PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
17958425-0	2007	The natural product avrainvillamide binds to the oncoprotein nucleophosmin.	avrainvillamide	20-35	nucleophosmin 1	Homo sapiens	61-74
17958425-1	2007	Here we present evidence that (+)-avrainvillamide, a naturally occurring alkaloid with antiproliferative effects, binds to the nuclear chaperone nucleophosmin, a proposed oncogenic protein that is overexpressed in many different human tumors.	avrainvillamide	30-49	nucleophosmin 1	Homo sapiens	145-158
17958425-4	2007	Affinity-isolation of nucleophosmin was inhibited in the presence of iodoacetamide (10 mM), free (+)-avrainvillamide (100 microM), and a series of closely related structural analogues of (+)-avrainvillamide, the latter with inhibitory effects that appear to correlate with measured growth-inhibitory potencies.	avrainvillamide	97-116	nucleophosmin 1	Homo sapiens	22-35
17958425-4	2007	Affinity-isolation of nucleophosmin was inhibited in the presence of iodoacetamide (10 mM), free (+)-avrainvillamide (100 microM), and a series of closely related structural analogues of (+)-avrainvillamide, the latter with inhibitory effects that appear to correlate with measured growth-inhibitory potencies.	avrainvillamide	187-206	nucleophosmin 1	Homo sapiens	22-35
17958425-6	2007	Site-directed mutagenesis of each of the three cysteine residues of a truncated nucleophosmin coexpressed with native nucleophosmin in COS-7 cells revealed that the mutation cys275 --> ala275 effectively and uniquely reduced affinity-isolation of the truncated protein, suggesting that avrainvillamide targets cys275 of nucleophosmin.	avrainvillamide	289-304	nucleophosmin 1	Homo sapiens	80-93
17958425-7	2007	Finally, we show that treatment of adhered LNCaP or T-47D cells with (+)-avrainvillamide leads to an increase in cellular p53 concentrations, and that siRNA-promoted depletion of nucleophosmin in a population of HeLa S3 cells leads to increased sensitivity of that population toward apoptotic death upon treatment with (+)-avrainvillamide.	avrainvillamide	69-88	tumor protein p53	Homo sapiens	122-125
17958425-7	2007	Finally, we show that treatment of adhered LNCaP or T-47D cells with (+)-avrainvillamide leads to an increase in cellular p53 concentrations, and that siRNA-promoted depletion of nucleophosmin in a population of HeLa S3 cells leads to increased sensitivity of that population toward apoptotic death upon treatment with (+)-avrainvillamide.	avrainvillamide	319-338	nucleophosmin 1	Homo sapiens	179-192
25531824-5	2015	Immunofluorescence and mass spectrometric experiments employing a series of different NPM1 constructs suggest that a specific interaction between avrainvillamide and Cys275 of certain NPM1 mutants mediates the relocalization of these proteins to the nucleolus.	avrainvillamide	146-161	nucleophosmin 1	Homo sapiens	86-90
25531824-5	2015	Immunofluorescence and mass spectrometric experiments employing a series of different NPM1 constructs suggest that a specific interaction between avrainvillamide and Cys275 of certain NPM1 mutants mediates the relocalization of these proteins to the nucleolus.	avrainvillamide	146-161	nucleophosmin 1	Homo sapiens	184-188
25531824-6	2015	Avrainvillamide treatment is also shown to inhibit nuclear export of Crm1 cargo proteins, including AML-associated NPM1 mutants.	avrainvillamide	0-15	exportin 1	Homo sapiens	69-73
25531824-6	2015	Avrainvillamide treatment is also shown to inhibit nuclear export of Crm1 cargo proteins, including AML-associated NPM1 mutants.	avrainvillamide	0-15	nucleophosmin 1	Homo sapiens	115-119
25531824-7	2015	We also observe that avrainvillamide treatment displaces Thr199-phosphorylated NPM1 from duplicated centrosomes, leads to an accumulation of supernumerary centrosomes, and inhibits dephosphorylation of Thr199-phosphorylated NPM1 by protein phosphatase 1.	avrainvillamide	21-36	nucleophosmin 1	Homo sapiens	79-83
25531824-7	2015	We also observe that avrainvillamide treatment displaces Thr199-phosphorylated NPM1 from duplicated centrosomes, leads to an accumulation of supernumerary centrosomes, and inhibits dephosphorylation of Thr199-phosphorylated NPM1 by protein phosphatase 1.	avrainvillamide	21-36	nucleophosmin 1	Homo sapiens	224-228
25531824-8	2015	Avrainvillamide is the first small molecule reported to relocalize specific cytoplasmic AML-associated NPM1 mutants to the nucleolus, providing an important demonstration of principle that small molecule induction of a wild-type NPM1 localization phenotype is feasible in certain human cancer cells.	avrainvillamide	0-15	nucleophosmin 1	Homo sapiens	103-107
25531824-8	2015	Avrainvillamide is the first small molecule reported to relocalize specific cytoplasmic AML-associated NPM1 mutants to the nucleolus, providing an important demonstration of principle that small molecule induction of a wild-type NPM1 localization phenotype is feasible in certain human cancer cells.	avrainvillamide	0-15	nucleophosmin 1	Homo sapiens	229-233
27906185-0	2016	Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia.	avrainvillamide	68-83	nucleophosmin 1	Homo sapiens	35-39
27906185-2	2016	Here we examined the in vitro and in vivo anti-leukemic activity of the NPM1 and chromosome region maintenance 1 homolog (CRM1) interacting natural product avrainvillamide (AVA) and a fully syntetic AVA analog.	avrainvillamide	156-171	nucleophosmin 1	Homo sapiens	72-76
27906185-2	2016	Here we examined the in vitro and in vivo anti-leukemic activity of the NPM1 and chromosome region maintenance 1 homolog (CRM1) interacting natural product avrainvillamide (AVA) and a fully syntetic AVA analog.	avrainvillamide	156-171	exportin 1	Homo sapiens	122-126
27906185-2	2016	Here we examined the in vitro and in vivo anti-leukemic activity of the NPM1 and chromosome region maintenance 1 homolog (CRM1) interacting natural product avrainvillamide (AVA) and a fully syntetic AVA analog.	avrainvillamide	173-176	exportin 1	Homo sapiens	122-126
27906185-6	2016	AVA treatment induced nuclear retention of the NPM1 mutant protein (NPMc+) in OCI-AML3 cells and primary AML cells, caused proteasomal degradation of NPMc+ and the nuclear export factor CRM1 and downregulated wt FLT3 protein.	avrainvillamide	0-3	nucleophosmin 1	Homo sapiens	47-51
27906185-6	2016	AVA treatment induced nuclear retention of the NPM1 mutant protein (NPMc+) in OCI-AML3 cells and primary AML cells, caused proteasomal degradation of NPMc+ and the nuclear export factor CRM1 and downregulated wt FLT3 protein.	avrainvillamide	0-3	exportin 1	Homo sapiens	186-190
27906185-6	2016	AVA treatment induced nuclear retention of the NPM1 mutant protein (NPMc+) in OCI-AML3 cells and primary AML cells, caused proteasomal degradation of NPMc+ and the nuclear export factor CRM1 and downregulated wt FLT3 protein.	avrainvillamide	0-3	fms related receptor tyrosine kinase 3	Homo sapiens	212-216
25531824-0	2015	Interactions of the natural product (+)-avrainvillamide with nucleophosmin and exportin-1 Mediate the cellular localization of nucleophosmin and its AML-associated mutants.	avrainvillamide	36-55	nucleophosmin 1	Homo sapiens	61-74
25531824-0	2015	Interactions of the natural product (+)-avrainvillamide with nucleophosmin and exportin-1 Mediate the cellular localization of nucleophosmin and its AML-associated mutants.	avrainvillamide	36-55	exportin 1	Homo sapiens	79-89
25531824-0	2015	Interactions of the natural product (+)-avrainvillamide with nucleophosmin and exportin-1 Mediate the cellular localization of nucleophosmin and its AML-associated mutants.	avrainvillamide	36-55	nucleophosmin 1	Homo sapiens	127-140
25531824-3	2015	We have previously shown that the electrophilic antiproliferative natural product (+)-avrainvillamide (1) binds to proteins, including nucleophosmin, by S-alkylation of cysteine residues.	avrainvillamide	82-101	nucleophosmin 1	Homo sapiens	135-148
25531824-4	2015	Here, we report that avrainvillamide restores nucleolar localization of certain AML-associated mutant forms of NPM1 and provide evidence that this relocalization is mediated by interactions of avrainvillamide with mutant NPM1 and exportin-1 (Crm1).	avrainvillamide	21-36	nucleophosmin 1	Homo sapiens	111-115