PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 19647296-1 2009 OBJECTIVES: To examine the association between 2 mitochondrial manganese superoxide dismutase (MnSOD) genetic polymorphisms (Ala-9Val and Ala-16Val) and prostate cancer susceptibility. ala-9val 125-133 superoxide dismutase 2 Homo sapiens 63-93 19715479-9 2009 The NQO1 C609T polymorphism may influence steroid resistance of UC patients, while the SOD2 Ala-9Val polymorphism may influence age of onset of UC. ala-9val 92-100 superoxide dismutase 2 Homo sapiens 87-91 19712751-2 2009 We investigated the relationship between the MnSOD Ala-9Val polymorphism and breast cancer. ala-9val 51-59 superoxide dismutase 2 Homo sapiens 45-50 19712751-6 2009 In conclusion, the MnSOD Ala-9Val polymorphism may contribute to an increased risk for breast cancer development, particularly in the presence of a higher level of education, high BMI, late age at first pregnancy, and premenopausal status. ala-9val 25-33 superoxide dismutase 2 Homo sapiens 19-24 19929244-2 2010 The aim of this study was to assess the role of common variation in three polymorphic genes (MnSOD Ala-9Val, GPX1 Pro198Leu and CAT -262 C > T) coding for antioxidant defence enzymes in modulating individual susceptibility to hepatocellular carcinoma (HCC) using a case-control study (cases = 96 and controls = 222). ala-9val 99-107 superoxide dismutase 2 Homo sapiens 93-98 20041472-9 2010 Furthermore, we find evidence for an association between Ala-9Val (MnSOD) and TDof, but not TDlt. ala-9val 57-65 superoxide dismutase 2 Homo sapiens 67-72 19647296-1 2009 OBJECTIVES: To examine the association between 2 mitochondrial manganese superoxide dismutase (MnSOD) genetic polymorphisms (Ala-9Val and Ala-16Val) and prostate cancer susceptibility. ala-9val 125-133 superoxide dismutase 2 Homo sapiens 95-100 18977034-2 2008 The combined genotypes of T/T in NQO1 Pro187Ser and Val/Val in MnSOD Ala-9Val polymorphisms were found to be independently associated with a significantly higher risk of TD. ala-9val 69-77 NAD(P)H quinone dehydrogenase 1 Homo sapiens 33-37 18790709-0 2008 Manganese superoxide dismutase gene Ala-9Val polymorphism might be related to the severity of abnormal involuntary movements in Korean schizophrenic patients. ala-9val 36-44 superoxide dismutase 2 Homo sapiens 0-30 18790709-1 2008 OBJECTIVE: This study examined whether the manganese superoxide dismutase (MnSOD) gene Ala-9Val single-nucleotide polymorphism (SNP) is associated with neuroleptic-induced tardive dyskinesia (TD) and the severity of the abnormal involuntary movements in Korean schizophrenic patients. ala-9val 87-95 superoxide dismutase 2 Homo sapiens 43-73 18977034-2 2008 The combined genotypes of T/T in NQO1 Pro187Ser and Val/Val in MnSOD Ala-9Val polymorphisms were found to be independently associated with a significantly higher risk of TD. ala-9val 69-77 superoxide dismutase 2 Homo sapiens 63-68 18790709-1 2008 OBJECTIVE: This study examined whether the manganese superoxide dismutase (MnSOD) gene Ala-9Val single-nucleotide polymorphism (SNP) is associated with neuroleptic-induced tardive dyskinesia (TD) and the severity of the abnormal involuntary movements in Korean schizophrenic patients. ala-9val 87-95 superoxide dismutase 2 Homo sapiens 75-80 18023606-10 2008 Our findings provide further evidence of an association between the Ala-9Val MnSOD polymorphism and HCC occurrence in hepatitis C virus-infected Moroccan patients. ala-9val 68-76 superoxide dismutase 2 Homo sapiens 77-82 17336594-3 2007 The aim of this study was to assess the influence of the Ala-9Val MnSOD dimorphism on the same parameters and events in hepatitis C virus (HCV)-infected patients. ala-9val 57-65 superoxide dismutase 2 Homo sapiens 66-71 16626843-3 2006 The patients with MDD and BD, and the controls had a similar distribution of the genotypes and alleles in the Ala-9Val MnSOD polymorphism. ala-9val 110-118 superoxide dismutase 2 Homo sapiens 119-124 17291655-0 2007 Association between the MnSOD Ala-9Val polymorphism and development of schizophrenia and abnormal involuntary movements in the Xhosa population. ala-9val 30-38 superoxide dismutase 2 Homo sapiens 24-29 17291655-2 2007 Recently, the functional polymorphism (Ala-9Val) in the manganese superoxide dismutase (MnSOD) gene (part of the antioxidant defense mechanism) was found to be associated with schizophrenia in a Turkish population. ala-9val 39-47 superoxide dismutase 2 Homo sapiens 56-86 17291655-2 2007 Recently, the functional polymorphism (Ala-9Val) in the manganese superoxide dismutase (MnSOD) gene (part of the antioxidant defense mechanism) was found to be associated with schizophrenia in a Turkish population. ala-9val 39-47 superoxide dismutase 2 Homo sapiens 88-93 17465268-3 2007 The aim of this study was to investigate the relationship between prostate cancer and MnSOD Ala-9Val polymorphism in Turkish men with prostate cancer. ala-9val 92-100 superoxide dismutase 2 Homo sapiens 86-91 17822322-1 2007 The aim of the study was to investigate relationship between activity of superoxide dismutase (SOD), malondialdehyde (MDA) and tumor necrosis factor alpha (TNFalpha) and between Ala-9Val polymorphism in the gene encoding MnSOD (SOD2) and the initial stage and prognosis of the head and neck squamous cell carcinoma (HNSCC). ala-9val 178-186 superoxide dismutase 1 Homo sapiens 73-93 17822322-1 2007 The aim of the study was to investigate relationship between activity of superoxide dismutase (SOD), malondialdehyde (MDA) and tumor necrosis factor alpha (TNFalpha) and between Ala-9Val polymorphism in the gene encoding MnSOD (SOD2) and the initial stage and prognosis of the head and neck squamous cell carcinoma (HNSCC). ala-9val 178-186 superoxide dismutase 2 Homo sapiens 221-226 17822322-1 2007 The aim of the study was to investigate relationship between activity of superoxide dismutase (SOD), malondialdehyde (MDA) and tumor necrosis factor alpha (TNFalpha) and between Ala-9Val polymorphism in the gene encoding MnSOD (SOD2) and the initial stage and prognosis of the head and neck squamous cell carcinoma (HNSCC). ala-9val 178-186 superoxide dismutase 2 Homo sapiens 228-232 17822322-6 2007 Genotype and allele frequencies of the Ala-9Val differed neither between groups defined according to the stage of primary disease (TNM), nor between relapse vs. remission groups after the follow-up (p>0.05). ala-9val 39-47 teneurin transmembrane protein 1 Homo sapiens 131-134 16933053-0 2006 Manganese superoxide dismutase Ala-9Val polymorphism, environmental modifiers, and risk of breast cancer in a German population. ala-9val 31-39 superoxide dismutase 2 Homo sapiens 0-30 16933053-8 2006 CONCLUSIONS: The MnSOD Ala-9Val polymorphism may contribute to an increase in breast cancer risk in the context of high alcohol consumption, however the polymorphism is not an overall risk factor for breast cancer in this primarily premenopausal population. ala-9val 23-31 superoxide dismutase 2 Homo sapiens 17-22 16780268-3 2006 THE AIM OF THE WORK: An attempt of evaluation of Ala-9Val polymorphism in gene for MnSOD in schizophrenic patients and control group was undertaken. ala-9val 49-57 superoxide dismutase 2 Homo sapiens 83-88 16571366-0 2006 Comments on "Association between Ala-9Val polymorphism of MnSOD gene and schizophrenia" by O. Akyol et al. ala-9val 33-41 superoxide dismutase 2 Homo sapiens 58-63 16423340-1 2006 OBJECTIVES: To investigate the possible association between functional variant Ala-9Val in the MnSOD gene and asthma in the case-control study comprising 626 Caucasian subjects. ala-9val 79-87 superoxide dismutase 2 Homo sapiens 95-100 16780268-14 2006 The lack of association between selected social - demographic and clinical factors of schizophrenic patients and Ala-9Val polymorphism in a gene for MnSOD. ala-9val 113-121 superoxide dismutase 2 Homo sapiens 149-154 16485861-8 2005 CONCLUSIONS: Our data suggest that the Ala-9Val polymorphism in the MnSOD gene is not associated with genetic susceptibility in AD patients. ala-9val 39-47 superoxide dismutase 2 Homo sapiens 68-73 15386537-2 2005 An alanine-9valine (Ala-9Val) polymorphism in the mitochondrial targeting sequence of MnSOD has been described and has recently been associated with risk of human breast cancer. ala-9val 20-28 superoxide dismutase 2 Homo sapiens 86-91 15883815-4 2005 A polymorphism (Ala-9Val) in the mitochondrial targeting sequence (MTS) of the MnSOD gene has been proposed to affect protein localization and thereby influence cellular defence against superoxide radicals. ala-9val 16-24 superoxide dismutase 2 Homo sapiens 79-84 15386537-4 2005 Ala-9Val polymorphism in the signal sequence of the protein for MnSOD was determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay in a study population. ala-9val 0-8 superoxide dismutase 2 Homo sapiens 64-69 27100222-3 2016 In this study, we aimed to investigate possible associations of MnSOD Ala-9Val and GPx1 Pro198Leu polymorphisms with vitiligo with in Turkish population. ala-9val 70-78 superoxide dismutase 2 Homo sapiens 64-69 15589819-0 2004 The Ala-9Val polymorphism in the mitochondrial targeting sequence (MTS) of the manganese superoxide dismutase gene is not associated with juvenile-onset asthma. ala-9val 4-12 superoxide dismutase 2 Homo sapiens 79-109 15193990-2 2004 Two allelic variants have been described for the SOD2 gene (Ile58Thr involves a C to T substitution at nucleotide residue 339 and Ala-9Val involves a T to C substitution at nucleotide residue 1183). ala-9val 130-138 superoxide dismutase 2 Homo sapiens 49-53 15217492-1 2004 INTRODUCTION: A polymorphism in the manganese superoxide dismutase (MnSOD) gene, Ala-9Val, has been examined in association with breast cancer risk in several epidemiologic studies. ala-9val 81-89 superoxide dismutase 2 Homo sapiens 68-73 15217492-3 2004 METHODS: We examined the role of the MnSOD Ala-9Val polymorphism in a population-based case-control study of invasive and in situ breast cancer in North Carolina. ala-9val 43-51 superoxide dismutase 2 Homo sapiens 37-42 10529750-1 1999 An alanin-9valin (Ala-9Val) polymorphism in the mitochondrial targeting sequence of manganese-containing superoxide dismutase (Mn-SOD) has recently been described. ala-9val 18-26 superoxide dismutase 2 Homo sapiens 84-125 10529750-1 1999 An alanin-9valin (Ala-9Val) polymorphism in the mitochondrial targeting sequence of manganese-containing superoxide dismutase (Mn-SOD) has recently been described. ala-9val 18-26 superoxide dismutase 2 Homo sapiens 127-133 8806673-5 1996 We here identify diallelic polymorphism (Ala-9Val) in the MTS of human MnSOD in a Japanese population. ala-9val 41-49 superoxide dismutase 2 Homo sapiens 71-76 15610954-0 2005 Association between Ala-9Val polymorphism of Mn-SOD gene and schizophrenia. ala-9val 20-28 superoxide dismutase 2 Homo sapiens 45-51 15610954-4 2005 The present study was performed to assess whether there is a genetic association between a functional polymorphism (Ala-9Val) in the human Mn-SOD gene in schizophrenic patients (n=153) and healthy controls (n=196) using a PCR/RFLP method. ala-9val 116-124 superoxide dismutase 2 Homo sapiens 139-145 15217492-0 2004 Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case-control study of African Americans and whites. ala-9val 31-39 superoxide dismutase 2 Homo sapiens 0-30 15217492-1 2004 INTRODUCTION: A polymorphism in the manganese superoxide dismutase (MnSOD) gene, Ala-9Val, has been examined in association with breast cancer risk in several epidemiologic studies. ala-9val 81-89 superoxide dismutase 2 Homo sapiens 36-66 10882843-2 2000 In the present study, we investigated the genetic association between a functional polymorphism (Ala-9Val) in the human manganese (Mn) SOD gene and schizophrenia or TD (192 schizophrenics: 39 with TD and 153 without TD; 141 controls). ala-9val 97-105 superoxide dismutase 2 Homo sapiens 135-138 27100222-5 2016 Genotyping is performed to identify MnSOD Ala-9Val and GPx1 Pro198Leu polymorphisms. ala-9val 42-50 superoxide dismutase 2 Homo sapiens 36-41 27100222-8 2016 Although no significant difference was found, this is the first report investigating the possible associations between the MnSOD Ala-9Val and GPx1 Pro198Leu polymorphisms in Turkish population. ala-9val 129-137 superoxide dismutase 2 Homo sapiens 123-128 27100222-8 2016 Although no significant difference was found, this is the first report investigating the possible associations between the MnSOD Ala-9Val and GPx1 Pro198Leu polymorphisms in Turkish population. ala-9val 129-137 glutathione peroxidase 1 Homo sapiens 142-146 26885102-3 2015 Therefore, we aimed to examine the possible associations between the MnSOD Ala-9Val and GPx1 Pro 198 Leu polymorphisms and AA susceptibility and disease progression in Turkish population. ala-9val 75-83 superoxide dismutase 2 Homo sapiens 69-74 26544677-0 2016 Association of the manganese superoxide dismutase gene Ala-9Val polymorphism with age of smoking initiation in male schizophrenia smokers. ala-9val 55-63 superoxide dismutase 2 Homo sapiens 19-49 26544677-5 2016 In this study, we hypothesized that the functional polymorphism of MnSOD Ala-9Val was associated with smoking in patients with schizophrenia. ala-9val 73-81 superoxide dismutase 2 Homo sapiens 67-72 26544677-10 2016 These results suggest that the MnSOD Ala-9Val polymorphism may not influence smoking status in a Chinese male schizophrenia population, but may influence the age at which smoking is started among schizophrenia smokers. ala-9val 37-45 superoxide dismutase 2 Homo sapiens 31-36 26885102-9 2015 CONCLUSIONS: This study is unique since an investigation to reveal the possible associations between the MnSOD Ala-9Val and GPx1 Pro 198 Leu polymorphisms and AA susceptibility and in Turkish population. ala-9val 111-119 superoxide dismutase 2 Homo sapiens 105-110 26885102-5 2015 Genotyping was performed to identify MnSOD Ala-9Val and GPx1 Pro 198 Leu polymorphisms by a method based on PCR amplification and detection of polymorphisms with hybridization probes labeled with fluorescent dyes. ala-9val 43-51 superoxide dismutase 2 Homo sapiens 37-42 26528342-4 2015 Determination of MnSOD Ala-9Val and GPX1 Pro198Leu polymorphisms was performed using real-time polymerase chain reaction amplification. ala-9val 23-31 superoxide dismutase 2 Homo sapiens 17-22 26885102-9 2015 CONCLUSIONS: This study is unique since an investigation to reveal the possible associations between the MnSOD Ala-9Val and GPx1 Pro 198 Leu polymorphisms and AA susceptibility and in Turkish population. ala-9val 111-119 glutathione peroxidase 1 Homo sapiens 124-128 26356721-3 2015 Ala-9Val polymorphism, a functional polymorphism of MnSOD gene, has been reported to be related to the risk of schizophrenia and TD. ala-9val 0-8 superoxide dismutase 2 Homo sapiens 52-57 26356721-5 2015 We performed meta-analyses aiming to assess the association between MnSOD activity and schizophrenia, as well as the association of MnSOD Ala-9Val polymorphism with schizophrenia and TD in schizophrenic patients.We search for the literature on MnSOD and schizophrenia in English or Chinese published up to May 1, 2015 on PubMed, EMBASE, the Cochrane Databases, Chinese National Knowledge Infrastructure, China Biology Medical and Wanfang databases. ala-9val 138-146 superoxide dismutase 2 Homo sapiens 132-137 26356721-5 2015 We performed meta-analyses aiming to assess the association between MnSOD activity and schizophrenia, as well as the association of MnSOD Ala-9Val polymorphism with schizophrenia and TD in schizophrenic patients.We search for the literature on MnSOD and schizophrenia in English or Chinese published up to May 1, 2015 on PubMed, EMBASE, the Cochrane Databases, Chinese National Knowledge Infrastructure, China Biology Medical and Wanfang databases. ala-9val 138-146 superoxide dismutase 2 Homo sapiens 132-137 26356721-14 2015 Longitudinal studies with larger sample sizes and different ethnicities are needed to confirm the association of the MnSOD Ala-9Val variants with schizophrenia and TD. ala-9val 123-131 superoxide dismutase 2 Homo sapiens 117-122 24212762-2 2014 In this study, we aimed to examine to investigate possible associations between the manganese superoxide dismutase (MnSOD Ala-9Val) and glutathione peroxidase (GPx1 Pro198Leu) polymorphisms and psoriasis susceptibility and disease progression in a Turkish population. ala-9val 122-130 superoxide dismutase 2 Homo sapiens 116-121 23588476-0 2014 Cognitive function, plasma MnSOD activity, and MnSOD Ala-9Val polymorphism in patients with schizophrenia and normal controls. ala-9val 53-61 superoxide dismutase 2 Homo sapiens 47-52 23588476-2 2014 The functional Ala-9Val polymorphism of the mitochondrial enzyme manganese superoxide dismutase (MnSOD), which detoxifies superoxide radicals to hydrogen peroxide, has been associated with schizophrenia. ala-9val 15-23 superoxide dismutase 2 Homo sapiens 97-102 23588476-4 2014 We recruited 923 schizophrenic inpatients and 566 healthy controls and compared them on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), plasma MnSOD activity, and the MnSOD Ala-9Val polymorphism. ala-9val 205-213 superoxide dismutase 2 Homo sapiens 199-204 23588476-6 2014 We showed that the MnSOD Ala-9Val polymorphism may not contribute directly to the susceptibility to schizophrenia. ala-9val 25-33 superoxide dismutase 2 Homo sapiens 19-24 23588476-11 2014 The association between higher MnSOD activity and cognitive impairment in schizophrenia is dependent on the MnSOD Ala-9Val polymorphism. ala-9val 114-122 superoxide dismutase 2 Homo sapiens 31-36 23588476-11 2014 The association between higher MnSOD activity and cognitive impairment in schizophrenia is dependent on the MnSOD Ala-9Val polymorphism. ala-9val 114-122 superoxide dismutase 2 Homo sapiens 108-113 24212762-2 2014 In this study, we aimed to examine to investigate possible associations between the manganese superoxide dismutase (MnSOD Ala-9Val) and glutathione peroxidase (GPx1 Pro198Leu) polymorphisms and psoriasis susceptibility and disease progression in a Turkish population. ala-9val 122-130 glutathione peroxidase 1 Homo sapiens 160-164 24212762-5 2014 Genotyping was performed to identify MnSOD Ala-9Val and GPx1 Pro198Leu polymorphisms by a method based on PCR amplification and detection of polymorphisms with hybridization probes labeled with fluorescent dyes. ala-9val 43-51 superoxide dismutase 2 Homo sapiens 37-42 24212762-10 2014 This is the first report investigating the possible associations between the MnSOD Ala-9Val and GPx1 Pro198Leu polymorphisms and psoriasis susceptibility and disease progression in the Turkish population even if no significant difference was found between patient groups and control subjects. ala-9val 83-91 superoxide dismutase 2 Homo sapiens 77-82 24212762-10 2014 This is the first report investigating the possible associations between the MnSOD Ala-9Val and GPx1 Pro198Leu polymorphisms and psoriasis susceptibility and disease progression in the Turkish population even if no significant difference was found between patient groups and control subjects. ala-9val 83-91 glutathione peroxidase 1 Homo sapiens 96-100 22704671-4 2012 Genotyping was performed to identify MnSOD Ala-9Val and GPx1 Pro198Leu polymorphisms by a method based on PCR amplification and detection of polymorphisms with hybridization probes labeled with fluorescent dyes. ala-9val 43-51 superoxide dismutase 2 Homo sapiens 37-42 23725507-3 2013 The patients with BD and MDD and the controls had a similar distribution of the genotypes and alleles in the Ala-9Val MnSOD gene polymorphism. ala-9val 109-117 superoxide dismutase 2 Homo sapiens 118-123 22983815-0 2013 Participation of 47C>T SNP (Ala-9Val polymorphism) of the SOD2 gene in the intracellular environment of human peripheral blood mononuclear cells with and without lipopolysaccharides. ala-9val 31-39 superoxide dismutase 2 Homo sapiens 61-65 22704671-6 2012 RESULTS: The genotype distribution of the MnSOD Ala-9Val single nucleotide polymorphism was significantly different for the controls and the recurrent tonsillitis patients (P=0.009). ala-9val 48-56 superoxide dismutase 2 Homo sapiens 42-47 22704671-9 2012 In addition, the frequency of tonsillitis was significantly higher in recurrent tonsillitis patients with the MnSOD Ala-9Val polymorphism than the patients with wild-type (P=0.008). ala-9val 116-124 superoxide dismutase 2 Homo sapiens 110-115 22704671-12 2012 And we suggest that there may be a possible relation between local and recurrent infections or inflammation of the tonsillar tissue and the MnSOD Ala-9Val single nucleotide polymorphism in pediatric patients with RT. ala-9val 146-154 superoxide dismutase 2 Homo sapiens 140-145 21904836-3 2012 Genotyping of the MnSOD Ala-9Val and GPX1 Pro198Leu polymorphisms was carried out by PCR-RFLP. ala-9val 24-32 superoxide dismutase 2 Homo sapiens 18-23 21574139-0 2011 Ala-9Val polymorphism of Mn-SOD gene in sickle cell anemia. ala-9val 0-8 superoxide dismutase 2 Homo sapiens 25-31 22699057-9 2012 CONCLUSION: MnSOD Ala-9Val polymorphism can be region- and race-related, and it is not correlated to the genetic susceptibility of NPC in Cantonese. ala-9val 18-26 superoxide dismutase 2 Homo sapiens 12-17 21574139-2 2011 We looked for a possible genetic association between the functional polymorphism Ala-9Val in the human Mn-SOD gene and sickle cell anemia. ala-9val 81-89 superoxide dismutase 2 Homo sapiens 103-109 20567899-0 2011 Possible risk modifications in the association between MnSOD Ala-9Val polymorphism and breast cancer risk: subgroup analysis and evidence-based sample size calculation for a future trial. ala-9val 61-69 superoxide dismutase 2 Homo sapiens 55-60 20567899-2 2011 A number of subsequent population-based studies have investigated the association between MnSOD Ala-9Val polymorphism and the risk of breast cancer. ala-9val 96-104 superoxide dismutase 2 Homo sapiens 90-95 20567899-4 2011 This fact implies that the effect of MnSOD Ala-9Val polymorphism on the susceptibility to breast cancer may be modified by other risk factors. ala-9val 43-51 superoxide dismutase 2 Homo sapiens 37-42 20346996-0 2010 Association of the manganese superoxide dismutase gene Ala-9Val polymorphism with clinical phenotypes and tardive dyskinesia in schizophrenic patients. ala-9val 55-63 superoxide dismutase 2 Homo sapiens 19-49 20346996-1 2010 OBJECTIVE: Several recent studies that have investigated the genetic association between the manganese superoxide dismutase (MnSOD) gene Ala-9Val single-nucleotide polymorphism (SNP) and tardive dyskinesia (TD) have produced conflicting results. ala-9val 137-145 superoxide dismutase 2 Homo sapiens 93-123 20346996-1 2010 OBJECTIVE: Several recent studies that have investigated the genetic association between the manganese superoxide dismutase (MnSOD) gene Ala-9Val single-nucleotide polymorphism (SNP) and tardive dyskinesia (TD) have produced conflicting results. ala-9val 137-145 superoxide dismutase 2 Homo sapiens 125-130 20346996-8 2010 CONCLUSION: While the MnSOD gene Ala-9Val polymorphism did not play a major role in the susceptibility to TD in schizophrenic patients, it might be associated with negative symptoms of schizophrenia. ala-9val 33-41 superoxide dismutase 2 Homo sapiens 22-27