PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27612769-3	2016	The results showed that DLC films with a low ratio of sp(2)/sp(3), which tend to have a structure similar to that of diamond, led to less inflammatory, excellent osteogenic and fibroblastic reactions, with higher cell viability, better morphology, lower release of TNF-alpha (tumor necrosis factor-alpha) and IL-6 (interleukin-6), and higher release of IL-10 (interleukin-10).	sp(2)	54-59	tumor necrosis factor	Homo sapiens	265-274
27612769-3	2016	The results showed that DLC films with a low ratio of sp(2)/sp(3), which tend to have a structure similar to that of diamond, led to less inflammatory, excellent osteogenic and fibroblastic reactions, with higher cell viability, better morphology, lower release of TNF-alpha (tumor necrosis factor-alpha) and IL-6 (interleukin-6), and higher release of IL-10 (interleukin-10).	sp(2)	54-59	tumor necrosis factor	Homo sapiens	276-303
27612769-3	2016	The results showed that DLC films with a low ratio of sp(2)/sp(3), which tend to have a structure similar to that of diamond, led to less inflammatory, excellent osteogenic and fibroblastic reactions, with higher cell viability, better morphology, lower release of TNF-alpha (tumor necrosis factor-alpha) and IL-6 (interleukin-6), and higher release of IL-10 (interleukin-10).	sp(2)	54-59	interleukin 6	Homo sapiens	309-313
27612769-3	2016	The results showed that DLC films with a low ratio of sp(2)/sp(3), which tend to have a structure similar to that of diamond, led to less inflammatory, excellent osteogenic and fibroblastic reactions, with higher cell viability, better morphology, lower release of TNF-alpha (tumor necrosis factor-alpha) and IL-6 (interleukin-6), and higher release of IL-10 (interleukin-10).	sp(2)	54-59	interleukin 6	Homo sapiens	315-328
27612769-3	2016	The results showed that DLC films with a low ratio of sp(2)/sp(3), which tend to have a structure similar to that of diamond, led to less inflammatory, excellent osteogenic and fibroblastic reactions, with higher cell viability, better morphology, lower release of TNF-alpha (tumor necrosis factor-alpha) and IL-6 (interleukin-6), and higher release of IL-10 (interleukin-10).	sp(2)	54-59	interleukin 10	Homo sapiens	353-358
27612769-3	2016	The results showed that DLC films with a low ratio of sp(2)/sp(3), which tend to have a structure similar to that of diamond, led to less inflammatory, excellent osteogenic and fibroblastic reactions, with higher cell viability, better morphology, lower release of TNF-alpha (tumor necrosis factor-alpha) and IL-6 (interleukin-6), and higher release of IL-10 (interleukin-10).	sp(2)	54-59	interleukin 10	Homo sapiens	360-374
27016454-8	2016	We also find that for HCN trimerization, although the planar sp(2) six-membered ring is more stable compared to its monomers, the reverse is true for the nonplanar sp(3) six-membered rings formed by trimerization of formamidic acid or formamide.	sp(2)	61-66	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	22-25
26172528-1	2015	The two MeCN ligands in [Ru(2-C6H4-2"-Py-kappaC,N)(Phen, trans-C)(MeCN)2]PF6 (1), both trans to a sp(2) hybridized N atom, cannot be substituted by any other ligand.	sp(2)	98-103	sperm associated antigen 17	Homo sapiens	73-76
27486831-2	2016	These structures often differ at the C3a position, which may be substituted with an oxygen, nitrogen, or sp(3)- or sp(2)-hybridized carbon.	sp(2)	115-120	endogenous retrovirus group K member 2	Homo sapiens	37-40
27453399-0	2016	Tn Antigen Mimics Based on sp(2)-Iminosugars with Affinity for an anti-MUC1 Antibody.	sp(2)	27-32	mucin 1, cell surface associated	Homo sapiens	71-75
26332921-8	2015	Concomitant with the reduction in nN   pi* delocalization energy, the sp(2) hybrid orbital of the carbonyl carbon becomes richer in p-character, suggesting the syn configuration causes the carbonyl carbon hybrid orbitals to adopt a geometry reminiscent of a tetrahedral-like intermediate.	sp(2)	70-75	synemin	Homo sapiens	160-163
23546219-4	2013	The CASH method combines the advantages of the soft and hard template methods by employing a diblock copolymer, PI-b-PEO, which contains a hydrophilic block and an sp(2)-hybridized-carbon-containing hydrophobic block as a structure-directing agent.	sp(2)	164-169	CASP8 and FADD like apoptosis regulator	Homo sapiens	4-8
21414781-2	2011	In general, reported CRF(1) receptor antagonists possess a sp(2)-nitrogen atom as hydrogen bonding acceptor (HBA) on their core scaffolds.	sp(2)	59-64	corticotropin releasing hormone receptor 1	Mus musculus	21-36
21414781-3	2011	We proposed to use a carbonyl group of pyrrolo[2,3-d]pyrimidin-4-one derivatives as a replacement for the sp(2)-nitrogen atom as HBA in classical CRF(1) receptor antagonists.	sp(2)	106-111	corticotropin releasing hormone receptor 1	Mus musculus	146-161
12186556-8	2002	Similar experiments with Cinn-GEE that had been labeled with (13)C at the benzylic position revealed a change in the hybridization state (from sp(2) to sp(3)) for the benzylic carbon as a result of binding to PTP1B.	sp(2)	143-148	CINN	Homo sapiens	25-29
12186556-8	2002	Similar experiments with Cinn-GEE that had been labeled with (13)C at the benzylic position revealed a change in the hybridization state (from sp(2) to sp(3)) for the benzylic carbon as a result of binding to PTP1B.	sp(2)	143-148	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	209-214
10639284-2	1999	The data reveal a remarkable potency enhancement in those compounds that contain an sp(2) center at the C-4 carbon of the ring relative to similar, saturated compounds.	sp(2)	84-89	complement C4A (Rodgers blood group)	Homo sapiens	104-107
20572170-1	2010	High-spin organic structures can be obtained from fused polycyclic hydrocarbons, by converting selected peripheral HC(sp(2)) sites into H(2)C(sp(3)) ones, guided by Ovchinnikov"s rule.	sp(2)	118-123	spindlin 1	Homo sapiens	5-9
19621084-7	2009	Crystal structures of the TTR:inhibitor complexes, in agreement with molecular docking studies, revealed that the aromatic moiety, linked to the sp(2)-hybridized oxime carbon, specifically directed the ligand in either a forward or reverse binding mode.	sp(2)	145-150	transthyretin	Homo sapiens	26-29
18998731-1	2008	DFT calculations support a concerted mechanism for xanthine oxidase and aldehyde oxidase hydride displacement from the sp(2) carbon of 6-substituted 4-quinazolinones.	sp(2)	119-124	aldehyde oxidase 1	Homo sapiens	72-88
12691566-5	2003	Protonation with CF(3)SO(3)H acid occurs at the sp(2) nitrogen to give [PhN-(H) HC(C(3)F(7))-C(C(3)F(7))-NHPh][CF(3)SO(3)].	sp(2)	48-53	carbamoyl-phosphate synthase 1	Homo sapiens	72-75
21619081-7	1996	For the five biphasic solvent systems studied, linear relationships were found between the partition coefficients and the sp(3) and sp(2) hybridized carbon atom number for the alkylbenzene and PAH series, respectively.	sp(2)	132-137	phenylalanine hydroxylase	Homo sapiens	193-196