PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24335212-5	2014	Our results indicated that phospholipase Cgamma (PLCgamma) is involved in the CB1 receptor-mediated synaptic effect of BDNF, because the BDNF effect was blocked in the presence of the broad-spectrum PLC inhibitors U-73122 and edelfosine, whereas the inactive analog U-73343 did not alter the suppressive effect of BDNF at inhibitory synapses.	U 73343	266-273	cannabinoid receptor 1 (brain)	Mus musculus	78-81
24335212-5	2014	Our results indicated that phospholipase Cgamma (PLCgamma) is involved in the CB1 receptor-mediated synaptic effect of BDNF, because the BDNF effect was blocked in the presence of the broad-spectrum PLC inhibitors U-73122 and edelfosine, whereas the inactive analog U-73343 did not alter the suppressive effect of BDNF at inhibitory synapses.	U 73343	266-273	brain derived neurotrophic factor	Mus musculus	119-123
24335212-5	2014	Our results indicated that phospholipase Cgamma (PLCgamma) is involved in the CB1 receptor-mediated synaptic effect of BDNF, because the BDNF effect was blocked in the presence of the broad-spectrum PLC inhibitors U-73122 and edelfosine, whereas the inactive analog U-73343 did not alter the suppressive effect of BDNF at inhibitory synapses.	U 73343	266-273	brain derived neurotrophic factor	Mus musculus	137-141
24335212-5	2014	Our results indicated that phospholipase Cgamma (PLCgamma) is involved in the CB1 receptor-mediated synaptic effect of BDNF, because the BDNF effect was blocked in the presence of the broad-spectrum PLC inhibitors U-73122 and edelfosine, whereas the inactive analog U-73343 did not alter the suppressive effect of BDNF at inhibitory synapses.	U 73343	266-273	brain derived neurotrophic factor	Mus musculus	137-141
18682550-5	2008	U73122 and U73343 also unexpectedly suppressed Ca(2+)-activated K(+) channels of the large-conductance type (MaxiK, BK) in a PLC-independent fashion.	U 73343	11-17	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	109-114
20803215-4	2010	Inhibiting PLC activity using the aminosteroid U73122 significantly inhibited root elongation and disrupted root morphology in a concentration-dependent manner, with the response being saturated at 5 muM, whereas the inactive analogue U73343 was ineffective.	U 73343	235-241	phospholipase C1	Arabidopsis thaliana	11-14
16122875-0	2005	Inhibitory effects of U73122 and U73343 on Ca2+ influx and pore formation induced by the activation of P2X7 nucleotide receptors in mouse microglial cell line.	U 73343	33-39	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	103-107
16122875-6	2005	In contrast, both U73122 and U73343 inhibited the sustained [Ca2+]i increase either prior or after the activation of P2X7 receptor channels by ATP and BzATP.	U 73343	29-35	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	117-130
14989758-4	2004	The reduction of Hsp70 level was specifically attributed to the inhibition of PLC, since the non-active inhibitor, U73343, had no effect on Hsp70 level.	U 73343	115-121	heat shock protein family A (Hsp70) member 4	Homo sapiens	17-22
14704368-9	2004	A PI-PLC appears to be required for phagocytosis of apoptotic cells, as the PI-PLC inhibitor Et-18-OCH3 and the PLC inhibitor U73122, but not the inactive control U73343, blocked phagocytosis without impairing adhesion.	U 73343	163-169	protein disulfide isomerase associated 3	Mus musculus	2-8
14704368-9	2004	A PI-PLC appears to be required for phagocytosis of apoptotic cells, as the PI-PLC inhibitor Et-18-OCH3 and the PLC inhibitor U73122, but not the inactive control U73343, blocked phagocytosis without impairing adhesion.	U 73343	163-169	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	5-8
15750341-6	2005	ERK phosphorylation was not affected by exposure to the Ca2+ chelator BAPTA-AM but inhibition of protein kinase C (PKC) with GF109203X, inhibition of Src kinase with PP1 (5 microM) and inhibition of phospholipase C (PLC) with U73122/U73343 (5 microM) all reduced ERK phosphorylation in response to glycated LDL.	U 73343	233-239	mitogen-activated protein kinase 1	Homo sapiens	0-3
14989758-4	2004	The reduction of Hsp70 level was specifically attributed to the inhibition of PLC, since the non-active inhibitor, U73343, had no effect on Hsp70 level.	U 73343	115-121	heparan sulfate proteoglycan 2	Homo sapiens	78-81
9316850-0	1997	The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell.	U 73343	72-78	LOC100009319	Oryctolagus cuniculus	13-28
12895647-6	2003	Furthermore, a phospholipase C (PLC) selective inhibitor, U-73122, completely blocks the phosphorylation of PKD/PKCmu by CKS-17 while a negative control U-73343 does not.	U 73343	153-160	protein kinase D1	Homo sapiens	108-111
12628492-11	2003	The close structural analogue of U-73122, U-73343, caused a minimal effect on the concentration-response curve of ET-1.	U 73343	42-49	endothelin 1	Rattus norvegicus	114-118
12091553-3	2002	We found, using whole cell or perforated patch recording from bullfrog sympathetic B neurons that ATP-induced suppression of g(M) was attenuated by the phospholipase C (PLC) inhibitor, U73122 (IC(50) approximately 0.14 microM) but not by the inactive isomer, U73343.	U 73343	259-265	heparan sulfate proteoglycan 2	Homo sapiens	169-172
11825342-8	2002	Cells challenged with MTX and rescued by subsequent addition of U73343, showed enhanced caspase-3 activity 48 hr after the initial insult, consistent with activation of the apoptotic program.	U 73343	64-70	caspase 3	Bos taurus	88-97
10675238-11	2000	Cells exposed to EGF +/- the inactive phospholipase C inhibitor U73343 demonstrated a significant increase in nucleic acid and protein.	U 73343	64-70	epidermal growth factor	Homo sapiens	17-20
10644473-8	2000	Cells exposed to 100 ng/ml EGF demonstrated an initial increase in [Ca(2+)](i) (1-5 min) which was blocked with neomycin, an inhibitor of inositol 1,4,5-trisphosphate (IP(3)) generation, and the phospholipase C (PLC) inhibitor U73122, but not U73343 (inactive control).	U 73343	243-249	epidermal growth factor	Homo sapiens	27-30
10644473-13	2000	Both indices of injury were significantly decreased when cells were pretreated with EGF +/- the inactive PLC inhibitor U73343.	U 73343	119-125	epidermal growth factor	Homo sapiens	84-87
10644473-13	2000	Both indices of injury were significantly decreased when cells were pretreated with EGF +/- the inactive PLC inhibitor U73343.	U 73343	119-125	heparan sulfate proteoglycan 2	Homo sapiens	105-108
9214686-0	1997	Human platelet activation is inhibited upstream of the activation of phospholipase A2 by U73343.	U 73343	89-95	phospholipase A2 group IB	Homo sapiens	69-85
9214686-6	1997	U73343 was a potent inhibitor of TG-evoked arachidonic acid release, but a weak inhibitor of cytosolic phospholipase A2 (cPLA2; EC 3.1.1.4) activity.	U 73343	0-6	phospholipase A2 group IVA	Homo sapiens	93-119
9214686-6	1997	U73343 was a potent inhibitor of TG-evoked arachidonic acid release, but a weak inhibitor of cytosolic phospholipase A2 (cPLA2; EC 3.1.1.4) activity.	U 73343	0-6	phospholipase A2 group IVA	Homo sapiens	121-126
9030204-3	1997	The supposed control compound U73343, was found to inhibit TxA2 formation; it therefore partially inhibited the rise in [Ca2+]i evoked by low concentrations of thrombin, by thapsigargin or by collagen.	U 73343	30-36	coagulation factor II, thrombin	Homo sapiens	160-168
9030204-4	1997	U73343 had a greater effect than aspirin on the action of collagen, indicating an action on the TxA2-independent component of the signal, via PLC gamma-U73343 lowered TxA2 production by inhibiting the activation of cPLA2, probably at a tyrosine phosphorylation step.	U 73343	0-6	heparan sulfate proteoglycan 2	Homo sapiens	142-145
9030204-4	1997	U73343 had a greater effect than aspirin on the action of collagen, indicating an action on the TxA2-independent component of the signal, via PLC gamma-U73343 lowered TxA2 production by inhibiting the activation of cPLA2, probably at a tyrosine phosphorylation step.	U 73343	0-6	phospholipase A2 group IVA	Homo sapiens	215-220
9030204-5	1997	U73343 seems to inhibit only the tyrosine kinases involved in the activation of PLC gamma and the generation of TxA2.	U 73343	0-6	heparan sulfate proteoglycan 2	Homo sapiens	80-83