PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 27132804-3 2016 Combined treatment with Q+C was much more effective than either Q or C in inhibiting DNMT, causing global hypomethylation, restoring AR mRNA and protein levels and causing apoptosis via mitochondrial depolarization of PC3 and DU145. q+c 24-27 DNA methyltransferase 1 Homo sapiens 85-89 27132804-3 2016 Combined treatment with Q+C was much more effective than either Q or C in inhibiting DNMT, causing global hypomethylation, restoring AR mRNA and protein levels and causing apoptosis via mitochondrial depolarization of PC3 and DU145. q+c 24-27 androgen receptor Homo sapiens 133-135 27132804-3 2016 Combined treatment with Q+C was much more effective than either Q or C in inhibiting DNMT, causing global hypomethylation, restoring AR mRNA and protein levels and causing apoptosis via mitochondrial depolarization of PC3 and DU145. q+c 24-27 chromobox 8 Homo sapiens 218-221 27132804-5 2016 Bisulfite sequencing revealed high methylation of AR promoter CpG sites in AR-negative DU145 and PC3 cell lines that was significantly demethylated by Q+C treatment, which restored AR expression. q+c 151-154 androgen receptor Homo sapiens 50-52 27132804-5 2016 Bisulfite sequencing revealed high methylation of AR promoter CpG sites in AR-negative DU145 and PC3 cell lines that was significantly demethylated by Q+C treatment, which restored AR expression. q+c 151-154 androgen receptor Homo sapiens 75-77 27132804-5 2016 Bisulfite sequencing revealed high methylation of AR promoter CpG sites in AR-negative DU145 and PC3 cell lines that was significantly demethylated by Q+C treatment, which restored AR expression. q+c 151-154 chromobox 8 Homo sapiens 97-100 27132804-5 2016 Bisulfite sequencing revealed high methylation of AR promoter CpG sites in AR-negative DU145 and PC3 cell lines that was significantly demethylated by Q+C treatment, which restored AR expression. q+c 151-154 androgen receptor Homo sapiens 75-77 27132804-6 2016 Notable synergistic effects of Q+C combination in re-sensitizing androgen refractory CaP cells to AR-mediated apoptosis, their known safety in clinical use, and epidemiological evidences relating their dietary consumption with lower cancer incidences indicate their potential for use in chemoprevention of androgen resistance in prostate cancer. q+c 31-34 androgen receptor Homo sapiens 98-100