PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 34293228-2 2021 We were successful in modifying a thrombin-binding aptamer with a red-light photocleavable linker derived from Cy7 by Cu-catalysed Click chemistry. cyanine dye 7 111-114 coagulation factor II, thrombin Homo sapiens 34-42 34782897-4 2021 The MPPF nanoprobes were constructed by the covalent functionalization of polydopamine (PDA) coated MoS2 nanosheets (NSs) with Cy7-labeled furin substrate peptides. cyanine dye 7 127-130 mago homolog, exon junction complex core component Mus musculus 100-104 34782897-4 2021 The MPPF nanoprobes were constructed by the covalent functionalization of polydopamine (PDA) coated MoS2 nanosheets (NSs) with Cy7-labeled furin substrate peptides. cyanine dye 7 127-130 furin (paired basic amino acid cleaving enzyme) Mus musculus 139-144 34782897-5 2021 Upon cleavage of the peptides by furin, Cy7 molecules are released from MPPF nanoprobes and recover their fluorescence, realizing furin activity detection with the limit of detection (LOD) down to 3.73 x 10-4 U mL-1. cyanine dye 7 40-43 furin (paired basic amino acid cleaving enzyme) Mus musculus 33-38 34845659-3 2021 PROCEDURES: Cell uptake of cyanine 7 (Cy7)-labeled TCP-1 probes (Cy7-PEG4-TCP-1 and Cy7-TCP-1) was investigated in three CRC cell lines (human, HCT116 and HT29; mouse, CT26). cyanine dye 7 38-41 t-complex 1 Homo sapiens 51-56 34782897-5 2021 Upon cleavage of the peptides by furin, Cy7 molecules are released from MPPF nanoprobes and recover their fluorescence, realizing furin activity detection with the limit of detection (LOD) down to 3.73 x 10-4 U mL-1. cyanine dye 7 40-43 furin (paired basic amino acid cleaving enzyme) Mus musculus 130-135 35445548-3 2022 Mesoporous silica NPs are used as a substrate for in situ deposition of PL nanodots of ZnGa2 O4 :Cr3+ to obtain mPL NPs, followed by surface grafting with silicon phthalocyanine (Si-Pc) and electrostatic assembly of cyanine 7 (Cy7) to fabricate mPL@Pc-Cy NPs. cyanine dye 7 227-230 myeloproliferative leukemia virus oncogene Mus musculus 72-74 35445548-3 2022 Mesoporous silica NPs are used as a substrate for in situ deposition of PL nanodots of ZnGa2 O4 :Cr3+ to obtain mPL NPs, followed by surface grafting with silicon phthalocyanine (Si-Pc) and electrostatic assembly of cyanine 7 (Cy7) to fabricate mPL@Pc-Cy NPs. cyanine dye 7 227-230 myeloproliferative leukemia virus oncogene Mus musculus 112-115 27574992-2 2016 The objective of this study was to characterize c[CTPSPFSHC]OH (TCP-1), a small peptide derived from phage display selection, for targeting human CRC xenografts using technetium-99m ((99m)Tc)-labeled TCP-1 and fluorescent cyanine-7 (Cy7)-labeled form of the peptide (Cy7-TCP-1). cyanine dye 7 233-236 t-complex 1 Homo sapiens 64-69 33795750-7 2021 The PASylated humanized Fab was site-specifically labelled with the fluorescent dye Cy7 and applied for the immuno-histochemical staining of human tissue sections representative for different TCs. cyanine dye 7 84-87 FA complementation group B Homo sapiens 24-27 31846890-8 2020 Moreover, we demonstrated the precise targeting of HACBC in vivo in apoE-/- mice by using HACBC coated with cy7. cyanine dye 7 108-111 apolipoprotein E Mus musculus 68-72 31676374-1 2020 A novel chemical-based orthogonal bioconjugation strategy to produce tri-functionalized nanoparticles (NPs) an chemotherapy drug, doxorubicin (DOX), a near-infrared cyanine dye (Cy7) and CRGDK homing peptide, a peptide specifically binds to neuropilin-1 (Nrp-1) overexpressed on triple negative breast cancer (TNBC) cells, has been validated. cyanine dye 7 178-181 neuropilin 1 Mus musculus 241-253 31676374-1 2020 A novel chemical-based orthogonal bioconjugation strategy to produce tri-functionalized nanoparticles (NPs) an chemotherapy drug, doxorubicin (DOX), a near-infrared cyanine dye (Cy7) and CRGDK homing peptide, a peptide specifically binds to neuropilin-1 (Nrp-1) overexpressed on triple negative breast cancer (TNBC) cells, has been validated. cyanine dye 7 178-181 neuropilin 1 Mus musculus 255-260 31246000-4 2019 Herein, we modified an indocyanine green derivative Cy7 with heavy atom iodine to form a novel NIR dye CyI to improve the reactive oxygen species (ROS) production and heat generation while, at the same time, maintain their fluorescence characteristics for in vivo noninvasive imaging. cyanine dye 7 52-55 cyclin I Homo sapiens 103-106 31288389-2 2019 Here, we further addressed the specificity and assessed the potential for arthritis monitoring using near-infrared fluorescence (NIRF) Cy7-labeled Vsig4 nanobody (Cy7-Nb119). cyanine dye 7 135-138 V-set and immunoglobulin domain containing 4 Mus musculus 147-152 30465921-4 2019 The resulting versatile nanoplatform GNR-HA-ALA/Cy7.5-HER2 had uniform sizes, favorable dispersibility, as well as pH, GSH and HAase triple-responsive drug release manner. cyanine dye 7 48-51 erb-b2 receptor tyrosine kinase 2 Homo sapiens 54-58 30465921-9 2019 The results suggest that the GNR-HA-ALA/Cy7.5-HER2 holds great potential for breast cancer therapy. cyanine dye 7 40-43 erb-b2 receptor tyrosine kinase 2 Homo sapiens 46-50 30465921-13 2019 We demonstrated that HER2 and CD44 receptors-mediated dual-targeting strategy significantly enhanced the cellular uptake of GNR-HA-ALA/Cy7.5-HER2. cyanine dye 7 135-138 erb-b2 receptor tyrosine kinase 2 Homo sapiens 21-25 30465921-13 2019 We demonstrated that HER2 and CD44 receptors-mediated dual-targeting strategy significantly enhanced the cellular uptake of GNR-HA-ALA/Cy7.5-HER2. cyanine dye 7 135-138 CD44 molecule (Indian blood group) Homo sapiens 30-34 30465921-13 2019 We demonstrated that HER2 and CD44 receptors-mediated dual-targeting strategy significantly enhanced the cellular uptake of GNR-HA-ALA/Cy7.5-HER2. cyanine dye 7 135-138 erb-b2 receptor tyrosine kinase 2 Homo sapiens 141-145 33397271-0 2021 99mTechnetium- or Cy7-Labeled Fab(Tocilizumab) as Potential Multiple Myeloma Imaging Agents. cyanine dye 7 18-21 FA complementation group B Homo sapiens 30-33 33397271-4 2021

Objective: We aim to label and evaluate Fab(Tocilizumab) with 99mTechnetium or Cy7 as potential MM imaging agents. cyanine dye 7 83-86 FA complementation group B Homo sapiens 44-47 33397271-9 2021 Also, Fab(Tocilizumab) was labeled with Cy7 for in vivo fluorescence imaging up to 72 h. RESULTS: LCM analysis demonstrates IL-6R distribution on MM cell lines. cyanine dye 7 40-43 FA complementation group B Homo sapiens 6-9 33397271-9 2021 Also, Fab(Tocilizumab) was labeled with Cy7 for in vivo fluorescence imaging up to 72 h. RESULTS: LCM analysis demonstrates IL-6R distribution on MM cell lines. cyanine dye 7 40-43 interleukin 6 receptor Homo sapiens 124-129 33263448-3 2020 To confirm the accuracy of the spatial localization and demonstrate the ability to image locoregionally delivered therapies, we labeled mouse albumin with Cy7 (Cy7ALB) and delivered it via locoregional infusion 1 mm or 3 mm into the brain and demonstrated correlation of signal between the 3D OI/CT and post necropsy brain slices. cyanine dye 7 155-158 albumin Mus musculus 142-149 33263448-7 2020 Furthermore, we demonstrated that 3D OI/CT can also image the therapeutic distribution of a Cy7-labeled anti-PD-1 antibody, a prototype translational antibody therapy. cyanine dye 7 92-95 programmed cell death 1 Mus musculus 109-113 33048944-7 2020 In the present study, we designed a probe using Polyamidoamine (PAMAM) fifth-generation (G5) dendrimers conjugated with mannose, Cyanine 7 (Cy7), and hydrazinonicotinamide (HYNIC) for target macrophages with high expression of MRC1 in the tumor. cyanine dye 7 140-143 mannose receptor C-type 1 Homo sapiens 227-231 30296375-3 2018 The well-characterized CE7Ns can release erlotinib and Cy7 fast under acidic condition in the presence of lysozyme, distinguish three molecular subtypes of NSCLC, and specifically bind to the erlotinib-sensitive epidermal growth factor receptor (EGFR)-mutated PC-9 cells. cyanine dye 7 55-58 epidermal growth factor receptor Homo sapiens 212-244 28819447-4 2017 Methods The scFvGPIIb/IIIa, which binds specifically to the activated form of the platelet integrin receptor GPIIb/IIIa present on activated platelets, was conjugated to either Cy7, 64Cu or ultrasound-enhancing microbubbles. cyanine dye 7 177-180 integrin subunit alpha 2b Homo sapiens 16-21 25319581-1 2015 BACKGROUND: The aim of this study was to evaluate the efficacy of using matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9)-cleavable ratiometric activatable cell-penetrating peptides (RACPPs) conjugated to Cy5 and Cy7 fluorophores to accurately label pancreatic cancer for fluorescence-guided surgery (FGS) in an orthotopic mouse model. cyanine dye 7 237-240 matrix metallopeptidase 9 Mus musculus 111-137 25319581-1 2015 BACKGROUND: The aim of this study was to evaluate the efficacy of using matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9)-cleavable ratiometric activatable cell-penetrating peptides (RACPPs) conjugated to Cy5 and Cy7 fluorophores to accurately label pancreatic cancer for fluorescence-guided surgery (FGS) in an orthotopic mouse model. cyanine dye 7 237-240 matrix metallopeptidase 9 Mus musculus 139-144 23755836-1 2013 A near-infrared fluorescent dye Hsd was designed and synthesized, which absorbed as hemicyane and emitted as Cy7 and therefore produced a Stokes shift as large as 224 nm. cyanine dye 7 109-112 carbohydrate sulfotransferase 3 Homo sapiens 32-35 25043572-4 2014 In vivo, VCAM-1 targeted and Cy7-labeled peptide amphiphile micelles were shown to specifically accumulate at atherosclerotic plaques in both early and mid-stage ApoE -/- mice through co-localization of Cy7 signal with anti-VCAM-1 antibody staining in fixed tissue. cyanine dye 7 29-32 apolipoprotein E Mus musculus 162-166 25043572-4 2014 In vivo, VCAM-1 targeted and Cy7-labeled peptide amphiphile micelles were shown to specifically accumulate at atherosclerotic plaques in both early and mid-stage ApoE -/- mice through co-localization of Cy7 signal with anti-VCAM-1 antibody staining in fixed tissue. cyanine dye 7 203-206 vascular cell adhesion molecule 1 Mus musculus 9-15 24833041-0 2014 Near-infrared fluorescence imaging of non-Hodgkin"s lymphoma CD20 expression using Cy7-conjugated obinutuzumab. cyanine dye 7 83-86 membrane spanning 4-domains A1 Homo sapiens 61-65 23539220-6 2013 Additional near-infrared fluorescent imaging at a longer wavelength (Cy7) with a cathepsin-B-sensing activatable molecular imaging agent showed attenuation of cathepsin-B-related signal in the L-SR15 group. cyanine dye 7 69-72 cathepsin B Mus musculus 81-92 23539220-6 2013 Additional near-infrared fluorescent imaging at a longer wavelength (Cy7) with a cathepsin-B-sensing activatable molecular imaging agent showed attenuation of cathepsin-B-related signal in the L-SR15 group. cyanine dye 7 69-72 cathepsin B Mus musculus 159-170 21612822-3 2011 EphB4-binding peptide TNYL-FSPNGPIARAW (TNYL-RAW) was conjugated to polyethylene glycol-coated, core-crosslinked polymeric micelles (CCPM) dually labeled with near-infrared fluorescence fluorophores (Cy7) and a radioisotope (indium 111). cyanine dye 7 200-203 Eph receptor B4 Mus musculus 0-5 18273706-6 2008 P-selectin expression was assessed with near-infrared imaging using Cy7 labeled antibody, and gamma camera imaging using( 111)In-DTPA labeled antibody. cyanine dye 7 68-71 selectin, platelet Mus musculus 0-10 17982120-10 2007 Twenty-four hours after injection, A431 and NIH3T3/HER2+ tumors were detected distinctly by their peak on Cy5.5 and Cy7 spectral images, respectively; radionuclide imaging was unable to clearly distinguish tumors at this time point. cyanine dye 7 116-119 erb-b2 receptor tyrosine kinase 2 Mus musculus 51-55 16791749-0 2006 Near-infrared fluorescence imaging of tumor integrin alpha v beta 3 expression with Cy7-labeled RGD multimers. cyanine dye 7 84-87 integrin subunit alpha V Homo sapiens 44-67 10477448-3 1999 RESULTS: The number of CD34+ cells collected per liter of processed blood was significantly higher in the CY7+G-CSF group than in the CY4+G-CSF and G-CSF groups (p </= .005), but not the IVE+G-CSF group. cyanine dye 7 106-109 CD34 molecule Homo sapiens 23-27