PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 27378557-4 2016 OBJECTIVES: The objective of this review is to evaluate the accuracy of two alternative imaging tests - the dimercaptosuccinic acid renal scan (DMSA) and renal-bladder ultrasound (RBUS) - in diagnosing VUR and high-grade VUR (Grade III-V VUR). Succimer 108-131 VUR Homo sapiens 202-205 27378557-13 2016 A total of 19 studies reported data on the test performance of DMSA in detecting VUR; the summary sensitivity and specificity estimates were 0.75 (95% CI 0.67 to 0.81) and 0.48 (95% CI 0.38 to 0.57), respectively. Succimer 63-67 VUR Homo sapiens 81-84 27378557-14 2016 A total of 10 studies reported data on the accuracy of DMSA in detecting high-grade VUR. Succimer 55-59 VUR Homo sapiens 84-87 27378557-17 2016 Although a child with a negative DMSA test has an < 1% probability of having high-grade VUR, performing a screening DMSA will result in a large number of children falsely labelled as being at risk for high-grade VUR. Succimer 119-123 VUR Homo sapiens 215-218 27378557-18 2016 Accordingly, the usefulness of the DMSA as a screening test for high-grade VUR should be questioned. Succimer 35-39 VUR Homo sapiens 75-78 27423751-0 2016 Usefulness of 99mTc Dimercaptosuccinic acid scans after the first episode of urinary tract infection in children admitted to the Lady Ridgeway Hospital for Children, Sri Lanka. Succimer 20-43 sorcin Homo sapiens 166-169 26883975-4 2016 KEY FINDINGS: Our results demonstrate that the nanoparticulate formulation of dimercaptosuccinic acid (DMSA) and chitosan coated As2O3 is capable of inducing morphological changes, DNA damage and caspase-dependent apoptosis along with the expression of cyclin-dependent kinase inhibitor p21 by upregulation of Bax and downregulation of Bcl-2 and Bcl-xL proteins. Succimer 78-101 cyclin dependent kinase inhibitor 1A Homo sapiens 287-290 26960798-6 2016 Among single findings, dilatation of the renal collecting system, wall thickening of the renal collecting system, and DMSA scans significantly predicted VUR (P= .038, .027, and .01, respectively). Succimer 118-122 VUR Homo sapiens 153-156 26960798-9 2016 CONCLUSIONS: The negative predictive values indicate that normal renal sonographic and DMSA findings can predict the absence of high-grade VUR. Succimer 87-91 VUR Homo sapiens 139-142 28027609-6 2016 Among single findings, dilatation of the renal collecting system, wall thickening of the renal collecting system, and DMSA scans significantly predicted VUR (P= .038, .027, and .01, respectively). Succimer 118-122 VUR Homo sapiens 153-156 28027609-9 2016 CONCLUSIONS: The negative predictive values indicate that normal renal sonographic and DMSA findings can predict the absence of high-grade VUR. Succimer 87-91 VUR Homo sapiens 139-142 26370584-12 2016 Abnormal DMSA results were strongly associated with VUR grade (17.8% for VUR grades I-III vs 60.5% for VUR grades IV and V, P < 0.001). Succimer 9-13 VUR Homo sapiens 52-55 26370584-12 2016 Abnormal DMSA results were strongly associated with VUR grade (17.8% for VUR grades I-III vs 60.5% for VUR grades IV and V, P < 0.001). Succimer 9-13 VUR Homo sapiens 73-76 26370584-12 2016 Abnormal DMSA results were strongly associated with VUR grade (17.8% for VUR grades I-III vs 60.5% for VUR grades IV and V, P < 0.001). Succimer 9-13 VUR Homo sapiens 73-76 26883975-4 2016 KEY FINDINGS: Our results demonstrate that the nanoparticulate formulation of dimercaptosuccinic acid (DMSA) and chitosan coated As2O3 is capable of inducing morphological changes, DNA damage and caspase-dependent apoptosis along with the expression of cyclin-dependent kinase inhibitor p21 by upregulation of Bax and downregulation of Bcl-2 and Bcl-xL proteins. Succimer 78-101 BCL2 associated X, apoptosis regulator Homo sapiens 310-313 26883975-4 2016 KEY FINDINGS: Our results demonstrate that the nanoparticulate formulation of dimercaptosuccinic acid (DMSA) and chitosan coated As2O3 is capable of inducing morphological changes, DNA damage and caspase-dependent apoptosis along with the expression of cyclin-dependent kinase inhibitor p21 by upregulation of Bax and downregulation of Bcl-2 and Bcl-xL proteins. Succimer 78-101 BCL2 apoptosis regulator Homo sapiens 336-341 26883975-4 2016 KEY FINDINGS: Our results demonstrate that the nanoparticulate formulation of dimercaptosuccinic acid (DMSA) and chitosan coated As2O3 is capable of inducing morphological changes, DNA damage and caspase-dependent apoptosis along with the expression of cyclin-dependent kinase inhibitor p21 by upregulation of Bax and downregulation of Bcl-2 and Bcl-xL proteins. Succimer 78-101 BCL2 like 1 Homo sapiens 346-352 26883975-4 2016 KEY FINDINGS: Our results demonstrate that the nanoparticulate formulation of dimercaptosuccinic acid (DMSA) and chitosan coated As2O3 is capable of inducing morphological changes, DNA damage and caspase-dependent apoptosis along with the expression of cyclin-dependent kinase inhibitor p21 by upregulation of Bax and downregulation of Bcl-2 and Bcl-xL proteins. Succimer 103-107 cyclin dependent kinase inhibitor 1A Homo sapiens 287-290 26883975-4 2016 KEY FINDINGS: Our results demonstrate that the nanoparticulate formulation of dimercaptosuccinic acid (DMSA) and chitosan coated As2O3 is capable of inducing morphological changes, DNA damage and caspase-dependent apoptosis along with the expression of cyclin-dependent kinase inhibitor p21 by upregulation of Bax and downregulation of Bcl-2 and Bcl-xL proteins. Succimer 103-107 BCL2 associated X, apoptosis regulator Homo sapiens 310-313 26883975-4 2016 KEY FINDINGS: Our results demonstrate that the nanoparticulate formulation of dimercaptosuccinic acid (DMSA) and chitosan coated As2O3 is capable of inducing morphological changes, DNA damage and caspase-dependent apoptosis along with the expression of cyclin-dependent kinase inhibitor p21 by upregulation of Bax and downregulation of Bcl-2 and Bcl-xL proteins. Succimer 103-107 BCL2 apoptosis regulator Homo sapiens 336-341 26883975-4 2016 KEY FINDINGS: Our results demonstrate that the nanoparticulate formulation of dimercaptosuccinic acid (DMSA) and chitosan coated As2O3 is capable of inducing morphological changes, DNA damage and caspase-dependent apoptosis along with the expression of cyclin-dependent kinase inhibitor p21 by upregulation of Bax and downregulation of Bcl-2 and Bcl-xL proteins. Succimer 103-107 BCL2 like 1 Homo sapiens 346-352 27833443-12 2016 The cutoff value for detection of inflammatory changes in the DMSA scan for IL-8 was 120 pg/mg creatinine (Cr) and 40 pg/mg Cr for TGF-beta1. Succimer 62-66 C-X-C motif chemokine ligand 8 Homo sapiens 76-80 26275163-2 2016 This report investigated the effectiveness of renal bladder ultrasound (RBUS) and late 6 month dimercaptosuccinic acid (DMSA) renal scan in the detection of high-grade vesicoureteral reflux (VUR) after first febrile UTI in infants aged <1 year. Succimer 95-118 VUR Homo sapiens 191-194 26275163-2 2016 This report investigated the effectiveness of renal bladder ultrasound (RBUS) and late 6 month dimercaptosuccinic acid (DMSA) renal scan in the detection of high-grade vesicoureteral reflux (VUR) after first febrile UTI in infants aged <1 year. Succimer 120-124 VUR Homo sapiens 191-194 26275163-10 2016 Although late 6 month DMSA scan had higher sensitivity in the detection of high-grade VUR, with the added benefit of detection of renal scars, the practical application of this method was limited due to its high cost, radiation exposure and the associated delay in decision making. Succimer 22-26 VUR Homo sapiens 86-89 27143114-4 2016 IC50 values of MIBI, DTPA, DMSA and MDP were 0.056, 0.172, 0.274 and 0.175 mM, of hG6PD, respectively. Succimer 27-31 glucose-6-phosphate dehydrogenase Homo sapiens 82-87 26112850-8 2015 A significant association (P=0.0054) was noted with a combined sensitivity and specificity of these investigations being 83 and 90 per cent, respectively of the MCU and DMSA scans for detecting VUR. Succimer 169-173 VUR Homo sapiens 194-197 26243712-0 2015 Mechanism of Dimercaptosuccinic Acid Coated Superparamagnetic Iron Oxide Nanoparticles with Human Serum Albumin. Succimer 13-36 albumin Homo sapiens 98-111 26243712-1 2015 To research the mechanism of dimercaptosuccinic acid coated-superparamagnetic iron oxide nanoparticles (SPION) with human serum albumin (HSA), the methods of spectroscopy, molecular modeling calculation, and calorimetry were used in this paper. Succimer 29-52 albumin Homo sapiens 122-135 26378955-7 2015 This study provides new insight into the molecular mechanism by which the DMSA-coated nanoparticles resulted in the transcriptional changes of many CRP-coding genes in cells. Succimer 74-78 C-reactive protein Homo sapiens 148-151 26299930-4 2015 The REMP DmsD strongly interacts with the twin-arginine motif of the DmsA signal sequence of dimethyl sulfoxide (DMSO) reductase. Succimer 69-73 solute carrier family 16 member 8 Homo sapiens 4-8 26186402-4 2015 Covalent binding of EPS to DMSA-stabilized nanoparticles (MNP-DMSA) resulted in a hybrid magnetic-biopolymeric nanosystem (MNP-DMSA-EPS) with a hydrodynamic size of 170 nm, a negative surface charge under physiological conditions and transverse to longitudinal relaxivity ratio, r2/r1, of 148. Succimer 62-66 CD1e molecule Homo sapiens 279-292 26186402-4 2015 Covalent binding of EPS to DMSA-stabilized nanoparticles (MNP-DMSA) resulted in a hybrid magnetic-biopolymeric nanosystem (MNP-DMSA-EPS) with a hydrodynamic size of 170 nm, a negative surface charge under physiological conditions and transverse to longitudinal relaxivity ratio, r2/r1, of 148. Succimer 27-31 CD1e molecule Homo sapiens 279-292 26186402-4 2015 Covalent binding of EPS to DMSA-stabilized nanoparticles (MNP-DMSA) resulted in a hybrid magnetic-biopolymeric nanosystem (MNP-DMSA-EPS) with a hydrodynamic size of 170 nm, a negative surface charge under physiological conditions and transverse to longitudinal relaxivity ratio, r2/r1, of 148. Succimer 62-66 CD1e molecule Homo sapiens 279-292 26379425-1 2015 The objective of this study was to investigate the anticancer efficacy of dimercaptosuccinic acid-modified iron oxide magnetic nanoparticles coloaded with anti-CD22 antibodies and doxorubicin (anti-CD22-MNPs-DOX) on non-Hodgkin"s lymphoma cells. Succimer 74-97 CD22 molecule Homo sapiens 160-164 26379425-1 2015 The objective of this study was to investigate the anticancer efficacy of dimercaptosuccinic acid-modified iron oxide magnetic nanoparticles coloaded with anti-CD22 antibodies and doxorubicin (anti-CD22-MNPs-DOX) on non-Hodgkin"s lymphoma cells. Succimer 74-97 CD22 molecule Homo sapiens 198-202 26716196-4 2015 Subsequently, the anti-amyloid Abeta immunomagnetic nanoparticles (IMNPs) were prepared by grafting anti-amyloid antibodies on the surface of the DMSA-coated magnetic nanoparticles (MNPs). Succimer 146-150 amyloid beta precursor protein Homo sapiens 31-36 25522732-1 2015 In recent DNA microarray studies, we found that the transcription of the Id3 gene was significantly down-regulated in five cell lines (RAW264.7, Hepa1-6, THP-1, HepG2, and HL7702) treated with two doses (50 and 100 mug/mL) of a DMSA-coated magnetite nanoparticle. Succimer 228-232 inhibitor of DNA binding 3, HLH protein Homo sapiens 73-76 25522883-6 2015 Mapping the cross-linked sites on DmsD shows that the GroEL binding site is in close proximity to the previously characterized DmsA leader binding site. Succimer 127-131 GroEL Escherichia coli 54-59 25030771-10 2014 CONCLUSIONS: Based on our results, we suggest that DRNC may reveal VUR despite a normal VCUG in children with hydronephrosis, abnormal acute DMSA, and/or recurrent febrile UTI. Succimer 141-145 VUR Homo sapiens 67-70 25595381-0 2015 Effects of an 11-nm DMSA-coated iron nanoparticle on the gene expression profile of two human cell lines, THP-1 and HepG2. Succimer 20-24 GLI family zinc finger 2 Homo sapiens 106-111 25595381-4 2015 RESULTS: This study investigated the effects of an 11-nm dimercaptosuccinic acid-coated magnetite nanoparticle on the gene expression profiles of two human cell lines, THP-1 and HepG2. Succimer 57-80 GLI family zinc finger 2 Homo sapiens 168-173 25884412-3 2015 However, peptides prepared from Mf conjugated with alginate oligosaccharide (AO; 19 mug/mg protein) (dMSA) through the Maillard reaction in the presence of sorbitol significantly reduced the secretion of the pro-inflammatory mediators nitric oxide, tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, as well as mRNA expression of TNF-alpha, IL-6, inducible nitric oxide synthase and cyclooxygenase-2. Succimer 101-105 tumor necrosis factor Mus musculus 249-282 25884412-3 2015 However, peptides prepared from Mf conjugated with alginate oligosaccharide (AO; 19 mug/mg protein) (dMSA) through the Maillard reaction in the presence of sorbitol significantly reduced the secretion of the pro-inflammatory mediators nitric oxide, tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, as well as mRNA expression of TNF-alpha, IL-6, inducible nitric oxide synthase and cyclooxygenase-2. Succimer 101-105 interleukin 6 Mus musculus 287-305 25884412-3 2015 However, peptides prepared from Mf conjugated with alginate oligosaccharide (AO; 19 mug/mg protein) (dMSA) through the Maillard reaction in the presence of sorbitol significantly reduced the secretion of the pro-inflammatory mediators nitric oxide, tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, as well as mRNA expression of TNF-alpha, IL-6, inducible nitric oxide synthase and cyclooxygenase-2. Succimer 101-105 tumor necrosis factor Mus musculus 337-346 25884412-3 2015 However, peptides prepared from Mf conjugated with alginate oligosaccharide (AO; 19 mug/mg protein) (dMSA) through the Maillard reaction in the presence of sorbitol significantly reduced the secretion of the pro-inflammatory mediators nitric oxide, tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, as well as mRNA expression of TNF-alpha, IL-6, inducible nitric oxide synthase and cyclooxygenase-2. Succimer 101-105 interleukin 6 Mus musculus 348-352 25884412-3 2015 However, peptides prepared from Mf conjugated with alginate oligosaccharide (AO; 19 mug/mg protein) (dMSA) through the Maillard reaction in the presence of sorbitol significantly reduced the secretion of the pro-inflammatory mediators nitric oxide, tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, as well as mRNA expression of TNF-alpha, IL-6, inducible nitric oxide synthase and cyclooxygenase-2. Succimer 101-105 prostaglandin-endoperoxide synthase 2 Mus musculus 390-406 25881436-1 2014 2,3-Dimercaptosuccinic acid (DMSA) and its complex Nickel(II) 2,3-Dimercaptosuccinate (DMSA-Ni(II)) were assembled on the electrochemically activated Au electrode and the modified films were investigated by ex-situ SERS, SEM and electro-reduction. Succimer 0-27 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 215-219 25881436-1 2014 2,3-Dimercaptosuccinic acid (DMSA) and its complex Nickel(II) 2,3-Dimercaptosuccinate (DMSA-Ni(II)) were assembled on the electrochemically activated Au electrode and the modified films were investigated by ex-situ SERS, SEM and electro-reduction. Succimer 29-33 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 215-219 25881436-3 2014 Then, the SERS spectra showed that DMSA was absorbed on the surface of activated Au and the coordinate bond of DMSA-Ni(II) was existed as S-Ni-O. Succimer 35-39 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 10-14 25239520-5 2014 Both DMS and W123 were efficiently capable of suppressing FTY720-ameliorating effects in AD animals, either on memory deficit or on COX-II and TNF-alpha expression. Succimer 5-8 tumor necrosis factor Homo sapiens 143-152 24953543-13 2014 Contralateral GI VUR with normal DMSA isotope renal scans was resolved in 71% of RRUs. Succimer 33-37 VUR Homo sapiens 17-20 26568888-6 2015 Scarring on preoperative DMSA and dilating VUR ( III and IV) were significantly associated with recurrent VUR. Succimer 25-29 VUR Homo sapiens 107-110 25599732-1 2015 INTRODUCTION: Leukocyte count, erythrocyte sediment rate and C-reactive protein are available laboratory markers which may be helpful in prediction of technetium Tc 99m dimercaptosuccinic acid (DMSA) renal scintigraphy results. Succimer 194-198 C-reactive protein Homo sapiens 61-79 25476098-7 2014 High-grade VUR was present in 99 of 346 patients (28.9%) with abnormal DMSA scans, but present in only 16 of 233 patients (6.9%) with normal DMSA scans (p < 0.001). Succimer 71-75 VUR Homo sapiens 11-14 25476098-7 2014 High-grade VUR was present in 99 of 346 patients (28.9%) with abnormal DMSA scans, but present in only 16 of 233 patients (6.9%) with normal DMSA scans (p < 0.001). Succimer 141-145 VUR Homo sapiens 11-14 25476098-8 2014 Regarding the prediction of high-grade VUR, the sensitivity and negative predictive value (NPV) for the DMSA scans were 86.1% and 93.1%, respectively. Succimer 104-108 VUR Homo sapiens 39-42 25476098-10 2014 High-grade VUR was present in 12 of 36 patients (33.3%) with abnormal DMSA scans, whereas none of the 38 patients with normal DMSA scans had high-grade VUR (p < 0.001). Succimer 70-74 VUR Homo sapiens 11-14 24367995-0 2014 Structural characterization of Cd2+ complexes in solution with DMSA and DMPS. Succimer 63-67 CD2 molecule Homo sapiens 31-34 25378818-3 2014 Voiding cystourethrography (VCUG) and dimercaptosuccinic acid (DMSA) scan are the other main radiologic studies used to detect VUR. Succimer 38-61 VUR Homo sapiens 127-130 25378818-3 2014 Voiding cystourethrography (VCUG) and dimercaptosuccinic acid (DMSA) scan are the other main radiologic studies used to detect VUR. Succimer 63-67 VUR Homo sapiens 127-130 25378818-6 2014 We evaluated the sensitivity, specificity, and negative predictive values of RUS and DMSA for diagnosing VUR. Succimer 85-89 VUR Homo sapiens 105-108 24679246-1 2014 OBJECTIVE: The aim of this study was to evaluate the clinical outcome after endoscopic therapy by injection of bulking agent in the treatment of occult vesicoureteral reflux (VUR) [no VUR on standard voiding cystourethrography (VCUG), but positive (99m)Tc-2,3-dimercaptosuccinic acid (DMSA) scan] in females who have recurrent febrile urinary tract infections (UTIs). Succimer 285-289 VUR Homo sapiens 175-178 25175037-0 2014 Emission tunable, cyto/hemocompatible, near-IR-emitting Ag2S quantum dots by aqueous decomposition of DMSA. Succimer 102-106 angiotensin II receptor type 1 Homo sapiens 56-60 25175037-1 2014 Size tunable aqueous Ag2S quantum dots emitting in the near-infrared region were synthesized through decomposition of meso-2,3-dimercaptosuccinic acid (DMSA) in water. Succimer 118-150 angiotensin II receptor type 1 Homo sapiens 21-25 25175037-1 2014 Size tunable aqueous Ag2S quantum dots emitting in the near-infrared region were synthesized through decomposition of meso-2,3-dimercaptosuccinic acid (DMSA) in water. Succimer 152-156 angiotensin II receptor type 1 Homo sapiens 21-25 24731390-9 2014 DMSA showed photopenic areas in the contralateral kidneys in 10% of patients; all of them had hydronephrosis and were confirmed to have vesicoureteral reflux (VUR). Succimer 0-4 VUR Homo sapiens 159-162 24679886-9 2014 Cox regression analysis revealed that a normal initial dimercapto-succinic acid scan, initial reflux grade less than 5 and absent breakthrough febrile urinary tract infections were predictive of reflux resolution/improvement (p <0.05). Succimer 55-79 cytochrome c oxidase subunit 8A Homo sapiens 0-3 24311900-14 2013 DMSA scans were useful in predicting higher grades of VUR in children with primary reflux. Succimer 0-4 VUR Homo sapiens 54-57 24315308-1 2014 OBJECTIVE: To evaluate the role of renal ultrasonography (USG) in predicting vesicoureteral reflux (VUR) in children with mild renal scarring determined by dimercaptosuccinic acid scintigraphy performed after attack of urinary tract infections (UTI). Succimer 156-179 VUR Homo sapiens 100-103 23465483-7 2013 CONCLUSIONS: Focal DMSA defects were present in 15.5% of 565 consecutive children referred for febrile UTI and/or VUR; 4% had presumed congenital reflux nephropathy without cortical defect. Succimer 19-23 VUR Homo sapiens 114-117 23354031-1 2013 OBJECTIVE: This study aimed to examine the ability of acute (99m)Tc DMSA scan for predicting dilating (grades III-V) vesicoureteral reflux (VUR) after a first febrile urinary tract infection in children aged 2 years or younger. Succimer 68-72 VUR Homo sapiens 140-143 23481452-1 2013 OBJECTIVE: The aim of this study is to compare two biologic parameters; C-reactive protein (CRP) and procalcitonin (PCT) in the detection of acute renal lesions assessed by DMSA scintigraphy in the urinary tract infection in child. Succimer 173-177 C-reactive protein Homo sapiens 72-90 23481452-1 2013 OBJECTIVE: The aim of this study is to compare two biologic parameters; C-reactive protein (CRP) and procalcitonin (PCT) in the detection of acute renal lesions assessed by DMSA scintigraphy in the urinary tract infection in child. Succimer 173-177 C-reactive protein Homo sapiens 92-95 23354031-9 2013 CONCLUSIONS: Our results reveal the usefulness of acute (99m)Tc DMSA scan for predicting dilating VUR in children with a first febrile urinary tract infection. Succimer 64-68 VUR Homo sapiens 98-101 23354031-7 2013 The sensitivity and negative predictive value in predicting dilating VUR were 95.8% and 97.9%, respectively, for (99m)Tc DMSA and 97.9% and 98.6%, respectively, for combined US and (99m)Tc DMSA, whereas the positive and negative likelihood ratios were 1.90 and 0.08, respectively, for (99m)Tc DMSA and 1.57 and 0.06, respectively, for combined studies. Succimer 121-125 VUR Homo sapiens 69-72 23354031-7 2013 The sensitivity and negative predictive value in predicting dilating VUR were 95.8% and 97.9%, respectively, for (99m)Tc DMSA and 97.9% and 98.6%, respectively, for combined US and (99m)Tc DMSA, whereas the positive and negative likelihood ratios were 1.90 and 0.08, respectively, for (99m)Tc DMSA and 1.57 and 0.06, respectively, for combined studies. Succimer 189-193 VUR Homo sapiens 69-72 23354031-7 2013 The sensitivity and negative predictive value in predicting dilating VUR were 95.8% and 97.9%, respectively, for (99m)Tc DMSA and 97.9% and 98.6%, respectively, for combined US and (99m)Tc DMSA, whereas the positive and negative likelihood ratios were 1.90 and 0.08, respectively, for (99m)Tc DMSA and 1.57 and 0.06, respectively, for combined studies. Succimer 189-193 VUR Homo sapiens 69-72 23203209-11 2013 However, abnormal renal ultrasonography and VUR had significant correlations with abnormal DMSA renal scintigraphy at p values 0.022 and < 0.001 in patients and at p values 0.024 and < 0.001 in renal units, respectively. Succimer 91-95 VUR Homo sapiens 44-47 23203209-13 2013 However, severe VUR (Grade IV-V) had significant correlations with abnormal DMSA renal scintigraphy at p values < 0.001 and < 0.001, respectively. Succimer 76-80 VUR Homo sapiens 16-19 21440393-3 2012 The specific interactions between Glut1-overexpressing tumor cells (MDA-MB-231) and gamma-Fe(2)O(3)@DMSA-DG NPs were observed using Prussian blue staining and transmission electron microscope (TEM), and found that gamma-Fe(2)O(3)@DMSA-DG NPs were absorbed targetedly by the cells. Succimer 100-104 solute carrier family 2 member 1 Homo sapiens 34-39 22374404-10 2012 CONCLUSIONS: To screen high-grade VUR in young infants with febrile UTI, US and acute DMSA scan could be performed first. Succimer 86-90 VUR Homo sapiens 34-37 23056860-4 2012 This study was done to predict VUR by DMSA scan (technetium 99 m-labeled dimercaptosuccinic acid) and ultrasonography (US). Succimer 38-42 VUR Homo sapiens 31-34 23056860-4 2012 This study was done to predict VUR by DMSA scan (technetium 99 m-labeled dimercaptosuccinic acid) and ultrasonography (US). Succimer 73-96 VUR Homo sapiens 31-34 23056860-15 2012 So, more studies are needed to determine the usefulness of DMSA scan and US instead of VCUG for detection of VUR. Succimer 59-63 VUR Homo sapiens 109-112 23136633-6 2012 At the initial examination, VUR was more often associated with an abnormal DMSA scan result (83.3%) than with a normal DMSA scan result (16.7%, p=0.02). Succimer 75-79 VUR Homo sapiens 28-31 23136633-6 2012 At the initial examination, VUR was more often associated with an abnormal DMSA scan result (83.3%) than with a normal DMSA scan result (16.7%, p=0.02). Succimer 119-123 VUR Homo sapiens 28-31 23136633-7 2012 The frequency of VUR with an abnormal DMSA scan during acute UTI was significantly higher than the frequency of VUR with a normal DMSA scan (38.8% vs, 25.8%, respectively, p=0.004). Succimer 38-42 VUR Homo sapiens 17-20 23136633-7 2012 The frequency of VUR with an abnormal DMSA scan during acute UTI was significantly higher than the frequency of VUR with a normal DMSA scan (38.8% vs, 25.8%, respectively, p=0.004). Succimer 130-134 VUR Homo sapiens 17-20 23136633-8 2012 Also, high-grade VUR was associated with an abnormal DMSA scan result (32.5%) more often than with a normal DMSA scan result (0%, p=0.01). Succimer 53-57 VUR Homo sapiens 17-20 23136633-8 2012 Also, high-grade VUR was associated with an abnormal DMSA scan result (32.5%) more often than with a normal DMSA scan result (0%, p=0.01). Succimer 108-112 VUR Homo sapiens 17-20 23136633-9 2012 Children with an abnormal DMSA scan had a lower resolution rate of VUR (17.5%) than did children with a normal DMSA scan (75.0%) at the follow-up VCUG (p=0.02). Succimer 26-30 VUR Homo sapiens 67-70 23136633-10 2012 CONCLUSIONS: An abnormal result on a DMSA scan during febrile UTI is associated with high-grade and persistent VUR. Succimer 37-41 VUR Homo sapiens 111-114 23084719-7 2012 Positive DMSA findings significantly correlated with VUR (p<0.001) and higher C-reactive protein level (p<0.05). Succimer 9-13 C-reactive protein Homo sapiens 81-99 23084719-10 2012 Positive DMSA was well correlated with VUR and higher C-reactive protein level. Succimer 9-13 C-reactive protein Homo sapiens 54-72 22377253-13 2012 Measuring urine level of ET-1 can help us to avoid unnecessary DMSA studies if the patient"s uET-1 level is found to be under the determined cut-off point. Succimer 63-67 endothelin 1 Homo sapiens 25-29 21440393-3 2012 The specific interactions between Glut1-overexpressing tumor cells (MDA-MB-231) and gamma-Fe(2)O(3)@DMSA-DG NPs were observed using Prussian blue staining and transmission electron microscope (TEM), and found that gamma-Fe(2)O(3)@DMSA-DG NPs were absorbed targetedly by the cells. Succimer 230-234 solute carrier family 2 member 1 Homo sapiens 34-39 21440393-5 2012 It was found that the acquired MRI T2 signal intensity of MDA-MB-231 cells that were treated with the gamma-Fe(2)O(3)@DMSA-DG NPs decreased significantly, and it was inhibited by competition with antibody of Glut1. Succimer 118-122 solute carrier family 2 member 1 Homo sapiens 208-213 22912902-7 2012 Moreover, mutations of sod-2 and sod-3 genes, encoding Mn-SODs, showed more susceptible properties than wild-type when they were used for assessing the DMSA coated Fe(2)O(3)-NPs-induced toxicity, and the safety concentrations for DMSA coated Fe(2)O(3)-NPs should be defined as concentrations lower than 10 mug/L in sod-2 and sod-3 mutant nematodes. Succimer 230-234 Superoxide dismutase [Mn] 2, mitochondrial Caenorhabditis elegans 33-38 22089774-7 2011 Thus, our study shows that a normal DMSA scan can help in ruling out moderate to severe forms of VUR and that cystography remains an excellent and standard tool for the diagnosis of VUR. Succimer 36-40 VUR Homo sapiens 97-100 22912902-7 2012 Moreover, mutations of sod-2 and sod-3 genes, encoding Mn-SODs, showed more susceptible properties than wild-type when they were used for assessing the DMSA coated Fe(2)O(3)-NPs-induced toxicity, and the safety concentrations for DMSA coated Fe(2)O(3)-NPs should be defined as concentrations lower than 10 mug/L in sod-2 and sod-3 mutant nematodes. Succimer 152-156 Superoxide dismutase [Mn] 1, mitochondrial Caenorhabditis elegans 23-28 22912902-7 2012 Moreover, mutations of sod-2 and sod-3 genes, encoding Mn-SODs, showed more susceptible properties than wild-type when they were used for assessing the DMSA coated Fe(2)O(3)-NPs-induced toxicity, and the safety concentrations for DMSA coated Fe(2)O(3)-NPs should be defined as concentrations lower than 10 mug/L in sod-2 and sod-3 mutant nematodes. Succimer 152-156 Superoxide dismutase [Mn] 2, mitochondrial Caenorhabditis elegans 33-38 22912902-7 2012 Moreover, mutations of sod-2 and sod-3 genes, encoding Mn-SODs, showed more susceptible properties than wild-type when they were used for assessing the DMSA coated Fe(2)O(3)-NPs-induced toxicity, and the safety concentrations for DMSA coated Fe(2)O(3)-NPs should be defined as concentrations lower than 10 mug/L in sod-2 and sod-3 mutant nematodes. Succimer 230-234 Superoxide dismutase [Mn] 1, mitochondrial Caenorhabditis elegans 23-28 21277630-0 2011 Dimercaptosuccinic acid-coated magnetite nanoparticles for magnetically guided in vivo delivery of interferon gamma for cancer immunotherapy. Succimer 0-23 interferon gamma Mus musculus 99-115 21331646-11 2011 Conversely, increased concentrations of TGF-beta1 pointed out to renal damage as indicated by reduced DMSA uptake. Succimer 102-106 transforming growth factor beta 1 Homo sapiens 40-49 20143189-1 2011 BACKGROUND: We evaluated the variation of calcitonin gene related peptide (CGRP) expression in patients with mixed invasive with extensive in situ ductal carcinomas (IDC + DCIS) and pure IDC, in relation to mammographic breast density (%BD), proliferation-seeking radiotracer (99m)Tc(V) dimercaptosuccinic acid (DMSA) uptake (scintimammographic-SMM), proliferation index Ki-67, and estrogen receptor (ER) status. Succimer 287-310 calcitonin related polypeptide alpha Homo sapiens 75-79 20143189-1 2011 BACKGROUND: We evaluated the variation of calcitonin gene related peptide (CGRP) expression in patients with mixed invasive with extensive in situ ductal carcinomas (IDC + DCIS) and pure IDC, in relation to mammographic breast density (%BD), proliferation-seeking radiotracer (99m)Tc(V) dimercaptosuccinic acid (DMSA) uptake (scintimammographic-SMM), proliferation index Ki-67, and estrogen receptor (ER) status. Succimer 312-316 calcitonin related polypeptide alpha Homo sapiens 75-79 21511275-6 2011 In the subgroup of children with a positive results on dimercaptosuccinic acid scan, PCT >=0.5 ng/mL was also associated with high-grade VUR (adjusted OR, 4.8; 95% CI, 1.3 to 17.6). Succimer 55-78 VUR Homo sapiens 140-143 21277630-2 2011 In mouse models of cancer, we tested uniform dimercaptosuccinic acid (DMSA)-coated monodisperse magnetic nanoparticles as a delivery system for the anti-tumorigenic cytokine IFN-gamma. Succimer 45-68 interferon gamma Mus musculus 174-183 21277630-2 2011 In mouse models of cancer, we tested uniform dimercaptosuccinic acid (DMSA)-coated monodisperse magnetic nanoparticles as a delivery system for the anti-tumorigenic cytokine IFN-gamma. Succimer 70-74 interferon gamma Mus musculus 174-183 21277630-3 2011 IFN-gamma-adsorbed DMSA-coated magnetic nanoparticles were targeted to the tumor site by application of an external magnetic field. Succimer 19-23 interferon gamma Mus musculus 0-9 21277630-7 2011 Our findings indicate that IFN-gamma-adsorbed DMSA-coated magnetite nanoparticles can be used as an efficient in vivo drug delivery system for tumor immunotherapy. Succimer 46-50 interferon gamma Mus musculus 27-36 20810785-7 2011 The antagonistic effects on TrxR inhibition were extended to endogenous antioxidants, such as GSH, and clinically used exogenous chelating agents BAL, DMPS, DMSA, and alpha-lipoic acid. Succimer 157-161 peroxiredoxin 5 Homo sapiens 28-32 21112928-0 2011 P53 and Bcl2 apoptosis proteins in meso-2,3-dimercaptosuccinic acid treated lead-intoxicated rabbits. Succimer 35-67 BCL-2 Oryctolagus cuniculus 8-12 20935452-5 2011 The critical relevance of the beta2 integrin-dependent pathway in leukocyte transmigration elicited by MNPs-DMSA was demonstrated by use of knockout mice. Succimer 108-112 hemoglobin, beta adult minor chain Mus musculus 30-35 20935452-6 2011 Our work characterizes mechanisms of the pro-inflammatory effects of MNPs-DMSA in the lung, and identifies beta2 integrin-targeted interventions as promising strategies to reduce pulmonary side effects of MNPs-DMSA during biomedical applications. Succimer 210-214 hemoglobin, beta adult minor chain Mus musculus 107-112 19593590-3 2009 We evaluated the sensitivity, specificity, and positive and negative predictive values of US and DMSA scans in diagnosing VUR. Succimer 97-101 VUR Homo sapiens 122-125 20679300-1 2010 OBJECTIVES: The objective of this study was to assess the ability of acute dimercaptosuccinic acid (DMSA) scintigraphy for revealing vesicoureteral reflux (VUR) in young children after a first febrile urinary tract infection (UTI). Succimer 75-98 VUR Homo sapiens 156-159 20679300-1 2010 OBJECTIVES: The objective of this study was to assess the ability of acute dimercaptosuccinic acid (DMSA) scintigraphy for revealing vesicoureteral reflux (VUR) in young children after a first febrile urinary tract infection (UTI). Succimer 100-104 VUR Homo sapiens 156-159 20679300-5 2010 Abnormal DMSA scan results were associated with an odds ratio of 4.36 for dilating and 5.50 for severe VUR. Succimer 9-13 VUR Homo sapiens 103-106 20679300-7 2010 Children with abnormal DMSA scan results combined with abnormal ultrasonography had an odds ratio of 3.60 for dilating and 6.32 for severe VUR. Succimer 23-27 VUR Homo sapiens 139-142 19620025-1 2010 OBJECTIVE: Current imaging recommendations for investigating any infantile febrile urinary tract infection (UTI) are ultrasound scan (US), micturating cystourethrogram (MCUG) and dimercaptosuccinic acid (DMSA) scan. Succimer 179-202 alpha-1-microglobulin/bikunin precursor Homo sapiens 108-111 19620025-1 2010 OBJECTIVE: Current imaging recommendations for investigating any infantile febrile urinary tract infection (UTI) are ultrasound scan (US), micturating cystourethrogram (MCUG) and dimercaptosuccinic acid (DMSA) scan. Succimer 204-208 alpha-1-microglobulin/bikunin precursor Homo sapiens 108-111 19620025-11 2010 CONCLUSION: We recommend US and DMSA in all infantile febrile UTI cases. Succimer 32-36 alpha-1-microglobulin/bikunin precursor Homo sapiens 62-65 19822361-0 2010 The effect of DMSA-functionalized magnetic nanoparticles on transendothelial migration of monocytes in the murine lung via a beta2 integrin-dependent pathway. Succimer 14-18 histocompatibility 2, O region beta locus Mus musculus 123-130 19579036-9 2009 These results strongly suggest that DMSA is filtered in the glomeruli and subsequently undergoes megalin- and cubilin-mediated endocytosis in the proximal tubules. Succimer 36-40 LDL receptor related protein 2 Homo sapiens 97-104 19579036-9 2009 These results strongly suggest that DMSA is filtered in the glomeruli and subsequently undergoes megalin- and cubilin-mediated endocytosis in the proximal tubules. Succimer 36-40 cubilin Homo sapiens 110-117 20580805-8 2010 The co-treatment of SGE and DMSA had a synergism in increasing brain, liver and kidney superoxide dismutase (SOD), catalase (CAT) activities and GSH level, and decreasing oxidized glutathione (GSSG) and thiobarbituric acid reactive substances (TBARS) levels. Succimer 28-32 catalase Rattus norvegicus 115-123 20580805-8 2010 The co-treatment of SGE and DMSA had a synergism in increasing brain, liver and kidney superoxide dismutase (SOD), catalase (CAT) activities and GSH level, and decreasing oxidized glutathione (GSSG) and thiobarbituric acid reactive substances (TBARS) levels. Succimer 28-32 catalase Rattus norvegicus 125-128 19593590-6 2009 Detection rate of VUR by DMSA scan was 37.5% and 88.4% in the low and high grade groups, respectively. Succimer 25-29 VUR Homo sapiens 18-21 19593590-7 2009 Combining US and DMSA scan, we found that the detection rate of high grade VUR was 95.3% and that of low grade was 62.5%. Succimer 17-21 VUR Homo sapiens 75-78 19661052-8 2009 The sensitivity and specificity of abnormal early DMSA scintigraphic results to predict grade > or =III VUR were 29% (95% confidence interval: 11%-55%) and 82% (95% confidence interval: 74%-88%), respectively. Succimer 50-54 VUR Homo sapiens 107-110 19352723-1 2009 The aim of this study was to test our hypothesis that the urinary excretion of C-reactive protein (CRP), alpha 1-microglobulin (A1M), retinol-binding protein (RBP) and Clara cell protein (CC16) is increased in children with urinary tract infection (UTI) and relates to renal damage as measured by acute dimercaptosuccinic acid (DMSA) scintigraphy. Succimer 303-326 C-reactive protein Homo sapiens 79-97 19352723-1 2009 The aim of this study was to test our hypothesis that the urinary excretion of C-reactive protein (CRP), alpha 1-microglobulin (A1M), retinol-binding protein (RBP) and Clara cell protein (CC16) is increased in children with urinary tract infection (UTI) and relates to renal damage as measured by acute dimercaptosuccinic acid (DMSA) scintigraphy. Succimer 328-332 C-reactive protein Homo sapiens 79-97 19352723-5 2009 There was a significant association between DMSA class and the excretion of urinary RBP (u-RBP) and u-CC16. Succimer 44-48 retinol binding protein 4 Homo sapiens 84-87 19352723-5 2009 There was a significant association between DMSA class and the excretion of urinary RBP (u-RBP) and u-CC16. Succimer 44-48 retinol binding protein 4 Homo sapiens 91-94 19352723-5 2009 There was a significant association between DMSA class and the excretion of urinary RBP (u-RBP) and u-CC16. Succimer 44-48 secretoglobin family 1A member 1 Homo sapiens 102-106 19352723-7 2009 In conclusion, the urinary excretion of the low-molecular-weight proteins RBP and CC16 showed a strong association with uptake defects on renal DMSA scans. Succimer 144-148 retinol binding protein 4 Homo sapiens 74-77 19352723-7 2009 In conclusion, the urinary excretion of the low-molecular-weight proteins RBP and CC16 showed a strong association with uptake defects on renal DMSA scans. Succimer 144-148 secretoglobin family 1A member 1 Homo sapiens 82-86 19452940-6 2009 In contrast, macrophage antigen-1 and leukocyte function associated antigen-1 were found in capillary only in animals treated with magnetic fluid surface-coated with meso-2,3-dimercaptosuccinic acid administration. Succimer 166-198 macrophage antigen 1 Mus musculus 13-77 19478237-10 2009 Various thiols that differentially supported AsV reduction when present during PNP-catalyzed arsenolysis (DTT approximately dimercaptopropane-1-sulfonic acid > mercaptoethanol > DMSA > GSH) similarly supported AsV reduction when added only after a transient PNP-catalyzed arsenolysis, which preformed ribose-1-arsenate. Succimer 184-188 purine nucleoside phosphorylase Homo sapiens 79-82 19452940-8 2009 Our findings demonstrated that magnetic fluid surface-coated with meso-2,3-dimercaptosuccinic acid administration exhibits modulation effects on expression patterns of E-selectin, macrophage antigen-1, and leukocyte function associated antigen-1 in the lung"s vascular compartments. Succimer 66-98 selectin, endothelial cell Mus musculus 168-178 18800229-9 2009 Of those patients with pyelonephritis, based on the DMSA scan at the time of infection, scarring on follow-up DMSA scan 9-12 months later occurred in patients with the highest urinary MIF/Cr ratios. Succimer 110-114 macrophage migration inhibitory factor Homo sapiens 184-187 19063911-0 2009 MRP2 involvement in renal proximal tubular elimination of methylmercury mediated by DMPS or DMSA. Succimer 92-96 ATP binding cassette subfamily C member 2 Rattus norvegicus 0-4 19063911-3 2009 In the present study, we extended our previous studies by testing the hypothesis that MRP2 mediates the secretion of DMPS or DMSA S-conjugates of CH(3)Hg(+). Succimer 125-129 ATP binding cassette subfamily C member 2 Rattus norvegicus 86-90 19063911-11 2009 Our findings in inside-out membrane vesicles prepared from hMRP2-transfected Sf9 cells show that uptake of DMPS and DMSA S-conjugates of CH(3)Hg(+) was greater in the vesicles containing hMRP2 than in control vesicles. Succimer 116-120 ATP binding cassette subfamily C member 2 Homo sapiens 59-64 19063911-12 2009 Overall, these dispositional findings indicate that MRP2 does play a role in DMPS- and DMSA-mediated elimination of mercury from the kidney. Succimer 87-91 ATP binding cassette subfamily C member 2 Rattus norvegicus 52-56 18511429-12 2008 Overall, these data support our hypothesis that Mrp2 is involved in the DMPS and DMSA-mediated extraction of the body burden of Hg2+. Succimer 81-85 ATP binding cassette subfamily C member 2 Rattus norvegicus 48-52 19260317-13 2008 Middle and high-dose TFCM was more effective than DMSA in increasing the activity of GSH, GSH-Px, SOD, CAT and decreasing the concentration of MDA in mice brain. Succimer 50-54 catalase Mus musculus 103-106 19260317-14 2008 In addition, high-dose TFCM was more effective than DMSA in increasing the activity of GSH-Px, CAT and decreasing the concentration of MDA in mice liver and kidney. Succimer 52-56 catalase Mus musculus 95-98 19198310-0 2008 Evaluation of the binding properties of maghemite nanoparticle surface-coated with meso-2-3-dimercaptosuccinic acid to serum albumin. Succimer 83-115 albumin Mus musculus 119-132 19198310-1 2008 In this study the interaction between magnetic nanoparticles (MNPs) surface-coated with meso-2,3-dimercaptosuccinic acid (DMSA) with both bovine serum albumin (BSA) and human serum albumin (HSA) was investigated. Succimer 88-120 albumin Mus musculus 145-158 19198310-1 2008 In this study the interaction between magnetic nanoparticles (MNPs) surface-coated with meso-2,3-dimercaptosuccinic acid (DMSA) with both bovine serum albumin (BSA) and human serum albumin (HSA) was investigated. Succimer 88-120 albumin Mus musculus 175-188 19198310-1 2008 In this study the interaction between magnetic nanoparticles (MNPs) surface-coated with meso-2,3-dimercaptosuccinic acid (DMSA) with both bovine serum albumin (BSA) and human serum albumin (HSA) was investigated. Succimer 88-120 CD24a antigen Mus musculus 190-193 19198310-1 2008 In this study the interaction between magnetic nanoparticles (MNPs) surface-coated with meso-2,3-dimercaptosuccinic acid (DMSA) with both bovine serum albumin (BSA) and human serum albumin (HSA) was investigated. Succimer 122-126 albumin Mus musculus 145-158 19198310-1 2008 In this study the interaction between magnetic nanoparticles (MNPs) surface-coated with meso-2,3-dimercaptosuccinic acid (DMSA) with both bovine serum albumin (BSA) and human serum albumin (HSA) was investigated. Succimer 122-126 albumin Mus musculus 175-188 19198310-1 2008 In this study the interaction between magnetic nanoparticles (MNPs) surface-coated with meso-2,3-dimercaptosuccinic acid (DMSA) with both bovine serum albumin (BSA) and human serum albumin (HSA) was investigated. Succimer 122-126 CD24a antigen Mus musculus 190-193 19198310-2 2008 The binding of the MNP-DMSA was probed by the fluorescence quenching of the BSA and HSA tryptophan residue. Succimer 23-27 modifier of Niemann Pick type C1 Mus musculus 19-22 19198310-2 2008 The binding of the MNP-DMSA was probed by the fluorescence quenching of the BSA and HSA tryptophan residue. Succimer 23-27 CD24a antigen Mus musculus 84-87 19198310-4 2008 The binding constants (Kb) and the complex stoichiometries (n) indicate that MNP-DMSA/BSA and MNP-DMSA/HSA complexes have low association profiles. Succimer 81-85 modifier of Niemann Pick type C1 Mus musculus 77-80 19198310-4 2008 The binding constants (Kb) and the complex stoichiometries (n) indicate that MNP-DMSA/BSA and MNP-DMSA/HSA complexes have low association profiles. Succimer 81-85 CD24a antigen Mus musculus 94-106 19198310-5 2008 After five minutes following intravenous injection of MNP-DMSA into mice"s blood stream we found the lung firstly target by the MNP-DMSA, followed by the liver in a latter stage. Succimer 58-62 modifier of Niemann Pick type C1 Mus musculus 54-57 19198310-5 2008 After five minutes following intravenous injection of MNP-DMSA into mice"s blood stream we found the lung firstly target by the MNP-DMSA, followed by the liver in a latter stage. Succimer 58-62 modifier of Niemann Pick type C1 Mus musculus 128-131 19198310-5 2008 After five minutes following intravenous injection of MNP-DMSA into mice"s blood stream we found the lung firstly target by the MNP-DMSA, followed by the liver in a latter stage. Succimer 132-136 modifier of Niemann Pick type C1 Mus musculus 54-57 18511429-2 2008 The metal chelators, 2,3-dimercaptopropane-1-sulfonic acid (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA), have been used successfully to extract Hg2+ from these cells, presumably via the multidrug resistance protein (Mrp2). Succimer 70-102 ATP binding cassette subfamily C member 2 Rattus norvegicus 222-226 18511429-2 2008 The metal chelators, 2,3-dimercaptopropane-1-sulfonic acid (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA), have been used successfully to extract Hg2+ from these cells, presumably via the multidrug resistance protein (Mrp2). Succimer 104-108 ATP binding cassette subfamily C member 2 Rattus norvegicus 222-226 18511429-3 2008 In the current study, we tested the hypothesis that Mrp2 is involved in the DMPS- and DMSA-mediated extraction of Hg2+ following administration of Hg2+ as an S-conjugate of Cys or Hcy. Succimer 86-90 ATP binding cassette subfamily C member 2 Rattus norvegicus 52-56 18511429-11 2008 In vitro experiments provide direct evidence indicating that DMPS and DMSA-S-conjugates of Hg2+ are substrates for Mrp2. Succimer 70-76 ATP binding cassette subfamily C member 2 Rattus norvegicus 115-119 19198310-5 2008 After five minutes following intravenous injection of MNP-DMSA into mice"s blood stream we found the lung firstly target by the MNP-DMSA, followed by the liver in a latter stage. Succimer 132-136 modifier of Niemann Pick type C1 Mus musculus 128-131 19198310-7 2008 This indicates that biocompatible MNP-DMSA is a very promising material system to be used as a drug delivery system (DDS), primarily for lung cancer treatment. Succimer 38-42 modifier of Niemann Pick type C1 Mus musculus 34-37 18982468-13 2008 The presence of VUR on MCU increased the chance of renal damage on DMSA by about 15%, whereas negative MCU increased the chance of no-renal involvement by 9%. Succimer 67-71 VUR Homo sapiens 16-19 17287888-6 2008 DMSA supplemented alone could reduce lead levels in both soft tissues and bone and reverse lead-inhibited activities of blood ALAD in mild to moderately lead-intoxicated mice. Succimer 0-4 aminolevulinate, delta-, dehydratase Mus musculus 126-130 32907220-2 2008 For yeast cytochrome c, the attachment is covalent and site-specific via dithiol cross-linkage between cysteine 102 and dimercaptosuccinic acid, the nanoparticle ligand. Succimer 120-143 cytochrome c, somatic Equus caballus 10-22 17287888-7 2008 On the other hand, combined use of DMSA with calcium and ascorbic acid achieved better therapeutic efficacies in mobilizing lead in blood, liver and kidney, and reversing lead-inhibited activities of blood ALAD in moderately lead intoxicated mice than DMSA supplemented alone. Succimer 35-39 aminolevulinate, delta-, dehydratase Mus musculus 206-210 17250996-3 2007 Subsequentially, the anti-human cardiac troponin I (cTnI) immunomagnetic nanoparticles (IMNPs) were prepared by grafting anti-human cTnI antibodies on the surface of DMSA-coated MNPs using the linker of EDC (1-ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride). Succimer 166-170 troponin I3, cardiac type Homo sapiens 32-50 18769557-5 2008 The increasing evidence of the role of DMSA scans in managing children with VUR is highlighted. Succimer 39-43 VUR Homo sapiens 76-79 18035134-1 2007 OBJECTIVE: To test the hypothesis that infants with dilating vesicoureteral reflux (VUR) have abnormal acute dimercaptosuccinic acid (DMSA) scintigraphy results, as was suggested by an earlier retrospective study. Succimer 109-132 VUR Homo sapiens 84-87 18035134-1 2007 OBJECTIVE: To test the hypothesis that infants with dilating vesicoureteral reflux (VUR) have abnormal acute dimercaptosuccinic acid (DMSA) scintigraphy results, as was suggested by an earlier retrospective study. Succimer 134-138 VUR Homo sapiens 84-87 18035134-7 2007 CONCLUSION: DMSA scintigraphy results were abnormal in all 27 infants with dilating VUR except 1. Succimer 12-16 VUR Homo sapiens 84-87 18035134-9 2007 This supports our hypothesis that DMSA scintigraphy results are abnormal when there is dilating VUR. Succimer 34-38 VUR Homo sapiens 96-99 17998108-1 2007 UNLABELLED: Dimercaptosuccinic acid (DMSA) exists in meso and racemic (rac) forms. Succimer 12-35 Rac family small GTPase 2 Mus musculus 62-65 17998108-1 2007 UNLABELLED: Dimercaptosuccinic acid (DMSA) exists in meso and racemic (rac) forms. Succimer 37-41 Rac family small GTPase 2 Mus musculus 62-65 18199100-1 2008 AIM: To evaluate the association between primary vesicoureteral reflux (VUR) and renal scarring in children using 99 m Technetium-labelled dimercaptosuccinic acid (DMSA). Succimer 139-162 VUR Homo sapiens 72-75 18199100-1 2008 AIM: To evaluate the association between primary vesicoureteral reflux (VUR) and renal scarring in children using 99 m Technetium-labelled dimercaptosuccinic acid (DMSA). Succimer 164-168 VUR Homo sapiens 72-75 17940195-4 2008 We hypothesize that Mrp2 mediates the secretion of DMPS- or DMSA-S-conjugates of Hg(2+) from proximal tubular cells. Succimer 60-66 ATP binding cassette subfamily B member 4 Rattus norvegicus 20-24 17940195-14 2008 Experiments utilizing inside-out membrane vesicles expressing MRP2 support these observations by demonstrating that DMPS- and DMSA-S-conjugates of Hg(2+) are transportable substrates of MRP2. Succimer 126-132 ATP binding cassette subfamily C member 2 Rattus norvegicus 62-66 17940195-14 2008 Experiments utilizing inside-out membrane vesicles expressing MRP2 support these observations by demonstrating that DMPS- and DMSA-S-conjugates of Hg(2+) are transportable substrates of MRP2. Succimer 126-132 ATP binding cassette subfamily C member 2 Rattus norvegicus 186-190 17940195-15 2008 Collectively, these data support a role for Mrp2 in the DMPS- and DMSA-mediated elimination of Hg(2+) from the kidney. Succimer 66-70 ATP binding cassette subfamily B member 4 Rattus norvegicus 44-48 17762443-0 2007 The potential role of Calcitonin Gene-Related Peptide (CGRP) in breast carcinogenesis and its correlation with 99mTc-(V)DMSA scintimammography. Succimer 120-124 calcitonin related polypeptide alpha Homo sapiens 22-53 17762443-0 2007 The potential role of Calcitonin Gene-Related Peptide (CGRP) in breast carcinogenesis and its correlation with 99mTc-(V)DMSA scintimammography. Succimer 120-124 calcitonin related polypeptide alpha Homo sapiens 55-59 17762443-10 2007 The diffuse 99mTc-(V)DMSA uptake exhibited significant, time-related L/B increase and a RR positively correlating with CGRP. Succimer 21-25 calcitonin related polypeptide alpha Homo sapiens 119-123 17762443-12 2007 CGRP also appears associated with 99mTc-(V)DMSA"s propensity to depict preinvasive pathologies. Succimer 43-47 calcitonin related polypeptide alpha Homo sapiens 0-4 17250996-3 2007 Subsequentially, the anti-human cardiac troponin I (cTnI) immunomagnetic nanoparticles (IMNPs) were prepared by grafting anti-human cTnI antibodies on the surface of DMSA-coated MNPs using the linker of EDC (1-ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride). Succimer 166-170 troponin I3, cardiac type Homo sapiens 52-56 17188624-6 2007 The sensitivity, specificity, positive and negative predictive values, and likelihood ratio negative for abnormalities on DMSA renal scans for detecting the the presence of VUR on VCUG were 88% (95% confidence interval [CI] = 73% to 100%), 36% (95% CI = 26% to 46%), 37% (95% CI = 27% to 46%), 88 % (95% CI = 73% to 100%), and 0.33 (95% CI = 0 to 0.88), respectively. Succimer 122-126 VUR Homo sapiens 173-176 17188940-6 2007 Treatment with DMSA was effective in increasing ALAD activity while, captopril was ineffective when given alone. Succimer 15-19 aminolevulinate dehydratase Rattus norvegicus 48-52 17846912-1 2007 AIM: We aimed to investigate in children with a history of acute pyelonephritis the influence of unilateral post-pyelonephritic renal scarring detected by DMSA scan on serum (S(CysC)) and urine cystatin C (U(CysC)) as well as upon other traditional markers of renal damage. Succimer 155-159 cystatin C Homo sapiens 194-204 18947678-14 2006 Other factors significantly involved in the resolution of VUR are voiding dysfunctional syndrome, bilateralism of reflux, and scarring on initial DMSA. Succimer 146-150 VUR Homo sapiens 58-61 17044453-17 2006 The authors found the correlation between severity of VUR and abnormal DMSA results on right and left kidneys (p = 0.001, p = 0.01). Succimer 71-75 VUR Homo sapiens 54-57 16168622-0 2006 2,3-Dimercaptopropanol, 2,3-dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid increase lead-induced inhibition of delta-aminolevulinate dehydratase in vitro and ex vivo. Succimer 66-98 aminolevulinate dehydratase Homo sapiens 135-168 16564690-3 2006 In this study, we have investigated the link between 99mTc-(V)-DMSA, an imaging agent used in Single Photon Emission Computed Tomography, cellular accumulation and the biological effects of imatinib mediated by PDGF-r in a human glioblastoma cell line U87-MG. Succimer 63-67 platelet derived growth factor receptor beta Homo sapiens 211-217 16564690-5 2006 99mTc-(V)-DMSA cellular uptake studies showed that the specific action of imatinib on PDGF-r signal pathway, in the human glioblastoma cell line U87-MG, could be followed by radioactive tracer. Succimer 10-14 platelet derived growth factor receptor beta Homo sapiens 86-92 16564690-6 2006 Furthermore, strong correlations between cellular 99mTc-(V)-DMSA uptake and the effect of imatinib therapy on U87-MG proliferation (r=0.896), invasion (r=0.621) and migration (r=0.822) were obtained, likewise for 99mTc-(V)-DMSA uptake and PDGF-r expression (r=0.958). Succimer 60-64 platelet derived growth factor receptor beta Homo sapiens 239-245 14758509-13 2004 Children with abnormal DMSA had a higher frequency of VUR than children with normal DMSA (48% vs 12%). Succimer 23-27 VUR Homo sapiens 54-57 16898514-9 2006 The incidence 3-4 grade in DMSA scan was significantly higher in pts with IV-V grade of VUR in comparison to pts with lower grade of VUR in group with and without voiding dysfunction. Succimer 27-31 VUR Homo sapiens 88-91 15998567-6 2005 Supplementation of DL-alpha-lipoic acid and meso 2,3 dimercapto succinic acid to arsenic fed rats significantly increased the activities of superoxide dismutase, catalase, glutathione peroxidase with elevation in the levels of reduced glutathione, total sulfhydryl, ascorbic acid and alpha-tocopherol. Succimer 44-77 catalase Rattus norvegicus 162-170 16252147-6 2005 Of the 65 kidneys with VUR, DMSA scintigram displayed normal findings in 29 cases (45%) and pathologic findings in 36 (55%). Succimer 28-32 VUR Homo sapiens 23-26 16252147-10 2005 A significant correlation was found between maximum longitudinal diameters and DMSA scintigraphic findings in kidneys with VUR and those without VUR, respectively. Succimer 79-83 VUR Homo sapiens 123-126 16252147-10 2005 A significant correlation was found between maximum longitudinal diameters and DMSA scintigraphic findings in kidneys with VUR and those without VUR, respectively. Succimer 79-83 VUR Homo sapiens 145-148 15331134-5 2004 DMSA (400 micromol/Kg) and (PhSe)2 (100 micromol/Kg) protected inhibitory effect of 2.5 mg/kg CdCl2 on delta-ALA-D and restored the increase of TBARS levels. Succimer 0-4 aminolevulinate, delta-, dehydratase Mus musculus 103-114 15034164-10 2004 A good correlation between DMSA grading, single kidney clearance and VUR grade was shown. Succimer 27-31 VUR Homo sapiens 69-72 16649521-23 2006 Other relevant factors implied in the endoscopic resolution of VUR include the existence of voiding dysfunction, bilateral reflux and renal damage determined by DMSA at the time of initial diagnosis. Succimer 161-165 VUR Homo sapiens 63-66 15785954-3 2005 We hypothesised the existence of a correlation between V DMSA, whose uptake is linked to phosphate ions, essential compounds for tumour growth and cell proliferation, and the adhesion protein FAK, whose elevated expression and level of constitutive activation are implicated in cancer progression. Succimer 57-61 protein tyrosine kinase 2 Homo sapiens 192-195 15785954-4 2005 The aim of this study was to assess the relationship between V DMSA incorporation rate and FAK expression and activation by phosphorylation on tyrosine 397 residue. Succimer 63-67 protein tyrosine kinase 2 Homo sapiens 91-94 15785954-9 2005 A correlation was observed between V DMSA uptake and level of FAK phosphorylation and between V DMSA or constitutive FAK activation and proliferation rate. Succimer 37-41 protein tyrosine kinase 2 Homo sapiens 62-65 15785954-11 2005 CONCLUSION: The results of this in vitro study clearly demonstrate that phosphorylation of FAK, proliferation rate and V DMSA uptake are closely related. Succimer 121-125 protein tyrosine kinase 2 Homo sapiens 91-94 15785954-12 2005 Because proliferation and a high level of constitutive FAK activation are linked to cancer progression, it can be assumed that in vivo V DMSA uptake reflects tumour aggressiveness. Succimer 137-141 protein tyrosine kinase 2 Homo sapiens 55-58 15868848-13 2004 Thirty-three point two percent of the patients with acute pyelonephritis, confirmed by 99mTc dimercaptosuccinic acid (DMSA) renal scan, had VUR. Succimer 93-116 VUR Homo sapiens 140-143 15868848-13 2004 Thirty-three point two percent of the patients with acute pyelonephritis, confirmed by 99mTc dimercaptosuccinic acid (DMSA) renal scan, had VUR. Succimer 118-122 VUR Homo sapiens 140-143 15868848-18 2004 A positive DMSA renal scan finding was a good indicator for prediction the possibility of VUR in UTI patients. Succimer 11-15 VUR Homo sapiens 90-93 15311040-1 2004 PURPOSE: We study the ability of dimercapto-succinic acid (DMSA) scintigraphy to predict the presence of dilating vesicoureteral reflux (VUR) in infants with urinary tract infection (UTI) to simplify the evaluation protocol. Succimer 33-57 VUR Homo sapiens 137-140 15311040-1 2004 PURPOSE: We study the ability of dimercapto-succinic acid (DMSA) scintigraphy to predict the presence of dilating vesicoureteral reflux (VUR) in infants with urinary tract infection (UTI) to simplify the evaluation protocol. Succimer 59-63 VUR Homo sapiens 137-140 14758509-15 2004 Children with normal follow-up DMSA and low-grade VUR have more frequent spontaneous resolution of VUR. Succimer 31-35 VUR Homo sapiens 99-102 15171566-4 2004 Only DMSA was able to increase the activity of ALAD, while both taurine and DMSA were able to significantly increase GSH level towards normal. Succimer 5-9 aminolevulinate dehydratase Rattus norvegicus 47-51 15202869-1 2004 OBJECTIVE: The objective of this study was to investigate arsenic induced changes in blood delta-aminolevulinic acid dehydratase (ALAD) after in vitro and in vivo exposure to this element and its response to co-administration of meso 2,3-dimercaptosuccinic acid (DMSA) and monoisoamyl DMSA (MiADMSA) either individually or in combination. Succimer 229-261 aminolevulinate dehydratase Rattus norvegicus 91-128 15202869-1 2004 OBJECTIVE: The objective of this study was to investigate arsenic induced changes in blood delta-aminolevulinic acid dehydratase (ALAD) after in vitro and in vivo exposure to this element and its response to co-administration of meso 2,3-dimercaptosuccinic acid (DMSA) and monoisoamyl DMSA (MiADMSA) either individually or in combination. Succimer 229-261 aminolevulinate dehydratase Rattus norvegicus 130-134 15202869-11 2004 Another important toxicological finding of the present study, based on in vivo experiments further suggests that combined administration of DMSA and MiADMSA could be more beneficial for reducing blood ALAD inhibition and blood arsenic concentration than the individual treatment. Succimer 140-144 aminolevulinate dehydratase Rattus norvegicus 201-205 15202869-1 2004 OBJECTIVE: The objective of this study was to investigate arsenic induced changes in blood delta-aminolevulinic acid dehydratase (ALAD) after in vitro and in vivo exposure to this element and its response to co-administration of meso 2,3-dimercaptosuccinic acid (DMSA) and monoisoamyl DMSA (MiADMSA) either individually or in combination. Succimer 263-267 aminolevulinate dehydratase Rattus norvegicus 91-128 15202869-1 2004 OBJECTIVE: The objective of this study was to investigate arsenic induced changes in blood delta-aminolevulinic acid dehydratase (ALAD) after in vitro and in vivo exposure to this element and its response to co-administration of meso 2,3-dimercaptosuccinic acid (DMSA) and monoisoamyl DMSA (MiADMSA) either individually or in combination. Succimer 263-267 aminolevulinate dehydratase Rattus norvegicus 130-134 15202869-1 2004 OBJECTIVE: The objective of this study was to investigate arsenic induced changes in blood delta-aminolevulinic acid dehydratase (ALAD) after in vitro and in vivo exposure to this element and its response to co-administration of meso 2,3-dimercaptosuccinic acid (DMSA) and monoisoamyl DMSA (MiADMSA) either individually or in combination. Succimer 285-289 aminolevulinate dehydratase Rattus norvegicus 91-128 15202869-1 2004 OBJECTIVE: The objective of this study was to investigate arsenic induced changes in blood delta-aminolevulinic acid dehydratase (ALAD) after in vitro and in vivo exposure to this element and its response to co-administration of meso 2,3-dimercaptosuccinic acid (DMSA) and monoisoamyl DMSA (MiADMSA) either individually or in combination. Succimer 285-289 aminolevulinate dehydratase Rattus norvegicus 130-134 15202869-4 2004 In vitro and in vivo experiments were also conducted to determine the effects of DMSA and MiADMSA either individually or in combination with arsenic, on blood ALAD activity and blood arsenic concentration. Succimer 81-85 aminolevulinate dehydratase Rattus norvegicus 159-163 15202869-9 2004 DMSA at all the three concentrations (0.1, 0.5 and 1.0 mmol/L) was effective in restoring ALAD activity to the normal value. Succimer 0-4 aminolevulinate dehydratase Rattus norvegicus 90-94 15016592-8 2004 The preincubation of dithiol chelating agents with enzyme demonstrated that DMSA was the most potent delta-ALA-D inhibitor of human erythrocytes. Succimer 76-80 aminolevulinate dehydratase Homo sapiens 101-112 12754110-8 2003 Preincubation of VSMCs with DMSA (10(-6)M) for 60min reduced basal [Ca(2+)](i) by 77% (P<0.001) and dose-dependently attenuated the ANG II (10(-8)M)-induced rise in [Ca(2+)](i) between 28 and 69% at concentrations between 10(-9) and 10(-5)M DMSA, respectively (P<0.05 and <0.01). Succimer 28-32 angiotensinogen Rattus norvegicus 135-141 14519305-4 2003 METHODS: We retrospectively reviewed the DMSA renal scans of infants with VUR without a history of urinary tract infection (UTI). Succimer 41-45 VUR Homo sapiens 74-77 14519305-8 2003 DMSA revealed parenchymal abnormalities in 50% (9/18) of the patients and in 33% (9/27) of the renal units with VUR; most of the patients were boys (7 boys, 2 girls) with VUR grade V or IV (6/9; 66%). Succimer 0-4 VUR Homo sapiens 171-174 14519305-12 2003 Therefore, we recommend DMSA scanning in the initial evaluation of infants with VUR. Succimer 24-28 VUR Homo sapiens 80-83 14501662-13 2003 Our findings endorse the usefulness of DMSA scan in tailoring management of VUR and breakthrough UTI cases, and lend support to continued nonoperative management for the majority. Succimer 39-43 VUR Homo sapiens 76-79 15016592-0 2004 2,3-Dimercaptopropanol, 2,3-dimercaptopropane-1-sulfonic acid, and meso-2,3-dimercaptosuccinic acid inhibit delta-aminolevulinate dehydratase from human erythrocytes in vitro. Succimer 67-99 aminolevulinate dehydratase Homo sapiens 108-141 15555419-10 2004 DMSA, on the other hand when given alone, provided significant recovery in restoring the altered lead sensitive biochemical indices like blood delta-aminolevulinic acid dehydratase (ALAD), urinary delta-aminolevulinic acid (ALA), beside increasing urinary lead excretion and decreasing lead concentration in blood and soft tissues. Succimer 0-4 aminolevulinate dehydratase Rattus norvegicus 143-180 15555419-10 2004 DMSA, on the other hand when given alone, provided significant recovery in restoring the altered lead sensitive biochemical indices like blood delta-aminolevulinic acid dehydratase (ALAD), urinary delta-aminolevulinic acid (ALA), beside increasing urinary lead excretion and decreasing lead concentration in blood and soft tissues. Succimer 0-4 aminolevulinate dehydratase Rattus norvegicus 182-186 14527840-6 2003 We observed effect modification by ALAD on associations between blood lead and/or DMSA-chelatable lead and three renal outcomes. Succimer 82-86 aminolevulinate dehydratase Homo sapiens 35-39 12754110-0 2003 Interaction of dimercaptosuccinic acid (DMSA) with angiotensin II on calcium mobilization in vascular smooth muscle cells. Succimer 15-38 angiotensinogen Rattus norvegicus 51-65 12754110-0 2003 Interaction of dimercaptosuccinic acid (DMSA) with angiotensin II on calcium mobilization in vascular smooth muscle cells. Succimer 40-44 angiotensinogen Rattus norvegicus 51-65 12754110-9 2003 In the presence of TMB-8, which attenuated the ANG II (10(-8)M)-induced rise in [Ca(2+)](i) by 66%, DMSA (10(-6)M) had no additional suppressive effect on [Ca(2+)](i). Succimer 100-104 angiotensinogen Rattus norvegicus 47-53 12754110-11 2003 Thus, in addition to its action as scavenger of ROS, which in part mediate the vasoconstrictor response, e.g. to ANG II, DMSA may exert its hypotensive effect through decreasing total cell calcium, thereby attenuating the vasoconstrictor-induced rise in [Ca(2+)](i) in VSMCs. Succimer 121-125 angiotensinogen Rattus norvegicus 113-119 12605306-6 2003 The Na(+)-dicarboxylate cotransporter 3 (NaDC-3) was cloned from human, rat, mouse and flounder, and transported three Na(+) with one divalent di- or tricarboxylate, such as citric acid cycle intermediates and the heavy metal chelator 2,3-dimercaptosuccinate (succimer). Succimer 260-268 solute carrier family 13 member 3 Homo sapiens 4-39 12499112-0 2003 2,3-Dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid increase mercury- and cadmium-induced inhibition of delta-aminolevulinate dehydratase. Succimer 42-74 aminolevulinate dehydratase Homo sapiens 127-160 12499112-5 2003 DMPS and DMSA caused a dose-dependent inhibition of hepatic delta-ALA-D. Succimer 9-13 aminolevulinate dehydratase Homo sapiens 60-71 12499112-10 2003 Data of the present report support the idea that the complexes formed (metals-DMSA or DMPS) were more inhibitory than the metal (Hg(2+) and Cd(2+)) or the chelating agent alone to the hepatic delta-ALA-D activity, in vitro. Succimer 78-82 aminolevulinate dehydratase Homo sapiens 192-203 12499112-11 2003 The mechanism of hepatic delta-ALA-D inhibition by Hg(2+)-DMPS/DMSA and Cd(2+)-DMPS/DMSA complexes involve the essential thiol groups of the enzyme. Succimer 63-67 aminolevulinate dehydratase Homo sapiens 25-36 12499112-11 2003 The mechanism of hepatic delta-ALA-D inhibition by Hg(2+)-DMPS/DMSA and Cd(2+)-DMPS/DMSA complexes involve the essential thiol groups of the enzyme. Succimer 84-88 aminolevulinate dehydratase Homo sapiens 25-36 12605306-6 2003 The Na(+)-dicarboxylate cotransporter 3 (NaDC-3) was cloned from human, rat, mouse and flounder, and transported three Na(+) with one divalent di- or tricarboxylate, such as citric acid cycle intermediates and the heavy metal chelator 2,3-dimercaptosuccinate (succimer). Succimer 260-268 solute carrier family 13 member 3 Homo sapiens 41-47 11511988-2 2001 In children with a positive DMSA scan, mean C-reactive protein (CRP) was higher than in children with a normal DMSA scan (114+/-64 vs. 67+/-38 mg/dl, mean+/-SD, P=0.0002). Succimer 28-32 C-reactive protein Homo sapiens 44-62 12359191-2 2002 The subsequent treatment of lead-exposed animals with DMSA, MiADMS, or NAC reversed the lead-induced alterations in blood delta-aminolevulinic acid dehydratase, catalase, malondialdehyde (MDA), reduced glutathione, oxidized glutathione, and brain MDA levels. Succimer 54-58 catalase Rattus norvegicus 161-169 12188413-6 2002 60.20 per cent of 98 positive 1st DMSA had VUR while 80.33 per cent of 61 with VUR had positive 1st DMSA. Succimer 100-104 VUR Homo sapiens 79-82 11953567-1 2002 PURPOSE: To describe and analyze the appearances of autosomal recessive polycystic kidney disease (ARPKD) on Tc-99m DMSA and Tc-99m HIDA scintigraphy. Succimer 116-120 PKHD1 ciliary IPT domain containing fibrocystin/polyductin Homo sapiens 99-104 11953567-8 2002 CONCLUSIONS: In a child with clinically enlarged kidneys that appear diffusely hyperechoic on ultrasound, the appearances on Tc-99m DMSA imaging strongly support the diagnosis of ARPKD. Succimer 132-136 PKHD1 ciliary IPT domain containing fibrocystin/polyductin Homo sapiens 179-184 12453590-5 2002 RESULTS: Tumor uptake was highest for F-18 FDG > Tc-99m (V)DMSA > Tc-99m MIBI. Succimer 62-66 mastermind like domain containing 1 Homo sapiens 38-42 12185410-8 2002 Nephrotoxic damage was evident from decreases in the activities of gamma-glutamyl transferase and N-acetyl beta- D-glucosaminidase, which were reversed upon combined treatment with LA and DMSA. Succimer 188-192 gamma-glutamyltransferase 1 Rattus norvegicus 67-93 12185410-8 2002 Nephrotoxic damage was evident from decreases in the activities of gamma-glutamyl transferase and N-acetyl beta- D-glucosaminidase, which were reversed upon combined treatment with LA and DMSA. Succimer 188-192 O-GlcNAcase Rattus norvegicus 98-130 11801699-7 2002 RESULTS: Temperature, neutrophil count, and C-reactive protein value were significantly higher in patients with abnormal DMSA 1 findings than in those with abnormal DS 1 findings (P < 0.05). Succimer 121-125 C-reactive protein Homo sapiens 44-62 12762236-2 2002 Dimercaptosuccinil acid (DMSA) scan was used based on the relation between vesicoureteral reflux (VUR), infection of the urinary tract (UTI) and parenchymal kidney damage. Succimer 25-29 VUR Homo sapiens 75-96 12762236-2 2002 Dimercaptosuccinil acid (DMSA) scan was used based on the relation between vesicoureteral reflux (VUR), infection of the urinary tract (UTI) and parenchymal kidney damage. Succimer 25-29 VUR Homo sapiens 98-101 11511988-2 2001 In children with a positive DMSA scan, mean C-reactive protein (CRP) was higher than in children with a normal DMSA scan (114+/-64 vs. 67+/-38 mg/dl, mean+/-SD, P=0.0002). Succimer 28-32 C-reactive protein Homo sapiens 64-67 11234755-2 2001 This article is a report on the effects of BAL and other dithiols, DMSA (meso-2,3-dimercaptosuccinic acid) and DMPS (2,3-dimercaptopropane-1-sulfonic acid), on [3H]glutamate release and uptake by rat brain synaptosomes and [3H]glutamate uptake by synaptic vesicles. Succimer 73-105 solute carrier family 27 member 5 Rattus norvegicus 43-46 11519895-1 2001 We studied the insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene in 78 patients with primary vesicoureteral reflux (VUR), and examined renal function by dimercaptosuccinate (DMSA) renoscintigraphy and diethylenetriamine-penta-acetic acid (DTPA) renogram in each genotype. Succimer 210-214 angiotensin I converting enzyme Homo sapiens 91-94 11259232-0 2001 An audit of RCP guidelines on DMSA scanning after urinary tract infection. Succimer 30-34 CGRP receptor component Homo sapiens 12-15 11049814-0 2000 Associations of blood lead, dimercaptosuccinic acid-chelatable lead, and tibia lead with polymorphisms in the vitamin D receptor and [delta]-aminolevulinic acid dehydratase genes. Succimer 28-51 vitamin D receptor Homo sapiens 110-128 11292581-2 2001 The results suggest that concomitant oral supplementation of DMSA with lead was most effective in preventing the inhibition of lead sensitive blood delta-aminolevulinic acid dehydratase (ALAD) activity in blood, elevation of zinc protoporphyrin level and the alterations in hepatic reduced and oxidized glutathione (GSH and GSSG) contents. Succimer 61-65 aminolevulinate dehydratase Rattus norvegicus 148-185 11292581-2 2001 The results suggest that concomitant oral supplementation of DMSA with lead was most effective in preventing the inhibition of lead sensitive blood delta-aminolevulinic acid dehydratase (ALAD) activity in blood, elevation of zinc protoporphyrin level and the alterations in hepatic reduced and oxidized glutathione (GSH and GSSG) contents. Succimer 61-65 aminolevulinate dehydratase Rattus norvegicus 187-191 11166893-0 2001 Novel use of anaerobically induced promoter, dmsA, for controlled expression of fragment C of tetanus toxin in live attenuated Salmonella enterica serovar Typhi strain CVD 908-htrA. Succimer 45-49 HtrA serine peptidase 1 Mus musculus 176-180 10835062-8 2000 Renal atrophy or scars, as demonstrated by DMSA scan, were detected almost exclusively in neonates with VUR grade 3 and above. Succimer 43-47 VUR Homo sapiens 104-107 10961818-2 2000 To ascertain the colony-forming units (CFU)/mL compatible with the diagnosis of UTI, a culture from a catheterized urine specimen containing >1,000 CFU/mL was considered diagnostic of UTI and resulted in imaging by renal ultrasound, voiding cystourethrography, and renal nuclear scan with Tc99m dimercaptosuccinic acid (DMSA). Succimer 298-321 alpha-1-microglobulin/bikunin precursor Homo sapiens 80-83 10961818-2 2000 To ascertain the colony-forming units (CFU)/mL compatible with the diagnosis of UTI, a culture from a catheterized urine specimen containing >1,000 CFU/mL was considered diagnostic of UTI and resulted in imaging by renal ultrasound, voiding cystourethrography, and renal nuclear scan with Tc99m dimercaptosuccinic acid (DMSA). Succimer 323-327 alpha-1-microglobulin/bikunin precursor Homo sapiens 80-83 10561806-14 1999 Only DMSA appeared to restore blood ALAD, while RBC MDA levels responded favourably to both drugs. Succimer 5-9 aminolevulinate dehydratase Rattus norvegicus 36-40 10799427-1 2000 AIMS: To address some of the issues in the ongoing debate over the optimal diagnostic imaging following childhood urinary tract infection (UTI), by determining the risk of missing renal cortical scarring which would be detected on a technetium-99m dimercaptosuccinic acid (DMSA) gold standard if ultrasound alone were used, factoring for clinical features (upper or lower tract), UTI recurrence, and age group (infants, preschool, or school age). Succimer 248-271 alpha-1-microglobulin/bikunin precursor Homo sapiens 139-142 10799427-1 2000 AIMS: To address some of the issues in the ongoing debate over the optimal diagnostic imaging following childhood urinary tract infection (UTI), by determining the risk of missing renal cortical scarring which would be detected on a technetium-99m dimercaptosuccinic acid (DMSA) gold standard if ultrasound alone were used, factoring for clinical features (upper or lower tract), UTI recurrence, and age group (infants, preschool, or school age). Succimer 273-277 alpha-1-microglobulin/bikunin precursor Homo sapiens 139-142 10799427-4 2000 CONCLUSIONS: UTI clinical features are important in assessing the need for DMSA imaging. Succimer 75-79 alpha-1-microglobulin/bikunin precursor Homo sapiens 13-16 10353409-6 1999 Among those children with VUR, 4 had a normal DMSA scan, 2 an abnormal RUS, and 2 a normal DMSA scan and RUS. Succimer 46-50 VUR Homo sapiens 26-29 9559101-4 1998 The activity of blood ALAD was significantly increased by the administration of DMSA and SAM while DMPS had only a moderate effect. Succimer 80-84 aminolevulinate, delta-, dehydratase Mus musculus 22-26 10199582-9 1999 The DMSA-exposed offspring also demonstrated increased interleukin-2 (IL-2) production. Succimer 4-8 interleukin 2 Rattus norvegicus 55-68 10199582-9 1999 The DMSA-exposed offspring also demonstrated increased interleukin-2 (IL-2) production. Succimer 4-8 interleukin 2 Rattus norvegicus 70-74 9408648-0 1997 Neurofibromatosis type 2 (bilateral acoustic schwannomas) demonstrated by Tc-99m (V) DMSA SPECT. Succimer 85-89 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Homo sapiens 0-24 9649287-9 1998 RESULTS: Levels of serum soluble interleukin-2 receptor in the patients who had low total uptake of DMSA (right uptake plus left uptake) were significantly higher than those from patients with normal total uptake. Succimer 100-104 interleukin 2 Homo sapiens 33-46 9649287-11 1998 A significant negative correlation was observed between levels of serum soluble interleukin-2 receptor and total DMSA uptake values (right uptake plus left uptake r=-0.678, p <0.0001). Succimer 113-117 interleukin 2 Homo sapiens 80-93 9408648-1 1997 Tc-99m (V) DMSA clearly demonstrated several cranial meningiomas, bilateral acoustic neurinomas and multiple subcutaneous neurofibromas in a patient of neurofibromatosis type 2 (NF-2). Succimer 11-15 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Homo sapiens 152-176 9408648-1 1997 Tc-99m (V) DMSA clearly demonstrated several cranial meningiomas, bilateral acoustic neurinomas and multiple subcutaneous neurofibromas in a patient of neurofibromatosis type 2 (NF-2). Succimer 11-15 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Homo sapiens 178-182 9194404-6 1997 Chelation (DMSA, 50 mg/kg po, 3 times/week for 21 days) decreased the BPb concentration, and prevented and reversed the Pb-induced changes in GFAP and rearing, but not in body weight. Succimer 11-15 glial fibrillary acidic protein Rattus norvegicus 142-146 9202621-7 1997 Elevation of alanine aminotransferase and vomiting during therapy were observed more frequently in the BAL + EDTA group compared with the DMSA + EDTA group. Succimer 138-142 glutamic--pyruvic transaminase Homo sapiens 13-37 9528168-6 1997 DMSA either in free form or encapsulated in liposomes also restored the inhibition in blood delta-aminolevulinic acid dehydratase (delta-ALAD) activity. Succimer 0-4 aminolevulinate, delta-, dehydratase Mus musculus 92-129 9528168-6 1997 DMSA either in free form or encapsulated in liposomes also restored the inhibition in blood delta-aminolevulinic acid dehydratase (delta-ALAD) activity. Succimer 0-4 aminolevulinate, delta-, dehydratase Mus musculus 131-141 9146653-7 1997 There were low levels of urinary epidermal growth factor in 20 of the 44 patients (45%) with unilateral low DMSA uptake and 18 of the 19 (95%) with low total DMSA uptake (right and left uptakes). Succimer 108-112 epidermal growth factor Homo sapiens 33-56 9146653-8 1997 Urinary epidermal growth factor significantly correlated with serum creatinine (R = -0.702, p < 0.0001), urinary alpha 1-microglobulin (R = -0.606, p < 0.0001), urinary microalbumin (R = -0.708, p < 0.0001) and total DMSA uptake (R = 0.744, p < 0.0001). Succimer 226-230 epidermal growth factor Homo sapiens 8-31 21781736-8 1996 Biochemical variables, on the other hand, responded less favorably to the treatment of DMSA or DMPS except for a significant recovery in the activity of blood delta-aminolevulinic acid dehydratase (ALAD) following DMSA administration. Succimer 214-218 aminolevulinate dehydratase Rattus norvegicus 159-196 9140137-6 1997 Rac-DMSA is more soluble than meso-DMSA in acetonitrile, ethyl acetate, and ethyl ether. Succimer 4-8 Rac family small GTPase 2 Rattus norvegicus 0-3 9140137-7 1997 The partition coefficient of rac-DMSA in the n-octanol/water system was found to be about 2.8. Succimer 33-37 Rac family small GTPase 2 Rattus norvegicus 29-32 9140137-8 1997 These results indicate that rac-DMSA deserves further attention as a possible substitute for meso-DMSA. Succimer 32-36 Rac family small GTPase 2 Rattus norvegicus 28-31 9166129-0 1997 delta-Aminolevulinic acid dehydratase genotype modifies four hour urinary lead excretion after oral administration of dimercaptosuccinic acid. Succimer 118-141 delta-aminolevulinic acid dehydratase, chloroplastic-like Nicotiana tabacum 0-37 9166129-10 1997 ALAD genotype seemed to modify the relation between plasma delta-aminolevulinic acid (ALA) and DMSA chelatable lead. Succimer 95-99 delta-aminolevulinic acid dehydratase, chloroplastic-like Nicotiana tabacum 0-4 21781736-8 1996 Biochemical variables, on the other hand, responded less favorably to the treatment of DMSA or DMPS except for a significant recovery in the activity of blood delta-aminolevulinic acid dehydratase (ALAD) following DMSA administration. Succimer 214-218 aminolevulinate dehydratase Rattus norvegicus 198-202 9004280-1 1996 We propose a renal imaging agent, the 99mTc complex of the bidentate-N,S chelate N-(mercaptoacetyl)glycine (99mTc-2GAM), with the imaging characteristics of 99mTc-DMSA but a faster kidney uptake; chemical evidence supports the formulation of 99mTc-2GAM as [Tc(v)(O)(GAM)2]-. Succimer 162-167 transcobalamin 2 Mus musculus 110-115 7794724-2 1995 Indications for DMSA scanning in children with urinary tract infection (UTI), as well as timing, have changed. Succimer 16-20 alpha-1-microglobulin/bikunin precursor Homo sapiens 72-75 7776550-1 1995 99mTc-2,3-di-mercapto-succinic acid (DMSA) is able to be used for the quantitative analysis of individual renal function by calculating the uptake ratio. Succimer 37-41 transcobalamin 2 Mus musculus 2-7 8965153-13 1996 This study also suggests that VUR is almost certain to have occurred in a child who has bilateral abnormal 99mTc-DMSA images following UTI and is also commonly present in those with definite unilateral defects. Succimer 113-117 VUR Homo sapiens 30-33 8740300-5 1996 C-reactive protein and grade of reflux correlated significantly with abnormal DMSA studies. Succimer 78-82 C-reactive protein Homo sapiens 0-18 7794724-4 1995 Interpretation of DMSA scans in children with UTI vary according to timing and clinical setting. Succimer 18-22 alpha-1-microglobulin/bikunin precursor Homo sapiens 46-49 7794724-5 1995 During the course of a febrile UTI a DMSA scan may reveal a normal kidney, APN or a non-functioning, small and/or ectopic kidney. Succimer 37-41 alpha-1-microglobulin/bikunin precursor Homo sapiens 31-34 7794724-12 1995 An abnormal DMSA scan during a febrile UTI allows the identification of children at risk of developing renal scars. Succimer 12-16 alpha-1-microglobulin/bikunin precursor Homo sapiens 39-42 7696531-2 1994 The complexes formed with zinc(II) and the ligands rac-DMSA and meso-DMSA have been postulated from potentiometric titrations of solutions containing varying ratios of zinc:ligand. Succimer 55-59 Rac family small GTPase 2 Homo sapiens 51-54 7696107-9 1994 The urine NAG/creatinine quotient in the children < 1 year showed, however, a significant correlation with the DMSA score (r = 0.58, P < 0.05), while no correlation was found in the older children. Succimer 114-118 O-GlcNAcase Homo sapiens 10-13 7716789-2 1995 Of these, CaNa2EDTA and dimercaprol (British anti-lewisite, BAL) are becoming outmoded and can be expected to be replaced by meso-2,3-dimercaptosuccinic acid (DMSA, succimer) for treatment of lead intoxication and by the sodium salt of 2,3-dimercapto-1-propanesulfonic acid (DMPS, Dimaval) for treating lead, mercury or arsenic intoxication. Succimer 165-173 poly(ADP-ribose) polymerase family member 9 Homo sapiens 60-63 7696531-5 1994 On the basis of these results we have predicted that rac-DMSA is more effective than meso-DMSA in mobilizing lead in vivo and that the 1:2 zinc complex of rac-DMSA can be used effectively for the treatment of heavy metal poisoning because endogenous zinc will not be depleted by this chelation treatment. Succimer 57-61 Rac family small GTPase 2 Homo sapiens 53-56 7696531-5 1994 On the basis of these results we have predicted that rac-DMSA is more effective than meso-DMSA in mobilizing lead in vivo and that the 1:2 zinc complex of rac-DMSA can be used effectively for the treatment of heavy metal poisoning because endogenous zinc will not be depleted by this chelation treatment. Succimer 57-61 Rac family small GTPase 2 Homo sapiens 155-158 7696547-1 1994 rac-2,3-Dimercaptosuccinic acid (DMSA) was found to be superior to meso-2,3-dimercaptosuccinc acid in mobilizing in vivo heavy metals such as Cd, Hg, and Pb. Succimer 33-37 Rac family small GTPase 2 Homo sapiens 0-5 7696547-4 1994 The zinc complexes of rac-DMSA in aqueous solution are more stable than the corresponding complexes of its meso isomer because the rac-DMSA ligands always adopt staggered anti conformations, in which the electrostatic repulsion between two bulky carboxylate groups is minimized; in contrast, unlike in the crystal lattice, meso-DMSA ligands always adopt staggered gauche conformations in their zinc complexes. Succimer 26-30 Rac family small GTPase 2 Homo sapiens 22-25 7696547-4 1994 The zinc complexes of rac-DMSA in aqueous solution are more stable than the corresponding complexes of its meso isomer because the rac-DMSA ligands always adopt staggered anti conformations, in which the electrostatic repulsion between two bulky carboxylate groups is minimized; in contrast, unlike in the crystal lattice, meso-DMSA ligands always adopt staggered gauche conformations in their zinc complexes. Succimer 26-30 Rac family small GTPase 2 Homo sapiens 131-134 7696547-4 1994 The zinc complexes of rac-DMSA in aqueous solution are more stable than the corresponding complexes of its meso isomer because the rac-DMSA ligands always adopt staggered anti conformations, in which the electrostatic repulsion between two bulky carboxylate groups is minimized; in contrast, unlike in the crystal lattice, meso-DMSA ligands always adopt staggered gauche conformations in their zinc complexes. Succimer 135-139 Rac family small GTPase 2 Homo sapiens 22-25 7696547-4 1994 The zinc complexes of rac-DMSA in aqueous solution are more stable than the corresponding complexes of its meso isomer because the rac-DMSA ligands always adopt staggered anti conformations, in which the electrostatic repulsion between two bulky carboxylate groups is minimized; in contrast, unlike in the crystal lattice, meso-DMSA ligands always adopt staggered gauche conformations in their zinc complexes. Succimer 135-139 Rac family small GTPase 2 Homo sapiens 131-134 7696547-6 1994 rac-DMSA in ZnL2(6-) coordinates with zinc ion via two thiolate groups and one carboxylate group, whereas in Zn2L2(4-) each ligand complexes two zinc ions by using one carboxylate group and one thiolate group in the beta-position to bind to the same zinc ion. Succimer 4-8 Rac family small GTPase 2 Homo sapiens 0-3 1282579-4 1992 Among the patients of one year and up, those with low preoperative DMSA uptake rate tended to have high values of beta 2-MG, alpha 1-MG and NAG. Succimer 67-71 beta-2-microglobulin Homo sapiens 114-123 8199302-3 1994 The structures of rac-DMSA and the precursor in its synthesis, rac-2,3-bis(acetylthio)succinic acid, have been determined by single-crystal X-ray analysis and compared with the structures of the corresponding meso compounds. Succimer 22-26 Rac family small GTPase 2 Homo sapiens 63-68 8199302-8 1994 These differences in the conformations of rac- and meso-DMSA may account for the significant difference in the solubilities of the two compounds in aqueous solutions. Succimer 56-60 Rac family small GTPase 2 Homo sapiens 42-45 8239890-12 1993 CONCLUSIONS: DMSA scans are useful for investigating and following UTI. Succimer 13-17 alpha-1-microglobulin/bikunin precursor Homo sapiens 67-70 1282579-4 1992 Among the patients of one year and up, those with low preoperative DMSA uptake rate tended to have high values of beta 2-MG, alpha 1-MG and NAG. Succimer 67-71 O-GlcNAcase Homo sapiens 140-143 1282579-6 1992 With respect to the relation between pre- and postoperative changes in DMSA uptake rate and each index, beta 2-MG and alpha 1-MG were high in 73% and 62% of patients who exhibited a marked increase in postoperative DMSA uptake rate. Succimer 215-219 beta-2-microglobulin Homo sapiens 104-113 1664200-7 1991 Treatment with D-PEN, DMSA, DMPS, and bucillamine (1.2 mmol/kg) significantly prevented increases in the urinary excretion of protein, AST, and glucose and the BUN level after AuTM (0.026 mmol/kg) injection. Succimer 22-26 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 135-138 1327798-6 1992 Although fever, leucocytosis and elevated CRP and ESR were significantly correlated with abnormal 99mTc DMSA scan, they were also observed in children without renal parenchymal involvement. Succimer 104-108 C-reactive protein Homo sapiens 42-45 1343562-8 1992 During infection the size of the defect on the DMSA scan correlated with renal volume and C-reactive protein and inversely with the glomerular filtration rate, and at follow-up it correlated inversely with the renal concentration capacity. Succimer 47-51 C-reactive protein Homo sapiens 90-108 1311185-2 1992 A retrospective review of a large series of patients with urinary tract disorders at the hospital for Sick Children, Great Ormond Street, identified 12 patients with vesico-ureteric reflux (VUR) with no evidence of scarring but with renal damage as assessed using technetium 99m dimercaptosuccinic acid (99mTc-DMSA) scan. Succimer 279-302 VUR Homo sapiens 190-193 1665353-0 1991 The dimethyl ester of meso-2,3-dimercaptosuccinic acid and its interactions with Cd2+ and rabbit liver metallothionein I. Succimer 22-54 T-cell surface antigen CD2 Oryctolagus cuniculus 81-84 1850782-5 1991 The isomers arise from differing orientations of the carboxylate groups in the DMSA ligands and may be designated syn-endo, syn-exo, and anti. Succimer 79-83 synemin Homo sapiens 114-117 1850782-5 1991 The isomers arise from differing orientations of the carboxylate groups in the DMSA ligands and may be designated syn-endo, syn-exo, and anti. Succimer 79-83 synemin Homo sapiens 124-127 2162508-1 1990 Technetium-99m (99Tcm) (v) dimercaptosuccinic acid (DMSA) is a new tumour imaging agent which has been used to image medullary carcinoma of the thyroid and squamous cell carcinoma (SCC) of the head and neck. Succimer 27-50 serpin family B member 3 Homo sapiens 181-184 2173085-2 1990 It was found that BAL (2,3-dimercaptopropanol) and DMPS (2,3-dimercaptopropanesulfonic acid) had a higher affinity than DMSA (2,3-dimercaptosuccinic acid) for the two organic arsenicals studied. Succimer 120-124 solute carrier family 27 member 5 Homo sapiens 18-21 2173085-2 1990 It was found that BAL (2,3-dimercaptopropanol) and DMPS (2,3-dimercaptopropanesulfonic acid) had a higher affinity than DMSA (2,3-dimercaptosuccinic acid) for the two organic arsenicals studied. Succimer 126-153 solute carrier family 27 member 5 Homo sapiens 18-21 2170881-1 1990 Technetium-99m(99Tcm) (V) dimercaptosuccinic acid is a new imaging agent which has been used to evaluate head and neck squamous cell carcinoma (SCC). Succimer 26-49 serpin family B member 3 Homo sapiens 144-147 2170881-7 1990 These results show that although 99Tcm(V)DMSA is accumulated at sites of SCC, the localization process is nonspecific. Succimer 41-45 serpin family B member 3 Homo sapiens 73-76 2164650-1 1990 Technetium-99m (99Tcm)(V) dimercaptosuccinic acid (DMSA) is a new tumour imaging agent which has been used to evaluate squamous carcinoma (SCC) of the head and neck. Succimer 26-49 serpin family B member 3 Homo sapiens 139-142 2164650-1 1990 Technetium-99m (99Tcm)(V) dimercaptosuccinic acid (DMSA) is a new tumour imaging agent which has been used to evaluate squamous carcinoma (SCC) of the head and neck. Succimer 51-55 serpin family B member 3 Homo sapiens 139-142 2197478-11 1990 In many cases, in which urinary beta 2-MG was more than 1.0, improvement of DMSA uptake rate was noticed after antireflux operation. Succimer 76-80 beta-2-microglobulin Homo sapiens 32-41 2162508-1 1990 Technetium-99m (99Tcm) (v) dimercaptosuccinic acid (DMSA) is a new tumour imaging agent which has been used to image medullary carcinoma of the thyroid and squamous cell carcinoma (SCC) of the head and neck. Succimer 52-56 serpin family B member 3 Homo sapiens 181-184 2162509-1 1990 Technetium-99m (99Tcm) (v) dimercaptosuccinic acid (DMSA) is a new tumour imaging agent which has been used to image squamous cell carcinoma (SCC) of the head and neck. Succimer 27-50 serpin family B member 3 Homo sapiens 142-145 2162509-1 1990 Technetium-99m (99Tcm) (v) dimercaptosuccinic acid (DMSA) is a new tumour imaging agent which has been used to image squamous cell carcinoma (SCC) of the head and neck. Succimer 52-56 serpin family B member 3 Homo sapiens 142-145 2162509-2 1990 This study was undertaken to compare planar versus SPECT 99Tcm (v) DMSA scintigraphy in patients with head and neck SCC. Succimer 67-71 serpin family B member 3 Homo sapiens 116-119 2169719-4 1990 Both DMPS and DMSA were significantly (p less than or equal to 0.05) more effective in mice treated 0.5 min after the poisoning if compared to BAL on an equimolar level. Succimer 14-18 desmoglein 3 Mus musculus 143-146 1967305-2 1990 Scintigraphy with 99mTc(V)-DMSA demonstrated uptake in medullary carcinoma of the thyroid gland (MCT). Succimer 27-31 solute carrier family 16 member 1 Homo sapiens 97-100 2155787-0 1990 Renal uptake of dimercaptosuccinic acid and glomerular filtration rate in chronic nephropathy at angiotensin converting enzyme inhibition. Succimer 16-39 angiotensin I converting enzyme Homo sapiens 97-126 2156706-6 1990 In patients who were candidates for surgical management of VUR, renal scars could be detected both by IVU and DMSA scan but, for the follow-up, the DMSA scan was found to be the investigation of choice. Succimer 110-114 VUR Homo sapiens 59-62 34775563-6 2022 The results of the present study showed that DMSA and FA decreased malondialdehyde (MDA) and Pb residue in tissues of Pb-exposed fish and improved the histologic picture and brain contents of glutathione (GSH), glutathione-s-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), G6PD, LDH, and total antioxidant capacity (TAC). Succimer 45-49 glutathione S-transferase Oreochromis niloticus 211-236 34775563-6 2022 The results of the present study showed that DMSA and FA decreased malondialdehyde (MDA) and Pb residue in tissues of Pb-exposed fish and improved the histologic picture and brain contents of glutathione (GSH), glutathione-s-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), G6PD, LDH, and total antioxidant capacity (TAC). Succimer 45-49 glutathione S-transferase Oreochromis niloticus 238-241 34775563-6 2022 The results of the present study showed that DMSA and FA decreased malondialdehyde (MDA) and Pb residue in tissues of Pb-exposed fish and improved the histologic picture and brain contents of glutathione (GSH), glutathione-s-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), G6PD, LDH, and total antioxidant capacity (TAC). Succimer 45-49 glutathione peroxidase Oreochromis niloticus 244-266 34775563-6 2022 The results of the present study showed that DMSA and FA decreased malondialdehyde (MDA) and Pb residue in tissues of Pb-exposed fish and improved the histologic picture and brain contents of glutathione (GSH), glutathione-s-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), G6PD, LDH, and total antioxidant capacity (TAC). Succimer 45-49 glutathione peroxidase Oreochromis niloticus 268-271 34775563-6 2022 The results of the present study showed that DMSA and FA decreased malondialdehyde (MDA) and Pb residue in tissues of Pb-exposed fish and improved the histologic picture and brain contents of glutathione (GSH), glutathione-s-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), G6PD, LDH, and total antioxidant capacity (TAC). Succimer 45-49 superoxide dismutase [Mn], mitochondrial Oreochromis niloticus 274-294 34775563-6 2022 The results of the present study showed that DMSA and FA decreased malondialdehyde (MDA) and Pb residue in tissues of Pb-exposed fish and improved the histologic picture and brain contents of glutathione (GSH), glutathione-s-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), G6PD, LDH, and total antioxidant capacity (TAC). Succimer 45-49 superoxide dismutase [Mn], mitochondrial Oreochromis niloticus 296-299 34775563-6 2022 The results of the present study showed that DMSA and FA decreased malondialdehyde (MDA) and Pb residue in tissues of Pb-exposed fish and improved the histologic picture and brain contents of glutathione (GSH), glutathione-s-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), G6PD, LDH, and total antioxidant capacity (TAC). Succimer 45-49 catalase Oreochromis niloticus 302-310 34775563-6 2022 The results of the present study showed that DMSA and FA decreased malondialdehyde (MDA) and Pb residue in tissues of Pb-exposed fish and improved the histologic picture and brain contents of glutathione (GSH), glutathione-s-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), G6PD, LDH, and total antioxidant capacity (TAC). Succimer 45-49 catalase Oreochromis niloticus 312-315 34775563-6 2022 The results of the present study showed that DMSA and FA decreased malondialdehyde (MDA) and Pb residue in tissues of Pb-exposed fish and improved the histologic picture and brain contents of glutathione (GSH), glutathione-s-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), G6PD, LDH, and total antioxidant capacity (TAC). Succimer 45-49 glucose-6-phosphate 1-dehydrogenase Oreochromis niloticus 318-322 34775563-6 2022 The results of the present study showed that DMSA and FA decreased malondialdehyde (MDA) and Pb residue in tissues of Pb-exposed fish and improved the histologic picture and brain contents of glutathione (GSH), glutathione-s-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), G6PD, LDH, and total antioxidant capacity (TAC). Succimer 45-49 L-lactate dehydrogenase A chain Oreochromis niloticus 324-327 34330812-1 2022 We previously reported 68Ga-prostate-specific membrane antigen (PSMA)-11 and 99mTcdimercaptosuccinic acid (DMSA) images of the 1st case of our prospective research comparing renal PSMA PET to DMSA scan in adult patients with pyelonephritis. Succimer 107-111 folate hydrolase 1 Homo sapiens 180-184 34324869-5 2021 (Pt(acac)2)R cells incubated with (Pt(O,O"-acac)(gamma-acac)(DMS)), showed a relevant EGFR activation due to PKC-delta and Src phosphorylation that provoked proliferation and survival through MERK1/2/ERK1/2 and PI3K/Akt pathways. Succimer 61-64 epidermal growth factor receptor Homo sapiens 86-90 34324869-5 2021 (Pt(acac)2)R cells incubated with (Pt(O,O"-acac)(gamma-acac)(DMS)), showed a relevant EGFR activation due to PKC-delta and Src phosphorylation that provoked proliferation and survival through MERK1/2/ERK1/2 and PI3K/Akt pathways. Succimer 61-64 protein kinase C delta Homo sapiens 109-118 34324869-5 2021 (Pt(acac)2)R cells incubated with (Pt(O,O"-acac)(gamma-acac)(DMS)), showed a relevant EGFR activation due to PKC-delta and Src phosphorylation that provoked proliferation and survival through MERK1/2/ERK1/2 and PI3K/Akt pathways. Succimer 61-64 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 123-126 34324869-5 2021 (Pt(acac)2)R cells incubated with (Pt(O,O"-acac)(gamma-acac)(DMS)), showed a relevant EGFR activation due to PKC-delta and Src phosphorylation that provoked proliferation and survival through MERK1/2/ERK1/2 and PI3K/Akt pathways. Succimer 61-64 mitogen-activated protein kinase 3 Homo sapiens 200-206 34324869-5 2021 (Pt(acac)2)R cells incubated with (Pt(O,O"-acac)(gamma-acac)(DMS)), showed a relevant EGFR activation due to PKC-delta and Src phosphorylation that provoked proliferation and survival through MERK1/2/ERK1/2 and PI3K/Akt pathways. Succimer 61-64 AKT serine/threonine kinase 1 Homo sapiens 216-219 35038611-6 2022 Nonetheless, DMSA-MNPs transited at slower rate than APS-MNPs in macrophages as measured by MNP accumulation in Rab7+ endolysosomes. Succimer 13-17 modifier of Niemann Pick type C1 Mus musculus 92-95 34084299-7 2021 Patients with abnormal DMSA had significantly higher serum IL-6 and IL-8 compared with those with normal DMSA scan (187.1 +- 113.1 ng/mL vs. 396.1 +- 246.0 ng/mL, P = 0.005; and 165 +- 76.1 ng/mLvs. Succimer 23-27 interleukin 6 Homo sapiens 59-63 34084299-7 2021 Patients with abnormal DMSA had significantly higher serum IL-6 and IL-8 compared with those with normal DMSA scan (187.1 +- 113.1 ng/mL vs. 396.1 +- 246.0 ng/mL, P = 0.005; and 165 +- 76.1 ng/mLvs. Succimer 23-27 C-X-C motif chemokine ligand 8 Homo sapiens 68-72 35473855-7 2022 At relatively high disaccharide concentrations, DMS-MS of each disaccharide resulted in complex and unique multi-peak spectra with up to ten fully and partially resolved peaks for beta-1,4-mannobiose (Man-1,4beta-Man), which can be attributed to the DMS separation and subsequent dissociation of ionic non-covalently bound oligomers into monomer ions. Succimer 250-253 LEM domain containing 3 Homo sapiens 201-206 35038611-6 2022 Nonetheless, DMSA-MNPs transited at slower rate than APS-MNPs in macrophages as measured by MNP accumulation in Rab7+ endolysosomes. Succimer 13-17 RAB7, member RAS oncogene family Mus musculus 112-116 2560154-1 1989 99Tcm(v)-DMSA is a new tumour-imaging agent which has recently been proposed as a scintigraphic marker for head and neck squamous cell carcinoma (SCC). Succimer 9-13 serpin family B member 3 Homo sapiens 146-149 2560154-7 1989 Although 99Tcm(v)-DMSA is accumulated at sites of head and neck SCC, its inability to detect low volume disease and apparent low specificity following surgery and irradiation means it has no role to play in the routine evaluation of patients with head and neck SCC. Succimer 18-22 serpin family B member 3 Homo sapiens 64-67 2552216-0 1989 [Evaluation of renal scarring in children with primary VUR by 99mTc-DMSA renoscintigraphy]. Succimer 68-72 VUR Homo sapiens 55-58 2544690-1 1989 A recently developed imaging agent, technetium-99m (v) dimercaptosuccinic acid (99mTc (v) DMSA), has been used to assess head and neck squamous carcinoma (SCC). Succimer 55-78 serpin family B member 3 Homo sapiens 155-158 2544690-1 1989 A recently developed imaging agent, technetium-99m (v) dimercaptosuccinic acid (99mTc (v) DMSA), has been used to assess head and neck squamous carcinoma (SCC). Succimer 90-94 serpin family B member 3 Homo sapiens 155-158 2544690-8 1989 This study has shown 99mTc (v) DMSA imaging provides a cheap and rapid method of investigating head and neck SCC and further studies are necessary to evaluate its role in the management of patients with this disease. Succimer 31-35 serpin family B member 3 Homo sapiens 109-112 33647007-9 2021 RESULTS DMSA scanning showed significant differences between the groups with non-dilated VUR, grade III VUR, grades IV-V VUR, and the control group in kidney width (chi2=30.5; P<0.001); position and shape (chi2=30.6; P<0.001); intensity of activity (chi2=38.1; P<0.001); distribution of activity (chi2=34.5; P<0.001); and existence of scars (chi2=16; P<0.001). Succimer 8-12 VUR Homo sapiens 89-92 21043241-8 1981 It is concluded that the high affinity of metallothionein for these cations prevented their elimination from the cytosol and that the interaction of Cd2+ and Cu2+ with DMSA occurred in the particulate fraction and therefore delayed the response to DMSA treatment. Succimer 168-172 Cd2 molecule Rattus norvegicus 149-152 21043241-8 1981 It is concluded that the high affinity of metallothionein for these cations prevented their elimination from the cytosol and that the interaction of Cd2+ and Cu2+ with DMSA occurred in the particulate fraction and therefore delayed the response to DMSA treatment. Succimer 248-252 Cd2 molecule Rattus norvegicus 149-152 21043241-9 1981 It is suggested that long term treatment with DMSA, although ineffective in mobilizing Cd2+ from the kidney may provide a useful therapeutic measure to reduce the liver burden of Cd2+ and the high renal Cu2+ concentrations in the Cd(2+)-exposed animal. Succimer 46-50 Cd2 molecule Rattus norvegicus 179-182 21043241-1 1981 The effect of dimercaptosuccinic acid (DMSA) on the tissue distribution, renal and hepatic subcellular localization of Cd2+, Zn2+ and Cu2+ in Cd(2+)-pretreated male rats and on the tissue distribution of Zn2+ and Cu2+ in the normal rat was studied. Succimer 39-43 Cd2 molecule Rattus norvegicus 119-122 33930476-3 2021 METHODS: ZEB1 promoter G-quadruplexes were studied and modeled extensively using circular dichroism, fluorescence spectroscopy, ITC and DMS protection assay. Succimer 136-139 zinc finger E-box binding homeobox 1 Homo sapiens 9-13 33647007-9 2021 RESULTS DMSA scanning showed significant differences between the groups with non-dilated VUR, grade III VUR, grades IV-V VUR, and the control group in kidney width (chi2=30.5; P<0.001); position and shape (chi2=30.6; P<0.001); intensity of activity (chi2=38.1; P<0.001); distribution of activity (chi2=34.5; P<0.001); and existence of scars (chi2=16; P<0.001). Succimer 8-12 VUR Homo sapiens 104-107 33647007-9 2021 RESULTS DMSA scanning showed significant differences between the groups with non-dilated VUR, grade III VUR, grades IV-V VUR, and the control group in kidney width (chi2=30.5; P<0.001); position and shape (chi2=30.6; P<0.001); intensity of activity (chi2=38.1; P<0.001); distribution of activity (chi2=34.5; P<0.001); and existence of scars (chi2=16; P<0.001). Succimer 8-12 VUR Homo sapiens 104-107 33647007-10 2021 The probability of abnormalities on DMSA scans increased with the VUR grade. Succimer 36-40 VUR Homo sapiens 66-69 33691922-5 2021 RESULTS: Compared with the non-VUR group, the VUR group had a significantly higher proportion of children with non-Escherichia coli urinary tract infection, hydronephrosis (the severity of hydronephrosis increased with the grade of VUR), abnormal 99mTc-DMSA renal scanning findings, elevated ratios of urinary albumin, urinary IgG and urinary transferrin to creatinine, increased residual urine volume, and increased detrusor leak point pressure (P < 0.05). Succimer 253-257 VUR Homo sapiens 46-49 33609918-5 2021 RESULTS: [99mTc]DMSA uptake was significantly higher in Flp293/OAT3 than in mock cells. Succimer 16-20 solute carrier family 22 member 8 Homo sapiens 63-67 33609918-7 2021 [99mTc]DMSA uptake into vesicles that highly expressed MRP2 was significantly higher in adenosine triphosphate (ATP) than in adenosine monophosphate (AMP), and probenecid decreased uptake to similar levels as that in AMP. Succimer 7-11 ATP binding cassette subfamily C member 2 Homo sapiens 55-59 33609918-12 2021 CONCLUSIONS: [99mTc]DMSA accumulates in renal proximal tubular epithelial cells from blood via OAT3 on the basolateral side, and then a small volume of [99mTc]DMSA will be excreted in urine via MRP2. Succimer 20-24 solute carrier family 22 (organic anion transporter), member 8 Mus musculus 95-99 33609918-12 2021 CONCLUSIONS: [99mTc]DMSA accumulates in renal proximal tubular epithelial cells from blood via OAT3 on the basolateral side, and then a small volume of [99mTc]DMSA will be excreted in urine via MRP2. Succimer 20-24 ATP binding cassette subfamily C member 2 Homo sapiens 194-198 33609918-13 2021 ADVANCES IN KNOWLEDGE: [99mTc]DMSA accumulates via OAT3 in renal proximal tubular epithelial cells and is slightly excreted from the cells via MRP2. Succimer 30-34 solute carrier family 22 (organic anion transporter), member 8 Mus musculus 51-55 33609918-13 2021 ADVANCES IN KNOWLEDGE: [99mTc]DMSA accumulates via OAT3 in renal proximal tubular epithelial cells and is slightly excreted from the cells via MRP2. Succimer 30-34 ATP binding cassette subfamily C member 2 Homo sapiens 143-147 33609918-14 2021 IMPLICATIONS FOR PATIENT CARE: [99mTc]DMSA may be useful for measuring renal transport function with OAT3 in patients. Succimer 38-42 solute carrier family 22 member 8 Homo sapiens 101-105 33691922-5 2021 RESULTS: Compared with the non-VUR group, the VUR group had a significantly higher proportion of children with non-Escherichia coli urinary tract infection, hydronephrosis (the severity of hydronephrosis increased with the grade of VUR), abnormal 99mTc-DMSA renal scanning findings, elevated ratios of urinary albumin, urinary IgG and urinary transferrin to creatinine, increased residual urine volume, and increased detrusor leak point pressure (P < 0.05). Succimer 253-257 VUR Homo sapiens 46-49 32790873-3 2020 OBJECTIVES: To evaluate the activity of carbapenems alone or combined with DMSA against MBL-producing Escherichia coli in a severe murine peritonitis model. Succimer 75-79 mannose-binding lectin (protein C) 2 Mus musculus 88-91 33180482-8 2020 The latter are formed via a 6-coordinate intermediate (L)Mn(Por)(eta1-ONO2) (L = THF or DMS) that loses L upon warming. Succimer 88-91 secreted phosphoprotein 1 Homo sapiens 65-69 32790873-7 2020 Bacterial counts in peritoneal fluid and spleen were assessed at 24 h. RESULTS: DMSA in combination with each carbapenem caused a significant decrease in the MICs for all MBL-producing strains, in a concentration-dependent manner, but did not provide benefit against non-MBL strains. Succimer 80-84 mannose-binding lectin (protein C) 2 Mus musculus 171-174 32790873-7 2020 Bacterial counts in peritoneal fluid and spleen were assessed at 24 h. RESULTS: DMSA in combination with each carbapenem caused a significant decrease in the MICs for all MBL-producing strains, in a concentration-dependent manner, but did not provide benefit against non-MBL strains. Succimer 80-84 mannose-binding lectin (protein C) 2 Mus musculus 271-274 32790873-10 2020 CONCLUSIONS: DMSA restores the activity of carbapenems against MBL-producing strains, and its combination with carbapenems appears to be a promising strategy for the treatment of NDM-producing E. coli infections. Succimer 13-17 mannose-binding lectin (protein C) 2 Mus musculus 63-66 32291276-6 2020 Dimercaptosuccinic acid capsules were prescribed and memory recovered to some extent, which was accompanied by decreased insulin dosage for glucose control by 5 units. Succimer 0-23 insulin Homo sapiens 121-128 32543165-0 2020 Using 99mTc-(V)-DMSA to follow the vascular calcification process in vascular smooth muscle cells based on pit-1 expression. Succimer 16-20 POU class 1 homeobox 1 Rattus norvegicus 107-112 32543165-3 2020 [99mTc]-Pentavalent dimercaptosuccinic acid (99mTc-(V)-DMSA) was mediated by PiT-1 transporter in tumoral cells and we propose its evaluation in a vascular calcification in vitro model. Succimer 20-43 POU class 1 homeobox 1 Rattus norvegicus 77-82 32543165-4 2020 The aim of this study was to determine if 99mTc-(V)-DMSA can follow the vascular calcification process in vascular smooth muscle cells (VSMCs) based on PiT-1 expression. Succimer 52-56 POU class 1 homeobox 1 Rattus norvegicus 152-157 32543165-11 2020 PiT-1 inhibition with phosphonoformic acid completely reverse the calcium deposition as well as the 99mTc-(V)- DMSA uptake. Succimer 111-115 POU class 1 homeobox 1 Rattus norvegicus 0-5 31823190-8 2020 In addition, urine NGAL/Cr increased significantly in patients with decreased parenchymal function, compared to those with normal DMSA scan. Succimer 130-134 lipocalin 2 Homo sapiens 19-23 31214960-2 2019 In addition, dimercaptosuccinic acid renal scintigraphy (DMSA) is an important diagnostic modality of VUR. Succimer 13-36 VUR Homo sapiens 102-105 31718892-2 2020 METHODS: In this study, a pH-responsive DMSA-Fe3O4 magnetic nanoparticles (MNPs) covalently connect with ADM and As2O3 as a drug delivery system was invented to discuss the anticancer efficacy in non-Hodgkin"s lymphoma (NHL) cell line--Raji. Succimer 40-44 adrenomedullin Homo sapiens 105-108 31214960-2 2019 In addition, dimercaptosuccinic acid renal scintigraphy (DMSA) is an important diagnostic modality of VUR. Succimer 57-61 VUR Homo sapiens 102-105 32454726-8 2019 The mRNA expression levels of p53, caspase-3, caspase-9, Bax, Bcl-2, and survivin genes were altered in the cells exposed to 500 and 1000 mug/mL DMSA/Ag2S QDs. Succimer 145-149 cellular tumor antigen p53 Cricetulus griseus 30-33 32454726-8 2019 The mRNA expression levels of p53, caspase-3, caspase-9, Bax, Bcl-2, and survivin genes were altered in the cells exposed to 500 and 1000 mug/mL DMSA/Ag2S QDs. Succimer 145-149 caspase-3 Cricetulus griseus 35-44 32454726-8 2019 The mRNA expression levels of p53, caspase-3, caspase-9, Bax, Bcl-2, and survivin genes were altered in the cells exposed to 500 and 1000 mug/mL DMSA/Ag2S QDs. Succimer 145-149 caspase-9 Cricetulus griseus 46-55 32454726-8 2019 The mRNA expression levels of p53, caspase-3, caspase-9, Bax, Bcl-2, and survivin genes were altered in the cells exposed to 500 and 1000 mug/mL DMSA/Ag2S QDs. Succimer 145-149 apoptosis regulator BAX Cricetulus griseus 57-60 32454726-8 2019 The mRNA expression levels of p53, caspase-3, caspase-9, Bax, Bcl-2, and survivin genes were altered in the cells exposed to 500 and 1000 mug/mL DMSA/Ag2S QDs. Succimer 145-149 apoptosis regulator Bcl-2 Cricetulus griseus 62-67 32454726-8 2019 The mRNA expression levels of p53, caspase-3, caspase-9, Bax, Bcl-2, and survivin genes were altered in the cells exposed to 500 and 1000 mug/mL DMSA/Ag2S QDs. Succimer 145-149 survivin Cricetulus griseus 73-81 30741838-3 2019 The aim of this study was to evaluate cyclic DRC with DMSA scan results during the follow-up period in children with a prior diagnosis of VUR. Succimer 54-58 VUR Homo sapiens 138-141 31695366-0 2019 Vitamin E succinate-grafted-chitosan/chitosan oligosaccharide mixed micelles loaded with C-DMSA for Hg2+ detection and detoxification in rat liver. Succimer 89-95 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 100-103 31695366-6 2019 Results: The C-DMSA loaded mixed micelles, C-DMSA@VES-g-CSO/VES-g-CS MM, significantly enhanced cellular uptake and detoxification efficacy of C-DMSA in Hg2+ pretreated human L929 cells. Succimer 13-19 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 153-156 31695366-6 2019 Results: The C-DMSA loaded mixed micelles, C-DMSA@VES-g-CSO/VES-g-CS MM, significantly enhanced cellular uptake and detoxification efficacy of C-DMSA in Hg2+ pretreated human L929 cells. Succimer 43-49 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 153-156 31695366-6 2019 Results: The C-DMSA loaded mixed micelles, C-DMSA@VES-g-CSO/VES-g-CS MM, significantly enhanced cellular uptake and detoxification efficacy of C-DMSA in Hg2+ pretreated human L929 cells. Succimer 43-49 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 153-156 30741838-15 2019 CONCLUSION: Functional classification of VUR into continuous and transient reflux resulted in higher correlation with DMSA scan findings compared with anatomic reflux grading in follow-up patients with VUR. Succimer 118-122 VUR Homo sapiens 41-44 30787607-12 2019 Conclusion: These results indicate that Fe3O4@DMSA@Ab nanoprobes have the potential to serve as MRI tracers and therapeutic agents for CD20-positive cells. Succimer 46-50 keratin 20 Homo sapiens 135-139 31384085-3 2019 This study looked at renal scarring following UTI in children by dimercaptosuccinic acid (DMSA) scan. Succimer 65-88 alpha-1-microglobulin/bikunin precursor Homo sapiens 46-49 30787607-8 2019 Results: Cell targeting experiments and magnetic resonance (MR) signal and T2 measurements showed that the Fe3O4@DMSA@Ab nanoprobes have specific binding affinity for CD20-positive cells. Succimer 113-117 keratin 20 Homo sapiens 167-171 31384085-3 2019 This study looked at renal scarring following UTI in children by dimercaptosuccinic acid (DMSA) scan. Succimer 90-94 alpha-1-microglobulin/bikunin precursor Homo sapiens 46-49 31384085-11 2019 DMSA, being the non-invasive test, is better proven to be an investigation of choice than other invasive modalities for follow-up of children with recurrent attacks of UTI. Succimer 0-4 alpha-1-microglobulin/bikunin precursor Homo sapiens 168-171 27591569-4 2016 Upon addition of meso-2,3-dimercaptosuccinic acid into aqueous solutions of PPL-S-S-Py and POEGMA-co-PDEGMA-co-PDSMA, enzyme-polymer hybrid nanogels were prepared. Succimer 17-49 periplakin Homo sapiens 76-79 29576374-11 2018 CONCLUSION: Decreased relative function and increased extents of cortical defects on DMSA scan may be associated with the presence of VUR. Succimer 85-89 VUR Homo sapiens 134-137 27889952-5 2018 Significantly, through determination of western blotting and immunofluorescence of connexin 43, N-cadherin, desmoplakin, and plakoglobin, DMSA-IRONs enhanced the assembly of gap junctions, decreased mechanical junctions (adherens junctions and desmosomes) of cardiac cells but not in dose-dependent manner in ECTs at seventh day. Succimer 138-142 gap junction protein alpha 1 Homo sapiens 83-94 27889952-5 2018 Significantly, through determination of western blotting and immunofluorescence of connexin 43, N-cadherin, desmoplakin, and plakoglobin, DMSA-IRONs enhanced the assembly of gap junctions, decreased mechanical junctions (adherens junctions and desmosomes) of cardiac cells but not in dose-dependent manner in ECTs at seventh day. Succimer 138-142 cadherin 2 Homo sapiens 96-106 28319815-3 2017 According to their morphology and peroxidase-like activity, dimercaptosuccinic acid (DMSA) modified Co3O4 nanopolyhedrons synthesized via coprecipitation method (Co3O4 NHs) were selected as a proper candidate for the immunohistochemical (IHC) detection of epidermal growth factor receptor (EGFR) expression in non-small cell lung cancer (NSCLC) tissues. Succimer 60-83 epidermal growth factor receptor Homo sapiens 256-288 28319815-3 2017 According to their morphology and peroxidase-like activity, dimercaptosuccinic acid (DMSA) modified Co3O4 nanopolyhedrons synthesized via coprecipitation method (Co3O4 NHs) were selected as a proper candidate for the immunohistochemical (IHC) detection of epidermal growth factor receptor (EGFR) expression in non-small cell lung cancer (NSCLC) tissues. Succimer 60-83 epidermal growth factor receptor Homo sapiens 290-294 28319815-3 2017 According to their morphology and peroxidase-like activity, dimercaptosuccinic acid (DMSA) modified Co3O4 nanopolyhedrons synthesized via coprecipitation method (Co3O4 NHs) were selected as a proper candidate for the immunohistochemical (IHC) detection of epidermal growth factor receptor (EGFR) expression in non-small cell lung cancer (NSCLC) tissues. Succimer 85-89 epidermal growth factor receptor Homo sapiens 256-288 28319815-3 2017 According to their morphology and peroxidase-like activity, dimercaptosuccinic acid (DMSA) modified Co3O4 nanopolyhedrons synthesized via coprecipitation method (Co3O4 NHs) were selected as a proper candidate for the immunohistochemical (IHC) detection of epidermal growth factor receptor (EGFR) expression in non-small cell lung cancer (NSCLC) tissues. Succimer 85-89 epidermal growth factor receptor Homo sapiens 290-294 30089989-9 2018 On the other side, 79% of the patients with high-grade VUR had severe DMSA findings. Succimer 70-74 VUR Homo sapiens 55-58 28984254-4 2017 Combined USG and DMSA had a negative predictive value of 94% for significant VUR. Succimer 17-21 VUR Homo sapiens 77-80