PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2894963-5	1988	Of the epicatechin derivatives, EGCG and ECG showed greater spectral change with oxidized P-450 and time- and concentration-dependent inhibition of the binding of carbon monoxide to dithionite-reduced cytochrome P-450.	epicatechin gallate	41-44	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	201-217
2463907-1	1989	To improve our knowledge of the structural features of the alpha-subunit of hCG we have studied the antigenic site recognized by monoclonal antibody (MAb) ECG01 raised against equine CG (eCG) which binds to hormones and alpha-subunits from human and equine species.	epicatechin gallate	187-190	hypertrichosis 2 (generalised, congenital)	Homo sapiens	76-79
2463907-1	1989	To improve our knowledge of the structural features of the alpha-subunit of hCG we have studied the antigenic site recognized by monoclonal antibody (MAb) ECG01 raised against equine CG (eCG) which binds to hormones and alpha-subunits from human and equine species.	epicatechin gallate	187-190	hypertrichosis 2 (generalised, congenital)	Homo sapiens	77-79
2894963-6	1988	The addition of EC, EGC, ECG, and EGCG to microsomes prepared from control, PB- or 3-methylcholanthrene-treated rats resulted in a dose-dependent inhibition of cytochrome P-450-dependent aryl hydrocarbon hydroxylase, 7-ethoxycoumarin O-deethylase, and 7-ethoxyresorufin O-deethylase activities.	epicatechin gallate	25-28	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	160-176
33856591-3	2021	Molecular docking study using BIOVIA Discovery Studio 2018 revealed, (-)-epicatechin-3-O-gallate (ECG), a tea polyphenol has a binding affinity toward both the selected receptors, with the lowest CDocker energy - 46.22 kcal mol-1 for SARS-CoV-2 Mpro and CDocker energy - 44.72 kcal mol-1 for SARS-CoV-2 PLpro, respectively.	epicatechin gallate	69-96	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	245-249
3807385-4	1986	It was found that orally administered (-)-epicatechin gallate and (-)-epigallocatechin gallate from tea leaves lowered the serum cholesterol level in mice fed a high fat emulsion.	epicatechin gallate	38-61	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	100-103
33856591-3	2021	Molecular docking study using BIOVIA Discovery Studio 2018 revealed, (-)-epicatechin-3-O-gallate (ECG), a tea polyphenol has a binding affinity toward both the selected receptors, with the lowest CDocker energy - 46.22 kcal mol-1 for SARS-CoV-2 Mpro and CDocker energy - 44.72 kcal mol-1 for SARS-CoV-2 PLpro, respectively.	epicatechin gallate	98-101	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	245-249
33856591-4	2021	The SARS-CoV-2 Mpro complexed with (-)-epicatechin-3-O-gallate, which had shown the best binding affinity was subjected to molecular dynamics simulations to validate its binding affinity, during which, the root-mean-square-deviation values of SARS-CoV-2 Mpro-Co-crystal ligand (N3) and SARS-CoV-2 Mpro- (-)-epicatechin-3-O-gallate systems were found to be more stable than SARS-CoV-2 Mpro system.	epicatechin gallate	35-62	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	15-19
33856591-4	2021	The SARS-CoV-2 Mpro complexed with (-)-epicatechin-3-O-gallate, which had shown the best binding affinity was subjected to molecular dynamics simulations to validate its binding affinity, during which, the root-mean-square-deviation values of SARS-CoV-2 Mpro-Co-crystal ligand (N3) and SARS-CoV-2 Mpro- (-)-epicatechin-3-O-gallate systems were found to be more stable than SARS-CoV-2 Mpro system.	epicatechin gallate	35-62	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	254-258
33856591-4	2021	The SARS-CoV-2 Mpro complexed with (-)-epicatechin-3-O-gallate, which had shown the best binding affinity was subjected to molecular dynamics simulations to validate its binding affinity, during which, the root-mean-square-deviation values of SARS-CoV-2 Mpro-Co-crystal ligand (N3) and SARS-CoV-2 Mpro- (-)-epicatechin-3-O-gallate systems were found to be more stable than SARS-CoV-2 Mpro system.	epicatechin gallate	35-62	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	254-258
33856591-4	2021	The SARS-CoV-2 Mpro complexed with (-)-epicatechin-3-O-gallate, which had shown the best binding affinity was subjected to molecular dynamics simulations to validate its binding affinity, during which, the root-mean-square-deviation values of SARS-CoV-2 Mpro-Co-crystal ligand (N3) and SARS-CoV-2 Mpro- (-)-epicatechin-3-O-gallate systems were found to be more stable than SARS-CoV-2 Mpro system.	epicatechin gallate	35-62	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	254-258
33856591-5	2021	Further, (-)-epicatechin-3-O-gallate was subjected to QSAR analysis which predicted IC50 of 0.3281 nM against SARS-CoV-2 Mpro.	epicatechin gallate	9-36	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	121-125
33856591-6	2021	Overall, (-)-epicatechin-3-O-gallate showed a potential binding affinity with SARS-CoV-2 Mpro and could be proposed as a potential natural compound for COVID-19 treatment.	epicatechin gallate	9-36	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	89-93
33137558-0	2020	Inhibition of Abeta aggregates in Alzheimer"s disease by epigallocatechin and epicatechin-3-gallate from green tea.	epicatechin gallate	78-99	amyloid beta (A4) precursor protein	Mus musculus	14-19
33667331-7	2021	Tea polyphenols epicatechin gallate (ECG) and epigallocatechin-3-gallate (EGCG), but not epicatechin or epigallocatechin, isoform-selectively hyperpolarized KCNQ5 activation voltage dependence.	epicatechin gallate	37-40	potassium voltage-gated channel subfamily Q member 5	Rattus norvegicus	157-162
33137558-6	2020	The results demonstrate that green tea catechins EGC and ECG are able to alleviate the toxicity of Abeta oligomers and fibrils.	epicatechin gallate	57-60	amyloid beta (A4) precursor protein	Mus musculus	99-104
33329667-6	2020	In vitro analysis with 10 available compounds showed that CAG, ECG, GCG, EGCG, and PB2 inhibited the Mpro activity with an IC50 value, 2.98 +- 0.21, 5.21 +- 0.5, 6.38 +- 0.5, 7.51 +- 0.21, and 75.3 +- 1.29 muM, respectively, while CA, EC, EGC, GC, and PA2 did not have inhibitory activities.	epicatechin gallate	63-66	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	101-105
33266280-6	2020	We observed that epigallocatechin, epigallocatechin gallate, epicatechin, and epicatechin gallate may decrease enzymatic activity of PTP1B phosphatase and viability of MCF-7 cells.	epicatechin gallate	78-97	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	133-138
33200674-5	2022	The protein-protein interaction network, QikProp, and molecular docking studies were performed to identify the lead compound that revealed Epicatechin Gallate (ECG) of COC as an effective inhibitor against candidate MI/apoptosis mediator - caspase 3.	epicatechin gallate	139-158	caspase 3	Homo sapiens	240-249
33200674-5	2022	The protein-protein interaction network, QikProp, and molecular docking studies were performed to identify the lead compound that revealed Epicatechin Gallate (ECG) of COC as an effective inhibitor against candidate MI/apoptosis mediator - caspase 3.	epicatechin gallate	160-163	caspase 3	Homo sapiens	240-249
32490491-1	2020	The inhibition mechanism of epicatechin gallate (ECG) on tyrosinase was investigated by multispectroscopic techniques combined with molecular docking and molecular dynamics simulation.	epicatechin gallate	28-47	tyrosinase	Homo sapiens	57-67
32454171-0	2020	Anti-melanogenic effects of epigallocatechin-3-gallate (EGCG), epicatechin-3-gallate (ECG) and gallocatechin-3-gallate (GCG) via down-regulation of cAMP/CREB /MITF signaling pathway in B16F10 melanoma cells.	epicatechin gallate	63-84	cAMP responsive element binding protein 1	Mus musculus	153-157
32454171-0	2020	Anti-melanogenic effects of epigallocatechin-3-gallate (EGCG), epicatechin-3-gallate (ECG) and gallocatechin-3-gallate (GCG) via down-regulation of cAMP/CREB /MITF signaling pathway in B16F10 melanoma cells.	epicatechin gallate	63-84	melanogenesis associated transcription factor	Mus musculus	159-163
32454171-2	2020	Previous studies have shown that gallocatechin-3-gallate (GCG), epigallocatechin-3-gallate (EGCG) and epicatechin-3-gallate (ECG) exerted strong inhibitory effects on mushroom tyrosinase activity in vitro, whilst EGCG inhibited melanogenesis in vivo, yet the underlying mechanisms are not entirely clear.	epicatechin gallate	102-123	tyrosinase	Mus musculus	176-186
32454171-2	2020	Previous studies have shown that gallocatechin-3-gallate (GCG), epigallocatechin-3-gallate (EGCG) and epicatechin-3-gallate (ECG) exerted strong inhibitory effects on mushroom tyrosinase activity in vitro, whilst EGCG inhibited melanogenesis in vivo, yet the underlying mechanisms are not entirely clear.	epicatechin gallate	125-128	tyrosinase	Mus musculus	176-186
32454171-4	2020	The results showed that the tea catechins significantly suppressed tyrosinase activity and melanin synthesis in B16F10 cells, where the effects of ECG > EGCG > GCG.	epicatechin gallate	147-150	tyrosinase	Mus musculus	67-77
32334376-7	2020	Besides, we demonstrated that the tea catechins epigallocatechin-3-gallate (EGCG) and epicatechin-3-gallate (ECG) are abundant in WTE and contribute to the regulation of cholesterol metabolism related genes, including LDLR, MTTP and APOB.	epicatechin gallate	86-107	low density lipoprotein receptor	Homo sapiens	218-222
32334376-7	2020	Besides, we demonstrated that the tea catechins epigallocatechin-3-gallate (EGCG) and epicatechin-3-gallate (ECG) are abundant in WTE and contribute to the regulation of cholesterol metabolism related genes, including LDLR, MTTP and APOB.	epicatechin gallate	86-107	microsomal triglyceride transfer protein	Homo sapiens	224-228
32334376-7	2020	Besides, we demonstrated that the tea catechins epigallocatechin-3-gallate (EGCG) and epicatechin-3-gallate (ECG) are abundant in WTE and contribute to the regulation of cholesterol metabolism related genes, including LDLR, MTTP and APOB.	epicatechin gallate	86-107	apolipoprotein B	Homo sapiens	233-237
32334376-7	2020	Besides, we demonstrated that the tea catechins epigallocatechin-3-gallate (EGCG) and epicatechin-3-gallate (ECG) are abundant in WTE and contribute to the regulation of cholesterol metabolism related genes, including LDLR, MTTP and APOB.	epicatechin gallate	109-112	low density lipoprotein receptor	Homo sapiens	218-222
32334376-7	2020	Besides, we demonstrated that the tea catechins epigallocatechin-3-gallate (EGCG) and epicatechin-3-gallate (ECG) are abundant in WTE and contribute to the regulation of cholesterol metabolism related genes, including LDLR, MTTP and APOB.	epicatechin gallate	109-112	microsomal triglyceride transfer protein	Homo sapiens	224-228
32334376-7	2020	Besides, we demonstrated that the tea catechins epigallocatechin-3-gallate (EGCG) and epicatechin-3-gallate (ECG) are abundant in WTE and contribute to the regulation of cholesterol metabolism related genes, including LDLR, MTTP and APOB.	epicatechin gallate	109-112	apolipoprotein B	Homo sapiens	233-237
32490491-1	2020	The inhibition mechanism of epicatechin gallate (ECG) on tyrosinase was investigated by multispectroscopic techniques combined with molecular docking and molecular dynamics simulation.	epicatechin gallate	49-52	tyrosinase	Homo sapiens	57-67
30477461-4	2018	The binding interaction of flavonoids (theaflavin, quercetin, rutin, epicatechin 3 gallate and tamarixetin) with GSK 3beta was determined by molecular docking.	epicatechin gallate	69-90	glycogen synthase kinase 3 beta	Homo sapiens	113-122
32217102-0	2020	The inhibitory effect of ECG and EGCG dimeric procyanidins on colorectal cancer cells growth is associated with their actions at lipid rafts and the inhibition of the epidermal growth factor receptor signaling.	epicatechin gallate	25-28	epidermal growth factor receptor	Homo sapiens	167-199
32217102-6	2020	In addition, ECG and EGCG dimers inhibited cell migration, invasion, and adhesion, decreasing the activity of matrix metalloproteinases (MMP-2/9).	epicatechin gallate	13-16	matrix metallopeptidase 2	Homo sapiens	137-144
32217102-7	2020	Mechanistically, ECG and EGCG dimers inhibited the activation of lipid raft-associated epidermal growth factor (EGF) receptor (EGFR), without affecting its localization at lipid rafts.	epicatechin gallate	17-20	epidermal growth factor receptor	Homo sapiens	87-125
32217102-7	2020	Mechanistically, ECG and EGCG dimers inhibited the activation of lipid raft-associated epidermal growth factor (EGF) receptor (EGFR), without affecting its localization at lipid rafts.	epicatechin gallate	17-20	epidermal growth factor receptor	Homo sapiens	127-131
32217102-8	2020	In particular, ECG and EGCG dimers reduced EGFR phosphorylation at Tyr1068 residue, prevented EGFR dimerization and activation upon stimulation, and induced EGFR internalization both in the absence and presence of EGF.	epicatechin gallate	15-18	epidermal growth factor receptor	Homo sapiens	43-47
32217102-8	2020	In particular, ECG and EGCG dimers reduced EGFR phosphorylation at Tyr1068 residue, prevented EGFR dimerization and activation upon stimulation, and induced EGFR internalization both in the absence and presence of EGF.	epicatechin gallate	15-18	epidermal growth factor receptor	Homo sapiens	94-98
32217102-8	2020	In particular, ECG and EGCG dimers reduced EGFR phosphorylation at Tyr1068 residue, prevented EGFR dimerization and activation upon stimulation, and induced EGFR internalization both in the absence and presence of EGF.	epicatechin gallate	15-18	epidermal growth factor receptor	Homo sapiens	94-98
32217102-9	2020	Furthermore, ECG and EGCG dimers increased EGFR phosphorylation at Tyr1045 residue, providing a docking site for ubiquitin ligase c-Cbl and induced EGFR degradation by the proteasome.	epicatechin gallate	13-16	epidermal growth factor receptor	Homo sapiens	43-47
32217102-9	2020	Furthermore, ECG and EGCG dimers increased EGFR phosphorylation at Tyr1045 residue, providing a docking site for ubiquitin ligase c-Cbl and induced EGFR degradation by the proteasome.	epicatechin gallate	13-16	Cbl proto-oncogene	Homo sapiens	130-135
32217102-9	2020	Furthermore, ECG and EGCG dimers increased EGFR phosphorylation at Tyr1045 residue, providing a docking site for ubiquitin ligase c-Cbl and induced EGFR degradation by the proteasome.	epicatechin gallate	13-16	epidermal growth factor receptor	Homo sapiens	148-152
32217102-10	2020	Downstream of EGFR, ECG and EGCG dimers inhibited the activation of the MEK/ERK1/2 and PI3K/AKT signaling pathways, downregulating proteins involved in the modulation of cell survival.	epicatechin gallate	20-23	mitogen-activated protein kinase kinase 7	Homo sapiens	72-75
32217102-10	2020	Downstream of EGFR, ECG and EGCG dimers inhibited the activation of the MEK/ERK1/2 and PI3K/AKT signaling pathways, downregulating proteins involved in the modulation of cell survival.	epicatechin gallate	20-23	mitogen-activated protein kinase 3	Homo sapiens	76-82
32217102-10	2020	Downstream of EGFR, ECG and EGCG dimers inhibited the activation of the MEK/ERK1/2 and PI3K/AKT signaling pathways, downregulating proteins involved in the modulation of cell survival.	epicatechin gallate	20-23	AKT serine/threonine kinase 1	Homo sapiens	92-95
32217102-11	2020	In conclusion, ECG and EGCG dimers reduced CRC cell growth by inhibiting EGFR activation at multiple steps, including the disruption of lipid rafts integrity and promoting EGFR degradation.	epicatechin gallate	15-18	epidermal growth factor receptor	Homo sapiens	73-77
32217102-11	2020	In conclusion, ECG and EGCG dimers reduced CRC cell growth by inhibiting EGFR activation at multiple steps, including the disruption of lipid rafts integrity and promoting EGFR degradation.	epicatechin gallate	15-18	epidermal growth factor receptor	Homo sapiens	172-176
31582423-2	2019	Akin to ouabain, an archetypal Na/K-ATPase ligand of the cardiotonic steroids (CTS) family, ECG also activates PKCe translocation and increases the force of contraction of the rat heart.	epicatechin gallate	92-95	protein kinase C, epsilon	Rattus norvegicus	111-115
31582423-3	2019	This study evaluated whether, like ouabain, ECG also modulates Na/K-ATPase/Src receptor function and triggers pre- and post-conditioning against ischemia/reperfusion (I/R) injury.	epicatechin gallate	44-47	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	75-78
31582423-4	2019	In vitro, ECG activated the purified Na/K-ATPase/Src complex.	epicatechin gallate	10-13	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	49-52
31582423-6	2019	ECG protection was blocked by PKCe inhibition and attenuated by mitochondrial KATP channel inhibition.	epicatechin gallate	0-3	protein kinase C epsilon	Homo sapiens	30-34
31582423-7	2019	In a unique mammalian cell system with depleted Na/K-ATPase alpha1 expression, ECG-induced PKCe activation persisted but protection against I/R was blunted.	epicatechin gallate	79-82	protein kinase C epsilon	Homo sapiens	91-95
31582423-8	2019	Taken together, these results reveal a Na/K-ATPase- and PKCe-dependent mechanism of protection by ECG that is also distinct from the mechanism of action of ouabain.	epicatechin gallate	98-101	protein kinase C epsilon	Homo sapiens	56-60
31582423-13	2019	This study provides experimental evidence that ECG concentrations commonly detected in human after consumption of a cup of tea trigger Na/K-ATPase/Src receptor in a cell-free system, activate a CTS-like signaling pathway, and provide PKCepsilon-dependent protection against ischemia/reperfusion injury in rat hearts.	epicatechin gallate	47-50	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	147-150
31582423-13	2019	This study provides experimental evidence that ECG concentrations commonly detected in human after consumption of a cup of tea trigger Na/K-ATPase/Src receptor in a cell-free system, activate a CTS-like signaling pathway, and provide PKCepsilon-dependent protection against ischemia/reperfusion injury in rat hearts.	epicatechin gallate	47-50	protein kinase C epsilon	Homo sapiens	234-244
30660780-3	2019	Among the isolates, three tea polyphenols, including (-)-catechin gallate (CG), (-)-epicatechin gallate (ECG), and (-)-epigallocatechin gallate (EGCG), significantly decreased Abeta aggregation at a concentration of 10 mug ml-1, compared to the positive control, Abeta alone.	epicatechin gallate	80-103	amyloid beta precursor protein	Homo sapiens	176-181
30847127-7	2019	Statistically significant up-regulation of MUC17 was observed following incubation with epicatechin gallate and quercetin.	epicatechin gallate	88-107	mucin 17, cell surface associated	Homo sapiens	43-48
32568613-8	2021	However, only three polyphenols (epigallocatechin gallate, epicatechingallate and gallocatechin-3-gallate) interact strongly with one or both catalytic residues (His41 and Cys145) of Mpro.	epicatechin gallate	59-77	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	183-187
31393601-5	2019	RESULTS: Epicatechin gallate (ECG), epigallocatechin gallate (EGCG), quercetin (QUER), and myricetin (MYR) caused a significant decrease in plasmin activity by 60, 86, 65, and 90%, respectively.	epicatechin gallate	9-28	plasminogen	Homo sapiens	140-147
31393601-5	2019	RESULTS: Epicatechin gallate (ECG), epigallocatechin gallate (EGCG), quercetin (QUER), and myricetin (MYR) caused a significant decrease in plasmin activity by 60, 86, 65, and 90%, respectively.	epicatechin gallate	30-33	plasminogen	Homo sapiens	140-147
31393601-8	2019	A decrease in the random structure of plasmin upon the complex formation with ECG, EGCG, QUER, and MYR was found.	epicatechin gallate	78-81	plasminogen	Homo sapiens	38-45
31393601-12	2019	CONCLUSION: Significant changes in the secondary structure of plasmin upon binding of ECG, EGCG, QUER, and MYR led to diminished plasmin activity both in the absence and presence of milk proteins.	epicatechin gallate	86-89	plasminogen	Homo sapiens	62-69
31393601-12	2019	CONCLUSION: Significant changes in the secondary structure of plasmin upon binding of ECG, EGCG, QUER, and MYR led to diminished plasmin activity both in the absence and presence of milk proteins.	epicatechin gallate	86-89	plasminogen	Homo sapiens	129-136
30101645-0	2019	Effect of (-)-epicatechin-3-gallate and (-)-epigallocatechin-3-gallate on the binding of tegafur to human serum albumin as determined by spectroscopy, isothermal titration calorimetry, and molecular docking.	epicatechin gallate	10-35	albumin	Homo sapiens	106-119
30983343-7	2019	Moreover, the expression of multi-drug resistance protein 2 (MRP2) after 3 h of incubation with either 50 muM EGCG or 50 muM EC was elevated by 1.58- and 2.98-fold, respectively, while 50 muM ECG had no significantly effects.	epicatechin gallate	192-195	ATP binding cassette subfamily C member 2	Homo sapiens	28-59
30983343-7	2019	Moreover, the expression of multi-drug resistance protein 2 (MRP2) after 3 h of incubation with either 50 muM EGCG or 50 muM EC was elevated by 1.58- and 2.98-fold, respectively, while 50 muM ECG had no significantly effects.	epicatechin gallate	192-195	ATP binding cassette subfamily C member 2	Homo sapiens	61-65
30983343-8	2019	In addition, the expression of P-glycoprotein (P-gp) after treatment with either 50 muM EGCG, 50 muM ECG, or 50 muM EC was enhanced by 1.53-, 1.63-, and 1.80-fold, respectively.	epicatechin gallate	101-104	ATP binding cassette subfamily B member 1	Homo sapiens	31-45
30983343-8	2019	In addition, the expression of P-glycoprotein (P-gp) after treatment with either 50 muM EGCG, 50 muM ECG, or 50 muM EC was enhanced by 1.53-, 1.63-, and 1.80-fold, respectively.	epicatechin gallate	101-104	ATP binding cassette subfamily B member 1	Homo sapiens	47-51
29964016-4	2018	Among the 35 members of Tas2r family, Tas2r108, 110, 113, 125, and 144 responded to ECg.	epicatechin gallate	84-87	taste receptor, type 2, member 108	Mus musculus	38-46
30149692-6	2018	Furthermore, a high-throughput screening method was successfully established by our probe, and a potent natural inhibitor of GLU was identified as (-)-epicatechin-3-gallate (ECG) for effectively preventing NSAIDs-inducing enteropathy in vivo.	epicatechin gallate	147-172	glucuronidase beta	Homo sapiens	125-128
30149692-6	2018	Furthermore, a high-throughput screening method was successfully established by our probe, and a potent natural inhibitor of GLU was identified as (-)-epicatechin-3-gallate (ECG) for effectively preventing NSAIDs-inducing enteropathy in vivo.	epicatechin gallate	174-177	glucuronidase beta	Homo sapiens	125-128
29336809-7	2018	By taking the advantage of the screening method, luteolin and epicatechin gallate were discovered as the new BCR-ABL inhibitors.	epicatechin gallate	62-81	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	109-116
29732583-12	2018	ECG produced a significant (p < .001) reduction in plasma PGE2 (by 27, 38, and 50%), TNF-alpha (15, 33, and 41%), IL-1beta (17, 25, and 33%), and IL-6 (22, 32, and 43%), at the tested doses, respectively.	epicatechin gallate	0-3	tumor necrosis factor	Mus musculus	88-97
29732583-12	2018	ECG produced a significant (p < .001) reduction in plasma PGE2 (by 27, 38, and 50%), TNF-alpha (15, 33, and 41%), IL-1beta (17, 25, and 33%), and IL-6 (22, 32, and 43%), at the tested doses, respectively.	epicatechin gallate	0-3	interleukin 6	Mus musculus	149-153
29759183-6	2018	The results showed that ECG and EGCG had good THR inhibition activity and their inhibition rates at concentration of 200 mumol/L were 53.2 +- 3.8% and 55.8 +- 2.6%, respectively, which was in consistent with the results of microplate reader assay.	epicatechin gallate	24-27	coagulation factor II, thrombin	Homo sapiens	46-49
29759183-7	2018	Additionally, molecular docking results showed that the benzopyran groups of ECG and EGCG were inserted into the THR active pocket and interacted with residues LYS60F, TRP60D, TRY60A, IEU99, GLY216, HIS57 and SER195, but EC and EGC did not.	epicatechin gallate	77-80	coagulation factor II, thrombin	Homo sapiens	113-116
29732583-12	2018	ECG produced a significant (p < .001) reduction in plasma PGE2 (by 27, 38, and 50%), TNF-alpha (15, 33, and 41%), IL-1beta (17, 25, and 33%), and IL-6 (22, 32, and 43%), at the tested doses, respectively.	epicatechin gallate	0-3	interleukin 1 beta	Mus musculus	117-125
29744906-5	2018	Four components in green tea showed alpha-glucosidase inhibition action and three of them were identified as HHDP-galloyl glucose, (-)-epigallocatechin-3-gallate and (-)-epicatechin-3-gallate by HPLC-fourier-transform mass spectrometry (HPLC-FTMS).	epicatechin gallate	166-191	sucrase-isomaltase	Homo sapiens	36-53
28545670-11	2017	The mRNA levels of IFN-alpha, IFN-lambda, TNF-alpha, Mx, and ZAP were upregulated in RAW 264.7 cells pre-treated with fisetin, quercetin, and daidzein, but not in those pre-treated with EGCG or ECG.	epicatechin gallate	194-197	interferon alpha	Mus musculus	19-28
28546002-4	2017	We found that (-)-epicatechin gallate (ECG) and (-)-epigallocatechin-3-gallate (EGCG) activate satellite cells by induction of Myf5 transcription factors.	epicatechin gallate	14-37	myogenic factor 5	Mus musculus	127-131
28546002-4	2017	We found that (-)-epicatechin gallate (ECG) and (-)-epigallocatechin-3-gallate (EGCG) activate satellite cells by induction of Myf5 transcription factors.	epicatechin gallate	39-42	myogenic factor 5	Mus musculus	127-131
28546002-5	2017	For satellite cell activation, Akt kinase was significantly induced after ECG treatment and ECG-induced satellite cell activation was blocked in the presence of Akt inhibitor.	epicatechin gallate	74-77	thymoma viral proto-oncogene 1	Mus musculus	31-34
28546002-5	2017	For satellite cell activation, Akt kinase was significantly induced after ECG treatment and ECG-induced satellite cell activation was blocked in the presence of Akt inhibitor.	epicatechin gallate	74-77	thymoma viral proto-oncogene 1	Mus musculus	161-164
28546002-5	2017	For satellite cell activation, Akt kinase was significantly induced after ECG treatment and ECG-induced satellite cell activation was blocked in the presence of Akt inhibitor.	epicatechin gallate	92-95	thymoma viral proto-oncogene 1	Mus musculus	161-164
28546002-6	2017	ECG also promotes myogenic differentiation through the induction of myogenic markers, including Myogenin and Muscle creatine kinase (MCK), in satellite and C2C12 myoblast cells.	epicatechin gallate	0-3	myogenin	Mus musculus	96-104
28546002-6	2017	ECG also promotes myogenic differentiation through the induction of myogenic markers, including Myogenin and Muscle creatine kinase (MCK), in satellite and C2C12 myoblast cells.	epicatechin gallate	0-3	creatine kinase, muscle	Mus musculus	109-131
28546002-6	2017	ECG also promotes myogenic differentiation through the induction of myogenic markers, including Myogenin and Muscle creatine kinase (MCK), in satellite and C2C12 myoblast cells.	epicatechin gallate	0-3	creatine kinase, muscle	Mus musculus	133-136
28740135-6	2017	The mutated proteins exhibit kinetic properties similar to the wild-type transporter and are inhibited by established GLUT5 inhibitors N-[4-(methylsulfonyl)-2-nitrophenyl]-1,3-benzodioxol-5-amine (MSNBA) and (-)-epicatechin-gallate (ECG).	epicatechin gallate	208-231	solute carrier family 2 member 5	Homo sapiens	118-123
28740135-6	2017	The mutated proteins exhibit kinetic properties similar to the wild-type transporter and are inhibited by established GLUT5 inhibitors N-[4-(methylsulfonyl)-2-nitrophenyl]-1,3-benzodioxol-5-amine (MSNBA) and (-)-epicatechin-gallate (ECG).	epicatechin gallate	233-236	solute carrier family 2 member 5	Homo sapiens	118-123
28545670-11	2017	The mRNA levels of IFN-alpha, IFN-lambda, TNF-alpha, Mx, and ZAP were upregulated in RAW 264.7 cells pre-treated with fisetin, quercetin, and daidzein, but not in those pre-treated with EGCG or ECG.	epicatechin gallate	194-197	tumor necrosis factor	Mus musculus	42-51
28545670-11	2017	The mRNA levels of IFN-alpha, IFN-lambda, TNF-alpha, Mx, and ZAP were upregulated in RAW 264.7 cells pre-treated with fisetin, quercetin, and daidzein, but not in those pre-treated with EGCG or ECG.	epicatechin gallate	194-197	zinc finger CCCH type, antiviral 1	Mus musculus	61-64
26201055-8	2015	Compounds (-)-epicatechin-3-O-gallate, 1,2,3,6-tetra-O-galloyl-ss-D-glucose and gallocatechin-3-O-gallate showed tyrosinase inhibitions with the IC50 values of 27.52, 83.30 and 28.30 microg/mL, respectively.	epicatechin gallate	10-37	tyrosinase	Mus musculus	113-123
27224248-0	2016	Epicatechin-3-gallate reverses TGF-beta1-induced epithelial-to-mesenchymal transition and inhibits cell invasion and protease activities in human lung cancer cells.	epicatechin gallate	0-21	transforming growth factor beta 1	Homo sapiens	31-40
27224248-11	2016	ECG may also be administered as an effective chemopreventive agent against TGF-beta1-induced EMT.	epicatechin gallate	0-3	transforming growth factor beta 1	Homo sapiens	75-84
26878775-0	2016	Directly interact with Keap1 and LPS is involved in the anti-inflammatory mechanisms of (-)-epicatechin-3-gallate in LPS-induced macrophages and endotoxemia.	epicatechin gallate	88-113	kelch like ECH associated protein 1	Homo sapiens	23-28
26878775-4	2016	ECG attenuated lipopolysaccharide (LPS)-induced inflammatory mediator expression and intracellular reactive oxygen species (ROS) generation through the induction of Nrf2/antioxidant response element (ARE)-driven glutathione (GSH) and hemeoxygenase-1 (HO-1) levels, interference with NF-kappaB and Nfr2/ARE transcriptional activities, and suppression of the MAPKs (JNK1/2 and p38) and PI3K/Akt signaling pathways.	epicatechin gallate	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	165-169
26878775-4	2016	ECG attenuated lipopolysaccharide (LPS)-induced inflammatory mediator expression and intracellular reactive oxygen species (ROS) generation through the induction of Nrf2/antioxidant response element (ARE)-driven glutathione (GSH) and hemeoxygenase-1 (HO-1) levels, interference with NF-kappaB and Nfr2/ARE transcriptional activities, and suppression of the MAPKs (JNK1/2 and p38) and PI3K/Akt signaling pathways.	epicatechin gallate	0-3	heme oxygenase 1	Homo sapiens	234-255
26878775-4	2016	ECG attenuated lipopolysaccharide (LPS)-induced inflammatory mediator expression and intracellular reactive oxygen species (ROS) generation through the induction of Nrf2/antioxidant response element (ARE)-driven glutathione (GSH) and hemeoxygenase-1 (HO-1) levels, interference with NF-kappaB and Nfr2/ARE transcriptional activities, and suppression of the MAPKs (JNK1/2 and p38) and PI3K/Akt signaling pathways.	epicatechin gallate	0-3	nuclear factor kappa B subunit 1	Homo sapiens	283-292
26878775-4	2016	ECG attenuated lipopolysaccharide (LPS)-induced inflammatory mediator expression and intracellular reactive oxygen species (ROS) generation through the induction of Nrf2/antioxidant response element (ARE)-driven glutathione (GSH) and hemeoxygenase-1 (HO-1) levels, interference with NF-kappaB and Nfr2/ARE transcriptional activities, and suppression of the MAPKs (JNK1/2 and p38) and PI3K/Akt signaling pathways.	epicatechin gallate	0-3	mitogen-activated protein kinase 8	Homo sapiens	364-370
26878775-4	2016	ECG attenuated lipopolysaccharide (LPS)-induced inflammatory mediator expression and intracellular reactive oxygen species (ROS) generation through the induction of Nrf2/antioxidant response element (ARE)-driven glutathione (GSH) and hemeoxygenase-1 (HO-1) levels, interference with NF-kappaB and Nfr2/ARE transcriptional activities, and suppression of the MAPKs (JNK1/2 and p38) and PI3K/Akt signaling pathways.	epicatechin gallate	0-3	mitogen-activated protein kinase 1	Homo sapiens	375-378
28911555-8	2016	The abundance of phenylethyl alcohol was positively related to the content of ECG and EGCG during fermentation, whereas the abundance of cis-3-hexenal was negatively related to the content of ECG.	epicatechin gallate	192-195	suppressor of cytokine signaling 3	Homo sapiens	137-142
24879560-1	2014	In the present study, we found that three enzymes, MVK, MDD and FPPS, in the mevalonate pathway (MVP) of cholesterol biosynthesis, can be simultaneously inhibited by two green tea polyphenols ((-)-epicatechin-3-gallate, ECG; (-)-epigallocatechin-3-gallate, EGCG).	epicatechin gallate	193-218	mevalonate kinase	Homo sapiens	51-54
26855680-4	2016	Epicatechin gallate (EGCG) significantly sensitizes MCF-7/TAM cells to tamoxifen and dramatically reduced Nrf2 expression at both the messenger RNA and protein, leading to a reduction of Nrf2-downstream genes.	epicatechin gallate	0-19	NFE2 like bZIP transcription factor 2	Homo sapiens	106-110
26855680-4	2016	Epicatechin gallate (EGCG) significantly sensitizes MCF-7/TAM cells to tamoxifen and dramatically reduced Nrf2 expression at both the messenger RNA and protein, leading to a reduction of Nrf2-downstream genes.	epicatechin gallate	0-19	NFE2 like bZIP transcription factor 2	Homo sapiens	187-191
24847951-3	2015	HDPC pre-treated with catechins, epigallocatechin-3-gallate (EGCG) or epicatechin gallate (ECG), were exposed to lipopolysaccharide (LPS), peptidoglycan (PG), interlukin-1beta (IL-1beta) or tumour necrosis factor-alpha (TNF-alpha).	epicatechin gallate	70-89	decapping mRNA 2	Homo sapiens	0-4
24847951-3	2015	HDPC pre-treated with catechins, epigallocatechin-3-gallate (EGCG) or epicatechin gallate (ECG), were exposed to lipopolysaccharide (LPS), peptidoglycan (PG), interlukin-1beta (IL-1beta) or tumour necrosis factor-alpha (TNF-alpha).	epicatechin gallate	91-94	decapping mRNA 2	Homo sapiens	0-4
24847951-5	2015	RESULTS: EGCG and ECG significantly reduced LPS- or PG-mediated VEGF production in the HDPC in a dose-dependent manner.	epicatechin gallate	18-21	vascular endothelial growth factor A	Homo sapiens	64-68
24847951-5	2015	RESULTS: EGCG and ECG significantly reduced LPS- or PG-mediated VEGF production in the HDPC in a dose-dependent manner.	epicatechin gallate	18-21	decapping mRNA 2	Homo sapiens	87-91
24847951-9	2015	CONCLUSIONS: The up-regulated VEGF and COX-2 expressions in the HDPC stimulated with these bacteria-derived factors or IL-1beta were diminished by the treatment of EGCG and ECG.	epicatechin gallate	173-176	vascular endothelial growth factor A	Homo sapiens	30-34
24847951-9	2015	CONCLUSIONS: The up-regulated VEGF and COX-2 expressions in the HDPC stimulated with these bacteria-derived factors or IL-1beta were diminished by the treatment of EGCG and ECG.	epicatechin gallate	173-176	prostaglandin-endoperoxide synthase 2	Homo sapiens	39-44
24847951-9	2015	CONCLUSIONS: The up-regulated VEGF and COX-2 expressions in the HDPC stimulated with these bacteria-derived factors or IL-1beta were diminished by the treatment of EGCG and ECG.	epicatechin gallate	173-176	decapping mRNA 2	Homo sapiens	64-68
24847951-9	2015	CONCLUSIONS: The up-regulated VEGF and COX-2 expressions in the HDPC stimulated with these bacteria-derived factors or IL-1beta were diminished by the treatment of EGCG and ECG.	epicatechin gallate	173-176	interleukin 1 beta	Homo sapiens	119-127
25365042-2	2014	It was observed that EGCG analogs inhibited PL activity, and their inhibitory rates decreased by the order of EGCG>GCG>ECG>EC.	epicatechin gallate	125-128	pancreatic lipase	Homo sapiens	44-46
25365042-4	2014	alpha-Helix content of PL secondary structure decreased dependent on EGCG analogs concentration by the order of EGCG>GCG>ECG>EC.	epicatechin gallate	127-130	pancreatic lipase	Homo sapiens	23-25
25365042-5	2014	EGCG, ECG, and EC could quench PL fluorescence both dynamically and statically, while GCG only quenched statically.	epicatechin gallate	6-9	pancreatic lipase	Homo sapiens	31-33
26063620-3	2015	The Bax/Bcl-2 ratio increased significantly after 1 h pretreatment with ECG.	epicatechin gallate	72-75	BCL2 associated X, apoptosis regulator	Rattus norvegicus	4-7
26063620-3	2015	The Bax/Bcl-2 ratio increased significantly after 1 h pretreatment with ECG.	epicatechin gallate	72-75	BCL2, apoptosis regulator	Rattus norvegicus	8-13
26003087-7	2015	Epicatechin-3-gallate, an inhibitor of IL-1beta and CXCL10, at least partially reversed the elevated cytokine and chemokine levels, reduced seizure frequency, and prolonged survival of Tsc1(GFAP)CKO mice.	epicatechin gallate	0-21	interleukin 1 alpha	Mus musculus	39-47
26003087-7	2015	Epicatechin-3-gallate, an inhibitor of IL-1beta and CXCL10, at least partially reversed the elevated cytokine and chemokine levels, reduced seizure frequency, and prolonged survival of Tsc1(GFAP)CKO mice.	epicatechin gallate	0-21	chemokine (C-X-C motif) ligand 10	Mus musculus	52-58
26003087-7	2015	Epicatechin-3-gallate, an inhibitor of IL-1beta and CXCL10, at least partially reversed the elevated cytokine and chemokine levels, reduced seizure frequency, and prolonged survival of Tsc1(GFAP)CKO mice.	epicatechin gallate	0-21	TSC complex subunit 1	Mus musculus	185-189
26003087-7	2015	Epicatechin-3-gallate, an inhibitor of IL-1beta and CXCL10, at least partially reversed the elevated cytokine and chemokine levels, reduced seizure frequency, and prolonged survival of Tsc1(GFAP)CKO mice.	epicatechin gallate	0-21	glial fibrillary acidic protein	Mus musculus	190-194
25747701-12	2015	CFTR Cl- channel is a molecular target of natural compounds EGCG and ECG.	epicatechin gallate	69-72	CF transmembrane conductance regulator	Rattus norvegicus	0-4
25910046-1	2015	The molecular basis for the antiviral inhibitory properties of three catechins epigallocatechin gallate, epicatechin gallate and catechin-5-gallate derived from green tea was assessed in terms of their ability to interact with influenza neuraminidase.	epicatechin gallate	105-124	neuraminidase 1	Homo sapiens	237-250
24879560-1	2014	In the present study, we found that three enzymes, MVK, MDD and FPPS, in the mevalonate pathway (MVP) of cholesterol biosynthesis, can be simultaneously inhibited by two green tea polyphenols ((-)-epicatechin-3-gallate, ECG; (-)-epigallocatechin-3-gallate, EGCG).	epicatechin gallate	193-218	farnesyl diphosphate synthase	Homo sapiens	64-68
24721612-8	2014	EGCG, ECG, GCG and CG significantly lowered biodegradation rates and inhibited both MMP-9 and CT-B at a concentration of 0.65%.	epicatechin gallate	6-9	matrix metallopeptidase 9	Homo sapiens	84-89
25025898-3	2014	Fluorimetrically determined binding constants for (-)-epigallocatechin gallate (EGCG) and (-)-epicatechin gallate (ECG) with catalase were observed to be 2.27x106 M(-1) and 1.66x106 M(-1), respectively.	epicatechin gallate	90-113	catalase	Homo sapiens	125-133
25025898-3	2014	Fluorimetrically determined binding constants for (-)-epigallocatechin gallate (EGCG) and (-)-epicatechin gallate (ECG) with catalase were observed to be 2.27x106 M(-1) and 1.66x106 M(-1), respectively.	epicatechin gallate	115-118	catalase	Homo sapiens	125-133
24721612-8	2014	EGCG, ECG, GCG and CG significantly lowered biodegradation rates and inhibited both MMP-9 and CT-B at a concentration of 0.65%.	epicatechin gallate	6-9	phosphate cytidylyltransferase 1B, choline	Homo sapiens	94-98
24720993-6	2014	It was found that flavonols (quercetin and myricetin) and flavans (epicatechin gallate (ECG) and epigallocatechin (EGC)) showed higher TOD inhibitory activity than flavones and flavanones.	epicatechin gallate	67-86	monoamine oxidase B	Homo sapiens	135-138
24720993-6	2014	It was found that flavonols (quercetin and myricetin) and flavans (epicatechin gallate (ECG) and epigallocatechin (EGC)) showed higher TOD inhibitory activity than flavones and flavanones.	epicatechin gallate	88-91	monoamine oxidase B	Homo sapiens	135-138
24515112-0	2014	(-)-Epicatechin gallate (ECG) stimulates osteoblast differentiation via Runt-related transcription factor 2 (RUNX2) and transcriptional coactivator with PDZ-binding motif (TAZ)-mediated transcriptional activation.	epicatechin gallate	0-23	RUNX family transcription factor 2	Homo sapiens	72-107
24722342-4	2014	Fourteen flavanones were investigated for their potential to reduce activation of hTAS2R39 by epicatechin gallate (ECG), one of the main bitter compounds occurring in green tea.	epicatechin gallate	94-113	taste 2 receptor member 39	Homo sapiens	82-90
24722342-4	2014	Fourteen flavanones were investigated for their potential to reduce activation of hTAS2R39 by epicatechin gallate (ECG), one of the main bitter compounds occurring in green tea.	epicatechin gallate	115-118	taste 2 receptor member 39	Homo sapiens	82-90
24722342-5	2014	Three flavanones showed inhibitory behavior towards the activation of hTAS2R39 by ECG: 4"-fluoro-6-methoxyflavanone, 6,3"-dimethoxyflavanone, and 6-methoxyflavanone (in order of decreasing potency).	epicatechin gallate	82-85	taste 2 receptor member 39	Homo sapiens	70-78
24515112-0	2014	(-)-Epicatechin gallate (ECG) stimulates osteoblast differentiation via Runt-related transcription factor 2 (RUNX2) and transcriptional coactivator with PDZ-binding motif (TAZ)-mediated transcriptional activation.	epicatechin gallate	0-23	RUNX family transcription factor 2	Homo sapiens	109-114
24515112-0	2014	(-)-Epicatechin gallate (ECG) stimulates osteoblast differentiation via Runt-related transcription factor 2 (RUNX2) and transcriptional coactivator with PDZ-binding motif (TAZ)-mediated transcriptional activation.	epicatechin gallate	25-28	RUNX family transcription factor 2	Homo sapiens	72-107
24515112-0	2014	(-)-Epicatechin gallate (ECG) stimulates osteoblast differentiation via Runt-related transcription factor 2 (RUNX2) and transcriptional coactivator with PDZ-binding motif (TAZ)-mediated transcriptional activation.	epicatechin gallate	25-28	RUNX family transcription factor 2	Homo sapiens	109-114
23567286-5	2013	The most potent catalase inhibitors among the tested flavonoids have appeared myricetin, epicatechin gallate and epigallocatechin gallate.	epicatechin gallate	89-108	catalase	Bos taurus	16-24
23594085-8	2013	Interestingly, ECG inhibited the activity of transketolase and glucose-6-phosphate dehydrogenase, the key enzymes of the pentose phosphate pathway.	epicatechin gallate	15-18	transketolase	Homo sapiens	45-58
23840454-6	2013	Interestingly, EGCG, EGC and ECG showed the inhibition of FLT3 expression in cell lines harboring FLT3 mutations.	epicatechin gallate	29-32	fms related receptor tyrosine kinase 3	Homo sapiens	58-62
23840454-6	2013	Interestingly, EGCG, EGC and ECG showed the inhibition of FLT3 expression in cell lines harboring FLT3 mutations.	epicatechin gallate	29-32	fms related receptor tyrosine kinase 3	Homo sapiens	98-102
23840454-8	2013	Moreover, EGCG-, EGC-and ECG-treated cells showed the suppression of MAPK, AKT and STAT5 phosphorylation.	epicatechin gallate	25-28	AKT serine/threonine kinase 1	Homo sapiens	75-78
23840454-8	2013	Moreover, EGCG-, EGC-and ECG-treated cells showed the suppression of MAPK, AKT and STAT5 phosphorylation.	epicatechin gallate	25-28	signal transducer and activator of transcription 5A	Homo sapiens	83-88
23594085-8	2013	Interestingly, ECG inhibited the activity of transketolase and glucose-6-phosphate dehydrogenase, the key enzymes of the pentose phosphate pathway.	epicatechin gallate	15-18	glucose-6-phosphate dehydrogenase	Homo sapiens	63-96
23859040-0	2013	Epicatechin gallate induces cell death via p53 activation and stimulation of p38 and JNK in human colon cancer SW480 cells.	epicatechin gallate	0-19	tumor protein p53	Homo sapiens	43-46
24018685-0	2013	Activation of the hTAS2R14 human bitter-taste receptor by (-)-epigallocatechin gallate and (-)-epicatechin gallate.	epicatechin gallate	91-114	taste 2 receptor member 14	Homo sapiens	18-26
24018685-3	2013	Although hTAS2R14 responded to (-)-epicatechin gallate and (-)-epigallocatechin gallate, it did not respond to (-)-epicatechin and (-)-epigallocatechin.	epicatechin gallate	31-54	taste 2 receptor member 14	Homo sapiens	9-17
23859040-0	2013	Epicatechin gallate induces cell death via p53 activation and stimulation of p38 and JNK in human colon cancer SW480 cells.	epicatechin gallate	0-19	mitogen-activated protein kinase 14	Homo sapiens	77-80
23859040-0	2013	Epicatechin gallate induces cell death via p53 activation and stimulation of p38 and JNK in human colon cancer SW480 cells.	epicatechin gallate	0-19	mitogen-activated protein kinase 8	Homo sapiens	85-88
23859040-2	2013	In this study, the in vitro anticancer effects of ECG on SW480 colon cancer cell line was investigated by analyzing the cell cycle, apoptosis, key proteins involved in cellular survival/proliferation, namely AKT/phosphatidylinositol-3-kinase (PI3K) and mitogen-activated protein kinases (MAPKs), and the role of p53 in these processes.	epicatechin gallate	50-53	AKT serine/threonine kinase 1	Homo sapiens	208-211
23859040-2	2013	In this study, the in vitro anticancer effects of ECG on SW480 colon cancer cell line was investigated by analyzing the cell cycle, apoptosis, key proteins involved in cellular survival/proliferation, namely AKT/phosphatidylinositol-3-kinase (PI3K) and mitogen-activated protein kinases (MAPKs), and the role of p53 in these processes.	epicatechin gallate	50-53	tumor protein p53	Homo sapiens	312-315
23859040-3	2013	ECG induced cell cycle arrest at the G0/G1-S phase border associated with the stimulation of p21, p-p53, and p53 and the suppression of cyclins D1 and B1.	epicatechin gallate	0-3	H3 histone pseudogene 16	Homo sapiens	93-96
23859040-3	2013	ECG induced cell cycle arrest at the G0/G1-S phase border associated with the stimulation of p21, p-p53, and p53 and the suppression of cyclins D1 and B1.	epicatechin gallate	0-3	tumor protein p53	Homo sapiens	100-103
23859040-3	2013	ECG induced cell cycle arrest at the G0/G1-S phase border associated with the stimulation of p21, p-p53, and p53 and the suppression of cyclins D1 and B1.	epicatechin gallate	0-3	tumor protein p53	Homo sapiens	109-112
23859040-3	2013	ECG induced cell cycle arrest at the G0/G1-S phase border associated with the stimulation of p21, p-p53, and p53 and the suppression of cyclins D1 and B1.	epicatechin gallate	0-3	cyclin D1	Homo sapiens	136-153
23859040-5	2013	The presence of pifithrin, an inhibitor of p53 function, blocked ECG-induced apoptosis as was manifested by restored cell viability and caspase-3 activity to control values and reestablished the balance among Bcl-2 anti- and proapoptotic protein levels.	epicatechin gallate	65-68	tumor protein p53	Homo sapiens	43-46
23859040-5	2013	The presence of pifithrin, an inhibitor of p53 function, blocked ECG-induced apoptosis as was manifested by restored cell viability and caspase-3 activity to control values and reestablished the balance among Bcl-2 anti- and proapoptotic protein levels.	epicatechin gallate	65-68	caspase 3	Homo sapiens	136-145
23859040-5	2013	The presence of pifithrin, an inhibitor of p53 function, blocked ECG-induced apoptosis as was manifested by restored cell viability and caspase-3 activity to control values and reestablished the balance among Bcl-2 anti- and proapoptotic protein levels.	epicatechin gallate	65-68	BCL2 apoptosis regulator	Homo sapiens	209-214
23859040-8	2013	The results suggest that the activation of the p53-p38/JNK cascade is required for ECG-induced cell death in SW480 cells.	epicatechin gallate	83-86	tumor protein p53	Homo sapiens	47-50
23859040-8	2013	The results suggest that the activation of the p53-p38/JNK cascade is required for ECG-induced cell death in SW480 cells.	epicatechin gallate	83-86	mitogen-activated protein kinase 14	Homo sapiens	51-54
23859040-8	2013	The results suggest that the activation of the p53-p38/JNK cascade is required for ECG-induced cell death in SW480 cells.	epicatechin gallate	83-86	mitogen-activated protein kinase 8	Homo sapiens	55-58
21813650-3	2011	We have previously shown that two of the polyphenols from green tea (epigallocatechin gallate (EGCG) and epicatechin gallate (ECG)) inhibit GDH in vitro and that EGCG blocks GDH-mediated insulin secretion in wild type rat islets.	epicatechin gallate	105-124	glutamate dehydrogenase 1	Homo sapiens	140-143
22342466-9	2012	These results demonstrate that MF, EGCG and ECG are potentially able to enhance targeting combination of insulin with L02 cells and improve insulin sensitivity in L02 cells.	epicatechin gallate	44-47	insulin	Homo sapiens	105-112
22342466-9	2012	These results demonstrate that MF, EGCG and ECG are potentially able to enhance targeting combination of insulin with L02 cells and improve insulin sensitivity in L02 cells.	epicatechin gallate	44-47	insulin	Homo sapiens	140-147
22191431-5	2012	Moreover, we found that after 5 h of palmitate incubation, epicatechin gallate (ECG) can suppress IRS-1 Ser307 phosphorylation and significantly promote Akt, ERK1/2, p38 MAPK, and AMP-activated protein kinase activation.	epicatechin gallate	59-78	insulin receptor substrate 1	Mus musculus	98-103
22191431-5	2012	Moreover, we found that after 5 h of palmitate incubation, epicatechin gallate (ECG) can suppress IRS-1 Ser307 phosphorylation and significantly promote Akt, ERK1/2, p38 MAPK, and AMP-activated protein kinase activation.	epicatechin gallate	59-78	thymoma viral proto-oncogene 1	Mus musculus	153-156
22191431-5	2012	Moreover, we found that after 5 h of palmitate incubation, epicatechin gallate (ECG) can suppress IRS-1 Ser307 phosphorylation and significantly promote Akt, ERK1/2, p38 MAPK, and AMP-activated protein kinase activation.	epicatechin gallate	59-78	mitogen-activated protein kinase 3	Mus musculus	158-164
22191431-5	2012	Moreover, we found that after 5 h of palmitate incubation, epicatechin gallate (ECG) can suppress IRS-1 Ser307 phosphorylation and significantly promote Akt, ERK1/2, p38 MAPK, and AMP-activated protein kinase activation.	epicatechin gallate	59-78	mitogen-activated protein kinase 14	Mus musculus	166-174
22191431-5	2012	Moreover, we found that after 5 h of palmitate incubation, epicatechin gallate (ECG) can suppress IRS-1 Ser307 phosphorylation and significantly promote Akt, ERK1/2, p38 MAPK, and AMP-activated protein kinase activation.	epicatechin gallate	80-83	insulin receptor substrate 1	Mus musculus	98-103
22191431-5	2012	Moreover, we found that after 5 h of palmitate incubation, epicatechin gallate (ECG) can suppress IRS-1 Ser307 phosphorylation and significantly promote Akt, ERK1/2, p38 MAPK, and AMP-activated protein kinase activation.	epicatechin gallate	80-83	thymoma viral proto-oncogene 1	Mus musculus	153-156
22191431-5	2012	Moreover, we found that after 5 h of palmitate incubation, epicatechin gallate (ECG) can suppress IRS-1 Ser307 phosphorylation and significantly promote Akt, ERK1/2, p38 MAPK, and AMP-activated protein kinase activation.	epicatechin gallate	80-83	mitogen-activated protein kinase 3	Mus musculus	158-164
22191431-5	2012	Moreover, we found that after 5 h of palmitate incubation, epicatechin gallate (ECG) can suppress IRS-1 Ser307 phosphorylation and significantly promote Akt, ERK1/2, p38 MAPK, and AMP-activated protein kinase activation.	epicatechin gallate	80-83	mitogen-activated protein kinase 14	Mus musculus	166-174
22191431-6	2012	With a longer incubation with palmitate, IRS-1 exhibited a dramatic depletion, and treatment with EGCG, ECG, and curcumin could reverse IRS-1 expression, Akt phosphorylation, and MAPK signaling cascade activation and improve glucose uptake in C2C12 skeletal muscle cells, especially ECG and curcumin.	epicatechin gallate	104-107	insulin receptor substrate 1	Mus musculus	136-141
22191431-6	2012	With a longer incubation with palmitate, IRS-1 exhibited a dramatic depletion, and treatment with EGCG, ECG, and curcumin could reverse IRS-1 expression, Akt phosphorylation, and MAPK signaling cascade activation and improve glucose uptake in C2C12 skeletal muscle cells, especially ECG and curcumin.	epicatechin gallate	104-107	thymoma viral proto-oncogene 1	Mus musculus	154-157
22191431-6	2012	With a longer incubation with palmitate, IRS-1 exhibited a dramatic depletion, and treatment with EGCG, ECG, and curcumin could reverse IRS-1 expression, Akt phosphorylation, and MAPK signaling cascade activation and improve glucose uptake in C2C12 skeletal muscle cells, especially ECG and curcumin.	epicatechin gallate	104-107	mitogen-activated protein kinase 1	Mus musculus	179-183
21813650-3	2011	We have previously shown that two of the polyphenols from green tea (epigallocatechin gallate (EGCG) and epicatechin gallate (ECG)) inhibit GDH in vitro and that EGCG blocks GDH-mediated insulin secretion in wild type rat islets.	epicatechin gallate	105-124	glutamate dehydrogenase 1	Homo sapiens	174-177
21813650-3	2011	We have previously shown that two of the polyphenols from green tea (epigallocatechin gallate (EGCG) and epicatechin gallate (ECG)) inhibit GDH in vitro and that EGCG blocks GDH-mediated insulin secretion in wild type rat islets.	epicatechin gallate	126-129	glutamate dehydrogenase 1	Homo sapiens	140-143
21813650-3	2011	We have previously shown that two of the polyphenols from green tea (epigallocatechin gallate (EGCG) and epicatechin gallate (ECG)) inhibit GDH in vitro and that EGCG blocks GDH-mediated insulin secretion in wild type rat islets.	epicatechin gallate	126-129	glutamate dehydrogenase 1	Homo sapiens	174-177
21358585-3	2011	The compounds (-)-epigallocatechin-3-O-gallate (4) and (-)-epicatechin-3-O-gallate (5) possess free radical scavenging activities and compound 1 could inhibit superoxide anion generation and elastase release by fMLP/CB-induced human neutrophils with IC50 values of 19.33 +- 0.86 and 24.14 +- 1.59 muM, respectively.	epicatechin gallate	55-82	formyl peptide receptor 1	Homo sapiens	211-215
21241417-8	2011	Importantly, catechins, in particular ECG, inhibited TNFalpha-induced activation of NF-kappaB and consequently secretion of pro-inflammatory and invasion promoting proteins like IL-8 and uPA.	epicatechin gallate	38-41	proline rich acidic protein 1	Homo sapiens	187-190
21272567-4	2011	By the cell-based assay using cultured cells expressing human bitter taste receptor, a clear response of hTAS2R39-expressing cells was observed to 300muM of either ECg or EGCg, which elicit a strong bitterness in humans.	epicatechin gallate	164-167	taste 2 receptor member 39	Homo sapiens	105-113
21272567-5	2011	The response of hTAS2R39-expressing cells to ECg was the strongest among the tested catechins, followed by EGCg.	epicatechin gallate	45-48	taste 2 receptor member 39	Homo sapiens	16-24
21278283-4	2011	Uptake by OATP1A2, OATP1B1, and OATP2B1 was inhibited by epicatechin gallate (ECG) and epigallocatechin gallate (EGCG) in a concentration-dependent way.	epicatechin gallate	57-76	solute carrier organic anion transporter family member 1A2	Homo sapiens	10-17
21278283-4	2011	Uptake by OATP1A2, OATP1B1, and OATP2B1 was inhibited by epicatechin gallate (ECG) and epigallocatechin gallate (EGCG) in a concentration-dependent way.	epicatechin gallate	57-76	solute carrier organic anion transporter family member 1B1	Homo sapiens	19-26
21278283-4	2011	Uptake by OATP1A2, OATP1B1, and OATP2B1 was inhibited by epicatechin gallate (ECG) and epigallocatechin gallate (EGCG) in a concentration-dependent way.	epicatechin gallate	57-76	solute carrier organic anion transporter family member 2B1	Homo sapiens	32-39
21278283-4	2011	Uptake by OATP1A2, OATP1B1, and OATP2B1 was inhibited by epicatechin gallate (ECG) and epigallocatechin gallate (EGCG) in a concentration-dependent way.	epicatechin gallate	78-81	solute carrier organic anion transporter family member 1A2	Homo sapiens	10-17
21278283-4	2011	Uptake by OATP1A2, OATP1B1, and OATP2B1 was inhibited by epicatechin gallate (ECG) and epigallocatechin gallate (EGCG) in a concentration-dependent way.	epicatechin gallate	78-81	solute carrier organic anion transporter family member 1B1	Homo sapiens	19-26
21278283-4	2011	Uptake by OATP1A2, OATP1B1, and OATP2B1 was inhibited by epicatechin gallate (ECG) and epigallocatechin gallate (EGCG) in a concentration-dependent way.	epicatechin gallate	78-81	solute carrier organic anion transporter family member 2B1	Homo sapiens	32-39
21278283-7	2011	Both ECG and EGCG were found to be substrates of OATP1A2 (K(m) values of 10.4 and 18.8 muM, respectively) and OATP1B3 (34.1 and 13.2 muM, respectively) but not of OATP1B1 or OATP2B1.	epicatechin gallate	5-8	solute carrier organic anion transporter family member 1A2	Homo sapiens	49-56
21278283-7	2011	Both ECG and EGCG were found to be substrates of OATP1A2 (K(m) values of 10.4 and 18.8 muM, respectively) and OATP1B3 (34.1 and 13.2 muM, respectively) but not of OATP1B1 or OATP2B1.	epicatechin gallate	5-8	latexin	Homo sapiens	87-90
21278283-7	2011	Both ECG and EGCG were found to be substrates of OATP1A2 (K(m) values of 10.4 and 18.8 muM, respectively) and OATP1B3 (34.1 and 13.2 muM, respectively) but not of OATP1B1 or OATP2B1.	epicatechin gallate	5-8	solute carrier organic anion transporter family member 1B3	Homo sapiens	110-117
21278283-7	2011	Both ECG and EGCG were found to be substrates of OATP1A2 (K(m) values of 10.4 and 18.8 muM, respectively) and OATP1B3 (34.1 and 13.2 muM, respectively) but not of OATP1B1 or OATP2B1.	epicatechin gallate	5-8	latexin	Homo sapiens	133-136
21278283-7	2011	Both ECG and EGCG were found to be substrates of OATP1A2 (K(m) values of 10.4 and 18.8 muM, respectively) and OATP1B3 (34.1 and 13.2 muM, respectively) but not of OATP1B1 or OATP2B1.	epicatechin gallate	5-8	solute carrier organic anion transporter family member 1B1	Homo sapiens	163-170
21278283-7	2011	Both ECG and EGCG were found to be substrates of OATP1A2 (K(m) values of 10.4 and 18.8 muM, respectively) and OATP1B3 (34.1 and 13.2 muM, respectively) but not of OATP1B1 or OATP2B1.	epicatechin gallate	5-8	solute carrier organic anion transporter family member 2B1	Homo sapiens	174-181
21241417-8	2011	Importantly, catechins, in particular ECG, inhibited TNFalpha-induced activation of NF-kappaB and consequently secretion of pro-inflammatory and invasion promoting proteins like IL-8 and uPA.	epicatechin gallate	38-41	tumor necrosis factor	Homo sapiens	53-61
21241417-8	2011	Importantly, catechins, in particular ECG, inhibited TNFalpha-induced activation of NF-kappaB and consequently secretion of pro-inflammatory and invasion promoting proteins like IL-8 and uPA.	epicatechin gallate	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	178-182
21857146-3	2011	Single injection of human CG (hCG) or equine CG (eCG) into immature (3 week old) rats up-regulated ovarian expression of ENO2.	epicatechin gallate	49-52	enolase 2	Rattus norvegicus	121-125
20514403-6	2010	Consistent with these results, the intracellular retention of rhodamine 123, a P-gp substrate, was increased and the level of P-gp was decreased in cells concurrently treated with DOX and ECG or EGCG.	epicatechin gallate	188-191	phosphoglycolate phosphatase	Mus musculus	79-83
19855084-0	2010	Epicatechin gallate suppresses oxidative stress-induced MUC5AC overexpression by interaction with epidermal growth factor receptor.	epicatechin gallate	0-19	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	56-62
19855084-0	2010	Epicatechin gallate suppresses oxidative stress-induced MUC5AC overexpression by interaction with epidermal growth factor receptor.	epicatechin gallate	0-19	epidermal growth factor receptor	Homo sapiens	98-130
19855084-1	2010	The goal of this study was to investigate the effect of epicatechin gallate (ECG), a component of green tea polyphenols, on the signal pathway for oxidative stress-induced intracellular reactive oxygen species (ROS) generation and MUC5AC overexpression in normal human nasal epithelial (NHNE) cells.	epicatechin gallate	56-75	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	231-237
19855084-1	2010	The goal of this study was to investigate the effect of epicatechin gallate (ECG), a component of green tea polyphenols, on the signal pathway for oxidative stress-induced intracellular reactive oxygen species (ROS) generation and MUC5AC overexpression in normal human nasal epithelial (NHNE) cells.	epicatechin gallate	77-80	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	231-237
20471964-3	2010	We report that the type 1 ryanodine receptor (RyR1) is a molecular target that responds to nanomolar (-)-epigallocatechin-3-gallate (EGCG) and (-)-epicatechin-3-gallate (ECG).	epicatechin gallate	143-168	ryanodine receptor 1	Homo sapiens	46-50
20471964-3	2010	We report that the type 1 ryanodine receptor (RyR1) is a molecular target that responds to nanomolar (-)-epigallocatechin-3-gallate (EGCG) and (-)-epicatechin-3-gallate (ECG).	epicatechin gallate	170-173	ryanodine receptor 1	Homo sapiens	46-50
20471964-6	2010	Four related catechins, EGCG, ECG, EGC ((-)-epigallocatechin) and EC ((-)-epicatechin) showed a rank order of activity toward RyR1 (EGCG>ECG>>EGC>>>EC).	epicatechin gallate	30-33	ryanodine receptor 1	Homo sapiens	126-130
20471964-7	2010	EGCG and ECG enhance the sensitivity of RyR1 to activation by < or =100microM cytoplasmic Ca(2+) without altering inhibitory potency by >100microM Ca(2+).	epicatechin gallate	9-12	ryanodine receptor 1	Homo sapiens	40-44
20471964-9	2010	The results identify RyR1 as a sensitive target for the major tea catechins EGCG and ECG, and this interaction is likely to contribute to their observed biological activities.	epicatechin gallate	85-88	ryanodine receptor 1	Homo sapiens	21-25
20516078-0	2010	Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2.	epicatechin gallate	13-32	AT695_RS11765	Staphylococcus aureus	119-145
20516078-0	2010	Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2.	epicatechin gallate	13-32	AT695_RS11765	Staphylococcus aureus	147-150
20455202-4	2010	The concentration of EGCG that decreased insulin-stimulated glucose uptake by 50-60% was approximately 5-10 microM for a period of 2 h. At 10 microM, EGCG and gallic acid were more effective than (-)-epicatechin, (-)-epigallocatechin, and (-)-epicatechin 3-gallate.	epicatechin gallate	239-264	insulin	Oryctolagus cuniculus	41-48
20514403-5	2010	Furthermore, the administration of DOX in combination with ECG or EGCG markedly enhanced intracellular DOX accumulation, which implies that the catechins inhibited P-glycoprotein (P-gp) efflux pump activity.	epicatechin gallate	59-62	phosphoglycolate phosphatase	Mus musculus	164-178
20514403-5	2010	Furthermore, the administration of DOX in combination with ECG or EGCG markedly enhanced intracellular DOX accumulation, which implies that the catechins inhibited P-glycoprotein (P-gp) efflux pump activity.	epicatechin gallate	59-62	phosphoglycolate phosphatase	Mus musculus	180-184
20514403-6	2010	Consistent with these results, the intracellular retention of rhodamine 123, a P-gp substrate, was increased and the level of P-gp was decreased in cells concurrently treated with DOX and ECG or EGCG.	epicatechin gallate	188-191	phosphoglycolate phosphatase	Mus musculus	126-130
20202836-1	2010	Exploration for inhibitors against expression of IgE receptor (Fc epsilonRI) on human mast cell, a significant trigger to acute and chronic allergic symptoms, disclosed epigallocatechin gallate (EGCG), epicatechin gallate, and gallocatechin gallate as active principles.	epicatechin gallate	202-221	Fc epsilon receptor Ia	Homo sapiens	63-75
19616927-3	2010	In this study, we investigated the mechanisms by which EGCG and ECG inhibit oncostatin M (OSM)-induced CXCL10 production in HGFs.	epicatechin gallate	64-67	oncostatin M	Homo sapiens	76-88
19616927-3	2010	In this study, we investigated the mechanisms by which EGCG and ECG inhibit oncostatin M (OSM)-induced CXCL10 production in HGFs.	epicatechin gallate	64-67	C-X-C motif chemokine ligand 10	Homo sapiens	103-109
19616927-6	2010	EGCG and ECG prevented OSM-mediated CXCL10 production by HGFs.	epicatechin gallate	9-12	C-X-C motif chemokine ligand 10	Homo sapiens	36-42
19616927-9	2010	ECG prevented phosphorylation of JNK and Akt (Ser473).	epicatechin gallate	0-3	mitogen-activated protein kinase 8	Homo sapiens	33-36
19616927-9	2010	ECG prevented phosphorylation of JNK and Akt (Ser473).	epicatechin gallate	0-3	AKT serine/threonine kinase 1	Homo sapiens	41-44
19616927-10	2010	In addition, EGCG and ECG attenuated OSMR beta expression on HGFs.	epicatechin gallate	22-25	oncostatin M receptor	Homo sapiens	37-46
20461739-3	2010	In this study, we investigated the mechanisms by which EGCG, ECG, and TFDG inhibit tumor necrosis factor superfamily 14 (TNFSF14)-induced IL-6 production in HGFs.	epicatechin gallate	61-64	TNF superfamily member 14	Homo sapiens	83-119
20461739-3	2010	In this study, we investigated the mechanisms by which EGCG, ECG, and TFDG inhibit tumor necrosis factor superfamily 14 (TNFSF14)-induced IL-6 production in HGFs.	epicatechin gallate	61-64	TNF superfamily member 14	Homo sapiens	121-128
20461739-3	2010	In this study, we investigated the mechanisms by which EGCG, ECG, and TFDG inhibit tumor necrosis factor superfamily 14 (TNFSF14)-induced IL-6 production in HGFs.	epicatechin gallate	61-64	interleukin 6	Homo sapiens	138-142
20461739-6	2010	EGCG, ECG, and TFDG prevented TNFSF14-mediated IL-6 production in HGFs.	epicatechin gallate	6-9	TNF superfamily member 14	Homo sapiens	30-37
20461739-6	2010	EGCG, ECG, and TFDG prevented TNFSF14-mediated IL-6 production in HGFs.	epicatechin gallate	6-9	interleukin 6	Homo sapiens	47-51
20461739-7	2010	EGCG, ECG, and TFDG prevented TNFSF14-induced extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and nuclear factor-kappaB activation in HGFs.	epicatechin gallate	6-9	TNF superfamily member 14	Homo sapiens	30-37
20461739-7	2010	EGCG, ECG, and TFDG prevented TNFSF14-induced extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and nuclear factor-kappaB activation in HGFs.	epicatechin gallate	6-9	mitogen-activated protein kinase 1	Homo sapiens	46-83
20461739-7	2010	EGCG, ECG, and TFDG prevented TNFSF14-induced extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and nuclear factor-kappaB activation in HGFs.	epicatechin gallate	6-9	mitogen-activated protein kinase 1	Homo sapiens	85-88
20461739-7	2010	EGCG, ECG, and TFDG prevented TNFSF14-induced extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and nuclear factor-kappaB activation in HGFs.	epicatechin gallate	6-9	mitogen-activated protein kinase 8	Homo sapiens	91-114
20461739-7	2010	EGCG, ECG, and TFDG prevented TNFSF14-induced extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and nuclear factor-kappaB activation in HGFs.	epicatechin gallate	6-9	mitogen-activated protein kinase 8	Homo sapiens	116-119
20461739-9	2010	In addition, EGCG, ECG, and TFDG attenuated TNFSF14 receptor expression on HGFs.	epicatechin gallate	19-22	TNF superfamily member 14	Homo sapiens	44-51
20176036-9	2010	In this study, we demonstrated that the up-regulated expressions of IL-8 or PGE(2) in Streptococci or PAMP-stimulated HDPF were inhibited by catechins, (-)-epicatechin gallate (ECG) and (-)-epigallocatechin gallate (EGCG).	epicatechin gallate	152-175	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
20176036-9	2010	In this study, we demonstrated that the up-regulated expressions of IL-8 or PGE(2) in Streptococci or PAMP-stimulated HDPF were inhibited by catechins, (-)-epicatechin gallate (ECG) and (-)-epigallocatechin gallate (EGCG).	epicatechin gallate	152-175	adrenomedullin	Homo sapiens	102-106
20176036-9	2010	In this study, we demonstrated that the up-regulated expressions of IL-8 or PGE(2) in Streptococci or PAMP-stimulated HDPF were inhibited by catechins, (-)-epicatechin gallate (ECG) and (-)-epigallocatechin gallate (EGCG).	epicatechin gallate	177-180	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
20176036-9	2010	In this study, we demonstrated that the up-regulated expressions of IL-8 or PGE(2) in Streptococci or PAMP-stimulated HDPF were inhibited by catechins, (-)-epicatechin gallate (ECG) and (-)-epigallocatechin gallate (EGCG).	epicatechin gallate	177-180	adrenomedullin	Homo sapiens	102-106
19722703-8	2009	Concentration-dependent correlations between enhanced NO level and endothelial nitric oxide synthase (eNOS) expression were demonstrated for the three polyphenols tested (resveratrol, ECg, and EGCg).	epicatechin gallate	184-187	nitric oxide synthase 3	Homo sapiens	67-100
20054477-3	2009	To avoid stability and bioavailability problems associated with tea catechins we synthesized a methylated derivative of ECG (3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin; TMECG), which effectively binds to DHFR (K(D) = 2.1 microM).	epicatechin gallate	120-123	dihydrofolate reductase	Homo sapiens	207-211
20487003-6	2010	The presence of EGCG and ECG significantly reduced, in a concentration-dependent manner, the expression of IL-6 and IL-8 in dental pulp cells exposed to LPS or PG.	epicatechin gallate	25-28	interleukin 6	Homo sapiens	107-111
20487003-6	2010	The presence of EGCG and ECG significantly reduced, in a concentration-dependent manner, the expression of IL-6 and IL-8 in dental pulp cells exposed to LPS or PG.	epicatechin gallate	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
20487003-7	2010	Increased expression of ICAM-1 and VCAM-1 on the dental pulp cells in response to bacterial components was also decreased by treatment with EGCG and ECG.	epicatechin gallate	149-152	intercellular adhesion molecule 1	Homo sapiens	24-30
20487003-7	2010	Increased expression of ICAM-1 and VCAM-1 on the dental pulp cells in response to bacterial components was also decreased by treatment with EGCG and ECG.	epicatechin gallate	149-152	vascular cell adhesion molecule 1	Homo sapiens	35-41
19157820-2	2010	Our microarray data showed that the green tea component epicatechin-3-gallate suppressed NUDT6 expression, and this was confirmed by RT-PCR.	epicatechin gallate	56-77	nudix hydrolase 6	Homo sapiens	89-94
18266932-7	2008	Moreover, (-)-epicatechin gallate, a ROS scavenger, elevated HIF-1alpha expression in the neurons subjected to in vitro ischemia.	epicatechin gallate	10-33	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	61-71
18533286-5	2008	ECG or EGCG significantly increased CYP7A1 promoter activity by 6.0- or 4.0-fold, respectively, compared with the control.	epicatechin gallate	0-3	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	36-42
19531491-4	2009	Subsequent studies demonstrated that wild-type and hyperinsulinemia/hyperammonemia forms of GDH are inhibited by the green tea polyphenols, epigallocatechin gallate and epicatechin gallate.	epicatechin gallate	169-188	glutamate dehydrogenase 1	Homo sapiens	92-95
19722586-5	2009	Theaflavin-3,3"-digallate (TFDG) was more effective in inhibiting the activity of pancreatic lipase than epigallocatechin gallate (EGCG), epicatechin gallate (ECG), and a mixture of EGCG and ECG.	epicatechin gallate	191-194	pancreatic lipase	Rattus norvegicus	82-99
19176763-7	2009	Generally, EGCG was more effective than epicatechin, epicatechin gallate, and epigallocatechin in modulating insulin-stimulated mitogenic signaling.	epicatechin gallate	53-72	insulin	Homo sapiens	109-116
19262011-5	2009	Interestingly, EC, ECg, EGCg and quercetin significantly decreased the expression of atrogin-1 and MuRF-1 up-regulated by 3D-clinorotation, whereas they hardly affected atrogene expression induced by dexamethasone.	epicatechin gallate	19-22	F-box protein 32	Mus musculus	85-94
19262011-5	2009	Interestingly, EC, ECg, EGCg and quercetin significantly decreased the expression of atrogin-1 and MuRF-1 up-regulated by 3D-clinorotation, whereas they hardly affected atrogene expression induced by dexamethasone.	epicatechin gallate	19-22	tripartite motif-containing 63	Mus musculus	99-105
19262011-8	2009	As expected, EC, ECg, EGCg, and quercetin significantly suppressed phosphorylation of ERK, corresponding to the up-regulation of atrogenes induced by 3D-clinorotation.	epicatechin gallate	17-20	mitogen-activated protein kinase 1	Mus musculus	86-89
19910679-3	2009	In this study, we investigated the mechanisms by which EGCG and ECG inhibit interleukin (IL)-17A-induced CCL20 production in human gingival fibroblasts.	epicatechin gallate	64-67	C-C motif chemokine ligand 20	Homo sapiens	105-110
19910679-5	2009	EGCG and ECG prevented IL-17A-mediated CCL20 production in HGFs.	epicatechin gallate	9-12	interleukin 17A	Homo sapiens	23-29
19910679-5	2009	EGCG and ECG prevented IL-17A-mediated CCL20 production in HGFs.	epicatechin gallate	9-12	C-C motif chemokine ligand 20	Homo sapiens	39-44
19910679-7	2009	EGCG and ECG prevented IL-17A-induced phosphorylation of p38 MAPK and ERK in HGFs.	epicatechin gallate	9-12	interleukin 17A	Homo sapiens	23-29
19910679-7	2009	EGCG and ECG prevented IL-17A-induced phosphorylation of p38 MAPK and ERK in HGFs.	epicatechin gallate	9-12	mitogen-activated protein kinase 1	Homo sapiens	70-73
18718123-6	2008	BCRP was not an efflux transporter for ECG, and the influences of MRP2 and P-gp on ECG efflux were lower than for EC.	epicatechin gallate	83-86	ATP binding cassette subfamily C member 2	Homo sapiens	66-70
18718123-6	2008	BCRP was not an efflux transporter for ECG, and the influences of MRP2 and P-gp on ECG efflux were lower than for EC.	epicatechin gallate	83-86	ATP binding cassette subfamily B member 1	Homo sapiens	75-79
18066651-0	2008	Epicatechin gallate increases glutamate uptake and S100B secretion in C6 cell lineage.	epicatechin gallate	0-19	S100 calcium binding protein B	Homo sapiens	51-56
18066651-8	2008	In addition, a significant increase in S100B was observed at 1 microM ECG (36%) and 10 microM ECG (69%) after 1 h, in contrast to 6 h of treatment, where all doses of ECG induced a significant increase (about 60%) in S100B secretion.	epicatechin gallate	70-73	S100 calcium binding protein B	Homo sapiens	39-44
18066651-8	2008	In addition, a significant increase in S100B was observed at 1 microM ECG (36%) and 10 microM ECG (69%) after 1 h, in contrast to 6 h of treatment, where all doses of ECG induced a significant increase (about 60%) in S100B secretion.	epicatechin gallate	94-97	S100 calcium binding protein B	Homo sapiens	39-44
18066651-8	2008	In addition, a significant increase in S100B was observed at 1 microM ECG (36%) and 10 microM ECG (69%) after 1 h, in contrast to 6 h of treatment, where all doses of ECG induced a significant increase (about 60%) in S100B secretion.	epicatechin gallate	94-97	S100 calcium binding protein B	Homo sapiens	39-44
18066651-9	2008	These data demonstrate that ECG induces a significant improvement in glutamate uptake and S100B secretion in C6 cells, indicating that ECG could contribute to the neuroprotective role of astroglial cells.	epicatechin gallate	28-31	S100 calcium binding protein B	Homo sapiens	90-95
17436062-9	2007	Taken together, the data presented here provide evidence showing that among these tea catechins, EGCG and ECG are relatively effective inhibitors on SMC-ECM interaction and their action mechanisms are through interference with SMC"s integrin beta1 receptor and binding to ECM proteins.	epicatechin gallate	106-109	integrin subunit beta 1	Rattus norvegicus	233-247
17876860-7	2007	The tea constituents, (-)-epicatechin gallate and (-)-epigallocatechin gallate, both almost completely inhibited SULT1A1 and SULT1A3.	epicatechin gallate	22-45	sulfotransferase family 1A member 1	Homo sapiens	113-120
17876860-7	2007	The tea constituents, (-)-epicatechin gallate and (-)-epigallocatechin gallate, both almost completely inhibited SULT1A1 and SULT1A3.	epicatechin gallate	22-45	sulfotransferase family 1A member 3	Homo sapiens	125-132
17764926-0	2007	Green tea catechin (-)-epicatechin gallate induces tumour suppressor protein ATF3 via EGR-1 activation.	epicatechin gallate	19-42	activating transcription factor 3	Homo sapiens	77-81
17764926-0	2007	Green tea catechin (-)-epicatechin gallate induces tumour suppressor protein ATF3 via EGR-1 activation.	epicatechin gallate	19-42	early growth response 1	Homo sapiens	86-91
17764926-3	2007	In this report, we present a molecular mechanism by which ECG induces ATF3 expression at the transcriptional level.	epicatechin gallate	58-61	activating transcription factor 3	Homo sapiens	70-74
17764926-6	2007	We also found that pro-oxidant activity of ECG contributed to ECG-induced ATF3 expression.	epicatechin gallate	43-46	activating transcription factor 3	Homo sapiens	74-78
17504202-0	2007	Epigallocatechin-3-gallate and epicatechin-3-gallate from green tea decrease plasma non-transferrin bound iron and erythrocyte oxidative stress.	epicatechin gallate	31-52	transferrin	Homo sapiens	88-99
17227057-4	2007	Epicatechin gallate (ECG) was found to be a potent inhibitor as it inhibited HDC activity in a competitive manner with Ki = 10 muM against l-histidine.	epicatechin gallate	0-19	histidine decarboxylase	Homo sapiens	77-80
17227057-4	2007	Epicatechin gallate (ECG) was found to be a potent inhibitor as it inhibited HDC activity in a competitive manner with Ki = 10 muM against l-histidine.	epicatechin gallate	21-24	histidine decarboxylase	Homo sapiens	77-80
17045795-0	2006	Growth inhibition and apoptosis by (-)-epicatechin gallate are mediated by cyclin D1 suppression in head and neck squamous carcinoma cells.	epicatechin gallate	35-58	cyclin D1	Mus musculus	75-84
16449979-0	2006	The green tea catechins, (-)-Epigallocatechin-3-gallate (EGCG) and (-)-Epicatechin-3-gallate (ECG), inhibit HGF/Met signaling in immortalized and tumorigenic breast epithelial cells.	epicatechin gallate	67-92	hepatocyte growth factor	Homo sapiens	108-111
17079869-4	2006	Here we report that catechin, epicatechin (EC), epicatechingallate (ECG) or epigallocatechingallate (EGCG) significantly inhibits the Ang II-induced [3H]thymidine incorporation into the primary cultured rat aortic VSMC.	epicatechin gallate	48-66	angiotensinogen	Rattus norvegicus	134-140
17079869-4	2006	Here we report that catechin, epicatechin (EC), epicatechingallate (ECG) or epigallocatechingallate (EGCG) significantly inhibits the Ang II-induced [3H]thymidine incorporation into the primary cultured rat aortic VSMC.	epicatechin gallate	68-71	angiotensinogen	Rattus norvegicus	134-140
16884715-0	2006	Copper complexes of (-)-epicatechin gallate and (-)-epigallocatechin gallate act as inhibitors of Ribonuclease A.	epicatechin gallate	20-43	ribonuclease A family member 1, pancreatic	Homo sapiens	98-112
16884715-2	2006	Copper complexes of (-)-epicatechin gallate and (-)-epigallocatechin gallate were found to inhibit the enzymatic activity of Ribonuclease A (RNase A) as revealed by an agarose gel based assay and urea denatured gel electrophoresis.	epicatechin gallate	20-43	ribonuclease A family member 1, pancreatic	Homo sapiens	125-139
16884715-2	2006	Copper complexes of (-)-epicatechin gallate and (-)-epigallocatechin gallate were found to inhibit the enzymatic activity of Ribonuclease A (RNase A) as revealed by an agarose gel based assay and urea denatured gel electrophoresis.	epicatechin gallate	20-43	ribonuclease A family member 1, pancreatic	Homo sapiens	141-148
16603228-5	2006	Epigallocatechin galate (EGCg, 1.76-fold), epicatechin galate (ECg, 1.85-fold) and myricetin (3.19-fold) stimulated SIRT1 under stabilizing conditions, whereas without stabilization, these polyphenols strongly inhibited SIRT1, probably due to H2O2 formation.	epicatechin gallate	63-66	sirtuin 1	Homo sapiens	116-121
16476731-5	2006	Of the four compounds tested, epigallocatechin gallate (EGCG) and epicatechin gallate were found to inhibit GDH with nanomolar ED(50) values and were therefore found to be as potent as the physiologically important inhibitor GTP.	epicatechin gallate	66-85	glutamate dehydrogenase 1	Homo sapiens	108-111
16449979-0	2006	The green tea catechins, (-)-Epigallocatechin-3-gallate (EGCG) and (-)-Epicatechin-3-gallate (ECG), inhibit HGF/Met signaling in immortalized and tumorigenic breast epithelial cells.	epicatechin gallate	94-97	hepatocyte growth factor	Homo sapiens	108-111
16449979-8	2006	(-)-Epicatechin-3-gallate (ECG) functioned similar to EGCG by completely blocking HGF-induced signaling as low as 0.6 microM and motility at 5 microM in MCF10A cells; whereas, (-)-epicatechin (EC) was unable to inhibit HGF-induced events at any concentration tested.	epicatechin gallate	0-25	hepatocyte growth factor	Homo sapiens	82-85
16449979-8	2006	(-)-Epicatechin-3-gallate (ECG) functioned similar to EGCG by completely blocking HGF-induced signaling as low as 0.6 microM and motility at 5 microM in MCF10A cells; whereas, (-)-epicatechin (EC) was unable to inhibit HGF-induced events at any concentration tested.	epicatechin gallate	0-25	hepatocyte growth factor	Homo sapiens	219-222
16449979-8	2006	(-)-Epicatechin-3-gallate (ECG) functioned similar to EGCG by completely blocking HGF-induced signaling as low as 0.6 microM and motility at 5 microM in MCF10A cells; whereas, (-)-epicatechin (EC) was unable to inhibit HGF-induced events at any concentration tested.	epicatechin gallate	27-30	hepatocyte growth factor	Homo sapiens	82-85
16449979-8	2006	(-)-Epicatechin-3-gallate (ECG) functioned similar to EGCG by completely blocking HGF-induced signaling as low as 0.6 microM and motility at 5 microM in MCF10A cells; whereas, (-)-epicatechin (EC) was unable to inhibit HGF-induced events at any concentration tested.	epicatechin gallate	27-30	hepatocyte growth factor	Homo sapiens	219-222
15895994-2	2005	Fluorescence quenching and stopped-flow fluorimetry show that the ester bond-containing tea polyphenols (-)-epigallocatechin gallate (EGCG) and (-)-epicatechin gallate (ECG) are potent and specific inhibitors of DHFR with inhibition constants (K(I)) of 120 and 82 nM, respectively.	epicatechin gallate	144-167	dihydrofolate reductase	Bos taurus	212-216
16507512-1	2006	The hypothesis tested was that specific flavonoids such as epicatechin gallate, epigallocatechin gallate, genistein, genistin, naringenin, naringin, quercetin and xanthohumol will modulate cellular uptake and permeability (P(e)) of multidrug-resistant substrates, cyclosporin A (CSA) and digoxin, across Caco-2 and MDCKII-MDR1 cell transport models.	epicatechin gallate	59-78	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	279-282
16507512-1	2006	The hypothesis tested was that specific flavonoids such as epicatechin gallate, epigallocatechin gallate, genistein, genistin, naringenin, naringin, quercetin and xanthohumol will modulate cellular uptake and permeability (P(e)) of multidrug-resistant substrates, cyclosporin A (CSA) and digoxin, across Caco-2 and MDCKII-MDR1 cell transport models.	epicatechin gallate	59-78	ATP binding cassette subfamily B member 1	Homo sapiens	322-326
15885676-5	2005	The thrombin-induced activation of secreted MMP-2 was abolished by GTE and the green tea polyphenols (-)-epigallocatechin-3-gallate (EGCG) and (-)-epicatechin-3-gallate (ECG).	epicatechin gallate	143-168	coagulation factor II, thrombin	Homo sapiens	4-12
15885676-5	2005	The thrombin-induced activation of secreted MMP-2 was abolished by GTE and the green tea polyphenols (-)-epigallocatechin-3-gallate (EGCG) and (-)-epicatechin-3-gallate (ECG).	epicatechin gallate	143-168	matrix metallopeptidase 2	Homo sapiens	44-49
15885676-5	2005	The thrombin-induced activation of secreted MMP-2 was abolished by GTE and the green tea polyphenols (-)-epigallocatechin-3-gallate (EGCG) and (-)-epicatechin-3-gallate (ECG).	epicatechin gallate	170-173	coagulation factor II, thrombin	Homo sapiens	4-12
15885676-5	2005	The thrombin-induced activation of secreted MMP-2 was abolished by GTE and the green tea polyphenols (-)-epigallocatechin-3-gallate (EGCG) and (-)-epicatechin-3-gallate (ECG).	epicatechin gallate	170-173	matrix metallopeptidase 2	Homo sapiens	44-49
15885676-7	2005	GTE, EGCG and ECG directly inhibited cell-associated MT1-MMP activity, the physiological activator of MMP-2, in a reversible manner.	epicatechin gallate	14-17	matrix metallopeptidase 14	Homo sapiens	53-60
15885676-7	2005	GTE, EGCG and ECG directly inhibited cell-associated MT1-MMP activity, the physiological activator of MMP-2, in a reversible manner.	epicatechin gallate	14-17	matrix metallopeptidase 2	Homo sapiens	102-107
15885676-8	2005	Thrombin-stimulated VSMCs invasion was abolished by EGCG and ECG, and reduced by GTE.	epicatechin gallate	61-64	coagulation factor II, thrombin	Homo sapiens	0-8
16461931-6	2006	eCG-treated follicles showed high VEGF levels and two concentric blood vessel networks composed of proliferating endothelial cells without any association with mural components.	epicatechin gallate	0-3	vascular endothelial growth factor A	Sus scrofa	34-38
16611078-4	2006	Epigallocatechin gallate (EGCG) and epicatechin gallate (ECG) inhibit FAS with IC(50) values of 52 microM and 42 microM mainly by reacting on the beta-ketoacyl reductase (KR) domain of FAS.	epicatechin gallate	36-55	fatty acid synthase	Homo sapiens	70-73
16611078-4	2006	Epigallocatechin gallate (EGCG) and epicatechin gallate (ECG) inhibit FAS with IC(50) values of 52 microM and 42 microM mainly by reacting on the beta-ketoacyl reductase (KR) domain of FAS.	epicatechin gallate	36-55	fatty acid synthase	Homo sapiens	185-188
16611078-4	2006	Epigallocatechin gallate (EGCG) and epicatechin gallate (ECG) inhibit FAS with IC(50) values of 52 microM and 42 microM mainly by reacting on the beta-ketoacyl reductase (KR) domain of FAS.	epicatechin gallate	57-60	fatty acid synthase	Homo sapiens	70-73
16611078-4	2006	Epigallocatechin gallate (EGCG) and epicatechin gallate (ECG) inhibit FAS with IC(50) values of 52 microM and 42 microM mainly by reacting on the beta-ketoacyl reductase (KR) domain of FAS.	epicatechin gallate	57-60	fatty acid synthase	Homo sapiens	185-188
15860507-9	2005	Further, (-)-epicatechin-3-gallate (25 and 100 microM) and green tea polyphenols (33 and 132 microg/ml) induced pro-MMP-7 expression, whereas (-)-epicatechin and (-)-epigallocatechin (100 microM each) did not.	epicatechin gallate	9-34	matrix metallopeptidase 7	Homo sapiens	116-121
15895994-2	2005	Fluorescence quenching and stopped-flow fluorimetry show that the ester bond-containing tea polyphenols (-)-epigallocatechin gallate (EGCG) and (-)-epicatechin gallate (ECG) are potent and specific inhibitors of DHFR with inhibition constants (K(I)) of 120 and 82 nM, respectively.	epicatechin gallate	169-172	dihydrofolate reductase	Bos taurus	212-216
15895994-9	2005	Although DHFR exhibits different affinities for the protonated and deprotonated forms of EGCG and ECG, it appears that the ionization state of Glu-30 in DHFR is critical for its inhibition.	epicatechin gallate	98-101	dihydrofolate reductase	Bos taurus	9-13
15308587-0	2004	Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells.	epicatechin gallate	0-19	growth differentiation factor 15	Homo sapiens	42-47
15649637-4	2005	For the HGF-2 fibroblasts, ECG and CG grouped as highly toxic, EGCG as moderately toxic, and EGC, C, and EC as least toxic.	epicatechin gallate	27-30	GINGF2	Homo sapiens	8-13
15208607-3	2004	For this purpose, we studied the effect of 2 kinds of catechin, epigallocatechin gallate (EGCG) and epicatechin gallate, on peripheral blood CD8+ T cells, which play the key role in immune responses.	epicatechin gallate	100-119	CD8a molecule	Homo sapiens	141-144
15620252-0	2004	Hypoxia-inducible factor-1 activation by (-)-epicatechin gallate: potential adverse effects of cancer chemoprevention with high-dose green tea extracts.	epicatechin gallate	41-64	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-26
15620252-4	2004	We found that (-)-epicatechin-3-gallate (ECG, 1), one of the major green tea catechins, strongly activates HIF-1 in T47D human breast carcinoma cells.	epicatechin gallate	14-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-112
15620252-4	2004	We found that (-)-epicatechin-3-gallate (ECG, 1), one of the major green tea catechins, strongly activates HIF-1 in T47D human breast carcinoma cells.	epicatechin gallate	41-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-112
15257617-4	2004	Both (-)-epicatechin and (-)-epicatechin gallate (ECG) supplementation resulted in an increased GSH/GSSG ratio and glutathione reductase activities.	epicatechin gallate	25-48	glutathione-disulfide reductase	Rattus norvegicus	115-136
15257617-4	2004	Both (-)-epicatechin and (-)-epicatechin gallate (ECG) supplementation resulted in an increased GSH/GSSG ratio and glutathione reductase activities.	epicatechin gallate	50-53	glutathione-disulfide reductase	Rattus norvegicus	115-136
15630184-2	2004	We previously found that the major green tea catechin, (-)-epigallocatechin-3-O-gallate (EGCG), has the suppressive effect of the FcepsilonRI expression in the human basophilic KU812 cells, whereas (-)-epicatechin-3-O-gallate (ECG) has not.	epicatechin gallate	198-225	Fc epsilon receptor Ia	Homo sapiens	130-141
15033450-4	2004	EGCG and to a lesser extent ECG prevented the induction of VCAM-1 expression in a concentration-dependent manner after stimulation with TNF-alpha, whereas EC and EGC were without effect.	epicatechin gallate	28-31	vascular cell adhesion molecule 1	Homo sapiens	59-65
15033450-4	2004	EGCG and to a lesser extent ECG prevented the induction of VCAM-1 expression in a concentration-dependent manner after stimulation with TNF-alpha, whereas EC and EGC were without effect.	epicatechin gallate	28-31	tumor necrosis factor	Homo sapiens	136-145
15630184-2	2004	We previously found that the major green tea catechin, (-)-epigallocatechin-3-O-gallate (EGCG), has the suppressive effect of the FcepsilonRI expression in the human basophilic KU812 cells, whereas (-)-epicatechin-3-O-gallate (ECG) has not.	epicatechin gallate	227-230	Fc epsilon receptor Ia	Homo sapiens	130-141
14599562-6	2003	Another gallated catechin, (-)-epicatechin gallate, was also found as a potent inhibitor of FAS and its inhibition characteristics are similar to (-)-epigallocatechin gallate.	epicatechin gallate	27-50	fatty acid synthase	Homo sapiens	92-95
12970085-10	2003	The high affinities of ECG and EGCG for GLUT1 indicate that this might be their physiological site of action.	epicatechin gallate	23-26	solute carrier family 2 member 1	Homo sapiens	40-45
12970388-7	2003	Phloretin and benzoic acid, inhibitors of the monocarboxylate transporter (MCT), significantly reduced ECG uptake.	epicatechin gallate	103-106	solute carrier family 16 member 1	Homo sapiens	46-73
12970388-7	2003	Phloretin and benzoic acid, inhibitors of the monocarboxylate transporter (MCT), significantly reduced ECG uptake.	epicatechin gallate	103-106	solute carrier family 16 member 1	Homo sapiens	75-78
12970388-8	2003	The uptake of ECG in the Caco-2 cells increased 2-fold in the presence of 50 microM 3-[(3-[2-(7-chloroquinolin-2-yl)vinyl]phenyl)-(2-dimethylcarbamoylethylsulfanyl)methylsulfanyl] propionic acid (MK-571), suggesting the involvement of multidrug-associated protein (MRP)2 in efflux of ECG.	epicatechin gallate	14-17	ATP binding cassette subfamily C member 2	Homo sapiens	235-270
12606484-1	2003	The aim of the present study was to examine the acute and chronic effects of the gonadotropin-releasing hormone agonist (GnRH-a) leuprolide acetate (LA) on the expression of the steroidogenic acute regulatory protein (StAR), the cytochrome P450 side-chain cleavage enzyme (P450scc), and steroid production in antral ovarian follicles obtained from prepubertal equine choriogonadotropin (eCG)-treated rats.	epicatechin gallate	387-390	steroidogenic acute regulatory protein	Equus caballus	218-222
14696951-7	2003	ECG can thus offer an objective alternative for assessment of LVH in HBP in males where ECHO is not available or practicable.	epicatechin gallate	0-3	high density lipoprotein binding protein	Homo sapiens	69-72
10950844-2	2000	(-)-Epicatechin, (+)-epicatechin, and (-)-epigallocatechin were good substrates for metabolic O-methylation by placental cytosolic COMT (150-500 pmol/mg of protein/min), but (-)-epicatechin gallate and (-)-epigallocatechin gallate were O-methylated at much lower rates (<50 pmol/mg of protein/min).	epicatechin gallate	174-197	catechol-O-methyltransferase	Homo sapiens	131-135
12482547-9	2003	The antagonistic effects of other catechins, namely (-)-epigallocatechin (EGC) and (-)-epicatechin gallate (ECG), on gelatinolytic activity of MMP-2, ConA-induced pro-MMP-2 activation, or PDGF-BB-directed SMC invasion were much less pronounced than those of EGCG.	epicatechin gallate	83-106	matrix metallopeptidase 2	Bos taurus	143-148
12482547-9	2003	The antagonistic effects of other catechins, namely (-)-epigallocatechin (EGC) and (-)-epicatechin gallate (ECG), on gelatinolytic activity of MMP-2, ConA-induced pro-MMP-2 activation, or PDGF-BB-directed SMC invasion were much less pronounced than those of EGCG.	epicatechin gallate	83-106	matrix metallopeptidase 2	Bos taurus	167-172
12482547-9	2003	The antagonistic effects of other catechins, namely (-)-epigallocatechin (EGC) and (-)-epicatechin gallate (ECG), on gelatinolytic activity of MMP-2, ConA-induced pro-MMP-2 activation, or PDGF-BB-directed SMC invasion were much less pronounced than those of EGCG.	epicatechin gallate	108-111	matrix metallopeptidase 2	Bos taurus	143-148
12012004-3	2002	EGCG or ECG and genistein as a control dose-dependently inhibited the growth of A549 cells, which strongly elevated hnRNP B1 protein, and increased G2/M phase cells associated with induction of apoptotic cells.	epicatechin gallate	8-11	heterogeneous nuclear ribonucleoprotein A2/B1	Homo sapiens	116-124
12012004-6	2002	Treatment of A549 cells with EGCG, ECG or genistein significantly inhibited the expression levels of hnRNP B1 mRNA and the elevated levels of hnRNP B1 protein, both of which are constitutively elevated in cancer cells.	epicatechin gallate	35-38	heterogeneous nuclear ribonucleoprotein A2/B1	Homo sapiens	101-109
12012004-6	2002	Treatment of A549 cells with EGCG, ECG or genistein significantly inhibited the expression levels of hnRNP B1 mRNA and the elevated levels of hnRNP B1 protein, both of which are constitutively elevated in cancer cells.	epicatechin gallate	35-38	heterogeneous nuclear ribonucleoprotein A2/B1	Homo sapiens	142-150
11259344-5	2001	We also present new data on the inhibition of SULT1A enzymes by dietary chemicals, showing that compounds to which we are exposed regularly, such as epigallocatechin gallate and epicatechin gallate are extremely potent inhibitors of phenol sulfotransferases (K(i) in the nanomolar range for SULT1A1).	epicatechin gallate	178-197	sulfotransferase family 1A member 1	Homo sapiens	291-298
11243706-5	2001	Epicatechin gallate, epigallocatechin and epigallocatechin gallate decreased the production of interleukin 1beta and enhanced the production of interleukin 10, but had no effect on the production of interleukin 6 or tumour necrosis factor-alpha.	epicatechin gallate	0-19	interleukin 1 beta	Homo sapiens	95-112
11243706-5	2001	Epicatechin gallate, epigallocatechin and epigallocatechin gallate decreased the production of interleukin 1beta and enhanced the production of interleukin 10, but had no effect on the production of interleukin 6 or tumour necrosis factor-alpha.	epicatechin gallate	0-19	interleukin 10	Homo sapiens	144-158
12797478-3	2003	Moreover, oral administration of ECg significantly enhanced the activities of the antioxidant enzymes, superoxide dismutase, catalase and glutathione peroxidase, and the antioxidant glutathione, showing enhancement of the biological defense system against the damage induced by ONOO-.	epicatechin gallate	33-36	catalase	Rattus norvegicus	125-133
11809684-3	2002	Physiological concentrations (0.01-1 microM) of epigallocatechin-3 gallate, catechin-3 gallate, and, to a lesser extent, epicatechin-3 gallate induce a rapid and potent inhibition of VEGF-dependent tyrosine phosphorylation of VEGFR-2.	epicatechin gallate	121-142	vascular endothelial growth factor A	Homo sapiens	183-187
11809684-3	2002	Physiological concentrations (0.01-1 microM) of epigallocatechin-3 gallate, catechin-3 gallate, and, to a lesser extent, epicatechin-3 gallate induce a rapid and potent inhibition of VEGF-dependent tyrosine phosphorylation of VEGFR-2.	epicatechin gallate	121-142	kinase insert domain receptor	Homo sapiens	226-233
11312808-5	2000	Addition of 17beta-estradiol (E2) plus epicatechin gallate (ECG) or epigallocatechin gallate (EGCG) at 5 x 10(-6) M resulted in significant decreases in the ERalpha-mediated luc activity compared with that of E2 alone.	epicatechin gallate	39-58	estrogen receptor 1	Homo sapiens	157-164
11312808-5	2000	Addition of 17beta-estradiol (E2) plus epicatechin gallate (ECG) or epigallocatechin gallate (EGCG) at 5 x 10(-6) M resulted in significant decreases in the ERalpha-mediated luc activity compared with that of E2 alone.	epicatechin gallate	60-63	estrogen receptor 1	Homo sapiens	157-164
11312811-1	2000	(-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECg), (-)-epigallocatechin gallate (EGCg), and Trolox inhibited the decreases of apolipoprotein B-100 (apoB) and alpha-tocopherol in a radical reaction of human plasma initiated by Cu(2+).	epicatechin gallate	50-73	apolipoprotein B	Homo sapiens	156-176
11312811-1	2000	(-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECg), (-)-epigallocatechin gallate (EGCg), and Trolox inhibited the decreases of apolipoprotein B-100 (apoB) and alpha-tocopherol in a radical reaction of human plasma initiated by Cu(2+).	epicatechin gallate	50-73	apolipoprotein B	Homo sapiens	178-182
11312811-2	2000	The concentrations of EC, EGC, ECg, EGCg, and Trolox for 50% inhibition (IC50) of apoB fragmentation were 39.1, 42.2, 14.6, 21.3, and 36.2 microM, respectively.	epicatechin gallate	31-34	apolipoprotein B	Homo sapiens	82-86
9310136-4	1997	EGC and ECG inhibited the growth of PC-9 cells as potently as did EGCG, but EC did not show significant growth inhibition.	epicatechin gallate	8-11	proprotein convertase subtilisin/kexin type 9	Homo sapiens	36-40
10719174-4	2000	The activities of MMPs were also measured in the presence of various catechins isolated from green tea including (-)-epigallocatechin gallate (EGCG), (-)-epicatechin gallate(ECG), (-)-epigallocatechin (EGC), (-)-epicatechin (EC) and (+)-catechin (C).	epicatechin gallate	150-173	matrix metallopeptidase 2	Rattus norvegicus	18-22
10864803-4	2000	Immunohistochemistry and immunoblotting demonstrated the expression of E-cadherin in theca and interstitial cells of immature ovaries before and after injection of equine chorionic gonadotrophin (eCG).	epicatechin gallate	196-199	cadherin 1	Rattus norvegicus	71-81
9538336-4	1998	Both eCG and oFSH significantly increased the ovarian carbonyl reductase concentration 48 h after treatment compared with the saline-treated group, but the increase with eCG was approximately twice that with oFSH.	epicatechin gallate	5-8	dehydrogenase/reductase 4	Rattus norvegicus	54-72
9538336-9	1998	Treatment with hCG in saline-pretreated rats increased carbonyl reductase activity by 2.8-fold and carbonyl reductase concentration by 4.1-fold after 9 h compared with the 0 h concentration, without producing the large follicles observed with eCG and oFSH.	epicatechin gallate	243-246	chorionic gonadotropin subunit beta 5	Homo sapiens	15-18
10650935-6	2000	Using a whole cell RRA, we found that CNP binding was increased by 2-fold in granulosa cells taken from animals treated with either DES or eCG.	epicatechin gallate	139-142	2',3'-cyclic nucleotide 3' phosphodiesterase	Rattus norvegicus	38-41
10650935-11	2000	In contrast, CNP mRNA levels were increased more than 2-fold, but only in theca-interstitial from the eCG-treated animals.	epicatechin gallate	102-105	2',3'-cyclic nucleotide 3' phosphodiesterase	Rattus norvegicus	13-16
11237201-5	2000	ECg inhibited SGLT 1 in a competitive manner, although ECg itself was not transported via the glucose transporters.	epicatechin gallate	0-3	solute carrier family 5 member 1	Homo sapiens	14-20
10515590-4	1999	The calculated C-H bond dissociation enthalpies (BDEs) for EGCG and ECG at the C-2 position were quite low (62.7 and 66.8 kcal/mol, respectively) compared with O-H BDEs at the phenolic sites (ca.	epicatechin gallate	68-71	complement C2	Homo sapiens	79-82
10470285-4	1999	Various tea polyphenols derived from green tea and black tea induced growth inhibition and apoptosis of human stomach cancer cell line KATO III, and inhibition of tumor necrosis factor-alpha (TNF-alpha) release from the cells, in the order of (-)-epicatechin gallate (ECG), EGCG, (-)-epigallocatechin (EGC), teaflavins (TF) and (-)-epicatechin (EC).	epicatechin gallate	243-266	tumor necrosis factor	Homo sapiens	192-201
10342884-1	1999	The present studies showed that sequential treatment with equine CG (eCG) and hCG not only induced an increase in ovarian weight, but also caused an estimated 4.6-fold increase in the number of ovarian surface epithelial cells.	epicatechin gallate	69-72	hypertrichosis 2 (generalised, congenital)	Homo sapiens	65-67
10794635-5	1999	Ester-type catechins (ECg and EGCg) and theaflavin strongly suppressed the gelatin degradation mediated by matrix metalloproteinase (MMP) 2 and MMP-9, which were secreted into the conditioned medium of HT1080 cells.	epicatechin gallate	22-25	matrix metallopeptidase 2	Homo sapiens	107-139
10794635-5	1999	Ester-type catechins (ECg and EGCg) and theaflavin strongly suppressed the gelatin degradation mediated by matrix metalloproteinase (MMP) 2 and MMP-9, which were secreted into the conditioned medium of HT1080 cells.	epicatechin gallate	22-25	matrix metallopeptidase 9	Homo sapiens	144-149
9861175-13	1998	TNF-alpha concentrations decreased further 24 h after eCG injection (< 0.1 fg microgram-1 protein) and remained low until 48 h after eCG injection.	epicatechin gallate	54-57	tumor necrosis factor	Rattus norvegicus	0-9
9861175-13	1998	TNF-alpha concentrations decreased further 24 h after eCG injection (< 0.1 fg microgram-1 protein) and remained low until 48 h after eCG injection.	epicatechin gallate	136-139	tumor necrosis factor	Rattus norvegicus	0-9
9518885-7	1998	In eCG-treated animals, induction of luteolysis led to a significant increase in follicular LHr mRNA levels (P < 0.01) and a significant decrease in follicular FSHr mRNA levels (P < 0.01).	epicatechin gallate	3-6	follicle stimulating hormone receptor	Bos taurus	163-167
34718375-7	2021	PI3K/AKT/mTOR signaling pathway, which exhibits regulatory effect on lipogenesis, is also inhibited under epicatechin gallate treatment, while pretreatment with AKT activator SC79 or mTOR activator MHY1485 blocks the inhibitory effect of epicatechin gallate on the expression of lipogenic genes and the migration of prostate cancer cells.	epicatechin gallate	238-257	mechanistic target of rapamycin kinase	Homo sapiens	9-13
7828537-8	1995	In vivo priming of 25-day-old female rats for 2 days with 10 IU eCG, which promoted antral follicular growth and survival, increased levels of messenger RNA encoding SEC-SOD (216 +/- 9% of saline-treated controls, P < 0.05, n = 3) and Mn-SOD (222 +/- 14% of saline-treated controls, P < 0.05, n = 3) vs. saline-treated controls.	epicatechin gallate	64-67	superoxide dismutase 2	Rattus norvegicus	238-244
7895650-8	1995	Furthermore, immunohistochemical analysis revealed that p53 protein was localized exclusively to nuclei of apoptotic granulosa cells of atretic follicles, and that p53 immunostaining was reduced to undetectable levels after in vivo treatment with eCG.	epicatechin gallate	247-250	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	56-59
7895650-8	1995	Furthermore, immunohistochemical analysis revealed that p53 protein was localized exclusively to nuclei of apoptotic granulosa cells of atretic follicles, and that p53 immunostaining was reduced to undetectable levels after in vivo treatment with eCG.	epicatechin gallate	247-250	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	164-167
34718375-5	2021	The results indicated that epicatechin gallate downregulates the expression of acetyl-CoA carboxylase, ATP citrate lyase, and fatty acid synthase in prostate cancer cells and prostate xenograft tissues, suggesting that epicatechin gallate can inhibit de novo fatty acid synthesis.	epicatechin gallate	27-46	ATP citrate lyase	Homo sapiens	103-120
34718375-7	2021	PI3K/AKT/mTOR signaling pathway, which exhibits regulatory effect on lipogenesis, is also inhibited under epicatechin gallate treatment, while pretreatment with AKT activator SC79 or mTOR activator MHY1485 blocks the inhibitory effect of epicatechin gallate on the expression of lipogenic genes and the migration of prostate cancer cells.	epicatechin gallate	238-257	AKT serine/threonine kinase 1	Homo sapiens	161-164
34718375-5	2021	The results indicated that epicatechin gallate downregulates the expression of acetyl-CoA carboxylase, ATP citrate lyase, and fatty acid synthase in prostate cancer cells and prostate xenograft tissues, suggesting that epicatechin gallate can inhibit de novo fatty acid synthesis.	epicatechin gallate	27-46	fatty acid synthase	Homo sapiens	126-145
34718375-5	2021	The results indicated that epicatechin gallate downregulates the expression of acetyl-CoA carboxylase, ATP citrate lyase, and fatty acid synthase in prostate cancer cells and prostate xenograft tissues, suggesting that epicatechin gallate can inhibit de novo fatty acid synthesis.	epicatechin gallate	219-238	ATP citrate lyase	Homo sapiens	103-120
34718375-7	2021	PI3K/AKT/mTOR signaling pathway, which exhibits regulatory effect on lipogenesis, is also inhibited under epicatechin gallate treatment, while pretreatment with AKT activator SC79 or mTOR activator MHY1485 blocks the inhibitory effect of epicatechin gallate on the expression of lipogenic genes and the migration of prostate cancer cells.	epicatechin gallate	238-257	mechanistic target of rapamycin kinase	Homo sapiens	183-187
34718375-5	2021	The results indicated that epicatechin gallate downregulates the expression of acetyl-CoA carboxylase, ATP citrate lyase, and fatty acid synthase in prostate cancer cells and prostate xenograft tissues, suggesting that epicatechin gallate can inhibit de novo fatty acid synthesis.	epicatechin gallate	219-238	fatty acid synthase	Homo sapiens	126-145
34718375-8	2021	In conclusion, this study revealed that epicatechin gallate impairs the synthesis of fatty acids via inhibition PI3K/AKT/mTOR signaling pathway and then attenuates the migration of prostate cancer cells.	epicatechin gallate	40-59	AKT serine/threonine kinase 1	Homo sapiens	117-120
34718375-7	2021	PI3K/AKT/mTOR signaling pathway, which exhibits regulatory effect on lipogenesis, is also inhibited under epicatechin gallate treatment, while pretreatment with AKT activator SC79 or mTOR activator MHY1485 blocks the inhibitory effect of epicatechin gallate on the expression of lipogenic genes and the migration of prostate cancer cells.	epicatechin gallate	106-125	AKT serine/threonine kinase 1	Homo sapiens	5-8
34718375-8	2021	In conclusion, this study revealed that epicatechin gallate impairs the synthesis of fatty acids via inhibition PI3K/AKT/mTOR signaling pathway and then attenuates the migration of prostate cancer cells.	epicatechin gallate	40-59	mechanistic target of rapamycin kinase	Homo sapiens	121-125
34718375-7	2021	PI3K/AKT/mTOR signaling pathway, which exhibits regulatory effect on lipogenesis, is also inhibited under epicatechin gallate treatment, while pretreatment with AKT activator SC79 or mTOR activator MHY1485 blocks the inhibitory effect of epicatechin gallate on the expression of lipogenic genes and the migration of prostate cancer cells.	epicatechin gallate	106-125	mechanistic target of rapamycin kinase	Homo sapiens	9-13
34718375-7	2021	PI3K/AKT/mTOR signaling pathway, which exhibits regulatory effect on lipogenesis, is also inhibited under epicatechin gallate treatment, while pretreatment with AKT activator SC79 or mTOR activator MHY1485 blocks the inhibitory effect of epicatechin gallate on the expression of lipogenic genes and the migration of prostate cancer cells.	epicatechin gallate	238-257	AKT serine/threonine kinase 1	Homo sapiens	5-8
34229022-0	2021	Epicatechin gallate-loaded calcium alginate sponges promote diabetic wound healing through protecting against oxidative stress and modulation of immune response via PI3K/AKT/NFkappaB signaling pathway.	epicatechin gallate	0-19	AKT serine/threonine kinase 1	Rattus norvegicus	170-173
34171773-0	2021	Epicatechin gallate and epigallocatechin gallate are potent inhibitors of human arylacetamide deacetylase.	epicatechin gallate	0-19	arylacetamide deacetylase	Homo sapiens	80-105
34171773-5	2021	Curcumin and quercetin showed strong inhibitory effects against all three enzymes, whereas epicatechin, epicatechin gallate (ECg), and epigallocatechin gallate (EGCg) specifically inhibited AADAC.	epicatechin gallate	104-123	arylacetamide deacetylase	Homo sapiens	190-195
34171773-5	2021	Curcumin and quercetin showed strong inhibitory effects against all three enzymes, whereas epicatechin, epicatechin gallate (ECg), and epigallocatechin gallate (EGCg) specifically inhibited AADAC.	epicatechin gallate	125-128	arylacetamide deacetylase	Homo sapiens	190-195
34171773-6	2021	In particular, ECg and EGCg showed strong inhibitory effects on AADAC (IC50 values: 3.0 +- 0.5 and 2.2 +- 0.2 muM, respectively).	epicatechin gallate	15-18	arylacetamide deacetylase	Homo sapiens	64-69
34171773-7	2021	ECg and EGCg also strongly inhibited AADAC-mediated rifampicin hydrolase activity in human liver microsomes with IC50 values of 2.2 +- 1.4 and 1.7 +- 0.4 muM, respectively, whereas it weakly inhibited p-nitrophenyl acetate hydrolase activity, which is catalyzed by AADAC, CES1, and CES2.	epicatechin gallate	0-3	arylacetamide deacetylase	Homo sapiens	37-42
34171773-7	2021	ECg and EGCg also strongly inhibited AADAC-mediated rifampicin hydrolase activity in human liver microsomes with IC50 values of 2.2 +- 1.4 and 1.7 +- 0.4 muM, respectively, whereas it weakly inhibited p-nitrophenyl acetate hydrolase activity, which is catalyzed by AADAC, CES1, and CES2.	epicatechin gallate	0-3	arylacetamide deacetylase	Homo sapiens	265-270
34171773-7	2021	ECg and EGCg also strongly inhibited AADAC-mediated rifampicin hydrolase activity in human liver microsomes with IC50 values of 2.2 +- 1.4 and 1.7 +- 0.4 muM, respectively, whereas it weakly inhibited p-nitrophenyl acetate hydrolase activity, which is catalyzed by AADAC, CES1, and CES2.	epicatechin gallate	0-3	carboxylesterase 1	Homo sapiens	272-276
34171773-7	2021	ECg and EGCg also strongly inhibited AADAC-mediated rifampicin hydrolase activity in human liver microsomes with IC50 values of 2.2 +- 1.4 and 1.7 +- 0.4 muM, respectively, whereas it weakly inhibited p-nitrophenyl acetate hydrolase activity, which is catalyzed by AADAC, CES1, and CES2.	epicatechin gallate	0-3	carboxylesterase 2	Homo sapiens	282-286
34171773-8	2021	Our results indicate that ECg and EGCg are potent inhibitors of AADAC.	epicatechin gallate	26-29	arylacetamide deacetylase	Homo sapiens	64-69
35151167-0	2022	Multispectroscopic and synergistic antioxidant study on the combined binding of caffeic acid and (-)-epicatechin gallate to lysozyme.	epicatechin gallate	97-120	lysozyme	Homo sapiens	124-132
35151167-1	2022	The binding of caffeic acid (CA) and/or (-)-epicatechin gallate (ECG) to lysozyme was investigated by multispectroscopic methods and molecular docking.	epicatechin gallate	40-63	lysozyme	Homo sapiens	73-81
35151167-4	2022	Thermodynamic parameters indicated that CA and ECG competitively bound to lysozyme, and CA had a stronger binding affinity, which was consistent with the results of molecular docking.	epicatechin gallate	47-50	lysozyme	Homo sapiens	74-82
35151167-1	2022	The binding of caffeic acid (CA) and/or (-)-epicatechin gallate (ECG) to lysozyme was investigated by multispectroscopic methods and molecular docking.	epicatechin gallate	65-68	lysozyme	Homo sapiens	73-81
35487599-0	2022	EGCG and ECG induce apoptosis and decrease autophagy via the AMPK/mTOR and PI3K/AKT/mTOR pathway in human melanoma cells.	epicatechin gallate	9-12	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	61-65
35487599-0	2022	EGCG and ECG induce apoptosis and decrease autophagy via the AMPK/mTOR and PI3K/AKT/mTOR pathway in human melanoma cells.	epicatechin gallate	9-12	mechanistic target of rapamycin kinase	Homo sapiens	66-70
35487599-0	2022	EGCG and ECG induce apoptosis and decrease autophagy via the AMPK/mTOR and PI3K/AKT/mTOR pathway in human melanoma cells.	epicatechin gallate	9-12	AKT serine/threonine kinase 1	Homo sapiens	80-83
35487599-0	2022	EGCG and ECG induce apoptosis and decrease autophagy via the AMPK/mTOR and PI3K/AKT/mTOR pathway in human melanoma cells.	epicatechin gallate	9-12	mechanistic target of rapamycin kinase	Homo sapiens	84-88
35487599-10	2022	Mechanistically, EGCG and ECG treatments decreased phosphorylated-AMPK (p-AMPK) and increased the ratios of p-PI3K, p-AKT and p-mTOR in melanoma cells.	epicatechin gallate	26-29	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	66-70
35487599-10	2022	Mechanistically, EGCG and ECG treatments decreased phosphorylated-AMPK (p-AMPK) and increased the ratios of p-PI3K, p-AKT and p-mTOR in melanoma cells.	epicatechin gallate	26-29	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	74-78
35487599-10	2022	Mechanistically, EGCG and ECG treatments decreased phosphorylated-AMPK (p-AMPK) and increased the ratios of p-PI3K, p-AKT and p-mTOR in melanoma cells.	epicatechin gallate	26-29	AKT serine/threonine kinase 1	Homo sapiens	118-121
35487599-10	2022	Mechanistically, EGCG and ECG treatments decreased phosphorylated-AMPK (p-AMPK) and increased the ratios of p-PI3K, p-AKT and p-mTOR in melanoma cells.	epicatechin gallate	26-29	mechanistic target of rapamycin kinase	Homo sapiens	128-132
35487599-11	2022	Conclusively, EGCG and ECG induced apoptosis via mitochondrial signaling pathway, downregulated autophagy through modulating the AMPK/mTOR and PI3K/AKT/mTOR signaling pathway.	epicatechin gallate	23-26	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	129-133
35487599-11	2022	Conclusively, EGCG and ECG induced apoptosis via mitochondrial signaling pathway, downregulated autophagy through modulating the AMPK/mTOR and PI3K/AKT/mTOR signaling pathway.	epicatechin gallate	23-26	mechanistic target of rapamycin kinase	Homo sapiens	134-138
35487599-11	2022	Conclusively, EGCG and ECG induced apoptosis via mitochondrial signaling pathway, downregulated autophagy through modulating the AMPK/mTOR and PI3K/AKT/mTOR signaling pathway.	epicatechin gallate	23-26	AKT serine/threonine kinase 1	Homo sapiens	148-151
35487599-11	2022	Conclusively, EGCG and ECG induced apoptosis via mitochondrial signaling pathway, downregulated autophagy through modulating the AMPK/mTOR and PI3K/AKT/mTOR signaling pathway.	epicatechin gallate	23-26	mechanistic target of rapamycin kinase	Homo sapiens	152-156