PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 29146047-4 2018 RESULTS: Prenatal exposure to polyinosinic:polycytidylic acid causes an imbalanced expression of the Na+-K+-2Cl- cotransporter 1 and the K+-Cl- cotransporter 2 (KCC2). Poly C 43-61 solute carrier family 12, member 5 Mus musculus 137-159 29146047-4 2018 RESULTS: Prenatal exposure to polyinosinic:polycytidylic acid causes an imbalanced expression of the Na+-K+-2Cl- cotransporter 1 and the K+-Cl- cotransporter 2 (KCC2). Poly C 43-61 solute carrier family 12, member 5 Mus musculus 161-165 28974092-3 2017 Here, we investigated the ability of chitosan-based nanoparticles (pIC-NPs) containing polyinosinic-polycytidylic acid (poly(I:C)), an inducer of innate immunity via Toll-like receptor 3 (TLR3), to enhance the immunogenicity of BCG in mouse bone marrow derived macrophages (BMDM) in vitro. Poly C 99-118 toll-like receptor 3 Mus musculus 166-186 29277364-7 2018 Here we report the clear induction of sb-isg15 transcript levels in SAF-1 cells and AGs stimulated with toll-like receptor (TLR) ligands, such as polyinosinic:polycytidylic acid (poly I:C) or genomic DNA from Vibrio anguillarum (VaDNA), respectively. Poly C 159-177 ISG15 ubiquitin like modifier Homo sapiens 41-46 28921679-3 2018 This study systematically investigated how maternal immune activation (MIA; a risk factor for schizophrenia) induced by polyinosinic:polycytidylic acid affected nNOS-immunoreactivity in the brain of the resulting male and female offspring at the age of postnatal day (PND) 2. Poly C 133-151 nitric oxide synthase 1 Rattus norvegicus 161-165 28978569-7 2017 Although recipient exposure to the viral-like adjuvant polyinosinic:polycytidylic acid enhanced anti-FVIII antibody formation, MZ B-cell depletion continued to display similar effectiveness in preventing inhibitor formation following FVIII infusion in this inflammatory setting. Poly C 68-86 coagulation factor VIII Homo sapiens 101-106 27086952-3 2017 Polyriboinosinic:polyribocytidylic acid (poly (I:C)), a synthetic analog of viral RNA, induces a Toll-like receptor 3 (TLR3)-dependent arteriolar thrombosis without significant thrombus formation in venules in vivo. Poly C 17-39 toll like receptor 3 Homo sapiens 97-117 27086952-3 2017 Polyriboinosinic:polyribocytidylic acid (poly (I:C)), a synthetic analog of viral RNA, induces a Toll-like receptor 3 (TLR3)-dependent arteriolar thrombosis without significant thrombus formation in venules in vivo. Poly C 17-39 toll like receptor 3 Homo sapiens 119-123 28849057-1 2017 The present study aimed to determine the underlying mechanism of toll-like receptor (TLR) agonist polyinosinic:polycytidylic acid (Poly I:C)-induced apoptosis in THP-1 cells following silencing the expression of tumor necrosis factor alpha-induced protein 8-like 2 (TIPE2). Poly C 111-129 TNF alpha induced protein 8 like 2 Homo sapiens 212-264 28849057-1 2017 The present study aimed to determine the underlying mechanism of toll-like receptor (TLR) agonist polyinosinic:polycytidylic acid (Poly I:C)-induced apoptosis in THP-1 cells following silencing the expression of tumor necrosis factor alpha-induced protein 8-like 2 (TIPE2). Poly C 111-129 TNF alpha induced protein 8 like 2 Homo sapiens 266-271 27748915-1 2016 Poly(C)-binding protein 2 (PCBP2) is a member of the PCBP family, and plays an important role in post-transcriptional and translational regulation of various signaling molecules through direct binding to single-stranded poly(C) motifs. Poly C 220-227 poly(rC) binding protein 2 Homo sapiens 0-25 28717003-2 2017 Double-stranded RNA and the synthetic analog polyinosinic:polycytidylic acid (poly(I:C)) bind and activate TLR3. Poly C 58-76 toll like receptor 3 Homo sapiens 107-111 27649928-3 2017 Intraperitoneally injected polyribocytidylic acid (poly (I:C)- (a ligand of TLR3) primed human umbilical cord-derived MSCs (hUC-MSCs) migrated to the inflamed colon and effectively improved clinical and pathological manifestations in colitic mice compared with mice treated with unstimulated hUC-MSCs (UCMs). Poly C 27-49 toll like receptor 3 Homo sapiens 76-80 27911568-3 2017 Although acute activation of the Toll-like receptor (TLR) 3 pathway by extracellular polyinosinic:polycytidylic acid (poly[I:C]) induces innate signaling through the NF-kappaB transcription factor in normal human small airway epithelial cells, prolonged (repetitive or tonic) poly(I:C) stimulation produces chronic stress fiber formation, mesenchymal transition, and activation of a fibrotic program. Poly C 98-116 nuclear factor kappa B subunit 1 Homo sapiens 166-175 28331190-9 2017 Moreover, we found that IFN-gamma production from NK cells was essential for the antiviral effect of PolyI:C in the model. Poly C 101-108 interferon gamma Homo sapiens 24-33 28266599-6 2017 After stimulation of ORS cells with the double-stranded (ds)RNA mimic polyinosinic:polycytidylic acid (poly[I:C]), the activation of caspase-1 and secretion of IL-1beta were enhanced. Poly C 83-101 caspase 1 Homo sapiens 133-142 28266599-6 2017 After stimulation of ORS cells with the double-stranded (ds)RNA mimic polyinosinic:polycytidylic acid (poly[I:C]), the activation of caspase-1 and secretion of IL-1beta were enhanced. Poly C 83-101 interleukin 1 beta Homo sapiens 160-168 29204085-4 2017 In this study we demonstrate that IC or intravenous immunoglobulin (Ig) stimulation of B cells attenuates polyinosinic:polycytidylic acid (poly I:C)-induced CD40 expression; IC, but not Ig, can significantly inhibit poly I:C-induced pro-inflammatory tumour necrosis factor alpha (TNF-alpha) production by B cells. Poly C 119-137 CD40 molecule Homo sapiens 157-161 29204085-4 2017 In this study we demonstrate that IC or intravenous immunoglobulin (Ig) stimulation of B cells attenuates polyinosinic:polycytidylic acid (poly I:C)-induced CD40 expression; IC, but not Ig, can significantly inhibit poly I:C-induced pro-inflammatory tumour necrosis factor alpha (TNF-alpha) production by B cells. Poly C 119-137 tumor necrosis factor Homo sapiens 280-289 28809156-0 2017 The length of poly(C) stretch in the Bordetella pertussis Pfim3 promoter determines the vag or vrg function of the fim3 gene. Poly C 14-21 FIM3 Homo sapiens 59-63 28809156-2 2017 The expression of fim2 and fim3 is regulated by the BvgAS two-component system and the length of poly(C) stretches in Pfim promoters. Poly C 97-104 colony stimulating factor 1 receptor Homo sapiens 18-22 28809156-2 2017 The expression of fim2 and fim3 is regulated by the BvgAS two-component system and the length of poly(C) stretches in Pfim promoters. Poly C 97-104 FIM3 Homo sapiens 27-31 28809156-6 2017 Our findings indicate that fim2 is a vag, while fim3 is a vag when Pfim3 poly(C)>13C, and a vrg when poly(C)<=13C. Poly C 73-79 FIM3 Homo sapiens 48-52 28809156-6 2017 Our findings indicate that fim2 is a vag, while fim3 is a vag when Pfim3 poly(C)>13C, and a vrg when poly(C)<=13C. Poly C 104-110 FIM3 Homo sapiens 48-52 28809156-7 2017 Although increased fim3 expression was observed in the Bvg- phase in isolates with Pfim3 poly(C)<=13C, Fim3 production was not detected, suggesting post-transcriptional regulation of fim3 expression. Poly C 89-95 FIM3 Homo sapiens 19-23 28809156-7 2017 Although increased fim3 expression was observed in the Bvg- phase in isolates with Pfim3 poly(C)<=13C, Fim3 production was not detected, suggesting post-transcriptional regulation of fim3 expression. Poly C 89-95 FIM3 Homo sapiens 84-88 28466996-3 2017 METHOD OF STUDY: The aims of this study were to determine the effect of: (i) viral dsRNA analogue polyinosinic:polycytidylic acid (poly(I:C)) on HAVCR2 expression; and (ii) HAVCR2 silencing by siRNA (siHAVCR2) in primary amnion and myometrial cells on poly(I:C)-induced inflammation. Poly C 111-129 hepatitis A virus cellular receptor 2 Homo sapiens 145-151 28381556-0 2017 Poly(C)-binding protein 1 (Pcbp1) regulates skeletal muscle differentiation by modulating microRNA processing in myoblasts. Poly C 0-6 poly(rC) binding protein 1 Mus musculus 27-32 28411188-3 2017 RKIP deficiency or silencing significantly decreases polyinosinic:polycytidylic acid [Poly(I:C)]-induced IFN-beta, IL-6, and TNF-alpha production without affecting the counterpart induced by LPS or CpG. Poly C 66-84 interferon beta 1, fibroblast Mus musculus 105-113 28411188-3 2017 RKIP deficiency or silencing significantly decreases polyinosinic:polycytidylic acid [Poly(I:C)]-induced IFN-beta, IL-6, and TNF-alpha production without affecting the counterpart induced by LPS or CpG. Poly C 66-84 interleukin 6 Mus musculus 115-119 28411188-3 2017 RKIP deficiency or silencing significantly decreases polyinosinic:polycytidylic acid [Poly(I:C)]-induced IFN-beta, IL-6, and TNF-alpha production without affecting the counterpart induced by LPS or CpG. Poly C 66-84 tumor necrosis factor Mus musculus 125-134 28272528-6 2017 Degradation of Poly(A), Poly(C), Poly(G), Poly(I), Poly(T), and Poly(U) oligomers in the presence of EGFR and ATP correlated with the lower ability of reaction products to pair with complementary oligonucleotides. Poly C 24-30 epidermal growth factor receptor Homo sapiens 101-105 28292465-3 2017 Thus, the aims of this study were to determine the effect of the bacterial product lipopolysaccharide (LPS) or the viral dsRNA analogue polyinosinic:polycytidylic acid (poly(I:C)) on the insulin signalling pathway and amino acid transport in primary human trophoblast cells. Poly C 149-167 insulin Homo sapiens 187-194 28149670-9 2016 Injection with polyinosinic: polycytidylic acid (poly I:C), a synthetic analogue of double stranded viral RNA that binds Toll-Like Receptor-3 (TLR3), also regulated gene expressions of CCKAR and proinflammatory cytokines, in the different breeds. Poly C 49-57 toll like receptor 3 Gallus gallus 121-141 28149670-9 2016 Injection with polyinosinic: polycytidylic acid (poly I:C), a synthetic analogue of double stranded viral RNA that binds Toll-Like Receptor-3 (TLR3), also regulated gene expressions of CCKAR and proinflammatory cytokines, in the different breeds. Poly C 49-57 toll like receptor 3 Gallus gallus 143-147 28149670-9 2016 Injection with polyinosinic: polycytidylic acid (poly I:C), a synthetic analogue of double stranded viral RNA that binds Toll-Like Receptor-3 (TLR3), also regulated gene expressions of CCKAR and proinflammatory cytokines, in the different breeds. Poly C 49-57 cholecystokinin A receptor Gallus gallus 185-190 27623813-9 2016 Notably, polyinosinic:polycytidylic acid induced nuclear localization of iNOS, and its binding to, and nitrosylation of, the epigenetic modifier ring finger protein 1A (RING1A) as assessed by immunostaining, Co-IP, and mass spectrometry. Poly C 22-40 nitric oxide synthase 2, inducible Mus musculus 73-77 27623813-9 2016 Notably, polyinosinic:polycytidylic acid induced nuclear localization of iNOS, and its binding to, and nitrosylation of, the epigenetic modifier ring finger protein 1A (RING1A) as assessed by immunostaining, Co-IP, and mass spectrometry. Poly C 22-40 ring finger protein 1 Mus musculus 145-167 27623813-9 2016 Notably, polyinosinic:polycytidylic acid induced nuclear localization of iNOS, and its binding to, and nitrosylation of, the epigenetic modifier ring finger protein 1A (RING1A) as assessed by immunostaining, Co-IP, and mass spectrometry. Poly C 22-40 ring finger protein 1 Mus musculus 169-175 27748915-1 2016 Poly(C)-binding protein 2 (PCBP2) is a member of the PCBP family, and plays an important role in post-transcriptional and translational regulation of various signaling molecules through direct binding to single-stranded poly(C) motifs. Poly C 220-227 poly(rC) binding protein 2 Homo sapiens 27-32 27603520-3 2016 The long double-stranded RNA (dsRNA) viral mimic, polyinosinic polycytidylic acid (polyIC, PIC) potently stimulates DCs to focus Th1 responses, triggers direct antiviral activity in vitro, and boosts anti-HIV responses in vivo. Poly C 83-89 negative elongation factor complex member C/D Homo sapiens 129-132 27601297-6 2016 Moreover, Ec-MKK7 was universally expressed in all examined tissues and showed expression modulation to challenges of lipopolysacchride (LPS), Singapore grouper iridovirus (SGIV) and polyriboinosinic polyribocytidylic acid (poly I:C) in vivo. Poly C 224-232 mitogen-activated protein kinase kinase 7 Homo sapiens 13-17 27209304-1 2016 PCBP2, a member of the poly(C)-binding protein (PCBP) family, plays a pivotal role in posttranscriptional and translational regulation by interacting with single-stranded poly(C) motifs in target mRNAs. Poly C 23-30 poly(rC) binding protein 2 Homo sapiens 0-5 27412245-16 2016 MAIN RESULTS AND THE ROLE OF CHANCE: Our results showed that addition of polyinosinic:polycytidylic acid (Poly I:C) to RL95-2 cells significantly increased the production of IL-1RA (P < 0.05). Poly C 86-104 interleukin 1 receptor antagonist Homo sapiens 174-180 27198486-2 2016 We found that Toll-like receptor (TLR) stimuli, particularly the viral mimetic polyinosinic:polycytidylic acid (poly(I:C)), specifically induce ApoLs7/11 subfamilies in murine CD8alpha(+) dendritic cells (DCs). Poly C 92-110 CD8 antigen, alpha chain Mus musculus 176-184 27621733-8 2016 IFNalpha/beta increase HSC proliferation in models of sterile inflammation induced by polyinosinic:polycytidylic acid and lead to BM aplasia during viral infection. Poly C 99-117 interferon alpha 1 Homo sapiens 0-8 26994222-4 2016 First, the upregulation of IFNphi1 promoter activity stimulated by polyinosinic:polycytidylic acid, retinoic acid-inducible gene I (RIG-I) or MAVS was suppressed by the SVCV infection. Poly C 80-98 interferon phi 1 Danio rerio 27-34 27327127-6 2016 The MDA5 promoter activity was extremely low under basal condition, but was dramatically increased when cells were stimulated with polyinosinic: polycytidylic acid (poly I:C), interferon beta (IFN-beta) or Infectious Bursal Disease Virus (IBDV). Poly C 165-173 interferon induced with helicase C domain 1 Gallus gallus 4-8 27461833-0 2016 Poly (C)-binding protein 2 (PCBP2) promotes the progression of esophageal squamous cell carcinoma (ESCC) through regulating cellular proliferation and apoptosis. Poly C 0-7 poly(rC) binding protein 2 Homo sapiens 28-33 27461833-1 2016 PCBP2 (Poly(C)-binding protein 2) is a member of PCBP family, which has many functions including mRNA stabilization, translational silence and translational enhancement performed by their poly(C)-binding ability. Poly C 188-195 poly(rC) binding protein 2 Homo sapiens 0-5 27461833-1 2016 PCBP2 (Poly(C)-binding protein 2) is a member of PCBP family, which has many functions including mRNA stabilization, translational silence and translational enhancement performed by their poly(C)-binding ability. Poly C 188-195 poly(rC) binding protein 2 Homo sapiens 7-32 27151946-5 2016 The effects of p31-43 were dependent on MyD88 and type I IFNs, but not Toll-like receptor 4 (TLR4), and were enhanced by coadministration of the TLR3 agonist polyinosinic:polycytidylic acid. Poly C 171-189 unconventional SNARE in the ER 1 homolog (S. cerevisiae) Mus musculus 15-18 27151946-5 2016 The effects of p31-43 were dependent on MyD88 and type I IFNs, but not Toll-like receptor 4 (TLR4), and were enhanced by coadministration of the TLR3 agonist polyinosinic:polycytidylic acid. Poly C 171-189 toll-like receptor 3 Mus musculus 145-149 27373927-4 2016 We present here two of these issues related to the use of Mx1-Cre: first, a high spontaneous recombination rate when applying commonly used techniques in experimental hematology, and second, undesired short-term consequences of the use of polyinosinic:polycytidylic acid, including changes in cellular phenotypes that, however, resolve within days. Poly C 252-270 MX dynamin-like GTPase 1 Mus musculus 58-61 26935338-3 2016 In addition, Muc1 + polyinosinic:polycytidylic acid (poly I:C) was found to stimulate the expression levels of the surface molecules cluster of differentiation (CD)40, CD83 and CD80, and HLA-DRm and decreased the expression of CD14 in the dendritic cells, determined using fluorescence-activated cell sorting. Poly C 33-51 mucin 1, cell surface associated Homo sapiens 13-17 26880484-1 2016 Accumulating evidences indicate that poly C binding protein (PCBP1) is downregulated in various carcinomas as a tumor suppressor, but the underlying mechanism in suppression of tumorigenesis still remains elusive. Poly C 37-43 poly(rC) binding protein 1 Homo sapiens 61-66 26935338-3 2016 In addition, Muc1 + polyinosinic:polycytidylic acid (poly I:C) was found to stimulate the expression levels of the surface molecules cluster of differentiation (CD)40, CD83 and CD80, and HLA-DRm and decreased the expression of CD14 in the dendritic cells, determined using fluorescence-activated cell sorting. Poly C 33-51 CD83 molecule Homo sapiens 168-172 26935338-3 2016 In addition, Muc1 + polyinosinic:polycytidylic acid (poly I:C) was found to stimulate the expression levels of the surface molecules cluster of differentiation (CD)40, CD83 and CD80, and HLA-DRm and decreased the expression of CD14 in the dendritic cells, determined using fluorescence-activated cell sorting. Poly C 33-51 CD80 molecule Homo sapiens 177-181 26935338-3 2016 In addition, Muc1 + polyinosinic:polycytidylic acid (poly I:C) was found to stimulate the expression levels of the surface molecules cluster of differentiation (CD)40, CD83 and CD80, and HLA-DRm and decreased the expression of CD14 in the dendritic cells, determined using fluorescence-activated cell sorting. Poly C 33-51 CD14 molecule Homo sapiens 227-231 26659307-6 2015 RESULTS: Polyinosinic:polycytidylic acid transfection led to elevated expression of the genes encoding IFNalpha, IFNbeta, CXCL10, Fas, viral receptors, and IFN-inducible antiviral effectors in MIN6 cells. Poly C 22-40 interferon alpha Mus musculus 103-111 26549174-9 2016 In gill tissues, the temporally induced mRNA expression of Of-Pis1, upon in vivo injection trials with lipopolysaccharide (LPS); polyinosinic:polycytidylic acid (poly I:C); and pathogens, including Edwardsiella tarda, Streptococcus iniae, and rock bream iridovirus (RBIV), was weak. Poly C 142-160 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 62-66 26674566-6 2016 The proinflammatory cytokine IL1B, the bacterial product fsl-1, and viral analog polyinosinic:polycytidylic acid (poly [I:C]) significantly increased IRF1 mRNA expression and transcriptional activity in human primary myometrial cells. Poly C 94-112 interleukin 1 beta Homo sapiens 29-33 26674566-6 2016 The proinflammatory cytokine IL1B, the bacterial product fsl-1, and viral analog polyinosinic:polycytidylic acid (poly [I:C]) significantly increased IRF1 mRNA expression and transcriptional activity in human primary myometrial cells. Poly C 94-112 interferon regulatory factor 1 Homo sapiens 150-154 26759009-5 2016 In this study, we analyzed the potential of polyinosinic:polycytidylic acid [poly(I:C)], a TLR3 agonist, to replace or complement BCG in the treatment of non-muscle-invasive bladder cancer. Poly C 57-75 toll like receptor 3 Homo sapiens 91-95 26744891-0 2016 Correction: Human beta-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid. Poly C 124-142 toll like receptor 3 Homo sapiens 59-63 26659307-6 2015 RESULTS: Polyinosinic:polycytidylic acid transfection led to elevated expression of the genes encoding IFNalpha, IFNbeta, CXCL10, Fas, viral receptors, and IFN-inducible antiviral effectors in MIN6 cells. Poly C 22-40 interferon beta 1, fibroblast Mus musculus 113-120 26659307-6 2015 RESULTS: Polyinosinic:polycytidylic acid transfection led to elevated expression of the genes encoding IFNalpha, IFNbeta, CXCL10, Fas, viral receptors, and IFN-inducible antiviral effectors in MIN6 cells. Poly C 22-40 chemokine (C-X-C motif) ligand 10 Mus musculus 122-128 26646717-0 2015 Human beta-Defensin 3 [corrected] Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid. Poly C 131-149 defensin beta 103B Homo sapiens 6-21 26646717-5 2015 HBD3 exacerbated the production of type I Interferon-beta in response to the viral ligand mimic polyinosinic:polycytidylic acid (polyI:C) in both human and mouse primary cells, although production of the chemokine CXCL10 was suppressed. Poly C 109-127 defensin beta 103B Homo sapiens 0-4 26646717-5 2015 HBD3 exacerbated the production of type I Interferon-beta in response to the viral ligand mimic polyinosinic:polycytidylic acid (polyI:C) in both human and mouse primary cells, although production of the chemokine CXCL10 was suppressed. Poly C 109-127 interferon beta 1, fibroblast Mus musculus 42-57 26124281-5 2015 Induced ablation of SRSF2 in adult Mx1-Cre Srsf2(flox/flox) mice upon poly(I):poly(C) injection demonstrated a significant decrease in lineage(-) Sca(+) c-Kit(+) cells in bone marrow. Poly C 78-85 serine and arginine-rich splicing factor 2 Mus musculus 20-25 26573531-0 2015 PHF11 expression and cellular distribution is regulated by the Toll-Like Receptor 3 Ligand Polyinosinic:Polycytidylic Acid in HaCaT keratinocytes. Poly C 104-122 PHD finger protein 11 Homo sapiens 0-5 26573531-0 2015 PHF11 expression and cellular distribution is regulated by the Toll-Like Receptor 3 Ligand Polyinosinic:Polycytidylic Acid in HaCaT keratinocytes. Poly C 104-122 toll like receptor 3 Homo sapiens 63-83 26143480-2 2015 One subgroup in mammalian cells are the Poly(C)-binding proteins (PCBPs) comprised of hnRNP K/J and hnRNP E1-4 [the latter also known as PCBP 1-4 or alpha-complex proteins (alpha-CP) 1-4]. Poly C 40-47 heterogeneous nuclear ribonucleoprotein K Homo sapiens 86-93 26143480-2 2015 One subgroup in mammalian cells are the Poly(C)-binding proteins (PCBPs) comprised of hnRNP K/J and hnRNP E1-4 [the latter also known as PCBP 1-4 or alpha-complex proteins (alpha-CP) 1-4]. Poly C 40-47 poly(rC) binding protein 1 Homo sapiens 100-110 26143480-2 2015 One subgroup in mammalian cells are the Poly(C)-binding proteins (PCBPs) comprised of hnRNP K/J and hnRNP E1-4 [the latter also known as PCBP 1-4 or alpha-complex proteins (alpha-CP) 1-4]. Poly C 40-47 poly(rC) binding protein 1 Homo sapiens 137-143 26722446-1 2015 PCBP2, a member of the poly(C)-binding protein (PCBP) family, is involved in posttranscriptional and translational regulation by interacting with single-stranded poly(C) motifs in target mRNAs. Poly C 23-30 poly(rC) binding protein 2 Homo sapiens 0-5 26527618-0 2016 The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development. Poly C 4-11 poly(rC) binding protein 2 Mus musculus 28-33 26527618-0 2016 The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development. Poly C 4-11 poly(rC) binding protein 1 Mus musculus 69-74 26283481-0 2015 Stimulation of the RIG-I/MAVS Pathway by Polyinosinic:Polycytidylic Acid Upregulates IFN-beta in Airway Epithelial Cells with Minimal Costimulation of IL-8. Poly C 54-72 DExD/H-box helicase 58 Homo sapiens 19-24 26283481-0 2015 Stimulation of the RIG-I/MAVS Pathway by Polyinosinic:Polycytidylic Acid Upregulates IFN-beta in Airway Epithelial Cells with Minimal Costimulation of IL-8. Poly C 54-72 mitochondrial antiviral signaling protein Homo sapiens 25-29 26283481-0 2015 Stimulation of the RIG-I/MAVS Pathway by Polyinosinic:Polycytidylic Acid Upregulates IFN-beta in Airway Epithelial Cells with Minimal Costimulation of IL-8. Poly C 54-72 interferon beta 1 Homo sapiens 85-93 26124281-5 2015 Induced ablation of SRSF2 in adult Mx1-Cre Srsf2(flox/flox) mice upon poly(I):poly(C) injection demonstrated a significant decrease in lineage(-) Sca(+) c-Kit(+) cells in bone marrow. Poly C 78-85 MX dynamin-like GTPase 1 Mus musculus 35-38 25679777-4 2015 Immunization of BALB/c mice with the recombinant mAb in the presence of polyriboinosinic: polyribocytidylic acid (poly (I:C)) specifically enhanced the number of IFN-gamma producing cells and CD4+ T cell proliferation when compared to mice immunized with a mAb without receptor affinity or with the non-targeted ASP-2 protein. Poly C 90-112 interferon gamma Mus musculus 162-171 26293996-1 2015 BACKGROUND: Depletion of Poly-C binding protein-1(PCBP1) is implicated in various human malignancies. Poly C 25-31 poly(rC) binding protein 1 Homo sapiens 50-55 26094120-6 2015 Rhein also inhibited SRA ligand polyinosinic:polycytidylic acid (poly(I:C)) induced activation of transcriptional factors, including interferon regulatory factor 3 (IRF3) and signal transducer and activator of transcription 1 (STAT1). Poly C 45-63 macrophage scavenger receptor 1 Homo sapiens 21-24 26094120-6 2015 Rhein also inhibited SRA ligand polyinosinic:polycytidylic acid (poly(I:C)) induced activation of transcriptional factors, including interferon regulatory factor 3 (IRF3) and signal transducer and activator of transcription 1 (STAT1). Poly C 45-63 interferon regulatory factor 3 Homo sapiens 133-163 26094120-6 2015 Rhein also inhibited SRA ligand polyinosinic:polycytidylic acid (poly(I:C)) induced activation of transcriptional factors, including interferon regulatory factor 3 (IRF3) and signal transducer and activator of transcription 1 (STAT1). Poly C 45-63 interferon regulatory factor 3 Homo sapiens 165-169 26094120-6 2015 Rhein also inhibited SRA ligand polyinosinic:polycytidylic acid (poly(I:C)) induced activation of transcriptional factors, including interferon regulatory factor 3 (IRF3) and signal transducer and activator of transcription 1 (STAT1). Poly C 45-63 signal transducer and activator of transcription 1 Homo sapiens 175-225 26094120-6 2015 Rhein also inhibited SRA ligand polyinosinic:polycytidylic acid (poly(I:C)) induced activation of transcriptional factors, including interferon regulatory factor 3 (IRF3) and signal transducer and activator of transcription 1 (STAT1). Poly C 45-63 signal transducer and activator of transcription 1 Homo sapiens 227-232 26243192-3 2015 We showed that the mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK) apoptosis signal-regulating kinase 1 (ASK1) was activated in cells by the synthetic double-stranded RNA analog polyinosinic:polycytidylic acid [poly(I:C)] and by RNA viruses, and that ASK1 played an essential role in both the induction of the gene encoding IFN-beta (IFNB) and apoptotic cell death. Poly C 206-224 mitogen-activated protein kinase kinase kinase 4 Homo sapiens 74-80 26243192-3 2015 We showed that the mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK) apoptosis signal-regulating kinase 1 (ASK1) was activated in cells by the synthetic double-stranded RNA analog polyinosinic:polycytidylic acid [poly(I:C)] and by RNA viruses, and that ASK1 played an essential role in both the induction of the gene encoding IFN-beta (IFNB) and apoptotic cell death. Poly C 206-224 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 82-118 26243192-3 2015 We showed that the mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK) apoptosis signal-regulating kinase 1 (ASK1) was activated in cells by the synthetic double-stranded RNA analog polyinosinic:polycytidylic acid [poly(I:C)] and by RNA viruses, and that ASK1 played an essential role in both the induction of the gene encoding IFN-beta (IFNB) and apoptotic cell death. Poly C 206-224 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 120-124 26243192-3 2015 We showed that the mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK) apoptosis signal-regulating kinase 1 (ASK1) was activated in cells by the synthetic double-stranded RNA analog polyinosinic:polycytidylic acid [poly(I:C)] and by RNA viruses, and that ASK1 played an essential role in both the induction of the gene encoding IFN-beta (IFNB) and apoptotic cell death. Poly C 206-224 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 266-270 26243192-3 2015 We showed that the mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK) apoptosis signal-regulating kinase 1 (ASK1) was activated in cells by the synthetic double-stranded RNA analog polyinosinic:polycytidylic acid [poly(I:C)] and by RNA viruses, and that ASK1 played an essential role in both the induction of the gene encoding IFN-beta (IFNB) and apoptotic cell death. Poly C 206-224 interferon beta 1 Homo sapiens 339-347 26243192-3 2015 We showed that the mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK) apoptosis signal-regulating kinase 1 (ASK1) was activated in cells by the synthetic double-stranded RNA analog polyinosinic:polycytidylic acid [poly(I:C)] and by RNA viruses, and that ASK1 played an essential role in both the induction of the gene encoding IFN-beta (IFNB) and apoptotic cell death. Poly C 206-224 interferon beta 1 Homo sapiens 349-353 26125808-10 2015 Individuals challenged with infectious pancreatic necrosis virus and immunostimulated with polyinosinic:polycytidylic acid exhibited increased expression of TLR3 at the mRNA level, indicating that ssTLR3 may be involved in pathogen recognition in the early innate immune system. Poly C 104-122 toll-like receptor 3 Salmo salar 157-161 26125808-10 2015 Individuals challenged with infectious pancreatic necrosis virus and immunostimulated with polyinosinic:polycytidylic acid exhibited increased expression of TLR3 at the mRNA level, indicating that ssTLR3 may be involved in pathogen recognition in the early innate immune system. Poly C 104-122 toll-like receptor 3 Salmo salar 197-203 26261610-0 2015 Expression of poly(C)-binding protein 1 (PCBP1) in NSCLC as a negative regulator of EMT and its clinical value. Poly C 14-20 poly(rC) binding protein 1 Homo sapiens 41-46 26261610-1 2015 Poly (C)-binding Protein 1 (PCBP1) is a 35 kDa protein involved in a number of biological processes. Poly C 0-7 poly(rC) binding protein 1 Homo sapiens 28-33 25679777-4 2015 Immunization of BALB/c mice with the recombinant mAb in the presence of polyriboinosinic: polyribocytidylic acid (poly (I:C)) specifically enhanced the number of IFN-gamma producing cells and CD4+ T cell proliferation when compared to mice immunized with a mAb without receptor affinity or with the non-targeted ASP-2 protein. Poly C 90-112 CD4 antigen Mus musculus 192-195 25488424-7 2015 Interaction analysis of polyinosinic:polycytidylic acid (poly I:C) and dsRNA depicted leucine-rich-repeats (LRR)2-3 and LRR18-19 (in TLR3) and LRRNT-LRR3 and LRR22-24 (in TLR22) as the potential binding sites. Poly C 37-55 toll-like receptor 3 Danio rerio 133-137 25345551-5 2015 RESULTS: Although flow cytometry and IHC revealed HBCs to be M2 (anti-inflammatory) macrophages, LPS and polyinosinic: polycytidylic acid [poly (I:C)] treatments markedly enhanced IL-6 secretion by HBCs, and expression of TLR-2, TLR-3, TLR-4, CD14, and MD-2 was the highest in HBCs. Poly C 119-137 interleukin 6 Homo sapiens 180-184 26417991-2 2015 The aim of the study is to investigate the effect of polyriboinosinic:polyribocytidylic acid (poly(I:C)) in modulating toll-like receptor (TLR) 3-B-cell-activating factor belonging to the TNF family (BAFF) axis activation, which in turn promotes IgA CSR of IgAN patients and the IgAN rat model. Poly C 70-92 toll like receptor 3 Homo sapiens 139-142 26417991-2 2015 The aim of the study is to investigate the effect of polyriboinosinic:polyribocytidylic acid (poly(I:C)) in modulating toll-like receptor (TLR) 3-B-cell-activating factor belonging to the TNF family (BAFF) axis activation, which in turn promotes IgA CSR of IgAN patients and the IgAN rat model. Poly C 70-92 TNF superfamily member 13b Homo sapiens 200-204 26417991-2 2015 The aim of the study is to investigate the effect of polyriboinosinic:polyribocytidylic acid (poly(I:C)) in modulating toll-like receptor (TLR) 3-B-cell-activating factor belonging to the TNF family (BAFF) axis activation, which in turn promotes IgA CSR of IgAN patients and the IgAN rat model. Poly C 70-92 IGAN1 Homo sapiens 257-261 26417991-2 2015 The aim of the study is to investigate the effect of polyriboinosinic:polyribocytidylic acid (poly(I:C)) in modulating toll-like receptor (TLR) 3-B-cell-activating factor belonging to the TNF family (BAFF) axis activation, which in turn promotes IgA CSR of IgAN patients and the IgAN rat model. Poly C 70-92 IGAN1 Homo sapiens 279-283 25345551-5 2015 RESULTS: Although flow cytometry and IHC revealed HBCs to be M2 (anti-inflammatory) macrophages, LPS and polyinosinic: polycytidylic acid [poly (I:C)] treatments markedly enhanced IL-6 secretion by HBCs, and expression of TLR-2, TLR-3, TLR-4, CD14, and MD-2 was the highest in HBCs. Poly C 119-137 toll like receptor 2 Homo sapiens 222-227 25345551-5 2015 RESULTS: Although flow cytometry and IHC revealed HBCs to be M2 (anti-inflammatory) macrophages, LPS and polyinosinic: polycytidylic acid [poly (I:C)] treatments markedly enhanced IL-6 secretion by HBCs, and expression of TLR-2, TLR-3, TLR-4, CD14, and MD-2 was the highest in HBCs. Poly C 119-137 toll like receptor 3 Homo sapiens 229-234 25345551-5 2015 RESULTS: Although flow cytometry and IHC revealed HBCs to be M2 (anti-inflammatory) macrophages, LPS and polyinosinic: polycytidylic acid [poly (I:C)] treatments markedly enhanced IL-6 secretion by HBCs, and expression of TLR-2, TLR-3, TLR-4, CD14, and MD-2 was the highest in HBCs. Poly C 119-137 toll like receptor 4 Homo sapiens 236-241 25345551-5 2015 RESULTS: Although flow cytometry and IHC revealed HBCs to be M2 (anti-inflammatory) macrophages, LPS and polyinosinic: polycytidylic acid [poly (I:C)] treatments markedly enhanced IL-6 secretion by HBCs, and expression of TLR-2, TLR-3, TLR-4, CD14, and MD-2 was the highest in HBCs. Poly C 119-137 CD14 molecule Homo sapiens 243-247 25287058-5 2014 Using RNase L-deficient, rat insulin promoter-B7.1 transgenic mice, which are more vulnerable to harmful environmental factors such as viral infection, we demonstrated that deficiency of RNase L in mice resulted in a significant delay of diabetes onset induced by polyinosinic:polycytidylic acid (poly I:C), a type of synthetic dsRNA, and streptozotocin, a drug which can artificially induce type 1-like diabetes in experimental animals. Poly C 277-295 ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) Mus musculus 187-194 25449705-9 2015 In in vitro experiments performed in coelomocytes, the expression of StmGILT mRNA was significantly up-regulated by lipopolysaccharides (LPS), inactivated bacteria or polyriboinosinic polyribocytidylic acid [poly (I:C)] challenge, suggested that the sea cucumber GILT might play critical roles in the innate immune defending against bacterial and viral infections. Poly C 184-206 gamma-interferon-responsive lysosomal thiol protein Cucumis sativus 72-76 25918711-5 2015 Luciferase reporter assay and enzyme-linked immunosorbent assay (ELISA) detected the duRIG-I significantly activated NF-kappaB and induced the expression of IFN-beta when polyinosinic-polycytidylic acid (poly[I:C], synthetic double-stranded RNA) challenges chicken embryonic fibroblasts cells (DF1 cells), while the duRIG-I was inactive in the absence of poly[I:C]. Poly C 183-202 interferon omega 1 Gallus gallus 157-165 25014275-4 2014 Interestingly, the TLR3 agonist polyinosinic:polycytidylic acid (poly(I:C)) mediated phosphorylation of NF-kappaB and extracellular stress-related kinase 1/2 (ERK1/2), which significantly decreased following PGE2 treatment. Poly C 45-63 toll like receptor 3 Homo sapiens 19-23 25014275-4 2014 Interestingly, the TLR3 agonist polyinosinic:polycytidylic acid (poly(I:C)) mediated phosphorylation of NF-kappaB and extracellular stress-related kinase 1/2 (ERK1/2), which significantly decreased following PGE2 treatment. Poly C 45-63 mitogen-activated protein kinase 3 Homo sapiens 159-165 24843120-2 2014 Poly(rC)-binding proteins PCBP1 and PCBP2 are multifunctional adaptor proteins that bind iron and deliver it to ferritin for storage or to prolyl and asparagyl hydroxylases to metallate the mononuclear iron center. Poly C 0-8 poly(rC) binding protein 2 Homo sapiens 36-41 24958903-4 2014 Zebrafish IRF10 (DrIRF10) was induced by intracellular polyinosinic:polycytidylic acid in ZF4 (zebrafish embryo fibroblast-like) cells. Poly C 68-86 interferon regulatory factor 10 Danio rerio 10-15 24958903-4 2014 Zebrafish IRF10 (DrIRF10) was induced by intracellular polyinosinic:polycytidylic acid in ZF4 (zebrafish embryo fibroblast-like) cells. Poly C 68-86 interferon regulatory factor 10 Danio rerio 17-24 24958903-5 2014 DrIRF10 inhibited the activation of zebrafish IFN1 (DrIFN1) and DrIFN3 promoters in epithelioma papulosum cyprinid cells in the presence or absence of polyinosinic:polycytidylic acid stimulation through direct interaction with the IFN promoters, and this inhibition was also shown to block IFN signaling. Poly C 164-182 interferon regulatory factor 10 Danio rerio 0-7 25200153-3 2014 Twenty-four hours later, real-time quantitative PCR was applied to detect the dynamic change of IFN-beta and Mx1 mRNA expressions under the stimulation of polyinosinic polycytidylic acid (PolyI:C). Poly C 188-195 interferon omega 1 Gallus gallus 96-104 25200153-3 2014 Twenty-four hours later, real-time quantitative PCR was applied to detect the dynamic change of IFN-beta and Mx1 mRNA expressions under the stimulation of polyinosinic polycytidylic acid (PolyI:C). Poly C 188-195 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) Gallus gallus 109-112 25200153-5 2014 The expression levels of IFN-beta and Mx1 gene in cells transfected with pEGFP-C1-ALB were significantly lower than those transfected with pEGFP-C1 after 12-hour stimulation of PolyI:C (P<0.05 or P<0.01). Poly C 177-184 interferon omega 1 Gallus gallus 25-33 25200153-5 2014 The expression levels of IFN-beta and Mx1 gene in cells transfected with pEGFP-C1-ALB were significantly lower than those transfected with pEGFP-C1 after 12-hour stimulation of PolyI:C (P<0.05 or P<0.01). Poly C 177-184 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) Gallus gallus 38-41 25200153-5 2014 The expression levels of IFN-beta and Mx1 gene in cells transfected with pEGFP-C1-ALB were significantly lower than those transfected with pEGFP-C1 after 12-hour stimulation of PolyI:C (P<0.05 or P<0.01). Poly C 177-184 albumin Gallus gallus 82-85 24113362-6 2014 The expression of interferon (IFN)-beta was induced by the addition of polyinosinic:polycytidylic acid [poly(I:C)] in TS cells, but not ES cells, although TLR-3 was expressed at the same level in both cell types. Poly C 84-102 interferon beta 1, fibroblast Mus musculus 18-39 24843120-2 2014 Poly(rC)-binding proteins PCBP1 and PCBP2 are multifunctional adaptor proteins that bind iron and deliver it to ferritin for storage or to prolyl and asparagyl hydroxylases to metallate the mononuclear iron center. Poly C 0-8 poly(rC) binding protein 1 Homo sapiens 26-31 24706959-0 2014 Dramatic differences in the response of macrophages from B2 and B19 MHC-defined haplotypes to interferon gamma and polyinosinic:polycytidylic acid stimulation. Poly C 128-146 immunoglobulin kappa variable 5-2 Homo sapiens 57-65 24447537-8 2014 Mechanistic studies show that PELP1 binds RNA with a preference to poly-C, co-localizes with the splicing factor SC35 at nuclear speckles, and participates in alternative splicing. Poly C 67-73 proline, glutamate and leucine rich protein 1 Homo sapiens 30-35 24035358-5 2013 It was found that microRNA-301a (miR-301a) was up-regulated by the ligands of TLR3 and TLR4, LPS and polyinosinic acid:polycytidylic acid poly(I:C). Poly C 119-137 microRNA 301a Homo sapiens 18-31 24056124-5 2013 Tunicamycin also inhibited the expression of inflammatory molecule mRNAs induced by stimulation of TLR2 (with lipoteichoic acid) or TLR3 (with polyinosinic:polycytidylic acid), which do not require myeloid differentiation protein-2 (MD2) for their activation. Poly C 156-174 toll-like receptor 3 Mus musculus 132-136 24035358-5 2013 It was found that microRNA-301a (miR-301a) was up-regulated by the ligands of TLR3 and TLR4, LPS and polyinosinic acid:polycytidylic acid poly(I:C). Poly C 119-137 microRNA 301a Homo sapiens 33-41 24035358-5 2013 It was found that microRNA-301a (miR-301a) was up-regulated by the ligands of TLR3 and TLR4, LPS and polyinosinic acid:polycytidylic acid poly(I:C). Poly C 119-137 toll like receptor 3 Homo sapiens 78-82 24035358-5 2013 It was found that microRNA-301a (miR-301a) was up-regulated by the ligands of TLR3 and TLR4, LPS and polyinosinic acid:polycytidylic acid poly(I:C). Poly C 119-137 toll like receptor 4 Homo sapiens 87-91 23871888-10 2013 Treatment with CVB3 and polyinosinic:polycytidylic acid led to higher IFNbeta expression in PAR2ko than in wt fibroblasts and reduced virus replication in PAR2ko fibroblasts was abrogated by neutralizing IFNbeta antibody. Poly C 37-55 interferon beta 1 Homo sapiens 70-77 24056979-6 2013 However, TLR3 and interferon signaling pathways were decreased to a greater extent, and assessment of the effects of SMD on polyinosinic polycytidylic acid-induced cytokine and chemokine production revealed that these responses mediated by TLR3 were indeed sensitive to the effects of SMD, with inhibition occurring at lower dosages than required to inhibit responses to other immunological stimuli tested in our previous studies. Poly C 137-155 toll-like receptor 3 Mus musculus 240-244 23871888-10 2013 Treatment with CVB3 and polyinosinic:polycytidylic acid led to higher IFNbeta expression in PAR2ko than in wt fibroblasts and reduced virus replication in PAR2ko fibroblasts was abrogated by neutralizing IFNbeta antibody. Poly C 37-55 interferon beta 1 Homo sapiens 204-211 23887873-5 2013 Tlr4(-/-) mice primed with TLR3 agonist polyinosinic:polycytidylic acid [poly(I:C)] to induce pro-caspase-11 expression were as susceptible as wild-type mice were to sepsis induced by E. coli LPS. Poly C 53-71 toll-like receptor 4 Mus musculus 0-4 24026233-0 2013 Novel function of the poly(c)-binding protein alpha-CP2 as a transcriptional activator that binds to single-stranded DNA sequences. Poly C 22-28 poly(rC) binding protein 2 Mus musculus 46-55 24026233-1 2013 alpha-complex protein 2 (alpha-CP2) is known as an RNA-binding protein that interacts in a sequence-specific manner with single-stranded polycytosine [poly(C)]. Poly C 151-158 poly(rC) binding protein 2 Mus musculus 0-23 24026233-1 2013 alpha-complex protein 2 (alpha-CP2) is known as an RNA-binding protein that interacts in a sequence-specific manner with single-stranded polycytosine [poly(C)]. Poly C 151-158 poly(rC) binding protein 2 Mus musculus 25-34 24026233-8 2013 Furthermore, plasmids expressing alpha-CP2 activated the expression of a luciferase reporter when co-transfected with a single-stranded (pGL-SS) construct containing a poly(C) sequence. Poly C 168-175 poly(rC) binding protein 2 Mus musculus 33-42 24026233-9 2013 To our knowledge, this study demonstrates for the first time that alpha-CP2 functions as a transcriptional activator by binding to a single-stranded poly(C) sequence. Poly C 149-156 poly(rC) binding protein 2 Mus musculus 66-75 23887873-5 2013 Tlr4(-/-) mice primed with TLR3 agonist polyinosinic:polycytidylic acid [poly(I:C)] to induce pro-caspase-11 expression were as susceptible as wild-type mice were to sepsis induced by E. coli LPS. Poly C 53-71 toll-like receptor 3 Mus musculus 27-31 23541683-3 2013 Activation of TLR3 by polyinosinic:polycytidylic acid [poly(I:C)] treatment is effective to suppress cell migration and invasion and to decrease organized assembly of F-actin and filopodia formation, in TLR3-expressing SK-N-AS cells, which could be reversed by TLR3-targeting siRNA treatment. Poly C 35-53 toll like receptor 3 Homo sapiens 14-18 23742880-7 2013 Furthermore, the polypeptide micelles could simultaneously encapsulate OVA and polyriboinosinic: polyribocytidylic acid (PIC), a TLR3 agonist, to synergistically augment tumor specific cytotoxic-T-lymphocyte (CTL) response. Poly C 97-119 toll like receptor 3 Homo sapiens 129-133 23742880-7 2013 Furthermore, the polypeptide micelles could simultaneously encapsulate OVA and polyriboinosinic: polyribocytidylic acid (PIC), a TLR3 agonist, to synergistically augment tumor specific cytotoxic-T-lymphocyte (CTL) response. Poly C 121-124 toll like receptor 3 Homo sapiens 129-133 23541683-3 2013 Activation of TLR3 by polyinosinic:polycytidylic acid [poly(I:C)] treatment is effective to suppress cell migration and invasion and to decrease organized assembly of F-actin and filopodia formation, in TLR3-expressing SK-N-AS cells, which could be reversed by TLR3-targeting siRNA treatment. Poly C 35-53 toll like receptor 3 Homo sapiens 203-207 23541683-3 2013 Activation of TLR3 by polyinosinic:polycytidylic acid [poly(I:C)] treatment is effective to suppress cell migration and invasion and to decrease organized assembly of F-actin and filopodia formation, in TLR3-expressing SK-N-AS cells, which could be reversed by TLR3-targeting siRNA treatment. Poly C 35-53 toll like receptor 3 Homo sapiens 203-207 23941132-9 2013 In NHBE cells, mRNA expression of CEACAM1 isoforms CEACAM1-4L, CEACAM1-4S, CEACAM1-3L and CEACAM1-3S were up-regulated by interferons alpha, beta and gamma, as well as the TLR3 agonist polyinosinic:polycytidylic acid (poly I:C). Poly C 198-216 CEA cell adhesion molecule 1 Homo sapiens 34-41 23941132-9 2013 In NHBE cells, mRNA expression of CEACAM1 isoforms CEACAM1-4L, CEACAM1-4S, CEACAM1-3L and CEACAM1-3S were up-regulated by interferons alpha, beta and gamma, as well as the TLR3 agonist polyinosinic:polycytidylic acid (poly I:C). Poly C 198-216 CEA cell adhesion molecule 1 Homo sapiens 51-58 23941132-9 2013 In NHBE cells, mRNA expression of CEACAM1 isoforms CEACAM1-4L, CEACAM1-4S, CEACAM1-3L and CEACAM1-3S were up-regulated by interferons alpha, beta and gamma, as well as the TLR3 agonist polyinosinic:polycytidylic acid (poly I:C). Poly C 198-216 CEA cell adhesion molecule 1 Homo sapiens 51-58 23941132-9 2013 In NHBE cells, mRNA expression of CEACAM1 isoforms CEACAM1-4L, CEACAM1-4S, CEACAM1-3L and CEACAM1-3S were up-regulated by interferons alpha, beta and gamma, as well as the TLR3 agonist polyinosinic:polycytidylic acid (poly I:C). Poly C 198-216 CEA cell adhesion molecule 1 Homo sapiens 51-58 23941132-9 2013 In NHBE cells, mRNA expression of CEACAM1 isoforms CEACAM1-4L, CEACAM1-4S, CEACAM1-3L and CEACAM1-3S were up-regulated by interferons alpha, beta and gamma, as well as the TLR3 agonist polyinosinic:polycytidylic acid (poly I:C). Poly C 198-216 CEA cell adhesion molecule 1 Homo sapiens 51-58 23739343-7 2013 A Toll-like receptor (TLR)3 agonist and viral mimetic polyinosinic:polycytidylic acid evoked a robust fever in CB1(-/-) mice, suggesting TLR3-mediated responses are functional. Poly C 67-85 cannabinoid receptor 1 (brain) Mus musculus 111-114 23739343-7 2013 A Toll-like receptor (TLR)3 agonist and viral mimetic polyinosinic:polycytidylic acid evoked a robust fever in CB1(-/-) mice, suggesting TLR3-mediated responses are functional. Poly C 67-85 toll-like receptor 3 Mus musculus 137-141 23586396-10 2013 This was accompanied by a parallel reduction in the poly I:C-stimulated elevation in plasma levels of IL-1beta and PGE2. Poly C 52-60 interleukin-1 beta Oryctolagus cuniculus 102-110 23720812-5 2013 Treatment with LPS preferentially stimulated IL-17 production, whereas CpG oligodeoxynucleotide and polyinosinic:polycytidylic acid primarily stimulated Th1 cells. Poly C 113-131 negative elongation factor complex member C/D, Th1l Mus musculus 153-156 23677472-7 2013 Moreover, although both Wnts suppress proinflammatory responses to bacterial endotoxin and to TLR1/2, TLR7, and TLR9 ligands, Wnt5A, but not Wnt3A, inhibits IL-6 production in response to the viral mimic, polyinosinic:polycytidylic acid. Poly C 218-236 wingless-type MMTV integration site family, member 5A Mus musculus 126-131 23716670-3 2013 Here we show that TLR3 activation by polyinosinic:polycytidylic acid induces up-regulation of microRNA-29b, -29c, -148b, and -152 in tumor-derived cell lines and primary tumors. Poly C 50-68 toll like receptor 3 Homo sapiens 18-22 23716670-5 2013 In DU145 and TRAMP-C1 prostate and MDA-MB-231 breast cancer cells, we demonstrated that polyinosinic:polycytidylic acid-mediated activation of TLR3 induces microRNAs targeting DNA methyltransferases, leading to demethylation and reexpression of the oncosuppressor retinoic acid receptor beta (RARbeta). Poly C 101-119 toll like receptor 3 Homo sapiens 143-147 23716670-5 2013 In DU145 and TRAMP-C1 prostate and MDA-MB-231 breast cancer cells, we demonstrated that polyinosinic:polycytidylic acid-mediated activation of TLR3 induces microRNAs targeting DNA methyltransferases, leading to demethylation and reexpression of the oncosuppressor retinoic acid receptor beta (RARbeta). Poly C 101-119 retinoic acid receptor beta Homo sapiens 264-291 23716670-5 2013 In DU145 and TRAMP-C1 prostate and MDA-MB-231 breast cancer cells, we demonstrated that polyinosinic:polycytidylic acid-mediated activation of TLR3 induces microRNAs targeting DNA methyltransferases, leading to demethylation and reexpression of the oncosuppressor retinoic acid receptor beta (RARbeta). Poly C 101-119 retinoic acid receptor beta Homo sapiens 293-300 22951310-2 2012 In the present study, we have analyzed the interaction of Nsp1beta of Chinese highly pathogenic PRRSV (HP-PRRSV) with cellular poly(C)-binding 2 (PCBP2) by means of the yeast two-hybrid screening in a pulmonary alveolar macrophages (PAMs) cDNA library and co-immunoprecipitation (Co-IP) assay. Poly C 127-134 poly(rC) binding protein 2 Homo sapiens 146-151 23387336-4 2013 METHODS: TLR3 activation via polyinosinic acid/polycytidylic acid (Poly I:C) was investigated in primary porcine RPE cells, focussing on cell death and vascular endothelial growth factor (VEGF) secretion. Poly C 47-65 toll like receptor 3 Homo sapiens 9-13 23673618-6 2013 Like polyriboinosinic:polyribocytidylic acid, a synthetic double-stranded RNA, these RNAs are internalized into cells via raftlin-mediated endocytosis and colocalized with TLR3. Poly C 22-44 raftlin, lipid raft linker 1 Homo sapiens 122-129 23673618-6 2013 Like polyriboinosinic:polyribocytidylic acid, a synthetic double-stranded RNA, these RNAs are internalized into cells via raftlin-mediated endocytosis and colocalized with TLR3. Poly C 22-44 toll like receptor 3 Homo sapiens 172-176 23087404-3 2012 We found that overexpression of Ndfip1 severely impaired MAVS and Sendai virus-mediated activation of IFN-stimulated response element, NF-kappaB, IFN-beta promoter, and polyinosinic-polycytidylic acid or influenza virus RNA-stimulated IRF-3 phosphorylation, as well as the transcription of IFN-beta. Poly C 181-200 Nedd4 family interacting protein 1 Homo sapiens 32-38 23585479-1 2013 PCBP2 is a member of the poly(C)-binding protein (PCBP) family, which plays an important role in posttranscriptional and translational regulation by interacting with single-stranded poly(C) motifs in target mRNAs. Poly C 25-32 poly(rC) binding protein 2 Homo sapiens 0-5 23153456-7 2013 Using the viral mimic polyinosinic:polycytidylic acid and the IFNalpha/beta antagonist B18R we furthermore demonstrate the capability of endogenous IFN to promote IL-22-induced STAT1 activation and expression of CXCL10. Poly C 35-53 interleukin 22 Homo sapiens 163-168 23153456-7 2013 Using the viral mimic polyinosinic:polycytidylic acid and the IFNalpha/beta antagonist B18R we furthermore demonstrate the capability of endogenous IFN to promote IL-22-induced STAT1 activation and expression of CXCL10. Poly C 35-53 signal transducer and activator of transcription 1 Homo sapiens 177-182 23153456-7 2013 Using the viral mimic polyinosinic:polycytidylic acid and the IFNalpha/beta antagonist B18R we furthermore demonstrate the capability of endogenous IFN to promote IL-22-induced STAT1 activation and expression of CXCL10. Poly C 35-53 C-X-C motif chemokine ligand 10 Homo sapiens 212-218 23178261-10 2013 TGF-beta1b expression was also increased by polyinosinic:polycytidylic acid (poly(I:C)) and/or lipopolysaccharide (LPS) stimulation in three different trout cell lines studied. Poly C 57-75 transforming growth factor, beta 1a Oncorhynchus mykiss 0-10 22732733-6 2013 The TfPLL conjugate protected TLR3 ligand polyinosinic:polycytidylic acid [poly(I:C)] from RNase degradation and enhanced the uptake of poly(I:C) in HeLa cells. Poly C 55-73 toll like receptor 3 Homo sapiens 30-34 22914602-4 2012 OBJECTIVE: To study the effects and signaling pathways of formoterol and salmeterol on polyriboinosinic polyribocytidylic acid (poly I:C)-induced IP-10 expression in BEAS-2B cells. Poly C 128-136 C-X-C motif chemokine ligand 10 Homo sapiens 146-151 22797253-2 2012 All-trans retinoic acid (ATRA) and polyinosinic:polycytidylic acid (polyI:C) are strong inducers of toll-like receptor 3 (TLR3) and MDA5 expression, and polyI:C-induced TLR3 and MDA5 signaling specifically causes cell death in melanoma cells in vitro. Poly C 48-66 toll like receptor 3 Homo sapiens 100-120 22797253-2 2012 All-trans retinoic acid (ATRA) and polyinosinic:polycytidylic acid (polyI:C) are strong inducers of toll-like receptor 3 (TLR3) and MDA5 expression, and polyI:C-induced TLR3 and MDA5 signaling specifically causes cell death in melanoma cells in vitro. Poly C 48-66 toll like receptor 3 Homo sapiens 122-126 22797253-2 2012 All-trans retinoic acid (ATRA) and polyinosinic:polycytidylic acid (polyI:C) are strong inducers of toll-like receptor 3 (TLR3) and MDA5 expression, and polyI:C-induced TLR3 and MDA5 signaling specifically causes cell death in melanoma cells in vitro. Poly C 48-66 interferon induced with helicase C domain 1 Homo sapiens 132-136 22797253-2 2012 All-trans retinoic acid (ATRA) and polyinosinic:polycytidylic acid (polyI:C) are strong inducers of toll-like receptor 3 (TLR3) and MDA5 expression, and polyI:C-induced TLR3 and MDA5 signaling specifically causes cell death in melanoma cells in vitro. Poly C 48-66 toll like receptor 3 Homo sapiens 169-173 22797253-2 2012 All-trans retinoic acid (ATRA) and polyinosinic:polycytidylic acid (polyI:C) are strong inducers of toll-like receptor 3 (TLR3) and MDA5 expression, and polyI:C-induced TLR3 and MDA5 signaling specifically causes cell death in melanoma cells in vitro. Poly C 48-66 interferon induced with helicase C domain 1 Homo sapiens 178-182 22681877-3 2012 Pregnant rats were treated with the double-stranded RNA polyinosinic:polycytidylic acid (poly(I:C); 10 mg/kg) which mimics immune activation occurring after activation of Toll-like receptors-3 (TLR3) by viral infection. Poly C 69-87 toll-like receptor 3 Rattus norvegicus 171-192 22698190-1 2012 BACKGROUND: Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid: polycytidylic acid [Poly (I:C)], are recognized by toll-like receptor 3 (TLR3) and induce interferon (IFN)-beta in many cell types. Poly C 74-92 toll like receptor 3 Homo sapiens 125-145 22698190-1 2012 BACKGROUND: Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid: polycytidylic acid [Poly (I:C)], are recognized by toll-like receptor 3 (TLR3) and induce interferon (IFN)-beta in many cell types. Poly C 74-92 toll like receptor 3 Homo sapiens 147-151 22698190-1 2012 BACKGROUND: Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid: polycytidylic acid [Poly (I:C)], are recognized by toll-like receptor 3 (TLR3) and induce interferon (IFN)-beta in many cell types. Poly C 74-92 interferon beta 1 Homo sapiens 164-185 22521865-6 2012 Electrophoretic mobility shift assays demonstrated that the recombinant PCBP3 is capable of binding to both double- and single-strand poly(C) sequences. Poly C 134-141 poly(rC) binding protein 3 Homo sapiens 72-77 22521865-7 2012 Furthermore, plasmids expressing PCBP3 repressed the expression of luciferase reporters when cotransfected with single-strand (pGL-SS) and double-strand (pGL-DS) constructs containing poly(C) sequences in their promoters. Poly C 184-191 poly(rC) binding protein 3 Homo sapiens 33-38 22521865-8 2012 This study demonstrates for the first time that PCBP3 can function as a repressor dependent on binding to single-strand and double-stranded poly(C) sequences. Poly C 140-147 poly(rC) binding protein 3 Homo sapiens 48-53 22634298-3 2012 Although polyriboinosinic: polyribocytidylic acid (PIC), a TLR3 agonist, has been reported as a promising adjuvant for cancer vaccines, its immunopotency may be limited by insufficient cellular penetration. Poly C 51-54 toll-like receptor 3 Mus musculus 59-63 22634298-9 2012 Taking together, the complex of PIC and DOTAP liposomes enhanced PIC uptake and consequential TLR3 signaling in BMDCs, which in turn promoted DC maturation and type I IFN production, thereby augmenting the antitumor effect of cancer vaccines. Poly C 32-35 toll-like receptor 3 Mus musculus 94-98 22466005-3 2012 Based on this knowledge, this study aimed to define the effects of the TLR3 ligand polyriboinosinic:polyribocytidylic acid (poly(I:C)) on the expression of adhesion molecules and macrophage colony-stimulating factor (M-CSF) on resident glomerular cells. Poly C 100-122 toll like receptor 3 Homo sapiens 71-75 22466005-3 2012 Based on this knowledge, this study aimed to define the effects of the TLR3 ligand polyriboinosinic:polyribocytidylic acid (poly(I:C)) on the expression of adhesion molecules and macrophage colony-stimulating factor (M-CSF) on resident glomerular cells. Poly C 100-122 colony stimulating factor 1 Homo sapiens 179-215 22466005-3 2012 Based on this knowledge, this study aimed to define the effects of the TLR3 ligand polyriboinosinic:polyribocytidylic acid (poly(I:C)) on the expression of adhesion molecules and macrophage colony-stimulating factor (M-CSF) on resident glomerular cells. Poly C 100-122 colony stimulating factor 1 Homo sapiens 217-222 22681877-3 2012 Pregnant rats were treated with the double-stranded RNA polyinosinic:polycytidylic acid (poly(I:C); 10 mg/kg) which mimics immune activation occurring after activation of Toll-like receptors-3 (TLR3) by viral infection. Poly C 69-87 toll-like receptor 3 Rattus norvegicus 194-198 22497726-6 2012 Activation of TLR4 and TLR3 signaling through LPS and polyinosinic:polycytidylic acid [poly(I:C)] treatments resulted in rapid down-regulation of HFE protein [encoded by the hemochromatosis gene (Hfe)] and ferroportin [encoded by solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1)] expression in the spleen, independent of MyD88 or TRIF signaling and proinflammatory cytokine production. Poly C 67-85 toll-like receptor 4 Mus musculus 14-18 22497726-6 2012 Activation of TLR4 and TLR3 signaling through LPS and polyinosinic:polycytidylic acid [poly(I:C)] treatments resulted in rapid down-regulation of HFE protein [encoded by the hemochromatosis gene (Hfe)] and ferroportin [encoded by solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1)] expression in the spleen, independent of MyD88 or TRIF signaling and proinflammatory cytokine production. Poly C 67-85 toll-like receptor 3 Mus musculus 23-27 22497726-6 2012 Activation of TLR4 and TLR3 signaling through LPS and polyinosinic:polycytidylic acid [poly(I:C)] treatments resulted in rapid down-regulation of HFE protein [encoded by the hemochromatosis gene (Hfe)] and ferroportin [encoded by solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1)] expression in the spleen, independent of MyD88 or TRIF signaling and proinflammatory cytokine production. Poly C 67-85 homeostatic iron regulator Mus musculus 146-149 22497726-6 2012 Activation of TLR4 and TLR3 signaling through LPS and polyinosinic:polycytidylic acid [poly(I:C)] treatments resulted in rapid down-regulation of HFE protein [encoded by the hemochromatosis gene (Hfe)] and ferroportin [encoded by solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1)] expression in the spleen, independent of MyD88 or TRIF signaling and proinflammatory cytokine production. Poly C 67-85 homeostatic iron regulator Mus musculus 196-199 22497726-6 2012 Activation of TLR4 and TLR3 signaling through LPS and polyinosinic:polycytidylic acid [poly(I:C)] treatments resulted in rapid down-regulation of HFE protein [encoded by the hemochromatosis gene (Hfe)] and ferroportin [encoded by solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1)] expression in the spleen, independent of MyD88 or TRIF signaling and proinflammatory cytokine production. Poly C 67-85 solute carrier family 40 (iron-regulated transporter), member 1 Mus musculus 295-302 22497726-6 2012 Activation of TLR4 and TLR3 signaling through LPS and polyinosinic:polycytidylic acid [poly(I:C)] treatments resulted in rapid down-regulation of HFE protein [encoded by the hemochromatosis gene (Hfe)] and ferroportin [encoded by solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1)] expression in the spleen, independent of MyD88 or TRIF signaling and proinflammatory cytokine production. Poly C 67-85 myeloid differentiation primary response gene 88 Mus musculus 346-351 21799119-3 2012 We recently showed that a low-dose administration of polyinosinic polycytidylic acid (poly IC), a mimetic of viral dsRNA, during allergen sensitization augments airway eosinophilia and hyperresponsiveness in mice via enhanced production of IL-13 from T cells. Poly C 86-93 interleukin 13 Mus musculus 240-245 22497726-6 2012 Activation of TLR4 and TLR3 signaling through LPS and polyinosinic:polycytidylic acid [poly(I:C)] treatments resulted in rapid down-regulation of HFE protein [encoded by the hemochromatosis gene (Hfe)] and ferroportin [encoded by solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1)] expression in the spleen, independent of MyD88 or TRIF signaling and proinflammatory cytokine production. Poly C 67-85 toll-like receptor adaptor molecule 2 Mus musculus 355-359 21799119-9 2012 Serum IL-6 was prominently higher in the mice treated with poly IC/d-GalN than in that with poly IC alone or d-GalN alone. Poly C 59-66 interleukin 6 Mus musculus 6-10 22503273-3 2012 This study found that purified DSC extensively shed BAFF-R and that polyinosinic:polycytidylic acid (poly(I:C); a synthetic toll-like receptor (TLR) 3 agonist) dramatically up-regulated BAFF-R secretion, suggesting that release of these soluble proteins was an inherent property of DSC and its induction might have relevance to TLR-3-mediated signal transduction. Poly C 81-99 toll like receptor 3 Homo sapiens 144-147 21799119-9 2012 Serum IL-6 was prominently higher in the mice treated with poly IC/d-GalN than in that with poly IC alone or d-GalN alone. Poly C 59-66 galanin and GMAP prepropeptide Mus musculus 69-73 21799119-9 2012 Serum IL-6 was prominently higher in the mice treated with poly IC/d-GalN than in that with poly IC alone or d-GalN alone. Poly C 59-66 galanin and GMAP prepropeptide Mus musculus 111-115 22503273-3 2012 This study found that purified DSC extensively shed BAFF-R and that polyinosinic:polycytidylic acid (poly(I:C); a synthetic toll-like receptor (TLR) 3 agonist) dramatically up-regulated BAFF-R secretion, suggesting that release of these soluble proteins was an inherent property of DSC and its induction might have relevance to TLR-3-mediated signal transduction. Poly C 81-99 TNF receptor superfamily member 13C Homo sapiens 186-192 22503273-3 2012 This study found that purified DSC extensively shed BAFF-R and that polyinosinic:polycytidylic acid (poly(I:C); a synthetic toll-like receptor (TLR) 3 agonist) dramatically up-regulated BAFF-R secretion, suggesting that release of these soluble proteins was an inherent property of DSC and its induction might have relevance to TLR-3-mediated signal transduction. Poly C 81-99 toll like receptor 3 Homo sapiens 328-333 22315398-0 2012 Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells. Poly C 92-110 protein phosphatase 1 regulatory subunit 15A Homo sapiens 30-38 22198151-0 2012 A synthetic double-stranded RNA, poly I:C, induces a rapid apoptosis of human CD34(+) cells. Poly C 33-41 CD34 molecule Homo sapiens 78-82 22198151-4 2012 Here we show that polyinosinic polycytidylic acid (poly I:C)-mediated very rapid apoptosis occurs within 1 hour in CD34(+) cells in a dose-dependent manner. Poly C 51-59 CD34 molecule Homo sapiens 115-119 22198151-6 2012 Poly I:C-LMW/LyoVec, a complex between low molecular-weight poly I:C and the transfection reagent LyoVec, which signals only through RIG-I/MDA-5, induces apoptosis of CD34(+) cells. Poly C 60-68 DExD/H-box helicase 58 Homo sapiens 133-138 22198151-6 2012 Poly I:C-LMW/LyoVec, a complex between low molecular-weight poly I:C and the transfection reagent LyoVec, which signals only through RIG-I/MDA-5, induces apoptosis of CD34(+) cells. Poly C 60-68 interferon induced with helicase C domain 1 Homo sapiens 139-144 22198151-6 2012 Poly I:C-LMW/LyoVec, a complex between low molecular-weight poly I:C and the transfection reagent LyoVec, which signals only through RIG-I/MDA-5, induces apoptosis of CD34(+) cells. Poly C 60-68 CD34 molecule Homo sapiens 167-171 22198151-8 2012 These results suggest that RIG-I/MDA-5, but not TLR3, signaling triggers poly I:C-induced rapid apoptosis of human CD34(+) cells, which will provide an insight into the mechanisms of dsRNA virus-mediated hematopoietic disorders. Poly C 73-81 DExD/H-box helicase 58 Homo sapiens 27-32 22198151-8 2012 These results suggest that RIG-I/MDA-5, but not TLR3, signaling triggers poly I:C-induced rapid apoptosis of human CD34(+) cells, which will provide an insight into the mechanisms of dsRNA virus-mediated hematopoietic disorders. Poly C 73-81 interferon induced with helicase C domain 1 Homo sapiens 33-38 22198151-8 2012 These results suggest that RIG-I/MDA-5, but not TLR3, signaling triggers poly I:C-induced rapid apoptosis of human CD34(+) cells, which will provide an insight into the mechanisms of dsRNA virus-mediated hematopoietic disorders. Poly C 73-81 CD34 molecule Homo sapiens 115-119 22315398-0 2012 Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells. Poly C 92-110 protein phosphatase 1 regulatory subunit 15A Homo sapiens 39-45 22315398-2 2012 Here we show that in response to polyriboinosinic:polyribocytidylic acid (pI:C), DCs mount a specific integrated stress response during which the transcription factor ATF4 and the growth arrest and DNA damage-inducible protein 34 (GADD34/Ppp1r15a), a phosphatase 1 (PP1) cofactor, are expressed. Poly C 50-72 activating transcription factor 4 Homo sapiens 167-171 22315398-2 2012 Here we show that in response to polyriboinosinic:polyribocytidylic acid (pI:C), DCs mount a specific integrated stress response during which the transcription factor ATF4 and the growth arrest and DNA damage-inducible protein 34 (GADD34/Ppp1r15a), a phosphatase 1 (PP1) cofactor, are expressed. Poly C 50-72 protein phosphatase 1 regulatory subunit 15A Homo sapiens 231-237 22315398-2 2012 Here we show that in response to polyriboinosinic:polyribocytidylic acid (pI:C), DCs mount a specific integrated stress response during which the transcription factor ATF4 and the growth arrest and DNA damage-inducible protein 34 (GADD34/Ppp1r15a), a phosphatase 1 (PP1) cofactor, are expressed. Poly C 50-72 protein phosphatase 1 regulatory subunit 15A Homo sapiens 238-246 22496660-4 2012 Recombinant NS5 proteins of West Nile virus and Dengue virus (serotype 4; DENV-4) specifically methylates polyA, but not polyG, polyC, or polyU, indicating that the methylation occurs at adenosine residue. Poly C 128-133 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 12-15 21778412-5 2012 The potential consequences of diminished type I IFN signaling were demonstrated in a murine model of P. aeruginosa pneumonia, pretreatment with polyinosinic:polycytidylic acid significantly enhanced bacterial clearance and correlated with increased numbers of mature CD11c(+)/CD86(+) dendritic cells (DCs) in the lung. Poly C 157-175 integrin subunit alpha X Homo sapiens 267-272 21968540-0 2012 Interferon-beta, but not tumor necrosis factor-alpha, production in response to poly I:C is maintained despite exhaustive exercise in mice. Poly C 80-88 interferon beta 1, fibroblast Mus musculus 0-15 21968540-4 2012 Although TNF-alpha in response to poly I:C was significantly inhibited by exhaustive exercise, IFN-beta was no different in both groups. Poly C 34-42 tumor necrosis factor Mus musculus 9-18 21968540-5 2012 In in-vitro experiments, catecholamines inhibited poly I:C-induced TNF-alpha, but not IFN-beta, production in macrophages. Poly C 50-58 tumor necrosis factor Mus musculus 67-76 21968540-6 2012 These results suggest that anti-virus cytokine IFN-beta in response to poly I:C might be maintained despite severe stressful exercise. Poly C 71-79 interferon beta 1, fibroblast Mus musculus 47-55 21929369-4 2012 The TLR7 ligand poly-C inhibited low-path influenza A growth in the chicken macrophage cell line HD-11 more effectively than poly(I:C), which acts via TLR3. Poly C 16-22 toll like receptor 7 Gallus gallus 4-8 21929369-4 2012 The TLR7 ligand poly-C inhibited low-path influenza A growth in the chicken macrophage cell line HD-11 more effectively than poly(I:C), which acts via TLR3. Poly C 16-22 toll like receptor 3 Gallus gallus 151-155 22065573-7 2011 We demonstrate that the TLR3 ligand polyriboinosinic:polyribocytidylic acid (poly(I:C)) induces expression and nuclear translocation of YinYang1 where it interacts with the IFN-beta promoter and inhibits the binding of IRF7 to the latter. Poly C 53-75 toll like receptor 3 Homo sapiens 24-28 22065573-7 2011 We demonstrate that the TLR3 ligand polyriboinosinic:polyribocytidylic acid (poly(I:C)) induces expression and nuclear translocation of YinYang1 where it interacts with the IFN-beta promoter and inhibits the binding of IRF7 to the latter. Poly C 53-75 YY1 transcription factor Homo sapiens 136-144 22065573-7 2011 We demonstrate that the TLR3 ligand polyriboinosinic:polyribocytidylic acid (poly(I:C)) induces expression and nuclear translocation of YinYang1 where it interacts with the IFN-beta promoter and inhibits the binding of IRF7 to the latter. Poly C 53-75 interferon beta 1 Homo sapiens 173-181 22065573-7 2011 We demonstrate that the TLR3 ligand polyriboinosinic:polyribocytidylic acid (poly(I:C)) induces expression and nuclear translocation of YinYang1 where it interacts with the IFN-beta promoter and inhibits the binding of IRF7 to the latter. Poly C 53-75 interferon regulatory factor 7 Homo sapiens 219-223 21296697-0 2011 Toll-like receptor 3 ligand polyinosinic:polycytidylic acid enhances autoimmune disease in a retinal autoimmunity model. Poly C 41-59 toll like receptor 3 Homo sapiens 0-20 21996340-0 2011 Polyinosinic:polycytidylic acid induces protein kinase D-dependent disassembly of apical junctions and barrier dysfunction in airway epithelial cells. Poly C 13-31 protein kinase D1 Homo sapiens 40-56 21976648-4 2011 To further our understanding of the role of the viral nsp1 in these processes, using nsp1beta, a proteolytically processed functional product of nsp1 as bait, we have identified the cellular poly(C)-binding proteins 1 and 2 (PCBP1 and PCBP2) as two of its interaction partners. Poly C 191-198 SH2 domain containing 3A Homo sapiens 54-58 21976648-4 2011 To further our understanding of the role of the viral nsp1 in these processes, using nsp1beta, a proteolytically processed functional product of nsp1 as bait, we have identified the cellular poly(C)-binding proteins 1 and 2 (PCBP1 and PCBP2) as two of its interaction partners. Poly C 191-198 SH2 domain containing 3A Homo sapiens 85-89 21976648-4 2011 To further our understanding of the role of the viral nsp1 in these processes, using nsp1beta, a proteolytically processed functional product of nsp1 as bait, we have identified the cellular poly(C)-binding proteins 1 and 2 (PCBP1 and PCBP2) as two of its interaction partners. Poly C 191-198 poly(rC) binding protein 1 Homo sapiens 225-230 21976648-4 2011 To further our understanding of the role of the viral nsp1 in these processes, using nsp1beta, a proteolytically processed functional product of nsp1 as bait, we have identified the cellular poly(C)-binding proteins 1 and 2 (PCBP1 and PCBP2) as two of its interaction partners. Poly C 191-198 poly(rC) binding protein 2 Homo sapiens 235-240 21540291-5 2011 Both TLR3 and TLR4 can be activated by their agonists (polyinosinic:polycytidylic acid and lipopolysaccharide) in Leydig cells and subsequently induce the production of inflammatory factors, such as IL-1beta, IL-6, TNF-alpha, and type 1 interferons (IFN) (IFN-alpha and IFN-beta). Poly C 68-86 toll-like receptor 3 Mus musculus 5-9 21540291-5 2011 Both TLR3 and TLR4 can be activated by their agonists (polyinosinic:polycytidylic acid and lipopolysaccharide) in Leydig cells and subsequently induce the production of inflammatory factors, such as IL-1beta, IL-6, TNF-alpha, and type 1 interferons (IFN) (IFN-alpha and IFN-beta). Poly C 68-86 toll-like receptor 4 Mus musculus 14-18 21540291-5 2011 Both TLR3 and TLR4 can be activated by their agonists (polyinosinic:polycytidylic acid and lipopolysaccharide) in Leydig cells and subsequently induce the production of inflammatory factors, such as IL-1beta, IL-6, TNF-alpha, and type 1 interferons (IFN) (IFN-alpha and IFN-beta). Poly C 68-86 tumor necrosis factor Mus musculus 215-224 21540291-5 2011 Both TLR3 and TLR4 can be activated by their agonists (polyinosinic:polycytidylic acid and lipopolysaccharide) in Leydig cells and subsequently induce the production of inflammatory factors, such as IL-1beta, IL-6, TNF-alpha, and type 1 interferons (IFN) (IFN-alpha and IFN-beta). Poly C 68-86 interferon alpha Mus musculus 256-265 21540291-5 2011 Both TLR3 and TLR4 can be activated by their agonists (polyinosinic:polycytidylic acid and lipopolysaccharide) in Leydig cells and subsequently induce the production of inflammatory factors, such as IL-1beta, IL-6, TNF-alpha, and type 1 interferons (IFN) (IFN-alpha and IFN-beta). Poly C 68-86 interferon beta 1, fibroblast Mus musculus 270-278 21964025-5 2011 Costimulation of primary human fibroblasts with IL-17 greatly enhanced respiratory syncytial virus-induced or synthetic dsRNA-based viral mimic polyinosinic:polycytidylic acid-induced expression of proinflammatory genes without affecting expression of IFN-beta-stimulated or IFN-stimulated genes. Poly C 157-175 interleukin 17A Homo sapiens 48-53 21563279-3 2011 We show that TLR3 triggering by polyinosinic:polycytidylic acid dramatically amplifies, in a more significant manner than TLR4 triggering by lipopolysaccharide, the antiapoptotic effects that resting BM-MSC constitutively exert on PMN under coculture conditions, preserving a significant fraction of viable and functional PMN up to 72 hours. Poly C 45-63 toll like receptor 3 Homo sapiens 13-17 21278304-5 2011 METHODS: We compared the effects of transgenic VEGF(165) in mice treated with viral pathogen-associated molecular pattern polyinosinic:polycytidylic acid [poly(I:C)], mice treated with live virus, and control mice. Poly C 135-153 vascular endothelial growth factor A Mus musculus 47-51 21327636-2 2011 In the present study, we found that Polyinosinic:Polycytidylic Acid [Poly(I:C)] and CpG oligodeoxynucleotide 1826 [CpG], agonists for TLR 3 and 9, respectively, potently activated adoptively transferred T cells against a murine model of established melanoma. Poly C 49-67 toll-like receptor 3 Mus musculus 134-145 21106850-3 2011 Blockade of Akt by a dominant-negative mutant or by short interfering RNA decreased IRF3 activation and IFN-beta expression induced by polyinosinic:polycytidylic acid [poly(I:C)], LPS, TRIF, and TBK1. Poly C 148-166 thymoma viral proto-oncogene 1 Mus musculus 12-15 21106850-3 2011 Blockade of Akt by a dominant-negative mutant or by short interfering RNA decreased IRF3 activation and IFN-beta expression induced by polyinosinic:polycytidylic acid [poly(I:C)], LPS, TRIF, and TBK1. Poly C 148-166 interferon regulatory factor 3 Mus musculus 84-88 21106850-3 2011 Blockade of Akt by a dominant-negative mutant or by short interfering RNA decreased IRF3 activation and IFN-beta expression induced by polyinosinic:polycytidylic acid [poly(I:C)], LPS, TRIF, and TBK1. Poly C 148-166 interferon beta 1, fibroblast Mus musculus 104-112 20817677-2 2011 PCBP4, also called MCG10, is an RBP belonging to the poly(C)-binding protein family and a target of p53 tumor suppressor. Poly C 53-60 poly(rC) binding protein 4 Mus musculus 0-5 20817677-2 2011 PCBP4, also called MCG10, is an RBP belonging to the poly(C)-binding protein family and a target of p53 tumor suppressor. Poly C 53-60 retinol binding protein 4, plasma Mus musculus 32-35 20881901-9 2011 Treatment with not only poly I:C but also LPS induced pancreatitis in IL-10-deficient mice but not in wild-type mice. Poly C 24-32 interleukin 10 Mus musculus 70-75 21674051-5 2011 METHODOLOGY/PRINCIPAL FINDINGS: We report that polyinosinic:polycytidylic acid (PolyIC, synthetic analogue of dsRNA) induces dramatic apoptosis of mouse splenic conventional DC (cDC) in vivo, predominantly affecting the CD8alpha subset, as shown by flow cytometry-based analysis of splenic DC subsets. Poly C 60-78 CD8 antigen, alpha chain Mus musculus 220-228 20483774-4 2010 A genome-scale functional screening of a transcript library from brain tumors revealed that the microtubule regulator stathmin is an activator of TLR3-dependent signaling in astrocytes, inducing the same set of neuroprotective factors as the known TLR3 agonist polyinosinic:polycytidylic acid. Poly C 274-292 stathmin 1 Homo sapiens 118-126 20932317-7 2010 Of the seven reported frameshift mutations occurring in poly C-tracts in RAI1, four cases (~57%) occur at this heptameric C-tract. Poly C 56-62 retinoic acid induced 1 Homo sapiens 73-77 20519371-0 2010 The poly(c)-binding protein-1 regulates expression of the androgen receptor. Poly C 4-11 androgen receptor Homo sapiens 58-75 20610642-4 2010 NLRC5 expression was strongly induced by IFN-gamma and more modestly by LPS and polyinosinic:polycytidylic acid. Poly C 93-111 NLR family CARD domain containing 5 Homo sapiens 0-5 20827338-6 2010 Treatment of HSG cells with polyinosinic: polycytidylic acid (poly(I:C)) significantly increased interferon-gamma-inducible protein 10 (IP-10), interferoninducible T-cell alpha chemoattractant (I-TAC), and regulated on activation, normal T-cells expressed and secreted (RANTES) gene expressions in a concentration-dependent manner. Poly C 42-60 C-X-C motif chemokine ligand 10 Homo sapiens 97-134 20827338-6 2010 Treatment of HSG cells with polyinosinic: polycytidylic acid (poly(I:C)) significantly increased interferon-gamma-inducible protein 10 (IP-10), interferoninducible T-cell alpha chemoattractant (I-TAC), and regulated on activation, normal T-cells expressed and secreted (RANTES) gene expressions in a concentration-dependent manner. Poly C 42-60 C-X-C motif chemokine ligand 10 Homo sapiens 136-141 20827338-6 2010 Treatment of HSG cells with polyinosinic: polycytidylic acid (poly(I:C)) significantly increased interferon-gamma-inducible protein 10 (IP-10), interferoninducible T-cell alpha chemoattractant (I-TAC), and regulated on activation, normal T-cells expressed and secreted (RANTES) gene expressions in a concentration-dependent manner. Poly C 42-60 C-X-C motif chemokine ligand 11 Homo sapiens 144-192 20827338-6 2010 Treatment of HSG cells with polyinosinic: polycytidylic acid (poly(I:C)) significantly increased interferon-gamma-inducible protein 10 (IP-10), interferoninducible T-cell alpha chemoattractant (I-TAC), and regulated on activation, normal T-cells expressed and secreted (RANTES) gene expressions in a concentration-dependent manner. Poly C 42-60 C-X-C motif chemokine ligand 11 Homo sapiens 194-199 20827338-6 2010 Treatment of HSG cells with polyinosinic: polycytidylic acid (poly(I:C)) significantly increased interferon-gamma-inducible protein 10 (IP-10), interferoninducible T-cell alpha chemoattractant (I-TAC), and regulated on activation, normal T-cells expressed and secreted (RANTES) gene expressions in a concentration-dependent manner. Poly C 42-60 C-C motif chemokine ligand 5 Homo sapiens 270-276 20668230-6 2010 When mAb heavy chain was engineered to express HIV Gag p24, the fusion mAb induced interferon-gamma- and interleukin-2-producing CD4(+) T cells in hDEC205 transgenic mice, if polynocinic polycytidylic acid was coadministered as an adjuvant. Poly C 187-205 melanoma antigen Mus musculus 51-54 20668230-6 2010 When mAb heavy chain was engineered to express HIV Gag p24, the fusion mAb induced interferon-gamma- and interleukin-2-producing CD4(+) T cells in hDEC205 transgenic mice, if polynocinic polycytidylic acid was coadministered as an adjuvant. Poly C 187-205 cytochrome P450, family 2, subfamily b, polypeptide 10 Mus musculus 55-58 20224598-5 2010 Promoter, DNA pull-down and chromatin-immunoprecipitation assays revealed that hnRNP K directly interacts with the poly(C) element on the FLIP promoter, resulting in transcriptional activation. Poly C 115-122 heterogeneous nuclear ribonucleoprotein K Homo sapiens 79-86 20224598-6 2010 Through iTRAQ-mass spectrometric identification of proteins differentially associated with the poly(C) element or its mutant, nucleolin was determined to be a cofactor of hnRNP K for FLIP activation. Poly C 95-102 nucleolin Homo sapiens 126-135 20224598-6 2010 Through iTRAQ-mass spectrometric identification of proteins differentially associated with the poly(C) element or its mutant, nucleolin was determined to be a cofactor of hnRNP K for FLIP activation. Poly C 95-102 heterogeneous nuclear ribonucleoprotein K Homo sapiens 171-178 20298789-10 2010 IRF8 expression in stimulated trout splenocytes was significantly up-regulated by polyinosinic:polycytidylic acid (poly I:C), trout recombinant (r)IL-15, phorbol 12-myristate 13-acetate (PMA), and phytohaemagglutinin (PHA) treatment whilst remaining refractory towards lipopolysaccharide (LPS) treatment. Poly C 95-113 interferon regulatory factor 8 Homo sapiens 0-4 20511554-3 2010 Mixtures that included the TLR7/8 agonists R848 or CL075, combined with the TLR3 agonist polyinosinic:polycytidylic acid, yielded 3-d mature DCs that secreted high levels of IL-12(p70), showed strong chemotaxis to CCR7 ligands, and had a positive costimulatory potential. Poly C 102-120 toll like receptor 3 Homo sapiens 76-80 20483774-4 2010 A genome-scale functional screening of a transcript library from brain tumors revealed that the microtubule regulator stathmin is an activator of TLR3-dependent signaling in astrocytes, inducing the same set of neuroprotective factors as the known TLR3 agonist polyinosinic:polycytidylic acid. Poly C 274-292 toll like receptor 3 Homo sapiens 146-150 20164430-0 2010 Cutting edge: polyinosinic:polycytidylic acid boosts the generation of memory CD8 T cells through melanoma differentiation-associated protein 5 expressed in stromal cells. Poly C 27-45 interferon induced with helicase C domain 1 Mus musculus 98-143 20080226-1 2010 OBJECTIVE: The purpose of this study was to explore the potential of toll-like receptor-3 stimulation, with polyI:C(12)U (poly[l].poly[C(12),U]; rintatolimod [Ampligen; Hemispherx Biopharma, Philadelphia, PA]) to enhance bioactivity of cancer immunotherapies. Poly C 130-136 toll-like receptor 3 Mus musculus 69-89 20562257-6 2010 IFN-gamma, a cytokine linked to atherosclerosis and graft arteriosclerosis, potentiated the inflammatory responses of intact arteries and cultured vascular smooth muscle cells (VSMCs) to polyinosinic:polycytidylic acid [poly(I:C)] and was necessary for inflammatory responses of VSMC to self-RNA derived from autologous cells. Poly C 200-218 interferon gamma Homo sapiens 0-9 20167870-2 2010 We investigated the role of polyriboinosinic:polycytidylic acid (poly I:C), a replication-competent viral double-stranded RNA mimic and a specific agonist that recognizes the cellular sensor Toll-like receptor 3 (TLR3), in regulating Valpha14iNKT cell activation. Poly C 45-63 toll-like receptor 3 Mus musculus 191-211 20167870-2 2010 We investigated the role of polyriboinosinic:polycytidylic acid (poly I:C), a replication-competent viral double-stranded RNA mimic and a specific agonist that recognizes the cellular sensor Toll-like receptor 3 (TLR3), in regulating Valpha14iNKT cell activation. Poly C 45-63 toll-like receptor 3 Mus musculus 213-217 20181884-6 2010 CpG-B ODN inhibited induction of IFN-alphabeta by agonists of multiple receptors, including MyD88-dependent TLRs (CpG-A ODN signaling via TLR9, or R837 or Sendai virus signaling via TLR7) and MyD88-independent receptors (polyinosinic:polycytidylic acid signaling via TLR3 or ds break-DNA signaling via a cytosolic pathway). Poly C 234-252 interferon alpha 1 Homo sapiens 33-36 19748983-0 2009 TLR3 ligand polyinosinic:polycytidylic acid induces IL-17A and IL-21 synthesis in human Th cells. Poly C 25-43 toll like receptor 3 Homo sapiens 0-4 19632268-1 2009 Two new interferon stimulated gene 15 (ISG15) family members were identified in a subtractive cDNA library constructed from a mixture of head kidney and spleen of Atlantic cod (Gadus morhua) stimulated with polyinosinic:polycytidylic acid (poly I:C). Poly C 220-238 ISG15 ubiquitin like modifier Homo sapiens 39-44 19821527-0 2009 The beta2 integrin CD11b attenuates polyinosinic:polycytidylic acid-induced hepatitis by negatively regulating natural killer cell functions. Poly C 49-67 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 4-9 19821527-0 2009 The beta2 integrin CD11b attenuates polyinosinic:polycytidylic acid-induced hepatitis by negatively regulating natural killer cell functions. Poly C 49-67 integrin subunit alpha M Homo sapiens 19-24 19821527-7 2009 CD11b-deficient NK cells stimulated with or without the TLR3 ligand polyinosinic:polycytidylic acid [poly(I:C)] exhibited more potent cytotoxicity, and higher production of IFN-gamma and granzyme B. Poly C 81-99 integrin subunit alpha M Homo sapiens 0-5 19821527-7 2009 CD11b-deficient NK cells stimulated with or without the TLR3 ligand polyinosinic:polycytidylic acid [poly(I:C)] exhibited more potent cytotoxicity, and higher production of IFN-gamma and granzyme B. Poly C 81-99 toll like receptor 3 Homo sapiens 56-60 19821527-7 2009 CD11b-deficient NK cells stimulated with or without the TLR3 ligand polyinosinic:polycytidylic acid [poly(I:C)] exhibited more potent cytotoxicity, and higher production of IFN-gamma and granzyme B. Poly C 81-99 interferon gamma Homo sapiens 173-182 19821527-7 2009 CD11b-deficient NK cells stimulated with or without the TLR3 ligand polyinosinic:polycytidylic acid [poly(I:C)] exhibited more potent cytotoxicity, and higher production of IFN-gamma and granzyme B. Poly C 81-99 granzyme B Homo sapiens 187-197 19748983-0 2009 TLR3 ligand polyinosinic:polycytidylic acid induces IL-17A and IL-21 synthesis in human Th cells. Poly C 25-43 interleukin 17A Homo sapiens 52-58 19748983-0 2009 TLR3 ligand polyinosinic:polycytidylic acid induces IL-17A and IL-21 synthesis in human Th cells. Poly C 25-43 interleukin 21 Homo sapiens 63-68 19748983-6 2009 We investigated the expression of IL-17A and IL-21 in human CD4+ T cells in response to stimulation with the TLR3 ligand polyinosinic:polycytidylic acid (poly(I:C)) and the TLR9 ligand CpG. Poly C 134-152 interleukin 17A Homo sapiens 34-40 19748983-6 2009 We investigated the expression of IL-17A and IL-21 in human CD4+ T cells in response to stimulation with the TLR3 ligand polyinosinic:polycytidylic acid (poly(I:C)) and the TLR9 ligand CpG. Poly C 134-152 interleukin 21 Homo sapiens 45-50 19748983-6 2009 We investigated the expression of IL-17A and IL-21 in human CD4+ T cells in response to stimulation with the TLR3 ligand polyinosinic:polycytidylic acid (poly(I:C)) and the TLR9 ligand CpG. Poly C 134-152 toll like receptor 3 Homo sapiens 109-113 19620256-8 2009 UV-cross-linking studies identify a approximately 44-kDa protein as a major TH mRNA 3"-UTR binding factor, and cAMP induces the 40- to 42-kDa poly(C)-binding protein-2 (PCBP2) in MN9D cells. Poly C 142-149 poly(rC) binding protein 2 Mus musculus 169-174 19546225-8 2009 Reciprocally, depletion of PLK1 can increase IFN induction in response to RIG-I/SeV or RIG-I/poly(I)-poly(C) treatments. Poly C 101-108 polo like kinase 1 Homo sapiens 27-31 19710456-4 2009 We examined the expression and function of B7 family costimulatory molecules on DCs after activation with the TLR3 agonist, polyinosinic:polycytidylic acid. Poly C 137-155 toll like receptor 3 Homo sapiens 110-114 19441079-10 2009 ROD1 binding to C21 was strongly inhibited by synthetic RNAs in the order poly A > poly U > poly G = poly C and was weakly inhibited by a synthetic phosphorylated peptide mimicking the C-terminal domain of RNA polymerase II. Poly C 107-113 polypyrimidine tract binding protein 3 Homo sapiens 0-4 19441079-10 2009 ROD1 binding to C21 was strongly inhibited by synthetic RNAs in the order poly A > poly U > poly G = poly C and was weakly inhibited by a synthetic phosphorylated peptide mimicking the C-terminal domain of RNA polymerase II. Poly C 107-113 TBL1X/Y related 1 Homo sapiens 16-19 19546225-8 2009 Reciprocally, depletion of PLK1 can increase IFN induction in response to RIG-I/SeV or RIG-I/poly(I)-poly(C) treatments. Poly C 101-108 interferon alpha 1 Homo sapiens 45-48 19164348-2 2009 FcepsilonRI-mediated activation of human MCs upregulated TSLP mRNA expression by 5.2+/-2.9-fold, while activation of the MCs using lipopolysaccharide and polyriboinosinic:polyribocytidylic acid failed to upregulate TSLP. Poly C 171-193 Fc epsilon receptor Ia Homo sapiens 0-11 19656458-0 2009 Variations in the length of poly-C and poly-T tracts in intron 3 of the human ferrochelatase gene. Poly C 28-34 ferrochelatase Homo sapiens 78-92 19564349-1 2009 Relative to several other toll-like receptor (TLR) agonists, we found polyinosinic:polycytidylic acid (poly IC) to be the most effective adjuvant for Th1 CD4(+) T cell responses to a dendritic cell (DC)-targeted HIV gag protein vaccine in mice. Poly C 83-101 negative elongation factor complex member C/D, Th1l Mus musculus 150-153 19564349-1 2009 Relative to several other toll-like receptor (TLR) agonists, we found polyinosinic:polycytidylic acid (poly IC) to be the most effective adjuvant for Th1 CD4(+) T cell responses to a dendritic cell (DC)-targeted HIV gag protein vaccine in mice. Poly C 83-101 CD4 antigen Mus musculus 154-157 19686199-6 2009 Administration of TLR ligands, lipopolysaccharide, and double-stranded RNA polyinosinic:polycytidylic acid, which mimics bacterial or viral infection, activates the IFN signaling pathways, upregulates the expression of IFN-inducible genes, and downregulates the expression of c-fos in taste buds. Poly C 88-106 interferon alpha 1 Homo sapiens 165-168 19686199-6 2009 Administration of TLR ligands, lipopolysaccharide, and double-stranded RNA polyinosinic:polycytidylic acid, which mimics bacterial or viral infection, activates the IFN signaling pathways, upregulates the expression of IFN-inducible genes, and downregulates the expression of c-fos in taste buds. Poly C 88-106 interferon alpha 1 Homo sapiens 219-222 19686199-6 2009 Administration of TLR ligands, lipopolysaccharide, and double-stranded RNA polyinosinic:polycytidylic acid, which mimics bacterial or viral infection, activates the IFN signaling pathways, upregulates the expression of IFN-inducible genes, and downregulates the expression of c-fos in taste buds. Poly C 88-106 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 276-281 19656458-1 2009 The third intron of human ferrochelatase (FECH) gene contains according to NCBI, a poly-C (11) and a poly-T (24) tracts which are located approximately 900 bp upstream from the known splice modulating SNP IVS3-48 c/t. Poly C 83-89 ferrochelatase Homo sapiens 26-40 19656458-1 2009 The third intron of human ferrochelatase (FECH) gene contains according to NCBI, a poly-C (11) and a poly-T (24) tracts which are located approximately 900 bp upstream from the known splice modulating SNP IVS3-48 c/t. Poly C 83-89 ferrochelatase Homo sapiens 42-46 19656458-3 2009 During the course of mutation analysis in the FECH gene among EPP patients, we observed variations in the length of the poly-C and poly-T tracts. Poly C 120-126 ferrochelatase Homo sapiens 46-50 19282652-4 2009 An analogue of viral double-stranded RNA, polyinosinic:polycytidylic acid (poly I:C), which is recognized by TLR3, was injected into autoimmune-prone strains: MRL/Mp mice (MRL/+), MRL/Mp mice with a deficit of Fas (MRL/lpr) and MRL/Mp mice with a deficit of functional FasL (MRL/gld). Poly C 55-73 toll-like receptor 3 Mus musculus 109-113 19211566-0 2009 Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest. Poly C 17-24 poly(rC) binding protein 2 Homo sapiens 55-63 19211566-0 2009 Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest. Poly C 17-24 tumor protein p53 Homo sapiens 89-92 19211566-0 2009 Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest. Poly C 17-24 cyclin dependent kinase inhibitor 1A Homo sapiens 153-159 18845337-6 2009 Based on our previous findings that AML cells produce IFN-alpha upon electroporation with the synthetic double-stranded (ds)RNA polyriboinosinic polyribocytidylic acid (poly(I:C)), we hypothesized that dsRNA-loaded tumor cells provide both signals to elicit an NK cell-driven IFN-gamma production. Poly C 145-167 interferon alpha 1 Homo sapiens 54-63 18845337-6 2009 Based on our previous findings that AML cells produce IFN-alpha upon electroporation with the synthetic double-stranded (ds)RNA polyriboinosinic polyribocytidylic acid (poly(I:C)), we hypothesized that dsRNA-loaded tumor cells provide both signals to elicit an NK cell-driven IFN-gamma production. Poly C 145-167 interferon gamma Homo sapiens 276-285 19166911-3 2009 Upon the activation of Toll-like receptor (TLR)-3 expressed in the neuronal cells by polyriboinosinic polyribocytidylic acid (PolyI:C), both IFN-lambda1 and IFN-lambda2/3 expression was significantly induced. Poly C 126-133 interferon lambda 1 Homo sapiens 141-152 19166911-3 2009 Upon the activation of Toll-like receptor (TLR)-3 expressed in the neuronal cells by polyriboinosinic polyribocytidylic acid (PolyI:C), both IFN-lambda1 and IFN-lambda2/3 expression was significantly induced. Poly C 126-133 interferon lambda 2 Homo sapiens 157-168 19234166-9 2009 Our studies also show that the ability of RIG-I to respond to stimulation with polyinosinic:polycytidylic acid is abolished when its interaction with HSP90 is inhibited. Poly C 92-110 DExD/H-box helicase 58 Homo sapiens 42-47 19234166-9 2009 Our studies also show that the ability of RIG-I to respond to stimulation with polyinosinic:polycytidylic acid is abolished when its interaction with HSP90 is inhibited. Poly C 92-110 heat shock protein 90 alpha family class A member 1 Homo sapiens 150-155 18262679-1 2008 Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA and its synthetic analog polyriboinosinic:polyribocytidylic acid (poly(I:C)) and induces type I interferon (IFN), inflammatory cytokine/chemokine production and dendritic cell (DC) maturation via the adaptor protein TICAM-1 (also called TRIF). Poly C 107-129 toll-like receptor 3 Mus musculus 0-20 19201880-4 2009 In this study, we show that S100A8 was induced in murine macrophages, and S100A8 and S100A9 in human monocytes and macrophages, by polyinosinic:polycytidylic acid, a dsRNA mimetic. Poly C 144-162 S100 calcium binding protein A8 (calgranulin A) Mus musculus 28-34 19201880-4 2009 In this study, we show that S100A8 was induced in murine macrophages, and S100A8 and S100A9 in human monocytes and macrophages, by polyinosinic:polycytidylic acid, a dsRNA mimetic. Poly C 144-162 S100 calcium binding protein A8 (calgranulin A) Mus musculus 74-80 19201880-4 2009 In this study, we show that S100A8 was induced in murine macrophages, and S100A8 and S100A9 in human monocytes and macrophages, by polyinosinic:polycytidylic acid, a dsRNA mimetic. Poly C 144-162 S100 calcium binding protein A9 (calgranulin B) Mus musculus 85-91 19201880-8 2009 Like IL-10, S100 induction by polyinosinic:polycytidylic acid and by LPS was inhibited by the specific PKR inhibitor 2-aminopurine, indicating a novel IL-10, PKR-dependent pathway. Poly C 43-61 interleukin 10 Homo sapiens 5-10 19201880-8 2009 Like IL-10, S100 induction by polyinosinic:polycytidylic acid and by LPS was inhibited by the specific PKR inhibitor 2-aminopurine, indicating a novel IL-10, PKR-dependent pathway. Poly C 43-61 S100 calcium binding protein B Homo sapiens 12-16 19201880-8 2009 Like IL-10, S100 induction by polyinosinic:polycytidylic acid and by LPS was inhibited by the specific PKR inhibitor 2-aminopurine, indicating a novel IL-10, PKR-dependent pathway. Poly C 43-61 interleukin 10 Homo sapiens 151-156 19038458-3 2009 We provide evidence that Vero cells are deficient in their ability to mount an IRF-3-dependent, IFN-independent antiviral response against either incoming virus particles or polyinosinic:polycytidylic acid (pIC), a dsRNA mimetic. Poly C 187-205 interferon regulatory factor 3 Chlorocebus sabaeus 79-84 19590242-6 2009 METHODS: Expression of PAI-1 and t-PA in immortalized human MC stimulated with polyriboinosinic:polyribocytidylic acid [poly(I:C)] RNA and cytokines were analyzed by real-time RT-PCR and ELISA. Poly C 96-118 serpin family E member 1 Homo sapiens 23-28 18266974-4 2008 We identified PARP-1 by affinity column chromatography using the double-stranded poly(C) element, followed by two-dimensional gel electrophoresis and MALDI-TOF mass spectrometry. Poly C 81-88 poly (ADP-ribose) polymerase family, member 1 Mus musculus 14-20 18266974-5 2008 PARP-1 binding to the poly(C) sequence of the MOR gene was sequence-specific as confirmed by the supershift assay. Poly C 22-29 poly (ADP-ribose) polymerase family, member 1 Mus musculus 0-6 18266974-5 2008 PARP-1 binding to the poly(C) sequence of the MOR gene was sequence-specific as confirmed by the supershift assay. Poly C 22-29 opioid receptor, mu 1 Mus musculus 46-49 18266974-6 2008 In cotransfection studies, PARP-1 repressed the MOR promoter only when the poly(C) sequence was intact. Poly C 75-82 poly (ADP-ribose) polymerase family, member 1 Mus musculus 27-33 18266974-6 2008 In cotransfection studies, PARP-1 repressed the MOR promoter only when the poly(C) sequence was intact. Poly C 75-82 opioid receptor, mu 1 Mus musculus 48-51 18266974-8 2008 Chromatin immunoprecipitation assays showed specific binding of PARP-1 to the double-stranded poly(C) element essential for the MOR promoter. Poly C 94-101 poly (ADP-ribose) polymerase family, member 1 Mus musculus 64-70 18266974-8 2008 Chromatin immunoprecipitation assays showed specific binding of PARP-1 to the double-stranded poly(C) element essential for the MOR promoter. Poly C 94-101 opioid receptor, mu 1 Mus musculus 128-131 18266974-10 2008 Our data suggest that PARP-1 can function as a repressor of MOR transcription dependent on the MOR poly(C) sequence. Poly C 99-106 poly (ADP-ribose) polymerase family, member 1 Mus musculus 22-28 18266974-10 2008 Our data suggest that PARP-1 can function as a repressor of MOR transcription dependent on the MOR poly(C) sequence. Poly C 99-106 opioid receptor, mu 1 Mus musculus 60-63 18266974-10 2008 Our data suggest that PARP-1 can function as a repressor of MOR transcription dependent on the MOR poly(C) sequence. Poly C 99-106 opioid receptor, mu 1 Mus musculus 95-98 18941247-3 2008 Polyinosinic:polycytidylic acid (poly(I:C)) is a synthetic mimetic of viral dsRNA that is known to interact either with endosomal TLR3 (not expressed by human neutrophils) or with cytoplasmic RNA helicases such as melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene I (RIG-I). Poly C 13-31 toll like receptor 3 Homo sapiens 130-134 18941247-3 2008 Polyinosinic:polycytidylic acid (poly(I:C)) is a synthetic mimetic of viral dsRNA that is known to interact either with endosomal TLR3 (not expressed by human neutrophils) or with cytoplasmic RNA helicases such as melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene I (RIG-I). Poly C 13-31 interferon induced with helicase C domain 1 Homo sapiens 214-256 18941247-3 2008 Polyinosinic:polycytidylic acid (poly(I:C)) is a synthetic mimetic of viral dsRNA that is known to interact either with endosomal TLR3 (not expressed by human neutrophils) or with cytoplasmic RNA helicases such as melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene I (RIG-I). Poly C 13-31 interferon induced with helicase C domain 1 Homo sapiens 258-262 18941247-3 2008 Polyinosinic:polycytidylic acid (poly(I:C)) is a synthetic mimetic of viral dsRNA that is known to interact either with endosomal TLR3 (not expressed by human neutrophils) or with cytoplasmic RNA helicases such as melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene I (RIG-I). Poly C 13-31 DExD/H-box helicase 58 Homo sapiens 268-298 18941247-3 2008 Polyinosinic:polycytidylic acid (poly(I:C)) is a synthetic mimetic of viral dsRNA that is known to interact either with endosomal TLR3 (not expressed by human neutrophils) or with cytoplasmic RNA helicases such as melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene I (RIG-I). Poly C 13-31 DExD/H-box helicase 58 Homo sapiens 300-305 21479492-3 2008 Recently, it was demonstrated that polyinosinic acid:polycytidylic acid [poly(I):poly(C)], a synthetic dsRNA analogue, induced the expression of RIG-I in various cell types, such as vascular endothelial cells and gingival fibroblasts. Poly C 53-71 DEAD/H box helicase 58 Mus musculus 145-150 21479492-3 2008 Recently, it was demonstrated that polyinosinic acid:polycytidylic acid [poly(I):poly(C)], a synthetic dsRNA analogue, induced the expression of RIG-I in various cell types, such as vascular endothelial cells and gingival fibroblasts. Poly C 81-88 DEAD/H box helicase 58 Mus musculus 145-150 21479492-4 2008 However, it remains unclear whether RIG-I is induced in osteoblasts in response to poly(I):poly(C). Poly C 91-98 DEAD/H box helicase 58 Mus musculus 36-41 21479492-5 2008 In the present study, we investigated the effects of poly(I):poly(C) on the expression of RIG-I in mouse osteoblastic MC3T3-E1(E1) cells. Poly C 61-68 DEAD/H box helicase 58 Mus musculus 90-95 21479492-6 2008 We found that poly(I):poly(C) increased the expression level of RIG-I in E1 cells, and that recombinant interferon-beta (IFN-beta) induced the expression of RIG-I mRNA in E1 cells. Poly C 22-29 DEAD/H box helicase 58 Mus musculus 64-69 21479492-7 2008 An anti-IFN-beta neu-tralizing antibody partially inhibited poly(I):poly(C)-induced RIG-I expression. Poly C 68-75 interferon beta 1, fibroblast Mus musculus 8-16 21479492-7 2008 An anti-IFN-beta neu-tralizing antibody partially inhibited poly(I):poly(C)-induced RIG-I expression. Poly C 68-75 DEAD/H box helicase 58 Mus musculus 84-89 21479492-8 2008 These results indicate that RIG-I production is induced by poly(I):poly(C)-provoked IFN-beta in mouse osteoblastic E1 cells. Poly C 67-74 DEAD/H box helicase 58 Mus musculus 28-33 21479492-8 2008 These results indicate that RIG-I production is induced by poly(I):poly(C)-provoked IFN-beta in mouse osteoblastic E1 cells. Poly C 67-74 interferon beta 1, fibroblast Mus musculus 84-92 18712788-8 2008 However, KCs isolated from polyinosinic:polycytidylic acid-treated mice expressed significantly higher levels of MHC II and costimulatory molecules than did naive KCs and could stimulate stronger T cell responses. Poly C 40-58 histocompatibility-2, MHC Mus musculus 113-119 18725521-4 2008 In this study, we show that polyinosinic:polycytidylic acid (poly[I:C]) and lipopolysaccharide stimulation of macrophages induces pro-IL-1beta processing via a Toll/IL-1R domain-containing adaptor-inducing interferon-beta-dependent signaling pathway that is initiated by TLR3 and TLR4, respectively. Poly C 41-59 interleukin 1 beta Homo sapiens 130-142 18725521-4 2008 In this study, we show that polyinosinic:polycytidylic acid (poly[I:C]) and lipopolysaccharide stimulation of macrophages induces pro-IL-1beta processing via a Toll/IL-1R domain-containing adaptor-inducing interferon-beta-dependent signaling pathway that is initiated by TLR3 and TLR4, respectively. Poly C 41-59 toll like receptor 4 Homo sapiens 160-164 18725521-4 2008 In this study, we show that polyinosinic:polycytidylic acid (poly[I:C]) and lipopolysaccharide stimulation of macrophages induces pro-IL-1beta processing via a Toll/IL-1R domain-containing adaptor-inducing interferon-beta-dependent signaling pathway that is initiated by TLR3 and TLR4, respectively. Poly C 41-59 toll like receptor 3 Homo sapiens 271-275 18725521-4 2008 In this study, we show that polyinosinic:polycytidylic acid (poly[I:C]) and lipopolysaccharide stimulation of macrophages induces pro-IL-1beta processing via a Toll/IL-1R domain-containing adaptor-inducing interferon-beta-dependent signaling pathway that is initiated by TLR3 and TLR4, respectively. Poly C 41-59 toll like receptor 4 Homo sapiens 280-284 18505922-8 2008 Furthermore, polyinosinic:polycytidylic acid treatment of the IRF-overexpressing cells showed a more rapid induction of several IFN-regulated genes. Poly C 26-44 tripartite motif containing 63 Homo sapiens 62-65 18505922-8 2008 Furthermore, polyinosinic:polycytidylic acid treatment of the IRF-overexpressing cells showed a more rapid induction of several IFN-regulated genes. Poly C 26-44 interferon alpha 1 Homo sapiens 128-131 19211566-0 2009 Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest. Poly C 17-24 poly(rC) binding protein 1 Homo sapiens 42-50 19201850-6 2009 This correlates with a reduced ex vivo and in vivo cytotoxic potential of NK cells isolated from PKCtheta(-/-) mice treated with polyinosinic:polycytidylic acid. Poly C 142-160 protein kinase C, theta Mus musculus 97-105 19036430-2 2009 We have developed a model vaccine formulation containing ovalbumin (OVA) and the double-stranded RNA analog poly(inosinic acid)-poly(cytidylic acid) (poly(I:C)), a TLR3 agonist. Poly C 128-148 toll-like receptor 3 Mus musculus 164-168 18922172-9 2008 Functionally, exposure to potassium chloride or intracellular acidification and addition of polyinosinic:polycytidylic acid as mimics of neural activity and double stranded RNA, respectively, differentially affected FMR1 IRES activity. Poly C 105-123 fragile X messenger ribonucleoprotein 1 Homo sapiens 216-220 18453338-4 2008 We identified five poly(C)-binding proteins: heterogeneous nuclear ribonucleoprotein (hnRNP) K, alpha-complex proteins (alphaCP) alphaCP1, alphaCP2, alphaCP2-KL, and alphaCP3. Poly C 19-26 poly(rC) binding protein 3 Mus musculus 166-174 18262679-1 2008 Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA and its synthetic analog polyriboinosinic:polyribocytidylic acid (poly(I:C)) and induces type I interferon (IFN), inflammatory cytokine/chemokine production and dendritic cell (DC) maturation via the adaptor protein TICAM-1 (also called TRIF). Poly C 107-129 toll-like receptor 3 Mus musculus 22-26 18262679-1 2008 Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA and its synthetic analog polyriboinosinic:polyribocytidylic acid (poly(I:C)) and induces type I interferon (IFN), inflammatory cytokine/chemokine production and dendritic cell (DC) maturation via the adaptor protein TICAM-1 (also called TRIF). Poly C 107-129 toll-like receptor adaptor molecule 1 Mus musculus 281-288 18262679-1 2008 Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA and its synthetic analog polyriboinosinic:polyribocytidylic acid (poly(I:C)) and induces type I interferon (IFN), inflammatory cytokine/chemokine production and dendritic cell (DC) maturation via the adaptor protein TICAM-1 (also called TRIF). Poly C 107-129 toll-like receptor adaptor molecule 1 Mus musculus 302-306 17368049-5 2007 In both cell lines, Mx and vig-1 transcripts were induced by a dsRNA, poly inosinic: poly cytidylic acid (poly IC), and by Chum salmon reovirus (CSV). Poly C 85-104 radical S-adenosyl methionine domain-containing protein 2 Oncorhynchus mykiss 27-32 18471880-5 2008 Both RIG-I/MDA5 and TLR3 can bind polyriboinosinic:polyribocytidylic acid (poly(I:C)), the synthetic analog of viral dsRNA, and mediate type I IFN production. Poly C 51-73 DExD/H-box helicase 58 Homo sapiens 5-10 18471880-5 2008 Both RIG-I/MDA5 and TLR3 can bind polyriboinosinic:polyribocytidylic acid (poly(I:C)), the synthetic analog of viral dsRNA, and mediate type I IFN production. Poly C 51-73 interferon induced with helicase C domain 1 Homo sapiens 11-15 18471880-5 2008 Both RIG-I/MDA5 and TLR3 can bind polyriboinosinic:polyribocytidylic acid (poly(I:C)), the synthetic analog of viral dsRNA, and mediate type I IFN production. Poly C 51-73 toll like receptor 3 Homo sapiens 20-24 18191426-2 2008 Among synthetic double-stranded (ds) RNAs, polyriboinosinic: polyribocytidylic acid (poly I:C) activates to produce interferon (IFN) -beta, which plays an important role in anti-viral activity and host-defense. Poly C 61-83 interferon beta 1, fibroblast Mus musculus 116-138 18191426-2 2008 Among synthetic double-stranded (ds) RNAs, polyriboinosinic: polyribocytidylic acid (poly I:C) activates to produce interferon (IFN) -beta, which plays an important role in anti-viral activity and host-defense. Poly C 85-93 interferon beta 1, fibroblast Mus musculus 116-138 18191426-4 2008 To determine whether poly I:C-induced IFN-beta production is responsible for reduced spontaneous physical activity, we measured poly I:C-induced changes in voluntary wheel-running activity in mice. Poly C 21-29 interferon beta 1, fibroblast Mus musculus 38-46 18086896-6 2008 DOG-1 was previously implicated in poly(G)/poly(C) (G/C) tract maintenance during DNA replication. Poly C 43-50 DNA helicase Caenorhabditis elegans 0-5 18307775-11 2008 Erythrocytes exposed to heat-inactivated virus or to polyinosinic:polycytidylic acid (polyI:C) or to L-15 medium alone (negative control assays) had minimal late induction (<3.5 relative fold increase) of STAT1 and/or ISG15 and Mx genes, whereas erythrocytes exposed to UV-inactivated virus lacked any cytokine induction. Poly C 66-84 signal transducer and activator of transcription 1 Homo sapiens 208-213 18307775-11 2008 Erythrocytes exposed to heat-inactivated virus or to polyinosinic:polycytidylic acid (polyI:C) or to L-15 medium alone (negative control assays) had minimal late induction (<3.5 relative fold increase) of STAT1 and/or ISG15 and Mx genes, whereas erythrocytes exposed to UV-inactivated virus lacked any cytokine induction. Poly C 66-84 ISG15 ubiquitin like modifier Homo sapiens 221-226 17625070-0 2007 Novel function of the poly(C)-binding protein alpha CP3 as a transcriptional repressor of the mu opioid receptor gene. Poly C 22-29 poly(rC) binding protein 3 Mus musculus 46-55 17625070-0 2007 Novel function of the poly(C)-binding protein alpha CP3 as a transcriptional repressor of the mu opioid receptor gene. Poly C 22-29 opioid receptor, mu 1 Mus musculus 94-112 17625070-4 2007 alphaCP3 bound to the double-stranded poly(C) element essential for the mu opioid receptor (MOR) promoter and repressed the promoter activity at the transcriptional level. Poly C 38-45 poly(rC) binding protein 3 Mus musculus 0-8 17625070-4 2007 alphaCP3 bound to the double-stranded poly(C) element essential for the mu opioid receptor (MOR) promoter and repressed the promoter activity at the transcriptional level. Poly C 38-45 opioid receptor, mu 1 Mus musculus 72-90 17625070-4 2007 alphaCP3 bound to the double-stranded poly(C) element essential for the mu opioid receptor (MOR) promoter and repressed the promoter activity at the transcriptional level. Poly C 38-45 opioid receptor, mu 1 Mus musculus 92-95 17625070-5 2007 We identified alphaCP3 using affinity column chromatography containing the double-stranded poly(C) element and matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry. Poly C 91-98 poly(rC) binding protein 3 Mus musculus 14-22 17625070-6 2007 AlphaCP3 binding to the poly(C) sequence of the MOR gene was sequence specific, as confirmed by the supershift assay. Poly C 24-31 poly(rC) binding protein 3 Mus musculus 0-8 17625070-6 2007 AlphaCP3 binding to the poly(C) sequence of the MOR gene was sequence specific, as confirmed by the supershift assay. Poly C 24-31 opioid receptor, mu 1 Mus musculus 48-51 17625070-7 2007 In cotransfection studies, alphaCP3 repressed the MOR promoter only when the poly(C) sequence was intact. Poly C 77-84 poly(rC) binding protein 3 Mus musculus 27-35 17625070-7 2007 In cotransfection studies, alphaCP3 repressed the MOR promoter only when the poly(C) sequence was intact. Poly C 77-84 opioid receptor, mu 1 Mus musculus 50-53 18032677-5 2007 Activation of TLR3 by the synthetic ligand polyinosine:polycytidylic acid (poly I:C) or by mRNA rapidly causes growth cone collapse and irreversibly inhibits neurite extension independent of nuclear factor kappaB. Poly C 55-73 toll-like receptor 3 Mus musculus 14-18 17982052-3 2007 We now report that administration of the TLR agonists LPS (TLR4) or polyinosinic:polycytidylic acid (TLR3) to mice treated with costimulation blockade prevents alloreactive CD8(+) T cell deletion, primes alloreactive CTLs, and shortens allograft survival. Poly C 81-99 toll-like receptor 3 Mus musculus 101-105 17878381-3 2007 Treatment of RAW 264.7 murine macrophage-like cells with the dsRNA analog polyinosinic:polycytidylic acid (poly-IC) promotes the release of free arachidonic acid that is subsequently converted into PGE2 by the de novo-synthesized cyclooxygenase-2 (COX-2) enzyme. Poly C 87-105 prostaglandin-endoperoxide synthase 2 Mus musculus 230-246 17878381-3 2007 Treatment of RAW 264.7 murine macrophage-like cells with the dsRNA analog polyinosinic:polycytidylic acid (poly-IC) promotes the release of free arachidonic acid that is subsequently converted into PGE2 by the de novo-synthesized cyclooxygenase-2 (COX-2) enzyme. Poly C 87-105 prostaglandin-endoperoxide synthase 2 Mus musculus 248-253 17390082-4 2007 The increase in the IFN-beta mRNA level was apparent as early as 1 h after adding poly(I):poly(C) to the culture and peaked at 12 h. Stimulation with poly(I):poly(C) enhanced the expression of CXCL10 mRNA and TLR3 in E1 cells. Poly C 158-165 interferon beta 1, fibroblast Mus musculus 20-28 17483910-7 2007 The individual mutation of Arg(36), Asn (39), and Gln(40) resulted in a reduction in the catalytic activity of EDN on poly(U) and poly(C). Poly C 130-136 ribonuclease A family member 2 Homo sapiens 111-114 17581920-3 2007 ANG II activated hnRNP K as judged by binding to poly(C)- and poly(U)-agarose. Poly C 49-56 heterogeneous nuclear ribonucleoprotein K Homo sapiens 17-24 17345100-0 2007 STAT3 and COX-2 activation in the guinea-pig brain during fever induced by the Toll-like receptor-3 agonist polyinosinic:polycytidylic acid. Poly C 121-139 signal transducer and activator of transcription 3 Cavia porcellus 0-5 17345100-0 2007 STAT3 and COX-2 activation in the guinea-pig brain during fever induced by the Toll-like receptor-3 agonist polyinosinic:polycytidylic acid. Poly C 121-139 cytochrome c oxidase subunit II Cavia porcellus 10-15 17321719-1 2007 Poly inosinic:poly cytidylic acid (poly I:C) is a synthetic double-stranded RNA and is a ligand for the Toll like receptor-3. Poly C 14-33 toll-like receptor 3 Mus musculus 104-124 17651019-5 2007 In poly(I).poly(C)-DEAE-dextran-induced PK15 cells, the expression of IFN-alpha2, -alpha3, -alpha4, -alpha8, and -alpha9 after 6-h/24-h inducement in PK15 cells were observed. Poly C 11-18 interferon alpha-2 Sus scrofa 70-120 17651019-7 2007 The results of realtime quantitative PCR analysis suggested that the expression was time-dependent in pseudorabies virus/poly(I).poly(C)-DEAE-dextran-induced PK15 cells, but in the attenuated swine fever virus-infected PK15 system, the expression level of IFN-alpha subtypes was not obviously time dependent. Poly C 129-136 interferon-alpha-14 Sus scrofa 256-265 17368063-6 2007 NCCRP-1 gene expression was not induced by in vitro treatment of head kidney cells with polyinosinic polycytidylic acid (poly I:C) or lipopolysaccharide (LPS), or by in vivo injections with poly I:C or formalin killed Vibrio anguillarum. Poly C 190-198 F-box only protein 50 Ictalurus punctatus 0-7 17390082-1 2007 Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid:polycytidylic acid [poly(I):poly(C)], are recognized by toll-like receptor 3 (TLR3) that induces the production of IFN-beta in many cell types. Poly C 61-79 toll-like receptor 3 Mus musculus 117-137 17390082-1 2007 Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid:polycytidylic acid [poly(I):poly(C)], are recognized by toll-like receptor 3 (TLR3) that induces the production of IFN-beta in many cell types. Poly C 61-79 toll-like receptor 3 Mus musculus 139-143 17390082-1 2007 Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid:polycytidylic acid [poly(I):poly(C)], are recognized by toll-like receptor 3 (TLR3) that induces the production of IFN-beta in many cell types. Poly C 61-79 interferon beta 1, fibroblast Mus musculus 176-184 17390082-1 2007 Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid:polycytidylic acid [poly(I):poly(C)], are recognized by toll-like receptor 3 (TLR3) that induces the production of IFN-beta in many cell types. Poly C 89-96 toll-like receptor 3 Mus musculus 117-137 17390082-1 2007 Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid:polycytidylic acid [poly(I):poly(C)], are recognized by toll-like receptor 3 (TLR3) that induces the production of IFN-beta in many cell types. Poly C 89-96 toll-like receptor 3 Mus musculus 139-143 17390082-1 2007 Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid:polycytidylic acid [poly(I):poly(C)], are recognized by toll-like receptor 3 (TLR3) that induces the production of IFN-beta in many cell types. Poly C 89-96 interferon beta 1, fibroblast Mus musculus 176-184 17390082-3 2007 Poly(I):poly(C) markedly increased IFN-beta mRNA level in a dose-dependent manner. Poly C 8-15 interferon beta 1, fibroblast Mus musculus 35-43 17390082-4 2007 The increase in the IFN-beta mRNA level was apparent as early as 1 h after adding poly(I):poly(C) to the culture and peaked at 12 h. Stimulation with poly(I):poly(C) enhanced the expression of CXCL10 mRNA and TLR3 in E1 cells. Poly C 90-97 interferon beta 1, fibroblast Mus musculus 20-28 17390082-4 2007 The increase in the IFN-beta mRNA level was apparent as early as 1 h after adding poly(I):poly(C) to the culture and peaked at 12 h. Stimulation with poly(I):poly(C) enhanced the expression of CXCL10 mRNA and TLR3 in E1 cells. Poly C 90-97 chemokine (C-X-C motif) ligand 10 Mus musculus 193-199 17390082-4 2007 The increase in the IFN-beta mRNA level was apparent as early as 1 h after adding poly(I):poly(C) to the culture and peaked at 12 h. Stimulation with poly(I):poly(C) enhanced the expression of CXCL10 mRNA and TLR3 in E1 cells. Poly C 158-165 chemokine (C-X-C motif) ligand 10 Mus musculus 193-199 17390082-4 2007 The increase in the IFN-beta mRNA level was apparent as early as 1 h after adding poly(I):poly(C) to the culture and peaked at 12 h. Stimulation with poly(I):poly(C) enhanced the expression of CXCL10 mRNA and TLR3 in E1 cells. Poly C 158-165 toll-like receptor 3 Mus musculus 209-213 17390082-5 2007 Moreover, poly(I):poly(C) induced tyrosine phosphorylation of the transcription factor STAT1 in E1 cells. Poly C 18-25 signal transducer and activator of transcription 1 Mus musculus 87-92 17390082-6 2007 An anti-IFN-beta neutralizing antibody partially inhibited poly(I):poly(C)-induced CXCL10 mRNA, TLR3 mRNA and STAT1 phosphorylation. Poly C 67-74 interferon beta 1, fibroblast Mus musculus 8-16 17390082-6 2007 An anti-IFN-beta neutralizing antibody partially inhibited poly(I):poly(C)-induced CXCL10 mRNA, TLR3 mRNA and STAT1 phosphorylation. Poly C 67-74 chemokine (C-X-C motif) ligand 10 Mus musculus 83-89 17390082-6 2007 An anti-IFN-beta neutralizing antibody partially inhibited poly(I):poly(C)-induced CXCL10 mRNA, TLR3 mRNA and STAT1 phosphorylation. Poly C 67-74 toll-like receptor 3 Mus musculus 96-100 17390082-6 2007 An anti-IFN-beta neutralizing antibody partially inhibited poly(I):poly(C)-induced CXCL10 mRNA, TLR3 mRNA and STAT1 phosphorylation. Poly C 67-74 signal transducer and activator of transcription 1 Mus musculus 110-115 16870330-5 2007 Mutations in the poly(C)(8) tract of BHD were detected in 3 of 19 MSI-high cases (15.8%), and none of 11 MSI-low cases. Poly C 17-24 BHD Homo sapiens 37-40 17208592-5 2007 The effect of GILZ on LPS-, IL-1beta-, and polyinosinic:polycytidylic acid-induced NF-kappaB activation was assessed in BEAS-2B cells overexpressing GILZ. Poly C 56-74 TSC22 domain family member 3 Homo sapiens 14-18 17242365-7 2007 Pharmacological inhibition of the kinase JNK blocked induction of miR-155 in response to either polyriboinosinic:polyribocytidylic acid or TNF-alpha, suggesting that miR-155-inducing signals use the JNK pathway. Poly C 113-135 mitogen-activated protein kinase 8 Homo sapiens 41-44 17242365-7 2007 Pharmacological inhibition of the kinase JNK blocked induction of miR-155 in response to either polyriboinosinic:polyribocytidylic acid or TNF-alpha, suggesting that miR-155-inducing signals use the JNK pathway. Poly C 113-135 microRNA 155 Homo sapiens 66-73 17177965-8 2007 In vitro studies evaluating the cell source of these cytokines revealed that polyriboinosinic polyribocytidylic acid (poly I:C) activated retinal vascular endothelial cells produce sE-selectin, sICAM-1 and IFN-beta. Poly C 118-126 interferon beta 1 Homo sapiens 206-214 16824598-6 2007 Injection of cod with poly I:C strongly induced the expression of ISG15 in all organs investigated. Poly C 22-30 ISG15 ubiquitin like modifier Danio rerio 66-71 17208592-5 2007 The effect of GILZ on LPS-, IL-1beta-, and polyinosinic:polycytidylic acid-induced NF-kappaB activation was assessed in BEAS-2B cells overexpressing GILZ. Poly C 56-74 nuclear factor kappa B subunit 1 Homo sapiens 83-92 17208592-5 2007 The effect of GILZ on LPS-, IL-1beta-, and polyinosinic:polycytidylic acid-induced NF-kappaB activation was assessed in BEAS-2B cells overexpressing GILZ. Poly C 56-74 TSC22 domain family member 3 Homo sapiens 149-153 17208592-8 2007 Overexpression of GILZ in BEAS-2B cells significantly inhibited the ability of IL-1beta, LPS, and polyinosinic:polycytidylic acid to activate NF-kappaB, whereas knockdown of GILZ inhibited the ability of dexamethasone to suppress IL-1beta-induced chemokine expression. Poly C 111-129 TSC22 domain family member 3 Homo sapiens 18-22 17208592-8 2007 Overexpression of GILZ in BEAS-2B cells significantly inhibited the ability of IL-1beta, LPS, and polyinosinic:polycytidylic acid to activate NF-kappaB, whereas knockdown of GILZ inhibited the ability of dexamethasone to suppress IL-1beta-induced chemokine expression. Poly C 111-129 nuclear factor kappa B subunit 1 Homo sapiens 142-151 17014383-11 2007 dsRNA poly (I).poly (C), an activator of PKR protein, increased cell death when osteosarcoma cells were treated with a submaximal concentration of 2-ME. Poly C 15-23 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 41-44 17426136-4 2007 To reveal the molecular basis of poly(C)-sequence recognition, we have determined the crystal structure, at 1.6 A resolution, of PCBP2 KH3 domain in complex with a 7-nt DNA sequence (5"-AACCCTA-3") corresponding to one repeat of the C-rich strand of human telomeric DNA. Poly C 33-40 poly(rC) binding protein 2 Homo sapiens 129-134 18040816-4 2006 New studies were conducted to further evaluate the role of corticosterone in EtOH-mediated changes in production of interleukin-6 (IL-6), IL-10, and IL-12 in serum and peritoneal fluid in mice treated with poly I:C or lipopolysaccharide (LPS). Poly C 206-214 interleukin 6 Mus musculus 116-129 18040816-8 2006 Inhibition of corticosterone synthesis with aminoglutethimide prevented the increase in IL-10 production caused by EtOH plus poly I:C as compared to poly I:C only. Poly C 125-133 interleukin 10 Homo sapiens 88-93 18040816-8 2006 Inhibition of corticosterone synthesis with aminoglutethimide prevented the increase in IL-10 production caused by EtOH plus poly I:C as compared to poly I:C only. Poly C 149-157 interleukin 10 Homo sapiens 88-93 17192569-8 2006 In the poly I:C-induced fatigue rats, expression of IFN-alpha and 5-HTT increased, while extracellular concentration of 5-HT in the medial prefrontal cortex decreased, probably on account of the enhanced expression of 5-HTT. Poly C 7-15 huntingtin Rattus norvegicus 68-71 17192569-8 2006 In the poly I:C-induced fatigue rats, expression of IFN-alpha and 5-HTT increased, while extracellular concentration of 5-HT in the medial prefrontal cortex decreased, probably on account of the enhanced expression of 5-HTT. Poly C 7-15 huntingtin Rattus norvegicus 220-223 16982647-3 2006 Here we show that PKR"s kinase activity is stimulated in vitro 3- to 5-fold by siRNA duplexes with 19 bp and 2 nt 3"-overhangs, whereas the maximum activation observed for poly(I)*poly(C) was 17-fold over background under the same conditions. Poly C 180-186 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 18-21 16824598-8 2007 The expression of ISG15 in head kidney cells was also induced in vitro by treatment with poly I:C, but not significantly with LPS. Poly C 89-97 ISG15 ubiquitin like modifier Danio rerio 18-23 16904079-0 2006 Molecular basis underlying the poly C binding protein 1 as a regulator of the proximal promoter of mouse mu-opioid receptor gene. Poly C 31-37 opioid receptor, mu 1 Mus musculus 105-123 16714379-0 2006 Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Poly C 68-90 interferon induced with helicase C domain 1 Mus musculus 18-23 16714379-2 2006 Both RIG-I and mda-5 can bind polyriboinosinic:polyribocytidylic acid (polyI:C), the synthetic analog of viral dsRNA, and mediate type I IFN responses to polyI:C and multiple RNA viruses in vitro. Poly C 47-69 DEAD/H box helicase 58 Mus musculus 5-10 16714379-2 2006 Both RIG-I and mda-5 can bind polyriboinosinic:polyribocytidylic acid (polyI:C), the synthetic analog of viral dsRNA, and mediate type I IFN responses to polyI:C and multiple RNA viruses in vitro. Poly C 47-69 interferon induced with helicase C domain 1 Mus musculus 15-20 16623926-5 2006 The synthetic dsRNA analogue polyinosinic acid : polycytidylic acid [Poly(I : C)] could only stimulate IFN-alpha production in enriched mDC but not in pDC. Poly C 49-67 interferon alpha 1 Homo sapiens 103-112 16623926-5 2006 The synthetic dsRNA analogue polyinosinic acid : polycytidylic acid [Poly(I : C)] could only stimulate IFN-alpha production in enriched mDC but not in pDC. Poly C 49-67 chemokine (C-C motif) ligand 22 Mus musculus 136-139 16278674-7 2006 Single-stranded poly A, poly G and poly C, as well double-stranded A/T and G/C RNA competed with DNA for AIF binding with a similar efficiency, thus corroborating a computer-calculated molecular model in which the binding site within AIF is the same for distinct nucleic acid species, without a clear sequence specificity. Poly C 35-41 apoptosis inducing factor mitochondria associated 1 Homo sapiens 105-108 16982913-2 2006 To explore the spectrum of genes induced in human astrocytes by TLR3, we used a microarray approach and the analog polyriboinosinic polyribocytidylic acid (pIC) as ligand. Poly C 156-159 toll like receptor 3 Homo sapiens 64-68 16895973-8 2006 Inflammatory stimuli (LPS, polyinosinic:polycytidylic acid, or SAC) induced release of variable quantities of IL-10 from the cell surface. Poly C 40-58 interleukin 10 Homo sapiens 110-115 16682008-0 2006 Interplay of Sps and poly(C) binding protein 1 on the mu-opioid receptor gene expression. Poly C 21-27 opioid receptor, mu 1 Mus musculus 54-72 16624932-2 2006 Here, we describe that the IFN-beta released upon stimulation with lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (poly I:C) is responsible for a rapid and sustained signal transducer and activator of transcription 1 and 2 activation and expression of IFN-stimulated genes, such as the transcription factor IFN regulatory factor 7 and the chemokine CXC chemokine ligand 10. Poly C 108-126 interferon beta 1 Homo sapiens 27-35 16624932-2 2006 Here, we describe that the IFN-beta released upon stimulation with lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (poly I:C) is responsible for a rapid and sustained signal transducer and activator of transcription 1 and 2 activation and expression of IFN-stimulated genes, such as the transcription factor IFN regulatory factor 7 and the chemokine CXC chemokine ligand 10. Poly C 108-126 signal transducer and activator of transcription 1 Homo sapiens 179-235 16624932-2 2006 Here, we describe that the IFN-beta released upon stimulation with lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (poly I:C) is responsible for a rapid and sustained signal transducer and activator of transcription 1 and 2 activation and expression of IFN-stimulated genes, such as the transcription factor IFN regulatory factor 7 and the chemokine CXC chemokine ligand 10. Poly C 108-126 interferon alpha 1 Homo sapiens 27-30 16624932-2 2006 Here, we describe that the IFN-beta released upon stimulation with lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (poly I:C) is responsible for a rapid and sustained signal transducer and activator of transcription 1 and 2 activation and expression of IFN-stimulated genes, such as the transcription factor IFN regulatory factor 7 and the chemokine CXC chemokine ligand 10. Poly C 108-126 interferon alpha 1 Homo sapiens 265-268 16518394-4 2006 Using pre-T cell-specific, mature T cell-specific and poly(I).poly(C)-inducible deletions of Smo and antagonists of Smo signaling, we report here that Hh is an essential positive regulator of T cell progenitor differentiation. Poly C 62-69 smoothened, frizzled class receptor Homo sapiens 93-96 16518394-4 2006 Using pre-T cell-specific, mature T cell-specific and poly(I).poly(C)-inducible deletions of Smo and antagonists of Smo signaling, we report here that Hh is an essential positive regulator of T cell progenitor differentiation. Poly C 62-69 smoothened, frizzled class receptor Homo sapiens 116-119 16308570-4 2005 In contrast, polyinosinic:polycytidylic acid strongly represses CpG"s as well as its own intrinsic ability to induce PDGF-B mRNA through type I IFN-mediated induction of Smad7, a negative regulator of Smad3/4. Poly C 26-44 platelet derived growth factor subunit B Homo sapiens 117-123 16308570-4 2005 In contrast, polyinosinic:polycytidylic acid strongly represses CpG"s as well as its own intrinsic ability to induce PDGF-B mRNA through type I IFN-mediated induction of Smad7, a negative regulator of Smad3/4. Poly C 26-44 interferon alpha 1 Homo sapiens 144-147 16308570-4 2005 In contrast, polyinosinic:polycytidylic acid strongly represses CpG"s as well as its own intrinsic ability to induce PDGF-B mRNA through type I IFN-mediated induction of Smad7, a negative regulator of Smad3/4. Poly C 26-44 SMAD family member 7 Homo sapiens 170-175 16308570-4 2005 In contrast, polyinosinic:polycytidylic acid strongly represses CpG"s as well as its own intrinsic ability to induce PDGF-B mRNA through type I IFN-mediated induction of Smad7, a negative regulator of Smad3/4. Poly C 26-44 SMAD family member 3 Homo sapiens 201-206 16186123-2 2005 To reveal the molecular basis of poly(C) sequence recognition, we have determined the crystal structure, at 1.7-A resolution, of PCBP2 KH1 in complex with a 7-nucleotide DNA sequence (5"-AACCCTA-3") corresponding to one repeat of the human C-rich strand telomeric DNA. Poly C 33-40 poly(rC) binding protein 2 Homo sapiens 129-134 16324116-4 2005 Serotonin transporter (5-HTT) mRNA also increased on days 1 and 8 after poly I:C injection in the same brain regions where IFN-alpha mRNA increased. Poly C 72-80 solute carrier family 6 member 4 Rattus norvegicus 0-21 16324116-4 2005 Serotonin transporter (5-HTT) mRNA also increased on days 1 and 8 after poly I:C injection in the same brain regions where IFN-alpha mRNA increased. Poly C 72-80 huntingtin Rattus norvegicus 25-28 15705927-6 2005 Polyinosine: polycytidylic acid (poly I:C), a TLR3 ligand, led to a 9-fold increase. Poly C 13-31 toll-like receptor 3 Mus musculus 46-50 16020515-5 2005 Many poly-C tract length differences and specific point mutations seen in these same donors but assayed 2 years earlier were still present in the new CD34+ samples. Poly C 5-11 CD34 molecule Homo sapiens 150-154 15955566-12 2005 However, a complete phosphorothioate ODN with a central CpG-motif and poly-C sequences, that did not induce IFN, readily induced IL-6 both in the presence and absence of lipofectin. Poly C 70-76 interleukin 6 Equus caballus 129-133 16123342-0 2005 Interferon-alpha as a mediator of polyinosinic:polycytidylic acid-induced type 1 diabetes. Poly C 47-65 interferon alpha Mus musculus 0-16 15967798-7 2005 Labeled AB transcripts formed specific complexes with hepatoma cell extracts that contained the poly(C)-binding proteins, iso-alphaCP1 and -alphaCP2, which have well defined roles as translation regulators. Poly C 96-103 poly(rC) binding protein 1 Homo sapiens 126-134 16321207-12 2005 The concentrations of IL-8 in the supernatant of the culture fluid of THEC cells increased along with the time of stimulation of LPS and Poly: C, ligands for TLR3 and 4, and reached to 297.33 pg/ml and 229.67 pg/ml respectively 8 hours after, 10 times and 7 times those of the control group (both P < 0.05). Poly C 137-144 C-X-C motif chemokine ligand 8 Homo sapiens 22-26 15705927-7 2005 Levels of aP2 protein were significantly increased in LPS or zymosan-treated macrophages compared with control or poly I:C-treated cells. Poly C 114-122 fatty acid binding protein 4, adipocyte Mus musculus 10-13 15789358-2 2005 Using surface plasmon resonance technology we demonstrated the capacity of the poly(A):poly(U) (pA:pU) motif to bind with high affinity to a totally synthetic Tat protein and to inhibit more efficiently the Tat/transactivation response element (TAR) RNA interaction as compared to the poly(I):poly(C) (pI:pC) motif. Poly C 293-300 tyrosine aminotransferase Homo sapiens 159-162 15789358-2 2005 Using surface plasmon resonance technology we demonstrated the capacity of the poly(A):poly(U) (pA:pU) motif to bind with high affinity to a totally synthetic Tat protein and to inhibit more efficiently the Tat/transactivation response element (TAR) RNA interaction as compared to the poly(I):poly(C) (pI:pC) motif. Poly C 293-300 tyrosine aminotransferase Homo sapiens 207-210 15048731-8 2004 The LPS and poly-I-C enhancement of bradykinin-induced contraction was inhibited by the transcriptional inhibitor actinomycin-D, dexamethasone, the proteasome inhibitor MG-132 and the c-Jun N-terminal kinase (JNK) inhibitor SP600125. Poly C 12-20 mitogen-activated protein kinase 8 Mus musculus 184-207 15780087-8 2005 Rapid IRF-1 hyperexpression was also noted following stimulation of mesangial cells with peptidoglycan, poly I:poly C, interferon-gamma? Poly C 111-117 interferon regulatory factor 1 Mus musculus 6-11 15607693-11 2005 We also found that activation of a PKR mutant by the polyinosinic acid:polycytidylic acid (poly I:C) is impaired when compared with the wild-type PKR. Poly C 71-89 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 35-38 15607693-11 2005 We also found that activation of a PKR mutant by the polyinosinic acid:polycytidylic acid (poly I:C) is impaired when compared with the wild-type PKR. Poly C 71-89 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 146-149 15507307-8 2004 When macrophages infected with isolates 3, 7, or 12 were treated with polycytidylic acid (polyI:C), IFN-alpha production was enhanced. Poly C 70-88 interferon alpha 1 Homo sapiens 100-109 15507307-8 2004 When macrophages infected with isolates 3, 7, or 12 were treated with polycytidylic acid (polyI:C), IFN-alpha production was enhanced. Poly C 90-97 interferon alpha 1 Homo sapiens 100-109 15507307-9 2004 Cells infected with isolate 3 and treated with polyI:C showed the most consistent and strongest enhancement of IFN-alpha production. Poly C 47-54 interferon alpha 1 Homo sapiens 111-120 15507307-10 2004 It was demonstrated that the relatively low concentrations of IFN-alpha produced by isolate 3 contributed to the enhanced IFN-alpha synthesis in response to polyI:C. Poly C 157-164 interferon alpha 1 Homo sapiens 62-71 15507307-10 2004 It was demonstrated that the relatively low concentrations of IFN-alpha produced by isolate 3 contributed to the enhanced IFN-alpha synthesis in response to polyI:C. Poly C 157-164 interferon alpha 1 Homo sapiens 122-131 15507307-11 2004 Isolates 7 and 12 significantly suppressed the enhanced IFN-alpha production by isolate 3 in polyI:C treated cells. Poly C 93-100 interferon alpha 1 Homo sapiens 56-65 15507307-15 2004 Furthermore, a PRRSV field isolate strongly enhance polyI:C-induced IFN-alpha production in PAM cultures and this priming effect was suppressed by other PRRSV isolates. Poly C 52-59 interferon alpha 1 Homo sapiens 68-71 15731341-6 2005 A model of alphaCP1-KH3 with poly(C)-RNA was generated by homology to a recently reported RNA-bound KH domain structure and suggests the molecular basis for oligonucleotide binding and poly(C)-RNA specificity. Poly C 29-36 poly(rC) binding protein 1 Homo sapiens 11-19 15731341-6 2005 A model of alphaCP1-KH3 with poly(C)-RNA was generated by homology to a recently reported RNA-bound KH domain structure and suggests the molecular basis for oligonucleotide binding and poly(C)-RNA specificity. Poly C 185-192 poly(rC) binding protein 1 Homo sapiens 11-19 15342370-2 2004 We show that IFN-alpha and polyinosinic:polycytidylic acid (p-I:C) synergize with the "classical" type-1-polarizing cytokine cocktail [tumor necrosis factor alpha (TNFalpha)/IL-1beta/IFNgamma], allowing for serum-free generation of fully mature type-1-polarized DCs (DC1). Poly C 40-58 tumor necrosis factor Homo sapiens 164-172 15342370-2 2004 We show that IFN-alpha and polyinosinic:polycytidylic acid (p-I:C) synergize with the "classical" type-1-polarizing cytokine cocktail [tumor necrosis factor alpha (TNFalpha)/IL-1beta/IFNgamma], allowing for serum-free generation of fully mature type-1-polarized DCs (DC1). Poly C 40-58 interleukin 1 beta Homo sapiens 174-182 15342370-2 2004 We show that IFN-alpha and polyinosinic:polycytidylic acid (p-I:C) synergize with the "classical" type-1-polarizing cytokine cocktail [tumor necrosis factor alpha (TNFalpha)/IL-1beta/IFNgamma], allowing for serum-free generation of fully mature type-1-polarized DCs (DC1). Poly C 40-58 interferon gamma Homo sapiens 183-191 15028736-5 2004 We then characterized the ATPase activity of Dbp9p with respect to cofactor specificity; the activity was found to be severely inhibited by yeast total RNA and moderately inhibited by poly(U), poly(A), and poly(C) but to be stimulated by yeast genomic DNA and salmon sperm DNA. Poly C 206-212 ATP-dependent DNA/RNA helicase Saccharomyces cerevisiae S288C 45-50 15048731-8 2004 The LPS and poly-I-C enhancement of bradykinin-induced contraction was inhibited by the transcriptional inhibitor actinomycin-D, dexamethasone, the proteasome inhibitor MG-132 and the c-Jun N-terminal kinase (JNK) inhibitor SP600125. Poly C 12-20 mitogen-activated protein kinase 8 Mus musculus 209-212 15048731-9 2004 LPS and poly-I-C induced translocation of NF-kappa B p65 to the nucleus and up-regulation of kinin B(1) and B(2) receptor mRNA. Poly C 8-16 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 42-52 15048731-9 2004 LPS and poly-I-C induced translocation of NF-kappa B p65 to the nucleus and up-regulation of kinin B(1) and B(2) receptor mRNA. Poly C 8-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 15048731-9 2004 LPS and poly-I-C induced translocation of NF-kappa B p65 to the nucleus and up-regulation of kinin B(1) and B(2) receptor mRNA. Poly C 8-16 bradykinin receptor, beta 1 Mus musculus 93-121 14585200-6 2003 Poly(I)-poly(C) induced two IFN transcripts in head kidney of Atlantic salmon. Poly C 8-15 interferon alpha 1 Homo sapiens 28-31 12590973-8 2003 Furthermore, RTG-2 cells responded to treatment with poly(I).poly(C) or to infection by infectious pancreatic necrosis virus, IPNV, by increasing eIF2alpha phosphorylation. Poly C 61-68 eukaryotic translation initiation factor 2A Danio rerio 146-155 14566081-0 2003 Poly-C specific ribonuclease activity correlates with increased concentrations of IL-6, IL-8 and sTNFR55/sTNFR75 in plasma of patients with acute pancreatitis. Poly C 0-6 interleukin 6 Homo sapiens 82-86 14566081-0 2003 Poly-C specific ribonuclease activity correlates with increased concentrations of IL-6, IL-8 and sTNFR55/sTNFR75 in plasma of patients with acute pancreatitis. Poly C 0-6 C-X-C motif chemokine ligand 8 Homo sapiens 88-92 12819017-3 2003 Virus infection or viral mimic [polyinosinic acid:polycytidylic acid (polyI:C)] treatment of human colon M-SMCs in vitro increases cell surface hyaluronan (HA), and nonactivated mononuclear leukocytes bind to virus-induced HA structures by interactions that involve the HA-binding receptor CD44. Poly C 50-68 CD44 molecule (Indian blood group) Homo sapiens 290-294 12590136-7 2003 Poly(U), poly(C), and poly(G) were also found to be 12-30-fold better inhibitors of CCR4 compared with poly(A), supporting the observation that CCR4 contains a non-poly(A)-specific binding site. Poly C 9-16 CCR4-NOT core exoribonuclease subunit CCR4 Saccharomyces cerevisiae S288C 84-88 12689664-1 2003 A converting activity was characterized in human diploid fibroblasts, which secrete 72IL-8 and 77IL-8 in treatment with IFN-beta and poly I: poly C. Poly C 141-147 C-X-C motif chemokine ligand 8 Homo sapiens 86-101 12586220-8 2003 In contrast, IL-10 was minimally induced by poly I:C alone, but it was substantially induced by poly I:C plus EtOH. Poly C 44-52 interleukin 10 Mus musculus 13-18 12586220-8 2003 In contrast, IL-10 was minimally induced by poly I:C alone, but it was substantially induced by poly I:C plus EtOH. Poly C 96-104 interleukin 10 Mus musculus 13-18 14574737-2 2003 An increase of the enzyme activity was established in the presence of FGA, concanavaline A, poly(I).poly(C) in vitro. Poly C 100-107 fibrinogen alpha chain Rattus norvegicus 70-73 12525633-5 2003 Treatment with the known IFN inducer polyinosinic acid-polycytidylic acid (poly[I]-poly[C]) resulted in an increase in zfIFN mRNA transcripts. Poly C 83-89 interferon phi 1 Danio rerio 25-28 12525633-5 2003 Treatment with the known IFN inducer polyinosinic acid-polycytidylic acid (poly[I]-poly[C]) resulted in an increase in zfIFN mRNA transcripts. Poly C 83-89 interferon phi 1 Danio rerio 119-124 12054664-3 2002 Here, we show the mAb to TLR3 suppressed poly(I):poly(C)-mediated IFN-beta production by human fibroblasts naturally expressing TLR3 on their surface. Poly C 49-56 toll like receptor 3 Homo sapiens 25-29 12401717-3 2002 We previously identified a disease-susceptibility locus in the BBDR rat, iddm4, which is associated with the development of autoimmune diabetes after treatment with polyinosinic:polycytidylic acid and an antibody that depletes ART2(+) regulatory cells. Poly C 178-196 Insulin dependent diabetes mellitus QTL 8 Rattus norvegicus 73-78 12186889-6 2002 poly(C)] and encephalomyocarditis virus were greatly enhanced by IFN-gamma pretreatment (priming) of wild-type cells or of mutant cells lacking an IFN-alpha/beta response; these include the primary induction of dsRNA-inducible mRNAs, including IFN-beta mRNA, and, to a lesser extent, the dsRNA-mediated activation of the p38 mitogen-activated protein (MAP) kinase(s). Poly C 0-7 interferon gamma Homo sapiens 65-74 12186889-6 2002 poly(C)] and encephalomyocarditis virus were greatly enhanced by IFN-gamma pretreatment (priming) of wild-type cells or of mutant cells lacking an IFN-alpha/beta response; these include the primary induction of dsRNA-inducible mRNAs, including IFN-beta mRNA, and, to a lesser extent, the dsRNA-mediated activation of the p38 mitogen-activated protein (MAP) kinase(s). Poly C 0-7 interferon alpha 1 Homo sapiens 147-156 12186889-6 2002 poly(C)] and encephalomyocarditis virus were greatly enhanced by IFN-gamma pretreatment (priming) of wild-type cells or of mutant cells lacking an IFN-alpha/beta response; these include the primary induction of dsRNA-inducible mRNAs, including IFN-beta mRNA, and, to a lesser extent, the dsRNA-mediated activation of the p38 mitogen-activated protein (MAP) kinase(s). Poly C 0-7 interferon beta 1 Homo sapiens 244-252 12186889-6 2002 poly(C)] and encephalomyocarditis virus were greatly enhanced by IFN-gamma pretreatment (priming) of wild-type cells or of mutant cells lacking an IFN-alpha/beta response; these include the primary induction of dsRNA-inducible mRNAs, including IFN-beta mRNA, and, to a lesser extent, the dsRNA-mediated activation of the p38 mitogen-activated protein (MAP) kinase(s). Poly C 0-7 mitogen-activated protein kinase 1 Homo sapiens 321-324 12011088-0 2002 Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3"-untranslated region of the androgen receptor messenger RNA. Poly C 25-32 androgen receptor Homo sapiens 119-136 12011088-9 2002 Poly(C)-binding protein-1 and -2 (CP1 and CP2), previously implicated in the control of mRNA turnover and translation, also bound avidly to the UC-rich region. Poly C 0-7 ceruloplasmin Homo sapiens 42-45 12054664-3 2002 Here, we show the mAb to TLR3 suppressed poly(I):poly(C)-mediated IFN-beta production by human fibroblasts naturally expressing TLR3 on their surface. Poly C 49-56 interferon beta 1 Homo sapiens 66-74 12054664-3 2002 Here, we show the mAb to TLR3 suppressed poly(I):poly(C)-mediated IFN-beta production by human fibroblasts naturally expressing TLR3 on their surface. Poly C 49-56 toll like receptor 3 Homo sapiens 128-132 11958862-5 2002 Hypoxia-inducible expression of poly(C)-binding protein 1 was mediated by p38 mitogen-activated protein kinase, while hypoxia-reducible expression of poly(C)-binding protein 2 was mediated by protein kinase C. Immunostaining showed that poly(C)-binding protein 1, but not poly(C)-binding protein 2, expression was increased in the ischemic boundary zone (penumbra) of the frontal cortex after 90 min of ischemia, and persisted for at least 72 h after reperfusion. Poly C 32-38 mitogen activated protein kinase 14 Rattus norvegicus 74-77 12096926-7 2002 When melanocytes and melanoma cells were treated with a potent IFN inducer, polyinosinic:polycytidylic acid (poly I:C), the mRNA expression of both IFN-alpha and IFN-beta was significantly upregulated. Poly C 89-107 interferon alpha 1 Homo sapiens 63-66 12096926-7 2002 When melanocytes and melanoma cells were treated with a potent IFN inducer, polyinosinic:polycytidylic acid (poly I:C), the mRNA expression of both IFN-alpha and IFN-beta was significantly upregulated. Poly C 89-107 interferon alpha 1 Homo sapiens 148-157 12096926-7 2002 When melanocytes and melanoma cells were treated with a potent IFN inducer, polyinosinic:polycytidylic acid (poly I:C), the mRNA expression of both IFN-alpha and IFN-beta was significantly upregulated. Poly C 89-107 interferon beta 1 Homo sapiens 162-170 11958862-5 2002 Hypoxia-inducible expression of poly(C)-binding protein 1 was mediated by p38 mitogen-activated protein kinase, while hypoxia-reducible expression of poly(C)-binding protein 2 was mediated by protein kinase C. Immunostaining showed that poly(C)-binding protein 1, but not poly(C)-binding protein 2, expression was increased in the ischemic boundary zone (penumbra) of the frontal cortex after 90 min of ischemia, and persisted for at least 72 h after reperfusion. Poly C 32-39 mitogen activated protein kinase 14 Rattus norvegicus 74-77 11433018-4 2001 In vitro, Nhp2p interacts with high affinity with RNAs containing irregular stem-loop structures but shows weak affinity for poly(A), poly(C) or for double-stranded RNAs. Poly C 134-140 snoRNA-binding protein NHP2 Saccharomyces cerevisiae S288C 10-15 11742128-2 2002 Oligocytidylic acids, ranging from dinucleotides to heptanucleotides, were obtained by RNase A digestion of poly(C). Poly C 108-115 ribonuclease pancreatic Bos taurus 87-94 11722649-7 2001 RA + PIC-treated rats had significantly higher levels of interleukin (IL)-10, IL-12, and signal transducer and activator of transcription-1 (STAT-1) mRNA (P < 0.05), and STAT-1 protein (P < 0.02). Poly C 5-8 signal transducer and activator of transcription 1 Rattus norvegicus 89-139 11722649-7 2001 RA + PIC-treated rats had significantly higher levels of interleukin (IL)-10, IL-12, and signal transducer and activator of transcription-1 (STAT-1) mRNA (P < 0.05), and STAT-1 protein (P < 0.02). Poly C 5-8 signal transducer and activator of transcription 1 Rattus norvegicus 141-147 11722649-7 2001 RA + PIC-treated rats had significantly higher levels of interleukin (IL)-10, IL-12, and signal transducer and activator of transcription-1 (STAT-1) mRNA (P < 0.05), and STAT-1 protein (P < 0.02). Poly C 5-8 signal transducer and activator of transcription 1 Rattus norvegicus 173-179 11522298-4 2001 BLOX-1-CHO adhesion to FN-coated plates can also be suppressed by scavenger receptor ligands, such as OxLDL, polyinosinic acid (poly I), and dextran sulfate, but not by native LDL, acetylated LDL, polycytidylic acid (poly C), or chondroitin sulfate. Poly C 197-215 oxidized low density lipoprotein receptor 1 Bos taurus 0-6 11522298-4 2001 BLOX-1-CHO adhesion to FN-coated plates can also be suppressed by scavenger receptor ligands, such as OxLDL, polyinosinic acid (poly I), and dextran sulfate, but not by native LDL, acetylated LDL, polycytidylic acid (poly C), or chondroitin sulfate. Poly C 197-215 fibronectin 1 Bos taurus 23-25 11522298-4 2001 BLOX-1-CHO adhesion to FN-coated plates can also be suppressed by scavenger receptor ligands, such as OxLDL, polyinosinic acid (poly I), and dextran sulfate, but not by native LDL, acetylated LDL, polycytidylic acid (poly C), or chondroitin sulfate. Poly C 217-223 oxidized low density lipoprotein receptor 1 Bos taurus 0-6 11522298-4 2001 BLOX-1-CHO adhesion to FN-coated plates can also be suppressed by scavenger receptor ligands, such as OxLDL, polyinosinic acid (poly I), and dextran sulfate, but not by native LDL, acetylated LDL, polycytidylic acid (poly C), or chondroitin sulfate. Poly C 217-223 fibronectin 1 Bos taurus 23-25 12836375-7 2001 Poly(C) and poly(A) was retained in the SPG column at low temperature, though poly(G) passed by SPG column without interaction. Poly C 0-7 SPG16 Homo sapiens 40-43 11410650-9 2001 We also demonstrate that poly(A) is a better competitor than poly(G) or poly(C) of the Pop2p nuclease activity. Poly C 72-79 CCR4-NOT core DEDD family RNase subunit POP2 Saccharomyces cerevisiae S288C 87-92 10899117-2 2000 dsRNA [polyinosinic:polycytidylic acid (poly IC)]-stimulated inducible nitric oxide synthase, interleukin (IL)-1alpha and IL-1beta mRNA expression, nitrite formation and IL-1 release are attenuated in RAW264.7 cells stably expressing dominant negative (dn) mutants of PKR. Poly C 20-38 interleukin 1 alpha Mus musculus 94-117 10891498-6 2000 By generating cell lines that inducibly express either wild-type or mutated forms of MCG10 and MCG10as, we found that MCG10 and MCG10as can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. In addition, we found that MCG10 and MCG10as, through their KH domains, can bind poly(C) and that their RNA-binding activity is necessary for inducing apoptosis and cell cycle arrest. Poly C 304-310 poly(rC) binding protein 4 Homo sapiens 85-90 10891498-6 2000 By generating cell lines that inducibly express either wild-type or mutated forms of MCG10 and MCG10as, we found that MCG10 and MCG10as can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. In addition, we found that MCG10 and MCG10as, through their KH domains, can bind poly(C) and that their RNA-binding activity is necessary for inducing apoptosis and cell cycle arrest. Poly C 304-310 poly(rC) binding protein 4 Homo sapiens 95-100 10891498-6 2000 By generating cell lines that inducibly express either wild-type or mutated forms of MCG10 and MCG10as, we found that MCG10 and MCG10as can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. In addition, we found that MCG10 and MCG10as, through their KH domains, can bind poly(C) and that their RNA-binding activity is necessary for inducing apoptosis and cell cycle arrest. Poly C 304-310 poly(rC) binding protein 4 Homo sapiens 95-100 10891498-6 2000 By generating cell lines that inducibly express either wild-type or mutated forms of MCG10 and MCG10as, we found that MCG10 and MCG10as can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. In addition, we found that MCG10 and MCG10as, through their KH domains, can bind poly(C) and that their RNA-binding activity is necessary for inducing apoptosis and cell cycle arrest. Poly C 304-310 poly(rC) binding protein 4 Homo sapiens 95-100 10891498-6 2000 By generating cell lines that inducibly express either wild-type or mutated forms of MCG10 and MCG10as, we found that MCG10 and MCG10as can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. In addition, we found that MCG10 and MCG10as, through their KH domains, can bind poly(C) and that their RNA-binding activity is necessary for inducing apoptosis and cell cycle arrest. Poly C 304-310 poly(rC) binding protein 4 Homo sapiens 95-100 10891498-6 2000 By generating cell lines that inducibly express either wild-type or mutated forms of MCG10 and MCG10as, we found that MCG10 and MCG10as can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. In addition, we found that MCG10 and MCG10as, through their KH domains, can bind poly(C) and that their RNA-binding activity is necessary for inducing apoptosis and cell cycle arrest. Poly C 304-310 poly(rC) binding protein 4 Homo sapiens 95-100 10891498-7 2000 Furthermore, we found that the level of the poly(C) binding MCG10 protein is increased in cells treated with the DNA-damaging agent camptothecin in a p53-dependent manner. Poly C 44-51 poly(rC) binding protein 4 Homo sapiens 60-65 10891498-7 2000 Furthermore, we found that the level of the poly(C) binding MCG10 protein is increased in cells treated with the DNA-damaging agent camptothecin in a p53-dependent manner. Poly C 44-51 tumor protein p53 Homo sapiens 150-153 10899117-2 2000 dsRNA [polyinosinic:polycytidylic acid (poly IC)]-stimulated inducible nitric oxide synthase, interleukin (IL)-1alpha and IL-1beta mRNA expression, nitrite formation and IL-1 release are attenuated in RAW264.7 cells stably expressing dominant negative (dn) mutants of PKR. Poly C 20-38 interleukin 1 beta Mus musculus 122-130 10899117-2 2000 dsRNA [polyinosinic:polycytidylic acid (poly IC)]-stimulated inducible nitric oxide synthase, interleukin (IL)-1alpha and IL-1beta mRNA expression, nitrite formation and IL-1 release are attenuated in RAW264.7 cells stably expressing dominant negative (dn) mutants of PKR. Poly C 20-38 eukaryotic translation initiation factor 2-alpha kinase 2 Mus musculus 268-271 10713453-5 2000 As the hnRNP K in vertebrates the M(r) 55 000 Drosophila Hrb57A/Q18 protein strongly binds to poly(C) in vitro and is ubiquitously present in nuclei active in transcription. Poly C 94-101 Heterogeneous nuclear ribonucleoprotein K Drosophila melanogaster 7-14 10837825-10 2000 Point mutations in the NF-H binding site which prevented formation of the poly(C)-sensitive complex also stabilized the fusion mRNA. Poly C 74-81 neurofilament heavy chain Rattus norvegicus 23-27 10713453-5 2000 As the hnRNP K in vertebrates the M(r) 55 000 Drosophila Hrb57A/Q18 protein strongly binds to poly(C) in vitro and is ubiquitously present in nuclei active in transcription. Poly C 94-101 Heterogeneous nuclear ribonucleoprotein K Drosophila melanogaster 57-63 10713453-5 2000 As the hnRNP K in vertebrates the M(r) 55 000 Drosophila Hrb57A/Q18 protein strongly binds to poly(C) in vitro and is ubiquitously present in nuclei active in transcription. Poly C 94-101 Heterogeneous nuclear ribonucleoprotein K Drosophila melanogaster 64-67 10220316-6 1999 T45G RNase A, which catalyzes the processive cleavage of poly(A) but the distributive cleavage of poly(cytidylic acid) [poly(C)], has the same preference. Poly C 98-118 ribonuclease pancreatic Bos taurus 5-12 10704250-5 2000 Poly(I).poly(C) induces ISG12 in a cell line-dependent manner, whereas none of the other cytokines tested elicited a response. Poly C 8-15 interferon alpha inducible protein 27 Homo sapiens 24-29 10687957-4 2000 Lactoferrin exerted RNase activity on poly C with an activity of 2.15 U/mg. Poly C 38-44 lactotransferrin Bos taurus 0-11 10632727-6 2000 Removing either one of the terminal disulfide bonds liberates a similar number of residues and has a similar effect on conformational stability, decreasing the midpoint of the thermal transition by almost 40 degrees C. The disulfide variants catalyze the cleavage of poly(cytidylic acid) with values of kcat/Km that are 2- to 40-fold less than that of wild-type RNase A. Poly C 267-287 ribonuclease pancreatic Bos taurus 362-369 10553506-0 1999 A poly(C) repeat polymorphism in the promoter of the IL-10 gene in NZB mice. Poly C 2-8 interleukin 10 Mus musculus 53-58 10455157-3 1999 The two major cytoplasmic poly(C)-binding proteins in mammalian cells, alphaCP-1 and alphaCP-2, are implicated in a spectrum of post-transcriptional controls. Poly C 26-33 poly(rC) binding protein 1 Homo sapiens 71-80 10455157-3 1999 The two major cytoplasmic poly(C)-binding proteins in mammalian cells, alphaCP-1 and alphaCP-2, are implicated in a spectrum of post-transcriptional controls. Poly C 26-33 poly(rC) binding protein 2 Homo sapiens 85-94 10445881-9 1999 A specific poly(C)-sensitive complex formed on the TAPA-1 and coxII 3" UTRs consistent with the binding of aCP1. Poly C 11-18 CD81 molecule Homo sapiens 51-57 10445881-9 1999 A specific poly(C)-sensitive complex formed on the TAPA-1 and coxII 3" UTRs consistent with the binding of aCP1. Poly C 11-18 acid phosphatase 1 Homo sapiens 107-111 10400313-5 1999 In the presence of poly(I):poly(C), the PKR activator, we detected both an increased phosphorylation of eIF-2alpha and an increment in the autophosphorylation of PKR. Poly C 27-34 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 40-43 10400313-5 1999 In the presence of poly(I):poly(C), the PKR activator, we detected both an increased phosphorylation of eIF-2alpha and an increment in the autophosphorylation of PKR. Poly C 27-34 eukaryotic translation initiation factor 2A Homo sapiens 104-114 10400313-5 1999 In the presence of poly(I):poly(C), the PKR activator, we detected both an increased phosphorylation of eIF-2alpha and an increment in the autophosphorylation of PKR. Poly C 27-34 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 162-165 10329716-7 1999 In vitro, PKCdelta binds K protein via the highly interactive KI domain, an interaction that is blocked by poly(C) RNA. Poly C 107-114 protein kinase C delta Homo sapiens 10-18 11543371-4 1999 Specifically, at a constant [poly(C)], values of d[G2p]/dt typically increased with [G]o with a parabolic upward curvature. Poly C 29-36 crystallin gamma E, pseudogene Homo sapiens 51-54 11543371-5 1999 At a constant [G]o, values of d[G2p]/dt increase with [poly(C)], but level off at the higher poly(C) concentrations. Poly C 55-62 crystallin gamma E, pseudogene Homo sapiens 32-35 11543371-5 1999 At a constant [G]o, values of d[G2p]/dt increase with [poly(C)], but level off at the higher poly(C) concentrations. Poly C 93-100 crystallin gamma E, pseudogene Homo sapiens 32-35 10504400-11 1999 On the contrary, the activity of the RNase A oligomers, from dimer to pentamer, on yeast RNA and poly(C) (Kunitz assay) is lower than that of monomeric RNase A. Poly C 97-103 ribonuclease pancreatic Bos taurus 37-44 10432301-1 1999 Eukaryotic translation initiation factor 2alpha (eIF-2alpha), a target molecule of the interferon-inducible double-stranded-RNA-dependent protein kinase (PKR), was cleaved in apoptotic Saos-2 cells on treatment with poly(I).poly(C) or tumour necrosis factor alpha. Poly C 224-230 eukaryotic translation initiation factor 2A Homo sapiens 0-47 10432301-1 1999 Eukaryotic translation initiation factor 2alpha (eIF-2alpha), a target molecule of the interferon-inducible double-stranded-RNA-dependent protein kinase (PKR), was cleaved in apoptotic Saos-2 cells on treatment with poly(I).poly(C) or tumour necrosis factor alpha. Poly C 224-230 eukaryotic translation initiation factor 2A Homo sapiens 49-59 10432301-1 1999 Eukaryotic translation initiation factor 2alpha (eIF-2alpha), a target molecule of the interferon-inducible double-stranded-RNA-dependent protein kinase (PKR), was cleaved in apoptotic Saos-2 cells on treatment with poly(I).poly(C) or tumour necrosis factor alpha. Poly C 224-230 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 154-157 10220316-6 1999 T45G RNase A, which catalyzes the processive cleavage of poly(A) but the distributive cleavage of poly(cytidylic acid) [poly(C)], has the same preference. Poly C 120-127 ribonuclease pancreatic Bos taurus 5-12 9682215-12 1998 These changes are within or in close proximity to a CCTG sequence and a poly(C) tract, both of which are shown in other systems to be mutation hotspots. Poly C 72-79 chaperonin containing TCP1 subunit 3 Homo sapiens 52-56 10068686-0 1999 Identification of the poly(C) binding protein in the complex associated with the 3" untranslated region of erythropoietin messenger RNA. Poly C 22-29 erythropoietin Homo sapiens 107-121 9920723-0 1999 Stimulation side-dependent asymmetrical secretion of poly I:poly C-induced interferon-beta from polarized epithelial cell lines. Poly C 60-66 interferon beta 1 Homo sapiens 75-90 9920723-1 1999 Mode of secretion of poly I:poly C-induced IFN was examined using epithelial cell lines in a bicameral culture system. Poly C 28-34 interferon alpha 1 Homo sapiens 43-46 9724524-6 1998 Wild-type RNase A and the K66A, K7A/R10A, and K7A/R10A/K66A variants were evaluated as catalysts for the cleavage of poly(cytidylic acid) [poly(C)] and for their abilities to bind to single-stranded DNA, a substrate analogue. Poly C 117-137 ribonuclease pancreatic Bos taurus 10-17 9724524-6 1998 Wild-type RNase A and the K66A, K7A/R10A, and K7A/R10A/K66A variants were evaluated as catalysts for the cleavage of poly(cytidylic acid) [poly(C)] and for their abilities to bind to single-stranded DNA, a substrate analogue. Poly C 139-146 ribonuclease pancreatic Bos taurus 10-17 9724524-8 1998 The kcat/Km values for poly(C) cleavage by the K66A, K7A/R10A, and K7A/R10A/K66A variants were 3-fold, 60-fold, and 300-fold lower, respectively, than that of wild-type RNase A. Poly C 23-30 ribonuclease pancreatic Bos taurus 169-176 9675022-6 1998 On synthetic polyribonucleotide substrates, the RNase activity of Zn alpha 2gp is specific for pyrimidine residues [poly(C) and poly(U) equally] and cleaves only single-stranded RNA. Poly C 116-123 alpha-2-glycoprotein 1, zinc-binding Homo sapiens 66-78 9629309-7 1998 Poly (i)-poly (c)-induced IFN-alpha production by monocytes was inhibited by glucocorticoids in the AIDS-C group and controls (approx. Poly C 9-17 interferon alpha 1 Homo sapiens 26-35 9920723-3 1999 When poly I:poly C was applied to the upper compartment, IFN was secreted predominantly from the apical membrane. Poly C 12-18 interferon alpha 1 Homo sapiens 57-60 9920723-4 1999 Inversely, poly I:poly C applied to the lower compartment caused preferential IFN secretion from the basolateral membrane. Poly C 18-24 interferon alpha 1 Homo sapiens 78-81 9756612-2 1998 However, the dose of poly I:poly C required for efficient IFN induction is so high as occasionally to be cytotoxic. Poly C 28-34 interferon alpha 1 Homo sapiens 58-61 9756612-3 1998 In this work, we examined the IFN-inducibility of poly I:poly C complexed with several cationic reagents in mouse fibroblast L cells and found that Lipofectin and LipofectACE can induce the production of a substantial amount of type I IFNs (mostly beta-type) even at a two-order lower dose compared with poly I:poly C alone. Poly C 57-63 interferon alpha 1 Homo sapiens 30-33 9756612-3 1998 In this work, we examined the IFN-inducibility of poly I:poly C complexed with several cationic reagents in mouse fibroblast L cells and found that Lipofectin and LipofectACE can induce the production of a substantial amount of type I IFNs (mostly beta-type) even at a two-order lower dose compared with poly I:poly C alone. Poly C 311-317 interferon alpha 1 Homo sapiens 30-33 9624140-5 1998 FLAG-Fmrp exhibited selectivity for binding poly(G) > poly(U) >> poly(C) or poly(A). Poly C 74-80 fragile X messenger ribonucleoprotein 1 Homo sapiens 5-9 9682215-14 1998 The present observations suggest that the short SP-B sequence containing the CCTG motif and the poly(C) tract is a mutation hotspot. Poly C 96-103 surfactant protein B Homo sapiens 48-52 21528262-5 1997 The ability of the transcript to activate PKR was sensitive to ribonuclease V1 and was abolished by the addition of high concentrations of poly(I).poly(C). Poly C 147-154 eukaryotic translation initiation factor 2-alpha kinase 2 Mus musculus 42-45 9388488-3 1997 Using human monocyte-derived macrophages as a model of brain microglia, physiological levels of apolipoprotein-E were found to stimulate nitric oxide (NO) production in polyinosinic:polycytidylic acid (poly I:C) primed cells. Poly C 182-200 apolipoprotein E Homo sapiens 96-112 9294150-6 1997 Inhibition of RNase L with a dominant negative mutant suppressed poly (I).poly (C)-induced apoptosis in interferon-primed fibroblasts. Poly C 74-82 ribonuclease L Homo sapiens 14-21 9287326-8 1997 A UV cross-linking assay also indicated poly(U)- and poly(C)-stimulated labeling of rSUG1 with [alpha-32P]ATP. Poly C 53-60 proteasome 26S subunit, ATPase 5 Rattus norvegicus 84-89 22358527-5 1997 The production of interferon-beta (IFN-beta) by MG-63 cells super-induced by Poly (I): Poly (C) was shown to decrease in a dose dependent manner upon the addition of 0.01-10 mug/ml of cortisol or noradrenaline (NA). Poly C 87-95 interferon beta 1 Homo sapiens 18-33 9234743-3 1997 One of the protein activities in this multiprotein complex is a poly(C)-binding activity which consists of two proteins, alphaCP1 and alphaCP2. Poly C 64-71 poly(rC) binding protein 1 Homo sapiens 121-129 9234743-3 1997 One of the protein activities in this multiprotein complex is a poly(C)-binding activity which consists of two proteins, alphaCP1 and alphaCP2. Poly C 64-71 poly(rC) binding protein 2 Homo sapiens 134-142 22358527-5 1997 The production of interferon-beta (IFN-beta) by MG-63 cells super-induced by Poly (I): Poly (C) was shown to decrease in a dose dependent manner upon the addition of 0.01-10 mug/ml of cortisol or noradrenaline (NA). Poly C 87-95 interferon beta 1 Homo sapiens 35-43 9264143-7 1997 After poly(I):poly(C) stimulation, monocytes from AIDS-GR produce much more IFN alpha than other AIDS patients. Poly C 14-21 interferon alpha 1 Homo sapiens 76-85 8871564-1 1996 The murine poly(C)-binding protein (mCBP) was previously shown to belong to the group of K-homology (KH) proteins by virtue of its homology to hnRNP-K. Poly C 11-18 CREB binding protein Mus musculus 36-40 8937426-2 1996 Previous studies have suggested that LPS- or polyIC-induced downregulation of P450 was due to endogenously released inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1, interleukin-6, and interferons (IFNs). Poly C 45-51 tumor necrosis factor Rattus norvegicus 147-174 8937426-2 1996 Previous studies have suggested that LPS- or polyIC-induced downregulation of P450 was due to endogenously released inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1, interleukin-6, and interferons (IFNs). Poly C 45-51 tumor necrosis factor Rattus norvegicus 176-185 8937426-2 1996 Previous studies have suggested that LPS- or polyIC-induced downregulation of P450 was due to endogenously released inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1, interleukin-6, and interferons (IFNs). Poly C 45-51 interleukin 6 Rattus norvegicus 203-216 8871564-1 1996 The murine poly(C)-binding protein (mCBP) was previously shown to belong to the group of K-homology (KH) proteins by virtue of its homology to hnRNP-K. Poly C 11-18 heterogeneous nuclear ribonucleoprotein K Mus musculus 143-150 8814275-3 1996 Furthermore, IgM-/- mice showed increased natural killer (NK) activity upon exposure to either lymphocytic choriomeningitis virus (LCMV) or to poly(I).poly(C), while NK activity in untreated IgM-/- mice was within normal ranges. Poly C 151-157 immunoglobulin heavy constant mu Mus musculus 13-16 8811006-4 1996 Poly(U) and poly(C) were better than poly(A) at stimulating the NTPase activities, in contrast to other flaviviral NTPases. Poly C 12-19 inosine triphosphatase Homo sapiens 64-70 8760418-3 1996 cDNA cloning and sequencing of the genomes of ERV-1 and ERV-2 between the poly(C) and poly(A) tracts showed that the serotypes are heterogeneous. Poly C 74-80 growth factor, augmenter of liver regeneration Homo sapiens 46-51 8844858-6 1996 The free energies with which Y97F, Y97A, and Y97G RNase A bind to the rate-limiting transition state during the cleavage of poly(cytidylic acid) are diminished by 0.74, 3.3, and 3.8 kcal/mol, respectively. Poly C 124-144 ribonuclease pancreatic Bos taurus 50-57 7556077-3 1995 One or more of the proteins within this alpha-complex contain strong polycytosine [poly(C)] binding (alpha PCB) activity. Poly C 83-90 pyruvate carboxylase Homo sapiens 107-110 7589141-5 1995 Taken together, these data suggest that poly I:C is a Th1-inducing agent whose activity is mediated by its ability to stimulate the production of IFN-alpha and IL-12 by monocytes. Poly C 40-48 negative elongation factor complex member C/D Homo sapiens 54-57 7589141-5 1995 Taken together, these data suggest that poly I:C is a Th1-inducing agent whose activity is mediated by its ability to stimulate the production of IFN-alpha and IL-12 by monocytes. Poly C 40-48 interferon alpha 1 Homo sapiens 146-155 7556162-0 1995 Activation of the double-stranded-RNA-activated protein kinase and induction of vascular cell adhesion molecule-1 by poly (I).poly (C) in endothelial cells. Poly C 126-134 vascular cell adhesion molecule 1 Homo sapiens 80-113 7556162-8 1995 Poly (I).poly (C) induces VCAM-1 mRNA levels that are dramatically higher and sustained longer than levels induced by IL-1 beta. Poly C 9-17 vascular cell adhesion molecule 1 Homo sapiens 26-32 7556162-9 1995 Although phosphorylation of eIF2 alpha interferes with protein translation, sufficient VCAM-1 mRNA translation occurs in response to poly (I).poly (C) to yield VCAM-1 protein levels that are similar to levels that are induced by IL-1 beta. Poly C 142-150 vascular cell adhesion molecule 1 Homo sapiens 87-93 7556162-9 1995 Although phosphorylation of eIF2 alpha interferes with protein translation, sufficient VCAM-1 mRNA translation occurs in response to poly (I).poly (C) to yield VCAM-1 protein levels that are similar to levels that are induced by IL-1 beta. Poly C 142-150 vascular cell adhesion molecule 1 Homo sapiens 160-166 7556162-10 1995 This suggests that the higher, sustained VCAM-1 mRNA levels that occur in response to incubation with poly (I).poly (C) compensate for the partial translational block resulting from increased eIF2 alpha phosphorylation. Poly C 111-118 vascular cell adhesion molecule 1 Homo sapiens 41-47 7556162-10 1995 This suggests that the higher, sustained VCAM-1 mRNA levels that occur in response to incubation with poly (I).poly (C) compensate for the partial translational block resulting from increased eIF2 alpha phosphorylation. Poly C 111-118 eukaryotic translation initiation factor 2A Homo sapiens 192-202 7749068-5 1995 IFN-alpha and poly(I).poly(C) elicited small, transient gamma 2 responses in a few of the non-lymphoid cell lines, whereas none of the other six cytokines tested elicited a response. Poly C 22-29 interferon alpha 1 Homo sapiens 0-9 7749068-5 1995 IFN-alpha and poly(I).poly(C) elicited small, transient gamma 2 responses in a few of the non-lymphoid cell lines, whereas none of the other six cytokines tested elicited a response. Poly C 22-29 tryptophanyl-tRNA synthetase 1 Homo sapiens 56-63 7969187-3 1994 GM-CSF and IFN-beta genes were expressed in response to PMA/A23187, poly(I):poly(C), IL-1 alpha, forskolin, or LPS stimulation in differentiated P19 cells, whereas IL-3 and IL-4 genes were not expressed. Poly C 76-83 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 0-6 7969187-3 1994 GM-CSF and IFN-beta genes were expressed in response to PMA/A23187, poly(I):poly(C), IL-1 alpha, forskolin, or LPS stimulation in differentiated P19 cells, whereas IL-3 and IL-4 genes were not expressed. Poly C 76-83 interferon beta 1, fibroblast Mus musculus 11-19 8069921-3 1994 LPS synergizes with low doses of IL-2, gamma interferon, poly(I).poly(C) 12U. Poly C 65-72 interleukin 2 Mus musculus 33-37 1602741-10 1992 SMC treated with poly(I):poly(C) or Newcastle Disease virus elaborated biologically active IFN-beta as well. Poly C 25-32 interferon beta 1 Homo sapiens 91-99 7908289-6 1994 This fragment of the 3"-untranslated region of TH mRNA is rich in pyrimidine nucleotides, and the binding of cytoplasmic protein to this fragment was reduced by competition with other polypyrimidine sequences including poly(C) but not poly(U) polymers. Poly C 219-226 tyrosine hydroxylase Rattus norvegicus 47-49 7507969-9 1994 Polyinosinic acid:polycytidylic acid induced significantly higher amounts of IFN but lower levels of TNF and IL-6 than imiquimod. Poly C 18-36 tumor necrosis factor Mus musculus 101-104 7507969-9 1994 Polyinosinic acid:polycytidylic acid induced significantly higher amounts of IFN but lower levels of TNF and IL-6 than imiquimod. Poly C 18-36 interleukin 6 Mus musculus 109-113 7893828-5 1994 In the present work, PKR immobilized either by immunoprecipitation or by affinity precipitation on Agpoly(I) poly(C) was found to autophosphorylate in a dsRNA-independent manner when incubated in the presence of a detergent lysis buffer and ATP. Poly C 109-116 eukaryotic translation initiation factor 2-alpha kinase 2 Mus musculus 21-24 8402903-3 1993 IRF-1-deficient fibroblasts lacked the normally observed type I IFN induction by poly(I):poly(C), while they induced type I IFN to similar levels as the wild type following Newcastle disease virus (NDV) infection. Poly C 89-96 interferon regulatory factor 1 Mus musculus 0-5 8407977-4 1993 The enzyme displayed only ATPase and deoxy-ATPase activity that was stimulated preferentially by poly(C). Poly C 97-104 dynein axonemal heavy chain 8 Homo sapiens 26-32 8407977-4 1993 The enzyme displayed only ATPase and deoxy-ATPase activity that was stimulated preferentially by poly(C). Poly C 97-104 dynein axonemal heavy chain 8 Homo sapiens 43-49 7506512-4 1993 Non-viral inducers, such as poly(rl).poly(rC), induce exclusively IFN-beta whereas viruses such as Sendai and Newcastle Disease Virus (NDV) induce mixtures of IFN-alpha subtypes and IFN-beta. Poly C 37-45 interferon alpha 1 Homo sapiens 66-69 7905506-4 1993 Treatment of HeLa cells with poly(I):poly(C) stimulated PKR autophosphorylation in vivo. Poly C 37-44 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 56-59 7683591-4 1993 Polyinosinic acid (poly I), a known scavenger receptor ligand, significantly induced the expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin on human umbilical vein endothelial cells when compared with polycytidylic acid (poly C), a structurally related compound to poly I, which does not bind to the scavenger receptor. Poly C 266-284 intercellular adhesion molecule 1 Homo sapiens 103-136 7683591-4 1993 Polyinosinic acid (poly I), a known scavenger receptor ligand, significantly induced the expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin on human umbilical vein endothelial cells when compared with polycytidylic acid (poly C), a structurally related compound to poly I, which does not bind to the scavenger receptor. Poly C 286-292 intercellular adhesion molecule 1 Homo sapiens 103-136 1590774-5 1992 RNA blotting analysis demonstrates that interferon-alpha (IFN-alpha) and its inducers, i.e. poly(I).poly(C), bacterial lipopolysaccharide (LPS) and tilorone (2,7-bis-[2-(diethylamino)ethoxy]fluoren-9-one), increase the expression of XD mRNA in liver. Poly C 100-106 interferon alpha Mus musculus 40-56 1590774-5 1992 RNA blotting analysis demonstrates that interferon-alpha (IFN-alpha) and its inducers, i.e. poly(I).poly(C), bacterial lipopolysaccharide (LPS) and tilorone (2,7-bis-[2-(diethylamino)ethoxy]fluoren-9-one), increase the expression of XD mRNA in liver. Poly C 100-106 interferon alpha Mus musculus 58-67 1940796-4 1991 Injection of mice with polyinosinic acid.polycytidylic acid (poly I.C), an inducer of macrophage IFN-alpha production, also suppresses the anti-IgD antibody-induced IgE response and stimulates the IgG2a response; these effects are blocked by a sheep antibody that neutralizes mouse IFN-alpha/beta. Poly C 41-59 interferon alpha Mus musculus 97-106 1379284-3 1992 Coculture of M phi with IFN-gamma and polyinosinic-polycytidylic acid [poly(I):poly(C)] resulted in the reduction of Ia expression in comparison with those cultured without poly(I):poly(C). Poly C 79-86 interferon gamma Homo sapiens 24-33 1379284-3 1992 Coculture of M phi with IFN-gamma and polyinosinic-polycytidylic acid [poly(I):poly(C)] resulted in the reduction of Ia expression in comparison with those cultured without poly(I):poly(C). Poly C 79-85 interferon gamma Homo sapiens 24-33 1379284-4 1992 Pretreatment of M phi with poly(I):poly(C) or a bacterial lipopolysaccharide (LPS), which is also a potent IFN inducer, in vitro or in vivo, before being exposed to IFN-gamma was also effective in suppressing the Ia expression. Poly C 35-42 interferon alpha 1 Homo sapiens 107-110 1762062-6 1991 Although oxygen exposure per se decreased the total level of lung cytochrome P-450, poly I: poly C per se induced a deeper decrease to levels similar in air- or oxygen-exposed rats. Poly C 92-98 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 66-90 1940796-4 1991 Injection of mice with polyinosinic acid.polycytidylic acid (poly I.C), an inducer of macrophage IFN-alpha production, also suppresses the anti-IgD antibody-induced IgE response and stimulates the IgG2a response; these effects are blocked by a sheep antibody that neutralizes mouse IFN-alpha/beta. Poly C 41-59 immunoglobulin heavy variable V1-9 Mus musculus 197-202 1940796-4 1991 Injection of mice with polyinosinic acid.polycytidylic acid (poly I.C), an inducer of macrophage IFN-alpha production, also suppresses the anti-IgD antibody-induced IgE response and stimulates the IgG2a response; these effects are blocked by a sheep antibody that neutralizes mouse IFN-alpha/beta. Poly C 41-59 interferon alpha Mus musculus 282-291 1940796-4 1991 Injection of mice with polyinosinic acid.polycytidylic acid (poly I.C), an inducer of macrophage IFN-alpha production, also suppresses the anti-IgD antibody-induced IgE response and stimulates the IgG2a response; these effects are blocked by a sheep antibody that neutralizes mouse IFN-alpha/beta. Poly C 61-69 interferon alpha Mus musculus 97-106 1940796-4 1991 Injection of mice with polyinosinic acid.polycytidylic acid (poly I.C), an inducer of macrophage IFN-alpha production, also suppresses the anti-IgD antibody-induced IgE response and stimulates the IgG2a response; these effects are blocked by a sheep antibody that neutralizes mouse IFN-alpha/beta. Poly C 61-69 immunoglobulin heavy variable V1-9 Mus musculus 197-202 1940796-4 1991 Injection of mice with polyinosinic acid.polycytidylic acid (poly I.C), an inducer of macrophage IFN-alpha production, also suppresses the anti-IgD antibody-induced IgE response and stimulates the IgG2a response; these effects are blocked by a sheep antibody that neutralizes mouse IFN-alpha/beta. Poly C 61-69 interferon alpha Mus musculus 282-291 1931812-7 1991 Immunization of mice with Brucella abortus or poly (I).poly (C) resulted in induction of Ly-6A/E expression by virtually all B and T cells, whereas injection of G alpha M delta led to peak induction of Ly-6A/E by approximately 50% of both B and T cells. Poly C 55-63 lymphocyte antigen 6 complex, locus A Mus musculus 89-96 1681618-4 1991 A single major virus-specific polypeptide of Mr = 25,000 (p25) bound to the poly(rI).poly(rC)-Sepharose. Poly C 85-93 tubulin polymerization promoting protein Homo sapiens 58-61 1904722-1 1991 Kinetic parameters kcat and KM were measured for cleavage of poly I, poly A, poly U, poly C and poly I poly C by guanyl-specific RNases Sa, Pb1 and T1 and compared with that of guanyl-preferential RNase Bi. Poly C 103-109 polybromo 1 Homo sapiens 140-143 1944260-9 1991 The inhibition degree of bovine liver tyrosyl-tRNA synthetase decreased in the order: poly (G) greater than poly (I) greater than poly (I).poly (C) greater than poly (G).poly (C) greater than poly (C) greater than poly (A). Poly C 139-146 tyrosyl-tRNA synthetase 1 Bos taurus 38-61 1944260-9 1991 The inhibition degree of bovine liver tyrosyl-tRNA synthetase decreased in the order: poly (G) greater than poly (I) greater than poly (I).poly (C) greater than poly (G).poly (C) greater than poly (C) greater than poly (A). Poly C 170-177 tyrosyl-tRNA synthetase 1 Bos taurus 38-61 1944260-9 1991 The inhibition degree of bovine liver tyrosyl-tRNA synthetase decreased in the order: poly (G) greater than poly (I) greater than poly (I).poly (C) greater than poly (G).poly (C) greater than poly (C) greater than poly (A). Poly C 170-177 tyrosyl-tRNA synthetase 1 Bos taurus 38-61 1848905-1 1991 When an oligonucleotide primer pG10 is incubated with the nucleotide analogue 9-[3-hydroxy-2-(hydroxymethyl)prop-1-yl] guanine diphosphate (pGp, I) in the presence of poly(C), addition of the monomer occurs almost exclusively at the 5"-terminal phosphate rather than the 3"-terminal cis-glycol. Poly C 167-173 phosphoglycolate phosphatase Homo sapiens 140-143 1872877-1 1991 The administration of the interferone inducer, polyriboinosinic.polyribocytidylic acid, inhibited the rise of activities of thymidylate synthase and thymidine kinase as well as DNA content in 24 h-regenerating rat liver in a dose dependent manner. Poly C 64-86 thymidylate synthetase Rattus norvegicus 124-144 2211840-4 1990 The biological effect of Poly(I).Poly(C)-induced feedback interferon is inhibited by the addition of sarcolectins, which also abolishes cellular refractoriness to repeated IFN induction. Poly C 33-40 interferon alpha 1 Homo sapiens 58-68 2211840-4 1990 The biological effect of Poly(I).Poly(C)-induced feedback interferon is inhibited by the addition of sarcolectins, which also abolishes cellular refractoriness to repeated IFN induction. Poly C 33-40 interferon alpha 1 Homo sapiens 172-175 2211840-5 1990 Similarly, sequential association of, first, Poly(I).Poly(C); 4-5 h later, sarcolectin restores the full capacity of both to promote cell growth, unrestrained by IFN. Poly C 53-60 keratin 7 Homo sapiens 75-86 2211840-5 1990 Similarly, sequential association of, first, Poly(I).Poly(C); 4-5 h later, sarcolectin restores the full capacity of both to promote cell growth, unrestrained by IFN. Poly C 53-60 interferon alpha 1 Homo sapiens 162-165 1706245-1 1990 Administration of the interferon inducer polyriboinosinic acid.polyribocytidylic acid (poly rl.poly rC) (10 mg/kg, ip) to male rats suppressed the constitutive hepatic expression of the male-specific cytochrome P-450 [AH, reduced-flavoprotein/oxygen oxidoreductase (RH hydroxylating), EC 1.14.14.1] isozyme P450IIC11 (P-450h) to 21% of control levels within 24 hr. Poly C 63-85 cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus 318-324 34293939-4 2021 In the first age-appropriate model for childhood arteriopathy-by administration of viral mimetic TLR3-agonist Polyinosinic:polycytidylic acid (Poly-IC) in juvenile mice-we identified a key role of the TLR3-neutrophil axis in disrupting the structural-functional integrity of the blood-brain barrier (BBB) and distorting the developing neurovascular architecture and vascular networks. Poly C 123-141 toll-like receptor 3 Mus musculus 97-101 1703958-12 1991 The activation of the dsRNA-dependent eIF-2 alpha kinase by regulatory RNA was prevented by addition of a high concentration of poly(I).poly(C). Poly C 136-143 eukaryotic translation initiation factor 2A Mus musculus 38-49 2107102-1 1990 Transcription of human interferon (IFN) gamma gene is induced in human peripheral lymphocyte nylon-nonadherent cells (NNA cells) by double strand RNA poly I:poly C [(1985) J. Interferon Res. Poly C 157-163 interferon gamma Homo sapiens 23-45 2107102-4 1990 For induction of IFN gamma gene expression, only initial 4 h treatment of poly I:poly C to NNA cells is sufficient. Poly C 81-87 interferon gamma Homo sapiens 17-26 2107102-5 1990 Addition of inhibitor of protein synthesis, cycloheximide (CHX), at an early stage of induction periods (0-4 h) inhibits the IFN gamma induction by poly I:poly C. Poly C 155-161 interferon gamma Homo sapiens 125-134 2107102-6 1990 Cell free translation assay using RNAs isolated from NNA cells which are induced by poly I:poly C in the presence of CHX reveals that in these RNAs, IFN gamma mRNA does not exist. Poly C 91-97 interferon gamma Homo sapiens 149-158 2407240-3 1990 Other stimulators of interleukin 6 production in chondrocytes include tumour necrosis factor-alpha, polyriboinosinic: polyribocytidylic acid and bacterial lipopolysaccharide. Poly C 118-140 interleukin 6 Homo sapiens 21-34 34906906-3 2022 In this context, this study addressed the relationship between the efficacy of talazoparib (TAL) as a PARPi and the activation of TLR3 or TLR9 by Polyinosinic:polycytidylic acid (Poly I:C) or CpG oligodeoxynucleotides (CpG-ODN) stimulation, respectively in triple negative breast cancer (TNBC). Poly C 159-177 toll like receptor 3 Homo sapiens 130-134 34906906-3 2022 In this context, this study addressed the relationship between the efficacy of talazoparib (TAL) as a PARPi and the activation of TLR3 or TLR9 by Polyinosinic:polycytidylic acid (Poly I:C) or CpG oligodeoxynucleotides (CpG-ODN) stimulation, respectively in triple negative breast cancer (TNBC). Poly C 159-177 toll like receptor 9 Homo sapiens 138-142 34949739-2 2022 In macrophages, necroptosis can be induced by co-treatment with Toll-like receptor (TLR) ligands (lipopolysaccharide (LPS) for TLR4 and polyinosinic-polycytidylic acid (poly I:C) for TLR3) and a cell-permeable pan-caspase inhibitor zVAD. Poly C 148-167 toll like receptor 3 Homo sapiens 183-187 2310829-1 1990 Interleukin-6 (IL-6), a multifunctional cytokine produced in monocytes, fibroblasts, endothelial cells, and keratinocytes, is induced by a variety of stimulating signals, including lipopolysaccharide (LPS), poly (I), poly (C), IL-1, tumor necrosis factor (TNF), and platelet-derived growth factor. Poly C 217-224 interleukin 6 Homo sapiens 0-13 2310829-1 1990 Interleukin-6 (IL-6), a multifunctional cytokine produced in monocytes, fibroblasts, endothelial cells, and keratinocytes, is induced by a variety of stimulating signals, including lipopolysaccharide (LPS), poly (I), poly (C), IL-1, tumor necrosis factor (TNF), and platelet-derived growth factor. Poly C 217-224 interleukin 6 Homo sapiens 15-19 2153928-3 1990 IFN-alpha mRNA remained undetectable in poly(I)-poly(C)-treated Daudi cells either before or after priming. Poly C 48-55 interferon alpha 1 Homo sapiens 0-9 1690591-4 1990 The levels of these two induced activities after VIP treatment are comparable to those induced by the poly (I).poly (C), an inducer of IFN beta/alpha in mammalian cells. Poly C 111-118 vasoactive intestinal peptide Homo sapiens 49-52 1690591-4 1990 The levels of these two induced activities after VIP treatment are comparable to those induced by the poly (I).poly (C), an inducer of IFN beta/alpha in mammalian cells. Poly C 111-118 interferon beta 1 Homo sapiens 135-143 33801464-6 2021 Furthermore, SARS-CoV-2 N inhibited polyinosinic: polycytidylic acid [poly(I:C)]-mediated IFN signaling at the level of Tank-binding kinase 1 (TBK1) and interfered with the association between TBK1 and interferon regulatory factor 3 (IRF3), subsequently preventing the nuclear translocation of IRF3. Poly C 50-68 nucleocapsid phosphoprotein Severe acute respiratory syndrome coronavirus 2 24-25 33801464-6 2021 Furthermore, SARS-CoV-2 N inhibited polyinosinic: polycytidylic acid [poly(I:C)]-mediated IFN signaling at the level of Tank-binding kinase 1 (TBK1) and interfered with the association between TBK1 and interferon regulatory factor 3 (IRF3), subsequently preventing the nuclear translocation of IRF3. Poly C 50-68 TANK binding kinase 1 Homo sapiens 120-141 33801464-6 2021 Furthermore, SARS-CoV-2 N inhibited polyinosinic: polycytidylic acid [poly(I:C)]-mediated IFN signaling at the level of Tank-binding kinase 1 (TBK1) and interfered with the association between TBK1 and interferon regulatory factor 3 (IRF3), subsequently preventing the nuclear translocation of IRF3. Poly C 50-68 TANK binding kinase 1 Homo sapiens 143-147 34755645-5 2021 Mechanistically, indoprofen potently inhibited the release of HMGB1 following stimulation by lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (poly I:C), and suppressed recombinant human HMGB1(rhHMGB1)-induced inflammatory responses. Poly C 134-152 high mobility group box 1 Homo sapiens 62-67 34293939-4 2021 In the first age-appropriate model for childhood arteriopathy-by administration of viral mimetic TLR3-agonist Polyinosinic:polycytidylic acid (Poly-IC) in juvenile mice-we identified a key role of the TLR3-neutrophil axis in disrupting the structural-functional integrity of the blood-brain barrier (BBB) and distorting the developing neurovascular architecture and vascular networks. Poly C 123-141 toll-like receptor 3 Mus musculus 201-205 34904931-2 2021 The present study has identified Poly (C) binding protein 2 (PCBP2) as a post-transcriptional suppresser for the expression of utrophin-A, the muscle-specific utrophin isoform. Poly C 33-41 poly(rC) binding protein 2 Mus musculus 61-66 34695651-5 2021 PU.1 expression also primes the cells to develop a strong immune response against the dsRNA virus mimic polyinosinic:polycytidylic acid (poly I:C) by significantly up-regulating Interferon-beta (14.9 fold change with p-value <0.0001). Poly C 117-135 Spi-1 proto-oncogene Homo sapiens 0-4 34695651-5 2021 PU.1 expression also primes the cells to develop a strong immune response against the dsRNA virus mimic polyinosinic:polycytidylic acid (poly I:C) by significantly up-regulating Interferon-beta (14.9 fold change with p-value <0.0001). Poly C 117-135 interferon beta 1 Homo sapiens 178-193 34821951-6 2021 We evaluated several TLR ligand combinations and demonstrated that polyinosinic:polycytidylic acid (poly(I:C)) and R848, ligands for TLR3 and TLR7/8, respectively, constituted the optimal combination for inducing a positive co-stimulatory profile in all BDC subsets. Poly C 80-98 toll like receptor 3 Homo sapiens 133-137 34821951-6 2021 We evaluated several TLR ligand combinations and demonstrated that polyinosinic:polycytidylic acid (poly(I:C)) and R848, ligands for TLR3 and TLR7/8, respectively, constituted the optimal combination for inducing a positive co-stimulatory profile in all BDC subsets. Poly C 80-98 toll like receptor 7 Homo sapiens 142-148 34232469-0 2021 Co-administration of toll-like receptor (TLR)-3 agonist Poly I:C with different infectious bursal disease (IBD) vaccines improves IBD specific immune response in chicken. Poly C 56-64 toll like receptor 3 Gallus gallus 21-47 34904931-2 2021 The present study has identified Poly (C) binding protein 2 (PCBP2) as a post-transcriptional suppresser for the expression of utrophin-A, the muscle-specific utrophin isoform. Poly C 33-41 utrophin Mus musculus 159-167 34693552-5 2022 Upon challenge with the immunostimulant polyinosinic:polycytidylic acid (poly(I:C)), NK cells isolated from Hpse-/- mice displayed impaired cytotoxicity against EO771.LMB cells and reduced levels of activation markers CD69 and NKG2D. Poly C 53-71 heparanase Mus musculus 108-112 34824158-1 2021 BACKGROUND: BO-112 is a nanoplexed form of polyinosinic:polycytidylic acid that acting on toll-like receptor 3 (TLR3), melanoma differentiation-associated protein 5 (MDA5) and protein kinase RNA-activated (PKR) elicits rejection of directly injected transplanted tumors, but has only modest efficacy against distant untreated tumors. Poly C 56-74 toll-like receptor 3 Mus musculus 90-110 34824158-1 2021 BACKGROUND: BO-112 is a nanoplexed form of polyinosinic:polycytidylic acid that acting on toll-like receptor 3 (TLR3), melanoma differentiation-associated protein 5 (MDA5) and protein kinase RNA-activated (PKR) elicits rejection of directly injected transplanted tumors, but has only modest efficacy against distant untreated tumors. Poly C 56-74 toll-like receptor 3 Mus musculus 112-116 34824158-1 2021 BACKGROUND: BO-112 is a nanoplexed form of polyinosinic:polycytidylic acid that acting on toll-like receptor 3 (TLR3), melanoma differentiation-associated protein 5 (MDA5) and protein kinase RNA-activated (PKR) elicits rejection of directly injected transplanted tumors, but has only modest efficacy against distant untreated tumors. Poly C 56-74 interferon induced with helicase C domain 1 Mus musculus 119-164 34824158-1 2021 BACKGROUND: BO-112 is a nanoplexed form of polyinosinic:polycytidylic acid that acting on toll-like receptor 3 (TLR3), melanoma differentiation-associated protein 5 (MDA5) and protein kinase RNA-activated (PKR) elicits rejection of directly injected transplanted tumors, but has only modest efficacy against distant untreated tumors. Poly C 56-74 interferon induced with helicase C domain 1 Mus musculus 166-170 34824158-1 2021 BACKGROUND: BO-112 is a nanoplexed form of polyinosinic:polycytidylic acid that acting on toll-like receptor 3 (TLR3), melanoma differentiation-associated protein 5 (MDA5) and protein kinase RNA-activated (PKR) elicits rejection of directly injected transplanted tumors, but has only modest efficacy against distant untreated tumors. Poly C 56-74 eukaryotic translation initiation factor 2-alpha kinase 2 Mus musculus 176-204 34824158-1 2021 BACKGROUND: BO-112 is a nanoplexed form of polyinosinic:polycytidylic acid that acting on toll-like receptor 3 (TLR3), melanoma differentiation-associated protein 5 (MDA5) and protein kinase RNA-activated (PKR) elicits rejection of directly injected transplanted tumors, but has only modest efficacy against distant untreated tumors. Poly C 56-74 eukaryotic translation initiation factor 2-alpha kinase 2 Mus musculus 206-209 34693552-5 2022 Upon challenge with the immunostimulant polyinosinic:polycytidylic acid (poly(I:C)), NK cells isolated from Hpse-/- mice displayed impaired cytotoxicity against EO771.LMB cells and reduced levels of activation markers CD69 and NKG2D. Poly C 53-71 killer cell lectin-like receptor subfamily K, member 1 Mus musculus 227-232 34643794-5 2022 Pro-inflammatory signaling was induced by TLR-3 agonist polyinosinic:polycytidylic acid (Poly I:C). Poly C 69-87 toll like receptor 3 Homo sapiens 42-47 34667099-3 2021 Furthermore, the NF-kappaB signaling axis and TRIF-mediated necroptosis were also strongly reduced in response to LPS and polyinosinic:polycytidylic acid. Poly C 135-153 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 17-26 34667099-3 2021 Furthermore, the NF-kappaB signaling axis and TRIF-mediated necroptosis were also strongly reduced in response to LPS and polyinosinic:polycytidylic acid. Poly C 135-153 toll-like receptor adaptor molecule 2 Mus musculus 46-50 34616125-6 2021 Cytokine array and enzymelinked immunosorbent assay analysis showed increased expression of inflammatory cytokines such as interleukin6 and granulocyte-macrophage colony-stimulating factor by polyinosinic-polycytidylic acid stimulation, with expression levels differing according to hot springs hydrochemical composition. Poly C 205-223 interleukin 6 Homo sapiens 123-135 34303791-2 2021 Polyinosinic:polycytidylic acid (PIC) is a Toll-like receptor 3 (TLR3) agonist that induces tumor cells apoptosis after activation. Poly C 13-31 toll like receptor 3 Homo sapiens 43-63 34303791-2 2021 Polyinosinic:polycytidylic acid (PIC) is a Toll-like receptor 3 (TLR3) agonist that induces tumor cells apoptosis after activation. Poly C 13-31 toll like receptor 3 Homo sapiens 65-69 34616125-6 2021 Cytokine array and enzymelinked immunosorbent assay analysis showed increased expression of inflammatory cytokines such as interleukin6 and granulocyte-macrophage colony-stimulating factor by polyinosinic-polycytidylic acid stimulation, with expression levels differing according to hot springs hydrochemical composition. Poly C 205-223 colony stimulating factor 2 Homo sapiens 140-188 34512638-8 2021 Ligation of TLR3 by polyI:C in BSMCs was associated with increased TLR3 mRNA expression, and 1,25D3 treatment significantly reduced its expression. Poly C 20-27 toll like receptor 3 Homo sapiens 12-16 34512638-8 2021 Ligation of TLR3 by polyI:C in BSMCs was associated with increased TLR3 mRNA expression, and 1,25D3 treatment significantly reduced its expression. Poly C 20-27 toll like receptor 3 Homo sapiens 67-71 34512638-9 2021 In addition, 1,25D3 decreased the expression of IL-6, IFN-beta1, CCL2, FN1 and COL1A1 induced by polyI:C in BSMCs. Poly C 97-104 interleukin 6 Homo sapiens 48-52 34512638-9 2021 In addition, 1,25D3 decreased the expression of IL-6, IFN-beta1, CCL2, FN1 and COL1A1 induced by polyI:C in BSMCs. Poly C 97-104 interferon alpha 1 Homo sapiens 54-63 34512638-9 2021 In addition, 1,25D3 decreased the expression of IL-6, IFN-beta1, CCL2, FN1 and COL1A1 induced by polyI:C in BSMCs. Poly C 97-104 C-C motif chemokine ligand 2 Homo sapiens 65-69 34512638-9 2021 In addition, 1,25D3 decreased the expression of IL-6, IFN-beta1, CCL2, FN1 and COL1A1 induced by polyI:C in BSMCs. Poly C 97-104 fibronectin 1 Homo sapiens 71-74 34512638-9 2021 In addition, 1,25D3 decreased the expression of IL-6, IFN-beta1, CCL2, FN1 and COL1A1 induced by polyI:C in BSMCs. Poly C 97-104 collagen type I alpha 1 chain Homo sapiens 79-85 34990938-7 2022 After challenge with Streptococcus agalactiae, lipopolysaccharides (LPS) and polyinosinic polycytidylic acid (Poly I:C), the expression level of Onddx43 mRNA was upregulated or downregulated in all of the tissues tested. Poly C 110-118 probable ATP-dependent RNA helicase DDX43 Oreochromis niloticus 145-152 34233389-1 2021 Poly(rC)-binding protein 2 (PCBP2) is an RNA-binding protein that is characterized by its ability to interact with poly(C) with high affinity in a sequence-specific manner. Poly C 115-122 poly(rC) binding protein 2 Homo sapiens 0-26 34233389-1 2021 Poly(rC)-binding protein 2 (PCBP2) is an RNA-binding protein that is characterized by its ability to interact with poly(C) with high affinity in a sequence-specific manner. Poly C 115-122 poly(rC) binding protein 2 Homo sapiens 28-33 34233389-1 2021 Poly(rC)-binding protein 2 (PCBP2) is an RNA-binding protein that is characterized by its ability to interact with poly(C) with high affinity in a sequence-specific manner. Poly C 115-122 RNA binding motif single stranded interacting protein 3 Homo sapiens 41-60 35232977-8 2022 Finally, we observed that RP5-998N21.4OE can enhance IFIT2- and IFIT3-mediated immune defense responses through activation of signal transducer and activator of transcription 1 (STAT1) signaling pathway in U251 astrocytoma cells under treatment with the viral mimetic polyinosinic: polycytidylic acid (poly I:C). Poly C 282-300 interferon induced protein with tetratricopeptide repeats 2 Homo sapiens 53-58 35232977-8 2022 Finally, we observed that RP5-998N21.4OE can enhance IFIT2- and IFIT3-mediated immune defense responses through activation of signal transducer and activator of transcription 1 (STAT1) signaling pathway in U251 astrocytoma cells under treatment with the viral mimetic polyinosinic: polycytidylic acid (poly I:C). Poly C 282-300 interferon induced protein with tetratricopeptide repeats 3 Homo sapiens 64-69 35232977-8 2022 Finally, we observed that RP5-998N21.4OE can enhance IFIT2- and IFIT3-mediated immune defense responses through activation of signal transducer and activator of transcription 1 (STAT1) signaling pathway in U251 astrocytoma cells under treatment with the viral mimetic polyinosinic: polycytidylic acid (poly I:C). Poly C 282-300 signal transducer and activator of transcription 1 Homo sapiens 126-176 35232977-8 2022 Finally, we observed that RP5-998N21.4OE can enhance IFIT2- and IFIT3-mediated immune defense responses through activation of signal transducer and activator of transcription 1 (STAT1) signaling pathway in U251 astrocytoma cells under treatment with the viral mimetic polyinosinic: polycytidylic acid (poly I:C). Poly C 282-300 signal transducer and activator of transcription 1 Homo sapiens 178-183 35163772-3 2022 The liposomal vaccine adjuvant CAF 09b contains the TLR3 agonist polyinosinic:polycytidylic acid, which induces a type I interferon (IFN-I) response and an antiviral state in the affected tissues. Poly C 78-96 toll like receptor 3 Homo sapiens 52-56 35280398-0 2022 Polyinosinic:polycytidylic acid aggravates calcipotriol-induced atopic dermatitis-like skin lesions in mice by increasing the expression of thymic stromal lymphopoietin. Poly C 13-31 thymic stromal lymphopoietin Mus musculus 140-168 35174347-5 2022 Our results showed that stimulation with polyinosinic:polycytidylic acids (Poly (I:C)), a synthetic agonist for TLR3 signaling, increased the mRNA expression of PPDPF in chicken fibroblasts DF-1 but not in chicken macrophage-like cells HD11. Poly C 54-73 toll like receptor 3 Gallus gallus 112-116 35221299-3 2022 In this study, we used Beas-2B human bronchial epithelial cells to investigate the effects of the TLR3 agonist polyinosinic:polycytidylic acid (Poly(I:C)) on airway cell migration and primary cilia (PC) formation. Poly C 124-142 toll like receptor 3 Homo sapiens 98-102 34983106-5 2022 In vitro, polyinosinic:polycytidylic acid (Poly I-C) treatment markedly enhanced the production of SAA1 from AECs, which was further augmented by neutrophils; SAA1 could induce the production of interleukin (IL)-6, IL-8, and S100 calcium-binding protein A9 from AECs. Poly C 23-41 serum amyloid A1 Homo sapiens 99-103 34983106-5 2022 In vitro, polyinosinic:polycytidylic acid (Poly I-C) treatment markedly enhanced the production of SAA1 from AECs, which was further augmented by neutrophils; SAA1 could induce the production of interleukin (IL)-6, IL-8, and S100 calcium-binding protein A9 from AECs. Poly C 23-41 serum amyloid A1 Homo sapiens 159-163 34983106-5 2022 In vitro, polyinosinic:polycytidylic acid (Poly I-C) treatment markedly enhanced the production of SAA1 from AECs, which was further augmented by neutrophils; SAA1 could induce the production of interleukin (IL)-6, IL-8, and S100 calcium-binding protein A9 from AECs. Poly C 23-41 interleukin 6 Homo sapiens 195-213 34983106-5 2022 In vitro, polyinosinic:polycytidylic acid (Poly I-C) treatment markedly enhanced the production of SAA1 from AECs, which was further augmented by neutrophils; SAA1 could induce the production of interleukin (IL)-6, IL-8, and S100 calcium-binding protein A9 from AECs. Poly C 23-41 C-X-C motif chemokine ligand 8 Homo sapiens 215-219 34983106-5 2022 In vitro, polyinosinic:polycytidylic acid (Poly I-C) treatment markedly enhanced the production of SAA1 from AECs, which was further augmented by neutrophils; SAA1 could induce the production of interleukin (IL)-6, IL-8, and S100 calcium-binding protein A9 from AECs. Poly C 23-41 S100 calcium binding protein A9 Homo sapiens 225-256 35174347-5 2022 Our results showed that stimulation with polyinosinic:polycytidylic acids (Poly (I:C)), a synthetic agonist for TLR3 signaling, increased the mRNA expression of PPDPF in chicken fibroblasts DF-1 but not in chicken macrophage-like cells HD11. Poly C 54-73 pancreatic progenitor cell differentiation and proliferation factor Gallus gallus 161-166 3226465-4 1988 The enzyme shows all the characteristics described for casein kinase II from other sources: it is independent of cyclic nucleotides, calcium/phospholipids, and double-stranded poly(I).poly(C); it can utilize both ATP and GTP as phosphoryl donors and can phosphorylate both casein and phosvitin but not histone. Poly C 184-191 casein kinase 2 beta Bos taurus 284-293 2557635-5 1989 In L929 cells, treatment with poly(I).poly(C) under conditions that failed to induce significant levels of IFN-beta mRNA led to a very low induction of IRF-1 mRNA, but "priming" cells with IFN prior to the addition of poly(I).poly(C) greatly increased both IRF-1 and IFN-beta mRNAs. Poly C 38-44 interferon regulatory factor 1 Mus musculus 152-157 2557635-5 1989 In L929 cells, treatment with poly(I).poly(C) under conditions that failed to induce significant levels of IFN-beta mRNA led to a very low induction of IRF-1 mRNA, but "priming" cells with IFN prior to the addition of poly(I).poly(C) greatly increased both IRF-1 and IFN-beta mRNAs. Poly C 38-44 interferon regulatory factor 1 Mus musculus 257-262 2557635-5 1989 In L929 cells, treatment with poly(I).poly(C) under conditions that failed to induce significant levels of IFN-beta mRNA led to a very low induction of IRF-1 mRNA, but "priming" cells with IFN prior to the addition of poly(I).poly(C) greatly increased both IRF-1 and IFN-beta mRNAs. Poly C 38-44 interferon beta 1, fibroblast Mus musculus 267-275 2542091-4 1989 The level of activation of PKC is quite remarkable in the case of the combined stimulation by poly(I):poly(C) and TPA as compared to poly(I):poly(C) alone. Poly C 141-148 plasminogen activator, tissue type Homo sapiens 114-117 2542091-6 1989 Moreover, inhibition experiments using the PKC inhibitor H-7 and cAMP-dependent protein kinase inhibitor H-8 suggest that the mechanism of signal transduction with regard to PKC is involved in stimulation of IFN gamma production in NNA cells by poly(I):poly(C) in the presence of TPA and that along with PKC, cAMP-dependent protein kinase is probably involved in induction of IFN gamma by stimulation with poly(I):poly(C) alone. Poly C 253-259 interferon gamma Homo sapiens 208-217 2542091-6 1989 Moreover, inhibition experiments using the PKC inhibitor H-7 and cAMP-dependent protein kinase inhibitor H-8 suggest that the mechanism of signal transduction with regard to PKC is involved in stimulation of IFN gamma production in NNA cells by poly(I):poly(C) in the presence of TPA and that along with PKC, cAMP-dependent protein kinase is probably involved in induction of IFN gamma by stimulation with poly(I):poly(C) alone. Poly C 253-260 interferon gamma Homo sapiens 208-217 2647497-0 1989 Production of interferon-beta upon induction with polyinosinic acid:polycytidylic acid during the cell cycle of human fibroblasts. Poly C 68-86 interferon beta 1 Homo sapiens 14-29 2647497-1 1989 The production of interferon-beta was examined at various stages of the cell cycle in synchronized and unsynchronized cell populations induced by poly(I):poly(C). Poly C 154-161 interferon beta 1 Homo sapiens 18-33 2647497-2 1989 Human fibroblasts were synchronized with mitotic detachment and, at different stages of the cell cycle, poly(I):poly(C) was added for induction of interferon-beta. Poly C 112-119 interferon beta 1 Homo sapiens 147-162 2465167-0 1989 Interleukin 1 and poly(rI).poly(rC) induce production of granulocyte CSF, macrophage CSF, and granulocyte-macrophage CSF by human endothelial cells. Poly C 27-35 interleukin 1 alpha Homo sapiens 0-13 2465167-0 1989 Interleukin 1 and poly(rI).poly(rC) induce production of granulocyte CSF, macrophage CSF, and granulocyte-macrophage CSF by human endothelial cells. Poly C 27-35 colony stimulating factor 2 Homo sapiens 69-72 2465167-0 1989 Interleukin 1 and poly(rI).poly(rC) induce production of granulocyte CSF, macrophage CSF, and granulocyte-macrophage CSF by human endothelial cells. Poly C 27-35 colony stimulating factor 2 Homo sapiens 85-88 2465167-0 1989 Interleukin 1 and poly(rI).poly(rC) induce production of granulocyte CSF, macrophage CSF, and granulocyte-macrophage CSF by human endothelial cells. Poly C 27-35 colony stimulating factor 2 Homo sapiens 85-88 2465167-5 1989 The kinetics of IL-1-induced CSA release as opposed to poly(rI).poly(rC)-induced release were found to be different, in that poly(rI).poly(rC)-induced CSA production occurred more slowly. Poly C 64-72 interleukin 1 beta Homo sapiens 16-20 2465167-5 1989 The kinetics of IL-1-induced CSA release as opposed to poly(rI).poly(rC)-induced release were found to be different, in that poly(rI).poly(rC)-induced CSA production occurred more slowly. Poly C 134-142 interleukin 1 beta Homo sapiens 16-20 2465167-7 1989 Using specific immunologic assays, IL-1- as well as poly(rI).poly(rC)-inducible production of granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF, and macrophage CSF was found. Poly C 61-69 interleukin 1 beta Homo sapiens 35-39 2465167-7 1989 Using specific immunologic assays, IL-1- as well as poly(rI).poly(rC)-inducible production of granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF, and macrophage CSF was found. Poly C 61-69 colony stimulating factor 3 Homo sapiens 94-131 2465167-7 1989 Using specific immunologic assays, IL-1- as well as poly(rI).poly(rC)-inducible production of granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF, and macrophage CSF was found. Poly C 61-69 colony stimulating factor 3 Homo sapiens 133-138 2465167-7 1989 Using specific immunologic assays, IL-1- as well as poly(rI).poly(rC)-inducible production of granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF, and macrophage CSF was found. Poly C 61-69 colony stimulating factor 2 Homo sapiens 135-138 2465167-7 1989 Using specific immunologic assays, IL-1- as well as poly(rI).poly(rC)-inducible production of granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF, and macrophage CSF was found. Poly C 61-69 colony stimulating factor 2 Homo sapiens 164-167 2537976-1 1989 Human tumor necrosis factor alpha (TNF-alpha) gene expression can be induced primarily in cells of the monocyte/macrophage lineage by a variety of inducers, including lipopolysaccharide, phorbol esters such as phorbol 12-myristate 13-acetate, and virus or synthetic double-stranded RNA [poly(I).poly(C)]. Poly C 295-302 tumor necrosis factor Homo sapiens 6-33 2537976-1 1989 Human tumor necrosis factor alpha (TNF-alpha) gene expression can be induced primarily in cells of the monocyte/macrophage lineage by a variety of inducers, including lipopolysaccharide, phorbol esters such as phorbol 12-myristate 13-acetate, and virus or synthetic double-stranded RNA [poly(I).poly(C)]. Poly C 295-302 tumor necrosis factor Homo sapiens 35-44 2715669-5 1989 Multiple phosphorylated species of a 72-kD protein were labeled in response to poly(I):poly(C) by extracts from IFN-treated cells but not by extracts from control cells. Poly C 87-94 interferon alpha 1 Homo sapiens 112-115 2607779-8 1989 Survival times of the mice inoculated with the LL-2 cells were prolonged by administrations of an inducer of differentiation, poly(I).poly(C). Poly C 134-141 peroxiredoxin 2, pseudogene 1 Mus musculus 47-51 2607779-9 1989 We found morphological changes in the peritoneal blastic LL-2 cells to mature macrophage-like cells after the serial administrations of poly(I).poly(C) to the recipient mice. Poly C 144-151 peroxiredoxin 2, pseudogene 1 Mus musculus 57-61 2557635-2 1989 Here we show that in both human FS-4 and murine L929 cells, steady-state levels of IRF-1 mRNA were increased by treatment with tumor necrosis factor (TNF), interleukin 1 (IL-1), poly(I).poly(C), or IFN-beta. Poly C 186-192 interferon regulatory factor 1 Mus musculus 83-88 2557635-2 1989 Here we show that in both human FS-4 and murine L929 cells, steady-state levels of IRF-1 mRNA were increased by treatment with tumor necrosis factor (TNF), interleukin 1 (IL-1), poly(I).poly(C), or IFN-beta. Poly C 186-192 tumor necrosis factor Mus musculus 127-148 2557635-2 1989 Here we show that in both human FS-4 and murine L929 cells, steady-state levels of IRF-1 mRNA were increased by treatment with tumor necrosis factor (TNF), interleukin 1 (IL-1), poly(I).poly(C), or IFN-beta. Poly C 186-192 tumor necrosis factor Mus musculus 150-153 2557635-5 1989 In L929 cells, treatment with poly(I).poly(C) under conditions that failed to induce significant levels of IFN-beta mRNA led to a very low induction of IRF-1 mRNA, but "priming" cells with IFN prior to the addition of poly(I).poly(C) greatly increased both IRF-1 and IFN-beta mRNAs. Poly C 38-45 interferon regulatory factor 1 Mus musculus 152-157 2557635-5 1989 In L929 cells, treatment with poly(I).poly(C) under conditions that failed to induce significant levels of IFN-beta mRNA led to a very low induction of IRF-1 mRNA, but "priming" cells with IFN prior to the addition of poly(I).poly(C) greatly increased both IRF-1 and IFN-beta mRNAs. Poly C 38-45 interferon regulatory factor 1 Mus musculus 257-262 2557635-5 1989 In L929 cells, treatment with poly(I).poly(C) under conditions that failed to induce significant levels of IFN-beta mRNA led to a very low induction of IRF-1 mRNA, but "priming" cells with IFN prior to the addition of poly(I).poly(C) greatly increased both IRF-1 and IFN-beta mRNAs. Poly C 38-45 interferon beta 1, fibroblast Mus musculus 267-275 2502582-3 1989 Coculture of M phi with IFN-gamma and polyinosinic-polycytidylic acid [poly(I):poly(C)] resulted in the reduction of Ia expression in comparison with those cultured without poly(I):poly(C). Poly C 79-86 interferon gamma Homo sapiens 24-33 2502582-3 1989 Coculture of M phi with IFN-gamma and polyinosinic-polycytidylic acid [poly(I):poly(C)] resulted in the reduction of Ia expression in comparison with those cultured without poly(I):poly(C). Poly C 79-85 interferon gamma Homo sapiens 24-33 2502582-4 1989 Pretreatment of M phi with poly(I):poly(C) or a bacterial lipopolysaccharide (LPS), which is also a potent IFN inducer, in vitro or in vivo, before being exposed to IFN-gamma was also effective in suppressing the Ia expression. Poly C 35-42 interferon alpha 1 Homo sapiens 107-110 2502585-2 1989 In MNC, poly(I):poly(C) and mismatched poly(I):poly(C) induced IFN-alpha in a dose-dependent manner, whereas poly(ICLC) was unable to do so in concentrations that ranged from 1 to 160 micrograms/ml. Poly C 16-22 interferon alpha 1 Homo sapiens 63-72 2502585-2 1989 In MNC, poly(I):poly(C) and mismatched poly(I):poly(C) induced IFN-alpha in a dose-dependent manner, whereas poly(ICLC) was unable to do so in concentrations that ranged from 1 to 160 micrograms/ml. Poly C 47-53 interferon alpha 1 Homo sapiens 63-72 2502585-4 1989 The capacity of poly(I):poly(C) to induce IFN-alpha was reestablished only in monocyte cultures when, prior to the stimulation, the cells were exposed for at least 2 h to supernatants from poly(I):poly(C)-stimulated lymphocyte cultures. Poly C 24-31 interferon alpha 1 Homo sapiens 42-51 2502585-4 1989 The capacity of poly(I):poly(C) to induce IFN-alpha was reestablished only in monocyte cultures when, prior to the stimulation, the cells were exposed for at least 2 h to supernatants from poly(I):poly(C)-stimulated lymphocyte cultures. Poly C 197-204 interferon alpha 1 Homo sapiens 42-51 2542091-0 1989 The roles of protein kinase C and cyclic nucleotide dependent kinase in signal transduction in human interferon gamma induction by poly I:poly C. Poly C 138-144 interferon gamma Homo sapiens 101-117 2542091-1 1989 The signal transduction mechanisms involved in interferon (IFN) gamma induction in human peripheral mononuclear lymphocyte nylon-nonadherent cells (NNA cells) by stimulation with poly(I):poly(C) are investigated. Poly C 187-194 interferon gamma Homo sapiens 47-69 2542091-2 1989 Significant enhancement of IFN gamma production by poly(I):poly(C) is observed in the presence of the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA, a protein kinase C (PKC) activator). Poly C 59-66 interferon gamma Homo sapiens 27-36 2542091-2 1989 Significant enhancement of IFN gamma production by poly(I):poly(C) is observed in the presence of the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA, a protein kinase C (PKC) activator). Poly C 59-66 plasminogen activator, tissue type Homo sapiens 155-158 2848929-4 1988 These results confirm earlier observations that IFN or polyinosinic.polycytidylic acid block the replication of HSV-1 in human, monkey and mouse cells no later than the immediate early phase of infection. Poly C 68-86 interferon alpha 1 Homo sapiens 48-51 3182859-1 1988 The asparagine-linked sugar chains of natural interferon-beta 1 secreted from human foreskin fibroblasts by poly I:poly C induction and of three recombinant human interferon-beta 1 produced by Chinese hamster ovary cells, mouse epithelial cells (C127), and human lung adenocarcinoma cells (PC8) were released quantitatively as oligosaccharides by hydrazinolysis followed by N-acetylation. Poly C 115-121 interferon beta 1 Homo sapiens 46-63 2458149-5 1988 The kinetics of IL-1- and poly(rI).poly(rC)-induced CSA release were found to be different, in that poly(rI).poly(rC)-induced CSA production occurred more slowly. Poly C 35-43 interleukin 1 alpha Homo sapiens 16-20 2458149-5 1988 The kinetics of IL-1- and poly(rI).poly(rC)-induced CSA release were found to be different, in that poly(rI).poly(rC)-induced CSA production occurred more slowly. Poly C 109-117 interleukin 1 alpha Homo sapiens 16-20 3262700-4 1988 To elucidate the mechanism of this inhibition, we examined the effect of IL1 on the synthesis of interferon-beta (IFN-beta), stimulated with polyinosinate.polycytidylate [poly(I).poly(C)]. Poly C 179-185 interferon beta 1 Homo sapiens 114-122 3262700-6 1988 However, when IL1 was added simultaneously with poly(I).poly(C), or 2 h after poly(I).poly(C), IFN-beta synthesis was increased. Poly C 56-63 interleukin 1 alpha Homo sapiens 14-17 3262700-6 1988 However, when IL1 was added simultaneously with poly(I).poly(C), or 2 h after poly(I).poly(C), IFN-beta synthesis was increased. Poly C 56-62 interleukin 1 alpha Homo sapiens 14-17 3262700-7 1988 The inhibitory action of IL1 on poly(I).poly(C)-induced IFN-beta synthesis was abolished in the presence of cycloheximide, suggesting that it is mediated indirectly by an IL1-induced product in the FS-4 cells. Poly C 40-47 interleukin 1 alpha Homo sapiens 25-28 3262700-7 1988 The inhibitory action of IL1 on poly(I).poly(C)-induced IFN-beta synthesis was abolished in the presence of cycloheximide, suggesting that it is mediated indirectly by an IL1-induced product in the FS-4 cells. Poly C 40-47 interferon beta 1 Homo sapiens 56-64 3262700-7 1988 The inhibitory action of IL1 on poly(I).poly(C)-induced IFN-beta synthesis was abolished in the presence of cycloheximide, suggesting that it is mediated indirectly by an IL1-induced product in the FS-4 cells. Poly C 40-47 interleukin 1 alpha Homo sapiens 171-174 2453506-1 1988 Human fibroblasts were induced to secrete interferon (IFN) by treatment with the double-stranded RNA poly(inosinic).poly(cytidylic) acid or by infection with Newcastle disease virus. Poly C 116-136 interferon alpha 1 Homo sapiens 54-57 2837525-5 1988 Significant percentages (greater than 25%) of the LGL found in the liver and peritoneal cavity following viral infection or interferon induction with poly-inosinic:poly-cytidylic acid were defined morphologically as blasts (large cells with prominent nucleoli and intensely basophilic cytoplasms containing azurophilic granules). Poly C 164-183 legless Mus musculus 50-53 2458149-6 1988 Anti-IL-1 antiserum was able to completely neutralize the IL-1-induced CSA release, but had no effect on poly(rI).poly(rC)-induced CSF production, suggesting that the latter effect was mediated by other mechanisms than IL-1 in supernatant. Poly C 114-122 colony stimulating factor 2 Homo sapiens 131-134 2458149-8 1988 Poly(rI).poly(rC) appeared to be a better inducer for M-CSF than IL-1. Poly C 9-17 colony stimulating factor 1 Homo sapiens 54-59 2451028-9 1988 Poly(rC) and poly(dC) bind to rho competitively and with equal affinity and site size, although poly(rC) is the strongest cofactor for activating rho-dependent ATPase and poly(dC) has no ATPase cofactor activity at all. Poly C 0-8 ATPase Escherichia coli 160-166 2826599-13 1988 These results show that the observed conditioned enhancement of NK activity in conditioned animals is not caused by any nociceptive properties of the CS itself and is dependent on the IFN-beta produced after Poly I:C injection in the conditioned paradigm. Poly C 208-216 interferon beta 1, fibroblast Mus musculus 184-192 3262700-5 1988 When added 2 h or more before poly(I).poly(C), both forms of IL1 had a strong inhibitory effect on IFN-beta synthesis, as determined by antiviral assay of the IFN-beta protein or by quantitation of IFN-beta mRNA levels in Northern blot analysis. Poly C 38-45 interleukin 1 alpha Homo sapiens 61-64 3262700-5 1988 When added 2 h or more before poly(I).poly(C), both forms of IL1 had a strong inhibitory effect on IFN-beta synthesis, as determined by antiviral assay of the IFN-beta protein or by quantitation of IFN-beta mRNA levels in Northern blot analysis. Poly C 38-45 interferon beta 1 Homo sapiens 99-107 2449288-4 1987 Fibroblast cells grown on microcarriers in the presence of glucocorticoid hormones maintained their ability to produce interferon (IFN)-beta in a superinduction method with poly I: poly C and antimetabolites. Poly C 181-187 interferon beta 1 Homo sapiens 119-140 3689426-8 1987 Compared to controls, cytochrome P-450 in both the lungs and livers of poly I:poly C treated rats declined by 40% at 24 hr and 55% at 48 hr (P less than 0.01). Poly C 78-84 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 22-38 3689426-10 1987 In contrast, cytochrome b5 levels declined by less than 30% of control values during the first 48 hr following poly I:poly C injection (P less than 0.01) and returned to control levels by 72 hr. Poly C 118-124 cytochrome b5 type A Rattus norvegicus 13-26 2440179-8 1987 In the absence of virus infection, decreased levels of p68 kinase occur in cells following incubation with poly(I).poly(C). Poly C 115-122 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 55-65 3279118-9 1988 PCT-GF activity in supernatants of human FS-4 fibroblasts stimulated with TNF, IL-1 or poly(I).poly(C) was neutralized by antibody to rBSF-2, but not by antibodies neutralizing the antiviral activity of IFN-beta. Poly C 95-102 tumor necrosis factor Homo sapiens 74-77 3279118-9 1988 PCT-GF activity in supernatants of human FS-4 fibroblasts stimulated with TNF, IL-1 or poly(I).poly(C) was neutralized by antibody to rBSF-2, but not by antibodies neutralizing the antiviral activity of IFN-beta. Poly C 95-102 interferon beta 1 Homo sapiens 203-211 3805129-4 1987 Antiserum to interferon (IFN)-beta, added to poly(I).poly(C)-stimulated cultures in order to neutralize endogenously generated IFN, markedly amplified the mitogenic action. Poly C 53-60 interferon beta 1 Homo sapiens 13-34 3545852-0 1987 Interleukin 1 and poly(rI).poly(rC) induce production of a hybridoma growth factor by human fibroblasts. Poly C 27-35 interleukin 1 alpha Homo sapiens 0-13 3545852-0 1987 Interleukin 1 and poly(rI).poly(rC) induce production of a hybridoma growth factor by human fibroblasts. Poly C 27-35 interleukin 6 Homo sapiens 59-82 3805129-2 1987 Poly(I).poly(C) is a potent inducer of interferon (IFN)-beta in human fibroblasts. Poly C 8-15 interferon beta 1 Homo sapiens 39-60 3805129-4 1987 Antiserum to interferon (IFN)-beta, added to poly(I).poly(C)-stimulated cultures in order to neutralize endogenously generated IFN, markedly amplified the mitogenic action. Poly C 53-60 interferon alpha 1 Homo sapiens 25-28 3805129-7 1987 This effect of dexamethasone correlated with its marked inhibitory action on poly(I).poly(C)-stimulated IFN production. Poly C 85-92 interferon alpha 1 Homo sapiens 104-107 6206680-2 1984 A CSF Poly(C)-avid ribonuclease (RNase) activity was determined in serum and CSF of 11 controls and 75 neurological patients (34 multiple sclerosis (MS), 18 infectious processes and 23 other neurological diseases (OND]. Poly C 6-13 colony stimulating factor 2 Homo sapiens 2-5 3758081-1 1986 When human fibroblast cells were stimulated with poly(I) X poly(C) in the presence of cycloheximide for the production of interferon-beta (IFN-beta), a 26-kDa protein could be immunoprecipitated by antiserum raised against partially purified human IFN-beta [Content, J., De Wit, L., Pierard, D., Derynck, R., De Clercq, E. & Fiers, W. (1982) Proc. Poly C 59-66 interferon beta 1 Homo sapiens 122-137 3758081-1 1986 When human fibroblast cells were stimulated with poly(I) X poly(C) in the presence of cycloheximide for the production of interferon-beta (IFN-beta), a 26-kDa protein could be immunoprecipitated by antiserum raised against partially purified human IFN-beta [Content, J., De Wit, L., Pierard, D., Derynck, R., De Clercq, E. & Fiers, W. (1982) Proc. Poly C 59-66 interferon beta 1 Homo sapiens 139-147 3758081-1 1986 When human fibroblast cells were stimulated with poly(I) X poly(C) in the presence of cycloheximide for the production of interferon-beta (IFN-beta), a 26-kDa protein could be immunoprecipitated by antiserum raised against partially purified human IFN-beta [Content, J., De Wit, L., Pierard, D., Derynck, R., De Clercq, E. & Fiers, W. (1982) Proc. Poly C 59-66 interferon beta 1 Homo sapiens 248-256 3936614-4 1985 Partially thiolated polycytidylic acid (MPC) strongly inhibited only the DNA polymerase alpha of the "normal" cell line, whereas the corresponding enzymes of all three leukemic cell lines were relatively insensitive to MPC. Poly C 20-38 DNA polymerase alpha 1, catalytic subunit Homo sapiens 73-93 2414376-2 1985 An IFN-alpha 1 cDNA insert containing such sequences can be used to isolate 15 IFN-beta 1 cDNA colonies present in a 2600-strong library in Escherichia coli prepared from polyadenylated RNA extracted from human diploid fibroblasts (FS-4) induced with poly(I).poly(C). Poly C 259-265 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 83-89 3921246-1 1985 The cytocidal activity of human immune interferon (IFN-gamma) in combination with the synthetic double-stranded RNA, poly(I).poly(C), was investigated in human colon carcinoma cell line HT-29. Poly C 125-132 interferon gamma Homo sapiens 32-60 3921246-2 1985 Three days of treatment with IFN-gamma (10 to 25 units/ml) resulted in 30 to 40% reduction in colony formation, whereas poly(I).poly(C) (25 to 100 micrograms/ml) reduced cell viability by 10 to 20% of control. Poly C 128-135 interferon gamma Homo sapiens 29-38 3921246-3 1985 The lethal effect of the combination of IFN-gamma and poly(I).poly(C) was synergistic wherein 70 to 90% reduction in colony formation was observed. Poly C 62-69 interferon gamma Homo sapiens 40-49 3921246-4 1985 Measurements of DNA, RNA, and protein synthesis after IFN-gamma and poly(I).poly(C) treatment showed a dose-dependent reduction in all three parameters. Poly C 76-83 interferon gamma Homo sapiens 54-63 3921246-5 1985 Recombinant IFN-gamma in combination with poly(I).poly(C) exhibited a similar effect. Poly C 50-57 interferon gamma Homo sapiens 12-21 3919027-7 1985 The 67-kDa protein kinase, uninducible by treatment with alpha, beta IFN (up to 13,000 units/ml), is instead induced upon treatment with gamma IFN at a similar rate of activity as in wild-type Friend leukemia cells, both when assayed in solution and after immobilization on poly(rI) X poly(rC)-agarose. Poly C 285-294 interferon gamma Mus musculus 143-146 2578572-4 1985 IFN was implicated as mediating the effect of poly(I)-poly(C) because high systemic levels of IFN were evident after injection, and neither the magnitude of the inflammatory response nor the T-cell levels were affected when poly(I)-poly(C)-treated mice were also given anti-IFN antiserum. Poly C 54-61 interferon alpha 1 Homo sapiens 0-3 2578572-5 1985 However, the poly(I)-poly(C)-induced IFN did not seem to reduce the localized inflammatory response by affecting viral replication in brain tissue because the vaccinia virus titers present on days 6 through 8 of infection were similar to the titers in phosphate-buffered saline controls. Poly C 21-28 interferon alpha 1 Homo sapiens 37-40 3494192-5 1987 Exposure of cells to TNF enhanced IFN-beta 2 (but not IFN-beta 1) mRNA expression in response to poly(I).poly(C), an IFN inducer which is also known to stimulate FS-4 cell growth. Poly C 105-112 tumor necrosis factor Homo sapiens 21-24 3494192-5 1987 Exposure of cells to TNF enhanced IFN-beta 2 (but not IFN-beta 1) mRNA expression in response to poly(I).poly(C), an IFN inducer which is also known to stimulate FS-4 cell growth. Poly C 105-112 interleukin 6 Homo sapiens 34-44 3494192-5 1987 Exposure of cells to TNF enhanced IFN-beta 2 (but not IFN-beta 1) mRNA expression in response to poly(I).poly(C), an IFN inducer which is also known to stimulate FS-4 cell growth. Poly C 105-112 interferon alpha 1 Homo sapiens 34-37 2430524-0 1986 Depression of cytochrome P-450 and alterations of protein metabolism in mice treated with the interferon inducer polyriboinosinic acid X polyribocytidylic acid. Poly C 137-159 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 14-30 3745988-1 1986 The synthetic polyribonucleotide polyinosinate:polycytidylate [poly(I):poly(C)] was used to induce interferon (IFN) production in a rat leiomyosarcoma cell line. Poly C 71-78 interferon alpha 1 Homo sapiens 111-114 3081254-4 1986 In contrast, the lethal effect of the combination of IFN-gamma and poly(I).poly(C) was synergistic and this regimen produced a 40 to 80% reduction in colony formation. Poly C 75-82 interferon gamma Homo sapiens 53-62 3081254-6 1986 The concentration of the dsRNAs producing a 50% decrease in cell viability in combination with IFN-gamma (100 units/ml) was 6 micrograms/ml for poly(I).poly(C), 1 microgram/ml for poly(A).poly(U), 3 ng/ml for poly(ICLC), and 16 micrograms/ml for rIn.r(C13,U)n. DNA, RNA, and protein synthesis in IFN-gamma and poly(I).poly(C)-treated cells were reduced in a dose-dependent manner. Poly C 152-159 interferon gamma Homo sapiens 95-104 2428755-9 1986 The excellent IFN inducer, poly I:C, at the tested dose range (0.03-3.0 mg/kg), displayed only a relatively weak adjuvant activity. Poly C 27-35 interferon alpha 1 Homo sapiens 14-17 2428755-11 1986 This might be related to sufficient induction of IFN by low doses of poly I:C but not by DDA. Poly C 69-77 interferon alpha 1 Homo sapiens 49-52 2985717-0 1985 Induction of human interferon gamma in nylon-column nonadherent human lymphocyte cells by heat-treated poly I:poly C. Poly C 110-116 interferon gamma Homo sapiens 19-35 2985717-3 1985 When nylon-column nonadherent cells (NNA cells) were induced by poly I:poly C which was prepared by heat-treatment, high levels of acid- and heat-labile interferon (IFN) were obtained. Poly C 71-77 interferon alpha 1 Homo sapiens 141-169 6206680-2 1984 A CSF Poly(C)-avid ribonuclease (RNase) activity was determined in serum and CSF of 11 controls and 75 neurological patients (34 multiple sclerosis (MS), 18 infectious processes and 23 other neurological diseases (OND]. Poly C 6-13 colony stimulating factor 2 Homo sapiens 77-80 6712732-3 1984 polyribocytidylic acid (poly IC) on the postnatal development of hepatic cytochrome P-450-linked monooxygenase systems of male rats from birth through early adolescence. Poly C 0-22 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 73-89 6712732-3 1984 polyribocytidylic acid (poly IC) on the postnatal development of hepatic cytochrome P-450-linked monooxygenase systems of male rats from birth through early adolescence. Poly C 24-31 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 73-89 6178587-7 1982 poly(C) competes poorly for the androgen receptor. Poly C 0-7 androgen receptor Mus musculus 32-49 6700582-3 1984 These cells were found to express high levels of human IFN-beta after polyriboinosinic acid-polyribocytidylic acid superinduction or NDV infection; this was a result of coamplification of the IFN-beta gene. Poly C 92-114 interferon beta 1 Homo sapiens 55-63 6322211-0 1984 Depressant effects of the interferon inducer polyriboinosinic:polyribocytidylic acid on cytochrome P-450 hemoproteins. Poly C 62-84 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 88-104 6191776-3 1983 The estrogen receptor was found to interact more strongly with poly(G), poly(U) than with poly(A), poly(C). Poly C 99-105 estrogen receptor 1 Homo sapiens 4-21 6856471-1 1983 Northern blot analysis reveals that total RNA from human fibroblastoid cells (MG 63) induced with poly(I).poly(C) under conditions of IFN-beta production, contains predominantly a +/- 1,200 nucleotide long poly (A) mRNA (mRNA.M) which hybridizes with a Hu IFN-beta cDNA specific probe. Poly C 106-112 interferon beta 1 Homo sapiens 134-142 6856471-1 1983 Northern blot analysis reveals that total RNA from human fibroblastoid cells (MG 63) induced with poly(I).poly(C) under conditions of IFN-beta production, contains predominantly a +/- 1,200 nucleotide long poly (A) mRNA (mRNA.M) which hybridizes with a Hu IFN-beta cDNA specific probe. Poly C 106-112 interferon beta 1 Homo sapiens 256-264 6838554-0 1983 Induction of human leukocyte interferon by heat-treated poly I: poly C. Poly C 64-70 interferon alpha 1 Homo sapiens 29-39 6838554-1 1983 Synthetic double stranded RNA (poly I: poly C) was prepared from polyinosinic acid (poly I) and polycytidylic acid (poly C) by heat-treated followed by gradual cooling, and was used for induction of human leukocyte interferon (IFN). Poly C 39-45 interferon alpha 1 Homo sapiens 205-231 6838554-1 1983 Synthetic double stranded RNA (poly I: poly C) was prepared from polyinosinic acid (poly I) and polycytidylic acid (poly C) by heat-treated followed by gradual cooling, and was used for induction of human leukocyte interferon (IFN). Poly C 96-114 interferon alpha 1 Homo sapiens 205-231 6838554-2 1983 When poly I: poly C solution was heated at 37 - 65 degrees C for 30 minutes, high activity of human IFN (10,000 - 60,000 i. u./ml) was obtained. Poly C 13-19 interferon alpha 1 Homo sapiens 100-103 6838554-3 1983 In this system, the optimum molecular weight of poly I: poly C to induce IFN was 12.6 - 17.6 S. The properties of induced IFN were heat- and acid- stable, and it was neutralized with anti-IFN alpha serum. Poly C 56-62 interferon alpha 1 Homo sapiens 73-76 6838554-3 1983 In this system, the optimum molecular weight of poly I: poly C to induce IFN was 12.6 - 17.6 S. The properties of induced IFN were heat- and acid- stable, and it was neutralized with anti-IFN alpha serum. Poly C 56-62 interferon alpha 1 Homo sapiens 122-125 6838554-3 1983 In this system, the optimum molecular weight of poly I: poly C to induce IFN was 12.6 - 17.6 S. The properties of induced IFN were heat- and acid- stable, and it was neutralized with anti-IFN alpha serum. Poly C 56-62 interferon alpha 1 Homo sapiens 188-197 6956764-14 1982 poly C-stimulated PEMM caused 31--56% lysis of syngeneic EL-4 and allogeneic L-929, NS-1, and YAC-1 tumor cells in vitro but was not cytotoxic for normal cells. Poly C 0-6 epilepsy 4 Mus musculus 57-82 6956764-14 1982 poly C-stimulated PEMM caused 31--56% lysis of syngeneic EL-4 and allogeneic L-929, NS-1, and YAC-1 tumor cells in vitro but was not cytotoxic for normal cells. Poly C 0-6 ADP-ribosyltransferase 1 Mus musculus 94-99 6180119-2 1982 poly (C)-induced human diploid fibroblasts (FS-4) and from several similarly induced human-mouse somatic cell hybrids by electrophoresis through agarose-CH3HgOH tube gels led to the detection of at least five translationally active human IFN-beta mRNA species. Poly C 0-8 interferon beta 1 Homo sapiens 238-246 6180744-0 1982 Sequential administrations of polyriboinosinic acid and polyribocytidylic acid induce interferon and depress the hepatic cytochrome P-450-dependent monooxygenase system. Poly C 56-78 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 121-137 6712731-3 1984 polyribocytidylic acid (poly IC), are known to depress hepatic cytochrome P-450-dependent monooxygenase systems and the induction of these systems by phenobarbital (PB) and 3-methylcholanthrene (MC) in mature male rats. Poly C 0-22 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 63-79 6712731-3 1984 polyribocytidylic acid (poly IC), are known to depress hepatic cytochrome P-450-dependent monooxygenase systems and the induction of these systems by phenobarbital (PB) and 3-methylcholanthrene (MC) in mature male rats. Poly C 24-31 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 63-79 6306284-2 1983 The optimal conditions for induction of human IFN and of its mRNA in these transformants resembled those needed for mouse IFN: high concentrations of DEAE-dextran and low concentrations of polyriboinosinic acid-polyribocytidylic acid. Poly C 211-233 interferon alpha 1 Homo sapiens 46-49 6306284-2 1983 The optimal conditions for induction of human IFN and of its mRNA in these transformants resembled those needed for mouse IFN: high concentrations of DEAE-dextran and low concentrations of polyriboinosinic acid-polyribocytidylic acid. Poly C 211-233 interferon alpha 1 Homo sapiens 122-125 6187846-1 1983 Systemic inoculation of the interferon (IFN) inducer polyinosinic-polycytidylic polyribonucleotide (poly I:poly C) into CBA/J mice produces a significant decrease in the number of thoracic duct lymphocytes (TDL) collected 6 to 22 hr after injection. Poly C 107-113 interferon alpha 1 Homo sapiens 40-43 6187846-5 1983 2) Pretreatment of mice with sheep anti-murine IFN serum can block this effect of poly I:poly C. Poly C 89-95 interferon alpha 1 Homo sapiens 47-50 6165879-7 1981 The presence of polyC during preincubation protected rho+ activity but produced substantial inactivation of rho-115 ATPase. Poly C 16-21 ATPase Escherichia coli 116-122 6452899-5 1981 The purified rho has an ATPase specific activity of 32 nmol of Pi released min-1 microgram-1 when poly(cytidylic acid) is used as a cofactor, and it functions effectively in termination of T7 DNA transcription. Poly C 98-118 ATPase Escherichia coli 24-30 6165879-9 1981 Concentrations of polyC between 625 ng/ml and 100 micrograms/ml yielded the same extent of rho-115 ATPase inactivation during preincubation at 45 degrees C. Thermal inactivation of rho-115 ATPase by polyC was halted by shifting preincubation temperature from 45 degrees C to 35 degrees C, indicating that polyC-induced destabilization of rho-115 was irreversible. Poly C 18-23 ATPase Escherichia coli 99-105 6165879-9 1981 Concentrations of polyC between 625 ng/ml and 100 micrograms/ml yielded the same extent of rho-115 ATPase inactivation during preincubation at 45 degrees C. Thermal inactivation of rho-115 ATPase by polyC was halted by shifting preincubation temperature from 45 degrees C to 35 degrees C, indicating that polyC-induced destabilization of rho-115 was irreversible. Poly C 18-23 ATPase Escherichia coli 189-195 6165879-9 1981 Concentrations of polyC between 625 ng/ml and 100 micrograms/ml yielded the same extent of rho-115 ATPase inactivation during preincubation at 45 degrees C. Thermal inactivation of rho-115 ATPase by polyC was halted by shifting preincubation temperature from 45 degrees C to 35 degrees C, indicating that polyC-induced destabilization of rho-115 was irreversible. Poly C 199-204 ATPase Escherichia coli 189-195 640718-3 1978 Thus, the effect of methylated bovine serum albumin on the antibody production to poly(ADP-ribose) resembled the case of poly(I).poly(C) and was different from the case of single stranded DNA. Poly C 129-136 albumin Mus musculus 38-51 570180-2 1978 The stimulatory effect on interferon production was not expressed in polyriboinosinic acid:polycytidylic acid-induced interferon. Poly C 91-109 interferon Gallus gallus 118-128 687577-8 1978 At saturation of poly(I).poly(C) by Fab fragments, the number of binding sites of ethidium bromide is only reduced by a factor of two. Poly C 25-32 FA complementation group B Homo sapiens 36-39 6750198-4 1982 poly C or LPS released a macrophage cytotoxin (MCT) that rapidly bound to syngeneic (EL 4) or allogeneic (NS-1, YAC-1) tumor cells but did not bind to normal splenocytes. Poly C 0-6 ADP-ribosyltransferase 1 Mus musculus 112-117 289438-4 1979 Simultaneous treatment of MI cells with the anti-interferon serum and copolymer of polyinosine and polycytidylic acids and D-factor abolished the enhancing effect of copolymer of polyinosine and polycytidylic acids on the action of the D-factor. Poly C 99-118 leukemia inhibitory factor Mus musculus 236-244 289438-4 1979 Simultaneous treatment of MI cells with the anti-interferon serum and copolymer of polyinosine and polycytidylic acids and D-factor abolished the enhancing effect of copolymer of polyinosine and polycytidylic acids on the action of the D-factor. Poly C 195-214 leukemia inhibitory factor Mus musculus 123-131 289438-4 1979 Simultaneous treatment of MI cells with the anti-interferon serum and copolymer of polyinosine and polycytidylic acids and D-factor abolished the enhancing effect of copolymer of polyinosine and polycytidylic acids on the action of the D-factor. Poly C 195-214 leukemia inhibitory factor Mus musculus 236-244 687577-6 1978 The complexes between poly(I).poly(C) and Fab fragments interact with ethidium bromide. Poly C 30-36 FA complementation group B Homo sapiens 42-45 940771-2 1976 poly C, have been determined by potentiometric titration as a function of either ionic strength (Na+) or Mg2+ concentration. Poly C 0-6 mucin 7, secreted Homo sapiens 105-108 188983-8 1977 There were about 170 nucleotides in the poly (C) tract of the SAT1-7 RNA compared with around 100 in the SAT1-82 RNA. Poly C 40-48 diamine acetyltransferase 1 Mesocricetus auratus 62-68 188983-8 1977 There were about 170 nucleotides in the poly (C) tract of the SAT1-7 RNA compared with around 100 in the SAT1-82 RNA. Poly C 40-48 diamine acetyltransferase 1 Mesocricetus auratus 62-66 1259951-6 1976 Using thermodynanic parameters obtained from circular dichroism (CD) and uv absorbance melting curves, the following rate constants k (at 20 degrees C, 1.05 M ionic strength, pH 7) and activation enthalpies EA were calculated for poly (C): helix formation kR = 1.11 X 10(-7) s-1 (EAR = 2.6 kcal); helix dissociation kD = 2.1 X 10(6) s-1 (EAD = 11.9 kcal). Poly C 230-237 nuclear receptor subfamily 2 group F member 6 Homo sapiens 280-287 49986-3 1975 Partially thiolated polycytidylic acids (MPC I-III, containing 1.7%, 3.5%, and 8.6% 5-mercaptocytidylate units, respectively) inhibited the DNA-polymerase of Friend leukemia virus (FVL) in the endogenic reaction as well as in the presence of poly rA-(dT)14 or poly (dA-dT) templates; the inhibitory activities were directly related to the percent of tholation. Poly C 20-39 coagulation factor V Homo sapiens 181-184 1112795-8 1975 It also cleaved other substrates of RNase A such as 5"-(3"-cytidylyl)-guanosine, 5"-(3"-uridylyl)-guanosine, and polycytidylic acid. Poly C 113-131 ribonuclease A family member 1, pancreatic Homo sapiens 36-43 764866-1 1976 Phage Qbeta RNA replicase consists of four nonidentical subunits three of which are required for poly(C)-directed synthesis of poly(G): a phage-coded polypeptide and the two host-supplied protein biosynthesis elongation factors EF-Tu and EF-Ts. Poly C 97-104 Tu translation elongation factor, mitochondrial Homo sapiens 228-233 764866-1 1976 Phage Qbeta RNA replicase consists of four nonidentical subunits three of which are required for poly(C)-directed synthesis of poly(G): a phage-coded polypeptide and the two host-supplied protein biosynthesis elongation factors EF-Tu and EF-Ts. Poly C 97-104 Ts translation elongation factor, mitochondrial Homo sapiens 238-243 33724572-3 2021 Here, we demonstrate that transcription of RORgamma is activated by heterogeneous nuclear ribonucleoprotein K (hnRNP K) via the poly(C) motif within its proximal promoter. Poly C 128-135 heterogeneous nuclear ribonucleoprotein K Homo sapiens 68-109 33827951-9 2021 We further uncovered that knockout of FUS abolishes the ability to form SGs upon CVB3 infection or polyinosinic:polycytidylic acid (polyIC) treatment. Poly C 112-130 FUS RNA binding protein Homo sapiens 38-41 33684425-4 2021 In Experiment 2, rats were neonatally treated with saline or the immune system stimulant polyinosinic:polycytidylic acid (Poly I:C) from P5-7. Poly C 102-120 cyclin-dependent kinase inhibitor 1C Rattus norvegicus 137-141 34039638-6 2021 Mkp-1 -/- bone marrow-derived macrophages (BMDM) produced higher levels of IFN-beta mRNA and protein than did wild-type BMDM upon treatment with LPS, E. coli, polyinosinic:polycytidylic acid, and herring sperm DNA. Poly C 172-190 dual specificity phosphatase 1 Mus musculus 0-5 34028652-7 2021 Polyinosinic: polycytidylic acid (poly [I:C])-stimulated macrophage cells and 10-7 M 1,25 OH-vitamin D3 significantly decreased gene expression of ICAM1, TLR3, IL6, IL8, and TNFalpha (P < 0.0001). Poly C 14-32 intercellular adhesion molecule 1 Mus musculus 147-152 34028652-7 2021 Polyinosinic: polycytidylic acid (poly [I:C])-stimulated macrophage cells and 10-7 M 1,25 OH-vitamin D3 significantly decreased gene expression of ICAM1, TLR3, IL6, IL8, and TNFalpha (P < 0.0001). Poly C 14-32 toll-like receptor 3 Mus musculus 154-158 34028652-7 2021 Polyinosinic: polycytidylic acid (poly [I:C])-stimulated macrophage cells and 10-7 M 1,25 OH-vitamin D3 significantly decreased gene expression of ICAM1, TLR3, IL6, IL8, and TNFalpha (P < 0.0001). Poly C 14-32 interleukin 6 Mus musculus 160-163 34028652-7 2021 Polyinosinic: polycytidylic acid (poly [I:C])-stimulated macrophage cells and 10-7 M 1,25 OH-vitamin D3 significantly decreased gene expression of ICAM1, TLR3, IL6, IL8, and TNFalpha (P < 0.0001). Poly C 14-32 chemokine (C-X-C motif) ligand 15 Mus musculus 165-168 34028652-7 2021 Polyinosinic: polycytidylic acid (poly [I:C])-stimulated macrophage cells and 10-7 M 1,25 OH-vitamin D3 significantly decreased gene expression of ICAM1, TLR3, IL6, IL8, and TNFalpha (P < 0.0001). Poly C 14-32 tumor necrosis factor Mus musculus 174-182 33921475-5 2021 We found that co-culture of iDCs with differentially activated LAD2 MCs in serum-containing media significantly modulated polyinosinic:polycytidylic acid (poly I:C)-elicited DC maturation as determined through the surface expression of the maturation markers CD80, CD83, CD86, and human leukocyte antigen(HLA)-DR. Once iDCs were generated in serum-free conditions, they became refractory to the maturation with poly I:C, and the LAD2 MC modulatory potential was minimized. Poly C 135-153 CD80 molecule Homo sapiens 259-263 33921475-5 2021 We found that co-culture of iDCs with differentially activated LAD2 MCs in serum-containing media significantly modulated polyinosinic:polycytidylic acid (poly I:C)-elicited DC maturation as determined through the surface expression of the maturation markers CD80, CD83, CD86, and human leukocyte antigen(HLA)-DR. Once iDCs were generated in serum-free conditions, they became refractory to the maturation with poly I:C, and the LAD2 MC modulatory potential was minimized. Poly C 135-153 CD83 molecule Homo sapiens 265-269 33921475-5 2021 We found that co-culture of iDCs with differentially activated LAD2 MCs in serum-containing media significantly modulated polyinosinic:polycytidylic acid (poly I:C)-elicited DC maturation as determined through the surface expression of the maturation markers CD80, CD83, CD86, and human leukocyte antigen(HLA)-DR. Once iDCs were generated in serum-free conditions, they became refractory to the maturation with poly I:C, and the LAD2 MC modulatory potential was minimized. Poly C 135-153 CD86 molecule Homo sapiens 271-275 33724572-3 2021 Here, we demonstrate that transcription of RORgamma is activated by heterogeneous nuclear ribonucleoprotein K (hnRNP K) via the poly(C) motif within its proximal promoter. Poly C 128-135 heterogeneous nuclear ribonucleoprotein K Homo sapiens 111-118 33046534-3 2021 Here, we show that immunotherapy with a ligand of Toll-like receptor-3 (TLR3), polyinosinic:polycytidylic acid (pIC), restores the deficient response to chemotherapy of tumors lacking ANXA1 developing in immunocompetent mice or that of normal cancers growing in FPR1-deficient mice. Poly C 92-110 toll-like receptor 3 Mus musculus 50-70 33557113-3 2021 Therefore, in the present study, we examined the effect of MIA induced by polyinosinic:polycytidylic acid (Poly I:C) on the CX3CL1-CX3CR1 and CD200-CD200R axes, microglial trajectory (MhcII, Cd40, iNos, Il-1beta, Tnf-alpha, Il-6, Arg1, Igf-1, Tgf-beta and Il-4), and schizophrenia-like behaviour in adult male offspring of Sprague-Dawley rats. Poly C 87-105 C-X3-C motif chemokine ligand 1 Rattus norvegicus 124-130 33557113-3 2021 Therefore, in the present study, we examined the effect of MIA induced by polyinosinic:polycytidylic acid (Poly I:C) on the CX3CL1-CX3CR1 and CD200-CD200R axes, microglial trajectory (MhcII, Cd40, iNos, Il-1beta, Tnf-alpha, Il-6, Arg1, Igf-1, Tgf-beta and Il-4), and schizophrenia-like behaviour in adult male offspring of Sprague-Dawley rats. Poly C 87-105 Cd200 molecule Rattus norvegicus 142-147 33046534-3 2021 Here, we show that immunotherapy with a ligand of Toll-like receptor-3 (TLR3), polyinosinic:polycytidylic acid (pIC), restores the deficient response to chemotherapy of tumors lacking ANXA1 developing in immunocompetent mice or that of normal cancers growing in FPR1-deficient mice. Poly C 92-110 toll-like receptor 3 Mus musculus 72-76 33046534-3 2021 Here, we show that immunotherapy with a ligand of Toll-like receptor-3 (TLR3), polyinosinic:polycytidylic acid (pIC), restores the deficient response to chemotherapy of tumors lacking ANXA1 developing in immunocompetent mice or that of normal cancers growing in FPR1-deficient mice. Poly C 92-110 annexin A1 Mus musculus 184-189 33046534-3 2021 Here, we show that immunotherapy with a ligand of Toll-like receptor-3 (TLR3), polyinosinic:polycytidylic acid (pIC), restores the deficient response to chemotherapy of tumors lacking ANXA1 developing in immunocompetent mice or that of normal cancers growing in FPR1-deficient mice. Poly C 92-110 formyl peptide receptor 1 Mus musculus 262-266 33452755-4 2021 Here, we found that simvastatin decreased polyinosinic-polycytidylic acid [poly(I:C)]-induced expression of antiviral interferon (IFN)-beta and IFN-stimulated genes (ISGs) in the bronchoalveolar lavage fluid (BALF) and lungs of mice with high-fat diet-induced hyperlipidemia. Poly C 54-73 interferon alpha Mus musculus 118-139 33154038-7 2020 In MRL/Mp and IL-10-/- mice, AIP is induced by repeated polyinosinic:polycytidylic acid injection. Poly C 69-87 interleukin 10 Mus musculus 14-19 33387195-5 2021 RFLS was stimulated with Toll-like receptor 3 (TLR3) ligand polyinosinic:polycytidylic acid (poly I:C), a synthetic double-stranded RNA mimetic. Poly C 73-91 toll like receptor 3 Homo sapiens 25-45 33387195-5 2021 RFLS was stimulated with Toll-like receptor 3 (TLR3) ligand polyinosinic:polycytidylic acid (poly I:C), a synthetic double-stranded RNA mimetic. Poly C 73-91 toll like receptor 3 Homo sapiens 47-51 33035644-6 2020 Expression of IFIT5 was significantly up-regulated following Newcastle disease virus (NDV)-, polyinosinic:polycytidylic acid [poly (I:C)]-, and poly(deoxyadenylic-thymidylic)[poly (dA:dT)]-triggered antiviral immune response. Poly C 106-124 interferon induced protein with tetratricopeptide repeats 5 Homo sapiens 14-19 33087502-8 2020 Furthermore, HSA also inhibited polyinosinic:polycytidylic acid- and lipopolysaccharide-induced interferon regulatory factor 3 phosphorylation and TIR domain-containing adapter-inducing interferon-beta-mediated responses, which are exclusive of endosomal TLR3 and TLR4 signaling, respectively. Poly C 45-63 interferon regulatory factor 3 Homo sapiens 96-126 32979613-7 2020 The sandwich ELISA effectively detected an increased IFN-alpha production in chicken macrophage cells stimulated by polyinosinic:polycytidylic acid (poly I:C), and its minimum detectable level was about 25 pg/mL. Poly C 129-147 interferon Gallus gallus 53-62 33087502-8 2020 Furthermore, HSA also inhibited polyinosinic:polycytidylic acid- and lipopolysaccharide-induced interferon regulatory factor 3 phosphorylation and TIR domain-containing adapter-inducing interferon-beta-mediated responses, which are exclusive of endosomal TLR3 and TLR4 signaling, respectively. Poly C 45-63 toll like receptor 3 Homo sapiens 255-259 33087502-8 2020 Furthermore, HSA also inhibited polyinosinic:polycytidylic acid- and lipopolysaccharide-induced interferon regulatory factor 3 phosphorylation and TIR domain-containing adapter-inducing interferon-beta-mediated responses, which are exclusive of endosomal TLR3 and TLR4 signaling, respectively. Poly C 45-63 toll like receptor 4 Homo sapiens 264-268 32454326-10 2020 We functionally challenged ovaries in vitro, by polyinosinic:polycytidylic acid (poly I:C) and LPS, known to activate TLR3 and TLR4, respectively, and found a tendency for increased IL-6 production, which was particular evident in the LPS-treated group. Poly C 61-79 toll like receptor 3 Homo sapiens 118-122 32923700-7 2020 We showed stimulation of polyinosinic:polycytidylic acid (poly I:C), which led BEAS-2B to produce interferon (IFN)-beta. Poly C 38-56 IFN1@ Homo sapiens 98-119 32492632-7 2020 Pretreatment with IFNgamma robustly enhanced anti-viral gene expression induced by the viral mimetic polyinosinic: polycytidylic acid (PIC), and this potentiating effect of IFNgamma was markedly attenuated by inhibitors of DNL. Poly C 115-133 interferon gamma Rattus norvegicus 18-26 32492632-7 2020 Pretreatment with IFNgamma robustly enhanced anti-viral gene expression induced by the viral mimetic polyinosinic: polycytidylic acid (PIC), and this potentiating effect of IFNgamma was markedly attenuated by inhibitors of DNL. Poly C 115-133 interferon gamma Rattus norvegicus 173-181 32492632-7 2020 Pretreatment with IFNgamma robustly enhanced anti-viral gene expression induced by the viral mimetic polyinosinic: polycytidylic acid (PIC), and this potentiating effect of IFNgamma was markedly attenuated by inhibitors of DNL. Poly C 135-138 interferon gamma Rattus norvegicus 18-26 32492632-7 2020 Pretreatment with IFNgamma robustly enhanced anti-viral gene expression induced by the viral mimetic polyinosinic: polycytidylic acid (PIC), and this potentiating effect of IFNgamma was markedly attenuated by inhibitors of DNL. Poly C 135-138 interferon gamma Rattus norvegicus 173-181 33086712-4 2020 We demonstrated that polyinosinic:polycytidylic acid (poly (I:C)) stimulation and viral infection (vesicular stomatitis (VSV) or porcine reproductive and respiratory syndrome virus (PRRSV)) induce expression of porTRIM26, whereas knock-down expression of porTRIM26 promotes interferon (IFN)- production after poly (I:C) stimulation and virus infection (VSV or PRRSV). Poly C 34-52 interferon alpha 1 Homo sapiens 274-290 32829711-0 2020 The prenatal challenge with lipopolysaccharide and polyinosinic:polycytidylic acid disrupts CX3CL1-CX3CR1 and CD200-CD200R signalling in the brains of male rat offspring: a link to schizophrenia-like behaviours. Poly C 64-82 C-X3-C motif chemokine ligand 1 Rattus norvegicus 92-98 32829711-0 2020 The prenatal challenge with lipopolysaccharide and polyinosinic:polycytidylic acid disrupts CX3CL1-CX3CR1 and CD200-CD200R signalling in the brains of male rat offspring: a link to schizophrenia-like behaviours. Poly C 64-82 C-X3-C motif chemokine receptor 1 Rattus norvegicus 99-105 32829711-0 2020 The prenatal challenge with lipopolysaccharide and polyinosinic:polycytidylic acid disrupts CX3CL1-CX3CR1 and CD200-CD200R signalling in the brains of male rat offspring: a link to schizophrenia-like behaviours. Poly C 64-82 Cd200 molecule Rattus norvegicus 110-115 32824595-3 2020 Of the various TLR ligands examined, the TLR3-specific ligand polyinosinic:polycytidylic acid (poly I:C), significantly induced TNF production and the upregulation of other TLR transcripts, in particular, TLR2. Poly C 75-93 toll-like receptor 2 Mus musculus 15-18 32824595-3 2020 Of the various TLR ligands examined, the TLR3-specific ligand polyinosinic:polycytidylic acid (poly I:C), significantly induced TNF production and the upregulation of other TLR transcripts, in particular, TLR2. Poly C 75-93 toll-like receptor 3 Mus musculus 41-45 32824595-3 2020 Of the various TLR ligands examined, the TLR3-specific ligand polyinosinic:polycytidylic acid (poly I:C), significantly induced TNF production and the upregulation of other TLR transcripts, in particular, TLR2. Poly C 75-93 tumor necrosis factor Mus musculus 128-131 32824595-3 2020 Of the various TLR ligands examined, the TLR3-specific ligand polyinosinic:polycytidylic acid (poly I:C), significantly induced TNF production and the upregulation of other TLR transcripts, in particular, TLR2. Poly C 75-93 toll-like receptor 2 Mus musculus 41-44 32824595-3 2020 Of the various TLR ligands examined, the TLR3-specific ligand polyinosinic:polycytidylic acid (poly I:C), significantly induced TNF production and the upregulation of other TLR transcripts, in particular, TLR2. Poly C 75-93 toll-like receptor 2 Mus musculus 205-209 32454326-10 2020 We functionally challenged ovaries in vitro, by polyinosinic:polycytidylic acid (poly I:C) and LPS, known to activate TLR3 and TLR4, respectively, and found a tendency for increased IL-6 production, which was particular evident in the LPS-treated group. Poly C 61-79 toll like receptor 4 Homo sapiens 127-131 32454326-10 2020 We functionally challenged ovaries in vitro, by polyinosinic:polycytidylic acid (poly I:C) and LPS, known to activate TLR3 and TLR4, respectively, and found a tendency for increased IL-6 production, which was particular evident in the LPS-treated group. Poly C 61-79 interleukin 6 Homo sapiens 182-186 32504419-3 2020 By using a previously established mouse model of depression induced by combined delivery of IFN-alpha and polyinosinic:polycytidylic acid (poly(I:C)), a TLR3 agonist, we provide evidence that IFN-alpha and poly(I:C) reduce apical dendritic spine density in the hippocampal CA1 area ex vivo via mechanisms involving decreased TrkB signaling. Poly C 119-137 toll-like receptor 3 Mus musculus 153-157 32641167-3 2020 Polyinosinic:polycytidylic acid (pIC) mimics viral infections through binding to pattern recognition receptors (e.g. TLR-3). Poly C 13-31 toll-like receptor 3 Mus musculus 117-122 32583610-4 2020 In normal human keratinocytes in vitro, TSLP was induced by polyinosinic:polycytidylic acid (Poly:IC), tumor necrosis factor (TNF)-alpha, and interleukin (IL)-4 and then quantified by ELISA in supernatants. Poly C 73-91 thymic stromal lymphopoietin Homo sapiens 40-44 32768236-7 2020 Host cell poly(C) binding protein 2 (PCBP2) was determined to bind and interact with PLP1. Poly C 10-17 poly(rC) binding protein 2 Homo sapiens 37-42 32768236-7 2020 Host cell poly(C) binding protein 2 (PCBP2) was determined to bind and interact with PLP1. Poly C 10-17 proteolipid protein 1 Homo sapiens 85-89 32504419-3 2020 By using a previously established mouse model of depression induced by combined delivery of IFN-alpha and polyinosinic:polycytidylic acid (poly(I:C)), a TLR3 agonist, we provide evidence that IFN-alpha and poly(I:C) reduce apical dendritic spine density in the hippocampal CA1 area ex vivo via mechanisms involving decreased TrkB signaling. Poly C 119-137 interferon alpha Mus musculus 192-201 32504419-3 2020 By using a previously established mouse model of depression induced by combined delivery of IFN-alpha and polyinosinic:polycytidylic acid (poly(I:C)), a TLR3 agonist, we provide evidence that IFN-alpha and poly(I:C) reduce apical dendritic spine density in the hippocampal CA1 area ex vivo via mechanisms involving decreased TrkB signaling. Poly C 119-137 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 325-329 32568266-1 2020 Polyinosinic:polycytidylic acid (poly[I:C]) can stimulate Toll-like receptor 3 (TLR3) signaling pathways. Poly C 13-31 toll like receptor 3 Gallus gallus 58-78 32455939-0 2020 Polyinosinic: Polycytidylic Acid and Murine Cytomegalovirus Modulate Expression of Murine IL-10 and IL-21 in White Adipose Tissue. Poly C 14-32 interleukin 10 Mus musculus 90-95 32455939-0 2020 Polyinosinic: Polycytidylic Acid and Murine Cytomegalovirus Modulate Expression of Murine IL-10 and IL-21 in White Adipose Tissue. Poly C 14-32 interleukin 21 Mus musculus 100-105 32455939-3 2020 We investigated whether viral stimuli, polyinosinic: polycytidylic acid (poly(I:C)) or whole replicative murine cytomegalovirus (MCMV), could stimulate the expression of IL-10 in murine WAT using in vivo and ex vivo approaches. Poly C 53-71 interleukin 10 Homo sapiens 170-175 32568266-1 2020 Polyinosinic:polycytidylic acid (poly[I:C]) can stimulate Toll-like receptor 3 (TLR3) signaling pathways. Poly C 13-31 toll like receptor 3 Gallus gallus 80-84 31907279-3 2020 Here, we demonstrate that heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a key regulator that activates Dbp transcription via the poly(C) motif within its proximal promoter. Poly C 138-145 heterogeneous nuclear ribonucleoprotein K Homo sapiens 26-67 32034064-6 2020 Treatment of BAFF-RFP mice with polyinosinic:polycytidylic acid increased BAFF expression in splenic Ly6Chi inflammatory MOs, CD11bhi activated NK subset, and in bone marrow myeloid precursors. Poly C 45-63 tumor necrosis factor (ligand) superfamily, member 13b Mus musculus 13-17 32273347-6 2020 RESULTS: In vitro-generated CD103+ cDC1s produced cDC1-associated factors such as interleukin-12p70 and CXCL10, and demonstrated antigen cross-presentation activity on stimulation with the toll-like receptor 3 agonist polyinosinic:polycytidylic acid (poly I:C). Poly C 231-249 integrin alpha E, epithelial-associated Mus musculus 28-33 32273347-6 2020 RESULTS: In vitro-generated CD103+ cDC1s produced cDC1-associated factors such as interleukin-12p70 and CXCL10, and demonstrated antigen cross-presentation activity on stimulation with the toll-like receptor 3 agonist polyinosinic:polycytidylic acid (poly I:C). Poly C 231-249 toll-like receptor 3 Mus musculus 189-209 31907279-3 2020 Here, we demonstrate that heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a key regulator that activates Dbp transcription via the poly(C) motif within its proximal promoter. Poly C 138-145 heterogeneous nuclear ribonucleoprotein K Homo sapiens 69-76 31907279-3 2020 Here, we demonstrate that heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a key regulator that activates Dbp transcription via the poly(C) motif within its proximal promoter. Poly C 138-145 D-box binding PAR bZIP transcription factor Homo sapiens 112-115 31907279-4 2020 Biochemical analyses identified hnRNP K as a specific protein that directly associates with the poly(C) motif in vitro Interestingly, we further confirmed the rhythmic binding of endogenous hnRNP K within the Dbp promoter through chromatin immunoprecipitation as well as the cycling expression of hnRNP K. Poly C 96-103 heterogeneous nuclear ribonucleoprotein K Homo sapiens 32-39 31907279-4 2020 Biochemical analyses identified hnRNP K as a specific protein that directly associates with the poly(C) motif in vitro Interestingly, we further confirmed the rhythmic binding of endogenous hnRNP K within the Dbp promoter through chromatin immunoprecipitation as well as the cycling expression of hnRNP K. Poly C 96-103 heterogeneous nuclear ribonucleoprotein K Homo sapiens 190-197 31907279-4 2020 Biochemical analyses identified hnRNP K as a specific protein that directly associates with the poly(C) motif in vitro Interestingly, we further confirmed the rhythmic binding of endogenous hnRNP K within the Dbp promoter through chromatin immunoprecipitation as well as the cycling expression of hnRNP K. Poly C 96-103 D-box binding PAR bZIP transcription factor Homo sapiens 209-212 31907279-4 2020 Biochemical analyses identified hnRNP K as a specific protein that directly associates with the poly(C) motif in vitro Interestingly, we further confirmed the rhythmic binding of endogenous hnRNP K within the Dbp promoter through chromatin immunoprecipitation as well as the cycling expression of hnRNP K. Poly C 96-103 heterogeneous nuclear ribonucleoprotein K Homo sapiens 190-197 31796819-4 2019 Compared to wild-type, Scga1b1-Foxo3a-/- mice show reduced IFN-alpha, IFN-beta, IFN-lambda2/3 in response to challenge with RV or double-stranded (ds)RNA mimic, Poly Inosinic-polycytidylic acid (Poly I:C) indicating defective dsRNA receptor signaling. Poly C 161-193 forkhead box O3 Mus musculus 31-37 31809875-0 2020 Repeat exposure to polyinosinic:polycytidylic acid induces TLR3 expression via JAK-STAT signaling and synergistically potentiates NFkappaB-RelA signaling in ARPE-19 cells. Poly C 32-50 toll like receptor 3 Homo sapiens 59-63 31809875-0 2020 Repeat exposure to polyinosinic:polycytidylic acid induces TLR3 expression via JAK-STAT signaling and synergistically potentiates NFkappaB-RelA signaling in ARPE-19 cells. Poly C 32-50 nuclear factor kappa B subunit 1 Homo sapiens 130-138 31809875-0 2020 Repeat exposure to polyinosinic:polycytidylic acid induces TLR3 expression via JAK-STAT signaling and synergistically potentiates NFkappaB-RelA signaling in ARPE-19 cells. Poly C 32-50 RELA proto-oncogene, NF-kB subunit Homo sapiens 139-143 31809875-6 2020 We used the human RPE-derived cell line ARPE-19 as a model system for RPE signaling and measured NFkappaB expression and activity in response to TLR3 stimulation with its ligand, polyinosinic:polycytidylic acid (pI:C). Poly C 192-210 nuclear factor kappa B subunit 1 Homo sapiens 97-105 31809875-6 2020 We used the human RPE-derived cell line ARPE-19 as a model system for RPE signaling and measured NFkappaB expression and activity in response to TLR3 stimulation with its ligand, polyinosinic:polycytidylic acid (pI:C). Poly C 192-210 toll like receptor 3 Homo sapiens 145-149 31817146-3 2019 In this study, ginsenoside Rh2 was shown to exert the most effective anti-inflammatory action on thymic stromal lymphopoietin (TSLP) and interleukin 8 in tumor necrosis factor-alpha and polyinosinic: polycytidylic acid induced normal human keratinocytes by inhibiting proinflammatory cytokines at both protein and transcriptional levels. Poly C 200-218 Rh associated glycoprotein Homo sapiens 27-30 31648143-5 2019 Here we hypothesised that maternal immune activation induced in pregnant rats by polyinosinic:polycytidylic acid would alter SST and GAD gene expression as well as increase the density of GAD-positive IWMNs in the adult offspring. Poly C 94-112 somatostatin Rattus norvegicus 125-128 30997942-5 2019 In this study, polyinosinic polycytidylic acid (polyI:C) was used as an activator of TLR3. Poly C 48-55 toll-like receptor 3 Mus musculus 85-89 30997942-8 2019 We observed that exposure to polyI:C induced IFN-gamma+ Foxp3+ iTregs in mouse intestine and in the culture. Poly C 29-36 interferon gamma Mus musculus 45-54 30997942-8 2019 We observed that exposure to polyI:C induced IFN-gamma+ Foxp3+ iTregs in mouse intestine and in the culture. Poly C 29-36 forkhead box P3 Mus musculus 56-61 31648143-5 2019 Here we hypothesised that maternal immune activation induced in pregnant rats by polyinosinic:polycytidylic acid would alter SST and GAD gene expression as well as increase the density of GAD-positive IWMNs in the adult offspring. Poly C 94-112 glutamate decarboxylase 1 Homo sapiens 133-136 31648143-5 2019 Here we hypothesised that maternal immune activation induced in pregnant rats by polyinosinic:polycytidylic acid would alter SST and GAD gene expression as well as increase the density of GAD-positive IWMNs in the adult offspring. Poly C 94-112 glutamate decarboxylase 1 Homo sapiens 188-191 31648143-8 2019 This suggests that our model of maternal immune activation induced by prenatal exposure of rats to polyinosinic:polycytidylic acid during late gestation is able to recapitulate changes in SST but not other GABAergic neuropathologies observed in schizophrenia. Poly C 112-130 somatostatin Rattus norvegicus 188-191 31049957-3 2019 This study aimed to investigate the effect of TLR-3 agonist polyinosinic:polycytidylic acid (Poly I:C) on the expression of inflammatory markers and bone metabolism proteins by human periodontal ligament stem cells (hPDLSCs) compared with TLR-2 agonist Pam3CSK4, which mimics the effect of bacterial lipoproteins. Poly C 73-91 toll like receptor 3 Homo sapiens 46-51 31049957-3 2019 This study aimed to investigate the effect of TLR-3 agonist polyinosinic:polycytidylic acid (Poly I:C) on the expression of inflammatory markers and bone metabolism proteins by human periodontal ligament stem cells (hPDLSCs) compared with TLR-2 agonist Pam3CSK4, which mimics the effect of bacterial lipoproteins. Poly C 73-91 toll like receptor 2 Homo sapiens 239-244 31180720-9 2019 Further investigations suggest that ZIKV NS2B3 impairs polyinosinic:polycytidylic acid-triggered K63-linked polyubiquitination of MITA, thereby subverting the activation of downstream sensors. Poly C 68-86 stimulator of interferon response cGAMP interactor 1 Homo sapiens 130-134 31160492-0 2019 The Poly(C) Motif in the Proximal Promoter Region of the D Site-Binding Protein Gene (Dbp) Drives Its High-Amplitude Oscillation. Poly C 4-11 D-box binding PAR bZIP transcription factor Homo sapiens 57-79 31053970-3 2019 Following injection with polyinosinic:polycytidylic acid, a mimic of viral infection, a robust hepatic innate immune response could be seen involving the TNFalpha pathway at 2 h. Repeated doses led to the adoption of Warburg-like metabolism in the liver as determined by in vivo metabolic imaging, expression analyses, and metabolomics. Poly C 38-56 tumor necrosis factor Homo sapiens 154-162 31160492-0 2019 The Poly(C) Motif in the Proximal Promoter Region of the D Site-Binding Protein Gene (Dbp) Drives Its High-Amplitude Oscillation. Poly C 4-11 D-box binding PAR bZIP transcription factor Homo sapiens 86-89 31160492-3 2019 Here, we demonstrated that the poly(C) motif within the Dbp proximal promoter, in addition to an E-box element, provoked transcriptional activation. Poly C 31-38 D-box binding PAR bZIP transcription factor Homo sapiens 56-59 31160492-4 2019 Furthermore, we generated a cell line with poly(C) deleted to demonstrate the endogenous effect of the poly(C) motif within the Dbp promoter. Poly C 103-110 D-box binding PAR bZIP transcription factor Homo sapiens 128-131 31160492-6 2019 Next, assay for transposase-accessible chromatin (ATAC)-quantitative PCR (qPCR) showed that the poly(C) motif induced greater chromatin accessibility within the region of the Dbp promoter. Poly C 96-103 D-box binding PAR bZIP transcription factor Homo sapiens 175-178 31160492-7 2019 Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms. Poly C 99-105 D-box binding PAR bZIP transcription factor Homo sapiens 68-71 31160492-7 2019 Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms. Poly C 99-105 D-box binding PAR bZIP transcription factor Homo sapiens 205-208 31160492-7 2019 Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms. Poly C 99-105 D-box binding PAR bZIP transcription factor Homo sapiens 205-208 31160492-7 2019 Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms. Poly C 99-106 D-box binding PAR bZIP transcription factor Homo sapiens 68-71 31160492-7 2019 Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms. Poly C 99-106 D-box binding PAR bZIP transcription factor Homo sapiens 205-208 31160492-7 2019 Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms. Poly C 99-106 D-box binding PAR bZIP transcription factor Homo sapiens 205-208 31333667-3 2019 The present study was conducted to determine whether selected lactic acid bacteria (LAB) modulate toll-like receptor 3 (TLR3) agonist polyinosinic:polycytidylic acid (PolyI:C) induced viral response in human intestinal epithelial cells (IECs). Poly C 147-165 toll like receptor 3 Homo sapiens 98-118 31333667-3 2019 The present study was conducted to determine whether selected lactic acid bacteria (LAB) modulate toll-like receptor 3 (TLR3) agonist polyinosinic:polycytidylic acid (PolyI:C) induced viral response in human intestinal epithelial cells (IECs). Poly C 147-165 toll like receptor 3 Homo sapiens 120-124 31110205-1 2019 We have previously identified a novel Aurora-A-mediated Serine 379 (S379) phosphorylation of a poly(C)-binding protein, hnRNPK, the overexpression of which is frequently observed in various cancers. Poly C 95-102 heterogeneous nuclear ribonucleoprotein K Homo sapiens 120-126 31384667-5 2019 Further expansion of tumor-resident CD103+ DCs by injecting the FMS-related tyrosine kinase 3 ligand, the formative cytokine for CD103+ DCs, provided a platform for a booster immunization with the Wilms tumor antigen 1 peptide-based vaccine delivered intraperitoneally with polyriboinosinic:polyribocytidylic acid as an adjuvant. Poly C 291-313 integrin subunit alpha E Homo sapiens 36-41 31384667-5 2019 Further expansion of tumor-resident CD103+ DCs by injecting the FMS-related tyrosine kinase 3 ligand, the formative cytokine for CD103+ DCs, provided a platform for a booster immunization with the Wilms tumor antigen 1 peptide-based vaccine delivered intraperitoneally with polyriboinosinic:polyribocytidylic acid as an adjuvant. Poly C 291-313 fms related receptor tyrosine kinase 3 ligand Homo sapiens 64-100 30387134-9 2019 In conclusion, our studies demonstrate that poly I:C reinforces the potency of cytotoxic chemotherapeutics in PTX-resistant cell line through the TLR3-UNC93B1-IFN-beta signaling pathway, which supplies a novel mechanism of poly I:C for the chemotherapy sensitizing effect in a PTX-resistant tumor. Poly C 223-231 interferon beta 1 Homo sapiens 159-167 30550930-2 2019 Activation of toll-like receptor 3 (TLR3) by polyinosinic:polycytidylic acid (poly(I:C)) produced a rapid proinflammatory response in males that increased alcohol intake over time (Warden et al., 2019). Poly C 58-76 toll-like receptor 3 Mus musculus 14-34 31016183-8 2019 After DHV-1 injection or poly I:C treatment, du SERPINA1 mRNA was up-regulated in the liver and kidney tissues. Poly C 25-33 alpha-1-antitrypsin Anas platyrhynchos 48-56 30387134-3 2019 Herein, we tested whether the TLR3 agonist polyinosinic: polycytidylic acid (poly I:C) can improve chemotherapeutic efficacy in paclitaxel (PTX) resistant cell lines. Poly C 57-75 toll like receptor 3 Homo sapiens 30-34 30387134-3 2019 Herein, we tested whether the TLR3 agonist polyinosinic: polycytidylic acid (poly I:C) can improve chemotherapeutic efficacy in paclitaxel (PTX) resistant cell lines. Poly C 77-85 toll like receptor 3 Homo sapiens 30-34 30387134-7 2019 Moreover, cotreatment of poly I:C and PTX acted synergistically to induce cell apoptosis of HCT-8/PTX via upregulating the expression of TLR3 and its molecular chaperone UNC93B1, assisting in the secretion of IFN-beta. Poly C 25-33 toll like receptor 3 Homo sapiens 137-141 30387134-7 2019 Moreover, cotreatment of poly I:C and PTX acted synergistically to induce cell apoptosis of HCT-8/PTX via upregulating the expression of TLR3 and its molecular chaperone UNC93B1, assisting in the secretion of IFN-beta. Poly C 25-33 unc-93 homolog B1, TLR signaling regulator Homo sapiens 170-177 30387134-7 2019 Moreover, cotreatment of poly I:C and PTX acted synergistically to induce cell apoptosis of HCT-8/PTX via upregulating the expression of TLR3 and its molecular chaperone UNC93B1, assisting in the secretion of IFN-beta. Poly C 25-33 interferon beta 1 Homo sapiens 209-217 30387134-9 2019 In conclusion, our studies demonstrate that poly I:C reinforces the potency of cytotoxic chemotherapeutics in PTX-resistant cell line through the TLR3-UNC93B1-IFN-beta signaling pathway, which supplies a novel mechanism of poly I:C for the chemotherapy sensitizing effect in a PTX-resistant tumor. Poly C 44-52 toll like receptor 3 Homo sapiens 146-150 30387134-9 2019 In conclusion, our studies demonstrate that poly I:C reinforces the potency of cytotoxic chemotherapeutics in PTX-resistant cell line through the TLR3-UNC93B1-IFN-beta signaling pathway, which supplies a novel mechanism of poly I:C for the chemotherapy sensitizing effect in a PTX-resistant tumor. Poly C 44-52 unc-93 homolog B1, TLR signaling regulator Homo sapiens 151-158 30387134-9 2019 In conclusion, our studies demonstrate that poly I:C reinforces the potency of cytotoxic chemotherapeutics in PTX-resistant cell line through the TLR3-UNC93B1-IFN-beta signaling pathway, which supplies a novel mechanism of poly I:C for the chemotherapy sensitizing effect in a PTX-resistant tumor. Poly C 44-52 interferon beta 1 Homo sapiens 159-167 30387134-9 2019 In conclusion, our studies demonstrate that poly I:C reinforces the potency of cytotoxic chemotherapeutics in PTX-resistant cell line through the TLR3-UNC93B1-IFN-beta signaling pathway, which supplies a novel mechanism of poly I:C for the chemotherapy sensitizing effect in a PTX-resistant tumor. Poly C 223-231 toll like receptor 3 Homo sapiens 146-150 30550930-2 2019 Activation of toll-like receptor 3 (TLR3) by polyinosinic:polycytidylic acid (poly(I:C)) produced a rapid proinflammatory response in males that increased alcohol intake over time (Warden et al., 2019). Poly C 58-76 toll-like receptor 3 Mus musculus 36-40 30550931-6 2019 To test the possibility TLR3 activation regulates alcohol consumption, we injected mice with the TLR3 agonist polyinosinic:polycytidylic acid (poly(I:C)) and tested alcohol consumption in an every-other-day two-bottle choice test. Poly C 123-141 toll-like receptor 3 Mus musculus 97-101 30478640-7 2019 RESULTS: DEXI-silenced beta cells exposed to a synthetic double-stranded RNA (polyinosinic:polycytidylic acid [PIC], a by-product of viral replication) showed reduced activation of signal transducer and activator of transcription (STAT) 1 and lower production of proinflammatory chemokines that was preceded by a reduction in IFNbeta levels. Poly C 91-109 Dexi homolog Homo sapiens 9-13 30478640-7 2019 RESULTS: DEXI-silenced beta cells exposed to a synthetic double-stranded RNA (polyinosinic:polycytidylic acid [PIC], a by-product of viral replication) showed reduced activation of signal transducer and activator of transcription (STAT) 1 and lower production of proinflammatory chemokines that was preceded by a reduction in IFNbeta levels. Poly C 91-109 signal transducer and activator of transcription 1 Homo sapiens 181-238 30518569-6 2019 As has been described in other cell types, nc886 bound to PKR in human T cell lysates, preventing PKR phosphorylation by polyinosinic:polycytidylic acid or HIV trans-activation response element RNA in lysates of T cell lines or primary human CD4+ T cells. Poly C 134-152 vault RNA 2-1 Homo sapiens 43-48 30530482-5 2019 Through viral infection, polyinosinic:polycytidylic acid and RIG-I-like receptor factor stimulation upregulated IFN expression, but overexpression of MVP significantly subverted these inductions. Poly C 38-56 interferon phi 1 Danio rerio 112-115 30153047-10 2019 We also observed that ZL0454 treatment blocked polyinosinic:polycytidylic acid-associated expansion of the alpha-SMA1+/COL1A+ myofibroblast population and prevented myofibroblast transition in a coculture system. Poly C 60-78 survival of motor neuron 1, telomeric Homo sapiens 113-117 30590162-4 2019 For the genes related to inflammation, viperin, Mx and Toll like receptor 3 (TLR3), transcription were significantly upregulated by poly I:C in head kidney cells, while viperin was upregulated in liver cells. Poly C 132-140 toll-like receptor 3 Salmo salar 55-75 30590162-4 2019 For the genes related to inflammation, viperin, Mx and Toll like receptor 3 (TLR3), transcription were significantly upregulated by poly I:C in head kidney cells, while viperin was upregulated in liver cells. Poly C 132-140 toll-like receptor 3 Salmo salar 77-81 30723476-6 2018 Treatment with the TLR3 ligand polyinosinic: polycytidylic acid [Poly(I:C)] did not affect GILZ mRNA levels, although GILZ protein expression was decreased. Poly C 45-63 toll like receptor 3 Homo sapiens 19-23 30518569-6 2019 As has been described in other cell types, nc886 bound to PKR in human T cell lysates, preventing PKR phosphorylation by polyinosinic:polycytidylic acid or HIV trans-activation response element RNA in lysates of T cell lines or primary human CD4+ T cells. Poly C 134-152 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 58-61 30363688-7 2018 Using a luciferase assay, the proinflammatory cytokines IL-1beta and TNF, and viral analogue polyinosinic : polycytidylic acid (poly(I : C)) significantly reduced SMAD3 transcriptional activity in human primary myometrial cells. Poly C 108-126 SMAD family member 3 Homo sapiens 163-168 30075247-5 2018 Following poly I:C challenge, the expression levels of TRAF3 and TRAF6 were highest in the kidneys and lowest in the spleen, whereas after infection with V. anguillarum, TRAF6 expression was the highest in the kidneys and lowest in the liver. Poly C 10-18 TNF receptor-associated factor 3 Larimichthys crocea 55-60 30075247-5 2018 Following poly I:C challenge, the expression levels of TRAF3 and TRAF6 were highest in the kidneys and lowest in the spleen, whereas after infection with V. anguillarum, TRAF6 expression was the highest in the kidneys and lowest in the liver. Poly C 10-18 TNF receptor-associated factor 6 Larimichthys crocea 65-70 30224514-5 2018 In this study, we have shown that polyinosinic:polycytidylic acid (polyI:C) and influenza A virus (IAV) infection increased IFN-lambda expression at mRNA and protein levels in primary cultures of normal human bronchial epithelial cells, whereas IL-17A attenuated polyI:C- or IAV-induced IFN-lambda expression. Poly C 47-65 interferon alpha 1 Homo sapiens 124-127 30224514-5 2018 In this study, we have shown that polyinosinic:polycytidylic acid (polyI:C) and influenza A virus (IAV) infection increased IFN-lambda expression at mRNA and protein levels in primary cultures of normal human bronchial epithelial cells, whereas IL-17A attenuated polyI:C- or IAV-induced IFN-lambda expression. Poly C 47-65 interleukin 17A Homo sapiens 245-251 30224514-5 2018 In this study, we have shown that polyinosinic:polycytidylic acid (polyI:C) and influenza A virus (IAV) infection increased IFN-lambda expression at mRNA and protein levels in primary cultures of normal human bronchial epithelial cells, whereas IL-17A attenuated polyI:C- or IAV-induced IFN-lambda expression. Poly C 47-65 interferon alpha 1 Homo sapiens 287-290 29933111-7 2018 Moreover, we found that On-TRAF6 was involved immune response of Nile tilapia following the stimulation with Streptococcus agalactiae and polyinosinic: polycytidylic acid (Poly I:C) when determined by using qPCR. Poly C 172-180 TNF receptor-associated factor 6 Oreochromis niloticus 27-32 30063728-7 2018 We found that addition of the TLR3 agonist, polyinosinic:polycytidylic acid (Poly(I:C)) to either one of the Mincle receptor agonists, TDB or monomycoloyl glycerol (MMG), enhanced monocyte activation, and calves vaccinated with CAF09 containing MMG and Poly(I:C) had increased cell-mediated and humoral immune response compared to CAF01 vaccinated animals. Poly C 57-75 toll like receptor 3 Bos taurus 30-34 30063728-7 2018 We found that addition of the TLR3 agonist, polyinosinic:polycytidylic acid (Poly(I:C)) to either one of the Mincle receptor agonists, TDB or monomycoloyl glycerol (MMG), enhanced monocyte activation, and calves vaccinated with CAF09 containing MMG and Poly(I:C) had increased cell-mediated and humoral immune response compared to CAF01 vaccinated animals. Poly C 57-75 C-type lectin domain family 4 member E Bos taurus 109-115 29866654-0 2018 Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript. Poly C 0-7 poly(rC) binding protein 2 Homo sapiens 24-29 29866654-0 2018 Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript. Poly C 0-7 RUNX family transcription factor 1 Homo sapiens 123-128 29891675-3 2018 We herein report that the poly(C)-binding protein PCBP1 binds to more severely oxidized RNA to activate apoptosis-related reactions. Poly C 26-33 poly(rC) binding protein 1 Homo sapiens 50-55