PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28040899-3	2017	Various substrates including the natural product alangiobussinine and the marinacarboline core structure were functionalized using carboline-directed delta-C(sp2)-H alkynylations.	Carbolines	80-89	Sp2 transcription factor	Homo sapiens	156-161
27934367-0	2016	Intramolecular Csp2-Csp2 Friedel-Crafts Arylation: Substrate- and Condition-Controlled Divergent Synthesis of Fused-beta-carbolines.	Carbolines	115-131	regulator of calcineurin 2	Homo sapiens	15-19
27934367-0	2016	Intramolecular Csp2-Csp2 Friedel-Crafts Arylation: Substrate- and Condition-Controlled Divergent Synthesis of Fused-beta-carbolines.	Carbolines	115-131	regulator of calcineurin 2	Homo sapiens	20-24
27934367-1	2016	A triple cooperative catalysis-mediated multicomponent reaction between 1-formyl-N-substituted-beta-carbolines, a terminal alkyne, and a secondary amine allows access to unprecedented polycyclic beta-carbolines via sequential A3-coupling and an intramolecular Csp2-Csp2 Friedel-Crafts arylation reaction.	Carbolines	95-110	regulator of calcineurin 2	Homo sapiens	260-264
27934367-1	2016	A triple cooperative catalysis-mediated multicomponent reaction between 1-formyl-N-substituted-beta-carbolines, a terminal alkyne, and a secondary amine allows access to unprecedented polycyclic beta-carbolines via sequential A3-coupling and an intramolecular Csp2-Csp2 Friedel-Crafts arylation reaction.	Carbolines	95-110	regulator of calcineurin 2	Homo sapiens	265-269
27230395-6	2016	The mechanisms responsible for the anti-addictive properties of ayahuasca and its alkaloids are not clarified, apparently involving both peripheral MAO-A inhibition by the beta-carbolines and central agonism of DMT at 5-HT2A receptors expressed in brain regions related to the regulation of mood and emotions.	Carbolines	172-187	monoamine oxidase A	Homo sapiens	148-153
27226119-0	2016	Visible Light Driven Photocascade Catalysis: Ru(bpy)3(PF6)2/TBHP-Mediated Synthesis of Fused beta-Carbolines in Batch and Flow Microreactors.	Carbolines	93-108	sperm associated antigen 17	Homo sapiens	54-57
26583324-0	2015	Novel beta-carbolines inhibit Wnt/beta-catenin signaling.	Carbolines	6-21	catenin beta 1	Homo sapiens	34-46
25770611-0	2015	Biosensor based on inhibition of monoamine oxidases A and B for detection of beta-carbolines.	Carbolines	77-92	monoamine oxidase A	Homo sapiens	33-59
27551464-0	2015	Novel beta-carbolines against colorectal cancer cell growth via inhibition of Wnt/beta-catenin signaling.	Carbolines	6-21	catenin beta 1	Homo sapiens	82-94
26192590-0	2015	Selectivity Profiling and Biological Activity of Novel beta-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors.	Carbolines	55-70	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	95-100
25770611-7	2015	The presence of norharmane in mixtures of beta-carbolines can be identified based on the difference between the cumulative inhibition of MAO-A by all beta-carbolines and MAO-B inhibition.	Carbolines	42-57	monoamine oxidase A	Homo sapiens	137-142
25770611-7	2015	The presence of norharmane in mixtures of beta-carbolines can be identified based on the difference between the cumulative inhibition of MAO-A by all beta-carbolines and MAO-B inhibition.	Carbolines	42-57	monoamine oxidase B	Homo sapiens	170-175
25770611-1	2015	beta-Carbolines are inhibitors of monoamine oxidases (MAO-A and MAO-B) and can be found in foods, hallucinogenic plant or various drugs.	Carbolines	0-15	monoamine oxidase A	Homo sapiens	54-59
25770611-7	2015	The presence of norharmane in mixtures of beta-carbolines can be identified based on the difference between the cumulative inhibition of MAO-A by all beta-carbolines and MAO-B inhibition.	Carbolines	150-165	monoamine oxidase A	Homo sapiens	137-142
25770611-1	2015	beta-Carbolines are inhibitors of monoamine oxidases (MAO-A and MAO-B) and can be found in foods, hallucinogenic plant or various drugs.	Carbolines	0-15	monoamine oxidase B	Homo sapiens	64-69
25770611-6	2015	The MAO-A is inhibited by all three tested beta-carbolines (harmane, norharmane, and harmaline) while MAO-B is inhibited only by norharmane.	Carbolines	43-58	monoamine oxidase A	Homo sapiens	4-9
25498864-3	2015	Previous literature indicates that certain beta-carbolines including harmane modulate central monoamine levels partly through monoamine oxidase (MAO) inhibition.	Carbolines	43-58	monoamine oxidase A	Rattus norvegicus	126-143
25498864-3	2015	Previous literature indicates that certain beta-carbolines including harmane modulate central monoamine levels partly through monoamine oxidase (MAO) inhibition.	Carbolines	43-58	monoamine oxidase A	Rattus norvegicus	145-148
22425563-5	2012	The result of inhibition in human-AChE of serotonin, beta-carbolines and quinolines showed similar profile as eel-AChE with lower magnitude.	Carbolines	53-68	acetylcholinesterase (Cartwright blood group)	Homo sapiens	34-38
25240617-0	2014	Computational & experimental evaluation of the structure/activity relationship of beta-carbolines as DYRK1A inhibitors.	Carbolines	86-101	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	105-111
24373881-0	2014	Inhibition of monoamine oxidase (MAO) by beta-carbolines and their interactions in live neuronal (PC12) and liver (HuH-7 and MH1C1) cells.	Carbolines	41-56	monoamine oxidase A	Rattus norvegicus	14-31
24373881-0	2014	Inhibition of monoamine oxidase (MAO) by beta-carbolines and their interactions in live neuronal (PC12) and liver (HuH-7 and MH1C1) cells.	Carbolines	41-56	monoamine oxidase A	Rattus norvegicus	33-36
24373881-4	2014	Using kynuramine assays, intracellular MAO inhibition by beta-carbolines was measured in PC12 (rat pheochromocytoma), MH1C1 (rat liver), and HuH-7 (human liver) cell lines, which were compared with human recombinant MAO and cell lysates.	Carbolines	57-72	monoamine oxidase A	Rattus norvegicus	39-42
24373881-4	2014	Using kynuramine assays, intracellular MAO inhibition by beta-carbolines was measured in PC12 (rat pheochromocytoma), MH1C1 (rat liver), and HuH-7 (human liver) cell lines, which were compared with human recombinant MAO and cell lysates.	Carbolines	57-72	MIR7-3 host gene	Homo sapiens	141-146
24373881-5	2014	beta-Carbolines (1 muM, 90 min incubations) inhibited MAO by 40-99% in live PC12 cells where MAO A was the active isoform, and <12% in HuH-7 and MH1C1 cells where MAO B was primarily active.	Carbolines	0-15	latexin	Homo sapiens	19-22
24373881-5	2014	beta-Carbolines (1 muM, 90 min incubations) inhibited MAO by 40-99% in live PC12 cells where MAO A was the active isoform, and <12% in HuH-7 and MH1C1 cells where MAO B was primarily active.	Carbolines	0-15	monoamine oxidase A	Rattus norvegicus	54-57
24373881-5	2014	beta-Carbolines (1 muM, 90 min incubations) inhibited MAO by 40-99% in live PC12 cells where MAO A was the active isoform, and <12% in HuH-7 and MH1C1 cells where MAO B was primarily active.	Carbolines	0-15	monoamine oxidase A	Rattus norvegicus	93-98
24373881-5	2014	beta-Carbolines (1 muM, 90 min incubations) inhibited MAO by 40-99% in live PC12 cells where MAO A was the active isoform, and <12% in HuH-7 and MH1C1 cells where MAO B was primarily active.	Carbolines	0-15	MIR7-3 host gene	Homo sapiens	138-143
24373881-5	2014	beta-Carbolines (1 muM, 90 min incubations) inhibited MAO by 40-99% in live PC12 cells where MAO A was the active isoform, and <12% in HuH-7 and MH1C1 cells where MAO B was primarily active.	Carbolines	0-15	monoamine oxidase B	Rattus norvegicus	166-171
21992679-5	2012	Clorgyline and the beta-carbolines, harman and norharman, inhibited the oxidation of MPTP by MAO-A.	Carbolines	19-34	monoamine oxidase A	Homo sapiens	93-98
21992679-6	2012	Cigarette smoke, as well as the naturally occurring beta-carbolines (norharman and harman) isolated from smoke and coffee inhibited the oxidation of MPTP by MAO-B and/or MAO-A, suggesting protective effects against MPTP.	Carbolines	52-67	monoamine oxidase B	Homo sapiens	157-162
21992679-6	2012	Cigarette smoke, as well as the naturally occurring beta-carbolines (norharman and harman) isolated from smoke and coffee inhibited the oxidation of MPTP by MAO-B and/or MAO-A, suggesting protective effects against MPTP.	Carbolines	52-67	monoamine oxidase A	Homo sapiens	170-175
22717507-1	2012	The natural indole alkaloids, the beta-carbolines, are often associated with cholinesterase inhibition, especially their quaternary salts, which frequently have higher activity than the free bases.	Carbolines	34-49	butyrylcholinesterase	Homo sapiens	77-91
22335895-2	2012	High throughput screening of approximately 140,000 compounds identified the beta-carbolines harmine and harmol as moderately potent haspin kinase inhibitors.	Carbolines	76-91	histone H3 associated protein kinase	Mus musculus	132-138
20641293-6	2004	HAR is a carboline analog, which is a competitive and reversible inhibitor of MAO-A with a Ki of 5 nM (6).	Carbolines	9-18	monoamine oxidase A	Homo sapiens	78-83
22165909-2	2012	Substitutions to the carboline cap group were well-tolerated with substitution at the 2-position of both beta- and gamma-carbolines being optimal for HDAC6 activity and selectivity.	Carbolines	21-30	histone deacetylase 6	Homo sapiens	150-155
21816955-4	2011	The five beta-carbolines that we tested, which possess a pyridinium-like structure and are structurally related to the neurotoxin 1-methyl-4-phenylpyridinium, inhibited PMAT with high affinity (IC(50) values of 39.1-65.5 muM).	Carbolines	9-24	solute carrier family 29 member 4	Homo sapiens	169-173
21816955-5	2011	Cytotoxicity analysis further showed that cells expressing PMAT are 14- to 15-fold more sensitive to harmalan and norharmanium, suggesting that these two beta-carbolines are also transportable substrates of PMAT.	Carbolines	154-169	solute carrier family 29 member 4	Homo sapiens	59-63
21816955-5	2011	Cytotoxicity analysis further showed that cells expressing PMAT are 14- to 15-fold more sensitive to harmalan and norharmanium, suggesting that these two beta-carbolines are also transportable substrates of PMAT.	Carbolines	154-169	solute carrier family 29 member 4	Homo sapiens	207-211
20036304-10	2010	The potent inhibition of MAO-A by seed and root extracts of P. harmala containing beta-carbolines should contribute to the psychopharmacological and toxicological effects of this plant and could be the basis for its purported antidepressant actions.	Carbolines	82-97	monoamine oxidase A	Homo sapiens	25-30
21256758-0	2011	Synthesis of carbon-11-labeled bivalent beta-carbolines as new PET agents for imaging of cholinesterase in Alzheimer"s disease.	Carbolines	40-55	butyrylcholinesterase	Homo sapiens	89-103
20449727-6	2010	The AhR-activating property of the beta-carbolines is completely abrogated in AhR-deficient cells providing evidence that rutaecarpine, annomontine and xestomanzamine A are natural stimulators of the human AhR.	Carbolines	35-50	aryl hydrocarbon receptor	Homo sapiens	4-7
20449727-6	2010	The AhR-activating property of the beta-carbolines is completely abrogated in AhR-deficient cells providing evidence that rutaecarpine, annomontine and xestomanzamine A are natural stimulators of the human AhR.	Carbolines	35-50	aryl hydrocarbon receptor	Homo sapiens	78-81
20449727-6	2010	The AhR-activating property of the beta-carbolines is completely abrogated in AhR-deficient cells providing evidence that rutaecarpine, annomontine and xestomanzamine A are natural stimulators of the human AhR.	Carbolines	35-50	aryl hydrocarbon receptor	Homo sapiens	78-81
20885009-2	2010	Several beta-carbolines inhibited platelet aggregation induced by collagen, epinephrine, adenosine 5"-diphosphate, platelet-activating factor and thrombin.	Carbolines	8-23	coagulation factor II, thrombin	Homo sapiens	146-154
20361801-5	2010	While connecting beta-carboline units by alkylene spacers in two different series of compounds and subsequent evaluation of their AChE/BChE-inhibitory potential, we found that several of these bivalent beta-carbolines were potent NR blockers.	Carbolines	202-217	acetylcholinesterase (Cartwright blood group)	Homo sapiens	130-134
20361801-5	2010	While connecting beta-carboline units by alkylene spacers in two different series of compounds and subsequent evaluation of their AChE/BChE-inhibitory potential, we found that several of these bivalent beta-carbolines were potent NR blockers.	Carbolines	202-217	butyrylcholinesterase	Homo sapiens	135-139
20206015-4	2010	In addition, tadalafil analogues that were synthesized from l-tryptophan were more active than those derived from d-tryptophan, which is of economic value and expands the horizon for the discovery of new carbolines as PDE5 inhibitors.	Carbolines	204-214	phosphodiesterase 5A	Homo sapiens	218-222
19619142-2	2009	The present study screened four structurally similar beta-carbolines, 1,2,3,4-tetrahydronorharmane, norharmane, harmane and 6-methoxyharmalan, at recombinantly expressed alpha1, alpha1beta, alpha2 and alpha3 glycine receptors with the aims of identifying structural elements of both the receptor and the compounds that are important for binding and subunit specificity.	Carbolines	53-68	adrenoceptor alpha 1D	Homo sapiens	170-188
17692827-0	2007	Cytotoxicity of beta-carbolines in dopamine transporter expressing cells: structure-activity relationships.	Carbolines	16-31	solute carrier family 6 member 3	Homo sapiens	35-55
19119997-0	2009	Structural analysis of carboline derivatives as inhibitors of MAPKAP K2 using 3D QSAR and docking studies.	Carbolines	23-32	MAPK activated protein kinase 2	Homo sapiens	62-71
19119997-9	2009	The structure activity relationships elucidated here for carboline derivatives combined with their binding information will provide an integrated approach to explore the chemical space further for improving the potency of MAPKAPK2 inhibitors.	Carbolines	57-66	MAPK activated protein kinase 2	Homo sapiens	222-230
18672028-14	2008	Insulin is potent in this effect; IC(50) of insulin was found to be about 4.3 x 10(-10) M. The insulin effect on the GABA dose responses looked like that of an antagonist similar to bicuculline or beta-carbolines.	Carbolines	197-212	insulin	Homo sapiens	0-7
18672028-14	2008	Insulin is potent in this effect; IC(50) of insulin was found to be about 4.3 x 10(-10) M. The insulin effect on the GABA dose responses looked like that of an antagonist similar to bicuculline or beta-carbolines.	Carbolines	197-212	insulin	Homo sapiens	44-51
18672028-14	2008	Insulin is potent in this effect; IC(50) of insulin was found to be about 4.3 x 10(-10) M. The insulin effect on the GABA dose responses looked like that of an antagonist similar to bicuculline or beta-carbolines.	Carbolines	197-212	insulin	Homo sapiens	95-102
18262425-4	2008	Delta-carbolines 3 and 4 showed better affinity than the corresponding beta-carbolines 1 and 2, respectively, while N-methylation (2, 4, and 6, respectively) of the pyrrole ring in 1, 3, and 5 resulted in the reduced affinity to the adenosine A(3) receptor.	Carbolines	71-86	adenosine A3 receptor	Homo sapiens	233-256
17883257-8	2007	beta-Carbolines were isolated from raisins and acted as good competitive inhibitors of MAO-A (harman) and MAO-B (norharman) isozymes.	Carbolines	0-15	monoamine oxidase A	Homo sapiens	87-92
17883257-8	2007	beta-Carbolines were isolated from raisins and acted as good competitive inhibitors of MAO-A (harman) and MAO-B (norharman) isozymes.	Carbolines	0-15	monoamine oxidase B	Homo sapiens	106-111
17583514-1	2007	beta-Carbolines stimulate insulin secretion in a glucose-dependent manner, probably by acting on I(3)-binding site.	Carbolines	0-15	insulin	Homo sapiens	26-33
15480838-10	2004	Various endogenous and exogenous heterocyclic molecules, which are structurally related to MPTP/MPP(+), such as isoquinolines and beta-carbolines, have been reported to exhibit similar toxic properties on DA cells, which are conferred by their uptake by the DAT.	Carbolines	130-145	solute carrier family 6 member 3	Homo sapiens	258-261
16870220-8	2006	In contrast, various beta-carbolines were efficiently hydroxylated to hydroxy-beta-carbolines by CYP2D6.	Carbolines	21-36	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	97-103
16870220-12	2006	Altogether, these results suggest that CYP2D6 can play an important role in the metabolic outcome of both MPTP and beta-carbolines.	Carbolines	115-130	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	39-45
16061219-1	2005	This study was designed to determine the affinity and binding profile of beta-carbolines for imidazoline I2 receptors and catalytic sites of monoamine oxidase (MAO)-A/B in rat brain and liver.	Carbolines	73-88	monoamine oxidase A	Rattus norvegicus	141-166
16061219-5	2005	In brain and liver, competition curves for beta-carbolines against [3H]Ro41-1049 (MAO-A) and [3H]Ro19-6327 (MAO-B) were monophasic and resulted in different drug potencies for the two MAO isozymes (higher affinities for MAO-A) and in similar pharmacological profiles in both tissues.	Carbolines	43-58	monoamine oxidase A	Rattus norvegicus	82-87
16061219-5	2005	In brain and liver, competition curves for beta-carbolines against [3H]Ro41-1049 (MAO-A) and [3H]Ro19-6327 (MAO-B) were monophasic and resulted in different drug potencies for the two MAO isozymes (higher affinities for MAO-A) and in similar pharmacological profiles in both tissues.	Carbolines	43-58	monoamine oxidase B	Rattus norvegicus	108-113
16061219-5	2005	In brain and liver, competition curves for beta-carbolines against [3H]Ro41-1049 (MAO-A) and [3H]Ro19-6327 (MAO-B) were monophasic and resulted in different drug potencies for the two MAO isozymes (higher affinities for MAO-A) and in similar pharmacological profiles in both tissues.	Carbolines	43-58	monoamine oxidase A	Rattus norvegicus	82-85
16061219-5	2005	In brain and liver, competition curves for beta-carbolines against [3H]Ro41-1049 (MAO-A) and [3H]Ro19-6327 (MAO-B) were monophasic and resulted in different drug potencies for the two MAO isozymes (higher affinities for MAO-A) and in similar pharmacological profiles in both tissues.	Carbolines	43-58	monoamine oxidase A	Rattus norvegicus	220-225
16356849-1	2005	Mana-Hox, an analog of beta-carbolines with anticancer activity, induces aberrant mitosis and delays mitotic exit.	Carbolines	23-38	mannosidase alpha class 2C member 1	Homo sapiens	0-4
14660022-7	2003	The results reveal that beta-carbolines can potentiate the rate of insulin secretion from human islets and suggest that these agents may be useful prototypes for the development of novel insulin secretagogues.	Carbolines	24-39	insulin	Homo sapiens	67-74
15262334-0	2004	The strong inhibition of triosephosphate isomerase by the natural beta-carbolines may explain their neurotoxic actions.	Carbolines	66-81	triosephosphate isomerase 1	Homo sapiens	25-50
15262334-3	2004	Utilizing [3H]BC, we have identified several proteins to which BC binds with high affinity (e.g. the chaperone member glucose regulated protein 78, the enzyme carboxylesterase, the cytochrome P450 2E1, the enzyme monoamine oxidase B and a small G-protein of the Rho subfamily).	Carbolines	14-16	monoamine oxidase B	Homo sapiens	213-232
15262334-4	2004	In the present study we isolated a protein from bovine brain to which [3H]BC binds with high affinity and identified it being the enzyme triosephosphate isomerase (TPI; EC 5.3.1.1.).	Carbolines	74-76	triosephosphate isomerase 1	Bos taurus	137-162
15262334-4	2004	In the present study we isolated a protein from bovine brain to which [3H]BC binds with high affinity and identified it being the enzyme triosephosphate isomerase (TPI; EC 5.3.1.1.).	Carbolines	74-76	triosephosphate isomerase 1	Bos taurus	164-167
14660022-0	2003	Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans.	Carbolines	15-30	insulin	Homo sapiens	57-64
14660022-2	2003	Recently, it has been proposed that beta-carbolines may be endogenous ligands having activity at imidazoline sites and we have, therefore, studied the effects of beta-carbolines on insulin secretion.	Carbolines	162-177	insulin	Homo sapiens	181-188
14660022-7	2003	The results reveal that beta-carbolines can potentiate the rate of insulin secretion from human islets and suggest that these agents may be useful prototypes for the development of novel insulin secretagogues.	Carbolines	24-39	insulin	Homo sapiens	187-194
14660022-3	2003	The beta-carbolines harmane, norharmane and pinoline increased insulin secretion two- to threefold from isolated human islets of Langerhans.	Carbolines	4-19	insulin	Homo sapiens	63-70
11909733-3	2002	While most beta-carbolines inhibited CDK2 and CDK5 to the same extent, selective inhibition against CDK2 was observed in 1-(2-chlorophenyl)- (12), 1-(2-fluorophenyl)- (15), and 1-(2-chloro-5-nitrophenyl)- (28) beta-carbolines.	Carbolines	11-26	cyclin dependent kinase 2	Homo sapiens	37-41
15028583-9	2003	Thus, beta-carbolines represent a new class of insulin secretagogues, although it remains unclear whether their action is mediated solely by I(3) sites in the beta cell.	Carbolines	6-21	insulin	Homo sapiens	47-54
14568301-1	2003	This study investigated the inhibitory effect of 9H-pyrido[3,4-b]indole (norharman), one of the naturally occurring beta-carbolines, on cytochrome P450 (CYP)-related activities and the relationship between its inhibitory effect, its intercalation to DNA, and its comutagenic effect.	Carbolines	116-131	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	136-151
14568301-1	2003	This study investigated the inhibitory effect of 9H-pyrido[3,4-b]indole (norharman), one of the naturally occurring beta-carbolines, on cytochrome P450 (CYP)-related activities and the relationship between its inhibitory effect, its intercalation to DNA, and its comutagenic effect.	Carbolines	116-131	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	153-156
14568301-8	2003	Norharman"s inhibition of CYP and its enhancement of the N-OH-Glu-P-1 mutagenicity suggest that beta-carbolines modulate chemical carcinogenesis by controlling the xenobiotic metabolism and by intercalating to DNA.	Carbolines	96-111	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	26-29
12804796-3	2003	beta-Carbolines and antioxidants (superoxide dismutase, catalase, ascorbate or rutin) prevented the loss of cell viability in PC12 cells treated with 250 microM MPP(+), while the effects of N-acetylcysteine and dithiothreitol were not observed.	Carbolines	0-15	catalase	Rattus norvegicus	56-64
12804796-6	2003	beta-Carbolines (50 microM) inhibited the decrease in mitochondrial transmembrane potential, cytochrome c release, activation of caspase-3, formation of reactive oxygen species (ROS) and depletion of GSH caused by MPP(+) in PC12 cells.	Carbolines	0-15	caspase 3	Rattus norvegicus	129-138
12727306-1	2003	We have previously speculated that elevated levels of nicotinamide N-methyltransferase (NNMT), the primary catabolic enzyme of nicotinamide, may result in reduced Complex I activity in idiopathic Parkinson"s disease (IPD) in two ways: (1) reduction in the levels of nicotinamide available for nicotinamide adenine dinucleotide synthesis; and (2) increased methylation of compounds such as tetrahydroisoquinolines and beta-carbolines, which are potent Complex I inhibitors.	Carbolines	417-432	nicotinamide N-methyltransferase	Homo sapiens	54-86
12727306-1	2003	We have previously speculated that elevated levels of nicotinamide N-methyltransferase (NNMT), the primary catabolic enzyme of nicotinamide, may result in reduced Complex I activity in idiopathic Parkinson"s disease (IPD) in two ways: (1) reduction in the levels of nicotinamide available for nicotinamide adenine dinucleotide synthesis; and (2) increased methylation of compounds such as tetrahydroisoquinolines and beta-carbolines, which are potent Complex I inhibitors.	Carbolines	417-432	nicotinamide N-methyltransferase	Homo sapiens	88-92
12639576-0	2003	Synthesis and biological activities of novel beta-carbolines as PDE5 inhibitors.	Carbolines	45-60	phosphodiesterase 5A	Canis lupus familiaris	64-68
11909733-3	2002	While most beta-carbolines inhibited CDK2 and CDK5 to the same extent, selective inhibition against CDK2 was observed in 1-(2-chlorophenyl)- (12), 1-(2-fluorophenyl)- (15), and 1-(2-chloro-5-nitrophenyl)- (28) beta-carbolines.	Carbolines	11-26	cyclin dependent kinase 5	Homo sapiens	46-50
11909733-3	2002	While most beta-carbolines inhibited CDK2 and CDK5 to the same extent, selective inhibition against CDK2 was observed in 1-(2-chlorophenyl)- (12), 1-(2-fluorophenyl)- (15), and 1-(2-chloro-5-nitrophenyl)- (28) beta-carbolines.	Carbolines	11-26	cyclin dependent kinase 2	Homo sapiens	100-104
11909733-3	2002	While most beta-carbolines inhibited CDK2 and CDK5 to the same extent, selective inhibition against CDK2 was observed in 1-(2-chlorophenyl)- (12), 1-(2-fluorophenyl)- (15), and 1-(2-chloro-5-nitrophenyl)- (28) beta-carbolines.	Carbolines	210-225	cyclin dependent kinase 2	Homo sapiens	100-104
12831203-5	2002	For aminoimidazoazaarenes, the most abundant ions were derived from the loss of a methyl group and the breaking of the aminoimidazole moiety, while for carbolines the major product ions arose from the loss of ammonia and HCN.	Carbolines	152-162	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	221-224
10940539-0	2000	Binding of beta-carbolines and related agents at serotonin (5-HT(2) and 5-HT(1A)), dopamine (D(2)) and benzodiazepine receptors.	Carbolines	11-26	5-hydroxytryptamine receptor 1A	Homo sapiens	72-79
10940539-1	2000	A large series of beta-carbolines was examined for their ability to bind at [3H]agonist-labeled 5-HT(2A) serotonin receptors.	Carbolines	18-33	5-hydroxytryptamine receptor 2A	Homo sapiens	96-103
10940539-4	2000	The beta-carbolines were found to bind with modest affinity at 5-HT(2A) receptors, and affinity was highly dependent upon the presence of ring substituents and ring saturation.	Carbolines	4-19	5-hydroxytryptamine receptor 2A	Homo sapiens	63-70
10940539-7	2000	Although the only common receptor population that might account for this action is 5-HT(2A), on the basis of a lack of enhanced affinity for agonist-labeled 5-HT(2A) receptors, as well as on their lack of agonist action in the PI hydrolysis assay, it is difficult to conclude that the beta-carbolines behave in a manner consistent with that of other classical hallucinogens.	Carbolines	285-300	5-hydroxytryptamine receptor 2A	Homo sapiens	83-90
7699568-9	1994	In contrast, all the beta-carbolines investigated in this study had low potencies as inhibitors of monoamine oxidase B.	Carbolines	21-36	monoamine oxidase B	Bos taurus	99-118
10788565-5	2000	In vitro GRAB analysis has identified several imidazoline receptor ligands and beta-carbolines as AhR agonists and also revealed the presence of AhR agonist activity in crude DMSO extracts of commercial newspapers.	Carbolines	79-94	aryl hydrocarbon receptor	Homo sapiens	98-101
9534250-4	1998	A comparison with conventional matrices for carbohydrates (DHB and DHB/HIC) indicates that beta-carbolines provide the same level of sensitivity and resolution in the positive mode, but offer the advantage of high levels of sensitivity and resolution in the negative mode.	Carbolines	91-106	MyoD family inhibitor domain containing	Homo sapiens	71-74
8959985-11	1996	MAO-B is essential for the activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to 1-methyl-4-phenylpyridinium ion, for a component of the enzymatic conversion of dopamine to hydrogen peroxide (H2O2), and for the activation of other potential toxins such as isoquinolines and beta-carbolines.	Carbolines	282-297	monoamine oxidase B	Homo sapiens	0-5
7491124-5	1995	The alterations, by beta-carbolines, of some important enzymatic systems, e.g. cytochrome P-450, have been clearly demonstrated, yet many discrepancies and contradictions exist so that an interpretation of the results and the definition of some common mechanism appears premature.	Carbolines	20-35	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	79-95
1530666-3	1992	Harmaline and a number of other beta-carbolines inhibited HNMT with IC50 values in the range of 1-10 microM.	Carbolines	32-47	histamine N-methyltransferase	Rattus norvegicus	58-62
2167977-6	1990	In addition to H1 and A2, there appears to be a relatively narrow hydrophobic pocket in the binding cleft that can accommodate substituents at the 3-position of the beta-carbolines which have chain lengths less than or equal to C5.	Carbolines	165-180	H1.5 linker histone, cluster member	Homo sapiens	15-24
1530666-0	1992	Inhibition of histamine-N-methyltransferase (HNMT) by fragments of 9-amino-1,2,3,4-tetrahydroacridine (tacrine) and by beta-carbolines.	Carbolines	119-134	histamine N-methyltransferase	Rattus norvegicus	14-43
1530666-0	1992	Inhibition of histamine-N-methyltransferase (HNMT) by fragments of 9-amino-1,2,3,4-tetrahydroacridine (tacrine) and by beta-carbolines.	Carbolines	119-134	histamine N-methyltransferase	Rattus norvegicus	45-49
1652145-1	1991	Previous research has demonstrated that low doses of anxiogenic central benzodiazepine receptor (CBR) ligands, the beta-carbolines, improve performance in various learning and memory tests in animals if administered prior to training.	Carbolines	115-130	cannabinoid receptor 1	Rattus norvegicus	64-95
1652145-1	1991	Previous research has demonstrated that low doses of anxiogenic central benzodiazepine receptor (CBR) ligands, the beta-carbolines, improve performance in various learning and memory tests in animals if administered prior to training.	Carbolines	115-130	cannabinoid receptor 1	Rattus norvegicus	97-100
2137718-4	1990	The partially competitive nature of inhibition by one of the more effective pairs, 2-methyl-harmine and harmine, was consistent with uptake of the beta-carbolines by the synaptosomal dopamine uptake system, as was the fact that the accumulation of 2-[14C]methyl-harmine was significantly reduced by low Na+ media and by nomifensine, a potent inhibitor of the dopamine transporter.	Carbolines	147-162	solute carrier family 6 member 3	Homo sapiens	359-379
35312174-0	2022	A green synthesis of Carbene-metal-amido (CMAs) Complexes and Carboline -derived CMAs with potent in vitro and ex vivo anti cancer activity.	Carbolines	62-71	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	81-85
34560263-0	2021	Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype.	Carbolines	72-81	delta/notch-like EGF repeat containing	Mus musculus	15-18
2159126-2	1990	In rat brain DBI coexists with at least three different processing products and the members of this peptide family have been shown to displace benzodiazepines and beta carbolines from recognition sites located on the allosteric modulatory centers of GABAA receptors.	Carbolines	163-178	diazepam binding inhibitor	Rattus norvegicus	13-16
35180487-0	2022	Facile synthesis of C1-substituted beta-carbolines as CDK4 inhibitors for the treatment of cancer.	Carbolines	35-50	cyclin dependent kinase 4	Homo sapiens	54-58
2450203-1	1988	Effects of benzodiazepines (BDZs) and beta carbolines (beta CCs) on sustained repetitive firing at high frequency (SRF) of action potentials of mouse spinal cord neurons in cell culture were examined using intracellular recording techniques.	Carbolines	38-53	serum response factor	Mus musculus	115-118
3882420-6	1985	This protease and the factor altering ER-DNA binding were eluted together from chromatography on DEAE-cellulose, AcA 44, and carboline-agarose and were sensitive to the same inhibitors.	Carbolines	125-134	estrogen receptor 1	Bos taurus	38-40
3807051-1	1986	Two beta-carbolines, methyl beta-carboline-3-carboxylate (beta-CCM) and ethyl beta-carboline-3-carboxylate (beta-CCE), caused the parallel shift of the dose-response curve for cholecystokinin (CCK) in isolated guinea-pig gallbladder muscle.	Carbolines	4-19	cholecystokinin	Cavia porcellus	193-196
3819722-1	1987	Diazepam binding inhibitor (DBI), a peptide located in CNS neurons, blocks the binding of benzodiazepines and beta-carbolines to the allosteric modulatory sites of gamma-aminobutyric acid (GABAA) receptors.	Carbolines	110-125	diazepam binding inhibitor	Rattus norvegicus	0-32
3088605-5	1986	The concentration of 5 different beta-carbolines in platelet rich plasma (PRP) was measured using an HPLC-fluorometric method.	Carbolines	33-48	proline rich protein 2-like 1	Rattus norvegicus	74-77
6864229-0	1983	In vitro studies on the effect of beta-carbolines on the activities of acetylcholinesterase and choline acetyltransferase and on the muscarinic receptor binding of the rat brain.	Carbolines	34-49	acetylcholinesterase	Rattus norvegicus	71-91
6431906-5	1984	Pseudomonad tryptophan 2,3-dioxygenase was inhibited by a different spectrum of beta-carbolines.	Carbolines	80-95	tryptophan 2,3-dioxygenase	Homo sapiens	12-38
6864229-0	1983	In vitro studies on the effect of beta-carbolines on the activities of acetylcholinesterase and choline acetyltransferase and on the muscarinic receptor binding of the rat brain.	Carbolines	34-49	choline O-acetyltransferase	Rattus norvegicus	96-121
6864229-1	1983	Acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7) activity and muscarinic receptor binding of homogenates from several brain structures were inhibited by beta-carbolines.	Carbolines	169-184	acetylcholinesterase	Rattus norvegicus	0-20
7130973-1	1982	The inhibitory action of a range of beta-carbolines on human and rat monoamine oxidase (MAO) A and B has been studied.	Carbolines	36-51	monoamine oxidase A	Rattus norvegicus	69-100
6142598-10	1983	Beta-carbolines such as PCC also discriminate receptor subtypes, yet they act as antagonists at the BZ receptor.	Carbolines	0-15	crystallin gamma D	Homo sapiens	24-27
7130973-4	1982	Of the carbolines which have been found endogenously, tetrahydro-beta-carboline, 6-methoxytetrahydro-beta-carboline and harmane are all sufficiently potent inhibitors of human MAO A, with I50 values of 5 X 10(-6), 10(-6), 5 X 10(-7) M respectively, for this property to be of possible physiological significance.	Carbolines	7-17	monoamine oxidase A	Homo sapiens	176-181
6121956-3	1981	Biochemical studies have revealed beta-carbolines" several actions, including inhibition of MAO-A, competitive inhibition of 5-HT uptake, general inhibition of Na+ dependent transports, binding to benzodiazepine and opiate receptors and probable action on dopamine receptors, which may all participate to a variable degree in the actions of different beta-carbolines.	Carbolines	34-49	monoamine oxidase A	Homo sapiens	92-97
6121956-10	1981	It has been suggested that some beta-carbolines act as the physiological ligands (agonists) of the benzodiazepine receptors, but the physiological beta-carbolines so far known seem to have other effects, such as the inhibition of MAO-A or 5-HT uptake in low concentrations.	Carbolines	32-47	monoamine oxidase A	Homo sapiens	230-235
6121956-10	1981	It has been suggested that some beta-carbolines act as the physiological ligands (agonists) of the benzodiazepine receptors, but the physiological beta-carbolines so far known seem to have other effects, such as the inhibition of MAO-A or 5-HT uptake in low concentrations.	Carbolines	147-162	monoamine oxidase A	Homo sapiens	230-235
5035798-0	1972	Naturally occurring and synthetic  -carbolines as cholinesterase inhibitors.	Carbolines	36-46	butyrylcholinesterase	Homo sapiens	50-64
6255316-0	1980	[Study of binding of spin probes of the carboline and benzocarboline series to bovine serum albumin].	Carbolines	40-49	albumin	Homo sapiens	86-100
32761352-1	2020	CYP2D6 metabolically inactivates several neurotoxins, including beta-carbolines, which are implicated in neurodegenerative diseases.	Carbolines	64-79	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	0-6
31787028-2	2020	Previously we isolated a dimeric beta-carboline-type alkaloid Picrasidine C from the root of Picrasma quassioides as subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonist.	Carbolines	33-47	peroxisome proliferator activated receptor alpha	Homo sapiens	185-194
32761352-2	2020	Variation in CYP2D6 within the brain may alter local inactivation of neurotoxic beta-carbolines, thereby influencing neurotoxicity.	Carbolines	80-95	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	13-19
32926882-3	2020	The primary goal of this study was to evaluate the abuse potential of the beta-carbolines harmane, norharmane, and harmine - MAO inhibitors that are found in cigarette smoke - in an intracranial self-simulation (ICSS) model in rats.	Carbolines	74-89	monoamine oxidase A	Rattus norvegicus	125-128
32410501-1	2021	Pictet-Spengler cyclization method has been adopted for the synthesis of three carboline derived compounds: two compounds with tetrahydro gama- and beta- having CF3 group and amino alkyl chain at delta and alpha position, respectively, and another with guanidine alkyl chain at alpha-position.Structure-activity relationship of the analogues with human serum albumin was studied by fluorescence and Fourier-transform infrared spectroscopic analysis followed by molecular docking.	Carbolines	79-88	albumin	Homo sapiens	353-366
32766642-2	2020	In this work, two dinuclear phosphorescent rhenium(i) tricarbonyl complexes (DRe1 and DRe2) containing carboline derivatives have been synthesized, characterized and explored as potential chemotherapeutic and photodynamic therapy agents.	Carbolines	103-112	kelch like family member 24	Homo sapiens	77-81
32766642-2	2020	In this work, two dinuclear phosphorescent rhenium(i) tricarbonyl complexes (DRe1 and DRe2) containing carboline derivatives have been synthesized, characterized and explored as potential chemotherapeutic and photodynamic therapy agents.	Carbolines	103-112	cytokine induced apoptosis inhibitor 1	Homo sapiens	86-90
29268246-7	2018	As determined by HPLC-DAD, beta-carbolines, methylene blue, kaempferol and clorgyline inhibited MAO-A and methylene blue, 5-nitroindazole, norharman and deprenyl inhibited MAO-B, and all of them inhibited the oxidation of TMB in the same extent.	Carbolines	27-42	monoamine oxidase A	Homo sapiens	96-101
29268246-7	2018	As determined by HPLC-DAD, beta-carbolines, methylene blue, kaempferol and clorgyline inhibited MAO-A and methylene blue, 5-nitroindazole, norharman and deprenyl inhibited MAO-B, and all of them inhibited the oxidation of TMB in the same extent.	Carbolines	27-42	monoamine oxidase B	Homo sapiens	172-177
27977936-4	2017	The goal of this study is to determine the interaction of beta-carbolines with human OCT1, 2, and 3 (SLC22A1-3).	Carbolines	58-73	solute carrier family 22 member 1	Homo sapiens	85-99
27977936-4	2017	The goal of this study is to determine the interaction of beta-carbolines with human OCT1, 2, and 3 (SLC22A1-3).	Carbolines	58-73	solute carrier family 22 member 1	Homo sapiens	101-108
27977936-9	2017	All tested beta-carbolines potently inhibited hOCT2 with IC50 values in the sub- or low micromolar range.	Carbolines	11-26	solute carrier family 22 member 2	Homo sapiens	46-51
27977936-15	2017	Our data support a significant role of hOCT1-3 in tissue uptake and disposition of beta-carbolines.	Carbolines	83-98	solute carrier family 22 member 1	Homo sapiens	39-44
27977936-16	2017	Importantly, the potent inhibition of hOCT2 by beta-carbolines also raises the concern of potential drug interactions between naturally occurring bioactive alkaloids and drugs eliminated by hOCT2.	Carbolines	47-62	solute carrier family 22 member 2	Homo sapiens	38-43
27977936-16	2017	Importantly, the potent inhibition of hOCT2 by beta-carbolines also raises the concern of potential drug interactions between naturally occurring bioactive alkaloids and drugs eliminated by hOCT2.	Carbolines	47-62	solute carrier family 22 member 2	Homo sapiens	190-195
30326662-5	2018	Moreover, the levels of cytochrome C in mitochondria, and the expressions of bcl-2 protein, decreased after treatment with beta-carbolines, which indicated that 6i and 6u could induce mitochondria-mediated apoptosis.	Carbolines	123-138	cytochrome c, somatic	Homo sapiens	24-36
30326662-5	2018	Moreover, the levels of cytochrome C in mitochondria, and the expressions of bcl-2 protein, decreased after treatment with beta-carbolines, which indicated that 6i and 6u could induce mitochondria-mediated apoptosis.	Carbolines	123-138	BCL2 apoptosis regulator	Homo sapiens	77-82
29367595-7	2018	Molecular docking studies showed that the compounds could combine with the active site of AChE by the pi-pi or cation-pi action between the carboline ring and the phenyl rings of the residues, and the beta-carboline moiety is embedded in a cavity surrounded by four aromatic residues of Trp86, Tyr337, Trp439 and Tyr449.	Carbolines	140-149	acetylcholinesterase (Cartwright blood group)	Homo sapiens	90-94