PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2542091-4	1989	The level of activation of PKC is quite remarkable in the case of the combined stimulation by poly(I):poly(C) and TPA as compared to poly(I):poly(C) alone.	Poly C	141-148	plasminogen activator, tissue type	Homo sapiens	114-117
2557635-2	1989	Here we show that in both human FS-4 and murine L929 cells, steady-state levels of IRF-1 mRNA were increased by treatment with tumor necrosis factor (TNF), interleukin 1 (IL-1), poly(I).poly(C), or IFN-beta.	Poly C	186-192	interferon regulatory factor 1	Mus musculus	83-88
2557635-2	1989	Here we show that in both human FS-4 and murine L929 cells, steady-state levels of IRF-1 mRNA were increased by treatment with tumor necrosis factor (TNF), interleukin 1 (IL-1), poly(I).poly(C), or IFN-beta.	Poly C	186-192	tumor necrosis factor	Mus musculus	127-148
2557635-2	1989	Here we show that in both human FS-4 and murine L929 cells, steady-state levels of IRF-1 mRNA were increased by treatment with tumor necrosis factor (TNF), interleukin 1 (IL-1), poly(I).poly(C), or IFN-beta.	Poly C	186-192	tumor necrosis factor	Mus musculus	150-153
2557635-5	1989	In L929 cells, treatment with poly(I).poly(C) under conditions that failed to induce significant levels of IFN-beta mRNA led to a very low induction of IRF-1 mRNA, but "priming" cells with IFN prior to the addition of poly(I).poly(C) greatly increased both IRF-1 and IFN-beta mRNAs.	Poly C	38-45	interferon regulatory factor 1	Mus musculus	152-157
2557635-5	1989	In L929 cells, treatment with poly(I).poly(C) under conditions that failed to induce significant levels of IFN-beta mRNA led to a very low induction of IRF-1 mRNA, but "priming" cells with IFN prior to the addition of poly(I).poly(C) greatly increased both IRF-1 and IFN-beta mRNAs.	Poly C	38-45	interferon regulatory factor 1	Mus musculus	257-262
2557635-5	1989	In L929 cells, treatment with poly(I).poly(C) under conditions that failed to induce significant levels of IFN-beta mRNA led to a very low induction of IRF-1 mRNA, but "priming" cells with IFN prior to the addition of poly(I).poly(C) greatly increased both IRF-1 and IFN-beta mRNAs.	Poly C	38-45	interferon beta 1, fibroblast	Mus musculus	267-275
2557635-5	1989	In L929 cells, treatment with poly(I).poly(C) under conditions that failed to induce significant levels of IFN-beta mRNA led to a very low induction of IRF-1 mRNA, but "priming" cells with IFN prior to the addition of poly(I).poly(C) greatly increased both IRF-1 and IFN-beta mRNAs.	Poly C	38-44	interferon regulatory factor 1	Mus musculus	152-157
2557635-5	1989	In L929 cells, treatment with poly(I).poly(C) under conditions that failed to induce significant levels of IFN-beta mRNA led to a very low induction of IRF-1 mRNA, but "priming" cells with IFN prior to the addition of poly(I).poly(C) greatly increased both IRF-1 and IFN-beta mRNAs.	Poly C	38-44	interferon regulatory factor 1	Mus musculus	257-262
2557635-5	1989	In L929 cells, treatment with poly(I).poly(C) under conditions that failed to induce significant levels of IFN-beta mRNA led to a very low induction of IRF-1 mRNA, but "priming" cells with IFN prior to the addition of poly(I).poly(C) greatly increased both IRF-1 and IFN-beta mRNAs.	Poly C	38-44	interferon beta 1, fibroblast	Mus musculus	267-275
2502582-3	1989	Coculture of M phi with IFN-gamma and polyinosinic-polycytidylic acid [poly(I):poly(C)] resulted in the reduction of Ia expression in comparison with those cultured without poly(I):poly(C).	Poly C	79-86	interferon gamma	Homo sapiens	24-33
2502582-3	1989	Coculture of M phi with IFN-gamma and polyinosinic-polycytidylic acid [poly(I):poly(C)] resulted in the reduction of Ia expression in comparison with those cultured without poly(I):poly(C).	Poly C	79-85	interferon gamma	Homo sapiens	24-33
2502582-4	1989	Pretreatment of M phi with poly(I):poly(C) or a bacterial lipopolysaccharide (LPS), which is also a potent IFN inducer, in vitro or in vivo, before being exposed to IFN-gamma was also effective in suppressing the Ia expression.	Poly C	35-42	interferon alpha 1	Homo sapiens	107-110
2502585-2	1989	In MNC, poly(I):poly(C) and mismatched poly(I):poly(C) induced IFN-alpha in a dose-dependent manner, whereas poly(ICLC) was unable to do so in concentrations that ranged from 1 to 160 micrograms/ml.	Poly C	16-22	interferon alpha 1	Homo sapiens	63-72
2502585-2	1989	In MNC, poly(I):poly(C) and mismatched poly(I):poly(C) induced IFN-alpha in a dose-dependent manner, whereas poly(ICLC) was unable to do so in concentrations that ranged from 1 to 160 micrograms/ml.	Poly C	47-53	interferon alpha 1	Homo sapiens	63-72
2502585-4	1989	The capacity of poly(I):poly(C) to induce IFN-alpha was reestablished only in monocyte cultures when, prior to the stimulation, the cells were exposed for at least 2 h to supernatants from poly(I):poly(C)-stimulated lymphocyte cultures.	Poly C	24-31	interferon alpha 1	Homo sapiens	42-51
2502585-4	1989	The capacity of poly(I):poly(C) to induce IFN-alpha was reestablished only in monocyte cultures when, prior to the stimulation, the cells were exposed for at least 2 h to supernatants from poly(I):poly(C)-stimulated lymphocyte cultures.	Poly C	197-204	interferon alpha 1	Homo sapiens	42-51
2542091-0	1989	The roles of protein kinase C and cyclic nucleotide dependent kinase in signal transduction in human interferon gamma induction by poly I:poly C.	Poly C	138-144	interferon gamma	Homo sapiens	101-117
2542091-1	1989	The signal transduction mechanisms involved in interferon (IFN) gamma induction in human peripheral mononuclear lymphocyte nylon-nonadherent cells (NNA cells) by stimulation with poly(I):poly(C) are investigated.	Poly C	187-194	interferon gamma	Homo sapiens	47-69
2542091-2	1989	Significant enhancement of IFN gamma production by poly(I):poly(C) is observed in the presence of the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA, a protein kinase C (PKC) activator).	Poly C	59-66	interferon gamma	Homo sapiens	27-36
2542091-2	1989	Significant enhancement of IFN gamma production by poly(I):poly(C) is observed in the presence of the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA, a protein kinase C (PKC) activator).	Poly C	59-66	plasminogen activator, tissue type	Homo sapiens	155-158
2542091-6	1989	Moreover, inhibition experiments using the PKC inhibitor H-7 and cAMP-dependent protein kinase inhibitor H-8 suggest that the mechanism of signal transduction with regard to PKC is involved in stimulation of IFN gamma production in NNA cells by poly(I):poly(C) in the presence of TPA and that along with PKC, cAMP-dependent protein kinase is probably involved in induction of IFN gamma by stimulation with poly(I):poly(C) alone.	Poly C	253-259	interferon gamma	Homo sapiens	208-217
2542091-6	1989	Moreover, inhibition experiments using the PKC inhibitor H-7 and cAMP-dependent protein kinase inhibitor H-8 suggest that the mechanism of signal transduction with regard to PKC is involved in stimulation of IFN gamma production in NNA cells by poly(I):poly(C) in the presence of TPA and that along with PKC, cAMP-dependent protein kinase is probably involved in induction of IFN gamma by stimulation with poly(I):poly(C) alone.	Poly C	253-260	interferon gamma	Homo sapiens	208-217
2647497-0	1989	Production of interferon-beta upon induction with polyinosinic acid:polycytidylic acid during the cell cycle of human fibroblasts.	Poly C	68-86	interferon beta 1	Homo sapiens	14-29
2647497-2	1989	Human fibroblasts were synchronized with mitotic detachment and, at different stages of the cell cycle, poly(I):poly(C) was added for induction of interferon-beta.	Poly C	112-119	interferon beta 1	Homo sapiens	147-162
2647497-1	1989	The production of interferon-beta was examined at various stages of the cell cycle in synchronized and unsynchronized cell populations induced by poly(I):poly(C).	Poly C	154-161	interferon beta 1	Homo sapiens	18-33
2537976-1	1989	Human tumor necrosis factor alpha (TNF-alpha) gene expression can be induced primarily in cells of the monocyte/macrophage lineage by a variety of inducers, including lipopolysaccharide, phorbol esters such as phorbol 12-myristate 13-acetate, and virus or synthetic double-stranded RNA [poly(I).poly(C)].	Poly C	295-302	tumor necrosis factor	Homo sapiens	6-33
2465167-0	1989	Interleukin 1 and poly(rI).poly(rC) induce production of granulocyte CSF, macrophage CSF, and granulocyte-macrophage CSF by human endothelial cells.	Poly C	27-35	interleukin 1 alpha	Homo sapiens	0-13
2465167-0	1989	Interleukin 1 and poly(rI).poly(rC) induce production of granulocyte CSF, macrophage CSF, and granulocyte-macrophage CSF by human endothelial cells.	Poly C	27-35	colony stimulating factor 2	Homo sapiens	69-72
2465167-0	1989	Interleukin 1 and poly(rI).poly(rC) induce production of granulocyte CSF, macrophage CSF, and granulocyte-macrophage CSF by human endothelial cells.	Poly C	27-35	colony stimulating factor 2	Homo sapiens	85-88
2465167-0	1989	Interleukin 1 and poly(rI).poly(rC) induce production of granulocyte CSF, macrophage CSF, and granulocyte-macrophage CSF by human endothelial cells.	Poly C	27-35	colony stimulating factor 2	Homo sapiens	85-88
2465167-5	1989	The kinetics of IL-1-induced CSA release as opposed to poly(rI).poly(rC)-induced release were found to be different, in that poly(rI).poly(rC)-induced CSA production occurred more slowly.	Poly C	64-72	interleukin 1 beta	Homo sapiens	16-20
2465167-5	1989	The kinetics of IL-1-induced CSA release as opposed to poly(rI).poly(rC)-induced release were found to be different, in that poly(rI).poly(rC)-induced CSA production occurred more slowly.	Poly C	134-142	interleukin 1 beta	Homo sapiens	16-20
2465167-7	1989	Using specific immunologic assays, IL-1- as well as poly(rI).poly(rC)-inducible production of granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF, and macrophage CSF was found.	Poly C	61-69	interleukin 1 beta	Homo sapiens	35-39
2465167-7	1989	Using specific immunologic assays, IL-1- as well as poly(rI).poly(rC)-inducible production of granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF, and macrophage CSF was found.	Poly C	61-69	colony stimulating factor 3	Homo sapiens	94-131
2465167-7	1989	Using specific immunologic assays, IL-1- as well as poly(rI).poly(rC)-inducible production of granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF, and macrophage CSF was found.	Poly C	61-69	colony stimulating factor 3	Homo sapiens	133-138
2465167-7	1989	Using specific immunologic assays, IL-1- as well as poly(rI).poly(rC)-inducible production of granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF, and macrophage CSF was found.	Poly C	61-69	colony stimulating factor 2	Homo sapiens	135-138
2465167-7	1989	Using specific immunologic assays, IL-1- as well as poly(rI).poly(rC)-inducible production of granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF, and macrophage CSF was found.	Poly C	61-69	colony stimulating factor 2	Homo sapiens	164-167
2537976-1	1989	Human tumor necrosis factor alpha (TNF-alpha) gene expression can be induced primarily in cells of the monocyte/macrophage lineage by a variety of inducers, including lipopolysaccharide, phorbol esters such as phorbol 12-myristate 13-acetate, and virus or synthetic double-stranded RNA [poly(I).poly(C)].	Poly C	295-302	tumor necrosis factor	Homo sapiens	35-44
2715669-5	1989	Multiple phosphorylated species of a 72-kD protein were labeled in response to poly(I):poly(C) by extracts from IFN-treated cells but not by extracts from control cells.	Poly C	87-94	interferon alpha 1	Homo sapiens	112-115
2607779-8	1989	Survival times of the mice inoculated with the LL-2 cells were prolonged by administrations of an inducer of differentiation, poly(I).poly(C).	Poly C	134-141	peroxiredoxin 2, pseudogene 1	Mus musculus	47-51
2607779-9	1989	We found morphological changes in the peritoneal blastic LL-2 cells to mature macrophage-like cells after the serial administrations of poly(I).poly(C) to the recipient mice.	Poly C	144-151	peroxiredoxin 2, pseudogene 1	Mus musculus	57-61
3182859-1	1988	The asparagine-linked sugar chains of natural interferon-beta 1 secreted from human foreskin fibroblasts by poly I:poly C induction and of three recombinant human interferon-beta 1 produced by Chinese hamster ovary cells, mouse epithelial cells (C127), and human lung adenocarcinoma cells (PC8) were released quantitatively as oligosaccharides by hydrazinolysis followed by N-acetylation.	Poly C	115-121	interferon beta 1	Homo sapiens	46-63
2458149-5	1988	The kinetics of IL-1- and poly(rI).poly(rC)-induced CSA release were found to be different, in that poly(rI).poly(rC)-induced CSA production occurred more slowly.	Poly C	35-43	interleukin 1 alpha	Homo sapiens	16-20
2848929-4	1988	These results confirm earlier observations that IFN or polyinosinic.polycytidylic acid block the replication of HSV-1 in human, monkey and mouse cells no later than the immediate early phase of infection.	Poly C	68-86	interferon alpha 1	Homo sapiens	48-51
2458149-5	1988	The kinetics of IL-1- and poly(rI).poly(rC)-induced CSA release were found to be different, in that poly(rI).poly(rC)-induced CSA production occurred more slowly.	Poly C	109-117	interleukin 1 alpha	Homo sapiens	16-20
2458149-6	1988	Anti-IL-1 antiserum was able to completely neutralize the IL-1-induced CSA release, but had no effect on poly(rI).poly(rC)-induced CSF production, suggesting that the latter effect was mediated by other mechanisms than IL-1 in supernatant.	Poly C	114-122	colony stimulating factor 2	Homo sapiens	131-134
3262700-4	1988	To elucidate the mechanism of this inhibition, we examined the effect of IL1 on the synthesis of interferon-beta (IFN-beta), stimulated with polyinosinate.polycytidylate [poly(I).poly(C)].	Poly C	179-185	interferon beta 1	Homo sapiens	114-122
2458149-8	1988	Poly(rI).poly(rC) appeared to be a better inducer for M-CSF than IL-1.	Poly C	9-17	colony stimulating factor 1	Homo sapiens	54-59
3262700-6	1988	However, when IL1 was added simultaneously with poly(I).poly(C), or 2 h after poly(I).poly(C), IFN-beta synthesis was increased.	Poly C	56-63	interleukin 1 alpha	Homo sapiens	14-17
3226465-4	1988	The enzyme shows all the characteristics described for casein kinase II from other sources: it is independent of cyclic nucleotides, calcium/phospholipids, and double-stranded poly(I).poly(C); it can utilize both ATP and GTP as phosphoryl donors and can phosphorylate both casein and phosvitin but not histone.	Poly C	184-191	casein kinase 2 beta	Bos taurus	284-293
3262700-5	1988	When added 2 h or more before poly(I).poly(C), both forms of IL1 had a strong inhibitory effect on IFN-beta synthesis, as determined by antiviral assay of the IFN-beta protein or by quantitation of IFN-beta mRNA levels in Northern blot analysis.	Poly C	38-45	interleukin 1 alpha	Homo sapiens	61-64
3262700-6	1988	However, when IL1 was added simultaneously with poly(I).poly(C), or 2 h after poly(I).poly(C), IFN-beta synthesis was increased.	Poly C	56-62	interleukin 1 alpha	Homo sapiens	14-17
3262700-5	1988	When added 2 h or more before poly(I).poly(C), both forms of IL1 had a strong inhibitory effect on IFN-beta synthesis, as determined by antiviral assay of the IFN-beta protein or by quantitation of IFN-beta mRNA levels in Northern blot analysis.	Poly C	38-45	interferon beta 1	Homo sapiens	99-107
2837525-5	1988	Significant percentages (greater than 25%) of the LGL found in the liver and peritoneal cavity following viral infection or interferon induction with poly-inosinic:poly-cytidylic acid were defined morphologically as blasts (large cells with prominent nucleoli and intensely basophilic cytoplasms containing azurophilic granules).	Poly C	164-183	legless	Mus musculus	50-53
3262700-7	1988	The inhibitory action of IL1 on poly(I).poly(C)-induced IFN-beta synthesis was abolished in the presence of cycloheximide, suggesting that it is mediated indirectly by an IL1-induced product in the FS-4 cells.	Poly C	40-47	interleukin 1 alpha	Homo sapiens	25-28
3262700-7	1988	The inhibitory action of IL1 on poly(I).poly(C)-induced IFN-beta synthesis was abolished in the presence of cycloheximide, suggesting that it is mediated indirectly by an IL1-induced product in the FS-4 cells.	Poly C	40-47	interferon beta 1	Homo sapiens	56-64
3262700-7	1988	The inhibitory action of IL1 on poly(I).poly(C)-induced IFN-beta synthesis was abolished in the presence of cycloheximide, suggesting that it is mediated indirectly by an IL1-induced product in the FS-4 cells.	Poly C	40-47	interleukin 1 alpha	Homo sapiens	171-174
2453506-1	1988	Human fibroblasts were induced to secrete interferon (IFN) by treatment with the double-stranded RNA poly(inosinic).poly(cytidylic) acid or by infection with Newcastle disease virus.	Poly C	116-136	interferon alpha 1	Homo sapiens	54-57
3279118-9	1988	PCT-GF activity in supernatants of human FS-4 fibroblasts stimulated with TNF, IL-1 or poly(I).poly(C) was neutralized by antibody to rBSF-2, but not by antibodies neutralizing the antiviral activity of IFN-beta.	Poly C	95-102	tumor necrosis factor	Homo sapiens	74-77
3279118-9	1988	PCT-GF activity in supernatants of human FS-4 fibroblasts stimulated with TNF, IL-1 or poly(I).poly(C) was neutralized by antibody to rBSF-2, but not by antibodies neutralizing the antiviral activity of IFN-beta.	Poly C	95-102	interferon beta 1	Homo sapiens	203-211
2451028-9	1988	Poly(rC) and poly(dC) bind to rho competitively and with equal affinity and site size, although poly(rC) is the strongest cofactor for activating rho-dependent ATPase and poly(dC) has no ATPase cofactor activity at all.	Poly C	0-8	ATPase	Escherichia coli	160-166
2826599-13	1988	These results show that the observed conditioned enhancement of NK activity in conditioned animals is not caused by any nociceptive properties of the CS itself and is dependent on the IFN-beta produced after Poly I:C injection in the conditioned paradigm.	Poly C	208-216	interferon beta 1, fibroblast	Mus musculus	184-192
2449288-4	1987	Fibroblast cells grown on microcarriers in the presence of glucocorticoid hormones maintained their ability to produce interferon (IFN)-beta in a superinduction method with poly I: poly C and antimetabolites.	Poly C	181-187	interferon beta 1	Homo sapiens	119-140
3494192-5	1987	Exposure of cells to TNF enhanced IFN-beta 2 (but not IFN-beta 1) mRNA expression in response to poly(I).poly(C), an IFN inducer which is also known to stimulate FS-4 cell growth.	Poly C	105-112	tumor necrosis factor	Homo sapiens	21-24
3689426-8	1987	Compared to controls, cytochrome P-450 in both the lungs and livers of poly I:poly C treated rats declined by 40% at 24 hr and 55% at 48 hr (P less than 0.01).	Poly C	78-84	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	22-38
3689426-10	1987	In contrast, cytochrome b5 levels declined by less than 30% of control values during the first 48 hr following poly I:poly C injection (P less than 0.01) and returned to control levels by 72 hr.	Poly C	118-124	cytochrome b5 type A	Rattus norvegicus	13-26
2440179-8	1987	In the absence of virus infection, decreased levels of p68 kinase occur in cells following incubation with poly(I).poly(C).	Poly C	115-122	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	55-65
3805129-2	1987	Poly(I).poly(C) is a potent inducer of interferon (IFN)-beta in human fibroblasts.	Poly C	8-15	interferon beta 1	Homo sapiens	39-60
3545852-0	1987	Interleukin 1 and poly(rI).poly(rC) induce production of a hybridoma growth factor by human fibroblasts.	Poly C	27-35	interleukin 1 alpha	Homo sapiens	0-13
3545852-0	1987	Interleukin 1 and poly(rI).poly(rC) induce production of a hybridoma growth factor by human fibroblasts.	Poly C	27-35	interleukin 6	Homo sapiens	59-82
3805129-4	1987	Antiserum to interferon (IFN)-beta, added to poly(I).poly(C)-stimulated cultures in order to neutralize endogenously generated IFN, markedly amplified the mitogenic action.	Poly C	53-60	interferon beta 1	Homo sapiens	13-34
3805129-4	1987	Antiserum to interferon (IFN)-beta, added to poly(I).poly(C)-stimulated cultures in order to neutralize endogenously generated IFN, markedly amplified the mitogenic action.	Poly C	53-60	interferon alpha 1	Homo sapiens	25-28
3805129-7	1987	This effect of dexamethasone correlated with its marked inhibitory action on poly(I).poly(C)-stimulated IFN production.	Poly C	85-92	interferon alpha 1	Homo sapiens	104-107
3494192-5	1987	Exposure of cells to TNF enhanced IFN-beta 2 (but not IFN-beta 1) mRNA expression in response to poly(I).poly(C), an IFN inducer which is also known to stimulate FS-4 cell growth.	Poly C	105-112	interleukin 6	Homo sapiens	34-44
3494192-5	1987	Exposure of cells to TNF enhanced IFN-beta 2 (but not IFN-beta 1) mRNA expression in response to poly(I).poly(C), an IFN inducer which is also known to stimulate FS-4 cell growth.	Poly C	105-112	interferon alpha 1	Homo sapiens	34-37
3758081-1	1986	When human fibroblast cells were stimulated with poly(I) X poly(C) in the presence of cycloheximide for the production of interferon-beta (IFN-beta), a 26-kDa protein could be immunoprecipitated by antiserum raised against partially purified human IFN-beta [Content, J., De Wit, L., Pierard, D., Derynck, R., De Clercq, E. & Fiers, W. (1982) Proc.	Poly C	59-66	interferon beta 1	Homo sapiens	122-137
2430524-0	1986	Depression of cytochrome P-450 and alterations of protein metabolism in mice treated with the interferon inducer polyriboinosinic acid X polyribocytidylic acid.	Poly C	137-159	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	14-30
3758081-1	1986	When human fibroblast cells were stimulated with poly(I) X poly(C) in the presence of cycloheximide for the production of interferon-beta (IFN-beta), a 26-kDa protein could be immunoprecipitated by antiserum raised against partially purified human IFN-beta [Content, J., De Wit, L., Pierard, D., Derynck, R., De Clercq, E. & Fiers, W. (1982) Proc.	Poly C	59-66	interferon beta 1	Homo sapiens	139-147
3758081-1	1986	When human fibroblast cells were stimulated with poly(I) X poly(C) in the presence of cycloheximide for the production of interferon-beta (IFN-beta), a 26-kDa protein could be immunoprecipitated by antiserum raised against partially purified human IFN-beta [Content, J., De Wit, L., Pierard, D., Derynck, R., De Clercq, E. & Fiers, W. (1982) Proc.	Poly C	59-66	interferon beta 1	Homo sapiens	248-256
3745988-1	1986	The synthetic polyribonucleotide polyinosinate:polycytidylate [poly(I):poly(C)] was used to induce interferon (IFN) production in a rat leiomyosarcoma cell line.	Poly C	71-78	interferon alpha 1	Homo sapiens	111-114
2428755-9	1986	The excellent IFN inducer, poly I:C, at the tested dose range (0.03-3.0 mg/kg), displayed only a relatively weak adjuvant activity.	Poly C	27-35	interferon alpha 1	Homo sapiens	14-17
3081254-4	1986	In contrast, the lethal effect of the combination of IFN-gamma and poly(I).poly(C) was synergistic and this regimen produced a 40 to 80% reduction in colony formation.	Poly C	75-82	interferon gamma	Homo sapiens	53-62
3081254-6	1986	The concentration of the dsRNAs producing a 50% decrease in cell viability in combination with IFN-gamma (100 units/ml) was 6 micrograms/ml for poly(I).poly(C), 1 microgram/ml for poly(A).poly(U), 3 ng/ml for poly(ICLC), and 16 micrograms/ml for rIn.r(C13,U)n. DNA, RNA, and protein synthesis in IFN-gamma and poly(I).poly(C)-treated cells were reduced in a dose-dependent manner.	Poly C	152-159	interferon gamma	Homo sapiens	95-104
2428755-11	1986	This might be related to sufficient induction of IFN by low doses of poly I:C but not by DDA.	Poly C	69-77	interferon alpha 1	Homo sapiens	49-52
3921246-1	1985	The cytocidal activity of human immune interferon (IFN-gamma) in combination with the synthetic double-stranded RNA, poly(I).poly(C), was investigated in human colon carcinoma cell line HT-29.	Poly C	125-132	interferon gamma	Homo sapiens	32-60
2414376-2	1985	An IFN-alpha 1 cDNA insert containing such sequences can be used to isolate 15 IFN-beta 1 cDNA colonies present in a 2600-strong library in Escherichia coli prepared from polyadenylated RNA extracted from human diploid fibroblasts (FS-4) induced with poly(I).poly(C).	Poly C	259-265	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	83-89
3936614-4	1985	Partially thiolated polycytidylic acid (MPC) strongly inhibited only the DNA polymerase alpha of the "normal" cell line, whereas the corresponding enzymes of all three leukemic cell lines were relatively insensitive to MPC.	Poly C	20-38	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	73-93
3921246-2	1985	Three days of treatment with IFN-gamma (10 to 25 units/ml) resulted in 30 to 40% reduction in colony formation, whereas poly(I).poly(C) (25 to 100 micrograms/ml) reduced cell viability by 10 to 20% of control.	Poly C	128-135	interferon gamma	Homo sapiens	29-38
3921246-3	1985	The lethal effect of the combination of IFN-gamma and poly(I).poly(C) was synergistic wherein 70 to 90% reduction in colony formation was observed.	Poly C	62-69	interferon gamma	Homo sapiens	40-49
3921246-4	1985	Measurements of DNA, RNA, and protein synthesis after IFN-gamma and poly(I).poly(C) treatment showed a dose-dependent reduction in all three parameters.	Poly C	76-83	interferon gamma	Homo sapiens	54-63
3921246-5	1985	Recombinant IFN-gamma in combination with poly(I).poly(C) exhibited a similar effect.	Poly C	50-57	interferon gamma	Homo sapiens	12-21
3919027-7	1985	The 67-kDa protein kinase, uninducible by treatment with alpha, beta IFN (up to 13,000 units/ml), is instead induced upon treatment with gamma IFN at a similar rate of activity as in wild-type Friend leukemia cells, both when assayed in solution and after immobilization on poly(rI) X poly(rC)-agarose.	Poly C	285-294	interferon gamma	Mus musculus	143-146
6700582-3	1984	These cells were found to express high levels of human IFN-beta after polyriboinosinic acid-polyribocytidylic acid superinduction or NDV infection; this was a result of coamplification of the IFN-beta gene.	Poly C	92-114	interferon beta 1	Homo sapiens	55-63
6206680-2	1984	A CSF Poly(C)-avid ribonuclease (RNase) activity was determined in serum and CSF of 11 controls and 75 neurological patients (34 multiple sclerosis (MS), 18 infectious processes and 23 other neurological diseases (OND].	Poly C	6-13	colony stimulating factor 2	Homo sapiens	2-5
6206680-2	1984	A CSF Poly(C)-avid ribonuclease (RNase) activity was determined in serum and CSF of 11 controls and 75 neurological patients (34 multiple sclerosis (MS), 18 infectious processes and 23 other neurological diseases (OND].	Poly C	6-13	colony stimulating factor 2	Homo sapiens	77-80
6712732-3	1984	polyribocytidylic acid (poly IC) on the postnatal development of hepatic cytochrome P-450-linked monooxygenase systems of male rats from birth through early adolescence.	Poly C	0-22	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	73-89
6712732-3	1984	polyribocytidylic acid (poly IC) on the postnatal development of hepatic cytochrome P-450-linked monooxygenase systems of male rats from birth through early adolescence.	Poly C	24-31	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	73-89
2578572-4	1985	IFN was implicated as mediating the effect of poly(I)-poly(C) because high systemic levels of IFN were evident after injection, and neither the magnitude of the inflammatory response nor the T-cell levels were affected when poly(I)-poly(C)-treated mice were also given anti-IFN antiserum.	Poly C	54-61	interferon alpha 1	Homo sapiens	0-3
2578572-5	1985	However, the poly(I)-poly(C)-induced IFN did not seem to reduce the localized inflammatory response by affecting viral replication in brain tissue because the vaccinia virus titers present on days 6 through 8 of infection were similar to the titers in phosphate-buffered saline controls.	Poly C	21-28	interferon alpha 1	Homo sapiens	37-40
2985717-0	1985	Induction of human interferon gamma in nylon-column nonadherent human lymphocyte cells by heat-treated poly I:poly C.	Poly C	110-116	interferon gamma	Homo sapiens	19-35
2985717-3	1985	When nylon-column nonadherent cells (NNA cells) were induced by poly I:poly C which was prepared by heat-treatment, high levels of acid- and heat-labile interferon (IFN) were obtained.	Poly C	71-77	interferon alpha 1	Homo sapiens	141-169
6712731-3	1984	polyribocytidylic acid (poly IC), are known to depress hepatic cytochrome P-450-dependent monooxygenase systems and the induction of these systems by phenobarbital (PB) and 3-methylcholanthrene (MC) in mature male rats.	Poly C	0-22	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	63-79
6712731-3	1984	polyribocytidylic acid (poly IC), are known to depress hepatic cytochrome P-450-dependent monooxygenase systems and the induction of these systems by phenobarbital (PB) and 3-methylcholanthrene (MC) in mature male rats.	Poly C	24-31	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	63-79
6322211-0	1984	Depressant effects of the interferon inducer polyriboinosinic:polyribocytidylic acid on cytochrome P-450 hemoproteins.	Poly C	62-84	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	88-104
6306284-2	1983	The optimal conditions for induction of human IFN and of its mRNA in these transformants resembled those needed for mouse IFN: high concentrations of DEAE-dextran and low concentrations of polyriboinosinic acid-polyribocytidylic acid.	Poly C	211-233	interferon alpha 1	Homo sapiens	46-49
6191776-3	1983	The estrogen receptor was found to interact more strongly with poly(G), poly(U) than with poly(A), poly(C).	Poly C	99-105	estrogen receptor 1	Homo sapiens	4-21
6306284-2	1983	The optimal conditions for induction of human IFN and of its mRNA in these transformants resembled those needed for mouse IFN: high concentrations of DEAE-dextran and low concentrations of polyriboinosinic acid-polyribocytidylic acid.	Poly C	211-233	interferon alpha 1	Homo sapiens	122-125
6856471-1	1983	Northern blot analysis reveals that total RNA from human fibroblastoid cells (MG 63) induced with poly(I).poly(C) under conditions of IFN-beta production, contains predominantly a +/- 1,200 nucleotide long poly (A) mRNA (mRNA.M) which hybridizes with a Hu IFN-beta cDNA specific probe.	Poly C	106-112	interferon beta 1	Homo sapiens	134-142
6856471-1	1983	Northern blot analysis reveals that total RNA from human fibroblastoid cells (MG 63) induced with poly(I).poly(C) under conditions of IFN-beta production, contains predominantly a +/- 1,200 nucleotide long poly (A) mRNA (mRNA.M) which hybridizes with a Hu IFN-beta cDNA specific probe.	Poly C	106-112	interferon beta 1	Homo sapiens	256-264
6187846-1	1983	Systemic inoculation of the interferon (IFN) inducer polyinosinic-polycytidylic polyribonucleotide (poly I:poly C) into CBA/J mice produces a significant decrease in the number of thoracic duct lymphocytes (TDL) collected 6 to 22 hr after injection.	Poly C	107-113	interferon alpha 1	Homo sapiens	40-43
6187846-5	1983	2) Pretreatment of mice with sheep anti-murine IFN serum can block this effect of poly I:poly C.	Poly C	89-95	interferon alpha 1	Homo sapiens	47-50
6180119-2	1982	poly (C)-induced human diploid fibroblasts (FS-4) and from several similarly induced human-mouse somatic cell hybrids by electrophoresis through agarose-CH3HgOH tube gels led to the detection of at least five translationally active human IFN-beta mRNA species.	Poly C	0-8	interferon beta 1	Homo sapiens	238-246
6838554-0	1983	Induction of human leukocyte interferon by heat-treated poly I: poly C.	Poly C	64-70	interferon alpha 1	Homo sapiens	29-39
6838554-1	1983	Synthetic double stranded RNA (poly I: poly C) was prepared from polyinosinic acid (poly I) and polycytidylic acid (poly C) by heat-treated followed by gradual cooling, and was used for induction of human leukocyte interferon (IFN).	Poly C	39-45	interferon alpha 1	Homo sapiens	205-231
6838554-1	1983	Synthetic double stranded RNA (poly I: poly C) was prepared from polyinosinic acid (poly I) and polycytidylic acid (poly C) by heat-treated followed by gradual cooling, and was used for induction of human leukocyte interferon (IFN).	Poly C	96-114	interferon alpha 1	Homo sapiens	205-231
6838554-2	1983	When poly I: poly C solution was heated at 37 - 65 degrees C for 30 minutes, high activity of human IFN (10,000 - 60,000 i. u./ml) was obtained.	Poly C	13-19	interferon alpha 1	Homo sapiens	100-103
6838554-3	1983	In this system, the optimum molecular weight of poly I: poly C to induce IFN was 12.6 - 17.6 S. The properties of induced IFN were heat- and acid- stable, and it was neutralized with anti-IFN alpha serum.	Poly C	56-62	interferon alpha 1	Homo sapiens	73-76
6838554-3	1983	In this system, the optimum molecular weight of poly I: poly C to induce IFN was 12.6 - 17.6 S. The properties of induced IFN were heat- and acid- stable, and it was neutralized with anti-IFN alpha serum.	Poly C	56-62	interferon alpha 1	Homo sapiens	122-125
6838554-3	1983	In this system, the optimum molecular weight of poly I: poly C to induce IFN was 12.6 - 17.6 S. The properties of induced IFN were heat- and acid- stable, and it was neutralized with anti-IFN alpha serum.	Poly C	56-62	interferon alpha 1	Homo sapiens	188-197
6750198-4	1982	poly C or LPS released a macrophage cytotoxin (MCT) that rapidly bound to syngeneic (EL 4) or allogeneic (NS-1, YAC-1) tumor cells but did not bind to normal splenocytes.	Poly C	0-6	ADP-ribosyltransferase 1	Mus musculus	112-117
6956764-14	1982	poly C-stimulated PEMM caused 31--56% lysis of syngeneic EL-4 and allogeneic L-929, NS-1, and YAC-1 tumor cells in vitro but was not cytotoxic for normal cells.	Poly C	0-6	epilepsy 4	Mus musculus	57-82
6956764-14	1982	poly C-stimulated PEMM caused 31--56% lysis of syngeneic EL-4 and allogeneic L-929, NS-1, and YAC-1 tumor cells in vitro but was not cytotoxic for normal cells.	Poly C	0-6	ADP-ribosyltransferase 1	Mus musculus	94-99
6180744-0	1982	Sequential administrations of polyriboinosinic acid and polyribocytidylic acid induce interferon and depress the hepatic cytochrome P-450-dependent monooxygenase system.	Poly C	56-78	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	121-137
6452899-5	1981	The purified rho has an ATPase specific activity of 32 nmol of Pi released min-1 microgram-1 when poly(cytidylic acid) is used as a cofactor, and it functions effectively in termination of T7 DNA transcription.	Poly C	98-118	ATPase	Escherichia coli	24-30
6178587-7	1982	poly(C) competes poorly for the androgen receptor.	Poly C	0-7	androgen receptor	Mus musculus	32-49
687577-8	1978	At saturation of poly(I).poly(C) by Fab fragments, the number of binding sites of ethidium bromide is only reduced by a factor of two.	Poly C	25-32	FA complementation group B	Homo sapiens	36-39
6165879-7	1981	The presence of polyC during preincubation protected rho+ activity but produced substantial inactivation of rho-115 ATPase.	Poly C	16-21	ATPase	Escherichia coli	116-122
6165879-9	1981	Concentrations of polyC between 625 ng/ml and 100 micrograms/ml yielded the same extent of rho-115 ATPase inactivation during preincubation at 45 degrees C. Thermal inactivation of rho-115 ATPase by polyC was halted by shifting preincubation temperature from 45 degrees C to 35 degrees C, indicating that polyC-induced destabilization of rho-115 was irreversible.	Poly C	18-23	ATPase	Escherichia coli	99-105
6165879-9	1981	Concentrations of polyC between 625 ng/ml and 100 micrograms/ml yielded the same extent of rho-115 ATPase inactivation during preincubation at 45 degrees C. Thermal inactivation of rho-115 ATPase by polyC was halted by shifting preincubation temperature from 45 degrees C to 35 degrees C, indicating that polyC-induced destabilization of rho-115 was irreversible.	Poly C	18-23	ATPase	Escherichia coli	189-195
6165879-9	1981	Concentrations of polyC between 625 ng/ml and 100 micrograms/ml yielded the same extent of rho-115 ATPase inactivation during preincubation at 45 degrees C. Thermal inactivation of rho-115 ATPase by polyC was halted by shifting preincubation temperature from 45 degrees C to 35 degrees C, indicating that polyC-induced destabilization of rho-115 was irreversible.	Poly C	199-204	ATPase	Escherichia coli	189-195
570180-2	1978	The stimulatory effect on interferon production was not expressed in polyriboinosinic acid:polycytidylic acid-induced interferon.	Poly C	91-109	interferon	Gallus gallus	118-128
289438-4	1979	Simultaneous treatment of MI cells with the anti-interferon serum and copolymer of polyinosine and polycytidylic acids and D-factor abolished the enhancing effect of copolymer of polyinosine and polycytidylic acids on the action of the D-factor.	Poly C	99-118	leukemia inhibitory factor	Mus musculus	236-244
289438-4	1979	Simultaneous treatment of MI cells with the anti-interferon serum and copolymer of polyinosine and polycytidylic acids and D-factor abolished the enhancing effect of copolymer of polyinosine and polycytidylic acids on the action of the D-factor.	Poly C	195-214	leukemia inhibitory factor	Mus musculus	123-131
289438-4	1979	Simultaneous treatment of MI cells with the anti-interferon serum and copolymer of polyinosine and polycytidylic acids and D-factor abolished the enhancing effect of copolymer of polyinosine and polycytidylic acids on the action of the D-factor.	Poly C	195-214	leukemia inhibitory factor	Mus musculus	236-244
687577-6	1978	The complexes between poly(I).poly(C) and Fab fragments interact with ethidium bromide.	Poly C	30-36	FA complementation group B	Homo sapiens	42-45
940771-2	1976	poly C, have been determined by potentiometric titration as a function of either ionic strength (Na+) or Mg2+ concentration.	Poly C	0-6	mucin 7, secreted	Homo sapiens	105-108
640718-3	1978	Thus, the effect of methylated bovine serum albumin on the antibody production to poly(ADP-ribose) resembled the case of poly(I).poly(C) and was different from the case of single stranded DNA.	Poly C	129-136	albumin	Mus musculus	38-51
188983-8	1977	There were about 170 nucleotides in the poly (C) tract of the SAT1-7 RNA compared with around 100 in the SAT1-82 RNA.	Poly C	40-48	diamine acetyltransferase 1	Mesocricetus auratus	62-68
188983-8	1977	There were about 170 nucleotides in the poly (C) tract of the SAT1-7 RNA compared with around 100 in the SAT1-82 RNA.	Poly C	40-48	diamine acetyltransferase 1	Mesocricetus auratus	62-66
49986-3	1975	Partially thiolated polycytidylic acids (MPC I-III, containing 1.7%, 3.5%, and 8.6% 5-mercaptocytidylate units, respectively) inhibited the DNA-polymerase of Friend leukemia virus (FVL) in the endogenic reaction as well as in the presence of poly rA-(dT)14 or poly (dA-dT) templates; the inhibitory activities were directly related to the percent of tholation.	Poly C	20-39	coagulation factor V	Homo sapiens	181-184
1259951-6	1976	Using thermodynanic parameters obtained from circular dichroism (CD) and uv absorbance melting curves, the following rate constants k (at 20 degrees C, 1.05 M ionic strength, pH 7) and activation enthalpies EA were calculated for poly (C): helix formation kR = 1.11 X 10(-7) s-1 (EAR = 2.6 kcal); helix dissociation kD = 2.1 X 10(6) s-1 (EAD = 11.9 kcal).	Poly C	230-237	nuclear receptor subfamily 2 group F member 6	Homo sapiens	280-287
764866-1	1976	Phage Qbeta RNA replicase consists of four nonidentical subunits three of which are required for poly(C)-directed synthesis of poly(G): a phage-coded polypeptide and the two host-supplied protein biosynthesis elongation factors EF-Tu and EF-Ts.	Poly C	97-104	Tu translation elongation factor, mitochondrial	Homo sapiens	228-233
764866-1	1976	Phage Qbeta RNA replicase consists of four nonidentical subunits three of which are required for poly(C)-directed synthesis of poly(G): a phage-coded polypeptide and the two host-supplied protein biosynthesis elongation factors EF-Tu and EF-Ts.	Poly C	97-104	Ts translation elongation factor, mitochondrial	Homo sapiens	238-243
1112795-8	1975	It also cleaved other substrates of RNase A such as 5"-(3"-cytidylyl)-guanosine, 5"-(3"-uridylyl)-guanosine, and polycytidylic acid.	Poly C	113-131	ribonuclease A family member 1, pancreatic	Homo sapiens	36-43
34039638-6	2021	Mkp-1 -/- bone marrow-derived macrophages (BMDM) produced higher levels of IFN-beta mRNA and protein than did wild-type BMDM upon treatment with LPS, E. coli, polyinosinic:polycytidylic acid, and herring sperm DNA.	Poly C	172-190	dual specificity phosphatase 1	Mus musculus	0-5
34028652-7	2021	Polyinosinic: polycytidylic acid (poly [I:C])-stimulated macrophage cells and 10-7 M 1,25 OH-vitamin D3 significantly decreased gene expression of ICAM1, TLR3, IL6, IL8, and TNFalpha (P < 0.0001).	Poly C	14-32	intercellular adhesion molecule 1	Mus musculus	147-152
34028652-7	2021	Polyinosinic: polycytidylic acid (poly [I:C])-stimulated macrophage cells and 10-7 M 1,25 OH-vitamin D3 significantly decreased gene expression of ICAM1, TLR3, IL6, IL8, and TNFalpha (P < 0.0001).	Poly C	14-32	toll-like receptor 3	Mus musculus	154-158
33827951-9	2021	We further uncovered that knockout of FUS abolishes the ability to form SGs upon CVB3 infection or polyinosinic:polycytidylic acid (polyIC) treatment.	Poly C	112-130	FUS RNA binding protein	Homo sapiens	38-41
34028652-7	2021	Polyinosinic: polycytidylic acid (poly [I:C])-stimulated macrophage cells and 10-7 M 1,25 OH-vitamin D3 significantly decreased gene expression of ICAM1, TLR3, IL6, IL8, and TNFalpha (P < 0.0001).	Poly C	14-32	interleukin 6	Mus musculus	160-163
34028652-7	2021	Polyinosinic: polycytidylic acid (poly [I:C])-stimulated macrophage cells and 10-7 M 1,25 OH-vitamin D3 significantly decreased gene expression of ICAM1, TLR3, IL6, IL8, and TNFalpha (P < 0.0001).	Poly C	14-32	chemokine (C-X-C motif) ligand 15	Mus musculus	165-168
33046534-3	2021	Here, we show that immunotherapy with a ligand of Toll-like receptor-3 (TLR3), polyinosinic:polycytidylic acid (pIC), restores the deficient response to chemotherapy of tumors lacking ANXA1 developing in immunocompetent mice or that of normal cancers growing in FPR1-deficient mice.	Poly C	92-110	toll-like receptor 3	Mus musculus	50-70
34028652-7	2021	Polyinosinic: polycytidylic acid (poly [I:C])-stimulated macrophage cells and 10-7 M 1,25 OH-vitamin D3 significantly decreased gene expression of ICAM1, TLR3, IL6, IL8, and TNFalpha (P < 0.0001).	Poly C	14-32	tumor necrosis factor	Mus musculus	174-182
33557113-3	2021	Therefore, in the present study, we examined the effect of MIA induced by polyinosinic:polycytidylic acid (Poly I:C) on the CX3CL1-CX3CR1 and CD200-CD200R axes, microglial trajectory (MhcII, Cd40, iNos, Il-1beta, Tnf-alpha, Il-6, Arg1, Igf-1, Tgf-beta and Il-4), and schizophrenia-like behaviour in adult male offspring of Sprague-Dawley rats.	Poly C	87-105	C-X3-C motif chemokine ligand 1	Rattus norvegicus	124-130
33557113-3	2021	Therefore, in the present study, we examined the effect of MIA induced by polyinosinic:polycytidylic acid (Poly I:C) on the CX3CL1-CX3CR1 and CD200-CD200R axes, microglial trajectory (MhcII, Cd40, iNos, Il-1beta, Tnf-alpha, Il-6, Arg1, Igf-1, Tgf-beta and Il-4), and schizophrenia-like behaviour in adult male offspring of Sprague-Dawley rats.	Poly C	87-105	Cd200 molecule	Rattus norvegicus	142-147
33684425-4	2021	In Experiment 2, rats were neonatally treated with saline or the immune system stimulant polyinosinic:polycytidylic acid (Poly I:C) from P5-7.	Poly C	102-120	cyclin-dependent kinase inhibitor 1C	Rattus norvegicus	137-141
33921475-5	2021	We found that co-culture of iDCs with differentially activated LAD2 MCs in serum-containing media significantly modulated polyinosinic:polycytidylic acid (poly I:C)-elicited DC maturation as determined through the surface expression of the maturation markers CD80, CD83, CD86, and human leukocyte antigen(HLA)-DR. Once iDCs were generated in serum-free conditions, they became refractory to the maturation with poly I:C, and the LAD2 MC modulatory potential was minimized.	Poly C	135-153	CD80 molecule	Homo sapiens	259-263
33921475-5	2021	We found that co-culture of iDCs with differentially activated LAD2 MCs in serum-containing media significantly modulated polyinosinic:polycytidylic acid (poly I:C)-elicited DC maturation as determined through the surface expression of the maturation markers CD80, CD83, CD86, and human leukocyte antigen(HLA)-DR. Once iDCs were generated in serum-free conditions, they became refractory to the maturation with poly I:C, and the LAD2 MC modulatory potential was minimized.	Poly C	135-153	CD83 molecule	Homo sapiens	265-269
33921475-5	2021	We found that co-culture of iDCs with differentially activated LAD2 MCs in serum-containing media significantly modulated polyinosinic:polycytidylic acid (poly I:C)-elicited DC maturation as determined through the surface expression of the maturation markers CD80, CD83, CD86, and human leukocyte antigen(HLA)-DR. Once iDCs were generated in serum-free conditions, they became refractory to the maturation with poly I:C, and the LAD2 MC modulatory potential was minimized.	Poly C	135-153	CD86 molecule	Homo sapiens	271-275
33724572-3	2021	Here, we demonstrate that transcription of RORgamma is activated by heterogeneous nuclear ribonucleoprotein K (hnRNP K) via the poly(C) motif within its proximal promoter.	Poly C	128-135	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	68-109
33724572-3	2021	Here, we demonstrate that transcription of RORgamma is activated by heterogeneous nuclear ribonucleoprotein K (hnRNP K) via the poly(C) motif within its proximal promoter.	Poly C	128-135	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	111-118
33046534-3	2021	Here, we show that immunotherapy with a ligand of Toll-like receptor-3 (TLR3), polyinosinic:polycytidylic acid (pIC), restores the deficient response to chemotherapy of tumors lacking ANXA1 developing in immunocompetent mice or that of normal cancers growing in FPR1-deficient mice.	Poly C	92-110	toll-like receptor 3	Mus musculus	72-76
33046534-3	2021	Here, we show that immunotherapy with a ligand of Toll-like receptor-3 (TLR3), polyinosinic:polycytidylic acid (pIC), restores the deficient response to chemotherapy of tumors lacking ANXA1 developing in immunocompetent mice or that of normal cancers growing in FPR1-deficient mice.	Poly C	92-110	annexin A1	Mus musculus	184-189
33046534-3	2021	Here, we show that immunotherapy with a ligand of Toll-like receptor-3 (TLR3), polyinosinic:polycytidylic acid (pIC), restores the deficient response to chemotherapy of tumors lacking ANXA1 developing in immunocompetent mice or that of normal cancers growing in FPR1-deficient mice.	Poly C	92-110	formyl peptide receptor 1	Mus musculus	262-266
33087502-8	2020	Furthermore, HSA also inhibited polyinosinic:polycytidylic acid- and lipopolysaccharide-induced interferon regulatory factor 3 phosphorylation and TIR domain-containing adapter-inducing interferon-beta-mediated responses, which are exclusive of endosomal TLR3 and TLR4 signaling, respectively.	Poly C	45-63	interferon regulatory factor 3	Homo sapiens	96-126
33452755-4	2021	Here, we found that simvastatin decreased polyinosinic-polycytidylic acid [poly(I:C)]-induced expression of antiviral interferon (IFN)-beta and IFN-stimulated genes (ISGs) in the bronchoalveolar lavage fluid (BALF) and lungs of mice with high-fat diet-induced hyperlipidemia.	Poly C	54-73	interferon alpha	Mus musculus	118-139
33387195-5	2021	RFLS was stimulated with Toll-like receptor 3 (TLR3) ligand polyinosinic:polycytidylic acid (poly I:C), a synthetic double-stranded RNA mimetic.	Poly C	73-91	toll like receptor 3	Homo sapiens	25-45
33387195-5	2021	RFLS was stimulated with Toll-like receptor 3 (TLR3) ligand polyinosinic:polycytidylic acid (poly I:C), a synthetic double-stranded RNA mimetic.	Poly C	73-91	toll like receptor 3	Homo sapiens	47-51
33154038-7	2020	In MRL/Mp and IL-10-/- mice, AIP is induced by repeated polyinosinic:polycytidylic acid injection.	Poly C	69-87	interleukin 10	Mus musculus	14-19
32979613-7	2020	The sandwich ELISA effectively detected an increased IFN-alpha production in chicken macrophage cells stimulated by polyinosinic:polycytidylic acid (poly I:C), and its minimum detectable level was about 25 pg/mL.	Poly C	129-147	interferon	Gallus gallus	53-62
33035644-6	2020	Expression of IFIT5 was significantly up-regulated following Newcastle disease virus (NDV)-, polyinosinic:polycytidylic acid [poly (I:C)]-, and poly(deoxyadenylic-thymidylic)[poly (dA:dT)]-triggered antiviral immune response.	Poly C	106-124	interferon induced protein with tetratricopeptide repeats 5	Homo sapiens	14-19
33087502-8	2020	Furthermore, HSA also inhibited polyinosinic:polycytidylic acid- and lipopolysaccharide-induced interferon regulatory factor 3 phosphorylation and TIR domain-containing adapter-inducing interferon-beta-mediated responses, which are exclusive of endosomal TLR3 and TLR4 signaling, respectively.	Poly C	45-63	toll like receptor 3	Homo sapiens	255-259
33087502-8	2020	Furthermore, HSA also inhibited polyinosinic:polycytidylic acid- and lipopolysaccharide-induced interferon regulatory factor 3 phosphorylation and TIR domain-containing adapter-inducing interferon-beta-mediated responses, which are exclusive of endosomal TLR3 and TLR4 signaling, respectively.	Poly C	45-63	toll like receptor 4	Homo sapiens	264-268
32492632-7	2020	Pretreatment with IFNgamma robustly enhanced anti-viral gene expression induced by the viral mimetic polyinosinic: polycytidylic acid (PIC), and this potentiating effect of IFNgamma was markedly attenuated by inhibitors of DNL.	Poly C	115-133	interferon gamma	Rattus norvegicus	18-26
33086712-4	2020	We demonstrated that polyinosinic:polycytidylic acid (poly (I:C)) stimulation and viral infection (vesicular stomatitis (VSV) or porcine reproductive and respiratory syndrome virus (PRRSV)) induce expression of porTRIM26, whereas knock-down expression of porTRIM26 promotes interferon (IFN)- production after poly (I:C) stimulation and virus infection (VSV or PRRSV).	Poly C	34-52	interferon alpha 1	Homo sapiens	274-290
32923700-7	2020	We showed stimulation of polyinosinic:polycytidylic acid (poly I:C), which led BEAS-2B to produce interferon (IFN)-beta.	Poly C	38-56	IFN1@	Homo sapiens	98-119
32492632-7	2020	Pretreatment with IFNgamma robustly enhanced anti-viral gene expression induced by the viral mimetic polyinosinic: polycytidylic acid (PIC), and this potentiating effect of IFNgamma was markedly attenuated by inhibitors of DNL.	Poly C	115-133	interferon gamma	Rattus norvegicus	173-181
32492632-7	2020	Pretreatment with IFNgamma robustly enhanced anti-viral gene expression induced by the viral mimetic polyinosinic: polycytidylic acid (PIC), and this potentiating effect of IFNgamma was markedly attenuated by inhibitors of DNL.	Poly C	135-138	interferon gamma	Rattus norvegicus	18-26
32492632-7	2020	Pretreatment with IFNgamma robustly enhanced anti-viral gene expression induced by the viral mimetic polyinosinic: polycytidylic acid (PIC), and this potentiating effect of IFNgamma was markedly attenuated by inhibitors of DNL.	Poly C	135-138	interferon gamma	Rattus norvegicus	173-181
32829711-0	2020	The prenatal challenge with lipopolysaccharide and polyinosinic:polycytidylic acid disrupts CX3CL1-CX3CR1 and CD200-CD200R signalling in the brains of male rat offspring: a link to schizophrenia-like behaviours.	Poly C	64-82	C-X3-C motif chemokine ligand 1	Rattus norvegicus	92-98
32829711-0	2020	The prenatal challenge with lipopolysaccharide and polyinosinic:polycytidylic acid disrupts CX3CL1-CX3CR1 and CD200-CD200R signalling in the brains of male rat offspring: a link to schizophrenia-like behaviours.	Poly C	64-82	C-X3-C motif chemokine receptor 1	Rattus norvegicus	99-105
32829711-0	2020	The prenatal challenge with lipopolysaccharide and polyinosinic:polycytidylic acid disrupts CX3CL1-CX3CR1 and CD200-CD200R signalling in the brains of male rat offspring: a link to schizophrenia-like behaviours.	Poly C	64-82	Cd200 molecule	Rattus norvegicus	110-115
32824595-3	2020	Of the various TLR ligands examined, the TLR3-specific ligand polyinosinic:polycytidylic acid (poly I:C), significantly induced TNF production and the upregulation of other TLR transcripts, in particular, TLR2.	Poly C	75-93	toll-like receptor 2	Mus musculus	15-18
32824595-3	2020	Of the various TLR ligands examined, the TLR3-specific ligand polyinosinic:polycytidylic acid (poly I:C), significantly induced TNF production and the upregulation of other TLR transcripts, in particular, TLR2.	Poly C	75-93	toll-like receptor 3	Mus musculus	41-45
32824595-3	2020	Of the various TLR ligands examined, the TLR3-specific ligand polyinosinic:polycytidylic acid (poly I:C), significantly induced TNF production and the upregulation of other TLR transcripts, in particular, TLR2.	Poly C	75-93	tumor necrosis factor	Mus musculus	128-131
32824595-3	2020	Of the various TLR ligands examined, the TLR3-specific ligand polyinosinic:polycytidylic acid (poly I:C), significantly induced TNF production and the upregulation of other TLR transcripts, in particular, TLR2.	Poly C	75-93	toll-like receptor 2	Mus musculus	41-44
32824595-3	2020	Of the various TLR ligands examined, the TLR3-specific ligand polyinosinic:polycytidylic acid (poly I:C), significantly induced TNF production and the upregulation of other TLR transcripts, in particular, TLR2.	Poly C	75-93	toll-like receptor 2	Mus musculus	205-209
32583610-4	2020	In normal human keratinocytes in vitro, TSLP was induced by polyinosinic:polycytidylic acid (Poly:IC), tumor necrosis factor (TNF)-alpha, and interleukin (IL)-4 and then quantified by ELISA in supernatants.	Poly C	73-91	thymic stromal lymphopoietin	Homo sapiens	40-44
32768236-7	2020	Host cell poly(C) binding protein 2 (PCBP2) was determined to bind and interact with PLP1.	Poly C	10-17	poly(rC) binding protein 2	Homo sapiens	37-42
32454326-10	2020	We functionally challenged ovaries in vitro, by polyinosinic:polycytidylic acid (poly I:C) and LPS, known to activate TLR3 and TLR4, respectively, and found a tendency for increased IL-6 production, which was particular evident in the LPS-treated group.	Poly C	61-79	toll like receptor 3	Homo sapiens	118-122
32454326-10	2020	We functionally challenged ovaries in vitro, by polyinosinic:polycytidylic acid (poly I:C) and LPS, known to activate TLR3 and TLR4, respectively, and found a tendency for increased IL-6 production, which was particular evident in the LPS-treated group.	Poly C	61-79	toll like receptor 4	Homo sapiens	127-131
32454326-10	2020	We functionally challenged ovaries in vitro, by polyinosinic:polycytidylic acid (poly I:C) and LPS, known to activate TLR3 and TLR4, respectively, and found a tendency for increased IL-6 production, which was particular evident in the LPS-treated group.	Poly C	61-79	interleukin 6	Homo sapiens	182-186
32768236-7	2020	Host cell poly(C) binding protein 2 (PCBP2) was determined to bind and interact with PLP1.	Poly C	10-17	proteolipid protein 1	Homo sapiens	85-89
32455939-0	2020	Polyinosinic: Polycytidylic Acid and Murine Cytomegalovirus Modulate Expression of Murine IL-10 and IL-21 in White Adipose Tissue.	Poly C	14-32	interleukin 10	Mus musculus	90-95
32641167-3	2020	Polyinosinic:polycytidylic acid (pIC) mimics viral infections through binding to pattern recognition receptors (e.g. TLR-3).	Poly C	13-31	toll-like receptor 3	Mus musculus	117-122
32504419-3	2020	By using a previously established mouse model of depression induced by combined delivery of IFN-alpha and polyinosinic:polycytidylic acid (poly(I:C)), a TLR3 agonist, we provide evidence that IFN-alpha and poly(I:C) reduce apical dendritic spine density in the hippocampal CA1 area ex vivo via mechanisms involving decreased TrkB signaling.	Poly C	119-137	toll-like receptor 3	Mus musculus	153-157
32504419-3	2020	By using a previously established mouse model of depression induced by combined delivery of IFN-alpha and polyinosinic:polycytidylic acid (poly(I:C)), a TLR3 agonist, we provide evidence that IFN-alpha and poly(I:C) reduce apical dendritic spine density in the hippocampal CA1 area ex vivo via mechanisms involving decreased TrkB signaling.	Poly C	119-137	interferon alpha	Mus musculus	192-201
32504419-3	2020	By using a previously established mouse model of depression induced by combined delivery of IFN-alpha and polyinosinic:polycytidylic acid (poly(I:C)), a TLR3 agonist, we provide evidence that IFN-alpha and poly(I:C) reduce apical dendritic spine density in the hippocampal CA1 area ex vivo via mechanisms involving decreased TrkB signaling.	Poly C	119-137	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	325-329
32455939-0	2020	Polyinosinic: Polycytidylic Acid and Murine Cytomegalovirus Modulate Expression of Murine IL-10 and IL-21 in White Adipose Tissue.	Poly C	14-32	interleukin 21	Mus musculus	100-105
32455939-3	2020	We investigated whether viral stimuli, polyinosinic: polycytidylic acid (poly(I:C)) or whole replicative murine cytomegalovirus (MCMV), could stimulate the expression of IL-10 in murine WAT using in vivo and ex vivo approaches.	Poly C	53-71	interleukin 10	Homo sapiens	170-175
32273347-6	2020	RESULTS: In vitro-generated CD103+ cDC1s produced cDC1-associated factors such as interleukin-12p70 and CXCL10, and demonstrated antigen cross-presentation activity on stimulation with the toll-like receptor 3 agonist polyinosinic:polycytidylic acid (poly I:C).	Poly C	231-249	integrin alpha E, epithelial-associated	Mus musculus	28-33
32568266-1	2020	Polyinosinic:polycytidylic acid (poly[I:C]) can stimulate Toll-like receptor 3 (TLR3) signaling pathways.	Poly C	13-31	toll like receptor 3	Gallus gallus	58-78
32568266-1	2020	Polyinosinic:polycytidylic acid (poly[I:C]) can stimulate Toll-like receptor 3 (TLR3) signaling pathways.	Poly C	13-31	toll like receptor 3	Gallus gallus	80-84
32273347-6	2020	RESULTS: In vitro-generated CD103+ cDC1s produced cDC1-associated factors such as interleukin-12p70 and CXCL10, and demonstrated antigen cross-presentation activity on stimulation with the toll-like receptor 3 agonist polyinosinic:polycytidylic acid (poly I:C).	Poly C	231-249	toll-like receptor 3	Mus musculus	189-209
31907279-3	2020	Here, we demonstrate that heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a key regulator that activates Dbp transcription via the poly(C) motif within its proximal promoter.	Poly C	138-145	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	26-67
32034064-6	2020	Treatment of BAFF-RFP mice with polyinosinic:polycytidylic acid increased BAFF expression in splenic Ly6Chi inflammatory MOs, CD11bhi activated NK subset, and in bone marrow myeloid precursors.	Poly C	45-63	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	13-17
31907279-3	2020	Here, we demonstrate that heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a key regulator that activates Dbp transcription via the poly(C) motif within its proximal promoter.	Poly C	138-145	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	69-76
31907279-3	2020	Here, we demonstrate that heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a key regulator that activates Dbp transcription via the poly(C) motif within its proximal promoter.	Poly C	138-145	D-box binding PAR bZIP transcription factor	Homo sapiens	112-115
31907279-4	2020	Biochemical analyses identified hnRNP K as a specific protein that directly associates with the poly(C) motif in vitro Interestingly, we further confirmed the rhythmic binding of endogenous hnRNP K within the Dbp promoter through chromatin immunoprecipitation as well as the cycling expression of hnRNP K.	Poly C	96-103	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	32-39
31907279-4	2020	Biochemical analyses identified hnRNP K as a specific protein that directly associates with the poly(C) motif in vitro Interestingly, we further confirmed the rhythmic binding of endogenous hnRNP K within the Dbp promoter through chromatin immunoprecipitation as well as the cycling expression of hnRNP K.	Poly C	96-103	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	190-197
31907279-4	2020	Biochemical analyses identified hnRNP K as a specific protein that directly associates with the poly(C) motif in vitro Interestingly, we further confirmed the rhythmic binding of endogenous hnRNP K within the Dbp promoter through chromatin immunoprecipitation as well as the cycling expression of hnRNP K.	Poly C	96-103	D-box binding PAR bZIP transcription factor	Homo sapiens	209-212
31907279-4	2020	Biochemical analyses identified hnRNP K as a specific protein that directly associates with the poly(C) motif in vitro Interestingly, we further confirmed the rhythmic binding of endogenous hnRNP K within the Dbp promoter through chromatin immunoprecipitation as well as the cycling expression of hnRNP K.	Poly C	96-103	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	190-197
30997942-5	2019	In this study, polyinosinic polycytidylic acid (polyI:C) was used as an activator of TLR3.	Poly C	48-55	toll-like receptor 3	Mus musculus	85-89
31817146-3	2019	In this study, ginsenoside Rh2 was shown to exert the most effective anti-inflammatory action on thymic stromal lymphopoietin (TSLP) and interleukin 8 in tumor necrosis factor-alpha and polyinosinic: polycytidylic acid induced normal human keratinocytes by inhibiting proinflammatory cytokines at both protein and transcriptional levels.	Poly C	200-218	Rh associated glycoprotein	Homo sapiens	27-30
31809875-0	2020	Repeat exposure to polyinosinic:polycytidylic acid induces TLR3 expression via JAK-STAT signaling and synergistically potentiates NFkappaB-RelA signaling in ARPE-19 cells.	Poly C	32-50	toll like receptor 3	Homo sapiens	59-63
31809875-0	2020	Repeat exposure to polyinosinic:polycytidylic acid induces TLR3 expression via JAK-STAT signaling and synergistically potentiates NFkappaB-RelA signaling in ARPE-19 cells.	Poly C	32-50	nuclear factor kappa B subunit 1	Homo sapiens	130-138
31809875-0	2020	Repeat exposure to polyinosinic:polycytidylic acid induces TLR3 expression via JAK-STAT signaling and synergistically potentiates NFkappaB-RelA signaling in ARPE-19 cells.	Poly C	32-50	RELA proto-oncogene, NF-kB subunit	Homo sapiens	139-143
31809875-6	2020	We used the human RPE-derived cell line ARPE-19 as a model system for RPE signaling and measured NFkappaB expression and activity in response to TLR3 stimulation with its ligand, polyinosinic:polycytidylic acid (pI:C).	Poly C	192-210	nuclear factor kappa B subunit 1	Homo sapiens	97-105
31809875-6	2020	We used the human RPE-derived cell line ARPE-19 as a model system for RPE signaling and measured NFkappaB expression and activity in response to TLR3 stimulation with its ligand, polyinosinic:polycytidylic acid (pI:C).	Poly C	192-210	toll like receptor 3	Homo sapiens	145-149
31796819-4	2019	Compared to wild-type, Scga1b1-Foxo3a-/- mice show reduced IFN-alpha, IFN-beta, IFN-lambda2/3 in response to challenge with RV or double-stranded (ds)RNA mimic, Poly Inosinic-polycytidylic acid (Poly I:C) indicating defective dsRNA receptor signaling.	Poly C	161-193	forkhead box O3	Mus musculus	31-37
30997942-8	2019	We observed that exposure to polyI:C induced IFN-gamma+ Foxp3+ iTregs in mouse intestine and in the culture.	Poly C	29-36	interferon gamma	Mus musculus	45-54
30997942-8	2019	We observed that exposure to polyI:C induced IFN-gamma+ Foxp3+ iTregs in mouse intestine and in the culture.	Poly C	29-36	forkhead box P3	Mus musculus	56-61
31384667-5	2019	Further expansion of tumor-resident CD103+ DCs by injecting the FMS-related tyrosine kinase 3 ligand, the formative cytokine for CD103+ DCs, provided a platform for a booster immunization with the Wilms tumor antigen 1 peptide-based vaccine delivered intraperitoneally with polyriboinosinic:polyribocytidylic acid as an adjuvant.	Poly C	291-313	integrin subunit alpha E	Homo sapiens	36-41
31648143-5	2019	Here we hypothesised that maternal immune activation induced in pregnant rats by polyinosinic:polycytidylic acid would alter SST and GAD gene expression as well as increase the density of GAD-positive IWMNs in the adult offspring.	Poly C	94-112	somatostatin	Rattus norvegicus	125-128
31648143-5	2019	Here we hypothesised that maternal immune activation induced in pregnant rats by polyinosinic:polycytidylic acid would alter SST and GAD gene expression as well as increase the density of GAD-positive IWMNs in the adult offspring.	Poly C	94-112	glutamate decarboxylase 1	Homo sapiens	133-136
31648143-5	2019	Here we hypothesised that maternal immune activation induced in pregnant rats by polyinosinic:polycytidylic acid would alter SST and GAD gene expression as well as increase the density of GAD-positive IWMNs in the adult offspring.	Poly C	94-112	glutamate decarboxylase 1	Homo sapiens	188-191
31648143-8	2019	This suggests that our model of maternal immune activation induced by prenatal exposure of rats to polyinosinic:polycytidylic acid during late gestation is able to recapitulate changes in SST but not other GABAergic neuropathologies observed in schizophrenia.	Poly C	112-130	somatostatin	Rattus norvegicus	188-191
31049957-3	2019	This study aimed to investigate the effect of TLR-3 agonist polyinosinic:polycytidylic acid (Poly I:C) on the expression of inflammatory markers and bone metabolism proteins by human periodontal ligament stem cells (hPDLSCs) compared with TLR-2 agonist Pam3CSK4, which mimics the effect of bacterial lipoproteins.	Poly C	73-91	toll like receptor 3	Homo sapiens	46-51
31049957-3	2019	This study aimed to investigate the effect of TLR-3 agonist polyinosinic:polycytidylic acid (Poly I:C) on the expression of inflammatory markers and bone metabolism proteins by human periodontal ligament stem cells (hPDLSCs) compared with TLR-2 agonist Pam3CSK4, which mimics the effect of bacterial lipoproteins.	Poly C	73-91	toll like receptor 2	Homo sapiens	239-244
31180720-9	2019	Further investigations suggest that ZIKV NS2B3 impairs polyinosinic:polycytidylic acid-triggered K63-linked polyubiquitination of MITA, thereby subverting the activation of downstream sensors.	Poly C	68-86	stimulator of interferon response cGAMP interactor 1	Homo sapiens	130-134
31053970-3	2019	Following injection with polyinosinic:polycytidylic acid, a mimic of viral infection, a robust hepatic innate immune response could be seen involving the TNFalpha pathway at 2 h. Repeated doses led to the adoption of Warburg-like metabolism in the liver as determined by in vivo metabolic imaging, expression analyses, and metabolomics.	Poly C	38-56	tumor necrosis factor	Homo sapiens	154-162
31160492-0	2019	The Poly(C) Motif in the Proximal Promoter Region of the D Site-Binding Protein Gene (Dbp) Drives Its High-Amplitude Oscillation.	Poly C	4-11	D-box binding PAR bZIP transcription factor	Homo sapiens	57-79
31160492-0	2019	The Poly(C) Motif in the Proximal Promoter Region of the D Site-Binding Protein Gene (Dbp) Drives Its High-Amplitude Oscillation.	Poly C	4-11	D-box binding PAR bZIP transcription factor	Homo sapiens	86-89
31160492-3	2019	Here, we demonstrated that the poly(C) motif within the Dbp proximal promoter, in addition to an E-box element, provoked transcriptional activation.	Poly C	31-38	D-box binding PAR bZIP transcription factor	Homo sapiens	56-59
31160492-4	2019	Furthermore, we generated a cell line with poly(C) deleted to demonstrate the endogenous effect of the poly(C) motif within the Dbp promoter.	Poly C	103-110	D-box binding PAR bZIP transcription factor	Homo sapiens	128-131
31160492-6	2019	Next, assay for transposase-accessible chromatin (ATAC)-quantitative PCR (qPCR) showed that the poly(C) motif induced greater chromatin accessibility within the region of the Dbp promoter.	Poly C	96-103	D-box binding PAR bZIP transcription factor	Homo sapiens	175-178
31160492-7	2019	Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms.	Poly C	99-105	D-box binding PAR bZIP transcription factor	Homo sapiens	68-71
31160492-7	2019	Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms.	Poly C	99-105	D-box binding PAR bZIP transcription factor	Homo sapiens	205-208
31160492-7	2019	Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms.	Poly C	99-105	D-box binding PAR bZIP transcription factor	Homo sapiens	205-208
31160492-7	2019	Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms.	Poly C	99-106	D-box binding PAR bZIP transcription factor	Homo sapiens	68-71
31160492-7	2019	Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms.	Poly C	99-106	D-box binding PAR bZIP transcription factor	Homo sapiens	205-208
31160492-7	2019	Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms.	Poly C	99-106	D-box binding PAR bZIP transcription factor	Homo sapiens	205-208
31333667-3	2019	The present study was conducted to determine whether selected lactic acid bacteria (LAB) modulate toll-like receptor 3 (TLR3) agonist polyinosinic:polycytidylic acid (PolyI:C) induced viral response in human intestinal epithelial cells (IECs).	Poly C	147-165	toll like receptor 3	Homo sapiens	98-118
31333667-3	2019	The present study was conducted to determine whether selected lactic acid bacteria (LAB) modulate toll-like receptor 3 (TLR3) agonist polyinosinic:polycytidylic acid (PolyI:C) induced viral response in human intestinal epithelial cells (IECs).	Poly C	147-165	toll like receptor 3	Homo sapiens	120-124
31384667-5	2019	Further expansion of tumor-resident CD103+ DCs by injecting the FMS-related tyrosine kinase 3 ligand, the formative cytokine for CD103+ DCs, provided a platform for a booster immunization with the Wilms tumor antigen 1 peptide-based vaccine delivered intraperitoneally with polyriboinosinic:polyribocytidylic acid as an adjuvant.	Poly C	291-313	fms related receptor tyrosine kinase 3 ligand	Homo sapiens	64-100
31110205-1	2019	We have previously identified a novel Aurora-A-mediated Serine 379 (S379) phosphorylation of a poly(C)-binding protein, hnRNPK, the overexpression of which is frequently observed in various cancers.	Poly C	95-102	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	120-126
30387134-3	2019	Herein, we tested whether the TLR3 agonist polyinosinic: polycytidylic acid (poly I:C) can improve chemotherapeutic efficacy in paclitaxel (PTX) resistant cell lines.	Poly C	57-75	toll like receptor 3	Homo sapiens	30-34
30387134-3	2019	Herein, we tested whether the TLR3 agonist polyinosinic: polycytidylic acid (poly I:C) can improve chemotherapeutic efficacy in paclitaxel (PTX) resistant cell lines.	Poly C	77-85	toll like receptor 3	Homo sapiens	30-34
30387134-9	2019	In conclusion, our studies demonstrate that poly I:C reinforces the potency of cytotoxic chemotherapeutics in PTX-resistant cell line through the TLR3-UNC93B1-IFN-beta signaling pathway, which supplies a novel mechanism of poly I:C for the chemotherapy sensitizing effect in a PTX-resistant tumor.	Poly C	223-231	interferon beta 1	Homo sapiens	159-167
30387134-7	2019	Moreover, cotreatment of poly I:C and PTX acted synergistically to induce cell apoptosis of HCT-8/PTX via upregulating the expression of TLR3 and its molecular chaperone UNC93B1, assisting in the secretion of IFN-beta.	Poly C	25-33	toll like receptor 3	Homo sapiens	137-141
30387134-7	2019	Moreover, cotreatment of poly I:C and PTX acted synergistically to induce cell apoptosis of HCT-8/PTX via upregulating the expression of TLR3 and its molecular chaperone UNC93B1, assisting in the secretion of IFN-beta.	Poly C	25-33	unc-93 homolog B1, TLR signaling regulator	Homo sapiens	170-177
30387134-7	2019	Moreover, cotreatment of poly I:C and PTX acted synergistically to induce cell apoptosis of HCT-8/PTX via upregulating the expression of TLR3 and its molecular chaperone UNC93B1, assisting in the secretion of IFN-beta.	Poly C	25-33	interferon beta 1	Homo sapiens	209-217
30387134-9	2019	In conclusion, our studies demonstrate that poly I:C reinforces the potency of cytotoxic chemotherapeutics in PTX-resistant cell line through the TLR3-UNC93B1-IFN-beta signaling pathway, which supplies a novel mechanism of poly I:C for the chemotherapy sensitizing effect in a PTX-resistant tumor.	Poly C	44-52	toll like receptor 3	Homo sapiens	146-150
30387134-9	2019	In conclusion, our studies demonstrate that poly I:C reinforces the potency of cytotoxic chemotherapeutics in PTX-resistant cell line through the TLR3-UNC93B1-IFN-beta signaling pathway, which supplies a novel mechanism of poly I:C for the chemotherapy sensitizing effect in a PTX-resistant tumor.	Poly C	44-52	unc-93 homolog B1, TLR signaling regulator	Homo sapiens	151-158
30387134-9	2019	In conclusion, our studies demonstrate that poly I:C reinforces the potency of cytotoxic chemotherapeutics in PTX-resistant cell line through the TLR3-UNC93B1-IFN-beta signaling pathway, which supplies a novel mechanism of poly I:C for the chemotherapy sensitizing effect in a PTX-resistant tumor.	Poly C	44-52	interferon beta 1	Homo sapiens	159-167
30387134-9	2019	In conclusion, our studies demonstrate that poly I:C reinforces the potency of cytotoxic chemotherapeutics in PTX-resistant cell line through the TLR3-UNC93B1-IFN-beta signaling pathway, which supplies a novel mechanism of poly I:C for the chemotherapy sensitizing effect in a PTX-resistant tumor.	Poly C	223-231	toll like receptor 3	Homo sapiens	146-150
30550930-2	2019	Activation of toll-like receptor 3 (TLR3) by polyinosinic:polycytidylic acid (poly(I:C)) produced a rapid proinflammatory response in males that increased alcohol intake over time (Warden et al., 2019).	Poly C	58-76	toll-like receptor 3	Mus musculus	14-34
31016183-8	2019	After DHV-1 injection or poly I:C treatment, du SERPINA1 mRNA was up-regulated in the liver and kidney tissues.	Poly C	25-33	alpha-1-antitrypsin	Anas platyrhynchos	48-56
30550930-2	2019	Activation of toll-like receptor 3 (TLR3) by polyinosinic:polycytidylic acid (poly(I:C)) produced a rapid proinflammatory response in males that increased alcohol intake over time (Warden et al., 2019).	Poly C	58-76	toll-like receptor 3	Mus musculus	36-40
30550931-6	2019	To test the possibility TLR3 activation regulates alcohol consumption, we injected mice with the TLR3 agonist polyinosinic:polycytidylic acid (poly(I:C)) and tested alcohol consumption in an every-other-day two-bottle choice test.	Poly C	123-141	toll-like receptor 3	Mus musculus	97-101
30478640-7	2019	RESULTS: DEXI-silenced beta cells exposed to a synthetic double-stranded RNA (polyinosinic:polycytidylic acid [PIC], a by-product of viral replication) showed reduced activation of signal transducer and activator of transcription (STAT) 1 and lower production of proinflammatory chemokines that was preceded by a reduction in IFNbeta levels.	Poly C	91-109	Dexi homolog	Homo sapiens	9-13
30478640-7	2019	RESULTS: DEXI-silenced beta cells exposed to a synthetic double-stranded RNA (polyinosinic:polycytidylic acid [PIC], a by-product of viral replication) showed reduced activation of signal transducer and activator of transcription (STAT) 1 and lower production of proinflammatory chemokines that was preceded by a reduction in IFNbeta levels.	Poly C	91-109	signal transducer and activator of transcription 1	Homo sapiens	181-238
30153047-10	2019	We also observed that ZL0454 treatment blocked polyinosinic:polycytidylic acid-associated expansion of the alpha-SMA1+/COL1A+ myofibroblast population and prevented myofibroblast transition in a coculture system.	Poly C	60-78	survival of motor neuron 1, telomeric	Homo sapiens	113-117
30590162-4	2019	For the genes related to inflammation, viperin, Mx and Toll like receptor 3 (TLR3), transcription were significantly upregulated by poly I:C in head kidney cells, while viperin was upregulated in liver cells.	Poly C	132-140	toll-like receptor 3	Salmo salar	55-75
30590162-4	2019	For the genes related to inflammation, viperin, Mx and Toll like receptor 3 (TLR3), transcription were significantly upregulated by poly I:C in head kidney cells, while viperin was upregulated in liver cells.	Poly C	132-140	toll-like receptor 3	Salmo salar	77-81
30530482-5	2019	Through viral infection, polyinosinic:polycytidylic acid and RIG-I-like receptor factor stimulation upregulated IFN expression, but overexpression of MVP significantly subverted these inductions.	Poly C	38-56	interferon phi 1	Danio rerio	112-115
30723476-6	2018	Treatment with the TLR3 ligand polyinosinic: polycytidylic acid [Poly(I:C)] did not affect GILZ mRNA levels, although GILZ protein expression was decreased.	Poly C	45-63	toll like receptor 3	Homo sapiens	19-23
30075247-5	2018	Following poly I:C challenge, the expression levels of TRAF3 and TRAF6 were highest in the kidneys and lowest in the spleen, whereas after infection with V. anguillarum, TRAF6 expression was the highest in the kidneys and lowest in the liver.	Poly C	10-18	TNF receptor-associated factor 3	Larimichthys crocea	55-60
30518569-6	2019	As has been described in other cell types, nc886 bound to PKR in human T cell lysates, preventing PKR phosphorylation by polyinosinic:polycytidylic acid or HIV trans-activation response element RNA in lysates of T cell lines or primary human CD4+ T cells.	Poly C	134-152	vault RNA 2-1	Homo sapiens	43-48
30518569-6	2019	As has been described in other cell types, nc886 bound to PKR in human T cell lysates, preventing PKR phosphorylation by polyinosinic:polycytidylic acid or HIV trans-activation response element RNA in lysates of T cell lines or primary human CD4+ T cells.	Poly C	134-152	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	58-61
30075247-5	2018	Following poly I:C challenge, the expression levels of TRAF3 and TRAF6 were highest in the kidneys and lowest in the spleen, whereas after infection with V. anguillarum, TRAF6 expression was the highest in the kidneys and lowest in the liver.	Poly C	10-18	TNF receptor-associated factor 6	Larimichthys crocea	65-70
30363688-7	2018	Using a luciferase assay, the proinflammatory cytokines IL-1beta and TNF, and viral analogue polyinosinic : polycytidylic acid (poly(I : C)) significantly reduced SMAD3 transcriptional activity in human primary myometrial cells.	Poly C	108-126	SMAD family member 3	Homo sapiens	163-168
30224514-5	2018	In this study, we have shown that polyinosinic:polycytidylic acid (polyI:C) and influenza A virus (IAV) infection increased IFN-lambda expression at mRNA and protein levels in primary cultures of normal human bronchial epithelial cells, whereas IL-17A attenuated polyI:C- or IAV-induced IFN-lambda expression.	Poly C	47-65	interferon alpha 1	Homo sapiens	124-127
30224514-5	2018	In this study, we have shown that polyinosinic:polycytidylic acid (polyI:C) and influenza A virus (IAV) infection increased IFN-lambda expression at mRNA and protein levels in primary cultures of normal human bronchial epithelial cells, whereas IL-17A attenuated polyI:C- or IAV-induced IFN-lambda expression.	Poly C	47-65	interleukin 17A	Homo sapiens	245-251
30224514-5	2018	In this study, we have shown that polyinosinic:polycytidylic acid (polyI:C) and influenza A virus (IAV) infection increased IFN-lambda expression at mRNA and protein levels in primary cultures of normal human bronchial epithelial cells, whereas IL-17A attenuated polyI:C- or IAV-induced IFN-lambda expression.	Poly C	47-65	interferon alpha 1	Homo sapiens	287-290
30063728-7	2018	We found that addition of the TLR3 agonist, polyinosinic:polycytidylic acid (Poly(I:C)) to either one of the Mincle receptor agonists, TDB or monomycoloyl glycerol (MMG), enhanced monocyte activation, and calves vaccinated with CAF09 containing MMG and Poly(I:C) had increased cell-mediated and humoral immune response compared to CAF01 vaccinated animals.	Poly C	57-75	toll like receptor 3	Bos taurus	30-34
29933111-7	2018	Moreover, we found that On-TRAF6 was involved immune response of Nile tilapia following the stimulation with Streptococcus agalactiae and polyinosinic: polycytidylic acid (Poly I:C) when determined by using qPCR.	Poly C	172-180	TNF receptor-associated factor 6	Oreochromis niloticus	27-32
30063728-7	2018	We found that addition of the TLR3 agonist, polyinosinic:polycytidylic acid (Poly(I:C)) to either one of the Mincle receptor agonists, TDB or monomycoloyl glycerol (MMG), enhanced monocyte activation, and calves vaccinated with CAF09 containing MMG and Poly(I:C) had increased cell-mediated and humoral immune response compared to CAF01 vaccinated animals.	Poly C	57-75	C-type lectin domain family 4 member E	Bos taurus	109-115
29866654-0	2018	Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript.	Poly C	0-7	poly(rC) binding protein 2	Homo sapiens	24-29
29866654-0	2018	Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript.	Poly C	0-7	RUNX family transcription factor 1	Homo sapiens	123-128
29891675-3	2018	We herein report that the poly(C)-binding protein PCBP1 binds to more severely oxidized RNA to activate apoptosis-related reactions.	Poly C	26-33	poly(rC) binding protein 1	Homo sapiens	50-55
29146047-4	2018	RESULTS: Prenatal exposure to polyinosinic:polycytidylic acid causes an imbalanced expression of the Na+-K+-2Cl- cotransporter 1 and the K+-Cl- cotransporter 2 (KCC2).	Poly C	43-61	solute carrier family 12, member 5	Mus musculus	137-159
29146047-4	2018	RESULTS: Prenatal exposure to polyinosinic:polycytidylic acid causes an imbalanced expression of the Na+-K+-2Cl- cotransporter 1 and the K+-Cl- cotransporter 2 (KCC2).	Poly C	43-61	solute carrier family 12, member 5	Mus musculus	161-165
29277364-7	2018	Here we report the clear induction of sb-isg15 transcript levels in SAF-1 cells and AGs stimulated with toll-like receptor (TLR) ligands, such as polyinosinic:polycytidylic acid (poly I:C) or genomic DNA from Vibrio anguillarum (VaDNA), respectively.	Poly C	159-177	ISG15 ubiquitin like modifier	Homo sapiens	41-46
28921679-3	2018	This study systematically investigated how maternal immune activation (MIA; a risk factor for schizophrenia) induced by polyinosinic:polycytidylic acid affected nNOS-immunoreactivity in the brain of the resulting male and female offspring at the age of postnatal day (PND) 2.	Poly C	133-151	nitric oxide synthase 1	Rattus norvegicus	161-165
28849057-1	2017	The present study aimed to determine the underlying mechanism of toll-like receptor (TLR) agonist polyinosinic:polycytidylic acid (Poly I:C)-induced apoptosis in THP-1 cells following silencing the expression of tumor necrosis factor alpha-induced protein 8-like 2 (TIPE2).	Poly C	111-129	TNF alpha induced protein 8 like 2	Homo sapiens	212-264
27086952-3	2017	Polyriboinosinic:polyribocytidylic acid (poly (I:C)), a synthetic analog of viral RNA, induces a Toll-like receptor 3 (TLR3)-dependent arteriolar thrombosis without significant thrombus formation in venules in vivo.	Poly C	17-39	toll like receptor 3	Homo sapiens	97-117
27086952-3	2017	Polyriboinosinic:polyribocytidylic acid (poly (I:C)), a synthetic analog of viral RNA, induces a Toll-like receptor 3 (TLR3)-dependent arteriolar thrombosis without significant thrombus formation in venules in vivo.	Poly C	17-39	toll like receptor 3	Homo sapiens	119-123
28978569-7	2017	Although recipient exposure to the viral-like adjuvant polyinosinic:polycytidylic acid enhanced anti-FVIII antibody formation, MZ B-cell depletion continued to display similar effectiveness in preventing inhibitor formation following FVIII infusion in this inflammatory setting.	Poly C	68-86	coagulation factor VIII	Homo sapiens	101-106
28974092-3	2017	Here, we investigated the ability of chitosan-based nanoparticles (pIC-NPs) containing polyinosinic-polycytidylic acid (poly(I:C)), an inducer of innate immunity via Toll-like receptor 3 (TLR3), to enhance the immunogenicity of BCG in mouse bone marrow derived macrophages (BMDM) in vitro.	Poly C	99-118	toll-like receptor 3	Mus musculus	166-186
28849057-1	2017	The present study aimed to determine the underlying mechanism of toll-like receptor (TLR) agonist polyinosinic:polycytidylic acid (Poly I:C)-induced apoptosis in THP-1 cells following silencing the expression of tumor necrosis factor alpha-induced protein 8-like 2 (TIPE2).	Poly C	111-129	TNF alpha induced protein 8 like 2	Homo sapiens	266-271
28717003-2	2017	Double-stranded RNA and the synthetic analog polyinosinic:polycytidylic acid (poly(I:C)) bind and activate TLR3.	Poly C	58-76	toll like receptor 3	Homo sapiens	107-111
28466996-3	2017	METHOD OF STUDY: The aims of this study were to determine the effect of: (i) viral dsRNA analogue polyinosinic:polycytidylic acid (poly(I:C)) on HAVCR2 expression; and (ii) HAVCR2 silencing by siRNA (siHAVCR2) in primary amnion and myometrial cells on poly(I:C)-induced inflammation.	Poly C	111-129	hepatitis A virus cellular receptor 2	Homo sapiens	145-151
28809156-0	2017	The length of poly(C) stretch in the Bordetella pertussis Pfim3 promoter determines the vag or vrg function of the fim3 gene.	Poly C	14-21	FIM3	Homo sapiens	59-63
28809156-2	2017	The expression of fim2 and fim3 is regulated by the BvgAS two-component system and the length of poly(C) stretches in Pfim promoters.	Poly C	97-104	colony stimulating factor 1 receptor	Homo sapiens	18-22
28809156-2	2017	The expression of fim2 and fim3 is regulated by the BvgAS two-component system and the length of poly(C) stretches in Pfim promoters.	Poly C	97-104	FIM3	Homo sapiens	27-31
28809156-6	2017	Our findings indicate that fim2 is a vag, while fim3 is a vag when Pfim3 poly(C)&gt;13C, and a vrg when poly(C)&lt;=13C.	Poly C	73-79	FIM3	Homo sapiens	48-52
28809156-6	2017	Our findings indicate that fim2 is a vag, while fim3 is a vag when Pfim3 poly(C)&gt;13C, and a vrg when poly(C)&lt;=13C.	Poly C	104-110	FIM3	Homo sapiens	48-52
28809156-7	2017	Although increased fim3 expression was observed in the Bvg- phase in isolates with Pfim3 poly(C)&lt;=13C, Fim3 production was not detected, suggesting post-transcriptional regulation of fim3 expression.	Poly C	89-95	FIM3	Homo sapiens	19-23
28809156-7	2017	Although increased fim3 expression was observed in the Bvg- phase in isolates with Pfim3 poly(C)&lt;=13C, Fim3 production was not detected, suggesting post-transcriptional regulation of fim3 expression.	Poly C	89-95	FIM3	Homo sapiens	84-88
28381556-0	2017	Poly(C)-binding protein 1 (Pcbp1) regulates skeletal muscle differentiation by modulating microRNA processing in myoblasts.	Poly C	0-6	poly(rC) binding protein 1	Mus musculus	27-32
28331190-9	2017	Moreover, we found that IFN-gamma production from NK cells was essential for the antiviral effect of PolyI:C in the model.	Poly C	101-108	interferon gamma	Homo sapiens	24-33
27649928-3	2017	Intraperitoneally injected polyribocytidylic acid (poly (I:C)- (a ligand of TLR3) primed human umbilical cord-derived MSCs (hUC-MSCs) migrated to the inflamed colon and effectively improved clinical and pathological manifestations in colitic mice compared with mice treated with unstimulated hUC-MSCs (UCMs).	Poly C	27-49	toll like receptor 3	Homo sapiens	76-80
28411188-3	2017	RKIP deficiency or silencing significantly decreases polyinosinic:polycytidylic acid [Poly(I:C)]-induced IFN-beta, IL-6, and TNF-alpha production without affecting the counterpart induced by LPS or CpG.	Poly C	66-84	interferon beta 1, fibroblast	Mus musculus	105-113
28411188-3	2017	RKIP deficiency or silencing significantly decreases polyinosinic:polycytidylic acid [Poly(I:C)]-induced IFN-beta, IL-6, and TNF-alpha production without affecting the counterpart induced by LPS or CpG.	Poly C	66-84	interleukin 6	Mus musculus	115-119
28411188-3	2017	RKIP deficiency or silencing significantly decreases polyinosinic:polycytidylic acid [Poly(I:C)]-induced IFN-beta, IL-6, and TNF-alpha production without affecting the counterpart induced by LPS or CpG.	Poly C	66-84	tumor necrosis factor	Mus musculus	125-134
27911568-3	2017	Although acute activation of the Toll-like receptor (TLR) 3 pathway by extracellular polyinosinic:polycytidylic acid (poly[I:C]) induces innate signaling through the NF-kappaB transcription factor in normal human small airway epithelial cells, prolonged (repetitive or tonic) poly(I:C) stimulation produces chronic stress fiber formation, mesenchymal transition, and activation of a fibrotic program.	Poly C	98-116	nuclear factor kappa B subunit 1	Homo sapiens	166-175
28149670-9	2016	Injection with polyinosinic: polycytidylic acid (poly I:C), a synthetic analogue of double stranded viral RNA that binds Toll-Like Receptor-3 (TLR3), also regulated gene expressions of CCKAR and proinflammatory cytokines, in the different breeds.	Poly C	49-57	toll like receptor 3	Gallus gallus	121-141
28266599-6	2017	After stimulation of ORS cells with the double-stranded (ds)RNA mimic polyinosinic:polycytidylic acid (poly[I:C]), the activation of caspase-1 and secretion of IL-1beta were enhanced.	Poly C	83-101	caspase 1	Homo sapiens	133-142
28266599-6	2017	After stimulation of ORS cells with the double-stranded (ds)RNA mimic polyinosinic:polycytidylic acid (poly[I:C]), the activation of caspase-1 and secretion of IL-1beta were enhanced.	Poly C	83-101	interleukin 1 beta	Homo sapiens	160-168
29204085-4	2017	In this study we demonstrate that IC or intravenous immunoglobulin (Ig) stimulation of B cells attenuates polyinosinic:polycytidylic acid (poly I:C)-induced CD40 expression; IC, but not Ig, can significantly inhibit poly I:C-induced pro-inflammatory tumour necrosis factor alpha (TNF-alpha) production by B cells.	Poly C	119-137	CD40 molecule	Homo sapiens	157-161
29204085-4	2017	In this study we demonstrate that IC or intravenous immunoglobulin (Ig) stimulation of B cells attenuates polyinosinic:polycytidylic acid (poly I:C)-induced CD40 expression; IC, but not Ig, can significantly inhibit poly I:C-induced pro-inflammatory tumour necrosis factor alpha (TNF-alpha) production by B cells.	Poly C	119-137	tumor necrosis factor	Homo sapiens	280-289
28272528-6	2017	Degradation of Poly(A), Poly(C), Poly(G), Poly(I), Poly(T), and Poly(U) oligomers in the presence of EGFR and ATP correlated with the lower ability of reaction products to pair with complementary oligonucleotides.	Poly C	24-30	epidermal growth factor receptor	Homo sapiens	101-105
28292465-3	2017	Thus, the aims of this study were to determine the effect of the bacterial product lipopolysaccharide (LPS) or the viral dsRNA analogue polyinosinic:polycytidylic acid (poly(I:C)) on the insulin signalling pathway and amino acid transport in primary human trophoblast cells.	Poly C	149-167	insulin	Homo sapiens	187-194
28149670-9	2016	Injection with polyinosinic: polycytidylic acid (poly I:C), a synthetic analogue of double stranded viral RNA that binds Toll-Like Receptor-3 (TLR3), also regulated gene expressions of CCKAR and proinflammatory cytokines, in the different breeds.	Poly C	49-57	toll like receptor 3	Gallus gallus	143-147
28149670-9	2016	Injection with polyinosinic: polycytidylic acid (poly I:C), a synthetic analogue of double stranded viral RNA that binds Toll-Like Receptor-3 (TLR3), also regulated gene expressions of CCKAR and proinflammatory cytokines, in the different breeds.	Poly C	49-57	cholecystokinin A receptor	Gallus gallus	185-190
27748915-1	2016	Poly(C)-binding protein 2 (PCBP2) is a member of the PCBP family, and plays an important role in post-transcriptional and translational regulation of various signaling molecules through direct binding to single-stranded poly(C) motifs.	Poly C	220-227	poly(rC) binding protein 2	Homo sapiens	0-25
27748915-1	2016	Poly(C)-binding protein 2 (PCBP2) is a member of the PCBP family, and plays an important role in post-transcriptional and translational regulation of various signaling molecules through direct binding to single-stranded poly(C) motifs.	Poly C	220-227	poly(rC) binding protein 2	Homo sapiens	27-32
27623813-9	2016	Notably, polyinosinic:polycytidylic acid induced nuclear localization of iNOS, and its binding to, and nitrosylation of, the epigenetic modifier ring finger protein 1A (RING1A) as assessed by immunostaining, Co-IP, and mass spectrometry.	Poly C	22-40	nitric oxide synthase 2, inducible	Mus musculus	73-77
27623813-9	2016	Notably, polyinosinic:polycytidylic acid induced nuclear localization of iNOS, and its binding to, and nitrosylation of, the epigenetic modifier ring finger protein 1A (RING1A) as assessed by immunostaining, Co-IP, and mass spectrometry.	Poly C	22-40	ring finger protein 1	Mus musculus	145-167
27623813-9	2016	Notably, polyinosinic:polycytidylic acid induced nuclear localization of iNOS, and its binding to, and nitrosylation of, the epigenetic modifier ring finger protein 1A (RING1A) as assessed by immunostaining, Co-IP, and mass spectrometry.	Poly C	22-40	ring finger protein 1	Mus musculus	169-175
27601297-6	2016	Moreover, Ec-MKK7 was universally expressed in all examined tissues and showed expression modulation to challenges of lipopolysacchride (LPS), Singapore grouper iridovirus (SGIV) and polyriboinosinic polyribocytidylic acid (poly I:C) in vivo.	Poly C	224-232	mitogen-activated protein kinase kinase 7	Homo sapiens	13-17
27412245-16	2016	MAIN RESULTS AND THE ROLE OF CHANCE: Our results showed that addition of polyinosinic:polycytidylic acid (Poly I:C) to RL95-2 cells significantly increased the production of IL-1RA (P &lt; 0.05).	Poly C	86-104	interleukin 1 receptor antagonist	Homo sapiens	174-180
27603520-3	2016	The long double-stranded RNA (dsRNA) viral mimic, polyinosinic polycytidylic acid (polyIC, PIC) potently stimulates DCs to focus Th1 responses, triggers direct antiviral activity in vitro, and boosts anti-HIV responses in vivo.	Poly C	83-89	negative elongation factor complex member C/D	Homo sapiens	129-132
27373927-4	2016	We present here two of these issues related to the use of Mx1-Cre: first, a high spontaneous recombination rate when applying commonly used techniques in experimental hematology, and second, undesired short-term consequences of the use of polyinosinic:polycytidylic acid, including changes in cellular phenotypes that, however, resolve within days.	Poly C	252-270	MX dynamin-like GTPase 1	Mus musculus	58-61
27621733-8	2016	IFNalpha/beta increase HSC proliferation in models of sterile inflammation induced by polyinosinic:polycytidylic acid and lead to BM aplasia during viral infection.	Poly C	99-117	interferon alpha 1	Homo sapiens	0-8
27461833-0	2016	Poly (C)-binding protein 2 (PCBP2) promotes the progression of esophageal squamous cell carcinoma (ESCC) through regulating cellular proliferation and apoptosis.	Poly C	0-7	poly(rC) binding protein 2	Homo sapiens	28-33
27461833-1	2016	PCBP2 (Poly(C)-binding protein 2) is a member of PCBP family, which has many functions including mRNA stabilization, translational silence and translational enhancement performed by their poly(C)-binding ability.	Poly C	188-195	poly(rC) binding protein 2	Homo sapiens	0-5
27461833-1	2016	PCBP2 (Poly(C)-binding protein 2) is a member of PCBP family, which has many functions including mRNA stabilization, translational silence and translational enhancement performed by their poly(C)-binding ability.	Poly C	188-195	poly(rC) binding protein 2	Homo sapiens	7-32
27209304-1	2016	PCBP2, a member of the poly(C)-binding protein (PCBP) family, plays a pivotal role in posttranscriptional and translational regulation by interacting with single-stranded poly(C) motifs in target mRNAs.	Poly C	23-30	poly(rC) binding protein 2	Homo sapiens	0-5
27198486-2	2016	We found that Toll-like receptor (TLR) stimuli, particularly the viral mimetic polyinosinic:polycytidylic acid (poly(I:C)), specifically induce ApoLs7/11 subfamilies in murine CD8alpha(+)  dendritic cells (DCs).	Poly C	92-110	CD8 antigen, alpha chain	Mus musculus	176-184
27327127-6	2016	The MDA5 promoter activity was extremely low under basal condition, but was dramatically increased when cells were stimulated with polyinosinic: polycytidylic acid (poly I:C), interferon beta (IFN-beta) or Infectious Bursal Disease Virus (IBDV).	Poly C	165-173	interferon induced with helicase C domain 1	Gallus gallus	4-8
26935338-3	2016	In addition, Muc1 + polyinosinic:polycytidylic acid (poly I:C) was found to stimulate the expression levels of the surface molecules cluster of differentiation (CD)40, CD83 and CD80, and HLA-DRm and decreased the expression of CD14 in the dendritic cells, determined using fluorescence-activated cell sorting.	Poly C	33-51	mucin 1, cell surface associated	Homo sapiens	13-17
27151946-5	2016	The effects of p31-43 were dependent on MyD88 and type I IFNs, but not Toll-like receptor 4 (TLR4), and were enhanced by coadministration of the TLR3 agonist polyinosinic:polycytidylic acid.	Poly C	171-189	unconventional SNARE in the ER 1 homolog (S. cerevisiae)	Mus musculus	15-18
27151946-5	2016	The effects of p31-43 were dependent on MyD88 and type I IFNs, but not Toll-like receptor 4 (TLR4), and were enhanced by coadministration of the TLR3 agonist polyinosinic:polycytidylic acid.	Poly C	171-189	toll-like receptor 3	Mus musculus	145-149
26994222-4	2016	First, the upregulation of IFNphi1 promoter activity stimulated by polyinosinic:polycytidylic acid, retinoic acid-inducible gene I (RIG-I) or MAVS was suppressed by the SVCV infection.	Poly C	80-98	interferon phi 1	Danio rerio	27-34
26880484-1	2016	Accumulating evidences indicate that poly C binding protein (PCBP1) is downregulated in various carcinomas as a tumor suppressor, but the underlying mechanism in suppression of tumorigenesis still remains elusive.	Poly C	37-43	poly(rC) binding protein 1	Homo sapiens	61-66
26935338-3	2016	In addition, Muc1 + polyinosinic:polycytidylic acid (poly I:C) was found to stimulate the expression levels of the surface molecules cluster of differentiation (CD)40, CD83 and CD80, and HLA-DRm and decreased the expression of CD14 in the dendritic cells, determined using fluorescence-activated cell sorting.	Poly C	33-51	CD83 molecule	Homo sapiens	168-172
26935338-3	2016	In addition, Muc1 + polyinosinic:polycytidylic acid (poly I:C) was found to stimulate the expression levels of the surface molecules cluster of differentiation (CD)40, CD83 and CD80, and HLA-DRm and decreased the expression of CD14 in the dendritic cells, determined using fluorescence-activated cell sorting.	Poly C	33-51	CD80 molecule	Homo sapiens	177-181
26935338-3	2016	In addition, Muc1 + polyinosinic:polycytidylic acid (poly I:C) was found to stimulate the expression levels of the surface molecules cluster of differentiation (CD)40, CD83 and CD80, and HLA-DRm and decreased the expression of CD14 in the dendritic cells, determined using fluorescence-activated cell sorting.	Poly C	33-51	CD14 molecule	Homo sapiens	227-231
26744891-0	2016	Correction: Human beta-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid.	Poly C	124-142	toll like receptor 3	Homo sapiens	59-63
26674566-6	2016	The proinflammatory cytokine IL1B, the bacterial product fsl-1, and viral analog polyinosinic:polycytidylic acid (poly [I:C]) significantly increased IRF1 mRNA expression and transcriptional activity in human primary myometrial cells.	Poly C	94-112	interleukin 1 beta	Homo sapiens	29-33
26674566-6	2016	The proinflammatory cytokine IL1B, the bacterial product fsl-1, and viral analog polyinosinic:polycytidylic acid (poly [I:C]) significantly increased IRF1 mRNA expression and transcriptional activity in human primary myometrial cells.	Poly C	94-112	interferon regulatory factor 1	Homo sapiens	150-154
26759009-5	2016	In this study, we analyzed the potential of polyinosinic:polycytidylic acid [poly(I:C)], a TLR3 agonist, to replace or complement BCG in the treatment of non-muscle-invasive bladder cancer.	Poly C	57-75	toll like receptor 3	Homo sapiens	91-95
26293996-1	2015	BACKGROUND: Depletion of Poly-C binding protein-1(PCBP1) is implicated in various human malignancies.	Poly C	25-31	poly(rC) binding protein 1	Homo sapiens	50-55
26659307-6	2015	RESULTS: Polyinosinic:polycytidylic acid transfection led to elevated expression of the genes encoding IFNalpha, IFNbeta, CXCL10, Fas, viral receptors, and IFN-inducible antiviral effectors in MIN6 cells.	Poly C	22-40	interferon alpha	Mus musculus	103-111
26659307-6	2015	RESULTS: Polyinosinic:polycytidylic acid transfection led to elevated expression of the genes encoding IFNalpha, IFNbeta, CXCL10, Fas, viral receptors, and IFN-inducible antiviral effectors in MIN6 cells.	Poly C	22-40	interferon beta 1, fibroblast	Mus musculus	113-120
26659307-6	2015	RESULTS: Polyinosinic:polycytidylic acid transfection led to elevated expression of the genes encoding IFNalpha, IFNbeta, CXCL10, Fas, viral receptors, and IFN-inducible antiviral effectors in MIN6 cells.	Poly C	22-40	chemokine (C-X-C motif) ligand 10	Mus musculus	122-128
26573531-0	2015	PHF11 expression and cellular distribution is regulated by the Toll-Like Receptor 3 Ligand Polyinosinic:Polycytidylic Acid in HaCaT keratinocytes.	Poly C	104-122	PHD finger protein 11	Homo sapiens	0-5
26573531-0	2015	PHF11 expression and cellular distribution is regulated by the Toll-Like Receptor 3 Ligand Polyinosinic:Polycytidylic Acid in HaCaT keratinocytes.	Poly C	104-122	toll like receptor 3	Homo sapiens	63-83
26722446-1	2015	PCBP2, a member of the poly(C)-binding protein (PCBP) family, is involved in posttranscriptional and translational regulation by interacting with single-stranded poly(C) motifs in target mRNAs.	Poly C	23-30	poly(rC) binding protein 2	Homo sapiens	0-5
26283481-0	2015	Stimulation of the RIG-I/MAVS Pathway by Polyinosinic:Polycytidylic Acid Upregulates IFN-beta in Airway Epithelial Cells with Minimal Costimulation of IL-8.	Poly C	54-72	DExD/H-box helicase 58	Homo sapiens	19-24
26283481-0	2015	Stimulation of the RIG-I/MAVS Pathway by Polyinosinic:Polycytidylic Acid Upregulates IFN-beta in Airway Epithelial Cells with Minimal Costimulation of IL-8.	Poly C	54-72	mitochondrial antiviral signaling protein	Homo sapiens	25-29
26283481-0	2015	Stimulation of the RIG-I/MAVS Pathway by Polyinosinic:Polycytidylic Acid Upregulates IFN-beta in Airway Epithelial Cells with Minimal Costimulation of IL-8.	Poly C	54-72	interferon beta 1	Homo sapiens	85-93
26124281-5	2015	Induced ablation of SRSF2 in adult Mx1-Cre Srsf2(flox/flox) mice upon poly(I):poly(C) injection demonstrated a significant decrease in lineage(-) Sca(+) c-Kit(+) cells in bone marrow.	Poly C	78-85	serine and arginine-rich splicing factor 2	Mus musculus	20-25
26124281-5	2015	Induced ablation of SRSF2 in adult Mx1-Cre Srsf2(flox/flox) mice upon poly(I):poly(C) injection demonstrated a significant decrease in lineage(-) Sca(+) c-Kit(+) cells in bone marrow.	Poly C	78-85	MX dynamin-like GTPase 1	Mus musculus	35-38
26549174-9	2016	In gill tissues, the temporally induced mRNA expression of Of-Pis1, upon in vivo injection trials with lipopolysaccharide (LPS); polyinosinic:polycytidylic acid (poly I:C); and pathogens, including Edwardsiella tarda, Streptococcus iniae, and rock bream iridovirus (RBIV), was weak.	Poly C	142-160	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	62-66
26646717-0	2015	Human beta-Defensin 3 [corrected] Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid.	Poly C	131-149	defensin beta 103B	Homo sapiens	6-21
26646717-5	2015	HBD3 exacerbated the production of type I Interferon-beta in response to the viral ligand mimic polyinosinic:polycytidylic acid (polyI:C) in both human and mouse primary cells, although production of the chemokine CXCL10 was suppressed.	Poly C	109-127	defensin beta 103B	Homo sapiens	0-4
26646717-5	2015	HBD3 exacerbated the production of type I Interferon-beta in response to the viral ligand mimic polyinosinic:polycytidylic acid (polyI:C) in both human and mouse primary cells, although production of the chemokine CXCL10 was suppressed.	Poly C	109-127	interferon beta 1, fibroblast	Mus musculus	42-57
26527618-0	2016	The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development.	Poly C	4-11	poly(rC) binding protein 2	Mus musculus	28-33
26527618-0	2016	The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development.	Poly C	4-11	poly(rC) binding protein 1	Mus musculus	69-74
26143480-2	2015	One subgroup in mammalian cells are the Poly(C)-binding proteins (PCBPs) comprised of hnRNP K/J and hnRNP E1-4 [the latter also known as PCBP 1-4 or alpha-complex proteins (alpha-CP) 1-4].	Poly C	40-47	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	86-93
26143480-2	2015	One subgroup in mammalian cells are the Poly(C)-binding proteins (PCBPs) comprised of hnRNP K/J and hnRNP E1-4 [the latter also known as PCBP 1-4 or alpha-complex proteins (alpha-CP) 1-4].	Poly C	40-47	poly(rC) binding protein 1	Homo sapiens	100-110
26143480-2	2015	One subgroup in mammalian cells are the Poly(C)-binding proteins (PCBPs) comprised of hnRNP K/J and hnRNP E1-4 [the latter also known as PCBP 1-4 or alpha-complex proteins (alpha-CP) 1-4].	Poly C	40-47	poly(rC) binding protein 1	Homo sapiens	137-143
25488424-7	2015	Interaction analysis of polyinosinic:polycytidylic acid (poly I:C) and dsRNA depicted leucine-rich-repeats (LRR)2-3 and LRR18-19 (in TLR3) and LRRNT-LRR3 and LRR22-24 (in TLR22) as the potential binding sites.	Poly C	37-55	toll-like receptor 3	Danio rerio	133-137
26243192-3	2015	We showed that the mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK) apoptosis signal-regulating kinase 1 (ASK1) was activated in cells by the synthetic double-stranded RNA analog polyinosinic:polycytidylic acid [poly(I:C)] and by RNA viruses, and that ASK1 played an essential role in both the induction of the gene encoding IFN-beta (IFNB) and apoptotic cell death.	Poly C	206-224	mitogen-activated protein kinase kinase kinase 4	Homo sapiens	74-80
26243192-3	2015	We showed that the mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK) apoptosis signal-regulating kinase 1 (ASK1) was activated in cells by the synthetic double-stranded RNA analog polyinosinic:polycytidylic acid [poly(I:C)] and by RNA viruses, and that ASK1 played an essential role in both the induction of the gene encoding IFN-beta (IFNB) and apoptotic cell death.	Poly C	206-224	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	82-118
26243192-3	2015	We showed that the mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK) apoptosis signal-regulating kinase 1 (ASK1) was activated in cells by the synthetic double-stranded RNA analog polyinosinic:polycytidylic acid [poly(I:C)] and by RNA viruses, and that ASK1 played an essential role in both the induction of the gene encoding IFN-beta (IFNB) and apoptotic cell death.	Poly C	206-224	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	120-124
26243192-3	2015	We showed that the mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK) apoptosis signal-regulating kinase 1 (ASK1) was activated in cells by the synthetic double-stranded RNA analog polyinosinic:polycytidylic acid [poly(I:C)] and by RNA viruses, and that ASK1 played an essential role in both the induction of the gene encoding IFN-beta (IFNB) and apoptotic cell death.	Poly C	206-224	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	266-270
26243192-3	2015	We showed that the mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK) apoptosis signal-regulating kinase 1 (ASK1) was activated in cells by the synthetic double-stranded RNA analog polyinosinic:polycytidylic acid [poly(I:C)] and by RNA viruses, and that ASK1 played an essential role in both the induction of the gene encoding IFN-beta (IFNB) and apoptotic cell death.	Poly C	206-224	interferon beta 1	Homo sapiens	339-347
26243192-3	2015	We showed that the mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK) apoptosis signal-regulating kinase 1 (ASK1) was activated in cells by the synthetic double-stranded RNA analog polyinosinic:polycytidylic acid [poly(I:C)] and by RNA viruses, and that ASK1 played an essential role in both the induction of the gene encoding IFN-beta (IFNB) and apoptotic cell death.	Poly C	206-224	interferon beta 1	Homo sapiens	349-353
26125808-10	2015	Individuals challenged with infectious pancreatic necrosis virus and immunostimulated with polyinosinic:polycytidylic acid exhibited increased expression of TLR3 at the mRNA level, indicating that ssTLR3 may be involved in pathogen recognition in the early innate immune system.	Poly C	104-122	toll-like receptor 3	Salmo salar	157-161
26125808-10	2015	Individuals challenged with infectious pancreatic necrosis virus and immunostimulated with polyinosinic:polycytidylic acid exhibited increased expression of TLR3 at the mRNA level, indicating that ssTLR3 may be involved in pathogen recognition in the early innate immune system.	Poly C	104-122	toll-like receptor 3	Salmo salar	197-203
26094120-6	2015	Rhein also inhibited SRA ligand polyinosinic:polycytidylic acid (poly(I:C)) induced activation of transcriptional factors, including interferon regulatory factor 3 (IRF3) and signal transducer and activator of transcription 1 (STAT1).	Poly C	45-63	macrophage scavenger receptor 1	Homo sapiens	21-24
26094120-6	2015	Rhein also inhibited SRA ligand polyinosinic:polycytidylic acid (poly(I:C)) induced activation of transcriptional factors, including interferon regulatory factor 3 (IRF3) and signal transducer and activator of transcription 1 (STAT1).	Poly C	45-63	interferon regulatory factor 3	Homo sapiens	133-163
26094120-6	2015	Rhein also inhibited SRA ligand polyinosinic:polycytidylic acid (poly(I:C)) induced activation of transcriptional factors, including interferon regulatory factor 3 (IRF3) and signal transducer and activator of transcription 1 (STAT1).	Poly C	45-63	interferon regulatory factor 3	Homo sapiens	165-169
26094120-6	2015	Rhein also inhibited SRA ligand polyinosinic:polycytidylic acid (poly(I:C)) induced activation of transcriptional factors, including interferon regulatory factor 3 (IRF3) and signal transducer and activator of transcription 1 (STAT1).	Poly C	45-63	signal transducer and activator of transcription 1	Homo sapiens	175-225
26094120-6	2015	Rhein also inhibited SRA ligand polyinosinic:polycytidylic acid (poly(I:C)) induced activation of transcriptional factors, including interferon regulatory factor 3 (IRF3) and signal transducer and activator of transcription 1 (STAT1).	Poly C	45-63	signal transducer and activator of transcription 1	Homo sapiens	227-232
26261610-0	2015	Expression of poly(C)-binding protein 1 (PCBP1) in NSCLC as a negative regulator of EMT and its clinical value.	Poly C	14-20	poly(rC) binding protein 1	Homo sapiens	41-46
26261610-1	2015	Poly (C)-binding Protein 1 (PCBP1) is a 35 kDa protein involved in a number of biological processes.	Poly C	0-7	poly(rC) binding protein 1	Homo sapiens	28-33
25679777-4	2015	Immunization of BALB/c mice with the recombinant mAb in the presence of polyriboinosinic: polyribocytidylic acid (poly (I:C)) specifically enhanced the number of IFN-gamma producing cells and CD4+ T cell proliferation when compared to mice immunized with a mAb without receptor affinity or with the non-targeted ASP-2 protein.	Poly C	90-112	interferon gamma	Mus musculus	162-171
25679777-4	2015	Immunization of BALB/c mice with the recombinant mAb in the presence of polyriboinosinic: polyribocytidylic acid (poly (I:C)) specifically enhanced the number of IFN-gamma producing cells and CD4+ T cell proliferation when compared to mice immunized with a mAb without receptor affinity or with the non-targeted ASP-2 protein.	Poly C	90-112	CD4 antigen	Mus musculus	192-195
26417991-2	2015	The aim of the study is to investigate the effect of polyriboinosinic:polyribocytidylic acid (poly(I:C)) in modulating toll-like receptor (TLR) 3-B-cell-activating factor belonging to the TNF family (BAFF) axis activation, which in turn promotes IgA CSR of IgAN patients and the IgAN rat model.	Poly C	70-92	toll like receptor 3	Homo sapiens	139-142
26417991-2	2015	The aim of the study is to investigate the effect of polyriboinosinic:polyribocytidylic acid (poly(I:C)) in modulating toll-like receptor (TLR) 3-B-cell-activating factor belonging to the TNF family (BAFF) axis activation, which in turn promotes IgA CSR of IgAN patients and the IgAN rat model.	Poly C	70-92	TNF superfamily member 13b	Homo sapiens	200-204
26417991-2	2015	The aim of the study is to investigate the effect of polyriboinosinic:polyribocytidylic acid (poly(I:C)) in modulating toll-like receptor (TLR) 3-B-cell-activating factor belonging to the TNF family (BAFF) axis activation, which in turn promotes IgA CSR of IgAN patients and the IgAN rat model.	Poly C	70-92	IGAN1	Homo sapiens	257-261
25345551-5	2015	RESULTS: Although flow cytometry and IHC revealed HBCs to be M2 (anti-inflammatory) macrophages, LPS and polyinosinic: polycytidylic acid [poly (I:C)] treatments markedly enhanced IL-6 secretion by HBCs, and expression of TLR-2, TLR-3, TLR-4, CD14, and MD-2 was the highest in HBCs.	Poly C	119-137	interleukin 6	Homo sapiens	180-184
25345551-5	2015	RESULTS: Although flow cytometry and IHC revealed HBCs to be M2 (anti-inflammatory) macrophages, LPS and polyinosinic: polycytidylic acid [poly (I:C)] treatments markedly enhanced IL-6 secretion by HBCs, and expression of TLR-2, TLR-3, TLR-4, CD14, and MD-2 was the highest in HBCs.	Poly C	119-137	toll like receptor 2	Homo sapiens	222-227
26417991-2	2015	The aim of the study is to investigate the effect of polyriboinosinic:polyribocytidylic acid (poly(I:C)) in modulating toll-like receptor (TLR) 3-B-cell-activating factor belonging to the TNF family (BAFF) axis activation, which in turn promotes IgA CSR of IgAN patients and the IgAN rat model.	Poly C	70-92	IGAN1	Homo sapiens	279-283
25345551-5	2015	RESULTS: Although flow cytometry and IHC revealed HBCs to be M2 (anti-inflammatory) macrophages, LPS and polyinosinic: polycytidylic acid [poly (I:C)] treatments markedly enhanced IL-6 secretion by HBCs, and expression of TLR-2, TLR-3, TLR-4, CD14, and MD-2 was the highest in HBCs.	Poly C	119-137	toll like receptor 3	Homo sapiens	229-234
25449705-9	2015	In in vitro experiments performed in coelomocytes, the expression of StmGILT mRNA was significantly up-regulated by lipopolysaccharides (LPS), inactivated bacteria or polyriboinosinic polyribocytidylic acid [poly (I:C)] challenge, suggested that the sea cucumber GILT might play critical roles in the innate immune defending against bacterial and viral infections.	Poly C	184-206	gamma-interferon-responsive lysosomal thiol protein	Cucumis sativus	72-76
25345551-5	2015	RESULTS: Although flow cytometry and IHC revealed HBCs to be M2 (anti-inflammatory) macrophages, LPS and polyinosinic: polycytidylic acid [poly (I:C)] treatments markedly enhanced IL-6 secretion by HBCs, and expression of TLR-2, TLR-3, TLR-4, CD14, and MD-2 was the highest in HBCs.	Poly C	119-137	toll like receptor 4	Homo sapiens	236-241
25345551-5	2015	RESULTS: Although flow cytometry and IHC revealed HBCs to be M2 (anti-inflammatory) macrophages, LPS and polyinosinic: polycytidylic acid [poly (I:C)] treatments markedly enhanced IL-6 secretion by HBCs, and expression of TLR-2, TLR-3, TLR-4, CD14, and MD-2 was the highest in HBCs.	Poly C	119-137	CD14 molecule	Homo sapiens	243-247
25918711-5	2015	Luciferase reporter assay and enzyme-linked immunosorbent assay (ELISA) detected the duRIG-I significantly activated NF-kappaB and induced the expression of IFN-beta when polyinosinic-polycytidylic acid (poly[I:C], synthetic double-stranded RNA) challenges chicken embryonic fibroblasts cells (DF1 cells), while the duRIG-I was inactive in the absence of poly[I:C].	Poly C	183-202	interferon omega 1	Gallus gallus	157-165
25287058-5	2014	Using RNase L-deficient, rat insulin promoter-B7.1 transgenic mice, which are more vulnerable to harmful environmental factors such as viral infection, we demonstrated that deficiency of RNase L in mice resulted in a significant delay of diabetes onset induced by polyinosinic:polycytidylic acid (poly I:C), a type of synthetic dsRNA, and streptozotocin, a drug which can artificially induce type 1-like diabetes in experimental animals.	Poly C	277-295	ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)	Mus musculus	187-194
25200153-3	2014	Twenty-four hours later, real-time quantitative PCR was applied to detect the dynamic change of IFN-beta and Mx1 mRNA expressions under the stimulation of polyinosinic polycytidylic acid (PolyI:C).	Poly C	188-195	interferon omega 1	Gallus gallus	96-104
25014275-4	2014	Interestingly, the TLR3 agonist polyinosinic:polycytidylic acid (poly(I:C)) mediated phosphorylation of NF-kappaB and extracellular stress-related kinase 1/2 (ERK1/2), which significantly decreased following PGE2 treatment.	Poly C	45-63	toll like receptor 3	Homo sapiens	19-23
25014275-4	2014	Interestingly, the TLR3 agonist polyinosinic:polycytidylic acid (poly(I:C)) mediated phosphorylation of NF-kappaB and extracellular stress-related kinase 1/2 (ERK1/2), which significantly decreased following PGE2 treatment.	Poly C	45-63	mitogen-activated protein kinase 3	Homo sapiens	159-165
25200153-3	2014	Twenty-four hours later, real-time quantitative PCR was applied to detect the dynamic change of IFN-beta and Mx1 mRNA expressions under the stimulation of polyinosinic polycytidylic acid (PolyI:C).	Poly C	188-195	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	Gallus gallus	109-112
25200153-5	2014	The expression levels of IFN-beta and Mx1 gene in cells transfected with pEGFP-C1-ALB were significantly lower than those transfected with pEGFP-C1 after 12-hour stimulation of PolyI:C (P&lt;0.05 or P&lt;0.01).	Poly C	177-184	interferon omega 1	Gallus gallus	25-33
25200153-5	2014	The expression levels of IFN-beta and Mx1 gene in cells transfected with pEGFP-C1-ALB were significantly lower than those transfected with pEGFP-C1 after 12-hour stimulation of PolyI:C (P&lt;0.05 or P&lt;0.01).	Poly C	177-184	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	Gallus gallus	38-41
25200153-5	2014	The expression levels of IFN-beta and Mx1 gene in cells transfected with pEGFP-C1-ALB were significantly lower than those transfected with pEGFP-C1 after 12-hour stimulation of PolyI:C (P&lt;0.05 or P&lt;0.01).	Poly C	177-184	albumin	Gallus gallus	82-85
24843120-2	2014	Poly(rC)-binding proteins PCBP1 and PCBP2 are multifunctional adaptor proteins that bind iron and deliver it to ferritin for storage or to prolyl and asparagyl hydroxylases to metallate the mononuclear iron center.	Poly C	0-8	poly(rC) binding protein 2	Homo sapiens	36-41
24958903-4	2014	Zebrafish IRF10 (DrIRF10) was induced by intracellular polyinosinic:polycytidylic acid in ZF4 (zebrafish embryo fibroblast-like) cells.	Poly C	68-86	interferon regulatory factor 10	Danio rerio	10-15
24958903-4	2014	Zebrafish IRF10 (DrIRF10) was induced by intracellular polyinosinic:polycytidylic acid in ZF4 (zebrafish embryo fibroblast-like) cells.	Poly C	68-86	interferon regulatory factor 10	Danio rerio	17-24
24958903-5	2014	DrIRF10 inhibited the activation of zebrafish IFN1 (DrIFN1) and DrIFN3 promoters in epithelioma papulosum cyprinid cells in the presence or absence of polyinosinic:polycytidylic acid stimulation through direct interaction with the IFN promoters, and this inhibition was also shown to block IFN signaling.	Poly C	164-182	interferon regulatory factor 10	Danio rerio	0-7
24843120-2	2014	Poly(rC)-binding proteins PCBP1 and PCBP2 are multifunctional adaptor proteins that bind iron and deliver it to ferritin for storage or to prolyl and asparagyl hydroxylases to metallate the mononuclear iron center.	Poly C	0-8	poly(rC) binding protein 1	Homo sapiens	26-31
24026233-0	2013	Novel function of the poly(c)-binding protein alpha-CP2 as a transcriptional activator that binds to single-stranded DNA sequences.	Poly C	22-28	poly(rC) binding protein 2	Mus musculus	46-55
24706959-0	2014	Dramatic differences in the response of macrophages from B2 and B19 MHC-defined haplotypes to interferon gamma and polyinosinic:polycytidylic acid stimulation.	Poly C	128-146	immunoglobulin kappa variable 5-2	Homo sapiens	57-65
24447537-8	2014	Mechanistic studies show that PELP1 binds RNA with a preference to poly-C, co-localizes with the splicing factor SC35 at nuclear speckles, and participates in alternative splicing.	Poly C	67-73	proline, glutamate and leucine rich protein 1	Homo sapiens	30-35
24056124-5	2013	Tunicamycin also inhibited the expression of inflammatory molecule mRNAs induced by stimulation of TLR2 (with lipoteichoic acid) or TLR3 (with polyinosinic:polycytidylic acid), which do not require myeloid differentiation protein-2 (MD2) for their activation.	Poly C	156-174	toll-like receptor 3	Mus musculus	132-136
24035358-5	2013	It was found that microRNA-301a (miR-301a) was up-regulated by the ligands of TLR3 and TLR4, LPS and polyinosinic acid:polycytidylic acid poly(I:C).	Poly C	119-137	microRNA 301a	Homo sapiens	18-31
24035358-5	2013	It was found that microRNA-301a (miR-301a) was up-regulated by the ligands of TLR3 and TLR4, LPS and polyinosinic acid:polycytidylic acid poly(I:C).	Poly C	119-137	microRNA 301a	Homo sapiens	33-41
24035358-5	2013	It was found that microRNA-301a (miR-301a) was up-regulated by the ligands of TLR3 and TLR4, LPS and polyinosinic acid:polycytidylic acid poly(I:C).	Poly C	119-137	toll like receptor 3	Homo sapiens	78-82
24035358-5	2013	It was found that microRNA-301a (miR-301a) was up-regulated by the ligands of TLR3 and TLR4, LPS and polyinosinic acid:polycytidylic acid poly(I:C).	Poly C	119-137	toll like receptor 4	Homo sapiens	87-91
24113362-6	2014	The expression of interferon (IFN)-beta was induced by the addition of polyinosinic:polycytidylic acid [poly(I:C)] in TS cells, but not ES cells, although TLR-3 was expressed at the same level in both cell types.	Poly C	84-102	interferon beta 1, fibroblast	Mus musculus	18-39
24056979-6	2013	However, TLR3 and interferon signaling pathways were decreased to a greater extent, and assessment of the effects of SMD on polyinosinic polycytidylic acid-induced cytokine and chemokine production revealed that these responses mediated by TLR3 were indeed sensitive to the effects of SMD, with inhibition occurring at lower dosages than required to inhibit responses to other immunological stimuli tested in our previous studies.	Poly C	137-155	toll-like receptor 3	Mus musculus	240-244
23871888-10	2013	Treatment with CVB3 and polyinosinic:polycytidylic acid led to higher IFNbeta expression in PAR2ko than in wt fibroblasts and reduced virus replication in PAR2ko fibroblasts was abrogated by neutralizing IFNbeta antibody.	Poly C	37-55	interferon beta 1	Homo sapiens	70-77
23871888-10	2013	Treatment with CVB3 and polyinosinic:polycytidylic acid led to higher IFNbeta expression in PAR2ko than in wt fibroblasts and reduced virus replication in PAR2ko fibroblasts was abrogated by neutralizing IFNbeta antibody.	Poly C	37-55	interferon beta 1	Homo sapiens	204-211
24026233-1	2013	alpha-complex protein 2 (alpha-CP2) is known as an RNA-binding protein that interacts in a sequence-specific manner with single-stranded polycytosine [poly(C)].	Poly C	151-158	poly(rC) binding protein 2	Mus musculus	0-23
24026233-1	2013	alpha-complex protein 2 (alpha-CP2) is known as an RNA-binding protein that interacts in a sequence-specific manner with single-stranded polycytosine [poly(C)].	Poly C	151-158	poly(rC) binding protein 2	Mus musculus	25-34
24026233-8	2013	Furthermore, plasmids expressing alpha-CP2 activated the expression of a luciferase reporter when co-transfected with a single-stranded (pGL-SS) construct containing a poly(C) sequence.	Poly C	168-175	poly(rC) binding protein 2	Mus musculus	33-42
24026233-9	2013	To our knowledge, this study demonstrates for the first time that alpha-CP2 functions as a transcriptional activator by binding to a single-stranded poly(C) sequence.	Poly C	149-156	poly(rC) binding protein 2	Mus musculus	66-75
23887873-5	2013	Tlr4(-/-) mice primed with TLR3 agonist polyinosinic:polycytidylic acid [poly(I:C)] to induce pro-caspase-11 expression were as susceptible as wild-type mice were to sepsis induced by E. coli LPS.	Poly C	53-71	toll-like receptor 4	Mus musculus	0-4
23887873-5	2013	Tlr4(-/-) mice primed with TLR3 agonist polyinosinic:polycytidylic acid [poly(I:C)] to induce pro-caspase-11 expression were as susceptible as wild-type mice were to sepsis induced by E. coli LPS.	Poly C	53-71	toll-like receptor 3	Mus musculus	27-31
23742880-7	2013	Furthermore, the polypeptide micelles could simultaneously encapsulate OVA and polyriboinosinic: polyribocytidylic acid (PIC), a TLR3 agonist, to synergistically augment tumor specific cytotoxic-T-lymphocyte (CTL) response.	Poly C	97-119	toll like receptor 3	Homo sapiens	129-133
23742880-7	2013	Furthermore, the polypeptide micelles could simultaneously encapsulate OVA and polyriboinosinic: polyribocytidylic acid (PIC), a TLR3 agonist, to synergistically augment tumor specific cytotoxic-T-lymphocyte (CTL) response.	Poly C	121-124	toll like receptor 3	Homo sapiens	129-133
23720812-5	2013	Treatment with LPS preferentially stimulated IL-17 production, whereas CpG oligodeoxynucleotide and polyinosinic:polycytidylic acid primarily stimulated Th1 cells.	Poly C	113-131	negative elongation factor complex member C/D, Th1l	Mus musculus	153-156
23541683-3	2013	Activation of TLR3 by polyinosinic:polycytidylic acid [poly(I:C)] treatment is effective to suppress cell migration and invasion and to decrease organized assembly of F-actin and filopodia formation, in TLR3-expressing SK-N-AS cells, which could be reversed by TLR3-targeting siRNA treatment.	Poly C	35-53	toll like receptor 3	Homo sapiens	14-18
23541683-3	2013	Activation of TLR3 by polyinosinic:polycytidylic acid [poly(I:C)] treatment is effective to suppress cell migration and invasion and to decrease organized assembly of F-actin and filopodia formation, in TLR3-expressing SK-N-AS cells, which could be reversed by TLR3-targeting siRNA treatment.	Poly C	35-53	toll like receptor 3	Homo sapiens	203-207
23541683-3	2013	Activation of TLR3 by polyinosinic:polycytidylic acid [poly(I:C)] treatment is effective to suppress cell migration and invasion and to decrease organized assembly of F-actin and filopodia formation, in TLR3-expressing SK-N-AS cells, which could be reversed by TLR3-targeting siRNA treatment.	Poly C	35-53	toll like receptor 3	Homo sapiens	203-207
23941132-9	2013	In NHBE cells, mRNA expression of CEACAM1 isoforms CEACAM1-4L, CEACAM1-4S, CEACAM1-3L and CEACAM1-3S were up-regulated by interferons alpha, beta and gamma, as well as the TLR3 agonist polyinosinic:polycytidylic acid (poly I:C).	Poly C	198-216	CEA cell adhesion molecule 1	Homo sapiens	34-41
23941132-9	2013	In NHBE cells, mRNA expression of CEACAM1 isoforms CEACAM1-4L, CEACAM1-4S, CEACAM1-3L and CEACAM1-3S were up-regulated by interferons alpha, beta and gamma, as well as the TLR3 agonist polyinosinic:polycytidylic acid (poly I:C).	Poly C	198-216	CEA cell adhesion molecule 1	Homo sapiens	51-58
23941132-9	2013	In NHBE cells, mRNA expression of CEACAM1 isoforms CEACAM1-4L, CEACAM1-4S, CEACAM1-3L and CEACAM1-3S were up-regulated by interferons alpha, beta and gamma, as well as the TLR3 agonist polyinosinic:polycytidylic acid (poly I:C).	Poly C	198-216	CEA cell adhesion molecule 1	Homo sapiens	51-58
23941132-9	2013	In NHBE cells, mRNA expression of CEACAM1 isoforms CEACAM1-4L, CEACAM1-4S, CEACAM1-3L and CEACAM1-3S were up-regulated by interferons alpha, beta and gamma, as well as the TLR3 agonist polyinosinic:polycytidylic acid (poly I:C).	Poly C	198-216	CEA cell adhesion molecule 1	Homo sapiens	51-58
23941132-9	2013	In NHBE cells, mRNA expression of CEACAM1 isoforms CEACAM1-4L, CEACAM1-4S, CEACAM1-3L and CEACAM1-3S were up-regulated by interferons alpha, beta and gamma, as well as the TLR3 agonist polyinosinic:polycytidylic acid (poly I:C).	Poly C	198-216	CEA cell adhesion molecule 1	Homo sapiens	51-58
23739343-7	2013	A Toll-like receptor (TLR)3 agonist and viral mimetic polyinosinic:polycytidylic acid evoked a robust fever in CB1(-/-) mice, suggesting TLR3-mediated responses are functional.	Poly C	67-85	cannabinoid receptor 1 (brain)	Mus musculus	111-114
23739343-7	2013	A Toll-like receptor (TLR)3 agonist and viral mimetic polyinosinic:polycytidylic acid evoked a robust fever in CB1(-/-) mice, suggesting TLR3-mediated responses are functional.	Poly C	67-85	toll-like receptor 3	Mus musculus	137-141
23586396-10	2013	This was accompanied by a parallel reduction in the poly I:C-stimulated elevation in plasma levels of IL-1beta and PGE2.	Poly C	52-60	interleukin-1 beta	Oryctolagus cuniculus	102-110
23178261-10	2013	TGF-beta1b expression was also increased by polyinosinic:polycytidylic acid (poly(I:C)) and/or lipopolysaccharide (LPS) stimulation in three different trout cell lines studied.	Poly C	57-75	transforming growth factor, beta 1a	Oncorhynchus mykiss	0-10
23677472-7	2013	Moreover, although both Wnts suppress proinflammatory responses to bacterial endotoxin and to TLR1/2, TLR7, and TLR9 ligands, Wnt5A, but not Wnt3A, inhibits IL-6 production in response to the viral mimic, polyinosinic:polycytidylic acid.	Poly C	218-236	wingless-type MMTV integration site family, member 5A	Mus musculus	126-131
23585479-1	2013	PCBP2 is a member of the poly(C)-binding protein (PCBP) family, which plays an important role in posttranscriptional and translational regulation by interacting with single-stranded poly(C) motifs in target mRNAs.	Poly C	25-32	poly(rC) binding protein 2	Homo sapiens	0-5
23153456-7	2013	Using the viral mimic polyinosinic:polycytidylic acid and the IFNalpha/beta antagonist B18R we furthermore demonstrate the capability of endogenous IFN to promote IL-22-induced STAT1 activation and expression of CXCL10.	Poly C	35-53	interleukin 22	Homo sapiens	163-168
23153456-7	2013	Using the viral mimic polyinosinic:polycytidylic acid and the IFNalpha/beta antagonist B18R we furthermore demonstrate the capability of endogenous IFN to promote IL-22-induced STAT1 activation and expression of CXCL10.	Poly C	35-53	signal transducer and activator of transcription 1	Homo sapiens	177-182
23153456-7	2013	Using the viral mimic polyinosinic:polycytidylic acid and the IFNalpha/beta antagonist B18R we furthermore demonstrate the capability of endogenous IFN to promote IL-22-induced STAT1 activation and expression of CXCL10.	Poly C	35-53	C-X-C motif chemokine ligand 10	Homo sapiens	212-218
23716670-3	2013	Here we show that TLR3 activation by polyinosinic:polycytidylic acid induces up-regulation of microRNA-29b, -29c, -148b, and -152 in tumor-derived cell lines and primary tumors.	Poly C	50-68	toll like receptor 3	Homo sapiens	18-22
23716670-5	2013	In DU145 and TRAMP-C1 prostate and MDA-MB-231 breast cancer cells, we demonstrated that polyinosinic:polycytidylic acid-mediated activation of TLR3 induces microRNAs targeting DNA methyltransferases, leading to demethylation and reexpression of the oncosuppressor retinoic acid receptor beta (RARbeta).	Poly C	101-119	toll like receptor 3	Homo sapiens	143-147
23716670-5	2013	In DU145 and TRAMP-C1 prostate and MDA-MB-231 breast cancer cells, we demonstrated that polyinosinic:polycytidylic acid-mediated activation of TLR3 induces microRNAs targeting DNA methyltransferases, leading to demethylation and reexpression of the oncosuppressor retinoic acid receptor beta (RARbeta).	Poly C	101-119	retinoic acid receptor beta	Homo sapiens	264-291
23716670-5	2013	In DU145 and TRAMP-C1 prostate and MDA-MB-231 breast cancer cells, we demonstrated that polyinosinic:polycytidylic acid-mediated activation of TLR3 induces microRNAs targeting DNA methyltransferases, leading to demethylation and reexpression of the oncosuppressor retinoic acid receptor beta (RARbeta).	Poly C	101-119	retinoic acid receptor beta	Homo sapiens	293-300
23387336-4	2013	METHODS: TLR3 activation via polyinosinic acid/polycytidylic acid (Poly I:C) was investigated in primary porcine RPE cells, focussing on cell death and vascular endothelial growth factor (VEGF) secretion.	Poly C	47-65	toll like receptor 3	Homo sapiens	9-13
22797253-2	2012	All-trans retinoic acid (ATRA) and polyinosinic:polycytidylic acid (polyI:C) are strong inducers of toll-like receptor 3 (TLR3) and MDA5 expression, and polyI:C-induced TLR3 and MDA5 signaling specifically causes cell death in melanoma cells in vitro.	Poly C	48-66	toll like receptor 3	Homo sapiens	100-120
23673618-6	2013	Like polyriboinosinic:polyribocytidylic acid, a synthetic double-stranded RNA, these RNAs are internalized into cells via raftlin-mediated endocytosis and colocalized with TLR3.	Poly C	22-44	raftlin, lipid raft linker 1	Homo sapiens	122-129
23673618-6	2013	Like polyriboinosinic:polyribocytidylic acid, a synthetic double-stranded RNA, these RNAs are internalized into cells via raftlin-mediated endocytosis and colocalized with TLR3.	Poly C	22-44	toll like receptor 3	Homo sapiens	172-176
23087404-3	2012	We found that overexpression of Ndfip1 severely impaired MAVS and Sendai virus-mediated activation of IFN-stimulated response element, NF-kappaB, IFN-beta promoter, and polyinosinic-polycytidylic acid or influenza virus RNA-stimulated IRF-3 phosphorylation, as well as the transcription of IFN-beta.	Poly C	181-200	Nedd4 family interacting protein 1	Homo sapiens	32-38
22914602-4	2012	OBJECTIVE: To study the effects and signaling pathways of formoterol and salmeterol on polyriboinosinic polyribocytidylic acid (poly I:C)-induced IP-10 expression in BEAS-2B cells.	Poly C	128-136	C-X-C motif chemokine ligand 10	Homo sapiens	146-151
22732733-6	2013	The TfPLL conjugate protected TLR3 ligand polyinosinic:polycytidylic acid [poly(I:C)] from RNase degradation and enhanced the uptake of poly(I:C) in HeLa cells.	Poly C	55-73	toll like receptor 3	Homo sapiens	30-34
22797253-2	2012	All-trans retinoic acid (ATRA) and polyinosinic:polycytidylic acid (polyI:C) are strong inducers of toll-like receptor 3 (TLR3) and MDA5 expression, and polyI:C-induced TLR3 and MDA5 signaling specifically causes cell death in melanoma cells in vitro.	Poly C	48-66	toll like receptor 3	Homo sapiens	122-126
22797253-2	2012	All-trans retinoic acid (ATRA) and polyinosinic:polycytidylic acid (polyI:C) are strong inducers of toll-like receptor 3 (TLR3) and MDA5 expression, and polyI:C-induced TLR3 and MDA5 signaling specifically causes cell death in melanoma cells in vitro.	Poly C	48-66	interferon induced with helicase C domain 1	Homo sapiens	132-136
22797253-2	2012	All-trans retinoic acid (ATRA) and polyinosinic:polycytidylic acid (polyI:C) are strong inducers of toll-like receptor 3 (TLR3) and MDA5 expression, and polyI:C-induced TLR3 and MDA5 signaling specifically causes cell death in melanoma cells in vitro.	Poly C	48-66	toll like receptor 3	Homo sapiens	169-173
22797253-2	2012	All-trans retinoic acid (ATRA) and polyinosinic:polycytidylic acid (polyI:C) are strong inducers of toll-like receptor 3 (TLR3) and MDA5 expression, and polyI:C-induced TLR3 and MDA5 signaling specifically causes cell death in melanoma cells in vitro.	Poly C	48-66	interferon induced with helicase C domain 1	Homo sapiens	178-182
22951310-2	2012	In the present study, we have analyzed the interaction of Nsp1beta of Chinese highly pathogenic PRRSV (HP-PRRSV) with cellular poly(C)-binding 2 (PCBP2) by means of the yeast two-hybrid screening in a pulmonary alveolar macrophages (PAMs) cDNA library and co-immunoprecipitation (Co-IP) assay.	Poly C	127-134	poly(rC) binding protein 2	Homo sapiens	146-151
22466005-3	2012	Based on this knowledge, this study aimed to define the effects of the TLR3 ligand polyriboinosinic:polyribocytidylic acid (poly(I:C)) on the expression of adhesion molecules and macrophage colony-stimulating factor (M-CSF) on resident glomerular cells.	Poly C	100-122	toll like receptor 3	Homo sapiens	71-75
22634298-3	2012	Although polyriboinosinic: polyribocytidylic acid (PIC), a TLR3 agonist, has been reported as a promising adjuvant for cancer vaccines, its immunopotency may be limited by insufficient cellular penetration.	Poly C	51-54	toll-like receptor 3	Mus musculus	59-63
22634298-9	2012	Taking together, the complex of PIC and DOTAP liposomes enhanced PIC uptake and consequential TLR3 signaling in BMDCs, which in turn promoted DC maturation and type I IFN production, thereby augmenting the antitumor effect of cancer vaccines.	Poly C	32-35	toll-like receptor 3	Mus musculus	94-98
22466005-3	2012	Based on this knowledge, this study aimed to define the effects of the TLR3 ligand polyriboinosinic:polyribocytidylic acid (poly(I:C)) on the expression of adhesion molecules and macrophage colony-stimulating factor (M-CSF) on resident glomerular cells.	Poly C	100-122	colony stimulating factor 1	Homo sapiens	179-215
22466005-3	2012	Based on this knowledge, this study aimed to define the effects of the TLR3 ligand polyriboinosinic:polyribocytidylic acid (poly(I:C)) on the expression of adhesion molecules and macrophage colony-stimulating factor (M-CSF) on resident glomerular cells.	Poly C	100-122	colony stimulating factor 1	Homo sapiens	217-222
22521865-6	2012	Electrophoretic mobility shift assays demonstrated that the recombinant PCBP3 is capable of binding to both double- and single-strand poly(C) sequences.	Poly C	134-141	poly(rC) binding protein 3	Homo sapiens	72-77
22698190-1	2012	BACKGROUND: Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid: polycytidylic acid [Poly (I:C)], are recognized by toll-like receptor 3 (TLR3) and induce interferon (IFN)-beta in many cell types.	Poly C	74-92	toll like receptor 3	Homo sapiens	125-145
22698190-1	2012	BACKGROUND: Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid: polycytidylic acid [Poly (I:C)], are recognized by toll-like receptor 3 (TLR3) and induce interferon (IFN)-beta in many cell types.	Poly C	74-92	toll like receptor 3	Homo sapiens	147-151
22698190-1	2012	BACKGROUND: Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid: polycytidylic acid [Poly (I:C)], are recognized by toll-like receptor 3 (TLR3) and induce interferon (IFN)-beta in many cell types.	Poly C	74-92	interferon beta 1	Homo sapiens	164-185
22681877-3	2012	Pregnant rats were treated with the double-stranded RNA polyinosinic:polycytidylic acid (poly(I:C); 10 mg/kg) which mimics immune activation occurring after activation of Toll-like receptors-3 (TLR3) by viral infection.	Poly C	69-87	toll-like receptor 3	Rattus norvegicus	171-192
22521865-7	2012	Furthermore, plasmids expressing PCBP3 repressed the expression of luciferase reporters when cotransfected with single-strand (pGL-SS) and double-strand (pGL-DS) constructs containing poly(C) sequences in their promoters.	Poly C	184-191	poly(rC) binding protein 3	Homo sapiens	33-38
22681877-3	2012	Pregnant rats were treated with the double-stranded RNA polyinosinic:polycytidylic acid (poly(I:C); 10 mg/kg) which mimics immune activation occurring after activation of Toll-like receptors-3 (TLR3) by viral infection.	Poly C	69-87	toll-like receptor 3	Rattus norvegicus	194-198
22521865-8	2012	This study demonstrates for the first time that PCBP3 can function as a repressor dependent on binding to single-strand and double-stranded poly(C) sequences.	Poly C	140-147	poly(rC) binding protein 3	Homo sapiens	48-53
21799119-3	2012	We recently showed that a low-dose administration of polyinosinic polycytidylic acid (poly IC), a mimetic of viral dsRNA, during allergen sensitization augments airway eosinophilia and hyperresponsiveness in mice via enhanced production of IL-13 from T cells.	Poly C	86-93	interleukin 13	Mus musculus	240-245
21799119-9	2012	Serum IL-6 was prominently higher in the mice treated with poly IC/d-GalN than in that with poly IC alone or d-GalN alone.	Poly C	59-66	interleukin 6	Mus musculus	6-10
22497726-6	2012	Activation of TLR4 and TLR3 signaling through LPS and polyinosinic:polycytidylic acid [poly(I:C)] treatments resulted in rapid down-regulation of HFE protein [encoded by the hemochromatosis gene (Hfe)] and ferroportin [encoded by solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1)] expression in the spleen, independent of MyD88 or TRIF signaling and proinflammatory cytokine production.	Poly C	67-85	toll-like receptor 4	Mus musculus	14-18
22497726-6	2012	Activation of TLR4 and TLR3 signaling through LPS and polyinosinic:polycytidylic acid [poly(I:C)] treatments resulted in rapid down-regulation of HFE protein [encoded by the hemochromatosis gene (Hfe)] and ferroportin [encoded by solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1)] expression in the spleen, independent of MyD88 or TRIF signaling and proinflammatory cytokine production.	Poly C	67-85	toll-like receptor 3	Mus musculus	23-27
22497726-6	2012	Activation of TLR4 and TLR3 signaling through LPS and polyinosinic:polycytidylic acid [poly(I:C)] treatments resulted in rapid down-regulation of HFE protein [encoded by the hemochromatosis gene (Hfe)] and ferroportin [encoded by solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1)] expression in the spleen, independent of MyD88 or TRIF signaling and proinflammatory cytokine production.	Poly C	67-85	homeostatic iron regulator	Mus musculus	146-149
22497726-6	2012	Activation of TLR4 and TLR3 signaling through LPS and polyinosinic:polycytidylic acid [poly(I:C)] treatments resulted in rapid down-regulation of HFE protein [encoded by the hemochromatosis gene (Hfe)] and ferroportin [encoded by solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1)] expression in the spleen, independent of MyD88 or TRIF signaling and proinflammatory cytokine production.	Poly C	67-85	homeostatic iron regulator	Mus musculus	196-199
22497726-6	2012	Activation of TLR4 and TLR3 signaling through LPS and polyinosinic:polycytidylic acid [poly(I:C)] treatments resulted in rapid down-regulation of HFE protein [encoded by the hemochromatosis gene (Hfe)] and ferroportin [encoded by solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1)] expression in the spleen, independent of MyD88 or TRIF signaling and proinflammatory cytokine production.	Poly C	67-85	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	295-302
22497726-6	2012	Activation of TLR4 and TLR3 signaling through LPS and polyinosinic:polycytidylic acid [poly(I:C)] treatments resulted in rapid down-regulation of HFE protein [encoded by the hemochromatosis gene (Hfe)] and ferroportin [encoded by solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1)] expression in the spleen, independent of MyD88 or TRIF signaling and proinflammatory cytokine production.	Poly C	67-85	myeloid differentiation primary response gene 88	Mus musculus	346-351
21799119-9	2012	Serum IL-6 was prominently higher in the mice treated with poly IC/d-GalN than in that with poly IC alone or d-GalN alone.	Poly C	59-66	galanin and GMAP prepropeptide	Mus musculus	69-73
21799119-9	2012	Serum IL-6 was prominently higher in the mice treated with poly IC/d-GalN than in that with poly IC alone or d-GalN alone.	Poly C	59-66	galanin and GMAP prepropeptide	Mus musculus	111-115
21929369-4	2012	The TLR7 ligand poly-C inhibited low-path influenza A growth in the chicken macrophage cell line HD-11 more effectively than poly(I:C), which acts via TLR3.	Poly C	16-22	toll like receptor 7	Gallus gallus	4-8
22315398-0	2012	Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells.	Poly C	92-110	protein phosphatase 1 regulatory subunit 15A	Homo sapiens	30-38
22315398-0	2012	Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells.	Poly C	92-110	protein phosphatase 1 regulatory subunit 15A	Homo sapiens	39-45
22315398-2	2012	Here we show that in response to polyriboinosinic:polyribocytidylic acid (pI:C), DCs mount a specific integrated stress response during which the transcription factor ATF4 and the growth arrest and DNA damage-inducible protein 34 (GADD34/Ppp1r15a), a phosphatase 1 (PP1) cofactor, are expressed.	Poly C	50-72	activating transcription factor 4	Homo sapiens	167-171
22315398-2	2012	Here we show that in response to polyriboinosinic:polyribocytidylic acid (pI:C), DCs mount a specific integrated stress response during which the transcription factor ATF4 and the growth arrest and DNA damage-inducible protein 34 (GADD34/Ppp1r15a), a phosphatase 1 (PP1) cofactor, are expressed.	Poly C	50-72	protein phosphatase 1 regulatory subunit 15A	Homo sapiens	231-237
22315398-2	2012	Here we show that in response to polyriboinosinic:polyribocytidylic acid (pI:C), DCs mount a specific integrated stress response during which the transcription factor ATF4 and the growth arrest and DNA damage-inducible protein 34 (GADD34/Ppp1r15a), a phosphatase 1 (PP1) cofactor, are expressed.	Poly C	50-72	protein phosphatase 1 regulatory subunit 15A	Homo sapiens	238-246
21778412-5	2012	The potential consequences of diminished type I IFN signaling were demonstrated in a murine model of P. aeruginosa pneumonia, pretreatment with polyinosinic:polycytidylic acid significantly enhanced bacterial clearance and correlated with increased numbers of mature CD11c(+)/CD86(+) dendritic cells (DCs) in the lung.	Poly C	157-175	integrin subunit alpha X	Homo sapiens	267-272
22497726-6	2012	Activation of TLR4 and TLR3 signaling through LPS and polyinosinic:polycytidylic acid [poly(I:C)] treatments resulted in rapid down-regulation of HFE protein [encoded by the hemochromatosis gene (Hfe)] and ferroportin [encoded by solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1)] expression in the spleen, independent of MyD88 or TRIF signaling and proinflammatory cytokine production.	Poly C	67-85	toll-like receptor adaptor molecule 2	Mus musculus	355-359
22503273-3	2012	This study found that purified DSC extensively shed BAFF-R and that polyinosinic:polycytidylic acid (poly(I:C); a synthetic toll-like receptor (TLR) 3 agonist) dramatically up-regulated BAFF-R secretion, suggesting that release of these soluble proteins was an inherent property of DSC and its induction might have relevance to TLR-3-mediated signal transduction.	Poly C	81-99	toll like receptor 3	Homo sapiens	144-147
22503273-3	2012	This study found that purified DSC extensively shed BAFF-R and that polyinosinic:polycytidylic acid (poly(I:C); a synthetic toll-like receptor (TLR) 3 agonist) dramatically up-regulated BAFF-R secretion, suggesting that release of these soluble proteins was an inherent property of DSC and its induction might have relevance to TLR-3-mediated signal transduction.	Poly C	81-99	TNF receptor superfamily member 13C	Homo sapiens	186-192
22503273-3	2012	This study found that purified DSC extensively shed BAFF-R and that polyinosinic:polycytidylic acid (poly(I:C); a synthetic toll-like receptor (TLR) 3 agonist) dramatically up-regulated BAFF-R secretion, suggesting that release of these soluble proteins was an inherent property of DSC and its induction might have relevance to TLR-3-mediated signal transduction.	Poly C	81-99	toll like receptor 3	Homo sapiens	328-333
22198151-0	2012	A synthetic double-stranded RNA, poly I:C, induces a rapid apoptosis of human CD34(+) cells.	Poly C	33-41	CD34 molecule	Homo sapiens	78-82
22198151-4	2012	Here we show that polyinosinic polycytidylic acid (poly I:C)-mediated very rapid apoptosis occurs within 1 hour in CD34(+) cells in a dose-dependent manner.	Poly C	51-59	CD34 molecule	Homo sapiens	115-119
22198151-6	2012	Poly I:C-LMW/LyoVec, a complex between low molecular-weight poly I:C and the transfection reagent LyoVec, which signals only through RIG-I/MDA-5, induces apoptosis of CD34(+) cells.	Poly C	60-68	DExD/H-box helicase 58	Homo sapiens	133-138
22198151-6	2012	Poly I:C-LMW/LyoVec, a complex between low molecular-weight poly I:C and the transfection reagent LyoVec, which signals only through RIG-I/MDA-5, induces apoptosis of CD34(+) cells.	Poly C	60-68	interferon induced with helicase C domain 1	Homo sapiens	139-144
22198151-6	2012	Poly I:C-LMW/LyoVec, a complex between low molecular-weight poly I:C and the transfection reagent LyoVec, which signals only through RIG-I/MDA-5, induces apoptosis of CD34(+) cells.	Poly C	60-68	CD34 molecule	Homo sapiens	167-171
22198151-8	2012	These results suggest that RIG-I/MDA-5, but not TLR3, signaling triggers poly I:C-induced rapid apoptosis of human CD34(+) cells, which will provide an insight into the mechanisms of dsRNA virus-mediated hematopoietic disorders.	Poly C	73-81	DExD/H-box helicase 58	Homo sapiens	27-32
22198151-8	2012	These results suggest that RIG-I/MDA-5, but not TLR3, signaling triggers poly I:C-induced rapid apoptosis of human CD34(+) cells, which will provide an insight into the mechanisms of dsRNA virus-mediated hematopoietic disorders.	Poly C	73-81	interferon induced with helicase C domain 1	Homo sapiens	33-38
22198151-8	2012	These results suggest that RIG-I/MDA-5, but not TLR3, signaling triggers poly I:C-induced rapid apoptosis of human CD34(+) cells, which will provide an insight into the mechanisms of dsRNA virus-mediated hematopoietic disorders.	Poly C	73-81	CD34 molecule	Homo sapiens	115-119
21929369-4	2012	The TLR7 ligand poly-C inhibited low-path influenza A growth in the chicken macrophage cell line HD-11 more effectively than poly(I:C), which acts via TLR3.	Poly C	16-22	toll like receptor 3	Gallus gallus	151-155
21327636-2	2011	In the present study, we found that Polyinosinic:Polycytidylic Acid [Poly(I:C)] and CpG oligodeoxynucleotide 1826 [CpG], agonists for TLR 3 and 9, respectively, potently activated adoptively transferred T cells against a murine model of established melanoma.	Poly C	49-67	toll-like receptor 3	Mus musculus	134-145
21968540-0	2012	Interferon-beta, but not tumor necrosis factor-alpha, production in response to poly I:C is maintained despite exhaustive exercise in mice.	Poly C	80-88	interferon beta 1, fibroblast	Mus musculus	0-15
21968540-4	2012	Although TNF-alpha in response to poly I:C was significantly inhibited by exhaustive exercise, IFN-beta was no different in both groups.	Poly C	34-42	tumor necrosis factor	Mus musculus	9-18
21968540-5	2012	In in-vitro experiments, catecholamines inhibited poly I:C-induced TNF-alpha, but not IFN-beta, production in macrophages.	Poly C	50-58	tumor necrosis factor	Mus musculus	67-76
21968540-6	2012	These results suggest that anti-virus cytokine IFN-beta in response to poly I:C might be maintained despite severe stressful exercise.	Poly C	71-79	interferon beta 1, fibroblast	Mus musculus	47-55
21996340-0	2011	Polyinosinic:polycytidylic acid induces protein kinase D-dependent disassembly of apical junctions and barrier dysfunction in airway epithelial cells.	Poly C	13-31	protein kinase D1	Homo sapiens	40-56
21563279-3	2011	We show that TLR3 triggering by polyinosinic:polycytidylic acid dramatically amplifies, in a more significant manner than TLR4 triggering by lipopolysaccharide, the antiapoptotic effects that resting BM-MSC constitutively exert on PMN under coculture conditions, preserving a significant fraction of viable and functional PMN up to 72 hours.	Poly C	45-63	toll like receptor 3	Homo sapiens	13-17
21278304-5	2011	METHODS: We compared the effects of transgenic VEGF(165) in mice treated with viral pathogen-associated molecular pattern polyinosinic:polycytidylic acid [poly(I:C)], mice treated with live virus, and control mice.	Poly C	135-153	vascular endothelial growth factor A	Mus musculus	47-51
22496660-4	2012	Recombinant NS5 proteins of West Nile virus and Dengue virus (serotype 4; DENV-4) specifically methylates polyA, but not polyG, polyC, or polyU, indicating that the methylation occurs at adenosine residue.	Poly C	128-133	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	12-15
22065573-7	2011	We demonstrate that the TLR3 ligand polyriboinosinic:polyribocytidylic acid (poly(I:C)) induces expression and nuclear translocation of YinYang1 where it interacts with the IFN-beta promoter and inhibits the binding of IRF7 to the latter.	Poly C	53-75	toll like receptor 3	Homo sapiens	24-28
22065573-7	2011	We demonstrate that the TLR3 ligand polyriboinosinic:polyribocytidylic acid (poly(I:C)) induces expression and nuclear translocation of YinYang1 where it interacts with the IFN-beta promoter and inhibits the binding of IRF7 to the latter.	Poly C	53-75	YY1 transcription factor	Homo sapiens	136-144
22065573-7	2011	We demonstrate that the TLR3 ligand polyriboinosinic:polyribocytidylic acid (poly(I:C)) induces expression and nuclear translocation of YinYang1 where it interacts with the IFN-beta promoter and inhibits the binding of IRF7 to the latter.	Poly C	53-75	interferon beta 1	Homo sapiens	173-181
22065573-7	2011	We demonstrate that the TLR3 ligand polyriboinosinic:polyribocytidylic acid (poly(I:C)) induces expression and nuclear translocation of YinYang1 where it interacts with the IFN-beta promoter and inhibits the binding of IRF7 to the latter.	Poly C	53-75	interferon regulatory factor 7	Homo sapiens	219-223
21976648-4	2011	To further our understanding of the role of the viral nsp1 in these processes, using nsp1beta, a proteolytically processed functional product of nsp1 as bait, we have identified the cellular poly(C)-binding proteins 1 and 2 (PCBP1 and PCBP2) as two of its interaction partners.	Poly C	191-198	SH2 domain containing 3A	Homo sapiens	54-58
21976648-4	2011	To further our understanding of the role of the viral nsp1 in these processes, using nsp1beta, a proteolytically processed functional product of nsp1 as bait, we have identified the cellular poly(C)-binding proteins 1 and 2 (PCBP1 and PCBP2) as two of its interaction partners.	Poly C	191-198	SH2 domain containing 3A	Homo sapiens	85-89
21976648-4	2011	To further our understanding of the role of the viral nsp1 in these processes, using nsp1beta, a proteolytically processed functional product of nsp1 as bait, we have identified the cellular poly(C)-binding proteins 1 and 2 (PCBP1 and PCBP2) as two of its interaction partners.	Poly C	191-198	poly(rC) binding protein 1	Homo sapiens	225-230
21976648-4	2011	To further our understanding of the role of the viral nsp1 in these processes, using nsp1beta, a proteolytically processed functional product of nsp1 as bait, we have identified the cellular poly(C)-binding proteins 1 and 2 (PCBP1 and PCBP2) as two of its interaction partners.	Poly C	191-198	poly(rC) binding protein 2	Homo sapiens	235-240
21964025-5	2011	Costimulation of primary human fibroblasts with IL-17 greatly enhanced respiratory syncytial virus-induced or synthetic dsRNA-based viral mimic polyinosinic:polycytidylic acid-induced expression of proinflammatory genes without affecting expression of IFN-beta-stimulated or IFN-stimulated genes.	Poly C	157-175	interleukin 17A	Homo sapiens	48-53
21540291-5	2011	Both TLR3 and TLR4 can be activated by their agonists (polyinosinic:polycytidylic acid and lipopolysaccharide) in Leydig cells and subsequently induce the production of inflammatory factors, such as IL-1beta, IL-6, TNF-alpha, and type 1 interferons (IFN) (IFN-alpha and IFN-beta).	Poly C	68-86	toll-like receptor 3	Mus musculus	5-9
21540291-5	2011	Both TLR3 and TLR4 can be activated by their agonists (polyinosinic:polycytidylic acid and lipopolysaccharide) in Leydig cells and subsequently induce the production of inflammatory factors, such as IL-1beta, IL-6, TNF-alpha, and type 1 interferons (IFN) (IFN-alpha and IFN-beta).	Poly C	68-86	toll-like receptor 4	Mus musculus	14-18
21540291-5	2011	Both TLR3 and TLR4 can be activated by their agonists (polyinosinic:polycytidylic acid and lipopolysaccharide) in Leydig cells and subsequently induce the production of inflammatory factors, such as IL-1beta, IL-6, TNF-alpha, and type 1 interferons (IFN) (IFN-alpha and IFN-beta).	Poly C	68-86	tumor necrosis factor	Mus musculus	215-224
21540291-5	2011	Both TLR3 and TLR4 can be activated by their agonists (polyinosinic:polycytidylic acid and lipopolysaccharide) in Leydig cells and subsequently induce the production of inflammatory factors, such as IL-1beta, IL-6, TNF-alpha, and type 1 interferons (IFN) (IFN-alpha and IFN-beta).	Poly C	68-86	interferon alpha	Mus musculus	256-265
21540291-5	2011	Both TLR3 and TLR4 can be activated by their agonists (polyinosinic:polycytidylic acid and lipopolysaccharide) in Leydig cells and subsequently induce the production of inflammatory factors, such as IL-1beta, IL-6, TNF-alpha, and type 1 interferons (IFN) (IFN-alpha and IFN-beta).	Poly C	68-86	interferon beta 1, fibroblast	Mus musculus	270-278
21296697-0	2011	Toll-like receptor 3 ligand polyinosinic:polycytidylic acid enhances autoimmune disease in a retinal autoimmunity model.	Poly C	41-59	toll like receptor 3	Homo sapiens	0-20
20881901-9	2011	Treatment with not only poly I:C but also LPS induced pancreatitis in IL-10-deficient mice but not in wild-type mice.	Poly C	24-32	interleukin 10	Mus musculus	70-75
21106850-3	2011	Blockade of Akt by a dominant-negative mutant or by short interfering RNA decreased IRF3 activation and IFN-beta expression induced by polyinosinic:polycytidylic acid [poly(I:C)], LPS, TRIF, and TBK1.	Poly C	148-166	thymoma viral proto-oncogene 1	Mus musculus	12-15
21106850-3	2011	Blockade of Akt by a dominant-negative mutant or by short interfering RNA decreased IRF3 activation and IFN-beta expression induced by polyinosinic:polycytidylic acid [poly(I:C)], LPS, TRIF, and TBK1.	Poly C	148-166	interferon regulatory factor 3	Mus musculus	84-88
21106850-3	2011	Blockade of Akt by a dominant-negative mutant or by short interfering RNA decreased IRF3 activation and IFN-beta expression induced by polyinosinic:polycytidylic acid [poly(I:C)], LPS, TRIF, and TBK1.	Poly C	148-166	interferon beta 1, fibroblast	Mus musculus	104-112
21674051-5	2011	METHODOLOGY/PRINCIPAL FINDINGS: We report that polyinosinic:polycytidylic acid (PolyIC, synthetic analogue of dsRNA) induces dramatic apoptosis of mouse splenic conventional DC (cDC) in vivo, predominantly affecting the CD8alpha subset, as shown by flow cytometry-based analysis of splenic DC subsets.	Poly C	60-78	CD8 antigen, alpha chain	Mus musculus	220-228
20817677-2	2011	PCBP4, also called MCG10, is an RBP belonging to the poly(C)-binding protein family and a target of p53 tumor suppressor.	Poly C	53-60	poly(rC) binding protein 4	Mus musculus	0-5
20817677-2	2011	PCBP4, also called MCG10, is an RBP belonging to the poly(C)-binding protein family and a target of p53 tumor suppressor.	Poly C	53-60	retinol binding protein 4, plasma	Mus musculus	32-35
20827338-6	2010	Treatment of HSG cells with polyinosinic: polycytidylic acid (poly(I:C)) significantly increased interferon-gamma-inducible protein 10 (IP-10), interferoninducible T-cell alpha chemoattractant (I-TAC), and regulated on activation, normal T-cells expressed and secreted (RANTES) gene expressions in a concentration-dependent manner.	Poly C	42-60	C-X-C motif chemokine ligand 10	Homo sapiens	97-134
20668230-6	2010	When mAb heavy chain was engineered to express HIV Gag p24, the fusion mAb induced interferon-gamma- and interleukin-2-producing CD4(+) T cells in hDEC205 transgenic mice, if polynocinic polycytidylic acid was coadministered as an adjuvant.	Poly C	187-205	melanoma antigen	Mus musculus	51-54
20668230-6	2010	When mAb heavy chain was engineered to express HIV Gag p24, the fusion mAb induced interferon-gamma- and interleukin-2-producing CD4(+) T cells in hDEC205 transgenic mice, if polynocinic polycytidylic acid was coadministered as an adjuvant.	Poly C	187-205	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	55-58
20224598-5	2010	Promoter, DNA pull-down and chromatin-immunoprecipitation assays revealed that hnRNP K directly interacts with the poly(C) element on the FLIP promoter, resulting in transcriptional activation.	Poly C	115-122	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	79-86
20224598-6	2010	Through iTRAQ-mass spectrometric identification of proteins differentially associated with the poly(C) element or its mutant, nucleolin was determined to be a cofactor of hnRNP K for FLIP activation.	Poly C	95-102	nucleolin	Homo sapiens	126-135
20224598-6	2010	Through iTRAQ-mass spectrometric identification of proteins differentially associated with the poly(C) element or its mutant, nucleolin was determined to be a cofactor of hnRNP K for FLIP activation.	Poly C	95-102	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	171-178
20932317-7	2010	Of the seven reported frameshift mutations occurring in poly C-tracts in RAI1, four cases (~57%) occur at this heptameric C-tract.	Poly C	56-62	retinoic acid induced 1	Homo sapiens	73-77
20519371-0	2010	The poly(c)-binding protein-1 regulates expression of the androgen receptor.	Poly C	4-11	androgen receptor	Homo sapiens	58-75
20610642-4	2010	NLRC5 expression was strongly induced by IFN-gamma and more modestly by LPS and polyinosinic:polycytidylic acid.	Poly C	93-111	NLR family CARD domain containing 5	Homo sapiens	0-5
20827338-6	2010	Treatment of HSG cells with polyinosinic: polycytidylic acid (poly(I:C)) significantly increased interferon-gamma-inducible protein 10 (IP-10), interferoninducible T-cell alpha chemoattractant (I-TAC), and regulated on activation, normal T-cells expressed and secreted (RANTES) gene expressions in a concentration-dependent manner.	Poly C	42-60	C-X-C motif chemokine ligand 10	Homo sapiens	136-141
20827338-6	2010	Treatment of HSG cells with polyinosinic: polycytidylic acid (poly(I:C)) significantly increased interferon-gamma-inducible protein 10 (IP-10), interferoninducible T-cell alpha chemoattractant (I-TAC), and regulated on activation, normal T-cells expressed and secreted (RANTES) gene expressions in a concentration-dependent manner.	Poly C	42-60	C-X-C motif chemokine ligand 11	Homo sapiens	144-192
20827338-6	2010	Treatment of HSG cells with polyinosinic: polycytidylic acid (poly(I:C)) significantly increased interferon-gamma-inducible protein 10 (IP-10), interferoninducible T-cell alpha chemoattractant (I-TAC), and regulated on activation, normal T-cells expressed and secreted (RANTES) gene expressions in a concentration-dependent manner.	Poly C	42-60	C-X-C motif chemokine ligand 11	Homo sapiens	194-199
20827338-6	2010	Treatment of HSG cells with polyinosinic: polycytidylic acid (poly(I:C)) significantly increased interferon-gamma-inducible protein 10 (IP-10), interferoninducible T-cell alpha chemoattractant (I-TAC), and regulated on activation, normal T-cells expressed and secreted (RANTES) gene expressions in a concentration-dependent manner.	Poly C	42-60	C-C motif chemokine ligand 5	Homo sapiens	270-276
20483774-4	2010	A genome-scale functional screening of a transcript library from brain tumors revealed that the microtubule regulator stathmin is an activator of TLR3-dependent signaling in astrocytes, inducing the same set of neuroprotective factors as the known TLR3 agonist polyinosinic:polycytidylic acid.	Poly C	274-292	stathmin 1	Homo sapiens	118-126
20298789-10	2010	IRF8 expression in stimulated trout splenocytes was significantly up-regulated by polyinosinic:polycytidylic acid (poly I:C), trout recombinant (r)IL-15, phorbol 12-myristate 13-acetate (PMA), and phytohaemagglutinin (PHA) treatment whilst remaining refractory towards lipopolysaccharide (LPS) treatment.	Poly C	95-113	interferon regulatory factor 8	Homo sapiens	0-4
20562257-6	2010	IFN-gamma, a cytokine linked to atherosclerosis and graft arteriosclerosis, potentiated the inflammatory responses of intact arteries and cultured vascular smooth muscle cells (VSMCs) to polyinosinic:polycytidylic acid [poly(I:C)] and was necessary for inflammatory responses of VSMC to self-RNA derived from autologous cells.	Poly C	200-218	interferon gamma	Homo sapiens	0-9
20511554-3	2010	Mixtures that included the TLR7/8 agonists R848 or CL075, combined with the TLR3 agonist polyinosinic:polycytidylic acid, yielded 3-d mature DCs that secreted high levels of IL-12(p70), showed strong chemotaxis to CCR7 ligands, and had a positive costimulatory potential.	Poly C	102-120	toll like receptor 3	Homo sapiens	76-80
20483774-4	2010	A genome-scale functional screening of a transcript library from brain tumors revealed that the microtubule regulator stathmin is an activator of TLR3-dependent signaling in astrocytes, inducing the same set of neuroprotective factors as the known TLR3 agonist polyinosinic:polycytidylic acid.	Poly C	274-292	toll like receptor 3	Homo sapiens	146-150
20080226-1	2010	OBJECTIVE: The purpose of this study was to explore the potential of toll-like receptor-3 stimulation, with polyI:C(12)U (poly[l].poly[C(12),U]; rintatolimod [Ampligen; Hemispherx Biopharma, Philadelphia, PA]) to enhance bioactivity of cancer immunotherapies.	Poly C	130-136	toll-like receptor 3	Mus musculus	69-89
20181884-6	2010	CpG-B ODN inhibited induction of IFN-alphabeta by agonists of multiple receptors, including MyD88-dependent TLRs (CpG-A ODN signaling via TLR9, or R837 or Sendai virus signaling via TLR7) and MyD88-independent receptors (polyinosinic:polycytidylic acid signaling via TLR3 or ds break-DNA signaling via a cytosolic pathway).	Poly C	234-252	interferon alpha 1	Homo sapiens	33-36
20167870-2	2010	We investigated the role of polyriboinosinic:polycytidylic acid (poly I:C), a replication-competent viral double-stranded RNA mimic and a specific agonist that recognizes the cellular sensor Toll-like receptor 3 (TLR3), in regulating Valpha14iNKT cell activation.	Poly C	45-63	toll-like receptor 3	Mus musculus	191-211
20167870-2	2010	We investigated the role of polyriboinosinic:polycytidylic acid (poly I:C), a replication-competent viral double-stranded RNA mimic and a specific agonist that recognizes the cellular sensor Toll-like receptor 3 (TLR3), in regulating Valpha14iNKT cell activation.	Poly C	45-63	toll-like receptor 3	Mus musculus	213-217
20164430-0	2010	Cutting edge: polyinosinic:polycytidylic acid boosts the generation of memory CD8 T cells through melanoma differentiation-associated protein 5 expressed in stromal cells.	Poly C	27-45	interferon induced with helicase C domain 1	Mus musculus	98-143
19710456-4	2009	We examined the expression and function of B7 family costimulatory molecules on DCs after activation with the TLR3 agonist, polyinosinic:polycytidylic acid.	Poly C	137-155	toll like receptor 3	Homo sapiens	110-114
19632268-1	2009	Two new interferon stimulated gene 15 (ISG15) family members were identified in a subtractive cDNA library constructed from a mixture of head kidney and spleen of Atlantic cod (Gadus morhua) stimulated with polyinosinic:polycytidylic acid (poly I:C).	Poly C	220-238	ISG15 ubiquitin like modifier	Homo sapiens	39-44
19748983-0	2009	TLR3 ligand polyinosinic:polycytidylic acid induces IL-17A and IL-21 synthesis in human Th cells.	Poly C	25-43	toll like receptor 3	Homo sapiens	0-4
19748983-0	2009	TLR3 ligand polyinosinic:polycytidylic acid induces IL-17A and IL-21 synthesis in human Th cells.	Poly C	25-43	interleukin 17A	Homo sapiens	52-58
19748983-0	2009	TLR3 ligand polyinosinic:polycytidylic acid induces IL-17A and IL-21 synthesis in human Th cells.	Poly C	25-43	interleukin 21	Homo sapiens	63-68
19748983-6	2009	We investigated the expression of IL-17A and IL-21 in human CD4+ T cells in response to stimulation with the TLR3 ligand polyinosinic:polycytidylic acid (poly(I:C)) and the TLR9 ligand CpG.	Poly C	134-152	interleukin 17A	Homo sapiens	34-40
19748983-6	2009	We investigated the expression of IL-17A and IL-21 in human CD4+ T cells in response to stimulation with the TLR3 ligand polyinosinic:polycytidylic acid (poly(I:C)) and the TLR9 ligand CpG.	Poly C	134-152	interleukin 21	Homo sapiens	45-50
19748983-6	2009	We investigated the expression of IL-17A and IL-21 in human CD4+ T cells in response to stimulation with the TLR3 ligand polyinosinic:polycytidylic acid (poly(I:C)) and the TLR9 ligand CpG.	Poly C	134-152	toll like receptor 3	Homo sapiens	109-113
19821527-0	2009	The beta2 integrin CD11b attenuates polyinosinic:polycytidylic acid-induced hepatitis by negatively regulating natural killer cell functions.	Poly C	49-67	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	4-9
19821527-0	2009	The beta2 integrin CD11b attenuates polyinosinic:polycytidylic acid-induced hepatitis by negatively regulating natural killer cell functions.	Poly C	49-67	integrin subunit alpha M	Homo sapiens	19-24
19821527-7	2009	CD11b-deficient NK cells stimulated with or without the TLR3 ligand polyinosinic:polycytidylic acid [poly(I:C)] exhibited more potent cytotoxicity, and higher production of IFN-gamma and granzyme B.	Poly C	81-99	integrin subunit alpha M	Homo sapiens	0-5
19821527-7	2009	CD11b-deficient NK cells stimulated with or without the TLR3 ligand polyinosinic:polycytidylic acid [poly(I:C)] exhibited more potent cytotoxicity, and higher production of IFN-gamma and granzyme B.	Poly C	81-99	toll like receptor 3	Homo sapiens	56-60
19821527-7	2009	CD11b-deficient NK cells stimulated with or without the TLR3 ligand polyinosinic:polycytidylic acid [poly(I:C)] exhibited more potent cytotoxicity, and higher production of IFN-gamma and granzyme B.	Poly C	81-99	interferon gamma	Homo sapiens	173-182
19821527-7	2009	CD11b-deficient NK cells stimulated with or without the TLR3 ligand polyinosinic:polycytidylic acid [poly(I:C)] exhibited more potent cytotoxicity, and higher production of IFN-gamma and granzyme B.	Poly C	81-99	granzyme B	Homo sapiens	187-197
19620256-8	2009	UV-cross-linking studies identify a approximately 44-kDa protein as a major TH mRNA 3"-UTR binding factor, and cAMP induces the 40- to 42-kDa poly(C)-binding protein-2 (PCBP2) in MN9D cells.	Poly C	142-149	poly(rC) binding protein 2	Mus musculus	169-174
19441079-10	2009	ROD1 binding to C21 was strongly inhibited by synthetic RNAs in the order poly A &gt; poly U &gt; poly G = poly C and was weakly inhibited by a synthetic phosphorylated peptide mimicking the C-terminal domain of RNA polymerase II.	Poly C	107-113	polypyrimidine tract binding protein 3	Homo sapiens	0-4
19441079-10	2009	ROD1 binding to C21 was strongly inhibited by synthetic RNAs in the order poly A &gt; poly U &gt; poly G = poly C and was weakly inhibited by a synthetic phosphorylated peptide mimicking the C-terminal domain of RNA polymerase II.	Poly C	107-113	TBL1X/Y related 1	Homo sapiens	16-19
19564349-1	2009	Relative to several other toll-like receptor (TLR) agonists, we found polyinosinic:polycytidylic acid (poly IC) to be the most effective adjuvant for Th1 CD4(+) T cell responses to a dendritic cell (DC)-targeted HIV gag protein vaccine in mice.	Poly C	83-101	negative elongation factor complex member C/D, Th1l	Mus musculus	150-153
19546225-8	2009	Reciprocally, depletion of PLK1 can increase IFN induction in response to RIG-I/SeV or RIG-I/poly(I)-poly(C) treatments.	Poly C	101-108	polo like kinase 1	Homo sapiens	27-31
19546225-8	2009	Reciprocally, depletion of PLK1 can increase IFN induction in response to RIG-I/SeV or RIG-I/poly(I)-poly(C) treatments.	Poly C	101-108	interferon alpha 1	Homo sapiens	45-48
19164348-2	2009	FcepsilonRI-mediated activation of human MCs upregulated TSLP mRNA expression by 5.2+/-2.9-fold, while activation of the MCs using lipopolysaccharide and polyriboinosinic:polyribocytidylic acid failed to upregulate TSLP.	Poly C	171-193	Fc epsilon receptor Ia	Homo sapiens	0-11
19564349-1	2009	Relative to several other toll-like receptor (TLR) agonists, we found polyinosinic:polycytidylic acid (poly IC) to be the most effective adjuvant for Th1 CD4(+) T cell responses to a dendritic cell (DC)-targeted HIV gag protein vaccine in mice.	Poly C	83-101	CD4 antigen	Mus musculus	154-157
19686199-6	2009	Administration of TLR ligands, lipopolysaccharide, and double-stranded RNA polyinosinic:polycytidylic acid, which mimics bacterial or viral infection, activates the IFN signaling pathways, upregulates the expression of IFN-inducible genes, and downregulates the expression of c-fos in taste buds.	Poly C	88-106	interferon alpha 1	Homo sapiens	165-168
19686199-6	2009	Administration of TLR ligands, lipopolysaccharide, and double-stranded RNA polyinosinic:polycytidylic acid, which mimics bacterial or viral infection, activates the IFN signaling pathways, upregulates the expression of IFN-inducible genes, and downregulates the expression of c-fos in taste buds.	Poly C	88-106	interferon alpha 1	Homo sapiens	219-222
19686199-6	2009	Administration of TLR ligands, lipopolysaccharide, and double-stranded RNA polyinosinic:polycytidylic acid, which mimics bacterial or viral infection, activates the IFN signaling pathways, upregulates the expression of IFN-inducible genes, and downregulates the expression of c-fos in taste buds.	Poly C	88-106	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	276-281
19656458-0	2009	Variations in the length of poly-C and poly-T tracts in intron 3 of the human ferrochelatase gene.	Poly C	28-34	ferrochelatase	Homo sapiens	78-92
19656458-1	2009	The third intron of human ferrochelatase (FECH) gene contains according to NCBI, a poly-C (11) and a poly-T (24) tracts which are located approximately 900 bp upstream from the known splice modulating SNP IVS3-48 c/t.	Poly C	83-89	ferrochelatase	Homo sapiens	26-40
19656458-1	2009	The third intron of human ferrochelatase (FECH) gene contains according to NCBI, a poly-C (11) and a poly-T (24) tracts which are located approximately 900 bp upstream from the known splice modulating SNP IVS3-48 c/t.	Poly C	83-89	ferrochelatase	Homo sapiens	42-46
19656458-3	2009	During the course of mutation analysis in the FECH gene among EPP patients, we observed variations in the length of the poly-C and poly-T tracts.	Poly C	120-126	ferrochelatase	Homo sapiens	46-50
19211566-0	2009	Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest.	Poly C	17-24	poly(rC) binding protein 2	Homo sapiens	55-63
19211566-0	2009	Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest.	Poly C	17-24	tumor protein p53	Homo sapiens	89-92
19211566-0	2009	Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest.	Poly C	17-24	poly(rC) binding protein 1	Homo sapiens	42-50
19211566-0	2009	Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest.	Poly C	17-24	cyclin dependent kinase inhibitor 1A	Homo sapiens	153-159
18845337-6	2009	Based on our previous findings that AML cells produce IFN-alpha upon electroporation with the synthetic double-stranded (ds)RNA polyriboinosinic polyribocytidylic acid (poly(I:C)), we hypothesized that dsRNA-loaded tumor cells provide both signals to elicit an NK cell-driven IFN-gamma production.	Poly C	145-167	interferon alpha 1	Homo sapiens	54-63
18845337-6	2009	Based on our previous findings that AML cells produce IFN-alpha upon electroporation with the synthetic double-stranded (ds)RNA polyriboinosinic polyribocytidylic acid (poly(I:C)), we hypothesized that dsRNA-loaded tumor cells provide both signals to elicit an NK cell-driven IFN-gamma production.	Poly C	145-167	interferon gamma	Homo sapiens	276-285
19234166-9	2009	Our studies also show that the ability of RIG-I to respond to stimulation with polyinosinic:polycytidylic acid is abolished when its interaction with HSP90 is inhibited.	Poly C	92-110	DExD/H-box helicase 58	Homo sapiens	42-47
19166911-3	2009	Upon the activation of Toll-like receptor (TLR)-3 expressed in the neuronal cells by polyriboinosinic polyribocytidylic acid (PolyI:C), both IFN-lambda1 and IFN-lambda2/3 expression was significantly induced.	Poly C	126-133	interferon lambda 1	Homo sapiens	141-152
19166911-3	2009	Upon the activation of Toll-like receptor (TLR)-3 expressed in the neuronal cells by polyriboinosinic polyribocytidylic acid (PolyI:C), both IFN-lambda1 and IFN-lambda2/3 expression was significantly induced.	Poly C	126-133	interferon lambda 2	Homo sapiens	157-168
19234166-9	2009	Our studies also show that the ability of RIG-I to respond to stimulation with polyinosinic:polycytidylic acid is abolished when its interaction with HSP90 is inhibited.	Poly C	92-110	heat shock protein 90 alpha family class A member 1	Homo sapiens	150-155
19201850-6	2009	This correlates with a reduced ex vivo and in vivo cytotoxic potential of NK cells isolated from PKCtheta(-/-) mice treated with polyinosinic:polycytidylic acid.	Poly C	142-160	protein kinase C, theta	Mus musculus	97-105
19282652-4	2009	An analogue of viral double-stranded RNA, polyinosinic:polycytidylic acid (poly I:C), which is recognized by TLR3, was injected into autoimmune-prone strains: MRL/Mp mice (MRL/+), MRL/Mp mice with a deficit of Fas (MRL/lpr) and MRL/Mp mice with a deficit of functional FasL (MRL/gld).	Poly C	55-73	toll-like receptor 3	Mus musculus	109-113
19036430-2	2009	We have developed a model vaccine formulation containing ovalbumin (OVA) and the double-stranded RNA analog poly(inosinic acid)-poly(cytidylic acid) (poly(I:C)), a TLR3 agonist.	Poly C	128-148	toll-like receptor 3	Mus musculus	164-168
19038458-3	2009	We provide evidence that Vero cells are deficient in their ability to mount an IRF-3-dependent, IFN-independent antiviral response against either incoming virus particles or polyinosinic:polycytidylic acid (pIC), a dsRNA mimetic.	Poly C	187-205	interferon regulatory factor 3	Chlorocebus sabaeus	79-84
19201880-4	2009	In this study, we show that S100A8 was induced in murine macrophages, and S100A8 and S100A9 in human monocytes and macrophages, by polyinosinic:polycytidylic acid, a dsRNA mimetic.	Poly C	144-162	S100 calcium binding protein A8 (calgranulin A)	Mus musculus	28-34
19201880-4	2009	In this study, we show that S100A8 was induced in murine macrophages, and S100A8 and S100A9 in human monocytes and macrophages, by polyinosinic:polycytidylic acid, a dsRNA mimetic.	Poly C	144-162	S100 calcium binding protein A8 (calgranulin A)	Mus musculus	74-80
19201880-4	2009	In this study, we show that S100A8 was induced in murine macrophages, and S100A8 and S100A9 in human monocytes and macrophages, by polyinosinic:polycytidylic acid, a dsRNA mimetic.	Poly C	144-162	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	85-91
19201880-8	2009	Like IL-10, S100 induction by polyinosinic:polycytidylic acid and by LPS was inhibited by the specific PKR inhibitor 2-aminopurine, indicating a novel IL-10, PKR-dependent pathway.	Poly C	43-61	interleukin 10	Homo sapiens	5-10
19201880-8	2009	Like IL-10, S100 induction by polyinosinic:polycytidylic acid and by LPS was inhibited by the specific PKR inhibitor 2-aminopurine, indicating a novel IL-10, PKR-dependent pathway.	Poly C	43-61	S100 calcium binding protein B	Homo sapiens	12-16
19201880-8	2009	Like IL-10, S100 induction by polyinosinic:polycytidylic acid and by LPS was inhibited by the specific PKR inhibitor 2-aminopurine, indicating a novel IL-10, PKR-dependent pathway.	Poly C	43-61	interleukin 10	Homo sapiens	151-156
18266974-4	2008	We identified PARP-1 by affinity column chromatography using the double-stranded poly(C) element, followed by two-dimensional gel electrophoresis and MALDI-TOF mass spectrometry.	Poly C	81-88	poly (ADP-ribose) polymerase family, member 1	Mus musculus	14-20
19590242-6	2009	METHODS: Expression of PAI-1 and t-PA in immortalized human MC stimulated with polyriboinosinic:polyribocytidylic acid [poly(I:C)] RNA and cytokines were analyzed by real-time RT-PCR and ELISA.	Poly C	96-118	serpin family E member 1	Homo sapiens	23-28
18266974-5	2008	PARP-1 binding to the poly(C) sequence of the MOR gene was sequence-specific as confirmed by the supershift assay.	Poly C	22-29	poly (ADP-ribose) polymerase family, member 1	Mus musculus	0-6
18266974-5	2008	PARP-1 binding to the poly(C) sequence of the MOR gene was sequence-specific as confirmed by the supershift assay.	Poly C	22-29	opioid receptor, mu 1	Mus musculus	46-49
18266974-6	2008	In cotransfection studies, PARP-1 repressed the MOR promoter only when the poly(C) sequence was intact.	Poly C	75-82	poly (ADP-ribose) polymerase family, member 1	Mus musculus	27-33
18266974-6	2008	In cotransfection studies, PARP-1 repressed the MOR promoter only when the poly(C) sequence was intact.	Poly C	75-82	opioid receptor, mu 1	Mus musculus	48-51
18266974-8	2008	Chromatin immunoprecipitation assays showed specific binding of PARP-1 to the double-stranded poly(C) element essential for the MOR promoter.	Poly C	94-101	poly (ADP-ribose) polymerase family, member 1	Mus musculus	64-70
18266974-8	2008	Chromatin immunoprecipitation assays showed specific binding of PARP-1 to the double-stranded poly(C) element essential for the MOR promoter.	Poly C	94-101	opioid receptor, mu 1	Mus musculus	128-131
18266974-10	2008	Our data suggest that PARP-1 can function as a repressor of MOR transcription dependent on the MOR poly(C) sequence.	Poly C	99-106	poly (ADP-ribose) polymerase family, member 1	Mus musculus	22-28
18266974-10	2008	Our data suggest that PARP-1 can function as a repressor of MOR transcription dependent on the MOR poly(C) sequence.	Poly C	99-106	opioid receptor, mu 1	Mus musculus	60-63
18266974-10	2008	Our data suggest that PARP-1 can function as a repressor of MOR transcription dependent on the MOR poly(C) sequence.	Poly C	99-106	opioid receptor, mu 1	Mus musculus	95-98
18922172-9	2008	Functionally, exposure to potassium chloride or intracellular acidification and addition of polyinosinic:polycytidylic acid as mimics of neural activity and double stranded RNA, respectively, differentially affected FMR1 IRES activity.	Poly C	105-123	fragile X messenger ribonucleoprotein 1	Homo sapiens	216-220
18941247-3	2008	Polyinosinic:polycytidylic acid (poly(I:C)) is a synthetic mimetic of viral dsRNA that is known to interact either with endosomal TLR3 (not expressed by human neutrophils) or with cytoplasmic RNA helicases such as melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene I (RIG-I).	Poly C	13-31	toll like receptor 3	Homo sapiens	130-134
18941247-3	2008	Polyinosinic:polycytidylic acid (poly(I:C)) is a synthetic mimetic of viral dsRNA that is known to interact either with endosomal TLR3 (not expressed by human neutrophils) or with cytoplasmic RNA helicases such as melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene I (RIG-I).	Poly C	13-31	interferon induced with helicase C domain 1	Homo sapiens	214-256
18941247-3	2008	Polyinosinic:polycytidylic acid (poly(I:C)) is a synthetic mimetic of viral dsRNA that is known to interact either with endosomal TLR3 (not expressed by human neutrophils) or with cytoplasmic RNA helicases such as melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene I (RIG-I).	Poly C	13-31	interferon induced with helicase C domain 1	Homo sapiens	258-262
18941247-3	2008	Polyinosinic:polycytidylic acid (poly(I:C)) is a synthetic mimetic of viral dsRNA that is known to interact either with endosomal TLR3 (not expressed by human neutrophils) or with cytoplasmic RNA helicases such as melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene I (RIG-I).	Poly C	13-31	DExD/H-box helicase 58	Homo sapiens	268-298
18941247-3	2008	Polyinosinic:polycytidylic acid (poly(I:C)) is a synthetic mimetic of viral dsRNA that is known to interact either with endosomal TLR3 (not expressed by human neutrophils) or with cytoplasmic RNA helicases such as melanoma differentiation-associated gene 5 (MDA5) and retinoic acid-inducible gene I (RIG-I).	Poly C	13-31	DExD/H-box helicase 58	Homo sapiens	300-305
21479492-3	2008	Recently, it was demonstrated that polyinosinic acid:polycytidylic acid [poly(I):poly(C)], a synthetic dsRNA analogue, induced the expression of RIG-I in various cell types, such as vascular endothelial cells and gingival fibroblasts.	Poly C	53-71	DEAD/H box helicase 58	Mus musculus	145-150
21479492-3	2008	Recently, it was demonstrated that polyinosinic acid:polycytidylic acid [poly(I):poly(C)], a synthetic dsRNA analogue, induced the expression of RIG-I in various cell types, such as vascular endothelial cells and gingival fibroblasts.	Poly C	81-88	DEAD/H box helicase 58	Mus musculus	145-150
21479492-4	2008	However, it remains unclear whether RIG-I is induced in osteoblasts in response to poly(I):poly(C).	Poly C	91-98	DEAD/H box helicase 58	Mus musculus	36-41
21479492-5	2008	In the present study, we investigated the effects of poly(I):poly(C) on the expression of RIG-I in mouse osteoblastic MC3T3-E1(E1) cells.	Poly C	61-68	DEAD/H box helicase 58	Mus musculus	90-95
21479492-6	2008	We found that poly(I):poly(C) increased the expression level of RIG-I in E1 cells, and that recombinant interferon-beta (IFN-beta) induced the expression of RIG-I mRNA in E1 cells.	Poly C	22-29	DEAD/H box helicase 58	Mus musculus	64-69
21479492-7	2008	An anti-IFN-beta neu-tralizing antibody partially inhibited poly(I):poly(C)-induced RIG-I expression.	Poly C	68-75	interferon beta 1, fibroblast	Mus musculus	8-16
21479492-7	2008	An anti-IFN-beta neu-tralizing antibody partially inhibited poly(I):poly(C)-induced RIG-I expression.	Poly C	68-75	DEAD/H box helicase 58	Mus musculus	84-89
21479492-8	2008	These results indicate that RIG-I production is induced by poly(I):poly(C)-provoked IFN-beta in mouse osteoblastic E1 cells.	Poly C	67-74	DEAD/H box helicase 58	Mus musculus	28-33
21479492-8	2008	These results indicate that RIG-I production is induced by poly(I):poly(C)-provoked IFN-beta in mouse osteoblastic E1 cells.	Poly C	67-74	interferon beta 1, fibroblast	Mus musculus	84-92
18712788-8	2008	However, KCs isolated from polyinosinic:polycytidylic acid-treated mice expressed significantly higher levels of MHC II and costimulatory molecules than did naive KCs and could stimulate stronger T cell responses.	Poly C	40-58	histocompatibility-2, MHC	Mus musculus	113-119
18453338-4	2008	We identified five poly(C)-binding proteins: heterogeneous nuclear ribonucleoprotein (hnRNP) K, alpha-complex proteins (alphaCP) alphaCP1, alphaCP2, alphaCP2-KL, and alphaCP3.	Poly C	19-26	poly(rC) binding protein 3	Mus musculus	166-174
18725521-4	2008	In this study, we show that polyinosinic:polycytidylic acid (poly[I:C]) and lipopolysaccharide stimulation of macrophages induces pro-IL-1beta processing via a Toll/IL-1R domain-containing adaptor-inducing interferon-beta-dependent signaling pathway that is initiated by TLR3 and TLR4, respectively.	Poly C	41-59	interleukin 1 beta	Homo sapiens	130-142
18725521-4	2008	In this study, we show that polyinosinic:polycytidylic acid (poly[I:C]) and lipopolysaccharide stimulation of macrophages induces pro-IL-1beta processing via a Toll/IL-1R domain-containing adaptor-inducing interferon-beta-dependent signaling pathway that is initiated by TLR3 and TLR4, respectively.	Poly C	41-59	toll like receptor 4	Homo sapiens	160-164
18725521-4	2008	In this study, we show that polyinosinic:polycytidylic acid (poly[I:C]) and lipopolysaccharide stimulation of macrophages induces pro-IL-1beta processing via a Toll/IL-1R domain-containing adaptor-inducing interferon-beta-dependent signaling pathway that is initiated by TLR3 and TLR4, respectively.	Poly C	41-59	toll like receptor 3	Homo sapiens	271-275
18725521-4	2008	In this study, we show that polyinosinic:polycytidylic acid (poly[I:C]) and lipopolysaccharide stimulation of macrophages induces pro-IL-1beta processing via a Toll/IL-1R domain-containing adaptor-inducing interferon-beta-dependent signaling pathway that is initiated by TLR3 and TLR4, respectively.	Poly C	41-59	toll like receptor 4	Homo sapiens	280-284
18505922-8	2008	Furthermore, polyinosinic:polycytidylic acid treatment of the IRF-overexpressing cells showed a more rapid induction of several IFN-regulated genes.	Poly C	26-44	tripartite motif containing 63	Homo sapiens	62-65
18471880-5	2008	Both RIG-I/MDA5 and TLR3 can bind polyriboinosinic:polyribocytidylic acid (poly(I:C)), the synthetic analog of viral dsRNA, and mediate type I IFN production.	Poly C	51-73	DExD/H-box helicase 58	Homo sapiens	5-10
18471880-5	2008	Both RIG-I/MDA5 and TLR3 can bind polyriboinosinic:polyribocytidylic acid (poly(I:C)), the synthetic analog of viral dsRNA, and mediate type I IFN production.	Poly C	51-73	interferon induced with helicase C domain 1	Homo sapiens	11-15
18471880-5	2008	Both RIG-I/MDA5 and TLR3 can bind polyriboinosinic:polyribocytidylic acid (poly(I:C)), the synthetic analog of viral dsRNA, and mediate type I IFN production.	Poly C	51-73	toll like receptor 3	Homo sapiens	20-24
18505922-8	2008	Furthermore, polyinosinic:polycytidylic acid treatment of the IRF-overexpressing cells showed a more rapid induction of several IFN-regulated genes.	Poly C	26-44	interferon alpha 1	Homo sapiens	128-131
18262679-1	2008	Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA and its synthetic analog polyriboinosinic:polyribocytidylic acid (poly(I:C)) and induces type I interferon (IFN), inflammatory cytokine/chemokine production and dendritic cell (DC) maturation via the adaptor protein TICAM-1 (also called TRIF).	Poly C	107-129	toll-like receptor 3	Mus musculus	0-20
18262679-1	2008	Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA and its synthetic analog polyriboinosinic:polyribocytidylic acid (poly(I:C)) and induces type I interferon (IFN), inflammatory cytokine/chemokine production and dendritic cell (DC) maturation via the adaptor protein TICAM-1 (also called TRIF).	Poly C	107-129	toll-like receptor 3	Mus musculus	22-26
18262679-1	2008	Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA and its synthetic analog polyriboinosinic:polyribocytidylic acid (poly(I:C)) and induces type I interferon (IFN), inflammatory cytokine/chemokine production and dendritic cell (DC) maturation via the adaptor protein TICAM-1 (also called TRIF).	Poly C	107-129	toll-like receptor adaptor molecule 1	Mus musculus	281-288
18262679-1	2008	Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA and its synthetic analog polyriboinosinic:polyribocytidylic acid (poly(I:C)) and induces type I interferon (IFN), inflammatory cytokine/chemokine production and dendritic cell (DC) maturation via the adaptor protein TICAM-1 (also called TRIF).	Poly C	107-129	toll-like receptor adaptor molecule 1	Mus musculus	302-306
18191426-2	2008	Among synthetic double-stranded (ds) RNAs, polyriboinosinic: polyribocytidylic acid (poly I:C) activates to produce interferon (IFN) -beta, which plays an important role in anti-viral activity and host-defense.	Poly C	61-83	interferon beta 1, fibroblast	Mus musculus	116-138
18191426-2	2008	Among synthetic double-stranded (ds) RNAs, polyriboinosinic: polyribocytidylic acid (poly I:C) activates to produce interferon (IFN) -beta, which plays an important role in anti-viral activity and host-defense.	Poly C	85-93	interferon beta 1, fibroblast	Mus musculus	116-138
18191426-4	2008	To determine whether poly I:C-induced IFN-beta production is responsible for reduced spontaneous physical activity, we measured poly I:C-induced changes in voluntary wheel-running activity in mice.	Poly C	21-29	interferon beta 1, fibroblast	Mus musculus	38-46
18086896-6	2008	DOG-1 was previously implicated in poly(G)/poly(C) (G/C) tract maintenance during DNA replication.	Poly C	43-50	DNA helicase	Caenorhabditis elegans	0-5
17878381-3	2007	Treatment of RAW 264.7 murine macrophage-like cells with the dsRNA analog polyinosinic:polycytidylic acid (poly-IC) promotes the release of free arachidonic acid that is subsequently converted into PGE2 by the de novo-synthesized cyclooxygenase-2 (COX-2) enzyme.	Poly C	87-105	prostaglandin-endoperoxide synthase 2	Mus musculus	230-246
17625070-0	2007	Novel function of the poly(C)-binding protein alpha CP3 as a transcriptional repressor of the mu opioid receptor gene.	Poly C	22-29	poly(rC) binding protein 3	Mus musculus	46-55
17625070-0	2007	Novel function of the poly(C)-binding protein alpha CP3 as a transcriptional repressor of the mu opioid receptor gene.	Poly C	22-29	opioid receptor, mu 1	Mus musculus	94-112
17625070-4	2007	alphaCP3 bound to the double-stranded poly(C) element essential for the mu opioid receptor (MOR) promoter and repressed the promoter activity at the transcriptional level.	Poly C	38-45	poly(rC) binding protein 3	Mus musculus	0-8
17625070-4	2007	alphaCP3 bound to the double-stranded poly(C) element essential for the mu opioid receptor (MOR) promoter and repressed the promoter activity at the transcriptional level.	Poly C	38-45	opioid receptor, mu 1	Mus musculus	72-90
17625070-4	2007	alphaCP3 bound to the double-stranded poly(C) element essential for the mu opioid receptor (MOR) promoter and repressed the promoter activity at the transcriptional level.	Poly C	38-45	opioid receptor, mu 1	Mus musculus	92-95
17625070-5	2007	We identified alphaCP3 using affinity column chromatography containing the double-stranded poly(C) element and matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry.	Poly C	91-98	poly(rC) binding protein 3	Mus musculus	14-22
17625070-6	2007	AlphaCP3 binding to the poly(C) sequence of the MOR gene was sequence specific, as confirmed by the supershift assay.	Poly C	24-31	poly(rC) binding protein 3	Mus musculus	0-8
17625070-6	2007	AlphaCP3 binding to the poly(C) sequence of the MOR gene was sequence specific, as confirmed by the supershift assay.	Poly C	24-31	opioid receptor, mu 1	Mus musculus	48-51
17625070-7	2007	In cotransfection studies, alphaCP3 repressed the MOR promoter only when the poly(C) sequence was intact.	Poly C	77-84	poly(rC) binding protein 3	Mus musculus	27-35
17625070-7	2007	In cotransfection studies, alphaCP3 repressed the MOR promoter only when the poly(C) sequence was intact.	Poly C	77-84	opioid receptor, mu 1	Mus musculus	50-53
18307775-11	2008	Erythrocytes exposed to heat-inactivated virus or to polyinosinic:polycytidylic acid (polyI:C) or to L-15 medium alone (negative control assays) had minimal late induction (&lt;3.5 relative fold increase) of STAT1 and/or ISG15 and Mx genes, whereas erythrocytes exposed to UV-inactivated virus lacked any cytokine induction.	Poly C	66-84	signal transducer and activator of transcription 1	Homo sapiens	208-213
18307775-11	2008	Erythrocytes exposed to heat-inactivated virus or to polyinosinic:polycytidylic acid (polyI:C) or to L-15 medium alone (negative control assays) had minimal late induction (&lt;3.5 relative fold increase) of STAT1 and/or ISG15 and Mx genes, whereas erythrocytes exposed to UV-inactivated virus lacked any cytokine induction.	Poly C	66-84	ISG15 ubiquitin like modifier	Homo sapiens	221-226
18032677-5	2007	Activation of TLR3 by the synthetic ligand polyinosine:polycytidylic acid (poly I:C) or by mRNA rapidly causes growth cone collapse and irreversibly inhibits neurite extension independent of nuclear factor kappaB.	Poly C	55-73	toll-like receptor 3	Mus musculus	14-18
17982052-3	2007	We now report that administration of the TLR agonists LPS (TLR4) or polyinosinic:polycytidylic acid (TLR3) to mice treated with costimulation blockade prevents alloreactive CD8(+) T cell deletion, primes alloreactive CTLs, and shortens allograft survival.	Poly C	81-99	toll-like receptor 3	Mus musculus	101-105
17878381-3	2007	Treatment of RAW 264.7 murine macrophage-like cells with the dsRNA analog polyinosinic:polycytidylic acid (poly-IC) promotes the release of free arachidonic acid that is subsequently converted into PGE2 by the de novo-synthesized cyclooxygenase-2 (COX-2) enzyme.	Poly C	87-105	prostaglandin-endoperoxide synthase 2	Mus musculus	248-253
17345100-0	2007	STAT3 and COX-2 activation in the guinea-pig brain during fever induced by the Toll-like receptor-3 agonist polyinosinic:polycytidylic acid.	Poly C	121-139	signal transducer and activator of transcription 3	Cavia porcellus	0-5
17368049-5	2007	In both cell lines, Mx and vig-1 transcripts were induced by a dsRNA, poly inosinic: poly cytidylic acid (poly IC), and by Chum salmon reovirus (CSV).	Poly C	85-104	radical S-adenosyl methionine domain-containing protein 2	Oncorhynchus mykiss	27-32
17483910-7	2007	The individual mutation of Arg(36), Asn (39), and Gln(40) resulted in a reduction in the catalytic activity of EDN on poly(U) and poly(C).	Poly C	130-136	ribonuclease A family member 2	Homo sapiens	111-114
17581920-3	2007	ANG II activated hnRNP K as judged by binding to poly(C)- and poly(U)-agarose.	Poly C	49-56	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	17-24
17651019-5	2007	In poly(I).poly(C)-DEAE-dextran-induced PK15 cells, the expression of IFN-alpha2, -alpha3, -alpha4, -alpha8, and -alpha9 after 6-h/24-h inducement in PK15 cells were observed.	Poly C	11-18	interferon alpha-2	Sus scrofa	70-120
17651019-7	2007	The results of realtime quantitative PCR analysis suggested that the expression was time-dependent in pseudorabies virus/poly(I).poly(C)-DEAE-dextran-induced PK15 cells, but in the attenuated swine fever virus-infected PK15 system, the expression level of IFN-alpha subtypes was not obviously time dependent.	Poly C	129-136	interferon-alpha-14	Sus scrofa	256-265
17345100-0	2007	STAT3 and COX-2 activation in the guinea-pig brain during fever induced by the Toll-like receptor-3 agonist polyinosinic:polycytidylic acid.	Poly C	121-139	cytochrome c oxidase subunit II	Cavia porcellus	10-15
17242365-7	2007	Pharmacological inhibition of the kinase JNK blocked induction of miR-155 in response to either polyriboinosinic:polyribocytidylic acid or TNF-alpha, suggesting that miR-155-inducing signals use the JNK pathway.	Poly C	113-135	mitogen-activated protein kinase 8	Homo sapiens	41-44
17368063-6	2007	NCCRP-1 gene expression was not induced by in vitro treatment of head kidney cells with polyinosinic polycytidylic acid (poly I:C) or lipopolysaccharide (LPS), or by in vivo injections with poly I:C or formalin killed Vibrio anguillarum.	Poly C	190-198	F-box only protein 50	Ictalurus punctatus	0-7
17390082-4	2007	The increase in the IFN-beta mRNA level was apparent as early as 1 h after adding poly(I):poly(C) to the culture and peaked at 12 h. Stimulation with poly(I):poly(C) enhanced the expression of CXCL10 mRNA and TLR3 in E1 cells.	Poly C	158-165	interferon beta 1, fibroblast	Mus musculus	20-28
17390082-4	2007	The increase in the IFN-beta mRNA level was apparent as early as 1 h after adding poly(I):poly(C) to the culture and peaked at 12 h. Stimulation with poly(I):poly(C) enhanced the expression of CXCL10 mRNA and TLR3 in E1 cells.	Poly C	158-165	chemokine (C-X-C motif) ligand 10	Mus musculus	193-199
17390082-4	2007	The increase in the IFN-beta mRNA level was apparent as early as 1 h after adding poly(I):poly(C) to the culture and peaked at 12 h. Stimulation with poly(I):poly(C) enhanced the expression of CXCL10 mRNA and TLR3 in E1 cells.	Poly C	158-165	toll-like receptor 3	Mus musculus	209-213
17390082-5	2007	Moreover, poly(I):poly(C) induced tyrosine phosphorylation of the transcription factor STAT1 in E1 cells.	Poly C	18-25	signal transducer and activator of transcription 1	Mus musculus	87-92
17390082-6	2007	An anti-IFN-beta neutralizing antibody partially inhibited poly(I):poly(C)-induced CXCL10 mRNA, TLR3 mRNA and STAT1 phosphorylation.	Poly C	67-74	interferon beta 1, fibroblast	Mus musculus	8-16
17390082-6	2007	An anti-IFN-beta neutralizing antibody partially inhibited poly(I):poly(C)-induced CXCL10 mRNA, TLR3 mRNA and STAT1 phosphorylation.	Poly C	67-74	chemokine (C-X-C motif) ligand 10	Mus musculus	83-89
17390082-6	2007	An anti-IFN-beta neutralizing antibody partially inhibited poly(I):poly(C)-induced CXCL10 mRNA, TLR3 mRNA and STAT1 phosphorylation.	Poly C	67-74	toll-like receptor 3	Mus musculus	96-100
17390082-6	2007	An anti-IFN-beta neutralizing antibody partially inhibited poly(I):poly(C)-induced CXCL10 mRNA, TLR3 mRNA and STAT1 phosphorylation.	Poly C	67-74	signal transducer and activator of transcription 1	Mus musculus	110-115
16870330-5	2007	Mutations in the poly(C)(8) tract of BHD were detected in 3 of 19 MSI-high cases (15.8%), and none of 11 MSI-low cases.	Poly C	17-24	BHD	Homo sapiens	37-40
17321719-1	2007	Poly inosinic:poly cytidylic acid (poly I:C) is a synthetic double-stranded RNA and is a ligand for the Toll like receptor-3.	Poly C	14-33	toll-like receptor 3	Mus musculus	104-124
17390082-1	2007	Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid:polycytidylic acid [poly(I):poly(C)], are recognized by toll-like receptor 3 (TLR3) that induces the production of IFN-beta in many cell types.	Poly C	61-79	toll-like receptor 3	Mus musculus	117-137
17390082-1	2007	Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid:polycytidylic acid [poly(I):poly(C)], are recognized by toll-like receptor 3 (TLR3) that induces the production of IFN-beta in many cell types.	Poly C	61-79	toll-like receptor 3	Mus musculus	139-143
17390082-1	2007	Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid:polycytidylic acid [poly(I):poly(C)], are recognized by toll-like receptor 3 (TLR3) that induces the production of IFN-beta in many cell types.	Poly C	61-79	interferon beta 1, fibroblast	Mus musculus	176-184
17390082-1	2007	Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid:polycytidylic acid [poly(I):poly(C)], are recognized by toll-like receptor 3 (TLR3) that induces the production of IFN-beta in many cell types.	Poly C	89-96	toll-like receptor 3	Mus musculus	117-137
17390082-1	2007	Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid:polycytidylic acid [poly(I):poly(C)], are recognized by toll-like receptor 3 (TLR3) that induces the production of IFN-beta in many cell types.	Poly C	89-96	toll-like receptor 3	Mus musculus	139-143
17390082-1	2007	Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid:polycytidylic acid [poly(I):poly(C)], are recognized by toll-like receptor 3 (TLR3) that induces the production of IFN-beta in many cell types.	Poly C	89-96	interferon beta 1, fibroblast	Mus musculus	176-184
17390082-3	2007	Poly(I):poly(C) markedly increased IFN-beta mRNA level in a dose-dependent manner.	Poly C	8-15	interferon beta 1, fibroblast	Mus musculus	35-43
17390082-4	2007	The increase in the IFN-beta mRNA level was apparent as early as 1 h after adding poly(I):poly(C) to the culture and peaked at 12 h. Stimulation with poly(I):poly(C) enhanced the expression of CXCL10 mRNA and TLR3 in E1 cells.	Poly C	90-97	interferon beta 1, fibroblast	Mus musculus	20-28
17390082-4	2007	The increase in the IFN-beta mRNA level was apparent as early as 1 h after adding poly(I):poly(C) to the culture and peaked at 12 h. Stimulation with poly(I):poly(C) enhanced the expression of CXCL10 mRNA and TLR3 in E1 cells.	Poly C	90-97	chemokine (C-X-C motif) ligand 10	Mus musculus	193-199
17242365-7	2007	Pharmacological inhibition of the kinase JNK blocked induction of miR-155 in response to either polyriboinosinic:polyribocytidylic acid or TNF-alpha, suggesting that miR-155-inducing signals use the JNK pathway.	Poly C	113-135	microRNA 155	Homo sapiens	66-73
17177965-8	2007	In vitro studies evaluating the cell source of these cytokines revealed that polyriboinosinic polyribocytidylic acid (poly I:C) activated retinal vascular endothelial cells produce sE-selectin, sICAM-1 and IFN-beta.	Poly C	118-126	interferon beta 1	Homo sapiens	206-214
17208592-5	2007	The effect of GILZ on LPS-, IL-1beta-, and polyinosinic:polycytidylic acid-induced NF-kappaB activation was assessed in BEAS-2B cells overexpressing GILZ.	Poly C	56-74	TSC22 domain family member 3	Homo sapiens	14-18
16824598-6	2007	Injection of cod with poly I:C strongly induced the expression of ISG15 in all organs investigated.	Poly C	22-30	ISG15 ubiquitin like modifier	Danio rerio	66-71
16824598-8	2007	The expression of ISG15 in head kidney cells was also induced in vitro by treatment with poly I:C, but not significantly with LPS.	Poly C	89-97	ISG15 ubiquitin like modifier	Danio rerio	18-23
17208592-5	2007	The effect of GILZ on LPS-, IL-1beta-, and polyinosinic:polycytidylic acid-induced NF-kappaB activation was assessed in BEAS-2B cells overexpressing GILZ.	Poly C	56-74	nuclear factor kappa B subunit 1	Homo sapiens	83-92
17208592-5	2007	The effect of GILZ on LPS-, IL-1beta-, and polyinosinic:polycytidylic acid-induced NF-kappaB activation was assessed in BEAS-2B cells overexpressing GILZ.	Poly C	56-74	TSC22 domain family member 3	Homo sapiens	149-153
17208592-8	2007	Overexpression of GILZ in BEAS-2B cells significantly inhibited the ability of IL-1beta, LPS, and polyinosinic:polycytidylic acid to activate NF-kappaB, whereas knockdown of GILZ inhibited the ability of dexamethasone to suppress IL-1beta-induced chemokine expression.	Poly C	111-129	TSC22 domain family member 3	Homo sapiens	18-22
17208592-8	2007	Overexpression of GILZ in BEAS-2B cells significantly inhibited the ability of IL-1beta, LPS, and polyinosinic:polycytidylic acid to activate NF-kappaB, whereas knockdown of GILZ inhibited the ability of dexamethasone to suppress IL-1beta-induced chemokine expression.	Poly C	111-129	nuclear factor kappa B subunit 1	Homo sapiens	142-151
18040816-4	2006	New studies were conducted to further evaluate the role of corticosterone in EtOH-mediated changes in production of interleukin-6 (IL-6), IL-10, and IL-12 in serum and peritoneal fluid in mice treated with poly I:C or lipopolysaccharide (LPS).	Poly C	206-214	interleukin 6	Mus musculus	116-129
17014383-11	2007	dsRNA poly (I).poly (C), an activator of PKR protein, increased cell death when osteosarcoma cells were treated with a submaximal concentration of 2-ME.	Poly C	15-23	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	41-44
17426136-4	2007	To reveal the molecular basis of poly(C)-sequence recognition, we have determined the crystal structure, at 1.6 A resolution, of PCBP2 KH3 domain in complex with a 7-nt DNA sequence (5"-AACCCTA-3") corresponding to one repeat of the C-rich strand of human telomeric DNA.	Poly C	33-40	poly(rC) binding protein 2	Homo sapiens	129-134
18040816-8	2006	Inhibition of corticosterone synthesis with aminoglutethimide prevented the increase in IL-10 production caused by EtOH plus poly I:C as compared to poly I:C only.	Poly C	125-133	interleukin 10	Homo sapiens	88-93
18040816-8	2006	Inhibition of corticosterone synthesis with aminoglutethimide prevented the increase in IL-10 production caused by EtOH plus poly I:C as compared to poly I:C only.	Poly C	149-157	interleukin 10	Homo sapiens	88-93
16982913-2	2006	To explore the spectrum of genes induced in human astrocytes by TLR3, we used a microarray approach and the analog polyriboinosinic polyribocytidylic acid (pIC) as ligand.	Poly C	156-159	toll like receptor 3	Homo sapiens	64-68
17192569-8	2006	In the poly I:C-induced fatigue rats, expression of IFN-alpha and 5-HTT increased, while extracellular concentration of 5-HT in the medial prefrontal cortex decreased, probably on account of the enhanced expression of 5-HTT.	Poly C	7-15	huntingtin	Rattus norvegicus	68-71
17192569-8	2006	In the poly I:C-induced fatigue rats, expression of IFN-alpha and 5-HTT increased, while extracellular concentration of 5-HT in the medial prefrontal cortex decreased, probably on account of the enhanced expression of 5-HTT.	Poly C	7-15	huntingtin	Rattus norvegicus	220-223
16682008-0	2006	Interplay of Sps and poly(C) binding protein 1 on the mu-opioid receptor gene expression.	Poly C	21-27	opioid receptor, mu 1	Mus musculus	54-72
16895973-8	2006	Inflammatory stimuli (LPS, polyinosinic:polycytidylic acid, or SAC) induced release of variable quantities of IL-10 from the cell surface.	Poly C	40-58	interleukin 10	Homo sapiens	110-115
16904079-0	2006	Molecular basis underlying the poly C binding protein 1 as a regulator of the proximal promoter of mouse mu-opioid receptor gene.	Poly C	31-37	opioid receptor, mu 1	Mus musculus	105-123
16624932-2	2006	Here, we describe that the IFN-beta released upon stimulation with lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (poly I:C) is responsible for a rapid and sustained signal transducer and activator of transcription 1 and 2 activation and expression of IFN-stimulated genes, such as the transcription factor IFN regulatory factor 7 and the chemokine CXC chemokine ligand 10.	Poly C	108-126	interferon beta 1	Homo sapiens	27-35
16624932-2	2006	Here, we describe that the IFN-beta released upon stimulation with lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (poly I:C) is responsible for a rapid and sustained signal transducer and activator of transcription 1 and 2 activation and expression of IFN-stimulated genes, such as the transcription factor IFN regulatory factor 7 and the chemokine CXC chemokine ligand 10.	Poly C	108-126	signal transducer and activator of transcription 1	Homo sapiens	179-235
16624932-2	2006	Here, we describe that the IFN-beta released upon stimulation with lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (poly I:C) is responsible for a rapid and sustained signal transducer and activator of transcription 1 and 2 activation and expression of IFN-stimulated genes, such as the transcription factor IFN regulatory factor 7 and the chemokine CXC chemokine ligand 10.	Poly C	108-126	interferon alpha 1	Homo sapiens	27-30
16624932-2	2006	Here, we describe that the IFN-beta released upon stimulation with lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (poly I:C) is responsible for a rapid and sustained signal transducer and activator of transcription 1 and 2 activation and expression of IFN-stimulated genes, such as the transcription factor IFN regulatory factor 7 and the chemokine CXC chemokine ligand 10.	Poly C	108-126	interferon alpha 1	Homo sapiens	265-268
16714379-0	2006	Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus.	Poly C	68-90	interferon induced with helicase C domain 1	Mus musculus	18-23
16714379-2	2006	Both RIG-I and mda-5 can bind polyriboinosinic:polyribocytidylic acid (polyI:C), the synthetic analog of viral dsRNA, and mediate type I IFN responses to polyI:C and multiple RNA viruses in vitro.	Poly C	47-69	DEAD/H box helicase 58	Mus musculus	5-10
16714379-2	2006	Both RIG-I and mda-5 can bind polyriboinosinic:polyribocytidylic acid (polyI:C), the synthetic analog of viral dsRNA, and mediate type I IFN responses to polyI:C and multiple RNA viruses in vitro.	Poly C	47-69	interferon induced with helicase C domain 1	Mus musculus	15-20
16518394-4	2006	Using pre-T cell-specific, mature T cell-specific and poly(I).poly(C)-inducible deletions of Smo and antagonists of Smo signaling, we report here that Hh is an essential positive regulator of T cell progenitor differentiation.	Poly C	62-69	smoothened, frizzled class receptor	Homo sapiens	93-96
16518394-4	2006	Using pre-T cell-specific, mature T cell-specific and poly(I).poly(C)-inducible deletions of Smo and antagonists of Smo signaling, we report here that Hh is an essential positive regulator of T cell progenitor differentiation.	Poly C	62-69	smoothened, frizzled class receptor	Homo sapiens	116-119
16623926-5	2006	The synthetic dsRNA analogue polyinosinic acid : polycytidylic acid [Poly(I : C)] could only stimulate IFN-alpha production in enriched mDC but not in pDC.	Poly C	49-67	interferon alpha 1	Homo sapiens	103-112
16623926-5	2006	The synthetic dsRNA analogue polyinosinic acid : polycytidylic acid [Poly(I : C)] could only stimulate IFN-alpha production in enriched mDC but not in pDC.	Poly C	49-67	chemokine (C-C motif) ligand 22	Mus musculus	136-139
16278674-7	2006	Single-stranded poly A, poly G and poly C, as well double-stranded A/T and G/C RNA competed with DNA for AIF binding with a similar efficiency, thus corroborating a computer-calculated molecular model in which the binding site within AIF is the same for distinct nucleic acid species, without a clear sequence specificity.	Poly C	35-41	apoptosis inducing factor mitochondria associated 1	Homo sapiens	105-108
16982647-3	2006	Here we show that PKR"s kinase activity is stimulated in vitro 3- to 5-fold by siRNA duplexes with 19 bp and 2 nt 3"-overhangs, whereas the maximum activation observed for poly(I)*poly(C) was 17-fold over background under the same conditions.	Poly C	180-186	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	18-21
16186123-2	2005	To reveal the molecular basis of poly(C) sequence recognition, we have determined the crystal structure, at 1.7-A resolution, of PCBP2 KH1 in complex with a 7-nucleotide DNA sequence (5"-AACCCTA-3") corresponding to one repeat of the human C-rich strand telomeric DNA.	Poly C	33-40	poly(rC) binding protein 2	Homo sapiens	129-134
16308570-4	2005	In contrast, polyinosinic:polycytidylic acid strongly represses CpG"s as well as its own intrinsic ability to induce PDGF-B mRNA through type I IFN-mediated induction of Smad7, a negative regulator of Smad3/4.	Poly C	26-44	platelet derived growth factor subunit B	Homo sapiens	117-123
16308570-4	2005	In contrast, polyinosinic:polycytidylic acid strongly represses CpG"s as well as its own intrinsic ability to induce PDGF-B mRNA through type I IFN-mediated induction of Smad7, a negative regulator of Smad3/4.	Poly C	26-44	interferon alpha 1	Homo sapiens	144-147
16308570-4	2005	In contrast, polyinosinic:polycytidylic acid strongly represses CpG"s as well as its own intrinsic ability to induce PDGF-B mRNA through type I IFN-mediated induction of Smad7, a negative regulator of Smad3/4.	Poly C	26-44	SMAD family member 7	Homo sapiens	170-175
16308570-4	2005	In contrast, polyinosinic:polycytidylic acid strongly represses CpG"s as well as its own intrinsic ability to induce PDGF-B mRNA through type I IFN-mediated induction of Smad7, a negative regulator of Smad3/4.	Poly C	26-44	SMAD family member 3	Homo sapiens	201-206
16324116-4	2005	Serotonin transporter (5-HTT) mRNA also increased on days 1 and 8 after poly I:C injection in the same brain regions where IFN-alpha mRNA increased.	Poly C	72-80	solute carrier family 6 member 4	Rattus norvegicus	0-21
16324116-4	2005	Serotonin transporter (5-HTT) mRNA also increased on days 1 and 8 after poly I:C injection in the same brain regions where IFN-alpha mRNA increased.	Poly C	72-80	huntingtin	Rattus norvegicus	25-28
15507307-8	2004	When macrophages infected with isolates 3, 7, or 12 were treated with polycytidylic acid (polyI:C), IFN-alpha production was enhanced.	Poly C	70-88	interferon alpha 1	Homo sapiens	100-109
15955566-12	2005	However, a complete phosphorothioate ODN with a central CpG-motif and poly-C sequences, that did not induce IFN, readily induced IL-6 both in the presence and absence of lipofectin.	Poly C	70-76	interleukin 6	Equus caballus	129-133
15967798-7	2005	Labeled AB transcripts formed specific complexes with hepatoma cell extracts that contained the poly(C)-binding proteins, iso-alphaCP1 and -alphaCP2, which have well defined roles as translation regulators.	Poly C	96-103	poly(rC) binding protein 1	Homo sapiens	126-134
16321207-12	2005	The concentrations of IL-8 in the supernatant of the culture fluid of THEC cells increased along with the time of stimulation of LPS and Poly: C, ligands for TLR3 and 4, and reached to 297.33 pg/ml and 229.67 pg/ml respectively 8 hours after, 10 times and 7 times those of the control group (both P &lt; 0.05).	Poly C	137-144	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
15705927-6	2005	Polyinosine: polycytidylic acid (poly I:C), a TLR3 ligand, led to a 9-fold increase.	Poly C	13-31	toll-like receptor 3	Mus musculus	46-50
15705927-7	2005	Levels of aP2 protein were significantly increased in LPS or zymosan-treated macrophages compared with control or poly I:C-treated cells.	Poly C	114-122	fatty acid binding protein 4, adipocyte	Mus musculus	10-13
15731341-6	2005	A model of alphaCP1-KH3 with poly(C)-RNA was generated by homology to a recently reported RNA-bound KH domain structure and suggests the molecular basis for oligonucleotide binding and poly(C)-RNA specificity.	Poly C	29-36	poly(rC) binding protein 1	Homo sapiens	11-19
15731341-6	2005	A model of alphaCP1-KH3 with poly(C)-RNA was generated by homology to a recently reported RNA-bound KH domain structure and suggests the molecular basis for oligonucleotide binding and poly(C)-RNA specificity.	Poly C	185-192	poly(rC) binding protein 1	Homo sapiens	11-19
15607693-11	2005	We also found that activation of a PKR mutant by the polyinosinic acid:polycytidylic acid (poly I:C) is impaired when compared with the wild-type PKR.	Poly C	71-89	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	35-38
15607693-11	2005	We also found that activation of a PKR mutant by the polyinosinic acid:polycytidylic acid (poly I:C) is impaired when compared with the wild-type PKR.	Poly C	71-89	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	146-149
16020515-5	2005	Many poly-C tract length differences and specific point mutations seen in these same donors but assayed 2 years earlier were still present in the new CD34+ samples.	Poly C	5-11	CD34 molecule	Homo sapiens	150-154
16123342-0	2005	Interferon-alpha as a mediator of polyinosinic:polycytidylic acid-induced type 1 diabetes.	Poly C	47-65	interferon alpha	Mus musculus	0-16
15789358-2	2005	Using surface plasmon resonance technology we demonstrated the capacity of the poly(A):poly(U) (pA:pU) motif to bind with high affinity to a totally synthetic Tat protein and to inhibit more efficiently the Tat/transactivation response element (TAR) RNA interaction as compared to the poly(I):poly(C) (pI:pC) motif.	Poly C	293-300	tyrosine aminotransferase	Homo sapiens	159-162
15789358-2	2005	Using surface plasmon resonance technology we demonstrated the capacity of the poly(A):poly(U) (pA:pU) motif to bind with high affinity to a totally synthetic Tat protein and to inhibit more efficiently the Tat/transactivation response element (TAR) RNA interaction as compared to the poly(I):poly(C) (pI:pC) motif.	Poly C	293-300	tyrosine aminotransferase	Homo sapiens	207-210
15780087-8	2005	Rapid IRF-1 hyperexpression was also noted following stimulation of mesangial cells with peptidoglycan, poly I:poly C, <protein-id="15978">interferon-gamma?	Poly C	111-117	interferon regulatory factor 1	Mus musculus	6-11
15507307-8	2004	When macrophages infected with isolates 3, 7, or 12 were treated with polycytidylic acid (polyI:C), IFN-alpha production was enhanced.	Poly C	90-97	interferon alpha 1	Homo sapiens	100-109
15507307-9	2004	Cells infected with isolate 3 and treated with polyI:C showed the most consistent and strongest enhancement of IFN-alpha production.	Poly C	47-54	interferon alpha 1	Homo sapiens	111-120
15507307-10	2004	It was demonstrated that the relatively low concentrations of IFN-alpha produced by isolate 3 contributed to the enhanced IFN-alpha synthesis in response to polyI:C.	Poly C	157-164	interferon alpha 1	Homo sapiens	62-71
15507307-10	2004	It was demonstrated that the relatively low concentrations of IFN-alpha produced by isolate 3 contributed to the enhanced IFN-alpha synthesis in response to polyI:C.	Poly C	157-164	interferon alpha 1	Homo sapiens	122-131
15507307-11	2004	Isolates 7 and 12 significantly suppressed the enhanced IFN-alpha production by isolate 3 in polyI:C treated cells.	Poly C	93-100	interferon alpha 1	Homo sapiens	56-65
15507307-15	2004	Furthermore, a PRRSV field isolate strongly enhance polyI:C-induced IFN-alpha production in PAM cultures and this priming effect was suppressed by other PRRSV isolates.	Poly C	52-59	interferon alpha 1	Homo sapiens	68-71
15342370-2	2004	We show that IFN-alpha and polyinosinic:polycytidylic acid (p-I:C) synergize with the "classical" type-1-polarizing cytokine cocktail [tumor necrosis factor alpha (TNFalpha)/IL-1beta/IFNgamma], allowing for serum-free generation of fully mature type-1-polarized DCs (DC1).	Poly C	40-58	tumor necrosis factor	Homo sapiens	164-172
15342370-2	2004	We show that IFN-alpha and polyinosinic:polycytidylic acid (p-I:C) synergize with the "classical" type-1-polarizing cytokine cocktail [tumor necrosis factor alpha (TNFalpha)/IL-1beta/IFNgamma], allowing for serum-free generation of fully mature type-1-polarized DCs (DC1).	Poly C	40-58	interleukin 1 beta	Homo sapiens	174-182
15342370-2	2004	We show that IFN-alpha and polyinosinic:polycytidylic acid (p-I:C) synergize with the "classical" type-1-polarizing cytokine cocktail [tumor necrosis factor alpha (TNFalpha)/IL-1beta/IFNgamma], allowing for serum-free generation of fully mature type-1-polarized DCs (DC1).	Poly C	40-58	interferon gamma	Homo sapiens	183-191
14566081-0	2003	Poly-C specific ribonuclease activity correlates with increased concentrations of IL-6, IL-8 and sTNFR55/sTNFR75 in plasma of patients with acute pancreatitis.	Poly C	0-6	interleukin 6	Homo sapiens	82-86
15028736-5	2004	We then characterized the ATPase activity of Dbp9p with respect to cofactor specificity; the activity was found to be severely inhibited by yeast total RNA and moderately inhibited by poly(U), poly(A), and poly(C) but to be stimulated by yeast genomic DNA and salmon sperm DNA.	Poly C	206-212	ATP-dependent DNA/RNA helicase	Saccharomyces cerevisiae S288C	45-50
15048731-8	2004	The LPS and poly-I-C enhancement of bradykinin-induced contraction was inhibited by the transcriptional inhibitor actinomycin-D, dexamethasone, the proteasome inhibitor MG-132 and the c-Jun N-terminal kinase (JNK) inhibitor SP600125.	Poly C	12-20	mitogen-activated protein kinase 8	Mus musculus	184-207
15048731-8	2004	The LPS and poly-I-C enhancement of bradykinin-induced contraction was inhibited by the transcriptional inhibitor actinomycin-D, dexamethasone, the proteasome inhibitor MG-132 and the c-Jun N-terminal kinase (JNK) inhibitor SP600125.	Poly C	12-20	mitogen-activated protein kinase 8	Mus musculus	209-212
15048731-9	2004	LPS and poly-I-C induced translocation of NF-kappa B p65 to the nucleus and up-regulation of kinin B(1) and B(2) receptor mRNA.	Poly C	8-16	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	42-52
15048731-9	2004	LPS and poly-I-C induced translocation of NF-kappa B p65 to the nucleus and up-regulation of kinin B(1) and B(2) receptor mRNA.	Poly C	8-16	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	53-56
15048731-9	2004	LPS and poly-I-C induced translocation of NF-kappa B p65 to the nucleus and up-regulation of kinin B(1) and B(2) receptor mRNA.	Poly C	8-16	bradykinin receptor, beta 1	Mus musculus	93-121
14585200-6	2003	Poly(I)-poly(C) induced two IFN transcripts in head kidney of Atlantic salmon.	Poly C	8-15	interferon alpha 1	Homo sapiens	28-31
14566081-0	2003	Poly-C specific ribonuclease activity correlates with increased concentrations of IL-6, IL-8 and sTNFR55/sTNFR75 in plasma of patients with acute pancreatitis.	Poly C	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
12590136-7	2003	Poly(U), poly(C), and poly(G) were also found to be 12-30-fold better inhibitors of CCR4 compared with poly(A), supporting the observation that CCR4 contains a non-poly(A)-specific binding site.	Poly C	9-16	CCR4-NOT core exoribonuclease subunit CCR4	Saccharomyces cerevisiae S288C	84-88
12819017-3	2003	Virus infection or viral mimic [polyinosinic acid:polycytidylic acid (polyI:C)] treatment of human colon M-SMCs in vitro increases cell surface hyaluronan (HA), and nonactivated mononuclear leukocytes bind to virus-induced HA structures by interactions that involve the HA-binding receptor CD44.	Poly C	50-68	CD44 molecule (Indian blood group)	Homo sapiens	290-294
10837825-10	2000	Point mutations in the NF-H binding site which prevented formation of the poly(C)-sensitive complex also stabilized the fusion mRNA.	Poly C	74-81	neurofilament heavy chain	Rattus norvegicus	23-27
12689664-1	2003	A converting activity was characterized in human diploid fibroblasts, which secrete 72IL-8 and 77IL-8 in treatment with IFN-beta and poly I: poly C.	Poly C	141-147	C-X-C motif chemokine ligand 8	Homo sapiens	86-101
14574737-2	2003	An increase of the enzyme activity was established in the presence of FGA, concanavaline A, poly(I).poly(C) in vitro.	Poly C	100-107	fibrinogen alpha chain	Rattus norvegicus	70-73
12011088-0	2002	Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3"-untranslated region of the androgen receptor messenger RNA.	Poly C	25-32	androgen receptor	Homo sapiens	119-136
12011088-9	2002	Poly(C)-binding protein-1 and -2 (CP1 and CP2), previously implicated in the control of mRNA turnover and translation, also bound avidly to the UC-rich region.	Poly C	0-7	ceruloplasmin	Homo sapiens	42-45
12054664-3	2002	Here, we show the mAb to TLR3 suppressed poly(I):poly(C)-mediated IFN-beta production by human fibroblasts naturally expressing TLR3 on their surface.	Poly C	49-56	toll like receptor 3	Homo sapiens	25-29
12054664-3	2002	Here, we show the mAb to TLR3 suppressed poly(I):poly(C)-mediated IFN-beta production by human fibroblasts naturally expressing TLR3 on their surface.	Poly C	49-56	interferon beta 1	Homo sapiens	66-74
12054664-3	2002	Here, we show the mAb to TLR3 suppressed poly(I):poly(C)-mediated IFN-beta production by human fibroblasts naturally expressing TLR3 on their surface.	Poly C	49-56	toll like receptor 3	Homo sapiens	128-132
12096926-7	2002	When melanocytes and melanoma cells were treated with a potent IFN inducer, polyinosinic:polycytidylic acid (poly I:C), the mRNA expression of both IFN-alpha and IFN-beta was significantly upregulated.	Poly C	89-107	interferon alpha 1	Homo sapiens	63-66
12096926-7	2002	When melanocytes and melanoma cells were treated with a potent IFN inducer, polyinosinic:polycytidylic acid (poly I:C), the mRNA expression of both IFN-alpha and IFN-beta was significantly upregulated.	Poly C	89-107	interferon alpha 1	Homo sapiens	148-157
12096926-7	2002	When melanocytes and melanoma cells were treated with a potent IFN inducer, polyinosinic:polycytidylic acid (poly I:C), the mRNA expression of both IFN-alpha and IFN-beta was significantly upregulated.	Poly C	89-107	interferon beta 1	Homo sapiens	162-170
11958862-5	2002	Hypoxia-inducible expression of poly(C)-binding protein 1 was mediated by p38 mitogen-activated protein kinase, while hypoxia-reducible expression of poly(C)-binding protein 2 was mediated by protein kinase C. Immunostaining showed that poly(C)-binding protein 1, but not poly(C)-binding protein 2, expression was increased in the ischemic boundary zone (penumbra) of the frontal cortex after 90 min of ischemia, and persisted for at least 72 h after reperfusion.	Poly C	32-38	mitogen activated protein kinase 14	Rattus norvegicus	74-77
11958862-5	2002	Hypoxia-inducible expression of poly(C)-binding protein 1 was mediated by p38 mitogen-activated protein kinase, while hypoxia-reducible expression of poly(C)-binding protein 2 was mediated by protein kinase C. Immunostaining showed that poly(C)-binding protein 1, but not poly(C)-binding protein 2, expression was increased in the ischemic boundary zone (penumbra) of the frontal cortex after 90 min of ischemia, and persisted for at least 72 h after reperfusion.	Poly C	32-39	mitogen activated protein kinase 14	Rattus norvegicus	74-77
11722649-7	2001	RA + PIC-treated rats had significantly higher levels of interleukin (IL)-10, IL-12, and signal transducer and activator of transcription-1 (STAT-1) mRNA (P &lt; 0.05), and STAT-1 protein (P &lt; 0.02).	Poly C	5-8	signal transducer and activator of transcription 1	Rattus norvegicus	89-139
11722649-7	2001	RA + PIC-treated rats had significantly higher levels of interleukin (IL)-10, IL-12, and signal transducer and activator of transcription-1 (STAT-1) mRNA (P &lt; 0.05), and STAT-1 protein (P &lt; 0.02).	Poly C	5-8	signal transducer and activator of transcription 1	Rattus norvegicus	141-147
11722649-7	2001	RA + PIC-treated rats had significantly higher levels of interleukin (IL)-10, IL-12, and signal transducer and activator of transcription-1 (STAT-1) mRNA (P &lt; 0.05), and STAT-1 protein (P &lt; 0.02).	Poly C	5-8	signal transducer and activator of transcription 1	Rattus norvegicus	173-179
11522298-4	2001	BLOX-1-CHO adhesion to FN-coated plates can also be suppressed by scavenger receptor ligands, such as OxLDL, polyinosinic acid (poly I), and dextran sulfate, but not by native LDL, acetylated LDL, polycytidylic acid (poly C), or chondroitin sulfate.	Poly C	197-215	oxidized low density lipoprotein receptor 1	Bos taurus	0-6
11522298-4	2001	BLOX-1-CHO adhesion to FN-coated plates can also be suppressed by scavenger receptor ligands, such as OxLDL, polyinosinic acid (poly I), and dextran sulfate, but not by native LDL, acetylated LDL, polycytidylic acid (poly C), or chondroitin sulfate.	Poly C	197-215	fibronectin 1	Bos taurus	23-25
11522298-4	2001	BLOX-1-CHO adhesion to FN-coated plates can also be suppressed by scavenger receptor ligands, such as OxLDL, polyinosinic acid (poly I), and dextran sulfate, but not by native LDL, acetylated LDL, polycytidylic acid (poly C), or chondroitin sulfate.	Poly C	217-223	oxidized low density lipoprotein receptor 1	Bos taurus	0-6
11522298-4	2001	BLOX-1-CHO adhesion to FN-coated plates can also be suppressed by scavenger receptor ligands, such as OxLDL, polyinosinic acid (poly I), and dextran sulfate, but not by native LDL, acetylated LDL, polycytidylic acid (poly C), or chondroitin sulfate.	Poly C	217-223	fibronectin 1	Bos taurus	23-25
11433018-4	2001	In vitro, Nhp2p interacts with high affinity with RNAs containing irregular stem-loop structures but shows weak affinity for poly(A), poly(C) or for double-stranded RNAs.	Poly C	134-140	snoRNA-binding protein NHP2	Saccharomyces cerevisiae S288C	10-15
12836375-7	2001	Poly(C) and poly(A) was retained in the SPG column at low temperature, though poly(G) passed by SPG column without interaction.	Poly C	0-7	SPG16	Homo sapiens	40-43
10891498-6	2000	By generating cell lines that inducibly express either wild-type or mutated forms of MCG10 and MCG10as, we found that MCG10 and MCG10as can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. In addition, we found that MCG10 and MCG10as, through their KH domains, can bind poly(C) and that their RNA-binding activity is necessary for inducing apoptosis and cell cycle arrest.	Poly C	304-310	poly(rC) binding protein 4	Homo sapiens	85-90
10891498-6	2000	By generating cell lines that inducibly express either wild-type or mutated forms of MCG10 and MCG10as, we found that MCG10 and MCG10as can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. In addition, we found that MCG10 and MCG10as, through their KH domains, can bind poly(C) and that their RNA-binding activity is necessary for inducing apoptosis and cell cycle arrest.	Poly C	304-310	poly(rC) binding protein 4	Homo sapiens	95-100
10891498-6	2000	By generating cell lines that inducibly express either wild-type or mutated forms of MCG10 and MCG10as, we found that MCG10 and MCG10as can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. In addition, we found that MCG10 and MCG10as, through their KH domains, can bind poly(C) and that their RNA-binding activity is necessary for inducing apoptosis and cell cycle arrest.	Poly C	304-310	poly(rC) binding protein 4	Homo sapiens	95-100
10891498-6	2000	By generating cell lines that inducibly express either wild-type or mutated forms of MCG10 and MCG10as, we found that MCG10 and MCG10as can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. In addition, we found that MCG10 and MCG10as, through their KH domains, can bind poly(C) and that their RNA-binding activity is necessary for inducing apoptosis and cell cycle arrest.	Poly C	304-310	poly(rC) binding protein 4	Homo sapiens	95-100
10891498-6	2000	By generating cell lines that inducibly express either wild-type or mutated forms of MCG10 and MCG10as, we found that MCG10 and MCG10as can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. In addition, we found that MCG10 and MCG10as, through their KH domains, can bind poly(C) and that their RNA-binding activity is necessary for inducing apoptosis and cell cycle arrest.	Poly C	304-310	poly(rC) binding protein 4	Homo sapiens	95-100
10891498-6	2000	By generating cell lines that inducibly express either wild-type or mutated forms of MCG10 and MCG10as, we found that MCG10 and MCG10as can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. In addition, we found that MCG10 and MCG10as, through their KH domains, can bind poly(C) and that their RNA-binding activity is necessary for inducing apoptosis and cell cycle arrest.	Poly C	304-310	poly(rC) binding protein 4	Homo sapiens	95-100
10891498-7	2000	Furthermore, we found that the level of the poly(C) binding MCG10 protein is increased in cells treated with the DNA-damaging agent camptothecin in a p53-dependent manner.	Poly C	44-51	poly(rC) binding protein 4	Homo sapiens	60-65
10891498-7	2000	Furthermore, we found that the level of the poly(C) binding MCG10 protein is increased in cells treated with the DNA-damaging agent camptothecin in a p53-dependent manner.	Poly C	44-51	tumor protein p53	Homo sapiens	150-153
10899117-2	2000	dsRNA [polyinosinic:polycytidylic acid (poly IC)]-stimulated inducible nitric oxide synthase, interleukin (IL)-1alpha and IL-1beta mRNA expression, nitrite formation and IL-1 release are attenuated in RAW264.7 cells stably expressing dominant negative (dn) mutants of PKR.	Poly C	20-38	interleukin 1 alpha	Mus musculus	94-117
10899117-2	2000	dsRNA [polyinosinic:polycytidylic acid (poly IC)]-stimulated inducible nitric oxide synthase, interleukin (IL)-1alpha and IL-1beta mRNA expression, nitrite formation and IL-1 release are attenuated in RAW264.7 cells stably expressing dominant negative (dn) mutants of PKR.	Poly C	20-38	interleukin 1 beta	Mus musculus	122-130
10899117-2	2000	dsRNA [polyinosinic:polycytidylic acid (poly IC)]-stimulated inducible nitric oxide synthase, interleukin (IL)-1alpha and IL-1beta mRNA expression, nitrite formation and IL-1 release are attenuated in RAW264.7 cells stably expressing dominant negative (dn) mutants of PKR.	Poly C	20-38	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	268-271
12586220-8	2003	In contrast, IL-10 was minimally induced by poly I:C alone, but it was substantially induced by poly I:C plus EtOH.	Poly C	44-52	interleukin 10	Mus musculus	13-18
12586220-8	2003	In contrast, IL-10 was minimally induced by poly I:C alone, but it was substantially induced by poly I:C plus EtOH.	Poly C	96-104	interleukin 10	Mus musculus	13-18
12590973-8	2003	Furthermore, RTG-2 cells responded to treatment with poly(I).poly(C) or to infection by infectious pancreatic necrosis virus, IPNV, by increasing eIF2alpha phosphorylation.	Poly C	61-68	eukaryotic translation initiation factor 2A	Danio rerio	146-155
12525633-5	2003	Treatment with the known IFN inducer polyinosinic acid-polycytidylic acid (poly[I]-poly[C]) resulted in an increase in zfIFN mRNA transcripts.	Poly C	83-89	interferon phi 1	Danio rerio	25-28
12525633-5	2003	Treatment with the known IFN inducer polyinosinic acid-polycytidylic acid (poly[I]-poly[C]) resulted in an increase in zfIFN mRNA transcripts.	Poly C	83-89	interferon phi 1	Danio rerio	119-124
12401717-3	2002	We previously identified a disease-susceptibility locus in the BBDR rat, iddm4, which is associated with the development of autoimmune diabetes after treatment with polyinosinic:polycytidylic acid and an antibody that depletes ART2(+) regulatory cells.	Poly C	178-196	Insulin dependent diabetes mellitus QTL 8	Rattus norvegicus	73-78
12186889-6	2002	poly(C)] and encephalomyocarditis virus were greatly enhanced by IFN-gamma pretreatment (priming) of wild-type cells or of mutant cells lacking an IFN-alpha/beta response; these include the primary induction of dsRNA-inducible mRNAs, including IFN-beta mRNA, and, to a lesser extent, the dsRNA-mediated activation of the p38 mitogen-activated protein (MAP) kinase(s).	Poly C	0-7	interferon gamma	Homo sapiens	65-74
12186889-6	2002	poly(C)] and encephalomyocarditis virus were greatly enhanced by IFN-gamma pretreatment (priming) of wild-type cells or of mutant cells lacking an IFN-alpha/beta response; these include the primary induction of dsRNA-inducible mRNAs, including IFN-beta mRNA, and, to a lesser extent, the dsRNA-mediated activation of the p38 mitogen-activated protein (MAP) kinase(s).	Poly C	0-7	interferon alpha 1	Homo sapiens	147-156
12186889-6	2002	poly(C)] and encephalomyocarditis virus were greatly enhanced by IFN-gamma pretreatment (priming) of wild-type cells or of mutant cells lacking an IFN-alpha/beta response; these include the primary induction of dsRNA-inducible mRNAs, including IFN-beta mRNA, and, to a lesser extent, the dsRNA-mediated activation of the p38 mitogen-activated protein (MAP) kinase(s).	Poly C	0-7	interferon beta 1	Homo sapiens	244-252
12186889-6	2002	poly(C)] and encephalomyocarditis virus were greatly enhanced by IFN-gamma pretreatment (priming) of wild-type cells or of mutant cells lacking an IFN-alpha/beta response; these include the primary induction of dsRNA-inducible mRNAs, including IFN-beta mRNA, and, to a lesser extent, the dsRNA-mediated activation of the p38 mitogen-activated protein (MAP) kinase(s).	Poly C	0-7	mitogen-activated protein kinase 1	Homo sapiens	321-324
11742128-2	2002	Oligocytidylic acids, ranging from dinucleotides to heptanucleotides, were obtained by RNase A digestion of poly(C).	Poly C	108-115	ribonuclease pancreatic	Bos taurus	87-94
11410650-9	2001	We also demonstrate that poly(A) is a better competitor than poly(G) or poly(C) of the Pop2p nuclease activity.	Poly C	72-79	CCR4-NOT core DEDD family RNase subunit POP2	Saccharomyces cerevisiae S288C	87-92
10713453-5	2000	As the hnRNP K in vertebrates the M(r) 55 000 Drosophila Hrb57A/Q18 protein strongly binds to poly(C) in vitro and is ubiquitously present in nuclei active in transcription.	Poly C	94-101	Heterogeneous nuclear ribonucleoprotein K	Drosophila melanogaster	7-14
10713453-5	2000	As the hnRNP K in vertebrates the M(r) 55 000 Drosophila Hrb57A/Q18 protein strongly binds to poly(C) in vitro and is ubiquitously present in nuclei active in transcription.	Poly C	94-101	Heterogeneous nuclear ribonucleoprotein K	Drosophila melanogaster	57-63
10713453-5	2000	As the hnRNP K in vertebrates the M(r) 55 000 Drosophila Hrb57A/Q18 protein strongly binds to poly(C) in vitro and is ubiquitously present in nuclei active in transcription.	Poly C	94-101	Heterogeneous nuclear ribonucleoprotein K	Drosophila melanogaster	64-67
10704250-5	2000	Poly(I).poly(C) induces ISG12 in a cell line-dependent manner, whereas none of the other cytokines tested elicited a response.	Poly C	8-15	interferon alpha inducible protein 27	Homo sapiens	24-29
10687957-4	2000	Lactoferrin exerted RNase activity on poly C with an activity of 2.15 U/mg.	Poly C	38-44	lactotransferrin	Bos taurus	0-11
10400313-5	1999	In the presence of poly(I):poly(C), the PKR activator, we detected both an increased phosphorylation of eIF-2alpha and an increment in the autophosphorylation of PKR.	Poly C	27-34	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	40-43
10632727-6	2000	Removing either one of the terminal disulfide bonds liberates a similar number of residues and has a similar effect on conformational stability, decreasing the midpoint of the thermal transition by almost 40 degrees C. The disulfide variants catalyze the cleavage of poly(cytidylic acid) with values of kcat/Km that are 2- to 40-fold less than that of wild-type RNase A.	Poly C	267-287	ribonuclease pancreatic	Bos taurus	362-369
10504400-11	1999	On the contrary, the activity of the RNase A oligomers, from dimer to pentamer, on yeast RNA and poly(C) (Kunitz assay) is lower than that of monomeric RNase A.	Poly C	97-103	ribonuclease pancreatic	Bos taurus	37-44
10432301-1	1999	Eukaryotic translation initiation factor 2alpha (eIF-2alpha), a target molecule of the interferon-inducible double-stranded-RNA-dependent protein kinase (PKR), was cleaved in apoptotic Saos-2 cells on treatment with poly(I).poly(C) or tumour necrosis factor alpha.	Poly C	224-230	eukaryotic translation initiation factor 2A	Homo sapiens	0-47
10432301-1	1999	Eukaryotic translation initiation factor 2alpha (eIF-2alpha), a target molecule of the interferon-inducible double-stranded-RNA-dependent protein kinase (PKR), was cleaved in apoptotic Saos-2 cells on treatment with poly(I).poly(C) or tumour necrosis factor alpha.	Poly C	224-230	eukaryotic translation initiation factor 2A	Homo sapiens	49-59
10432301-1	1999	Eukaryotic translation initiation factor 2alpha (eIF-2alpha), a target molecule of the interferon-inducible double-stranded-RNA-dependent protein kinase (PKR), was cleaved in apoptotic Saos-2 cells on treatment with poly(I).poly(C) or tumour necrosis factor alpha.	Poly C	224-230	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	154-157
11543371-4	1999	Specifically, at a constant [poly(C)], values of d[G2p]/dt typically increased with [G]o with a parabolic upward curvature.	Poly C	29-36	crystallin gamma E, pseudogene	Homo sapiens	51-54
11543371-5	1999	At a constant [G]o, values of d[G2p]/dt increase with [poly(C)], but level off at the higher poly(C) concentrations.	Poly C	55-62	crystallin gamma E, pseudogene	Homo sapiens	32-35
11543371-5	1999	At a constant [G]o, values of d[G2p]/dt increase with [poly(C)], but level off at the higher poly(C) concentrations.	Poly C	93-100	crystallin gamma E, pseudogene	Homo sapiens	32-35
10553506-0	1999	A poly(C) repeat polymorphism in the promoter of the IL-10 gene in NZB mice.	Poly C	2-8	interleukin 10	Mus musculus	53-58
10455157-3	1999	The two major cytoplasmic poly(C)-binding proteins in mammalian cells, alphaCP-1 and alphaCP-2, are implicated in a spectrum of post-transcriptional controls.	Poly C	26-33	poly(rC) binding protein 1	Homo sapiens	71-80
10455157-3	1999	The two major cytoplasmic poly(C)-binding proteins in mammalian cells, alphaCP-1 and alphaCP-2, are implicated in a spectrum of post-transcriptional controls.	Poly C	26-33	poly(rC) binding protein 2	Homo sapiens	85-94
10445881-9	1999	A specific poly(C)-sensitive complex formed on the TAPA-1 and coxII 3" UTRs consistent with the binding of aCP1.	Poly C	11-18	CD81 molecule	Homo sapiens	51-57
10445881-9	1999	A specific poly(C)-sensitive complex formed on the TAPA-1 and coxII 3" UTRs consistent with the binding of aCP1.	Poly C	11-18	acid phosphatase 1	Homo sapiens	107-111
10400313-5	1999	In the presence of poly(I):poly(C), the PKR activator, we detected both an increased phosphorylation of eIF-2alpha and an increment in the autophosphorylation of PKR.	Poly C	27-34	eukaryotic translation initiation factor 2A	Homo sapiens	104-114
10400313-5	1999	In the presence of poly(I):poly(C), the PKR activator, we detected both an increased phosphorylation of eIF-2alpha and an increment in the autophosphorylation of PKR.	Poly C	27-34	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	162-165
10329716-7	1999	In vitro, PKCdelta binds K protein via the highly interactive KI domain, an interaction that is blocked by poly(C) RNA.	Poly C	107-114	protein kinase C delta	Homo sapiens	10-18
10068686-0	1999	Identification of the poly(C) binding protein in the complex associated with the 3" untranslated region of erythropoietin messenger RNA.	Poly C	22-29	erythropoietin	Homo sapiens	107-121
10220316-6	1999	T45G RNase A, which catalyzes the processive cleavage of poly(A) but the distributive cleavage of poly(cytidylic acid) [poly(C)], has the same preference.	Poly C	98-118	ribonuclease pancreatic	Bos taurus	5-12
10220316-6	1999	T45G RNase A, which catalyzes the processive cleavage of poly(A) but the distributive cleavage of poly(cytidylic acid) [poly(C)], has the same preference.	Poly C	120-127	ribonuclease pancreatic	Bos taurus	5-12
9920723-3	1999	When poly I:poly C was applied to the upper compartment, IFN was secreted predominantly from the apical membrane.	Poly C	12-18	interferon alpha 1	Homo sapiens	57-60
9920723-4	1999	Inversely, poly I:poly C applied to the lower compartment caused preferential IFN secretion from the basolateral membrane.	Poly C	18-24	interferon alpha 1	Homo sapiens	78-81
9920723-0	1999	Stimulation side-dependent asymmetrical secretion of poly I:poly C-induced interferon-beta from polarized epithelial cell lines.	Poly C	60-66	interferon beta 1	Homo sapiens	75-90
9675022-6	1998	On synthetic polyribonucleotide substrates, the RNase activity of Zn alpha 2gp is specific for pyrimidine residues [poly(C) and poly(U) equally] and cleaves only single-stranded RNA.	Poly C	116-123	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	66-78
9920723-1	1999	Mode of secretion of poly I:poly C-induced IFN was examined using epithelial cell lines in a bicameral culture system.	Poly C	28-34	interferon alpha 1	Homo sapiens	43-46
9724524-6	1998	Wild-type RNase A and the K66A, K7A/R10A, and K7A/R10A/K66A variants were evaluated as catalysts for the cleavage of poly(cytidylic acid) [poly(C)] and for their abilities to bind to single-stranded DNA, a substrate analogue.	Poly C	117-137	ribonuclease pancreatic	Bos taurus	10-17
9724524-6	1998	Wild-type RNase A and the K66A, K7A/R10A, and K7A/R10A/K66A variants were evaluated as catalysts for the cleavage of poly(cytidylic acid) [poly(C)] and for their abilities to bind to single-stranded DNA, a substrate analogue.	Poly C	139-146	ribonuclease pancreatic	Bos taurus	10-17
9724524-8	1998	The kcat/Km values for poly(C) cleavage by the K66A, K7A/R10A, and K7A/R10A/K66A variants were 3-fold, 60-fold, and 300-fold lower, respectively, than that of wild-type RNase A.	Poly C	23-30	ribonuclease pancreatic	Bos taurus	169-176
9756612-2	1998	However, the dose of poly I:poly C required for efficient IFN induction is so high as occasionally to be cytotoxic.	Poly C	28-34	interferon alpha 1	Homo sapiens	58-61
9756612-3	1998	In this work, we examined the IFN-inducibility of poly I:poly C complexed with several cationic reagents in mouse fibroblast L cells and found that Lipofectin and LipofectACE can induce the production of a substantial amount of type I IFNs (mostly beta-type) even at a two-order lower dose compared with poly I:poly C alone.	Poly C	57-63	interferon alpha 1	Homo sapiens	30-33
9756612-3	1998	In this work, we examined the IFN-inducibility of poly I:poly C complexed with several cationic reagents in mouse fibroblast L cells and found that Lipofectin and LipofectACE can induce the production of a substantial amount of type I IFNs (mostly beta-type) even at a two-order lower dose compared with poly I:poly C alone.	Poly C	311-317	interferon alpha 1	Homo sapiens	30-33
9624140-5	1998	FLAG-Fmrp exhibited selectivity for binding poly(G) &gt; poly(U) &gt;&gt; poly(C) or poly(A).	Poly C	74-80	fragile X messenger ribonucleoprotein 1	Homo sapiens	5-9
9234743-3	1997	One of the protein activities in this multiprotein complex is a poly(C)-binding activity which consists of two proteins, alphaCP1 and alphaCP2.	Poly C	64-71	poly(rC) binding protein 1	Homo sapiens	121-129
21528262-5	1997	The ability of the transcript to activate PKR was sensitive to ribonuclease V1 and was abolished by the addition of high concentrations of poly(I).poly(C).	Poly C	147-154	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	42-45
9294150-6	1997	Inhibition of RNase L with a dominant negative mutant suppressed poly (I).poly (C)-induced apoptosis in interferon-primed fibroblasts.	Poly C	74-82	ribonuclease L	Homo sapiens	14-21
9629309-7	1998	Poly (i)-poly (c)-induced IFN-alpha production by monocytes was inhibited by glucocorticoids in the AIDS-C group and controls (approx.	Poly C	9-17	interferon alpha 1	Homo sapiens	26-35
9682215-12	1998	These changes are within or in close proximity to a CCTG sequence and a poly(C) tract, both of which are shown in other systems to be mutation hotspots.	Poly C	72-79	chaperonin containing TCP1 subunit 3	Homo sapiens	52-56
9682215-14	1998	The present observations suggest that the short SP-B sequence containing the CCTG motif and the poly(C) tract is a mutation hotspot.	Poly C	96-103	surfactant protein B	Homo sapiens	48-52
9388488-3	1997	Using human monocyte-derived macrophages as a model of brain microglia, physiological levels of apolipoprotein-E were found to stimulate nitric oxide (NO) production in polyinosinic:polycytidylic acid (poly I:C) primed cells.	Poly C	182-200	apolipoprotein E	Homo sapiens	96-112
9287326-8	1997	A UV cross-linking assay also indicated poly(U)- and poly(C)-stimulated labeling of rSUG1 with [alpha-32P]ATP.	Poly C	53-60	proteasome 26S subunit, ATPase 5	Rattus norvegicus	84-89
9234743-3	1997	One of the protein activities in this multiprotein complex is a poly(C)-binding activity which consists of two proteins, alphaCP1 and alphaCP2.	Poly C	64-71	poly(rC) binding protein 2	Homo sapiens	134-142
9264143-7	1997	After poly(I):poly(C) stimulation, monocytes from AIDS-GR produce much more IFN alpha than other AIDS patients.	Poly C	14-21	interferon alpha 1	Homo sapiens	76-85
22358527-5	1997	The production of interferon-beta (IFN-beta) by MG-63 cells super-induced by Poly (I): Poly (C) was shown to decrease in a dose dependent manner upon the addition of 0.01-10 mug/ml of cortisol or noradrenaline (NA).	Poly C	87-95	interferon beta 1	Homo sapiens	18-33
22358527-5	1997	The production of interferon-beta (IFN-beta) by MG-63 cells super-induced by Poly (I): Poly (C) was shown to decrease in a dose dependent manner upon the addition of 0.01-10 mug/ml of cortisol or noradrenaline (NA).	Poly C	87-95	interferon beta 1	Homo sapiens	35-43
8937426-2	1996	Previous studies have suggested that LPS- or polyIC-induced downregulation of P450 was due to endogenously released inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1, interleukin-6, and interferons (IFNs).	Poly C	45-51	tumor necrosis factor	Rattus norvegicus	147-174
8937426-2	1996	Previous studies have suggested that LPS- or polyIC-induced downregulation of P450 was due to endogenously released inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1, interleukin-6, and interferons (IFNs).	Poly C	45-51	tumor necrosis factor	Rattus norvegicus	176-185
8937426-2	1996	Previous studies have suggested that LPS- or polyIC-induced downregulation of P450 was due to endogenously released inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1, interleukin-6, and interferons (IFNs).	Poly C	45-51	interleukin 6	Rattus norvegicus	203-216
7556162-0	1995	Activation of the double-stranded-RNA-activated protein kinase and induction of vascular cell adhesion molecule-1 by poly (I).poly (C) in endothelial cells.	Poly C	126-134	vascular cell adhesion molecule 1	Homo sapiens	80-113
8871564-1	1996	The murine poly(C)-binding protein (mCBP) was previously shown to belong to the group of K-homology (KH) proteins by virtue of its homology to hnRNP-K.	Poly C	11-18	CREB binding protein	Mus musculus	36-40
8871564-1	1996	The murine poly(C)-binding protein (mCBP) was previously shown to belong to the group of K-homology (KH) proteins by virtue of its homology to hnRNP-K.	Poly C	11-18	heterogeneous nuclear ribonucleoprotein K	Mus musculus	143-150
8760418-3	1996	cDNA cloning and sequencing of the genomes of ERV-1 and ERV-2 between the poly(C) and poly(A) tracts showed that the serotypes are heterogeneous.	Poly C	74-80	growth factor, augmenter of liver regeneration	Homo sapiens	46-51
7556077-3	1995	One or more of the proteins within this alpha-complex contain strong polycytosine [poly(C)] binding (alpha PCB) activity.	Poly C	83-90	pyruvate carboxylase	Homo sapiens	107-110
8814275-3	1996	Furthermore, IgM-/- mice showed increased natural killer (NK) activity upon exposure to either lymphocytic choriomeningitis virus (LCMV) or to poly(I).poly(C), while NK activity in untreated IgM-/- mice was within normal ranges.	Poly C	151-157	immunoglobulin heavy constant mu	Mus musculus	13-16
8811006-4	1996	Poly(U) and poly(C) were better than poly(A) at stimulating the NTPase activities, in contrast to other flaviviral NTPases.	Poly C	12-19	inosine triphosphatase	Homo sapiens	64-70
8844858-6	1996	The free energies with which Y97F, Y97A, and Y97G RNase A bind to the rate-limiting transition state during the cleavage of poly(cytidylic acid) are diminished by 0.74, 3.3, and 3.8 kcal/mol, respectively.	Poly C	124-144	ribonuclease pancreatic	Bos taurus	50-57
7589141-5	1995	Taken together, these data suggest that poly I:C is a Th1-inducing agent whose activity is mediated by its ability to stimulate the production of IFN-alpha and IL-12 by monocytes.	Poly C	40-48	negative elongation factor complex member C/D	Homo sapiens	54-57
7589141-5	1995	Taken together, these data suggest that poly I:C is a Th1-inducing agent whose activity is mediated by its ability to stimulate the production of IFN-alpha and IL-12 by monocytes.	Poly C	40-48	interferon alpha 1	Homo sapiens	146-155
7556162-8	1995	Poly (I).poly (C) induces VCAM-1 mRNA levels that are dramatically higher and sustained longer than levels induced by IL-1 beta.	Poly C	9-17	vascular cell adhesion molecule 1	Homo sapiens	26-32
7556162-9	1995	Although phosphorylation of eIF2 alpha interferes with protein translation, sufficient VCAM-1 mRNA translation occurs in response to poly (I).poly (C) to yield VCAM-1 protein levels that are similar to levels that are induced by IL-1 beta.	Poly C	142-150	vascular cell adhesion molecule 1	Homo sapiens	87-93
7556162-9	1995	Although phosphorylation of eIF2 alpha interferes with protein translation, sufficient VCAM-1 mRNA translation occurs in response to poly (I).poly (C) to yield VCAM-1 protein levels that are similar to levels that are induced by IL-1 beta.	Poly C	142-150	vascular cell adhesion molecule 1	Homo sapiens	160-166
7556162-10	1995	This suggests that the higher, sustained VCAM-1 mRNA levels that occur in response to incubation with poly (I).poly (C) compensate for the partial translational block resulting from increased eIF2 alpha phosphorylation.	Poly C	111-118	vascular cell adhesion molecule 1	Homo sapiens	41-47
7556162-10	1995	This suggests that the higher, sustained VCAM-1 mRNA levels that occur in response to incubation with poly (I).poly (C) compensate for the partial translational block resulting from increased eIF2 alpha phosphorylation.	Poly C	111-118	eukaryotic translation initiation factor 2A	Homo sapiens	192-202
7749068-5	1995	IFN-alpha and poly(I).poly(C) elicited small, transient gamma 2 responses in a few of the non-lymphoid cell lines, whereas none of the other six cytokines tested elicited a response.	Poly C	22-29	interferon alpha 1	Homo sapiens	0-9
7749068-5	1995	IFN-alpha and poly(I).poly(C) elicited small, transient gamma 2 responses in a few of the non-lymphoid cell lines, whereas none of the other six cytokines tested elicited a response.	Poly C	22-29	tryptophanyl-tRNA synthetase 1	Homo sapiens	56-63
8407977-4	1993	The enzyme displayed only ATPase and deoxy-ATPase activity that was stimulated preferentially by poly(C).	Poly C	97-104	dynein axonemal heavy chain 8	Homo sapiens	26-32
8069921-3	1994	LPS synergizes with low doses of IL-2, gamma interferon, poly(I).poly(C) 12U.	Poly C	65-72	interleukin 2	Mus musculus	33-37
7908289-6	1994	This fragment of the 3"-untranslated region of TH mRNA is rich in pyrimidine nucleotides, and the binding of cytoplasmic protein to this fragment was reduced by competition with other polypyrimidine sequences including poly(C) but not poly(U) polymers.	Poly C	219-226	tyrosine hydroxylase	Rattus norvegicus	47-49
7507969-9	1994	Polyinosinic acid:polycytidylic acid induced significantly higher amounts of IFN but lower levels of TNF and IL-6 than imiquimod.	Poly C	18-36	tumor necrosis factor	Mus musculus	101-104
7507969-9	1994	Polyinosinic acid:polycytidylic acid induced significantly higher amounts of IFN but lower levels of TNF and IL-6 than imiquimod.	Poly C	18-36	interleukin 6	Mus musculus	109-113
7893828-5	1994	In the present work, PKR immobilized either by immunoprecipitation or by affinity precipitation on Agpoly(I) poly(C) was found to autophosphorylate in a dsRNA-independent manner when incubated in the presence of a detergent lysis buffer and ATP.	Poly C	109-116	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	21-24
7969187-3	1994	GM-CSF and IFN-beta genes were expressed in response to PMA/A23187, poly(I):poly(C), IL-1 alpha, forskolin, or LPS stimulation in differentiated P19 cells, whereas IL-3 and IL-4 genes were not expressed.	Poly C	76-83	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	0-6
7969187-3	1994	GM-CSF and IFN-beta genes were expressed in response to PMA/A23187, poly(I):poly(C), IL-1 alpha, forskolin, or LPS stimulation in differentiated P19 cells, whereas IL-3 and IL-4 genes were not expressed.	Poly C	76-83	interferon beta 1, fibroblast	Mus musculus	11-19
8402903-3	1993	IRF-1-deficient fibroblasts lacked the normally observed type I IFN induction by poly(I):poly(C), while they induced type I IFN to similar levels as the wild type following Newcastle disease virus (NDV) infection.	Poly C	89-96	interferon regulatory factor 1	Mus musculus	0-5
8407977-4	1993	The enzyme displayed only ATPase and deoxy-ATPase activity that was stimulated preferentially by poly(C).	Poly C	97-104	dynein axonemal heavy chain 8	Homo sapiens	43-49
7905506-4	1993	Treatment of HeLa cells with poly(I):poly(C) stimulated PKR autophosphorylation in vivo.	Poly C	37-44	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	56-59
1590774-5	1992	RNA blotting analysis demonstrates that interferon-alpha (IFN-alpha) and its inducers, i.e. poly(I).poly(C), bacterial lipopolysaccharide (LPS) and tilorone (2,7-bis-[2-(diethylamino)ethoxy]fluoren-9-one), increase the expression of XD mRNA in liver.	Poly C	100-106	interferon alpha	Mus musculus	40-56
7506512-4	1993	Non-viral inducers, such as poly(rl).poly(rC), induce exclusively IFN-beta whereas viruses such as Sendai and Newcastle Disease Virus (NDV) induce mixtures of IFN-alpha subtypes and IFN-beta.	Poly C	37-45	interferon alpha 1	Homo sapiens	66-69
1602741-10	1992	SMC treated with poly(I):poly(C) or Newcastle Disease virus elaborated biologically active IFN-beta as well.	Poly C	25-32	interferon beta 1	Homo sapiens	91-99
7683591-4	1993	Polyinosinic acid (poly I), a known scavenger receptor ligand, significantly induced the expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin on human umbilical vein endothelial cells when compared with polycytidylic acid (poly C), a structurally related compound to poly I, which does not bind to the scavenger receptor.	Poly C	266-284	intercellular adhesion molecule 1	Homo sapiens	103-136
7683591-4	1993	Polyinosinic acid (poly I), a known scavenger receptor ligand, significantly induced the expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin on human umbilical vein endothelial cells when compared with polycytidylic acid (poly C), a structurally related compound to poly I, which does not bind to the scavenger receptor.	Poly C	286-292	intercellular adhesion molecule 1	Homo sapiens	103-136
1590774-5	1992	RNA blotting analysis demonstrates that interferon-alpha (IFN-alpha) and its inducers, i.e. poly(I).poly(C), bacterial lipopolysaccharide (LPS) and tilorone (2,7-bis-[2-(diethylamino)ethoxy]fluoren-9-one), increase the expression of XD mRNA in liver.	Poly C	100-106	interferon alpha	Mus musculus	58-67
1379284-3	1992	Coculture of M phi with IFN-gamma and polyinosinic-polycytidylic acid [poly(I):poly(C)] resulted in the reduction of Ia expression in comparison with those cultured without poly(I):poly(C).	Poly C	79-86	interferon gamma	Homo sapiens	24-33
1379284-3	1992	Coculture of M phi with IFN-gamma and polyinosinic-polycytidylic acid [poly(I):poly(C)] resulted in the reduction of Ia expression in comparison with those cultured without poly(I):poly(C).	Poly C	79-85	interferon gamma	Homo sapiens	24-33
1379284-4	1992	Pretreatment of M phi with poly(I):poly(C) or a bacterial lipopolysaccharide (LPS), which is also a potent IFN inducer, in vitro or in vivo, before being exposed to IFN-gamma was also effective in suppressing the Ia expression.	Poly C	35-42	interferon alpha 1	Homo sapiens	107-110
1940796-4	1991	Injection of mice with polyinosinic acid.polycytidylic acid (poly I.C), an inducer of macrophage IFN-alpha production, also suppresses the anti-IgD antibody-induced IgE response and stimulates the IgG2a response; these effects are blocked by a sheep antibody that neutralizes mouse IFN-alpha/beta.	Poly C	41-59	interferon alpha	Mus musculus	97-106
1762062-6	1991	Although oxygen exposure per se decreased the total level of lung cytochrome P-450, poly I: poly C per se induced a deeper decrease to levels similar in air- or oxygen-exposed rats.	Poly C	92-98	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	66-90
1940796-4	1991	Injection of mice with polyinosinic acid.polycytidylic acid (poly I.C), an inducer of macrophage IFN-alpha production, also suppresses the anti-IgD antibody-induced IgE response and stimulates the IgG2a response; these effects are blocked by a sheep antibody that neutralizes mouse IFN-alpha/beta.	Poly C	41-59	immunoglobulin heavy variable V1-9	Mus musculus	197-202
1940796-4	1991	Injection of mice with polyinosinic acid.polycytidylic acid (poly I.C), an inducer of macrophage IFN-alpha production, also suppresses the anti-IgD antibody-induced IgE response and stimulates the IgG2a response; these effects are blocked by a sheep antibody that neutralizes mouse IFN-alpha/beta.	Poly C	41-59	interferon alpha	Mus musculus	282-291
1940796-4	1991	Injection of mice with polyinosinic acid.polycytidylic acid (poly I.C), an inducer of macrophage IFN-alpha production, also suppresses the anti-IgD antibody-induced IgE response and stimulates the IgG2a response; these effects are blocked by a sheep antibody that neutralizes mouse IFN-alpha/beta.	Poly C	61-69	interferon alpha	Mus musculus	97-106
1940796-4	1991	Injection of mice with polyinosinic acid.polycytidylic acid (poly I.C), an inducer of macrophage IFN-alpha production, also suppresses the anti-IgD antibody-induced IgE response and stimulates the IgG2a response; these effects are blocked by a sheep antibody that neutralizes mouse IFN-alpha/beta.	Poly C	61-69	immunoglobulin heavy variable V1-9	Mus musculus	197-202
1940796-4	1991	Injection of mice with polyinosinic acid.polycytidylic acid (poly I.C), an inducer of macrophage IFN-alpha production, also suppresses the anti-IgD antibody-induced IgE response and stimulates the IgG2a response; these effects are blocked by a sheep antibody that neutralizes mouse IFN-alpha/beta.	Poly C	61-69	interferon alpha	Mus musculus	282-291
1931812-7	1991	Immunization of mice with Brucella abortus or poly (I).poly (C) resulted in induction of Ly-6A/E expression by virtually all B and T cells, whereas injection of G alpha M delta led to peak induction of Ly-6A/E by approximately 50% of both B and T cells.	Poly C	55-63	lymphocyte antigen 6 complex, locus A	Mus musculus	89-96
1681618-4	1991	A single major virus-specific polypeptide of Mr = 25,000 (p25) bound to the poly(rI).poly(rC)-Sepharose.	Poly C	85-93	tubulin polymerization promoting protein	Homo sapiens	58-61
1944260-9	1991	The inhibition degree of bovine liver tyrosyl-tRNA synthetase decreased in the order: poly (G) greater than poly (I) greater than poly (I).poly (C) greater than poly (G).poly (C) greater than poly (C) greater than poly (A).	Poly C	139-146	tyrosyl-tRNA synthetase 1	Bos taurus	38-61
1904722-1	1991	Kinetic parameters kcat and KM were measured for cleavage of poly I, poly A, poly U, poly C and poly I poly C by guanyl-specific RNases Sa, Pb1 and T1 and compared with that of guanyl-preferential RNase Bi.	Poly C	103-109	polybromo 1	Homo sapiens	140-143
1944260-9	1991	The inhibition degree of bovine liver tyrosyl-tRNA synthetase decreased in the order: poly (G) greater than poly (I) greater than poly (I).poly (C) greater than poly (G).poly (C) greater than poly (C) greater than poly (A).	Poly C	170-177	tyrosyl-tRNA synthetase 1	Bos taurus	38-61
1944260-9	1991	The inhibition degree of bovine liver tyrosyl-tRNA synthetase decreased in the order: poly (G) greater than poly (I) greater than poly (I).poly (C) greater than poly (G).poly (C) greater than poly (C) greater than poly (A).	Poly C	170-177	tyrosyl-tRNA synthetase 1	Bos taurus	38-61
1706245-1	1990	Administration of the interferon inducer polyriboinosinic acid.polyribocytidylic acid (poly rl.poly rC) (10 mg/kg, ip) to male rats suppressed the constitutive hepatic expression of the male-specific cytochrome P-450 [AH, reduced-flavoprotein/oxygen oxidoreductase (RH hydroxylating), EC 1.14.14.1] isozyme P450IIC11 (P-450h) to 21% of control levels within 24 hr.	Poly C	63-85	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	318-324
1872877-1	1991	The administration of the interferone inducer, polyriboinosinic.polyribocytidylic acid, inhibited the rise of activities of thymidylate synthase and thymidine kinase as well as DNA content in 24 h-regenerating rat liver in a dose dependent manner.	Poly C	64-86	thymidylate synthetase	Rattus norvegicus	124-144
1703958-12	1991	The activation of the dsRNA-dependent eIF-2 alpha kinase by regulatory RNA was prevented by addition of a high concentration of poly(I).poly(C).	Poly C	136-143	eukaryotic translation initiation factor 2A	Mus musculus	38-49
1848905-1	1991	When an oligonucleotide primer pG10 is incubated with the nucleotide analogue 9-[3-hydroxy-2-(hydroxymethyl)prop-1-yl] guanine diphosphate (pGp, I) in the presence of poly(C), addition of the monomer occurs almost exclusively at the 5"-terminal phosphate rather than the 3"-terminal cis-glycol.	Poly C	167-173	phosphoglycolate phosphatase	Homo sapiens	140-143
2211840-4	1990	The biological effect of Poly(I).Poly(C)-induced feedback interferon is inhibited by the addition of sarcolectins, which also abolishes cellular refractoriness to repeated IFN induction.	Poly C	33-40	interferon alpha 1	Homo sapiens	58-68
2211840-4	1990	The biological effect of Poly(I).Poly(C)-induced feedback interferon is inhibited by the addition of sarcolectins, which also abolishes cellular refractoriness to repeated IFN induction.	Poly C	33-40	interferon alpha 1	Homo sapiens	172-175
2211840-5	1990	Similarly, sequential association of, first, Poly(I).Poly(C); 4-5 h later, sarcolectin restores the full capacity of both to promote cell growth, unrestrained by IFN.	Poly C	53-60	keratin 7	Homo sapiens	75-86
2211840-5	1990	Similarly, sequential association of, first, Poly(I).Poly(C); 4-5 h later, sarcolectin restores the full capacity of both to promote cell growth, unrestrained by IFN.	Poly C	53-60	interferon alpha 1	Homo sapiens	162-165
2153928-3	1990	IFN-alpha mRNA remained undetectable in poly(I)-poly(C)-treated Daudi cells either before or after priming.	Poly C	48-55	interferon alpha 1	Homo sapiens	0-9
2310829-1	1990	Interleukin-6 (IL-6), a multifunctional cytokine produced in monocytes, fibroblasts, endothelial cells, and keratinocytes, is induced by a variety of stimulating signals, including lipopolysaccharide (LPS), poly (I), poly (C), IL-1, tumor necrosis factor (TNF), and platelet-derived growth factor.	Poly C	217-224	interleukin 6	Homo sapiens	0-13
2310829-1	1990	Interleukin-6 (IL-6), a multifunctional cytokine produced in monocytes, fibroblasts, endothelial cells, and keratinocytes, is induced by a variety of stimulating signals, including lipopolysaccharide (LPS), poly (I), poly (C), IL-1, tumor necrosis factor (TNF), and platelet-derived growth factor.	Poly C	217-224	interleukin 6	Homo sapiens	15-19
2107102-1	1990	Transcription of human interferon (IFN) gamma gene is induced in human peripheral lymphocyte nylon-nonadherent cells (NNA cells) by double strand RNA poly I:poly C [(1985) J. Interferon Res.	Poly C	157-163	interferon gamma	Homo sapiens	23-45
2107102-4	1990	For induction of IFN gamma gene expression, only initial 4 h treatment of poly I:poly C to NNA cells is sufficient.	Poly C	81-87	interferon gamma	Homo sapiens	17-26
2107102-5	1990	Addition of inhibitor of protein synthesis, cycloheximide (CHX), at an early stage of induction periods (0-4 h) inhibits the IFN gamma induction by poly I:poly C.	Poly C	155-161	interferon gamma	Homo sapiens	125-134
2107102-6	1990	Cell free translation assay using RNAs isolated from NNA cells which are induced by poly I:poly C in the presence of CHX reveals that in these RNAs, IFN gamma mRNA does not exist.	Poly C	91-97	interferon gamma	Homo sapiens	149-158
2407240-3	1990	Other stimulators of interleukin 6 production in chondrocytes include tumour necrosis factor-alpha, polyriboinosinic: polyribocytidylic acid and bacterial lipopolysaccharide.	Poly C	118-140	interleukin 6	Homo sapiens	21-34
34949739-2	2022	In macrophages, necroptosis can be induced by co-treatment with Toll-like receptor (TLR) ligands (lipopolysaccharide (LPS) for TLR4 and polyinosinic-polycytidylic acid (poly I:C) for TLR3) and a cell-permeable pan-caspase inhibitor zVAD.	Poly C	148-167	toll like receptor 3	Homo sapiens	183-187
33801464-6	2021	Furthermore, SARS-CoV-2 N inhibited polyinosinic: polycytidylic acid [poly(I:C)]-mediated IFN signaling at the level of Tank-binding kinase 1 (TBK1) and interfered with the association between TBK1 and interferon regulatory factor 3 (IRF3), subsequently preventing the nuclear translocation of IRF3.	Poly C	50-68	nucleocapsid phosphoprotein	Severe acute respiratory syndrome coronavirus 2	24-25
33801464-6	2021	Furthermore, SARS-CoV-2 N inhibited polyinosinic: polycytidylic acid [poly(I:C)]-mediated IFN signaling at the level of Tank-binding kinase 1 (TBK1) and interfered with the association between TBK1 and interferon regulatory factor 3 (IRF3), subsequently preventing the nuclear translocation of IRF3.	Poly C	50-68	TANK binding kinase 1	Homo sapiens	120-141
33801464-6	2021	Furthermore, SARS-CoV-2 N inhibited polyinosinic: polycytidylic acid [poly(I:C)]-mediated IFN signaling at the level of Tank-binding kinase 1 (TBK1) and interfered with the association between TBK1 and interferon regulatory factor 3 (IRF3), subsequently preventing the nuclear translocation of IRF3.	Poly C	50-68	TANK binding kinase 1	Homo sapiens	143-147
34906906-3	2022	In this context, this study addressed the relationship between the efficacy of talazoparib (TAL) as a PARPi and the activation of TLR3 or TLR9 by Polyinosinic:polycytidylic acid (Poly I:C) or CpG oligodeoxynucleotides (CpG-ODN) stimulation, respectively in triple negative breast cancer (TNBC).	Poly C	159-177	toll like receptor 3	Homo sapiens	130-134
34906906-3	2022	In this context, this study addressed the relationship between the efficacy of talazoparib (TAL) as a PARPi and the activation of TLR3 or TLR9 by Polyinosinic:polycytidylic acid (Poly I:C) or CpG oligodeoxynucleotides (CpG-ODN) stimulation, respectively in triple negative breast cancer (TNBC).	Poly C	159-177	toll like receptor 9	Homo sapiens	138-142
1690591-4	1990	The levels of these two induced activities after VIP treatment are comparable to those induced by the poly (I).poly (C), an inducer of IFN beta/alpha in mammalian cells.	Poly C	111-118	vasoactive intestinal peptide	Homo sapiens	49-52
1690591-4	1990	The levels of these two induced activities after VIP treatment are comparable to those induced by the poly (I).poly (C), an inducer of IFN beta/alpha in mammalian cells.	Poly C	111-118	interferon beta 1	Homo sapiens	135-143
34904931-2	2021	The present study has identified Poly (C) binding protein 2 (PCBP2) as a post-transcriptional suppresser for the expression of utrophin-A, the muscle-specific utrophin isoform.	Poly C	33-41	poly(rC) binding protein 2	Mus musculus	61-66
34293939-4	2021	In the first age-appropriate model for childhood arteriopathy-by administration of viral mimetic TLR3-agonist Polyinosinic:polycytidylic acid (Poly-IC) in juvenile mice-we identified a key role of the TLR3-neutrophil axis in disrupting the structural-functional integrity of the blood-brain barrier (BBB) and distorting the developing neurovascular architecture and vascular networks.	Poly C	123-141	toll-like receptor 3	Mus musculus	97-101
34293939-4	2021	In the first age-appropriate model for childhood arteriopathy-by administration of viral mimetic TLR3-agonist Polyinosinic:polycytidylic acid (Poly-IC) in juvenile mice-we identified a key role of the TLR3-neutrophil axis in disrupting the structural-functional integrity of the blood-brain barrier (BBB) and distorting the developing neurovascular architecture and vascular networks.	Poly C	123-141	toll-like receptor 3	Mus musculus	201-205
34695651-5	2021	PU.1 expression also primes the cells to develop a strong immune response against the dsRNA virus mimic polyinosinic:polycytidylic acid (poly I:C) by significantly up-regulating Interferon-beta (14.9 fold change with p-value <0.0001).	Poly C	117-135	Spi-1 proto-oncogene	Homo sapiens	0-4
34695651-5	2021	PU.1 expression also primes the cells to develop a strong immune response against the dsRNA virus mimic polyinosinic:polycytidylic acid (poly I:C) by significantly up-regulating Interferon-beta (14.9 fold change with p-value <0.0001).	Poly C	117-135	interferon beta 1	Homo sapiens	178-193
34821951-6	2021	We evaluated several TLR ligand combinations and demonstrated that polyinosinic:polycytidylic acid (poly(I:C)) and R848, ligands for TLR3 and TLR7/8, respectively, constituted the optimal combination for inducing a positive co-stimulatory profile in all BDC subsets.	Poly C	80-98	toll like receptor 3	Homo sapiens	133-137
34821951-6	2021	We evaluated several TLR ligand combinations and demonstrated that polyinosinic:polycytidylic acid (poly(I:C)) and R848, ligands for TLR3 and TLR7/8, respectively, constituted the optimal combination for inducing a positive co-stimulatory profile in all BDC subsets.	Poly C	80-98	toll like receptor 7	Homo sapiens	142-148
34755645-5	2021	Mechanistically, indoprofen potently inhibited the release of HMGB1 following stimulation by lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (poly I:C), and suppressed recombinant human HMGB1(rhHMGB1)-induced inflammatory responses.	Poly C	134-152	high mobility group box 1	Homo sapiens	62-67
34232469-0	2021	Co-administration of toll-like receptor (TLR)-3 agonist Poly I:C with different infectious bursal disease (IBD) vaccines improves IBD specific immune response in chicken.	Poly C	56-64	toll like receptor 3	Gallus gallus	21-47
34904931-2	2021	The present study has identified Poly (C) binding protein 2 (PCBP2) as a post-transcriptional suppresser for the expression of utrophin-A, the muscle-specific utrophin isoform.	Poly C	33-41	utrophin	Mus musculus	159-167
34667099-3	2021	Furthermore, the NF-kappaB signaling axis and TRIF-mediated necroptosis were also strongly reduced in response to LPS and polyinosinic:polycytidylic acid.	Poly C	135-153	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	17-26
34824158-1	2021	BACKGROUND: BO-112 is a nanoplexed form of polyinosinic:polycytidylic acid that acting on toll-like receptor 3 (TLR3), melanoma differentiation-associated protein 5 (MDA5) and protein kinase RNA-activated (PKR) elicits rejection of directly injected transplanted tumors, but has only modest efficacy against distant untreated tumors.	Poly C	56-74	toll-like receptor 3	Mus musculus	90-110
34824158-1	2021	BACKGROUND: BO-112 is a nanoplexed form of polyinosinic:polycytidylic acid that acting on toll-like receptor 3 (TLR3), melanoma differentiation-associated protein 5 (MDA5) and protein kinase RNA-activated (PKR) elicits rejection of directly injected transplanted tumors, but has only modest efficacy against distant untreated tumors.	Poly C	56-74	toll-like receptor 3	Mus musculus	112-116
34824158-1	2021	BACKGROUND: BO-112 is a nanoplexed form of polyinosinic:polycytidylic acid that acting on toll-like receptor 3 (TLR3), melanoma differentiation-associated protein 5 (MDA5) and protein kinase RNA-activated (PKR) elicits rejection of directly injected transplanted tumors, but has only modest efficacy against distant untreated tumors.	Poly C	56-74	interferon induced with helicase C domain 1	Mus musculus	119-164
34824158-1	2021	BACKGROUND: BO-112 is a nanoplexed form of polyinosinic:polycytidylic acid that acting on toll-like receptor 3 (TLR3), melanoma differentiation-associated protein 5 (MDA5) and protein kinase RNA-activated (PKR) elicits rejection of directly injected transplanted tumors, but has only modest efficacy against distant untreated tumors.	Poly C	56-74	interferon induced with helicase C domain 1	Mus musculus	166-170
34824158-1	2021	BACKGROUND: BO-112 is a nanoplexed form of polyinosinic:polycytidylic acid that acting on toll-like receptor 3 (TLR3), melanoma differentiation-associated protein 5 (MDA5) and protein kinase RNA-activated (PKR) elicits rejection of directly injected transplanted tumors, but has only modest efficacy against distant untreated tumors.	Poly C	56-74	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	176-204
34824158-1	2021	BACKGROUND: BO-112 is a nanoplexed form of polyinosinic:polycytidylic acid that acting on toll-like receptor 3 (TLR3), melanoma differentiation-associated protein 5 (MDA5) and protein kinase RNA-activated (PKR) elicits rejection of directly injected transplanted tumors, but has only modest efficacy against distant untreated tumors.	Poly C	56-74	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	206-209
34693552-5	2022	Upon challenge with the immunostimulant polyinosinic:polycytidylic acid (poly(I:C)), NK cells isolated from Hpse-/- mice displayed impaired cytotoxicity against EO771.LMB cells and reduced levels of activation markers CD69 and NKG2D.	Poly C	53-71	heparanase	Mus musculus	108-112
34693552-5	2022	Upon challenge with the immunostimulant polyinosinic:polycytidylic acid (poly(I:C)), NK cells isolated from Hpse-/- mice displayed impaired cytotoxicity against EO771.LMB cells and reduced levels of activation markers CD69 and NKG2D.	Poly C	53-71	killer cell lectin-like receptor subfamily K, member 1	Mus musculus	227-232
34667099-3	2021	Furthermore, the NF-kappaB signaling axis and TRIF-mediated necroptosis were also strongly reduced in response to LPS and polyinosinic:polycytidylic acid.	Poly C	135-153	toll-like receptor adaptor molecule 2	Mus musculus	46-50
34990938-7	2022	After challenge with Streptococcus agalactiae, lipopolysaccharides (LPS) and polyinosinic polycytidylic acid (Poly I:C), the expression level of Onddx43 mRNA was upregulated or downregulated in all of the tissues tested.	Poly C	110-118	probable ATP-dependent RNA helicase DDX43	Oreochromis niloticus	145-152
34643794-5	2022	Pro-inflammatory signaling was induced by TLR-3 agonist polyinosinic:polycytidylic acid (Poly I:C).	Poly C	69-87	toll like receptor 3	Homo sapiens	42-47
35221299-3	2022	In this study, we used Beas-2B human bronchial epithelial cells to investigate the effects of the TLR3 agonist polyinosinic:polycytidylic acid (Poly(I:C)) on airway cell migration and primary cilia (PC) formation.	Poly C	124-142	toll like receptor 3	Homo sapiens	98-102
34303791-2	2021	Polyinosinic:polycytidylic acid (PIC) is a Toll-like receptor 3 (TLR3) agonist that induces tumor cells apoptosis after activation.	Poly C	13-31	toll like receptor 3	Homo sapiens	43-63
34303791-2	2021	Polyinosinic:polycytidylic acid (PIC) is a Toll-like receptor 3 (TLR3) agonist that induces tumor cells apoptosis after activation.	Poly C	13-31	toll like receptor 3	Homo sapiens	65-69
34616125-6	2021	Cytokine array and enzymelinked immunosorbent assay analysis showed increased expression of inflammatory cytokines such as interleukin6 and granulocyte-macrophage colony-stimulating factor by polyinosinic-polycytidylic acid stimulation, with expression levels differing according to hot springs hydrochemical composition.	Poly C	205-223	interleukin 6	Homo sapiens	123-135
34616125-6	2021	Cytokine array and enzymelinked immunosorbent assay analysis showed increased expression of inflammatory cytokines such as interleukin6 and granulocyte-macrophage colony-stimulating factor by polyinosinic-polycytidylic acid stimulation, with expression levels differing according to hot springs hydrochemical composition.	Poly C	205-223	colony stimulating factor 2	Homo sapiens	140-188
34512638-8	2021	Ligation of TLR3 by polyI:C in BSMCs was associated with increased TLR3 mRNA expression, and 1,25D3 treatment significantly reduced its expression.	Poly C	20-27	toll like receptor 3	Homo sapiens	12-16
34512638-8	2021	Ligation of TLR3 by polyI:C in BSMCs was associated with increased TLR3 mRNA expression, and 1,25D3 treatment significantly reduced its expression.	Poly C	20-27	toll like receptor 3	Homo sapiens	67-71
34512638-9	2021	In addition, 1,25D3 decreased the expression of IL-6, IFN-beta1, CCL2, FN1 and COL1A1 induced by polyI:C in BSMCs.	Poly C	97-104	interleukin 6	Homo sapiens	48-52
34512638-9	2021	In addition, 1,25D3 decreased the expression of IL-6, IFN-beta1, CCL2, FN1 and COL1A1 induced by polyI:C in BSMCs.	Poly C	97-104	interferon alpha 1	Homo sapiens	54-63
34512638-9	2021	In addition, 1,25D3 decreased the expression of IL-6, IFN-beta1, CCL2, FN1 and COL1A1 induced by polyI:C in BSMCs.	Poly C	97-104	C-C motif chemokine ligand 2	Homo sapiens	65-69
34512638-9	2021	In addition, 1,25D3 decreased the expression of IL-6, IFN-beta1, CCL2, FN1 and COL1A1 induced by polyI:C in BSMCs.	Poly C	97-104	fibronectin 1	Homo sapiens	71-74
34512638-9	2021	In addition, 1,25D3 decreased the expression of IL-6, IFN-beta1, CCL2, FN1 and COL1A1 induced by polyI:C in BSMCs.	Poly C	97-104	collagen type I alpha 1 chain	Homo sapiens	79-85
34233389-1	2021	Poly(rC)-binding protein 2 (PCBP2) is an RNA-binding protein that is characterized by its ability to interact with poly(C) with high affinity in a sequence-specific manner.	Poly C	115-122	poly(rC) binding protein 2	Homo sapiens	0-26
34233389-1	2021	Poly(rC)-binding protein 2 (PCBP2) is an RNA-binding protein that is characterized by its ability to interact with poly(C) with high affinity in a sequence-specific manner.	Poly C	115-122	poly(rC) binding protein 2	Homo sapiens	28-33
34233389-1	2021	Poly(rC)-binding protein 2 (PCBP2) is an RNA-binding protein that is characterized by its ability to interact with poly(C) with high affinity in a sequence-specific manner.	Poly C	115-122	RNA binding motif single stranded interacting protein 3	Homo sapiens	41-60
35232977-8	2022	Finally, we observed that RP5-998N21.4OE can enhance IFIT2- and IFIT3-mediated immune defense responses through activation of signal transducer and activator of transcription 1 (STAT1) signaling pathway in U251 astrocytoma cells under treatment with the viral mimetic polyinosinic: polycytidylic acid (poly I:C).	Poly C	282-300	interferon induced protein with tetratricopeptide repeats 2	Homo sapiens	53-58
35163772-3	2022	The liposomal vaccine adjuvant CAF 09b contains the TLR3 agonist polyinosinic:polycytidylic acid, which induces a type I interferon (IFN-I) response and an antiviral state in the affected tissues.	Poly C	78-96	toll like receptor 3	Homo sapiens	52-56
35232977-8	2022	Finally, we observed that RP5-998N21.4OE can enhance IFIT2- and IFIT3-mediated immune defense responses through activation of signal transducer and activator of transcription 1 (STAT1) signaling pathway in U251 astrocytoma cells under treatment with the viral mimetic polyinosinic: polycytidylic acid (poly I:C).	Poly C	282-300	interferon induced protein with tetratricopeptide repeats 3	Homo sapiens	64-69
35232977-8	2022	Finally, we observed that RP5-998N21.4OE can enhance IFIT2- and IFIT3-mediated immune defense responses through activation of signal transducer and activator of transcription 1 (STAT1) signaling pathway in U251 astrocytoma cells under treatment with the viral mimetic polyinosinic: polycytidylic acid (poly I:C).	Poly C	282-300	signal transducer and activator of transcription 1	Homo sapiens	126-176
35232977-8	2022	Finally, we observed that RP5-998N21.4OE can enhance IFIT2- and IFIT3-mediated immune defense responses through activation of signal transducer and activator of transcription 1 (STAT1) signaling pathway in U251 astrocytoma cells under treatment with the viral mimetic polyinosinic: polycytidylic acid (poly I:C).	Poly C	282-300	signal transducer and activator of transcription 1	Homo sapiens	178-183
35280398-0	2022	Polyinosinic:polycytidylic acid aggravates calcipotriol-induced atopic dermatitis-like skin lesions in mice by increasing the expression of thymic stromal lymphopoietin.	Poly C	13-31	thymic stromal lymphopoietin	Mus musculus	140-168
35174347-5	2022	Our results showed that stimulation with polyinosinic:polycytidylic acids (Poly (I:C)), a synthetic agonist for TLR3 signaling, increased the mRNA expression of PPDPF in chicken fibroblasts DF-1 but not in chicken macrophage-like cells HD11.	Poly C	54-73	toll like receptor 3	Gallus gallus	112-116
35174347-5	2022	Our results showed that stimulation with polyinosinic:polycytidylic acids (Poly (I:C)), a synthetic agonist for TLR3 signaling, increased the mRNA expression of PPDPF in chicken fibroblasts DF-1 but not in chicken macrophage-like cells HD11.	Poly C	54-73	pancreatic progenitor cell differentiation and proliferation factor	Gallus gallus	161-166
34983106-5	2022	In vitro, polyinosinic:polycytidylic acid (Poly I-C) treatment markedly enhanced the production of SAA1 from AECs, which was further augmented by neutrophils; SAA1 could induce the production of interleukin (IL)-6, IL-8, and S100 calcium-binding protein A9 from AECs.	Poly C	23-41	serum amyloid A1	Homo sapiens	99-103
34983106-5	2022	In vitro, polyinosinic:polycytidylic acid (Poly I-C) treatment markedly enhanced the production of SAA1 from AECs, which was further augmented by neutrophils; SAA1 could induce the production of interleukin (IL)-6, IL-8, and S100 calcium-binding protein A9 from AECs.	Poly C	23-41	serum amyloid A1	Homo sapiens	159-163
34983106-5	2022	In vitro, polyinosinic:polycytidylic acid (Poly I-C) treatment markedly enhanced the production of SAA1 from AECs, which was further augmented by neutrophils; SAA1 could induce the production of interleukin (IL)-6, IL-8, and S100 calcium-binding protein A9 from AECs.	Poly C	23-41	interleukin 6	Homo sapiens	195-213
34983106-5	2022	In vitro, polyinosinic:polycytidylic acid (Poly I-C) treatment markedly enhanced the production of SAA1 from AECs, which was further augmented by neutrophils; SAA1 could induce the production of interleukin (IL)-6, IL-8, and S100 calcium-binding protein A9 from AECs.	Poly C	23-41	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
34983106-5	2022	In vitro, polyinosinic:polycytidylic acid (Poly I-C) treatment markedly enhanced the production of SAA1 from AECs, which was further augmented by neutrophils; SAA1 could induce the production of interleukin (IL)-6, IL-8, and S100 calcium-binding protein A9 from AECs.	Poly C	23-41	S100 calcium binding protein A9	Homo sapiens	225-256