PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11101640-4	2000	In order to validate the technique, the kinetics of monocarboxylate transport were measured in oocytes expressing MCT1.	monocarboxylate	52-67	solute carrier family 16 member 1	Homo sapiens	114-118
11785685-10	2001	CONCLUSION: L-Lactic acid transport at the iBRB is an H-coupled and carrier-mediated mechanism via MCT1 that is competitively inhibited by monocarboxylate drugs.	monocarboxylate	139-154	solute carrier family 16 member 1	Rattus norvegicus	99-103
11248400-9	2001	Furthermore, their brains react to a diet that increases monocarboxylate levels in the blood by enhancing their capability to take up both monocarboxylates (MCT1 upregulation) and glucose (GLUT1 upregulation).	monocarboxylate	57-72	solute carrier family 16 member 1	Rattus norvegicus	157-161
11248400-9	2001	Furthermore, their brains react to a diet that increases monocarboxylate levels in the blood by enhancing their capability to take up both monocarboxylates (MCT1 upregulation) and glucose (GLUT1 upregulation).	monocarboxylate	57-72	solute carrier family 2 member 1	Rattus norvegicus	189-194
3060326-10	1988	Thus, monocarboxylate transport, at least in the nominal absence of HCO3-, can have a major impact on pHi regulation.	monocarboxylate	6-21	glucose-6-phosphate isomerase	Homo sapiens	102-105
10417314-3	1999	Monocarboxylate transport via MCT2 was driven by the H(+) gradient over the plasma membrane.	monocarboxylate	0-15	solute carrier family 16 member 7	Rattus norvegicus	30-34
10419965-11	1999	Thus, these data provide strong evidence that sorbate and benzoate anions compete with fluorescein for a putative monocarboxylate binding site on the Pdr12 transporter.	monocarboxylate	114-129	ATP-binding cassette multidrug transporter PDR12	Saccharomyces cerevisiae S288C	150-155
34631536-2	2021	SLC16A1, as a key factor in catalysis of monocarboxylate transport across the plasma membrane, has been found to be associated with the occurrence and metastasis of a variety of cancers, but its prognostic significance and mechanism in different tumors are still unclear.	monocarboxylate	41-56	solute carrier family 16 member 1	Homo sapiens	0-7
10926847-6	2000	Similar to other members of this family, monocarboxylate transport via MCT4 is accompanied by the transport of H(+) across the plasma membrane.	monocarboxylate	41-56	solute carrier family 16 member 3	Rattus norvegicus	71-75
10926847-13	2000	Monocarboxylate transport via MCT4 could be competitively inhibited by alpha-cyano-4-hydroxycinnamate, phloretin and partly by 4, 4"-di-isothiocyanostilbene-2,2"-disulphonic acid.	monocarboxylate	0-15	solute carrier family 16 member 3	Rattus norvegicus	30-34
10926847-14	2000	Similar to MCT1, monocarboxylate transport via MCT4 was sensitive to inhibition by the thiol reagent p-chloromercuribenzoesulphonic acid.	monocarboxylate	17-32	solute carrier family 16 member 1	Rattus norvegicus	11-15
10926847-14	2000	Similar to MCT1, monocarboxylate transport via MCT4 was sensitive to inhibition by the thiol reagent p-chloromercuribenzoesulphonic acid.	monocarboxylate	17-32	solute carrier family 16 member 3	Rattus norvegicus	47-51
10519059-11	1999	These data suggest that Fos stimulus-transcription cascade is activated in these cells by decreased central availability of this monocarboxylate fuel, and that cellular sources of regulatory signaling of lactate utilization exist within the periventricular CNS.	monocarboxylate	129-144	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	24-27
9632638-6	1998	The kinetics and substrate and inhibitor specificities of monocarboxylate transport into cell lines expressing only MCT3 or MCT1 have been determined.	monocarboxylate	58-73	solute carrier family 16 member 3	Rattus norvegicus	116-120
9632638-6	1998	The kinetics and substrate and inhibitor specificities of monocarboxylate transport into cell lines expressing only MCT3 or MCT1 have been determined.	monocarboxylate	58-73	solute carrier family 16 member 1	Rattus norvegicus	124-128
1660483-6	1991	These results suggest that L-lactate is translocated through CAD-inhibitable new pathways induced in the host cell membrane by parasite activity, probably by diffusion of the acid form and through a modified native monocarboxylate:H+ symporter.	monocarboxylate	215-230	aconitate decarboxylase 1	Homo sapiens	61-64
33557247-9	2021	Our findings provide evidence that PrPc might affect the monocarboxylate intercellular transport, which needs to be confirmed in further studies.	monocarboxylate	57-72	prion protein	Mus musculus	35-39
7241575-2	1981	Cleavage of 55% of the lecithin in intact human erythrocytes by phospholipase A2 (bee venom) markedly inhibits the mediated transport of L-lactate (via the monocarboxylate carrier) and of L-arabinose (via the monosaccharide carrier), while the major anion exchange system (probed by oxalate) and diffusion via the lipid domain (probed by erythritol) remain essentially unaltered.	monocarboxylate	156-171	phospholipase A2 group IB	Homo sapiens	64-80
33862459-5	2021	Olfr78 was abundantly expressed in the colon and mouse enteroendocrine cell line STC-1 and showed specific affinity to SCFAs such as acetate and propionate, but not butyrate, in a monocarboxylate ligand screening assay using a heterologous expression system.	monocarboxylate	180-195	olfactory receptor family 51 subfamily E member 2	Mus musculus	0-6
33862459-5	2021	Olfr78 was abundantly expressed in the colon and mouse enteroendocrine cell line STC-1 and showed specific affinity to SCFAs such as acetate and propionate, but not butyrate, in a monocarboxylate ligand screening assay using a heterologous expression system.	monocarboxylate	180-195	stanniocalcin 1	Mus musculus	81-86
32415067-2	2020	To discover how MCTs solve this fundamental aspect of intracellular monocarboxylate homeostasis in the context of multicellular organisms, we analyzed pyruvate transport activity of human monocarboxylate transporter 2 (MCT2).	monocarboxylate	68-83	solute carrier family 16 member 7	Homo sapiens	188-217
24485392-1	2015	OBJECTIVES: The A1470T polymorphism (rs1049434) in the monocarboxylate (lactate/pyruvate) transporter 1 gene (MCT1) has been suggested to influence athletic performance in the general population.	monocarboxylate	55-70	solute carrier family 16 member 1	Homo sapiens	110-114
32999202-8	2020	Moreover, we identified connexin 43 (Cx43) hemichannels as a new membrane transport system that is activated under pathological conditions and recognizes several monocarboxylate drugs, such as valproate.	monocarboxylate	162-177	gap junction protein alpha 1	Homo sapiens	24-35
32999202-8	2020	Moreover, we identified connexin 43 (Cx43) hemichannels as a new membrane transport system that is activated under pathological conditions and recognizes several monocarboxylate drugs, such as valproate.	monocarboxylate	162-177	gap junction protein alpha 1	Homo sapiens	37-41
31098988-1	2019	Sodium-coupled monocarboxylate transporter SMCT1 (SLC5A8) mediates monocarboxylate transport in the proximal tubule of the kidney.	monocarboxylate	15-30	solute carrier family 5 member 8	Homo sapiens	43-48
31098988-1	2019	Sodium-coupled monocarboxylate transporter SMCT1 (SLC5A8) mediates monocarboxylate transport in the proximal tubule of the kidney.	monocarboxylate	15-30	solute carrier family 5 member 8	Homo sapiens	50-56
28923861-3	2017	In this study, we assessed the impact of the MCT1 inhibitor AZD3965 on cancer cell metabolism in vitro and in vivo Exposing human lymphoma and colon carcinoma cells to AZD3965 increased MCT4-dependent accumulation of intracellular lactate, inhibiting monocarboxylate influx and efflux.	monocarboxylate	251-266	solute carrier family 16 member 1	Homo sapiens	45-49
28923861-3	2017	In this study, we assessed the impact of the MCT1 inhibitor AZD3965 on cancer cell metabolism in vitro and in vivo Exposing human lymphoma and colon carcinoma cells to AZD3965 increased MCT4-dependent accumulation of intracellular lactate, inhibiting monocarboxylate influx and efflux.	monocarboxylate	251-266	solute carrier family 16 member 3	Homo sapiens	186-190
26872974-1	2016	The transport of monocarboxylate fuels such as lactate, pyruvate, and ketone bodies across brain endothelial cells is mediated by monocarboxylic acid transporter 1 (MCT1).	monocarboxylate	17-32	solute carrier family 16 member 1	Rattus norvegicus	165-169
25482606-1	2015	This work reports the first example of a Zr-based MOF which is exclusively constructed from the monocarboxylate ligand formate.	monocarboxylate	96-111	lysine acetyltransferase 8	Homo sapiens	50-53
32144120-2	2020	MCTs 1-4 have been extensively studied and are involved in the proton-dependent transport of L-lactate, pyruvate, short-chain fatty acids, and monocarboxylate drugs in a wide variety of tissues.	monocarboxylate	143-158	solute carrier family 16 member 1	Homo sapiens	0-8
28421181-0	2017	MCT1 in Invasive Ductal Carcinoma: Monocarboxylate Metabolism and Aggressive Breast Cancer.	monocarboxylate	35-50	solute carrier family 16 member 1	Homo sapiens	0-4
27818323-5	2017	Probing the underlying mechanism in neurons, we identified the monocarboxylate lactate as a previously unrecognized potent and selective inducer of the CNS-specific PGC-1alpha isoforms.	monocarboxylate	63-78	PPARG coactivator 1 alpha	Homo sapiens	165-175
23384686-8	2013	Subsequent rescue experiments with capped mRNAs of specific isoforms further indicated that zMCT2 is an indispensable monocarboxylate-transporting route for CNS development and function in zebrafish.	monocarboxylate	118-133	solute carrier family 16 member 7	Danio rerio	92-97
24381558-7	2013	Major mechanisms for maintenance of pHi homeostasis include monocarboxylate, bicarbonate, and proton transporters.	monocarboxylate	60-75	glucose-6-phosphate isomerase	Homo sapiens	36-39
22700320-6	2012	RESULTS: In normoxia, both tumour cell types highly expressed the low affinity transporter MCT4, which is thought to mainly mediate monocarboxylate efflux, while for high affinity transport the breast tumour cells preferentially expressed MCT1 and the brain tumour cells resembled brain neurons in expressing MCT2, rather than MCT1.	monocarboxylate	132-147	solute carrier family 16 member 3	Homo sapiens	91-95
23106316-5	2012	The crystal structure of PDK1 in complex with compound 4h revealed that additional ionic interactions are mainly responsible for the increased potency compared to the monocarboxylate analogues.	monocarboxylate	167-182	pyruvate dehydrogenase kinase 1	Homo sapiens	25-29
22364841-4	2012	RESULTS: d-beta-Hydroxybutyrate, a normal ketone body metabolite, enters cells on the monocarboxylate transport mimicking the action of insulin and bypassing the enzymatic block at PDH.	monocarboxylate	86-101	insulin	Homo sapiens	136-143
22364841-4	2012	RESULTS: d-beta-Hydroxybutyrate, a normal ketone body metabolite, enters cells on the monocarboxylate transport mimicking the action of insulin and bypassing the enzymatic block at PDH.	monocarboxylate	86-101	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	181-184
17591909-13	2007	These studies suggest that SMCT1 and SMCT2 play a differential role in monocarboxylate transport in the retina in a cell type-specific manner.	monocarboxylate	71-86	solute carrier family 5 (sodium/glucose cotransporter), member 12	Mus musculus	37-42
21099300-1	2010	We have previously identified two genes, encoding lactate dehydrogenase (Ldha) and the monocarboxylate carrier, MCT1 (Slc16a1) whose expression is remarkably low in pancreatic beta-cells and islets.	monocarboxylate	87-102	modifier of curly tail 1	Mus musculus	112-116
21099300-1	2010	We have previously identified two genes, encoding lactate dehydrogenase (Ldha) and the monocarboxylate carrier, MCT1 (Slc16a1) whose expression is remarkably low in pancreatic beta-cells and islets.	monocarboxylate	87-102	solute carrier family 16 (monocarboxylic acid transporters), member 1	Mus musculus	118-125
20360908-8	2009	Lower monocarboxylate contents were found for MCT1 in both COPD #1 (63%) and COPD #2 (41%) and for MCT4 (78%) in COPD #1.	monocarboxylate	6-21	solute carrier family 16 member 1	Homo sapiens	46-50
20360908-8	2009	Lower monocarboxylate contents were found for MCT1 in both COPD #1 (63%) and COPD #2 (41%) and for MCT4 (78%) in COPD #1.	monocarboxylate	6-21	COPD1	Homo sapiens	59-66
20360908-8	2009	Lower monocarboxylate contents were found for MCT1 in both COPD #1 (63%) and COPD #2 (41%) and for MCT4 (78%) in COPD #1.	monocarboxylate	6-21	COPD2	Homo sapiens	77-84
17498214-1	2007	Synteny analysis is combined with sequence similarity and motif identification to trace the evolution of the putative monocarboxylate (lactate/pyruvate) transporters Jen1p and the dicarboxylate (succinate/fumarate/malate) transporters Jen2p in Hemiascomycetes yeasts and Euascomycetes fungi.	monocarboxylate	118-133	Jen1p	Saccharomyces cerevisiae S288C	166-171
21856423-1	2012	Monocarboxylate transporter 1 (MCT1) facilitates the transport of monocarboxylate fuels (lactate, pyruvate and ketone bodies) and acidic drugs, such as valproic acid, across cell membranes.	monocarboxylate	66-81	solute carrier family 16 member 1	Homo sapiens	0-29
21856423-1	2012	Monocarboxylate transporter 1 (MCT1) facilitates the transport of monocarboxylate fuels (lactate, pyruvate and ketone bodies) and acidic drugs, such as valproic acid, across cell membranes.	monocarboxylate	66-81	solute carrier family 16 member 1	Homo sapiens	31-35
19905008-2	2010	It was hypothesized that alterations in the [Ca2+](in) levels affect Na+-H+ exchanger (NHE) regulated pH(in) and thereby produce the proton-motivated driving force for monocarboxylate mediated substrate transport.	monocarboxylate	168-183	solute carrier family 9 member C1	Homo sapiens	87-90
19905008-12	2010	An understanding of the role of [Ca2+](in) in the MCT mediated transport process could provide an efficient strategy to improve the systemic delivery of monocarboxylate substrates through the cervical mucosa.	monocarboxylate	153-168	solute carrier family 16 member 1	Homo sapiens	50-53
18385447-13	2008	These striking differences between the two isoforms in expression localization and regulation suggest unique roles for each in monocarboxylate transport and pH regulation during preimplantation development, and implicate peroxisomal SLC16A7 as an important redox regulator in the absence of glucose.	monocarboxylate	127-142	solute carrier family 16 (monocarboxylic acid transporters), member 7	Mus musculus	233-240
16670197-5	2006	Here we demonstrate a high-affinity Na(+)-dependent monocarboxylate transport system in thyroid cells, which is likely to be SMCT.	monocarboxylate	52-67	solute carrier family 5 member 8	Homo sapiens	125-129
16621368-2	2006	However, the effects of monocarboxylate drugs, such as statins on the MCT4-mediated transport of L-lactic acid have not been elucidated.	monocarboxylate	24-39	solute carrier family 16 member 3	Homo sapiens	70-74
17245649-2	2007	To examine the involvement of human SMCT1, a Na+-coupled transporter for short-chain fatty acids, in the transport of nicotinate/structural analogs and monocarboxylate drugs, and to analyze its expression in mouse intestinal tract.	monocarboxylate	152-167	solute carrier family 5 member 8	Homo sapiens	36-41
17245649-13	2007	SMCT1 may participate in the intestinal absorption of monocarboxylate drugs.	monocarboxylate	54-69	solute carrier family 5 member 8	Homo sapiens	0-5
16514190-10	2006	The differential expression of MCT1 in the presence or absence of glucose demonstrates that it is important in the critical regulation of pH and monocarboxylate transport during preimplantation development, and implies a role for glucose in the control of MCT1, but not MCT3, expression.	monocarboxylate	145-160	modifier of curly tail 1	Mus musculus	31-35
16301311-3	2006	Here, by using the cytoplasmic pH indicator 2",7"-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein-acetoxymethyl ester, the initial rates of monocarboxylate-dependent cytoplasmic acidification were measured as an indication of MCT1 kinetic function in vitro using the rat brain endothelial cell (RBE4) model of blood-brain transport.	monocarboxylate	142-157	solute carrier family 16 member 1	Rattus norvegicus	228-232
16116050-10	2005	CONCLUSIONS: These data indicate that DNA methylation may modify monocarboxylate transport by suppressing MCT3 expression, which could be important in regulating SMC function and the development of atherosclerosis.	monocarboxylate	65-80	solute carrier family 16 member 3	Homo sapiens	106-110
15569267-3	2004	The transcript levels of GLUT1 and MCT1 in the RVEC fraction were the most abundant in the respective transporter family, suggesting that GLUT1 and MCT1 play a predominant role in d-glucose and monocarboxylate transport, respectively, at the inner BRB.	monocarboxylate	194-209	solute carrier family 2 member 1	Rattus norvegicus	25-30
15569267-3	2004	The transcript levels of GLUT1 and MCT1 in the RVEC fraction were the most abundant in the respective transporter family, suggesting that GLUT1 and MCT1 play a predominant role in d-glucose and monocarboxylate transport, respectively, at the inner BRB.	monocarboxylate	194-209	solute carrier family 16 member 1	Rattus norvegicus	35-39
15569267-3	2004	The transcript levels of GLUT1 and MCT1 in the RVEC fraction were the most abundant in the respective transporter family, suggesting that GLUT1 and MCT1 play a predominant role in d-glucose and monocarboxylate transport, respectively, at the inner BRB.	monocarboxylate	194-209	solute carrier family 2 member 1	Rattus norvegicus	138-143
15569267-3	2004	The transcript levels of GLUT1 and MCT1 in the RVEC fraction were the most abundant in the respective transporter family, suggesting that GLUT1 and MCT1 play a predominant role in d-glucose and monocarboxylate transport, respectively, at the inner BRB.	monocarboxylate	194-209	solute carrier family 16 member 1	Rattus norvegicus	148-152
16213084-9	2006	These results provide biochemical evidence of a H(+)-coupled and saturable transport system, presumed to be a low-affinity monocarboxylate transporter MCT4 or other unknown H(+)-coupled monocarboxylate transport system, for nicotinate in rat cerebrocortical astrocytes.	monocarboxylate	123-138	solute carrier family 16 member 3	Rattus norvegicus	151-155
15882471-10	2005	Furthermore, we suggest that the distribution characteristics of Slc5a8 along the intestinal tract render it a suitable candidate carrier for monocarboxylate drugs in the posterior portion of the intestine.	monocarboxylate	142-157	solute carrier family 5 (iodide transporter), member 8	Mus musculus	65-71
15450186-2	2004	The system is based on a Saccharomyces cerevisiae pyk1 mae1 jen1 triple-deletion strain that is auxotrophic for pyruvate and deficient in monocarboxylate uptake.	monocarboxylate	138-153	pyruvate kinase CDC19	Saccharomyces cerevisiae S288C	50-59
15450351-1	2004	Aquaporin 9 (AQP9) is a recently cloned water channel that is permeable to monocarboxylate, glycerol and urea.	monocarboxylate	75-90	aquaporin 9	Rattus norvegicus	0-11
15450351-1	2004	Aquaporin 9 (AQP9) is a recently cloned water channel that is permeable to monocarboxylate, glycerol and urea.	monocarboxylate	75-90	aquaporin 9	Rattus norvegicus	13-17
12946269-3	2003	We have mutated residues in this signature sequence in the rat monocarboxylate transporter (MCT1) to elucidate the significance of this region for monocarboxylate transport.	monocarboxylate	63-78	solute carrier family 16 member 1	Rattus norvegicus	92-96