PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
3404462-10	1988	The transient AHP was either greatly reduced or abolished by 5-10 mM-tetraethylammonium (TEA) and by 15-20 nM-charybdotoxin (CTX), both of which block a particular Ca2+-dependent K+ current.	Charybdotoxin	110-123	carbonic anhydrase 2	Rattus norvegicus	164-167
2481312-0	1989	Charybdotoxin inhibits proliferation and interleukin 2 production in human peripheral blood lymphocytes.	Charybdotoxin	0-13	interleukin 2	Homo sapiens	41-54
2481312-1	1989	We demonstrate that blockade of the lymphocyte voltage-gated K+ channel by charybdotoxin (CTX) inhibits lymphocyte mitogenesis.	Charybdotoxin	75-88	potassium voltage-gated channel subfamily D member 3	Homo sapiens	47-71
31644953-0	2019	L-type Ca2+ channels and charybdotoxin-sensitive Ca2+-activated K+ channels are required for reduction of GABAergic activity induced by beta2-adrenoceptor in the prefrontal cortex.	Charybdotoxin	25-38	adrenoceptor beta 2	Homo sapiens	136-154
33339256-4	2020	Competitive binding experiments revealed that the binding site of GFP-L2-AgTx2 overlaps that of charybdotoxin, kaliotoxin 1, and agitoxin 2, the known Kv1.3-channel pore blockers.	Charybdotoxin	96-109	potassium voltage-gated channel subfamily A member 3	Homo sapiens	151-156
30771259-13	2019	l-NAME, apamine, and charybdotoxin reversed the relaxation effects of PlGF on UA responses to Ang II (P < 0.05).	Charybdotoxin	21-34	placental growth factor	Homo sapiens	70-74
30771259-13	2019	l-NAME, apamine, and charybdotoxin reversed the relaxation effects of PlGF on UA responses to Ang II (P < 0.05).	Charybdotoxin	21-34	angiotensinogen	Homo sapiens	94-100
29545539-0	2018	Solution structure of extracellular loop of human beta4 subunit of BK channel and its biological implication on ChTX sensitivity.	Charybdotoxin	112-116	adaptor related protein complex 4 subunit beta 1	Homo sapiens	50-55
30349568-5	2018	Urotensin-II efficacy was significantly increased in chtx, TEA and BaCl2 treated groups, while significantly decreased in glibenclamide and clotrimazole treated groups as compared with the control group.	Charybdotoxin	53-57	urotensin 2	Rattus norvegicus	0-12
27732975-11	2016	In the cerebral arteries from the CSE knockdown rat, non-NO/PGI2-mediated responses were significantly attenuated, and the remaining responses were abolished by charybdotoxin and apamin or the CSE inhibitor propargylglycine.	Charybdotoxin	161-174	cystathionine gamma-lyase	Rattus norvegicus	34-37
27097551-4	2016	Whole-cell patch clamp recordings were performed in rat cortical neurons to evaluate CNTF-ACM"s effects upon charybdotoxin-sensitive large-conductance KCa (BK) channel currents and apamin-sensitive small-conductance KCa (SK) channel current.	Charybdotoxin	109-122	ciliary neurotrophic factor	Rattus norvegicus	85-89
28018918-7	2016	The relaxation response of colonic SM strips to stretch was attenuated by charybdotoxin (ChTX), a nonspecific BKCa blocker (P < 0.05).	Charybdotoxin	74-87	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	110-114
28018918-9	2016	Still, ChTX and iberiotoxin (IbTX, a specific BKCa blocker) attenuated the relaxation of the colonic muscle strips enduring stretch (P < 0.05).	Charybdotoxin	7-11	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	46-50
28000721-7	2016	BDL significantly promoted the charybdotoxin sensitive MaxiK current and KATP current in isolated aortic smooth muscle cells.	Charybdotoxin	31-44	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	55-60
26381170-6	2015	Whole-cell patch-clamp recordings showed that hSlo3 currents are inhibited: significantly by progesterone, Ba(2+) and quinidine; partially by Penitrem A and Charybdotoxin; and poorly by Iberiotoxin and Slotoxin.	Charybdotoxin	157-170	potassium calcium-activated channel subfamily U member 1	Homo sapiens	46-51
25128173-6	2014	In contrast, when small-conductance calcium-activated potassium (KCa) channels and intermediate- and large-conductance KCa (I/BKCa) are inhibited with apamin and charybdotoxin, NO is able to compensate for ACh-induced relaxation in control but not in diabetic vessels.	Charybdotoxin	162-175	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	126-130
25601026-3	2015	Block of KCa3.1 by application of charybdotoxin resulted in a 50% reduction in the steady-state [Ca(2+)]i, consistent with the well established role for KCa3.1-mediated hyperpolarisation in augmenting CRAC entry.	Charybdotoxin	34-47	potassium calcium-activated channel subfamily N member 4	Homo sapiens	9-15
24887687-6	2014	GLP-1(7-36)- and GLP-1(9-36)-induced relaxations were blunted significantly and to similar extends by charybdotoxin and apamin combination in control and diabetic rats.	Charybdotoxin	102-115	glucagon	Rattus norvegicus	0-5
24887687-6	2014	GLP-1(7-36)- and GLP-1(9-36)-induced relaxations were blunted significantly and to similar extends by charybdotoxin and apamin combination in control and diabetic rats.	Charybdotoxin	102-115	glucagon	Rattus norvegicus	17-22
23418650-6	2013	This effect was inhibited by muscarinic antagonist (atropine) or the co-application of charybdotoxin and apamin, which blocked intermediate- and small-conductance KCa (IKCa and SKCa) channels, or abolished in CSE-KO mice.	Charybdotoxin	87-100	cystathionase (cystathionine gamma-lyase)	Mus musculus	209-212
24858807-9	2014	Exposure to chronic hypoxia up-regulated the gene expression of the KCa2.3 channel by twofold in wild type mice and increased by 2.5-fold the relaxation evoked by the KCa2.3 and KCa3.1 channel activator NS309, whereas the acetylcholine-induced relaxation - sensitive to the combination of KCa2.3 and KCa3.1 channel blockers, apamin and charybdotoxin - was reduced by 2.5-fold in chronic hypoxic mice of either genotype.	Charybdotoxin	336-349	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	Mus musculus	68-74
24858807-9	2014	Exposure to chronic hypoxia up-regulated the gene expression of the KCa2.3 channel by twofold in wild type mice and increased by 2.5-fold the relaxation evoked by the KCa2.3 and KCa3.1 channel activator NS309, whereas the acetylcholine-induced relaxation - sensitive to the combination of KCa2.3 and KCa3.1 channel blockers, apamin and charybdotoxin - was reduced by 2.5-fold in chronic hypoxic mice of either genotype.	Charybdotoxin	336-349	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	Mus musculus	167-173
24858807-9	2014	Exposure to chronic hypoxia up-regulated the gene expression of the KCa2.3 channel by twofold in wild type mice and increased by 2.5-fold the relaxation evoked by the KCa2.3 and KCa3.1 channel activator NS309, whereas the acetylcholine-induced relaxation - sensitive to the combination of KCa2.3 and KCa3.1 channel blockers, apamin and charybdotoxin - was reduced by 2.5-fold in chronic hypoxic mice of either genotype.	Charybdotoxin	336-349	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	178-184
24858807-9	2014	Exposure to chronic hypoxia up-regulated the gene expression of the KCa2.3 channel by twofold in wild type mice and increased by 2.5-fold the relaxation evoked by the KCa2.3 and KCa3.1 channel activator NS309, whereas the acetylcholine-induced relaxation - sensitive to the combination of KCa2.3 and KCa3.1 channel blockers, apamin and charybdotoxin - was reduced by 2.5-fold in chronic hypoxic mice of either genotype.	Charybdotoxin	336-349	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	Mus musculus	167-173
23717641-10	2013	IL-2 secretion was also inhibited by the Kv1.3 inhibitors margatoxin and charybdotoxin.	Charybdotoxin	73-86	interleukin 2	Homo sapiens	0-4
24138859-4	2013	Here, the binding modes of two selected scorpion toxins, charybdotoxin (ChTx) and OSK1, to human KCa3.1 are examined in atomic detail using molecular dynamics (MD) simulations.	Charybdotoxin	57-70	potassium calcium-activated channel subfamily N member 4	Homo sapiens	97-103
24138859-4	2013	Here, the binding modes of two selected scorpion toxins, charybdotoxin (ChTx) and OSK1, to human KCa3.1 are examined in atomic detail using molecular dynamics (MD) simulations.	Charybdotoxin	72-76	potassium calcium-activated channel subfamily N member 4	Homo sapiens	97-103
24138859-7	2013	The ChTx-KCa3.1 complex predicted from biased MD is consistent with the crystal structure of ChTx bound to a voltage-gated K(+) channel.	Charybdotoxin	4-8	potassium calcium-activated channel subfamily N member 4	Homo sapiens	9-15
24137539-5	2013	We also show that human KSper is inhibited by charybdotoxin, iberiotoxin, and paxilline, while mouse KSper is insensitive to these compounds.	Charybdotoxin	46-59	cation channel, sperm associated 1	Mus musculus	24-29
23452113-6	2013	This effect of TGF-beta1 on SOCE was not inhibited by glucocorticoid dexamethasone (DXM, 100 nM), antioxidant alpha-tocopherol (100 muM), and intermediate-conductance Ca(2+)-activated K(+) channels (IKCa) inhibitor charybdotoxin (100 nM), suggesting that reactive oxygen species and IKCa channels might not mediate the effect of TGF-beta1.	Charybdotoxin	215-228	transforming growth factor, beta 1	Rattus norvegicus	15-24
23717641-10	2013	IL-2 secretion was also inhibited by the Kv1.3 inhibitors margatoxin and charybdotoxin.	Charybdotoxin	73-86	potassium voltage-gated channel subfamily A member 3	Homo sapiens	41-46
23511633-5	2013	Indeed, individually substituting these residues with histidyl or lysyl (maintaining the positive electric charge partially or fully), although decreasing BmP05 affinity, still preserved the toxin sensitivity profile of the SK3 channel (as evidenced by the lack of recognition by many other types of potassium channel-sensitive charybdotoxin).	Charybdotoxin	328-341	potassium calcium-activated channel subfamily N member 3	Homo sapiens	224-227
23407879-2	2013	The whole cell current was inhibited by the intermediate-conductance KCa3.1 inhibitors clotrimazole, TRAM-34, and charybdotoxin, unaffected by the small-conductance KCa2 family inhibitor apamin and the large-conductance KCa1.1 inhibitors paxilline and iberiotoxin, and augmented by NS309.	Charybdotoxin	114-127	potassium calcium-activated channel subfamily N member 4	Homo sapiens	69-75
23511633-6	2013	In contrast, when Arg-485 or Arg-489 of the SK3 channel was mutated to an acidic (Glu) or alcoholic (Ser) amino acid residue, the channel lost its sensitivity to BmP05 and became susceptible to the "new" blocking activity by charybdotoxin.	Charybdotoxin	225-238	potassium calcium-activated channel subfamily N member 3	Homo sapiens	44-47
21426317-10	2011	Charybdotoxin (BK(Ca), SK3.1 blocker), but not iberiotoxin (BK(Ca) blocker), inhibited responses to the PAR2 agonists in db/db.	Charybdotoxin	0-13	coagulation factor II (thrombin) receptor-like 1	Mus musculus	104-108
22490327-0	2012	Charybdotoxin and margatoxin acting on the human voltage-gated potassium channel hKv1.3 and its H399N mutant: an experimental and computational comparison.	Charybdotoxin	0-13	potassium voltage-gated channel subfamily A member 3	Homo sapiens	81-87
22217882-11	2012	In eNOS+/+ mice, the acetylcholine-induced response was primarily mediated by NO and was sensitive to iberiotoxin and the combination of apamin and charybdotoxin.	Charybdotoxin	148-161	nitric oxide synthase 3, endothelial cell	Mus musculus	3-7
21996476-1	2011	Recently, we have reported electropharmacological properties of a charybdotoxin (ChTx)- and ATP-insensitive-iberiotoxin (IbTx)-sensitive large conductance Ca+2-activated potassium (BKCa) channel in almost purified brain mitochondrial inner membrane vesicles.	Charybdotoxin	66-79	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	181-185
21996476-1	2011	Recently, we have reported electropharmacological properties of a charybdotoxin (ChTx)- and ATP-insensitive-iberiotoxin (IbTx)-sensitive large conductance Ca+2-activated potassium (BKCa) channel in almost purified brain mitochondrial inner membrane vesicles.	Charybdotoxin	81-85	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	181-185
22261055-1	2011	Using both Brownian and molecular dynamics, we replicate many of the salient features of Kv1.2, including the current-voltage-concentration profiles and the binding affinity and binding mechanisms of charybdotoxin, a scorpion venom.	Charybdotoxin	200-213	potassium voltage-gated channel subfamily A member 2	Homo sapiens	89-94
22131399-9	2011	Furthermore, the intrathecal administration of charybdotoxin, a K(Ca) channel blocker, significantly inhibited the nerve injury-induced tactile allodynia, the expression of P2X(4) receptors, and the synthesis of brain-derived neurotrophic factor in spinal microglia.	Charybdotoxin	47-60	casein kappa	Homo sapiens	64-69
22131399-9	2011	Furthermore, the intrathecal administration of charybdotoxin, a K(Ca) channel blocker, significantly inhibited the nerve injury-induced tactile allodynia, the expression of P2X(4) receptors, and the synthesis of brain-derived neurotrophic factor in spinal microglia.	Charybdotoxin	47-60	brain derived neurotrophic factor	Homo sapiens	212-245
21868633-7	2011	The channels were not observed when charybdotoxin, a peptide inhibitor of Kcnn4 channels, was added to the pipette solution.	Charybdotoxin	36-49	potassium calcium-activated channel subfamily N member 4	Rattus norvegicus	74-79
22964465-5	2012	Endothelin-1 (2 nM)-induced inhibition of NA release was neither attenuated by PLC inhibitors [U-73122 (3 muM) and ET-18-OCH(3) (3 muM)] nor by Ca(2+)-activated K(+) channel blockers [charybdotoxin (0.1 muM) (a blocker of BK type K(+) channel) and apamin (0.3 muM) (a blocker of SK type K(+) channel)].	Charybdotoxin	184-197	endothelin 1	Rattus norvegicus	0-12
21557879-4	2012	We herein report that treatment with CS-A after 60-min middle cerebral artery occlusion dose-dependently reduced the cerebral infarction with at least a 6-h efficacious time-window, which was partially blocked by the BKCa channel blocker charybdotoxin (CTX).	Charybdotoxin	238-251	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	217-221
22217882-3	2012	Apamin and the combination of apamin and iberiotoxin or apamin and charybdotoxin induced a transient endothelium-dependent contraction of small mesenteric arteries from both eNOS-/- and +/+ mice.	Charybdotoxin	67-80	nitric oxide synthase 3, endothelial cell	Mus musculus	174-178
21615723-6	2011	The PAR2-induced PVAT-dependent relaxation (SLIGRL-NH(2) ) persisted in the presence of apamin plus charybdotoxin, 4-aminopyridine and glibenclamide, but was blocked by catalase, implicating a role for H(2) O(2) .	Charybdotoxin	100-113	coagulation factor II (thrombin) receptor-like 1	Mus musculus	4-8
21877740-0	2011	Charybdotoxin unbinding from the mKv1.3 potassium channel: a combined computational and experimental study.	Charybdotoxin	0-13	potassium voltage-gated channel, shaker-related subfamily, member 3	Mus musculus	33-39
21877740-1	2011	Charybdotoxin, belonging to the group of so-called scorpion toxins, is a short peptide able to block many voltage-gated potassium channels, such as mKv1.3, with high affinity.	Charybdotoxin	0-13	potassium voltage-gated channel, shaker-related subfamily, member 3	Mus musculus	148-154
21877740-2	2011	We use a reliable homology model based on the high-resolution crystal structure of the 94% sequence identical homologue Kv1.2 for charybdotoxin docking followed by molecular dynamics simulations to investigate the mechanism and energetics of unbinding, tracing the behavior of the channel protein and charybdotoxin during umbrella-sampling simulations as charybdotoxin is moved away from the binding site.	Charybdotoxin	130-143	potassium voltage-gated channel subfamily A member 2	Homo sapiens	120-125
21877740-2	2011	We use a reliable homology model based on the high-resolution crystal structure of the 94% sequence identical homologue Kv1.2 for charybdotoxin docking followed by molecular dynamics simulations to investigate the mechanism and energetics of unbinding, tracing the behavior of the channel protein and charybdotoxin during umbrella-sampling simulations as charybdotoxin is moved away from the binding site.	Charybdotoxin	301-314	potassium voltage-gated channel subfamily A member 2	Homo sapiens	120-125
21877740-2	2011	We use a reliable homology model based on the high-resolution crystal structure of the 94% sequence identical homologue Kv1.2 for charybdotoxin docking followed by molecular dynamics simulations to investigate the mechanism and energetics of unbinding, tracing the behavior of the channel protein and charybdotoxin during umbrella-sampling simulations as charybdotoxin is moved away from the binding site.	Charybdotoxin	301-314	potassium voltage-gated channel subfamily A member 2	Homo sapiens	120-125
21506954-12	2011	TRAM-34 inhibited EFS-evoked arteriolar dilatation by 50% whereas charybdotoxin, a blocker of K(Ca)3.1 and the large-conductance K(Ca) channel, K(Ca)1.1, inhibited dilatation by 82%.	Charybdotoxin	66-79	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	94-102
21506954-12	2011	TRAM-34 inhibited EFS-evoked arteriolar dilatation by 50% whereas charybdotoxin, a blocker of K(Ca)3.1 and the large-conductance K(Ca) channel, K(Ca)1.1, inhibited dilatation by 82%.	Charybdotoxin	66-79	carbonic anhydrase 11	Mus musculus	144-152
20488163-9	2010	These effects were mimicked by Margatoxin, a specific Kv1.3 inhibitor, and Charybdotoxin, which blocks both Kv1.3 and Ca(2+)-activated K(+) channels (K(Ca)3.1).	Charybdotoxin	75-88	potassium voltage-gated channel subfamily A member 3	Homo sapiens	108-113
21397040-9	2011	DPP-4 inhibition induced relaxation was completely abolished by a combination of L-NMMA, charybdotoxin and apamin.	Charybdotoxin	89-102	dipeptidyl peptidase 4	Homo sapiens	0-5
21356332-4	2011	Blockade of MaxiK channels with charybdotoxin (100 nM) in both older (P16-P18) and younger (P2-P3) animals resulted in no significant change in AP activity, but increased nerve conduction speed in the older animals.	Charybdotoxin	32-45	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	12-17
21813671-8	2011	In young 3xTg and wild mice, we confirmed spike broadening by Abeta(1-42), which was again mimicked and occluded by charybdotoxin and blocked by ECS.	Charybdotoxin	116-129	amyloid beta (A4) precursor protein	Mus musculus	62-67
20870805-7	2010	The enhancing effect of EPO was reduced by l-NMMA but not by catalase in CSA and was reduced by l-NMMA+catalase in CA, where the greater inhibitory effects were noted with l-NMMA+catalase, l-NMMA+iberiotoxin, L-NMMA+apamin+charybdotoxin, or wortmannin.	Charybdotoxin	223-236	erythropoietin	Canis lupus familiaris	24-27
20870805-7	2010	The enhancing effect of EPO was reduced by l-NMMA but not by catalase in CSA and was reduced by l-NMMA+catalase in CA, where the greater inhibitory effects were noted with l-NMMA+catalase, l-NMMA+iberiotoxin, L-NMMA+apamin+charybdotoxin, or wortmannin.	Charybdotoxin	223-236	catalase	Canis lupus familiaris	103-111
20870805-7	2010	The enhancing effect of EPO was reduced by l-NMMA but not by catalase in CSA and was reduced by l-NMMA+catalase in CA, where the greater inhibitory effects were noted with l-NMMA+catalase, l-NMMA+iberiotoxin, L-NMMA+apamin+charybdotoxin, or wortmannin.	Charybdotoxin	223-236	catalase	Canis lupus familiaris	103-111
17872452-6	2007	Ruthenium red and the combination of charybdotoxin and apamin prevented the latter effect, suggesting that Trp channel activation increases Ca(2+) influx and prolongs the activation of Ca(2+)-dependent K(+) (K(Ca)) channels.	Charybdotoxin	37-50	casein kappa	Homo sapiens	208-213
20735417-4	2010	KEY RESULTS: In a GPR55-dependent, GDPbetaS and U73122-sensitive manner, LPI induced rapid and transient intracellular Ca(2+) release that was associated with activation of charybdotoxin-sensitive, large conductance, Ca(2+)-activated, K(+) channels (BK(Ca)) and temporary membrane hyperpolarization.	Charybdotoxin	173-186	G protein-coupled receptor 55	Homo sapiens	18-23
18559348-4	2008	In addition, the tyrosine insert mutant (in100Y) showed 56% inhibition, with a K(d) = 17 nm, suggesting that the hbeta4 lacks an external ChTX-binding site (Tyr-100).	Charybdotoxin	138-142	potassium calcium-activated channel subfamily M regulatory beta subunit 4	Homo sapiens	113-119
18559348-5	2008	We also found that mSlo had an internal binding site (Tyr-294) in the alpha subunits that could "permanently" block 15% of mSlo+hbeta4 currents in the presence of 100 nm ChTX.	Charybdotoxin	170-174	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	Mus musculus	19-23
18559348-5	2008	We also found that mSlo had an internal binding site (Tyr-294) in the alpha subunits that could "permanently" block 15% of mSlo+hbeta4 currents in the presence of 100 nm ChTX.	Charybdotoxin	170-174	potassium calcium-activated channel subfamily M regulatory beta subunit 4	Homo sapiens	128-134
18519030-3	2008	IL-1beta (30-100 ng/ml) inhibited the mean amplitude of the NMDA-induced outward currents that were mediated by charybdotoxin (ChTX)-sensitive Ca(2+)-activated K(+) (K(Ca)) channels.	Charybdotoxin	112-125	interleukin 1 beta	Homo sapiens	0-8
18519030-3	2008	IL-1beta (30-100 ng/ml) inhibited the mean amplitude of the NMDA-induced outward currents that were mediated by charybdotoxin (ChTX)-sensitive Ca(2+)-activated K(+) (K(Ca)) channels.	Charybdotoxin	112-125	casein kappa	Homo sapiens	166-171
18519030-3	2008	IL-1beta (30-100 ng/ml) inhibited the mean amplitude of the NMDA-induced outward currents that were mediated by charybdotoxin (ChTX)-sensitive Ca(2+)-activated K(+) (K(Ca)) channels.	Charybdotoxin	127-131	interleukin 1 beta	Homo sapiens	0-8
18519030-3	2008	IL-1beta (30-100 ng/ml) inhibited the mean amplitude of the NMDA-induced outward currents that were mediated by charybdotoxin (ChTX)-sensitive Ca(2+)-activated K(+) (K(Ca)) channels.	Charybdotoxin	127-131	casein kappa	Homo sapiens	166-171
18204477-13	2008	CONCLUSIONS AND IMPLICATIONS: Palmatine attenuated Ca(2+)-activated Cl(-) secretion through inhibiting basolateral charybdotoxin-sensitive, SK4 K(+) channels, whereas it inhibited cAMP-activated Cl(-) secretion by inhibiting apical CFTR Cl(-) channels and basolateral chromanol 293B-sensitive, KvLQT1 K(+) channels.	Charybdotoxin	115-128	potassium calcium-activated channel subfamily N member 4	Rattus norvegicus	140-143
18299396-6	2008	To overcome this limitation, we engineered a charybdotoxin (CTX)-sensitive Kv4.2 channel, which enabled us to obtain the first measurements of Kv4.2 gating currents after blocking K+ conduction with CTX (Dougherty and Covarrubias.	Charybdotoxin	45-58	potassium voltage-gated channel subfamily D member 2	Homo sapiens	75-80
18299396-6	2008	To overcome this limitation, we engineered a charybdotoxin (CTX)-sensitive Kv4.2 channel, which enabled us to obtain the first measurements of Kv4.2 gating currents after blocking K+ conduction with CTX (Dougherty and Covarrubias.	Charybdotoxin	45-58	potassium voltage-gated channel subfamily D member 2	Homo sapiens	143-148
20335378-5	2010	Compared with controls, coronary arteries from dex-exposed lambs demonstrated enhanced vasoconstriction to endothelin-1 and ACh that was abolished by endothelial removal or preincubation with the nitric oxide synthase inhibitor L-NNA, membrane-permeable superoxide dismutase + catalase, or apamin + charybdotoxin, but not indomethacin.	Charybdotoxin	299-312	EDN1	Ovis aries	107-119
20332617-6	2010	This LPS-induced current exhibited KCNQ1 K+ channel characteristics, i.e. inhibition by quinidine, chromanol293B and low dose of HMR1556 (IC50<1 microM) and insensitive to TEA and charybdotoxin.	Charybdotoxin	183-196	potassium voltage-gated channel, subfamily Q, member 1	Mus musculus	35-40
19934650-4	2010	Slo3 is resistant to block by the standard Slo1 blockers, iberiotoxin, charybdotoxin and extracellular TEA.	Charybdotoxin	71-84	potassium calcium-activated channel subfamily U member 1	Homo sapiens	0-4
19168436-5	2009	The hyperpolarization was inhibited by an anti-TRPC1 blocking antibody T1E3 and 2 BK(Ca) channel blockers, charybdotoxin and iberiotoxin.	Charybdotoxin	107-120	transient receptor potential cation channel subfamily C member 1	Homo sapiens	47-52
18188587-10	2008	The hyperpolarizing response was abolished by charybdotoxin, a selective blocker for SK4/IKCa1.	Charybdotoxin	46-59	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	85-88
18188587-10	2008	The hyperpolarizing response was abolished by charybdotoxin, a selective blocker for SK4/IKCa1.	Charybdotoxin	46-59	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	89-94
17340126-6	2007	The conducted hyperpolarizations and relaxations to BK were unaffected by L-NOARG, but were abolished by apamin and charybdotoxin.	Charybdotoxin	116-129	kininogen 1	Homo sapiens	52-54
17459950-4	2007	Importantly, apamin and charybdotoxin (ChTx)/ triarylmethane (TRAM)-34, selective blockers SK(Ca) and IK(Ca) channels, respectively, abolished both stimulated NO synthesis and membrane hyperpolarization and decreased evoked Ca(2+) transients.	Charybdotoxin	24-37	translocation associated membrane protein 1	Homo sapiens	62-66
17610869-7	2007	Furthermore, the intermediate- and large-conductance Ca2+-activated K+ (IKCa-BKCa) channel blocker charybdotoxin significantly reduced CO- and CORM-2-induced relaxations in jejunal tissue; this same effect was observed with the BKCa channel blocker iberiotoxin.	Charybdotoxin	99-112	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	Mus musculus	77-81
17610869-7	2007	Furthermore, the intermediate- and large-conductance Ca2+-activated K+ (IKCa-BKCa) channel blocker charybdotoxin significantly reduced CO- and CORM-2-induced relaxations in jejunal tissue; this same effect was observed with the BKCa channel blocker iberiotoxin.	Charybdotoxin	99-112	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	Mus musculus	228-232
17095754-4	2007	Although blocking the presumably apically located K(+) channel KCNQ1 with chromanol 293b reduced both the forskolin- and carbachol-induced cell shrinkage, inhibition of Ca(2+)-sensitive K(+) channels with charybdotoxin strongly inhibited the cell volume decrease after carbachol, but not after forskolin stimulation.	Charybdotoxin	205-218	potassium voltage-gated channel subfamily KQT member 1	Oryctolagus cuniculus	63-68
17285630-8	2007	Suppression of K(+) channels (BK channels) with 25 nM charybdotoxin inhibited high-Ca(2+) (o)-stimulated CXCL10 release.	Charybdotoxin	54-67	chemokine (C-X-C motif) ligand 10	Mus musculus	105-111
16396931-5	2006	Hypoxia increased cell proliferation, but the K(Ca) channel blockers apamin and charybdotoxin slowed down cell growth, particularly under hypoxic conditions.	Charybdotoxin	80-93	casein kappa	Homo sapiens	46-51
17147779-8	2006	We used charybdotoxin to pharmacologically separate the individual components of IKfast to show that increased Eve specifically down regulates the Slowpoke (a BK Ca2+-gated potassium channel), but not Shal, component of this current.	Charybdotoxin	8-21	even skipped	Drosophila melanogaster	111-114
16809411-11	2006	In contrast, HLMC migration towards the chemokine CXCL10, the chemoattractant stem cell factor, and the supernatants from tumour necrosis factor alpha stimulated asthmatic ASM was markedly inhibited with both the non-selective K(Ca)3.1 blocker charybdotoxin and the highly specific K(Ca)3.1 blocker TRAM-34 in a dose dependent manner.	Charybdotoxin	244-257	C-X-C motif chemokine ligand 10	Homo sapiens	50-56
16455686-7	2006	Cholecystokinin reduced the amplitude of the after-hyperpolarization of the action potentials, and application of paxilline or charybdotoxin considerably reduced CCK-mediated modulation of sIPSC frequency, suggesting that the effects of CCK are related to the inhibition of Ca(2+)-activated K(+) currents (I(K(Ca))).	Charybdotoxin	127-140	cholecystokinin	Rattus norvegicus	162-165
16302263-3	2006	The selective K(ATP) and large conductance Ca(2+) activated K(+) (BK(Ca)) channel inhibitors, glibenclamide and charybdotoxin, respectively were used to inhibit responses to PKG activators.	Charybdotoxin	112-125	protein kinase cGMP-dependent 1	Homo sapiens	174-177
16410000-3	2006	The remaining dilatation was inhibited by the potassium channel blockers, charybdotoxin and apamin, providing direct evidence that angiotensin II induces EDHF-mediated dilatation in cerebral arteries.	Charybdotoxin	74-87	angiotensinogen	Rattus norvegicus	131-145
15548728-6	2004	In the absence of L-NNA, responses to ADP were markedly reduced by charybdotoxin plus apamin [inhibitors of Ca2+-dependent K+ channels and responses mediated by endothelium-derived hyperpolarizing factor (EDHF)] in both WT and eNOS-/- mice.	Charybdotoxin	67-80	nitric oxide synthase 3, endothelial cell	Mus musculus	227-231
16151435-5	2005	This increased BKCa current activity was abolished by charybdotoxin (100 nM) and iberiotoxin (100 nM).	Charybdotoxin	54-67	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	15-19
15662023-8	2005	bFGF- and VEGF-induced EC proliferation was suppressed by charybdotoxin, clotrimazole, or the selective IKCa1 blocker 1-[(2-chlorophenyl)diphenylmethyl]-1H-pyrazole (TRAM-34), whereas inhibition of BK(Ca)/Slo by iberiotoxin was ineffective.	Charybdotoxin	58-71	fibroblast growth factor 2	Homo sapiens	0-5
15662023-8	2005	bFGF- and VEGF-induced EC proliferation was suppressed by charybdotoxin, clotrimazole, or the selective IKCa1 blocker 1-[(2-chlorophenyl)diphenylmethyl]-1H-pyrazole (TRAM-34), whereas inhibition of BK(Ca)/Slo by iberiotoxin was ineffective.	Charybdotoxin	58-71	vascular endothelial growth factor A	Homo sapiens	10-14
15775782-6	2005	Intravenous infusion of 50 mug/kg each of apamin and charybdotoxin (ChTX), a combination that is known to block Ca-activated K channels or the endothelium-derived hyperpolarization process, attenuated the decrease in MAP evoked by ghrelin in both control and NOS-inhibited rats.	Charybdotoxin	53-66	ghrelin and obestatin prepropeptide	Rattus norvegicus	231-238
15775782-6	2005	Intravenous infusion of 50 mug/kg each of apamin and charybdotoxin (ChTX), a combination that is known to block Ca-activated K channels or the endothelium-derived hyperpolarization process, attenuated the decrease in MAP evoked by ghrelin in both control and NOS-inhibited rats.	Charybdotoxin	68-72	ghrelin and obestatin prepropeptide	Rattus norvegicus	231-238
15893312-3	2005	The effect of E2 was sensitive to Iberiotoxin, Charybdotoxin and TEA and can be elicited in the presence of the anti-estrogen ICI 182780 or be mimicked by the membrane impermeant form E2/BSA.	Charybdotoxin	47-60	cystatin 12, pseudogene	Homo sapiens	184-190
15721872-9	2005	Urocortin-induced relaxations were also inhibited by treatment with putative K(+) channel blockers, such as tetraethylammonium (TEA(+)), charybdotoxin (CTX), and iberiotoxin (IBX).	Charybdotoxin	137-150	urocortin	Homo sapiens	0-9
15654262-11	2005	4-Aminopyridine (4-AP) as well as charybdotoxin reduced angiotensin II-induced relaxation.	Charybdotoxin	34-47	angiotensinogen	Rattus norvegicus	56-70
15680257-4	2005	Charybdotoxin, a blocker of large-conductance Ca(2+)-activated K+ (BK(Ca)) channels, also augmented ischemic injury, whereas AM 92016, a blocker of delayed rectifier K+ channels, and dequalinium, a blocker of small-conductance Ca(2+)-activated K+ channels, had no significant effect.	Charybdotoxin	0-13	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	67-73
15237098-3	2004	Both in segments perfused at a flow rate of 2.5 ml min(-1) and in rings mounted in a myograph, bradykinin and acetylcholine each induced vasodilator responses that were mediated jointly by EDHF and nitric oxide, as revealed by their respective blocking agents, apamin/charybdotoxin, and L-NAME.	Charybdotoxin	268-281	kininogen 1	Bos taurus	95-105
15361764-5	2004	L-NAME, charybdotoxin + apamin, KCl, and ouabain shifted the bradykinin concentration-response curve (CRC) approximately 10-fold to the right.	Charybdotoxin	8-21	kininogen 1	Homo sapiens	61-71
15361764-7	2004	Full blockade of bradykinin was obtained when combining L-NAME with charybdotoxin + apamin, KCl or ouabain + BaCl2.	Charybdotoxin	68-81	kininogen 1	Homo sapiens	17-27
15208030-0	2004	Block of maurotoxin and charybdotoxin on human intermediate-conductance calcium-activated potassium channels (hIKCa1).	Charybdotoxin	24-37	potassium calcium-activated channel subfamily N member 4	Homo sapiens	110-116
15208030-1	2004	Using human intermediate-conductance calcium-activated potassium (hIKCa1) channels as a model we aimed to characterize structural differences between maurotoxin (MTX) and charybdotoxin (CTX) and to gain new insights into the molecular determinants that define the interaction of these pore-blocking peptides with hIKCa1 channel.	Charybdotoxin	171-184	potassium calcium-activated channel subfamily N member 4	Homo sapiens	66-72
14602578-5	2004	In outside-out macropatches, activity of native SK4/IK1-like channels, defined as a charybdotoxin (100 nM)-blockable current in the presence of TEA (10 mM) in the bathing solution, ran down unless both ATP and Mg2+ were present in the pipette solution.	Charybdotoxin	84-97	potassium calcium-activated channel subfamily N member 4	Rattus norvegicus	48-51
12947021-6	2004	The hIK-1-mediated ATP release was inhibited by a hIK-1 blocker (charybdotoxin), and an Na(+)-K(+)-2Cl(-) cotransport blocker (bumetanide) without interruption by GdCl(3), an inhibitor of stretch-activated nonselective cation (SA) channels, or glybenclamide, a blocker of the cystic fibrosis transmembrane conductance regulator (CFTR).	Charybdotoxin	65-78	potassium calcium-activated channel subfamily N member 4	Homo sapiens	4-9
12947021-6	2004	The hIK-1-mediated ATP release was inhibited by a hIK-1 blocker (charybdotoxin), and an Na(+)-K(+)-2Cl(-) cotransport blocker (bumetanide) without interruption by GdCl(3), an inhibitor of stretch-activated nonselective cation (SA) channels, or glybenclamide, a blocker of the cystic fibrosis transmembrane conductance regulator (CFTR).	Charybdotoxin	65-78	potassium calcium-activated channel subfamily N member 4	Homo sapiens	50-55
14602578-5	2004	In outside-out macropatches, activity of native SK4/IK1-like channels, defined as a charybdotoxin (100 nM)-blockable current in the presence of TEA (10 mM) in the bathing solution, ran down unless both ATP and Mg2+ were present in the pipette solution.	Charybdotoxin	84-97	potassium calcium-activated channel subfamily N member 4	Rattus norvegicus	52-55
12970102-10	2003	Combined administration of apamin and charybdotoxin, but not each of them, specifically abolished the hypotension, increased GMBF and decreased GMVR caused by the PAR-2 agonists.	Charybdotoxin	38-51	F2R like trypsin receptor 1	Rattus norvegicus	163-168
14691197-5	2004	In contrast, complete blockade of bradykinin-induced relaxation was obtained when we combined the nonselective BK(Ca) and intermediate-conductance (IK(Ca)) Ca2+-dependent K+ channel blocker charybdotoxin and apamin with hydroxocobalamin.	Charybdotoxin	190-203	kininogen 1	Homo sapiens	34-44
14610244-7	2004	The fluoranthene-induced modulations of these anion transporters were counteracted by charybdotoxin (ChTx, a hIK-1 channel blocker).	Charybdotoxin	86-99	IKAROS family zinc finger 1	Homo sapiens	109-114
14610244-7	2004	The fluoranthene-induced modulations of these anion transporters were counteracted by charybdotoxin (ChTx, a hIK-1 channel blocker).	Charybdotoxin	101-105	IKAROS family zinc finger 1	Homo sapiens	109-114
14729096-0	2004	Inhibition of the antigen-induced activation of RBL-2H3 cells by charybdotoxin and cetiedil.	Charybdotoxin	65-78	RB transcriptional corepressor like 2	Rattus norvegicus	48-53
14729096-3	2004	Charybdotoxin and cetiedil dose-dependently inhibited beta-hexosaminidase release with IC(50) values of 133 nM and 84 microM, respectively.	Charybdotoxin	0-13	O-GlcNAcase	Rattus norvegicus	54-73
14691049-9	2004	Charybdotoxin (ChTX), which blocks large-conductance calcium-activated potassium channels (BK(Ca)) and intermediate-conductance calcium-activated potassium channels (IK(Ca)), plus apamin, which blocks small-conductance calcium-activated potassium channels (SK(Ca)), but not iberiotoxin, which only blocks BK(Ca), attenuated endothelium-dependent relaxation of aortae from daidzein or 17beta-oestradiol-treated rats.	Charybdotoxin	0-13	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	91-97
14691049-9	2004	Charybdotoxin (ChTX), which blocks large-conductance calcium-activated potassium channels (BK(Ca)) and intermediate-conductance calcium-activated potassium channels (IK(Ca)), plus apamin, which blocks small-conductance calcium-activated potassium channels (SK(Ca)), but not iberiotoxin, which only blocks BK(Ca), attenuated endothelium-dependent relaxation of aortae from daidzein or 17beta-oestradiol-treated rats.	Charybdotoxin	15-19	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	91-97
12809950-4	2003	The blocker of Ca(2+)-sensitive K(+) channels charybdotoxin (10(-7) M) increased the contraction to vasopressin in coronary arteries of diabetic females, but not in the other cases (diabetic males and normoglycemic females or males).	Charybdotoxin	46-59	arginine vasopressin	Rattus norvegicus	100-111
12928406-4	2003	The Ca2+ channel blockers, nickel and econazole, and the K+ channel blockers, tetraethylammonium chloride, apamin, and charybdotoxin, inhibit the granulysin-induced increase in intracellular Ca2+ ([Ca2+](i)), the decrease in intracellular K+, and apoptosis.	Charybdotoxin	119-132	granulysin	Homo sapiens	146-156
12842920-5	2003	Blockade of calcium-sensitive voltage-gated K+ channels (BKCa) with charybdotoxin or iberiotoxin inhibited 89% and 82% of the current, respectively.	Charybdotoxin	68-81	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	57-61
12606780-2	2003	Vasorelaxation by abn-cbd is endothelium-dependent, pertussis toxin-sensitive, and is inhibited by the BK(Ca) channel inhibitor charybdotoxin, but not by the nitric-oxide synthase inhibitor N(omega)-nitro-L-arginine methyl ester or by the vanilloid VR1 receptor antagonist capsazepine.	Charybdotoxin	128-141	vault RNA 1-1	Homo sapiens	249-252
12562560-0	2003	ChTX induces oscillatory contraction in guinea pig trachea: role of cyclooxygenase-2 and PGE2.	Charybdotoxin	0-4	prostaglandin G/H synthase 2	Cavia porcellus	68-84
12562560-12	2003	These results suggest that ChTX specifically activates COX-2 and stimulates PGE(2) production and that ChTX-induced oscillatory contraction in guinea pig trachea is mediated by activation of EP(1) receptor.	Charybdotoxin	27-31	cytochrome c oxidase subunit II	Cavia porcellus	55-60
12798445-5	2003	The potassium channel blocker charybdotoxin (10(-7) M) reduced the relaxation to urocortin of renal arteries from normoglycemic males and females.	Charybdotoxin	30-43	urocortin	Rattus norvegicus	81-90
12482897-7	2002	The ability of leptin to modulate this activity requires activation of BK, but not K(ATP), channels as the effects of leptin were mimicked by the BK channel activator NS-1619, and inhibited by the BK channel inhibitors, iberiotoxin and charybdotoxin.	Charybdotoxin	236-249	leptin	Rattus norvegicus	15-21
12598413-11	2003	In phenylephrine-preconstricted CA, acetylcholine-induced NO and prostacyclin-independent vasodilation was almost completely blocked by ChTX, CLT, TRAM-34, or TRAM-39 in combination with the SK3-blocker apamin.	Charybdotoxin	136-140	potassium calcium-activated channel subfamily N member 3	Rattus norvegicus	191-194
12532279-7	2003	Addition of ChTX (50 nM), IbTX (100 nM), Stk (100 nM) or CLT (1 microM) inhibited the HGF/SF-stimulated MDCK II cell migration.	Charybdotoxin	12-16	hepatocyte growth factor	Canis lupus familiaris	86-92
12558995-4	2003	The patch-clamp recording found that martentoxin at the applied dose of 100 nm could strongly block large-conductance Ca2+-activated K+ (BKCa) currents in adrenal medulla chromaffin cells, and BKCa currents blocked by martentoxin could be fully recovered within 30 seconds after washing, which is at least 10 times faster than recovery after charybdotoxin.	Charybdotoxin	342-355	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	193-197
14622925-8	2003	The data imply that failure of glycine receptors provokes enhanced bursting behaviour of respiratory neurones, whilst the additional blockade of BKCa channels by charybdotoxin or with pentobarbital abolishes the respiratory rhythm.	Charybdotoxin	162-175	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	Mus musculus	145-149
12482897-7	2002	The ability of leptin to modulate this activity requires activation of BK, but not K(ATP), channels as the effects of leptin were mimicked by the BK channel activator NS-1619, and inhibited by the BK channel inhibitors, iberiotoxin and charybdotoxin.	Charybdotoxin	236-249	leptin	Rattus norvegicus	118-124
12466245-14	2002	Substance P, bradykinin (100 nM) and 1-EBIO evoked charybdotoxin-sensitive, iberiotoxin-insensitive whole-cell perforated-patch currents.	Charybdotoxin	51-64	tachykinin precursor 1	Homo sapiens	0-11
12466245-14	2002	Substance P, bradykinin (100 nM) and 1-EBIO evoked charybdotoxin-sensitive, iberiotoxin-insensitive whole-cell perforated-patch currents.	Charybdotoxin	51-64	kininogen 1	Homo sapiens	13-23
12163354-0	2002	Charybdotoxin-sensitive small conductance K(Ca) channel activated by bradykinin and substance P in endothelial cells.	Charybdotoxin	0-13	casein kappa	Homo sapiens	42-47
12381678-4	2002	EDHF-mediated relaxation was abolished by a depolarizing concentration of KCl (40 mM) as well as by a combination of charybdotoxin and apamin (each 100 nM), two inhibitors of calcium-dependent K+ (K+(Ca)) channels.	Charybdotoxin	117-130	casein kappa	Homo sapiens	197-203
12381678-5	2002	Charybdotoxin and apamin also reduced the bradykinin-induced, EDHF-mediated hyperpolarization of smooth muscle cells from 13.7+/-1.3 mV to 5.7+/-1.2 mV.	Charybdotoxin	0-13	kininogen 1	Homo sapiens	42-52
12359636-11	2002	The K(+) channel blocker apamin (100 nM), combined with charybdotoxin (100 nM), produced a small reduction in the maximum response to bradykinin but they abolished the response to bradykinin when ODQ, L-NAME or hydroxocobalamin were present.	Charybdotoxin	56-69	kininogen 1	Bos taurus	134-144
12359636-11	2002	The K(+) channel blocker apamin (100 nM), combined with charybdotoxin (100 nM), produced a small reduction in the maximum response to bradykinin but they abolished the response to bradykinin when ODQ, L-NAME or hydroxocobalamin were present.	Charybdotoxin	56-69	kininogen 1	Bos taurus	180-190
12163354-0	2002	Charybdotoxin-sensitive small conductance K(Ca) channel activated by bradykinin and substance P in endothelial cells.	Charybdotoxin	0-13	kininogen 1	Homo sapiens	69-79
12163354-0	2002	Charybdotoxin-sensitive small conductance K(Ca) channel activated by bradykinin and substance P in endothelial cells.	Charybdotoxin	0-13	tachykinin precursor 1	Homo sapiens	84-95
12163354-9	2002	Charybdotoxin inhibited by 75% the bradykinin-induced current and by 80% the substance P-induced current.	Charybdotoxin	0-13	kininogen 1	Homo sapiens	35-45
12163354-9	2002	Charybdotoxin inhibited by 75% the bradykinin-induced current and by 80% the substance P-induced current.	Charybdotoxin	0-13	tachykinin precursor 1	Homo sapiens	77-88
12163354-10	2002	Charybdotoxin plus iberiotoxin (50 nM each) inhibited by 97% the bradykinin-response.	Charybdotoxin	0-13	kininogen 1	Homo sapiens	65-75
11682450-4	2001	In arteries contracted with prostaglandin F(2 alpha) (2.5 - 10 microM), relaxation evoked by ACh (0.01 - 3 microM) was abolished by a combination of charybdotoxin (ChTX, 0.1 microM) plus apamin (Apa, 0.1 microM) and was inhibited by 68+/-6% (n=6) by 4-aminopyridine (4-AP, 5 mM).	Charybdotoxin	149-162	glutamyl aminopeptidase	Rattus norvegicus	195-198
12016269-6	2002	Adenoviral-mediated overexpression of the CYP isoform, CYP2J2, in SMCs also inhibited serum- and PDGF-induced SMC migration by 32% and 26%, respectively; both effects of which were reversed by the CYP inhibitors SKF525A or clotrimazole, but not by the K(Ca) channel blocker, charybdotoxin, or the cyclooxygenase inhibitor, diclofenac.	Charybdotoxin	275-288	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	42-45
12016269-6	2002	Adenoviral-mediated overexpression of the CYP isoform, CYP2J2, in SMCs also inhibited serum- and PDGF-induced SMC migration by 32% and 26%, respectively; both effects of which were reversed by the CYP inhibitors SKF525A or clotrimazole, but not by the K(Ca) channel blocker, charybdotoxin, or the cyclooxygenase inhibitor, diclofenac.	Charybdotoxin	275-288	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	55-61
12016269-6	2002	Adenoviral-mediated overexpression of the CYP isoform, CYP2J2, in SMCs also inhibited serum- and PDGF-induced SMC migration by 32% and 26%, respectively; both effects of which were reversed by the CYP inhibitors SKF525A or clotrimazole, but not by the K(Ca) channel blocker, charybdotoxin, or the cyclooxygenase inhibitor, diclofenac.	Charybdotoxin	275-288	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	55-58
11967954-8	2002	TEA (5 mM), charybdotoxin (50 nM), and iberiotoxin (30 nM) inhibited the effect of ACh (or ATP) on the outward current, whereas apamin (100 nM) had no effect.	Charybdotoxin	12-25	acyl-CoA thioesterase 12	Rattus norvegicus	83-86
12172639-9	2002	The contribution of KCa channels could be excluded, as 500 nM charybdotoxin, which completely blocked KCa, had no effect on proliferation.	Charybdotoxin	62-75	casein kappa	Homo sapiens	102-105
12051720-7	2002	Ca(2+)-dependent K channel (KCa) blockers, apamin with charybdotoxin, inhibited the relaxation by LIF.	Charybdotoxin	55-68	LIF, interleukin 6 family cytokine	Rattus norvegicus	98-101
11490317-8	2001	In types I and II cells at voltages positive to 30 mV, maxi K+ channel (Ca2+ activated large conductance K+ channel or BK) blockade with iberiotoxin or charybdotoxin reduced outward currents by approximately 40% to 80% at 80 mV.	Charybdotoxin	152-165	calcium-activated potassium channel subunit alpha-1	Oryctolagus cuniculus	55-61
11762799-14	2001	The increased IK by SIN-1 was inhibited by charybdotoxin (CTX) about 70%.	Charybdotoxin	43-56	MAPK associated protein 1	Homo sapiens	20-25
11454664-6	2001	The combination of ChTx (50 nM) and apamin (30 nM) attenuated the L-NOARG-insensitive component of ACh-induced relaxation (E(max): 15.2+/-10.5%, P<0.002, n=6) although these arteries retained the ability to relax in response to 100 microM SIN-1 (E(max) 127.6+/-13.0%, n=3).	Charybdotoxin	19-23	MAPK associated protein 1	Homo sapiens	242-247
11437954-0	2001	Phage randomization in a charybdotoxin scaffold leads to CD4-mimetic recognition motifs that bind HIV-1 envelope through non-aromatic sequences.	Charybdotoxin	25-38	CD4 molecule	Homo sapiens	57-60
11437954-3	2001	We describe here the display of the charybdotoxin scaffold on the filamentous phage fUSE5, its use to construct a beta-turn library, and miniprotein sequences identified through library panning with immobilized Env gp120.	Charybdotoxin	36-49	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	215-220
11136696-9	2001	Bradykinin-induced dilation declined more with CbTX+AP than with L-NMMA (-66% versus -46%, P:=0.03) and was fully blocked by their combination.	Charybdotoxin	47-51	kininogen 1	Canis lupus familiaris	0-10
11279071-4	2001	This increase in t-PA expression correlated with a 4-fold induction in t-PA gene transcription and a 3-fold increase in t-PA fibrinolytic activity and was blocked by the CYP inhibitor, SKF525A, but not by the calcium-activated potassium channel blocker, charybdotoxin, indicating a mechanism that does not involve endothelial cell hyperpolarization.	Charybdotoxin	254-267	plasminogen activator, tissue type	Homo sapiens	17-21
11306529-9	2001	Charybdotoxin 10(-8) mol/L impaired both FID (15+/-3% versus 75+/-12%, P<0.05) and hyperpolarization (-32+/-2 mV [from -28+/-2 mV after endothelin-1] versus -42+/-2 mV [-27+/-2 mV], P<0.05).	Charybdotoxin	0-13	endothelin 1	Homo sapiens	139-151
11245596-8	2001	The respiratory burst was markedly inhibited by blockers of SK2 (apamin) and SK4 channels (clotrimazole and charybdotoxin), and to a lesser extent, by the potent Kv1.3 blocker agitoxin-2.	Charybdotoxin	108-121	potassium calcium-activated channel subfamily N member 4	Rattus norvegicus	77-80
11250874-9	2001	In 300 nM U46619-precontracted arteries, pretreatment with either 100 nM charybdotoxin or 100 nM iberiotoxin or 10 nM felodipine significantly (P<0.05) attenuated the CGRP-induced reduction in both [Ca(2+)](i) and tension.	Charybdotoxin	73-86	calcitonin-related polypeptide alpha	Rattus norvegicus	170-174
11250874-12	2001	In resting coronary arteries, only pretreatment with the combination of 1 microM glibenclamide and 100 nM charybdotoxin attenuated the CGRP-induced decrease in the [Ca(2+)](i) and tension, suggesting a different mechanism of action for CGRP in resting coronary arteries.	Charybdotoxin	106-119	calcitonin-related polypeptide alpha	Rattus norvegicus	135-139
11250874-12	2001	In resting coronary arteries, only pretreatment with the combination of 1 microM glibenclamide and 100 nM charybdotoxin attenuated the CGRP-induced decrease in the [Ca(2+)](i) and tension, suggesting a different mechanism of action for CGRP in resting coronary arteries.	Charybdotoxin	106-119	calcitonin-related polypeptide alpha	Rattus norvegicus	236-240
11282120-8	2001	Charybdotoxin produced an upward and leftward shift of the concentration-response curve for vasopressin.	Charybdotoxin	0-13	arginine vasopressin	Rattus norvegicus	92-103
11284444-2	2001	Here we report that in NIH3T3 and C3H10T1/2 mouse fibroblasts S1P activates a Ca2+-dependent, voltage-independent K+ current (EC50-value 113 nM) that is blocked by the K+ channel blockers charybdotoxin, margatoxin, and iberiotoxin.	Charybdotoxin	188-201	sphingosine-1-phosphate receptor 1	Mus musculus	62-65
11294244-5	2001	The BK channel was inhibited reversibly by external tetraethylammonium (TEA) ions, charybdotoxin, and quinine and was resistant to block by 4-aminopyridine and apamin.	Charybdotoxin	83-96	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	4-14
11053215-4	2000	Since our previous results suggest that VIP induces NANC relaxation via activation of charybdotoxin (ChTx, a blocker of large conductance Ca(2+)-activated K(+) channel)-sensitive K(+) channels with concomitant slow hyperpolarization in the muscle cells, we next studied whether ChTx-sensitive component and slow hyperpolarization changes with age.	Charybdotoxin	86-99	vasoactive intestinal peptide	Rattus norvegicus	40-43
11053215-4	2000	Since our previous results suggest that VIP induces NANC relaxation via activation of charybdotoxin (ChTx, a blocker of large conductance Ca(2+)-activated K(+) channel)-sensitive K(+) channels with concomitant slow hyperpolarization in the muscle cells, we next studied whether ChTx-sensitive component and slow hyperpolarization changes with age.	Charybdotoxin	101-105	vasoactive intestinal peptide	Rattus norvegicus	40-43
11053215-4	2000	Since our previous results suggest that VIP induces NANC relaxation via activation of charybdotoxin (ChTx, a blocker of large conductance Ca(2+)-activated K(+) channel)-sensitive K(+) channels with concomitant slow hyperpolarization in the muscle cells, we next studied whether ChTx-sensitive component and slow hyperpolarization changes with age.	Charybdotoxin	278-282	vasoactive intestinal peptide	Rattus norvegicus	40-43
10912465-9	2000	Tetraethylammonium, charybdotoxin, and iberiotoxin partially decreased the BK-induced responses.	Charybdotoxin	20-33	kininogen 1	Homo sapiens	75-77
10873674-10	2000	Leptin normally relaxed arterial rings during superfusion of K channel blockers, including 3 x 10(-5) mol/l of glibenclamide, 1 x 10(-6) of mol/l apamin, and 5 x 10(-7) mol/l of charybdotoxin.	Charybdotoxin	178-191	leptin	Homo sapiens	0-6
11082118-9	2000	Charybdotoxin (0.4 mg kg(-1)) plus apamin (0.2 mg kg(-1)) significantly attenuated the depressor response to PAF (1 microg kg(-1)) (n=5) without affecting the blood pressure change due to SNP (1 mg kg(-1)) (n=3).	Charybdotoxin	0-13	PCNA clamp associated factor	Rattus norvegicus	109-112
10912465-10	2000	Apamin alone did not affect the relaxation by BK; however, in combination with charybdotoxin it almost completely abolished the BK-induced relaxation and hyperpolarization.	Charybdotoxin	79-92	kininogen 1	Homo sapiens	128-130
10790158-5	2000	Whole-cell voltage-clamp experiments showed that the KO2 current in PC12 cells is inhibited by charybdotoxin, a blocker of Kv1.2 channels.	Charybdotoxin	95-108	potassium channel, voltage gated shaker related subfamily A, member 2 L homeolog	Xenopus laevis	123-128
10792058-0	2000	A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin.	Charybdotoxin	114-127	potassium calcium-activated channel subfamily M regulatory beta subunit 4	Homo sapiens	25-31
10792058-3	2000	The pore blockers charybdotoxin (CTx) and iberiotoxin (IbTx), at nanomolar concentrations, have been invaluable in unraveling MaxiK channel physiological role in vertebrates.	Charybdotoxin	18-31	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	126-131
9730877-20	1998	Pharmacomechanical measurements made on epithelium-denuded rat bronchus showed that 100 nM charybdotoxin decreased the sensitivity of bronchial smooth muscle to SIN-1-induced relaxations.	Charybdotoxin	91-104	MAPK associated protein 1	Homo sapiens	161-166
10625664-4	2000	Initial docking of charybdotoxin was undertaken with both models, and the accuracy of these docking configurations was tested by mutant cycle analyses, establishing that charybdotoxin has a similar docking configuration in the external vestibules of IKCa1 and Kv1.3.	Charybdotoxin	170-183	potassium calcium-activated channel subfamily N member 4	Homo sapiens	250-255
10625664-4	2000	Initial docking of charybdotoxin was undertaken with both models, and the accuracy of these docking configurations was tested by mutant cycle analyses, establishing that charybdotoxin has a similar docking configuration in the external vestibules of IKCa1 and Kv1.3.	Charybdotoxin	170-183	potassium voltage-gated channel subfamily A member 3	Homo sapiens	260-265
10694213-0	2000	Involvement of cyclic AMP - PKA pathway in VIP-induced, charybdotoxin-sensitive relaxation of longitudinal muscle of the distal colon of Wistar-ST rats.	Charybdotoxin	56-69	vasoactive intestinal peptide	Rattus norvegicus	43-46
10694213-1	2000	The intracellular mechanism of vasoactive intestinal peptide (VIP)-induced, charybdotoxin (ChTx)-sensitive relaxation of longitudinal muscle of the distal colon of Wistar-ST rats was studied.	Charybdotoxin	76-89	vasoactive intestinal peptide	Rattus norvegicus	62-65
10694213-1	2000	The intracellular mechanism of vasoactive intestinal peptide (VIP)-induced, charybdotoxin (ChTx)-sensitive relaxation of longitudinal muscle of the distal colon of Wistar-ST rats was studied.	Charybdotoxin	91-95	vasoactive intestinal peptide	Rattus norvegicus	62-65
10398854-7	1999	The LTD4 (cysLT1) receptor antagonist L660,711(MK-571) blocks the activation of the charybdotoxin-sensitive but not the charybdotoxin-insensitive K+ efflux.	Charybdotoxin	84-97	cysteinyl leukotriene receptor 1	Mus musculus	10-16
10455250-3	1999	Competition experiments with charybdotoxin, known to interact with external residues of Kv1.3, showed no interaction with verapamil.	Charybdotoxin	29-42	potassium voltage-gated channel subfamily A member 3	Homo sapiens	88-93
9914284-3	1999	Charybdotoxin, a specific blocker of voltage-sensitive calcium-activated K+ channels (IC), caused a decrease in outward currents comparable with that caused by blocking calcium influx and occluded the neurotensin-induced decrease in outward currents.	Charybdotoxin	0-13	neurotensin	Rattus norvegicus	201-212
10612692-5	2000	Charybdotoxin as well as paxilline, well known blockers of MaxiK channels, were able to reduce current through MaxiK channels in our cell preparation.	Charybdotoxin	0-13	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	59-64
10612692-5	2000	Charybdotoxin as well as paxilline, well known blockers of MaxiK channels, were able to reduce current through MaxiK channels in our cell preparation.	Charybdotoxin	0-13	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	111-116
10665815-0	2000	A point mutation in the maxi-K clone dSlo forms a high affinity site for charybdotoxin.	Charybdotoxin	73-86	slowpoke	Drosophila melanogaster	37-41
10612582-2	1999	Parallel combinatorial synthesis of the resultant substituted phenyl-stilbenes on solid phase, followed by 125I Charybdotoxin (125I ChTx) screening, yielded 12 Kv1.3 channel blockers with modest activity.	Charybdotoxin	112-125	potassium voltage-gated channel subfamily A member 3	Homo sapiens	160-165
10612582-2	1999	Parallel combinatorial synthesis of the resultant substituted phenyl-stilbenes on solid phase, followed by 125I Charybdotoxin (125I ChTx) screening, yielded 12 Kv1.3 channel blockers with modest activity.	Charybdotoxin	132-136	potassium voltage-gated channel subfamily A member 3	Homo sapiens	160-165
10568794-3	1999	Whole cell patch-clamp electrophysiology was used to determine K(0.5) values for FIK block by the structurally related peptides charybdotoxin (ChTX) (7 nm) and iberiotoxin (IbTX) (536 nm), and a new unrelated FIK inhibitor, Stichodactyla toxin (StK) (85 nm).	Charybdotoxin	128-141	ZFP90 zinc finger protein	Homo sapiens	81-84
10568794-3	1999	Whole cell patch-clamp electrophysiology was used to determine K(0.5) values for FIK block by the structurally related peptides charybdotoxin (ChTX) (7 nm) and iberiotoxin (IbTX) (536 nm), and a new unrelated FIK inhibitor, Stichodactyla toxin (StK) (85 nm).	Charybdotoxin	143-147	ZFP90 zinc finger protein	Homo sapiens	81-84
10568794-6	1999	ChTX, StK, and IbTX also evoked MRF4-dependent transcription as measured by muscle acetylcholine receptor channel functional expression; but they did not evoke subsequent multinucleated fiber formation or myosin heavy chain expression, suggesting a role for FIK in early, rather than late, myogenic events.	Charybdotoxin	0-4	myogenic factor 6	Homo sapiens	32-36
10568794-7	1999	Thus despite structural differences, ChTX, IbTX, and StK have common effects on cell growth and differentiation reflecting their common FIK blocking action.	Charybdotoxin	37-41	ZFP90 zinc finger protein	Homo sapiens	136-139
10516156-3	1999	K(Ca) current was active at positive potentials and was blocked by tetraethylammonium (TEA), iberiotoxin, and charybdotoxin but was insensitive to 4-AP.	Charybdotoxin	110-123	casein kappa	Homo sapiens	0-5
10556499-6	1999	The effect of YC-1 was potentiated by zaprinast (10 microM), but inhibited by ODQ (50 microM) or charybdotoxin (0.2 microM).	Charybdotoxin	97-110	glutathione S-transferase alpha 1	Rattus norvegicus	14-18
9526059-9	1998	A selective Ca2+-activated potassium channel blocker charybdotoxin (CTX) significantly reduced relaxations to DEA-NONOate resistant to ODQ, supporting the idea that in cerebral arteries nitric oxide may activate potassium channels independently of cyclic GMP.	Charybdotoxin	53-66	5'-nucleotidase, cytosolic II	Homo sapiens	255-258
9612301-2	1998	Using the whole cell patch-clamp technique in rat intrapulmonary arterial smooth muscle cells, we found that ET-1 and the voltage-dependent K+ (Kv)-channel antagonist 4-aminopyridine, but not the Ca(2+)-activated K(+)-channel antagonist charybdotoxin (ChTX), caused membrane depolarization.	Charybdotoxin	237-250	endothelin 1	Rattus norvegicus	109-113
9612301-2	1998	Using the whole cell patch-clamp technique in rat intrapulmonary arterial smooth muscle cells, we found that ET-1 and the voltage-dependent K+ (Kv)-channel antagonist 4-aminopyridine, but not the Ca(2+)-activated K(+)-channel antagonist charybdotoxin (ChTX), caused membrane depolarization.	Charybdotoxin	252-256	endothelin 1	Rattus norvegicus	109-113
9612301-3	1998	In the presence of 100 nM ChTX, ET-1 (10(-10) to 10(-7) M) caused a concentration-dependent inhibition of K+ current (56.2 +/- 3.8% at 10(-7) M) and increased the rate of current inactivation.	Charybdotoxin	26-30	endothelin 1	Rattus norvegicus	32-36
9746905-2	1998	Exposure to A beta fragment 25-35 (20 microM) or 1-42 (20 microM) enhanced the delayed rectifier K+ current IK, shifting its activation voltage relationship toward hyperpolarized levels and increasing maximal conductance, but did not affect the transient K+ current IA or charybdotoxin-sensitive BK current.	Charybdotoxin	272-285	amyloid beta precursor protein	Homo sapiens	12-18
9692786-13	1998	The NO donor 3-morpholino-sydnonimine (SIN-1) induced a concentration-dependent relaxation, which was unaffected by charybdotoxin plus apamin, but abolished by the selective soluble guanylate cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline-1-one (ODQ, 10 microM).	Charybdotoxin	116-129	MAPK associated protein 1	Homo sapiens	39-44
9676714-4	1998	Relaxations to CNP were significantly less in arteries from male compared with female pigs and were significantly attenuated by charybdotoxin and glibenclamide in both sexes.	Charybdotoxin	128-141	natriuretic peptide C	Sus scrofa	15-18
9490871-11	1998	Sensitivity to charybdotoxin and margatoxin indicated that this K+ current was due to the activation of Kv1.3 channels.	Charybdotoxin	15-28	potassium voltage-gated channel subfamily A member 3	Homo sapiens	104-109
9484860-11	1998	The vasodilatation elicited by 8-Br-cyclic GMP (100 microM) was also reduced by TEA (3 mM) and ChTX (150 nM).	Charybdotoxin	95-99	5'-nucleotidase, cytosolic II	Homo sapiens	43-46
9215697-9	1997	The actions of neuropeptide Y on [Ca2+]i transients provoked by 20 and 50 mM KCI, 1 mM tetraethylammonium, (-)BAY K8644 and charybdotoxin were mimicked by 8-bromo-cGMP.	Charybdotoxin	124-137	pyroglutamylated RFamide peptide	Rattus norvegicus	15-27
9407042-6	1997	Patch-clamp recordings of hKCa4-transfected HEK 293 cells reveal a large voltage-independent, inwardly rectifying potassium current that is blocked by externally applied tetraethylammonium (Kd = 30 +/- 7 mM), charybdotoxin (Kd = 10 +/- 1 nM), and clotrimazole (Kd = 387 +/- 34 nM), but is resistant to apamin, iberiotoxin, kaliotoxin, scyllatoxin (Kd > 1 microM), and margatoxin (Kd > 100 nM).	Charybdotoxin	209-222	potassium calcium-activated channel subfamily N member 4	Homo sapiens	26-31
9550424-5	1997	Moreover, UTP-induced calcium increase is sufficient to activate a charybdotoxin-sensitive Ca2+-dependent outward K+ channel (K(Ca)).	Charybdotoxin	67-80	casein kappa	Homo sapiens	126-131
9421231-6	1997	Charybdotoxin, a selective blocker of Ca2+-dependent K+ channels (maxi-K) present in MG-63 cells, stimulated 1,25(OH)2D3-induced osteocalcin synthesis about 2-fold (p < 0.005) after either 30, 60, or 120 minutes of treatment.	Charybdotoxin	0-13	bone gamma-carboxyglutamate protein	Homo sapiens	129-140
9231761-12	1997	The ET-1 activated large-conductance Ca2+-dependent K+ (BK(Ca)) channels were blocked by 20 mM tetraethylammonium but were insensitive to the K+ channel blockers apamin (1 microM), charybdotoxin (200 nM), or iberiotoxin (200 nM).	Charybdotoxin	181-194	endothelin 1	Rattus norvegicus	4-8
9326665-8	1997	hIK1 currents were reversibly blocked by charybdotoxin (Ki = 2.5 nM) and clotrimazole (Ki = 24.8 nM) but were minimally affected by apamin (100 nM), iberiotoxin (50 nM), or ketoconazole (10 microM).	Charybdotoxin	41-54	potassium calcium-activated channel subfamily N member 4	Homo sapiens	0-4
9313944-22	1997	Charybdotoxin (CbTx) was significantly less potent than the dendrotoxins and had mixed actions in the CA1 region (n = 3).	Charybdotoxin	0-13	carbonic anhydrase 1	Rattus norvegicus	102-105
9313944-22	1997	Charybdotoxin (CbTx) was significantly less potent than the dendrotoxins and had mixed actions in the CA1 region (n = 3).	Charybdotoxin	15-19	carbonic anhydrase 1	Rattus norvegicus	102-105
9307224-7	1997	We conclude that one molecule of beta-endorphin or naloxone, but not both at the same time, bind to an area near the charybdotoxin/tetraethylammonium binding locus of Jurkat potassium channels.	Charybdotoxin	117-130	proopiomelanocortin	Homo sapiens	33-47
9306275-3	1997	It was found that a high concentration of charybdotoxin (100 nM, CTX), which blocks both voltage-gated (K(V)) and Ca(2+)-activated (K(Ca)) potassium channels in these cells, depolarizes Vm of lymphocytes only partially.	Charybdotoxin	42-55	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	65-68
9268324-6	1997	Addition of the SK channel blocker charybdotoxin to growth factor-containing culture medium overcame basic fibroblast growth factor-induced negative regulation of MRF4, as evidenced by induction of inward rectifier potassium and acetylcholine receptor channel expression identical to that observed in mitogen-withdrawn cells.	Charybdotoxin	35-48	myogenic factor 6	Mus musculus	163-167
9277350-12	1997	Charybdotoxin inhibited both the 1-EBIO- and Ca(2+)-induced 86Rb+ uptakes with similar affinities (Ki values of 0.57 +/- 0.07 and 0.47 +/- 0.08 nM, respectively), suggesting 1-EBIO and Ca2+ activate the same channel (KCa) in this assay.	Charybdotoxin	0-13	casein kappa	Homo sapiens	217-220
9263910-18	1997	Charybdotoxin (0.1 microM) and 4-aminopyridine (0.5 mM) strongly enhanced the depolarization and contraction caused by NPY (0.1 microM), and nifedipine (1 microM) prevented the enhanced responses to NPY in the presence of charybdotoxin.	Charybdotoxin	0-13	neuropeptide Y	Rattus norvegicus	119-122
9263910-18	1997	Charybdotoxin (0.1 microM) and 4-aminopyridine (0.5 mM) strongly enhanced the depolarization and contraction caused by NPY (0.1 microM), and nifedipine (1 microM) prevented the enhanced responses to NPY in the presence of charybdotoxin.	Charybdotoxin	0-13	neuropeptide Y	Rattus norvegicus	199-202
9263910-18	1997	Charybdotoxin (0.1 microM) and 4-aminopyridine (0.5 mM) strongly enhanced the depolarization and contraction caused by NPY (0.1 microM), and nifedipine (1 microM) prevented the enhanced responses to NPY in the presence of charybdotoxin.	Charybdotoxin	222-235	neuropeptide Y	Rattus norvegicus	119-122
9222556-9	1997	The VIP-induced decreases in the [Ca2+]i and force were attenuated by K+ channel blockers such as tetrabutylammonium (TBA: non-selective K+ channel blocker), charybdotoxin (large conductance Ca(2+)-activated K+ channel blocker), and 4-aminopyridine (4-AP: voltage-dependent K+ channel blocker).	Charybdotoxin	158-171	vasoactive intestinal peptide	Homo sapiens	4-7
9142852-3	1997	Chronic hypoxia depolarized resting membrane potential (Em) and reduced the activity of a charybdotoxin (CTX)- and iberiotoxin-sensitive, Ca2+-dependent K+ channel (KCa).	Charybdotoxin	90-103	casein kappa	Homo sapiens	153-163
9146898-2	1997	In the rat hepatic artery, the acetylcholine-induced relaxation mediated by endothelium-derived hyperpolarizing factor (EDHF) is abolished by a combination of apamin and charybdotoxin, inhibitors of small (SKCa) and large (BKCa) conductance calcium-sensitive potassium (K)-channels, respectively, but not by each toxin alone.	Charybdotoxin	170-183	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	223-227
9142852-3	1997	Chronic hypoxia depolarized resting membrane potential (Em) and reduced the activity of a charybdotoxin (CTX)- and iberiotoxin-sensitive, Ca2+-dependent K+ channel (KCa).	Charybdotoxin	90-103	casein kappa	Homo sapiens	165-168
8945908-8	1996	During contraction to either phenylephrine or prostaglandin F2 alpha, relaxations to CNP were inhibited by HS-142-1, methylene blue, TEA, and charybdotoxin, but not by L-NMMA, glibenclamide, or apamin.	Charybdotoxin	142-155	natriuretic peptide C	Canis lupus familiaris	85-88
8982501-16	1996	Exposure of intact arterial segments to charybdotoxin and apamin, in the presence of NO synthase blockers, also significantly inhibited SIN-1-evoked relaxation, reducing the maximum response by around 80% (n = 4; P < 0.01).	Charybdotoxin	40-53	MAPK associated protein 1	Homo sapiens	136-141
8982501-22	1996	In contrast, when basal NO synthesis is inhibited, SIN-1 appears to cause full relaxation by both the activation of a charybdotoxin-sensitive pathway and the stimulation of soluble guanylyl cyclase.	Charybdotoxin	118-131	MAPK associated protein 1	Homo sapiens	51-56
9124454-6	1997	Furthermore, 4-aminopyridine (4-AP, 5-10 mM), which blocks voltage-gated K+ channels (K(V)), and charybdotoxin (200 nM), which blocks Ca2+-activated K+ channels (K(Ca)), both significantly inhibited NO- and SNP-induced PA relaxation.	Charybdotoxin	97-110	casein kappa	Homo sapiens	149-160
8982501-9	1996	Exposure of endothelium-intact arterial segments to the potassium channel blocker charybdotoxin (50 nM; 10 min), significantly inhibited SIN-1-evoked relaxation, reducing the maximum response by around 90% (n = 5; P < 0.01).	Charybdotoxin	82-95	MAPK associated protein 1	Homo sapiens	137-142
8982501-11	1996	However, in the presence of NO synthase blockers and L-arginine (300 microM) together, charybdotoxin did significantly inhibit SIN-1-evoked relaxation to a similar extent as intact tissues (maximum response induced by around 80%; n = 4; P < 0.01).	Charybdotoxin	87-100	MAPK associated protein 1	Homo sapiens	127-132
8957259-0	1996	Effects of charybdotoxin on K+ channel (KV1.2) deactivation and inactivation kinetics.	Charybdotoxin	11-24	potassium voltage-gated channel subfamily A member 2	Homo sapiens	40-45
8904634-0	1996	VIP- and PACAP-mediated nonadrenergic, noncholinergic inhibition in longitudinal muscle of rat distal colon: involvement of activation of charybdotoxin- and apamin-sensitive K+ channels.	Charybdotoxin	138-151	vasoactive intestinal peptide	Rattus norvegicus	0-3
8904634-0	1996	VIP- and PACAP-mediated nonadrenergic, noncholinergic inhibition in longitudinal muscle of rat distal colon: involvement of activation of charybdotoxin- and apamin-sensitive K+ channels.	Charybdotoxin	138-151	adenylate cyclase activating polypeptide 1	Rattus norvegicus	9-14
8904634-17	1996	Charybdotoxin, but not apamin significantly inhibited the VIP-induced relaxation VIP10-28, but not PACAP6-38 selectively inhibited the VIP-induced relaxation.	Charybdotoxin	0-13	vasoactive intestinal peptide	Rattus norvegicus	58-61
8904634-17	1996	Charybdotoxin, but not apamin significantly inhibited the VIP-induced relaxation VIP10-28, but not PACAP6-38 selectively inhibited the VIP-induced relaxation.	Charybdotoxin	0-13	vasoactive intestinal peptide	Rattus norvegicus	81-84
8904634-20	1996	Apamin and to a lesser extent, charybdotoxin, inhibited the PACAP-induced relaxation.	Charybdotoxin	31-44	adenylate cyclase activating polypeptide 1	Rattus norvegicus	60-65
8904634-30	1996	From these findings it is suggested that VIP and PACAP are involved in NANC inhibitory responses of longitudinal muscle of the rat distal colon via activation of charybdotoxin- and apamin-sensitive K+ channels, respectively.	Charybdotoxin	162-175	vasoactive intestinal peptide	Rattus norvegicus	41-44
8904634-30	1996	From these findings it is suggested that VIP and PACAP are involved in NANC inhibitory responses of longitudinal muscle of the rat distal colon via activation of charybdotoxin- and apamin-sensitive K+ channels, respectively.	Charybdotoxin	162-175	adenylate cyclase activating polypeptide 1	Rattus norvegicus	49-54
8769767-5	1996	Vasodilation and increase in cAMP production evoked by CGRP were inhibited not only by glibenclamide (ATP-sensitive K+ channel blocker) but also by charybdotoxin (large-conductance Ca(2+)-activated K+ channel blocker), but this was not the case for the isoproterenol-induced vasodilation and cAMP production.	Charybdotoxin	148-161	calcitonin-related polypeptide alpha	Rattus norvegicus	55-59
8799889-12	1996	VIP (1 microM) increased charybdotoxin-insensitive outward currents.	Charybdotoxin	25-38	vasoactive intestinal peptide	Canis lupus familiaris	0-3
8799889-15	1996	VIP increased reversibly the open probability, mean open time and mean burst duration of 4-AP-sensitive, charybdotoxin-insensitive K+ channels (KDR1).	Charybdotoxin	105-118	vasoactive intestinal peptide	Canis lupus familiaris	0-3
8734907-3	1996	The PrP-null group differed in having lower input resistances, a lack of the late AHP and of a charybdotoxin-sensitive summated AHP.	Charybdotoxin	95-108	proline rich protein HaeIII subfamily 1	Mus musculus	4-7
9053774-9	1996	The functional role of BK channels in GT1-7 cells was evaluated by measuring the effect of charybdotoxin (100 nM) on basal [Ca2+]i and GnRH secretion, as well as on the [Ca2+]i and GnRH secretory responses to gamma-aminobutyric acid (GABA, 100 mu M), an excitatory neurotransmitter in this system.	Charybdotoxin	91-104	gonadotropin releasing hormone 1	Mus musculus	135-139
9139123-6	1996	ISK was at most weakly voltage-dependent, with reduced conductance at large positive potentials, and was inhibited by ChTX and weakly by TEA+, Cs+, and Ba2+, but not 4-AP or apamin.	Charybdotoxin	118-122	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	0-3
8867101-5	1996	The large conductance Ca(2+)-activated K(+)-channel blocker, charybdotoxin, antagonized the endothelin-1- and the endothelin-3-induced relaxation to the same extent.	Charybdotoxin	61-74	endothelin-1	Cavia porcellus	92-104
8867101-5	1996	The large conductance Ca(2+)-activated K(+)-channel blocker, charybdotoxin, antagonized the endothelin-1- and the endothelin-3-induced relaxation to the same extent.	Charybdotoxin	61-74	endothelin-3	Cavia porcellus	114-126
8871136-5	1996	The effects of cromakalim were antagonized by glibenclamide 10(-5) M, whereas the effects of SCA40 were inhibited by tetraethylammonium (TEA 10(-2) M) and charybdotoxin (3 x 10(-8) M), but this inhibitory effect of TEA was reversed by nifedipine (10(-6) M).	Charybdotoxin	155-168	coiled-coil domain containing 88C	Homo sapiens	93-98
7585889-8	1995	The mitogenic response to an expression of transforming Ha-ras was inhibited by the Ca(2+)-channel blockers not, however, by charybdotoxin.	Charybdotoxin	125-138	Harvey rat sarcoma virus oncogene	Mus musculus	56-62
7673227-5	1995	Dendrotoxin (DTX) and charybdotoxin (CTX), antagonists of Kv1.1 and Kv1.3 channels, respectively, decreased thymocyte yields in organ culture without affecting thymocyte viability.	Charybdotoxin	22-35	potassium voltage-gated channel, shaker-related subfamily, member 1	Mus musculus	58-63
7673227-5	1995	Dendrotoxin (DTX) and charybdotoxin (CTX), antagonists of Kv1.1 and Kv1.3 channels, respectively, decreased thymocyte yields in organ culture without affecting thymocyte viability.	Charybdotoxin	22-35	potassium voltage-gated channel, shaker-related subfamily, member 3	Mus musculus	68-73
7788870-4	1995	Conversely, with charybdotoxin (ChTX, 100 nmol/L) and niflumic acid (100 mumol/L) present to inhibit IK(Ca) and ICl(Ca), Ang II and caffeine only caused inhibition of IK(dr).	Charybdotoxin	17-30	ANG	Canis lupus familiaris	121-124
7476991-2	1995	We find that angiotensin II (Ang II) inhibits this charybdotoxin-sensitive current.	Charybdotoxin	51-64	angiotensinogen	Rattus norvegicus	13-27
7476991-2	1995	We find that angiotensin II (Ang II) inhibits this charybdotoxin-sensitive current.	Charybdotoxin	51-64	angiotensinogen	Rattus norvegicus	29-35
7788870-4	1995	Conversely, with charybdotoxin (ChTX, 100 nmol/L) and niflumic acid (100 mumol/L) present to inhibit IK(Ca) and ICl(Ca), Ang II and caffeine only caused inhibition of IK(dr).	Charybdotoxin	32-36	ANG	Canis lupus familiaris	121-124
8360176-4	1993	Like ChTX, MgTX blocks the n-type current of human T-lymphocytes (Kv1.3 channel), but compared to ChTX, is 20-fold more potent (half-block at approximately 50 pM), has a slower dissociation rate, and has no effect on calcium-activated channels.	Charybdotoxin	5-9	potassium voltage-gated channel subfamily A member 3	Homo sapiens	66-71
7534990-8	1995	A subthreshold dose of charybdotoxin potentiated AVP secretion to submaximal stimulation with endothelin-3 that was prevented only by concomitant blockade of calcium influx and intracellular mobilization.	Charybdotoxin	23-36	endothelin 3	Rattus norvegicus	94-106
7840222-6	1995	The KCa antagonists charybdotoxin, iberiotoxin, and tetraethylammonium decreased sensitivity to SNAP and SIN-1 2- to 11-fold in MPA, LPA, and Tr, with variable shifts in Ao and CA.	Charybdotoxin	20-33	casein kappa	Homo sapiens	4-7
7840222-6	1995	The KCa antagonists charybdotoxin, iberiotoxin, and tetraethylammonium decreased sensitivity to SNAP and SIN-1 2- to 11-fold in MPA, LPA, and Tr, with variable shifts in Ao and CA.	Charybdotoxin	20-33	MAPK associated protein 1	Homo sapiens	105-110
7712010-11	1995	Charybdotoxin (100 nM) increased tracheal tone, antagonized SCA40 (approximately 4 fold) and antagonized isoprenaline (approximately 3 fold).	Charybdotoxin	0-13	coiled-coil domain containing 88C	Homo sapiens	60-65
7712010-12	1995	Nifedipine (1 microM) prevented the rise in tissue tone and the antagonism of SCA40 and isoprenaline induced by charybdotoxin.	Charybdotoxin	112-125	coiled-coil domain containing 88C	Homo sapiens	78-83
8587335-5	1995	The large conductance Ca(2+)-activated K(+)-channel blocker charybdotoxin antagonized ET-1- and ET-3-induced relaxations.	Charybdotoxin	60-73	endothelin-1	Cavia porcellus	86-90
8587335-5	1995	The large conductance Ca(2+)-activated K(+)-channel blocker charybdotoxin antagonized ET-1- and ET-3-induced relaxations.	Charybdotoxin	60-73	endothelin-3	Cavia porcellus	96-100
7999110-2	1994	Relaxations to CNP in isolated coronary arteries were significantly attenuated with potassium channel antagonists charybdotoxin (10(-7)M) and glibenclamide (10(-7)M).	Charybdotoxin	114-127	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	15-18
7518400-6	1994	The Kv1.3 channel was identified by its physiological (a very low recovery from inactivation) and its pharmacological properties (a high sensitivity to charybdotoxin).	Charybdotoxin	152-165	potassium channel, voltage gated shaker related subfamily A, member 3 S homeolog	Xenopus laevis	4-9
7518702-7	1994	Reconstituted Slo KCa channels were insensitive to external charybdotoxin (40-500 nM) and sensitive to micromolar concentrations of external tetraethylammonium (KD = 158 microM, at 0 mV) and internal Ba2+ (KD = 76 microM, at 40 mV).	Charybdotoxin	60-73	potassium calcium-activated channel subfamily M alpha 1 L homeolog	Xenopus laevis	14-17
8148397-1	1994	The receptor-mediated agonist, neurotensin (NT) stimulated Ba(2+)- and charybdotoxin-sensitive 86Rb (K+) efflux in the HT29-19A colonic cell line.	Charybdotoxin	71-84	neurotensin	Homo sapiens	31-42
7505914-12	1993	These results indicate that ChTX is the most efficient known toxin against the epithelial BKCa in primary cultures of PCT.	Charybdotoxin	28-32	calcium-activated potassium channel subunit alpha-1	Oryctolagus cuniculus	90-94
7525941-4	1994	Both IbTx (100 nM) and ChTx (100 nM) were found to inhibit the L-NNA-sensitive relaxations elicited by field stimulation and to inhibit the relaxations to SIN-1.	Charybdotoxin	23-27	MAPK associated protein 1	Homo sapiens	155-160
7532095-3	1994	Charybdotoxin, another Ca(2+)-activated K+ channel-blocker, also induced PRL secretion at 20 nM concentration.	Charybdotoxin	0-13	prolactin	Rattus norvegicus	73-76
7532095-5	1994	Both 10 microM dopamine and 2 microM nifedipine significantly, but incompletely, depressed PRL secretion induced by 100 nM apamin; 10 microM dopamine completely blocked PRL secretion induced by 20 nM charybdotoxin.	Charybdotoxin	200-213	prolactin	Rattus norvegicus	169-172
7507992-6	1994	Charybdotoxin (100 nM) is known to block large conductance calcium-activated potassium channels, and it attenuated the neuromodulatory effects of ANF; however, the effects of BRL 38227 were sustained in the presence of charybdotoxin.	Charybdotoxin	0-13	natriuretic peptides A	Oryctolagus cuniculus	146-149
1280351-0	1992	Charybdotoxin, dendrotoxin and mast cell degranulating peptide block the voltage-activated K+ current of fibroblast cells stably transfected with NGK1 (Kv1.2) K+ channel complementary DNA.	Charybdotoxin	0-13	potassium voltage-gated channel, shaker-related subfamily, member 2	Mus musculus	152-157
7680230-2	1993	Despite these structural similarities, IbTX and ChTX differ in their selectivity for two types of potassium channels; large conductance calcium-activated potassium (maxi-K) channels and slowly inactivating voltage-gated (Kv1.3) potassium channels.	Charybdotoxin	48-52	potassium channel, voltage gated shaker related subfamily A, member 3 S homeolog	Xenopus laevis	221-226
7680230-3	1993	ChTX blocks with high affinity both maxi-K and Kv1.3 channels, while IbTX blocks the maxi-K but not the voltage-gated channel.	Charybdotoxin	0-4	potassium channel, voltage gated shaker related subfamily A, member 3 S homeolog	Xenopus laevis	47-52
1281425-6	1992	At low cRNA concentrations, the expressed Kv1.2 channel is also blocked by other polypeptide toxins such as MCD peptide (IC50 = 20 nM), charybdotoxin (IC50 = 50 nM), and beta-bungarotoxin (IC50 = 50 nM), which bind to distinct and allosterically related sites on the channel protein.	Charybdotoxin	136-149	potassium channel, voltage gated shaker related subfamily A, member 2 L homeolog	Xenopus laevis	42-47
1281185-3	1992	ChTX inhibited proliferation of PBMC and purified T cells, decreased IL-2 elaboration 15 h after stimulation by 78.4 +/- 5.3% (n = 5), and decreased IL-2 mRNA steady-state levels by 80% between 8 and 10 h after stimulation.	Charybdotoxin	0-4	interleukin 2	Homo sapiens	69-73
1281185-3	1992	ChTX inhibited proliferation of PBMC and purified T cells, decreased IL-2 elaboration 15 h after stimulation by 78.4 +/- 5.3% (n = 5), and decreased IL-2 mRNA steady-state levels by 80% between 8 and 10 h after stimulation.	Charybdotoxin	0-4	interleukin 2	Homo sapiens	149-153
1281185-4	1992	The IC50 for ChTX-inhibition of IL-2 elaboration and IL-2 mRNA were both 1 nM.	Charybdotoxin	13-17	interleukin 2	Homo sapiens	32-36
1281185-4	1992	The IC50 for ChTX-inhibition of IL-2 elaboration and IL-2 mRNA were both 1 nM.	Charybdotoxin	13-17	interleukin 2	Homo sapiens	53-57
7686105-1	1993	In isolated guinea pig trachea contracted by 0.5 mM acetylcholine, the cumulative relaxant concentration-response curves to the beta 2-adrenoceptor agonist, salbutamol, were shifted to the right by depolarizing concentrations of KCl, as well as by charybdotoxin, iberiotoxin and tetraethylammonium ion, which are antagonists of the high-conductance Ca(2+)-activated K+ channel.	Charybdotoxin	248-261	beta-2 adrenergic receptor	Cavia porcellus	128-147
7679705-3	1993	ChTX blocks T cell activation induced by signals (e.g., anti-CD2, anti-CD3, ionomycin) that elicit a rise in intracellular calcium ([Ca2+]i) by preventing the elevation of [Ca2+]i in a dose-dependent manner.	Charybdotoxin	0-4	CD2 molecule	Homo sapiens	61-64
1446675-4	1992	Our results show that alpha-dendrotoxin and peptides of the LQ venom with an apparent molecular mass of about 4.0 kDa, probably isoforms of charybdotoxin, specifically bind to CF0CF1.	Charybdotoxin	140-153	ultraspiracle	Drosophila melanogaster	176-182
1282927-9	1992	In guinea-pigs, ChTX (10 nM) significantly reversed the prejunctional inhibition of cholinergic contraction by NPY (84.2 +/- 16.2%), clonidine (71.9 +/- 22.4%), DAMGO (67.3 +/- 13.1%) and lemakalim (20.9 +/- 9.4%) (n = 5, P < 0.05, respectively), while apamin (100 nM) had no effect.	Charybdotoxin	16-20	pro-neuropeptide Y	Cavia porcellus	111-114
1282927-12	1992	Pretreatment with ChTX (10 nM) significantly reduced the inhibitory modulation of cholinergic nerves by NPY, clonidine and DAMGO, but not by lemakalim.	Charybdotoxin	18-22	neuropeptide Y	Homo sapiens	104-107
2110977-5	1990	BRL 34915 and P 1060 specifically increase the open-state probability of the Ca+(+)-activated K+ (maxi-K+) channel, and these actions are blocked by glyburide and also by charybdotoxin.	Charybdotoxin	171-184	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	98-114
1377376-6	1992	This small-conductance, charybdotoxin-sensitive, Ca(2+)-regulated K+ channel is activated by vasoconstrictors such as vasopressin and endothelin.	Charybdotoxin	24-37	arginine vasopressin	Rattus norvegicus	118-129
1593449-21	1992	The Kdr channel was not blocked by tetraethylammonium (TEA; 1 mM), charybdotoxin (ChTX; 100 nM) or glibenclamide (20 microM), but was blocked by 4-aminopyridine (4-AP; 1 mM).	Charybdotoxin	82-86	kinase insert domain receptor	Canis lupus familiaris	4-7
1993474-3	1991	Compared to other members of the RCK family the pharmacological profile of RCK2 was unique in that the channel was resistant to block (IC50 = 3.3 microM) by charybdotoxin [(1988) Proc.	Charybdotoxin	157-170	potassium voltage-gated channel subfamily A member 6	Rattus norvegicus	75-79
1373731-13	1992	HLK3 current is very sensitive to the scorpion toxin charybdotoxin (IC50 = 0.8 nM).	Charybdotoxin	53-66	potassium voltage-gated channel subfamily A member 3	Homo sapiens	0-4
1371308-4	1992	Unlike the voltage-gated (type n) K+ channels in these cells, the majority of K(Ca) channels are insensitive to block by charybdotoxin (CTX) or 4-aminopyridine (4-AP), but are highly sensitive to block by apamin (Kd less than 1 nM).	Charybdotoxin	121-134	casein kappa	Homo sapiens	78-83
1706715-3	1991	The [Ca2+]i response by EGF was little changed by charybdotoxin while the parallel hyperpolarization was inhibited in a dose-dependent manner.	Charybdotoxin	50-63	epidermal growth factor	Mus musculus	24-27
1706715-8	1991	In contrast, growth stimulated by EGF was inhibited, moderately (-20%) by charybdotoxin and markedly (-60%) by SC38249.	Charybdotoxin	74-87	epidermal growth factor	Mus musculus	34-37
1704892-2	1991	Charybdotoxin (ChTX) inhibits with high affinity a voltage-gated K+ channel that is present in human T lymphocytes.	Charybdotoxin	0-13	potassium voltage-gated channel subfamily D member 3	Homo sapiens	51-75
1704892-2	1991	Charybdotoxin (ChTX) inhibits with high affinity a voltage-gated K+ channel that is present in human T lymphocytes.	Charybdotoxin	15-19	potassium voltage-gated channel subfamily D member 3	Homo sapiens	51-75
1704892-11	1991	These data, taken together, suggest that 125I-ChTX binding sites identified in this study, represent the predominant voltage-gated K+ channel present in peripheral human T lymphocytes.	Charybdotoxin	46-50	potassium voltage-gated channel subfamily D member 3	Homo sapiens	117-141
12106193-11	1991	We now demonstrate, using 86Rb+ influx assays and single channel patch-clamp recording, that both endothelins-ET-3 and ET-1-can also open a charybdotoxin-sensitive, calcium-activated K+ channel of 15 - 40 pS in glial cells.	Charybdotoxin	140-153	endothelin 3	Homo sapiens	110-114
12106193-11	1991	We now demonstrate, using 86Rb+ influx assays and single channel patch-clamp recording, that both endothelins-ET-3 and ET-1-can also open a charybdotoxin-sensitive, calcium-activated K+ channel of 15 - 40 pS in glial cells.	Charybdotoxin	140-153	endothelin 1	Homo sapiens	119-123
19912772-7	1990	Also, although all three channels are sensitive to the K(+) channel blocker, 4-aminopyridine, only HuKI has tetraethylammonium sensitivity; only HuKIV has charybdotoxin sensitivity.	Charybdotoxin	155-168	potassium voltage-gated channel subfamily A member 2	Homo sapiens	145-150
19255162-9	2009	Blocking of SK(Ca) and IK(Ca) channels with apamin plus charybdotoxin or blocking of SK(Ca) channels alone in the absence and the presence of indomethacin markedly reduced bradykinin and NS309 relaxation, whereas blocking of IK(Ca) channels had no significant effect.	Charybdotoxin	56-69	kininogen 1	Homo sapiens	172-182
1693683-8	1990	Potassium currents were also reversibly suppressed by 8 nM-charybdotoxin but unaffected by 100 nM-apamin, suggesting that the Ca2(+)-dependent K+ current was carried through large or intermediate conductance Ca2(+)-activated K+ channels.	Charybdotoxin	59-72	carbonic anhydrase 2	Rattus norvegicus	126-129
2408068-6	1990	(2) Charybdotoxin (ChTX), a rather specific probe for PKCa channels, has been purified to homogeneity, characterized in terms of primary sequence, labeled with 125I, and used to study binding of ChTX to the receptor/channel complex.	Charybdotoxin	4-17	protein kinase C alpha	Bos taurus	54-58
2408068-6	1990	(2) Charybdotoxin (ChTX), a rather specific probe for PKCa channels, has been purified to homogeneity, characterized in terms of primary sequence, labeled with 125I, and used to study binding of ChTX to the receptor/channel complex.	Charybdotoxin	19-23	protein kinase C alpha	Bos taurus	54-58