PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
3761757-2	1986	The IC50 values of tiapride, sulpiride and haloperidol were estimated as follows: 1440, 132 and 0.295 microM for D-1; 45.8, 8.8 and 0.004 microM for D-2; greater than 100, greater than 100 and 0.64 microM for D-3; 11.7, 2.88 and 0.0044 microM for D-4, respectively.	Tiapride Hydrochloride	19-27	solute carrier family 3 member 1	Rattus norvegicus	149-152
3761757-3	1986	It is suggested that the affinity of tiapride is high to D-2 and D-4, but is not high to D-1 and D-3.	Tiapride Hydrochloride	37-45	solute carrier family 3 member 1	Rattus norvegicus	57-68
3761757-5	1986	In the D-2 receptor assay, the IC50 values of tiapride and sulpiride were 1/22.7 and 1/19.1 of those in the presence of 100 mM NaCl, respectively, suggesting that benzamide drug binds to the D-2 subtype with higher affinity in the presence of Na+ than in the control.	Tiapride Hydrochloride	46-54	solute carrier family 3 member 1	Rattus norvegicus	7-10
3761757-5	1986	In the D-2 receptor assay, the IC50 values of tiapride and sulpiride were 1/22.7 and 1/19.1 of those in the presence of 100 mM NaCl, respectively, suggesting that benzamide drug binds to the D-2 subtype with higher affinity in the presence of Na+ than in the control.	Tiapride Hydrochloride	46-54	solute carrier family 3 member 1	Rattus norvegicus	191-194
7256107-1	1981	The authors report results attained by means of a replaced benzamide, thiapride, in the treatment of 21 subjects showing involuntary movements of extra-pyramidal origin and more exactly: extra-pyramidal syndromes due to drugs (3), idiopathic dyscinesias (8), choreas (6), dystonias (3), essential tremor (1).	Tiapride Hydrochloride	70-79	dopamine receptor D3	Homo sapiens	287-307
3906426-2	1985	Tiapride induced an increase of prolactin plasma levels, on the average, from 1,195 to 2,179 microIU/ml (p less than 0.01).	Tiapride Hydrochloride	0-8	prolactin	Homo sapiens	32-41
6262702-0	1981	Effects of tiapride infusion on plasma levels of beta-endorphin, prolactin and dopamine in patients with pain from cancer.	Tiapride Hydrochloride	11-19	proopiomelanocortin	Homo sapiens	49-63
6262702-0	1981	Effects of tiapride infusion on plasma levels of beta-endorphin, prolactin and dopamine in patients with pain from cancer.	Tiapride Hydrochloride	11-19	prolactin	Homo sapiens	65-74
6262702-4	1981	The tiapride infusion produced a slight but significant increase in plasma beta-endorphin level, an early and significant increase in plasma prolactin, and a sudden and highly significant decrease in plasma dopamine.	Tiapride Hydrochloride	4-12	proopiomelanocortin	Homo sapiens	75-89
6262702-4	1981	The tiapride infusion produced a slight but significant increase in plasma beta-endorphin level, an early and significant increase in plasma prolactin, and a sudden and highly significant decrease in plasma dopamine.	Tiapride Hydrochloride	4-12	prolactin	Homo sapiens	141-150
26754356-6	2016	Good orthogonality (>0.9) separation was achieved and three AChE inhibitors (tiapride, amisulpride, and lamotrigine), used as antipsychotic medicines, were identified and confirmed by two-dimensional retention alignment as well as their AChE inhibition activity.	Tiapride Hydrochloride	80-88	acetylcholinesterase (Cartwright blood group)	Homo sapiens	63-67
494989-3	1979	Tiapride, a benzamide derivative with dopaminergic blocking activity at the level of the lactotrophes, increased mean PRL secretion in each subject but a permanent hyperprolactinaemia above 700 uU/ml was attained only in one subject.	Tiapride Hydrochloride	0-8	prolactin	Homo sapiens	118-121
6269192-0	1981	[Effects of tiapride infusion on plasma levels of beta-endorphin, prolactin and dopamine in patients with pain from cancer (author"s transl)].	Tiapride Hydrochloride	12-20	proopiomelanocortin	Homo sapiens	50-64
6269192-0	1981	[Effects of tiapride infusion on plasma levels of beta-endorphin, prolactin and dopamine in patients with pain from cancer (author"s transl)].	Tiapride Hydrochloride	12-20	prolactin	Homo sapiens	66-75
6269192-4	1981	The tiapride infusion produced a slight but significant increase in plasma beta-endorphin level, an early and significant increase in plasma prolactin, and a sudden and highly significant decrease in plasma dopamine.	Tiapride Hydrochloride	4-12	proopiomelanocortin	Homo sapiens	75-89
6269192-4	1981	The tiapride infusion produced a slight but significant increase in plasma beta-endorphin level, an early and significant increase in plasma prolactin, and a sudden and highly significant decrease in plasma dopamine.	Tiapride Hydrochloride	4-12	prolactin	Homo sapiens	141-150
11692072-0	2001	Influence of the dopamine D2 receptor (DRD2) exon 8 genotype on efficacy of tiapride and clinical outcome of alcohol withdrawal.	Tiapride Hydrochloride	76-84	dopamine receptor D2	Homo sapiens	17-37
21165329-0	2010	Response of i(kr) and HERG currents to the antipsychotics tiapride and sulpiride.	Tiapride Hydrochloride	58-66	potassium voltage-gated channel subfamily H member 2	Homo sapiens	22-26
21165329-2	2010	We studied the effects of two antipsychotics, tiapride and sulpiride, on hERG channels expressed in Xenopus oocytes and also on delayed rectifier K(+) currents in guinea pig cardiomyocytes.	Tiapride Hydrochloride	46-54	ETS transcription factor ERG	Homo sapiens	73-77
21165329-4	2010	However, our findings did show that tiapride increased the potential for half-maximal activation (V(1/2)) of HERG at 10~300 microM, whereas sulpiride increased the maximum conductance (G(max)) at 3, 10 and 100 microM.	Tiapride Hydrochloride	36-44	potassium voltage-gated channel subfamily H member 2	Homo sapiens	109-113
16036766-5	2005	In the present paper the authors present their results using another benzamide with weak cholinesterase inhibitory properties, tiapride (TIA).	Tiapride Hydrochloride	127-135	butyrylcholinesterase	Homo sapiens	89-103
16036766-5	2005	In the present paper the authors present their results using another benzamide with weak cholinesterase inhibitory properties, tiapride (TIA).	Tiapride Hydrochloride	137-140	butyrylcholinesterase	Homo sapiens	89-103
20981864-8	2011	Tiapride (IC50 = 256 micro m) and K-27 (IC50 = 414 micro m) only weakly inhibited RBC AChE activity.	Tiapride Hydrochloride	0-8	acetylcholinesterase	Rattus norvegicus	86-90
16479322-4	2006	We have shown previously that tiapride (TIA) is in vitro a weak inhibitor of AChE.	Tiapride Hydrochloride	30-38	acetylcholinesterase	Rattus norvegicus	77-81
16479322-4	2006	We have shown previously that tiapride (TIA) is in vitro a weak inhibitor of AChE.	Tiapride Hydrochloride	40-43	acetylcholinesterase	Rattus norvegicus	77-81
11692072-0	2001	Influence of the dopamine D2 receptor (DRD2) exon 8 genotype on efficacy of tiapride and clinical outcome of alcohol withdrawal.	Tiapride Hydrochloride	76-84	dopamine receptor D2	Homo sapiens	39-43
11692072-1	2001	We tested the hypothesis that allelic variants of the human dopamine D2 receptor E8 genotype are associated with (i) dopamine D2 antagonist tiapride dose in treatment of alcohol withdrawal (n = 50) and (ii) with anxiety and depression in patients during alcoholism detoxification therapy (admission n = 87; discharge n = 50).	Tiapride Hydrochloride	140-148	dopamine receptor D2	Homo sapiens	60-80
11692072-2	2001	DRD2 E8 A/A genotype was associated with increased dose of tiapride during a 9-day detoxification therapy and with increased anxiety and depression scores on admission and 2 weeks later.	Tiapride Hydrochloride	59-67	dopamine receptor D2	Homo sapiens	0-4
11692072-3	2001	The findings suggest a pharmacogenetic influence of DRD2 E8 genotype on tiapride efficacy in alcohol withdrawal.	Tiapride Hydrochloride	72-80	dopamine receptor D2	Homo sapiens	52-56
9264100-1	1997	Although the antiaggressive properties of several atypical neuroleptics are known, the actions of tiapride (a selective dopaminergic D2-receptor antagonist) on agonistic behavior have not been explored and there are no studies comparing acute and subchronic effects of this compound on aggression in rodents.	Tiapride Hydrochloride	98-106	dopamine receptor D2	Mus musculus	133-144
9353417-7	1997	In both the cerebral cortex and striatum, D4 receptor mRNA was upregulated by certain typical (chlorpromazine and haloperidol) and certain atypical (clozapine, olanzapine and risperidone) antipsychotic agents as well as by tiapride.	Tiapride Hydrochloride	223-231	dopamine receptor D4	Homo sapiens	42-53
9353417-9	1997	The finding that up-regulation of D2 dopamine receptor mRNAs was a consistently observed effect of a wide range of antipsychotic agents in the cerebral cortex but not in the neostriatum, coupled with the fact that the D2-short isoforms in the cortex were not regulated by a nonantipsychotic D2 antagonist, tiapride, draws attention to the importance of the D2 dopamine receptor in the cerebral cortex as a potentially critical, common site of action of antipsychotic medications.	Tiapride Hydrochloride	306-314	dopamine receptor D2	Homo sapiens	34-54
8241609-2	1993	Tiapride is a substituted benzamide derivative with selective dopamine D2-receptor antagonist properties which appears to have preferential affinity for extrastriatal dopamine receptors.	Tiapride Hydrochloride	0-8	dopamine receptor D2	Homo sapiens	62-82
7521826-2	1994	Tiapride, an atypical neuroleptic agent, is a selective dopamine D2-receptor antagonist with little propensity for causing catalepsy and sedation.	Tiapride Hydrochloride	0-8	dopamine receptor D2	Homo sapiens	56-76
34431014-15	2021	"Tiapride" upregulated the protein expression of GS and EAAT2, reduce Glu levels, increase gamma-GABA levels, and eventually improve amino acid neurotransmitter imbalance.	Tiapride Hydrochloride	1-9	solute carrier family 1 member 2	Rattus norvegicus	56-61