PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32240172-4	2020	RAN translation of the CAG sense and CUG anti-sense RNAs produces six distinct repeat peptides: polyalanine (polyAla, from both CAG and CUG repeats), polyserine (polySer), polyleucine (polyLeu), polycysteine (polyCys), and polyglutamine (polyGln).	polyleucine	185-192	RAN, member RAS oncogene family	Homo sapiens	0-3
3293085-1	1988	Polyglycine, polyalanine, polyleucine, poly-alpha-glutamic acid, poly-gamma-glutamic acid and poly-alpha-lysine were complexed with insulin under non denaturating conditions.	polyleucine	26-37	insulin	Homo sapiens	132-139
32240172-4	2020	RAN translation of the CAG sense and CUG anti-sense RNAs produces six distinct repeat peptides: polyalanine (polyAla, from both CAG and CUG repeats), polyserine (polySer), polyleucine (polyLeu), polycysteine (polyCys), and polyglutamine (polyGln).	polyleucine	172-183	RAN, member RAS oncogene family	Homo sapiens	0-3
35102230-1	2022	Repeat-associated non-AUG (RAN) translation of mRNAs/transcripts responsible for polyglutamine (polyQ) diseases may generate peptides containing different mono amino acid tracts such as polyserine (polyS) and polyleucine (polyL).	polyleucine	209-220	RAN, member RAS oncogene family	Mus musculus	27-30
35102230-1	2022	Repeat-associated non-AUG (RAN) translation of mRNAs/transcripts responsible for polyglutamine (polyQ) diseases may generate peptides containing different mono amino acid tracts such as polyserine (polyS) and polyleucine (polyL).	polyleucine	222-227	RAN, member RAS oncogene family	Mus musculus	27-30
35102230-9	2022	Thus, the RAN translation-related proteins containing polyS and polyL have the potential to propagate and the proteins generated by all polyQ diseases might exert universal toxicity in the recipient cells.	polyleucine	64-69	RAN, member RAS oncogene family	Mus musculus	10-13
32067606-6	2020	L-leucine and its derivatives appear to regulate protein synthesis by direct or indirect activation of the mTORC1 pool of kinases, further promoting muscle protein balance.	polyleucine	0-9	CREB regulated transcription coactivator 1	Mus musculus	107-113
20690642-8	2010	Circular dichroism spectroscopy showed a beta-sheet conformation for aggregates of poly(l-leucine).	polyleucine	83-98	amyloid beta precursor protein	Homo sapiens	39-45
22021427-3	2012	There is emerging evidence that expansions of amino acids encoded by other reading frames of CAG/CUG repeats, including polyalanine and polyleucine, could contribute to toxicity in the "polyglutamine" diseases.	polyleucine	136-147	cag	Drosophila melanogaster	93-96
23566281-4	2013	FINDINGS: Using a case-control strategy, we genotyped 239 migraine patients and 264 controls for three different non-synonymous polymorphisms (T320A, G835V, R1346P) of the NOTCH4 gene and for the (CTG) n-encoding polyleucine polymorphism in exon 1.	polyleucine	213-224	notch receptor 4	Homo sapiens	172-178
22367996-3	2012	In the CTG orientation, the repeat is located within the alternatively spliced exon 2A of junctophilin-3 (JPH3), potentially encoding polyleucine and polyalanine, whereas on the strand antisense to JPH3, the repeat is in frame to encode polyglutamine.	polyleucine	134-145	junctophilin 3	Mus musculus	90-104
22367996-3	2012	In the CTG orientation, the repeat is located within the alternatively spliced exon 2A of junctophilin-3 (JPH3), potentially encoding polyleucine and polyalanine, whereas on the strand antisense to JPH3, the repeat is in frame to encode polyglutamine.	polyleucine	134-145	junctophilin 3	Mus musculus	106-110
21423665-6	2011	Expanded CTG tracts expressing CUG transcripts also show RAN-translation occurring in all three frames (CUG, UGC, and GCU), to produce polyleucine, polycysteine, and polyalanine.	polyleucine	135-146	RAN, member RAS oncogene family	Homo sapiens	57-60
16623599-3	2006	The KIR and NKG2D receptors assembled with the DAP12 and DAP10 dimers, respectively, even when the entire KIR or NKG2D transmembrane domains were replaced by polyleucine sequences with a properly positioned basic residue.	polyleucine	158-169	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	4-7
16623599-3	2006	The KIR and NKG2D receptors assembled with the DAP12 and DAP10 dimers, respectively, even when the entire KIR or NKG2D transmembrane domains were replaced by polyleucine sequences with a properly positioned basic residue.	polyleucine	158-169	killer cell lectin like receptor K1	Homo sapiens	12-17
16623599-3	2006	The KIR and NKG2D receptors assembled with the DAP12 and DAP10 dimers, respectively, even when the entire KIR or NKG2D transmembrane domains were replaced by polyleucine sequences with a properly positioned basic residue.	polyleucine	158-169	transmembrane immune signaling adaptor TYROBP	Homo sapiens	47-52
16623599-3	2006	The KIR and NKG2D receptors assembled with the DAP12 and DAP10 dimers, respectively, even when the entire KIR or NKG2D transmembrane domains were replaced by polyleucine sequences with a properly positioned basic residue.	polyleucine	158-169	hematopoietic cell signal transducer	Homo sapiens	57-62
16285826-2	2005	An amphiphilic copolymer, poly(L-leucine) grafted polyallylamine as a simple model of proteins, has been prepared by NCA polymerization with free amino groups of polyallylamine as an initiator.	polyleucine	26-41	CEA cell adhesion molecule 6	Homo sapiens	117-120
16285826-5	2005	Under acidic conditions, where electrostatic repulsion existed between the neighboring protonated amine moieties of the polyallylamine main chain, the rapid aggregation of the poly(l-leucine) graft chains was disturbed, and the peptide graft chains formed a beta-sheet structure owing to the intramolecular hydrogen bonding among the graft chains.	polyleucine	176-191	amyloid beta precursor protein	Homo sapiens	256-262
16285826-7	2005	On the other hand, under basic conditions, the poly(L-leucine) graft chains showed conformational transitions from a beta-sheet structure to an alpha-helical conformation owing to a distortion of the regular arrangement of the peptide graft chains by the conformational change of the polyallylamine main chain, whose amino groups were deprotonated.	polyleucine	47-62	amyloid beta precursor protein	Homo sapiens	115-121
8996637-0	1996	Characterization of poly-leucine substituted analogues of the human surfactant protein SP-C.	polyleucine	20-32	surfactant protein C	Homo sapiens	87-91