rich protein kinase C substrate	Homo sapiens	17-23
8611023-7	1996	These results suggest that phosphoinositides and PS bind at different residues within the MARCKS PSD, so that the resulting phospholipid/MARCKS complexes are differentially phosphorylated by PKC.	Phosphatidylserines	49-51	myristoylated alanine rich protein kinase C substrate	Homo sapiens	90-96
8611023-7	1996	These results suggest that phosphoinositides and PS bind at different residues within the MARCKS PSD, so that the resulting phospholipid/MARCKS complexes are differentially phosphorylated by PKC.	Phosphatidylserines	49-51	myristoylated alanine rich protein kinase C substrate	Homo sapiens	137-143
8565303-2	1996	First, phosphatidylserine (PS) and phosphatidylinositol were found to suppress Con A-induced mitogenesis of SPC via inhibition of IL-2 production and acquisition of IL-2 reactivity in Con A-stimulated T cells.	Phosphatidylserines	7-25	interleukin 2	Mus musculus	130-134
8565303-2	1996	First, phosphatidylserine (PS) and phosphatidylinositol were found to suppress Con A-induced mitogenesis of SPC via inhibition of IL-2 production and acquisition of IL-2 reactivity in Con A-stimulated T cells.	Phosphatidylserines	7-25	interleukin 2	Mus musculus	165-169
8565303-2	1996	First, phosphatidylserine (PS) and phosphatidylinositol were found to suppress Con A-induced mitogenesis of SPC via inhibition of IL-2 production and acquisition of IL-2 reactivity in Con A-stimulated T cells.	Phosphatidylserines	27-29	interleukin 2	Mus musculus	130-134
8565303-2	1996	First, phosphatidylserine (PS) and phosphatidylinositol were found to suppress Con A-induced mitogenesis of SPC via inhibition of IL-2 production and acquisition of IL-2 reactivity in Con A-stimulated T cells.	Phosphatidylserines	27-29	interleukin 2	Mus musculus	165-169
8547274-6	1996	The conjugate showed the same binding affinity for phosphatidylserine-containing membranes as annexin V.	Phosphatidylserines	51-69	annexin A5	Rattus norvegicus	94-103
8557688-2	1996	Induction of expression of a GAL1 promoter-driven CDS1 gene on a multicopy plasmid in a cds1 null mutant background resulted in synthase activity 10 times that of wild-type cells and an elevation in the apparent initial rate of synthesis of phosphatidylinositol relative to phosphatidylserine.	Phosphatidylserines	274-292	phosphatidate cytidylyltransferase	Saccharomyces cerevisiae S288C	50-54
8825238-9	1996	CPLX-PS was also shown to be a poorer substrate for phospholipase A2 than PS, with Km = 4.63 mM for CPLX-PS and Km = 0.27 mM for PS; and Vmax = 0.029 ml/minute for CPLX-PS and Vmax = 0.066 ml/minute for PS.	Phosphatidylserines	5-7	phospholipase A2 group IB	Homo sapiens	52-68
9015863-4	1996	PKC-mediated phosphorylation of profilin was observed only in the presence of phosphoinositides; phosphatidylserine and diacylglycerol (known activators of PKC) and other lipids, including phosphatidic acid and phosphatidylglycerol phosphate, did not activate the phosphorylation.	Phosphatidylserines	97-115	proline rich transmembrane protein 2	Homo sapiens	0-3
8549773-2	1995	We report here that cAMP activates Ca(2+)-dependent aggregation of both phosphatidylserine (PS) liposomes and bovine chromaffin granules driven by [des 1-12]annexin I (lipocortin I, Anx1).	Phosphatidylserines	72-90	annexin A1	Bos taurus	157-166
8549773-2	1995	We report here that cAMP activates Ca(2+)-dependent aggregation of both phosphatidylserine (PS) liposomes and bovine chromaffin granules driven by [des 1-12]annexin I (lipocortin I, Anx1).	Phosphatidylserines	72-90	annexin A1	Bos taurus	168-180
8519761-1	1995	Previously, we showed that myosin II heavy chains bind to phosphatidylserine (PS) liposomes via their COOH terminal regions and that protein kinase C (PK C) phosphorylates the PS-bound heavy chains [Murakami et al.	Phosphatidylserines	58-76	myosin heavy chain 14	Homo sapiens	27-33
8519761-1	1995	Previously, we showed that myosin II heavy chains bind to phosphatidylserine (PS) liposomes via their COOH terminal regions and that protein kinase C (PK C) phosphorylates the PS-bound heavy chains [Murakami et al.	Phosphatidylserines	58-76	proline rich transmembrane protein 2	Homo sapiens	151-155
8519761-9	1995	A similar level of PS was required for phosphorylation of fragments by PK C, indicating that binding of tail regions to PS is a prerequisite for phosphorylation by PK C.	Phosphatidylserines	19-21	proline rich transmembrane protein 2	Homo sapiens	71-75
8519761-9	1995	A similar level of PS was required for phosphorylation of fragments by PK C, indicating that binding of tail regions to PS is a prerequisite for phosphorylation by PK C.	Phosphatidylserines	120-122	proline rich transmembrane protein 2	Homo sapiens	71-75
8519761-9	1995	A similar level of PS was required for phosphorylation of fragments by PK C, indicating that binding of tail regions to PS is a prerequisite for phosphorylation by PK C.	Phosphatidylserines	120-122	proline rich transmembrane protein 2	Homo sapiens	164-168
7493920-6	1995	In addition, using solid phase phospholipid binding assays we demonstrate that FGF-1 is able to specifically associate with phosphatidylserine (PS).	Phosphatidylserines	124-142	fibroblast growth factor 1	Homo sapiens	79-84
7493929-2	1995	A monoclonal anti-idiotypic antibody, Id8F7, previously shown to bind to a phosphatidylserine (PS)-specific binding site on protein kinase C (PKC) has been used to identify a 12-amino acid consensus sequence shared by PKC and phosphatidylserine decarboxylase (PSD).	Phosphatidylserines	75-93	protein kinase C, gamma	Rattus norvegicus	142-145
7493929-2	1995	A monoclonal anti-idiotypic antibody, Id8F7, previously shown to bind to a phosphatidylserine (PS)-specific binding site on protein kinase C (PKC) has been used to identify a 12-amino acid consensus sequence shared by PKC and phosphatidylserine decarboxylase (PSD).	Phosphatidylserines	75-93	protein kinase C, gamma	Rattus norvegicus	218-221
7493929-2	1995	A monoclonal anti-idiotypic antibody, Id8F7, previously shown to bind to a phosphatidylserine (PS)-specific binding site on protein kinase C (PKC) has been used to identify a 12-amino acid consensus sequence shared by PKC and phosphatidylserine decarboxylase (PSD).	Phosphatidylserines	95-97	protein kinase C, gamma	Rattus norvegicus	142-145
7493929-2	1995	A monoclonal anti-idiotypic antibody, Id8F7, previously shown to bind to a phosphatidylserine (PS)-specific binding site on protein kinase C (PKC) has been used to identify a 12-amino acid consensus sequence shared by PKC and phosphatidylserine decarboxylase (PSD).	Phosphatidylserines	95-97	protein kinase C, gamma	Rattus norvegicus	218-221
7493929-5	1995	The results suggest that the conserved amino acid residues represent a basic structural motif for the specific interaction with PS, and the corresponding regions of PKC and PSD form the PS-specific binding sites of these enzymes.	Phosphatidylserines	128-130	protein kinase C, gamma	Rattus norvegicus	165-168
7493929-5	1995	The results suggest that the conserved amino acid residues represent a basic structural motif for the specific interaction with PS, and the corresponding regions of PKC and PSD form the PS-specific binding sites of these enzymes.	Phosphatidylserines	173-175	protein kinase C, gamma	Rattus norvegicus	165-168
7585518-1	1995	1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) is a synthetic diether phospholipid that is competitive with phosphatidylserine binding to the regulatory domain of protein kinase C (PKC).	Phosphatidylserines	128-146	proline rich transmembrane protein 2	Homo sapiens	183-199
7585518-1	1995	1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) is a synthetic diether phospholipid that is competitive with phosphatidylserine binding to the regulatory domain of protein kinase C (PKC).	Phosphatidylserines	128-146	proline rich transmembrane protein 2	Homo sapiens	201-204
8593251-4	1995	Lysophosphatidic acids (LPAs) and phosphatidylserines (PSs) also induced PDE4 activation, whereas phosphatidylcholines (PCs), phosphatidylethanolamines (PEs) and diacylglycerol did not.	Phosphatidylserines	34-53	phosphodiesterase 4A	Homo sapiens	73-77
8593251-4	1995	Lysophosphatidic acids (LPAs) and phosphatidylserines (PSs) also induced PDE4 activation, whereas phosphatidylcholines (PCs), phosphatidylethanolamines (PEs) and diacylglycerol did not.	Phosphatidylserines	55-58	phosphodiesterase 4A	Homo sapiens	73-77
7595224-6	1995	We also report that, under conditions in which the morphological features of apoptosis were prevented (macromolecular synthesis inhibition, overexpression of Bcl-2 or Abl), the appearance of PS on the external leaflet of the PM was similarly prevented.	Phosphatidylserines	191-193	BCL2 apoptosis regulator	Homo sapiens	158-163
7595224-6	1995	We also report that, under conditions in which the morphological features of apoptosis were prevented (macromolecular synthesis inhibition, overexpression of Bcl-2 or Abl), the appearance of PS on the external leaflet of the PM was similarly prevented.	Phosphatidylserines	191-193	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	167-170
8656068-2	1995	Among the phospholipids used as emulsifiers, those with a negative charge, such as phosphatidylserine, phosphatidic acid, phosphatidylinositol, and cardiolipin, gave a higher level of hydrolysis by neutral cholesterol esterase than other less negatively charged phospholipids, such as phosphatidylcholine, lysophosphatidylcholine, phosphatidylethanolamine, and sphingomyelin.	Phosphatidylserines	83-101	carboxyl ester lipase	Rattus norvegicus	206-226
8576100-4	1995	IL-1 alpha, but not IL-1 beta, caused an increase in the permeability of liposomes composed of phosphatidylserine (PS), at neutral and acidic pHs, as demonstrated by measuring the efflux of calcein.	Phosphatidylserines	95-113	interleukin 1 alpha	Homo sapiens	0-10
8576100-4	1995	IL-1 alpha, but not IL-1 beta, caused an increase in the permeability of liposomes composed of phosphatidylserine (PS), at neutral and acidic pHs, as demonstrated by measuring the efflux of calcein.	Phosphatidylserines	115-117	interleukin 1 alpha	Homo sapiens	0-10
8560427-8	1995	Annexin V was found to bind to lipid bilayers containing more than 5 mole % PS as estimated by binding of fluorescent-labelled annexin V to liposomes with varying PS concentrations.	Phosphatidylserines	76-78	annexin A5	Homo sapiens	0-9
8560427-8	1995	Annexin V was found to bind to lipid bilayers containing more than 5 mole % PS as estimated by binding of fluorescent-labelled annexin V to liposomes with varying PS concentrations.	Phosphatidylserines	163-165	annexin A5	Homo sapiens	0-9
7547927-8	1995	Farnesylation of the nonmethylated K-Ras 4B peptide enhances its affinity to vesicles containing acidic phospholipids (phosphatidylglycerol or phosphatidylserine) by 70-fold, and methylation leads to an additional dramatic (150-fold) increase in membrane affinity.	Phosphatidylserines	143-161	KRAS proto-oncogene, GTPase	Homo sapiens	35-43
7654192-0	1995	Binding of blood coagulation factor VIII and its light chain to phosphatidylserine/phosphatidylcholine bilayers as measured by ellipsometry.	Phosphatidylserines	64-82	cytochrome c oxidase subunit 8A	Homo sapiens	36-40
7544643-1	1995	The finding that human factor VIII (fVIII) inhibitor antibodies with C2 domain epitopes interfere with the binding of fVIII to phosphatidylserine (PS) suggested that this is the mechanism by which they inactivate fVIII.	Phosphatidylserines	127-145	coagulation factor VIII	Homo sapiens	23-34
7544643-1	1995	The finding that human factor VIII (fVIII) inhibitor antibodies with C2 domain epitopes interfere with the binding of fVIII to phosphatidylserine (PS) suggested that this is the mechanism by which they inactivate fVIII.	Phosphatidylserines	127-145	coagulation factor VIII	Homo sapiens	36-41
7544643-1	1995	The finding that human factor VIII (fVIII) inhibitor antibodies with C2 domain epitopes interfere with the binding of fVIII to phosphatidylserine (PS) suggested that this is the mechanism by which they inactivate fVIII.	Phosphatidylserines	127-145	coagulation factor VIII	Homo sapiens	118-123
7544643-1	1995	The finding that human factor VIII (fVIII) inhibitor antibodies with C2 domain epitopes interfere with the binding of fVIII to phosphatidylserine (PS) suggested that this is the mechanism by which they inactivate fVIII.	Phosphatidylserines	127-145	coagulation factor VIII	Homo sapiens	118-123
7544643-8	1995	These antibodies also inhibited the binding of fVIII to synthetic phospholipid membranes of PS and phosphatidylcholine, confirming that the blocked epitopes contribute to membrane binding as well as binding to PS.	Phosphatidylserines	92-94	coagulation factor VIII	Homo sapiens	47-52
7544643-10	1995	As the maximal function of activated fVIII in the intrinsic factor Xase complex requires its binding to a phospholipid membrane, we propose that fVIII inhibition by anti-C2 antibodies is related to the overlap of their epitopes with the PS-binding site.	Phosphatidylserines	237-239	coagulation factor VIII	Homo sapiens	37-42
7544643-10	1995	As the maximal function of activated fVIII in the intrinsic factor Xase complex requires its binding to a phospholipid membrane, we propose that fVIII inhibition by anti-C2 antibodies is related to the overlap of their epitopes with the PS-binding site.	Phosphatidylserines	237-239	coagulation factor VIII	Homo sapiens	145-150
7650001-4	1995	The partition coefficient, Kp, describing the affinity of myristoylated MRP for acidic lipid vesicles (20% phosphatidylserine, 80% phosphatidylcholine) is 5-8 x 10(3) M-1, which is only 2-4 times larger than the partition coefficient for the unmyristoylated protein.	Phosphatidylserines	107-125	MARCKS-like 1	Mus musculus	72-75
7481876-5	1995	Digestion of cardiac SR isolated from control rats with phospholipase A2 inhibited 3H-ryanodine binding, which could be dramatically recovered by the incorporation of phosphatidylcholine (PC), or phosphatidylserine (PS), or phosphatidylethanolamine (PE) into the isolated cardiac SR. Incorporation of above phospolipids into SR isolated from septic rats reversed shock-induced inhibition of 3H-ryanodine binding.	Phosphatidylserines	196-214	phospholipase A2 group IB	Rattus norvegicus	56-72
7481876-5	1995	Digestion of cardiac SR isolated from control rats with phospholipase A2 inhibited 3H-ryanodine binding, which could be dramatically recovered by the incorporation of phosphatidylcholine (PC), or phosphatidylserine (PS), or phosphatidylethanolamine (PE) into the isolated cardiac SR. Incorporation of above phospolipids into SR isolated from septic rats reversed shock-induced inhibition of 3H-ryanodine binding.	Phosphatidylserines	216-218	phospholipase A2 group IB	Rattus norvegicus	56-72
7606887-1	1995	Interleukin 1 alpha (IL1 alpha) and tumor necrosis factor alpha (TNF alpha) have been successfully incorporated into specific phosphatidylcholine (PC) and phosphatidylserine (PS) multilamellar vesicle (MLV) liposomes by modifying the concentration of calcium ion and pH of the encapsulation buffer.	Phosphatidylserines	155-173	interleukin 1 alpha	Mus musculus	0-19
7606887-1	1995	Interleukin 1 alpha (IL1 alpha) and tumor necrosis factor alpha (TNF alpha) have been successfully incorporated into specific phosphatidylcholine (PC) and phosphatidylserine (PS) multilamellar vesicle (MLV) liposomes by modifying the concentration of calcium ion and pH of the encapsulation buffer.	Phosphatidylserines	155-173	interleukin 1 alpha	Mus musculus	21-30
7606887-1	1995	Interleukin 1 alpha (IL1 alpha) and tumor necrosis factor alpha (TNF alpha) have been successfully incorporated into specific phosphatidylcholine (PC) and phosphatidylserine (PS) multilamellar vesicle (MLV) liposomes by modifying the concentration of calcium ion and pH of the encapsulation buffer.	Phosphatidylserines	155-173	tumor necrosis factor	Mus musculus	36-63
7606887-1	1995	Interleukin 1 alpha (IL1 alpha) and tumor necrosis factor alpha (TNF alpha) have been successfully incorporated into specific phosphatidylcholine (PC) and phosphatidylserine (PS) multilamellar vesicle (MLV) liposomes by modifying the concentration of calcium ion and pH of the encapsulation buffer.	Phosphatidylserines	155-173	tumor necrosis factor	Mus musculus	65-74
8537301-3	1995	We found that at neutral pH and low ionic strength, beta 2-GPI became bound to liposome membranes containing cardiolipin, phosphatidylglycerol, phosphatidylserine, phosphatidylserine, phosphatidic acid, or phosphatidylinositol, but not phosphatidylcholine alone.	Phosphatidylserines	144-162	apolipoprotein H	Bos taurus	52-62
8537301-3	1995	We found that at neutral pH and low ionic strength, beta 2-GPI became bound to liposome membranes containing cardiolipin, phosphatidylglycerol, phosphatidylserine, phosphatidylserine, phosphatidic acid, or phosphatidylinositol, but not phosphatidylcholine alone.	Phosphatidylserines	164-182	apolipoprotein H	Bos taurus	52-62
7797479-2	1995	Using pure CTP by synthetase as a substrate, protein kinase C activity was dose- and time-dependent and required calcium, diacylglycerol, and phosphatidylserine for full activation.	Phosphatidylserines	142-160	protein kinase C	Saccharomyces cerevisiae S288C	45-61
7775440-5	1995	We have demonstrated, however, that SPIII-T4 is able to inhibit fVIII binding to phosphatidylserine (PS) in a dose-dependent fashion, but only at concentrations higher than those used in previous experiments.	Phosphatidylserines	81-99	coagulation factor VIII	Homo sapiens	64-69
7775440-5	1995	We have demonstrated, however, that SPIII-T4 is able to inhibit fVIII binding to phosphatidylserine (PS) in a dose-dependent fashion, but only at concentrations higher than those used in previous experiments.	Phosphatidylserines	101-103	coagulation factor VIII	Homo sapiens	64-69
7744864-4	1995	In this study, to identify the minimum PS-binding region of MARCKS and the regulatory phosphorylation site, the binding of MARCKS to PS was examined in deletion mutants producing glutathione S-transferase (GST) fusion proteins.	Phosphatidylserines	39-41	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	60-66
7744864-4	1995	In this study, to identify the minimum PS-binding region of MARCKS and the regulatory phosphorylation site, the binding of MARCKS to PS was examined in deletion mutants producing glutathione S-transferase (GST) fusion proteins.	Phosphatidylserines	133-135	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	123-129
7744864-10	1995	These results strongly suggest that MARCKS binds to PS molecules in the inner leaflet of the plasma membrane through residues 127-156, with residues 153-156 (FKKS) being particularly important in the binding of MARCKS to PS, and that the binding is regulated through the protein kinase C-catalyzed phosphorylation of the serine at residue 152.	Phosphatidylserines	52-54	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	36-42
7744864-10	1995	These results strongly suggest that MARCKS binds to PS molecules in the inner leaflet of the plasma membrane through residues 127-156, with residues 153-156 (FKKS) being particularly important in the binding of MARCKS to PS, and that the binding is regulated through the protein kinase C-catalyzed phosphorylation of the serine at residue 152.	Phosphatidylserines	221-223	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	36-42
7744864-10	1995	These results strongly suggest that MARCKS binds to PS molecules in the inner leaflet of the plasma membrane through residues 127-156, with residues 153-156 (FKKS) being particularly important in the binding of MARCKS to PS, and that the binding is regulated through the protein kinase C-catalyzed phosphorylation of the serine at residue 152.	Phosphatidylserines	221-223	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	211-217
7604972-8	1995	Thus, LC1 appears to be a candidate for several putative activities in apoptosis (e.g., phagocyte recognition via phosphatidylserine binding and/or buffering intracellular Ca++) in addition to its anti-inflammatory role.	Phosphatidylserines	114-132	annexin A1	Homo sapiens	6-9
7627125-4	1995	Purified p35 had other annexin like characters such as strongly bind to phosphatidylserine and phosphatidylinositol, phospholipase A2 inhibition and liposome aggregation.	Phosphatidylserines	72-90	interleukin 12A	Homo sapiens	9-12
7890740-13	1995	Strains containing both the psd1-delta 1::TRP1 and psd2-delta 1::HIS3 null alleles, however, express no detectable PSD activity, are ethanolamine auxotrophs and show a severe deficit in the conversion of [3H]serine-labeled phosphatidylserine to phosphatidylethanolamine.	Phosphatidylserines	223-241	phosphatidylserine decarboxylase 1	Saccharomyces cerevisiae S288C	28-32
7890740-13	1995	Strains containing both the psd1-delta 1::TRP1 and psd2-delta 1::HIS3 null alleles, however, express no detectable PSD activity, are ethanolamine auxotrophs and show a severe deficit in the conversion of [3H]serine-labeled phosphatidylserine to phosphatidylethanolamine.	Phosphatidylserines	223-241	phosphatidylserine decarboxylase 2	Saccharomyces cerevisiae S288C	51-63
7890702-7	1995	Furthermore, both PS and phosphatidylinositol 4,5-bisphosphate specifically bound to beta ARK1, whereas phosphatidylcholine, a lipid that did not modulate beta ARK activity, did not bind to beta ARK1.	Phosphatidylserines	18-20	G protein-coupled receptor kinase 2	Homo sapiens	85-94
7890702-7	1995	Furthermore, both PS and phosphatidylinositol 4,5-bisphosphate specifically bound to beta ARK1, whereas phosphatidylcholine, a lipid that did not modulate beta ARK activity, did not bind to beta ARK1.	Phosphatidylserines	18-20	G protein-coupled receptor kinase 2	Homo sapiens	190-199
7533539-3	1995	All cationic PKC substrates tested, neurogranin peptide analog, neurogranin, and histone III-S, formed aggregates with PS/DG/NP-40/Ca2+ mixed micelles in a time-dependent fashion.	Phosphatidylserines	119-121	protein kinase C alpha	Homo sapiens	13-16
7533539-3	1995	All cationic PKC substrates tested, neurogranin peptide analog, neurogranin, and histone III-S, formed aggregates with PS/DG/NP-40/Ca2+ mixed micelles in a time-dependent fashion.	Phosphatidylserines	119-121	neurogranin	Homo sapiens	36-47
7533539-3	1995	All cationic PKC substrates tested, neurogranin peptide analog, neurogranin, and histone III-S, formed aggregates with PS/DG/NP-40/Ca2+ mixed micelles in a time-dependent fashion.	Phosphatidylserines	119-121	neurogranin	Homo sapiens	64-75
7893714-3	1995	The peptide, fVIII2303-24, with a primary structure of TRYLRIHPQSWVHQIALRMEVL, aggregates at concentrations above 2 microM at pH 7 but is soluble at pH 6. fVIII2303-24 competes with fluorescein-labeled factor VIII (Ki = 3 microM) for binding sites on synthetic phosphatidylserine-containing membranes and for binding sites on stimulated platelets.	Phosphatidylserines	261-279	coagulation factor VIII	Homo sapiens	13-18
7756521-1	1995	Ca2+ is known to induce the adhesion and collapse of phosphatidylserine (PS) bilayers into dehydrated multilamellar structures.	Phosphatidylserines	53-71	carbonic anhydrase 2	Bos taurus	0-3
7756521-1	1995	Ca2+ is known to induce the adhesion and collapse of phosphatidylserine (PS) bilayers into dehydrated multilamellar structures.	Phosphatidylserines	73-75	carbonic anhydrase 2	Bos taurus	0-3
7608138-4	1995	We found that a 12-amino acid synthetic peptide corresponding to the third CDR of the heavy chain (amino acid residues 93-102, referred to as CDR3-H) bound specifically to PS.	Phosphatidylserines	172-174	CDR3	Homo sapiens	142-146
7608138-7	1995	The interaction between the CDR3-H peptide and water-soluble PS-derivatives was investigated by inhibition of the ELISA.	Phosphatidylserines	61-63	CDR3	Homo sapiens	28-32
7608138-9	1995	These observations suggest that the CDR3-H peptide plays a major role in the interaction of PS4A7 with the phosphoserine residue of the PS molecule.	Phosphatidylserines	92-94	CDR3	Homo sapiens	36-40
7757108-3	1995	We found that at neutral pH and low ionic strength beta 2-GPI bound to liposome membranes containing cardiolipin with a dissociation constant (Kd) of 10(-8) M. Phosphatidylglycerol, phosphatidylserine, phosphatidic acid or phosphatidylinositol bound to beta 2-GPI, but phosphatidylcholine did not.	Phosphatidylserines	182-200	apolipoprotein H	Bos taurus	51-61
7784893-1	1995	Previous studies have demonstrated that the activation of phospholipase A2 (PLA2) during heat stress would caused disorder of membrane phospholipids metabolism, accompanied by a decrease in phosphatidylcholine and phosphatidyl-serine and an increase in arachidonic acid.	Phosphatidylserines	214-233	phospholipase A2 group IB	Rattus norvegicus	58-74
7784893-1	1995	Previous studies have demonstrated that the activation of phospholipase A2 (PLA2) during heat stress would caused disorder of membrane phospholipids metabolism, accompanied by a decrease in phosphatidylcholine and phosphatidyl-serine and an increase in arachidonic acid.	Phosphatidylserines	214-233	phospholipase A2 group IB	Rattus norvegicus	76-80
7840634-7	1995	CaM and S100 inhibited the PKM-catalyzed phosphorylation of MARCKS only in the presence of Ca2+ and addition of phosphatidylserine (PS)/dioleoylglycerol (DG) did not influence the inhibitory effect.	Phosphatidylserines	112-130	calmodulin 1	Homo sapiens	0-3
7840634-7	1995	CaM and S100 inhibited the PKM-catalyzed phosphorylation of MARCKS only in the presence of Ca2+ and addition of phosphatidylserine (PS)/dioleoylglycerol (DG) did not influence the inhibitory effect.	Phosphatidylserines	112-130	S100 calcium binding protein B	Homo sapiens	8-12
7840634-7	1995	CaM and S100 inhibited the PKM-catalyzed phosphorylation of MARCKS only in the presence of Ca2+ and addition of phosphatidylserine (PS)/dioleoylglycerol (DG) did not influence the inhibitory effect.	Phosphatidylserines	112-130	pyruvate kinase M1/2	Homo sapiens	27-30
7840634-7	1995	CaM and S100 inhibited the PKM-catalyzed phosphorylation of MARCKS only in the presence of Ca2+ and addition of phosphatidylserine (PS)/dioleoylglycerol (DG) did not influence the inhibitory effect.	Phosphatidylserines	112-130	myristoylated alanine rich protein kinase C substrate	Homo sapiens	60-66
7840634-7	1995	CaM and S100 inhibited the PKM-catalyzed phosphorylation of MARCKS only in the presence of Ca2+ and addition of phosphatidylserine (PS)/dioleoylglycerol (DG) did not influence the inhibitory effect.	Phosphatidylserines	132-134	calmodulin 1	Homo sapiens	0-3
7840634-7	1995	CaM and S100 inhibited the PKM-catalyzed phosphorylation of MARCKS only in the presence of Ca2+ and addition of phosphatidylserine (PS)/dioleoylglycerol (DG) did not influence the inhibitory effect.	Phosphatidylserines	132-134	S100 calcium binding protein B	Homo sapiens	8-12
7840634-7	1995	CaM and S100 inhibited the PKM-catalyzed phosphorylation of MARCKS only in the presence of Ca2+ and addition of phosphatidylserine (PS)/dioleoylglycerol (DG) did not influence the inhibitory effect.	Phosphatidylserines	132-134	pyruvate kinase M1/2	Homo sapiens	27-30
7840634-7	1995	CaM and S100 inhibited the PKM-catalyzed phosphorylation of MARCKS only in the presence of Ca2+ and addition of phosphatidylserine (PS)/dioleoylglycerol (DG) did not influence the inhibitory effect.	Phosphatidylserines	132-134	myristoylated alanine rich protein kinase C substrate	Homo sapiens	60-66
7880127-7	1995	Another five of the 20 showed low GPI dependency aCL antibodies; however, three of these patients required GPI for binding to phosphatidylserine, phosphatidylinositol, or both.	Phosphatidylserines	126-144	glucose-6-phosphate isomerase	Homo sapiens	107-110
7728866-7	1995	Increasing the concentration of PS to 40% does result in the binding of BBMI to both vesicles and planar membranes.	Phosphatidylserines	32-34	myosin IA	Homo sapiens	72-76
7728866-11	1995	When membrane fluidity is reduced by adding cholesterol to the membrane lipids containing 40% PS, BBMI still binds to the membrane, but again no actin filament motility is observed.	Phosphatidylserines	94-96	myosin IA	Homo sapiens	98-102
7559741-6	1995	The purified P-glycoprotein was reconstituted by detergent dialysis into liposomes composed of phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine.	Phosphatidylserines	145-163	ATP binding cassette subfamily B member 1	Homo sapiens	13-27
7775393-6	1995	The recombinant p50 was phosphorylated in vitro by rabbit protein kinase C (PKC) and by murine cytosolic protein kinase, that was activated by a combination of phosphatidylserine and diacylglycerol.	Phosphatidylserines	160-178	Y-box-binding protein 1	Oryctolagus cuniculus	16-19
7529505-5	1995	In addition to aa 92-140, PKC-stimulating cofactors (phosphatidylserine, phorbol ester, and Ca2+) are required for inactivation by calphostin C even in the case of PKC mutants that do not require these cofactors for enzymatic activity.	Phosphatidylserines	53-71	protein kinase C alpha	Bos taurus	26-29
7891673-5	1994	The fusion protein obtained cross-reacts with native scinderin antibodies and binds phosphatidylserine (PS), phosphatidylinositol 4,5-bisphosphate (PIP2) and actin in a Ca(+)-dependent manner.	Phosphatidylserines	84-102	scinderin	Bos taurus	53-62
7891673-5	1994	The fusion protein obtained cross-reacts with native scinderin antibodies and binds phosphatidylserine (PS), phosphatidylinositol 4,5-bisphosphate (PIP2) and actin in a Ca(+)-dependent manner.	Phosphatidylserines	104-106	scinderin	Bos taurus	53-62
7527558-3	1994	Specifically, c-Src was shown to bind 2500-fold more strongly to vesicles composed of the physiological ratio of 2:1 phosphatidylcholine (PC)/phosphatidylserine (PS) than to neutral PC bilayer vesicles.	Phosphatidylserines	142-160	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	14-19
7527558-3	1994	Specifically, c-Src was shown to bind 2500-fold more strongly to vesicles composed of the physiological ratio of 2:1 phosphatidylcholine (PC)/phosphatidylserine (PS) than to neutral PC bilayer vesicles.	Phosphatidylserines	162-164	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	14-19
7527558-6	1994	The transforming v-Src and activated c-Src (Y527F) proteins also bound more strongly to PC/PS bilayers (apparent Kd of approximately 1 x 10(-5) M) than to neutral PC bilayers.	Phosphatidylserines	91-93	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	19-22
7527558-6	1994	The transforming v-Src and activated c-Src (Y527F) proteins also bound more strongly to PC/PS bilayers (apparent Kd of approximately 1 x 10(-5) M) than to neutral PC bilayers.	Phosphatidylserines	91-93	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	37-42
7737682-5	1994	Liposomes composed of PS may down-modulate macrophage anti-leishmanial activities, suppress macrophage TNF production, suppress lymphocyte proliferation, and increase macrophage proliferation.	Phosphatidylserines	22-24	tumor necrosis factor	Homo sapiens	103-106
7534315-5	1994	Extracts prepared from alpha 1-chimaerin-expressing cells showed rac-1 GAP activity that was regulated by phosphatidylserine and phorbol ester.	Phosphatidylserines	106-124	chimerin 1	Mus musculus	23-40
7534315-5	1994	Extracts prepared from alpha 1-chimaerin-expressing cells showed rac-1 GAP activity that was regulated by phosphatidylserine and phorbol ester.	Phosphatidylserines	106-124	Rac family small GTPase 1	Mus musculus	65-70
7999065-5	1994	These results indicate that Rabphilin-3A binds to beta-adducin in the presence of Ca2+ and phosphatidylserine.	Phosphatidylserines	91-109	rabphilin 3A	Bos taurus	28-40
7999065-5	1994	These results indicate that Rabphilin-3A binds to beta-adducin in the presence of Ca2+ and phosphatidylserine.	Phosphatidylserines	91-109	adducin 2	Bos taurus	50-62
7961831-2	1994	Incorporation of 32Pi into phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine in wild type and ept1 strains was decreased in the presence of exogenous inositol.	Phosphatidylserines	78-96	bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase	Saccharomyces cerevisiae S288C	114-118
7971987-3	1994	When reincorporated into artificial bilayers formed from phosphatidylcholine, it was able to transport a spin-labeled phosphatidylserine analogue from the inner to the outer membrane leaflet provided Mg2+ ATP was present in the incubation mixture.	Phosphatidylserines	118-136	mucin 7, secreted	Homo sapiens	200-203
7931347-1	1994	Annexin VI bound to &gt; 14 species of proteins in the whole homogenate of rat forebrain in a Ca2+/phosphatidylserine- or phosphatidic acid-dependent manner.	Phosphatidylserines	99-117	annexin A6	Rattus norvegicus	0-10
7853148-5	1994	Phosphatidylserine is synthesized by the two kinds of base-exchange enzymes, namely serine-exchange enzyme I and II, through the chain reactions in participation of phosphatidylserine decarboxylase; phosphatidylcholine--&gt;phosphatidylserine--&gt;phosphatidylethanolamine--&gt; phosphatidylserine.	Phosphatidylserines	0-18	phosphatidylserine synthase 1	Homo sapiens	84-115
7853148-5	1994	Phosphatidylserine is synthesized by the two kinds of base-exchange enzymes, namely serine-exchange enzyme I and II, through the chain reactions in participation of phosphatidylserine decarboxylase; phosphatidylcholine--&gt;phosphatidylserine--&gt;phosphatidylethanolamine--&gt; phosphatidylserine.	Phosphatidylserines	165-183	phosphatidylserine synthase 1	Homo sapiens	84-115
7853148-5	1994	Phosphatidylserine is synthesized by the two kinds of base-exchange enzymes, namely serine-exchange enzyme I and II, through the chain reactions in participation of phosphatidylserine decarboxylase; phosphatidylcholine--&gt;phosphatidylserine--&gt;phosphatidylethanolamine--&gt; phosphatidylserine.	Phosphatidylserines	224-242	phosphatidylserine synthase 1	Homo sapiens	84-115
7929289-1	1994	Prothrombinase assembly takes place on the surface of unsaturated phosphatidylcholine (PC), phosphatidylserine (PS) membranes in the presence of Ca2+, through the rapid association of membrane-bound factor Va and factor Xa.	Phosphatidylserines	92-110	coagulation factor X	Homo sapiens	0-14
7929289-1	1994	Prothrombinase assembly takes place on the surface of unsaturated phosphatidylcholine (PC), phosphatidylserine (PS) membranes in the presence of Ca2+, through the rapid association of membrane-bound factor Va and factor Xa.	Phosphatidylserines	112-114	coagulation factor X	Homo sapiens	0-14
7819508-1	1994	Previous work has shown that bovine prothrombin fragment 1 binds to substrate-supported planar membranes composed of phosphatidylcholine (PC) and phosphatidylserine (PS) in a Ca(2+)-specific manner.	Phosphatidylserines	146-164	coagulation factor II, thrombin	Bos taurus	36-47
7819508-1	1994	Previous work has shown that bovine prothrombin fragment 1 binds to substrate-supported planar membranes composed of phosphatidylcholine (PC) and phosphatidylserine (PS) in a Ca(2+)-specific manner.	Phosphatidylserines	166-168	coagulation factor II, thrombin	Bos taurus	36-47
7522256-4	1994	Phosphatidylserine is an essential anionic phospholipid for surface amplification of thrombin generation.	Phosphatidylserines	0-18	coagulation factor II, thrombin	Homo sapiens	85-93
8001180-5	1994	The lipid mixtures sufficient to yield full photochemical function of rhodopsin include a native-like head group composition, viz, comprising phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS), in combination with polyunsaturated docosahexaenoic acid (DHA; 22:6 omega 3) chains.	Phosphatidylserines	223-225	rhodopsin	Homo sapiens	70-79
7811947-16	1994	These rest suggest that 1) protein 4.1 binds to membrane or submembrane sites at least in part reversibly ; 2) the most reversible sites are probably not proteinaceous and not glycophorin C, but possibly are phospholipids (especially phosphatidylserine); and 3) TIWRFRAP can successfully examine the fast reversible dynamics of cytoskeletal components binding to biological membranes.	Phosphatidylserines	234-252	erythrocyte membrane protein band 4.1	Homo sapiens	27-38
7819131-0	1994	Cholesterol sulfate, a novel activator for the eta isoform of protein kinase C. Activity of protein kinase C depends on the interaction with polar head-groups of two membrane lipids, i.e., phosphatidylserine and diacylglycerol.	Phosphatidylserines	189-207	endothelin receptor type A	Homo sapiens	47-50
8074672-1	1994	The purified preparation showed typical characteristics of the conventional type of mammalian PKC that responds to Ca2+, phosphatidylserine, and diacylglycerol or the tumor-promoting phorbol ester, phorbol 12-myristate 13-acetate.	Phosphatidylserines	121-139	proline rich transmembrane protein 2	Homo sapiens	94-97
8063727-7	1994	This portion of twitchin (residues 5890-6268) was also phosphorylated in vitro by protein kinase C in the absence of calcium and phosphotidylserine, but not by cAMP-dependent protein kinase.	Phosphatidylserines	129-147	Twitchin	Caenorhabditis elegans	16-24
7980847-2	1994	Immunization of naive mice with beta-2-GPI resulted in elevated levels of antibodies directed against negatively charged phospholipids (cardiolipin, phosphotidylserine, phosphatidylinositol).	Phosphatidylserines	149-167	apolipoprotein H	Mus musculus	32-42
8026579-1	1994	Null cho1 mutants of Saccharomyces cerevisiae are incapable of phosphatidyl-serine synthesis.	Phosphatidylserines	63-82	CDP-diacylglycerol-serine O-phosphatidyltransferase	Saccharomyces cerevisiae S288C	5-9
8042784-5	1994	RESULTS: Both halothane (50% effective concentration = 2.2 vol%) and propofol (50% effective concentration = 240 microM) markedly stimulated histone H1 phosphorylation by PKC in the presence of a lipid vesicle preparation consisting of phosphatidylcholine, phosphatidylserine, and diacylglycerol.	Phosphatidylserines	257-275	protein kinase C, gamma	Rattus norvegicus	171-174
8042784-7	1994	Neither anesthetic significantly stimulated PKC activity in the presence of phosphatidylserine/diacylglycerol/Triton X-100 mixed micelles using histone H1, protamine or poly(lysine, serine) as substrate.	Phosphatidylserines	76-94	protein kinase C, gamma	Rattus norvegicus	44-47
8021276-11	1994	When the effect of annexin VI on the interaction between F-actin and calspectin was examined by low shear viscometry, annexin VI inhibited the F-actin cross-linking activity of calspectin in a Ca2+/PS-dependent manner.	Phosphatidylserines	198-200	annexin A6	Rattus norvegicus	118-128
8021276-12	1994	Cosedimentation assay showed that annexin VI dissociates calspectin from F-actin in the presence of Ca2+ and PS.	Phosphatidylserines	109-111	annexin A6	Rattus norvegicus	34-44
8026481-3	1994	Asymmetrical distributions and translocation kinetics were very different for spin-labeled phosphatidylserine and spin-labeled phosphatidylcholine in fresh platelet plasma membranes.	Phosphatidylserines	91-109	spindlin 1	Homo sapiens	78-82
8003498-3	1994	Upon Ca2+ crenation of cells, surface exposure of phosphatidylserine and phosphatidylethanolamine was observed simultaneously with inward diffusion of phosphatidylcholine.	Phosphatidylserines	50-68	carbonic anhydrase 2	Homo sapiens	5-8
8003498-4	1994	Removal of Ca2+ allowed resequestration of exposed phosphatidylserine to the membrane inner monolayer, but randomized phosphatidylethanolamine and phosphatidylcholine were not redistributed to their original states.	Phosphatidylserines	51-69	carbonic anhydrase 2	Homo sapiens	11-14
8204634-5	1994	The apparent enthalpy of association (delta H(assoc)) of both factor X and prothrombin with phosphatidylserine (PS)/phosphatidylcholine (PC) large unilamellar vesicles (LUVs, 120 nm diameter) was shown to be near 0 kcal/mol.	Phosphatidylserines	92-110	coagulation factor II, thrombin	Homo sapiens	75-86
8204634-5	1994	The apparent enthalpy of association (delta H(assoc)) of both factor X and prothrombin with phosphatidylserine (PS)/phosphatidylcholine (PC) large unilamellar vesicles (LUVs, 120 nm diameter) was shown to be near 0 kcal/mol.	Phosphatidylserines	112-114	coagulation factor II, thrombin	Homo sapiens	75-86
8200132-12	1994	Among tissues, liver showed the highest incorporation of 5,11,14-ETA into phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylinositol (PI), yet spleen PE had a higher quantity of ETA than other tissues.	Phosphatidylserines	100-118	endothelin receptor type A	Mus musculus	65-68
8200132-12	1994	Among tissues, liver showed the highest incorporation of 5,11,14-ETA into phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylinositol (PI), yet spleen PE had a higher quantity of ETA than other tissues.	Phosphatidylserines	120-122	endothelin receptor type A	Mus musculus	65-68
8180383-10	1994	IgG in prothrombin column eluates had strikingly enhanced specific lupus anticoagulant activity and also specific PS binding activity in the presence of prothrombin and calcium ions.	Phosphatidylserines	114-116	coagulation factor II, thrombin	Homo sapiens	7-18
8180383-10	1994	IgG in prothrombin column eluates had strikingly enhanced specific lupus anticoagulant activity and also specific PS binding activity in the presence of prothrombin and calcium ions.	Phosphatidylserines	114-116	coagulation factor II, thrombin	Homo sapiens	153-164
8188656-2	1994	The dependence of PKC association with phosphatidylserine-containing membranes on the concentration of Ca2+ is linear in the submicro- to submillimolar range.	Phosphatidylserines	39-57	proline rich transmembrane protein 2	Homo sapiens	18-21
7921783-4	1994	Phosphatidylglycerol, phosphatidylserine, phosphatidylinositol and phosphatidylethanolamine served as specific activators of plasma membrane-bound phospholipase C when PIP, PIP2 and PC were used as substrates.	Phosphatidylserines	22-40	prolactin induced protein	Rattus norvegicus	168-171
8091387-1	1994	This paper provides evidence to demonstrate that human prothrombin undergoes conformational changes upon binding to procoagulant membranes specifically containing phosphatidylserine (PS).	Phosphatidylserines	163-181	coagulation factor II, thrombin	Homo sapiens	55-66
8091387-4	1994	These were analyzed and interpreted in terms of changes in prothrombin domain organization associated with binding to PS-containing membranes.	Phosphatidylserines	118-120	coagulation factor II, thrombin	Homo sapiens	59-70
8179621-4	1994	A chimera containing repeat 1 of annexin V used to repeats 2, 3, and 4 of annexin I exhibited a Ca2+ requirement for PS binding close to that of annexin I, while chimeras containing repeat 1 of annexin I fused to repeats 2, 3, and 4 of annexin V required higher [Ca2+], similar to that of annexin V.	Phosphatidylserines	117-119	annexin A5	Homo sapiens	33-42
7512568-4	1994	Peptide 2303-2332, consisting of a previously identified phosphatidyl-serine binding site, prevented fVIII binding to vWf, suggesting that the sites for fVIII binding to vWf or phosphatidylserine have some overlap.	Phosphatidylserines	57-76	coagulation factor VIII	Homo sapiens	101-106
7512568-4	1994	Peptide 2303-2332, consisting of a previously identified phosphatidyl-serine binding site, prevented fVIII binding to vWf, suggesting that the sites for fVIII binding to vWf or phosphatidylserine have some overlap.	Phosphatidylserines	57-76	von Willebrand factor	Homo sapiens	118-121
7512568-4	1994	Peptide 2303-2332, consisting of a previously identified phosphatidyl-serine binding site, prevented fVIII binding to vWf, suggesting that the sites for fVIII binding to vWf or phosphatidylserine have some overlap.	Phosphatidylserines	57-76	coagulation factor VIII	Homo sapiens	153-158
7512568-4	1994	Peptide 2303-2332, consisting of a previously identified phosphatidyl-serine binding site, prevented fVIII binding to vWf, suggesting that the sites for fVIII binding to vWf or phosphatidylserine have some overlap.	Phosphatidylserines	57-76	von Willebrand factor	Homo sapiens	170-173
8159707-5	1994	Exchange of nucleotide on ARFs 1 and 3, based on increased ARF activity in a toxin assay and stimulation of binding of guanosine 5"-[gamma-[35S]thio]triphosphate, was dependent on phospholipids, with phosphatidylserine being more effective than cardiolipin.	Phosphatidylserines	200-218	ADP ribosylation factor 1	Bos taurus	26-38
8132522-6	1994	The difference increased to 740-fold using TF relipidated in vesicles composed of 80% phosphatidylcholine and 20% phosphatidylserine (TF/PCPS).	Phosphatidylserines	114-132	coagulation factor III, tissue factor	Homo sapiens	43-45
8132522-6	1994	The difference increased to 740-fold using TF relipidated in vesicles composed of 80% phosphatidylcholine and 20% phosphatidylserine (TF/PCPS).	Phosphatidylserines	114-132	coagulation factor III, tissue factor	Homo sapiens	134-136
8130278-3	1994	In the presence of calcium, phosphatidylserine and diacylglycerol, both palmitoyl-CoA (Pal-CoA) and oleoyl-CoA (Ole-CoA) enhanced particulate PK-C activity by approx.	Phosphatidylserines	28-46	proline rich transmembrane protein 2	Homo sapiens	142-146
7917792-1	1994	Phosphatidylinositol 4,5-bisphosphate (PIP2) activates protein kinase C (PKC) in the presence of phosphatidylserine and calcium.	Phosphatidylserines	97-115	proline rich transmembrane protein 2	Homo sapiens	55-71
7917792-1	1994	Phosphatidylinositol 4,5-bisphosphate (PIP2) activates protein kinase C (PKC) in the presence of phosphatidylserine and calcium.	Phosphatidylserines	97-115	proline rich transmembrane protein 2	Homo sapiens	73-76
8106403-6	1994	This substantial loss of activity was reconciled with the apparent retention of the integrity of the Ca(2+)-dependent conformation of this mutant by the finding that this Ca(2+)-dependent conformation of [Leu5--&gt;Gln]r-PC interacted poorly with mixed (60:40, w/w) phosphatidylcholine/phosphatidylserine (PL) vesicles.	Phosphatidylserines	286-304	tripartite motif containing 13	Homo sapiens	205-209
8280756-6	1994	The phospholipids PS and PI were tested for their potential to interact within three domains [L, H-1, and H-2] which compose the neurotoxin.	Phosphatidylserines	18-20	relaxin 2	Homo sapiens	106-109
8262201-4	1993	Our results indicate that the primary step in the Sap C mode of action resides in its association with PS membranes; in turn, this association promotes the interaction between the membranes and glucosylceramidase.	Phosphatidylserines	103-105	glucosylceramidase beta	Homo sapiens	194-212
8251517-1	1993	Purified adrenocortical microsomal P-450C21 was incorporated into vesicle membranes composed of phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine at a molar ratio of 5:3:1.	Phosphatidylserines	147-165	steroid 21-hydroxylase	Bos taurus	35-43
8218634-4	1993	This event was prevented by phosphatidylserine (PS), presumably through caltrin-phospholipid complex formation, whereas phosphatidylcholine (PC) was ineffective.	Phosphatidylserines	28-46	caltrin	Bos taurus	72-79
8218634-4	1993	This event was prevented by phosphatidylserine (PS), presumably through caltrin-phospholipid complex formation, whereas phosphatidylcholine (PC) was ineffective.	Phosphatidylserines	48-50	caltrin	Bos taurus	72-79
8218634-7	1993	The effect of mixtures of LPS and PS on the lysogenic property of enhancer caltrin was investigated, and it was found that PS suppressed the potentiating effect of LPS.	Phosphatidylserines	27-29	caltrin	Bos taurus	75-82
8218634-7	1993	The effect of mixtures of LPS and PS on the lysogenic property of enhancer caltrin was investigated, and it was found that PS suppressed the potentiating effect of LPS.	Phosphatidylserines	34-36	caltrin	Bos taurus	75-82
8403506-2	1993	Using a new ELISA, in which well coated phospholipids were treated with a constant amount of purified beta 2-GPI, we tried to detect the presence of APA which binds to phospholipid/beta 2-GPI complex or to phospholipids such as cardiolipin (CA) and phosphatidylserine (PS) in preeclampsia, and to check for clinical abnormalities in antibody-positive cases.	Phosphatidylserines	249-267	apolipoprotein H	Homo sapiens	102-112
8403506-2	1993	Using a new ELISA, in which well coated phospholipids were treated with a constant amount of purified beta 2-GPI, we tried to detect the presence of APA which binds to phospholipid/beta 2-GPI complex or to phospholipids such as cardiolipin (CA) and phosphatidylserine (PS) in preeclampsia, and to check for clinical abnormalities in antibody-positive cases.	Phosphatidylserines	269-271	apolipoprotein H	Homo sapiens	102-112
8276751-2	1993	MARCKS specifically binds to phosphatidylserine but not phosphatidylcholine.	Phosphatidylserines	29-47	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	0-6
8227406-6	1993	With phosphatidylserine:phosphatidylcholine vesicles at a concentration of 1 microM:2 microM, beta 2 GPI began to inhibit the reaction at a concentration of 15 nM, and at 4 microM (the normal plasma concentration) the activation of protein C was reduced to 40%.	Phosphatidylserines	5-23	apolipoprotein H	Homo sapiens	94-104
8117939-1	1993	The treatment with phosphatidylserine (PS) has recently been shown to inhibit in vivo the lipopolysaccharide (LPS)-induced release of tumor necrosis factor (TNF) (Monastra and Bruni, 1992, Lymphokine Cytokine Res.	Phosphatidylserines	19-37	tumor necrosis factor	Mus musculus	134-155
8117939-1	1993	The treatment with phosphatidylserine (PS) has recently been shown to inhibit in vivo the lipopolysaccharide (LPS)-induced release of tumor necrosis factor (TNF) (Monastra and Bruni, 1992, Lymphokine Cytokine Res.	Phosphatidylserines	19-37	tumor necrosis factor	Mus musculus	157-160
8117939-5	1993	The opposite was observed, in vitro PS enhanced TNF release.	Phosphatidylserines	36-38	tumor necrosis factor	Mus musculus	48-51
8117939-6	1993	Previous work has shown that PS induces histamine release by mast cells and it is known that histamine inhibits TNF release.	Phosphatidylserines	29-31	tumor necrosis factor	Mus musculus	112-115
8117939-9	1993	PS treatment in adrenalectomized mice was associated with an increase in TNF serum levels when compared to untreated animals.	Phosphatidylserines	0-2	tumor necrosis factor	Mus musculus	73-76
8375396-6	1993	In contrast to PKC alpha, PKC zeta exhibits a constitutive kinase activity which is independent of Ca2+, phosphatidylserine and diacylglycerol.	Phosphatidylserines	105-123	protein kinase C zeta	Homo sapiens	26-34
8375396-7	1993	Arachidonic acid alone or a combination of gamma-linolenic acid and phosphatidylserine slightly enhance PKC zeta activity.	Phosphatidylserines	68-86	protein kinase C zeta	Homo sapiens	104-112
8375396-8	1993	In the presence of the classical PKC activators phosphatidylserine/diacylglycerol, PKC alpha phosphorylates a PKC-alpha pseudosubstrate-derived peptide, an epidermal-growth-factor-receptor-derived peptide, histone III-S and myelin basic protein to an equal extent, whilst PKC zeta phosphorylates only the PKC-alpha-derived peptide.	Phosphatidylserines	48-66	protein kinase C alpha	Homo sapiens	33-36
8375396-8	1993	In the presence of the classical PKC activators phosphatidylserine/diacylglycerol, PKC alpha phosphorylates a PKC-alpha pseudosubstrate-derived peptide, an epidermal-growth-factor-receptor-derived peptide, histone III-S and myelin basic protein to an equal extent, whilst PKC zeta phosphorylates only the PKC-alpha-derived peptide.	Phosphatidylserines	48-66	protein kinase C alpha	Homo sapiens	83-92
8375396-8	1993	In the presence of the classical PKC activators phosphatidylserine/diacylglycerol, PKC alpha phosphorylates a PKC-alpha pseudosubstrate-derived peptide, an epidermal-growth-factor-receptor-derived peptide, histone III-S and myelin basic protein to an equal extent, whilst PKC zeta phosphorylates only the PKC-alpha-derived peptide.	Phosphatidylserines	48-66	protein kinase C alpha	Homo sapiens	110-119
8375396-8	1993	In the presence of the classical PKC activators phosphatidylserine/diacylglycerol, PKC alpha phosphorylates a PKC-alpha pseudosubstrate-derived peptide, an epidermal-growth-factor-receptor-derived peptide, histone III-S and myelin basic protein to an equal extent, whilst PKC zeta phosphorylates only the PKC-alpha-derived peptide.	Phosphatidylserines	48-66	myelin basic protein	Homo sapiens	224-244
8375396-8	1993	In the presence of the classical PKC activators phosphatidylserine/diacylglycerol, PKC alpha phosphorylates a PKC-alpha pseudosubstrate-derived peptide, an epidermal-growth-factor-receptor-derived peptide, histone III-S and myelin basic protein to an equal extent, whilst PKC zeta phosphorylates only the PKC-alpha-derived peptide.	Phosphatidylserines	48-66	protein kinase C zeta	Homo sapiens	272-280
8375396-8	1993	In the presence of the classical PKC activators phosphatidylserine/diacylglycerol, PKC alpha phosphorylates a PKC-alpha pseudosubstrate-derived peptide, an epidermal-growth-factor-receptor-derived peptide, histone III-S and myelin basic protein to an equal extent, whilst PKC zeta phosphorylates only the PKC-alpha-derived peptide.	Phosphatidylserines	48-66	protein kinase C alpha	Homo sapiens	305-314
8247222-8	1993	However, after 17 days, PS restored the K(+)-induced B-50/GAP-43 phosphorylation.	Phosphatidylserines	24-26	growth associated protein 43	Rattus norvegicus	58-64
8247222-9	1993	It is proposed that repeated PS administrations might be beneficial to the age-induced deterioration of endogenous B-50/GAP-43 phosphorylation by acting on Ca++ homeostatic mechanisms and/or PKC.	Phosphatidylserines	29-31	growth associated protein 43	Rattus norvegicus	120-126
8349610-3	1993	In an analysis of the enzymatic and membrane binding properties of dynamin, we have found that the acidic phospholipids, phosphatidylserine, phosphatidylglycerol, and phosphatidylinositol, are able to stimulate GTP hydrolysis in a manner similar to activation previously shown with microtubules.	Phosphatidylserines	121-139	shibire	Drosophila melanogaster	67-74
8318006-2	1993	Annexin 5 promoted a dose-dependent inhibition of annexin 1 phosphorylation, which could be overcome by increasing the concentration of phosphatidylserine (PtdSer).	Phosphatidylserines	136-154	annexin A5	Homo sapiens	0-9
8318006-2	1993	Annexin 5 promoted a dose-dependent inhibition of annexin 1 phosphorylation, which could be overcome by increasing the concentration of phosphatidylserine (PtdSer).	Phosphatidylserines	136-154	annexin A1	Homo sapiens	50-59
8400120-8	1993	A major role for phosphatidylserine in the regulation of T cell activation emerged, since we demonstrated that a panel of K+ channel blockers enhanced the synthesis of this phospholipid mimicking the previously described effect of exogenously added phosphatidylserine in Jurkat cells, i.e., a blockade of interleukin-2 synthesis probably due to a defect in diacylglycerol production.	Phosphatidylserines	17-35	interleukin 2	Homo sapiens	305-318
8400120-8	1993	A major role for phosphatidylserine in the regulation of T cell activation emerged, since we demonstrated that a panel of K+ channel blockers enhanced the synthesis of this phospholipid mimicking the previously described effect of exogenously added phosphatidylserine in Jurkat cells, i.e., a blockade of interleukin-2 synthesis probably due to a defect in diacylglycerol production.	Phosphatidylserines	249-267	interleukin 2	Homo sapiens	305-318
8496137-7	1993	We now show that the rac-GAP activity of n-chimaerin is stimulated by phosphatidylserine (PS) and phosphatidic acid (PA) and that phorbol esters can synergize with PS and PA.	Phosphatidylserines	70-88	chimerin 1	Mus musculus	41-52
8496137-7	1993	We now show that the rac-GAP activity of n-chimaerin is stimulated by phosphatidylserine (PS) and phosphatidic acid (PA) and that phorbol esters can synergize with PS and PA.	Phosphatidylserines	90-92	chimerin 1	Mus musculus	41-52
8496137-7	1993	We now show that the rac-GAP activity of n-chimaerin is stimulated by phosphatidylserine (PS) and phosphatidic acid (PA) and that phorbol esters can synergize with PS and PA.	Phosphatidylserines	164-166	chimerin 1	Mus musculus	41-52
8486722-7	1993	Phosphatidylserine but not phosphatidylcholine inhibited phosphorylation of MARCKS by protein kinase C. MARCKS seems to bind to the biomembranes through two binding sites: the N-terminal myristoyl moiety and the basic phosphorylation domain of amphiphilic nature.	Phosphatidylserines	0-18	myristoylated alanine rich protein kinase C substrate	Homo sapiens	76-82
8486722-7	1993	Phosphatidylserine but not phosphatidylcholine inhibited phosphorylation of MARCKS by protein kinase C. MARCKS seems to bind to the biomembranes through two binding sites: the N-terminal myristoyl moiety and the basic phosphorylation domain of amphiphilic nature.	Phosphatidylserines	0-18	myristoylated alanine rich protein kinase C substrate	Homo sapiens	104-110
8364491-4	1993	Tryptic digestion of insulin was accelerated by negatively-charged liposomes (containing 10% phosphatidylserine, phosphatidylinositol, or phosphatidic acid) or by neutral empty liposomes, this digestion being enhanced by progressively smaller liposome size (from 2 to 0.1 microns) in the case of neutral empty liposomes.	Phosphatidylserines	93-111	insulin	Homo sapiens	21-28
8387776-2	1993	PLC delta bound weakly to vesicles composed of phosphatidylserine (PS) or phosphatidylcholine (PC) or phosphatidylethanolamine (PE) + PC, and even more weakly to vesicles composed of phosphatidylinositol.	Phosphatidylserines	47-65	phospholipase C delta 1	Homo sapiens	0-9
8387776-2	1993	PLC delta bound weakly to vesicles composed of phosphatidylserine (PS) or phosphatidylcholine (PC) or phosphatidylethanolamine (PE) + PC, and even more weakly to vesicles composed of phosphatidylinositol.	Phosphatidylserines	67-69	phospholipase C delta 1	Homo sapiens	0-9
8387776-7	1993	These showed that 50% binding of PLC delta occurred at a level of 0.9 nmol/ml PIP2 with 80 nmol/ml PC; at 2.2 nmol/ml PIP2 with 170 nmol/ml PS; at 4.2 nmol/ml PIP2 with 320 nmol/ml PI; and at 0.26 nmol/ml PIP2 with 20 nmol/ml total liver phospholipids.	Phosphatidylserines	140-142	phospholipase C delta 1	Homo sapiens	33-42
8484721-5	1993	The site for strong binding of PS seems to be located in the N-terminal part of the 34 kDa C-terminal fragment of caldesmon.	Phosphatidylserines	31-33	caldesmon 1	Homo sapiens	114-123
8484721-6	1993	Binding of PS at this site results in displacement of calmodulin from its complex with caldesmon.	Phosphatidylserines	11-13	calmodulin 1	Homo sapiens	54-64
8484721-6	1993	Binding of PS at this site results in displacement of calmodulin from its complex with caldesmon.	Phosphatidylserines	11-13	caldesmon 1	Homo sapiens	87-96
8386623-6	1993	Mixtures of phosphatidylcholine/phosphatidylserine or phospholipids/phosphatidylserine, in ratios of 1-4, increased the insulin-induced tyrosine kinase activation in a dose-dependent manner.	Phosphatidylserines	32-50	insulin	Homo sapiens	120-127