PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27132804-3	2016	Combined treatment with Q+C was much more effective than either Q or C in inhibiting DNMT, causing global hypomethylation, restoring AR mRNA and protein levels and causing apoptosis via mitochondrial depolarization of PC3 and DU145.	q+c	24-27	DNA methyltransferase 1	Homo sapiens	85-89
27132804-3	2016	Combined treatment with Q+C was much more effective than either Q or C in inhibiting DNMT, causing global hypomethylation, restoring AR mRNA and protein levels and causing apoptosis via mitochondrial depolarization of PC3 and DU145.	q+c	24-27	androgen receptor	Homo sapiens	133-135
27132804-3	2016	Combined treatment with Q+C was much more effective than either Q or C in inhibiting DNMT, causing global hypomethylation, restoring AR mRNA and protein levels and causing apoptosis via mitochondrial depolarization of PC3 and DU145.	q+c	24-27	chromobox 8	Homo sapiens	218-221
27132804-5	2016	Bisulfite sequencing revealed high methylation of AR promoter CpG sites in AR-negative DU145 and PC3 cell lines that was significantly demethylated by Q+C treatment, which restored AR expression.	q+c	151-154	androgen receptor	Homo sapiens	50-52
27132804-5	2016	Bisulfite sequencing revealed high methylation of AR promoter CpG sites in AR-negative DU145 and PC3 cell lines that was significantly demethylated by Q+C treatment, which restored AR expression.	q+c	151-154	androgen receptor	Homo sapiens	75-77
27132804-5	2016	Bisulfite sequencing revealed high methylation of AR promoter CpG sites in AR-negative DU145 and PC3 cell lines that was significantly demethylated by Q+C treatment, which restored AR expression.	q+c	151-154	chromobox 8	Homo sapiens	97-100
27132804-5	2016	Bisulfite sequencing revealed high methylation of AR promoter CpG sites in AR-negative DU145 and PC3 cell lines that was significantly demethylated by Q+C treatment, which restored AR expression.	q+c	151-154	androgen receptor	Homo sapiens	75-77
27132804-6	2016	Notable synergistic effects of Q+C combination in re-sensitizing androgen refractory CaP cells to AR-mediated apoptosis, their known safety in clinical use, and epidemiological evidences relating their dietary consumption with lower cancer incidences indicate their potential for use in chemoprevention of androgen resistance in prostate cancer.	q+c	31-34	androgen receptor	Homo sapiens	98-100