PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27499734-10	2016	The released ectodomain of Lasso retains its functional properties and binds latrophilin-1 expressed on other cells; this binding stimulates intracellular Ca(2+) signaling in the target cells.	alachlor	27-32	adhesion G protein-coupled receptor L1	Homo sapiens	77-90
27376881-1	2017	In the Saccharomyces cerevisiae eukaryotic model, the induction of the iron regulon genes ARN1, FIT2 and CTH2 by growth-inhibitory concentrations of alachlor (ALA) was dependent on Aft1p expression.	alachlor	149-157	siderophore transporter	Saccharomyces cerevisiae S288C	90-94
27376881-1	2017	In the Saccharomyces cerevisiae eukaryotic model, the induction of the iron regulon genes ARN1, FIT2 and CTH2 by growth-inhibitory concentrations of alachlor (ALA) was dependent on Aft1p expression.	alachlor	149-157	Fit2p	Saccharomyces cerevisiae S288C	96-100
27376881-1	2017	In the Saccharomyces cerevisiae eukaryotic model, the induction of the iron regulon genes ARN1, FIT2 and CTH2 by growth-inhibitory concentrations of alachlor (ALA) was dependent on Aft1p expression.	alachlor	149-157	Tis11p	Saccharomyces cerevisiae S288C	105-109
27376881-1	2017	In the Saccharomyces cerevisiae eukaryotic model, the induction of the iron regulon genes ARN1, FIT2 and CTH2 by growth-inhibitory concentrations of alachlor (ALA) was dependent on Aft1p expression.	alachlor	149-157	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	181-186
27376881-1	2017	In the Saccharomyces cerevisiae eukaryotic model, the induction of the iron regulon genes ARN1, FIT2 and CTH2 by growth-inhibitory concentrations of alachlor (ALA) was dependent on Aft1p expression.	alachlor	159-162	siderophore transporter	Saccharomyces cerevisiae S288C	90-94
27376881-1	2017	In the Saccharomyces cerevisiae eukaryotic model, the induction of the iron regulon genes ARN1, FIT2 and CTH2 by growth-inhibitory concentrations of alachlor (ALA) was dependent on Aft1p expression.	alachlor	159-162	Fit2p	Saccharomyces cerevisiae S288C	96-100
27376881-1	2017	In the Saccharomyces cerevisiae eukaryotic model, the induction of the iron regulon genes ARN1, FIT2 and CTH2 by growth-inhibitory concentrations of alachlor (ALA) was dependent on Aft1p expression.	alachlor	159-162	Tis11p	Saccharomyces cerevisiae S288C	105-109
27376881-1	2017	In the Saccharomyces cerevisiae eukaryotic model, the induction of the iron regulon genes ARN1, FIT2 and CTH2 by growth-inhibitory concentrations of alachlor (ALA) was dependent on Aft1p expression.	alachlor	159-162	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	181-186
27376881-3	2017	The hypersensitivity of the aft1Delta mutant to ALA was abrogated by surplus exogenous iron, suggesting that the role of Aft1p in ALA tolerance may be associated with iron limitation under ALA stress.	alachlor	48-51	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	121-126
27376881-3	2017	The hypersensitivity of the aft1Delta mutant to ALA was abrogated by surplus exogenous iron, suggesting that the role of Aft1p in ALA tolerance may be associated with iron limitation under ALA stress.	alachlor	130-133	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	121-126
27376881-3	2017	The hypersensitivity of the aft1Delta mutant to ALA was abrogated by surplus exogenous iron, suggesting that the role of Aft1p in ALA tolerance may be associated with iron limitation under ALA stress.	alachlor	130-133	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	121-126
27376881-5	2017	In contrast to the upregulation of the nonreductive iron uptake genes ARN1 and FIT2 by ALA, the quantity of FET3 and FTR1 transcripts encoding the high-affinity iron uptake reductive pathway decreased.	alachlor	87-90	siderophore transporter	Saccharomyces cerevisiae S288C	70-74
27376881-5	2017	In contrast to the upregulation of the nonreductive iron uptake genes ARN1 and FIT2 by ALA, the quantity of FET3 and FTR1 transcripts encoding the high-affinity iron uptake reductive pathway decreased.	alachlor	87-90	Fit2p	Saccharomyces cerevisiae S288C	79-83
26646468-3	2015	Experimental results revealed that the alachlor oxidation enhancement in the syn-FeS2 Fenton system was attributed to the molecular oxygen activation induced by more surface-bound ferrous ions on syn-FeS2.	alachlor	39-47	synemin	Homo sapiens	77-80
26646468-3	2015	Experimental results revealed that the alachlor oxidation enhancement in the syn-FeS2 Fenton system was attributed to the molecular oxygen activation induced by more surface-bound ferrous ions on syn-FeS2.	alachlor	39-47	synemin	Homo sapiens	196-199
26518674-4	2015	It is likely that alachlor-induced oxidative stress may result from protein denaturation because alachlor rapidly induced an increased protein aggregation, leading to upregulation of SSA4 and HSP82 genes encoding heat shock proteins (Hsp) of Hsp70 and Hsp90 family, respectively.	alachlor	18-26	Hsp70 family chaperone SSA4	Saccharomyces cerevisiae S288C	183-187
26646468-2	2015	The alachlor degradation rate of syn-FeS2 heterogeneous Fenton system was almost 55 times that of its commercial pyrite (com-FeS2) counterpart at an initial pH of 6.2.	alachlor	4-12	synemin	Homo sapiens	33-36
26518674-4	2015	It is likely that alachlor-induced oxidative stress may result from protein denaturation because alachlor rapidly induced an increased protein aggregation, leading to upregulation of SSA4 and HSP82 genes encoding heat shock proteins (Hsp) of Hsp70 and Hsp90 family, respectively.	alachlor	18-26	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	192-197
26518674-4	2015	It is likely that alachlor-induced oxidative stress may result from protein denaturation because alachlor rapidly induced an increased protein aggregation, leading to upregulation of SSA4 and HSP82 genes encoding heat shock proteins (Hsp) of Hsp70 and Hsp90 family, respectively.	alachlor	18-26	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	252-257
26518674-4	2015	It is likely that alachlor-induced oxidative stress may result from protein denaturation because alachlor rapidly induced an increased protein aggregation, leading to upregulation of SSA4 and HSP82 genes encoding heat shock proteins (Hsp) of Hsp70 and Hsp90 family, respectively.	alachlor	97-105	Hsp70 family chaperone SSA4	Saccharomyces cerevisiae S288C	183-187
26518674-4	2015	It is likely that alachlor-induced oxidative stress may result from protein denaturation because alachlor rapidly induced an increased protein aggregation, leading to upregulation of SSA4 and HSP82 genes encoding heat shock proteins (Hsp) of Hsp70 and Hsp90 family, respectively.	alachlor	97-105	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	192-197
26518674-4	2015	It is likely that alachlor-induced oxidative stress may result from protein denaturation because alachlor rapidly induced an increased protein aggregation, leading to upregulation of SSA4 and HSP82 genes encoding heat shock proteins (Hsp) of Hsp70 and Hsp90 family, respectively.	alachlor	97-105	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	252-257
26518674-5	2015	Although only SOD1 encoding Cu/Zn-superoxide dismutase (SOD), but not SOD2 encoding Mn-SOD, is essential for alachlor tolerance, both SODs play a crucial role in reducing alachlor-induced ROS.	alachlor	109-117	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	14-18
26518674-5	2015	Although only SOD1 encoding Cu/Zn-superoxide dismutase (SOD), but not SOD2 encoding Mn-SOD, is essential for alachlor tolerance, both SODs play a crucial role in reducing alachlor-induced ROS.	alachlor	171-179	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	14-18
24086091-0	2013	ORACLE INEQUALITIES FOR THE LASSO IN THE COX MODEL.	alachlor	28-33	cytochrome c oxidase subunit 8A	Homo sapiens	41-44
24928877-1	2014	Sphingomonads DC-6 and DC-2 degrade the chloroacetanilide herbicides alachlor, acetochlor, and butachlor via N-dealkylation.	alachlor	69-77	ENY2 transcription and export complex 2 subunit	Homo sapiens	14-18
24928877-1	2014	Sphingomonads DC-6 and DC-2 degrade the chloroacetanilide herbicides alachlor, acetochlor, and butachlor via N-dealkylation.	alachlor	69-77	monoacylglycerol O-acyltransferase 1	Homo sapiens	23-27
21802202-4	2011	The photoelectrochemical (PECH) and photoelectrocatalytic (PEC) properties of WT and TNT photoelectrodes were investigated by photocurrent transient, open-circuit potential and degradation rate of alachlor under the artificial solar light illumination.	alachlor	197-205	chromosome 16 open reading frame 82	Homo sapiens	85-88
21802202-6	2011	The photocatalytic (PC) and PEC experiments of alachlor showed that PC and PEC activities of TNT photoelectrodes were superior to WT photoelectrodes.	alachlor	47-55	chromosome 16 open reading frame 82	Homo sapiens	93-96
19425180-4	2009	Because we have previously shown that matrix metalloproteinase-2 (MMP2) is activated in OM by alachlor, in the present studies we evaluated both MMP2 activation and changes in OM gene expression in response to carcinogenic and non-carcinogenic chloracetanilide treatments.	alachlor	94-102	matrix metallopeptidase 2	Rattus norvegicus	38-64
20832166-4	2010	In addition, the TOC removal efficiencies of the alachlor under initial H(2)O(2) concentrations of 0, 0.5 and 1.0 muM were 59.5, 74.8 and 83.8%, respectively, at an absorbed dose of 20 k Gy.	alachlor	49-57	latexin	Homo sapiens	114-117
20832166-5	2010	However, for higher H(2)O(2) concentrations (greater than 1 muM), the alachlor degradation was reduced because OH radicals were scavenged by the H(2)O(2).	alachlor	70-78	latexin	Homo sapiens	60-63
19425180-4	2009	Because we have previously shown that matrix metalloproteinase-2 (MMP2) is activated in OM by alachlor, in the present studies we evaluated both MMP2 activation and changes in OM gene expression in response to carcinogenic and non-carcinogenic chloracetanilide treatments.	alachlor	94-102	matrix metallopeptidase 2	Rattus norvegicus	66-70
16315095-5	2005	CYP2C49 rice plants showed tolerance towards 13 herbicides, including chlortoluron (100 microM), norflurazon (0.5 microM), amiprofos-methyl (2.5 microM), alachlor (0.8 microM), and isoxaben (1 microM).	alachlor	154-162	cytochrome P450 2C49	Sus scrofa	0-7
18433974-4	2008	We tested the interaction of the herbicides acetochlor, alachlor, dimetachlor, metazachlor, metolachlor, propachlor and prynachlor with human multidrug resistance transporters MDR1, MRP1, MRP2 and BCRP.	alachlor	56-64	ATP binding cassette subfamily B member 1	Homo sapiens	176-180
18433974-4	2008	We tested the interaction of the herbicides acetochlor, alachlor, dimetachlor, metazachlor, metolachlor, propachlor and prynachlor with human multidrug resistance transporters MDR1, MRP1, MRP2 and BCRP.	alachlor	56-64	ATP binding cassette subfamily C member 1	Homo sapiens	182-186
18433974-8	2008	Acetochlor, alachlor, metolachlor and metazachlor showed specific interactions with MDR1.	alachlor	12-20	ATP binding cassette subfamily B member 1	Homo sapiens	84-88
17207564-1	2007	Alachlor is cytotoxic to human hepatoblastoma HepG2s, a cell line that expresses constitutive CYP3A7 and dexamethasone (DEX)-inducible CYP3A4 and CYP3A7.	alachlor	0-8	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	94-100
17207564-1	2007	Alachlor is cytotoxic to human hepatoblastoma HepG2s, a cell line that expresses constitutive CYP3A7 and dexamethasone (DEX)-inducible CYP3A4 and CYP3A7.	alachlor	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	135-141
17207564-1	2007	Alachlor is cytotoxic to human hepatoblastoma HepG2s, a cell line that expresses constitutive CYP3A7 and dexamethasone (DEX)-inducible CYP3A4 and CYP3A7.	alachlor	0-8	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	146-152
17207564-3	2007	We hypothesized that HepG2 alachlor cytotoxicity would be mediated by CYP3A4/7 and increased with DEX.	alachlor	27-35	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	70-76
16538523-9	2006	Our results reveal that AtGSTU26 is induced by the chloroacetanilide herbicides alachlor and metolachlor and the safener benoxacor, and after exposure to low temperatures.	alachlor	80-88	glutathione S-transferase tau 26	Arabidopsis thaliana	24-32
16277416-3	2005	In particular, CYP2B6 rice plants grown in soil showed tolerance to the chloroacetanilide herbicides alachlor and metolachlor.	alachlor	101-109	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	15-21
15907790-9	2005	These results indicate that alachlor and carbaryl differentially impair the LPS-induced NF-kappaB activation, leading to the inhibition of NO production.	alachlor	28-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	88-97
16268142-1	2005	Second-order rate constants (kNuc) for aqueous-phase bimolecular nucleophilic substitution (SN2) reactions of a range of anionic nucleophiles with alachlor, propachlor, and two analogs of propachlor (a thioacetanilide and a beta-anilide) were fit to the Swain-Scott and Edwards models.	alachlor	147-155	solute carrier family 38 member 5	Homo sapiens	92-95
15907790-0	2005	Alachlor and carbaryl suppress lipopolysaccharide-induced iNOS expression by differentially inhibiting NF-kappaB activation.	alachlor	0-8	nitric oxide synthase 2, inducible	Mus musculus	58-62
15256756-5	2004	Zineb and alachlor, on the other hand, enhanced LPS-induced TNF-alpha production by mouse peritoneal macrophages ex vivo, while alachlor inhibited LPS/interferon-gamma-induced NO production ex vivo.	alachlor	10-18	toll-like receptor 4	Mus musculus	48-51
15907790-0	2005	Alachlor and carbaryl suppress lipopolysaccharide-induced iNOS expression by differentially inhibiting NF-kappaB activation.	alachlor	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	103-112
15907790-8	2005	LPS-induced nuclear translocation of NF-kappaB, which is necessary for the expression of IFN-beta and iNOS, was inhibited by these chemicals: however, the LPS-induced degradation of IkappaB-alpha and IkappaB-beta was inhibited only by alachlor.	alachlor	235-243	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	37-46
15907790-8	2005	LPS-induced nuclear translocation of NF-kappaB, which is necessary for the expression of IFN-beta and iNOS, was inhibited by these chemicals: however, the LPS-induced degradation of IkappaB-alpha and IkappaB-beta was inhibited only by alachlor.	alachlor	235-243	interferon beta 1, fibroblast	Mus musculus	89-97
15907790-8	2005	LPS-induced nuclear translocation of NF-kappaB, which is necessary for the expression of IFN-beta and iNOS, was inhibited by these chemicals: however, the LPS-induced degradation of IkappaB-alpha and IkappaB-beta was inhibited only by alachlor.	alachlor	235-243	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	182-195
15907790-8	2005	LPS-induced nuclear translocation of NF-kappaB, which is necessary for the expression of IFN-beta and iNOS, was inhibited by these chemicals: however, the LPS-induced degradation of IkappaB-alpha and IkappaB-beta was inhibited only by alachlor.	alachlor	235-243	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta	Mus musculus	200-212
15580706-2	2004	Progression of alachlor-induced olfactory tumors in rats is accompanied by cytoplasmic accumulation and nuclear localization of beta-catenin, suggesting activation of Wint signaling.	alachlor	15-23	catenin beta 1	Rattus norvegicus	128-140
15580706-7	2004	No olfactory mucosal tumors were observed in any of the mice, although alachlor-treated Apc(Min/+) mice developed histological changes similar to those in alachlor-treated rats.	alachlor	71-79	APC, WNT signaling pathway regulator	Mus musculus	88-91
15580706-11	2004	and mice had induced hepatic CYP3A and CYP2B enzymes with alachlor treatment, which may increase alachlor elimination.	alachlor	58-66	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	29-34
15580706-11	2004	and mice had induced hepatic CYP3A and CYP2B enzymes with alachlor treatment, which may increase alachlor elimination.	alachlor	58-66	cytochrome P450, family 2, subfamily b, polypeptide 9	Mus musculus	39-44
15580706-11	2004	and mice had induced hepatic CYP3A and CYP2B enzymes with alachlor treatment, which may increase alachlor elimination.	alachlor	97-105	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	29-34
15580706-11	2004	and mice had induced hepatic CYP3A and CYP2B enzymes with alachlor treatment, which may increase alachlor elimination.	alachlor	97-105	cytochrome P450, family 2, subfamily b, polypeptide 9	Mus musculus	39-44
15256756-4	2004	Carbaryl, alachlor, nonylphenol, octylphenol, tributyltin, and triphenyltin inhibited LPS-induced NO production in vitro, whereas 2,4-dichlorophenoxy acetic acid and bisphenol A enhanced its production.	alachlor	10-18	toll-like receptor 4	Mus musculus	86-89
16178123-2	2005	Genomic analysis of olfactory mucosa from rats given alachlor (126 mg/kg/d) for from 1 day to 18 mo suggested that matrix metalloproteinases MMP-2 and MMP-9 were upregulated in the month following initiation of treatment.	alachlor	53-61	matrix metallopeptidase 2	Rattus norvegicus	141-146
16178123-2	2005	Genomic analysis of olfactory mucosa from rats given alachlor (126 mg/kg/d) for from 1 day to 18 mo suggested that matrix metalloproteinases MMP-2 and MMP-9 were upregulated in the month following initiation of treatment.	alachlor	53-61	matrix metallopeptidase 9	Rattus norvegicus	151-156
16178123-4	2005	Zymographic analysis of olfactory mucosal extracts confirmed that MMP-2 activity is higher in the olfactory mucosa of alachlor-treated rats.	alachlor	118-126	matrix metallopeptidase 2	Rattus norvegicus	66-71
16178123-8	2005	These data confirm that olfactory mucosal MMP-2 activity is increased following short-term alachlor exposure and show that administration of an MMP-2/9 inhibitor reduced the incidence of olfactory neoplasms in alachlor-treated rats, thereby implicating MMP-2 activity as a mediator of alachlor-induced carcinogenicity.	alachlor	91-99	matrix metallopeptidase 2	Rattus norvegicus	42-47
16178123-8	2005	These data confirm that olfactory mucosal MMP-2 activity is increased following short-term alachlor exposure and show that administration of an MMP-2/9 inhibitor reduced the incidence of olfactory neoplasms in alachlor-treated rats, thereby implicating MMP-2 activity as a mediator of alachlor-induced carcinogenicity.	alachlor	91-99	matrix metallopeptidase 2	Rattus norvegicus	144-151
16178123-8	2005	These data confirm that olfactory mucosal MMP-2 activity is increased following short-term alachlor exposure and show that administration of an MMP-2/9 inhibitor reduced the incidence of olfactory neoplasms in alachlor-treated rats, thereby implicating MMP-2 activity as a mediator of alachlor-induced carcinogenicity.	alachlor	91-99	matrix metallopeptidase 2	Rattus norvegicus	144-149
16178123-8	2005	These data confirm that olfactory mucosal MMP-2 activity is increased following short-term alachlor exposure and show that administration of an MMP-2/9 inhibitor reduced the incidence of olfactory neoplasms in alachlor-treated rats, thereby implicating MMP-2 activity as a mediator of alachlor-induced carcinogenicity.	alachlor	210-218	matrix metallopeptidase 2	Rattus norvegicus	42-47
16178123-8	2005	These data confirm that olfactory mucosal MMP-2 activity is increased following short-term alachlor exposure and show that administration of an MMP-2/9 inhibitor reduced the incidence of olfactory neoplasms in alachlor-treated rats, thereby implicating MMP-2 activity as a mediator of alachlor-induced carcinogenicity.	alachlor	210-218	matrix metallopeptidase 2	Rattus norvegicus	144-151
16178123-8	2005	These data confirm that olfactory mucosal MMP-2 activity is increased following short-term alachlor exposure and show that administration of an MMP-2/9 inhibitor reduced the incidence of olfactory neoplasms in alachlor-treated rats, thereby implicating MMP-2 activity as a mediator of alachlor-induced carcinogenicity.	alachlor	210-218	matrix metallopeptidase 2	Rattus norvegicus	144-149
16178123-8	2005	These data confirm that olfactory mucosal MMP-2 activity is increased following short-term alachlor exposure and show that administration of an MMP-2/9 inhibitor reduced the incidence of olfactory neoplasms in alachlor-treated rats, thereby implicating MMP-2 activity as a mediator of alachlor-induced carcinogenicity.	alachlor	210-218	matrix metallopeptidase 2	Rattus norvegicus	42-47
16178123-8	2005	These data confirm that olfactory mucosal MMP-2 activity is increased following short-term alachlor exposure and show that administration of an MMP-2/9 inhibitor reduced the incidence of olfactory neoplasms in alachlor-treated rats, thereby implicating MMP-2 activity as a mediator of alachlor-induced carcinogenicity.	alachlor	210-218	matrix metallopeptidase 2	Rattus norvegicus	144-151
16178123-8	2005	These data confirm that olfactory mucosal MMP-2 activity is increased following short-term alachlor exposure and show that administration of an MMP-2/9 inhibitor reduced the incidence of olfactory neoplasms in alachlor-treated rats, thereby implicating MMP-2 activity as a mediator of alachlor-induced carcinogenicity.	alachlor	210-218	matrix metallopeptidase 2	Rattus norvegicus	144-149
15256756-5	2004	Zineb and alachlor, on the other hand, enhanced LPS-induced TNF-alpha production by mouse peritoneal macrophages ex vivo, while alachlor inhibited LPS/interferon-gamma-induced NO production ex vivo.	alachlor	10-18	tumor necrosis factor	Mus musculus	60-69
15256756-5	2004	Zineb and alachlor, on the other hand, enhanced LPS-induced TNF-alpha production by mouse peritoneal macrophages ex vivo, while alachlor inhibited LPS/interferon-gamma-induced NO production ex vivo.	alachlor	128-136	toll-like receptor 4	Mus musculus	147-150
15256756-5	2004	Zineb and alachlor, on the other hand, enhanced LPS-induced TNF-alpha production by mouse peritoneal macrophages ex vivo, while alachlor inhibited LPS/interferon-gamma-induced NO production ex vivo.	alachlor	128-136	interferon gamma	Mus musculus	151-167
10475613-6	1999	Further, we have screened human cytochrome P450 isoforms 1A1, 1A2, 2B6, 2C8, 2C9, 2C18, 2C19, 2D6, 2E1, and 3A4 and determined that human CYP 3A4 is responsible for metabolism of alachlor to CDEPA.	alachlor	179-187	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	138-145
14753779-1	2004	The metabolism of the acetanilide herbicide alachlor in soils leads to the formation of alachlor-ethanesulfonic acid (alachlor-ESA) as one of the major transformation products of this compound.	alachlor	44-52	paraoxonase 1	Homo sapiens	127-130
12419858-3	2002	Acute alachlor exposure caused upregulation of matrix metalloproteinases (MMP)-2 and -9, tissue inhibitor of metalloproteinase-1, carboxypeptidase Z, and other genes related to extracellular matrix homeostasis.	alachlor	6-14	matrix metallopeptidase 2	Rattus norvegicus	47-87
12419858-3	2002	Acute alachlor exposure caused upregulation of matrix metalloproteinases (MMP)-2 and -9, tissue inhibitor of metalloproteinase-1, carboxypeptidase Z, and other genes related to extracellular matrix homeostasis.	alachlor	6-14	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	89-128
12419858-3	2002	Acute alachlor exposure caused upregulation of matrix metalloproteinases (MMP)-2 and -9, tissue inhibitor of metalloproteinase-1, carboxypeptidase Z, and other genes related to extracellular matrix homeostasis.	alachlor	6-14	carboxypeptidase Z	Rattus norvegicus	130-148
12419858-5	2002	Expression of ebnerin, related to the putative human tumor suppressor gene DMBT1, progressively increased in alachlor-treated olfactory mucosa.	alachlor	109-117	deleted in malignant brain tumors 1	Rattus norvegicus	14-21
12419858-5	2002	Expression of ebnerin, related to the putative human tumor suppressor gene DMBT1, progressively increased in alachlor-treated olfactory mucosa.	alachlor	109-117	deleted in malignant brain tumors 1	Homo sapiens	75-80
12419858-8	2002	These observations suggest that initiation and progression of alachlor-induced olfactory mucosal tumors is associated with alterations in extracellular matrix components, induction of oxidative stress, upregulation of ebnerin, and final transformation to a malignant state by wnt pathway activation.	alachlor	62-70	deleted in malignant brain tumors 1	Rattus norvegicus	218-225
11850968-5	2002	Among the cytochrome P450-dependent monooxygenase activities, 7-pentoxyresorufin O-depentylase, which is associated with CYP2B1, was dose-dependently increased by alachlor.	alachlor	163-171	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	121-127
10075819-7	1999	Incubations of alachlor (0-1000 microM) with human albumin and bovine serum albumin (BSA) resulted in linear adduct formation with both proteins.	alachlor	15-23	albumin	Homo sapiens	70-83
8812207-6	1996	Liver and thyroid weights, hepatic UDPGT activity, and circulating levels of TSH were significantly increased in animals administered alachlor.	alachlor	134-142	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	35-40
9501141-8	1998	Extracts of Escherichia coli cells expressing SBP1 have strong [3H]Saf binding, which, like binding to the native maize protein, is competitively inhibited by the safener dichlormid and the herbicides S-ethyl dipropylthiocarbamate, alachlor, and metolachlor.	alachlor	232-240	SBP-domain protein 1	Zea mays	46-50
12226466-3	1996	In this study we focused on three isoforms, GST I, II, and IV, derived from homo-or heterodimerization of two subunits GST-29 and GST-27, which have been shown to be responsible for reactivity to alachlor.	alachlor	196-204	glutathione S-transferase 1	Zea mays	44-61
12226466-3	1996	In this study we focused on three isoforms, GST I, II, and IV, derived from homo-or heterodimerization of two subunits GST-29 and GST-27, which have been shown to be responsible for reactivity to alachlor.	alachlor	196-204	glutathione S-transferase 1	Zea mays	119-125
12226466-3	1996	In this study we focused on three isoforms, GST I, II, and IV, derived from homo-or heterodimerization of two subunits GST-29 and GST-27, which have been shown to be responsible for reactivity to alachlor.	alachlor	196-204	glutathione S-transferase 4	Zea mays	130-136
8812207-10	1996	The changes in TSH and T3 levels, hepatic UDPGT activity, and liver weights were all reversible on elimination of alachlor from the diet.	alachlor	114-122	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	42-47
1854719-1	1991	Cross-polarization magic-angle spinning (CPMAS) 13C NMR spectroscopy has been used to characterize covalent conjugates of alachlor, an alpha-chloroacetamide hapten, with glutathione (GSH) and bovine serum albumin (BSA).	alachlor	122-130	albumin	Homo sapiens	199-212
7599527-2	1995	The isoforms GST I and GST II are respectively a homodimer of 29-kDa (GST-29) subunits and a heterodimer of 29- and 27-kDa (GST-27) subunits, while GST I is twice as active with 1-chloro-2,4-dinitrobenzene as GST II, GST II is about seven times more active against the herbicide, alachlor.	alachlor	280-288	glutathione S-transferase 1	Zea mays	13-29
7599527-2	1995	The isoforms GST I and GST II are respectively a homodimer of 29-kDa (GST-29) subunits and a heterodimer of 29- and 27-kDa (GST-27) subunits, while GST I is twice as active with 1-chloro-2,4-dinitrobenzene as GST II, GST II is about seven times more active against the herbicide, alachlor.	alachlor	280-288	glutathione S-transferase 1	Zea mays	13-18
8201174-0	1994	Evaluation of commercial immunoassays for the detection of alachlor in milk, eggs and liver.	alachlor	59-67	Weaning weight-maternal milk	Bos taurus	71-75
8201174-5	1994	Alachlor was detected in milk and eggs, but not in livers from hens dosed up to 12 mg/kg body weight.	alachlor	0-8	Weaning weight-maternal milk	Bos taurus	25-29
1755024-2	1991	Chlorfiurecol, trifluralin, alachlor, propham, MCPP and 2,4-DP caused increases in phase I (cytochrome P-450, ethoxycoumarin O-deethylase, and/or aminopyrine N-demethylase) and phase II (microsomal epoxide hydrolase and cytosolic glutathione S-transferase) activities.	alachlor	28-36	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	92-137
1755024-2	1991	Chlorfiurecol, trifluralin, alachlor, propham, MCPP and 2,4-DP caused increases in phase I (cytochrome P-450, ethoxycoumarin O-deethylase, and/or aminopyrine N-demethylase) and phase II (microsomal epoxide hydrolase and cytosolic glutathione S-transferase) activities.	alachlor	28-36	hematopoietic prostaglandin D synthase	Mus musculus	230-255
34260294-0	2021	HMGCS2 in metabolic pathways was associated with overall survival in hepatocellular carcinoma: A LASSO-derived study.	alachlor	97-102	3-hydroxy-3-methylglutaryl-CoA synthase 2	Homo sapiens	0-6
34589629-4	2021	Alachlor with LD50 0.08 mug mL-1 showed the strongest toxic response as compared with other tested herbicides.	alachlor	0-8	L1 cell adhesion molecule	Mus musculus	28-32
35089296-3	2022	The toxic herbicide alachlor was first employed in this study as an objective probe to determine the dechlorination performance, which was quantified by the alachlor removal (Rala), the current efficiency (CEala), and the dechlorination selectivity (Sdes).	alachlor	20-28	RAS like proto-oncogene A	Homo sapiens	175-179
16665913-8	1988	Kinetic analysis of purified GST III indicates that the enzyme has a higher affinity for alachlor (K(m)app = 1.69 millimolar) than for metolachlor (K(m)app = 8.9 millimolar).	alachlor	89-97	glutathione S-transferase 3	Zea mays	29-36
3532034-3	1986	GST III has been shown to act on the herbicide alachlor as well as the commonly used substrate 1-chloro-2,4-dinitrobenzene (CDNB).	alachlor	47-55	glutathione S-transferase 3	Zea mays	0-7
3532034-7	1986	Moreover, expression of one of these clones in E. coli resulted in a GST activity as measured with both CDNB and alachlor, proving that at least one of the clones encodes an active GST III species.	alachlor	113-121	glutathione S-transferase 3	Zea mays	181-188
31921619-8	2019	Accordingly, the LASSO regression algorithm was employed to screen the 14 most representative immune-related genes (PSMD11, PPIA, MIF, BMP5, DKK1, PDGFB, ANGPTL4, IL1R2, THRB, LTBR, TNFRSF1, TNFRSF17, IL20RB, and MC1R) with respect to patient prognosis.	alachlor	17-22	proteasome 26S subunit, non-ATPase 11	Homo sapiens	116-122
33650967-4	2021	We applied the LASSO Logistic Regression analysis, considering only rare variants on young male subsets with extreme phenotype, picking up TLR7 as the most important susceptibility gene.	alachlor	15-20	toll like receptor 7	Homo sapiens	139-143
32877208-9	2020	LASSO regression showed that the CBFuniformity of the enhancing tumour and ETCM were predictive features for p53 mutation.	alachlor	0-5	tumor protein p53	Homo sapiens	109-112
31664889-10	2020	LASSO regression selected 19 immune proteins with non-null coefficients (CCL11, CCL23, CD244, CST5, CXCL1, CXCL5, CXCL10, CX3CL1, FGF-23, IL-5, IL-7, IL-10, IL-17C, MCP-2, MMP-1, SLAMF1, ST1A1, TNF-beta, and TWEAK).	alachlor	0-5	C-C motif chemokine ligand 11	Homo sapiens	73-78
31664889-10	2020	LASSO regression selected 19 immune proteins with non-null coefficients (CCL11, CCL23, CD244, CST5, CXCL1, CXCL5, CXCL10, CX3CL1, FGF-23, IL-5, IL-7, IL-10, IL-17C, MCP-2, MMP-1, SLAMF1, ST1A1, TNF-beta, and TWEAK).	alachlor	0-5	C-C motif chemokine ligand 23	Homo sapiens	80-85
31664889-10	2020	LASSO regression selected 19 immune proteins with non-null coefficients (CCL11, CCL23, CD244, CST5, CXCL1, CXCL5, CXCL10, CX3CL1, FGF-23, IL-5, IL-7, IL-10, IL-17C, MCP-2, MMP-1, SLAMF1, ST1A1, TNF-beta, and TWEAK).	alachlor	0-5	CD244 molecule	Homo sapiens	87-92
31664889-10	2020	LASSO regression selected 19 immune proteins with non-null coefficients (CCL11, CCL23, CD244, CST5, CXCL1, CXCL5, CXCL10, CX3CL1, FGF-23, IL-5, IL-7, IL-10, IL-17C, MCP-2, MMP-1, SLAMF1, ST1A1, TNF-beta, and TWEAK).	alachlor	0-5	cystatin D	Homo sapiens	94-98
31664889-10	2020	LASSO regression selected 19 immune proteins with non-null coefficients (CCL11, CCL23, CD244, CST5, CXCL1, CXCL5, CXCL10, CX3CL1, FGF-23, IL-5, IL-7, IL-10, IL-17C, MCP-2, MMP-1, SLAMF1, ST1A1, TNF-beta, and TWEAK).	alachlor	0-5	C-X-C motif chemokine ligand 1	Homo sapiens	100-105
31664889-10	2020	LASSO regression selected 19 immune proteins with non-null coefficients (CCL11, CCL23, CD244, CST5, CXCL1, CXCL5, CXCL10, CX3CL1, FGF-23, IL-5, IL-7, IL-10, IL-17C, MCP-2, MMP-1, SLAMF1, ST1A1, TNF-beta, and TWEAK).	alachlor	0-5	C-X-C motif chemokine ligand 5	Homo sapiens	107-112
31664889-10	2020	LASSO regression selected 19 immune proteins with non-null coefficients (CCL11, CCL23, CD244, CST5, CXCL1, CXCL5, CXCL10, CX3CL1, FGF-23, IL-5, IL-7, IL-10, IL-17C, MCP-2, MMP-1, SLAMF1, ST1A1, TNF-beta, and TWEAK).	alachlor	0-5	C-X-C motif chemokine ligand 10	Homo sapiens	114-120
31664889-10	2020	LASSO regression selected 19 immune proteins with non-null coefficients (CCL11, CCL23, CD244, CST5, CXCL1, CXCL5, CXCL10, CX3CL1, FGF-23, IL-5, IL-7, IL-10, IL-17C, MCP-2, MMP-1, SLAMF1, ST1A1, TNF-beta, and TWEAK).	alachlor	0-5	C-X3-C motif chemokine ligand 1	Homo sapiens	122-128
31664889-10	2020	LASSO regression selected 19 immune proteins with non-null coefficients (CCL11, CCL23, CD244, CST5, CXCL1, CXCL5, CXCL10, CX3CL1, FGF-23, IL-5, IL-7, IL-10, IL-17C, MCP-2, MMP-1, SLAMF1, ST1A1, TNF-beta, and TWEAK).	alachlor	0-5	fibroblast growth factor 23	Homo sapiens	130-136
31921619-8	2019	Accordingly, the LASSO regression algorithm was employed to screen the 14 most representative immune-related genes (PSMD11, PPIA, MIF, BMP5, DKK1, PDGFB, ANGPTL4, IL1R2, THRB, LTBR, TNFRSF1, TNFRSF17, IL20RB, and MC1R) with respect to patient prognosis.	alachlor	17-22	peptidylprolyl isomerase A	Homo sapiens	124-128
31921619-8	2019	Accordingly, the LASSO regression algorithm was employed to screen the 14 most representative immune-related genes (PSMD11, PPIA, MIF, BMP5, DKK1, PDGFB, ANGPTL4, IL1R2, THRB, LTBR, TNFRSF1, TNFRSF17, IL20RB, and MC1R) with respect to patient prognosis.	alachlor	17-22	platelet derived growth factor subunit B	Homo sapiens	147-152
31657627-0	2019	Cox-LASSO Analysis Reveals a Ten-lncRNA Signature to Predict Outcomes in Patients with High-Grade Serous Ovarian Cancer.	alachlor	4-9	cytochrome c oxidase subunit 8A	Homo sapiens	0-3
31657627-5	2019	We built a 10-lncRNA signature using Cox-LASSO regression to predict the prognosis of patients with HGSOC.	alachlor	41-46	cytochrome c oxidase subunit 8A	Homo sapiens	37-40
31824866-4	2019	To develop an IPS, LASSO Cox analysis was conducted for immune-related genes that were differentially expressed between IDH1wt and IDH1mut LGG patients.	alachlor	19-24	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	120-124
31832113-7	2019	LASSO Cox regression was performed to build a membrane lipid metabolism-based signature.	alachlor	0-5	cytochrome c oxidase subunit 8A	Homo sapiens	6-9
31572440-10	2019	LASSO Cox regression suggested that ZWINT, PRC1, CDKN3, CDK1 and CCNA2 were independent prognostic factors in ACC.	alachlor	0-5	ZW10 interacting kinetochore protein	Homo sapiens	36-41
31385424-6	2019	In addition, by combining the Lasso-penalized Cox regression machine-learning approach with univariate and multivariate Cox regression analyses, we identified a stemness-related gene expression signature that accurately predicted survival in patients with Sonic hedgehog (SHH) MB.	alachlor	30-35	sonic hedgehog signaling molecule	Homo sapiens	256-270
31385424-6	2019	In addition, by combining the Lasso-penalized Cox regression machine-learning approach with univariate and multivariate Cox regression analyses, we identified a stemness-related gene expression signature that accurately predicted survival in patients with Sonic hedgehog (SHH) MB.	alachlor	30-35	sonic hedgehog signaling molecule	Homo sapiens	272-275
30707269-9	2019	Experiments reducing and alkylating the disulfide bond of BI-32169 showed that the lasso structure is preserved and heat stable and the associated conformational changes provide new insights about the role of the disulfide bond in the inhibitory activity against the human glucagon receptor.	alachlor	83-88	glucagon receptor	Homo sapiens	273-290
31933987-7	2019	Using machine learning, LASSO selected the subset of variables that minimized the predictive error of the outcome, including CEA, NSE, CYFRA 21-1, CAMKII, tumor size, histologic type, lymph node status, smoking, and age.	alachlor	24-29	CEA cell adhesion molecule 3	Homo sapiens	125-128
31933987-7	2019	Using machine learning, LASSO selected the subset of variables that minimized the predictive error of the outcome, including CEA, NSE, CYFRA 21-1, CAMKII, tumor size, histologic type, lymph node status, smoking, and age.	alachlor	24-29	enolase 2	Homo sapiens	130-133
31933987-7	2019	Using machine learning, LASSO selected the subset of variables that minimized the predictive error of the outcome, including CEA, NSE, CYFRA 21-1, CAMKII, tumor size, histologic type, lymph node status, smoking, and age.	alachlor	24-29	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	147-153
28467036-3	2017	The apparent alachlor degradation rate constant in the HTC-G/Fe(III)/H2O2 system (7.02 x 10-2 min-1) was about 3 times higher than that in the Fe(III)/H2O2 system (2.25 x 10-2 min-1).	alachlor	13-21	CD59 molecule (CD59 blood group)	Homo sapiens	94-99
28467036-3	2017	The apparent alachlor degradation rate constant in the HTC-G/Fe(III)/H2O2 system (7.02 x 10-2 min-1) was about 3 times higher than that in the Fe(III)/H2O2 system (2.25 x 10-2 min-1).	alachlor	13-21	CD59 molecule (CD59 blood group)	Homo sapiens	176-181