PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
20088527-1	2010	AlX(3) (X = Cl or Br) and PMes(3) (Mes = 2,4,6-C(6)H(2)Me(3)) react to form weak Lewis adducts but also react with CO(2) to give Mes(3)P(CO(2))(AlX(3))(2) (X = Cl; Br).	co(2)	115-120	ALX homeobox 3	Homo sapiens	0-6
19895395-6	2010	The chloroplast CO(2) concentration (C(trans)) at which the transition from RuBP carboxylation to RuBP regeneration limitation occurred increased with leaf temperature and was independent of growth light intensity, consistent with the constant ratio of cyt f/Rubisco.	co(2)	16-21	apocytochrome f precursor	Nicotiana tabacum	253-258
19842162-2	2010	Previous work demonstrated that AQP1 is permeable to both CO(2) and O(2).	co(2)	58-63	aquaporin 1 (Colton blood group)	Homo sapiens	32-36
20142480-2	2010	Grasses possess two main photosynthetic pathways: the C(3) pathway that is typical of most plants and a specialized C(4) pathway that minimizes photorespiration and thus increases photosynthetic performance in high-temperature and/or low-CO(2) environments.	co(2)	238-243	complement C4A (Rodgers blood group)	Homo sapiens	116-120
21096927-4	2010	CO(2) is provided by a cylinder that delivers a stable flux, which is converted to a pulsatile mode through a high frequency solenoid valve that can chop it up to 1 kHz.	co(2)	0-5	DNA damage inducible transcript 3	Homo sapiens	149-153
19879980-1	2010	The soluble enzyme carbonic anhydrase II (CAII) plays an important role in CO(2) influx and efflux by red blood cells (RBCs), a process initiated by changes in the extracellular [CO(2)] (CO(2)-initiated CO(2) transport).	co(2)	75-80	carbonic anhydrase 2	Homo sapiens	42-46
19879980-1	2010	The soluble enzyme carbonic anhydrase II (CAII) plays an important role in CO(2) influx and efflux by red blood cells (RBCs), a process initiated by changes in the extracellular [CO(2)] (CO(2)-initiated CO(2) transport).	co(2)	179-184	carbonic anhydrase 2	Homo sapiens	42-46
19879980-1	2010	The soluble enzyme carbonic anhydrase II (CAII) plays an important role in CO(2) influx and efflux by red blood cells (RBCs), a process initiated by changes in the extracellular [CO(2)] (CO(2)-initiated CO(2) transport).	co(2)	179-184	carbonic anhydrase 2	Homo sapiens	42-46
19879980-1	2010	The soluble enzyme carbonic anhydrase II (CAII) plays an important role in CO(2) influx and efflux by red blood cells (RBCs), a process initiated by changes in the extracellular [CO(2)] (CO(2)-initiated CO(2) transport).	co(2)	179-184	carbonic anhydrase 2	Homo sapiens	42-46
19879980-5	2010	In this review, I assess the theoretical roles of CAs in the transport of CO(2) and HCO(3)(-)-related species, concluding that although the effect of bound CAII on CO(2)-initiated CO(2) transport is expected to be substantial, the effect of bound CAs on HCO(3)(-)-initiated HCO(3)(-) transport is expected to be modest at best.	co(2)	74-79	carbonic anhydrase 2	Homo sapiens	156-160
19879980-5	2010	In this review, I assess the theoretical roles of CAs in the transport of CO(2) and HCO(3)(-)-related species, concluding that although the effect of bound CAII on CO(2)-initiated CO(2) transport is expected to be substantial, the effect of bound CAs on HCO(3)(-)-initiated HCO(3)(-) transport is expected to be modest at best.	co(2)	164-169	carbonic anhydrase 2	Homo sapiens	156-160
19879980-5	2010	In this review, I assess the theoretical roles of CAs in the transport of CO(2) and HCO(3)(-)-related species, concluding that although the effect of bound CAII on CO(2)-initiated CO(2) transport is expected to be substantial, the effect of bound CAs on HCO(3)(-)-initiated HCO(3)(-) transport is expected to be modest at best.	co(2)	164-169	carbonic anhydrase 2	Homo sapiens	156-160
20054711-5	2010	In ndhM pgr5, the transient was absent even in CO(2)-free air with 2% O(2), demonstrating that the post-illumination transient can also be induced by the Fd- (or PGR5)-dependent PQ reduction.	co(2)	47-52	proton gradient regulation 5	Arabidopsis thaliana	8-12
20054711-5	2010	In ndhM pgr5, the transient was absent even in CO(2)-free air with 2% O(2), demonstrating that the post-illumination transient can also be induced by the Fd- (or PGR5)-dependent PQ reduction.	co(2)	47-52	proton gradient regulation 5	Arabidopsis thaliana	162-166
20000734-4	2010	We report crystal structures in the three important hydrate crystal classes, sI, sII, and sH, for the guests CO(2), C(2)H(6), C(3)H(8), and methylcyclohexane + CH(4).	co(2)	109-114	transcription elongation factor A1	Homo sapiens	81-84
19996183-4	2010	Here we show that high concentration TNFalpha in the hypothalamus leads to increased O(2) consumption/CO(2) production, increased body temperature, and reduced caloric intake, resulting in loss of body mass.	co(2)	102-107	tumor necrosis factor	Rattus norvegicus	37-45
19995618-3	2010	We studied the effects on ventilation in air and in 7% CO(2) of focal antagonism of OX(1)R in the rostral MR by microdialysis of SB-334867 in rats during wakefulness and NREM sleep, under dark and light periods.	co(2)	55-60	hypocretin receptor 1	Rattus norvegicus	84-90
20080721-1	2010	Quantifying atmospheric CO(2) concentrations ([CO(2)](atm)) during Earth"s ancient greenhouse episodes is essential for accurately predicting the response of future climate to elevated CO(2) levels.	co(2)	24-29	ATM serine/threonine kinase	Homo sapiens	12-15
20080721-1	2010	Quantifying atmospheric CO(2) concentrations ([CO(2)](atm)) during Earth"s ancient greenhouse episodes is essential for accurately predicting the response of future climate to elevated CO(2) levels.	co(2)	47-52	ATM serine/threonine kinase	Homo sapiens	12-15
20080721-1	2010	Quantifying atmospheric CO(2) concentrations ([CO(2)](atm)) during Earth"s ancient greenhouse episodes is essential for accurately predicting the response of future climate to elevated CO(2) levels.	co(2)	47-52	ATM serine/threonine kinase	Homo sapiens	12-15
20080721-2	2010	Empirical estimates of [CO(2)](atm) during Paleozoic and Mesozoic greenhouse climates are based primarily on the carbon isotope composition of calcium carbonate in fossil soils.	co(2)	24-29	ATM serine/threonine kinase	Homo sapiens	31-34
20080721-3	2010	We report that greenhouse [CO(2)](atm) have been significantly overestimated because previously assumed soil CO(2) concentrations during carbonate formation are too high.	co(2)	27-32	ATM serine/threonine kinase	Homo sapiens	34-37
20080721-3	2010	We report that greenhouse [CO(2)](atm) have been significantly overestimated because previously assumed soil CO(2) concentrations during carbonate formation are too high.	co(2)	109-114	ATM serine/threonine kinase	Homo sapiens	34-37
20080721-4	2010	More accurate [CO(2)](atm), resulting from better constraints on soil CO(2), indicate that large (1,000s of ppmV) fluctuations in [CO(2)](atm) did not characterize ancient climates and that past greenhouse climates were accompanied by concentrations similar to those projected for A.D. 2100.	co(2)	15-20	ATM serine/threonine kinase	Homo sapiens	22-25
20080721-4	2010	More accurate [CO(2)](atm), resulting from better constraints on soil CO(2), indicate that large (1,000s of ppmV) fluctuations in [CO(2)](atm) did not characterize ancient climates and that past greenhouse climates were accompanied by concentrations similar to those projected for A.D. 2100.	co(2)	70-75	ATM serine/threonine kinase	Homo sapiens	22-25
20080721-4	2010	More accurate [CO(2)](atm), resulting from better constraints on soil CO(2), indicate that large (1,000s of ppmV) fluctuations in [CO(2)](atm) did not characterize ancient climates and that past greenhouse climates were accompanied by concentrations similar to those projected for A.D. 2100.	co(2)	70-75	ATM serine/threonine kinase	Homo sapiens	22-25
20118557-2	2010	The effect of timolol hemihydrate on the CO(2) hydration activities of human carbonic anhydrase (HCA) I and II and their reaction mechanisms were investigated.	co(2)	41-46	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	77-110
20819061-1	2010	The beta-carbonic anhydrase from Saccharomyces cerevisiae (CA, EC 4.2.1.1), scCA, which is encoded by the Nce103 gene, is an effective catalyst for CO(2) hydration to bicarbonate and protons, with a k(cat) of 9.4 x 10(5) s(-1), and k(cat)/K(M) of 9.8 x 10(7) M(-1).s(-1).	co(2)	148-153	carbonate dehydratase NCE103	Saccharomyces cerevisiae S288C	106-112
19884319-7	2009	Inhibiting pannexin 1 gap junction hemichannels with CO(2)-saturated buffer or probenecid significantly reduced cell-cell signalling between receptor cells and presynaptic cells.	co(2)	53-58	pannexin 1	Homo sapiens	11-21
21576865-3	2010	On a per-cell basis, this biomass production was at least an order of magnitude higher than the CO(2) uptake rate calculated for a photosynthetic mat dominated by thermophilic Synechococcus spp.	co(2)	96-101	histocompatibility minor 13	Homo sapiens	190-193
19939947-2	2010	The tobacco stress-induced Aquaporin1 (NtAQP1) functions as both water and CO(2) channel.	co(2)	75-80	probable aquaporin TIP1-1	Nicotiana tabacum	27-37
19939947-2	2010	The tobacco stress-induced Aquaporin1 (NtAQP1) functions as both water and CO(2) channel.	co(2)	75-80	probable aquaporin TIP1-1	Nicotiana tabacum	39-45
19939947-3	2010	In tobacco plants, overexpression of NtAQP1 increases leaf net photosynthesis (A(N)), mesophyll CO(2) conductance, and stomatal conductance, whereas its silencing reduces root hydraulic conductivity (L(p)).	co(2)	96-101	probable aquaporin TIP1-1	Nicotiana tabacum	37-43
20023869-1	2009	Theoretical studies on Co(2)(CO)(6)(PX)(2) derivatives (X = H, Cl, OH, OMe, NH(2), NMe(2)) predict the lowest energy structures to be butterfly structures containing five two-electron two-center bonds in the central Co(2)P(2) unit.	co(2)	23-28	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	83-89
20023869-3	2009	In addition, for Co(2)(CO)(6)(POR)(2) (R = H, Me) still higher energy "diphosphine" structures are also found containing only three rather than four Co-P bonds, one P-P bond, and no Co...Co bond.	co(2)	17-22	cytochrome p450 oxidoreductase	Homo sapiens	30-33
19828835-5	2009	Fe(2)Tf, Co(2)Tf, and Mn(2)Tf increased TFR2 protein expression, indicating that the upregulation was not specifically regulated by iron-transferrin but also other metal-transferrins.	co(2)	9-14	transferrin receptor 2	Homo sapiens	40-44
19828835-5	2009	Fe(2)Tf, Co(2)Tf, and Mn(2)Tf increased TFR2 protein expression, indicating that the upregulation was not specifically regulated by iron-transferrin but also other metal-transferrins.	co(2)	9-14	transferrin	Homo sapiens	137-148
19828835-6	2009	In addition, Co(2)Tf and Mn(2)Tf upregulated TFR1, reduced ferritin, and increased hypoxia-inducible factor-1alpha protein expression, suggesting that TFR1 upregulation was due to a combination of iron deficiency and chemical hypoxia.	co(2)	13-18	transferrin receptor	Homo sapiens	45-49
19828835-6	2009	In addition, Co(2)Tf and Mn(2)Tf upregulated TFR1, reduced ferritin, and increased hypoxia-inducible factor-1alpha protein expression, suggesting that TFR1 upregulation was due to a combination of iron deficiency and chemical hypoxia.	co(2)	13-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	83-114
19828835-6	2009	In addition, Co(2)Tf and Mn(2)Tf upregulated TFR1, reduced ferritin, and increased hypoxia-inducible factor-1alpha protein expression, suggesting that TFR1 upregulation was due to a combination of iron deficiency and chemical hypoxia.	co(2)	13-18	transferrin receptor	Homo sapiens	151-155
19775141-2	2009	The TGA analysis of the NHC-CO(2)"s shows that as steric bulk on the N-substituent increases, the ability of the NHC-CO(2) to decarboxylate increases.	co(2)	28-33	T-box transcription factor 1	Homo sapiens	4-7
19734142-3	2009	Data were obtained at 22.0 degrees C. HSA-heme-Fe(III) catalyzes peroxynitrite isomerization in the absence and presence of CO(2); the values of the second order catalytic rate constant (k(on)) are 4.1 x 10(5) and 4.5 x 10(5) m(-1) s(-1), respectively.	co(2)	124-129	albumin	Homo sapiens	38-41
19692653-10	2009	Association of AE3 and CAXIV may represent a mechanism to enhance disposal of waste CO(2) and to balance pH in excitable tissues.	co(2)	84-89	solute carrier family 4 (anion exchanger), member 3	Mus musculus	15-18
19692653-10	2009	Association of AE3 and CAXIV may represent a mechanism to enhance disposal of waste CO(2) and to balance pH in excitable tissues.	co(2)	84-89	carbonic anhydrase 14	Mus musculus	23-28
19769368-2	2009	Gene expression of a class I chitinase (Vcchit1b) in the skin of table grapes was analyzed as a molecular marker for changes induced at low temperature and also to study the effect of high CO(2) levels modulating transcript levels at 0 degrees C. An active recombinant VcCHIT1b was overexpressed in Escherichia coli, and as the protein was produced as insoluble inclusion bodies, it was solubilized and refolded.	co(2)	189-194	acidic endochitinase	Vitis vinifera	29-38
19622787-4	2009	In this setting, increasing concentrations of amino acids dose-dependently reduced the insulin-stimulated rates of CO(2) production from glucose and palmitate (decrease in glucose oxidation induced by addition of 5.5, 11, 22, and 44 mmol/l amino acids:--16 +/- 3, -25 +/- 7, -44 +/- 4, -62 +/- 4%; P < 0.02 each).	co(2)	115-120	insulin	Homo sapiens	87-94
19823239-9	2009	A comparison of direct absorption and 1f-normalized, WMS-2f shows a factor of 4 increase in signal-to-noise ratio with the WMS technique for measurements of CO(2) in the supersonic flow.	co(2)	157-162	fibrillin 1	Homo sapiens	53-58
19376650-4	2009	Based on the limitation of a total volume of 30 mL purging SCF-CO(2) for economical considerations, the optimum conditions can be summarized as follows: 120 degrees C, oven temperature; 350 atm, CO(2) pressure; 0.2 mL of ethylacetate spiking to SCF-CO(2); 2.0 min, static equilibrium time; and five cycles of dynamic flow pausing.	co(2)	63-68	KIT ligand	Homo sapiens	59-62
19560334-2	2009	In laboratory incubations, CH(4) production rates from anoxic soil slurries were significantly reduced at amendment levels of 0.5%, 1%, 2% and 5% (wt wt(-1)), while observed CO(2) production rates were enhanced.	co(2)	174-179	COP9 signalosome subunit 4	Drosophila melanogaster	27-32
19651649-4	2009	Evidence from human genetics, neurophysiology and mouse reverse genetics converges to implicate a small population of Phox2b-dependent neurons, located in the retrotrapezoid nucleus, in the detection of CO(2), which is a paramount source of the "drive to breathe".	co(2)	203-208	paired-like homeobox 2b	Mus musculus	118-124
20633492-4	2009	Transcutaneous CO(2) emission is significantly higher at P7 and P3, than the control points beside them.	co(2)	15-20	solute carrier family 10 member 7	Homo sapiens	57-66
19796482-6	2009	We have applied in situ attenuated total reflection infrared (ATR-IR) spectroscopy for elucidating and monitoring the acetalization of cyclohexanone in CO(2)-expanded ethylene glycol and methanol at 50 degrees C and 3 MPa.	co(2)	152-157	ATR serine/threonine kinase	Homo sapiens	62-65
19796482-9	2009	The ZnSe ATR crystal, however, was corroded during longer use under the acidic conditions realized by the dissolution of CO(2) in the alcohols.	co(2)	121-126	ATR serine/threonine kinase	Homo sapiens	9-12
19570105-2	2009	In these ecosystems, groundwater level (GWL) and temperature, two factors likely to be altered by climate change, exert important control over CO(2), CH(4) and N(2)O fluxes.	co(2)	143-148	microtubule associated serine/threonine kinase like	Homo sapiens	40-43
19570105-12	2009	This substantial GWL-effect on the Q(10) of CH(4) and N(2)O emissions was, however, hardly reflected in the Q(10) of the total GHG emissions (which varied around 2), because the contribution of these gases was relatively small compared to that of CO(2).	co(2)	247-252	microtubule associated serine/threonine kinase like	Homo sapiens	17-20
19538945-5	2009	Local pretreatment with non-vasoactive doses of PACAP (10(-8) M) and VIP (10(-9) M) prevented the attenuation of postischemic CR to hypercapnia; to 10% CO(2), the CR values were 27+/-8% vs 92+/-5% vs 88+/-13% (vehicle vs PACAP38 vs VIP, CR expressed as a percentage of the response before I/R, mean+/-SEM, n=8-8, p<0.05).	co(2)	152-157	adenylate cyclase activating polypeptide 1	Sus scrofa	48-53
21255289-6	2009	Depending on the in situ conditions the energetically most favourable pathway for the PAH-degrading organisms is oxidation to H(2)/CO(2) or conversion into acetate.	co(2)	131-136	phenylalanine hydroxylase	Homo sapiens	86-89
19712903-2	2009	The retrotrapezoid nucleus (RTN), a group of glutamatergic neurons that express the transcription factor Phox2b, may be a crucial nodal point through which breathing automaticity is regulated to maintain CO(2) constant.	co(2)	204-209	paired-like homeobox 2b	Rattus norvegicus	105-111
19712905-2	2009	Its role in the control of respiration has been highlighted by the identification of heterozygous PHOX2B mutations as the cause of Central Congenital Hypoventilation Syndrome (CCHS), a rare disease defined by the lack of CO(2) responsiveness and of breathing automaticity in sleep.	co(2)	221-226	paired-like homeobox 2b	Mus musculus	98-104
19623397-5	2009	The CO(2) insertion reactions of the para-substituted phenyl carbamate complexes Ti(eta-C(5)Me(5)){N(-4-C(6)H(4)X)C(O)O}{MeC(N(i)Pr)(2)} (X = Me, CF(3) or NMe(2)) were first order with respect to both carbamate complex and CO(2) and the pseudo first order rate constants were effectively independent of the para substituent.	co(2)	4-9	C-C motif chemokine ligand 28	Homo sapiens	121-124
19583303-1	2009	Human carbonic anhydrase II (HCA II) is a monomeric zinc-containing metalloenzyme that catalyzes the hydration of CO(2) to form bicarbonate and a proton.	co(2)	114-119	carbonic anhydrase 2	Homo sapiens	6-27
19538945-5	2009	Local pretreatment with non-vasoactive doses of PACAP (10(-8) M) and VIP (10(-9) M) prevented the attenuation of postischemic CR to hypercapnia; to 10% CO(2), the CR values were 27+/-8% vs 92+/-5% vs 88+/-13% (vehicle vs PACAP38 vs VIP, CR expressed as a percentage of the response before I/R, mean+/-SEM, n=8-8, p<0.05).	co(2)	152-157	vasoactive intestinal peptide	Sus scrofa	69-72
19438202-5	2009	Topological analysis of the static electron density of u-1 suggests that there is direct metal-metal bonding for both the shorter Co(1)-Co(2) and the longer Co(2)-Co(3) contact.	co(2)	157-162	RNA, U1 small nuclear 1	Homo sapiens	55-58
19522021-6	2009	RESULTS: The expression of E-cadherin, ICAM-1, CD44 and E-selectin in SW1116 cells were changed significantly following exposure to CO(2) insufflation at different pressures (P < 0.05).	co(2)	132-137	cadherin 1	Homo sapiens	27-37
19522021-6	2009	RESULTS: The expression of E-cadherin, ICAM-1, CD44 and E-selectin in SW1116 cells were changed significantly following exposure to CO(2) insufflation at different pressures (P < 0.05).	co(2)	132-137	intercellular adhesion molecule 1	Homo sapiens	39-45
19522021-6	2009	RESULTS: The expression of E-cadherin, ICAM-1, CD44 and E-selectin in SW1116 cells were changed significantly following exposure to CO(2) insufflation at different pressures (P < 0.05).	co(2)	132-137	CD44 molecule (Indian blood group)	Homo sapiens	47-51
19522021-6	2009	RESULTS: The expression of E-cadherin, ICAM-1, CD44 and E-selectin in SW1116 cells were changed significantly following exposure to CO(2) insufflation at different pressures (P < 0.05).	co(2)	132-137	selectin E	Homo sapiens	56-66
19522021-7	2009	The expression of E-cadherin, CD44 and ICAM-1 decreased with increasing CO(2)-insufflation pressure.	co(2)	72-77	cadherin 1	Homo sapiens	18-28
19522021-7	2009	The expression of E-cadherin, CD44 and ICAM-1 decreased with increasing CO(2)-insufflation pressure.	co(2)	72-77	CD44 molecule (Indian blood group)	Homo sapiens	30-34
19522021-7	2009	The expression of E-cadherin, CD44 and ICAM-1 decreased with increasing CO(2)-insufflation pressure.	co(2)	72-77	intercellular adhesion molecule 1	Homo sapiens	39-45
19458084-6	2009	The observation that CA9 activity reversibly reduces pH(e) indicates the enzyme is facilitating CO(2) excretion from cells (by converting vented CO(2) to extracellular H(+)), rather than facilitating membrane H(+) transport (such as H(+) associated with metabolically generated lactic acid).	co(2)	96-101	carbonic anhydrase 9	Homo sapiens	21-24
19458084-6	2009	The observation that CA9 activity reversibly reduces pH(e) indicates the enzyme is facilitating CO(2) excretion from cells (by converting vented CO(2) to extracellular H(+)), rather than facilitating membrane H(+) transport (such as H(+) associated with metabolically generated lactic acid).	co(2)	145-150	carbonic anhydrase 9	Homo sapiens	21-24
19458084-8	2009	In a multicellular structure, the net effect of CA9 on pH(e) will depend on the cellular CO(2)/lactic acid emission ratio (set by local oxygenation and membrane HCO(3)(-) uptake).	co(2)	89-94	carbonic anhydrase 9	Homo sapiens	48-51
19458084-9	2009	Our results suggest that CO(2)-producing tumors may express CA9 to facilitate CO(2) excretion, thus raising pH(i) and reducing pH(e), which promotes tumor proliferation and survival.	co(2)	25-30	carbonic anhydrase 9	Homo sapiens	60-63
19458084-9	2009	Our results suggest that CO(2)-producing tumors may express CA9 to facilitate CO(2) excretion, thus raising pH(i) and reducing pH(e), which promotes tumor proliferation and survival.	co(2)	78-83	carbonic anhydrase 9	Homo sapiens	60-63
19507824-1	2009	A new polynuclear azido-bridged Co(II) compound with formula [Co(2)(N(3))(4)(HMTA)(H(2)O)](n) (1) (HMTA = hexamethylenetetramine) has been structurally and magnetically characterized.	co(2)	62-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
19523599-1	2009	The NADP-dependent malic enzyme (NADP-ME; EC1.1.1.40) found in many metabolic pathways catalyzes the oxidative decarboxylation of L-malate, producing pyruvate, CO(2) and NADPH.	co(2)	160-165	NADP-dependent malic enzyme, chloroplastic	Triticum aestivum	4-31
19523599-1	2009	The NADP-dependent malic enzyme (NADP-ME; EC1.1.1.40) found in many metabolic pathways catalyzes the oxidative decarboxylation of L-malate, producing pyruvate, CO(2) and NADPH.	co(2)	160-165	NADP-dependent malic enzyme, chloroplastic	Triticum aestivum	33-40
19361580-3	2009	FATP1 strongly stimulates CO(2) production from glucose whereas nonmitochondrial metabolism of glucose is only slightly enhanced.	co(2)	26-31	solute carrier family 27 member 1	Homo sapiens	0-5
19438202-5	2009	Topological analysis of the static electron density of u-1 suggests that there is direct metal-metal bonding for both the shorter Co(1)-Co(2) and the longer Co(2)-Co(3) contact.	co(2)	136-141	RNA, U1 small nuclear 1	Homo sapiens	55-58
19265705-2	2009	4.1.1.12) is a pyridoxal-5"-phosphate (PLP)-dependent enzyme that catalyzes the beta-decarboxylation of l-aspartate to produce l-alanine and CO(2).	co(2)	141-146	pyridoxal phosphatase	Homo sapiens	15-37
19213929-3	2009	When exposed to 97% N(2)-3% CO(2) on postnatal day 4.5, unanesthetized Pet-1(-/-) mice required over four times longer than age-matched wild-type controls to initiate gasping following primary apnea.	co(2)	28-33	plasmacytoma expressed transcript 1	Mus musculus	71-76
19211719-1	2009	Cerebral blood flow (CBF) and its distribution are highly sensitive to changes in the partial pressure of arterial CO(2) (Pa(CO(2))).	co(2)	115-120	complement C2	Homo sapiens	122-131
19273574-1	2009	Recent data from transgenic mice suggest that orexin plays an important role in the ventilatory response to CO(2) during wakefulness.	co(2)	108-113	hypocretin	Mus musculus	46-52
19442935-6	2009	Although current methodology cannot differentiate between direct effect of CO(2) on the orexin-containing neurons and indirect one through other neurons, this is the first report showing that inhalation of CO(2) did activate the orexin-containing neurons in vivo.	co(2)	206-211	hypocretin	Mus musculus	88-94
19442935-6	2009	Although current methodology cannot differentiate between direct effect of CO(2) on the orexin-containing neurons and indirect one through other neurons, this is the first report showing that inhalation of CO(2) did activate the orexin-containing neurons in vivo.	co(2)	206-211	hypocretin	Mus musculus	229-235
19265705-2	2009	4.1.1.12) is a pyridoxal-5"-phosphate (PLP)-dependent enzyme that catalyzes the beta-decarboxylation of l-aspartate to produce l-alanine and CO(2).	co(2)	141-146	pyridoxal phosphatase	Homo sapiens	39-42
18848533-1	2009	FDH (10-formyltetrahydrofolate dehydrogenase, Aldh1L1, EC 1.5.1.6) converts 10-formyltetrahydrofolate (10-formyl-THF) to tetrahydrofolate and CO(2) in a NADP(+)-dependent reaction.	co(2)	142-147	aldehyde dehydrogenase 1 family member L1	Homo sapiens	0-3
19368885-1	2009	The type-I PLP enzyme l-aspartate beta-decarboxylase converts aspartate to alanine and CO(2).	co(2)	87-92	proteolipid protein 1	Homo sapiens	11-14
19355744-2	2009	The He-CO(2) interaction potential of Ran and Xie [J. Chem.	co(2)	7-12	RAN, member RAS oncogene family	Homo sapiens	38-41
19273840-1	2009	The water channel aquaporin 1 (AQP1) and certain Rh-family members are permeable to CO(2) and NH(3).	co(2)	84-89	aquaporin 1	Rattus norvegicus	31-35
19273840-3	2009	Exposed to CO(2) or NH(3), AQP1 oocytes exhibit a greater maximal magnitude of pH(S) change (DeltapH(S)) compared with day-matched controls injected with H(2)O or with RNA encoding SGLT1, NKCC2, or PepT1.	co(2)	11-16	aquaporin 1	Rattus norvegicus	27-31
19273840-3	2009	Exposed to CO(2) or NH(3), AQP1 oocytes exhibit a greater maximal magnitude of pH(S) change (DeltapH(S)) compared with day-matched controls injected with H(2)O or with RNA encoding SGLT1, NKCC2, or PepT1.	co(2)	11-16	solute carrier family 5 member 1	Rattus norvegicus	181-186
19273840-4	2009	With CO(2), AQP1 oocytes also have faster time constants for pH(S) relaxation (tau(pHs)).	co(2)	5-10	aquaporin 1	Rattus norvegicus	12-16
19273840-5	2009	Thus, AQP1, but not the other proteins, conduct CO(2) and NH(3).	co(2)	48-53	aquaporin 1	Rattus norvegicus	6-10
19273840-6	2009	Oocytes expressing rat AQP4, rat AQP5, human RhAG, or the bacterial Rh homolog AmtB also exhibit greater DeltapH(S)(CO(2)) and faster tau(pHs) compared with controls.	co(2)	116-121	aquaporin 4	Rattus norvegicus	23-27
19273840-6	2009	Oocytes expressing rat AQP4, rat AQP5, human RhAG, or the bacterial Rh homolog AmtB also exhibit greater DeltapH(S)(CO(2)) and faster tau(pHs) compared with controls.	co(2)	116-121	aquaporin 5	Rattus norvegicus	33-37
19273840-6	2009	Oocytes expressing rat AQP4, rat AQP5, human RhAG, or the bacterial Rh homolog AmtB also exhibit greater DeltapH(S)(CO(2)) and faster tau(pHs) compared with controls.	co(2)	116-121	Rh associated glycoprotein	Homo sapiens	45-49
19273840-11	2009	For DeltapH(S)(CO(2))*/DeltapH(S)(NH(3))*, the sequence was AQP4 congruent with AQP5 > AQP1 > AmtB > RhAG.	co(2)	15-20	aquaporin 4	Rattus norvegicus	60-64
19273840-11	2009	For DeltapH(S)(CO(2))*/DeltapH(S)(NH(3))*, the sequence was AQP4 congruent with AQP5 > AQP1 > AmtB > RhAG.	co(2)	15-20	aquaporin 5	Rattus norvegicus	80-84
19273840-11	2009	For DeltapH(S)(CO(2))*/DeltapH(S)(NH(3))*, the sequence was AQP4 congruent with AQP5 > AQP1 > AmtB > RhAG.	co(2)	15-20	aquaporin 1	Rattus norvegicus	90-94
19321421-3	2009	Here we investigated whether the limiting-CO(2)-inducible, putative ABC-type transporter HLA3 might function as a HCO(3)(-) transporter by evaluating the effect of pH on growth, photosynthetic Ci affinity, and [(14)C]-Ci uptake in very low CO(2) conditions following RNA interference (RNAi) knockdown of HLA3 mRNA levels in wild-type and mutant cells.	co(2)	42-47	uncharacterized protein	Chlamydomonas reinhardtii	89-93
19321421-3	2009	Here we investigated whether the limiting-CO(2)-inducible, putative ABC-type transporter HLA3 might function as a HCO(3)(-) transporter by evaluating the effect of pH on growth, photosynthetic Ci affinity, and [(14)C]-Ci uptake in very low CO(2) conditions following RNA interference (RNAi) knockdown of HLA3 mRNA levels in wild-type and mutant cells.	co(2)	42-47	uncharacterized protein	Chlamydomonas reinhardtii	304-308
19321421-3	2009	Here we investigated whether the limiting-CO(2)-inducible, putative ABC-type transporter HLA3 might function as a HCO(3)(-) transporter by evaluating the effect of pH on growth, photosynthetic Ci affinity, and [(14)C]-Ci uptake in very low CO(2) conditions following RNA interference (RNAi) knockdown of HLA3 mRNA levels in wild-type and mutant cells.	co(2)	240-245	uncharacterized protein	Chlamydomonas reinhardtii	89-93
19244382-2	2009	CO(2) also can be generated from the 2-carbon of glycine by 10-formyltetrahydrofolate-dehydrogenase and, after glycine-to-serine conversion by serine hydroxymethyltransferase, from the tricarboxylic acid cycle.	co(2)	0-5	aldehyde dehydrogenase 1 family member L1	Homo sapiens	60-99
18848533-1	2009	FDH (10-formyltetrahydrofolate dehydrogenase, Aldh1L1, EC 1.5.1.6) converts 10-formyltetrahydrofolate (10-formyl-THF) to tetrahydrofolate and CO(2) in a NADP(+)-dependent reaction.	co(2)	142-147	aldehyde dehydrogenase 1 family member L1	Homo sapiens	5-44
18848533-1	2009	FDH (10-formyltetrahydrofolate dehydrogenase, Aldh1L1, EC 1.5.1.6) converts 10-formyltetrahydrofolate (10-formyl-THF) to tetrahydrofolate and CO(2) in a NADP(+)-dependent reaction.	co(2)	142-147	aldehyde dehydrogenase 1 family member L1	Homo sapiens	46-53
19825619-4	2009	Compared to cat2 at elevated CO(2) or wild-type plants in any condition, transfer of cat2 to air in both photoperiods caused measurable oxidation of the leaf glutathione pool within hours.	co(2)	29-34	cationic amino acid transporter 2	Arabidopsis thaliana	85-89
19285466-4	2009	One gene, npr-1, encodes a previously described neuropeptide receptor whose high activity in N2 promotes CO(2) avoidance.	co(2)	105-110	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	10-15
19285466-5	2009	The second gene, glb-5, encodes a neuronal globin domain protein whose high activity in CB4856 modifies behavioral responses to O(2) and combined O(2)/CO(2) stimuli.	co(2)	151-156	GLOBIN domain-containing protein	Caenorhabditis elegans	17-22
19144536-5	2009	The most severe phenotype of hma1 could be observed in high (0.1%) CO(2) concentrations, indicating that hma1 has the defect other than photorespiration.	co(2)	67-72	heavy metal atpase 1	Arabidopsis thaliana	29-33
19144536-5	2009	The most severe phenotype of hma1 could be observed in high (0.1%) CO(2) concentrations, indicating that hma1 has the defect other than photorespiration.	co(2)	67-72	heavy metal atpase 1	Arabidopsis thaliana	105-109
19144536-8	2009	Under high CO(2) condition, hma1 exhibited slightly higher NPQ induction than wild type plants, while this increase of NPQ in hma1 was suppressed when hma1 was crossed with crr2 having a defect in NDH-mediated PSI cyclic electron flow.	co(2)	11-16	heavy metal atpase 1	Arabidopsis thaliana	28-32
18842297-0	2009	The fabrication of elastin-based hydrogels using high pressure CO(2).	co(2)	63-68	elastin	Homo sapiens	19-26
19181845-4	2009	Here, we show that bicarbonate activates cGMP-producing ability of guanylyl cyclase-D (GC-D), a membrane GC exclusively expressed in the CO(2)-responsive OSNs, by directly acting on the intracellular cyclase domain of GC-D.	co(2)	137-142	guanylate cyclase 2d	Mus musculus	67-85
19536486-3	2009	Because CO(2)/HCO(3) mediates depolarization in chemoreceptors, we hypothesized that sAC mRNA would be expressed in the CB, and its expression and function would be regulated by CO(2)/HCO(3).Sprague-Dawley rats at postnatal days 16-17 were used to compare sAC mRNA gene expression between CB and non-chemosensitive tissues: superior cervical (SCG), petrosal (PG) and nodose ganglia (NG) by quantitative real time-PCR.	co(2)	8-13	adenylate cyclase 10	Rattus norvegicus	85-88
19536486-3	2009	Because CO(2)/HCO(3) mediates depolarization in chemoreceptors, we hypothesized that sAC mRNA would be expressed in the CB, and its expression and function would be regulated by CO(2)/HCO(3).Sprague-Dawley rats at postnatal days 16-17 were used to compare sAC mRNA gene expression between CB and non-chemosensitive tissues: superior cervical (SCG), petrosal (PG) and nodose ganglia (NG) by quantitative real time-PCR.	co(2)	178-183	adenylate cyclase 10	Rattus norvegicus	85-88
19014985-2	2009	The GEDD effect of the core tablet was achieved using CO(2) gas to push insulin together with the mucoadhesive excipients poly(ethyleneoxide) (PEO) and the permeation enhancer trimethyl chitosan (TMC) to the surface of the small intestine.	co(2)	54-59	insulin	Oryctolagus cuniculus	72-79
19181845-4	2009	Here, we show that bicarbonate activates cGMP-producing ability of guanylyl cyclase-D (GC-D), a membrane GC exclusively expressed in the CO(2)-responsive OSNs, by directly acting on the intracellular cyclase domain of GC-D.	co(2)	137-142	guanylate cyclase 2d	Mus musculus	87-91
19181845-4	2009	Here, we show that bicarbonate activates cGMP-producing ability of guanylyl cyclase-D (GC-D), a membrane GC exclusively expressed in the CO(2)-responsive OSNs, by directly acting on the intracellular cyclase domain of GC-D.	co(2)	137-142	guanylate cyclase 2d	Mus musculus	218-222
18618322-3	2009	Recombinant pure hCA III had the following kinetic parameters for the CO(2) hydration reaction at 20 degrees C and pH 7.5: k(cat) of 1.3 x 10(4) s(- 1) and k(cat)/K(M) of 2.5.10(5) M(- 1) s(- 1).	co(2)	70-75	carbonic anhydrase 3	Homo sapiens	17-24
19142892-8	2009	RESULTS: Exposure to 8% CO(2) resulted in an increased expression of alpha-smooth muscle actin (alpha-sma) which localized to the tips of developing alveolar buds, and also an increased number of alveolar buds at P7.	co(2)	24-29	actin alpha 2, smooth muscle, aorta	Mus musculus	69-94
19142892-8	2009	RESULTS: Exposure to 8% CO(2) resulted in an increased expression of alpha-smooth muscle actin (alpha-sma) which localized to the tips of developing alveolar buds, and also an increased number of alveolar buds at P7.	co(2)	24-29	actin alpha 2, smooth muscle, aorta	Mus musculus	96-105
19123845-8	2009	The calculated stabilization energies of the MTMS-CO(2), PME-CO(2), and 3-Hex-CO(2) dimers indicate that CO(2) interacts specifically with the three moieties through a Lewis acid-Lewis base type of interaction with the energies displaying the following order: E(MTMS-CO(2)) = -3.59 > E(PME-CO(2)) = -3.43 > E(3-Hex-CO(2)) = -2.5 kcal/mol.	co(2)	50-55	cystatin B	Homo sapiens	289-292
19123845-8	2009	The calculated stabilization energies of the MTMS-CO(2), PME-CO(2), and 3-Hex-CO(2) dimers indicate that CO(2) interacts specifically with the three moieties through a Lewis acid-Lewis base type of interaction with the energies displaying the following order: E(MTMS-CO(2)) = -3.59 > E(PME-CO(2)) = -3.43 > E(3-Hex-CO(2)) = -2.5 kcal/mol.	co(2)	50-55	hematopoietically expressed homeobox	Homo sapiens	317-320
19123845-8	2009	The calculated stabilization energies of the MTMS-CO(2), PME-CO(2), and 3-Hex-CO(2) dimers indicate that CO(2) interacts specifically with the three moieties through a Lewis acid-Lewis base type of interaction with the energies displaying the following order: E(MTMS-CO(2)) = -3.59 > E(PME-CO(2)) = -3.43 > E(3-Hex-CO(2)) = -2.5 kcal/mol.	co(2)	61-66	cystatin B	Homo sapiens	57-60
19123845-8	2009	The calculated stabilization energies of the MTMS-CO(2), PME-CO(2), and 3-Hex-CO(2) dimers indicate that CO(2) interacts specifically with the three moieties through a Lewis acid-Lewis base type of interaction with the energies displaying the following order: E(MTMS-CO(2)) = -3.59 > E(PME-CO(2)) = -3.43 > E(3-Hex-CO(2)) = -2.5 kcal/mol.	co(2)	61-66	cystatin B	Homo sapiens	57-60
19123845-8	2009	The calculated stabilization energies of the MTMS-CO(2), PME-CO(2), and 3-Hex-CO(2) dimers indicate that CO(2) interacts specifically with the three moieties through a Lewis acid-Lewis base type of interaction with the energies displaying the following order: E(MTMS-CO(2)) = -3.59 > E(PME-CO(2)) = -3.43 > E(3-Hex-CO(2)) = -2.5 kcal/mol.	co(2)	61-66	cystatin B	Homo sapiens	57-60
19536486-10	2009	In the CB, CO(2)/HCO(3) not only activated sAC but also regulated its expression, suggesting that sAC may be involved in the regulation of cAMP levels in response to hyper/hypocapnia.	co(2)	11-16	adenylate cyclase 10	Rattus norvegicus	43-46
19536486-10	2009	In the CB, CO(2)/HCO(3) not only activated sAC but also regulated its expression, suggesting that sAC may be involved in the regulation of cAMP levels in response to hyper/hypocapnia.	co(2)	11-16	adenylate cyclase 10	Rattus norvegicus	98-101
19536504-1	2009	Selective inhibition of the Na(+)/H(+) exchanger type 3 (NHE3) increases the firing rate of brainstem ventrolateral CO(2)/H(+) sensitive neurons, resembling the responses evoked by hypercapnic stimuli.	co(2)	116-121	solute carrier family 9 member A3	Rattus norvegicus	28-55
19536504-1	2009	Selective inhibition of the Na(+)/H(+) exchanger type 3 (NHE3) increases the firing rate of brainstem ventrolateral CO(2)/H(+) sensitive neurons, resembling the responses evoked by hypercapnic stimuli.	co(2)	116-121	solute carrier family 9 member A3	Rattus norvegicus	57-61
18842297-1	2009	The aim of this study was to investigate the effect of high pressure CO(2) on the crosslinking of elastin-based polymers and the characteristics of the fabricated hydrogels.	co(2)	69-74	elastin	Homo sapiens	98-105
18842297-2	2009	A hydrogel was fabricated by chemically crosslinking alpha-elastin with glutaraldehyde at high pressure CO(2).	co(2)	104-109	elastin	Homo sapiens	59-66
18842297-8	2009	The results of micro-CT scan and SEM images demonstrated that pore interconnectivity was substantially enhanced for alpha-elastin hydrogels fabricated using high pressure CO(2).	co(2)	171-176	elastin	Homo sapiens	122-129
18842297-9	2009	Dense gas CO(2) reduced the wall thickness and size of the pores and importantly induced channels within the structure of the alpha-elastin hydrogels.	co(2)	10-15	elastin	Homo sapiens	132-139
18983144-6	2008	The major UV-visible band of the examined compounds in their neutral Ru(2)(5+) form is located between 550 and 800 nm in CH(2)Cl(2) and also varies linearly with the number of CH(3)CO(2)(-) ligands on Ru(2)(CH(3)CO(2))(x)(Fap)(4-x)Cl.	co(2)	181-186	fibroblast activation protein alpha	Homo sapiens	222-225
19413687-1	2009	* Reductive catabolism of pyrimidine nucleotides occurs via a three-step pathway in which uracil is degraded to beta-alanine, CO(2) and NH(3) through sequential activities of dihydropyrimidine dehydrogenase (EC 1.3.1.2, PYD1), dihydropyrimidinase (EC 3.5.2.2, PYD2) and beta-ureidopropionase (EC 3.5.1.6, PYD3).	co(2)	126-131	pyrimidine 1	Arabidopsis thaliana	220-224
19413687-1	2009	* Reductive catabolism of pyrimidine nucleotides occurs via a three-step pathway in which uracil is degraded to beta-alanine, CO(2) and NH(3) through sequential activities of dihydropyrimidine dehydrogenase (EC 1.3.1.2, PYD1), dihydropyrimidinase (EC 3.5.2.2, PYD2) and beta-ureidopropionase (EC 3.5.1.6, PYD3).	co(2)	126-131	pyrimidine 2	Arabidopsis thaliana	260-264
19413687-1	2009	* Reductive catabolism of pyrimidine nucleotides occurs via a three-step pathway in which uracil is degraded to beta-alanine, CO(2) and NH(3) through sequential activities of dihydropyrimidine dehydrogenase (EC 1.3.1.2, PYD1), dihydropyrimidinase (EC 3.5.2.2, PYD2) and beta-ureidopropionase (EC 3.5.1.6, PYD3).	co(2)	126-131	beta-ureidopropionase	Arabidopsis thaliana	270-291
19413687-1	2009	* Reductive catabolism of pyrimidine nucleotides occurs via a three-step pathway in which uracil is degraded to beta-alanine, CO(2) and NH(3) through sequential activities of dihydropyrimidine dehydrogenase (EC 1.3.1.2, PYD1), dihydropyrimidinase (EC 3.5.2.2, PYD2) and beta-ureidopropionase (EC 3.5.1.6, PYD3).	co(2)	126-131	beta-ureidopropionase	Arabidopsis thaliana	305-309
18682519-9	2008	CONCLUSIONS: The response to CO(2) perfusion suggests that CO(2) diffuses through the stratum epithelium, interacting with TRPV1 and ASICs in the epithelium or in the submucosa.	co(2)	29-34	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	123-128
18682519-9	2008	CONCLUSIONS: The response to CO(2) perfusion suggests that CO(2) diffuses through the stratum epithelium, interacting with TRPV1 and ASICs in the epithelium or in the submucosa.	co(2)	59-64	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	123-128
18682519-10	2008	Inhibition of the hyperaemic response to luminal CO(2) by CA, TRPV1 and ASIC inhibitors implicates CA and these chemosensors in transduction of the luminal acid signal.	co(2)	49-54	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	62-67
18983144-5	2008	The E(1/2) values for the Ru(2)(5+/4+) and Ru(2)(5+/6+) processes vary linearly with the number of CH(3)CO(2)(-) bridging ligands on Ru(2)(CH(3)CO(2))(x)(Fap)(4-x)Cl and plots of reversible half-wave potentials vs the number of acetate groups follow linear free energy relationships with the largest substituent effect being observed for the oxidation.	co(2)	104-109	fibroblast activation protein alpha	Homo sapiens	154-157
18986129-7	2008	Average interaction energy between the anionic solute, I(2)(*-), and a solvent CO(2) molecule is approximately 129 meV in I(2)(*-) x nCO(2) clusters, and the average interaction energy between two solvent CO(2) molecules is approximately 85 meV in the case of neutral (CO(2))(n) clusters at MP2 level of theory.	co(2)	79-84	tryptase pseudogene 1	Homo sapiens	291-294
18988736-6	2008	It is proposed that, in both cases, a protonated basic residue (Arg-37 in the case of human UroD; Lys-93 in the case of yeast ODCase) furnishes a counterion that helps the scissile carboxylate group of the substrate leave water and enter a relatively nonpolar environment, stabilizes the incipient carbanion generated by the departure of CO(2), and supplies the proton that takes its place.	co(2)	338-343	uroporphyrinogen decarboxylase	Homo sapiens	92-96
19036978-6	2008	We found that most pFRG/Pre-I neurons were Phox2b immunoreactive and depolarized upon increase in CO(2) concentration under condition of action potential-dependent synaptic transmission blockade by tetrodotoxin.	co(2)	98-103	paired-like homeobox 2b	Rattus norvegicus	43-49
18799484-3	2008	In low-light-grown pgr5, the CO(2) assimilation rate and ETR were similar to the those of the wild type at low irradiance, but decreased at saturating irradiance under photorespiratory conditions as well as non-photorespiratory conditions.	co(2)	29-34	proton gradient regulation 5	Arabidopsis thaliana	19-23
18667600-7	2008	These findings suggest that V-ATPase may be involved in proton secretion in the OE and, as such, may be important for the pH homeostasis of the neuroepithelial mucous layer and/or for signal transduction in CO(2) detection.	co(2)	207-212	ATPase, H+ transporting, lysosomal V0 subunit D2	Mus musculus	28-36
18833277-7	2008	Therefore, the growth of ice sheets in the Northern Hemisphere immediately following Antarctic glaciation would have required rapid CO(2) drawdown within the Oi-1 timeframe, to levels lower than those estimated by geochemical proxies and carbon-cycle models.	co(2)	132-137	collagen type I alpha 1 chain	Homo sapiens	158-162
18678907-6	2008	Experimental results and molecular dynamics simulations reveal highly oriented CO(2) distributions that preferentially scatter with "top spin" as a strongly increasing function of J state.	co(2)	79-84	spindlin 1	Homo sapiens	137-142
18478583-10	2008	We find exceptionally high values of MAE, close to 0.2 eV, for four particular dimers: Fe(2), Co(2), Ni(2), and Rh(2).	co(2)	94-99	solute carrier family 6 member 1	Homo sapiens	37-40
18482982-1	2008	CA9 is a membrane-tethered, carbonic anhydrase (CA) enzyme, expressed mainly at the external surface of cells, that catalyzes reversible CO(2) hydration.	co(2)	137-142	carbonic anhydrase 9	Homo sapiens	0-3
18599644-5	2008	Germinated seeds of sdp6 were severely impaired in the metabolism of [U-(14)C]glycerol to CO(2) and accumulated high levels of G3P.	co(2)	90-95	FAD-dependent oxidoreductase family protein	Arabidopsis thaliana	20-24
18579160-0	2008	Regional scale impacts of distinct CO(2) additions in the North Sea.	co(2)	35-40	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	64-67
18728242-3	2008	CYP2D6 phenotype was determined by (13)CO(2) enrichment measured by infrared spectrometry (delta-over-baseline [DOB] value) in expired breath samples collected before and up to 240 minutes after [(13)C]-DM ingestion and by 4-hour urinary metabolite ratio.	co(2)	39-44	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	0-6
18719333-7	2008	In HCO(3)(-)/CO(2)-buffered solution, the steady-state pHi was 7.17 +/- 0.01 (n = 19).	co(2)	13-18	glucose-6-phosphate isomerase 1	Mus musculus	55-58
18482982-10	2008	Diffusion-reaction modeling indicates that CA9 coordinates pH(i) spatially by facilitating CO(2) diffusion in the unstirred extracellular space of the spheroid.	co(2)	91-96	carbonic anhydrase 9	Homo sapiens	43-46
18319254-10	2008	Moreover we found that that the (36)Cl efflux from NCBE-expressing oocytes, interpreted by others to be coupled to the influx of Na(+) and HCO(3)(-), actually represents a CO(2)/HCO(3)(-)-stimulated Cl(-) self-exchange not coupled to either Na(+) or net HCO(3)(-) transport.	co(2)	172-177	solute carrier family 4 member 10	Homo sapiens	51-55
18371179-7	2008	Primary cultured microglial cells subjected to hypoxia (3% oxygen, 5% CO(2) and 92% nitrogen) showed enhanced expression of TNF-alpha and IL-1beta.	co(2)	70-75	tumor necrosis factor	Rattus norvegicus	124-133
18371179-7	2008	Primary cultured microglial cells subjected to hypoxia (3% oxygen, 5% CO(2) and 92% nitrogen) showed enhanced expression of TNF-alpha and IL-1beta.	co(2)	70-75	interleukin 1 beta	Rattus norvegicus	138-146
18503368-4	2008	The aim of this study was to evaluate the effects of different pressures of CO(2) on apoptosis and p53 expression in small and large intestines and the stomach.	co(2)	76-81	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	99-102
18430561-3	2008	POX catalyzes the degradation of pyruvate to acetylphosphate, CO(2) and H(2)O(2) in the presence of phosphate and oxygen.	co(2)	62-67	proline dehydrogenase 1	Homo sapiens	0-3
18563235-4	2008	Quantitative DEMS measurements indicate that only CO(2) was detected as a final product during formic acid oxidation on Pt, PtPb and PtBi electrodes.	co(2)	50-55	protein tyrosine phosphatase receptor type B	Homo sapiens	124-128
18563235-6	2008	In contrast, CO(2) is the major product for formaldehyde and methanol oxidation at a PtPb electrode.	co(2)	13-18	protein tyrosine phosphatase receptor type B	Homo sapiens	85-89
18563235-7	2008	The high current efficiency of CO(2) formation for methanol and formaldehyde oxidation at a PtPb electrode can be ascribed to the complete dehydrogenation of formaldehyde and formic acid due to electronic effects.	co(2)	31-36	protein tyrosine phosphatase receptor type B	Homo sapiens	92-96
18563235-8	2008	The low onset potential, high current density and high CO(2) yield make PtPb one of the most promising electrocatalysts for fuel cell applications using small organic molecules as fuels.	co(2)	55-60	protein tyrosine phosphatase receptor type B	Homo sapiens	72-76
18486376-3	2008	Moreover, FBD-CO(2) (0.1-10 microg/ml) inhibited 0.1 microM phorbol myristate acetate-evoked oxidative burst in rat PMNs, 20 ng/ml TNF-alpha-triggered PMNs adhesion to ECV304 endothelial cells, and PMNs neurotoxicity to PC12 neuron-like cells as well as NSE release (IC(50) 1.30, 0.98, 0.24 and 0.82 microg/ml, respectively).	co(2)	14-19	tumor necrosis factor	Rattus norvegicus	131-140
18486376-3	2008	Moreover, FBD-CO(2) (0.1-10 microg/ml) inhibited 0.1 microM phorbol myristate acetate-evoked oxidative burst in rat PMNs, 20 ng/ml TNF-alpha-triggered PMNs adhesion to ECV304 endothelial cells, and PMNs neurotoxicity to PC12 neuron-like cells as well as NSE release (IC(50) 1.30, 0.98, 0.24 and 0.82 microg/ml, respectively).	co(2)	14-19	enolase 2	Rattus norvegicus	254-257
18486376-4	2008	Our study demonstrated that FBD-CO(2) prevented brain ischemia/reperfusion injury, at least in part, by limiting PMNs infiltration and neurotoxicity mediated by TNF-alpha, IL-1beta and IL-8, via inhibition on NF-kappaB activation.	co(2)	32-37	tumor necrosis factor	Rattus norvegicus	161-170
18486376-4	2008	Our study demonstrated that FBD-CO(2) prevented brain ischemia/reperfusion injury, at least in part, by limiting PMNs infiltration and neurotoxicity mediated by TNF-alpha, IL-1beta and IL-8, via inhibition on NF-kappaB activation.	co(2)	32-37	interleukin 1 beta	Rattus norvegicus	172-180
18353640-5	2008	CA XIII might catalyze other physiological reactions than CO(2) hydration, based on its relevant phosphatase activity.	co(2)	58-63	carbonic anhydrase 13	Homo sapiens	0-7
18070822-5	2008	In contrast, P0 AMCs from pups born to nicotine-treated dams showed a marked suppression or loss of hypoxic sensitivity, although hypercapnic sensitivity and the expression of CO(2) markers (i.e., carbonic anhydrase I and II) appeared normal.	co(2)	176-181	carbonic anhydrase 1	Rattus norvegicus	197-224
18366225-5	2008	The air bubbles are stable for more than 4 days, whereas the CO(2) bubbles are only stable for 1-2 h. We determine the average gas pressure inside the CO(2) bubbles from the IR spectrum in two ways: from the width of the rotational fine structure (P(gas) < 2 atm) and from the intensity in the IR spectrum (P(gas) = 1.1 +/- 0.4 atm).	co(2)	151-156	ATM serine/threonine kinase	Homo sapiens	262-265
18366225-5	2008	The air bubbles are stable for more than 4 days, whereas the CO(2) bubbles are only stable for 1-2 h. We determine the average gas pressure inside the CO(2) bubbles from the IR spectrum in two ways: from the width of the rotational fine structure (P(gas) < 2 atm) and from the intensity in the IR spectrum (P(gas) = 1.1 +/- 0.4 atm).	co(2)	151-156	ATM serine/threonine kinase	Homo sapiens	331-334
18305209-4	2008	A combination of sugar, sugar analogs, light, and CO(2) treatments provided evidence that these genes are not regulated by a common mechanism and unraveled at least four different signaling pathways involved: regulation by light per se, by HXK-dependent sugar sensing, and by sugar sensing upstream or downstream HXK, respectively.	co(2)	50-55	hexokinase 1	Homo sapiens	240-243
18335029-3	2008	We wondered whether insulin-operated signaling pathways modulate mitochondrial respiration via NO, to alternatively release complete glucose oxidation to CO(2) and H(2)O or to drive glucose storage to glycogen.	co(2)	154-159	insulin	Homo sapiens	20-27
18343915-6	2008	In a CO(2) hydration assay, 3 behaved as a very weak, partial inhibitor of CA-II and CA-I.	co(2)	5-10	carbonic anhydrase 2	Homo sapiens	75-80
18343915-6	2008	In a CO(2) hydration assay, 3 behaved as a very weak, partial inhibitor of CA-II and CA-I.	co(2)	5-10	carbonic anhydrase 1	Homo sapiens	75-79
18305209-4	2008	A combination of sugar, sugar analogs, light, and CO(2) treatments provided evidence that these genes are not regulated by a common mechanism and unraveled at least four different signaling pathways involved: regulation by light per se, by HXK-dependent sugar sensing, and by sugar sensing upstream or downstream HXK, respectively.	co(2)	50-55	hexokinase 1	Homo sapiens	313-316
18326729-2	2008	The authors examined the role of carbonic anhydrase IV (CAIV) in facilitating CO(2) flux, HCO(3)(-) permeability, and HCO(3)(-) flux across the apical membrane.	co(2)	78-83	carbonic anhydrase 4	Bos taurus	33-54
18326729-2	2008	The authors examined the role of carbonic anhydrase IV (CAIV) in facilitating CO(2) flux, HCO(3)(-) permeability, and HCO(3)(-) flux across the apical membrane.	co(2)	78-83	carbonic anhydrase 4	Bos taurus	56-60
18326729-9	2008	Both 10 microM benzolamide and CAIV siRNA reduced apparent apical CO(2) flux by approximately 20%; however, they had no effect on HCO(3)(-) permeability or HCO(3)(-) flux.	co(2)	66-71	carbonic anhydrase 4	Bos taurus	31-35
18302920-1	2008	Determination of the historical causes of organismal adaptations is difficult, but a recent study has suggested that at least one of the transitions to C(4) photosynthesis was directly facilitated by changes in atmospheric CO(2) levels.	co(2)	223-228	complement C4A (Rodgers blood group)	Homo sapiens	152-156
18441386-4	2008	Irrespective of the substance, NHE3 inhibition reduced G by 33.0 +/- 7.8% (n = 10, P<0.01) at 35.5 +/- 1.6 mmHg PaCO(2) (mean +/-SE), but not at lower arterial CO(2) levels (n=5).	co(2)	117-122	solute carrier family 9 member A3	Homo sapiens	31-35
18184736-11	2008	Thus, a putative metabolon involving PEPC and PDC(pl) could function to channel carbon from phosphoenolpyruvate to acetyl-coenzyme A and/or to recycle CO(2) from PDC(pl) to PEPC.	co(2)	151-156	LOC8259391	Ricinus communis	37-41
18184736-11	2008	Thus, a putative metabolon involving PEPC and PDC(pl) could function to channel carbon from phosphoenolpyruvate to acetyl-coenzyme A and/or to recycle CO(2) from PDC(pl) to PEPC.	co(2)	151-156	LOC8259391	Ricinus communis	173-177
18349152-5	2008	RNA interference-mediated decreases in Nt AQP1 expression lowered the CO(2) permeability of the inner chloroplast membrane.	co(2)	70-75	probable aquaporin TIP1-1	Nicotiana tabacum	42-46
18349152-6	2008	In vivo data show that the reduced amount of Nt AQP1 caused a 20% change in CO(2) conductance within leaves.	co(2)	76-81	probable aquaporin TIP1-1	Nicotiana tabacum	48-52
18349152-7	2008	Our discovery of CO(2) aquaporin function in the chloroplast membrane opens new opportunities for mechanistic examination of leaf internal CO(2) conductance regulation.	co(2)	17-22	aquaporin PIP2-7-like	Nicotiana tabacum	23-32
18349152-7	2008	Our discovery of CO(2) aquaporin function in the chloroplast membrane opens new opportunities for mechanistic examination of leaf internal CO(2) conductance regulation.	co(2)	139-144	aquaporin PIP2-7-like	Nicotiana tabacum	23-32
18188452-4	2008	Activation of AMPK was mediated by a CO(2)-triggered increase in intracellular Ca(2+) concentration and Ca(2+)/calmodulin-dependent kinase kinase-beta (CaMKK-beta).	co(2)	37-42	calcium/calmodulin-dependent protein kinase kinase 2	Rattus norvegicus	152-162
18077606-10	2008	Furthermore, disruption of the NBCn1 gene resulted in a lower intracellular steady-state pH of bladder smooth muscle cells in the presence of CO(2)/HCO(3)(-) but not in its nominal absence.	co(2)	142-147	solute carrier family 4, sodium bicarbonate cotransporter, member 7	Mus musculus	31-36
21632342-5	2008	Thermotolerance of P(n) in elevated (vs. ambient) CO(2) increased in C(3), but decreased in C(4) (especially) and CAM (high growth temperature only), species.	co(2)	50-55	complement C3	Homo sapiens	69-73
18188452-5	2008	Chelating intracellular Ca(2+) or abrogating CaMKK-beta function by gene silencing or chemical inhibition prevented the CO(2)-induced AMPK activation in AECs.	co(2)	120-125	calcium/calmodulin-dependent protein kinase kinase 2	Rattus norvegicus	45-55
18202004-2	2008	In a unicellular green alga, Chlamydomonas reinhardtii, a regulatory factor CCM1 is indispensable for the regulation of the CCM by sensing CO(2) availability.	co(2)	139-144	uncharacterized protein	Chlamydomonas reinhardtii	76-80
18065555-3	2008	In the anti-b/f plants, CO(2) assimilation rates were proportional to leaf cytochrome b(6)f content, but there was little effect on stomatal conductance and the rate of stomatal opening.	co(2)	24-29	mitochondrially encoded cytochrome b	Homo sapiens	75-87
18336307-5	2008	These two CAs are catalytically efficient with almost identical activity to that of the human isoform CA I for the CO(2) hydration reaction, and highly inhibited by many sulfonamides/sulfamates, including acetazolamide, ethoxzolamide, topiramate and sulpiride, all clinically used drugs.	co(2)	115-120	carbonic anhydrase 1	Homo sapiens	102-106
18202181-2	2008	We studied the selectivity of aquaporin-1 (AQP1) and the bacterial glycerol facilitator, GlpF, for O(2), CO(2), NH(3), glycerol, urea, and water.	co(2)	105-110	aquaporin 1 (Colton blood group)	Homo sapiens	30-41
18202181-2	2008	We studied the selectivity of aquaporin-1 (AQP1) and the bacterial glycerol facilitator, GlpF, for O(2), CO(2), NH(3), glycerol, urea, and water.	co(2)	105-110	aquaporin 1 (Colton blood group)	Homo sapiens	43-47
18769029-9	2008	However, the presence of HCO(3)(-)/CO(2) stimulates the Cl(-)-transporting activity of SLC26A9 in Xenopus laevis oocytes or SLC26A9-transduced COS-7 cells.	co(2)	35-40	solute carrier family 26 member 9	Homo sapiens	87-94
18769029-9	2008	However, the presence of HCO(3)(-)/CO(2) stimulates the Cl(-)-transporting activity of SLC26A9 in Xenopus laevis oocytes or SLC26A9-transduced COS-7 cells.	co(2)	35-40	solute carrier family 26 member 9	Homo sapiens	124-131
18315697-7	2008	In addition, it is shown that delayed flowering at elevated [CO(2)] is associated with sustained expression of the floral repressor gene, FLOWERING LOCUS C (FLC), in an elevated CO(2)-adapted genotype.	co(2)	61-66	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	138-155
18316317-3	2008	The reduction in CO(2) assimilation in PEPC overproduction lines remained unaffected by overproduction of PPDK, ME or a combination of both, however it was significantly restored by the combined overproduction of PPDK, ME, and MDH to reach levels comparable to or slightly higher than that of non-transgenic rice.	co(2)	17-22	MLO-like protein 4	Zea mays	39-43
18316317-3	2008	The reduction in CO(2) assimilation in PEPC overproduction lines remained unaffected by overproduction of PPDK, ME or a combination of both, however it was significantly restored by the combined overproduction of PPDK, ME, and MDH to reach levels comparable to or slightly higher than that of non-transgenic rice.	co(2)	17-22	pyruvate, phosphate dikinase 1, chloroplastic	Zea mays	213-217
18028298-5	2008	Some respired CO(2) remaining in the stem dissolves in xylem sap and is transported toward the leaves.	co(2)	14-19	SH2 domain containing 1A	Homo sapiens	61-64
18315697-7	2008	In addition, it is shown that delayed flowering at elevated [CO(2)] is associated with sustained expression of the floral repressor gene, FLOWERING LOCUS C (FLC), in an elevated CO(2)-adapted genotype.	co(2)	61-66	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	157-160
18315697-7	2008	In addition, it is shown that delayed flowering at elevated [CO(2)] is associated with sustained expression of the floral repressor gene, FLOWERING LOCUS C (FLC), in an elevated CO(2)-adapted genotype.	co(2)	178-183	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	138-155
18315697-7	2008	In addition, it is shown that delayed flowering at elevated [CO(2)] is associated with sustained expression of the floral repressor gene, FLOWERING LOCUS C (FLC), in an elevated CO(2)-adapted genotype.	co(2)	178-183	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	157-160
17890067-3	2007	It was shown that the viability of Caco-2 cells was enhanced by use of the CO(2) independent nutritional medium, Leibovitz"s L-15 compared to Hanks" balanced salt solution.	co(2)	75-80	immunoglobulin kappa variable 1D-16	Homo sapiens	125-129
17627102-12	2008	COPD patients though decreased their resting CO(2) by increased minute ventilation.	co(2)	45-50	COPD	Homo sapiens	0-4
17559083-1	2008	The heteromeric Kir4.1-Kir5.1 channel is a candidate sensing molecule for central CO(2) chemoreception.	co(2)	82-87	potassium inwardly rectifying channel subfamily J member 10 S homeolog	Xenopus laevis	16-22
17559083-1	2008	The heteromeric Kir4.1-Kir5.1 channel is a candidate sensing molecule for central CO(2) chemoreception.	co(2)	82-87	potassium inwardly rectifying channel subfamily J member 16 S homeolog	Xenopus laevis	23-29
17559083-2	2008	Since central CO(2) chemoreception is subject to neural modulations, we performed studies to test the hypothesis that the Kir4.1-Kir5.1 channel is modulated by the neurotransmitters critical for respiratory control, including serotonin (5-HT), substance-P (SP), and thyrotropin releasing hormone (TRH).	co(2)	14-19	potassium inwardly rectifying channel subfamily J member 10 S homeolog	Xenopus laevis	122-128
17559083-2	2008	Since central CO(2) chemoreception is subject to neural modulations, we performed studies to test the hypothesis that the Kir4.1-Kir5.1 channel is modulated by the neurotransmitters critical for respiratory control, including serotonin (5-HT), substance-P (SP), and thyrotropin releasing hormone (TRH).	co(2)	14-19	potassium inwardly rectifying channel subfamily J member 16 S homeolog	Xenopus laevis	129-135
17559083-7	2008	The firing rate of CO(2)-sensitive brainstem neurons cultured in microelectrode arrays was augmented by SP or a 5-HT2A receptor agonist, which was blocked by PKC inhibitors suggesting that PKC underscores the inhibitory effect of SP and 5-HT in cultured brainstem neurons as well.	co(2)	19-24	tachykinin precursor 1 L homeolog	Xenopus laevis	104-106
17559083-7	2008	The firing rate of CO(2)-sensitive brainstem neurons cultured in microelectrode arrays was augmented by SP or a 5-HT2A receptor agonist, which was blocked by PKC inhibitors suggesting that PKC underscores the inhibitory effect of SP and 5-HT in cultured brainstem neurons as well.	co(2)	19-24	tachykinin precursor 1 L homeolog	Xenopus laevis	230-232
17884809-2	2007	Our previous studies on structural organization and enzymatic properties of rat FDH suggest that the overall enzyme reaction, i.e. NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO(2), consists of two steps: (i) hydrolytic cleavage of the formyl group in the N-terminal catalytic domain, followed by (ii) NADP(+)-dependent oxidation of the formyl group to CO(2) in the C-terminal aldehyde dehydrogenase domain.	co(2)	213-218	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	80-83
17826101-2	2007	Recombinant pure hCA III had the following kinetic parameters for the CO(2) hydration reaction at 20 degrees C and pH 7.5: k(cat) of 1.3 x 10(4) s(-1) and k(cat)/K(M) of 2.5 x 10(5) M(-1) s(-1), being a slower catalyst for the physiological reaction as compared to the genetically related cytosolic isoforms hCA I and II.	co(2)	70-75	carbonic anhydrase 3	Homo sapiens	17-24
17826101-2	2007	Recombinant pure hCA III had the following kinetic parameters for the CO(2) hydration reaction at 20 degrees C and pH 7.5: k(cat) of 1.3 x 10(4) s(-1) and k(cat)/K(M) of 2.5 x 10(5) M(-1) s(-1), being a slower catalyst for the physiological reaction as compared to the genetically related cytosolic isoforms hCA I and II.	co(2)	70-75	carbonic anhydrase 1	Homo sapiens	308-320
17076937-7	2007	Cortisol and ACTH levels increased in the patient and control groups following 35% CO(2) inhalation.	co(2)	83-88	proopiomelanocortin	Homo sapiens	13-17
17884809-2	2007	Our previous studies on structural organization and enzymatic properties of rat FDH suggest that the overall enzyme reaction, i.e. NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO(2), consists of two steps: (i) hydrolytic cleavage of the formyl group in the N-terminal catalytic domain, followed by (ii) NADP(+)-dependent oxidation of the formyl group to CO(2) in the C-terminal aldehyde dehydrogenase domain.	co(2)	391-396	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	80-83
17715184-5	2007	A weak response to CO(2) at thermoneutrality (32 degrees C) was noted previously in 2-day-old mice with an invalidated Phox2b allele (Phox2b+/-), compared with wild-type littermates.	co(2)	19-24	paired-like homeobox 2b	Mus musculus	119-125
17715184-5	2007	A weak response to CO(2) at thermoneutrality (32 degrees C) was noted previously in 2-day-old mice with an invalidated Phox2b allele (Phox2b+/-), compared with wild-type littermates.	co(2)	19-24	paired-like homeobox 2b	Mus musculus	134-140
17142037-9	2007	In situ measurement of CO(2) and CH(4) emissions from the gravel of the SSF ranged from 0.106 to 0.464 and from 0.039 to 0.107 mmol/m(2)h, respectively.	co(2)	23-28	peter pan homolog	Homo sapiens	72-75
17720771-1	2007	We reported previously that intermittent hypoxia with CO(2) to maintain eucapnia (IH-C) elevates plasma endothelin-1 (ET-1) and arterial pressure.	co(2)	54-59	endothelin 1	Rattus norvegicus	104-116
17720771-1	2007	We reported previously that intermittent hypoxia with CO(2) to maintain eucapnia (IH-C) elevates plasma endothelin-1 (ET-1) and arterial pressure.	co(2)	54-59	endothelin 1	Rattus norvegicus	118-122
18000780-7	2007	Positive expression of HIF-1alpha and VEGF in CO(2) and He artificial pneumoperitoneum up-regulated significantly as compared to control group(P<0.01), meanwhile the above expression was higher in CO(2) group (P<0.01).	co(2)	46-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-33
17919181-3	2007	Pancreatic beta-cells may be extremely sensitive to the accumulation of mtDNA mutations, as insulin secretion requires the mitochondrial oxidation of glucose to CO(2).	co(2)	161-166	insulin	Homo sapiens	92-99
17717124-9	2007	Supplementation of orexin-A or -B (3 nmol) partially restored the hypercapnic chemoreflex in ORX-KO mice (0.28 +/- 0.03 mlxmin(-1).g(-1)x% CO(2)(-1) for orexin-A and 0.32 +/- 0.04 mlxmin(-1)xg(-1)x% CO(2)(-1) for orexin-B).	co(2)	139-144	hypocretin	Mus musculus	19-33
17717124-9	2007	Supplementation of orexin-A or -B (3 nmol) partially restored the hypercapnic chemoreflex in ORX-KO mice (0.28 +/- 0.03 mlxmin(-1).g(-1)x% CO(2)(-1) for orexin-A and 0.32 +/- 0.04 mlxmin(-1)xg(-1)x% CO(2)(-1) for orexin-B).	co(2)	199-204	hypocretin	Mus musculus	19-33
17717124-12	2007	Our findings suggest that orexin plays a crucial role in CO(2) sensitivity at least during wake periods in mice.	co(2)	57-62	hypocretin	Mus musculus	26-32
17877712-3	2007	These effects were absent when cat2 was grown at high CO(2) levels to inhibit photorespiration, but were re-established following a subsequent transfer to air.	co(2)	54-59	catalase 2	Arabidopsis thaliana	31-35
18000780-7	2007	Positive expression of HIF-1alpha and VEGF in CO(2) and He artificial pneumoperitoneum up-regulated significantly as compared to control group(P<0.01), meanwhile the above expression was higher in CO(2) group (P<0.01).	co(2)	46-51	vascular endothelial growth factor A	Homo sapiens	38-42
18000780-7	2007	Positive expression of HIF-1alpha and VEGF in CO(2) and He artificial pneumoperitoneum up-regulated significantly as compared to control group(P<0.01), meanwhile the above expression was higher in CO(2) group (P<0.01).	co(2)	200-205	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-33
18000780-7	2007	Positive expression of HIF-1alpha and VEGF in CO(2) and He artificial pneumoperitoneum up-regulated significantly as compared to control group(P<0.01), meanwhile the above expression was higher in CO(2) group (P<0.01).	co(2)	200-205	vascular endothelial growth factor A	Homo sapiens	38-42
17803955-5	2007	However, cyclic flow is affected by the pgr5 mutation under conditions where this process is normally enhanced in wild type leaves, i.e. high light or low CO(2) concentrations resulted in enhancement of cyclic electron flow.	co(2)	155-160	proton gradient regulation 5	Arabidopsis thaliana	40-44
17673462-3	2007	We hypothesized that, besides its role as a water channel, aquaporin-1 (AQP-1) could also work as an O(2) transporter, because this transmembrane protein appears to be CO(2)-permeable and is highly expressed in cells with rapid O(2) turnover (erythrocytes and microvessel endothelium).	co(2)	168-173	aquaporin 1 (Colton blood group)	Homo sapiens	59-70
17673462-3	2007	We hypothesized that, besides its role as a water channel, aquaporin-1 (AQP-1) could also work as an O(2) transporter, because this transmembrane protein appears to be CO(2)-permeable and is highly expressed in cells with rapid O(2) turnover (erythrocytes and microvessel endothelium).	co(2)	168-173	aquaporin 1 (Colton blood group)	Homo sapiens	72-77
17660359-8	2007	Homologues of FEA1 and FRE1 were identified previously as high-CO(2)-responsive genes, HCR1 and HCR2, in Chlorococcum littorale, suggesting that components of the iron assimilation pathway are responsive to carbon nutrition.	co(2)	63-68	uncharacterized protein	Chlamydomonas reinhardtii	14-18
17660359-8	2007	Homologues of FEA1 and FRE1 were identified previously as high-CO(2)-responsive genes, HCR1 and HCR2, in Chlorococcum littorale, suggesting that components of the iron assimilation pathway are responsive to carbon nutrition.	co(2)	63-68	uncharacterized protein	Chlamydomonas reinhardtii	23-27
17573537-5	2007	The pifi mutant exhibited a lower capacity for nonphotochemical quenching, but similar CO(2) assimilation rates, photosystem II (PSII) quantum efficiencies (PhiPSII), and reduction levels of the primary electron acceptor of PSII (1 - qL) as compared with the wild type.	co(2)	87-92	post-illumination chlorophyll fluorescence increase	Arabidopsis thaliana	4-8
17600278-2	2007	Selective NHE3 inhibitors can evoke CO(2) mimetic responses both in vitro and in vivo, demonstrating the functional significance of this pH-regulating protein.	co(2)	36-41	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	10-14
18251921-1	2007	In cyanobacteria, the NAD(P)H:quinone oxidoreductase (NDH-1) is involved in a variety of functions like respiration, cyclic electron flow around PSI and CO(2) uptake.	co(2)	153-158	crystallin zeta	Homo sapiens	30-52
17664347-9	2007	The reduction of the membrane conductance by CAII was dependent on the presence of CO(2)/HCO(3)(-), and could be reversed by blocking the catalytic activity of CAII by ethoxyzolamide (10 microM).	co(2)	83-88	carbonic anhydrase 2 S homeolog	Xenopus laevis	45-49
17585871-2	2007	The heteromeric Kir4.1-Kir5.1 channel is expressed in the eye, kidney and brainstem and has CO(2)/pH sensitivity in the physiological range, suggesting a candidate molecule for the regulation of K(+) homeostasis and central CO(2) chemoreception.	co(2)	92-97	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	16-22
17585871-2	2007	The heteromeric Kir4.1-Kir5.1 channel is expressed in the eye, kidney and brainstem and has CO(2)/pH sensitivity in the physiological range, suggesting a candidate molecule for the regulation of K(+) homeostasis and central CO(2) chemoreception.	co(2)	92-97	potassium inwardly rectifying channel subfamily J member 16	Homo sapiens	23-29
17585871-2	2007	The heteromeric Kir4.1-Kir5.1 channel is expressed in the eye, kidney and brainstem and has CO(2)/pH sensitivity in the physiological range, suggesting a candidate molecule for the regulation of K(+) homeostasis and central CO(2) chemoreception.	co(2)	224-229	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	16-22
17585871-2	2007	The heteromeric Kir4.1-Kir5.1 channel is expressed in the eye, kidney and brainstem and has CO(2)/pH sensitivity in the physiological range, suggesting a candidate molecule for the regulation of K(+) homeostasis and central CO(2) chemoreception.	co(2)	224-229	potassium inwardly rectifying channel subfamily J member 16	Homo sapiens	23-29
17723887-1	2007	BACKGROUND: We have shown previously that abdominal insufflation with CO(2) increases serum levels of IL-10 and TNFalpha and increases survival among animals with lipopolysaccharide (LPS)-induced sepsis, even after a laparotomy.	co(2)	70-75	interleukin 10	Rattus norvegicus	102-107
17723887-1	2007	BACKGROUND: We have shown previously that abdominal insufflation with CO(2) increases serum levels of IL-10 and TNFalpha and increases survival among animals with lipopolysaccharide (LPS)-induced sepsis, even after a laparotomy.	co(2)	70-75	tumor necrosis factor	Rattus norvegicus	112-120
17499996-2	2007	The kinetic parameters for the CO(2) hydration reaction proved hCA VI to possess a k(cat) of 3.4 x 10(5)s(-1) and k(cat)/K(M) of 4.9 x 10(7)M(-1)s(-1) (at pH 7.5 and 20 degrees C).	co(2)	31-36	HCA1	Homo sapiens	63-66
17408985-11	2007	CONCLUSIONS: The data suggest JNK, rather than p38 or ERK dependent increases in PG synthesis, and selective, partially integrin-dependent, activation of JNK kinases in human chondrocyte cell lines following cyclical MS. JNK activation is also very sensitive to changes in CO(2)/pH in this chondrocyte culture model.	co(2)	273-278	mitogen-activated protein kinase 8	Homo sapiens	154-157
17408985-11	2007	CONCLUSIONS: The data suggest JNK, rather than p38 or ERK dependent increases in PG synthesis, and selective, partially integrin-dependent, activation of JNK kinases in human chondrocyte cell lines following cyclical MS. JNK activation is also very sensitive to changes in CO(2)/pH in this chondrocyte culture model.	co(2)	273-278	mitogen-activated protein kinase 8	Homo sapiens	154-157
17803382-0	2007	The effect of CO(2) laser irradiation on oral soft tissue problems in children in Sri Lanka.	co(2)	14-19	sorcin	Homo sapiens	82-85
17803382-1	2007	OBJECTIVE: This study was conducted to investigate the effects of CO(2) laser irradiation on oral tissue problems in pediatric cases in Sri Lanka.	co(2)	66-71	sorcin	Homo sapiens	136-139
17557075-4	2007	We report two dominant mutations in the OPEN STOMATA2 (OST2) locus of Arabidopsis that completely abolish stomatal response to ABA, but importantly, to a much lesser extent the responses to CO(2) and darkness.	co(2)	190-195	H[+]-ATPase 1	Arabidopsis thaliana	40-53
17557075-4	2007	We report two dominant mutations in the OPEN STOMATA2 (OST2) locus of Arabidopsis that completely abolish stomatal response to ABA, but importantly, to a much lesser extent the responses to CO(2) and darkness.	co(2)	190-195	H[+]-ATPase 1	Arabidopsis thaliana	55-59
17567269-8	2007	SIN-1 in addition to fluid resuscitation significantly improved the ileal-arterial P(CO(2)), whereas fluid alone failed to decrease the P(CO(2)) gap.	co(2)	85-90	MAPK associated protein 1	Homo sapiens	0-5
17465975-7	2007	In all groups, the peak inspiratory pressure and P(a)(CO(2)) increased progressively during PPN in TLP.	co(2)	54-59	cysteine rich protein 3	Homo sapiens	99-102
17465975-8	2007	P((a-ET))(CO(2)) increased gradually after starting CO(2) insufflation in TLP only in the elderly group.	co(2)	10-15	cysteine rich protein 3	Homo sapiens	74-77
17550442-7	2007	RESULTS: Both CO(2) and Er:YAG lasers were found to induce a significant decrease in p53 expression in biopsies obtained after 3 months (p=.0004 and .002, respectively) followed by gradual increase (p=.01 in both groups).	co(2)	14-19	tumor protein p53	Homo sapiens	85-88
17581222-5	2007	The half [(13)CO(2)] excretion time (T1/2b) is closely correlated with the scintigraphic half-emptying time (T1/2s).	co(2)	14-19	interleukin 1 receptor like 1	Homo sapiens	37-42
17415526-5	2007	Expression of the enzyme carbonic anhydrase 9 on the tumor cell surface catalyses the extracellular trapping of acid by hydrating cell-generated CO(2) into [see text] and H(+).	co(2)	145-150	carbonic anhydrase 9	Homo sapiens	25-45
17356125-9	2007	Knocking out AT(1A) modestly lowers baseline J(HCO(3)) and, like luminal saralasin or candesartan in rabbits, eliminates the J(HCO(3)) response to changes in [CO(2)](BL).	co(2)	159-164	angiotensin II receptor, type 1a	Mus musculus	13-18
17356125-10	2007	Our accumulated evidence suggests that ANG II endogenous to the PT binds to the apical AT(1A) receptor and that this interaction is critical for both baseline J(HCO(3)) and its response to changes in [CO(2)](BL).	co(2)	201-206	angiotensin II receptor, type 1a	Mus musculus	87-92
17339414-14	2007	Insulin did not increase conversion of glucose to CO(2), lactate, or total lipid in steers fed hay but caused an increase (per cell) of 97 to 110% in glucose conversion to CO(2), 46 to 54% in glucose conversion to lactate, and 65 to 160% in glucose conversion to total lipid content in adipose tissue from steers fed corn.	co(2)	172-177	insulin	Homo sapiens	0-7
17591988-3	2007	Real time estimations of [cAMP] changes in ciliated cells, using FRET between fluorescently tagged PKA subunits (expressed under the foxj1 promoter solely in ciliated cells), revealed CO(2)/HCO(3)(-)-mediated cAMP production.	co(2)	184-189	forkhead box J1	Homo sapiens	133-138
17550442-10	2007	CONCLUSION: The decrease in epidermal p53 expression after CO(2) and Er:YAG lasers may account for some of the benefits of resurfacing on the epidermis, as well as prevention of actinic neoplasia by adjusting any disturbance in the proliferation/apoptosis balance observed in photoaged facial skin.	co(2)	59-64	tumor protein p53	Homo sapiens	38-41
17353189-6	2007	Mass spectrometric analysis and the rate of cytosolic H(+) change following addition of CO(2)/HCO(3)(-) confirmed the catalytic activity of injected and expressed CAII in oocytes.	co(2)	88-93	carbonic anhydrase 2	Homo sapiens	163-167
17320198-13	2007	The marked increase in heart rate and the reduction in rCBF caused by decreased P(et)CO(2) are important dose-limiting factors to consider in future clinical studies.	co(2)	85-90	CCAAT/enhancer binding protein zeta	Rattus norvegicus	55-59
17171456-3	2007	Moreover, as the wettability of the Ti6Al4V alloy increased the adsorbed amounts of fibronectin increased, while the adsorbed amounts of albumin decreased--indicating the controllability of the CO(2) laser process.	co(2)	194-199	fibronectin 1	Homo sapiens	84-95
17483440-10	2007	The pathways that are uniquely induced by exercise in COPD (e.g., ubiquitin proteasome and COX) might indicate a greater degree of tissue stress (perhaps by altered O(2) and CO(2) dynamics) than in controls.	co(2)	174-179	cytochrome c oxidase subunit 8A	Homo sapiens	91-94
17127063-3	2007	The kinetic parameters for the CO(2) hydration reaction proved hCA VI to possess a k(cat) of 3.4x10(5)s(-1) and k(cat)/K(M) of 4.9x10(7)M(-1)s(-1) (at pH 7.5 and 20 degrees C).	co(2)	31-36	HCA1	Homo sapiens	63-66
17493376-13	2007	The Veress intraperitoneal (VIP-pressure </= 10 mm Hg) is a reliable indicator of correct intraperitoneal placement of the Veress needle; therefore, it is appropriate to attach the CO(2) source to the Veress needle on entry.	co(2)	184-189	vasoactive intestinal peptide	Homo sapiens	28-31
17111192-5	2007	We have verified this by measuring (14)CO(2) formation on incubation of 1-(14)C-PY with 3-morpholinosydnonimine (SIN-1).	co(2)	39-44	MAPK associated protein 1	Homo sapiens	113-118
17224163-5	2007	Based on structural comparison and functional complementation analyses, the active sites of SAICARs and AIRc were identified, including a putative substrate CO(2)-binding site.	co(2)	157-162	phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	Homo sapiens	104-108
17110510-2	2007	However, the cerebral blood flow (CBF)-Pet(CO(2)) relationship is nonlinear, even for moderate changes in CO(2).	co(2)	43-48	CCAAT enhancer binding protein zeta	Homo sapiens	34-37
17228367-1	2007	Carbonic anhydrase (CA) IV facilitates HCO(3) reabsorption in the renal proximal tubule by catalyzing the reversible hydration of CO(2).	co(2)	130-135	carbonic anhydrase 4	Rattus norvegicus	0-26
17352758-2	2007	In this study, we aim to assess the impact of the mechanism of injury on the secretion of transforming growth factor beta1 (TGF-beta1) and basic fibroblast growth factor (bFGF) in various stages of wound healing, in wounds created with a CO(2) laser and scalpel.	co(2)	238-243	transforming growth factor, beta 1	Rattus norvegicus	90-122
17352758-2	2007	In this study, we aim to assess the impact of the mechanism of injury on the secretion of transforming growth factor beta1 (TGF-beta1) and basic fibroblast growth factor (bFGF) in various stages of wound healing, in wounds created with a CO(2) laser and scalpel.	co(2)	238-243	transforming growth factor, beta 1	Rattus norvegicus	124-133
17352758-2	2007	In this study, we aim to assess the impact of the mechanism of injury on the secretion of transforming growth factor beta1 (TGF-beta1) and basic fibroblast growth factor (bFGF) in various stages of wound healing, in wounds created with a CO(2) laser and scalpel.	co(2)	238-243	fibroblast growth factor 2	Rattus norvegicus	139-169
17352758-2	2007	In this study, we aim to assess the impact of the mechanism of injury on the secretion of transforming growth factor beta1 (TGF-beta1) and basic fibroblast growth factor (bFGF) in various stages of wound healing, in wounds created with a CO(2) laser and scalpel.	co(2)	238-243	fibroblast growth factor 2	Rattus norvegicus	171-175
17352758-3	2007	Ten Wistar rats were used to determine the levels of growth factor proteins TGF-beta1 and bFGF after CO(2) laser- and scalpel-induced skin injury.	co(2)	101-106	fibroblast growth factor 2	Rattus norvegicus	90-94
17352758-8	2007	Laser energy alters local tissue secretion of TGF-beta1 and bFGF of skin injuries created with the CO(2) laser compared with wounds created with a scalpel.	co(2)	99-104	transforming growth factor, beta 1	Rattus norvegicus	46-55
17352758-8	2007	Laser energy alters local tissue secretion of TGF-beta1 and bFGF of skin injuries created with the CO(2) laser compared with wounds created with a scalpel.	co(2)	99-104	fibroblast growth factor 2	Rattus norvegicus	60-64
17215371-8	2007	The Asp-297-CO(2)(-)...Wat1 of reactant complex does play a crucial role in catalysis.	co(2)	12-17	MTOR associated protein, LST8 homolog	Homo sapiens	23-27
17215371-3	2007	Based on quantum mechanics/molecular mechanics (QM/MM) calculations, the free energy for MeOH reduction of o-PQQ when MeOH is hydrogen bonded to Glu-171-CO(2)(-) and the crystal water (Wat1) is hydrogen bonded to Asp-297-CO(2)(-) is DeltaG++ = 11.7 kcal/mol, which is comparable with the experimental value of 8.5 kcal/mol.	co(2)	221-226	MTOR associated protein, LST8 homolog	Homo sapiens	185-189
16934968-8	2007	Exercise ventilation (i.e., V(E)/V(CO2)) would partly be adjusted by the enhancement of the chemoreflex drive to CO(2) only during the steady-state exercise.	co(2)	113-118	complement C2	Homo sapiens	35-38
17068143-4	2007	In contrast, exposing these cells to CSF-1 in the presence of CO(2)/HCO(3)(-) causes a rapid and sustained cellular alkalinization.	co(2)	62-67	colony stimulating factor 1	Homo sapiens	37-42
17068143-8	2007	Moreover, CSF-1 promotes osteoclast survival in the presence of CO(2)/HCO(3)(-) buffer but not in its absence.	co(2)	64-69	colony stimulating factor 1	Homo sapiens	10-15
17056723-8	2007	We use the method to investigate the effect of reducing pH(i) on intrinsic (non-CO(2)/HCO(3)(-) buffer-dependent) and extrinsic (CO(2)/HCO(3)(-) buffer-dependent) components of H(i)(+)-mobility.	co(2)	80-85	glucose-6-phosphate isomerase	Rattus norvegicus	56-58
17056723-8	2007	We use the method to investigate the effect of reducing pH(i) on intrinsic (non-CO(2)/HCO(3)(-) buffer-dependent) and extrinsic (CO(2)/HCO(3)(-) buffer-dependent) components of H(i)(+)-mobility.	co(2)	129-134	glucose-6-phosphate isomerase	Rattus norvegicus	56-58
17215371-5	2007	The Asp-297-CO(2)(-)...Wat1 complex is very stable.	co(2)	12-17	MTOR associated protein, LST8 homolog	Homo sapiens	23-27
17215371-9	2007	By QM/MM calculation DeltaG++ = 1.1 kcal/mol for Asp-297-CO(2)(-) general-base catalysis of Wat1 hydration of the immediate CH(2)==O product --> CH(2)(OH)(2).	co(2)	57-62	MTOR associated protein, LST8 homolog	Homo sapiens	92-96
16998926-12	2006	From 24 to 336 h, peak and mean airway pressure, ventilator rate, and ventilatory efficiency index (VEI: PIP x R x CO(2)/1,000) were significantly greater in the VIP group at multiple time points.	co(2)	115-120	vasoactive intestinal peptide	Homo sapiens	162-165
17192478-7	2007	CO(2) production was significantly higher in the C/EBPbeta(-/-) mice as was the level of uncoupling protein (UCP)-1 and UCP-3 in the muscle.	co(2)	0-5	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	49-58
16959858-5	2006	A 100% increase in the chemoreflex gain (from 800 l min(-1) (fraction CO(2))(-1)) resulted in an increase in loop gain of 275 +/- 6% (P < 0.0001) across a wide range of values of steady state CO(2) and apnoea thresholds.	co(2)	70-75	CD59 molecule (CD59 blood group)	Homo sapiens	52-58
16959906-9	2007	Our findings suggest that orexin plays a crucial role both in CO(2) sensitivity during wakefulness and in preserving ventilation stability during sleep.	co(2)	62-67	hypocretin	Mus musculus	26-32
16902062-2	2006	Focal lesions of NK1R-ir neurons in the medullary raphe or the retrotrapezoid nucleus partially reduced the CO(2) response in conscious rats.	co(2)	108-113	tachykinin receptor 1	Rattus norvegicus	17-21
17048938-7	2006	In the present paper, by use of the model recently developed, the frequency of bubble formation from cellulose fibers is accessed and linked with various liquid and fiber parameters, namely, the concentration c(L) of CO(2)-dissolved molecules, the liquid temperature theta, its viscosity eta, the ambient pressure P, the course of the gas pocket growing trapped inside the fiber"s lumen before releasing a bubble, and the radius r of the fiber"s lumen.	co(2)	217-222	endothelin receptor type A	Homo sapiens	269-272
17010114-3	2006	A good candidate for this could be the Nicotiana tabacum L. aquaporin NtAQP1, which was shown to increase membrane permeability to CO(2) in Xenopus oocytes.	co(2)	131-136	probable aquaporin TIP1-1	Nicotiana tabacum	70-76
17010114-10	2006	These results provide evidence for the in vivo involvement of aquaporin NtAQP1 in mesophyll conductance to CO(2).	co(2)	107-112	probable aquaporin TIP1-1	Nicotiana tabacum	72-78
17028673-3	2006	The key to the success of the isolation of the active hydride catalysts is the change in the rate-determining step in the catalytic hydrogenation of CO(2) from the formation of the active hydride catalysts, [(eta(6)-C(6)Me(6))Ru(II)(L)(H)](+), to the reactions of [Cp*Ir(III)(L)(H)](+) with CO(2), as indicated by the kinetic studies.	co(2)	149-154	endothelin receptor type A	Homo sapiens	209-212
17028673-3	2006	The key to the success of the isolation of the active hydride catalysts is the change in the rate-determining step in the catalytic hydrogenation of CO(2) from the formation of the active hydride catalysts, [(eta(6)-C(6)Me(6))Ru(II)(L)(H)](+), to the reactions of [Cp*Ir(III)(L)(H)](+) with CO(2), as indicated by the kinetic studies.	co(2)	291-296	endothelin receptor type A	Homo sapiens	209-212
16763104-1	2006	Acute inhibition of serotonergic (5-HT) neurons in the medullary raphe (MR) using a 5-HT(1A) receptor agonist had an age-dependent impact on the "CO(2) response" of piglets (33).	co(2)	146-151	5-hydroxytryptamine receptor 1A	Homo sapiens	84-101
16794027-4	2006	From P0 to P14, CO(2) exposure increased pulmonary ventilation (Ve) by 25-50% in the BN and SD strains and between 25 to over 200% in the SS strain.	co(2)	16-21	SUB1 regulator of transcription	Rattus norvegicus	11-14
16794027-5	2006	In all strains beginning around P15, the response to CO(2) increased progressively reaching a peak at P19-21 when Ve during hypercapnia was 175-225% above eucapnia.	co(2)	53-58	cyclin-dependent kinase inhibitor 2B	Rattus norvegicus	32-35
16794027-8	2006	We conclude that 1) CO(2)-sensing mechanisms, and/or mechanisms downstream from the chemoreceptors, change dramatically at the age in rats when other physiological systems are also maturing ( approximately P15), and 2) there is a high degree of age-dependent plasticity in CO(2) sensitivity in rats, which differs between strains.	co(2)	20-25	cyclin-dependent kinase inhibitor 2B	Rattus norvegicus	206-209
21690823-6	2006	The saturation magnetization of stoichiometric Co(2)FeSi films turned out to be 1250 +- 120 emu cm(-3), being equivalent to 6.1 +- 0.57 (mu(B)/formula unit (fu)).	co(2)	47-52	ubiquitin like 3	Homo sapiens	137-142
16627483-1	2006	10-Formyltetrahydrofolate dehydrogenase (FDH) catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to CO(2) and tetrahydrofolate (THF) and is an abundant high affinity folate-binding protein.	co(2)	121-126	aldehyde dehydrogenase 1 family member L1	Homo sapiens	0-39
16627483-1	2006	10-Formyltetrahydrofolate dehydrogenase (FDH) catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to CO(2) and tetrahydrofolate (THF) and is an abundant high affinity folate-binding protein.	co(2)	121-126	aldehyde dehydrogenase 1 family member L1	Homo sapiens	41-44
16986841-11	2006	The rate is weakly dependent on the solution pH and is of the order of 10(-4) mol kg(-1) s(-1) at 330 degrees C. Furthermore, the equilibrium constant K(CO2) = [CO(2)][H(2)]/[HCOOH] is estimated to be 1.0 x10(2) mol kg(-1) at 330 degrees C.	co(2)	161-166	complement C2	Homo sapiens	151-156
16815866-1	2006	Phosphoenolpyruvate carboxylase (PEPC) catalyzes the irreversible carboxylation of phosphoenolpyruvate (PEP) and plays a crucial role in fixing atmospheric CO(2) in C(4) and CAM plants.	co(2)	156-161	phosphoenolpyruvate carboxykinase 1	Homo sapiens	0-31
16815866-1	2006	Phosphoenolpyruvate carboxylase (PEPC) catalyzes the irreversible carboxylation of phosphoenolpyruvate (PEP) and plays a crucial role in fixing atmospheric CO(2) in C(4) and CAM plants.	co(2)	156-161	phosphoenolpyruvate carboxykinase 1	Homo sapiens	33-37
16698771-4	2006	We present an extensive set of atomistic molecular dynamics simulations that address the question of CO(2) permeation through human aquaporin-1.	co(2)	101-106	aquaporin 1 (Colton blood group)	Homo sapiens	132-143
16698771-6	2006	The results indicate that significant aquaporin-1-mediated CO(2) permeation is to be expected only in membranes with a low intrinsic CO(2) permeability.	co(2)	59-64	aquaporin 1 (Colton blood group)	Homo sapiens	38-49
16698771-6	2006	The results indicate that significant aquaporin-1-mediated CO(2) permeation is to be expected only in membranes with a low intrinsic CO(2) permeability.	co(2)	133-138	aquaporin 1 (Colton blood group)	Homo sapiens	38-49
21690823-7	2006	The relatively close value of magnetic moment to the theoretically expected integer value (6 mu(B)) suggests that Co(2)FeSi films could be half-metallic ferromagnets.	co(2)	114-119	ubiquitin like 3	Homo sapiens	93-98
16764526-4	2006	With regard to CO(2) sensitivity, CMS subjects seem to have reset their central CO(2) chemoreceptors to operate around the sea-level resting P(ET(CO2)).	co(2)	15-20	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	123-126
16831598-10	2006	CONCLUSIONS: The duodenal hyperemic response to luminal CO(2) is dependent on cytosolic and membrane-bound CA isoforms, NHE-1, and TRPV1.	co(2)	56-61	solute carrier family 9 member A1	Rattus norvegicus	120-125
16831598-10	2006	CONCLUSIONS: The duodenal hyperemic response to luminal CO(2) is dependent on cytosolic and membrane-bound CA isoforms, NHE-1, and TRPV1.	co(2)	56-61	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	131-136
16831598-12	2006	NHE-1 activation preceding TRPV1 stimulation suggests that luminal CO(2) is sensed as H(+) in the subepithelium.	co(2)	67-72	solute carrier family 9 member A1	Rattus norvegicus	0-5
16831598-12	2006	NHE-1 activation preceding TRPV1 stimulation suggests that luminal CO(2) is sensed as H(+) in the subepithelium.	co(2)	67-72	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	27-32
16764526-4	2006	With regard to CO(2) sensitivity, CMS subjects seem to have reset their central CO(2) chemoreceptors to operate around the sea-level resting P(ET(CO2)).	co(2)	80-85	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	123-126
16777959-7	2006	Molecular analyses revealed that the Ad1/Pmp1 protein is encoded by LciB, a gene previously identified as a CO(2)-responsive gene.	co(2)	108-113	uncharacterized protein	Chlamydomonas reinhardtii	68-72
16777528-1	2006	Expression and activity of nitrate reductase (NR; EC 1.6.6.1) and glutamine synthetase (GS; EC 6.3.1.2) were analysed in relation to the rate of CO(2) assimilation in cucumber (Cucumis sativus L.) leaves.	co(2)	145-150	nitrate reductase [NADH]-like	Cucumis sativus	27-44
16777528-1	2006	Expression and activity of nitrate reductase (NR; EC 1.6.6.1) and glutamine synthetase (GS; EC 6.3.1.2) were analysed in relation to the rate of CO(2) assimilation in cucumber (Cucumis sativus L.) leaves.	co(2)	145-150	nitrate reductase [NADH]-like	Cucumis sativus	46-48
16777528-6	2006	At very low CO(2), NR and GS expression decreased, in spite of high nitrate contents, whereas at normal and elevated CO(2) expression and activity were high although the nitrate content was very low.	co(2)	12-17	nitrate reductase [NADH]-like	Cucumis sativus	19-21
17095410-13	2006	Another important practical consequence of the heating pattern is that the Nd:YAP pulses will activate warmth receptors more easily than CO(2).	co(2)	137-142	Yes1 associated transcriptional regulator	Homo sapiens	78-81
16518390-3	2006	With a high-throughput leaf thermal imaging CO(2) screen, we report the isolation of two allelic Arabidopsis mutants (high leaf temperature 1; ht1-1 and ht1-2) that are altered in their ability to control stomatal movements in response to CO(2).	co(2)	44-49	Protein kinase superfamily protein	Arabidopsis thaliana	143-146
16684511-4	2006	To further detect cPKC and nPKC isoforms activation following prolonged hypoxia in vitro, we tested the membrane translocation (an indicator of PKC activation) of cPKCalpha, betaI, betaII, and gamma, and nPKCdelta, epsilon, eta, mu, and theta in a human neuroblastoma SH-SY5Y cell line following sustained hypoxic exposure (1% O(2)/5% CO(2)/94% N(2)).	co(2)	335-340	protein kinase C delta	Homo sapiens	163-242
16735752-2	2006	Oocytes expressing rat brain NBCe1-B and exposed to a CO(2)/HCO(3)(-) solution displayed all the hallmarks of an electrogenic Na(+)/HCO(3)(-) cotransporter: (a) a DIDS-sensitive pH(i) recovery following the initial CO(2)-induced acidification, (b) an instantaneous hyperpolarization, and (c) an instantaneous Na(+)-dependent outward current under voltage-clamp conditions (-60 mV).	co(2)	54-59	solute carrier family 4 member 4 L homeolog	Xenopus laevis	29-34
16735752-2	2006	Oocytes expressing rat brain NBCe1-B and exposed to a CO(2)/HCO(3)(-) solution displayed all the hallmarks of an electrogenic Na(+)/HCO(3)(-) cotransporter: (a) a DIDS-sensitive pH(i) recovery following the initial CO(2)-induced acidification, (b) an instantaneous hyperpolarization, and (c) an instantaneous Na(+)-dependent outward current under voltage-clamp conditions (-60 mV).	co(2)	54-59	solute carrier family 4 member 4	Rattus norvegicus	126-155
16735752-2	2006	Oocytes expressing rat brain NBCe1-B and exposed to a CO(2)/HCO(3)(-) solution displayed all the hallmarks of an electrogenic Na(+)/HCO(3)(-) cotransporter: (a) a DIDS-sensitive pH(i) recovery following the initial CO(2)-induced acidification, (b) an instantaneous hyperpolarization, and (c) an instantaneous Na(+)-dependent outward current under voltage-clamp conditions (-60 mV).	co(2)	215-220	solute carrier family 4 member 4 L homeolog	Xenopus laevis	29-34
16735752-2	2006	Oocytes expressing rat brain NBCe1-B and exposed to a CO(2)/HCO(3)(-) solution displayed all the hallmarks of an electrogenic Na(+)/HCO(3)(-) cotransporter: (a) a DIDS-sensitive pH(i) recovery following the initial CO(2)-induced acidification, (b) an instantaneous hyperpolarization, and (c) an instantaneous Na(+)-dependent outward current under voltage-clamp conditions (-60 mV).	co(2)	215-220	solute carrier family 4 member 4	Rattus norvegicus	126-155
16450048-7	2006	Such an altered metabolism at HA suggested that PEPCase probably captured CO(2) directly from the atmosphere and/or that generated metabolically e.g. from photorespiration at HA.	co(2)	74-79	phosphoenolpyruvate carboxylase 2	Triticum aestivum	48-55
16518390-3	2006	With a high-throughput leaf thermal imaging CO(2) screen, we report the isolation of two allelic Arabidopsis mutants (high leaf temperature 1; ht1-1 and ht1-2) that are altered in their ability to control stomatal movements in response to CO(2).	co(2)	44-49	Protein kinase superfamily protein	Arabidopsis thaliana	153-158
16518390-3	2006	With a high-throughput leaf thermal imaging CO(2) screen, we report the isolation of two allelic Arabidopsis mutants (high leaf temperature 1; ht1-1 and ht1-2) that are altered in their ability to control stomatal movements in response to CO(2).	co(2)	239-244	Protein kinase superfamily protein	Arabidopsis thaliana	143-146
16518390-3	2006	With a high-throughput leaf thermal imaging CO(2) screen, we report the isolation of two allelic Arabidopsis mutants (high leaf temperature 1; ht1-1 and ht1-2) that are altered in their ability to control stomatal movements in response to CO(2).	co(2)	239-244	Protein kinase superfamily protein	Arabidopsis thaliana	153-158
16518390-4	2006	The strong allele, ht1-2, exhibits a markedly impaired CO(2) response but shows functional responses to blue light, fusicoccin and abscisic acid (ABA), indicating a role for HT1 in stomatal CO(2) signalling.	co(2)	55-60	Protein kinase superfamily protein	Arabidopsis thaliana	19-22
16518390-4	2006	The strong allele, ht1-2, exhibits a markedly impaired CO(2) response but shows functional responses to blue light, fusicoccin and abscisic acid (ABA), indicating a role for HT1 in stomatal CO(2) signalling.	co(2)	190-195	Protein kinase superfamily protein	Arabidopsis thaliana	19-22
16518390-4	2006	The strong allele, ht1-2, exhibits a markedly impaired CO(2) response but shows functional responses to blue light, fusicoccin and abscisic acid (ABA), indicating a role for HT1 in stomatal CO(2) signalling.	co(2)	190-195	Protein kinase superfamily protein	Arabidopsis thaliana	174-177
16518390-7	2006	Furthermore, dominant-negative HT1(K113W) transgenic plants, which lack HT1 kinase activity, show a disrupted CO(2) response.	co(2)	110-115	Protein kinase superfamily protein	Arabidopsis thaliana	31-34
16518390-7	2006	Furthermore, dominant-negative HT1(K113W) transgenic plants, which lack HT1 kinase activity, show a disrupted CO(2) response.	co(2)	110-115	Protein kinase superfamily protein	Arabidopsis thaliana	72-75
16518390-8	2006	These findings indicate that the HT1 kinase is important for regulation of stomatal movements and its function is more pronounced in response to CO(2) than it is to ABA or light.	co(2)	145-150	Protein kinase superfamily protein	Arabidopsis thaliana	33-36
16459157-2	2006	6-Phosphogluconate dehydrogenase (6PGD), an enzyme participating in this cycle, catalyzes the oxidative decarboxylation of 6PGD to ribulose 5-phosphate with the subsequent release of CO(2) and the reduction of NADP.	co(2)	183-188	6-phosphogluconate dehydrogenase, decarboxylating	Ceratitis capitata	0-32
16459157-2	2006	6-Phosphogluconate dehydrogenase (6PGD), an enzyme participating in this cycle, catalyzes the oxidative decarboxylation of 6PGD to ribulose 5-phosphate with the subsequent release of CO(2) and the reduction of NADP.	co(2)	183-188	6-phosphogluconate dehydrogenase, decarboxylating	Ceratitis capitata	34-38
16459157-2	2006	6-Phosphogluconate dehydrogenase (6PGD), an enzyme participating in this cycle, catalyzes the oxidative decarboxylation of 6PGD to ribulose 5-phosphate with the subsequent release of CO(2) and the reduction of NADP.	co(2)	183-188	6-phosphogluconate dehydrogenase, decarboxylating	Ceratitis capitata	123-127
16204407-10	2006	Regarding luminal ANG II, fractional stimulation produced by 10(-11) M ANG II fell monotonically as [CO(2)](BL) rose from 0 to 20%.	co(2)	101-106	angiogenin	Oryctolagus cuniculus	71-74
16204407-11	2006	Fractional inhibition produced by 10(-9) M ANG II rose monotonically with increasing [CO(2)](BL).	co(2)	86-91	angiogenin	Oryctolagus cuniculus	43-46
16204407-8	2006	Fractional stimulation produced by BL 10(-11) M ANG II falls when [CO(2)](BL) exceeds 5%.	co(2)	67-72	angiogenin	Oryctolagus cuniculus	48-51
16204407-12	2006	Viewed differently, ANG II at 10(-11) M tended to reduce stimulation by CO(2), and at 10(-9) M, produced an even greater reduction.	co(2)	72-77	angiogenin	Oryctolagus cuniculus	20-23
16204407-9	2006	Fractional inhibition produced by BL 10(-9) M ANG II tends to rise when [CO(2)](BL) exceeds 5%.	co(2)	73-78	angiogenin	Oryctolagus cuniculus	46-49
16204407-13	2006	In conclusion, the mutual effects of 1) ANG II on the J(HCO(3)) response to basolateral CO(2) and 2) basolateral CO(2) on the J(HCO(3)) responses to ANG II suggest that the signal-transduction pathways for ANG II and basolateral CO(2) intersect or merge.	co(2)	88-93	angiogenin	Oryctolagus cuniculus	40-43
16247573-11	2006	RESULTS: MCP-1 levels were significantly greater and higher earlier in group 2 (CO(2)-LC) than in group 1 (LAP) (p < 0.007).	co(2)	80-85	chemokine (C-C motif) ligand 2	Mus musculus	9-14
16205953-7	2006	The activities of 1,4-beta-glucosidase (+37%) and 1,4,-beta-N-acetylglucosaminidase (+84%) were significantly increased under elevated CO(2), whereas 1,4-beta-glucosidase activity (-25%) was significantly suppressed by elevated O(3).	co(2)	135-140	O-GlcNAcase	Homo sapiens	55-83
16415064-6	2006	TpS-11 and TpS-10 plants with 1.6- and 4.3-fold higher SBPase activity, respectively, showed an increase in the photosynthetic CO(2) fixation, growth rate, RuBP contents and Rubisco activation state, while TpS-2 plants with 1.3-fold higher SBPase showed the same phenotype as the wild-type plants.	co(2)	127-132	alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1-like	Nicotiana tabacum	0-3
16415064-6	2006	TpS-11 and TpS-10 plants with 1.6- and 4.3-fold higher SBPase activity, respectively, showed an increase in the photosynthetic CO(2) fixation, growth rate, RuBP contents and Rubisco activation state, while TpS-2 plants with 1.3-fold higher SBPase showed the same phenotype as the wild-type plants.	co(2)	127-132	alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1-like	Nicotiana tabacum	11-14
16415064-6	2006	TpS-11 and TpS-10 plants with 1.6- and 4.3-fold higher SBPase activity, respectively, showed an increase in the photosynthetic CO(2) fixation, growth rate, RuBP contents and Rubisco activation state, while TpS-2 plants with 1.3-fold higher SBPase showed the same phenotype as the wild-type plants.	co(2)	127-132	alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1-like	Nicotiana tabacum	11-14
16878340-4	2006	The elimination of CO(2) (rather than CH(3)CHO or C(3)H(8)), which was confirmed by an exact mass measurement using the Q-TOF instrument, represented a major fragmentation pathway in the 2-D linear ion trap mass spectrometer.	co(2)	19-24	FEZ family zinc finger 2	Homo sapiens	122-125
16458591-3	2006	Skeletal muscle and possibly liver seem to be the main organs involved in the action of IL-15 on lipid oxidation, since the presence of the cytokine in incubated EDL muscle with [(14)C]-palmitic acid increased (14)CO(2) formation by 39%.	co(2)	214-219	interleukin 15	Rattus norvegicus	88-93
16567937-5	2006	METHODS: The CO(2) reactivity of the middle cerebral artery was examined using transcranial Doppler ultrasonography in 81 DM2 patients and 38 controls.	co(2)	13-18	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	122-125
16467767-3	2006	Stimulated PBMCs were incubated in CO(2) for production of interferon-gamma (IFN-gamma), which was measured from the supernatant of cultured PBMCs by an in-house ELISA technique.	co(2)	35-40	interferon gamma	Homo sapiens	59-75
16467767-3	2006	Stimulated PBMCs were incubated in CO(2) for production of interferon-gamma (IFN-gamma), which was measured from the supernatant of cultured PBMCs by an in-house ELISA technique.	co(2)	35-40	interferon gamma	Homo sapiens	77-86
16367955-1	2006	Serine hydroxymethyltransferase (SHMT) is part of the mitochondrial enzyme complex catalysing the photorespiratory production of serine, ammonium and CO(2) from glycine.	co(2)	150-155	serine hydroxymethyltransferase, mitochondrial	Solanum tuberosum	0-31
16367955-1	2006	Serine hydroxymethyltransferase (SHMT) is part of the mitochondrial enzyme complex catalysing the photorespiratory production of serine, ammonium and CO(2) from glycine.	co(2)	150-155	serine hydroxymethyltransferase, mitochondrial	Solanum tuberosum	33-37
16049140-5	2005	Two days after LPS, Vc/C1 units had reduced responses to histamine, nicotine, and CO(2) gas applied to the ocular surface, whereas unit responses were increased 7 days after LPS.	co(2)	82-87	C-X-C motif chemokine ligand 17	Homo sapiens	20-25
16222055-10	2005	Despite the decrease in adipocyte CPT-I mRNA and specific activity, CO(2) production from endogenous FFAs increased, suggesting increased FFA transport through CPT-I for beta-oxidation.	co(2)	68-73	carnitine palmitoyltransferase 1B	Rattus norvegicus	160-165
15958523-10	2005	These findings demonstrate that sAC signaling pathway is involved in the regulation of CFTR function in human airway epithelium and thereby provides a link between the level of intracellular HCO(3)(-)/CO(2) and the modulation of HCO(3)(-)-conductive CFTR function by cAMP/PKA.	co(2)	201-206	CF transmembrane conductance regulator	Homo sapiens	87-91
16155228-6	2005	Trehalase, glycogen phosphorylase and hexokinase activities are sufficient to account for the glycolytic flux rates estimated from rates of CO(2) production.	co(2)	140-145	trehalase	Apis mellifera	0-9
16155228-6	2005	Trehalase, glycogen phosphorylase and hexokinase activities are sufficient to account for the glycolytic flux rates estimated from rates of CO(2) production.	co(2)	140-145	glycogen phosphorylase	Apis mellifera	11-33
16155228-6	2005	Trehalase, glycogen phosphorylase and hexokinase activities are sufficient to account for the glycolytic flux rates estimated from rates of CO(2) production.	co(2)	140-145	hexokinase type 2	Apis mellifera	38-48
15897321-5	2005	In contrast, long-term CO(2) production was reduced by FATP1 and FAT at all doses of palmitate and at the lower concentrations of oleate.	co(2)	23-28	solute carrier family 27 member 1	Homo sapiens	55-60
15778246-8	2005	Increasing CO(2) decreased TNF-alpha secretion but had no effect on lysate TNF-alpha.	co(2)	11-16	tumor necrosis factor	Rattus norvegicus	27-36
15778246-9	2005	Buffering the media abated the effects of CO(2) on TNF-alpha secretion.	co(2)	42-47	tumor necrosis factor	Rattus norvegicus	51-60
15946639-1	2005	Augmentation, by CO(2)/HCO(3)(-), of Co(II)-catalyzed peroxidations was explored to clarify whether the rate enhancement was due to CO(2) or to HCO(3)(-).	co(2)	17-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
15946639-2	2005	The rate of oxidation of NADH by Co(II) plus H(2)O(2), in Tris or phosphate, was markedly enhanced by CO(2)/HCO(3)(-).	co(2)	102-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
15879495-7	2005	CYP2E1+/+ mice administered single or multiple doses exhaled 78 to 88% of dose as (14)CO(2)/day.	co(2)	86-91	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	0-6
15802365-1	2005	The objective of this study was to evaluate the effects of lung perfusion on the slopes of phases II (S(II)) and III (S(III)) of a single-breath test of CO(2) (SBT-CO(2)).	co(2)	153-158	transcription elongation factor A1	Homo sapiens	102-107
15802365-1	2005	The objective of this study was to evaluate the effects of lung perfusion on the slopes of phases II (S(II)) and III (S(III)) of a single-breath test of CO(2) (SBT-CO(2)).	co(2)	153-158	elongin B	Homo sapiens	118-124
15802365-1	2005	The objective of this study was to evaluate the effects of lung perfusion on the slopes of phases II (S(II)) and III (S(III)) of a single-breath test of CO(2) (SBT-CO(2)).	co(2)	164-169	elongin B	Homo sapiens	118-124
15802365-11	2005	Normalizing S(II) and S(III) eliminated the effect of changes in the magnitude of PBF on the shape of the SBT-CO(2) curve.	co(2)	110-115	transcription elongation factor A1	Homo sapiens	12-17
15802365-11	2005	Normalizing S(II) and S(III) eliminated the effect of changes in the magnitude of PBF on the shape of the SBT-CO(2) curve.	co(2)	110-115	elongin B	Homo sapiens	22-28
15962356-2	2005	The analysis revealed that loss of CO(2)[M + H - 44](+) is the predominant process for compounds that exhibit a hydroxyl at C-8.	co(2)	35-40	homeobox C8	Homo sapiens	124-127
15677379-1	2005	The effect of CO(2)-induced acidification on transjunctional voltage (V(j)) gating was studied by dual voltage-clamp in oocytes expressing mouse connexin 50 (Cx50) or a Cx50 mutant (Cx50-D3N), in which the third residue, aspartate (D), was mutated to asparagine (N).	co(2)	14-19	gap junction protein, alpha 8	Mus musculus	158-162
15677379-1	2005	The effect of CO(2)-induced acidification on transjunctional voltage (V(j)) gating was studied by dual voltage-clamp in oocytes expressing mouse connexin 50 (Cx50) or a Cx50 mutant (Cx50-D3N), in which the third residue, aspartate (D), was mutated to asparagine (N).	co(2)	14-19	gap junction protein, alpha 8	Mus musculus	169-173
15677379-1	2005	The effect of CO(2)-induced acidification on transjunctional voltage (V(j)) gating was studied by dual voltage-clamp in oocytes expressing mouse connexin 50 (Cx50) or a Cx50 mutant (Cx50-D3N), in which the third residue, aspartate (D), was mutated to asparagine (N).	co(2)	14-19	gap junction protein, alpha 8	Mus musculus	169-173
15677379-3	2005	CO(2) application greatly decreased the V(j) sensitivity of Cx50 channels, and increased that of Cx50-D3N channels.	co(2)	0-5	gap junction protein, alpha 8	Mus musculus	60-64
15677379-3	2005	CO(2) application greatly decreased the V(j) sensitivity of Cx50 channels, and increased that of Cx50-D3N channels.	co(2)	0-5	gap junction protein, alpha 8	Mus musculus	97-101
15677379-4	2005	CO(2) also affected the kinetics of V(j) dependent inactivation of junctional current (I(j)), decreasing the gating speed of Cx50 channels and increasing that of Cx50-D3N channels.	co(2)	0-5	gap junction protein, alpha 8	Mus musculus	125-129
15677379-4	2005	CO(2) also affected the kinetics of V(j) dependent inactivation of junctional current (I(j)), decreasing the gating speed of Cx50 channels and increasing that of Cx50-D3N channels.	co(2)	0-5	gap junction protein, alpha 8	Mus musculus	162-166
15677522-7	2005	For the puzzle paradigm, CBFV changed by 13.9 +/- 6.6% (right MCA, P = 0.0007) and by 11.5 +/- 6.2% (left MCA, P = 0.0007), ABP by 7.1 +/- 8.4 mmHg (P = 0.0054), heart rate by 7.9 +/- 4.6 beats/min (P = 0.0008), and Pet(CO(2)) by -2.42 +/- 2.59 Torr (P = 0.001).	co(2)	220-225	amine oxidase copper containing 1	Homo sapiens	124-127
15897321-5	2005	In contrast, long-term CO(2) production was reduced by FATP1 and FAT at all doses of palmitate and at the lower concentrations of oleate.	co(2)	23-28	CD36 molecule	Homo sapiens	55-58
16007391-6	2005	The time vs (13)CO(2) excretion rate curve was mathematically fitted to a conventional formula of y (t) = m*k*beta*e(-k*t)*(1 - e(-k*t))(beta-1), and the parameters of k and beta were determined: under the crossover protocol, a larger (smaller) beta indicates slower (faster) emptying in the early phase, and a larger (smaller) k indicates faster (slower) emptying in the later phase.	co(2)	16-21	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	137-143
15901897-11	2005	In addition, CA XIV may facilitate CO(2) removal from neural retina and modulate photoreceptor function.	co(2)	35-40	carbonic anhydrase 14	Homo sapiens	13-19
15888509-10	2005	Subjective feelings of anxiety and, correspondingly, cortisol and ACTH levels, were found to be significantly increased following the 35% CO(2) challenge.	co(2)	138-143	proopiomelanocortin	Homo sapiens	66-70
15888509-11	2005	Cortisol and ACTH responses to CO(2) were also associated.	co(2)	31-36	proopiomelanocortin	Homo sapiens	13-17
15807537-3	2005	Human carbonic anhydrase II (hCAII) is an enzyme that evolved to catalyze the reversible hydration of CO(2) and performs this task at a remarkable rate (k(cat) approximately 10(6) s(-)(1)).	co(2)	102-107	carbonic anhydrase 2	Homo sapiens	6-27
15807537-3	2005	Human carbonic anhydrase II (hCAII) is an enzyme that evolved to catalyze the reversible hydration of CO(2) and performs this task at a remarkable rate (k(cat) approximately 10(6) s(-)(1)).	co(2)	102-107	carbonic anhydrase 2	Homo sapiens	29-34
16851119-3	2005	Over Na-Y, the reaction between HCN and NO(2) is slow at 473 K. On Ba-Y, HCN reacts readily with NO(2) at 473K, forming N(2), CO, CO(2), HNCO, NO, N(2)O, and C(2)N(2).	co(2)	130-135	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	73-76
15499081-9	2005	Dimethyl amiloride (0.1 mM), an inhibitor of the basolateral sodium-hydrogen exchanger 1, also inhibited CO(2)-augumented DBS, although S-3226, a specific inhibitor of apical sodium-hydrogen exchanger 3, did not.	co(2)	105-110	solute carrier family 9 member A1	Rattus norvegicus	61-88
15801799-6	2005	We examined whether overexpression of NHE1 would provide CHO cells with greater protection from elevated ammonia, lactate or CO(2).	co(2)	125-130	sodium/hydrogen exchanger 1	Cricetulus griseus	38-42
15686895-4	2005	hCA VII shows a high catalytic activity for the CO(2) hydration reaction, with a k(cat) of 9.5 x 10(5)s(-1) and k(cat)/K(m) of 8.3 x 10(7)M(-1)s(-1) at pH7.5 and 20 degrees C. A very interesting inhibition profile against hCA VII with this series of 32 sulfonamides/sulfamates was observed.	co(2)	48-53	carbonic anhydrase 7	Homo sapiens	0-7
15686895-4	2005	hCA VII shows a high catalytic activity for the CO(2) hydration reaction, with a k(cat) of 9.5 x 10(5)s(-1) and k(cat)/K(m) of 8.3 x 10(7)M(-1)s(-1) at pH7.5 and 20 degrees C. A very interesting inhibition profile against hCA VII with this series of 32 sulfonamides/sulfamates was observed.	co(2)	48-53	carbonic anhydrase 7	Homo sapiens	222-229
15539434-4	2005	In the presence of HCO(3)(-) (24 meq, bubbled with 5% CO(2)), however, the V(h,ACh) was not blocked by bumetanide, but it was suppressed by ethylisopropylamiloride (EIPA), a Na(+)/H(+) exchanger (NHE) inhibitor.	co(2)	54-59	acyl-CoA thioesterase 12	Rattus norvegicus	79-82
15813743-9	2005	Inactivation of NCE103 results in a high CO(2) requiring mutant indicating that a functional CA is an important prerequisite for S. cerevisiae to grow under low-Ci conditions.	co(2)	41-46	carbonate dehydratase NCE103	Saccharomyces cerevisiae S288C	16-22
15703060-7	2005	NO emission in vivo by NiR-mutant leaves (which was not nitrite limited) was proportional to photosynthesis (high in light +CO(2), low in light -CO(2), or in the dark).	co(2)	124-129	ferredoxin--nitrite reductase, chloroplastic-like	Nicotiana tabacum	23-26
15703060-7	2005	NO emission in vivo by NiR-mutant leaves (which was not nitrite limited) was proportional to photosynthesis (high in light +CO(2), low in light -CO(2), or in the dark).	co(2)	145-150	ferredoxin--nitrite reductase, chloroplastic-like	Nicotiana tabacum	23-26
15634339-2	2005	Directly after surgery and cell isolation, adipocytes were insulin resistant, but this was reversed after overnight incubation in 10% CO(2) at 37 degrees C. Tyrosine phosphorylation of the insulin receptor and insulin receptor substrate (IRS)1 was insulin sensitive, but protein kinase B (PKB) and downstream metabolic effects exhibited insulin resistance that was reversed by overnight incubation.	co(2)	134-139	insulin	Homo sapiens	189-196
16851014-7	2005	(iv) Concentrated solutions of UO(2)L(2)(TBP) complexes at the CO(2)-water interface display an equilibrium between adsorbed and extracted species, and the proportion of extracted species is larger with F- than with H- ligands, in agreement with experimental observations.	co(2)	63-68	TATA-box binding protein	Homo sapiens	41-44
16851014-8	2005	Thus, TBP plays a dual synergistic role: its co-complexation by UO(2)L(2) yields a hydrophobic and CO(2)-philic complex suitable for extraction, whereas TBP in excess at the interface facilitates the migration of the complex to the supercritical phase.	co(2)	99-104	TATA-box binding protein	Homo sapiens	6-9
15634339-2	2005	Directly after surgery and cell isolation, adipocytes were insulin resistant, but this was reversed after overnight incubation in 10% CO(2) at 37 degrees C. Tyrosine phosphorylation of the insulin receptor and insulin receptor substrate (IRS)1 was insulin sensitive, but protein kinase B (PKB) and downstream metabolic effects exhibited insulin resistance that was reversed by overnight incubation.	co(2)	134-139	protein tyrosine kinase 2 beta	Homo sapiens	271-287
15634339-2	2005	Directly after surgery and cell isolation, adipocytes were insulin resistant, but this was reversed after overnight incubation in 10% CO(2) at 37 degrees C. Tyrosine phosphorylation of the insulin receptor and insulin receptor substrate (IRS)1 was insulin sensitive, but protein kinase B (PKB) and downstream metabolic effects exhibited insulin resistance that was reversed by overnight incubation.	co(2)	134-139	protein tyrosine kinase 2 beta	Homo sapiens	289-292
15634339-2	2005	Directly after surgery and cell isolation, adipocytes were insulin resistant, but this was reversed after overnight incubation in 10% CO(2) at 37 degrees C. Tyrosine phosphorylation of the insulin receptor and insulin receptor substrate (IRS)1 was insulin sensitive, but protein kinase B (PKB) and downstream metabolic effects exhibited insulin resistance that was reversed by overnight incubation.	co(2)	134-139	insulin	Homo sapiens	189-196
15501038-1	2004	The membrane-associated human isozyme of carbonic anhydrase, hCA IV, has been investigated for its interaction with anion inhibitors, for the CO(2) hydration reaction catalyzed by this enzyme.	co(2)	142-147	carbonic anhydrase 4	Homo sapiens	61-67
15567346-7	2004	cDA inhibited (14)CO(2) production from all tested substrates by around 30-40%.	co(2)	18-23	cytidine deaminase	Rattus norvegicus	0-3
15551322-2	2004	The helicates, formulated as [Co(2)(L)(2)(L-H)(2)X(2)], readily self-assemble from a mixture of a suitable pyridine-alcohol compound (L; for example, 6-methylpyridine-2-methanol, 1), and a CoX(2) salt in the presence of base.	co(2)	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
15634998-6	2005	Culture at 35 degrees C in 6% O(2)-10% CO(2) significantly enhanced the recovery of Aspergillus spp.	co(2)	39-44	histocompatibility minor 13	Homo sapiens	96-99
15537939-5	2004	Treating an aqueous RDX solution of 2.8 mg L(-1) with 20000 mg KMnO(4) L(-1) decreased RDX to 0.1 mg L(-1) within 11 d while cumulative mineralization proceeded for 14 d until 87% of the labeled carbon was trapped as (14)CO(2).	co(2)	221-226	radixin	Homo sapiens	20-23
15798904-4	2004	To test this hypothesis, we have studied the CO(2)-mediated changes in V(j) gating in channels made of Cx32, Cx26, or a Cx32 mutant (Cx32-N2D) in which asparagine (N) at position 2 was replaced with aspartate (D).	co(2)	45-50	gap junction protein beta 1	Homo sapiens	103-107
15798904-5	2004	With exposure to CO(2), Cx32 channels (negative gaters) show increased V(j)-dependent closure, whereas Cx26 channels (positive gaters) respond in the opposite way to V(j).	co(2)	17-22	gap junction protein beta 1	Homo sapiens	24-28
15798904-6	2004	Additionally, Cx32-N2D channels (positive gaters) show decreased V(j) closure with exposure to CO(2).	co(2)	95-100	gap junction protein beta 1	Homo sapiens	14-18
15582232-10	2004	The changes in CVR correlated with those in RAP (p = 0.008 for the 5% CO(2) test and p = 0.014 for the hyperventilation test).	co(2)	70-75	LDL receptor related protein associated protein 1	Homo sapiens	44-47
15278153-1	2004	FAU-type zeolite membranes were synthesized by the vapor phase transformation (VPT) methods with or without prior seeding on the substrate, and it was revealed that the CO(2)/N(2) selectivity of the seeded membrane is greater than that of the unseeded membrane.	co(2)	169-174	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	0-3
15520908-0	2004	CO(2) sensitivity of voltage gating and gating polarity of gapjunction channels--connexin40 and its COOH-terminus-truncated mutant.	co(2)	0-5	gap junction protein, alpha 5	Mus musculus	81-91
15274622-2	2004	Of nine known ACDs, glutaryl-CoA dehydrogenase (GCD) is unique: in addition to the alpha,beta-dehydrogenation reaction, common to all ACDs, GCD catalyzes decarboxylation of glutaryl-CoA to produce CO(2) and crotonyl-CoA.	co(2)	197-202	glutaryl-CoA dehydrogenase	Homo sapiens	20-46
15274622-2	2004	Of nine known ACDs, glutaryl-CoA dehydrogenase (GCD) is unique: in addition to the alpha,beta-dehydrogenation reaction, common to all ACDs, GCD catalyzes decarboxylation of glutaryl-CoA to produce CO(2) and crotonyl-CoA.	co(2)	197-202	glutaryl-CoA dehydrogenase	Homo sapiens	48-51
15274622-2	2004	Of nine known ACDs, glutaryl-CoA dehydrogenase (GCD) is unique: in addition to the alpha,beta-dehydrogenation reaction, common to all ACDs, GCD catalyzes decarboxylation of glutaryl-CoA to produce CO(2) and crotonyl-CoA.	co(2)	197-202	glutaryl-CoA dehydrogenase	Homo sapiens	140-143
15310643-6	2004	The elimination of CO(2) per breath increased during PEEP (25 +/- 3.3 mL.min(-1)) and ARS (27 +/- 3.2 mL.min(-1)) compared to ZEEP (23 +/- 2.6 mL.min(-1), P < 0.05), although ARS showed larger values than PEEP (P < 0.05).	co(2)	19-24	RIEG2	Homo sapiens	86-89
15310643-6	2004	The elimination of CO(2) per breath increased during PEEP (25 +/- 3.3 mL.min(-1)) and ARS (27 +/- 3.2 mL.min(-1)) compared to ZEEP (23 +/- 2.6 mL.min(-1), P < 0.05), although ARS showed larger values than PEEP (P < 0.05).	co(2)	19-24	RIEG2	Homo sapiens	178-181
15258181-9	2004	By reversible hydration of CO(2), CA VI is presumed to play a role in mucosal functions such as CO(2) sensation and acid-base balance.	co(2)	27-32	carbonic anhydrase 6	Mus musculus	34-39
15258181-9	2004	By reversible hydration of CO(2), CA VI is presumed to play a role in mucosal functions such as CO(2) sensation and acid-base balance.	co(2)	96-101	carbonic anhydrase 6	Mus musculus	34-39
15520908-1	2004	The CO(2) sensitivity of transjunctional voltage ( V(j)) gating was studied by dual voltage clamp in oocytes expressing mouse Cx40 or its COOH terminus (CT)-truncated mutant (Cx40-TR).	co(2)	4-9	gap junction protein, alpha 5	Mus musculus	126-130
15520908-1	2004	The CO(2) sensitivity of transjunctional voltage ( V(j)) gating was studied by dual voltage clamp in oocytes expressing mouse Cx40 or its COOH terminus (CT)-truncated mutant (Cx40-TR).	co(2)	4-9	gap junction protein, alpha 5	Mus musculus	175-179
15520908-6	2004	The sensitivity of Cx40 channels to 100% CO(2) was also unaffected by CT truncation.	co(2)	41-46	gap junction protein, alpha 5	Mus musculus	19-23
15520908-7	2004	There is evidence that CO(2) decreases the V(j) sensitivity of Cx26, Cx50 and Cx37 as well, whereas it increases that of Cx45 and Cx32 channels.	co(2)	23-28	gap junction protein, beta 2	Mus musculus	63-67
15520908-7	2004	There is evidence that CO(2) decreases the V(j) sensitivity of Cx26, Cx50 and Cx37 as well, whereas it increases that of Cx45 and Cx32 channels.	co(2)	23-28	gap junction protein, alpha 8	Mus musculus	69-73
15520908-7	2004	There is evidence that CO(2) decreases the V(j) sensitivity of Cx26, Cx50 and Cx37 as well, whereas it increases that of Cx45 and Cx32 channels.	co(2)	23-28	gap junction protein, alpha 4	Mus musculus	78-82
15520908-7	2004	There is evidence that CO(2) decreases the V(j) sensitivity of Cx26, Cx50 and Cx37 as well, whereas it increases that of Cx45 and Cx32 channels.	co(2)	23-28	gap junction protein, gamma 1	Mus musculus	121-125
15520908-7	2004	There is evidence that CO(2) decreases the V(j) sensitivity of Cx26, Cx50 and Cx37 as well, whereas it increases that of Cx45 and Cx32 channels.	co(2)	23-28	gap junction protein, beta 1	Mus musculus	130-134
14962837-12	2004	Disruption of GL gap junctional communication, using an antisense oligodeoxynucleotide (ODN) connexin43 knockdown approach, was accompanied by a 33% lower CO(2) reactivity versus missense ODN-treated controls.	co(2)	155-160	gap junction protein, alpha 1	Rattus norvegicus	93-103
15162417-3	2004	This study investigates the fundamental interactions between the human serum albumin (no-cell adhesive) and human plasma fibronectin and bioinert ceramic following CO(2) laser treatment.	co(2)	164-169	albumin	Homo sapiens	71-84
15162417-3	2004	This study investigates the fundamental interactions between the human serum albumin (no-cell adhesive) and human plasma fibronectin and bioinert ceramic following CO(2) laser treatment.	co(2)	164-169	fibronectin 1	Homo sapiens	121-132
15162417-4	2004	The analysis of the albumin and fibronectin adsorption was conducted on the untreated and CO(2) laser-modified magnesia partially stabilized zirconia (MgO-PSZ) bioceramic using an ellipsometry.	co(2)	90-95	fibronectin 1	Homo sapiens	32-43
14736710-2	2004	Cytosolic enzyme carbonic anhydrase II (CAII) catalyzes the reaction CO(2) + H(2)O left arrow over right arrow HCO(3)(-) + H(+) in many tissues.	co(2)	69-74	carbonic anhydrase 2	Homo sapiens	17-38
14736710-2	2004	Cytosolic enzyme carbonic anhydrase II (CAII) catalyzes the reaction CO(2) + H(2)O left arrow over right arrow HCO(3)(-) + H(+) in many tissues.	co(2)	69-74	carbonic anhydrase 2	Homo sapiens	40-44
15256086-5	2004	These cells were incubated in 5% CO(2) for 4 h-4.5 h. The membrane and plasma of CD4+ helper T cells were marked by CD3 -PC5 + CD8 -FITC + INF-gamma -PE/CD3 -PC5 + CD8 -FITC + IgG1 -PE, CD3 -PC5 + CD8 -FITC + IL-4 -PE/CD3 -PC5 + CD8 -FITC + IgG1 -PE monoclonal antibodies respectively.	co(2)	33-38	CD4 molecule	Homo sapiens	81-84
15026783-2	2004	The activity of glycerol kinase (GK) in cultured fibroblasts was determined with a specific enzyme assay and with two indirect methods, that is, incorporation into macromolecules of [(14)C] from [(14)C]glycerol and its oxidation to [(14)C]CO(2).	co(2)	239-244	glycerol kinase	Homo sapiens	16-31
15026783-2	2004	The activity of glycerol kinase (GK) in cultured fibroblasts was determined with a specific enzyme assay and with two indirect methods, that is, incorporation into macromolecules of [(14)C] from [(14)C]glycerol and its oxidation to [(14)C]CO(2).	co(2)	239-244	glycerol kinase	Homo sapiens	33-35
15026783-5	2004	In patient 2 with a considerable activity of the GK enzyme (22% of reference), oxidation to [(14)C]CO(2) (37%) and a high incorporation of [(14)C] into macromolecules (92%), we identified a c.182T>C (L61P) mutation that causes the enzyme to have a higher K(m) for glycerol ( approximately 300 microM) than normals (2-8 microM).	co(2)	99-104	glycerol kinase	Homo sapiens	49-51
15104788-1	2004	UNLABELLED: The population distributions of CO(2)-induced irritation sensitivity in the eyes (COI), tear film stability (break-up time, BUT), and epithelium damage (ED) and the relation of these to basic potential confounders were assessed in an age- and gender-stratified random sample of citizens in Aarhus County, Denmark.	co(2)	44-49	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	94-97
15104788-4	2004	The BUT was non-normally distributed, as was COI at 16% CO(2) and single ED-scores.	co(2)	56-61	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	45-48
15256086-5	2004	These cells were incubated in 5% CO(2) for 4 h-4.5 h. The membrane and plasma of CD4+ helper T cells were marked by CD3 -PC5 + CD8 -FITC + INF-gamma -PE/CD3 -PC5 + CD8 -FITC + IgG1 -PE, CD3 -PC5 + CD8 -FITC + IL-4 -PE/CD3 -PC5 + CD8 -FITC + IgG1 -PE monoclonal antibodies respectively.	co(2)	33-38	CD8a molecule	Homo sapiens	127-130
15086820-11	2004	FTIR spectroscopy indicated a relative increase in guaiacyl- as compared with syringyl-units in antisense-OMT tobacco, which was more pronounced under elevated as compared with ambient CO(2).	co(2)	185-190	caffeic acid 3-O-methyltransferase-like	Nicotiana tabacum	106-109
15120068-8	2004	Analysis reveals that GC1-deficient giant chloroplasts contain densely packed wild-type-like thylakoid membranes and that GC1-deficient leaves exhibit lower rates of CO(2) assimilation compared to wild-type.	co(2)	166-171	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	122-125
15075205-9	2004	We conclude that CO(2) modulation of colonic, but not ileal, Cl(-) absorption involves effects on vesicular trafficking of AE1.	co(2)	17-22	solute carrier family 4 member 1 (Diego blood group)	Rattus norvegicus	123-126
15064893-2	2004	Using two identical CO(2)-laser stimulators, we delivered paired stimuli to two adjacent skin spots on the hand at interstimulus intervals ranging from 250 ms to 2 s. The test P2-LEP was strongly inhibited at the 250-ms interstimulus interval ( P<0.01) and progressively recovered by the 2-s interval.	co(2)	20-25	leptin	Homo sapiens	179-182
15169933-0	2004	Overexpression of the barley aquaporin HvPIP2;1 increases internal CO(2) conductance and CO(2) assimilation in the leaves of transgenic rice plants.	co(2)	67-72	HvPIP2;1	Hordeum vulgare	39-47
15169933-0	2004	Overexpression of the barley aquaporin HvPIP2;1 increases internal CO(2) conductance and CO(2) assimilation in the leaves of transgenic rice plants.	co(2)	89-94	HvPIP2;1	Hordeum vulgare	39-47
15169933-6	2004	The transgenic plants that had low levels of Aq-anti-HvPIP2;1 showed decreases in g(i) and CO(2) assimilation rate.	co(2)	91-96	HvPIP2;1	Hordeum vulgare	53-61
15070393-2	2004	CAII, through the Zn(2+)-bound hydroxide, catalyzes the deceptively simple reaction: CO(2) + H(2)O <==> HCO(3)(-) + H(+).	co(2)	85-90	carbonic anhydrase 2	Homo sapiens	0-4
14724181-2	2004	In TRCs perfused with CO(2)/HCO(3)(-)-free solution (pH 7.4), removal of basolateral Na(+) decreased pH(i) reversibly and zoniporide, a specific NHE-1 blocker, inhibited the Na(+)-induced changes in pH(i).	co(2)	22-27	solute carrier family 9 member A1	Rattus norvegicus	145-150
14991407-6	2004	PEPCK also increased in leaves, but not roots or stems, of seedlings grown in an atmosphere containing 5% CO(2), and in roots and stems of seedlings watered with butyric acid.	co(2)	106-111	phosphoenolpyruvate carboxykinase (ATP)	Cucumis sativus	0-5
15204871-3	2004	For the cases studied, we estimate an average CO(2) generation rate per child as 404 mg/min(-1).	co(2)	46-51	CD59 molecule (CD59 blood group)	Homo sapiens	88-94
14758007-5	2004	The E(ES) of COCH(3), CO(2)C(2)H(5) groups is especially originated in the excited dipole moments micro(e).	co(2)	22-27	cochlin	Homo sapiens	13-17
15042349-4	2004	Although its CO(2) sensitivity is low, coexpression of Kir4.1 with Kir5.1 in Xenopus oocytes greatly enhances the CO(2)/pH sensitivities of the heteromeric channels.	co(2)	13-18	potassium inwardly rectifying channel subfamily J member 10 S homeolog	Xenopus laevis	55-61
15042349-4	2004	Although its CO(2) sensitivity is low, coexpression of Kir4.1 with Kir5.1 in Xenopus oocytes greatly enhances the CO(2)/pH sensitivities of the heteromeric channels.	co(2)	114-119	potassium inwardly rectifying channel subfamily J member 10 S homeolog	Xenopus laevis	55-61
15042349-4	2004	Although its CO(2) sensitivity is low, coexpression of Kir4.1 with Kir5.1 in Xenopus oocytes greatly enhances the CO(2)/pH sensitivities of the heteromeric channels.	co(2)	114-119	potassium inwardly rectifying channel subfamily J member 16 S homeolog	Xenopus laevis	67-73
14654398-6	2004	The selenium coated the electrode, hence modifying the surface and consequently the electrochemistry, by causing the "early" appearance of CO(2)-associated IR peaks in SNIFTIRS spectra recorded from the electrode system at potentials lower than those for the Ni/OCN(-) system.	co(2)	139-144	bone gamma-carboxyglutamate protein	Homo sapiens	262-265
16034533-1	2004	The plant-type ferredoxins (Fds) are the [2Fe-2S] proteins that function primarily in photosynthesis; they transfer electrons from photoreduced Photosystem I to ferredoxin NADP(+) reductase in which NADPH is produced for CO(2) assimilation.	co(2)	221-226	ferredoxin reductase	Homo sapiens	161-189
14659984-2	2004	Prompted by clinical reports suggesting that the susceptibility to spontaneous as well as CO(2)-induced anxiety and hyperventilation is attenuated by serotonin reuptake inhibitors (SRIs), we undertook the present study in order to explore the possible effect of an SRI, paroxetine, on baseline respiration and CO(2)-induced hyperventilation in freely moving Wistar rats.	co(2)	90-95	sorcin	Rattus norvegicus	181-184
14659984-2	2004	Prompted by clinical reports suggesting that the susceptibility to spontaneous as well as CO(2)-induced anxiety and hyperventilation is attenuated by serotonin reuptake inhibitors (SRIs), we undertook the present study in order to explore the possible effect of an SRI, paroxetine, on baseline respiration and CO(2)-induced hyperventilation in freely moving Wistar rats.	co(2)	310-315	sorcin	Rattus norvegicus	181-184
16228610-2	2004	The following functions have been proposed for these pathways: adjustment of ATP/NADPH ratio required for CO(2) fixation, generation of the proton gradient for the down-regulation of Photosystem II (PS II), and ATP supply the active transport of inorganic carbon in algal cells.	co(2)	106-111	2,4-dienoyl-CoA reductase 1	Homo sapiens	81-86
15032873-10	2004	When plants are subjected to conditions such as high light, high CO(2), NH(4) (+) nutrition, cold stress, which require changed activities of the enzymes of the malate valves, changed expression levels of the MDH isoforms can be observed.	co(2)	65-70	malic enzyme 1	Homo sapiens	209-212
14644433-6	2003	Indeed, inhibition of the oxidative pentose phosphate pathway by 6-aminonicotinamide abolished the effect of insulin on (14)CO(2) from D-[U-(14)C]glucose.	co(2)	124-129	Insulin-like receptor	Drosophila melanogaster	109-116
14664507-3	2003	The diffusion coefficient of CO(2)-dissolved molecules D was compared with that deduced from the well-known Stokes-Einstein equation and found to significantly deviate from the general trend expected from Stokes-Einstein theory, i.e, D(SE) proportional, variant 1/eta, where D(SE) is the Stokes-Einstein diffusion coefficient and eta the viscosity of the liquid medium.	co(2)	29-34	endothelin receptor type A	Homo sapiens	264-267
14664507-3	2003	The diffusion coefficient of CO(2)-dissolved molecules D was compared with that deduced from the well-known Stokes-Einstein equation and found to significantly deviate from the general trend expected from Stokes-Einstein theory, i.e, D(SE) proportional, variant 1/eta, where D(SE) is the Stokes-Einstein diffusion coefficient and eta the viscosity of the liquid medium.	co(2)	29-34	endothelin receptor type A	Homo sapiens	330-333
14640662-2	2003	The formation of the new C-C bond is shown to take place via oxidative coupling of coordinated CO(2) and C(2)H(4) ligands resulting in a metalla-lactone intermediate, which can rearrange to an agostic species allowing for a beta-hydrogen shift process.	co(2)	95-100	amyloid beta precursor protein	Homo sapiens	222-228
14605215-0	2003	Rubisco activase is required for optimal photosynthesis in the green alga Chlamydomonas reinhardtii in a low-CO(2) atmosphere.	co(2)	109-114	uncharacterized protein	Chlamydomonas reinhardtii	0-16
22063776-6	2003	Although stunning treatment did not influence ultimate pH, muscle lightness, tenderness or cooking loss, drip loss and PSE incidence in LTL muscles from CO(2) stunned pigs were lower compared with ES pigs.	co(2)	153-158	PSE	Sus scrofa	119-122
22063776-8	2003	This research identified that stunning pigs with CO(2) compared with manual ES lowered the incidence of bone fractures, ecchymosis, PSE and drip loss of pork.	co(2)	49-54	PSE	Sus scrofa	132-135
14665508-9	2003	CONCLUSIONS: In norepinephrine-dependent patients in septic shock, continuous infusion of low-dose vasopressin results in a significant increase of the P(g-a)CO(2) gap compatible with GI hypoperfusion.	co(2)	158-163	arginine vasopressin	Homo sapiens	99-110
14579093-5	2003	Hypoxic conditions generated with a mixture of 95% N(2) and 5% CO(2) reduced cellular uptake of the two tracers in both parental MCF7/WT cells and MRP1-expressing MCF7/VP cells.	co(2)	63-68	ATP binding cassette subfamily C member 1	Homo sapiens	147-151
14583137-6	2003	Hypoxia (5% CO(2)/95% N(2)) could markedly increase VEGF protein expression.	co(2)	12-17	vascular endothelial growth factor A	Oryctolagus cuniculus	52-56
14567693-3	2003	Carbonic anhydrase IV (CAIV), which is also present in these tissues, is glycosylphosphatidyl inositol-anchored to the outer surface of the plasma membrane where it catalyzes the hydration-dehydration of CO(2)/HCO(3)(-).	co(2)	204-209	carbonic anhydrase 4	Homo sapiens	0-21
14567693-3	2003	Carbonic anhydrase IV (CAIV), which is also present in these tissues, is glycosylphosphatidyl inositol-anchored to the outer surface of the plasma membrane where it catalyzes the hydration-dehydration of CO(2)/HCO(3)(-).	co(2)	204-209	carbonic anhydrase 4	Homo sapiens	23-27
12950226-2	2003	Reaction of [Co(NH(3))(5)Cl]Cl(2) with PyPS(4)(-) in DMF affords the thiolato-bridged dimeric Co(III) complex (Et(4)N)(2)[Co(2)(PyPS)(2)] (1).	co(2)	122-127	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	97-100
12913167-1	2003	Previous studies of the mitochondrial carbonic anhydrase (mtCA) of Chlamydomonas reinhardtii showed that expression of the two genes encoding this enzyme activity required photosynthetically active radiation and a low CO(2) concentration.	co(2)	218-223	CAH5	Chlamydomonas reinhardtii	24-56
14578124-1	2003	Carbonic anhydrase (CA) is physiologically important in the reversible hydration reaction of CO(2); it is expressed in a number of isoforms (CA I-XIV) with varying degrees of enzymatic activity.	co(2)	93-98	carbonic anhydrase 1	Homo sapiens	141-145
12913181-2	2003	It was initially proposed that this mutant was defective in a carbonic anhydrase (CA) that was a key component of the photosynthetic CO(2)-concentrating mechanism (CCM).	co(2)	133-138	uncharacterized protein	Chlamydomonas reinhardtii	62-80
12913167-1	2003	Previous studies of the mitochondrial carbonic anhydrase (mtCA) of Chlamydomonas reinhardtii showed that expression of the two genes encoding this enzyme activity required photosynthetically active radiation and a low CO(2) concentration.	co(2)	218-223	CAH5	Chlamydomonas reinhardtii	58-62
12913167-3	2003	We have now shown that the expression of the mtCA at low CO(2) concentrations decreases when the external NH(4)(+) concentration decreases, to the point of being undetectable when NH(4)(+) supply restricts the rate of photoautotrophic growth.	co(2)	57-62	CAH5	Chlamydomonas reinhardtii	45-49
12913167-4	2003	The expression of mtCA can also be induced at supra-atmospheric partial pressure of CO(2) by increasing the NH(4)(+) concentration in the growth medium.	co(2)	84-89	CAH5	Chlamydomonas reinhardtii	18-22
12656637-3	2003	On the other hand, stark differences exist in the stability of these molecules as a function of pH and in the presence of CO(2), and also in the types of bond homolysis reactions that PNA and PNI may undergo.	co(2)	122-127	serpin family E member 2	Homo sapiens	192-195
21072616-0	2003	Physiological characteristics of the primitive CO(2) concentrating mechanism in PEPC transgenic rice.	co(2)	47-52	phosphoenolpyruvate carboxylase 1	Zea mays	80-84
21072616-7	2003	Labeling with(14)CO(2) for 20 s showed more(14)C was distributed to C(4) primary photosynthate asperate in PEPC transgenic rice, suggesting that there exists a limiting C(4) photosynthetic mechanism in leaves.	co(2)	17-22	phosphoenolpyruvate carboxylase 1	Zea mays	107-111
12873433-2	2003	Presumably, both acidosis and CO(2) enhance the release of oxygen from hemoglobin.	co(2)	30-35	HGB	Sus scrofa	71-81
12714010-3	2003	This protein is characterized by its ability to interact with anti-insulin antibodies and by mimicking insulin actions as the stimulation of glucose oxidation to CO(2) and lipogenesis in isolated rat adipocytes.	co(2)	162-167	insulin	Homo sapiens	103-110
14681022-1	2003	Cx45 channel sensitivity to CO(2), transjunctional voltage (V(j)) and inhibition of calmodulin (CaM) expression was tested in oocytes by dual voltage-clamp.	co(2)	28-33	gap junction protein gamma 1	Homo sapiens	0-4
14681022-6	2003	This indicates that the speed and sensitivity of V(j)-dependent inactivation of Cx45 channels are increased by CO(2), and that CaM plays a role in gating.	co(2)	111-116	gap junction protein gamma 1	Homo sapiens	80-84
14681022-8	2003	In contrast, sensitivity and speed of V(j) gating of Cx40 and Cx26 channels decreased, rather than increased, with CO(2) application.	co(2)	115-120	gap junction protein alpha 5	Homo sapiens	53-57
14681022-8	2003	In contrast, sensitivity and speed of V(j) gating of Cx40 and Cx26 channels decreased, rather than increased, with CO(2) application.	co(2)	115-120	gap junction protein beta 2	Homo sapiens	62-66
12576408-6	2003	The cerebral vascular reactivity to CO(2) was calculated from the relationship between Pet(CO(2)) and MCAV by using linear regression.	co(2)	36-41	complement C2	Homo sapiens	87-97
12704224-6	2003	Significant inhibition of urethane metabolism to CO(2) occurred in CYP2E1-null versus wild-type mice.	co(2)	49-54	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	67-73
12704224-7	2003	Pharmacokinetic modeling of (14)CO(2) exhalation data revealed that CYP2E1 is responsible for approximately 96% of urethane metabolism to CO(2) in wild-type mice.	co(2)	32-37	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	68-74
12704224-7	2003	Pharmacokinetic modeling of (14)CO(2) exhalation data revealed that CYP2E1 is responsible for approximately 96% of urethane metabolism to CO(2) in wild-type mice.	co(2)	138-143	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	68-74
12686106-1	2003	Dopa decarboxylase (DDC) catalyzes as main reaction the stereospecific CO(2) abstraction from L-Dopa and L-5-hydroxytryptophan (5-HTP), generating the corresponding aromatic amines, dopamine and serotonin, respectively.	co(2)	71-76	dopa decarboxylase	Sus scrofa	0-18
12687366-1	2003	Phosphoenolpyruvate carboxylase (PEPC, EC 4.1.1.31) plays an important role in CO(2) fixation in C4 and CAM plants.	co(2)	79-84	phosphoenolpyruvate carboxylase 2	Triticum aestivum	0-31
12687366-1	2003	Phosphoenolpyruvate carboxylase (PEPC, EC 4.1.1.31) plays an important role in CO(2) fixation in C4 and CAM plants.	co(2)	79-84	phosphoenolpyruvate carboxylase 2	Triticum aestivum	33-37
12388414-8	2003	Although exposure of NBC1-expressing oocytes to CO(2)/HCO(3)(-) resulted in immediate hyperpolarization, the NBC4-expressing oocytes did not show any alteration in membrane potential.	co(2)	48-53	solute carrier family 4 member 4	Rattus norvegicus	21-25
12668769-9	2003	We concluded that FDH has no direct role in the regulation of the above two pathways of Ser synthesis; the breakdown of formate to CO(2) by the FDH reaction is the primary and preferred fate of the organic acid in Arabidopsis.	co(2)	131-136	formate dehydrogenase	Arabidopsis thaliana	144-147
12560116-1	2003	The possible involvement of potassium channels in central chemosensitivity, with special reference to the Kir1.1 potassium channel, was investigated by studying the CO(2) response of presympathetic neurons in the rostroventrolateral medulla (RVLM) in the absence or presence of various K(+) channel inhibitors.	co(2)	165-170	potassium inwardly-rectifying channel, subfamily J, member 1	Rattus norvegicus	106-112
12560116-5	2003	A quantitatively similar inhibition of the central CO(2) response was obtained after administration of 9-fluorenylmethylchloroformate (FMOC-Cl) which eliminates pH sensitivity of Kir1 and Kir4.1.	co(2)	51-56	potassium inwardly-rectifying channel, subfamily J, member 10	Rattus norvegicus	188-194
12531912-8	2003	Inspired CO(2) increased (P < 0.001) the ventilatory response to exercise only below VTh (0.44 +/- 0.10 l x min(-1) x W(-1)).	co(2)	9-14	CD59 molecule (CD59 blood group)	Homo sapiens	111-117
12585900-2	2003	A new carboxylating reagent ((-)CH(2)CN/CO(2)) was obtained by bubbling CO(2) in a CH(3)CN-TEAP (tetraethylammonium perchlorate) solution previously electrolyzed under galvanostatic control.	co(2)	40-45	tumor protein p53 inducible nuclear protein 1	Homo sapiens	91-95
12585900-2	2003	A new carboxylating reagent ((-)CH(2)CN/CO(2)) was obtained by bubbling CO(2) in a CH(3)CN-TEAP (tetraethylammonium perchlorate) solution previously electrolyzed under galvanostatic control.	co(2)	72-77	tumor protein p53 inducible nuclear protein 1	Homo sapiens	91-95
12555229-4	2003	Remarkably, a single conserved LDHA exon 5 haplotype conferred increased risk for a paradoxical ventilatory response pattern to CO(2) inhalation which robustly separated well subjects at high risk for PD from low-risk control subjects.	co(2)	128-133	lactate dehydrogenase A	Homo sapiens	31-35
12555229-6	2003	Given the pivotal role of LDH in the metabolism of lactate, a known inducer of panic attacks, and the dependence of LDH activity on cell pH, we suggest that LDHA polymorphisms may contribute to the variability to CO(2) respiratory challenge.	co(2)	213-218	lactate dehydrogenase A	Homo sapiens	116-119
12555229-6	2003	Given the pivotal role of LDH in the metabolism of lactate, a known inducer of panic attacks, and the dependence of LDH activity on cell pH, we suggest that LDHA polymorphisms may contribute to the variability to CO(2) respiratory challenge.	co(2)	213-218	lactate dehydrogenase A	Homo sapiens	157-161
12554730-7	2003	Increased stomatal densities in sdd1-1 enabled low-light-adapted plants to have 30% higher CO(2) assimilation rates compared to the wild type when exposed to high light intensities.	co(2)	91-96	Subtilase family protein	Arabidopsis thaliana	32-36
12513074-1	2003	Synthetic efforts targeting soluble species of Co(II) with the low molecular mass physiological ligand citric acid led to the isolation of the first dinuclear complex [Co(2)(C(6)H(5)O(7))(2)(H(2)O)(4)](2-), at pH approximately 5, in the form of its K+ (1) and Na+ (2) salts.	co(2)	168-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-53
16228377-4	2003	Acclimation of photosynthesis to high CO(2) occurs in both C(3) and C(4) plants, most notably in nutrient-limited situations.	co(2)	38-43	complement C3	Homo sapiens	59-63
12766360-4	2003	CO(2) reactivity was calculated as percentage change of CBFV (NCR), as absolute change in the concentrations of HbO(2), Hb, and HbT (micromol/l), and as change in TOI (%) per 1% increase in end-tidal CO(2).	co(2)	0-5	Neutrophil migration (granulocyte glycoprotein)	Homo sapiens	62-65
12766360-6	2003	CO(2) reactivity was: NCR left 25.4 +/- 14.7%; NCR right 25.9 +/- 13.4%; HbO(2) 1.99 +/- 0.97 micromol/l; Hb -1.24 +/- 0.81 micromol/l; HbT 0.81 +/- 1.0 micromol/l, and TOI 3.7 +/- 2.2%.	co(2)	0-5	Neutrophil migration (granulocyte glycoprotein)	Homo sapiens	22-25
12766360-6	2003	CO(2) reactivity was: NCR left 25.4 +/- 14.7%; NCR right 25.9 +/- 13.4%; HbO(2) 1.99 +/- 0.97 micromol/l; Hb -1.24 +/- 0.81 micromol/l; HbT 0.81 +/- 1.0 micromol/l, and TOI 3.7 +/- 2.2%.	co(2)	0-5	Neutrophil migration (granulocyte glycoprotein)	Homo sapiens	47-50
16228377-4	2003	Acclimation of photosynthesis to high CO(2) occurs in both C(3) and C(4) plants, most notably in nutrient-limited situations.	co(2)	38-43	complement C4A (Rodgers blood group)	Homo sapiens	68-72
16228369-1	2003	This minireview focuses on the mechanism of inorganic carbon uptake in cyanobacteria and in particular the two CO(2)-uptake systems and two bicarbonate transporters recently identified in Synechocycstis PCC 6803, and their presence in other cyanobacterial strains.	co(2)	111-116	crystallin gamma D	Homo sapiens	203-206
16228376-0	2003	The C(4) pathway: an efficient CO(2) pump.	co(2)	31-36	complement C4A (Rodgers blood group)	Homo sapiens	4-8
16228377-5	2003	High CO(2) aggravates nitrogen limitations and in doing so may favor C(4) species, which have greater photosynthetic nitrogen use efficiency.	co(2)	5-10	complement C4A (Rodgers blood group)	Homo sapiens	69-73
16228376-1	2003	The C(4) pathway is a complex combination of both biochemical and morphological specialisation, which provides an elevation of the CO(2) concentration at the site of Rubisco.	co(2)	131-136	complement C4A (Rodgers blood group)	Homo sapiens	4-8
12509525-5	2003	Compared with wild-type plants, chl1 mutants had reduced stomatal opening and reduced transpiration rates in the light or when deprived of CO(2) in the dark.	co(2)	139-144	cell adhesion molecule L1 like	Homo sapiens	32-36
16228376-2	2003	We review the key parameters necessary to make the C(4) pathway function efficiently, focussing on the diffusion of CO(2) out of the bundle sheath compartment.	co(2)	116-121	complement C4A (Rodgers blood group)	Homo sapiens	51-55
12414042-11	2002	CONCLUSIONS: In contrast to the TMLR- and control group, CO(2)-laser revascularization combined with the application of intramyocardial growth factor, FGF-2, significantly ameliorates perfusion at rest and stress in this model of chronic regional ischemia, whereas sole FGF-2 application showed an improvement at rest only.	co(2)	57-62	fibroblast growth factor 2	Homo sapiens	270-275
16228376-7	2003	Using a mathemathical model of C(4) photosynthesis, we also examine the relationship between bundle sheath resistance to CO(2) diffusion and the biochemical capacity of the C(4) photosynthetic pathway and conclude that bundle sheath resistance to CO(2) diffusion must vary with biochemical capacity if the efficiency of the C(4) pump is to be maintained.	co(2)	121-126	complement C4A (Rodgers blood group)	Homo sapiens	173-177
16228376-7	2003	Using a mathemathical model of C(4) photosynthesis, we also examine the relationship between bundle sheath resistance to CO(2) diffusion and the biochemical capacity of the C(4) photosynthetic pathway and conclude that bundle sheath resistance to CO(2) diffusion must vary with biochemical capacity if the efficiency of the C(4) pump is to be maintained.	co(2)	121-126	complement C4A (Rodgers blood group)	Homo sapiens	173-177
16228376-7	2003	Using a mathemathical model of C(4) photosynthesis, we also examine the relationship between bundle sheath resistance to CO(2) diffusion and the biochemical capacity of the C(4) photosynthetic pathway and conclude that bundle sheath resistance to CO(2) diffusion must vary with biochemical capacity if the efficiency of the C(4) pump is to be maintained.	co(2)	247-252	complement C4A (Rodgers blood group)	Homo sapiens	173-177
16228376-7	2003	Using a mathemathical model of C(4) photosynthesis, we also examine the relationship between bundle sheath resistance to CO(2) diffusion and the biochemical capacity of the C(4) photosynthetic pathway and conclude that bundle sheath resistance to CO(2) diffusion must vary with biochemical capacity if the efficiency of the C(4) pump is to be maintained.	co(2)	247-252	complement C4A (Rodgers blood group)	Homo sapiens	173-177
16228376-8	2003	Finally, we construct a mathematical model of single cell C(4) photosynthesis in a C(3) mesophyll cell and examine the theoretical efficiency of such a C(4) photosynthetic CO(2) pump.	co(2)	172-177	complement C4A (Rodgers blood group)	Homo sapiens	152-156
16228377-3	2003	Rising CO(2) generally stimulates C(3) photosynthesis more than C(4), but C(4) species still exhibit positive responses, particularly at elevated temperature and arid conditions where they are currently common.	co(2)	7-12	complement C3	Homo sapiens	34-38
12482890-8	2002	Taken together, the results indicate that the effects of modulating PKA activity on steady-state pH(i) in rat CA1 neurons under HCO(3)(-)/CO(2)-buffered conditions reflect not only changes in Na(+)-H(+) exchange activity but also changes in Na(+)-dependent and Na(+)-independent Cl(-)-HCO(3)(-) exchange activity that, in turn, may be dependent upon the initial pH(i).	co(2)	138-143	carbonic anhydrase 1	Rattus norvegicus	110-113
12420171-8	2002	Carbon derived from the C-1 of acetyl-CoA contained less (13)C than carbon derived from the C-2 of acetyl-CoA, and this difference was attributed to the acetyl-CoA:CO(2) exchange activity of acetyl-CoA synthase.	co(2)	164-169	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	24-27
12481062-4	2002	The AtAMT2 gene was expressed in all organs of Arabidopsis and was subject to nitrogen (N) regulation, at least in roots where expression was partially repressed by high concentrations of ammonium nitrate and derepressed in the absence of external N. Although expression of AtAMT2 in shoots responded little to changes in root N status, transcript levels in leaves declined under high CO(2) conditions.	co(2)	385-390	ammonium transporter 2	Arabidopsis thaliana	4-10
12467579-1	2002	Phosphoenolpyruvate carboxylase (PEPC) catalyzes the first step in the fixation of atmospheric CO(2) during C(4) photosynthesis.	co(2)	95-100	phosphoenolpyruvate carboxylase 1	Zea mays	33-37
12414101-4	2002	In five healthy volunteers changes in CBF were induced in a randomized order by hyperventilation or inhalation of 6% CO(2).	co(2)	117-122	CCAAT enhancer binding protein zeta	Homo sapiens	38-41
12414101-9	2002	CBF was 51+/-10 in normoventilation, increased by 37% during 6% CO(2) and decreased by 25% during hyperventilation.	co(2)	64-69	CCAAT enhancer binding protein zeta	Homo sapiens	0-3
12391056-5	2002	Alpha(1)-AT-deficient and COPD patients had lower exhaled CO(2) than controls, although only alpha(1)-AT-deficient patients had higher exhaled O(2) than healthy controls.	co(2)	58-63	serpin family A member 1	Homo sapiens	0-11
12239695-0	2002	CO(2) laser endolaryngeal microsurgery with the deflect tip of the pipe-guide handpiece.	co(2)	0-5	TOR signaling pathway regulator	Homo sapiens	56-59
12381821-4	2002	The pH(i) shifts were smaller in the presence of 5 % CO(2)-25 mM HCO(3)(-)-buffered saline (approximately 0.08 pH units in the dendrites and approximately 0.03 pH units in the soma), although a clear spatiotemporal heterogeneity remained.	co(2)	53-58	glucose-6-phosphate isomerase	Rattus norvegicus	4-9
12355213-3	2002	PATIENTS AND METHODS: We determined ODC activity ([(14)C]CO(2) release), polyamines (HPLC), and histological staging and grading (TNM classification) of tissue samples from 64 patients with colorectal adenocarcinomas.	co(2)	57-62	ornithine decarboxylase 1	Homo sapiens	36-39
12379779-1	2002	The consequences of CO(2)-concentrating in leaf air-spaces of CAM plants during daytime organic acid decarboxylation in Phase III of CAM (crassulacean acid metabolism) are explored.	co(2)	20-25	calmodulin 3	Homo sapiens	62-65
12225948-8	2002	Hypoxia (3% O(2)-5% CO(2)-92% N(2)) for 24 h selectively augmented TGF-beta1-stimulated PGE(2) production and COX-2 induction but had no effect alone.	co(2)	20-25	transforming growth factor beta 1	Homo sapiens	67-76
12225948-8	2002	Hypoxia (3% O(2)-5% CO(2)-92% N(2)) for 24 h selectively augmented TGF-beta1-stimulated PGE(2) production and COX-2 induction but had no effect alone.	co(2)	20-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
12239695-2	2002	To improve on this disadvantage, we present a method for CO(2) laser endolaryngeal microsurgery with the deflect tip of the pipe-guide handpiece.	co(2)	57-62	TOR signaling pathway regulator	Homo sapiens	113-116
12239695-4	2002	With the deflect tip of the CO(2) laser pipe-guide handpiece, the laser beam can be irradiated vertical to the laryngeal mucosa, especially in regions such as the inferior surface of the vocal fold and the subglottic mucosa.	co(2)	28-33	TOR signaling pathway regulator	Homo sapiens	17-20
12425850-3	2002	Then the levels of ICAM-1 expressed by fibroblasts incubated with or without CSA in the presence of 10% fetal calf serum for 48 hours at 37 degrees C in 5% CO(2) and air were monitored by using cell-based ELISA for ICAM-1.	co(2)	156-161	intercellular adhesion molecule 1	Homo sapiens	19-25
12183042-8	2002	Since attention deviations have a strong effect on ultra-late LEP amplitude, the subject"s attention should be addressed to CO(2) laser stimuli when ultra-late LEPs are used for clinical purposes.	co(2)	124-129	leptin	Homo sapiens	62-65
12193685-3	2002	Recent studies indicate that selective inhibition of Na(+)/H(+) exchanger type 3 (NHE3) activates CO(2)/H(+)-sensitive neurons, resembling the responses evoked by hypercapnic stimuli.	co(2)	98-103	solute carrier family 9 member A3	Homo sapiens	53-80
12193685-3	2002	Recent studies indicate that selective inhibition of Na(+)/H(+) exchanger type 3 (NHE3) activates CO(2)/H(+)-sensitive neurons, resembling the responses evoked by hypercapnic stimuli.	co(2)	98-103	solute carrier family 9 member A3	Homo sapiens	82-86
12019262-4	2002	With acetate as the sole substrate, 72% of the C-1 and 49% of the C-2 of acetate were released as CO(2); with acetate plus alanine, the corresponding values were decreased to 49 and 25%.	co(2)	98-103	complement C2	Oryctolagus cuniculus	66-69
12093623-0	2002	CO(2)-induced c-Fos expression in brainstem preprotachykinin mRNA containing neurons.	co(2)	0-5	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-19
12073947-4	2002	The P(a)CO(2) was increased only at 1 min.	co(2)	8-13	angiotensin II receptor type 1	Homo sapiens	33-37
12060729-6	2002	Numerical simulations with a global biogeochemical carbon cycle model indicate that CO(2) outgassing during the eruption of the Deccan Trap basalts fails to fully account for the inferred pCO(2) increase.	co(2)	84-89	TRAP	Homo sapiens	135-139
12031901-7	2002	The detection of glyoxylic acid and CO(2)(-*) from Asp demonstrates the occurrence of competing beta-scission processes for the Asp C-3 alkoxyl radical.	co(2)	36-41	complement C3	Homo sapiens	132-135
12093623-3	2002	Experiments were performed in 21-day-old rats exposed to 12% CO(2) for 1 h. c-Fos expression was identified by IHH on free floating sections (40 microm) that were mounted and then hybridized with anti-sense 35S labeled ribonucleotide probe of the rat preprotachykinin A (PPT-A) gene.	co(2)	61-66	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	76-81
11863462-1	2002	The maximal velocity of catalysis of CO(2) hydration by human carbonic anhydrase II (HCA II) requires proton transfer from zinc-bound water to solution assisted by His 64.	co(2)	37-42	carbonic anhydrase 2	Homo sapiens	62-83
11886890-8	2002	Expression of a single gene from maize, NADP-malic enzyme (ME), which converts malate and NADP to pyruvate, NADPH, and CO(2), resulted in altered stomatal behaviour and water relations in tobacco.	co(2)	119-124	NADP-dependent malic enzyme	Zea mays	40-57
11886890-8	2002	Expression of a single gene from maize, NADP-malic enzyme (ME), which converts malate and NADP to pyruvate, NADPH, and CO(2), resulted in altered stomatal behaviour and water relations in tobacco.	co(2)	119-124	NADP-dependent malic enzyme	Zea mays	59-61
11863953-0	2002	Symmetry-resolved vibrational spectroscopy for the C 1s(-1)2 pi(u) Renner-Teller pair states in CO(2).	co(2)	96-101	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	51-54
11842068-0	2002	Differential CO(2)-induced c-fos gene expression in the nucleus tractus solitarii of inbred mouse strains.	co(2)	13-18	FBJ osteosarcoma oncogene	Mus musculus	27-32
11842068-7	2002	CO(2)-induced increase in c-fos gene expression was significantly (P < 0.01) greater in NTS regions of B6 compared with C3 mice.	co(2)	0-5	FBJ osteosarcoma oncogene	Mus musculus	26-31
11842068-7	2002	CO(2)-induced increase in c-fos gene expression was significantly (P < 0.01) greater in NTS regions of B6 compared with C3 mice.	co(2)	0-5	complement component 3	Mus musculus	123-125
11735412-8	2001	Both the scavenging and the isomerization activities of metHb were heme-dependent and inhibited by CO(2).	co(2)	99-104	hemoglobin subunit gamma 2	Homo sapiens	56-61
11827525-1	2002	CO dehydrogenase/acetyl-CoA synthase (CODH/ACS), a key enzyme in the Wood-Ljungdahl pathway of anaerobic CO(2) fixation, is a bifunctional enzyme containing CODH, which catalyzes the reversible two-electron oxidation of CO to CO(2), and ACS, which catalyzes acetyl-CoA synthesis from CoA, CO, and a methylated corrinoid iron-sulfur protein (CFeSP).	co(2)	105-110	acyl-CoA synthetase short chain family member 2	Homo sapiens	38-46
11827525-1	2002	CO dehydrogenase/acetyl-CoA synthase (CODH/ACS), a key enzyme in the Wood-Ljungdahl pathway of anaerobic CO(2) fixation, is a bifunctional enzyme containing CODH, which catalyzes the reversible two-electron oxidation of CO to CO(2), and ACS, which catalyzes acetyl-CoA synthesis from CoA, CO, and a methylated corrinoid iron-sulfur protein (CFeSP).	co(2)	105-110	acyl-CoA synthetase short chain family member 2	Homo sapiens	43-46
11827525-1	2002	CO dehydrogenase/acetyl-CoA synthase (CODH/ACS), a key enzyme in the Wood-Ljungdahl pathway of anaerobic CO(2) fixation, is a bifunctional enzyme containing CODH, which catalyzes the reversible two-electron oxidation of CO to CO(2), and ACS, which catalyzes acetyl-CoA synthesis from CoA, CO, and a methylated corrinoid iron-sulfur protein (CFeSP).	co(2)	226-231	acyl-CoA synthetase short chain family member 2	Homo sapiens	38-46
11827525-1	2002	CO dehydrogenase/acetyl-CoA synthase (CODH/ACS), a key enzyme in the Wood-Ljungdahl pathway of anaerobic CO(2) fixation, is a bifunctional enzyme containing CODH, which catalyzes the reversible two-electron oxidation of CO to CO(2), and ACS, which catalyzes acetyl-CoA synthesis from CoA, CO, and a methylated corrinoid iron-sulfur protein (CFeSP).	co(2)	226-231	acyl-CoA synthetase short chain family member 2	Homo sapiens	43-46
11788132-0	2002	CO(2)-induced c-Fos expression in hypothalamic vasopressin containing neurons.	co(2)	0-5	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-19
11788132-0	2002	CO(2)-induced c-Fos expression in hypothalamic vasopressin containing neurons.	co(2)	0-5	arginine vasopressin	Rattus norvegicus	47-58
11788132-4	2002	A marked increase in c-Fos positive cells was induced after 2 h of breathing a gas mixture with elevated CO(2) (5% CO(2), 21% O(2) and 74% N(2), or 1 h following breathing of 12% CO(2,) 21% O(2,) and 67% N(2)).	co(2)	105-110	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	21-26
11788132-4	2002	A marked increase in c-Fos positive cells was induced after 2 h of breathing a gas mixture with elevated CO(2) (5% CO(2), 21% O(2) and 74% N(2), or 1 h following breathing of 12% CO(2,) 21% O(2,) and 67% N(2)).	co(2)	115-120	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	21-26
11738649-0	2001	Localization of connexin26 and connexin32 in putative CO(2)-chemosensitive brainstem regions in rat.	co(2)	54-59	gap junction protein, beta 1	Rattus norvegicus	31-41
11735541-4	2001	In contrast, cis-1,4-bis(triphenylsilylethynyl)cyclohexane-1,4-diol reacts with Co(2)(CO)(8) to yield the twist-boat conformer in which the two axial hydroxy substituents exhibit intra-molecular hydrogen bonding.	co(2)	80-85	suppressor of cytokine signaling 1	Homo sapiens	13-18
11735541-5	2001	Likewise, the corresponding reaction of cis-1,4-bis(trimethylsilylethynyl)cyclohexane-1,4-diol with Co(2)(CO)(8) leads to a twist-boat, but in this case, the molecules are linked through inter-molecular hydrogen bonds.	co(2)	100-105	suppressor of cytokine signaling 1	Homo sapiens	40-45
11738645-5	2001	A similar pattern of pH(i) response is seen in other CO(2)/H(+)-responsive cells, including glomus cells, sour taste receptor cells, and chemosensitive neurons from snails, suggesting that a maintained fall of pH(i) is a common feature of the proximal signal in all CO(2)/H(+)-sensitive cells.	co(2)	53-58	glucose-6-phosphate isomerase 1	Mus musculus	21-26
11738645-5	2001	A similar pattern of pH(i) response is seen in other CO(2)/H(+)-responsive cells, including glomus cells, sour taste receptor cells, and chemosensitive neurons from snails, suggesting that a maintained fall of pH(i) is a common feature of the proximal signal in all CO(2)/H(+)-sensitive cells.	co(2)	266-271	glucose-6-phosphate isomerase 1	Mus musculus	21-26
11738645-5	2001	A similar pattern of pH(i) response is seen in other CO(2)/H(+)-responsive cells, including glomus cells, sour taste receptor cells, and chemosensitive neurons from snails, suggesting that a maintained fall of pH(i) is a common feature of the proximal signal in all CO(2)/H(+)-sensitive cells.	co(2)	266-271	glucose-6-phosphate isomerase 1	Mus musculus	210-215
11738649-2	2001	Here, we used immunoblot and immunohistochemical analyses to investigate the presence, distribution, and cellular localization of the gap junction proteins connexin26 (Cx26) and connexin32 (Cx32) in putative CO(2)-chemosensitive brainstem regions in both neonatal and adult rats.	co(2)	208-213	gap junction protein, beta 2	Rattus norvegicus	156-166
11738649-0	2001	Localization of connexin26 and connexin32 in putative CO(2)-chemosensitive brainstem regions in rat.	co(2)	54-59	gap junction protein, beta 2	Rattus norvegicus	16-26
11738649-2	2001	Here, we used immunoblot and immunohistochemical analyses to investigate the presence, distribution, and cellular localization of the gap junction proteins connexin26 (Cx26) and connexin32 (Cx32) in putative CO(2)-chemosensitive brainstem regions in both neonatal and adult rats.	co(2)	208-213	gap junction protein, beta 2	Rattus norvegicus	168-172
11738649-2	2001	Here, we used immunoblot and immunohistochemical analyses to investigate the presence, distribution, and cellular localization of the gap junction proteins connexin26 (Cx26) and connexin32 (Cx32) in putative CO(2)-chemosensitive brainstem regions in both neonatal and adult rats.	co(2)	208-213	gap junction protein, beta 1	Rattus norvegicus	178-188
11738649-2	2001	Here, we used immunoblot and immunohistochemical analyses to investigate the presence, distribution, and cellular localization of the gap junction proteins connexin26 (Cx26) and connexin32 (Cx32) in putative CO(2)-chemosensitive brainstem regions in both neonatal and adult rats.	co(2)	208-213	gap junction protein, beta 1	Rattus norvegicus	190-194
11738649-4	2001	Immunohistochemical experiments confirmed Cx expression in each of the putative CO(2)-chemosensitive brainstem regions, and further demonstrated that Cx26 and Cx32 were found in neurons and Cx26 was also found in astrocytes in these regions.	co(2)	80-85	gap junction protein, beta 1	Rattus norvegicus	159-163
11738649-6	2001	We propose that the gap junction proteins Cx26 and Cx32, at least in part, form the neuroanatomical substrate for this gap junctional communication, which is hypothesized to play a role in central CO(2) chemoreception.	co(2)	197-202	gap junction protein, beta 2	Rattus norvegicus	42-46
11738649-6	2001	We propose that the gap junction proteins Cx26 and Cx32, at least in part, form the neuroanatomical substrate for this gap junctional communication, which is hypothesized to play a role in central CO(2) chemoreception.	co(2)	197-202	gap junction protein, beta 1	Rattus norvegicus	51-55
11738651-6	2001	The inward rectifier K(+) channels (Kir) seem to be some of the CO(2) sensing molecules, as they regulate membrane potential and cell excitability and are pH sensitive.	co(2)	64-69	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	36-39
11738651-10	2001	In current clamp, we show evidence that the Kir4.1-Kir5.1 can detect P(CO(2)) changes in either hypercapnic or hypocapnic direction.	co(2)	71-76	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	44-50
11738651-10	2001	In current clamp, we show evidence that the Kir4.1-Kir5.1 can detect P(CO(2)) changes in either hypercapnic or hypocapnic direction.	co(2)	71-76	potassium inwardly rectifying channel subfamily J member 16	Homo sapiens	51-57
11738651-12	2001	Thus, it is likely that the heteromeric Kir4.1-Kir5.1 contributes to the CO(2)/pH sensitivity in these neurons.	co(2)	73-78	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	40-46
11738651-12	2001	Thus, it is likely that the heteromeric Kir4.1-Kir5.1 contributes to the CO(2)/pH sensitivity in these neurons.	co(2)	73-78	potassium inwardly rectifying channel subfamily J member 16	Homo sapiens	47-53
11568155-6	2001	Histochemical and immunocytochemical data showed that the right FNr contained clustered HRP-labeled neurons, most of which were double labeled with c-Fos immunoreactivity in both electrically and CO(2)-stimulated rats.	co(2)	196-201	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	148-153
11711580-10	2001	End-tidal P(CO2) was maintained by increasing the inspired CO(2) fraction (F(I,CO2)) as needed.	co(2)	59-64	complement C2	Homo sapiens	10-15
11681893-1	2001	The electro-oxidation of cobalt (II) octaethylporphyrin adsorbed on graphite electrodes, Co(II)(OEP)(ads") to Co(III)(OEP)(ads)(+), in the presence of aqueous solutions of CO leads to catalytic oxidation of CO to CO(2).	co(2)	213-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-95
11681893-1	2001	The electro-oxidation of cobalt (II) octaethylporphyrin adsorbed on graphite electrodes, Co(II)(OEP)(ads") to Co(III)(OEP)(ads)(+), in the presence of aqueous solutions of CO leads to catalytic oxidation of CO to CO(2).	co(2)	213-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-99
11598234-6	2001	These mutants are likely to be defective in some aspects of the acclimation to low CO(2) because they differ from wild type in their growth and in the expression patterns of five low CO(2)-inducible genes (Cah1, Mca1, Mca2, Ccp1, and Ccp2).	co(2)	83-88	uncharacterized protein	Chlamydomonas reinhardtii	212-216
19002908-3	2001	Interestingly, the production of EPO in the culture incubated under no CO(2) supply was highest among the tested cultures.	co(2)	71-76	erythropoietin	Cricetulus griseus	33-36
19002908-4	2001	The cell specific secretion rate of EPO (q(EPO)) of the culture under no CO(2) supply was about 3 times higher than that of the culture under 5% CO(2) supply.	co(2)	73-78	erythropoietin	Cricetulus griseus	36-39
19002908-4	2001	The cell specific secretion rate of EPO (q(EPO)) of the culture under no CO(2) supply was about 3 times higher than that of the culture under 5% CO(2) supply.	co(2)	145-150	erythropoietin	Cricetulus griseus	36-39
19002908-9	2001	However, the q(EPO) of the no CO(2) supply case was more than 5 times higher than that of the culture under 5% CO(2) supply.	co(2)	30-35	erythropoietin	Cricetulus griseus	15-18
19002908-9	2001	However, the q(EPO) of the no CO(2) supply case was more than 5 times higher than that of the culture under 5% CO(2) supply.	co(2)	111-116	erythropoietin	Cricetulus griseus	15-18
19002908-10	2001	In conclusion, we have demonstrated that a simple programming of CO(2) supply to an incubator can enhance the production of EPO in CHO cells remarkably, without any apparent change of the EPO quality.	co(2)	65-70	erythropoietin	Cricetulus griseus	124-127
11598234-6	2001	These mutants are likely to be defective in some aspects of the acclimation to low CO(2) because they differ from wild type in their growth and in the expression patterns of five low CO(2)-inducible genes (Cah1, Mca1, Mca2, Ccp1, and Ccp2).	co(2)	183-188	uncharacterized protein	Chlamydomonas reinhardtii	212-216
11556805-1	2001	NEUT2 mice are deficient in cytosolic 10-formyltetrahydrofolate dehydrogenase (FDH; EC 1.5.1.6) which catalyzes the oxidation of excess folate-linked one-carbon units in the form of 10-formyltetrahydrofolate to CO(2) and tetrahydrofolate (Champion et al., Proc.	co(2)	211-216	aldehyde dehydrogenase 1 family, member L1	Mus musculus	0-5
11673625-5	2001	The ribulose bisphosphate carboxylase (RuBPcase) content and activation ratio in the high-CO(2) leaves remained high and roughly constant during the experiment, and were unchanged by the exposure, while this enzyme was slightly inactivated or inhibited after long-term exposure to CO(2) enrichment.	co(2)	90-95	ribulose bisphosphate carboxylase small subunit, chloroplastic 1	Glycine max	4-37
11673625-5	2001	The ribulose bisphosphate carboxylase (RuBPcase) content and activation ratio in the high-CO(2) leaves remained high and roughly constant during the experiment, and were unchanged by the exposure, while this enzyme was slightly inactivated or inhibited after long-term exposure to CO(2) enrichment.	co(2)	90-95	ribulose bisphosphate carboxylase small subunit, chloroplastic 1	Glycine max	39-47
11673625-5	2001	The ribulose bisphosphate carboxylase (RuBPcase) content and activation ratio in the high-CO(2) leaves remained high and roughly constant during the experiment, and were unchanged by the exposure, while this enzyme was slightly inactivated or inhibited after long-term exposure to CO(2) enrichment.	co(2)	281-286	ribulose bisphosphate carboxylase small subunit, chloroplastic 1	Glycine max	4-37
11673625-5	2001	The ribulose bisphosphate carboxylase (RuBPcase) content and activation ratio in the high-CO(2) leaves remained high and roughly constant during the experiment, and were unchanged by the exposure, while this enzyme was slightly inactivated or inhibited after long-term exposure to CO(2) enrichment.	co(2)	281-286	ribulose bisphosphate carboxylase small subunit, chloroplastic 1	Glycine max	39-47
11673625-7	2001	It is consequently concluded that, during the acclimation to CO(2 )enrichment, the suppression of photosynthesis through end-product inhibition was mainly caused by a lowering of the carboxylation efficiency of RuBPcase due to hindrance of CO(2) diffusion from the intercellular space to the stroma in chloroplasts brought about by the large accumulation of starch.	co(2)	240-245	ribulose bisphosphate carboxylase small subunit, chloroplastic 1	Glycine max	211-219
11556805-12	2001	These results indicate that mice are able to oxidize formate to CO(2) by at least three different routes: (1) folate-dependent via FDH at low levels of formate; (2) peroxidation by catalase at high levels of formate; and (3) by an unknown route(s) which appears to function at both low and high levels of formate.	co(2)	64-69	aldehyde dehydrogenase 1 family, member L1	Mus musculus	131-134
11556805-1	2001	NEUT2 mice are deficient in cytosolic 10-formyltetrahydrofolate dehydrogenase (FDH; EC 1.5.1.6) which catalyzes the oxidation of excess folate-linked one-carbon units in the form of 10-formyltetrahydrofolate to CO(2) and tetrahydrofolate (Champion et al., Proc.	co(2)	211-216	aldehyde dehydrogenase 1 family, member L1	Mus musculus	28-77
11556805-1	2001	NEUT2 mice are deficient in cytosolic 10-formyltetrahydrofolate dehydrogenase (FDH; EC 1.5.1.6) which catalyzes the oxidation of excess folate-linked one-carbon units in the form of 10-formyltetrahydrofolate to CO(2) and tetrahydrofolate (Champion et al., Proc.	co(2)	211-216	aldehyde dehydrogenase 1 family, member L1	Mus musculus	79-82
11531445-3	2001	The volume of activation for the reaction (hedta)Fe(III)-CO(2)(2-) + CO(2)(*-) + 2H(+) --> Fe(II)(hedta)(H(2)O)(-) + CO + CO(2) was measured, and the results enable a tentative proposal for the nature of the transition state of this interesting reaction.	co(2)	57-62	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	52-55
11531445-3	2001	The volume of activation for the reaction (hedta)Fe(III)-CO(2)(2-) + CO(2)(*-) + 2H(+) --> Fe(II)(hedta)(H(2)O)(-) + CO + CO(2) was measured, and the results enable a tentative proposal for the nature of the transition state of this interesting reaction.	co(2)	69-74	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	52-55
11226232-1	2001	The chloroplast gene rbcL encodes the large subunit of the CO(2)-fixing enzyme ribulose-bisphosphate carboxylase.	co(2)	59-64	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit	Chlamydomonas reinhardtii	21-25
18360475-1	2001	We report examples of the use of a scanning tunable CO(2) laser lidar system in the 9-11-mum region to construct images of vegetation and rocks at ranges as far as 5 km from the instrument.	co(2)	52-57	latexin	Homo sapiens	89-92
11463601-7	2001	Furthermore, the serum ST2 levels during asthma exacerbation statistically correlated with the percentage of predicted peak expiratory flow (r = -0.634, p = 0.004) and Pa(CO(2)) (r = 0.516, p = 0.003).	co(2)	171-176	ST2	Homo sapiens	23-26
11423402-5	2001	Both Cx43 and Cx43-EGFP channels exhibit slow gating by chemical uncouplers such as CO(2) and alkanols.	co(2)	84-89	gap junction protein alpha 1	Homo sapiens	5-9
11423402-5	2001	Both Cx43 and Cx43-EGFP channels exhibit slow gating by chemical uncouplers such as CO(2) and alkanols.	co(2)	84-89	gap junction protein alpha 1	Homo sapiens	14-18
11414818-1	2001	Catalysis of (18)O exchange between CO(2) and water catalyzed by a Co(II)-substituted mutant of human carbonic anhydrase II is analyzed to show the rate of release of H(2)(18)O from the active site.	co(2)	36-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
11414818-1	2001	Catalysis of (18)O exchange between CO(2) and water catalyzed by a Co(II)-substituted mutant of human carbonic anhydrase II is analyzed to show the rate of release of H(2)(18)O from the active site.	co(2)	36-41	carbonic anhydrase 2	Homo sapiens	102-123
11410011-3	2001	Oxidation of pyrogallol red, liposomes, and microsomes initiated by peroxynitrite continuously produced by 3-morpholinosydnonimine (SIN-1, 2 mM) was time-dependent and enhanced by CO(2) (1 mM).	co(2)	180-185	MAPK associated protein 1	Homo sapiens	132-137
11595062-2	2001	We have already shown that expired (14)CO(2) after oral administration of (14)C-putrescine correlated with intestinal DAO activity.	co(2)	39-44	amine oxidase, copper containing 1	Rattus norvegicus	118-121
11595062-13	2001	CONCLUSIONS: Our studies suggested that expired (14)CO(2) after oral administration of (14)C-putrescine correlates with mucosal DAO activity, and that it also reflects intestinal function.	co(2)	52-57	amine oxidase, copper containing 1	Rattus norvegicus	128-131
11498317-16	2001	P(ET)CO(2)increased from 29.5 to 36 mmHg at an IAP of 15 mmHg, but then no further changes were noticed.	co(2)	5-10	alkaline phosphatase, intestinal	Homo sapiens	47-50
11435462-6	2001	In addition, up to 80% of amiloride-insensitive pH(i) recovery from acid load in the presence of HCO(3)(-)/CO(2) was inhibited by adenovirus-mediated transfer of a specific hammerhead ribozyme against NBC-1, consistent with a major role of NBC-1 in overall HCO(3)-transport by the lens epithelium.	co(2)	107-112	solute carrier family 4 member 4	Homo sapiens	201-206
11435462-6	2001	In addition, up to 80% of amiloride-insensitive pH(i) recovery from acid load in the presence of HCO(3)(-)/CO(2) was inhibited by adenovirus-mediated transfer of a specific hammerhead ribozyme against NBC-1, consistent with a major role of NBC-1 in overall HCO(3)-transport by the lens epithelium.	co(2)	107-112	solute carrier family 4 member 4	Homo sapiens	240-245
18357269-0	2001	Absolute Intensities and Pressure-Broadening Coefficients of 2-mum CO(2) Absorption Features: Intracavity Laser Spectroscopy.	co(2)	67-72	latexin	Homo sapiens	63-66
18357269-3	2001	band (12 degrees 1-00 degrees 0) of CO(2) (at 2.0129, 2.0136, and 2.0143 mum) are measured quantitatively by ILS with a Tm:YAG laser operating near 2.0 mum.	co(2)	36-41	latexin	Homo sapiens	73-76
11353022-5	2001	Hypocapnia from 5 to 1% CO(2) led to a stable monophasic increase of 0.5 and 0.2 units in pH(o) and pH(i), respectively.	co(2)	24-29	glucose-6-phosphate isomerase	Rattus norvegicus	100-105
11327835-1	2001	Histidine 64 in human carbonic anhydrase II (HCA II) functions in the catalytic pathway of CO(2) hydration as a shuttle to transfer protons between the zinc-bound water and bulk water.	co(2)	91-96	carbonic anhydrase 2	Homo sapiens	22-43
11157876-0	2001	Effect of AQP1 expression level on Co(2) permeability in bovine corneal endothelium.	co(2)	35-40	aquaporin 1	Bos taurus	10-14
11456660-4	2001	P-1[Co(II)] has a significantly higher affinity for NO compared to O(2), CO(2), and CO.	co(2)	73-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
11157876-2	2001	CO(2) permeability (P:CO(2)) measurements in an oocyte expression system and in reconstituted proteoliposomes have suggested that the water channel AQP1 can transport CO(2).	co(2)	0-5	aquaporin 1	Bos taurus	148-152
11157876-2	2001	CO(2) permeability (P:CO(2)) measurements in an oocyte expression system and in reconstituted proteoliposomes have suggested that the water channel AQP1 can transport CO(2).	co(2)	22-27	aquaporin 1	Bos taurus	148-152
11121027-5	2000	The catalysis of CO(2) hydration by soluble CA XII has a maximal value of k(cat)/K(m) at 34 microM(-1) small middle dots(-1), which is similar to those of the membrane-associated CA IV and to soluble CA I.	co(2)	17-22	carbonic anhydrase 12	Homo sapiens	44-50
11024031-1	2001	Glutaryl-CoA dehydrogenase catalyzes the oxidation and decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2).	co(2)	107-112	glutaryl-CoA dehydrogenase	Homo sapiens	0-26
16228304-10	2001	I added inhibitors of glycolate oxidase to leaves and showed: (1) glycolate was synthesized only in light as an early product of photosynthetic CO(2) assimilation, (2) the rate of glycolate oxidation consumed a sizable fraction of net photosynthesis in C(3) but not in C(4) plants, and (3) that glycolate metabolism increased greatly at higher temperatures.	co(2)	144-149	hydroxyacid oxidase 2	Homo sapiens	22-39
11150070-8	2001	The recurrence rate after CO(2) laser cordectomy was 16.6% for LIN 2 and 18.7% for LIN 3.	co(2)	26-31	calcium/calmodulin dependent serine protein kinase	Homo sapiens	63-68
11121027-8	2000	The catalytic rate of CO(2) hydration by the soluble form of CA XII is identical with that of the membrane-bound enzyme.	co(2)	22-27	carbonic anhydrase 12	Homo sapiens	61-67
11121027-9	2000	These observations suggest a role for CA XII in CO(2)/HCO(3)(-) homeostasis in cells in which it is normally expressed.	co(2)	48-53	carbonic anhydrase 12	Homo sapiens	38-44
11121027-5	2000	The catalysis of CO(2) hydration by soluble CA XII has a maximal value of k(cat)/K(m) at 34 microM(-1) small middle dots(-1), which is similar to those of the membrane-associated CA IV and to soluble CA I.	co(2)	17-22	carbonic anhydrase 4	Homo sapiens	179-184
11121027-5	2000	The catalysis of CO(2) hydration by soluble CA XII has a maximal value of k(cat)/K(m) at 34 microM(-1) small middle dots(-1), which is similar to those of the membrane-associated CA IV and to soluble CA I.	co(2)	17-22	carbonic anhydrase 1	Homo sapiens	179-183
11113841-7	2000	CONCLUSION: The development of POF in females with galactosemia is more likely if the patient"s genotype is Q188R/Q188R, if the mean erythrocyte Gal-1-P is >3.5 mg/dL during therapy, and if the recovery of (13)CO(2) from whole-body (13)C-galactose oxidation is reduced below 5% of administered (13)C-galactose.	co(2)	213-218	POF1B actin binding protein	Homo sapiens	31-34
11093925-1	2000	Acyl-CoA synthetase (ACS) catalyzes the activation of long-chain fatty acids to acyl-CoAs, which can be metabolized to form CO(2), triacylglycerol (TAG), phospholipids (PL), and cholesteryl esters (CE).	co(2)	124-129	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	0-19
11093925-1	2000	Acyl-CoA synthetase (ACS) catalyzes the activation of long-chain fatty acids to acyl-CoAs, which can be metabolized to form CO(2), triacylglycerol (TAG), phospholipids (PL), and cholesteryl esters (CE).	co(2)	124-129	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	21-24
11110772-3	2000	Ventilation of pigs with 6% CO(2) (PaCO(2 approximately)65 mm Hg; pH approximately 7.2) caused a approximately 2.5-fold increase in CBF at 30 minutes, which declined to basal values at 3 hours and gradually rose again at 6 and 8 hours; the latter increase was associated with PG elevation, nitrite formation, eNOS mRNA expression, and in situ NO synthase (NOS) reactivity (NADPH-diaphorase staining).	co(2)	28-33	nitric oxide synthase 3	Sus scrofa	343-354
11029294-12	2000	Combined mutations of the lysine and histidine residues in Kir4.1 (K53V/S328H/G340H) gave rise to a channel that had CO(2)/pH sensitivities almost identical to those of the wild-type Kir1.1.	co(2)	117-122	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	59-65
11029294-8	2000	Reverse mutation on Kir1.1 (V66K) decreased the CO(2)/pH sensitivities.	co(2)	48-53	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	20-26
11029294-12	2000	Combined mutations of the lysine and histidine residues in Kir4.1 (K53V/S328H/G340H) gave rise to a channel that had CO(2)/pH sensitivities almost identical to those of the wild-type Kir1.1.	co(2)	117-122	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	183-189
11029294-11	2000	Mutation of two of these histidine residues in Kir1.1 (H342Q/H354N) reduced CO(2)/pH sensitivities, whereas the creation of two histidines (S328H/G340H) in Kir4.1 increased the CO(2)/pH sensitivities.	co(2)	76-81	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	47-53
11027616-6	2000	Phe(P)(OPh)-(CH(2))(2)-CO(2)Et inactivates cathepsin G approximately 45-fold more rapidly (k(i)/K(i) = 1.2 x 10(5) M(-1).	co(2)	23-28	cathepsin G	Homo sapiens	43-54
11029294-11	2000	Mutation of two of these histidine residues in Kir1.1 (H342Q/H354N) reduced CO(2)/pH sensitivities, whereas the creation of two histidines (S328H/G340H) in Kir4.1 increased the CO(2)/pH sensitivities.	co(2)	177-182	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	47-53
11052958-3	2000	Palmitate oxidation, which is at least partially dependent on carnitine palmitoyltransferase-1 (CPT-1) activity, was depressed (P < 0.05) by approximately 50% with obesity (6.8 +/- 2.2 vs. 13.7 +/- 1.4 nmole CO(2).g(-1).h(-1)).	co(2)	211-216	carnitine palmitoyltransferase 1A	Homo sapiens	96-101
11067971-1	2000	High-voltage-activated calcium currents (HVA) of CA1 neurons are prominently attenuated following a switch from HEPES-buffered solution to one buffered with CO(2)/HCO(3)(-).	co(2)	157-162	carbonic anhydrase 1	Homo sapiens	49-52
11067990-1	2000	The effect of HCO(3)(-)/CO(2) on membrane properties of isolated hippocampal CA1 neurons was studied with the use of the whole cell configuration of the patch-clamp technique.	co(2)	24-29	carbonic anhydrase 1	Mus musculus	77-80
11067990-3	2000	In the current-clamp mode, HCO(3)(-)/CO(2) significantly hyperpolarized CA1 neurons by more than 10 mV and decreased their input resistance.	co(2)	37-42	carbonic anhydrase 1	Mus musculus	72-75
11067990-8	2000	We conclude that HCO(3)(-)/CO(2) decreases the intrinsic excitability of CA1 neurons by altering not only the passive properties of the neuronal membranes but also by changing several characteristics of the fast Na(+) current, including activation and inactivation kinetics as well as the recovery from inactivation and deactivation.	co(2)	27-32	carbonic anhydrase 1	Mus musculus	73-76
11116419-5	2000	Therefore, we set out to investigate intracytoplasmic changes in vimentin and actin after a 4-h CO(2) pneumoperitoneum in the head-down position in rabbits with alpha-chymotrypsin-induced glaucoma.	co(2)	96-101	vimentin	Oryctolagus cuniculus	65-73
11027616-9	2000	Similarly, Cbz.Val(P)(OPh)-(CH(2))(2)-CO(2)Et was found to inactivate HNE some 3-fold more efficiently than Cbz.Val(P)(OPh)(2) (6.5 x 10(3) and 2.0 x 10(3) M(-1).	co(2)	38-43	elastase, neutrophil expressed	Homo sapiens	70-73
10996193-0	2000	Influence of longterm CPAP therapy on CO(2) drive in patients with obstructive sleep apnea.	co(2)	38-43	centromere protein J	Homo sapiens	22-26
10999959-7	2000	Nevertheless, the rate of (14)CO(2) appearance in the breath showed no relationship with these measurements of CYP3A, but changed proportionally to expression of mdr1.	co(2)	30-35	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	162-166
10999959-8	2000	The average breath test (14)CO(2) area under the curves were 1.9- and 1.5-fold greater in mdr1a/1b(-/-) and mdr1a(-/-) mice, respectively, compared with (+/+) mice, and CER(max) was 2-fold greater in mdr1a/1b(-/-) compared with (+/+) mice.	co(2)	28-33	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	90-95
10999959-8	2000	The average breath test (14)CO(2) area under the curves were 1.9- and 1.5-fold greater in mdr1a/1b(-/-) and mdr1a(-/-) mice, respectively, compared with (+/+) mice, and CER(max) was 2-fold greater in mdr1a/1b(-/-) compared with (+/+) mice.	co(2)	28-33	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	108-113
10999959-8	2000	The average breath test (14)CO(2) area under the curves were 1.9- and 1.5-fold greater in mdr1a/1b(-/-) and mdr1a(-/-) mice, respectively, compared with (+/+) mice, and CER(max) was 2-fold greater in mdr1a/1b(-/-) compared with (+/+) mice.	co(2)	28-33	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	108-113
10996193-7	2000	Therefore, we evaluated the effect of 1 year CPAP therapy on CO(2) drive in 20 OSA patients.	co(2)	61-66	centromere protein J	Homo sapiens	45-49
10996193-10	2000	We conclude that CPAP therapy improves daytime gas exchange in normocapnic OSA and may possibly decrease CO(2) drive (slope) after a treatment period of 1 year.	co(2)	105-110	centromere protein J	Homo sapiens	17-21
10644552-1	2000	L-2-oxothiazolidine-4-carboxylic acid (OTZ), a 5-oxoproline analog, is metabolized by 5-oxoprolinase and converted to cysteine, the rate-limiting amino acid for GSH synthesis, with the release of CO(2).	co(2)	196-201	5-oxoprolinase, ATP-hydrolysing	Homo sapiens	86-100
10985795-1	2000	Glutaryl-CoA dehydrogenase catalyzes the oxidation of glutaryl-CoA to crotonyl-CoA and CO(2) in the mitochondrial degradation of lysine, hydroxylysine, and tryptophan.	co(2)	87-92	glutaryl-CoA dehydrogenase	Homo sapiens	0-26
10836977-1	2000	Carbonic anhydrase (CA) IV is a membrane-bound enzyme that catalyzes the dehydration of carbonic acid to CO(2) and water.	co(2)	105-110	carbonic anhydrase 4	Oryctolagus cuniculus	0-26
11254287-1	2000	Macroscopic measurements show that Pb(II) uptake on iron-(hydr)oxides can be altered significantly by dissolved carbonate (enhanced up to 18% at pH 5 and decreased above pH approximately 6.5 in analyses at 1 atm CO(2)).	co(2)	212-217	submaxillary gland androgen regulated protein 3B	Homo sapiens	35-41
10838120-12	2000	In contrast, HAL produced a fivefold increase in serum PRL in animals where blood was collected under CO(2) anesthesia at euthanization.	co(2)	102-107	prolactin	Rattus norvegicus	55-58
10838120-13	2000	Hence, collection of blood from animals under CO(2) anesthesia at euthanization is an acceptable approach for detection of compounds that increase PRL.	co(2)	46-51	prolactin	Rattus norvegicus	147-150
10699966-3	2000	Exposures of the oocytes to CO(2) for 4-6 min produced reversible and concentration-dependent inhibitions of Kir1.1 and Kir2.3 currents, but had no effect on Kir2.1 and Kir6.1 currents.	co(2)	28-33	potassium inwardly rectifying channel subfamily J member 1 S homeolog	Xenopus laevis	109-115
10699966-3	2000	Exposures of the oocytes to CO(2) for 4-6 min produced reversible and concentration-dependent inhibitions of Kir1.1 and Kir2.3 currents, but had no effect on Kir2.1 and Kir6.1 currents.	co(2)	28-33	potassium inwardly rectifying channel subfamily J member 4 S homeolog	Xenopus laevis	120-126
10746996-2	2000	Exposure to ET-1 (10 nmol/L) raised pH(i) by 0.13+/-0.03 U (P<0.05) in papillary muscles superfused with nominally HCO(3)(-)-free solution, whereas no significant change was detected under CO(2)/HCO(3)(-)-buffered medium.	co(2)	192-197	endothelin 1	Homo sapiens	12-16
10746996-3	2000	However, if ET-1 was applied to muscles pretreated with the anion exchanger inhibitor 4-acetamido-4"-isothiocyanato-stilbene-2, 2"-disulfonic acid, pH(i) increased by 0.09+/-0.02 U (P<0.05) in the presence of CO(2)/HCO(3)(-) buffer.	co(2)	212-217	endothelin 1	Homo sapiens	12-16
10681404-6	2000	In mice pre-injected with gluthatione S-transferase-receptor-associated protein to block LRP binding, there was a marked inhibition of the appearance of (13)CO(2) in the expired breath of homozygous LDLr-deficient mice, supporting the role of LRP in vivo.	co(2)	157-162	low density lipoprotein receptor-related protein 1	Mus musculus	89-92
10681404-6	2000	In mice pre-injected with gluthatione S-transferase-receptor-associated protein to block LRP binding, there was a marked inhibition of the appearance of (13)CO(2) in the expired breath of homozygous LDLr-deficient mice, supporting the role of LRP in vivo.	co(2)	157-162	low density lipoprotein receptor	Mus musculus	199-203
10664617-1	2000	Phosphoenolpyruvate carboxylase catalyses the primary assimilation of CO(2) in Crassulacean acid metabolism plants.	co(2)	70-75	phosphoenolpyruvate carboxykinase 1	Homo sapiens	0-31
10918305-4	2000	Here, a new model is proposed in which glutamate uptake via the excitatory amino acid transporter (EAAT) is functionally coupled to other glial transporters, in particular the sodium-bicarbonate cotransporter (NBC) and the monocarboxylate transporter (MCT), as well as other glial functions, such as calcium signalling, a high potassium conductance and CO(2) consumption.	co(2)	353-358	solute carrier family 16 member 1	Homo sapiens	223-250
10748321-7	2000	SEF specific to painful stimulation is also recorded following painful stimulation by CO(2) laser beam.	co(2)	86-91	interleukin 17 receptor D	Homo sapiens	0-3
10869726-5	2000	The P2 purinoceptor antagonists, suramin and PPADS blunt the respiratory responses to changes in arterial CO(2) levels when micro-injected into the VLM.	co(2)	106-111	pyrimidinergic receptor P2Y6	Homo sapiens	4-19
10869726-7	2000	As the effects of agonist activation of P2X(2) purinoceptors expressed in HEK293 cells and Xenopus oocytes are potentiated by lowering pH, these data imply that the central respiratory response to CO(2) depends in part on the pH sensitivity of purinoreceptors located on inspiratory neurones.	co(2)	197-202	purinergic receptor P2X 2	Homo sapiens	40-46
10748119-5	2000	SIN-1 (150 micrometer)-mediated oxidation of NADH (200 micrometer) was half-maximally inhibited by low ascorbate concentrations (61-75 micrometer), both in the absence and presence of CO(2).	co(2)	184-189	MAPK associated protein 1	Homo sapiens	0-5
10820142-10	2000	[(14)C]CO(2) gas was decreased by the addition of iodoacetic acid, DL-fluorocitric acid, or gamma-butyrobetaine to this system, and subsequent thin-layer chromatography analyses of perfusates revealed that MET-88 was first converted to 3-hydroxypropionic acid by gamma-butyrobetaine hydroxylase and then was biosynthesized to glucose and metabolized to CO(2) gas via the glycolytic pathway and tricarboxylic acid cycle.	co(2)	7-12	gamma-butyrobetaine hydroxylase 1	Rattus norvegicus	263-294
10806233-6	2000	Therefore, the high levels of PEPC protein in the cytosol of C(4) mesophyll cells might be an adaptation for sustaining the steady-state rate of flux through the photosynthetic CO(2) assimilation pathway despite the limitations imposed by the PEPC kinetic properties and the conditions of its environment.	co(2)	177-182	MLO-like protein 4	Zea mays	30-34
10749735-3	2000	Changes in pH(i) were induced by local external application of NH(4)Cl, CO(2), or sodium propionate.	co(2)	72-77	glucose-6-phosphate isomerase	Homo sapiens	11-13
10649979-6	2000	(+)-1-N-[2,5-(S, R)-Dimethyl-4-N-(4-cyanobenzoyl)piperazine]-(R)-3,3, 3-trifluoro-2-hydroxy-2-methylpropanamide (14e) inhibits PDHK in the primary enzymatic assay with an IC(50) of 16 +/- 2 nM, enhances the oxidation of [(14)C]lactate into (14)CO(2) in human fibroblasts with an EC(50) of 57 +/- 13 nM, diminishes lactate significantly 2.5 h post-oral-dose at doses as low as 1 micromol/kg, and increases the ex vivo activity of PDH in muscle, liver, and fat tissues in normal Sprague-Dawley rats.	co(2)	244-249	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	127-130
10813890-3	2000	However, the radical generation efficiencies of 1 varied only slightly, from 53 (R = Me) to 63% (R = Bu(t)()), supporting a mechanism involving concerted two-bond scission within the solvent cage to generate the tert-butyl radical, CO(2), and an alkoxyl radical.	co(2)	232-237	telomerase reverse transcriptase	Homo sapiens	212-216
10631272-7	2000	A double mutant, deficient in both the high-affinity nitrate transporter genes and NR, excreted nitrite at high CO(2) only when nitrate was present at mM concentrations.	co(2)	112-117	uncharacterized protein	Chlamydomonas reinhardtii	83-85
10642388-14	2000	The results demonstrate that 1) periodic breathing provides a mechanism for acute hypercapnia in OSA, 2) acute hypercapnia during periodic breathing may occur without a decrease in average minute ventilation, supporting the presence of temporal V/Q mismatch, as predicted from our model, and 3) compensation for CO(2) accumulation during apnea/hypopnea may be limited by the duration of the interevent interval.	co(2)	312-317	AT-rich interaction domain 1B	Homo sapiens	97-103
16228420-0	2000	A mathematical model of C(4) photosynthesis: The mechanism of concentrating CO(2) in NADP-malic enzyme type species.	co(2)	76-81	complement C4A (Rodgers blood group)	Homo sapiens	24-28
10634913-4	2000	Attenuation of ClpP did not affect growth rates under normal conditions but restricted the ability of the cells to adapt to elevated CO(2) levels.	co(2)	133-138	ATP-dependent Clp protease proteolytic subunit	Chlamydomonas reinhardtii	15-19
10531501-1	1999	Phosphoenolpyruvate carboxylase is a key enzyme in the fixation of atmospheric CO(2) in C(4) and crassulacean acid metabolism (CAM) plants.	co(2)	79-84	MLO-like protein 4	Zea mays	0-31
10556122-5	1999	Mean (+/- SD) twitch Pdi (TwPdi) fell significantly (p < 0.01) at 20 min after the control and hypercapnic MVV; (30.4 [7.8] to 27.0 [8.1] cm H(2)O control and 30.3 [4.1] to 27.3 [5.0] cm H(2)O CO(2)) and remained significantly (p < 0.01) below baseline.	co(2)	196-201	peptidyl arginine deiminase 1	Homo sapiens	21-24
10541953-0	1999	Growth hormone treatment increases CO(2) response, ventilation and central inspiratory drive in children with Prader-Willi syndrome.	co(2)	35-40	growth hormone 1	Homo sapiens	0-14
10594120-0	1999	CO(2)-responsive transcriptional regulation of CAH1 encoding carbonic anhydrase is mediated by enhancer and silencer regions in Chlamydomonas reinhardtii.	co(2)	0-5	uncharacterized protein	Chlamydomonas reinhardtii	47-51
10594120-0	1999	CO(2)-responsive transcriptional regulation of CAH1 encoding carbonic anhydrase is mediated by enhancer and silencer regions in Chlamydomonas reinhardtii.	co(2)	0-5	uncharacterized protein	Chlamydomonas reinhardtii	61-79
10594120-1	1999	Chlamydomonas reinhardtii adapts to the stress of CO(2)-limiting conditions through the induction of a set of genes including CAH1, which encodes a periplasmic carbonic anhydrase.	co(2)	50-55	uncharacterized protein	Chlamydomonas reinhardtii	126-130
10594120-1	1999	Chlamydomonas reinhardtii adapts to the stress of CO(2)-limiting conditions through the induction of a set of genes including CAH1, which encodes a periplasmic carbonic anhydrase.	co(2)	50-55	uncharacterized protein	Chlamydomonas reinhardtii	160-178
10594120-2	1999	CAH1 is up-regulated under low-CO(2) conditions (air containing 0.04% [v/v] CO(2)) in the presence of light, whereas it is down-regulated under high-CO(2) conditions (5% [v/v] CO(2)) or in the dark.	co(2)	31-36	uncharacterized protein	Chlamydomonas reinhardtii	0-4
10594120-2	1999	CAH1 is up-regulated under low-CO(2) conditions (air containing 0.04% [v/v] CO(2)) in the presence of light, whereas it is down-regulated under high-CO(2) conditions (5% [v/v] CO(2)) or in the dark.	co(2)	76-81	uncharacterized protein	Chlamydomonas reinhardtii	0-4
10594120-2	1999	CAH1 is up-regulated under low-CO(2) conditions (air containing 0.04% [v/v] CO(2)) in the presence of light, whereas it is down-regulated under high-CO(2) conditions (5% [v/v] CO(2)) or in the dark.	co(2)	76-81	uncharacterized protein	Chlamydomonas reinhardtii	0-4
10594120-2	1999	CAH1 is up-regulated under low-CO(2) conditions (air containing 0.04% [v/v] CO(2)) in the presence of light, whereas it is down-regulated under high-CO(2) conditions (5% [v/v] CO(2)) or in the dark.	co(2)	76-81	uncharacterized protein	Chlamydomonas reinhardtii	0-4
10541953-3	1999	During GH treatment, resting ventilation increased by 26%, P(0.1) by 72% and the response to CO(2) by 65% (P < 0.002, <0.04 and <0.02, respectively).	co(2)	93-98	growth hormone 1	Homo sapiens	7-9
10529183-3	1999	The efficiency of either Zn-Cam or Co-Cam for CO(2) hydration (k(cat)/K(m)) was severalfold greater than HCO(3-) dehydration at physiological pH values, a result consistent with the proposed physiological function for Cam during growth on acetate.	co(2)	46-51	calmodulin 3	Homo sapiens	28-31
10529183-3	1999	The efficiency of either Zn-Cam or Co-Cam for CO(2) hydration (k(cat)/K(m)) was severalfold greater than HCO(3-) dehydration at physiological pH values, a result consistent with the proposed physiological function for Cam during growth on acetate.	co(2)	46-51	calmodulin 3	Homo sapiens	38-41
10529183-3	1999	The efficiency of either Zn-Cam or Co-Cam for CO(2) hydration (k(cat)/K(m)) was severalfold greater than HCO(3-) dehydration at physiological pH values, a result consistent with the proposed physiological function for Cam during growth on acetate.	co(2)	46-51	calmodulin 3	Homo sapiens	38-41
10529183-4	1999	For both Zn- and Co-Cam, the steady-state parameter k(cat) for CO(2) hydration was pH-dependent with a pK(a) of 6.5-6.8, whereas k(cat)/K(m) was dependent on two ionizations with pK(a) values of 6.7-6.9 and 8.2-8.4.	co(2)	63-68	calmodulin 3	Homo sapiens	20-23
19003130-6	1999	Furthermore, we found that hIL-6 production level of I13 was slightly improved by raising the CO(2) concentration from 5 to 8% possibly because of the enhanced growth rate.	co(2)	94-99	interleukin 6	Homo sapiens	27-32
10516283-7	1999	CO(2) stimulated NBC activity normally in beta-galactosidase-expressing and untransfected control cells.	co(2)	0-5	galactosidase beta 1	Homo sapiens	42-60
10516283-9	1999	CO(2) stimulation increased both total SFK activity and specific tyrosine phosphorylation of Src.	co(2)	0-5	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	39-42
10516283-9	1999	CO(2) stimulation increased both total SFK activity and specific tyrosine phosphorylation of Src.	co(2)	0-5	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	93-96
10516283-10	1999	The specific MEK1/2 inhibitor PD-98059 completely inhibited the CO(2) stimulation of NBC activity as well as the accompanying phosphorylation and activation of ERK1/2.	co(2)	64-69	mitogen-activated protein kinase kinase 1	Homo sapiens	13-19
10516283-11	1999	Our data suggest the involvement of both SFKs, probably Src, and the "classic" MAPK pathway in mediating CO(2)-stimulated NBC activity in renal epithelial cells.	co(2)	105-110	mitogen-activated protein kinase 3	Homo sapiens	79-83
10493928-1	1999	Oxalate oxidase (EC 1.2.3.4) catalyses the conversion of oxalate and dioxygen into CO(2) and H(2)O(2).	co(2)	83-88	LOC548260	Hordeum vulgare	0-15
10516186-12	1999	The specific reasons why the pial arteriolar CO(2) reactivity gains a K(+)-channel and epoxygenase dependence only under conditions of nNOS inhibition and cGMP restoration remain to be identified.	co(2)	45-50	nitric oxide synthase 1	Rattus norvegicus	135-139
10484576-12	1999	The remaining E-I Alk CO(2) stores averaged 61 and 68% for 60 and 80% LAT WRs, respectively.	co(2)	22-27	ALK receptor tyrosine kinase	Homo sapiens	18-21
10484576-12	1999	The remaining E-I Alk CO(2) stores averaged 61 and 68% for 60 and 80% LAT WRs, respectively.	co(2)	22-27	linker for activation of T cells	Homo sapiens	70-73
10484576-13	1999	The kinetics of O(2) uptake correlated with the time course of the increase in CO(2) stores; the size of the O(2) deficit correlated with the size of the E-I Alk component of the CO(2) stores.	co(2)	179-184	ALK receptor tyrosine kinase	Homo sapiens	158-161
19003130-9	1999	However when cultured in 8% CO(2) condition, not only cell number, but also productivity increased significantly, resulted in great augmentation of hIL-6 production, maximum production being 88.6 mug/ml/3 days.	co(2)	28-33	interleukin 6	Homo sapiens	148-153
10415095-1	1999	A radiochemical assay was developed to measure the activity of beta-ureidopropionase in human liver homogenates which is based on the detection of the reaction product (14)CO(2) by liquid scintillation counting.	co(2)	172-177	beta-ureidopropionase 1	Homo sapiens	63-84
10455107-1	1999	Malonyl-CoA decarboxylase (MCD) catalyzes the proton-consuming conversion of malonyl-CoA to acetyl-CoA and CO(2).	co(2)	107-112	malonyl-CoA decarboxylase	Homo sapiens	0-25
10455107-1	1999	Malonyl-CoA decarboxylase (MCD) catalyzes the proton-consuming conversion of malonyl-CoA to acetyl-CoA and CO(2).	co(2)	107-112	malonyl-CoA decarboxylase	Homo sapiens	27-30
10433993-0	1999	CO(2)-induced expression of c-fos in the nucleus of the solitary tract and the area postrema of developing swine.	co(2)	0-5	protein c-Fos	Sus scrofa	28-33
22060575-8	1996	Drip loss from loin sections was highest for those in 100 % CO(2) (4.2 %) and lowest for those in vacuum (3.2 %).	co(2)	60-65	DRIPL	Sus scrofa	0-4
15539316-6	1999	ODC activity was measured by the release of (14)CO(2) from (14)C-L-ornithine.	co(2)	48-53	ornithine decarboxylase 1	Rattus norvegicus	0-3
10467036-2	1999	Desiree) plants expressing an antisense construct against chloroplastic fructose-1,6-bisphosphatase (FBPase, EC 3.1.3.11) in response to increasing photon flux densities, different relative air humidities and elevated CO(2) concentrations.	co(2)	218-223	fructose-1,6-bisphosphatase, cytosolic	Solanum tuberosum	72-99
10467036-2	1999	Desiree) plants expressing an antisense construct against chloroplastic fructose-1,6-bisphosphatase (FBPase, EC 3.1.3.11) in response to increasing photon flux densities, different relative air humidities and elevated CO(2) concentrations.	co(2)	218-223	fructose-1,6-bisphosphatase, cytosolic	Solanum tuberosum	101-107
10467036-10	1999	At 70-80% relative humidity and atmospheric CO(2) concentration the FBPase antisense plants had significantly higher leaf conductances than wild-type plants while no difference emerged at 60-70%.	co(2)	44-49	fructose-1,6-bisphosphatase, cytosolic	Solanum tuberosum	68-74
21644648-6	1998	The solubility of a uranium complex, UO(2)(tta)(2) TBP, in supercritical CO(2) at 40  C and over the pressure range 100-325 atm was determined, and it was found to be possible to attain solubilities in excess of 10(-)(2) M for metal species in unmodified supercritical CO(2).	co(2)	73-78	TATA-box binding protein	Homo sapiens	51-54
18966629-1	1996	Considerable disparity exists in the published thermodynamic data for selected species in the Ca(2+) /CO(2)/H(2)O system near 25 degrees C and 1 atm pressure.	co(2)	102-107	cullin associated and neddylation dissociated 1	Homo sapiens	137-144
21102912-1	1996	Measurements of pure CO(2) absorption in the 2.3-mum region are presented.	co(2)	21-26	latexin	Homo sapiens	49-52
10749997-4	1999	Natriuretic peptides (ANP, BNP, CNP, urodilatin) completely inhibited pH(i) recovery in the absence of and by approximately 40% in the presence of HCO(3)(-)/CO(2).	co(2)	157-162	2',3'-cyclic nucleotide 3' phosphodiesterase	Rattus norvegicus	32-35
18475791-3	1997	All of such activators are of the non-competitive type towards CO(2) hydration and 4-nitrophenylacetate hydrolysis for both human isozymes (HCA I and HCA II).	co(2)	63-68	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	140-156
15091749-8	1994	The authors suggest that the low atmospheric CO(2) concentration may have favoured the C-4 plants in ice age vegetation types.	co(2)	45-50	complement C4A (Rodgers blood group)	Homo sapiens	87-90
15299369-8	1994	It is proposed that the presence of the inhibitor Au(CN)(2)(-) results in a conformational reorientation of the activity-linked group, due to hydrogen-bond formation with the inhibitor, which in turn sterically hinders the binding of the substrate CO(2) molecule in the active site, leading to the inhibition of HCAI enzyme.	co(2)	248-253	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	312-316
20577355-2	1990	Using the theory developed in Part 1, the receiving efficiency as a function of range, eta(z), is calculated under different conditions for the NOAA/ERL/Wave Propagation Laboratory CO(2) Doppler lidar.	co(2)	181-186	endothelin receptor type A	Homo sapiens	87-90
16668796-8	1992	The role of enhanced catalase activity in reducing photorespiratory CO(2) is discussed.	co(2)	68-73	catalase isozyme 1	Nicotiana tabacum	21-29
16667803-2	1990	When photoautotrophically grown high-CO(2) cells were transferred to low-CO(2) conditions, they exhibited a significant accumulation of the 2.0-kilobase CA transcript after 1 hour with the maximum level reached after 2 hours.	co(2)	37-42	uncharacterized protein	Chlamydomonas reinhardtii	153-155
16667803-2	1990	When photoautotrophically grown high-CO(2) cells were transferred to low-CO(2) conditions, they exhibited a significant accumulation of the 2.0-kilobase CA transcript after 1 hour with the maximum level reached after 2 hours.	co(2)	73-78	uncharacterized protein	Chlamydomonas reinhardtii	153-155
16667650-5	1990	The results are consistent with a lowered release of photorespiratory CO(2) by the mutant because greater catalase activity inhibits the chemical decarboxylation of alpha-keto acids by peroxisomal H(2)O(2).	co(2)	70-75	catalase isozyme 1	Nicotiana tabacum	106-114
16666296-8	1988	An analysis of the curves relating the rate of accumulation of C(i) to the concentration of CO(2) or HCO(3) (-) supplied, in the presence or absence of carbonic anhydrase, indicated that under the experimental conditions used here, CO(2) was the preferred C(i) species taken up by Synechococcus.	co(2)	232-237	cd03379	Synechococcus elongatus PCC 7942	152-170
16667421-0	1990	A 36 Kilodalton Limiting-CO(2) Induced Polypeptide of Chlamydomonas Is Distinct from the 37 Kilodalton Periplasmic Carbonic Anhydrase.	co(2)	25-30	uncharacterized protein	Chlamydomonas reinhardtii	115-133
16667421-9	1990	The antibodies were also used to demonstrate the distinction between the limiting-CO(2) induced 36 kilodalton polypeptide and the similarly sized, limiting-CO(2) induced periplasmic carbonic anhydrase.	co(2)	156-161	uncharacterized protein	Chlamydomonas reinhardtii	182-200
20556155-7	1990	Using the curve-of growth method, the band intensities of the 5.2-,9.4-, and 10.4-microm CO(2) bands were estimated to be 0.0199 cm(-2) atm(-1) STP, 0.0340 cm(-2) atm(-1) STP and 0.0208 cm(-2) atm(-1) STP, respectively.	co(2)	89-94	sulfotransferase family 1A member 1	Homo sapiens	144-147
20556155-7	1990	Using the curve-of growth method, the band intensities of the 5.2-,9.4-, and 10.4-microm CO(2) bands were estimated to be 0.0199 cm(-2) atm(-1) STP, 0.0340 cm(-2) atm(-1) STP and 0.0208 cm(-2) atm(-1) STP, respectively.	co(2)	89-94	sulfotransferase family 1A member 1	Homo sapiens	171-174
20556155-7	1990	Using the curve-of growth method, the band intensities of the 5.2-,9.4-, and 10.4-microm CO(2) bands were estimated to be 0.0199 cm(-2) atm(-1) STP, 0.0340 cm(-2) atm(-1) STP and 0.0208 cm(-2) atm(-1) STP, respectively.	co(2)	89-94	sulfotransferase family 1A member 1	Homo sapiens	171-174
16667188-4	1989	Under these circumstances the flux of carbon through the C(4) acid cycle would have to exceed the net rate of CO(2) assimilation by 15.5%.	co(2)	110-115	complement C4A (Rodgers blood group)	Homo sapiens	57-61
16666647-0	1989	Regulation of Catalase Activity in Leaves of Nicotiana sylvestris by High CO(2).	co(2)	74-79	catalase isozyme 1	Nicotiana sylvestris	14-22
16666647-1	1989	The effect of high CO(2) (1% CO(2)/21% O(2)) on the activity of specific forms of catalase (CAT-1, -2, and -3) (EA Havir, NA McHale [1987] Plant Physiol 84: 450-455) in seedling leaves of tobacco (Nicotiana sylvestris, Nicotlana tabacum) was examined.	co(2)	19-24	catalase isozyme 1	Nicotiana tabacum	92-109
16666647-1	1989	The effect of high CO(2) (1% CO(2)/21% O(2)) on the activity of specific forms of catalase (CAT-1, -2, and -3) (EA Havir, NA McHale [1987] Plant Physiol 84: 450-455) in seedling leaves of tobacco (Nicotiana sylvestris, Nicotlana tabacum) was examined.	co(2)	29-34	catalase isozyme 1	Nicotiana tabacum	92-109
16666647-2	1989	In high CO(2), total catalase activity decreased by 50% in the first 2 days, followed by a more gradual decline in the next 4 days.	co(2)	8-13	catalase isozyme 1	Nicotiana sylvestris	21-29
16666647-4	1989	In contrast, the activity of CAT-3 catalase, a form with enhanced peroxidatic activity, increased 3-fold in high CO(2) relative to air controls after 4 days.	co(2)	113-118	catalase isozyme 1	Nicotiana sylvestris	35-43
16666647-7	1989	When seedlings were transferred to air after prolonged exposure to high CO(2) (13 days), the levels of CAT-1 catalase were partially restored while CAT-3 remained at its elevated level.	co(2)	72-77	catalase isozyme 1	Nicotiana sylvestris	103-108
16666647-7	1989	When seedlings were transferred to air after prolonged exposure to high CO(2) (13 days), the levels of CAT-1 catalase were partially restored while CAT-3 remained at its elevated level.	co(2)	72-77	catalase isozyme 1	Nicotiana sylvestris	109-117
16666686-4	1989	Addition of carbonic anhydrase to protoplasts after the period of rapid CO(2) uptake revealed that the removal of CO(2) from the medium in the light was due to selective and active CO(2) transport rather than uptake of total dissolved inorganic carbon.	co(2)	72-77	uncharacterized protein	Chlamydomonas reinhardtii	12-30
16666686-4	1989	Addition of carbonic anhydrase to protoplasts after the period of rapid CO(2) uptake revealed that the removal of CO(2) from the medium in the light was due to selective and active CO(2) transport rather than uptake of total dissolved inorganic carbon.	co(2)	114-119	uncharacterized protein	Chlamydomonas reinhardtii	12-30
16666686-4	1989	Addition of carbonic anhydrase to protoplasts after the period of rapid CO(2) uptake revealed that the removal of CO(2) from the medium in the light was due to selective and active CO(2) transport rather than uptake of total dissolved inorganic carbon.	co(2)	114-119	uncharacterized protein	Chlamydomonas reinhardtii	12-30
16666686-5	1989	In the light, low CO(2) cells and protoplasts incubated with carbonic anhydrase took up CO(2) at an apparently low rate which reflected the uptake of total dissolved inorganic carbon.	co(2)	18-23	uncharacterized protein	Chlamydomonas reinhardtii	61-79
16666686-5	1989	In the light, low CO(2) cells and protoplasts incubated with carbonic anhydrase took up CO(2) at an apparently low rate which reflected the uptake of total dissolved inorganic carbon.	co(2)	88-93	uncharacterized protein	Chlamydomonas reinhardtii	61-79
16666686-8	1989	During the linear uptake of CO(2), low CO(2) cells and protoplasts incubated with carbonic anhydrase showed similar rates of net O(2) evolution (102 and 108 micromoles per milligram of chlorophyll per hour, respectively).	co(2)	28-33	uncharacterized protein	Chlamydomonas reinhardtii	82-100
16666686-8	1989	During the linear uptake of CO(2), low CO(2) cells and protoplasts incubated with carbonic anhydrase showed similar rates of net O(2) evolution (102 and 108 micromoles per milligram of chlorophyll per hour, respectively).	co(2)	39-44	uncharacterized protein	Chlamydomonas reinhardtii	82-100
16666686-12	1989	The external carbonic anhydrase is important in the supply to the cells of free CO(2) from the dehydration of HCO(3) (-).	co(2)	80-85	uncharacterized protein	Chlamydomonas reinhardtii	13-31
16666121-8	1988	This suggests a stimulation of the release of C-1 as CO(2) at the level of the glucose 6-phosphate oxidation pathway, as expected if NADPH was the electron donor for ferricyanide reduction.	co(2)	53-58	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	46-49
16666234-7	1988	Transfer of air-grown cells to a high CO(2) environment resulted in the elimination of the CA transcript after 60 minutes of exposure.	co(2)	38-43	uncharacterized protein	Chlamydomonas reinhardtii	91-93
16347526-3	1988	During syntrophic methanogenesis, flocs were the primary site for formate production via ethanol-dependent CO(2) reduction, with a formate production rate and methanogenic turnover constant of 660 muM/h and 0.044/min, respectively.	co(2)	107-112	latexin	Homo sapiens	197-200
16347526-4	1988	Floc preparations accumulated fourfold-higher levels of formate (40 muM) than digestor contents, and the free flora was the primary site for formate cleavage to CO(2) and H(2) (90 muM formate per h).	co(2)	161-166	latexin	Homo sapiens	180-183
20501291-3	1988	The role of this glutamate receptor site was investigated by studying the effects of select glutamate receptor agonists and antagonists and of ?-aminobutyric acid on the basal- and on the norepinephrine-stimulated activity of arylalkylamine N-acetyltransferase in rat pineal glands that were incubated in Dulbecco"s Modified Eagle Medium at 37 degrees C for 20 min in an atmosphere of 5% CO(2)/95% O(2).	co(2)	388-393	aralkylamine N-acetyltransferase	Rattus norvegicus	226-260
16665405-0	1987	Anapleurotic CO(2) Fixation by Phosphoenolpyruvate Carboxylase in C(3) Plants.	co(2)	13-18	phosphoenolpyruvate carboxylase	Nicotiana tabacum	31-62
16665837-3	1987	The K(m)CO(2) was 1.1 millimolar for NADP malic enzyme and 2.5 millimolar for PEP carboxykinase.	co(2)	8-13	phosphoenolpyruvate carboxykinase 1	Homo sapiens	78-95
16665837-7	1987	For NADP malic enzyme CO(2) was shown to be the inhibitory species but PEP carboxykinase and NAD malic enzyme were apparently inhibited about equally by CO(2) and HCO(3) (-).	co(2)	153-158	phosphoenolpyruvate carboxykinase 1	Homo sapiens	71-88
16665461-12	1987	Short-term growth (5 days) of tobacco seedlings under atmospheric conditions suppressing photorespiration (1% CO(2)/21% O(2)) reduced total catalase activity and caused a decline in peak 1 catalase and a substantial increase in the activity of peaks 2 and 3 relative to air-grown seedlings at the same stage.	co(2)	110-115	catalase isozyme 1	Nicotiana tabacum	140-148
16665461-12	1987	Short-term growth (5 days) of tobacco seedlings under atmospheric conditions suppressing photorespiration (1% CO(2)/21% O(2)) reduced total catalase activity and caused a decline in peak 1 catalase and a substantial increase in the activity of peaks 2 and 3 relative to air-grown seedlings at the same stage.	co(2)	110-115	catalase isozyme 1	Nicotiana tabacum	189-197
16665195-2	1987	At pH = 5.5 and 20% O(2), cells grown in HCO(3) (-) medium (low CO(2), pH >/= 9.0) exhibited a higher affinity for external CO(2) (K((1/2))(CO(2)) = 40 +/- 6 micromolar) than the cells grown for at least 24 hours in high-CO(2) medium (pH = 6.5), (K((1/2))(CO(2)) = 94 +/- 16 micromolar).	co(2)	64-69	HCO3	Sus scrofa	41-47
16665291-4	1987	Both CO(2)-enrichment and drought stress reduced the total (HCO(3) (-)/Mg(2+)-activated) extractable ribulose-1,5-bisphosphate carboxylase (RuBPCase) activity, as expressed on a chlorophyll basis.	co(2)	5-10	ribulose bisphosphate carboxylase small subunit, chloroplastic 1	Glycine max	101-138
16665291-4	1987	Both CO(2)-enrichment and drought stress reduced the total (HCO(3) (-)/Mg(2+)-activated) extractable ribulose-1,5-bisphosphate carboxylase (RuBPCase) activity, as expressed on a chlorophyll basis.	co(2)	5-10	ribulose bisphosphate carboxylase small subunit, chloroplastic 1	Glycine max	140-148
16665291-8	1987	The K(m)(CO(2)) values of activated RuBPCase from stressed and unstressed plants were similar; 15.0 and 12.6 micromolar, respectively.	co(2)	9-14	ribulose bisphosphate carboxylase small subunit, chloroplastic 1	Glycine max	36-44
16665195-2	1987	At pH = 5.5 and 20% O(2), cells grown in HCO(3) (-) medium (low CO(2), pH >/= 9.0) exhibited a higher affinity for external CO(2) (K((1/2))(CO(2)) = 40 +/- 6 micromolar) than the cells grown for at least 24 hours in high-CO(2) medium (pH = 6.5), (K((1/2))(CO(2)) = 94 +/- 16 micromolar).	co(2)	127-132	HCO3	Sus scrofa	41-47
16665195-2	1987	At pH = 5.5 and 20% O(2), cells grown in HCO(3) (-) medium (low CO(2), pH >/= 9.0) exhibited a higher affinity for external CO(2) (K((1/2))(CO(2)) = 40 +/- 6 micromolar) than the cells grown for at least 24 hours in high-CO(2) medium (pH = 6.5), (K((1/2))(CO(2)) = 94 +/- 16 micromolar).	co(2)	127-132	HCO3	Sus scrofa	41-47
16665195-5	1987	The high-pH, HCO(3) (-)-grown cells, when exposed to low pH (5.5) conditions, exhibited a response indicating an ability to fix CO(2) which exceeded the CO(2) externally supplied, and the reverse situation has been observed in high-CO(2)-grown cells.	co(2)	128-133	HCO3	Sus scrofa	13-19
16665195-5	1987	The high-pH, HCO(3) (-)-grown cells, when exposed to low pH (5.5) conditions, exhibited a response indicating an ability to fix CO(2) which exceeded the CO(2) externally supplied, and the reverse situation has been observed in high-CO(2)-grown cells.	co(2)	153-158	HCO3	Sus scrofa	13-19
16665195-5	1987	The high-pH, HCO(3) (-)-grown cells, when exposed to low pH (5.5) conditions, exhibited a response indicating an ability to fix CO(2) which exceeded the CO(2) externally supplied, and the reverse situation has been observed in high-CO(2)-grown cells.	co(2)	153-158	HCO3	Sus scrofa	13-19
16347020-5	1986	Experiments with [C]EDB showed that EDB was converted to approximately equal amounts of CO(2) and apparent cellular carbon; only small amounts of added C were not attributable to these products or unreacted EDB.	co(2)	88-93	vesicle associated membrane protein 8	Homo sapiens	36-39
16665146-1	1986	The biosynthesis of diamine oxidase (DAO; EC 1.4.3.6) in leaf blades of subterranean clover (Trifolium subterraneum L. cv Seaton Park) was followed by labeling whole plants with (14)CO(2).	co(2)	182-187	D-amino-acid oxidase	Oryctolagus cuniculus	20-35
16665079-1	1986	Some physiological characteristics of a mutant (E(1)) of Anacystis nidulans R(2), incapable of growing at air level of CO(2), are described.	co(2)	119-124	small nucleolar RNA, H/ACA box 73A	Homo sapiens	48-52
16664994-6	1986	There was a highly significant negative correlation (r = -0.90) between CO(2) compensation concentration and the logarithm of phosphoenolpyruvate carboxylase activity in the parents and hybrids, suggesting involvement of this enzyme in controlling the CO(2) compensation concentration.	co(2)	72-77	phosphoenolpyruvate carboxykinase 1	Homo sapiens	126-157
16664994-6	1986	There was a highly significant negative correlation (r = -0.90) between CO(2) compensation concentration and the logarithm of phosphoenolpyruvate carboxylase activity in the parents and hybrids, suggesting involvement of this enzyme in controlling the CO(2) compensation concentration.	co(2)	252-257	phosphoenolpyruvate carboxykinase 1	Homo sapiens	126-157
16347020-5	1986	Experiments with [C]EDB showed that EDB was converted to approximately equal amounts of CO(2) and apparent cellular carbon; only small amounts of added C were not attributable to these products or unreacted EDB.	co(2)	88-93	vesicle associated membrane protein 8	Homo sapiens	36-39
19730506-1	1985	Infrared supercontinua spanning the range 3-14 microm were observed when an intense pulse generated from a CO(2) laser was passed into GaAs, AgBr, ZnSe, and CdS crystals.	co(2)	107-112	CDP-diacylglycerol synthase 1	Homo sapiens	157-160
16664621-6	1986	Therefore, the chloroplast tye of PPDK mRNA is present prior to the appearance of leaf morphology.Analysis of the labeled products of (14)CO(2) fixation by nonchlorophyllous calli indicated beta-carboxylation to give acids of the tricarboxylic acid cycle, but no incorporation into phosphoglycerate.	co(2)	138-143	pyruvate, phosphate dikinase 1, chloroplastic	Zea mays	34-38
16664107-0	1985	Relationships between CO(2) Exchange Rates and Activities of Pyruvate,Pi Dikinase and Ribulose Bisphosphate Carboxylase, Chlorophyll Concentration, and Cell Volume in Maize Leaves.	co(2)	22-27	pyruvate, phosphate dikinase 1, chloroplastic	Zea mays	61-81
16664257-5	1985	Activities of ribulose bisphosphate carboxylase and phosphoenolpyruvate carboxylase (expressed in micromoles CO(2) per milligram protein per hour) averaged 1.95 and 8.87 for the flower buds, and 28.5 and 3.6 for the leaves, respectively.	co(2)	109-114	phosphoenolpyruvate carboxylase	Citrus sinensis	52-83
16663207-2	1983	This mutant strain, designated pmp-1-16-5K (gene locus pmp-1), was selected on the basis of a requirement of elevated CO(2) concentration for photoautrophic growth.	co(2)	118-123	peroxisomal biogenesis factor 19	Homo sapiens	31-36
16663633-7	1984	The tissue location and developmental profile of seed PPDK are consistent with a metabolic role of providing phosphoenolpyruvate as a substrate for recapturing respiratory CO(2) in the seed, and possibly for amino acid interconversions during development.	co(2)	172-177	pyruvate, phosphate dikinase 1, chloroplastic	Triticum aestivum	54-58
16593518-0	1984	Biosynthesis of carbonic anhydrase in Chlamydomonas reinhardtii during adaptation to low CO(2).	co(2)	89-94	uncharacterized protein	Chlamydomonas reinhardtii	16-34
16593518-1	1984	The unicellular green alga Chlamydomonas reinhardtii synthesizes carbonic anhydrase in response to low levels of CO(2) (i.e., air levels of CO(2)).	co(2)	113-118	uncharacterized protein	Chlamydomonas reinhardtii	65-83
16593518-7	1984	Since translatable RNA for the polypeptide responsible for carbonic anhydrase activity was only present in cells that experienced low levels of CO(2), the adaptation process either involves the regulation of transcription of the carbonic anhydrase gene (and perhaps other genes involved in adaptation) or the post-transcriptional processing of the messenger RNA.	co(2)	144-149	uncharacterized protein	Chlamydomonas reinhardtii	59-77
16663207-2	1983	This mutant strain, designated pmp-1-16-5K (gene locus pmp-1), was selected on the basis of a requirement of elevated CO(2) concentration for photoautrophic growth.	co(2)	118-123	peroxisomal biogenesis factor 19	Homo sapiens	55-60
20389992-3	1982	A quarterwavelength optical thickness layer of BaF(2) is shown experimentally to be an effective single-layer antireflection coating for NaCl and KCl surfaces at 10.6-microm wavelength and to have a high damage threshold for high-power cw CO(2) laser radiation.	co(2)	239-244	BANF family member 2	Homo sapiens	47-52
20396238-1	1982	Results of extinction measurements of CO(2) laser radiation by fog and rain are discussed.	co(2)	38-43	zinc finger protein, FOG family member 1	Homo sapiens	63-66
16661765-5	1981	Incubation of excised PIIF-induced plants in CO(2)-free air doubled the rate of in vivo synthesis of Inhibitor I over that in normal air (Ryan CA 1977 Biochem Biophys Res Commun 77: 1004-1008) but did not affect the rate of in vivo Inhibitor II accumulation.	co(2)	45-50	wound-induced proteinase inhibitor 1	Solanum lycopersicum	22-26
20372473-0	1982	Fog dispersal by CO(2) laser pulses: an exact solution including prevaporization heating.	co(2)	17-22	zinc finger protein, FOG family member 1	Homo sapiens	0-3
7287622-1	1981	An anaerobic marine spirochete (strain MA-2) fermented glucose and formed ethanol, acetic acid, CO(2), and H(2) as end products.	co(2)	96-101	PNMA family member 2	Homo sapiens	39-43
16345825-7	1981	The respiratory index [CO(2)/(CO(2) + CH(4))] for [2-C]acetate catabolism, a measure of terminal carbon flow, was >/=0.96 for sediment with high sulfate, but in sediments with sulfate as little as 10 muM in the interstitial water, respiratory index values of </=0.22 were obtained.	co(2)	23-28	latexin	Homo sapiens	203-206
16661765-7	1981	Messenger RNA isolated from PIIF-induced plants incubated in the presence or absence of CO(2) was translated in vitro.	co(2)	88-93	wound-induced proteinase inhibitor 1	Solanum lycopersicum	28-32
16661586-1	1980	A survey of the K(m)(CO(2)) values of ribulose-1,5-bisphosphate carboxylase from 60 grass species shows that enzyme from C(3) grasses consistently exhibits lower K(m)(CO(2)) than does that from C(4) grasses.	co(2)	21-26	complement C3	Homo sapiens	121-125
20221126-2	1980	The CO(2) lidar was used to measure the ratio of transmission of the P(38) to the P(20) lines in the 10-microm band of CO(2).	co(2)	4-9	mitogen-activated protein kinase 14	Homo sapiens	69-74
20221126-2	1980	The CO(2) lidar was used to measure the ratio of transmission of the P(38) to the P(20) lines in the 10-microm band of CO(2).	co(2)	4-9	tubulin polymerization promoting protein family member 3	Homo sapiens	82-87
20221126-2	1980	The CO(2) lidar was used to measure the ratio of transmission of the P(38) to the P(20) lines in the 10-microm band of CO(2).	co(2)	119-124	mitogen-activated protein kinase 14	Homo sapiens	69-74
20221126-2	1980	The CO(2) lidar was used to measure the ratio of transmission of the P(38) to the P(20) lines in the 10-microm band of CO(2).	co(2)	119-124	tubulin polymerization promoting protein family member 3	Homo sapiens	82-87
16661004-3	1979	The maximum increase in PG activity occurred after C(2)H(2) and CO(2) production reached their peak.	co(2)	64-69	polygalacturonase	Solanum lycopersicum	24-26
16661356-4	1980	It was shown that the photoinhibition which follows exposure of intact leaflets of low light-grown bean plants to high light intensity in normal air is essentially similar to that which occurs when leaflets of plants grown in full sunlight are illuminated in the absence of CO(2) at low O(2) partial pressures.	co(2)	274-279	brain expressed associated with NEDD4 1	Homo sapiens	99-103
7396865-3	1980	During the early stage of ovarian development (9th day of incubation), the ornithine decarboxylase activity (in terms of pmol CO(2)/30min per mg of protein) was high (766); it decreased from the 10th to the 12th day (575-239), increased slightly from the 13th to the 15th day (306) and finally fell to a low value (192-20) from the 18th day of development to birth.	co(2)	126-131	ornithine decarboxylase	Gallus gallus	75-98
16661090-6	1979	Catalase inhibited this CO(2) release.	co(2)	24-29	catalase-3	Glycine max	0-8
20212653-1	1979	A new analysis is presented for the atmospheric transmission of the CO(2)(P-20) line, which includes pressure shift, bleaching, and tuning off-line center.	co(2)	68-73	tubulin polymerization promoting protein family member 3	Homo sapiens	74-78
16660753-4	1979	Catalase activity reached a maximum during the climacteric, simultaneously with increased ethylene and CO(2) formation.	co(2)	103-108	catalase isozyme 1	Solanum lycopersicum	0-8
20197926-1	1978	Freon-12 absorption coefficients for the P(22) through P(48) CO(2) waveguide laser transitions of the 00 degrees 1-(10 degrees 0, 02 degrees 0)(I) band are presented.	co(2)	61-66	calcineurin like EF-hand protein 1	Homo sapiens	41-46
19684679-0	1978	Heterogeneous condensation of BCl(3) in the presence of CO(2) laser irradiation.	co(2)	56-61	BCL3 transcription coactivator	Homo sapiens	30-36
20197926-1	1978	Freon-12 absorption coefficients for the P(22) through P(48) CO(2) waveguide laser transitions of the 00 degrees 1-(10 degrees 0, 02 degrees 0)(I) band are presented.	co(2)	61-66	interferon regulatory factor 9	Homo sapiens	55-60
16659894-2	1977	The rates of the enzyme reactions, using substrate amounts of HCO(3) (-), CO(2) or CO(2) plus carbonic anhydrase, show that HCO(3) (-) is the active species of "CO(2)" utilized by PEP carboxylase.	co(2)	74-79	phosphoenolpyruvate carboxylase 1	Zea mays	180-195
17248817-2	1978	ref(2)P is a gene for resistance to the hereditary, noncontagious Rhabdovirus sigma, responsible for CO(2) sensitivity in Drosophila melanogaster .	co(2)	101-106	refractory to sigma P	Drosophila melanogaster	0-7
23428-19	1977	Removal of external CO(2) or application of SITS (10(-4)M) caused some slowing of the rate of pH(i) recovery following acidification by removal of (NH(4))(2)SO(4).	co(2)	20-25	glucose-6-phosphate isomerase 1	Mus musculus	94-99
23429-4	1977	Reducing external Cl(-) did not inhibit pH(i) recovery, but reducing internal Cl(-), by exposing the cell to sulphate Ringer, inhibited pH(i) recovery from CO(2) application.4.	co(2)	156-161	glucose-6-phosphate isomerase	Homo sapiens	136-138
23429-5	1977	During pH(i) recovery from CO(2) application the internal Cl(-) concentration decreased.	co(2)	27-32	glucose-6-phosphate isomerase	Homo sapiens	7-9
23429-7	1977	Removal of external Na inhibited the pH(i) recovery from either CO(2) application or HCl injection.6.	co(2)	64-69	glucose-6-phosphate isomerase	Homo sapiens	37-39
16659894-2	1977	The rates of the enzyme reactions, using substrate amounts of HCO(3) (-), CO(2) or CO(2) plus carbonic anhydrase, show that HCO(3) (-) is the active species of "CO(2)" utilized by PEP carboxylase.	co(2)	83-88	phosphoenolpyruvate carboxylase 1	Zea mays	180-195
16659894-2	1977	The rates of the enzyme reactions, using substrate amounts of HCO(3) (-), CO(2) or CO(2) plus carbonic anhydrase, show that HCO(3) (-) is the active species of "CO(2)" utilized by PEP carboxylase.	co(2)	83-88	phosphoenolpyruvate carboxylase 1	Zea mays	180-195
16659894-3	1977	The K(m) values for CO(2) and HCO(3) (-) are 1.25 mm and 0.11 mm, respectively, which further suggest the preferential utilization of HCO(3) (-) by PEP carboxylase.	co(2)	20-25	phosphoenolpyruvate carboxylase 1	Zea mays	148-163
4812443-4	1974	Insulin further stimulates the conversion of glucose carbons into CO(2), but not into glyceride-glycerol.	co(2)	66-71	insulin	Homo sapiens	0-7
1220680-2	1975	Diamine oxidase inhibitors and carboxymethoxylamine (amino-oxyacetate) markedly inhibit the metabolism of [(14)C]putrescine to (14)CO(2), but affect different enzymes.	co(2)	131-136	amine oxidase copper containing 1	Homo sapiens	0-15
16659259-3	1975	The range in concentration of oxaloacetic acid needed for maximum phosphoenolpyruvate carboxykinase activity was 5 to 10 mm, and the Km for HCO(3) (-) in the exchange of (14)CO(2) into oxaloacetic acid was 26.8 mm.Changes in the activity of PEP carboxykinase and PEP carboxylase in berries were studied at weekly intervals throughout fruit development.	co(2)	174-179	phosphoenolpyruvate carboxykinase 1	Homo sapiens	241-258
20125978-3	1974	The possibility of chemical reactions induced by CO(2)-laser light is exemplified by the case of BCl(3) molecules.	co(2)	49-54	BCL3 transcription coactivator	Homo sapiens	97-103
4725035-2	1973	The fixation of CO(2) by pyruvate carboxylase in isolated rat brain mitochondria was investigated.	co(2)	16-21	pyruvate carboxylase	Rattus norvegicus	25-45
16658576-2	1973	Crassulacean acid metabolism plants apparently utilize both ribulose-1, 5-diphosphate carboxylase and phosphoenolpyruvate carboxylase to assimilate atmospheric CO(2) and, depending on environmental conditions, have (13)C/(12)C ratios indicative of either carboxylase or to any intermediate value.	co(2)	160-165	phosphoenolpyruvate carboxykinase 1	Homo sapiens	102-133
16592125-1	1973	Isolated mesophyll cells from leaves of plants that use the C(4) dicarboxylic acid pathway of CO(2) fixation have been used to demonstrate that oxaloacetic acid reduction to malic acid is coupled to the photochemical evolution of oxygen through the presumed production of NADPH.	co(2)	94-99	2,4-dienoyl-CoA reductase 1	Homo sapiens	272-277
4404506-8	1972	The CO(2) evolved by extracts was believed to derive from the carboxyl group on C-4 of the heterocyclic ring.	co(2)	4-9	complement C4A (Rodgers blood group)	Homo sapiens	80-83
20125223-1	1973	A pulsed CO(2) laser is used to irradiate single fog droplets.	co(2)	9-14	zinc finger protein, FOG family member 1	Homo sapiens	49-52
5056668-6	1972	This fraction is (Pa(CO2)/Pa(CO2))(2), where Pa(CO2) and Pa(CO2) are the mean partial pressures of expired alveolar and of arterial CO(2); in the other equation this fraction is [Pe(CO2)/Pa(CO2) (Vt - Vd(an) - Vd(m))](2) where Pe(CO2) is mixed expired Pco(2) and Vd(an) is anatomical dead space.	co(2)	132-137	complement C2	Homo sapiens	21-24
5056668-6	1972	This fraction is (Pa(CO2)/Pa(CO2))(2), where Pa(CO2) and Pa(CO2) are the mean partial pressures of expired alveolar and of arterial CO(2); in the other equation this fraction is [Pe(CO2)/Pa(CO2) (Vt - Vd(an) - Vd(m))](2) where Pe(CO2) is mixed expired Pco(2) and Vd(an) is anatomical dead space.	co(2)	132-137	complement C2	Homo sapiens	29-32
5056668-6	1972	This fraction is (Pa(CO2)/Pa(CO2))(2), where Pa(CO2) and Pa(CO2) are the mean partial pressures of expired alveolar and of arterial CO(2); in the other equation this fraction is [Pe(CO2)/Pa(CO2) (Vt - Vd(an) - Vd(m))](2) where Pe(CO2) is mixed expired Pco(2) and Vd(an) is anatomical dead space.	co(2)	132-137	complement C2	Homo sapiens	29-32
5049806-1	1972	DURING MYELOGRAPHY WE OBSERVED THE CONTRAST MATERIAL IN THE SPINAL SUBARACHNOID SPACE WHILE WE CHANGED: (1) the intracranial blood volume by CO(2) inhalation, hyperventilation, and jugular vein compression; (2) the intra-abdominal and intrathoracic pressure by forced expiration with glottis closed; and (3) the CSF volume by withdrawals and reinjections of fluid.	co(2)	141-146	colony stimulating factor 2	Homo sapiens	312-315
5101784-3	1971	Making certain stoichiometric assumptions about the oxidation of the C-1 and C-6 carbons of glucose to CO(2), the data are incorporated into a multicompartmental model describing the kinetics of plasma glucose, plasma bicarbonate, and the conversion of glucose to CO(2) by the hexose monophosphate pathway and all other series and parallel pathways which oxidize glucose carbon to CO(2) (EMP-TCA).	co(2)	264-269	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	69-80
4993858-7	1971	In seven of the normal dogs, administration of insulin and glucose increased removal of the infused ketones and increased the fraction of (14)C appearing in respiratory CO(2).	co(2)	169-174	insulin	Canis lupus familiaris	47-54
5101784-3	1971	Making certain stoichiometric assumptions about the oxidation of the C-1 and C-6 carbons of glucose to CO(2), the data are incorporated into a multicompartmental model describing the kinetics of plasma glucose, plasma bicarbonate, and the conversion of glucose to CO(2) by the hexose monophosphate pathway and all other series and parallel pathways which oxidize glucose carbon to CO(2) (EMP-TCA).	co(2)	264-269	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	69-80
16695927-5	1967	In four subjects, the effect of 6, 50, and 400 muU/ml of insulin was analyzed on conversion of glucose-1-carbon to CO(2), long chain fatty acids, and glycerides by adipose tissue segments only.	co(2)	115-120	insulin	Homo sapiens	57-64
20072385-4	1969	The optical properties of films of SiO, SiO(2), MgF(2), Al(2)MgO(4), and Te produced by the CO(2) laser evaporation technique are discussed.	co(2)	92-97	signal transducer and activator of transcription 5A	Homo sapiens	48-51
20076365-0	1970	The Temperature Dependence of the Self-Broadened Half-Width of the P-20 Line in the 001-100 Band of CO(2).	co(2)	100-105	tubulin polymerization promoting protein family member 3	Homo sapiens	67-71
20068838-0	1968	Atmospheric absorption at the line center of P(20) CO(2) laser radiation.	co(2)	51-56	tubulin polymerization promoting protein family member 3	Homo sapiens	45-50
20068838-1	1968	Atmospheric CO(2) absorption at the line center of P(20) CO(2) laser radiation has been calculated at different altitudes by using the relationship 1 - exp(-integral(l)(2)(l)(1) kdl).	co(2)	12-17	tubulin polymerization promoting protein family member 3	Homo sapiens	51-56
20068838-1	1968	Atmospheric CO(2) absorption at the line center of P(20) CO(2) laser radiation has been calculated at different altitudes by using the relationship 1 - exp(-integral(l)(2)(l)(1) kdl).	co(2)	57-62	tubulin polymerization promoting protein family member 3	Homo sapiens	51-56
13163358-7	1954	This suggests that the most sensitive site affected by disruption of the cells may be the steps involved in the regeneration of the "C-2 acceptor" for CO(2) fixation in photosynthesis.	co(2)	151-156	complement C2	Homo sapiens	133-136
20048825-3	1966	For example, a cell length of 1500 cm of CO(2) at 760-mm pressure, equivalent to the CO(2) content in 50,000 m of atmosphere at sea level, transmitted 20% of the energy in the band region from 4.0 micro to 5.5 micro.	co(2)	41-46	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	128-131
20048825-3	1966	For example, a cell length of 1500 cm of CO(2) at 760-mm pressure, equivalent to the CO(2) content in 50,000 m of atmosphere at sea level, transmitted 20% of the energy in the band region from 4.0 micro to 5.5 micro.	co(2)	85-90	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	128-131
16654455-2	1952	CO(2) Production by Bean Plants Treated with Labeled 2,4-Dichlorophenoxyacetic Acids.	co(2)	0-5	brain expressed associated with NEDD4 1	Homo sapiens	20-24
19873117-12	1939	The pH of sap has been determined by a new method which avoids the loss of gas (CO(2)), an important source of error.	co(2)	80-85	SH2 domain containing 1A	Homo sapiens	10-13
28835060-15	2017	P(c-et)CO(2)>20 mmHg before EGDT and >16.5 mmHg after EGDT both could predict the 28 d prognosis of patients with septic shock, and the effect of the former was equal to that of LAC, but the latter was better than LAC.	co(2)	7-12	lactase	Homo sapiens	184-187
19873204-3	1940	The data can be represented by the equation 2 CH(3)CHOHCH(3) + CO(2) --> 2 CH(3)COCH(3) + (CH(2)O) + H(2)O. Manometric experiments with suspensions of resting cells have fully corroborated the results obtained with growing cultures.	co(2)	63-68	cochlin	Homo sapiens	83-87
31340430-3	2019	Crystals harvested within 2-3 weeks proved to be the 1D-coordination polymer [Co(2)(NCS)2(MeOH)2]n and powder X-ray diffraction (PXRD) confirmed that the crystals selected for single-crystal X-ray diffraction were representative of the bulk samples.	co(2)	78-83	cytosolic thiouridylase subunit 2	Homo sapiens	84-89
19872836-3	1934	A stream of CO(2) is bubbled through the artificial sap to imitate its production by the living cell.	co(2)	12-17	SH2 domain containing 1A	Homo sapiens	52-55
19872836-4	1934	Potassium passes from the external solution through the non-aqueous layer into the artificial sap and there reacts with CO(2) to form KHCO(3): its rate of entrance depends on the supply of CO(2).	co(2)	189-194	SH2 domain containing 1A	Homo sapiens	94-97
19872836-6	1934	By regulating the supply of CO(2) and the osmotic pressure we are able to keep the volume and composition of the artificial sap approximately constant while maintaining a higher concentration of potassium than in the external solution.	co(2)	28-33	SH2 domain containing 1A	Homo sapiens	124-127
16994530-0	1934	The action of insulin on the r.q., oxygen utilization, CO(2) production and sugar utilization in the mammalian diabetic heart.	co(2)	55-60	insulin	Homo sapiens	14-21
19872792-2	1934	Some of the factors affecting penetration in living cells may be advantageously studied in models in which the organic salts KG and NaG diffuse from an aqueous solution A, through a non-aqueous layer B (representing the protoplasmic surface) into an aqueous solution C (representing the sap and hence called artificial sap) where they react with CO(2) to form KHCO(3) and NaHCO(3).	co(2)	346-351	NBAS subunit of NRZ tethering complex	Homo sapiens	132-135
19872792-21	1934	Since CO(2) and HCO(3) (-) diffuse into A and combine with KG and NaG the inward movement of potassium and sodium falls off in proportion as the concentration of KG and NaG is lessened.	co(2)	6-11	NBAS subunit of NRZ tethering complex	Homo sapiens	59-69
19872792-21	1934	Since CO(2) and HCO(3) (-) diffuse into A and combine with KG and NaG the inward movement of potassium and sodium falls off in proportion as the concentration of KG and NaG is lessened.	co(2)	6-11	NBAS subunit of NRZ tethering complex	Homo sapiens	66-69
28835060-15	2017	P(c-et)CO(2)>20 mmHg before EGDT and >16.5 mmHg after EGDT both could predict the 28 d prognosis of patients with septic shock, and the effect of the former was equal to that of LAC, but the latter was better than LAC.	co(2)	7-12	lactase	Homo sapiens	220-223
25038233-4	2014	This mechanism is fine-tuned via regulation of the nuclear NAB1 promoter, which is activated when linear photosynthetic electron flow is restricted by CO(2)-limitation in a photoheterotrophic context.	co(2)	151-156	uncharacterized protein	Chlamydomonas reinhardtii	59-63
30192485-11	2017	Thus the measurement data could be used as a new index of blood glucose level in human body, which showed the potential in clinical diagnosis of the ATR mid-infrared absorption spectrophotometry with external CO(2) laser source in noninvasive measurement of human blood glucose levels.	co(2)	209-214	ATR serine/threonine kinase	Homo sapiens	149-152
26265014-8	2015	The introduction of CdS can enhance CO(2) molecule adsorption, thereby accelerating photocatalytic CO(2) reduction to CH(4).	co(2)	36-41	CDP-diacylglycerol synthase 1	Homo sapiens	20-23
26307701-3	2015	Infrared multiphoton dissociation (IRMPD), using a CO(2) laser source at a wavelength of 10.6 mum, was applied to protonated vasopressin molecules.	co(2)	51-56	arginine vasopressin	Homo sapiens	125-136
23860249-7	2013	GDC activity is crucial for photorespiration; accordingly, morphological and physiological defects in er-ant1 plants were nearly completely abolished by application of high environmental CO(2) concentrations.	co(2)	187-192	aromatic and neutral transporter 1	Arabidopsis thaliana	105-109
24362561-8	2014	The appropriate concentrations of nitrogen, phosphorus in medium and CO(2) in aerated gas were determined as 8.8, 0.22 mmol L(-1) and 1 %, respectively.	co(2)	69-74	immunoglobulin kappa variable 1-16	Homo sapiens	124-135
24548973-1	2014	This study investigated the involvement of sensory nerves and, in particular, neuronal transient receptor potential vanilloid (TRPV) 1 channels, in the CO(2)-mediated regulation of cerebrovascular tone.	co(2)	152-157	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	87-134
24746043-0	2014	Cytoarchitecture and CO(2) sensitivity of Phox2b-positive Parafacial neurons in the newborn rat medulla.	co(2)	21-26	paired-like homeobox 2b	Rattus norvegicus	42-48
24746043-9	2014	In this chapter, we elaborate on the CO(2) sensitivity of Phox2b-positive/negative parafacial neurons and the cytoarchitecture in the newborn rat medulla, and discuss ionic mechanisms of CO(2) responsiveness.	co(2)	37-42	paired-like homeobox 2b	Rattus norvegicus	58-64
24103939-3	2013	The mean sizes of CO(2) clusters are estimated to be 0.28 +- 0.03 mum for CO(2)/H(2) and 0.26 +- 0.04 mum for CO(2)/He, respectively.	co(2)	18-23	complement C2	Homo sapiens	110-118
23292932-4	2013	The relationship between CO(2) and sea level we describe portrays the "likely" (68% probability) long-term sea-level response after Earth system adjustment over many centuries.	co(2)	25-30	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	107-110
23736345-4	2013	In this investigation, it is assumed that the energy delivered by the CO(2) laser is confined within a very thin surface layer of roughly 10 mum.	co(2)	70-75	latexin	Homo sapiens	141-144
23181524-7	2013	The knockout mutant bou-2 showed the hallmarks of a photorespiratory growth phenotype, an elevated CO(2)  compensation point, and excessive accumulation of glycine.	co(2)	99-104	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	20-23
23276202-7	2013	Also, the amount of managed oil sands CO(2) emissions, and therefore the CCS infrastructure, is very sensitive to the carbon price; significant capture and storage occurs only above 110$/tonne CO(2) in our simulations.	co(2)	38-43	copper chaperone for superoxide dismutase	Homo sapiens	73-76
23276202-7	2013	Also, the amount of managed oil sands CO(2) emissions, and therefore the CCS infrastructure, is very sensitive to the carbon price; significant capture and storage occurs only above 110$/tonne CO(2) in our simulations.	co(2)	193-198	copper chaperone for superoxide dismutase	Homo sapiens	73-76
23129207-7	2013	The observation that elevated CO(2) partly rescued the dfc phenotypes suggests that the alterations in N metabolism in dfc may be mainly due to a defect in photorespiration.	co(2)	30-35	DHFS-FPGS homolog C	Arabidopsis thaliana	55-58
23129207-7	2013	The observation that elevated CO(2) partly rescued the dfc phenotypes suggests that the alterations in N metabolism in dfc may be mainly due to a defect in photorespiration.	co(2)	30-35	DHFS-FPGS homolog C	Arabidopsis thaliana	119-122
23292932-2	2013	Here we use observations from five well-studied time slices covering the last 40 My to identify a well-defined and clearly sigmoidal relationship between atmospheric CO(2) and sea level on geological (near-equilibrium) timescales.	co(2)	166-171	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	176-179
23292932-4	2013	The relationship between CO(2) and sea level we describe portrays the "likely" (68% probability) long-term sea-level response after Earth system adjustment over many centuries.	co(2)	25-30	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	35-38
23485707-1	2013	Previous work showed that aquaporin 1 (AQP1), AQP4-M23, and AQP5 each has a characteristic CO(2)/NH(3) and CO(2)/H(2)O permeability ratio.	co(2)	91-96	aquaporin 1 (Colton blood group)	Homo sapiens	26-37
23485707-1	2013	Previous work showed that aquaporin 1 (AQP1), AQP4-M23, and AQP5 each has a characteristic CO(2)/NH(3) and CO(2)/H(2)O permeability ratio.	co(2)	91-96	aquaporin 1 (Colton blood group)	Homo sapiens	39-43
23485707-1	2013	Previous work showed that aquaporin 1 (AQP1), AQP4-M23, and AQP5 each has a characteristic CO(2)/NH(3) and CO(2)/H(2)O permeability ratio.	co(2)	91-96	aquaporin 4	Homo sapiens	46-50
23485707-1	2013	Previous work showed that aquaporin 1 (AQP1), AQP4-M23, and AQP5 each has a characteristic CO(2)/NH(3) and CO(2)/H(2)O permeability ratio.	co(2)	91-96	aquaporin 5	Homo sapiens	60-64
23485707-1	2013	Previous work showed that aquaporin 1 (AQP1), AQP4-M23, and AQP5 each has a characteristic CO(2)/NH(3) and CO(2)/H(2)O permeability ratio.	co(2)	107-112	aquaporin 1 (Colton blood group)	Homo sapiens	26-37
23485707-1	2013	Previous work showed that aquaporin 1 (AQP1), AQP4-M23, and AQP5 each has a characteristic CO(2)/NH(3) and CO(2)/H(2)O permeability ratio.	co(2)	107-112	aquaporin 1 (Colton blood group)	Homo sapiens	39-43
23485707-1	2013	Previous work showed that aquaporin 1 (AQP1), AQP4-M23, and AQP5 each has a characteristic CO(2)/NH(3) and CO(2)/H(2)O permeability ratio.	co(2)	107-112	aquaporin 4	Homo sapiens	46-50
23485707-1	2013	Previous work showed that aquaporin 1 (AQP1), AQP4-M23, and AQP5 each has a characteristic CO(2)/NH(3) and CO(2)/H(2)O permeability ratio.	co(2)	107-112	aquaporin 5	Homo sapiens	60-64
23434661-7	2013	This indicates that the CO(2) separation performance of the CMCS/PEI blend membrane is higher than that of other facilitated transport membranes reported for CO(2)/N(2) mixture separation.	co(2)	24-29	G protein signaling modulator 2	Homo sapiens	60-64
23434661-7	2013	This indicates that the CO(2) separation performance of the CMCS/PEI blend membrane is higher than that of other facilitated transport membranes reported for CO(2)/N(2) mixture separation.	co(2)	158-163	G protein signaling modulator 2	Homo sapiens	60-64
23373792-7	2013	RESULTS: The temperature at the pulp side after the CO(2) laser irradiation increased 22.5 C. The expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1-alpha mRNAs was significantly higher at 6, 12, and 24 h after laser irradiation than in the control group (p<0.05).	co(2)	52-57	tumor necrosis factor	Rattus norvegicus	112-139
23373792-7	2013	RESULTS: The temperature at the pulp side after the CO(2) laser irradiation increased 22.5 C. The expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1-alpha mRNAs was significantly higher at 6, 12, and 24 h after laser irradiation than in the control group (p<0.05).	co(2)	52-57	interleukin 1 alpha	Rattus norvegicus	156-180
23292932-6	2013	For instance, with CO(2) stabilized at 400-450 ppm (as required for the frequently quoted "acceptable warming" of 2  C), or even at AD 2011 levels of 392 ppm, we infer a likely (68% confidence) long-term sea-level rise of more than 9 m above the present.	co(2)	19-24	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	204-207
23292932-7	2013	Therefore, our results imply that to avoid significantly elevated sea level in the long term, atmospheric CO(2) should be reduced to levels similar to those of preindustrial times.	co(2)	106-111	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	66-69
23261285-2	2013	The main advantage of the developed detector is its capability to introduce full column effluent up to 2000 mL min(-1) CO(2) gas directly into the IMS cell relative to 40 mL min(-1) CO(2) gas as a maximum tolerance, reported for the previous IMS detectors.	co(2)	119-124	CD59 molecule (CD59 blood group)	Homo sapiens	111-117
23148319-7	2013	By contrast, suppression of hypercapnia sensitivity was associated with down-regulation of two key mediators of CO(2) sensing, i.e. carbonic anhydrase I and II.	co(2)	112-117	carbonic anhydrase 1	Rattus norvegicus	132-159
23261285-2	2013	The main advantage of the developed detector is its capability to introduce full column effluent up to 2000 mL min(-1) CO(2) gas directly into the IMS cell relative to 40 mL min(-1) CO(2) gas as a maximum tolerance, reported for the previous IMS detectors.	co(2)	182-187	CD59 molecule (CD59 blood group)	Homo sapiens	174-180
22809020-4	2013	The methanogenic pathway was determined by following the production of (14) CH(4) and (14) CO(2) from acetate labeled in the methyl group (C-2).	co(2)	91-96	complement C2	Homo sapiens	139-142
23249245-1	2013	High selectivity and low-energy regeneration for adsorption of CO(2) gas were achieved concurrently in a two-dimensional Cu(II) porous coordination polymer, [Cu(PF(6))(2)(4,4"-bpy)(2)](n) (4,4"-bpy = 4,4"-bipyridine), containing inorganic fluorinated PF(6)(-) anions that can act as moderate interaction sites for CO(2) molecules.	co(2)	63-68	sperm associated antigen 17	Homo sapiens	161-166
23249245-1	2013	High selectivity and low-energy regeneration for adsorption of CO(2) gas were achieved concurrently in a two-dimensional Cu(II) porous coordination polymer, [Cu(PF(6))(2)(4,4"-bpy)(2)](n) (4,4"-bpy = 4,4"-bipyridine), containing inorganic fluorinated PF(6)(-) anions that can act as moderate interaction sites for CO(2) molecules.	co(2)	63-68	sperm associated antigen 17	Homo sapiens	251-256
23249245-1	2013	High selectivity and low-energy regeneration for adsorption of CO(2) gas were achieved concurrently in a two-dimensional Cu(II) porous coordination polymer, [Cu(PF(6))(2)(4,4"-bpy)(2)](n) (4,4"-bpy = 4,4"-bipyridine), containing inorganic fluorinated PF(6)(-) anions that can act as moderate interaction sites for CO(2) molecules.	co(2)	314-319	sperm associated antigen 17	Homo sapiens	161-166
23301595-2	2013	Extensive gas-sorption studies in representative and important MOFs functionalized with free aromatic -OH groups such as the IRMOF-8 and DUT-6 (or MOF-205), denoted here as 1 and 2, revealed a high CO(2)/CH(4) selectivity for 1 (13.6 at 273 K and 1 bar) and a high NH(3) uptake of 16.4 mol kg(-1) at 298 K and 1 bar for 2.	co(2)	198-203	prostaglandin D2 receptor	Homo sapiens	170-180
23200251-1	2013	Mutation of amino acid residues 94, 96 and 119 to histidine(s) in the human carbonic anhydrase (CA, EC 4.2.1.1) related proteins CARP VIII, X and XI restored the zinc binding and catalytic activity for the hydration of CO(2) to bicarbonate.	co(2)	219-224	cytochrome c oxidase subunit 8A	Homo sapiens	134-138
23124131-8	2013	RESULTS: CO(2) incubation was associated with an increase in ROS production (p < 0.01), cell DNA damage mainly after 24 h (12 % increase of tail DNA content and 4-fold increase of tail length) and a significant up-regulation in p53 expression at 24 h with an intense nuclear staining.	co(2)	9-14	tumor protein p53	Homo sapiens	231-234
23441111-2	2013	METHODS: TE-HCE reconstruction was performed by culturing 1,1"-dioctadecyl-3,3,3",3"-tetramethylindocarbocyanine perchlorate (DiI)-labeled monoclonal HCE cells on denuded amniotic membranes (dAMs) in 20% fetal bovine serum-containing Dulbecco"s Modified Eagle"s Medium/Ham"s Nutrient Mixture F12 (1:1) medium and 5% CO(2) at 37   C on a 24-well culture plate.	co(2)	316-321	RNA guanylyltransferase and 5'-phosphatase	Homo sapiens	12-15
23124131-9	2013	In CO(2)-treated cells, we observed an S-phase arrest in correlation with a reduction of cyclin B1 expression.	co(2)	3-8	cyclin B1	Homo sapiens	89-98
23124131-10	2013	CONCLUSIONS: In vitro-simulated pneumoperitoneum environment with CO(2) induces oxidative stress and cell DNA damage, leading to p53 up-regulation involved in cell-cycle arrest of neuroblastoma cells.	co(2)	66-71	tumor protein p53	Homo sapiens	129-132
23441228-1	2013	Carbonic anhydrase (CA) IX is a transmembrane isozyme of CAs that catalyzes reversible hydration of CO(2).	co(2)	100-105	carbonic anhydrase 9	Homo sapiens	0-26
23359632-4	2013	The MOF presents exceptionally high uptake capacity not only for CO(2) but also for H(2), which is attributed to favorable interactions between the gas molecules and the nitrogen-rich triazole units of the MOF proved by both experimental measurements and theoretical molecular simulations.	co(2)	65-70	lysine acetyltransferase 8	Homo sapiens	4-7
23359632-4	2013	The MOF presents exceptionally high uptake capacity not only for CO(2) but also for H(2), which is attributed to favorable interactions between the gas molecules and the nitrogen-rich triazole units of the MOF proved by both experimental measurements and theoretical molecular simulations.	co(2)	65-70	lysine acetyltransferase 8	Homo sapiens	206-209
23205912-1	2012	In the presence of 1.1 equiv of PhMe(2)Si-Bpin, 5 equiv of CsF, and 20 mol % of TsOH H(2)O, precursors of N-Boc-imines can be converted into the corresponding alpha-aryl or alpha-alkenyl glycine derivatives under gaseous CO(2) in moderate-to-high yields with a single operation.	co(2)	221-226	colony stimulating factor 2	Homo sapiens	59-62
23121122-6	2012	The 3D network is stable up to 425  C and is permanently porous to CO(2) with an apparent BET surface area of 523(8) m(2)/g (p/p  = 0.02-0.22).	co(2)	67-72	delta/notch like EGF repeat containing	Homo sapiens	90-93
23054991-1	2012	Cocrystals of itraconazole, an antifungal drug with poor bioavailability, and succinic acid, a water-soluble dicarboxylic acid, were formed by gas antisolvent (GAS) cocrystallization using pressurized CO(2) to improve itraconazole dissolution.	co(2)	201-206	gastrin	Homo sapiens	143-146
23124663-7	2012	RESULTS: Measurements of standard CO(2) gas and atmospheric CO(2) yield reproducibility of 0.01 to 0.03 % for both delta(17)O and delta(18)O values, and 5 per meg for (17)O(excess).	co(2)	34-39	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	159-162
23124663-7	2012	RESULTS: Measurements of standard CO(2) gas and atmospheric CO(2) yield reproducibility of 0.01 to 0.03 % for both delta(17)O and delta(18)O values, and 5 per meg for (17)O(excess).	co(2)	60-65	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	159-162
23054991-1	2012	Cocrystals of itraconazole, an antifungal drug with poor bioavailability, and succinic acid, a water-soluble dicarboxylic acid, were formed by gas antisolvent (GAS) cocrystallization using pressurized CO(2) to improve itraconazole dissolution.	co(2)	201-206	gastrin	Homo sapiens	160-163
23207750-3	2012	RESULTS: The use of CO(2) for arthroscopy causes an acute and mild synovitis alike to the liquid capsular distension, showing similar synovial fluid increase of leukocytes, TP, and TNF-alpha.	co(2)	20-25	tumor necrosis factor	Equus caballus	181-190
22149727-8	2012	A higher level of TGF-beta1 expression was seen at day 7 post-surgery and a lower level at day 14 post-surgery in the CO(2) laser wounds than in the scalpel and Er,Cr:YSGG laser wounds.	co(2)	118-123	transforming growth factor beta-1 proprotein	Cavia porcellus	18-27
22984778-5	2012	We show that dopamine, octopamine and serotonin receptor genes are expressed in the ovaries of queens, and that natural mating, CO(2) narcosis, and the presence of semen in the spermatheca differentially affect their expression.	co(2)	128-133	serotonin receptor	Apis mellifera	38-56
23236250-4	2012	The activity-based ship emissions of NO(x), CO, HC, CO(2), SO(2), and PM(10) were estimated using derived vessel speed profiles, and results were compared with those using the speed limits of control zones.	co(2)	52-57	inositol polyphosphate-5-phosphatase D	Homo sapiens	19-23
23089063-8	2012	Uranyl nitrate in the converted mixture was extracted with supercritical CO(2) containing TBP.	co(2)	73-78	TATA-box binding protein	Homo sapiens	90-93
23161858-0	2012	PGR5-dependent cyclic electron transport around PSI contributes to the redox homeostasis in chloroplasts rather than CO(2) fixation and biomass production in rice.	co(2)	117-122	proton gradient regulation 5	Arabidopsis thaliana	0-4
23161858-7	2012	The CO(2) fixation rate was only slightly reduced in the PGR5 KD lines.	co(2)	4-9	proton gradient regulation 5	Arabidopsis thaliana	57-61
23098192-0	2012	Structural and kinetic effects on changes in the CO(2) binding pocket of human carbonic anhydrase II.	co(2)	49-54	carbonic anhydrase 2	Homo sapiens	79-100
22728982-5	2012	Residual TNT chip analysis showed greater TNT degradation in PBR soils (70%) and significantly higher metabolic rates (4.5 fold increase in cumulative CO(2) levels) than in PNC soils (30%).	co(2)	151-156	chromosome 16 open reading frame 82	Homo sapiens	9-12
23126533-2	2012	In previous work, a novel desublimation CO(2) capture process has been exploited making use of three free piston Stirling coolers (namely, SC-1, SC-2, and SC-3, respectively).	co(2)	40-45	transcription factor 19	Homo sapiens	139-143
23126533-2	2012	In previous work, a novel desublimation CO(2) capture process has been exploited making use of three free piston Stirling coolers (namely, SC-1, SC-2, and SC-3, respectively).	co(2)	40-45	trans-2,3-enoyl-CoA reductase	Homo sapiens	145-149
23098192-1	2012	This work examines the effect of perturbing the position of bound CO(2) in the active site of human carbonic anhydrase II (HCA II) on catalysis.	co(2)	66-71	carbonic anhydrase 2	Homo sapiens	100-121
23025280-5	2012	The changes in PSII abundance were accompanied with a lower capacity of photosynthetic CO(2) assimilation in sgr1 than Col-0 after return of plants to lighted conditions following 3 and 5 days of darkness.	co(2)	87-92	non-yellowing 1	Arabidopsis thaliana	109-113
23087685-16	2012	Accumulation of CO(2) in package head-space due to the enhanced growth of Leuconostoc spp.	co(2)	16-21	histocompatibility minor 13	Homo sapiens	86-89
22847022-3	2012	Compared with non-acclimated WT, the BnCBF17-OE grown at 20  C mimicked the effects of cold acclimation on WT B. napus with respect to compact dwarf phenotype and increased rates of light-saturated CO(2) assimilation and photosynthetic electron transport.	co(2)	198-203	dehydration-responsive element-binding protein 1B-like	Brassica napus	37-44
22847022-8	2012	Thus, BnCBF17-over-expression and cold acclimation maintain enhanced energy conversion efficiency and reduced sensitivity to feedback-limited photosynthesis during long-term growth of B. napus under elevated CO(2).	co(2)	208-213	dehydration-responsive element-binding protein 1B-like	Brassica napus	6-13
22901105-1	2012	BACKGROUND: CO(2) transoral laser surgery and radiotherapy are both recognized as acceptable treatments for early glottic squamous cell carcinoma (SCC) with similar rates of cure.	co(2)	12-17	serpin family B member 3	Homo sapiens	147-150
22857013-6	2012	In this Account, we outline our efforts to develop highly active Co(III)-based catalysts for the selective production of polycarbonates from the alternating copolymerization of CO(2) with epoxides.	co(2)	177-182	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	65-72
22857013-7	2012	Binary systems consisting of simple (salen)Co(III)X and a nucleophilic cocatalyst exhibited high activity under mild conditions even at 0.1 MPa CO(2) pressure and afforded copolymers with >99% carbonate linkages and a high regiochemical control (~95% head-to-tail content).	co(2)	144-149	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	46-49
22857013-8	2012	Discrete, one-component (salen)Co(III)X complexes bearing an appended quaternary ammonium salt or sterically hindered Lewis base showed excellent activity in the selectively alternating copolymerization of CO(2) with both aliphatic epoxides and cyclohexene oxide at high temperatures with low catalyst loading and/or low pressures of CO(2).	co(2)	206-211	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	34-37
22857013-8	2012	Discrete, one-component (salen)Co(III)X complexes bearing an appended quaternary ammonium salt or sterically hindered Lewis base showed excellent activity in the selectively alternating copolymerization of CO(2) with both aliphatic epoxides and cyclohexene oxide at high temperatures with low catalyst loading and/or low pressures of CO(2).	co(2)	334-339	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	34-37
22857013-9	2012	Binary or one-component catalysts based on unsymmetric multichiral Co(III) complexes facilitated the efficient enantioselective copolymerization of CO(2) with epoxides, providing aliphatic polycarbonates with >99% head-to-tail content.	co(2)	148-153	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	67-74
22857013-14	2012	The high activity and excellent regioselectivity observed in the epoxide ring-opening reactions results from epoxide activation through the moderate electrophilicity of the Co(III) ion, the fast insertion of CO(2) into the Co-O bond, and the facile dissociation of the propagating carboxylate species from the central metal ion.	co(2)	208-213	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	173-180
22930156-3	2012	Although conventional activation under reduced pressure leads to structural collapse, activation by flowing supercritical CO(2) yields a guest-free material with a BET surface area of 4461 m(2) g(-1).	co(2)	122-127	delta/notch like EGF repeat containing	Homo sapiens	164-167
22899824-2	2012	We examined whether peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) overexpression and a subsequent increase in mitochondrial content and function in rat primary hepatocytes (in vitro) and Sprague-Dawley rats (in vivo) would comprehensively alter mitochondrial lipid metabolism, including complete (CO(2)) and incomplete (acid-soluble metabolites) fatty acid oxidation (FAO), tricarboxylic acid cycle flux, and triacylglycerol (TAG) storage and export.	co(2)	332-337	PPARG coactivator 1 alpha	Rattus norvegicus	89-99
23101643-3	2012	In contrast, above VT(1), CO(2) is washed-out from the alkaline reserve due to the combined effect of the fall in PA(CO2) (because of hyperventilation) and in pH, and this helps maintaining acid-base balance.	co(2)	26-31	complement C2	Homo sapiens	117-120
22958098-3	2012	H(2)O@iso1 displays a long-range three-dimensional ferromagnetic ordering with a drastic variation of the critical temperature as a function of the guest molecule [T(C) < 2.0 K (CO(2)@iso1 and CH(4)@iso1) and T(C) = 6.5 (CH(3)OH@iso1) and 21.0 K (H(2)O@iso1)].	co(2)	181-186	eukaryotic translation initiation factor 1	Homo sapiens	196-206
22836012-6	2012	Immunohistochemistry identified cells expressing alpha-gustducin and PLC-beta2 at multiple cardiorespiratory and CO(2)/H(+) chemosensory sites, including rostral ventral medulla, facial, parapyramidal, solitary tract, hypoglossal and raphe nuclei.	co(2)	113-118	phospholipase C, beta 2	Rattus norvegicus	69-78
22836012-7	2012	In the medullary raphe, alpha-gustducin and PLC-beta2 were colocalized with a subpopulation of tryptophan hydroxylase (TPH)-immunoreactive serotonergic neurons, a subset of which has respiratory CO(2)/H(+) chemosensitivity.	co(2)	195-200	phospholipase C, beta 2	Rattus norvegicus	44-53
22836012-7	2012	In the medullary raphe, alpha-gustducin and PLC-beta2 were colocalized with a subpopulation of tryptophan hydroxylase (TPH)-immunoreactive serotonergic neurons, a subset of which has respiratory CO(2)/H(+) chemosensitivity.	co(2)	195-200	tryptophan hydroxylase 1	Rattus norvegicus	95-117
22836012-7	2012	In the medullary raphe, alpha-gustducin and PLC-beta2 were colocalized with a subpopulation of tryptophan hydroxylase (TPH)-immunoreactive serotonergic neurons, a subset of which has respiratory CO(2)/H(+) chemosensitivity.	co(2)	195-200	tryptophan hydroxylase 1	Rattus norvegicus	119-122
22762983-1	2012	We prepared tri-isocyanate reinforced graphene aerogel with a low bulk density (0.08g/cm(3)), high compressive failure strength (0.24MPa), and good adsorption ability towards crude oil (~169mg/g), through self-assembly of graphene under hydrothermal condition, tri-isocyanate reinforcement and subsequent supercritical CO(2) drying process.	co(2)	319-324	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	12-15
22924695-1	2012	Activation of the corrinoid [Fe-S] protein (CoFeSP), involved in reductive CO(2) conversion, requires the reduction of the Co(II) center by the [Fe-S] protein RACo, which according to the reduction potentials of the two proteins would correspond to an uphill electron transfer.	co(2)	75-80	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-129
22869008-5	2012	For example, reduction of CO(2) under visible light irradiation with the assistance of the anisotropic AgX:Ag nanoparticles yields as much as 100 mumol methanol in the products.	co(2)	26-31	UDP-N-acetylglucosamine pyrophosphorylase 1	Homo sapiens	103-106
22869008-4	2012	The calculation of bandgaps and band positions indicates the as-achieved AgX:Ag nanoparticles can be used as a class of potential photocatalyst for the reduction of CO(2).	co(2)	165-170	UDP-N-acetylglucosamine pyrophosphorylase 1	Homo sapiens	73-76
23009844-5	2012	Rca self-association regulates the CO(2) fixing activity of the enzyme Rubisco, directly affecting biomass accumulation in higher plants.	co(2)	35-40	ribulose bisphosphate carboxylase/oxygenase activase 2, chloroplastic	Gossypium hirsutum	0-3
22865659-9	2012	In situ IR spectroscopy showed that CO(2) is physisorbed on IFP-1-4 under dry conditions and that both CO(2) and H(2)O are physisorbed on IFP-1 under moist conditions.	co(2)	36-41	tripartite motif containing 34	Homo sapiens	60-65
22865659-9	2012	In situ IR spectroscopy showed that CO(2) is physisorbed on IFP-1-4 under dry conditions and that both CO(2) and H(2)O are physisorbed on IFP-1 under moist conditions.	co(2)	103-108	tripartite motif containing 34	Homo sapiens	138-143
22897687-3	2012	In contrast, addition of NO(g) to [Co(eta(2)-NO(2))(TC-5,5)] generates both cobalt mono- and dinitrosyl adducts, and addition of nitric oxide to [Co(eta(2)-NO(2))(TC-6,6)] converts this complex to the dicobalt tetranitrosyl species [Co(2)(NO)(4)(TC-6,6)].	co(2)	233-238	noggin	Homo sapiens	25-30
22806410-1	2012	We herein report an unusual CO(2) adsorption behavior in a fluoro-functionalized MOF {[Zn(SiF(6))(pyz)(2)] 2MeOH}(n) (1) with a 1D channel system, which is made up of pyrazine and SiF(6)(2-) moieties.	co(2)	28-33	lysine acetyltransferase 8	Homo sapiens	81-84
22864281-12	2012	Blunted in vivo stress response in LRP specimens, likely mediated by CO(2) insufflation but not by longer ischemia time, is manifested in the reduced expression of stress-response genes in these specimens.	co(2)	69-74	LDL receptor related protein 1	Homo sapiens	35-38
22829322-6	2012	The analysis also showed that cs26 under LD required more absorbed quanta per driven electron flux and fixed CO(2).	co(2)	109-114	cysteine synthase 26	Arabidopsis thaliana	30-34
22848123-0	2012	The absence of alternative oxidase AOX1A results in altered response of photosynthetic carbon assimilation to increasing CO(2) in Arabidopsis thaliana.	co(2)	121-126	alternative oxidase 1A	Arabidopsis thaliana	35-40
22800191-1	2012	DFT/BP86/TZVP and DFT/B3LYP/TZVP have been used to investigate systematically the reaction pathways associated with the H-transfer step, which is the rate-determining step of the reaction HCOO(-)   CO(2) + H(+) + 2e(-), as catalyzed by metalloenzyme formate dehydrogenase (FDH).	co(2)	198-203	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	250-271
22848123-7	2012	Gas exchange analysis revealed a lower net CO(2) assimilation rate (A) at high CO(2) concentrations in the aox1a mutant compared to wild type.	co(2)	43-48	alternative oxidase 1A	Arabidopsis thaliana	107-112
22848123-7	2012	Gas exchange analysis revealed a lower net CO(2) assimilation rate (A) at high CO(2) concentrations in the aox1a mutant compared to wild type.	co(2)	79-84	alternative oxidase 1A	Arabidopsis thaliana	107-112
22848123-9	2012	The aox1a mutant also exhibited a lower estimated rate of ribulose 1,5-bisphosphate regeneration, and the ribulose 1,5-bisphosphate content was lower at high CO(2) concentrations, suggesting an ATP limitation of the Calvin-Benson cycle.	co(2)	158-163	alternative oxidase 1A	Arabidopsis thaliana	4-9
22800191-1	2012	DFT/BP86/TZVP and DFT/B3LYP/TZVP have been used to investigate systematically the reaction pathways associated with the H-transfer step, which is the rate-determining step of the reaction HCOO(-)   CO(2) + H(+) + 2e(-), as catalyzed by metalloenzyme formate dehydrogenase (FDH).	co(2)	198-203	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	273-276
22692371-2	2012	The X-ray crystal structures of the [H(4)L   NO(3)] (CH(3)CN)(4) and [H(4)L   CF(3)CO(2)] (CH(3)CN)(2) salt complexes are also reported.	co(2)	83-88	H4 clustered histone 7	Homo sapiens	70-75
22712748-9	2012	We propose that three mechanisms were involved in C(4) expansion: the physiological advantage of C(4) grasses under low atmospheric CO(2) allowed them to invade C(3) grasslands; fire allowed grasses to invade forests; and the evolution of fire-resistant savanna trees expanded the climate space that savannas can invade.	co(2)	132-137	complement C4A (Rodgers blood group)	Homo sapiens	50-54
22712748-9	2012	We propose that three mechanisms were involved in C(4) expansion: the physiological advantage of C(4) grasses under low atmospheric CO(2) allowed them to invade C(3) grasslands; fire allowed grasses to invade forests; and the evolution of fire-resistant savanna trees expanded the climate space that savannas can invade.	co(2)	132-137	complement C4A (Rodgers blood group)	Homo sapiens	97-101
22709623-4	2012	This might indicate a participation of thylakoid Cah3 in the CO(2)-concentrating mechanism (CCM) of chloroplast and reflect the dysfunction of the CCM in the cia3 mutant.	co(2)	61-66	uncharacterized protein	Chlamydomonas reinhardtii	49-53
22709623-9	2012	The results support our hypothesis that CO(2) might be generated from HCO(3)(-) by Cah3 in the thylakoid lumen with the following CO(2) diffusion into the pyrenoid, where the CO(2) fixing Rubisco is located.	co(2)	40-45	uncharacterized protein	Chlamydomonas reinhardtii	83-87
22859731-8	2012	In an atmosphere containing CO(2), strain B10(T) could not produce methane from formate, acetate, trimethylamine, 2-butanol, 2-propanol, cyclopentanol, 2-pentanol, ethanol, 1-propanol or 2,3-butanediol.	co(2)	28-33	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	42-45
22723484-6	2012	Of the seven genes, qPCR analysis indicated that elevated CO(2) concentrations only had a significant but subtle effect on two genes, one important for early embryo patterning, Wnt8, and the other an integral component in spiculogenesis and biomineralization, SM30b.	co(2)	58-63	Wnt8 protein	Strongylocentrotus purpuratus	177-181
22450857-4	2012	The material is thermally robust and remains crystalline under high vacuum at 150  C. When desolvated, the solid has a CO(2) BET surface area of 1187 m(2) g(-1) and shows the highest reported uptake of both O(2) and H(2) at 77 K and 1 bar for a lanthanide-based coordination polymer.	co(2)	119-124	delta/notch like EGF repeat containing	Homo sapiens	125-128
22678955-12	2012	However, at P<1 atm, the gas-adsorption capacities for N(2) at 77 K and CO(2) at 195 K are higher for noninterpenetrated SNU-70" than for interpenetrated SNU-71", but the capacities for H(2) and CH(4) are the opposite; SNU-71" has higher uptake capacities than SNU-70" due to the higher isosteric heat of gas adsorption that results from the smaller pores.	co(2)	75-80	RNA binding motif protein 25	Homo sapiens	157-163
22679919-5	2012	This increase of CO(2) adsorption capacity after chemical activation was due to an increase of BET surface area and pore volume in all carbon materials.	co(2)	17-22	delta/notch like EGF repeat containing	Homo sapiens	95-98
22582114-8	2012	Our findings are consistent with a preventive effect of therapeutic hypercapnia with 7% CO(2) on bleomycin-induced PHT via attenuation of macrophage-derived TNF-alpha.	co(2)	88-93	tumor necrosis factor	Rattus norvegicus	157-166
22723484-7	2012	Protein levels of another spicule matrix component, SM50, demonstrated significant variable responses to elevated CO(2).	co(2)	114-119	50 kDa spicule matrix protein	Strongylocentrotus purpuratus	52-56
22521817-2	2012	Phox2b-expressing neurons in the retrotrapezoid nucleus (RTN) respond to high CO(2)/H(+) stimulation and have been suggested to play an important role in central chemoreception.	co(2)	78-83	paired-like homeobox 2b	Rattus norvegicus	0-6
22404138-10	2012	We hypothesize that mitochondrial-associated class-2 PEPC facilitates rapid refixation of respiratory CO(2) while sustaining a large anaplerotic flux to replenish tricarboxylic acid cycle C-skeletons withdrawn for biosynthesis.	co(2)	102-107	phosphoenolpyruvate carboxylase	Nicotiana tabacum	53-57
22616945-6	2012	Peak CO(2) conversion occurred at -1 V (vs RHE) with approximately 100% efficiency and a rate 7-700 times higher than that for larger Au catalysts and 10-100 times higher than those for current state-of-the-art processes.	co(2)	5-10	factor interacting with PAPOLA and CPSF1	Homo sapiens	43-46
22505643-5	2012	Compared with hypoxia alone, animals exposed to hypoxia and 10% CO(2) had significantly (P < 0.05) decreased pulmonary vascular resistance, right-ventricular systolic pressure, right-ventricular hypertrophy, and medial wall thickness of pulmonary resistance arteries as well as decreased lung phosphodiesterase (PDE) V, RhoA, and ROCK activity.	co(2)	64-69	ras homolog family member A	Rattus norvegicus	323-327
22522511-3	2012	Magnetic investigation indicates that besides strong spin-orbit coupling of Co(II) ions, ferromagnetic and weak ferromagnetic exchange interactions between Co(II) ions in the Co(2) and Co(3) clusters exist in 1 and 2, respectively.	co(2)	175-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-162
22711428-0	2012	Oxytocin interference in the effects induced by inhalation of 7.5% CO(2)  in healthy volunteers.	co(2)	67-72	oxytocin/neurophysin I prepropeptide	Homo sapiens	0-8
22453138-3	2012	Recent evidence has demonstrated that wake-promoting hypothalamic orexin (ORX: also known as hypocretin) neurons are highly sensitive to local changes in CO(2)/H(+), and mice lacking prepro-ORX have blunted respiratory responses to hypercapnia.	co(2)	154-159	hypocretin	Mus musculus	66-72
22453138-3	2012	Recent evidence has demonstrated that wake-promoting hypothalamic orexin (ORX: also known as hypocretin) neurons are highly sensitive to local changes in CO(2)/H(+), and mice lacking prepro-ORX have blunted respiratory responses to hypercapnia.	co(2)	154-159	hypocretin	Mus musculus	93-103
22521817-7	2012	Our findings suggested that the location of Phox2b-ir neurons, including preinspiratory neurons of the pFRG, matched their role as sensors of blood CO(2) concentration.	co(2)	148-153	paired-like homeobox 2b	Rattus norvegicus	44-50
22462778-0	2012	Screening of CO(2) laser (10.6 mum) parameters for prevention of enamel erosion.	co(2)	13-18	latexin	Homo sapiens	31-34
22514282-2	2012	In vivo analysis has indicated that base J synthesis is initiated by the hydroxylation of thymidine by proteins (JBP1 and JBP2) homologous to the Fe(2+)/2-oxoglutarate (2-OG)-dependent dioxygenase superfamily where hydroxylation is driven by the oxidative decarboxylation of 2-OG, forming succinate and CO(2).	co(2)	303-308	protein arginine methyltransferase 5	Homo sapiens	113-117
22402433-2	2012	In the present article, CO(2) clusters (n = 6 to 13) are studied at the MP2 level of theory.	co(2)	24-29	tryptase pseudogene 1	Homo sapiens	72-75
22462778-1	2012	OBJECTIVE: The aim of this study was to screen CO(2) laser (10.6 mum) parameters to increase enamel resistance to a continuous-flow erosive challenge.	co(2)	47-52	latexin	Homo sapiens	65-68
22411009-5	2012	We also examine the possible contribution of P2Y1 receptors expressed in the RTN to the purinergic drive to breathe.We show that purinergic signalling contributes, in part, to the CO(2)/H+ sensitivity of RTN neurons.	co(2)	180-185	purinergic receptor P2Y1	Rattus norvegicus	45-49
22150826-0	2012	The Arabidopsis aquaporin PIP1;2 rules cellular CO(2)  uptake.	co(2)	48-53	plasma membrane intrinsic protein 1A	Arabidopsis thaliana	26-30
22150826-3	2012	Data obtained on a AtPIP1;2 T-DNA insertion line indicated that under these conditions, cellular CO(2) transport was not limited by unstirred layer effects but was dependent on the expression of the aquaporin AtPIP1;2.	co(2)	97-102	plasma membrane intrinsic protein 1A	Arabidopsis thaliana	19-25
22150826-3	2012	Data obtained on a AtPIP1;2 T-DNA insertion line indicated that under these conditions, cellular CO(2) transport was not limited by unstirred layer effects but was dependent on the expression of the aquaporin AtPIP1;2.	co(2)	97-102	plasma membrane intrinsic protein 1B	Arabidopsis thaliana	19-27
22150826-4	2012	Complementation of the AtPIP1;2 knockout restored membrane CO(2) transport levels to that of controls.	co(2)	59-64	plasma membrane intrinsic protein 1B	Arabidopsis thaliana	23-31
22530949-6	2012	A second phase transition to a P2(1)/n phase has been found, which is a slight modification of the low-pressure structure (Co(2)Si-related structure).	co(2)	123-128	cyclin dependent kinase inhibitor 1A	Homo sapiens	31-36
22189377-3	2012	From these experiments and others conducted by the same authors it is found that less compaction of waste or active mixing during the fire--"stirring"--promotes better combustion (as evidenced by lower CO/CO(2) ratio) and reduces emissions of PCDD/PCDF/PCB; an intuitive but previously undemonstrated result.	co(2)	205-210	pyruvate carboxylase	Homo sapiens	253-256
22189377-4	2012	These experiments also support previous results suggesting PCDD/PCDF/PCB generation in open burning - while still highly variable - tends to be greater in the later (smoldering) phases of burning when the CO/CO(2) ratio increases.	co(2)	208-213	pyruvate carboxylase	Homo sapiens	69-72
21879351-7	2012	The results of this study may imply that progressive decline in partial CO(2) pressure (hypocapnia) that develops during prolonged exercise may contribute to increased interleukin-6 production.	co(2)	72-77	interleukin 6	Homo sapiens	168-181
21769865-9	2012	Ten seconds shear stress stimulation also produced stress strength-dependent CO(2) gas excretion from the HPAoEC, which was significantly reduced by the inhibition of F(1)/F(O) ATP synthase or CA IV on the endothelial cell (EC) surface.	co(2)	77-82	carbonic anhydrase 4	Homo sapiens	193-198
22442146-1	2012	Isocitrate dehydrogenase (IDH) is a reversible enzyme that catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (ICT) to alpha-ketoglutarate (alphaKG) and the NADPH/CO(2)-dependent reductive carboxylation of alphaKG to ICT.	co(2)	184-189	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-24
22442146-1	2012	Isocitrate dehydrogenase (IDH) is a reversible enzyme that catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (ICT) to alpha-ketoglutarate (alphaKG) and the NADPH/CO(2)-dependent reductive carboxylation of alphaKG to ICT.	co(2)	184-189	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	26-29
22038163-5	2012	In particular, tumor necrosis factor-alpha (TNF-alpha) protein expression was significantly reduced (p < 0.05) following CO(2) pneumoperitoneum compared with laparotomy procedures.	co(2)	124-129	tumor necrosis factor	Rattus norvegicus	15-42
22351634-9	2012	Removing CO(2)/HCO(3)(-) inhibited acetylcholine-induced NO-mediated relaxations in arteries from NHE1 knockout but not wild-type mice.	co(2)	9-14	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	98-102
22351634-12	2012	Under physiological conditions, CO(2)/HCO(3)(-)-dependent mechanisms mask the pH(i)-regulatory function of NHE1.	co(2)	32-37	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	107-111
22455795-2	2012	In solution, these compounds were found to be in equilibrium with their corresponding imidazol(in)ium carboxylates, referred to as N-heterocyclic carbene (NHC)-CO(2) adducts.	co(2)	160-165	high mobility group nucleosomal binding domain 4	Homo sapiens	131-153
22455795-2	2012	In solution, these compounds were found to be in equilibrium with their corresponding imidazol(in)ium carboxylates, referred to as N-heterocyclic carbene (NHC)-CO(2) adducts.	co(2)	160-165	high mobility group nucleosomal binding domain 4	Homo sapiens	155-158
22284914-6	2012	The corresponding value (at 60 muM MO) for the porous sc-CO(2) dried fibers was 140 min over 240 min for the AEROXIDE( ) TiO(2) P25 as documented in the literature.	co(2)	57-62	tubulin polymerization promoting protein	Homo sapiens	128-131
22439902-7	2012	The presence of oxygen promotes NO and HNCO formation for all the three amino acids; HCN and HNCO formation are suppressed by introduced CO(2) for all the three amino acids.	co(2)	137-142	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	85-88
22038163-6	2012	Interleukin (IL)-6 protein expression was accordingly, markedly reduced (p < 0.05) following CO(2) pneumoperitoneum.	co(2)	96-101	interleukin 6	Rattus norvegicus	0-18
22038163-5	2012	In particular, tumor necrosis factor-alpha (TNF-alpha) protein expression was significantly reduced (p < 0.05) following CO(2) pneumoperitoneum compared with laparotomy procedures.	co(2)	124-129	tumor necrosis factor	Rattus norvegicus	44-53
22092659-5	2012	cbbM genes were not expressed in the oxygen-amended groundwater, probably due to the low CO(2) /O(2)  substrate specificity of this enzyme.	co(2)	89-94	opsin 1, medium wave sensitive	Homo sapiens	0-4
22462861-1	2012	An isotopic-independent, highly accurate potential energy surface (PES) has been determined for CO(2) by refining a purely ab initio PES with selected, purely experimentally determined rovibrational energy levels.	co(2)	96-101	pescadillo ribosomal biogenesis factor 1	Homo sapiens	67-70
22222221-1	2012	An amide-inserted metal-organic framework (NJU-Bai3) presents high storage and high selectivity toward CO(2) and combines these two interesting characters which strongly support our expectation that amide groups can significantly enhance the CO(2) binding ability and selectivity of MOFs.	co(2)	103-108	adhesion G protein-coupled receptor B3	Homo sapiens	47-51
22222221-1	2012	An amide-inserted metal-organic framework (NJU-Bai3) presents high storage and high selectivity toward CO(2) and combines these two interesting characters which strongly support our expectation that amide groups can significantly enhance the CO(2) binding ability and selectivity of MOFs.	co(2)	242-247	adhesion G protein-coupled receptor B3	Homo sapiens	47-51
22321216-0	2012	Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) fixation.	co(2)	119-124	p21 (RAC1) activated kinase 3	Homo sapiens	98-102
22623841-13	2012	CONCLUSION: RBC transfusion was effective in improving anemia, oxygenation, increasing pH, and decreasing CO(2) and Ca(+2).	co(2)	106-111	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	12-15
21818540-4	2012	Here we describe for the first time the effect of CO(2) laser stimulation at the acupoints Neiguan (PC-6), Quchi (LI-11), Zusanli (ST-36), and Taichong (LR-3) on heart rate and mean arterial blood pressure in anesthetized rats.	co(2)	50-55	proprotein convertase subtilisin/kexin type 5	Rattus norvegicus	100-104
21818540-5	2012	CO(2) laser stimulation increased the skin surface temperature to 54 C. Our results revealed that the laser stimulation at the left or right PC-6 and LR-3 increased heart rate and mean arterial pressure.	co(2)	0-5	proprotein convertase subtilisin/kexin type 5	Rattus norvegicus	141-145
21818540-10	2012	These results suggest that CO(2) laser stimulation at either the left or right PC-6, ST-36, and LR-3, as well as at the right LI-11 can modulate the cardiovascular functions in anesthetized rats, and its modulatory site might be supraspinal.	co(2)	27-32	proprotein convertase subtilisin/kexin type 5	Rattus norvegicus	79-83
22447686-6	2012	Allelic aae3 mutants lacked oxalyl-CoA synthetase activity and were unable to degrade oxalate into CO(2).	co(2)	99-104	AMP-dependent synthetase and ligase family protein	Arabidopsis thaliana	8-12
21410714-7	2012	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) represents a central step in CO(2)  reduction and in carbohydrate oxidation involving both forms of energy, namely NAD(P)H and ATP, with its various isoforms that are located in plastids, cytosol and nucleus.	co(2)	78-83	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	0-40
21410714-7	2012	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) represents a central step in CO(2)  reduction and in carbohydrate oxidation involving both forms of energy, namely NAD(P)H and ATP, with its various isoforms that are located in plastids, cytosol and nucleus.	co(2)	78-83	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	42-47
22306777-6	2012	Incubation of Neuro2A cells in a hypoxic chamber (1% O(2), 5% CO(2)) increased the level of LAMP-2A and induced accumulation of LAMP-2A-positive lysosomes in the perinuclear area, which is a hallmark of CMA activation.	co(2)	62-67	lysosomal-associated membrane protein 2	Mus musculus	92-99
22306777-6	2012	Incubation of Neuro2A cells in a hypoxic chamber (1% O(2), 5% CO(2)) increased the level of LAMP-2A and induced accumulation of LAMP-2A-positive lysosomes in the perinuclear area, which is a hallmark of CMA activation.	co(2)	62-67	lysosomal-associated membrane protein 2	Mus musculus	128-135
22242905-5	2012	All the adsorbents displayed good thermal stability at 200  C. Among them, MIP1b, with the higher amine content, exhibited the largest CO(2) capacity, which maintained steady after 50 adsorption-desorption cycles.	co(2)	135-140	C-C motif chemokine ligand 4	Homo sapiens	75-80
22121503-2	2012	Here we designed a nitrogen-rich trefoil hexacarboxylate (trigonal tri-isophthalate) ligand, which serves to act as the trigonal molecular building block while concurrently coding the formation of the targeted truncated cuboctahedral supermolecular building block (in situ), and enhancing the CO(2) uptake in the resultant rht-MOF.	co(2)	293-298	lysine acetyltransferase 8	Homo sapiens	327-330
22172219-3	2012	SGC case series of 9 patients who were treated with endoscopic marsupialization with cold steel instruments or CO(2) laser and mechanical decompression with balloon dilatation are presented.	co(2)	111-116	sarcoglycan beta	Homo sapiens	0-3
22195982-1	2012	The CO(2) fixation ability of N-heterocyclic carbenes (NHC) has been assessed on the basis of electronic and steric properties of the N- and C-substituents, measured in terms of molecular electrostatic potential minimum, observed at the carbene lone pair region of NHC (V(min1)) as well as at the carboxylate region of the NHC-CO(2) adduct (V(min2)).	co(2)	4-9	CD59 molecule (CD59 blood group)	Homo sapiens	272-276
22195982-1	2012	The CO(2) fixation ability of N-heterocyclic carbenes (NHC) has been assessed on the basis of electronic and steric properties of the N- and C-substituents, measured in terms of molecular electrostatic potential minimum, observed at the carbene lone pair region of NHC (V(min1)) as well as at the carboxylate region of the NHC-CO(2) adduct (V(min2)).	co(2)	4-9	CD59 molecule (CD59 blood group)	Homo sapiens	343-347
22071158-8	2012	Finally, chronic induction of HO-1 increases oxygen consumption, CO(2), and heat production and activity in obese mice.	co(2)	65-70	heme oxygenase 1	Mus musculus	30-34
22408724-11	2012	Our analyses point to the increased concentration of atmospheric CO(2) as the most likely global driver of indiscriminate rain forest expansion occurring in northeastern Australia, by increasing tree growth and thereby overriding the effects of fire disturbance.	co(2)	65-70	Ras interacting protein 1	Homo sapiens	122-126
23185291-10	2012	A follow-up study using Arabidopsis mutants for flowering time genes within the significant QTL suggests MOTHER OF FT AND TFL1 (MFT) as a potential candidate gene for altered flowering time at elevated [CO(2)].	co(2)	203-208	PEBP (phosphatidylethanolamine-binding protein) family protein	Arabidopsis thaliana	122-126
22848216-0	2012	Estimation of Insulin Resistance in Mexican Adults by the [(13)C]Glucose Breath Test Corrected for Endogenous Total CO(2) Production.	co(2)	116-121	insulin	Homo sapiens	14-21
22253597-3	2012	Here, we demonstrate that CA expression is tightly controlled by the availability of CO(2) and identify the bZIP transcription factor Rca1p as the first CO(2) regulator of CA expression in yeast.	co(2)	85-90	m-AAA protease subunit YTA12	Saccharomyces cerevisiae S288C	134-139
23056407-1	2012	Elevated CO(2) levels (hypercapnia) occur in patients with respiratory diseases and impair alveolar epithelial integrity, in part, by inhibiting Na,K-ATPase function.	co(2)	9-14	Na pump alpha subunit	Drosophila melanogaster	145-156
23056407-2	2012	Here, we examined the role of c-Jun N-terminal kinase (JNK) in CO(2) signaling in mammalian alveolar epithelial cells as well as in diptera, nematodes and rodent lungs.	co(2)	63-68	mitogen-activated protein kinase 8	Homo sapiens	30-53
23056407-2	2012	Here, we examined the role of c-Jun N-terminal kinase (JNK) in CO(2) signaling in mammalian alveolar epithelial cells as well as in diptera, nematodes and rodent lungs.	co(2)	63-68	mitogen-activated protein kinase 8	Homo sapiens	55-58
23056407-3	2012	In alveolar epithelial cells, elevated CO(2) levels rapidly induced activation of JNK leading to downregulation of Na,K-ATPase and alveolar epithelial dysfunction.	co(2)	39-44	mitogen-activated protein kinase 8	Homo sapiens	82-85
23056407-3	2012	In alveolar epithelial cells, elevated CO(2) levels rapidly induced activation of JNK leading to downregulation of Na,K-ATPase and alveolar epithelial dysfunction.	co(2)	39-44	Na pump alpha subunit	Drosophila melanogaster	115-126
23056407-5	2012	Importantly, elevated CO(2) levels also caused a rapid and prominent activation of JNK in Drosophila S2 cells and in C. elegans.	co(2)	22-27	basket	Drosophila melanogaster	83-86
23056407-6	2012	Paralleling the results with mammalian epithelial cells, RNAi against Drosophila JNK fully prevented CO(2)-induced downregulation of Na,K-ATPase in Drosophila S2 cells.	co(2)	101-106	basket	Drosophila melanogaster	81-84
23056407-6	2012	Paralleling the results with mammalian epithelial cells, RNAi against Drosophila JNK fully prevented CO(2)-induced downregulation of Na,K-ATPase in Drosophila S2 cells.	co(2)	101-106	Na pump alpha subunit	Drosophila melanogaster	133-144
23056407-7	2012	The importance and specificity of JNK CO(2) signaling was additionally demonstrated by the ability of mutations in the C. elegans JNK homologs, jnk-1 and kgb-2 to partially rescue the hypercapnia-induced fertility defects but not the pharyngeal pumping defects.	co(2)	38-43	mitogen-activated protein kinase 8	Homo sapiens	34-37
23056407-7	2012	The importance and specificity of JNK CO(2) signaling was additionally demonstrated by the ability of mutations in the C. elegans JNK homologs, jnk-1 and kgb-2 to partially rescue the hypercapnia-induced fertility defects but not the pharyngeal pumping defects.	co(2)	38-43	mitogen-activated protein kinase 8	Homo sapiens	130-133
23056407-7	2012	The importance and specificity of JNK CO(2) signaling was additionally demonstrated by the ability of mutations in the C. elegans JNK homologs, jnk-1 and kgb-2 to partially rescue the hypercapnia-induced fertility defects but not the pharyngeal pumping defects.	co(2)	38-43	Stress-activated protein kinase jnk-1	Caenorhabditis elegans	144-149
23056407-7	2012	The importance and specificity of JNK CO(2) signaling was additionally demonstrated by the ability of mutations in the C. elegans JNK homologs, jnk-1 and kgb-2 to partially rescue the hypercapnia-induced fertility defects but not the pharyngeal pumping defects.	co(2)	38-43	Stress-activated protein kinase JNK	Caenorhabditis elegans	154-159
23056407-8	2012	Together, these data provide evidence that deleterious effects of hypercapnia are mediated by JNK which plays an evolutionary conserved, specific role in CO(2) signaling in mammals, diptera and nematodes.	co(2)	154-159	mitogen-activated protein kinase 8	Homo sapiens	94-97
22272266-6	2012	Furthermore, PGC-1alpha enhanced mitochondrial oxidation of palmitate and lactate to CO(2), but not glucose oxidation.	co(2)	85-90	PPARG coactivator 1 alpha	Homo sapiens	13-23
23139834-3	2012	However this enzyme has also been frequently proposed to perform a critical function in inorganic carbon acquisition and CO(2) fixation and all mutants lacking Cah3 exhibit very poor growth after transfer to low CO(2) conditions.	co(2)	121-126	uncharacterized protein	Chlamydomonas reinhardtii	160-164
23139834-3	2012	However this enzyme has also been frequently proposed to perform a critical function in inorganic carbon acquisition and CO(2) fixation and all mutants lacking Cah3 exhibit very poor growth after transfer to low CO(2) conditions.	co(2)	212-217	uncharacterized protein	Chlamydomonas reinhardtii	160-164
23139834-4	2012	RESULTS/CONCLUSIONS: In the present work we demonstrate that after transfer to low CO(2), Cah3 is phosphorylated and that phosphorylation is correlated to changes in its localization and its increase in activity.	co(2)	83-88	uncharacterized protein	Chlamydomonas reinhardtii	90-94
23139834-5	2012	When C. reinhardtii wild-type cells were acclimated to limiting CO(2) conditions, the Cah3 activity increased about 5-6 fold.	co(2)	64-69	uncharacterized protein	Chlamydomonas reinhardtii	86-90
23139834-9	2012	In vivo phosphorylation analysis of thylakoid polypeptides indicates that there was a 3-fold increase in the phosphorylation signal of the Cah3 polypeptide within the first two hours after transfer to low CO(2) conditions.	co(2)	205-210	uncharacterized protein	Chlamydomonas reinhardtii	139-143
23139834-11	2012	Under high CO(2) conditions, the Cah3 protein was only associated with the donor side of PSII in the stroma thylakoids.	co(2)	11-16	uncharacterized protein	Chlamydomonas reinhardtii	33-37
22253597-3	2012	Here, we demonstrate that CA expression is tightly controlled by the availability of CO(2) and identify the bZIP transcription factor Rca1p as the first CO(2) regulator of CA expression in yeast.	co(2)	153-158	m-AAA protease subunit YTA12	Saccharomyces cerevisiae S288C	134-139
22253597-7	2012	Our results present the bZIP protein Rca1p as the first fungal regulator of carbonic anhydrase, and reveal the existence of an adenylyl cyclase independent CO(2) sensing pathway in yeast.	co(2)	156-161	m-AAA protease subunit YTA12	Saccharomyces cerevisiae S288C	37-42
22253597-8	2012	Rca1p appears to regulate cellular metabolism in response to CO(2) availability in environments as diverse as the phagosome, yeast communities or liquid culture.	co(2)	61-66	m-AAA protease subunit YTA12	Saccharomyces cerevisiae S288C	0-5
21883287-4	2011	The expression of a constitutively active form of ROP2 (CA-rop2) in Arabidopsis thaliana and Vicia faba resulted in slower and reduced stomatal closure in response to abscisic acid (ABA) and CO(2) .	co(2)	191-196	RHO-related protein from plants 2	Arabidopsis thaliana	50-54
22783113-6	2011	The discovery of PAL enzyme in fungi and the detection of (14)CO(2) production from (14)C-ring-labeled phenylalanine and cinnamic acid demonstrated that certain fungi can degrade phenylalanine by a pathway involving an initial deamination to cinnamic acid, as happens in plants.	co(2)	62-67	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	17-20
22119036-7	2012	INCA-C also predicts possible increases in dissolved inorganic carbon in some tributaries with rising temperature suggesting increased CO(2) emissions from rivers as climate changes.	co(2)	135-140	caspase recruitment domain family member 17	Homo sapiens	0-4
21976482-8	2011	Unlike the individual shm1 and shm2 null mutants, which require CO(2)-enriched air to inhibit photorespiration (shm1) or do not show any visible impairment (shm2), double-null mutants cannot survive in CO(2)-enriched air.	co(2)	64-69	serine transhydroxymethyltransferase 1	Arabidopsis thaliana	112-116
21883287-4	2011	The expression of a constitutively active form of ROP2 (CA-rop2) in Arabidopsis thaliana and Vicia faba resulted in slower and reduced stomatal closure in response to abscisic acid (ABA) and CO(2) .	co(2)	191-196	RHO-related protein from plants 2	Arabidopsis thaliana	59-63
21974953-1	2011	Glutaryl-CoA dehydrogenase catalyzes the oxidative decarboxylation of the gamma-carboxylate of the substrate, glutaryl-CoA, to yield crotonyl-CoA and CO(2).	co(2)	150-155	glutaryl-CoA dehydrogenase	Rattus norvegicus	0-26
22270627-6	2011	Similarly, CO(2) hydration occurs with an efficiency within ~500-fold of CAII.	co(2)	11-16	carbonic anhydrase 2	Homo sapiens	73-77
22049409-6	2011	We identify common target molecules of miR-279 and Pros in bioinformatics analysis, and show that overexpression of the transcription factors Nerfin-1 and Escargot (Esg) is sufficient to induce formation of CO(2) neurons on maxillary palps.	co(2)	207-212	escargot	Drosophila melanogaster	155-163
22049409-5	2011	We use a combination of genetics and in vitro and in vivo analysis to demonstrate that Pros participates in the regulation of miR-279 expression, and that reexpression of miR-279 rescues the pros CO(2) neuron phenotype.	co(2)	196-201	mir-279 stem loop	Drosophila melanogaster	171-178
22049409-6	2011	We identify common target molecules of miR-279 and Pros in bioinformatics analysis, and show that overexpression of the transcription factors Nerfin-1 and Escargot (Esg) is sufficient to induce formation of CO(2) neurons on maxillary palps.	co(2)	207-212	escargot	Drosophila melanogaster	165-168
22049409-7	2011	Our results suggest that Prospero restricts CO(2) neuron formation indirectly via miR-279 and directly by repressing the shared target molecules, Nerfin-1 and Esg, during olfactory system development.	co(2)	44-49	prospero	Drosophila melanogaster	25-33
22049409-5	2011	We use a combination of genetics and in vitro and in vivo analysis to demonstrate that Pros participates in the regulation of miR-279 expression, and that reexpression of miR-279 rescues the pros CO(2) neuron phenotype.	co(2)	196-201	prospero	Drosophila melanogaster	191-195
22049409-6	2011	We identify common target molecules of miR-279 and Pros in bioinformatics analysis, and show that overexpression of the transcription factors Nerfin-1 and Escargot (Esg) is sufficient to induce formation of CO(2) neurons on maxillary palps.	co(2)	207-212	mir-279 stem loop	Drosophila melanogaster	39-46
22049409-6	2011	We identify common target molecules of miR-279 and Pros in bioinformatics analysis, and show that overexpression of the transcription factors Nerfin-1 and Escargot (Esg) is sufficient to induce formation of CO(2) neurons on maxillary palps.	co(2)	207-212	prospero	Drosophila melanogaster	51-55
21903582-3	2011	Cells exposed to elevated CO(2) died in galactose medium as well as when glucose-6-phosphate isomerase was knocked down, suggesting mitochondrial dysfunction.	co(2)	26-31	glucose-6-phosphate isomerase	Homo sapiens	73-102
22049409-6	2011	We identify common target molecules of miR-279 and Pros in bioinformatics analysis, and show that overexpression of the transcription factors Nerfin-1 and Escargot (Esg) is sufficient to induce formation of CO(2) neurons on maxillary palps.	co(2)	207-212	nervous fingers 1	Drosophila melanogaster	142-150
22128120-1	2011	In the late 1960s, a vibrant new research field was ignited by the discovery that instead of fixing CO(2) into a C(3) compound, some plants initially fix CO(2) into a four-carbon (C(4)) compound.	co(2)	100-105	complement C3	Homo sapiens	113-117
22128120-1	2011	In the late 1960s, a vibrant new research field was ignited by the discovery that instead of fixing CO(2) into a C(3) compound, some plants initially fix CO(2) into a four-carbon (C(4)) compound.	co(2)	154-159	complement C4A (Rodgers blood group)	Homo sapiens	180-184
21903582-6	2011	Also, overexpression of miR-183 decreased IDH2 (mRNA and protein) as well as cell proliferation under normocapnic conditions, whereas inhibition of miR-183 rescued the normal proliferation phenotype in cells exposed to elevated levels of CO(2).	co(2)	238-243	microRNA 183	Homo sapiens	24-31
21903582-6	2011	Also, overexpression of miR-183 decreased IDH2 (mRNA and protein) as well as cell proliferation under normocapnic conditions, whereas inhibition of miR-183 rescued the normal proliferation phenotype in cells exposed to elevated levels of CO(2).	co(2)	238-243	microRNA 183	Homo sapiens	148-155
21903582-7	2011	Accordingly, we provide evidence that high CO(2) induces miR-183, which down-regulates IDH2, thus impairing mitochondrial function and cell proliferation.	co(2)	43-48	microRNA 183	Homo sapiens	57-64
21903582-7	2011	Accordingly, we provide evidence that high CO(2) induces miR-183, which down-regulates IDH2, thus impairing mitochondrial function and cell proliferation.	co(2)	43-48	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	87-91
21643882-10	2011	RESULTS: After 21 days, perifilamental infiltration with macrophages (CD68) and percentage of proliferating cells (Ki67) were highest after 6 mmHg of CO(2) pneumoperitoneum.	co(2)	150-155	macrosialin	Oryctolagus cuniculus	70-74
21915411-8	2011	The relationship between their structural conformation and the underlying mechanisms for the CO(2) absorption behavior were investigated by employing NMR and ATR FT-IR spectroscopies.	co(2)	93-98	ATR serine/threonine kinase	Homo sapiens	158-161
21903582-4	2011	High CO(2) levels led to increased levels of microRNA-183 (miR-183), which in turn decreased expression of IDH2 (isocitrate dehydrogenase 2).	co(2)	5-10	microRNA 183	Homo sapiens	45-57
21903582-4	2011	High CO(2) levels led to increased levels of microRNA-183 (miR-183), which in turn decreased expression of IDH2 (isocitrate dehydrogenase 2).	co(2)	5-10	microRNA 183	Homo sapiens	59-66
21903582-4	2011	High CO(2) levels led to increased levels of microRNA-183 (miR-183), which in turn decreased expression of IDH2 (isocitrate dehydrogenase 2).	co(2)	5-10	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	107-111
21903582-5	2011	The high CO(2)-induced decrease in cell proliferation was rescued by alpha-ketoglutarate and overexpression of IDH2, whereas proliferation decreased in normocapnic cells transfected with siRNA for IDH2.	co(2)	9-14	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	111-115
21903582-5	2011	The high CO(2)-induced decrease in cell proliferation was rescued by alpha-ketoglutarate and overexpression of IDH2, whereas proliferation decreased in normocapnic cells transfected with siRNA for IDH2.	co(2)	9-14	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	197-201
21913686-3	2011	Here we present evidence that the biological buffer bicarbonate/CO(2) potentiates the ability of H(2)O(2) to inactivate PTPs.	co(2)	64-69	6-pyruvoyltetrahydropterin synthase	Homo sapiens	120-124
21822520-3	2011	High-pressure CO(2) and CH(4) adsorption measurement at 298 K reveals that activated 1 can absorb 45.8 cm(3) (STP)/g CO(2) at 22 atm and 22.5 cm(3) (STP)/g CH(4) at 25 atm.	co(2)	14-19	thyroid hormone receptor interactor 10	Homo sapiens	110-113
21842912-1	2011	Free neutral CO(2) clusters were produced by adiabatic expansion and characterized by carbon 1s (C1s) photoelectron spectroscopy using synchrotron radiation.	co(2)	13-18	complement C1s	Homo sapiens	97-100
21822520-3	2011	High-pressure CO(2) and CH(4) adsorption measurement at 298 K reveals that activated 1 can absorb 45.8 cm(3) (STP)/g CO(2) at 22 atm and 22.5 cm(3) (STP)/g CH(4) at 25 atm.	co(2)	117-122	thyroid hormone receptor interactor 10	Homo sapiens	110-113
21822505-1	2011	In this study we attempt to investigate the potential use of two zeolite template carbon (ZTC), EMT-ZTC and FAU-ZTC, to capture CO(2) at room temperature.	co(2)	128-133	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	108-111
21822505-2	2011	We report their high pressure CO(2) adsorption isotherms (273 K) that show for FAU-ZTC the highest carbon capture capacity among published carbonaceous materials and competitive data with the best organic and inorganic adsorbing frameworks ever-known (zeolites and mesoporous silicas, COFs and MOFs).	co(2)	30-35	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	79-82
21799973-2	2011	In this report, two sonochemical methods (S1 and S2) were used to prepare highly dispersed Ru catalysts supported on mesoporous TiO(2) (TiO(2)(MSP)) for the PROX reaction, in which a reaction gas mixture containing 1% CO + 1% O(2) + 18% CO(2) + 78% H(2) was used.	co(2)	237-242	macrophage stimulating 1	Homo sapiens	136-147
21815618-3	2011	At each temperature, tau(r) increased almost linearly with increasing viscosity, eta, in both CH(3)CN and CO(2); however, tau(r) in CO(2) at near critical densities deviated appreciably upward, as shown in a similar analogue of bis(acetylacetonato)beryllium(II), [Be(acac)(2)] (Umecky; et al.	co(2)	106-111	endothelin receptor type A	Homo sapiens	81-84
21815618-3	2011	At each temperature, tau(r) increased almost linearly with increasing viscosity, eta, in both CH(3)CN and CO(2); however, tau(r) in CO(2) at near critical densities deviated appreciably upward, as shown in a similar analogue of bis(acetylacetonato)beryllium(II), [Be(acac)(2)] (Umecky; et al.	co(2)	132-137	endothelin receptor type A	Homo sapiens	81-84
21799973-4	2011	The Ru/TiO(2)(MSP) catalysts were active for the PROX reaction below 200  C and good for the methanation reactions of CO and CO(2) above 200  C. The presence of residual chlorine in the catalysts severely suppressed their PROX reaction activity, and a higher dispersion of Ru particles led to better catalytic performances.	co(2)	125-130	macrophage stimulating 1	Homo sapiens	7-18
21823579-9	2011	Furthermore, DUT-30(Zn) exhibits a hydrogen storage capacity of 1.12 wt % at 1 bar, a CO(2) uptake of 200 cm(3) g(-1) at -78  C and 0.9 bar, and a n-butane uptake of 3.0 mmol g(-1) at 20  C. The N(2) adsorption process was monitored in situ via X-ray powder diffraction using synchrotron radiation.	co(2)	86-91	deoxyuridine triphosphatase	Homo sapiens	13-16
21780744-4	2011	High pressure small-angle neutron scattering (HP-SANS) measurements of reversed micelle formation in CO(2) show a clear relationship between F content and CO(2) compatibility of any given surfactant.	co(2)	101-106	USH1 protein network component sans	Homo sapiens	49-53
21780744-4	2011	High pressure small-angle neutron scattering (HP-SANS) measurements of reversed micelle formation in CO(2) show a clear relationship between F content and CO(2) compatibility of any given surfactant.	co(2)	155-160	USH1 protein network component sans	Homo sapiens	49-53
21409559-2	2011	The limiting-CO(2)-inducible gene, LCIB, encodes a soluble plastid protein and is proposed to play a role in trapping CO(2) released by CAH3 (thylakoid lumen carbonic anhydrase) catalyzed dehydration of accumulated Ci, especially in low CO(2) (L-CO(2); ~0.04% CO(2)) conditions.	co(2)	13-18	uncharacterized protein	Chlamydomonas reinhardtii	35-39
21307341-5	2011	The Mecp2-null mice showed a selective loss of their respiratory response to 1-3% CO(2) (mild hypercapnia), whereas they displayed more regular breathing in response to 6-9% CO(2) (severe hypercapnia).	co(2)	82-87	methyl CpG binding protein 2	Mus musculus	4-9
21307341-7	2011	Consistent with the in vivo observations, in vitro studies in brain slices indicated that CO(2) chemosensitivity of locus coeruleus (LC) neurons was impaired in Mecp2-null mice.	co(2)	90-95	methyl CpG binding protein 2	Mus musculus	161-166
21243526-2	2011	We previously observed very high production of the H43/Fea1 protein under high-CO(2) (0.3-3% in air) conditions.	co(2)	79-84	uncharacterized protein	Chlamydomonas reinhardtii	55-59
21243526-4	2011	To elucidate the regulatory mechanism of H43/Fea1 expression, this study intended to identify a high-CO(2)-responsive cis-element in a wall-deficient strain C. reinhardtti CC-400.	co(2)	101-106	uncharacterized protein	Chlamydomonas reinhardtii	45-49
21243526-5	2011	Cells incubated in the presence of acetate in the dark, namely heterotrophically generated high-CO(2) conditions, were used for inducing H43/Fea1 gene expression following our previous study (Hanawa et al., Plant Cell Physiol 48:299-309, 2007) in Fe-sufficient and Cd-deficient medium to prevent the generation of other signals.	co(2)	96-101	uncharacterized protein	Chlamydomonas reinhardtii	141-145
21567290-7	2011	Rates of photosynthesis under photorespiratory conditions (ambient CO(2) and O(2) concentrations) were slightly reduced in the hpr1 and pmdh1pmdh2hpr1 plants indicating other reactions can help bypass this disruption in the photorespiratory pathway.	co(2)	67-72	nuclear matrix protein-like protein	Arabidopsis thaliana	127-131
21567290-9	2011	Measurements of Gamma*, the CO(2) compensation point in the absence of mitochondrial respiration, and the CO(2) released per Rubisco oxygenation reaction demonstrated that the increase in Gamma in the hpr1 and pmdh1pmdh2hpr1 plants is not associated with changes in mitochondrial respiration but with an increase in the non-respiratory CO(2) released per Rubisco oxygenation reaction.	co(2)	28-33	nuclear matrix protein-like protein	Arabidopsis thaliana	201-205
21567290-9	2011	Measurements of Gamma*, the CO(2) compensation point in the absence of mitochondrial respiration, and the CO(2) released per Rubisco oxygenation reaction demonstrated that the increase in Gamma in the hpr1 and pmdh1pmdh2hpr1 plants is not associated with changes in mitochondrial respiration but with an increase in the non-respiratory CO(2) released per Rubisco oxygenation reaction.	co(2)	106-111	nuclear matrix protein-like protein	Arabidopsis thaliana	201-205
21567290-9	2011	Measurements of Gamma*, the CO(2) compensation point in the absence of mitochondrial respiration, and the CO(2) released per Rubisco oxygenation reaction demonstrated that the increase in Gamma in the hpr1 and pmdh1pmdh2hpr1 plants is not associated with changes in mitochondrial respiration but with an increase in the non-respiratory CO(2) released per Rubisco oxygenation reaction.	co(2)	106-111	nuclear matrix protein-like protein	Arabidopsis thaliana	201-205
21715674-6	2011	This could be explained by C(4) plants having higher COS concentrations at the CA site (maintaining high A(s) with reduced CA) and a high phosphoenolpyruvate carboxylase/CA activity ratio (reducing (18)O exchange efficiency between CO(2) and water, but not A(s)).	co(2)	232-237	complement C4A (Rodgers blood group)	Homo sapiens	27-31
21715674-6	2011	This could be explained by C(4) plants having higher COS concentrations at the CA site (maintaining high A(s) with reduced CA) and a high phosphoenolpyruvate carboxylase/CA activity ratio (reducing (18)O exchange efficiency between CO(2) and water, but not A(s)).	co(2)	232-237	phosphoenolpyruvate carboxykinase 1	Homo sapiens	138-169
21243526-7	2011	Consequently, the high-CO(2)-responsive cis-element (HCRE) was found to be located at a -537/-370 upstream region from the transcriptional initiation site of H43/Fea1.	co(2)	23-28	uncharacterized protein	Chlamydomonas reinhardtii	162-166
21243526-10	2011	These results clearly showed that H43/Fea1 expression is regulated by high-CO(2) signal independently via the HCRE that is located distantly from Fe-deficient-signal responsive element, indicating that H43/Fea1 is a multi-signal-regulated gene.	co(2)	75-80	uncharacterized protein	Chlamydomonas reinhardtii	38-42
21243526-10	2011	These results clearly showed that H43/Fea1 expression is regulated by high-CO(2) signal independently via the HCRE that is located distantly from Fe-deficient-signal responsive element, indicating that H43/Fea1 is a multi-signal-regulated gene.	co(2)	75-80	uncharacterized protein	Chlamydomonas reinhardtii	206-210
21409559-2	2011	The limiting-CO(2)-inducible gene, LCIB, encodes a soluble plastid protein and is proposed to play a role in trapping CO(2) released by CAH3 (thylakoid lumen carbonic anhydrase) catalyzed dehydration of accumulated Ci, especially in low CO(2) (L-CO(2); ~0.04% CO(2)) conditions.	co(2)	13-18	uncharacterized protein	Chlamydomonas reinhardtii	136-140
21409559-2	2011	The limiting-CO(2)-inducible gene, LCIB, encodes a soluble plastid protein and is proposed to play a role in trapping CO(2) released by CAH3 (thylakoid lumen carbonic anhydrase) catalyzed dehydration of accumulated Ci, especially in low CO(2) (L-CO(2); ~0.04% CO(2)) conditions.	co(2)	118-123	uncharacterized protein	Chlamydomonas reinhardtii	35-39
21409559-2	2011	The limiting-CO(2)-inducible gene, LCIB, encodes a soluble plastid protein and is proposed to play a role in trapping CO(2) released by CAH3 (thylakoid lumen carbonic anhydrase) catalyzed dehydration of accumulated Ci, especially in low CO(2) (L-CO(2); ~0.04% CO(2)) conditions.	co(2)	118-123	uncharacterized protein	Chlamydomonas reinhardtii	136-140
21409559-2	2011	The limiting-CO(2)-inducible gene, LCIB, encodes a soluble plastid protein and is proposed to play a role in trapping CO(2) released by CAH3 (thylakoid lumen carbonic anhydrase) catalyzed dehydration of accumulated Ci, especially in low CO(2) (L-CO(2); ~0.04% CO(2)) conditions.	co(2)	118-123	uncharacterized protein	Chlamydomonas reinhardtii	35-39
21409559-2	2011	The limiting-CO(2)-inducible gene, LCIB, encodes a soluble plastid protein and is proposed to play a role in trapping CO(2) released by CAH3 (thylakoid lumen carbonic anhydrase) catalyzed dehydration of accumulated Ci, especially in low CO(2) (L-CO(2); ~0.04% CO(2)) conditions.	co(2)	118-123	uncharacterized protein	Chlamydomonas reinhardtii	136-140
21409559-2	2011	The limiting-CO(2)-inducible gene, LCIB, encodes a soluble plastid protein and is proposed to play a role in trapping CO(2) released by CAH3 (thylakoid lumen carbonic anhydrase) catalyzed dehydration of accumulated Ci, especially in low CO(2) (L-CO(2); ~0.04% CO(2)) conditions.	co(2)	118-123	uncharacterized protein	Chlamydomonas reinhardtii	35-39
21409559-2	2011	The limiting-CO(2)-inducible gene, LCIB, encodes a soluble plastid protein and is proposed to play a role in trapping CO(2) released by CAH3 (thylakoid lumen carbonic anhydrase) catalyzed dehydration of accumulated Ci, especially in low CO(2) (L-CO(2); ~0.04% CO(2)) conditions.	co(2)	118-123	uncharacterized protein	Chlamydomonas reinhardtii	136-140
21409559-2	2011	The limiting-CO(2)-inducible gene, LCIB, encodes a soluble plastid protein and is proposed to play a role in trapping CO(2) released by CAH3 (thylakoid lumen carbonic anhydrase) catalyzed dehydration of accumulated Ci, especially in low CO(2) (L-CO(2); ~0.04% CO(2)) conditions.	co(2)	118-123	uncharacterized protein	Chlamydomonas reinhardtii	35-39
21409559-2	2011	The limiting-CO(2)-inducible gene, LCIB, encodes a soluble plastid protein and is proposed to play a role in trapping CO(2) released by CAH3 (thylakoid lumen carbonic anhydrase) catalyzed dehydration of accumulated Ci, especially in low CO(2) (L-CO(2); ~0.04% CO(2)) conditions.	co(2)	118-123	uncharacterized protein	Chlamydomonas reinhardtii	136-140
21409559-8	2011	Also, the interactions between lcib mutations and each of the three suppressors varied over the range of CO(2) acclimation states.	co(2)	105-110	uncharacterized protein	Chlamydomonas reinhardtii	31-35
21409559-9	2011	Our results suggest complex contributions of LCIB-dependent and independent active Ci uptake/accumulation systems in various CO(2) acclimation states and therefore provide new clues about the roles played by LCIB in limiting Ci acclimation.	co(2)	125-130	uncharacterized protein	Chlamydomonas reinhardtii	45-49
21772074-0	2011	CdO-based nanostructures as novel CO(2) gas sensors.	co(2)	34-39	cell adhesion associated, oncogene regulated	Homo sapiens	0-3
21772074-7	2011	The results obtained demonstrate that CdO-based thick films have good potential as novel CO(2) sensors for practical applications.	co(2)	89-94	cell adhesion associated, oncogene regulated	Homo sapiens	38-41
21775811-1	2011	The experimental charge-density distribution of the dinuclear cobalt(II) complex [Co(2)(sym-hmp)(2)](BPh(4))(2) 2H(2)O 2C(3)H(6)O was determined at 100 K. When decreasing the temperature, the magnetic susceptibility of this complex deviates from Curie law because of anti-ferromagnetic exchange interactions, but the susceptibility increases sharply at low temperature (< 20 K).	co(2)	82-87	inner membrane mitochondrial protein	Homo sapiens	92-95
21477123-9	2011	Both elevated CO(2) and NAA application increased expressions of caprice, triptychon and rho-related protein from plants 2, and decreased expressions of werewolf, GLABRA2, GLABRA3 and the transparent testa glabra 1, genes related to root-hair development, while 1-NOA and NPA application had an opposite effect.	co(2)	14-19	HD-ZIP IV family of homeobox-leucine zipper protein with lipid-binding START domain-containing protein	Arabidopsis thaliana	163-170
21680606-4	2011	Proteomic analysis data showed that the levels of 22 of 129 extracellular proteins increased for 1 and 3 d and such multiple high-CO(2)-inducible proteins include gametogenesis-related proteins and hydroxyproline-rich glycoproteins.	co(2)	130-135	uncharacterized protein	Chlamydomonas reinhardtii	93-104
21477123-9	2011	Both elevated CO(2) and NAA application increased expressions of caprice, triptychon and rho-related protein from plants 2, and decreased expressions of werewolf, GLABRA2, GLABRA3 and the transparent testa glabra 1, genes related to root-hair development, while 1-NOA and NPA application had an opposite effect.	co(2)	14-19	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	172-179
21477123-9	2011	Both elevated CO(2) and NAA application increased expressions of caprice, triptychon and rho-related protein from plants 2, and decreased expressions of werewolf, GLABRA2, GLABRA3 and the transparent testa glabra 1, genes related to root-hair development, while 1-NOA and NPA application had an opposite effect.	co(2)	14-19	myb domain protein 0	Arabidopsis thaliana	206-214
22112270-3	2011	The acetyl-CoA carboxylase (ACC) enzyme catalyzes the addition of CO(2) to acetyl-CoA to generate malonyl-CoA.	co(2)	66-71	acetyl-CoA carboxyltransferase subunit alpha	Escherichia coli str. K-12 substr. MG1655	4-26
21806294-5	2011	We assessed the pulse duration dependence of the Hsp70 expression after irradiation with a CO(2) laser at 10.6 mum in wavelength over a range of 1000 to 1 ms. Hsp70 induction varied with changes in laser pulse durations and radiant exposures, which defined the ranges at which thermal activation of Hsp70 can be used to protect cells from subsequent stress, and reveals the window of thermal stress that tissues can endure.	co(2)	91-96	heat shock protein 1B	Mus musculus	49-54
21806294-5	2011	We assessed the pulse duration dependence of the Hsp70 expression after irradiation with a CO(2) laser at 10.6 mum in wavelength over a range of 1000 to 1 ms. Hsp70 induction varied with changes in laser pulse durations and radiant exposures, which defined the ranges at which thermal activation of Hsp70 can be used to protect cells from subsequent stress, and reveals the window of thermal stress that tissues can endure.	co(2)	91-96	heat shock protein 1B	Mus musculus	159-164
21806294-5	2011	We assessed the pulse duration dependence of the Hsp70 expression after irradiation with a CO(2) laser at 10.6 mum in wavelength over a range of 1000 to 1 ms. Hsp70 induction varied with changes in laser pulse durations and radiant exposures, which defined the ranges at which thermal activation of Hsp70 can be used to protect cells from subsequent stress, and reveals the window of thermal stress that tissues can endure.	co(2)	91-96	heat shock protein 1B	Mus musculus	159-164
21586649-4	2011	Plants overexpressing HSC70-1 or with reduced HSP90.2 activity are compromised in the dark-, CO(2)-, flagellin 22 peptide-, and abscisic acid (ABA)-induced stomatal closure.	co(2)	93-98	heat shock cognate protein 70-1	Arabidopsis thaliana	22-29
21592965-1	2011	Biotin carboxylase (BC) activity is shared among biotin-dependent carboxylases and catalyzes the Mg-ATP-dependent carboxylation of biotin using bicarbonate as the CO(2) donor.	co(2)	163-168	methylcrotonyl-CoA carboxylase subunit 2	Homo sapiens	0-18
21592965-1	2011	Biotin carboxylase (BC) activity is shared among biotin-dependent carboxylases and catalyzes the Mg-ATP-dependent carboxylation of biotin using bicarbonate as the CO(2) donor.	co(2)	163-168	methylcrotonyl-CoA carboxylase subunit 2	Homo sapiens	20-22
21333760-4	2011	Heart rate similarly differed only in female 5HTT nulls at P15 being decreased in both air and CO(2) (P<0.01).	co(2)	95-100	cyclin dependent kinase inhibitor 2B	Mus musculus	59-62
21333760-5	2011	Ventilation in air and 5% CO(2) was significant reduced via an effect on tidal volume at P15 (P<0.02) and P25 (P<0.05) but only in males.	co(2)	26-31	cyclin dependent kinase inhibitor 2B	Mus musculus	89-92
21333760-5	2011	Ventilation in air and 5% CO(2) was significant reduced via an effect on tidal volume at P15 (P<0.02) and P25 (P<0.05) but only in males.	co(2)	26-31	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	Mus musculus	109-112
21333760-6	2011	Ventilation in air and 5% CO(2) was greater in 5HTT null females at P25.	co(2)	26-31	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	Mus musculus	68-71
21333760-8	2011	586.9, 2321-2329, 2008) appears to have origins in early postnatal life (P15) when ventilation in both air and 5% CO(2) is reduced.	co(2)	114-119	cyclin dependent kinase inhibitor 2B	Mus musculus	73-76
21576376-5	2011	The nociceptor ion channel TRPA1 is activated by CO(2), through gating of the channel by intracellular protons, making it a candidate to more generally mediate sensory responses to weak acids.	co(2)	49-54	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	27-32
21430274-15	2011	Thus these results strongly suggest that the TRP channels are likely to play a role in the CO(2) chemosensitivity of LC neurons, especially TRPC5.	co(2)	91-96	transient receptor potential cation channel subfamily C member 5	Homo sapiens	140-145
21524275-2	2011	The critical role of PEPC in assimilating atmospheric CO(2) during C(4) and Crassulacean acid metabolism photosynthesis has been studied extensively.	co(2)	54-59	phosphoenolpyruvate carboxykinase 1	Homo sapiens	21-25
21524275-10	2011	The interaction between divergent PEPC polypeptides within Class-2 PEPCs adds another layer of complexity to the evolution, physiological functions and metabolic control of this essential CO(2)-fixing plant enzyme.	co(2)	188-193	phosphoenolpyruvate carboxykinase 1	Homo sapiens	34-38
21377354-4	2011	The option of pellet production integrated with the existing CHP plant with the exhaust flue gas and superheated steam as drying mediums has the lowest specific pellet production cost of 105 $/t(pellet), the shortest payback time of less than 2 years and the greatest CO(2) reduction of the three options.	co(2)	268-273	calcineurin like EF-hand protein 1	Homo sapiens	61-64
21435867-3	2011	Energy and CO(2) balances are carried out for a hypothetical integrated PBR-raceway microalgae-to-biodiesel production in Singapore.	co(2)	11-16	translocator protein	Homo sapiens	72-75
21335437-1	2011	C(4) plants established a mechanism for the concentration of CO(2) in the vicinity of ribulose-1,5-bisphosphate carboxylase/oxygenase in order to saturate the enzyme with substrate and substantially to reduce the alternative fixation of O(2) that results in energy losses.	co(2)	61-66	complement C4A (Rodgers blood group)	Homo sapiens	0-4
21423149-8	2011	Unexpectedly, OST1 loss-of-function alleles showed strongly impaired CO(2)-induced stomatal closing and HCO(3)(-) activation of anion channels.	co(2)	69-74	ribophorin I	Homo sapiens	14-18
21443859-8	2011	Moreover, PPARalpha activation increased the production of CO(2) and acid soluble metabolites, which are products of fatty acid oxidation, and increased oxygen consumption rate in human adipocytes.	co(2)	59-64	peroxisome proliferator activated receptor alpha	Homo sapiens	10-19
21387073-3	2011	The highly fluorous nature of the ligands affords the complexes good supercritical CO(2) solubility as measured by supercritical fluid extraction (SFE), and has allowed for the copolymerisation of CO and ethylene using [PdClMe(dfppp)] as the catalyst precursor and CO(2) as the solvent.	co(2)	83-88	membrane metalloendopeptidase	Homo sapiens	147-150
21446678-3	2011	The PFl-CO(2) presents a maximum emission at 418 nm, while the PPE-Th-CO(2) has an absorption lambda(max) centered at 431 nm, in sufficient proximity for effective FRET.	co(2)	8-13	profilin 2	Homo sapiens	4-7
21446678-7	2011	For films using the PAH/PMA system as buffer bilayers and deposited from 1 mM solutions, the PFl-CO(2) fluorescence is progressively recovered as the number of intervening buffer bilayers is increased.	co(2)	97-102	profilin 2	Homo sapiens	93-96
21413740-3	2011	It is shown that, as compared to B3LYP, the functional PBE yields geometrical and energetic data more close to those of MP2 for cation-CO(2) systems.	co(2)	135-140	tryptase pseudogene 1	Homo sapiens	120-123
21695026-3	2011	The analysis shows how use of these principles leads to quite different conclusions than those of most previous such economic analyses, as follows: The economic benefits of reducing CO(2) emissions may be about two orders of magnitude less than those estimated by most economists because the climate sensitivity factor (CSF) is much lower than assumed by the United Nations because feedback is negative rather than positive and the effects of CO(2) emissions reductions on atmospheric CO(2) appear to be short rather than long lasting.	co(2)	182-187	colony stimulating factor 2	Homo sapiens	292-318
21351767-3	2011	Among these functional PAFs, we found that tetrahydrofuran-like ether-functionalized PAF-1 shows higher adsorption capacity for CO(2) at 1 bar and 298 K (10 mol per kilogram of adsorbent) and also much higher selectivities for CO(2)/CH(4), CO(2)/N(2), and CO(2)/H(2) mixtures when compared with the amine functionality.	co(2)	128-133	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	85-90
21351767-3	2011	Among these functional PAFs, we found that tetrahydrofuran-like ether-functionalized PAF-1 shows higher adsorption capacity for CO(2) at 1 bar and 298 K (10 mol per kilogram of adsorbent) and also much higher selectivities for CO(2)/CH(4), CO(2)/N(2), and CO(2)/H(2) mixtures when compared with the amine functionality.	co(2)	227-232	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	85-90
21351767-3	2011	Among these functional PAFs, we found that tetrahydrofuran-like ether-functionalized PAF-1 shows higher adsorption capacity for CO(2) at 1 bar and 298 K (10 mol per kilogram of adsorbent) and also much higher selectivities for CO(2)/CH(4), CO(2)/N(2), and CO(2)/H(2) mixtures when compared with the amine functionality.	co(2)	227-232	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	85-90
21351767-3	2011	Among these functional PAFs, we found that tetrahydrofuran-like ether-functionalized PAF-1 shows higher adsorption capacity for CO(2) at 1 bar and 298 K (10 mol per kilogram of adsorbent) and also much higher selectivities for CO(2)/CH(4), CO(2)/N(2), and CO(2)/H(2) mixtures when compared with the amine functionality.	co(2)	227-232	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	85-90
21335533-2	2011	We report that the AGC kinase Sch9 prevents hypha formation specifically under hypoxia at high CO(2) levels.	co(2)	95-100	serine/threonine protein kinase SCH9	Saccharomyces cerevisiae S288C	30-34
21335533-3	2011	sch9 mutants showed no major defects in growth and stress resistance but a striking hyperfilamentous phenotype under hypoxia (<10% O(2)), although only in the presence of elevated CO(2) levels (>1%) and at temperatures of <37 C during surface growth.	co(2)	183-188	serine/threonine protein kinase SCH9	Saccharomyces cerevisiae S288C	0-4
21335533-6	2011	Transcriptomal analyses showed that Sch9 regulates most genes solely under hypoxia and in the presence of elevated CO(2).	co(2)	115-120	serine/threonine protein kinase SCH9	Saccharomyces cerevisiae S288C	36-40
21335533-9	2011	The results stress the importance of environmental conditions on Sch9 function and establish a novel response circuitry to both hypoxia and CO(2) in C. albicans, which suppresses hypha formation but also allows efficient nutrient uptake, metabolism, and virulence.	co(2)	140-145	serine/threonine protein kinase SCH9	Saccharomyces cerevisiae S288C	65-69
21255608-6	2011	Oxalate oxidase (OxOx) is a commonly occurring enzyme in plants, bacteria and fungi that catalyses oxidative cleavage of oxalate to CO(2) with reduction of dioxygen to H(2)O(2).	co(2)	132-137	germin-like protein 8-4	Triticum aestivum	0-15
21255608-6	2011	Oxalate oxidase (OxOx) is a commonly occurring enzyme in plants, bacteria and fungi that catalyses oxidative cleavage of oxalate to CO(2) with reduction of dioxygen to H(2)O(2).	co(2)	132-137	germin-like protein 8-4	Triticum aestivum	17-21
21695026-3	2011	The analysis shows how use of these principles leads to quite different conclusions than those of most previous such economic analyses, as follows: The economic benefits of reducing CO(2) emissions may be about two orders of magnitude less than those estimated by most economists because the climate sensitivity factor (CSF) is much lower than assumed by the United Nations because feedback is negative rather than positive and the effects of CO(2) emissions reductions on atmospheric CO(2) appear to be short rather than long lasting.	co(2)	182-187	colony stimulating factor 2	Homo sapiens	320-323
21695026-3	2011	The analysis shows how use of these principles leads to quite different conclusions than those of most previous such economic analyses, as follows: The economic benefits of reducing CO(2) emissions may be about two orders of magnitude less than those estimated by most economists because the climate sensitivity factor (CSF) is much lower than assumed by the United Nations because feedback is negative rather than positive and the effects of CO(2) emissions reductions on atmospheric CO(2) appear to be short rather than long lasting.	co(2)	443-448	colony stimulating factor 2	Homo sapiens	292-318
21695026-3	2011	The analysis shows how use of these principles leads to quite different conclusions than those of most previous such economic analyses, as follows: The economic benefits of reducing CO(2) emissions may be about two orders of magnitude less than those estimated by most economists because the climate sensitivity factor (CSF) is much lower than assumed by the United Nations because feedback is negative rather than positive and the effects of CO(2) emissions reductions on atmospheric CO(2) appear to be short rather than long lasting.	co(2)	443-448	colony stimulating factor 2	Homo sapiens	320-323
21695026-3	2011	The analysis shows how use of these principles leads to quite different conclusions than those of most previous such economic analyses, as follows: The economic benefits of reducing CO(2) emissions may be about two orders of magnitude less than those estimated by most economists because the climate sensitivity factor (CSF) is much lower than assumed by the United Nations because feedback is negative rather than positive and the effects of CO(2) emissions reductions on atmospheric CO(2) appear to be short rather than long lasting.	co(2)	443-448	colony stimulating factor 2	Homo sapiens	292-318
21695026-3	2011	The analysis shows how use of these principles leads to quite different conclusions than those of most previous such economic analyses, as follows: The economic benefits of reducing CO(2) emissions may be about two orders of magnitude less than those estimated by most economists because the climate sensitivity factor (CSF) is much lower than assumed by the United Nations because feedback is negative rather than positive and the effects of CO(2) emissions reductions on atmospheric CO(2) appear to be short rather than long lasting.	co(2)	443-448	colony stimulating factor 2	Homo sapiens	320-323
21366255-5	2011	Density functional theory estimates of rate and equilibrium constants show that the kinetically relevant O(2) activation steps involve direct O(2)* (or O(2)) reactions with CO* to form reactive O*-O-C*=O intermediates that decompose to form CO(2) and chemisorbed O*, instead of unassisted activation steps involving molecular adsorption and subsequent dissociation of O(2).	co(2)	241-246	immunoglobulin kappa variable 1D-39	Homo sapiens	105-109
20978518-4	2011	Systemic leptin administration for 1 week after occlusion surgery increased cerebral hemodynamic reserve similar to granulocyte-macrophage colony-stimulating factor (GM-CSF), as indicated by improved CO(2) reactivity (vehicle 0.53%+-0.26% versus leptin 1.05%+-0.6% per mm Hg arterial pCO(2), P<0.05).	co(2)	200-205	leptin	Rattus norvegicus	9-15
20978518-6	2011	Acute treatment with GM-CSF led to a significant increased CO(2) reactivity and cerebral perfusion (79.2%+-8.1% versus 64.9%+-4.5%, P<0.05).	co(2)	59-64	colony stimulating factor 2	Rattus norvegicus	21-27
21366255-5	2011	Density functional theory estimates of rate and equilibrium constants show that the kinetically relevant O(2) activation steps involve direct O(2)* (or O(2)) reactions with CO* to form reactive O*-O-C*=O intermediates that decompose to form CO(2) and chemisorbed O*, instead of unassisted activation steps involving molecular adsorption and subsequent dissociation of O(2).	co(2)	241-246	immunoglobulin kappa variable 1D-39	Homo sapiens	142-146
21366255-5	2011	Density functional theory estimates of rate and equilibrium constants show that the kinetically relevant O(2) activation steps involve direct O(2)* (or O(2)) reactions with CO* to form reactive O*-O-C*=O intermediates that decompose to form CO(2) and chemisorbed O*, instead of unassisted activation steps involving molecular adsorption and subsequent dissociation of O(2).	co(2)	241-246	immunoglobulin kappa variable 1D-39	Homo sapiens	142-146
21366255-5	2011	Density functional theory estimates of rate and equilibrium constants show that the kinetically relevant O(2) activation steps involve direct O(2)* (or O(2)) reactions with CO* to form reactive O*-O-C*=O intermediates that decompose to form CO(2) and chemisorbed O*, instead of unassisted activation steps involving molecular adsorption and subsequent dissociation of O(2).	co(2)	241-246	immunoglobulin kappa variable 1D-39	Homo sapiens	142-146
21319201-5	2011	High-fat diet CPT1A- and, to a greater extent, CPT1AM-expressing mice showed an enhanced hepatic FAO which resulted in increased production of CO(2) , adenosine triphosphate, and ketone bodies.	co(2)	143-148	carnitine palmitoyltransferase 1a, liver	Mus musculus	14-18
21377369-2	2011	The new enzyme, denominated lwCA, has a catalytic activity for the physiologic CO(2) hydration to bicarbonate reaction, similar to that of the high activity human isoform hCA II, with a k(cat) of 1.1x10(6) s(-1), and a k(cat)/K(m) of 1.4x10(8) M(-1) s(-1).	co(2)	79-84	carbonic anhydrase 2	Homo sapiens	171-177
21258723-4	2011	In contrast to alpha-1, which shows almost no CO(2) adsorption, alpha-1" adsorbs CO(2) gas with structural transformations, this being the first example that exhibits adsorption of gas in a dense Werner-type complex and a drastic change in adsorption properties depending on the size of the crystals.	co(2)	81-86	adrenoceptor alpha 1D	Homo sapiens	64-71
21282152-4	2011	As anthropogenic CO(2) permeates into the ocean, it is making sea water more acidic, to the detriment of surface corals and probably many other calcifiers.	co(2)	17-22	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	62-65
21282152-7	2011	A curious feedback in the ocean, carbonate compensation, makes it more likely that global warming and sea-level rise will continue for many millennia after CO(2) emissions cease.	co(2)	156-161	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	102-105
21314183-1	2011	When poly(isopropylidene diallylmalonate) rich in threo-disyndiotactic sequences (st(rich)-2) was utilized as a cross-linkable ink for microcontact printing, the resultant submicrometer-scale patterns featuring 700 and 300 nm wide stripes were successfully insolubilized while maintaining their high dimensional integrity by heat-induced cross-linking with elimination of CO(2) and acetone.	co(2)	372-377	Rho GTPase activating protein 44	Homo sapiens	82-92
21168968-5	2011	Combustion efficiency (eta(C)), which measures the tendency to convert organic carbon to CO(2), was also determined for all the amines, being eta(CA1)<eta(CA2)<eta(CA3)<eta(CA4)=0.99.	co(2)	89-94	endothelin receptor type A	Homo sapiens	23-26
21234597-10	2011	This CO(2)-sensitive Kir channel may hyperpolarize excitable cells and provides a potential mechanism for CO(2)-dependent inhibition during hypercapnia.	co(2)	5-10	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	21-24
21234597-10	2011	This CO(2)-sensitive Kir channel may hyperpolarize excitable cells and provides a potential mechanism for CO(2)-dependent inhibition during hypercapnia.	co(2)	106-111	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	21-24
20966190-6	2011	At P25, they had significantly lower ventilation (Ve) and Ve-to-Vo(2) ratios in both air and 7% CO(2).	co(2)	96-101	lipocalin 2	Rattus norvegicus	3-6
21131518-6	2011	When PDC2, a transcriptional regulator of pyruvate decarboxylase genes, was deleted to increase intracellular pyruvate levels and cells were grown under a CO(2) atmosphere to favor carboxylation, adaptive evolution yielded a strain that grew on glucose (specific growth rate, 0.06 +- 0.01 h(-1)).	co(2)	155-160	Pdc2p	Saccharomyces cerevisiae S288C	5-9
21131518-8	2011	Consistently, cytosolic relocalization of the native Mae1p, which can use both NADH and NADPH, in a pyc1,2Delta pdc2Delta strain grown under a CO(2) atmosphere, also enabled slow-growth on glucose.	co(2)	143-148	malate dehydrogenase (oxaloacetate-decarboxylating)	Saccharomyces cerevisiae S288C	53-58
20966190-7	2011	The ventilatory response to CO(2) (% increase in Ve/Vo(2)) was significantly increased at P5 (males) and reduced at P15 and P25 (males and females).	co(2)	28-33	cyclin-dependent kinase inhibitor 2B	Rattus norvegicus	116-127
20920536-1	2011	Carbonic anhydrase IX (CAIX) is a zinc metalloenzyme that catalyzes the reversible hydration of CO(2).	co(2)	96-101	carbonic anhydrase 9	Homo sapiens	0-21
20880205-3	2011	Strong anaerobic reporter gene activity in tobacco (Nicotiana tabacum) controlled by the glycolytic glyceraldehyde-3-phosphate dehydrogenase (GapC4) promoter from maize (Zea mays) depends on the presence of CO(2) and light.	co(2)	207-212	glyceraldehyde-3-phosphate dehydrogenase, cytosolic-like	Nicotiana tabacum	100-140
20880205-9	2011	Database assisted as well as experimental analysis reveal a role for AP2/EREBP transcription factors for conferring the high CO(2) specificity to the GapC4 promoter in tobacco leaves.	co(2)	125-130	ethylene-responsive transcription factor RAP2-3-like	Nicotiana tabacum	69-72
21211161-3	2011	The concentrations of CO(2) and CO are inferred from their wavelength modulation spectroscopy (WMS) 1f-normalized absorption-based WMS-2f signal peak heights.	co(2)	22-27	fibrillin 1	Homo sapiens	131-136
21116573-2	2011	In the case of [Co(3)Cl(6)(1)(2)] n(solvent) (TIF-1) which possesses a doubly interpenetrated framework structure, the material exhibits rigid, permanent porosity and selectively absorbs CO(2).	co(2)	187-192	tripartite motif containing 24	Homo sapiens	46-51
20920536-1	2011	Carbonic anhydrase IX (CAIX) is a zinc metalloenzyme that catalyzes the reversible hydration of CO(2).	co(2)	96-101	carbonic anhydrase 9	Homo sapiens	23-27
22073231-7	2011	Fusicoccin treatment, exposition to increasing light intensities, and supply of decreasing CO(2) concentrations demonstrated full opening capacity of nfxl2-1 stomata.	co(2)	91-96	NF-X1-type zinc finger protein NFXL2	Arabidopsis thaliana	150-155
21282740-3	2011	We investigated here whether CO(2) laser treatment induces hormesis in human gingival fibroblast (HGF) and oral squamous cell carcinoma (HSC-2) cells.	co(2)	29-34	hepatocyte growth factor	Homo sapiens	98-101
21799293-1	2011	The effect of hyperoxygenation with carbogen (95% O(2) + 5% CO(2)) inhalation on RIF-1 tumor pO(2 )and its consequence on growth inhibition with fractionated radiotherapy is reported.	co(2)	60-65	replication timing regulatory factor 1	Mus musculus	81-86
21098675-8	2011	Pulse-chase experiments with (14)CO(2) show that transport of assimilate in the flowering stem is much slower in gsl7 mutants than in wild-type plants.	co(2)	33-38	glucan synthase-like 7	Arabidopsis thaliana	113-117
20931209-5	2011	METHODS: The influence of CO(2) pneumoperitoneum on the gene expression of plasminogen activator inhibitor-1 (PAI-1), urokinase-type plasminogen activator (uPA), and tissue-type plasminogen activator (tPA) was investigated in colon carcinoma cell lines (HT116, SW48, and WiDr) and mesothelial cells employing a pneumoperitoneum chamber in vitro.	co(2)	26-31	serpin family E member 1	Homo sapiens	75-108
20931209-5	2011	METHODS: The influence of CO(2) pneumoperitoneum on the gene expression of plasminogen activator inhibitor-1 (PAI-1), urokinase-type plasminogen activator (uPA), and tissue-type plasminogen activator (tPA) was investigated in colon carcinoma cell lines (HT116, SW48, and WiDr) and mesothelial cells employing a pneumoperitoneum chamber in vitro.	co(2)	26-31	plasminogen activator, urokinase	Homo sapiens	118-154
20931209-7	2011	RESULTS: The expression of uPA and PAI-1 was increased in colon carcinoma cell lines when cultivated at pH 6.1, a value corresponding to intraabdominal pH values during CO(2) insufflation.	co(2)	169-174	plasminogen activator, urokinase	Homo sapiens	27-30
20931209-7	2011	RESULTS: The expression of uPA and PAI-1 was increased in colon carcinoma cell lines when cultivated at pH 6.1, a value corresponding to intraabdominal pH values during CO(2) insufflation.	co(2)	169-174	serpin family E member 1	Homo sapiens	35-40
20931209-8	2011	Elevated PAI-1 mRNA levels were also observed when CO(2) was simultaneously applied with a pressure of 10 mmHg.	co(2)	51-56	serpin family E member 1	Homo sapiens	9-14
20926613-12	2010	We conclude that RTN astrocytes sense CO(2)/H(+) in part by inhibition of a Kir4.1-Kir5.1-like current and may provide an excitatory purinergic drive to pH-sensitive neurons.	co(2)	38-43	potassium inwardly rectifying channel subfamily J member 10	Homo sapiens	76-82
21909411-3	2011	A high fat/methionine-choline deficient (MCD) diet, administered for 4 weeks, was used to induce NASH in rats.We demonstrated that CPT-I activity decreased, to the same extent, both in isolated liver mitochondria and in digitonin-permeabilized hepatocytes from MCD-diet fed rats.At the same time, the rate of total fatty acid oxidation to CO(2) and ketone bodies, measured in isolated hepatocytes, was significantly lowered in treated animals when compared to controls.	co(2)	339-344	carnitine palmitoyltransferase 1B	Rattus norvegicus	131-136
21522530-1	2010	In polymeric title compound, {[Co(2)(C(7)H(2)N(2)O(7))(2)(H(2)O)(6)] 2H(2)O}(n), obtained from the reaction of 3,5-dinitro-salicylic acid with cobalt(II) acetate, both Co(II) atoms are located on inversion centres and exhibit a distorted octahedral coordination geometry.	co(2)	31-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
21082809-2	2010	d-(-)-quinic acid is a cellular alpha-hydroxycarboxylate metal ion binder, which reacts with Co(II) and Zn(II) under pH-specific hydrothermal conditions, leading to the isolation of two new species [Co(2)(C(7)H(11)O(6))(4)](n) nH(2)O (1) and [Zn(3)(C(7)H(11)O(6))(6)](n) nH(2)O (2).	co(2)	199-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-99
21169508-4	2010	gtl1 plants had higher instantaneous WUE that was attributable to ~25% lower transpiration and stomatal conductance but equivalent CO(2) assimilation.	co(2)	131-136	GT-2-like 1	Arabidopsis thaliana	0-4
21124840-10	2010	The CA IV(-/-) sperm also have a reduced response to CO(2).	co(2)	53-58	carbonic anhydrase 4	Mus musculus	4-9
20839375-2	2010	Diverse reactions are discussed, such as the NHC-mediated addition of silyl pronucleophiles to a variety of electrophiles, NHC-promoted organic and inorganic polymerisation and the reduction of CO(2) by hydrosilanes as facilitated by NHCs.	co(2)	194-199	high mobility group nucleosomal binding domain 4	Homo sapiens	45-48
21589279-1	2010	In the title compound, [Co(2)(C(7)H(8)NO)(3)(N(3))(3)] CH(3)CN, the two Co(II) ions in the dinuclear complex have different coordination environments, both in a distorted octa-hedral geometry.	co(2)	24-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-78
20933433-1	2010	In maize, carbonic anhydrase (CA; EC 4.2.1.1) catalyzes the first reaction of the C(4) photosynthetic pathway; it catalyzes the hydration of CO(2) to bicarbonate and provides an inorganic carbon source for the primary carboxylation reaction catalyzed by phosphoenolpyruvate (PEP) carboxylase.	co(2)	141-146	carbonic anhydrase	Zea mays	10-28
20933433-1	2010	In maize, carbonic anhydrase (CA; EC 4.2.1.1) catalyzes the first reaction of the C(4) photosynthetic pathway; it catalyzes the hydration of CO(2) to bicarbonate and provides an inorganic carbon source for the primary carboxylation reaction catalyzed by phosphoenolpyruvate (PEP) carboxylase.	co(2)	141-146	carbonic anhydrase	Zea mays	30-32
20839375-2	2010	Diverse reactions are discussed, such as the NHC-mediated addition of silyl pronucleophiles to a variety of electrophiles, NHC-promoted organic and inorganic polymerisation and the reduction of CO(2) by hydrosilanes as facilitated by NHCs.	co(2)	194-199	high mobility group nucleosomal binding domain 4	Homo sapiens	123-126
20739606-10	2010	On the basis of the magnitude of the transient change in surface pH (DeltapH(S)) that were recorded as the oocytes were exposed to either CO(2) or NH(3), we conclude that zebrafish Aqp1a is permeable to both CO(2) and NH(3).	co(2)	138-143	aquaporin 1a (Colton blood group), tandem duplicate 1	Danio rerio	181-186
20739606-10	2010	On the basis of the magnitude of the transient change in surface pH (DeltapH(S)) that were recorded as the oocytes were exposed to either CO(2) or NH(3), we conclude that zebrafish Aqp1a is permeable to both CO(2) and NH(3).	co(2)	208-213	aquaporin 1a (Colton blood group), tandem duplicate 1	Danio rerio	181-186
20739606-12	2010	Thus, compared with human AQP1, zebrafish Aqp1a has about twice the selectivity for CO(2) over NH(3).	co(2)	84-89	aquaporin 1a (Colton blood group), tandem duplicate 1	Danio rerio	42-47
20307691-2	2010	Here, we review evidence from mouse and human genetics that argue for the crucial role in CO(2) chemosensitivity of a limited set of central neurons that express the Phox2b transcription factor and are disabled by Phox2b mutations.	co(2)	90-95	paired like homeobox 2B	Homo sapiens	166-172
20923141-5	2010	In NO(x) + O(2), NO(2) directly interacts with the free carbon sites (C C*) through two parallel reactions: (1) NO(2) + C C*   C C O + NO; (2) NO(2) + C C*   NCO(-) + CO(2).	co(2)	167-172	ryanodine receptor 1	Homo sapiens	127-132
20876337-7	2010	Loss of mMDH also affects photorespiration, as evidenced by a lower postillumination burst, alterations in CO(2) assimilation/intercellular CO(2) curves at low CO(2), and the light-dependent elevated concentration of photorespiratory metabolites.	co(2)	107-112	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	8-12
20876337-7	2010	Loss of mMDH also affects photorespiration, as evidenced by a lower postillumination burst, alterations in CO(2) assimilation/intercellular CO(2) curves at low CO(2), and the light-dependent elevated concentration of photorespiratory metabolites.	co(2)	140-145	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	8-12
20876337-7	2010	Loss of mMDH also affects photorespiration, as evidenced by a lower postillumination burst, alterations in CO(2) assimilation/intercellular CO(2) curves at low CO(2), and the light-dependent elevated concentration of photorespiratory metabolites.	co(2)	140-145	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	8-12
20724559-4	2010	The CO(2) reserve was defined as the minimal change in end-tidal PCO(2) (PET(CO(2))) between eupnea and hypocapnic central apnea.	co(2)	4-9	complement C2	Homo sapiens	73-83
20813909-5	2010	Compared with the wild type, net photosynthetic CO(2) fixation in fib4 KD trees was decreased at high light intensity but was increased at low light intensity.	co(2)	48-53	Plastid-lipid associated protein PAP / fibrillin family protein	Arabidopsis thaliana	66-70
20307691-2	2010	Here, we review evidence from mouse and human genetics that argue for the crucial role in CO(2) chemosensitivity of a limited set of central neurons that express the Phox2b transcription factor and are disabled by Phox2b mutations.	co(2)	90-95	paired like homeobox 2B	Homo sapiens	214-220
20307691-3	2010	A common trait of different Phox2b mutations that impair CO(2) responsiveness in the embryo and respiration in neonates is the depletion of Phox2b-expressing neurons in the retrotrapezoid nucleus, providing genetic evidence for their importance for proper breathing and central chemosensitivity at birth.	co(2)	57-62	paired like homeobox 2B	Homo sapiens	28-34
20307691-3	2010	A common trait of different Phox2b mutations that impair CO(2) responsiveness in the embryo and respiration in neonates is the depletion of Phox2b-expressing neurons in the retrotrapezoid nucleus, providing genetic evidence for their importance for proper breathing and central chemosensitivity at birth.	co(2)	57-62	paired like homeobox 2B	Homo sapiens	140-146
20736419-5	2010	Cx26 in isolated patches responded to changes in PCO2, suggesting direct CO(2) sensitivity of the hemichannel to CO(2).	co(2)	73-78	gap junction protein beta 2	Homo sapiens	0-4
20736419-5	2010	Cx26 in isolated patches responded to changes in PCO2, suggesting direct CO(2) sensitivity of the hemichannel to CO(2).	co(2)	113-118	gap junction protein beta 2	Homo sapiens	0-4
20736419-6	2010	Heterologous expression of Cx26 in HeLa cells was sufficient to endow them with the capacity to release ATP in a CO(2)-sensitive manner.	co(2)	113-118	gap junction protein beta 2	Homo sapiens	27-31
20736419-9	2010	The more distant Cx43 exhibited CO(2)-dependent closing (possibly mediated through intracellular acidification), while Cx36 displayed no CO(2) sensitivity.	co(2)	32-37	gap junction protein alpha 1	Homo sapiens	17-21
20736419-10	2010	These surprising findings suggest that connexins may play a hitherto unappreciated variety of signalling roles, and that Cx26 and related beta connexins may impart direct sensitivity to CO(2) throughout the brain.	co(2)	186-191	gap junction protein beta 2	Homo sapiens	121-125
20736421-6	2010	As agents that act on connexin channels block this release, but compounds selective for pannexin-1 have no effect, we conclude that a connexin hemichannel is involved in CO(2)-dependent ATP release.	co(2)	170-175	pannexin 1	Homo sapiens	88-98
20812721-4	2010	The GREEN-MAC-LCCP model assesses the direct and indirect CO(2) equivalent emissions related to MACs usage, as well as those associated with the production, use and disposal of alternative refrigerants and MACs components.	co(2)	58-63	angiomotin like 2	Homo sapiens	14-18
20736421-9	2010	This distribution of CO(2)-dependent dye loading closely mirrors that of Cx26 expression and colocalizes to glial fibrillary acidic protein (GFAP)-positive cells.	co(2)	21-26	gap junction protein beta 2	Homo sapiens	73-77
20736421-9	2010	This distribution of CO(2)-dependent dye loading closely mirrors that of Cx26 expression and colocalizes to glial fibrillary acidic protein (GFAP)-positive cells.	co(2)	21-26	glial fibrillary acidic protein	Homo sapiens	108-139
20736421-9	2010	This distribution of CO(2)-dependent dye loading closely mirrors that of Cx26 expression and colocalizes to glial fibrillary acidic protein (GFAP)-positive cells.	co(2)	21-26	glial fibrillary acidic protein	Homo sapiens	141-145
20657033-7	2010	With regard to CO(2)-triggered intracellular acidification, a cooperative effect was observed, where maximum rates were measured when the tetramer consisted of NtAQP1 aquaporins only.	co(2)	15-20	probable aquaporin TIP1-1	Nicotiana tabacum	160-166
20657033-8	2010	The results confirm the model of an aquaporin monomer as a functional unit for water transport and suggest that, for CO(2)-related transport processes, a structure built up by the tetramer is the basis of this function.	co(2)	117-122	aquaporin PIP2-7-like	Nicotiana tabacum	36-45
20817876-4	2010	In this study, we demonstrate that mammalian cells (mouse embryonic fibroblasts and others) also sense changes in local CO(2) levels, leading to altered gene expression via the NF-kappaB pathway.	co(2)	120-125	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	177-186
20649907-5	2010	The results showed that a single epsilonproteobacterium, affiliated with the genus Sulfurimonas, and two different members of the gammaproteobacterial sulfur oxidizer (GSO) cluster were responsible for dark CO(2) fixation activities in the upper sulfidic layer of the Black Sea redoxcline.	co(2)	207-212	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	274-277
20817876-5	2010	IKKalpha, a central regulatory component of NF-kappaB, rapidly and reversibly translocates to the nucleus in response to elevated CO(2).	co(2)	130-135	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	0-8
20817876-5	2010	IKKalpha, a central regulatory component of NF-kappaB, rapidly and reversibly translocates to the nucleus in response to elevated CO(2).	co(2)	130-135	nuclear factor kappa B subunit 1	Homo sapiens	44-53
20881114-4	2010	Here we show that CO(2) specifically activates a subpopulation of trigeminal neurons that express TRPA1, a mustard oil- and cinnamaldehyde-sensitive channel, and that these responses are dependent on a functional TRPA1 gene.	co(2)	18-23	transient receptor potential cation channel subfamily A member 1	Homo sapiens	98-103
20978221-3	2010	The sco3-1 mutation alters chloroplast morphology and development, reduces chlorophyll accumulation, impairs thylakoid formation and photosynthesis in seedlings, and results in photoinhibition under extreme CO(2) concentrations in mature leaves.	co(2)	207-212	SNOWY COTYLEDON protein (DUF566)	Arabidopsis thaliana	4-8
20403465-4	2010	An enzyme involved in synephrine biosynthesis, tyrosine decarboxylase (TYDC), is a pyridoxal-5"-phosphate (PLP)-dependent enzyme that decarboxylates tyrosine to yield CO(2) and tyramine.	co(2)	167-172	pyridoxal phosphatase	Homo sapiens	107-110
20881114-4	2010	Here we show that CO(2) specifically activates a subpopulation of trigeminal neurons that express TRPA1, a mustard oil- and cinnamaldehyde-sensitive channel, and that these responses are dependent on a functional TRPA1 gene.	co(2)	18-23	transient receptor potential cation channel subfamily A member 1	Homo sapiens	213-218
20881114-5	2010	TRPA1 is sufficient to mediate responses to CO(2) as TRPA1 channels expressed in HEK-293 cells, but not TRPV1 channels, were activated by bath-applied CO(2).	co(2)	44-49	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
20881114-5	2010	TRPA1 is sufficient to mediate responses to CO(2) as TRPA1 channels expressed in HEK-293 cells, but not TRPV1 channels, were activated by bath-applied CO(2).	co(2)	44-49	transient receptor potential cation channel subfamily A member 1	Homo sapiens	53-58
20881114-5	2010	TRPA1 is sufficient to mediate responses to CO(2) as TRPA1 channels expressed in HEK-293 cells, but not TRPV1 channels, were activated by bath-applied CO(2).	co(2)	151-156	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
20881114-5	2010	TRPA1 is sufficient to mediate responses to CO(2) as TRPA1 channels expressed in HEK-293 cells, but not TRPV1 channels, were activated by bath-applied CO(2).	co(2)	151-156	transient receptor potential cation channel subfamily A member 1	Homo sapiens	53-58
20881114-6	2010	CO(2) can diffuse into cells and produce intracellular acidification, which could gate TRPA1 channels.	co(2)	0-5	transient receptor potential cation channel subfamily A member 1	Homo sapiens	87-92
20881114-8	2010	We conclude that TRPA1, by sensing intracellular acidification, constitutes an important component of the nociceptive response to CO(2).	co(2)	130-135	transient receptor potential cation channel subfamily A member 1	Homo sapiens	17-22
20805497-5	2010	We found that Lmx1b(f/f/p) mice completely lacked any arousal response to inhalation of 10% CO(2) (with 21% O(2) in balance N(2)) but had normal arousal responses to hypoxia, sound, and air puff.	co(2)	92-97	LIM homeobox transcription factor 1 beta	Mus musculus	14-19
20844141-5	2010	In the absence or presence of the peripheral chemoreceptor input, inhibiting the Phox2b-expressing neurons during hypercapnia abolished the CO(2)-evoked abdominal expiratory activity in anesthetized rats and in situ preparations.	co(2)	140-145	paired-like homeobox 2b	Rattus norvegicus	81-87
20844141-7	2010	These data indicate a crucial dependence of central expiratory drive upon Phox2b-expressing neurons of the ventrolateral brainstem and support the hypothesis that these neurons contribute in a significant manner to CO(2)-evoked increases of inspiratory activity.	co(2)	215-220	paired-like homeobox 2b	Rattus norvegicus	74-80
21587377-1	2010	In the polymeric title compound, [Co(2)(C(3)H(7)NO)(3)(C(8)H(3)NO(6))(2)] C(3)H(7)NO, one 5-nitro-isophthalate dianion has its two carboxyl-ate groups chelating to one Co(II) atom while simultaneously coordinating to another metal atom in a mu(4)-bridging mode.	co(2)	34-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	168-174
20616155-9	2010	The deficiency of NTRC caused a more severe phenotype than the deficiency of Trx chi or 2-Cys Prxs as determined by growth, pigment content, CO(2) fixation, and F(v)/F(m), indicating additional functions of NTRC.	co(2)	141-146	NADPH-dependent thioredoxin reductase C	Arabidopsis thaliana	18-22
20802117-8	2010	Exposure to hypercapnia (1% CO(2) in air) resulted in downregulated gill and erythrocyte Rhag mRNA.	co(2)	28-33	ammonium transporter Rh type A	Takifugu rubripes	89-93
20578724-1	2010	The catalysis of CO(2) hydration by human carbonic anhydrase II (HCA II) is limited in maximal velocity by proton transfer from a zinc-bound water molecule to the proton shuttle His64.	co(2)	17-22	carbonic anhydrase 2	Homo sapiens	42-63
20715287-0	2010	In situ infrared study of the role of PEG in stabilizing silica-supported amines for CO(2) capture.	co(2)	85-90	progestagen associated endometrial protein	Homo sapiens	38-41
20715287-2	2010	The CO(2) capture capacities of TEPA/SiO(2) and PEG/TEPA/SiO(2) are determined to be 2087 and 1110 micromol CO(2) g(-1) sorbent, respectively.	co(2)	4-9	progestagen associated endometrial protein	Homo sapiens	48-51
20715287-2	2010	The CO(2) capture capacities of TEPA/SiO(2) and PEG/TEPA/SiO(2) are determined to be 2087 and 1110 micromol CO(2) g(-1) sorbent, respectively.	co(2)	108-113	progestagen associated endometrial protein	Homo sapiens	48-51
20620242-5	2010	It is suggested that CO(2) does not affect TH expression in the CB, and that it inhibits hypoxia-enhanced TH expression.	co(2)	21-26	tyrosine hydroxylase	Rattus norvegicus	106-108
20303745-4	2010	The activated carbon prepared using CO(2) activation has the largest BET surface area, however the activation time is approximately 2.5 times higher than the activation using steam or mixture of steam-CO(2).	co(2)	36-41	delta/notch like EGF repeat containing	Homo sapiens	69-72
20484701-2	2010	Insulin and IGF-I significantly reduced the production of CO(2) from oleic acid with respect to the control values.	co(2)	58-63	insulin-like growth factor I	Oncorhynchus mykiss	12-17
20484701-7	2010	Rosiglitazone (a peroxisome proliferator-activated receptor gamma agonist) and etomoxir (a CPT-1 inhibitor) produced a severe and significant reduction in the production of CO(2) and ASP.	co(2)	173-178	peroxisome proliferator-activated receptor gamma	Oncorhynchus mykiss	17-65
20484701-7	2010	Rosiglitazone (a peroxisome proliferator-activated receptor gamma agonist) and etomoxir (a CPT-1 inhibitor) produced a severe and significant reduction in the production of CO(2) and ASP.	co(2)	173-178	carnitine palmitoyl transferase I	Oncorhynchus mykiss	91-96
20624682-2	2010	This change led to a steady increase of 16% of the catalytic activity of the mutant hCA I over the wild type enzyme, which is a gain of 50% catalytic efficiency if one compares hCA I and hCA II as catalysts for CO(2) hydration.	co(2)	211-216	carbonic anhydrase 1	Homo sapiens	84-89
20624682-2	2010	This change led to a steady increase of 16% of the catalytic activity of the mutant hCA I over the wild type enzyme, which is a gain of 50% catalytic efficiency if one compares hCA I and hCA II as catalysts for CO(2) hydration.	co(2)	211-216	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	177-193
20547681-2	2010	Hypothalamic orexin neurons are CO(2) sensitive in vitro, prepro-orexin knockout mice have a reduced CO(2) response prominently in wakefulness, and focal antagonism of the orexin receptor 1 (OX(1)R) in two central chemoreceptor sites, the retrotrapezoid nucleus (RTN) or the medullary raphe, results in a reduction of the CO(2) response predominately in wakefulness (-30% and -16%, respectively).	co(2)	32-37	hypocretin	Mus musculus	13-19
20547681-2	2010	Hypothalamic orexin neurons are CO(2) sensitive in vitro, prepro-orexin knockout mice have a reduced CO(2) response prominently in wakefulness, and focal antagonism of the orexin receptor 1 (OX(1)R) in two central chemoreceptor sites, the retrotrapezoid nucleus (RTN) or the medullary raphe, results in a reduction of the CO(2) response predominately in wakefulness (-30% and -16%, respectively).	co(2)	32-37	hypocretin (orexin) receptor 1	Mus musculus	191-197
20547681-2	2010	Hypothalamic orexin neurons are CO(2) sensitive in vitro, prepro-orexin knockout mice have a reduced CO(2) response prominently in wakefulness, and focal antagonism of the orexin receptor 1 (OX(1)R) in two central chemoreceptor sites, the retrotrapezoid nucleus (RTN) or the medullary raphe, results in a reduction of the CO(2) response predominately in wakefulness (-30% and -16%, respectively).	co(2)	101-106	hypocretin	Mus musculus	58-71
20547681-2	2010	Hypothalamic orexin neurons are CO(2) sensitive in vitro, prepro-orexin knockout mice have a reduced CO(2) response prominently in wakefulness, and focal antagonism of the orexin receptor 1 (OX(1)R) in two central chemoreceptor sites, the retrotrapezoid nucleus (RTN) or the medullary raphe, results in a reduction of the CO(2) response predominately in wakefulness (-30% and -16%, respectively).	co(2)	101-106	hypocretin	Mus musculus	58-71
20547681-3	2010	Here we hypothesize that acute and selective inhibition of both orexin receptors (OX(1)R and OX(2)R) at all central locations by an orally administered dual orexin receptor antagonist, almorexant, will substantially attenuate the CO(2) response in a vigilance-state- and diurnal-cycle-dependent manner.	co(2)	230-235	hypocretin	Mus musculus	64-70
20547681-3	2010	Here we hypothesize that acute and selective inhibition of both orexin receptors (OX(1)R and OX(2)R) at all central locations by an orally administered dual orexin receptor antagonist, almorexant, will substantially attenuate the CO(2) response in a vigilance-state- and diurnal-cycle-dependent manner.	co(2)	230-235	hypocretin receptor 1	Rattus norvegicus	82-88
20547681-3	2010	Here we hypothesize that acute and selective inhibition of both orexin receptors (OX(1)R and OX(2)R) at all central locations by an orally administered dual orexin receptor antagonist, almorexant, will substantially attenuate the CO(2) response in a vigilance-state- and diurnal-cycle-dependent manner.	co(2)	230-235	hypocretin receptor 2	Rattus norvegicus	93-99
20610767-3	2010	Here, we show that isoflurane causes robust activation of CO(2)/pH-sensitive, Phox2b-expressing neurons located in the retrotrapezoid nucleus (RTN) of the rodent brainstem, in vitro and in vivo.	co(2)	58-63	paired-like homeobox 2b	Rattus norvegicus	78-84
21152274-1	2010	Complexes (H(2)O/CO(2), e-(H(2)O/CO(2)) and h(+)-(H(2)O/CO(2))) in the reaction system of CO(2) photoreduction with H(2)O were researched by B3LYP and MP2 methods along with natural bond orbital (NBO) analysis.	co(2)	17-22	tryptase pseudogene 1	Homo sapiens	151-154
21152274-1	2010	Complexes (H(2)O/CO(2), e-(H(2)O/CO(2)) and h(+)-(H(2)O/CO(2))) in the reaction system of CO(2) photoreduction with H(2)O were researched by B3LYP and MP2 methods along with natural bond orbital (NBO) analysis.	co(2)	33-38	tryptase pseudogene 1	Homo sapiens	151-154
21152274-1	2010	Complexes (H(2)O/CO(2), e-(H(2)O/CO(2)) and h(+)-(H(2)O/CO(2))) in the reaction system of CO(2) photoreduction with H(2)O were researched by B3LYP and MP2 methods along with natural bond orbital (NBO) analysis.	co(2)	33-38	tryptase pseudogene 1	Homo sapiens	151-154
20513717-5	2010	In addition, increasing atmospheric CO(2) is predicted to alter molar CNP ratios of detrital inputs, which could lead to profound shifts in the stoichiometry of elemental fluxes between consumers and resources at the base of the food web.	co(2)	36-41	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	70-73
20472102-2	2010	The protein abundance and activity of CAII in erythrocytes was significantly higher in CO(2)-exposed embryos compared to normal conditions.	co(2)	87-92	carbonic anhydrase 2	Gallus gallus	38-42
20472102-7	2010	This study shows for the first time that chicken embryos adapt to CO(2) during the second half of incubation by increasing CAII protein expression and function in red blood cells.	co(2)	66-71	carbonic anhydrase 2	Gallus gallus	123-127
20445914-6	2010	These were combined with the kinetic data to estimate 100-year time horizon global warming potentials relative to CO(2) of 69, 337, 499 and 36 for HFE-7200, HFE-7100, HFE-7000 and CF(3)CF(2)CF(2)CH(2)OH, respectively.	co(2)	114-119	homeostatic iron regulator	Homo sapiens	147-150
20498861-1	2010	A Zn-MOF assembled from a new C(2h)-symmetric terphenyl dicarboxylate and DABCO was prepared and characterized by X-ray crystallography and gas sorption analysis: a preferential sorption of CO(2) over N(2) and H(2) was observed with an exceptionally high CO(2) adsorption enthalpy.	co(2)	190-195	lysine acetyltransferase 8	Homo sapiens	5-8
20498861-1	2010	A Zn-MOF assembled from a new C(2h)-symmetric terphenyl dicarboxylate and DABCO was prepared and characterized by X-ray crystallography and gas sorption analysis: a preferential sorption of CO(2) over N(2) and H(2) was observed with an exceptionally high CO(2) adsorption enthalpy.	co(2)	255-260	lysine acetyltransferase 8	Homo sapiens	5-8
19909401-9	2010	CONCLUSION: The CO(2) laser treatment in coagulation mode produced the expression of heat shock proteins, and the findings suggest that while Hsp70 mainly conferred cell protection, Hsp25 was involved in the progress of wound repair as well as cell protection.	co(2)	16-21	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	142-147
19909401-9	2010	CONCLUSION: The CO(2) laser treatment in coagulation mode produced the expression of heat shock proteins, and the findings suggest that while Hsp70 mainly conferred cell protection, Hsp25 was involved in the progress of wound repair as well as cell protection.	co(2)	16-21	heat shock protein family B (small) member 1	Rattus norvegicus	182-187
20466559-3	2010	Since the effects are revealed at (sub)micromolar concentrations of HCO(3)(-), the specific high-affinity binding of HCO(3)(-) (or CO(2)) to MSP (required for its native structure preservation) is proposed.	co(2)	131-136	microseminoprotein beta	Homo sapiens	141-144
20482580-1	2010	Nitrogen (N) effects on ecosystem carbon (C) budgets are critical to understand as C sequestration is considered as a mechanism to offset anthropogenic CO(2) emissions.	co(2)	152-157	steroid sulfatase	Homo sapiens	80-84
20181427-7	2010	Based on the short-term decrease of benzene concentration and the long-term increase of CO(2) concentration, the photocatalytic ability of the HM140 sample is significantly superior to that of P25.	co(2)	88-93	tubulin polymerization promoting protein	Homo sapiens	193-196
20188818-6	2010	In addition, cultured isolated neutrophils (37 degrees C and 5% CO(2)) also released Hsp72 under basal conditions, with this release increasing from 10min to 24h in the absence of cell damage.	co(2)	64-69	heat shock protein family A (Hsp70) member 1A	Homo sapiens	85-90
20426470-1	2010	We constructed a cultivation system with a controlled light period, light intensity, temperature, and CO(2) concentration for mass production of the taste-modifying protein miraculin from transgenic tomatoes.	co(2)	102-107	miraculin	Solanum lycopersicum	173-182
20228277-5	2010	CO(2) laser irradiation to the gingiva just after tooth movement caused a significant decrease of Fos-IR neurons.	co(2)	0-5	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	98-101
20172967-10	2010	Metabolically the Ebf1(-/-) mice had increased O(2) consumption, CO(2) production, food and water intake, and activity.	co(2)	65-70	early B cell factor 1	Mus musculus	18-22
20408975-3	2010	When the chilling stress was preceded by CO(2) laser irradiation, the concentrations of malondialdehyde and oxidized glutathione were decreased while the activities of nitric oxide synthase, catalase, peroxidase, superoxide dismutase and the concentrations of nitric oxide and glutathione increased.	co(2)	41-46	catalase-1	Triticum aestivum	191-199
20390007-3	2010	An unambiguous determination of the target, TNT, in soil samples collected from an explosives test site in China Lake Naval Air Weapons Station is achieved through the use of a tunable CO(2) laser that scans over the absorption fingerprint of the target explosives.	co(2)	185-190	chromosome 16 open reading frame 82	Homo sapiens	44-47
20075262-5	2010	CNS P(CO(2)) also influences sympathetic tone in a CRG-independent manner, and we propose that this process operates differently according to the level of CNS P(CO(2)).	co(2)	6-11	chromodomain helicase DNA binding protein 7	Homo sapiens	51-54
20171120-7	2010	Unique ions from internal losses of the glycerol residues were seen in the MS(3) spectra of [M + Alk - R(n)CO(2)H](+) (n = 1, 2, 3) and of [M + Alk - R(n)CO(2)Alk](+) (Alk = Li, Na, NH(4); n = 1, 3).	co(2)	107-112	ALK receptor tyrosine kinase	Homo sapiens	97-100
20118663-4	2010	The CO(2) concentrating mechanism in C4 and CAM plants is expected to contribute to decreasing ROS generation.	co(2)	4-9	calmodulin 3	Homo sapiens	44-47
20450730-14	2010	The CO(2) environment up-regulates the level of IL-6.	co(2)	4-9	interleukin 6	Homo sapiens	48-52
20034963-5	2010	Exposure of AEC to 80% oxygen/5% CO(2) for 48 h did not induce overt toxicity, but resulted in significantly decreased GM-CSF protein and mRNA expression compared with cells in normoxia.	co(2)	33-38	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	119-125
19969349-1	2010	In this study the effect of high pressure CO(2) on the synthesis and characteristics of elastin-based hybrid hydrogels was investigated.	co(2)	42-47	elastin	Homo sapiens	88-95
19969349-2	2010	Tropoelastin/alpha-elastin hybrid hydrogels were fabricated by chemically cross-linking tropoelastin/alpha-elastin solutions with glutaraldehyde at high pressure CO(2).	co(2)	162-167	elastin	Homo sapiens	0-12